title: Combinatorial chemistry and the synthesis of compound libraries.
abstract: Solid Phase Organic Synthesis (SPOS) has become a powerful tool for the preparation of compound libraries used for screening efforts in Chemical Biology. While different types of screening libraries have become commercially available through several vendors, the elaboration of a hit compound in a screening campaign to a useful chemical probe still requires the preparation of a focused library. In this report, protocols are given which allow the synthesis of a focused compound library on solid phase by the diversification of a central scaffold using reliable functionalization reactions. Diversity elements can be introduced by attaching building blocks via amidation, esterification, reductive amination, and Suzuki cross-coupling.
authors.affiliation: Institute of Organic Chemistry, Graz University of Technology, Graz, Austria.
authors.forename: Rolf
authors.initials: R
authors.lastname: Breinbauer
authors.forename: Matthias
authors.initials: M
authors.lastname: Mentel
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000586:Amination; D000588:Amines / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004583:Electrons; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000438:Alcohols; D000588:Amines; D001897:Boronic Acids; D002264:Carboxylic Acids; D054852:Small Molecule Libraries