title: Safety studies of a recently developed microbicidal contraceptive gel (UniPron) in female baboons (Papio anubis).
abstract: To identify any toxicity on the vaginal epithelium, liver and kidney following UIniPron administration, ten healthy female olive baboons (Papio anubis) of reproductive age and of proven fertility were used. Five baboons were each treated with 15 g of UniPron intravaginally twice a week for 20-weeks and venous blood collected before and after each treatment. Venous blood was collected from five control animals as in the experimental females, but these control animals were not given any treatment. The endpoints that were evaluated included clinical chemistry profiles on kidney and liver functions and vaginal histopathology. Female baboons treated with 15 g of UniPron intravaginally showed no detectable adverse effects on clinical chemistry profiles investigated and vaginal histopathology. Repeated intravaginal exposure of female baboons to UniPron did not induce detectable vaginal irritation and there were no detectable histological changes. We conclude that administration of UniPron into baboon vagina did not cause any detectable toxicity.
authors.affiliation: Department of Reproductive Health/Biology, Institute of Primate Research, Karen, Nairobi, Kenya.
authors.forename: N
authors.initials: N
authors.lastname: Mburu
authors.forename: J A
authors.initials: JA
authors.lastname: Obiero
authors.forename: K
authors.initials: K
authors.lastname: Waititu
authors.forename: B N
authors.initials: BN
authors.lastname: Mwaura
authors.forename: J O
authors.initials: JO
authors.lastname: Orawo
authors.forename: I O
authors.initials: IO
authors.lastname: Farah
authors.forename: P G
authors.initials: PG
authors.lastname: Mwethera
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D007677:Kidney Function Tests; D008111:Liver Function Tests; D048530:Papio anubis; D013089:Spermatocidal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D014621:Vagina / Q000187:drug effects / Q000473:pathology; D014622:Vaginal Creams, Foams, and Jellies
chemical_list: D000890:Anti-Infective Agents; D013089:Spermatocidal Agents; D014622:Vaginal Creams, Foams, and Jellies