title: Volumetric analysis of coronary plaque characterization in patients with metabolic syndrome using 64-slice multi-detector computed tomography.
abstract: BACKGROUND
  Metabolic syndrome (MetS) is associated with adverse cardiovascular events and mortality, where acute coronary syndrome significantly impacts on mortality and morbidity. In contrast, evidences have accumulated that the lipid-rich plaque might play a critical role in acute coronary syndrome.
  
  
  RESULTS
  The study population consisted of 94 patients with suspected angina pectoris who underwent multi-detector computed tomography (MDCT). Of those, we identified 41 with MetS. In MDCT analysis, low-density plaque volume (LDPV) (42 ± 28 vs 24 ± 18 mm(3), P=0.0003), moderate-density plaque volume (105 ± 41 vs 82 ± 33 mm(3), P=0.003), total plaque volume (164 ± 70 vs 118 ± 59 mm(3), P=0.0008) and %LDPV (24.2 ± 10.0 vs 18.3 ± 7.1%, P=0.01) were significantly increased in the MetS group compared to the non-MetS group. Multivariate linear regression analysis after adjusting for confounding variables revealed that MetS was significantly correlated with an increase in %LDPV (β=0.48, P=0.0001). Multivariate logistic regression analysis for lipid-rich plaque after adjusting for confounding variables indicated that MetS was significantly associated with lipid-rich plaque (odds ratio: 5.99, 95% confidence intervals: 1.94-18.6, P=0.002).
  
  
  CONCLUSIONS
  Patients with MetS were strongly related to having a lipid-rich composition in their coronary plaque, as detected by MDCT.
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Arai
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Amano
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Uetani
authors.forename: Michio
authors.initials: M
authors.lastname: Nanki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Marui
authors.forename: Masataka
authors.initials: M
authors.lastname: Kato
authors.forename: Kiminobu
authors.initials: K
authors.lastname: Yokoi
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Ando
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kumagai
authors.forename: Ken
authors.initials: K
authors.lastname: Harada
authors.forename: Daiji
authors.initials: D
authors.lastname: Yoshikawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Ohshima
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Matsubara
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D000368:Aged; D000787:Angina Pectoris; D044466:Asian People; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000737:chemistry / Q000000981:diagnostic imaging*; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D008055:Lipids