Platelet morphological, functional and rheological properties attributable to addictions.
Hemorheological abnormalities such as elevated whole blood viscosity, plasma viscosity, erythrocyte deformability and platelet aggregation, hematocrit and fibrinogen levels, are frequently examined as diagnostic tool and prognostic relevance in socially important hemorheological disorders. Distinct biological - morphological and functional platelet alterations, have been described in different addictions (heroin-, cocaine-, nicotine-, alcohol-, etc.). Chronic addictions could cause biochemical and conformational changes in platelets and their membranes, thus modulating platelet receptor expression, morphology (anisocytosis, giant platelets) and activation (alpha-granule release), platelet aggregation and hemorheological properties. Some of these alterations in chronic addicts - documented at cellular- and molecular level, could be easily used as a precise diagnostic tool with regard to thromboembolic complications and microcirulation injuries attributable to addictions. The present review focuses on some changes in platelet morphological, functional and rheological properties induced by chronic opiate/opioid abuse. Hypothesis is accumulated that free fatty acids (FFAs) and especially oleic acid (OA) could cause positive molecular and conformational changes in platelets of addicts with hemorheological disorders.
Zvetkova
Elissaveta
E
Bulgarian Society of Biorheology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Antonova
Nadia
N
Ivanov
Ivan
I
Savov
Yonko
Y
Gluhcheva
Yordanka
Y
D001792:Blood Platelets / Q000473:pathology*; D005230:Fatty Acids, Nonesterified; D018056:Hemorheology; D006801:Humans; D008833:Microcirculation; D019301:Oleic Acid; D009293:Opioid-Related Disorders / Q000097:blood*; D019966:Substance-Related Disorders / Q000097:blood; D013923:Thromboembolism / Q000175:diagnosis / Q000209:etiology
D005230:Fatty Acids, Nonesterified; D019301:Oleic Acid