title: Standardized FDG uptake as a prognostic variable and as a predictor of incomplete cytoreduction in primary advanced ovarian cancer.
abstract: BACKGROUND
  In patients with advanced ovarian cancer undergoing preoperative PET/CT, we investigated the prognostic value of SUV in the primary tumor and we evaluated the value of SUV for predicting incomplete primary cytoreduction (macroscopic residual tumor).
  
  
  METHODS
  From September 2004 to August 2007, 201 consecutive patients with a pelvic tumor and a Risk of Malignancy Index (RMI) > 150 based on serum CA-125, ultrasound examinations and menopausal state, underwent PET/CT within two weeks prior to standard surgery/debulking of a pelvic tumor. At two-year follow-up (August 15, 2009) the association between SUV and overall survival/cytoreductive result were analyzed in 60 ovarian cancer patients (58 stage III and two stage IV).
  
  
  RESULTS
  At inclusion median age was 62 years (range 35-85 years); 97% (58/60) had a performance status ≤2; 42% (25/60) underwent complete debulking (no macroscopic residual tumor); median SUV(max) was 13.5 (range 2.5-39.0). Median follow-up was 30.2 months. At follow-up 57% (34/60) were alive and 43% (26/60) had died from ovarian cancer. SUV(max) in patients alive was not statistically different from SUV(max) in dead patients (p=0.69), and SUV(max) was not correlated with the amount of residual tumor after surgery (p=0.19). Using univariate Cox regression analysis, residual tumor was a significant prognostic variable (p=0.001); SUV(max) was not a statistically significant prognostic variable (p=0.86).
  
  
  CONCLUSIONS
  FDG uptake (SUV(max)) in the primary tumor of patients with advanced ovarian cancer was not a prognostic variable and the FDG uptake did not predict complete cytoreduction after primary surgery. Future prospective clinical trials will need to clarify if other PET tracers can serve as prognostic variables in ovarian cancer.
authors.affiliation: Department of Oncology, the Finsen Center, Rigshospitalet, Copenhagen University Hospital, Denmark. signerisum@hotmail.com
authors.forename: Signe
authors.initials: S
authors.lastname: Risum
authors.forename: Annika
authors.initials: A
authors.lastname: Loft
authors.forename: Claus
authors.initials: C
authors.lastname: Høgdall
authors.forename: Anne K
authors.initials: AK
authors.lastname: Berthelsen
authors.forename: Estrid
authors.initials: E
authors.lastname: Høgdall
authors.forename: Lene
authors.initials: L
authors.lastname: Lundvall
authors.forename: Lotte
authors.initials: L
authors.lastname: Nedergaard
authors.forename: Svend A
authors.initials: SA
authors.lastname: Engelholm
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D018450:Disease Progression; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods / Q000592:standards; D049268:Positron-Emission Tomography / Q000379:methods / Q000592:standards; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D019788:Fluorodeoxyglucose F18