title: Development of a 2-aza-Cope-[3 + 2] dipolar cycloaddition strategy for the synthesis of quaternary proline scaffolds.
abstract: A one-pot multicomponent procedure for the synthesis of highly functionalized pyrrolidine rings through a domino 2-aza-Cope-[3 + 2] dipolar cycloaddition sequence has been demonstrated. This protocol was found to be both high-yielding and stereoselective for the endo cycloadduct.
authors.affiliation: Department of Chemistry, The University of Vermont, 82 University Place, Burlington, Vermont 05405, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: McCormack
authors.forename: Tamila
authors.initials: T
authors.lastname: Shalumova
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Tanski
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Waters
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011759:Pyrrolidines; D011392:Proline