title: Hypotriacylglycerolemic and antiobesity properties of a new fermented tea product obtained by tea-rolling processing of third-crop green tea (Camellia sinensis) leaves and loquat (Eriobotrya japonica) leaves.
abstract: We manufactured a new fermented tea by tea-rolling processing of third-crop green tea (Camellia sinensis) leaves and loquat (Eriobotrya japonica) leaves. The mixed fermented tea extract inhibited pancreatic lipase activity in vitro, and effectively suppressed postprandial hypertriacylglycerolemia in rats. Rats fed a diet containing 1% freeze-dried fermented tea extract for 4 weeks had a significantly lower liver triacylglycerol concentration and white adipose tissue weight than those fed the control diet lacking fermented tea extract. The activity of fatty acid synthase in hepatic cytosol markedly decreased in the fermented tea extract group as compared to the control group. The serum and liver triacylglycerol- and body fat-lowering effects of the mixed fermented tea extract were strong relative to the level of dietary supplementation. These results suggest that the new fermented tea product exhibited hypotriacylglycerolemic and antiobesity properties through suppression of both liver fatty acid synthesis and postprandial hypertriacylglycerolemia by inhibition of pancreatic lipase.
authors.affiliation: Graduate School of Human Health Science, University of Nagasaki, Nagayo-cho, Nishisonogi-gun, Nagasaki, Japan. katanaka@sun.ac.jp
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shizuka
authors.initials: S
authors.lastname: Tamaru
authors.forename: Shoko
authors.initials: S
authors.lastname: Nishizono
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyata
authors.forename: Kei
authors.initials: K
authors.lastname: Tamaya
authors.forename: Toshiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Echizen
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000494:pharmacology*; D028241:Camellia sinensis / Q000737:chemistry*; D019587:Dietary Supplements; D031983:Eriobotrya / Q000737:chemistry*; D005285:Fermentation; D005511:Food Handling; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D018515:Plant Leaves / Q000737:chemistry*; D019518:Postprandial Period / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood*
chemical_list: D019440:Anti-Obesity Agents; D000960:Hypolipidemic Agents; D013662:Tea; D014280:Triglycerides; D008049:Lipase