Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes.
Angiomyolipoma (AML) is the most common benign mesenchymal neoplasm of the kidneys with well-established clinical and morphological features. The oral and maxillofacial pathology literature contains several examples that identify angiomyomatous proliferations of the oral mucosa that contain an adipocytic component as analogous to classic renal AMLs although they differ significantly in their immunohistochemical phenotype. Herein, through review of the pertinent oral pathology literature and the detailed description of 2 lesions, one an oral angiomyoma with an adipocytic component and the other an apparently hamartomatous angioleiomyomatous proliferation with adipocytes, we provide, in our opinion, a solid argument against the use of the term AML for non-PEComatous oral tumors.
Tosios
Konstantinos I
KI
Department of Oral Pathology and Surgery, Dental School, National and Kapodistrian University of Athens, Greece.
Koutlas
Ioannis G
IG
Kyriakopoulos
Vasileios F
VF
Balta
Maria
M
Theologie-Lygidakis
Nandia
N
Vardas
Emmanuel
E
Iatrou
Ioannis
I
D000199:Actins / Q000032:analysis; D017667:Adipocytes / Q000473:pathology; D000368:Aged; D018207:Angiomyolipoma / Q000145:classification* / Q000473:pathology; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009062:Mouth Neoplasms / Q000145:classification* / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D009626:Terminology as Topic; D055815:Young Adult; D014841:von Willebrand Factor / Q000032:analysis
D000199:Actins; D003893:Desmin; D009418:S100 Proteins; D014841:von Willebrand Factor