title: Synthesis and biological evaluation of oxoindolin-3-ylidene ethyl benzothiohydrazides as non-peptide TPO mimics.
abstract: A novel series of oxoindolin-3-ylidene ethyl benzohydrazides were designed, synthesized, and identified as small molecule agonists of thrombopoietin (TPO) receptor c-mpl. Sulfur-oxygen exchange in oxoindolin-3-ylidene ethyl benzohydrazides was found to improve their agonistic activities. Several oxoindolin-3-ylidene ethyl benzothiohydrazides have been identified as full agonists of c-mpl.
authors.affiliation: Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China. tangpc@shhrp.com
authors.forename: Peng Cho
authors.initials: PC
authors.lastname: Tang
authors.forename: He Jun
authors.initials: HJ
authors.lastname: Lu
authors.forename: Yi Qian
authors.initials: YQ
authors.lastname: Chen
authors.forename: Sheng Lan
authors.initials: SL
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry; D053628:Receptors, Thrombopoietin / Q000819:agonists
chemical_list: D007211:Indoles; D010455:Peptides; D053628:Receptors, Thrombopoietin