title: In vivo growth of retinoblastoma in a newborn infant.
abstract: Retinoblastoma is a rare malignancy of the retina seen exclusively in children. It is known to cause rapid growth inside the eye and hence treatment should be started as soon as it is diagnosed. We report a case in a five-day-old infant in whom treatment (chemotherapy) was delayed by a month due to high bilirubin levels secondary to physiological jaundice, which gave us the unique opportunity to measure the growth of the tumor over a month. This case emphasizes that immediate treatment is warranted once this rare disease is diagnosed.
authors.affiliation: Pediatric Retina and Ocular Oncology Department, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
authors.forename: Parag K
authors.initials: PK
authors.lastname: Shah
authors.forename: V
authors.initials: V
authors.lastname: Narendran
authors.forename: N
authors.initials: N
authors.lastname: Kalpana
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D006979:Hyperthermia, Induced; D007231:Infant, Newborn; D007565:Jaundice / Q000150:complications; D019572:Retinal Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D012175:Retinoblastoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin