title: Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.
abstract: hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Moorhouse
authors.forename: Christian
authors.initials: C
authors.lastname: Spiteri
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: Mire
authors.initials: M
authors.lastname: Zloh
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020134:Catalytic Domain / Q000187:drug effects; D057930:Click Chemistry; D018360:Crystallography, X-Ray; D006019:Glycolysis; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000080864:Lactate Dehydrogenase 5; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009243:NAD / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010072:Oxamic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000480:Alkynes; D007527:Isoenzymes; D008024:Ligands; D014230:Triazoles; D009243:NAD; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5; D010072:Oxamic Acid