title: [Cerebrospinal fluid-based diagnostics of CT-negative subarachnoid haemorrhage].
abstract: The diagnostic investigation of CT-negative subarachnoid haemorrhage (SAH) is a particular challenge in clinical neurology. Cerebrospinal fluid (CSF) analysis via lumbar puncture is the method of choice. The diagnosis of SAH in CSF is based on a bloody or xanthochromic discoloration of the CSF as well as on findings in non-automated CSF cytology including the detection of erythrophages and siderophages. The automated determination of CSF ferritin concentrations or spectrophotometric detection of xanthochromia may contribute to the diagnosis but are only useful with regard to the overall clinical picture. Generally, the knowledge of the time flow of CSF changes associated with SAH is essential for a correct interpretation of CSF findings.
authors.affiliation: Abteilung für Neurology, Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Deutschland. Hayrettin.tumani@uni-ulm.de
authors.forename: H
authors.initials: H
authors.lastname: Tumani
authors.forename: A
authors.initials: A
authors.lastname: Petzold
authors.forename: M
authors.initials: M
authors.lastname: Wick
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kühn
authors.forename: M
authors.initials: M
authors.lastname: Uhr
authors.forename: M
authors.initials: M
authors.lastname: Otto
authors.forename: A
authors.initials: A
authors.lastname: Regeniter
authors.forename: J
authors.initials: J
authors.lastname: Brettschneider
mesh_terms: D002555:Cerebrospinal Fluid / Q000166:cytology; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D003937:Diagnosis, Differential; D004906:Erythrocyte Count; D005293:Ferritins / Q000134:cerebrospinal fluid; D006485:Hemosiderin / Q000134:cerebrospinal fluid; D006801:Humans; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D008264:Macrophages / Q000166:cytology; D011237:Predictive Value of Tests; D012985:Software Design; D013053:Spectrophotometry; D013129:Spinal Puncture; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D005293:Ferritins; D006485:Hemosiderin