title: Comparison of the high relaxivity Gd chelates P1152 and Gd-BOPTA for contrast-enhanced MR angiography in rabbits at 1.5 Tesla and 3.0 Tesla.
abstract: OBJECTIVE
  To compare signal-enhancing properties of the high relaxivity Gd chelates P1152 and Gd-BOPTA for contrast-enhanced MR angiography (CE-MRA) in rabbits at 1.5 Tesla (T) and 3.0T.
  
  
  METHODS
  Three-dimensional CE-MRA of the abdominal vasculature was performed in six rabbits using both contrast agents at a dose of 0.1 mmol/kg. Data acquisition was carried out during first pass and up to 10 min after contrast material administration. CNR was determined in aorta, vena cava, and renal cortex. Image quality (5-point scale, 5 = best) of first pass MR angiograms was rated by two radiologists.
  
  
  RESULTS
  During first pass CNR of the aorta was 55.1 +/- 5.8 (P1152) and 40.3 +/- 3.9 (Gd-BOPTA) at 1.5T (P < 0.05), and 114.9 +/- 9.9 (P1152) and 73.5 +/- 8.1 (Gd-BOPTA) at 3.0T (P < 0.05). Both contrast agents showed a comparable decline of CNR within 10 min. Image quality was rated 4.8 +/- 0.40 (P1152) and 4.5 +/- 0.50 (Gd-BOPTA) at 1.5T (P = 0.17), and 4.8 +/- 0.37 (P1152) and 4.7 +/- 0.47 (Gd-BOPTA) at 3.0T (P = 0.61).
  
  
  CONCLUSIONS
  The high relaxivity Gd-chelate P1152 offers potential to improve image contrast for CE-MRA compared with a clinically approved high relaxivity contrast agent.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. k.peldschus@uke.uni-hamburg.de
authors.forename: Kersten
authors.initials: K
authors.lastname: Peldschus
authors.forename: Mareike
authors.initials: M
authors.lastname: Hamdorf
authors.forename: Philippe
authors.initials: P
authors.lastname: Robert
authors.forename: Marc
authors.initials: M
authors.lastname: Port
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Herborn
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D002614:Chelating Agents / Q000494:pharmacology*; D003287:Contrast Media / Q000494:pharmacology*; D056831:Coordination Complexes / Q000494:pharmacology*; D005260:Female; D007091:Image Processing, Computer-Assisted; D007672:Kidney Cortex / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014682:Vena Cava, Inferior / Q000473:pathology
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D056831:Coordination Complexes; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine