Brow motility in mitochondrial myopathy.
OBJECTIVE
To quantify the range of brow excursion in patients with mitochondrial myopathy and chronic progressive external ophthalmoplegia (CPEO).


METHODS
Comparative case series. Digital image processing techniques were used to quantify the upper eyelid resting position, brow excursion, and monocular eye movements (ductions) in 19 patients with mitochondrial myopathy and CPEO and in 27 healthy control subjects.


RESULTS
All patients with CPEO had ptosis ranging from 0.6 to 8 mm. For most patients, eye motility limitation was symmetrical. Elevation was the most affected eye movement. Patient's brow motility was on average 56.7% of the motility seen in the control group, and did not correlate with age or eye motility in any direction. Seventy-six percent of the brows displayed more than 2 mm of excursion.


CONCLUSIONS
In patients with CPEO, the occipitofrontalis muscle is less affected than the extraocular muscles. Most patients display a useful degree of brow excursion that theoretically can be used to clear the visual axis after a conservative brow suspension.
de Castro
Flávia Augusta Attié
FA
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Bandeirantes, Ribeirão Preto, SP, Brasil.
Cruz
Antonio Augusto V
AA
Sobreira
Cláudia Ferreira da Rosa
CF
D000293:Adolescent; D000328:Adult; D000368:Aged; D001763:Blepharoptosis / Q000503:physiopathology; D005133:Eye Movements / Q000502:physiology; D005138:Eyebrows / Q000503:physiopathology*; D005143:Eyelids / Q000502:physiology; D005152:Facial Muscles / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000503:physiopathology*; D017246:Ophthalmoplegia, Chronic Progressive External / Q000503:physiopathology*; D055815:Young Adult