title: Delayed akinetic catatonic mutism following methadone overdose.
abstract: A 49-year-old woman developed a catatonic mute state a few weeks after methadone overdose. Clinical, radiological and histological findings were consistent with toxic spongiform leukoencephalopathy, which adds a potentially deadly side-effect to a generally considered safe substitution for heroin.
authors.affiliation: Department of Neurology, UZ Brussel, Laarbeeklaan 101, Jette, Belgium. sgheuens@bidmc.harvard.edu
authors.forename: Sarah
authors.initials: S
authors.lastname: Gheuens
authors.forename: Alex
authors.initials: A
authors.lastname: Michotte
authors.forename: Anja
authors.initials: A
authors.lastname: Flamez
authors.forename: Jacques
authors.initials: J
authors.lastname: De Keyser
mesh_terms: D000405:Akinetic Mutism / Q000139:chemically induced* / Q000175:diagnosis*; D002389:Catatonia / Q000139:chemically induced* / Q000175:diagnosis*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced / Q000175:diagnosis; D008691:Methadone / Q000506:poisoning*; D013997:Time Factors
chemical_list: D008691:Methadone