Design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]choline and [(11)C]methionine with radiopharmaceutical quality.
We herein describe the design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]methionine and [(11)C]choline for human use. Kits were designed for maximal simplicity and ease of using modules from Eckert & Ziegler Modular Lab System. The use of all-disposable sterile medical-grade material, helps ensure safety and cGMP compliance. The quick set-up and removal ("plug & play") also reduces radiation burden to operator.
Quincoces
Gemma
G
Radiopharmacy Unit, Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av. Pío XII 36, 31008 Pamplona, Spain. gquinfer@unav.es
López-Sánchez
Luisa
L
Sánchez-Martínez
María
M
Rodríguez-Fraile
Macarena
M
Peñuelas
Iván
I
D001331:Automation; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000138:chemical synthesis*; D008715:Methionine / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline