Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma.
Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.
Ly
Tina
T
Ophthalmology & Vision Sciences, Laboratory Medicine & Pathobiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Gupta
Neeru
N
Weinreb
Robert N
RN
Kaufman
Paul L
PL
Yücel
Yeni H
YH
D000818:Animals; D003712:Dendrites / Q000473:pathology*; D004195:Disease Models, Animal; D005829:Geniculate Bodies / Q000378:metabolism / Q000473:pathology*; D005901:Glaucoma / Q000473:pathology*; D007150:Immunohistochemistry; D008252:Macaca fascicularis / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009474:Neurons / Q000473:pathology
D008869:Microtubule-Associated Proteins