title: Ezrin immunoreactivity in renal cell carcinomas.
abstract: OBJECTIVE
  To determine ezrin's association with clinicopathologic features and to investigate the possible effects of the presence of ezrin on the differential diagnosis of subtypes of renal cell carcinoma (RCC).
  
  
  METHODS
  Ezrin reactivity was examined immunohistochemically in tumor tissues obtained from 78 patients who underwent radical nephrectomy for renal cell carcinoma. Correlation between ezrin expression and RCC subtypes was investigated and compared with tumor stage, grade and other clinicopathologic parameters.
  
  
  RESULTS
  There was no correlation between ezrin expression and clinicopathologic features. Furthermore, a significant correlation was found between ezrin reactivity and subtypes of RCC (p = 0.002). Ezrin reactivity was observed mainly in conventional, papillary and mucinous tubular spindle cell carcinoma (MTSCC) subtypes of RCC, while none of the chromophobe RCC was positive for ezrin. Sarcomatoid and unclassified subtypes of RCC were found to be faint and/or negative for ezrin reactivity.
  
  
  CONCLUSIONS
  Investigation of ezrin reactivity may be beneficial as an additional diagnostic marker in the differential diagnosis of RCC subtypes. Also, it seems to be useful to designate the origin of MTSCC.
authors.affiliation: Department of Pathology, Medical Faculty, Dokuz Eylul University, Ismir, Turkey. burcin.tuna@deu.edu.tr
authors.forename: Burçin
authors.initials: B
authors.lastname: Tuna
authors.forename: Kutsal
authors.initials: K
authors.lastname: Yorukoglu
authors.forename: Roberta
authors.initials: R
authors.lastname: Mazzucchelli
authors.forename: Ugur
authors.initials: U
authors.lastname: Mungan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Secil
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Ziya
authors.initials: Z
authors.lastname: Kirkali
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000473:pathology; D019459:Urothelium / Q000378:metabolism / Q000473:pathology; D000099149:Ezrin
chemical_list: D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D000099149:Ezrin