title: Second conservative treatment for ipsilateral breast cancer recurrence using high-dose rate interstitial brachytherapy: preliminary clinical results and evaluation of patient satisfaction.
abstract: OBJECTIVE
  To assess early clinical results and evaluate patient satisfaction in case of second conservative treatment (2nd CT) combining lumpectomy plus high-dose rate (HDR) interstitial brachytherapy for patients (pts) presenting with ipsilateral breast cancer recurrence (IBCR).
  
  
  METHODS
  From June 2005 to July 2009, 42 pts presenting with an IBCR underwent a second lumpectomy with intraoperative implantation of plastic tubes in the tumor bed. After performing the dose distribution analysis on the postimplant CT scan, a total dose of 34 Gy in 10 fractions over 5 consecutive days was delivered. Toxicity evaluation was based on the Common Terminology Criteria for Adverse Events v3.0 criteria. Applying a visual analogic scale (VAS) analysis, patient satisfaction regarding cosmetic result and 2nd CT possibility was performed after the end of brachytherapy.
  
  
  RESULTS
  Median followup was 21 months (range, 6-50 months) and median age at the time of local recurrence was 65 years (range, 30-85 years). Median delay between primary and recurrence was 11 years (range, 1-35 years). Median recurrence tumor size was 12 mm (range, 2-30 mm). Median number of plastic tubes and planes were nine (range, 5-12) and two (range, 1-3), respectively. Median clinical target volume was 68 cc (range, 31.2-146 cc). Second local control rate was 97%. Twenty-two pts (60%) developed complications. Cutaneous and subcutaneous fibrosis was the most frequent side effect. Median VAS satisfaction score regarding cosmetic result was 7 of 10 (range, 4-9), whereas median VAS satisfaction score for 2nd CT was 10 of 10 (range, 8-10).
  
  
  CONCLUSIONS
  A 2nd CT for IBCR using high-dose rate brachytherapy seems feasible with encouraging results in terms of second local control with an acceptable toxicity. Patient satisfaction regarding the possibility of second breast preservation should be considered.
authors.affiliation: Department of Radiation Therapy, Antoine Lacassagne Cancer Center, Nice, France. jean-michel.hannoun-levi@nice.fnclcc.fr
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Hannoun-Levi
authors.forename: Joël
authors.initials: J
authors.lastname: Castelli
authors.forename: Adrien
authors.initials: A
authors.lastname: Plesu
authors.forename: Adel
authors.initials: A
authors.lastname: Courdi
authors.forename: Ines
authors.initials: I
authors.lastname: Raoust
authors.forename: Michel
authors.initials: M
authors.lastname: Lallement
authors.forename: Bernard
authors.initials: B
authors.lastname: Flipo
authors.forename: Francette
authors.initials: F
authors.lastname: Ettore
authors.forename: Claire
authors.initials: C
authors.lastname: Chapelier
authors.forename: Philippe
authors.initials: P
authors.lastname: Follana
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Ferrero
authors.forename: Andréa
authors.initials: A
authors.lastname: Figl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000706:statistics & numerical data*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000628:therapy*; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015412:Mastectomy, Segmental / Q000706:statistics & numerical data*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000628:therapy*; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D010865:Pilot Projects; D015995:Prevalence; D018570:Risk Assessment