[New polymer-drug systems based on natural and synthetic polymers].
The great versatility of polymers makes them very useful in the biomedical and pharmaceutical fields. The combination of natural and synthetic polymers leads to new materials with tailored functional properties. The aim of this work consists in the preparation of new drug delivery system based on chitosan (natural polymer) and polybetaines (synthetic polymers), by a simple process, well known in the literature as complex coacervation methods. Also, the adsorption and release studies of two antibiotics as well as the preservation of their bactericidal capacities were performed.
Racoviţă
Stefania
S
Institutul de Chimie Macromoleculaă Petru Poni Iaşi, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină Dentară.
Vasiliu
Silvia
S
Foia
Liliana
L
D019342:Acetic Acid / Q000138:chemical synthesis; D000179:Acrylates / Q000138:chemical synthesis*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001622:Betaine / Q000138:chemical synthesis*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001704:Biopolymers / Q000096:biosynthesis; D048271:Chitosan / Q000138:chemical synthesis*; D016503:Drug Delivery Systems / Q000379:methods; D006851:Hydrochloric Acid / Q000138:chemical synthesis; D008082:Lipotropic Agents / Q000138:chemical synthesis*; D014014:Tissue Adhesives / Q000138:chemical synthesis*
D000179:Acrylates; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D001704:Biopolymers; D008082:Lipotropic Agents; D014014:Tissue Adhesives; D001622:Betaine; D048271:Chitosan; C036658:acrylic acid; D019342:Acetic Acid; D006851:Hydrochloric Acid