[Present status of pediatric living-donor liver transplantation in National Center for Child Health and Development].
OBJECTIVE
We reviewed our initial experience of pediatric living-donor liver transplantation (LDLT) in National Center for Child Health and Development and report the results herein.


METHODS
We have done 103 cases of LDLT during November 2005 through September 2009 in National Center for Child Health and Development. Variables including indication of liver transplantation/infectious/immunological outcome were reviewed.


RESULTS
The indication for liver transplantation was cholestatic liver disease in 43.76%, followed by metabolic liver disease 24.3% and acute liver failure 18.5%. The mean age of recipient was 3.6 +/- 4.2 years and body weight was 14.4 +/- 11.1kg. Immunosuppression consisted of tacrolimus and low-dose steroids. The incidence of acute cellular rejection was 33.3%. The graft and patient survival were 92.2%.


CONCLUSIONS
Satisfactory result can be achieved on LDLT program in National Center for Child Health and Development. The follow-up period was too short to make definitive conclusion, however, long-term observation may be necessary to collect sufficient data for the establishment of the treatment modality.
Kasahara
Mureo
M
Transplantation Surgery, National Center for Child Health and Development, Tokyo, Japan.
Sakamoto
Seisuke
S
Shigeta
Takanobu
T
Fukuda
Akinari
A
Matsuno
Naoto
N
Tanaka
Hideaki
H
Kitano
Yoshihiro
Y
Kuroda
Tatsuo
T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000209:etiology; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors; D011183:Postoperative Complications; D016896:Treatment Outcome