title: Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL).
abstract: 'Splenic red pulp lymphoma with numerous basophilic villous lymphocytes' (SRPL), recently described, is characterized by clinical, morphologic, immunologic, cytogenetic and molecular features distinct from SMZL/SLVL and HCL. In particular, the intensity of CD11c staining (expressed as fluorescence intensity -RFI-) in SRPL is significantly different from the RFI in SMZL/SLVL and HCL. Moreover the use of a scoring system based on the expression of CD11c, CD22, CD76, CD38 and CD27 appears to improve the differential diagnosis between SRPL and SMZL/SLVL and emphasizes that SRPL is an entity closed to but distinct from SMZL/SLVL.
authors.affiliation: Laboratoire d'Hématologie cellulaire, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 69495 Pierre Bénite, France.
authors.forename: L
authors.initials: L
authors.lastname: Baseggio
authors.forename: A
authors.initials: A
authors.lastname: Traverse-Glehen
authors.forename: E
authors.initials: E
authors.lastname: Callet-Bauchu
authors.forename: D
authors.initials: D
authors.lastname: Morel
authors.forename: J P
authors.initials: JP
authors.lastname: Magaud
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.forename: G
authors.initials: G
authors.lastname: Salles
authors.forename: P
authors.initials: P
authors.lastname: Felman
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D039521:CD11c Antigen / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D013160:Splenic Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D039521:CD11c Antigen