Overall diet history and reversibility of the metabolic syndrome over 5 years: the Whitehall II prospective cohort study.
OBJECTIVE
We examined the impact of adherence to the Alternative Healthy Eating Index (AHEI), a set of dietary guidelines targeting major chronic diseases, on metabolic syndrome (MetS) reversion in a middle-aged population.


METHODS
Analyses were carried out on the 339 participants (28% women, mean age 56.4 years) from the Whitehall II study with MetS as defined by the National Cholesterol Education Program Adult Treatment Panel III criteria. Reversion was defined as not having MetS after 5 years of follow-up (158 case subjects).


RESULTS
After controlling for potential confounders, adherence to AHEI was associated with MetS reversion (odds ratio 1.88 [95% CI 1.04-3.41]), predominantly in participants with central obesity and in those with high triglyceride.


CONCLUSIONS
Our findings support the benefit of adherence to AHEI dietary guidelines for individuals with MetS, especially those with central obesity or high triglyceride levels.
Akbaraly
Tasnime N
TN
Department of Epidemiology and Public Health, University College London, London, UK. tasnime.akbaraly@inserm.fr
Singh-Manoux
Archana
A
Tabak
Adam G
AG
Jokela
Markus
M
Virtanen
Marianna
M
Ferrie
Jane E
JE
Marmot
Michael G
MG
Shipley
Martin J
MJ
Kivimaki
Mika
M
D004032:Diet; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D011446:Prospective Studies