title: Stem cell therapy in chronic ischemic heart dysfunction with and without viability.
abstract: A growing number of clinical trials are evaluating the effects of stem cell therapy in patients with chronic ischemic heart dysfunction. As most of the clinical trials included a limited and different number of patients, various stem cell sources and several delivery approaches, results vary substantially between these studies. We analyse whether the assessment of myocardial viability may be important when evaluating effects of stem cell transplantation on parameters of left ventricular remodeling. Viability assessment could help to find the best type of stem cell and the best method of cell delivery to be used in chronic ischemic heart dysfunction.
authors.affiliation: Cardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Sánchez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sanz-Ruiz
authors.forename: M Eugenia
authors.initials: ME
authors.lastname: Fernández-Santos
authors.forename: Adolfo
authors.initials: A
authors.lastname: Villa
authors.forename: Enrique
authors.initials: E
authors.lastname: Gutiérrez
authors.forename: Lucia
authors.initials: L
authors.lastname: Fernández
authors.forename: Sandra
authors.initials: S
authors.lastname: Vázquez
authors.forename: M José
authors.initials: MJ
authors.lastname: Lorenzo
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Avilés
mesh_terms: D002470:Cell Survival / Q000502:physiology; D002908:Chronic Disease; D006333:Heart Failure / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D017202:Myocardial Ischemia / Q000473:pathology* / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000473:pathology; D016896:Treatment Outcome; D020257:Ventricular Remodeling