A principal case of multiple lymphoid collision tumors involving both B-cell chronic lymphocytic leukemia and metastatic malignant melanoma.
B-cell chronic lymphocytic leukemia/small lymphocytic B-cell lymphoma (CLL/B-SLL) is a neoplasm of B-cell lymphocytes that occurs frequently in the older population as an asymptomatic elevation of the white blood cell count (WBC) and has a good overall prognosis. Malignant melanoma of the skin is a neoplasm derived from cutaneous melanocytes that frequently arises among the elderly and, depending on certain histopathologic features, may metastasize loco-regionally or distally. However, only one report describes synchronous presentation of these two malignancies within the same lymph node. In this report, we present the unique case of an 87-year-old male with a presumed history of indolent CLL/B-SLL, in which metastatic malignant melanoma and CLL/B-SLL both involved 112 of 145 dissected regional lymph nodes. Possible explanations regarding the mechanisms that can lead to this rare presentation of both CLL/B-SLL and melanoma in the same lymph nodes are discussed.
Cantor
Aaron S
AS
Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Moschos
Stergios
S
Jukic
Drazen M
DM
D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000032:analysis; D051925:CD79 Antigens / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D017455:Receptors, IgE / Q000032:analysis; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
D018951:Antigens, CD20; D051925:CD79 Antigens; D017455:Receptors, IgE