The flavonoids luteolin and quercetagetin inhibit lipoteichoic acid actions on H9c2 cardiomyocytes.
Dental focal infections are infections in the mouth that cause subsequent infection and symptoms in other parts of the body. Dental conditions such as periodontitis have been associated with coronary heart disease. In this study, we investigated the effect of flavonoids on activation of mitogen-activated protein kinase (MAPK) family members, protein kinase B (AKT), and IL-1 beta expression by rat heart embryonic (H9c2) cells upon stimulation with LTA. Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Our findings indicate that flavonoids interfere with LTA signal transduction.
Gutiérrez-Venegas
Gloria
G
Laboratorio de Bioquímica, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México, México. gloria@fo.odonto.unam.mx
Bando-Campos
Carlos Giroshi
CG
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002460:Cell Line; D002867:Chromones / Q000494:pharmacology*; D047309:Flavones; D005491:Focal Infection, Dental / Q000201:enzymology / Q000276:immunology*; D019833:Genistein / Q000494:pharmacology; D053583:Interleukin-1beta / Q000032:analysis / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000276:immunology; D047311:Luteolin / Q000494:pharmacology*; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000201:enzymology; D010766:Phosphorylation / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000032:analysis / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D013682:Teichoic Acids / Q000037:antagonists & inhibitors* / Q000276:immunology
D000975:Antioxidants; D002867:Chromones; D047309:Flavones; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid; D011794:Quercetin; D019833:Genistein; D051057:Proto-Oncogene Proteins c-akt; D020928:Mitogen-Activated Protein Kinases; D047311:Luteolin; C079163:quercetagetin