title: A case of congenital central hypoventilation syndrome with PHOX2B gene mutation in a Korean neonate.
abstract: Congenital central hypoventilation syndrome (CCHS) is a life-threatening disorder with apnea and cyanosis during sleep requiring immediate endotracheal intubation during the first day of life. The PHOX2B gene has been identified as the major gene involved in CCHS. This is the first report of a Korean neonate with CCHS confirmed to have a PHOX2B mutation with expanded alleles containing 20 polyalanine repeats that is a relatively small number compared to previous cases. The patient required intermittent ventilator support during sleep only and did not suffer from any other disorders of the autonomic nerve system. He consistently needs ventilator support during sleep and remains alive. Analysis of PHOX2B gene is useful for diagnosis and appropriate therapeutic intervention of CCHS patients.
authors.affiliation: Department of Pediatrics, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Kyoung-Ah
authors.initials: KA
authors.lastname: Kwon
authors.forename: Su-Eun
authors.initials: SE
authors.lastname: Park
authors.forename: Shin-Yun
authors.initials: SY
authors.lastname: Byun
authors.forename: Shine-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Sang-Hyoun
authors.initials: SH
authors.lastname: Hwang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007040:Hypoventilation / Q000151:congenital / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D010455:Peptides / Q000235:genetics; D056910:Republic of Korea; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000235:genetics*; D012122:Ventilators, Mechanical
chemical_list: D018398:Homeodomain Proteins; C109220:NBPhox protein; D010455:Peptides; D014157:Transcription Factors; C019529:polyalanine