title: Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations.
abstract: We report the clinical features of the original Chilean family with Kufor-Rakeb syndrome (KRS) that led to the discovery of the ATP13A2 gene at the PARK9 locus. KRS is a rare juvenile-onset autosomal recessive disease characterized by progressive Parkinsonism, pyramidal signs, and cognitive decline in addition to vertical gaze palsy and facial-faucial-finger minimyoclonus. Neurological and neuropsychological examination during a 10-year period, videotaping, neuroimaging, and measurement of DNA methylation of the ATP13A2 promoter region were performed. The youngest 5 of 17 children of nonconsanguineous parents, carrying compound-heterozygous ATP13A2 mutations, had normal development until ages ∼10 to 12 years, when school performance deteriorated and slowness, rigidity, and frequent falls developed. Examination revealed bradykinesia, subtle postural/action tremor, cogwheel rigidity, spasticity, upward gaze palsy, smooth pursuit with saccadic intrusions, and dementia. Additional signs included facial-faucial-finger minimyoclonus, absent postural reflexes, visual/auditory hallucinations, and insomnia. Levodopa response could not be fully judged in this family. T2* magnetic resonance imaging sequences revealed marked diffuse hypointensity of the caudate (head and body) and lenticular nucleus bilaterally. Disease progression was slow including epilepsy, cachexia, and anarthria. Four affected members died after 28.5 ± 5.5 (mean ± SD) years of disease. Two heterozygous carriers, the mother and eldest sibling, showed jerky perioral muscle contractions and clumsiness of hand movements. There was no significant correlation between DNA methylation of the ATP13A2 promoter region and disease progression. The marked caudate and lenticular nucleus T2*-hypointensity suggests that KRS might belong to the family of neurodegenerative diseases associated with brain iron accumulation.
authors.affiliation: Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago, Chile. mbehrens@redclinicauchile.cl
authors.forename: Maria I
authors.initials: MI
authors.lastname: Behrens
authors.forename: Norbert
authors.initials: N
authors.lastname: Brüggemann
authors.forename: Pedro
authors.initials: P
authors.lastname: Chana
authors.forename: Pablo
authors.initials: P
authors.lastname: Venegas
authors.forename: Marianne
authors.initials: M
authors.lastname: Kägi
authors.forename: Teresa
authors.initials: T
authors.lastname: Parrao
authors.forename: Patricia
authors.initials: P
authors.lastname: Orellana
authors.forename: Cristian
authors.initials: C
authors.lastname: Garrido
authors.forename: Cecilia V
authors.initials: CV
authors.lastname: Rojas
authors.forename: Jan
authors.initials: J
authors.lastname: Hauke
authors.forename: Eric
authors.initials: E
authors.lastname: Hahnen
authors.forename: Rafael
authors.initials: R
authors.lastname: González
authors.forename: Nicolas
authors.initials: N
authors.lastname: Seleme
authors.forename: Verónica
authors.initials: V
authors.lastname: Fernández
authors.forename: Alexander
authors.initials: A
authors.lastname: Schmidt
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Binkofski
authors.forename: Detlef
authors.initials: D
authors.lastname: Kömpf
authors.forename: Christian
authors.initials: C
authors.lastname: Kubisch
authors.forename: Johann
authors.initials: J
authors.lastname: Hagenah
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ramirez
mesh_terms: D017668:Age of Onset; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002677:Chile; D019175:DNA Methylation; D018450:Disease Progression; D005820:Genetic Testing; D006801:Humans; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D010375:Pedigree; D011401:Promoter Regions, Genetic; D006180:Proton-Translocating ATPases / Q000235:genetics*
chemical_list: C514983:ATP13A2 protein, human; D006180:Proton-Translocating ATPases