Age-related changes in the localization of DNA methyltransferases during meiotic maturation in mouse oocytes.
The effects of maternal aging on the localization of DNA methyltransferases were evaluated during mouse oocyte maturation using fluorescence staining. And we conclude that maternal aging affects the cytoplasmic-to-nuclear trafficking of DNA methyltransferases in mouse oocytes during the time from germinal vesicle breakdown to metaphase I.
Zhang
Lu
L
Department of Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Lu
Dan-Yu
DY
Ma
Wan-Yun
WY
Li
Ying
Y
D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D009865:Oocytes / Q000737:chemistry / Q000201:enzymology* / Q000254:growth & development*; D009866:Oogenesis / Q000502:physiology*
D004248:DNA (Cytosine-5-)-Methyltransferases