title: The correlation between CVR-R and carotid atherosclerosis in type 2 diabetes mellitus patients with diabetic neuropathy.
abstract: We examined the relationship between the coefficient of variation in the R-R intervals (CVR-R) using electrocardiograms and the ultrasonic intima-media thickness (IMT) of the carotid artery, an atherosclerotic parameter, in type 2 diabetes mellitus (DM) patients with diabetic neuropathy (n=47, males/females: 29/18; mean age: 62 years). In this study, the CVR-R-related indexes, including CVR-R at rest (CVR-R(rest)), CVR-R with deep breaths (CVR-R(breath)) and their difference (CVR-R(breath) minus CVR-R(rest): CVR-R(dif)), were defined. Data such as body mass index, smoking habits, hemoglobin A1c, blood pressure, and serum low-density lipoprotein were collected. A significant inverse correlation was observed between max-IMT and CVR-R(dif) (beta=-0.34, p=0.042), but not CVR-R(rest) or CVR-R(breath), in multivariate analyses adjusted for all the data. Therefore, the CVR-R(dif) may serve as a clinical index for the diabetic autonomic neuropathy-atherosclerosis relation in type 2 DM patients.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yagyu
authors.forename: Harumi
authors.initials: H
authors.lastname: Koibuchi
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Fujii
authors.forename: Kei
authors.initials: K
authors.lastname: Konno
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamada
authors.forename: Shun
authors.initials: S
authors.lastname: Ishibashi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography