title: Azaphilone and isocoumarin derivatives from the endophytic fungus Penicillium sclerotiorum PSU-A13.
abstract: Two new azaphilone derivatives, penicilazaphilones A (1) and B (2), and one new isocoumarin, penicilisorin (3), together with six known compounds were isolated from the endophytic fungus Penicillium sclerotiorum PSU-A13. Their structures were identified by analysis of spectroscopic data. The antimicrobial activity against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans as well as the inhibitory effect on human immunodeficiency virus (HIV)-1 integrase and protease were examined.
authors.affiliation: Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Arunpanichlert
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Yaowapa
authors.initials: Y
authors.lastname: Sukpondma
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.forename: Supinya
authors.initials: S
authors.lastname: Tewtrakul
authors.forename: Nuttawut
authors.initials: N
authors.lastname: Rungjindamai
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001578:Benzopyrans; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D019427:HIV Integrase / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D049934:Isocoumarins; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000737:chemistry*; D010860:Pigments, Biological; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001578:Benzopyrans; D019428:HIV Integrase Inhibitors; D017320:HIV Protease Inhibitors; D049934:Isocoumarins; D010860:Pigments, Biological; D010936:Plant Extracts; C494154:azaphilone; D019427:HIV Integrase; D016333:HIV Protease