title: [Pemetrexed combined DDP in the treatment of advanced non-small cell lung cancer: a case report and literature review].
abstract: OBJECTIVE
  The aim of this study is to integrate with literature review, and explore the value of treatment of advanced non-small cell lung cancer with second line.
  
  
  METHODS
  For the metastatic progressive non-small cell lung adenocarcinoma patient, the evaluation of efficacy for complete response (CR) with endostar combined GC, the sequential treatment with gefitinib, used pemetrexed combined DDP as the second line treatment, followed up and observed with the progression free survival (PFS) and survival time of patient.
  
  
  RESULTS
  Pemetrexed combined DDP in the treatment of 5 cycles, the evaluation of lung cancer efficacy for CR, bone metastasis was steady, PFS was 6.6 months, survival time is 22 months now, improved the quality of living life.
  
  
  CONCLUSIONS
  For advanced non-small cell lung adenocarcinoma recurrence and metastasis, after the treatment of first line and maintenance therapy, selecting adequately pemetrexed combined DDP, as the second line treatment, can prolong the lifetime and improve the quality of life.
authors.affiliation: Department of Medical Oncology, Xin Hua Hospital Affiliated to Dalian University, Dalian 116021, China. zhongliuke2@163.com
authors.forename: Changlin
authors.initials: C
authors.lastname: Zhao
authors.forename: Hongqin
authors.initials: H
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Dai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D000068437:Pemetrexed; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D002945:Cisplatin