Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.
Three new 5-carbon-linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin in only 3-steps and 40-50% overall yields. Each one of these new chemical entities is at least as efficacious as the clinically used trioxane antimalarial drug artemether when combined with mefloquine hydrochloride in a low single oral dose cure.
Moon
Deuk Kyu
DK
Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218.
Singhal
Vandana
V
Kumar
Nirbhay
N
Shapiro
Theresa A
TA
Posner
Gary H
GH