The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress.
The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.
van Hall
Thorbald
T
Department of Clinical Oncology, Leiden University Medical Center, K1-P, Albinusdreef 2, 2333 ZA Leiden, Netherlands. T.van_Hall@LUMC.nl
Oliveira
Claudia C
CC
Joosten
Simone A
SA
Ottenhoff
Tom H M
TH
D000818:Animals; D017951:Antigen Presentation; D006680:HLA Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice; D015398:Signal Transduction; D000097625:HLA-E Antigens
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens; C032907:Q surface antigens