title: Shortening the duration of [18F]FDG PET brain examination for diagnosis of brain glioma.
abstract: OBJECTIVE
  Some patients cannot remain immobile for a long duration of 60 min, which is generally applied in the case of a 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) dynamic positron emission tomography (PET) scan. We investigated the change of the parametric values when the time duration of PET data was shortened.
  
  
  METHODS
  Eight normal subjects and four subjects with brain glioma were studied. The rate values of K(1), k(2), k(3), and K(i) parametric images were computed by changing the time duration from 20 to 60 min, and changes of those parametric values were compared.
  
  
  RESULTS
  The change was 20-30% and 3-5% for k(3) and K(i), respectively, when the scan time was shortened from 60 to 40 min. The ratios of normal and disease regions in k(3) and K(i) values were similar, and contrasts of those images were not changed when the scan time was shortened to 40 min.
  
  
  CONCLUSIONS
  These results demonstrate that the short time duration of [(18)F]FDG PET examination can provide an acceptable estimation of parametric k(3) and K(i) images.
authors.affiliation: Department of Clinical Radiology, Kagawa University Hospital, Miki-cho, Kita-gun, Kagawa, Japan. monden@med.kagawa-u.ac.jp
authors.forename: Toshihide
authors.initials: T
authors.lastname: Monden
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kudomi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sasakawa
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishiyama
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D013997:Time Factors
chemical_list: D019788:Fluorodeoxyglucose F18