Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development.
As factors affecting neonatal neurodevelopment, methylmercury, polychlorinated biphenyls (PCBs), and maternal seafood intake reflecting n-3 polyunsaturated fatty acids (PUFAs) are believed to have adverse or beneficial effects, but there are a few reports addressing such factors simultaneously. We carried out a birth cohort study to clarify the effects of these three factors on the Neonatal Behavioral Assessment Scale (NBAS), administered 3 days after birth. In a total of 498 mother-neonate pairs, the total mercury level (median, 1.96microg/g) in maternal hair at parturition and the summation operatorPCB level (45.5ng/g-lipid) in cord blood were analyzed, and maternal seafood intake was estimated using a semi-quantitative food frequency questionnaire. A negative relationship between the hair mercury level and the motor cluster of NBAS was observed, even after adjusting for PCBs, maternal seafood intake, and possible confounders such as maternal age, birth weight, and parity. The summation operatorPCB level was negatively correlated with the motor cluster, but this association was attenuated after adjusting for mercury and the confounders. There was seen to be a positive association between maternal seafood intake and the motor cluster when considering the effects of mercury and PCBs. In conclusion, our data suggest that prenatal exposure to methylmercury adversely affects neonatal neurobehavioral function; in contrast, maternal seafood intake appears to be beneficial. The neurobehavioral effect of prenatal exposure to PCBs remains unclear in our study. Further research is necessary to elucidate interactive effects of methylmercury, PCBs, and n-3 PUFAs, originating from fish, on child neurodevelopment.
Suzuki
Keita
K
Environmental Health Sciences, Tohoku University, Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi 980-8576, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
Nakai
Kunihiko
K
Sugawara
Tomoko
T
Nakamura
Tomoyuki
T
Ohba
Takashi
T
Shimada
Miyuki
M
Hosokawa
Toru
T
Okamura
Kunihiro
K
Sakai
Takeo
T
Kurokawa
Naoyuki
N
Murata
Katsuyuki
K
Satoh
Chieko
C
Satoh
Hiroshi
H
D000328:Adult; D005260:Female; D006801:Humans; D018730:Infant Behavior; D007231:Infant, Newborn; D018811:Maternal Exposure; D008767:Methylmercury Compounds / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D017747:Seafood
D008767:Methylmercury Compounds; D011078:Polychlorinated Biphenyls