[Bronchiolitis and pulmonary hypertension].
OBJECTIVE
The study was undertaken to assess whether previously healthy infants with bronchiolitis develop elevated pulmonary artery pressures.


METHODS
We performed 2D and Doppler echocardiography in 94 infants, aged between 2 and 12 months, from November 2007 to December 2009. 47 infants had bronchiolitis and 47 were in the control group. We excluded children with congenital heart diseases and other conditions associated with pulmonary hypertension. The method of time to peak velocity corrected for heart rate was used to estimate pulmonary arterial pressure (PAP). A Student's t-test for independent samples was used to compare the mean values of variables.


RESULTS
Increased mean pulmonary pressures (> 25 mmHg) were measured in 13 infants with bronchiolitis. The values were categorized as mild-moderate pulmonary hypertension. Mean PAP were significantly increased in subjects with bronchiolitis, vs. control (p = 0.001). In infants with bronchiolitis, hospitalisation was significantly longer at patients with pulmonary hypertension vs. normal PAP (p = 0.006). Mean PAP were significantly increased in subjects with a moderate/severe episode of wheezing at admission vs. a mild episode (p = 0.001).


CONCLUSIONS
Echocardiography brings valuable informations regarding pulmonary hypertension in bronchiolitis. PHT could be a criterion in establishing the severity of disease, a prognosis factor and an element of therapeutic guidance.
Bardi-Peti
Luiza
L
Universitatea de Medicină si Farmacie "Carol Davila", S.C.U.C. "Grigore Alexandrescu", Bucureşti. luizabardi@yahoo.com
Ciofu
Eugen Pascal
EP
D001988:Bronchiolitis / Q000150:complications* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology*; D007223:Infant; D007902:Length of Stay; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012135:Respiratory Sounds / Q000209:etiology; D012720:Severity of Illness Index