Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall.
OBJECTIVE
To verify if the composit poli (2-hydroxyethyl methacrylate)-PolyHEMA/polypropylene mesh implanted in the female rat's abdominal wall could be suitable for the prevention of peritoneal adhesions, and for the evaluation of the tecidual response produced by this biomaterial.


METHODS
Polypropylene meshes (Group PP, n=20) and polypropylene meshes coated with a layer of poli (2-hydroxyethyl methacrylate)-PolyHEMA (Group PH, n=20) were implanted on the abdominal wall of Wistar female rats. Ten animals from each group were submitted to euthanasia at 15 and 30 days of the postoperative period.


RESULTS
The animals from the group PP presented visceral adhesions on the mesh surface, which was not observed in the ones from group PH. At the histopathological examination foreign body response was observed in both groups, whilst there was a greater intensity of inflammatory response in group PH on both moments.


CONCLUSIONS
The poli (2-hydroxyethyl methacrylate) polyHEMA hydrogel associated to polypropylene mesh reduces visceral adhesion formation in rats, although it may be associated to greater inflammatory reaction.
Paulo
Neusa Margarida
NM
Veterinary Surgery, Department of Veterinary Medicin, Universidade Federal de Goiás, Goiânia, GO, Brazil. nmp@vet.ufg.br
Malmonge
Sonia Maria
SM
Menezes
Liliana Borges de
LB
Lima
Flávia Gontijo de
FG
Faria
Aline de Moraes
Ade M
Andrasckho
Mariana Moreira
MM
Moreira
Natalia Menezes
NM
Atayde
Ingrid Bueno
IB
Silva
Marcelo Seixo de Brito e
MS
D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D020007:Implants, Experimental; D007249:Inflammation / Q000473:pathology; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D010537:Peritoneum / Q000187:drug effects* / Q000473:pathology; D011102:Polyhydroxyethyl Methacrylate / Q000009:adverse effects; D011126:Polypropylenes / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
D001672:Biocompatible Materials; D011126:Polypropylenes; D011102:Polyhydroxyethyl Methacrylate