title: Effect of a new moisturizing lotion on immediate and cumulative skin hydration: Two randomized, intra-individual, vehicle- and comparator-controlled studies.
abstract: Moisturizers increase skin hydration and can serve as adjunctive care in dermatologic conditions such as xerosis, psoriasis vulgaris, atopic dermatitis and ichthyosis, in which dry skin is implicated. A non-irritating hydrating lotion (CDA lotion) was recently developed. We assessed the effect of CDA lotion on skin hydration in two randomized, evaluator-blind and intra-individual comparison studies. After a single application, CDA lotion induced significantly greater hydration than the non-treated control for at least 24 hours (p < 0.001). After 4 days of twice-daily application, compared with the non-treated control, CDA lotion induced significantly greater skin hydration up to 3 days after treatment cessation (p < 0.05) and significant improvement in the clinical skin dryness score up to 7 days after treatment cessation (p < 0.05). The immediate and cumulative hydration effects of CDA lotion were also compared to those of several currently available moisturizing products. In summary, application of CDA lotion increases skin hydration and alleviates the condition of skin dryness.
authors.affiliation: Galderma R&D, Sãn Paolo, Brazil. alessandra.nogueira@galderma.com
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nogueira
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Sidou
authors.forename: Sylvie
authors.initials: S
authors.lastname: Brocard
mesh_terms: D000279:Administration, Cutaneous; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004643:Emollients / Q000494:pharmacology / Q000627:therapeutic use; D004817:Epidermis / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D003879:Dermatologic Agents; D004643:Emollients