title: The use of platelet-rich plasma combined with demineralized freeze-dried bone allograft in the treatment of periodontal endosseous defects: a report of two clinical cases.
abstract: BACKGROUND
  On the basis of systematic reviews and randomized controlled trials, the authors provide reports of two cases in which platelet-rich plasma (PRP) combined with demineralized freeze-dried bone allograft (DFDBA) was used to treat periodontal endosseous defects.
  
  
  METHODS
  Clinicians treated two circumferential endosseous defects with a probing pocket depth of 5 and 8 millimeters, respectively (case 1), and a combined 1-2-3-wall endosseous defect with a probing pocket depth of 6 mm (case 2) by using the combination of PRP and DFDBA. At six months, complete periodontal pocket resolution occurred in all defects, and clinical attachment level and radiographic defect fill in all defects exhibited significant improvement compared with presurgical values.
  
  
  CONCLUSIONS
  The combination of PRP and DFDBA may be clinically and radiographically efficacious in the treatment of periodontal endosseous defects.
authors.affiliation: Periodontal Department, 401 Athens Military Hospital, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Markou
authors.forename: Eudoxie
authors.initials: E
authors.lastname: Pepelassi
authors.forename: Sotirios
authors.initials: S
authors.lastname: Kotsovilis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vrotsos
authors.forename: Helen
authors.initials: H
authors.lastname: Vavouraki
authors.forename: Harry Charalabos
authors.initials: HC
authors.lastname: Stamatakis
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D018775:Bone Demineralization Technique; D016025:Bone Transplantation / Q000379:methods*; D055113:Chronic Periodontitis / Q000601:surgery; D003646:Debridement; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D053657:Platelet-Rich Plasma; D016300:Radiography, Bitewing; D016745:Root Planing; D013524:Surgical Flaps; D014021:Tissue Preservation / Q000379:methods; D016896:Treatment Outcome