A case of anaphylaxis to oral minocycline.
Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. To date, there has been only one case report of anaphylaxis to minocycline. We report here a case of anaphylaxis to oral minocycline. A 56-yr-old woman visited our hospital after three episodes of recurrent anaphylaxis. We performed an oral challenge test, the standard method for diagnosing drug allergies, with minocycline, one of the drugs she had taken previously. She developed urticaria, angioedema, nausea, vomiting, hypotension, and dyspnea within 4 min and was treated with intramuscular epinephrine, intravenous antihistamine and systemic corticosteroid. However, she presented similar symptoms at 50 min and at 110 min. In prescribing oral minocycline, physicians should consider the possibility of serious adverse reactions, such as anaphylaxis.
Jang
Ji Woong
JW
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Bae
Yun-Jeong
YJ
Kim
Yong Giun
YG
Jin
Young-Joo
YJ
Park
Kyung Sun
KS
Cho
You Sook
YS
Moon
Hee-Bom
HB
Kim
Tae-Bum
TB
D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D012008:Recurrence
D000900:Anti-Bacterial Agents; D008911:Minocycline