title: Repeating gastric biopsy for accuracy of gastric lymphoma diagnosis.
abstract: Gastric lymphoma is characterized by a good prognosis with slow progression and a nonspecific appearance under the endoscope. A biopsy is performed for accurate diagnosis. For this study, endoscopy and biopsy specimens were analyzed retrospectively to investigate the rate of accurate diagnosis of gastric lymphoma in first-, second-, and third-round endoscopic and biopsy procedures and to understand the causes of discrepancies. Fifty-four cases of gastric lymphoma were diagnosed in 32,000 patients. The rate of positive Helicobacter pylori infection was 70.4%. Of these, 13 cases were diffuse large B-cell lymphoma and 41 cases were marginal zone B-cell lymphoma. Thirty-two gastric lymphoma cases (59.3%) were diagnosed by first-round endoscopy and biopsy, 13 (24.1%) cases required second-round endoscopy and biopsy, and 9 (16.7%) cases were determined in the third round of endoscopic and biopsy procedures. Repeating endoscopy and biopsy reduced discrepancies in the diagnosis of gastric lymphoma by 40.8%, which can significantly improve the overall accuracy of diagnosis and treatment of gastric lymphoma.
authors.affiliation: Department of Gastroenterology, The Second Hospital of Shandong University, Shandong, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Xu
authors.forename: Chengjun
authors.initials: C
authors.lastname: Zhou
authors.forename: Gangfeng
authors.initials: G
authors.lastname: Zhang
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D003951:Diagnostic Errors / Q000517:prevention & control* / Q000706:statistics & numerical data; D005260:Female; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000473:pathology*