title: [Evolution of antiretroviral treatment adherence from 2000 to 2008].
abstract: OBJECTIVE
  To evaluate antiretroviral treatment adherence in the HIV patient cohort of our hospital and observe their evolution over a 9-year period; also to determine the individual pattern of adherence over time.
  
  
  METHODS
  Descriptive study of the evolution of average annual adherence and the annual percentage of adherent patients greater than 95% from 2000 to 2008. We analysed the individual pattern of adherence over time and patients were classified into consistently adherent, consistently non-adherent, and fluctuating.
  
  
  RESULTS
  In the analysis of 577 patients, baseline adherence was significantly greater in naïve patients with respect to those who were pre-treated. Average annual adherence increased slightly and stayed at values around 95%. As with the percentage of patients with adherence greater than 95%, which increased from 64% in 2000 to 79% in 2008. In terms of the individual pattern of adherence over time, of the 468 patients analysed, the majority (59%) were consistently adherent, 4% non-adherent, and the rest (37%) fluctuated in their adherence.
  
  
  CONCLUSIONS
  In our cohort the overall adherence values maintained themselves over time and even show a positive trend, likely the result of systematic monitoring of adherence and implementation strategies to maintain adherence.
authors.affiliation: Servicio de Farmacia, Hospital de Galdakao-Usansolo, Bizkaia, Spain. mariaolatz.ibarrabarrueta@osakidetza.net
authors.forename: O
authors.initials: O
authors.lastname: Ibarra Barrueta
authors.forename: A
authors.initials: A
authors.lastname: Urrutia Losada
authors.forename: A
authors.initials: A
authors.lastname: López de Torre Querejazu
authors.forename: J
authors.initials: J
authors.lastname: Mayo Suárez
authors.forename: E
authors.initials: E
authors.lastname: Martinez Gutíerrez
authors.forename: M J
authors.initials: MJ
authors.lastname: Martínez-Bengoechea
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors; D016903:Drug Monitoring
chemical_list: D044966:Anti-Retroviral Agents