Organizing pneumonia with a positive result for anti-CCP antibodies as the first clinical presentation of rheumatoid arthritis.
We report an 86-year-old woman who presented with organizing pneumonia (OP) with a positive anti-cyclic citrullinated peptide (anti-CCP) antibodies as the first manifestation of rheumatoid arthritis (RA). She experienced dyspnea, chest X-ray showed diffuse alveolar exudates indicated OP histologically. Although she did not present with articular symptoms initially, anti-CCP antibodies measured for differentiation of RA were positive. Eight months later, she showed representative manifestations of RA. Even though OP following joint involvement is frequent in RA, in rare cases it could be the first manifestation. This is the first case showing OP with a positive result for anti-CCP antibodies as the first manifestation of RA.
Komiya
Kosaku
K
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital. komiyakh1@yahoo.co.jp
Teramoto
Shinji
S
Kurosaki
Yuichiro
Y
Kashizaki
Fumihiro
F
Kawashima
Masahiro
M
Masuda
Kimihiko
K
Akagawa
Shinobu
S
Hebisawa
Akira
A
Ishii
Hiroshi
H
Kadota
Jun-ichi
J
D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010456:Peptides, Cyclic / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide