title: Pneumatosis cystoides intestinalis induced by the α-glucosidase inhibitor miglitol.
abstract: Pneumatosis cystoides intestinalis (PCI) is a rare condition in which pneumocysts develop in the submucosa or subserosa of the colon. We report herein a case of PCI induced by the alpha-glucosidase inhibitor (alphaGI) miglitol. There have been 9 recorded cases of PCI induced by other alphaGIs, but this is the first report of miglitol causing PCI. The PCI lesions in our case were smaller than those induced by voglibose or acarbose. The possibility of PCI should be considered in diabetic patients on alphaGI therapy who complain of gastrointestinal symptoms, and the gastrointestinal tract should be thoroughly investigated in these patients.
authors.affiliation: Department of Internal Medicine, Hattori Memorial Hospital, Nara.
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Kojima
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Tsujimoto
authors.forename: Hisao
authors.initials: H
authors.lastname: Fujii
authors.forename: Tomoko
authors.initials: T
authors.lastname: Morimoto
authors.forename: Seisaku
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Saki
authors.initials: S
authors.lastname: Kato
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yasuhara
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Aizawa
authors.forename: Mizuho
authors.initials: M
authors.lastname: Sawai
authors.forename: Shiro
authors.initials: S
authors.lastname: Makutani
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tadao
authors.initials: T
authors.lastname: Mochi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukui
mesh_terms: D017485:1-Deoxynojirimycin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D008297:Male; D008875:Middle Aged; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced* / Q000175:diagnosis* / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; C045621:miglitol; D017485:1-Deoxynojirimycin