Antiviral drug resistance: mechanisms and clinical implications.
Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.
Strasfeld
Lynne
L
Division of Infectious Diseases, Oregon Health & Science University, Portland, OR 97239, USA. strasfel@ohsu.edu
Chou
Sunwen
S
D000998:Antiviral Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D024882:Drug Resistance, Viral; D006509:Hepatitis B / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D013997:Time Factors; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents