[Immunobiologically active compounds from skin].
This paper describes physiochemical and biological properties of 3 immunologically active compounds extracted by acetone from porcine skin. High pressure gel chromatography confirmed their heterogeneity. RP-HPLC of compound 2 (C2 or K-activin) also characterizes it as a heterogeneous entity. It was shown to inhibit proliferation of cultured fibroblasts from human fetuses and exhibit weak activity in general anaphylactic reaction (anaphylactic shock) and skin anaphylactic reaction. A summary of data on immunologically active compounds are presented with special emphasis laid on acetone-extractable K-activin.
Belova
O V
OV
Arion
V Ia
VIa
Lopukhin
Iu M
IuM
Martynov
A K
AK
Artemkina
I V
IV
Korotkova
M N
MN
Orlova
V F
VF
Skoptsova
S V
SV
D000096:Acetone; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D001685:Biological Factors / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D012867:Skin / Q000737:chemistry* / Q000187:drug effects / Q000276:immunology; D012997:Solvents; D013552:Swine
D001685:Biological Factors; D012997:Solvents; D000096:Acetone