title: Relationships between structures of hydroxyflavones and their antioxidative effects.
abstract: Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3',4'-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure-activity relationships were examined.
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Jiye
authors.initials: J
authors.lastname: Hyun
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Woo
authors.forename: Do-Seok
authors.initials: DS
authors.lastname: Hwang
authors.forename: Geunhyeong
authors.initials: G
authors.lastname: Jo
authors.forename: Sunglock
authors.initials: S
authors.lastname: Eom
authors.forename: Younggiu
authors.initials: Y
authors.lastname: Lee
authors.forename: Jun Cheol
authors.initials: JC
authors.lastname: Park
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D044948:Flavonols; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D047309:Flavones; D005419:Flavonoids; D044948:Flavonols; D016166:Free Radical Scavengers; C037032:galangin; C017875:fisetin