[Effect of n-3 fatty acids in glycemic and lipid profiles, oxidative stress and total antioxidant capacity in patients with the metabolic syndrome].
OBJECTIVE
Metabolic syndrome (MS) is a cluster of factors which favors the development of cardiovascular diseases. Previous studies have shown that polyunsaturated fatty acids (PUFAs) can improve some of these factors. This study aimed to evaluate the effect of fish oil on glucose and lipid profiles, oxidative stress and total antioxidant capacity (TRAP) in patients with MS.


METHODS
We conducted a clinical trial in 40 patients with the MS (20 controls and 20 patients receiving 3 g/day of PUFAs).


RESULTS
The group that received treatment showed a significant decrease in levels of triglycerides and increased in TRAP, but they had a significant increase in LDL, glucose and insulin resistance.


CONCLUSIONS
We conclude that intake of fish oil resulted in decreased levels of triglycerides and increased the TRAP of patients with MS; however, increased LDL levels and insulin resistance, were observed.
Simão
Andréa Name Colado
AN
Departamento de Patologia, Centro de Ciências da Saúde, Universidade Estadual de Londrina, PR, Brasil. deianame@yahoo.com.br
Godeny
Paula
P
Lozovoy
Marcell Alysson Batisti
MA
Dichi
Jane Bandeira
JB
Dichi
Isaias
I
D000975:Antioxidants / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis*; D001837:Body Weights and Measures; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol