Sarcoidosis in a patient with systemic sclerosis and primary biliary cirrhosis.
A 73-year-old woman who had been diagnosed with systemic sclerosis was admitted for further examination of bilateral hilar lymphadenopathy. Sarcoidosis was confirmed based on elevated serum levels of angiotensin-converting enzyme, a high proportion of lymphocytes and a high CD4/CD8 ratio in bronchoalveolar lavage fluid, abnormal (67)Gallium uptake in the mediastinum and noncaseating granulomas in skin biopsy specimens. In addition, high levels of antimitochondrial M2 antibodies and alkaline phosphatase indicated primary biliary cirrhosis (PBC). Here we describe a rare triplex of sarcoidosis, SSc and PBC. Although the etiology of this complex remains unknown, these three diseases might share some pathogenesis.
Sakamoto
Noriho
N
The Second Department of Internal Medicine, Nagasaki University School of Medicine. komiyakh1@yahoo.co.jp
Ishimatsu
Yuji
Y
Kakugawa
Tomoyuki
T
Hara
Atsuko
A
Hara
Shintaro
S
Amenomori
Misato
M
Fujita
Hanako
H
Mukae
Hiroshi
H
Kohno
Shigeru
S
D000368:Aged; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000175:diagnosis*; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis*; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis*