Pd-catalyzed carbonylative conjugate addition of dialkylzinc reagents to unsaturated carbonyls.
The Pd-catalyzed addition of organozinc reagents to unsaturated carbonyls in the presence of carbon monoxide provides 1,4-diketones in good yield. The reaction was studied with a number of substituted cyclic and acyclic ketones as well as alpha,beta-unsaturated aldehydes.
Custar
Daniel W
DW
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
Le
Hai
H
Morken
James P
JP
D000447:Aldehydes / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D000447:Aldehydes; D007202:Indicators and Reagents; D007659:Ketones; D009942:Organometallic Compounds; D010165:Palladium; D002248:Carbon Monoxide; D015032:Zinc