title: Psychosocial adjustment in children and adolescents with a parent with multiple sclerosis: a systematic review.
abstract: OBJECTIVE
  This systematic review explored the potential impact of parental multiple sclerosis on their offspring. It considered adjustment to parental multiple sclerosis at different developmental stages and the factors associated with good versus poor adjustment.
  
  
  METHODS
  MEDLINE, EMBASE, PsycINFO, CINAHL and Web of Science were searched for studies on children with a parent with multiple sclerosis. Inclusion and exclusion criteria were formulated. Hand-searching journals and reference lists, contacting authors and multiple sclerosis societies for additional unpublished papers complemented the searches.
  
  
  METHODS
  Twenty studies that satisfied the inclusion criteria were included. The research articles were ranked according to a quality assessment checklist and were categorized as good, medium or poor quality.
  
  
  RESULTS
  The review found good evidence to suggest that parental multiple sclerosis has a negative impact on children's social and family relationships and their psychological well-being. The review also identified potential factors associated with poor adjustment. These factors included parental negative emotions, increased illness severity, family dysfunction, children's lack of knowledge about the illness and lack of social support. Adolescent children also seemed to be more at risk for psychosocial problems than school-age children.
  
  
  CONCLUSIONS
  There is good evidence that parental multiple sclerosis has a negative psychosocial impact on children, especially on adolescents.
authors.affiliation: University of Southampton, School of Psychology, Southampton, UK. ab2406@soton.ac.uk
authors.forename: Angeliki
authors.initials: A
authors.lastname: Bogosian
authors.forename: Rona
authors.initials: R
authors.lastname: Moss-Morris
authors.forename: Julie
authors.initials: J
authors.lastname: Hadwin
mesh_terms: D000223:Adaptation, Psychological; D000275:Adjustment Disorders; D000293:Adolescent; D002648:Child; D005191:Family Characteristics; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000523:psychology*; D010290:Parents