Nephroprotective activity of Prosthechea michuacana against cisplatin-induced acute renal failure in rats.
In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Results showed that treatment with cisplatin induced significant elevations in concentrations of blood urea and serum creatinine and in lipid peroxidation. Treatments with methanolic extract (200, 400 and 500 mg/kg) increased levels of biochemical markers of renal injury like reduced glutathione, glutathione S-transferase, and superoxide dismutase and inhibited the increases in blood urea and serum creatinine concentrations and lipid peroxidation induced by cisplatin. Hexane and chloroform extracts did not show any effect. The results obtained in the present study indicate that this orchid can be a potential source of natural nephroprotective activity.
Gutierrez
Rosa Martha Perez
RM
Department of Organic Chemistry, National Polytechnical Institute, Mexico, Federal District, Mexico. rmpg@prodigy.net.mx
Gomez
Yolanda Gomez Y
YG
Ramirez
Esther Bautista
EB
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D002945:Cisplatin / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D029595:Orchidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012076:Renal Agents / Q000008:administration & dosage*
D010936:Plant Extracts; D020011:Protective Agents; D012076:Renal Agents; D003404:Creatinine; D002945:Cisplatin