title: Measurement of treatment compliance using a medical device for glaucoma patients associated with intraocular pressure control: a survey.
abstract: OBJECTIVE
  To identify and characterize treatment compliance profiles of glaucoma patients and evaluate the association with intraocular pressure (IOP).
  
  
  METHODS
  A computerized device (Travalert((R))) that recorded daily instillation times and eye-drop counts was given for 3 months. Patients were declared compliant when at least 2 drops were instilled per day. Compliance rates were calculated for weekdays and weekends, separately, over 8 consecutive weeks. A principal components analysis (PCA) was followed by an ascendant hierarchical classification (AHC) to identify compliance groups.
  
  
  RESULTS
  140 patients were recruited (mean age 65.5 years; 51.8% female) of whom 83.6% had primary open-angle glaucoma with mean IOP 23.9 mmHg before Travalert((R)) use. 60.7% were treated with DuoTrav((R)) (travoprost timolol fixed combination) and 39.3% with travoprost. The PCA identified two axes (compliance and treatment weeks). The AHC identified 3 compliance groups: 'high' (56.6%, approx. 80% compliance), 'medium' (21.2%, approx. 50% compliance), and 'low' (22.1%, approx. 20% compliance). Demographics and glaucoma parameters did not predict low compliance. Final mean IOP was 16.1 mmHg, but higher in the low compliance group (17.7 mmHg, P = 0.02).
  
  
  CONCLUSIONS
  Compliance measurement by a medical device showed compliance rates <80% by 50% (approx.) of patients, significantly impacting IOP control. No demographic or glaucoma variable was associated with low compliance.
authors.affiliation: Hôpital des Quinzes-Vingt, Paris, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Nordmann
authors.forename: Christophe
authors.initials: C
authors.lastname: Baudouin
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Renard
authors.forename: Philippe
authors.initials: P
authors.lastname: Denis
authors.forename: Antoine
authors.initials: A
authors.lastname: Lafuma
authors.forename: Caroline
authors.initials: C
authors.lastname: Laurendeau
authors.forename: Viviane
authors.initials: V
authors.lastname: Jeanbat
authors.forename: Gilles
authors.initials: G
authors.lastname: Berdeaux