title: Transfer of cholesterol by the NPC team.
abstract: The mechanisms of intracellular cholesterol transport are largely unknown. In this issue of Cell Metabolism, Wang et al. (2010) identify amino acid residues on the lumenal lysosomal protein Niemann-Pick C2 (NPC2) that are required for intralysosomal transfer of endocytosed cholesterol to membrane-bound NPC1 via a process that avoids movement of hydrophobic cholesterol through the aqueous phase.
authors.affiliation: Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2S2, Canada. jean.vance@ualberta.ca
authors.forename: Jean E
authors.initials: JE
authors.lastname: Vance