Silver- and gold-mediated intramolecular cyclization to substituted tetracyclic isoquinolizinium hexafluorostilbates.
A convenient route for the synthesis of various charged tetracyclic isoquinolizinium hexafluorostilbates was developed using AgSbF(6)/AuCl(PPh(3)) for the intramolecular addition of amine to alkyne. The described process is tolerant of a variety of functional groups and broadens the diversity of substrates with the use of 8-substituted tetracyclic isoquinolizinium salts.
Liu
Fang
F
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Ding
Xiao
X
Zhang
Lei
L
Zhou
Yu
Y
Zhao
Linxiang
L
Jiang
Hualiang
H
Liu
Hong
H
D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000965:Antimony / Q000737:chemistry*; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D000588:Amines; D007546:Isoquinolines; D009942:Organometallic Compounds; D012834:Silver; D006046:Gold; D000965:Antimony