Indoor use of plastic sheeting impregnated with carbamate combined with long-lasting insecticidal mosquito nets for the control of pyrethroid-resistant malaria vectors.
The combined efficacy of a long-lasting insecticidal net (LLIN) and a carbamate-treated plastic sheeting (CTPS) or indoor residual spraying (IRS) for control of insecticide-resistant mosquitoes was evaluated in experimental huts in Burkina Faso. Anopheles gambiae from the area is resistant to pyrethroids and to a lesser extent, carbamates. Relatively low mortality rates were observed with the LLIN (44%), IRS (42%), and CTPS (52%), whereas both combinations killed significantly more mosquitoes (~70% for LLIN + CTPS and LLIN + IRS). Blood feeding by An. gambiae was uninhibited by IRS and CTPS compared with LLIN (43%), LLIN + CTPS (58%), and LLIN + IRS (56%). No evidence for selection of the kdr and ace-1(R) alleles was observed with the combinations, whereas a survival advantage of mosquitoes bearing the ace-1(R) mutation was observed with IRS and CTPS. The results suggest that the combination of the two interventions constitutes a potential tool for vector-resistance management.
Djènontin
Armel
A
Centre de Recherche Entomologique de Cotonou, Unité de Recherche 016 Institut de Recherche pour le Développement, Cotonou, Bénin. armeldj@yahoo.fr
Chandre
Fabrice
F
Dabiré
K Roch
KR
Chabi
Joseph
J
N'guessan
Raphael
R
Baldet
Thierry
T
Akogbéto
Martin
M
Corbel
Vincent
V
D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007303:Insect Vectors / Q000187:drug effects* / Q000235:genetics; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009032:Mosquito Control; D057147:Mosquito Nets; D009154:Mutation; D048448:Phenylcarbamates / Q000494:pharmacology*; D010969:Plastics; D011722:Pyrethrins / Q000494:pharmacology
D007306:Insecticides; D048448:Phenylcarbamates; D010969:Plastics; D011722:Pyrethrins; C007725:bendiocarb