Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy.
Anti-SOX1 antibodies have been described to be positive in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and, in a lower amount, in patients with anti-Hu positive paraneoplastic neurological syndromes, and with SCLC alone, respectively. We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). All patients with neuropathy of unknown origin where followed up for four years without diagnosis of a tumour so far. Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies.
Tschernatsch
M
M
Dept. of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany. Marlene.Tschernatsch@neuro.med.uni-giessen.de
Singh
P
P
Gross
O
O
Gerriets
T
T
Kneifel
N
N
Probst
C
C
Malas
S
S
Kaps
M
M
Blaes
F
F
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001323:Autoantibodies / Q000378:metabolism*; D002461:Cell Line, Transformed; D051959:ELAV Proteins / Q000276:immunology; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology* / Q000378:metabolism; D020361:Paraneoplastic Syndromes, Nervous System / Q000145:classification / Q000276:immunology / Q000378:metabolism; D055748:SOXB1 Transcription Factors / Q000276:immunology*; D014162:Transfection / Q000379:methods
D001323:Autoantibodies; D051959:ELAV Proteins; D055748:SOXB1 Transcription Factors