Insertion/insertion genotype of α(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus.
OBJECTIVE
We investigated whether α(2)-adrenergic receptor (AR) polymorphisms (α(2A)-AR, α(2B)-AR and α(2C)-AR gene) affected silent myocardial ischemia (SMI) in patients with type 2 diabetes mellitus (T2DM).


METHODS
Genetic polymorphisms were determined in 321 patients with T2DM and coronary artery disease (CAD). Among them, 129 patients experienced transient asymptomatic ST-depression during 24-hour ambulatory electrocardiogram (SMI group), and the remaining 192 patients who had ambulatory electrocardiogram-symptom matching angina were categorized as angina group.


RESULTS
The genotype distribution and allele frequencies of α(2B)-AR gene polymorphism (insertion [I]/deletion[D]) exhibited significant difference between SMI group and angina group (both P < 0.05), with genotype II (34.9%) being higher in SMI group than in angina group (19.8%) (P < 0.01). Multivariable logistic regression analysis revealed that duration of diabetes and genotype II of α(2B)-AR gene polymorphism were independently associated with SMI.


CONCLUSIONS
Homozygote for I allele of α(2B)-AR gene polymorphism is associated with SMI in T2DM patients with CAD.
Chen
Qiu Jing
QJ
Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China.
Lu
Lin
L
Jin
Cao
C
Wang
Ling Jie
LJ
Zhang
Rui Yan
RY
Zhang
Qi
Q
Hu
Jian
J
Yang
Zhen Kun
ZK
Shen
Wei Feng
WF
D000368:Aged; D016207:Cytokines / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D016254:Mutagenesis, Insertional / Q000235:genetics*; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications* / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012044:Regression Analysis
C547771:ADRA2B protein, human; D016207:Cytokines; D018341:Receptors, Adrenergic, alpha-2