title: Association to the Glypican-5 gene in multiple sclerosis.
abstract: Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.
authors.affiliation: Department of Neurology, Oslo University Hospital, Ullevål, University of Oslo, Oslo, Norway. aslaug.r.lorentzen@gmail.com
authors.forename: Aslaug R
authors.initials: AR
authors.lastname: Lorentzen
authors.forename: Espen
authors.initials: E
authors.lastname: Melum
authors.forename: Eva
authors.initials: E
authors.lastname: Ellinghaus
authors.forename: Cathrine
authors.initials: C
authors.lastname: Smestad
authors.forename: Inger-Lise
authors.initials: IL
authors.lastname: Mero
authors.forename: Jan H
authors.initials: JH
authors.lastname: Aarseth
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.forename: Elisabeth G
authors.initials: EG
authors.lastname: Celius
authors.forename: Benedicte A
authors.initials: BA
authors.lastname: Lie
authors.forename: Tom H
authors.initials: TH
authors.lastname: Karlsen
authors.forename: Andre
authors.initials: A
authors.lastname: Franke
authors.forename: Hanne F
authors.initials: HF
authors.lastname: Harbo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D053673:Glypicans / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D009664:Norway; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D053673:Glypicans