title: Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting.
abstract: Hepatocelluar carcinoma (HCC) is the most common primary malignancy of the liver in adults and the third most common cause of cancer death worldwide. The incidence of HCC in the United States is rising steadily because of the prevalence of hepatitis C viral infection and other causes of hepatic cirrhosis. The majority of patients have underlying hepatic dysfunction, which complicates patient management and the search for safe and effective therapies. The Clinical Trials Planning Meeting (CTPM) in HCC was convened by the National Cancer Institute's Gastrointestinal Cancer Steering Committee to identify the key knowledge gaps in HCC and define clinical research priorities. The CTPM structured its review according to current evidence-based treatment modalities in HCC and prioritized the recommendations on the basis of the patient populations representing the greatest unmet medical need.
authors.affiliation: Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. thomasmb@musc.edu
authors.forename: Melanie B
authors.initials: MB
authors.lastname: Thomas
authors.forename: Deborah
authors.initials: D
authors.lastname: Jaffe
authors.forename: Michael M
authors.initials: MM
authors.lastname: Choti
authors.forename: Jacques
authors.initials: J
authors.lastname: Belghiti
authors.forename: Steven
authors.initials: S
authors.lastname: Curley
authors.forename: Yuman
authors.initials: Y
authors.lastname: Fong
authors.forename: Gregory
authors.initials: G
authors.lastname: Gores
authors.forename: Robert
authors.initials: R
authors.lastname: Kerlan
authors.forename: Phillipe
authors.initials: P
authors.lastname: Merle
authors.forename: Bert
authors.initials: B
authors.lastname: O'Neil
authors.forename: Ronnie
authors.initials: R
authors.lastname: Poon
authors.forename: Lawrence
authors.initials: L
authors.lastname: Schwartz
authors.forename: Joel
authors.initials: J
authors.lastname: Tepper
authors.forename: Francis
authors.initials: F
authors.lastname: Yao
authors.forename: Daniel
authors.initials: D
authors.lastname: Haller
authors.forename: Margaret
authors.initials: M
authors.lastname: Mooney
authors.forename: Alan
authors.initials: A
authors.lastname: Venook
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006287:Health Planning Guidelines; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome