[Comparison of pharmacological effects of Fructus Mume and its processed products].
OBJECTIVE
To compare the pharmacological effects of Fructus Mume and its processed products, to investigate pharmacologic relation among Fructus Mume, malic acid, citric acid.


METHODS
Blood glucose from orbital sinus was measured to observe the effects of Fructus Mume, Fructus Mume sarcocarp and Fructus Mume carbon, malic acid, citric acid on blood glucose level of normal mice. The efficacy of drugs above on gastrointestinal motility was investigated through coated charcoal method in small intestinal propulsive motion in mice. Antimicrobial spectrum and minimal inhibitory concentrations for drugs were obtained by antimicrobial tests in vitro.


RESULTS
Fructus Mume, Fructus Mume sarcocarp, Fructus Mume carbon and malic acid could enhance intestinal propulsive motion and motility in percentage. Fructus Mume sarcocarp and Fructus Mume carbon, malic acid and citric acid could reduce the level of blood glucose in normal mice. Fructus Mume, Fructus Mume sarcocarp and Fructus Mume carbon, citric acid and malic acid showed an inhibitory effect on growth of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Monilia albican to a certain extent.


CONCLUSIONS
Pharmacological functions of Fructus Mume are not exactly the same with its products. Thus, in order to achieve safety during drug application, they should be administrated base on diagnosis. Because malic acid and citric acid in Fructus Mume show a correlation with its pharmacological actions, they can be used as parameters for quality control standard.
Wang
Lu
L
Yun Nan Institute for Food and Drug Control, Kunming 650031, China. wanglu6688@126.com
Zhang
Hong-Yu
HY
Wang
Li
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects*; D019343:Citric Acid / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006358:Hot Temperature; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects; D008293:Malates / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010598:Pharmacognosy; D010946:Plants, Medicinal / Q000737:chemistry; D027861:Prunus / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D008293:Malates; D019343:Citric Acid; C030298:malic acid