title: Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures.
abstract: Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received minocycline for at least 2 weeks and found that the most common reported side effect is gastrointestinal difficulty, including loss of appetite. The families reported an improvement in language and behavioral areas. Outcome measures in the design of future randomized clinical trials should include both behavioral and language measures. As with any other treatments, we emphasize that randomized clinical trials are needed to determine the efficacy of minocycline in fragile X syndrome.
authors.affiliation: M.I.N.D. Institute, University of California at Davis Medical Center, USA.
authors.forename: Agustini
authors.initials: A
authors.lastname: Utari
authors.forename: Weerasak
authors.initials: W
authors.lastname: Chonchaiya
authors.forename: Susan M
authors.initials: SM
authors.lastname: Rivera
authors.forename: Andrea
authors.initials: A
authors.lastname: Schneider
authors.forename: Randi J
authors.initials: RJ
authors.lastname: Hagerman
authors.forename: Sultana M H
authors.initials: SM
authors.lastname: Faradz
authors.forename: Iryna M
authors.initials: IM
authors.lastname: Ethell
authors.forename: Danh V
authors.initials: DV
authors.lastname: Nguyen
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000188:drug therapy; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007805:Language Development Disorders / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D018696:Neuroprotective Agents; D008911:Minocycline