title: Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.
abstract: Three new 5-carbon-linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin in only 3-steps and 40-50% overall yields. Each one of these new chemical entities is at least as efficacious as the clinically used trioxane antimalarial drug artemether when combined with mefloquine hydrochloride in a low single oral dose cure.
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218.
authors.forename: Deuk Kyu
authors.initials: DK
authors.lastname: Moon
authors.forename: Vandana
authors.initials: V
authors.lastname: Singhal
authors.forename: Nirbhay
authors.initials: N
authors.lastname: Kumar
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Shapiro
authors.forename: Gary H
authors.initials: GH
authors.lastname: Posner