title: Development of a sustained fluoride delivery system.
abstract: OBJECTIVE
  To develop a novel delivery system by which fluoride incorporated into elastomeric rings, such as those used to ligate orthodontic wires, will be released in a controlled and constant manner.
  
  
  METHODS
  Polyethylene co-vinyl acetate (PEVA) was used as the model elastomer. Samples (N = 3) were prepared by incorporating 0.02 to 0.4 g of sodium fluoride (NaF) into previously prepared PEVA solution. Another group of samples prepared in the same manner were additionally dip-coated in PEVA to create an overcoat. Fluoride release studies were conducted in vitro using an ion selective electrode over a period of 45 days. The amount of fluoride released was compared to the optimal therapeutic dose of 0.7 microg F(-)/ring/d.
  
  
  RESULTS
  Only coated samples with the highest fluoride content (group D, 0.4 g of NaF) were able to release fluoride at therapeutic levels. When fluoride release from coated and uncoated samples with the same amount of NaF were compared, it was shown that the dip-coating technique resulted in a fluoride release in a controlled manner while eliminating the initial burst effect.
  
  
  CONCLUSIONS
  This novel fluoride delivery matrix provided fluoride release at a therapeutically effective rate and profile.
authors.affiliation: Naval Research Laboratories, Alexandria, VA, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Baturina
authors.forename: Eser
authors.initials: E
authors.lastname: Tufekci
authors.forename: Ozge
authors.initials: O
authors.lastname: Guney-Altay
authors.forename: Shadeed M
authors.initials: SM
authors.lastname: Khan
authors.forename: Gary E
authors.initials: GE
authors.lastname: Wnek
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Lindauer
mesh_terms: D002327:Cariostatic Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D003731:Dental Caries / Q000517:prevention & control; D016503:Drug Delivery Systems; D020724:Elastomers / Q000737:chemistry*; D005459:Fluorides / Q000032:analysis; D016382:Orthodontic Appliance Design; D009967:Orthodontic Appliances; D011095:Polyethylenes; D011145:Polyvinyls; D012969:Sodium Fluoride / Q000008:administration & dosage*
chemical_list: D002327:Cariostatic Agents; D020099:Coated Materials, Biocompatible; D020724:Elastomers; D011095:Polyethylenes; D011145:Polyvinyls; C477722:polyethylene-polyvinylacetate copolymer; D012969:Sodium Fluoride; D005459:Fluorides