Signaling endosomes trigger synapse assembly.
In this issue of Neuron, Sharma et al. report that target-derived NGF exerts long-distance control of postsynaptic assembly. A major advance is the discovery that TrkA signaling endosomes are retrogradely transported to neuronal dendrites and directly trigger the clustering of postsynaptic density proteins.
Newbern
Jason M
JM
Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. jason_newbern@med.unc.edu
Li
Xiaoyan
X
Snider
William D
WD