title: Application of an immobilised amylose-based chiral stationary phase to the development of new monoamine oxidase B inhibitors.
abstract: A direct HPLC enantioseparation of three new chiral oxadiazoline derivatives endowed with potential MAO-B inhibitory activity was accomplished on the immobilised Chiralpak IA chiral stationary phase. Multi-mg amounts of enantiomers with high enantiomeric purity (ee> or =98%) were rapidly collected using pure dichloromethane as eluent. The absolute configuration and chiroptical properties of the enantiomers isolated at semipreparative scale were exhaustively determined.
authors.affiliation: Istituto Superiore di Sanità, Dipartimento del Farmaco, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Sanna
authors.forename: Elias
authors.initials: E
authors.lastname: Maccioni
authors.forename: Sara
authors.initials: S
authors.lastname: Vigo
authors.forename: Cristina
authors.initials: C
authors.lastname: Faggi
authors.forename: Roberto
authors.initials: R
authors.lastname: Cirilli
mesh_terms: D000688:Amylose / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D010069:Oxadiazoles / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010069:Oxadiazoles; D000688:Amylose; D008995:Monoamine Oxidase