Synthesis of gamma-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides.
A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields.
Casey
Brian M
BM
Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Eakin
Cynthia A
CA
Flowers
Robert A
RA