title: Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp.
abstract: Previous studies have shown that venoms of social wasps and bees exhibit strong anticoagulant activity. The present study describes the anticoagulant and fibrinogen-degrading pharmacological properties of the venom of Polybia occidentalis social wasp. The results demonstrated that this venom presented anticoagulant effect, inhibiting the coagulation at different steps of the clotting pathway (intrinsic, extrinsic and common pathway). The venom inhibited platelet aggregation and degraded plasma fibrinogen, possibly containing metal-dependent metalloproteases that specifically cleave the Bβ-chain of fibrinogen. In conclusion, fibrinogenolytic and anticoagulant properties of this wasp venom find a potential application in drug development for the treatment of thrombotic disorders. For that, further studies should be carried out in order to identify and isolate the active compounds responsible for these effects.
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto/USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Paula G
authors.initials: PG
authors.lastname: Czaikoski
authors.forename: Danilo L
authors.initials: DL
authors.lastname: Menaldo
authors.forename: Silvana
authors.initials: S
authors.lastname: Marcussi
authors.forename: Anne L C
authors.initials: AL
authors.lastname: Baseggio
authors.forename: André L
authors.initials: AL
authors.lastname: Fuly
authors.forename: Rafael C
authors.initials: RC
authors.lastname: Paula
authors.forename: Andreza U
authors.initials: AU
authors.lastname: Quadros
authors.forename: Pedro R T
authors.initials: PR
authors.lastname: Romão
authors.forename: Maria L T
authors.initials: ML
authors.lastname: Buschini
authors.forename: Fernando Q
authors.initials: FQ
authors.lastname: Cunha
authors.forename: Andreimar M
authors.initials: AM
authors.lastname: Soares
authors.forename: Marta C
authors.initials: MC
authors.lastname: Monteiro
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D045726:Metalloproteases / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D014862:Wasp Venoms / Q000494:pharmacology*; D014863:Wasps
chemical_list: D000925:Anticoagulants; D014862:Wasp Venoms; D005340:Fibrinogen; D045726:Metalloproteases