Delayed akinetic catatonic mutism following methadone overdose.
A 49-year-old woman developed a catatonic mute state a few weeks after methadone overdose. Clinical, radiological and histological findings were consistent with toxic spongiform leukoencephalopathy, which adds a potentially deadly side-effect to a generally considered safe substitution for heroin.
Gheuens
Sarah
S
Department of Neurology, UZ Brussel, Laarbeeklaan 101, Jette, Belgium. sgheuens@bidmc.harvard.edu
Michotte
Alex
A
Flamez
Anja
A
De Keyser
Jacques
J
D000405:Akinetic Mutism / Q000139:chemically induced* / Q000175:diagnosis*; D002389:Catatonia / Q000139:chemically induced* / Q000175:diagnosis*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced / Q000175:diagnosis; D008691:Methadone / Q000506:poisoning*; D013997:Time Factors
D008691:Methadone