Effect of uterine artery embolization on uterine and leiomyoma perfusion: evidence of transient myometrial ischemia on magnetic resonance imaging.
OBJECTIVE
To document immediate and short-term changes in uterine perfusion after uterine artery embolization (UAE).


METHODS
Fifteen patients (median age, 42 years) underwent UAE with tris-acryl gelatin microspheres and a limited embolization protocol. Contrast-enhanced magnetic resonance imaging was performed before therapy and 1 hour (immediate), 48-72 hours (subacute), and a median of 5 months (short-term follow-up) after UAE to determine uterine and leiomyoma perfusion. Leiomyomas with a minimum diameter of 10 mm were included. Changes in regional (ie, fundus/body/cervix), zonal (ie, endometrium/inner/middle and outer myometrial layer), and leiomyoma perfusion were documented.


RESULTS
UAE was technically successful in all patients. Immediate contrast-enhanced MR imaging revealed ischemia of the uterine body and fundus. The endometrium and inner myometrial layer was involved in all 15 patients; the middle layer was also involved in 13. Ischemic defects were seen in the outer layer in one patient but never in the cervix. Subacute follow-up showed reperfusion of the myometrium in 73% of patients. Ischemic defects occurred in the endometrial and junctional zone in four patients and in the middle zone in one. Five-month follow-up showed perfusion of all uterine layers in all patients. Ten patients had complete infarction of all leiomyomas; five presented with 11 partially perfused leiomyomas.


CONCLUSIONS
Limited bilateral UAE leads to transient uterine ischemia, particularly involving the endometrium and inner and middle zone of the myometrium of the uterine body and fundus. The cervix and subserosal layer are spared. Complete reperfusion of myometrial tissue is observed within 48-72 hours in most cases, whereas ischemic leiomyomas undergo irreversible infarction.
Scheurig-Muenkler
Christian
C
Department of Radiology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. christian.scheurig@charite.de
Wagner
Moritz
M
Franiel
Tobias
T
Hamm
Bernd
B
Kroencke
Thomas J
TJ
D000180:Acrylic Resins / Q000627:therapeutic use; D000328:Adult; D003287:Contrast Media; D005260:Female; D005780:Gelatin / Q000627:therapeutic use; D005858:Germany; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D007889:Leiomyoma / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009215:Myometrium / Q000098:blood supply*; D055420:Perfusion Imaging / Q000379:methods*; D011446:Prospective Studies; D012039:Regional Blood Flow; D013997:Time Factors; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000009:adverse effects; D014594:Uterine Neoplasms / Q000098:blood supply / Q000473:pathology / Q000628:therapy*
D000180:Acrylic Resins; D003287:Contrast Media; C496735:trisacryl gelatin microspheres; D005780:Gelatin