title: Effect of carnosine and its Trolox-modified derivatives on life span of Drosophila melanogaster.
abstract: This study investigated the effect of antioxidants, i.e., carnosine and its Trolox- (water-soluble analog of alpha-tocopherol) acylated derivatives (S,S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbonyl-beta-alanyl-L-histidine (S,S-Trolox-carnosine, STC) and (R,S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbonyl-beta-alanyl-L-histidine (R,S-Trolox-carnosine, RTC) on the life span of the fruit fly Drosophila melanogaster. Adding carnosine to foodstuff was accompanied and followed by a 20% increase in the average life span of males, but it did not influence the average life span of females. At the same time, adding STC to foodstuff prolonged average longevity both in males (by 16%) and females (by 36%), but the addition of RTC to foodstuff had no influence upon the average life span of insects of either gender. The compounds studied have previously been shown to protect neurons of the rat brain from oxidative stress in the descending order of efficiency: RTC > STC > carnosine. The finding obtained in the present study suggests another order of efficacy regarding the effect on life span in male insects: STC > carnosine > RTC (inefficient). No correlation between antioxidant protection of rat neurons and the effect on life span of the fruit fly makes it possible to suppose the presence of additional cellular targets to be acted upon by exposure of D. melanogaster to these compounds.
authors.affiliation: Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. slstvolinsky@mail.ru
authors.forename: Sergey
authors.initials: S
authors.lastname: Stvolinsky
authors.forename: Maxim
authors.initials: M
authors.lastname: Antipin
authors.forename: Kanji
authors.initials: K
authors.lastname: Meguro
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Abe
authors.forename: Alexander
authors.initials: A
authors.lastname: Boldyrev
mesh_terms: D000818:Animals; D002336:Carnosine / Q000737:chemistry / Q000494:pharmacology*; D002839:Chromans / Q000737:chemistry*; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male
chemical_list: D002839:Chromans; D002336:Carnosine; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid