The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship.
We found renin inhibitory activity in rice. The physico-chemical data on the isolated inhibitors were identical to those of oleic acid and linoleic acid. Oleic acid and linoleic acid competitively inhibited renin activity, with K(i) values of 15.8 and 19.8 microM respectively. Other unsaturated free fatty acids also inhibited renin activity, but saturated fatty acids had no effect on it.
Takahashi
Saori
S
Akita Research Institute of Food and Brewing, Sanuki, Arayamachi, Akita, Japan. saori@arif.pref.akita.jp
Tokiwano
Tetsuo
T
Hata
Keishi
K
Kodama
Ikuko
I
Hokari
Mika
M
Suzuki
Nao
N
Yoshizawa
Yuko
Y
Gotoh
Takeshi
T
D020128:Inhibitory Concentration 50; D019787:Linoleic Acid / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019301:Oleic Acid / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012275:Oryza / Q000737:chemistry*; D011480:Protease Inhibitors / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D000092502:Renin Inhibitors
D019787:Linoleic Acid; D019301:Oleic Acid; D011480:Protease Inhibitors; D000092502:Renin Inhibitors