title: Systolic blood pressure contributes to intracerebral haemorrhage after thrombolysis for ischemic stroke.
abstract: The frequency and risk factors for intracerebral haemorrhage (ICH) after ischemic stroke are well-known. ICH frequency is increased by the use of antithrombotic or thrombolytic drugs. Several experimental studies have demonstrated a relationship between ICH and hypertension after fibrinolysis, but the optimal blood pressure levels in patients treated with recombinant tissue plasminogen activator (rTPA) are as yet unknown. We evaluated the role of blood pressure in patients with ischemic stroke treated with rTPA within 3h of symptom onset. We treated 86 consecutive patients admitted to our stroke unit between 2002 and 2008 and prospectively recorded the clinical and instrumental data in our stroke registry. We evaluated haemorrhagic complications by reviewing imaging findings. Blood pressure was recorded before rTPA and at 6, 12, 18, and 32h. Total cerebral haemorrhage occurred in eleven (12.7%) patients, and symptomatic intracerebral haemorrhage occurred in seven (8.1%). We failed to find a correlation between blood pressure levels and stroke severity at admission. High blood pressure levels correlated with a worse outcome. Systolic blood pressure was significantly higher in ICH patients relative to rTPA-treated patients without haemorrhagic complications (p<0.03). This study indicates that rTPA-induced haemorrhage is influenced by systolic blood pressure. More aggressive pharmacological reduction of hypertension during fibrinolysis and the subsequent 32h may reduce this complication.
authors.affiliation: Neurology Ward, St. Bortolo Hospital, Vicenza Italy. francesco.perini@ulssvicenza.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Perini
authors.forename: Antonella
authors.initials: A
authors.lastname: De Boni
authors.forename: Michela
authors.initials: M
authors.lastname: Marcon
authors.forename: Irene
authors.initials: I
authors.lastname: Bolgan
authors.forename: Michele
authors.initials: M
authors.lastname: Pellizzari
authors.forename: Laura Di
authors.initials: LD
authors.lastname: Dionisio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000494:pharmacology*
chemical_list: D010959:Tissue Plasminogen Activator