Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions.
BACKGROUND
The current paradigm for cord blood transplantation is that HLA matching and immune suppression are strictly required to prevent graft versus host disease (GVHD). Immunological arguments and historical examples have been made that the use of cord blood for non-hematopoietic activities such as growth factor production, stimulation of angiogenesis, and immune modulation may not require matching or immune suppression.


METHODS
114 patients suffering from non-hematopoietic degenerative conditions were treated with non-matched, allogeneic cord blood. Doses of 1-3 x 10(7) cord blood mononuclear cells per treatment, with 4-5 treatments both intrathecal and intravenously were performed. Adverse events and hematological, immunological, and biochemical parameters were analyzed for safety evaluation.


RESULTS
No serious adverse effects were reported. Hematological, immunological, and biochemical parameters did not deviate from normal ranges as a result of therapy.


CONCLUSIONS
The current hematology-based paradigm of need for matching and immune suppression needs to be revisited when cord blood is used for non-hematopoietic regenerative purposes in immune competent recipients.
Yang
Wan-Zhang
WZ
Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, China.
Zhang
Yun
Y
Wu
Fang
F
Min
Wei-Ping
WP
Minev
Boris
B
Zhang
Min
M
Luo
Xiao-Ling
XL
Ramos
Famela
F
Ichim
Thomas E
TE
Riordan
Neil H
NH
Hu
Xiang
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000097:blood / Q000276:immunology / Q000628:therapy*; D014184:Transplantation, Homologous / Q000009:adverse effects; D055815:Young Adult