title: Clinical applications of molecular biomarkers in prostate cancer detection.
abstract: Prostate cancer is a heterogeneous disease with regard to molecular alterations and clinical course. Early diagnosis of prostate cancer can increase the curative success rate for this disease. Because of the recent developments in the field of molecular biology, an increased interest occurred for molecular biomarkers, as tools for early prostate cancer detection, monitoring disease progression, predicting disease recurrence and therapeutic treatment efficacy. Many molecular biomarkers have been discovered in human serum, urine, seminal fluid and histological specimens.
authors.affiliation: V. Babeş University of Medicine and Pharmacy, Timişoara School of Medicine, Department of Biochemistry.
authors.forename: Raluca
authors.initials: R
authors.lastname: Dumache
authors.forename: F
authors.initials: F
authors.lastname: Miclea
authors.forename: B
authors.initials: B
authors.lastname: Bumblăcilă
authors.forename: Maria
authors.initials: M
authors.lastname: Puiu
mesh_terms: D017318:Annexin A3 / Q000097:blood; D000951:Antigens, Neoplasm / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D055088:Early Detection of Cancer; D051549:Glutathione S-Transferase pi / Q000097:blood; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007610:Kallikreins / Q000097:blood; D008297:Male; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D019998:Racemases and Epimerases / Q000097:blood; D019947:Receptors, Interleukin-6 / Q000097:blood; D012680:Sensitivity and Specificity; D012697:Serine Endopeptidases / Q000097:blood; D025521:Tumor Suppressor Proteins / Q000097:blood
chemical_list: D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D018969:Insulin-Like Growth Factor Binding Proteins; C411762:RASSF1 protein, human; D019947:Receptors, Interleukin-6; D025521:Tumor Suppressor Proteins; C479341:prostate cancer antigen 3, human; D051549:Glutathione S-Transferase pi; D017318:Annexin A3; D007610:Kallikreins; D012697:Serine Endopeptidases; C421305:TMPRSS2 protein, human; D017430:Prostate-Specific Antigen; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase