title: Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates.
abstract: This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.
authors.affiliation: Laboratório de Biologia Molecular, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Ivy Bastos
authors.initials: IB
authors.lastname: Ramis
authors.forename: Tesiê Leopoldo
authors.initials: TL
authors.lastname: Fonseca
authors.forename: Ernani Pinho
authors.initials: EP
authors.lastname: de Moraes
authors.forename: Márcia Silveira
authors.initials: MS
authors.lastname: Fernandes
authors.forename: Raul
authors.initials: R
authors.lastname: Mendoza-Sassi
authors.forename: Obirajara
authors.initials: O
authors.lastname: Rodrigues
authors.forename: Carlos Renan Varela
authors.initials: CR
authors.lastname: Juliano
authors.forename: Carlos James
authors.initials: CJ
authors.lastname: Scaini
authors.forename: Pedro Eduardo Almeida
authors.initials: PE
authors.lastname: da Silva
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D016133:Polymerase Chain Reaction; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori; C063113:ice nucleation protein