Crystallization after intravitreal ganciclovir injection.
OBJECTIVE
To report crystal formation as a complication of intravitreal ganciclovir injection.


METHODS
A 73-year-old female patient with unilateral cytomegalovirus retinitis was treated with intravitreous ganciclovir (4 mg/0.04 mL).


RESULTS
After the intravitreal injection, sudden crystallization was observed in the vitreous humor. The patient experienced marked reduction in visual acuity and increased intraocular pressure. Despite aqueous paracenthesis and pars plana vitrectomy, optic atrophy was observed and her visual acuity remained unimproved after 12 months.


CONCLUSIONS
Crystal formation can occur as a complication of intravitreal ganciclovir injection. Associated retinal and optic nerve damage was found which results in permanent visual morbidity.
Choopong
Pitipol
P
Department of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tesavibul
Nattaporn
N
Rodanant
Nattawut
N