Association to the Glypican-5 gene in multiple sclerosis.
Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.
Lorentzen
Aslaug R
AR
Department of Neurology, Oslo University Hospital, Ullevål, University of Oslo, Oslo, Norway. aslaug.r.lorentzen@gmail.com
Melum
Espen
E
Ellinghaus
Eva
E
Smestad
Cathrine
C
Mero
Inger-Lise
IL
Aarseth
Jan H
JH
Myhr
Kjell-Morten
KM
Celius
Elisabeth G
EG
Lie
Benedicte A
BA
Karlsen
Tom H
TH
Franke
Andre
A
Harbo
Hanne F
HF
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D053673:Glypicans / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D009664:Norway; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
D053673:Glypicans