Effect of hydrophobic interaction cooperating with double Lewis acid activation in a zinc(II) phosphodiesterase mimic.
The novel dinuclear Zn(ii) complex (1) containing a beta-CD dimer could accelerate BNPP (a DNA substitute) hydrolysis more efficiently than catalyze HPNP (a RNA substitute) transesterification with different mechanisms involved; the beta-CDs played remarkably different roles.
Zhao
Meng
M
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Zhang
Li
L
Chen
Huo-Yan
HY
Wang
Han-Lu
HL
Ji
Liang-Nian
LN
Mao
Zong-Wan
ZW
D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry / Q000378:metabolism; D015032:Zinc / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D000143:Acids; D056831:Coordination Complexes; D010755:Organophosphates; D009943:Organophosphorus Compounds; D047392:beta-Cyclodextrins; D010727:Phosphoric Diester Hydrolases; D015032:Zinc; C031215:betadex