Anatomical differences and network characteristics underlying smoking cue reactivity.
A distributed network of brain regions is linked to drug-related cue responding. However, the relationships between smoking cue-induced phasic activity and possible underlying differences in brain structure, tonic neuronal activity and connectivity between these brain areas are as yet unclear. Twenty-two smokers and 22 controls viewed smoking-related and neutral pictures during a functional arterial spin labeling scanning session. T1, resting functional, and diffusion tensor imaging data were also collected. Six brain areas, dorsal lateral prefrontal cortex (dlPFC), dorsal medial prefrontal cortex (dmPFC), dorsal anterior cingulate cortex/cingulate cortex, rostral anterior cingulate cortex (rACC), occipital cortex, and insula/operculum, showed significant smoking cue-elicited activity in smokers when compared with controls and were subjected to secondary analysis for resting state functional connectivity (rsFC), structural, and tonic neuronal activity. rsFC strength between rACC and dlPFC was positively correlated with the cue-elicited activity in dlPFC. Similarly, rsFC strength between dlPFC and dmPFC was positively correlated with the cue-elicited activity in dmPFC while rsFC strength between dmPFC and insula/operculum was negatively correlated with the cue-elicited activity in both dmPFC and insula/operculum, suggesting these brain circuits may facilitate the response to the salient smoking cues. Further, the gray matter density in dlPFC was decreased in smokers and correlated with cue-elicited activity in the same brain area, suggesting a neurobiological mechanism for the impaired cognitive control associated with drug use. Taken together, these results begin to address the underlying neurobiology of smoking cue salience, and may speak to novel treatment strategies and targets for therapeutic interventions.
Zhang
Xiaochu
X
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA.
Salmeron
Betty Jo
BJ
Ross
Thomas J
TJ
Gu
Hong
H
Geng
Xiujuan
X
Yang
Yihong
Y
Stein
Elliot A
EA
D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D003463:Cues; D005260:Female; D006179:Gyrus Cinguli / Q000033:anatomy & histology; D006225:Hand / Q000294:innervation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net; D017397:Prefrontal Cortex / Q000033:anatomy & histology; D012016:Reference Values; D012907:Smoking / Q000523:psychology*; D016540:Smoking Cessation / Q000523:psychology*; D055815:Young Adult