title: Exforge (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact.
abstract: BACKGROUND
  Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed.
  
  
  OBJECTIVE
  This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least two antihypertensive agents are often needed to achieve blood pressure control. Exforge((R)) (Novartis) is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan.
  
  
  METHODS
  The amlodipine/valsartan combination is an association of two well-known antihypertensive products with specific targets in cardiovascular protection, namely calcium channel blockade and antagonism of the renin-angiotensin-aldosterone system. This kind of association, with neutral metabolic properties and significant antihypertensive efficacy, could be a useful new antihypertensive product. Currently available data have shown that this new combination is well-tolerated and effective even in severe hypertension.
  
  
  CONCLUSIONS
  Clinical trials are ongoing for further assessment of the efficacy, compliance, and safety of this combination and its congeners. No data exist to prove that the amlodipine/valsartan combination is better than other antihypertensive strategies for cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage.
authors.affiliation: Division of Nephrology/Transplantation, University of Liège - Sart Tilman, Belgium;
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.forename: Eric P
authors.initials: EP
authors.lastname: Cohen