title: Design, synthesis and acaricidal activity of novel strobilurin derivatives containing pyrimidine moieties.
abstract: BACKGROUND
  The intermediate derivatisation method based on bioisosteric replacement led to the discovery of the lead strobilurin compound 5a. To produce new strobilurin analogues with improved activity, a series of substituted pyrimidines were synthesised and bioassayed.
  
  
  RESULTS
  The compounds were identified by (1)H NMR, IR, MS and elemental analysis. The highly active compound 5 g was studied by X-ray diffraction. Preliminary bioassays demonstrated that some of the title compounds exhibited excellent acaricidal activity against Tetranychus cinnabarinus (Boisd.) at 10 mg L(-1). The relationship between structure and acaricidal activity is reported.
  
  
  CONCLUSIONS
  The present work demonstrates that strobilurin derivatives containing pyrimidine moieties can be used as possible lead compounds for developing novel acaricides.
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry, Shenyang, China.
authors.forename: Bao-Shan
authors.initials: BS
authors.lastname: Chai
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Liu
authors.forename: Hui-Chao
authors.initials: HC
authors.lastname: Li
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: He
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Luo
authors.forename: Guang
authors.initials: G
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Jun-Biao
authors.initials: JB
authors.lastname: Chang
mesh_terms: D056810:Acaricides / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D007854:Lead / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008689:Methacrylates / Q000737:chemistry*; D010571:Pest Control; D011743:Pyrimidines / Q000737:chemistry; D040102:Tetranychidae
chemical_list: D056810:Acaricides; D008689:Methacrylates; D011743:Pyrimidines; D007854:Lead; C030986:pyrimidine