title: Fiber-optic probes for in vivo depth-resolved neuron-activity mapping.
abstract: Specialty fiber probes are used for in vivo depth-resolved mapping of neuron activity through the optical detection of fluorescent-protein reporters expressed inside the living brain of anesthetized transgenic mice. Supercontinuum radiation produced by highly nonlinear photonic-crystal fibers is employed to demonstrate a simultaneous multicolor interrogation of several biomarkers in a model aqueous solution system, thus suggesting the way toward a multiplex mapping of various types of neuron dynamics inside the living brain.
authors.affiliation: Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Russia.
authors.forename: Lyubov V
authors.initials: LV
authors.lastname: Doronina-Amitonova
authors.forename: Il'ya V
authors.initials: IV
authors.lastname: Fedotov
authors.forename: Olga I
authors.initials: OI
authors.lastname: Ivashkina
authors.forename: Marina A
authors.initials: MA
authors.lastname: Zots
authors.forename: Andrei B
authors.initials: AB
authors.lastname: Fedotov
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Anokhin
authors.forename: Aleksei M
authors.initials: AM
authors.lastname: Zheltikov
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000166:cytology / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D057054:Molecular Imaging / Q000295:instrumentation*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D055100:Optical Fibers; D055620:Optical Phenomena; D017785:Photons
chemical_list: D015415:Biomarkers; D049452:Green Fluorescent Proteins