Genome-wide association study of pancreatic cancer in Japanese population.
Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5x10(-7)) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30x10(-7), 3.30x10(-7), and 4.41x10(-7); located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
Low
Siew-Kee
SK
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, Department of Medical Genome Sciences, Graduate School of Frontier Scineces, the University of Tokyo, National Cancer Center Hospital, Tokyo, Japan.
Kuchiba
Aya
A
Zembutsu
Hitoshi
H
Saito
Akira
A
Takahashi
Atsushi
A
Kubo
Michiaki
M
Daigo
Yataro
Y
Kamatani
Naoyuki
N
Chiku
Suenori
S
Totsuka
Hirohiko
H
Ohnami
Sumiko
S
Hirose
Hiroshi
H
Shimada
Kazuaki
K
Okusaka
Takuji
T
Yoshida
Teruhiko
T
Nakamura
Yusuke
Y
Sakamoto
Hiromi
H
D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics