title: Confirmation rate of blinded (99m)Tc-SPECT compared to neurochemical dementia biomarkers in CSF in patients with Alzheimer disease.
abstract: In Alzheimer disease, CSF biomarkers and nuclear imaging are of particular interest. Many studies investigated only one technique, limiting comparison. Here, in 76 patients blinded 99mTc-SPECT was compared to CSF. Sensitivity of CSF was 92%; and 51% for SPECT. Specificity favored SPECT (90 vs. 80%). Both techniques showed no coherence (p = 0.17-0.47). Our results confirm that CSF biomarkers show higher sensitivity. SPECT has higher specificity and can also be used for other dementias without established CSF biomarkers.
authors.affiliation: Clinical Nuclear Medicine Unit, University of Erlangen-Nurenberg, Erlangen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Schmidt
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Gerd
authors.initials: G
authors.lastname: Schaller
authors.forename: Umüt
authors.initials: U
authors.lastname: Degirmenci
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kreil
authors.forename: Jens
authors.initials: J
authors.lastname: Wiltfang
authors.forename: Torsten
authors.initials: T
authors.lastname: Kuwert
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.forename: Markus
authors.initials: M
authors.lastname: Weih
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging* / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D053327:Apolipoprotein E4 / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins