title: Graft-induced dyskinesias in Parkinson's disease: what is it all about?
abstract: The treatment of Parkinson's disease with grafts of fetal ventral mesencephalic tissue has shown some success, but can result in graft-induced dyskinesias (GIDs). Recently in Science Translational Medicine, Politis et al. (2010) demonstrate that GIDs may originate from serotoninergic neurons that are cografted in these transplants.
authors.affiliation: Brain Repair Centre and Department of Neurology, University of Cambridge, Cambridge CB2 0PY, UK. rab46@cam.ac.uk
authors.forename: Roger A
authors.initials: RA
authors.lastname: Barker
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Kuan
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation / Q000009:adverse effects*; D002065:Buspirone / Q000627:therapeutic use; D020820:Dyskinesias / Q000188:drug therapy / Q000209:etiology*; D016332:Fetal Tissue Transplantation / Q000009:adverse effects*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications* / Q000601:surgery*; D012701:Serotonin / Q000378:metabolism; D033581:Stem Cell Transplantation
chemical_list: D012701:Serotonin; D002065:Buspirone