Lineage-specific expansion of DNA-binding transcription factor families.
DNA-binding domains (DBDs) are essential components of sequence-specific transcription factors (TFs). We have investigated the distribution of all known DBDs in more than 500 completely sequenced genomes from the three major superkingdoms (Bacteria, Archaea and Eukaryota) and documented conserved and specific DBD occurrence in diverse taxonomic lineages. By combining DBD occurrence in different species with taxonomic information, we have developed an automatic method for inferring the origins of DBD families and their specific combinations with other protein families in TFs. We found only three out of 131 (2%) DBD families shared by the three superkingdoms.
Charoensawan
Varodom
V
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. varodom@mrc-lmb.cam.ac.uk
Wilson
Derek
D
Teichmann
Sarah A
SA
D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000737:chemistry* / Q000145:classification* / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors; D004247:DNA