title: Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.
abstract: In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-Ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirm that the "small molecule" co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, Laboratory for Bioorganic Chemistry.
authors.forename: Pavel
authors.initials: P
authors.lastname: Nagorny
authors.forename: Isaac
authors.initials: I
authors.lastname: Krauss
authors.forename: Jón T
authors.initials: JT
authors.lastname: Njardarson
authors.forename: Lucy
authors.initials: L
authors.lastname: Perez
authors.forename: Christoph
authors.initials: C
authors.lastname: Gaul
authors.forename: Guangli
authors.initials: G
authors.lastname: Yang
authors.forename: Ouathek
authors.initials: O
authors.lastname: Ouerfelli
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky