title: Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome.
abstract: BACKGROUND
  Uncertainty exists whether hearts from infants who have died of sudden infant death syndrome (SIDS) are acceptable for transplantation because the mechanism of death in SIDS remains unclear. We analyzed post-transplant outcomes in infants who received a heart from a donor where SIDS was the primary cause of brain death.
  
  
  METHODS
  This retrospective multicenter cohort study used data from the Organ Procurement and Transplant Network (OPTN). All infants aged < 12 months undergoing heart transplant between 1994 and 2008 were included. A Cox proportional hazards model was used to determine whether donor SIDS was independently associated with post-transplant graft loss (death or retransplant).
  
  
  RESULTS
  During the study period, 66 of 1033 infants (6.4%) who underwent heart transplant received an allograft from a SIDS donor. These infants were similar to the remaining infants with respect to age, diagnosis, blood type, and invasive support. In multivariable analysis, graft loss was associated with congenital heart disease (hazard ratio [HR], 1.6; 95% confidence interval [CI], 1.2-2.1), ventilator (HR, 1.4; 95% CI, 1.1-1.9), and extracorporeal membrane oxygenation support (HR, 3.0; 95% CI, 2.2-4.3), but not donor SIDS (HR, 1.0; 95% CI, 0.6-1.5), suggesting graft survival in SIDS-donor heart recipients was similar to the remaining infants. Primary causes of post-transplant death in infants receiving SIDS-donor hearts and the remaining infants were similar.
  
  
  CONCLUSIONS
  Graft survival was similar in infants who received SIDS-donor hearts compared with those who received hearts from donors who died of other causes. There was no increase in incidence of non-rejection-related cardiac deaths after transplant in these children.
authors.affiliation: Departments of Cardiology, Children's Hospital Boston, 300 Longwood Ave., Boston, MA 02115, USA.
authors.forename: Jennifer N A
authors.initials: JN
authors.lastname: Silva
authors.forename: Charles E
authors.initials: CE
authors.lastname: Canter
authors.forename: Tajinder P
authors.initials: TP
authors.lastname: Singh
authors.forename: Kimberlee
authors.initials: K
authors.lastname: Gauvreau
authors.forename: Gary E
authors.initials: GE
authors.lastname: Piercey
authors.forename: Charles I
authors.initials: CI
authors.lastname: Berul
authors.forename: Leslie B
authors.initials: LB
authors.lastname: Smoot
authors.forename: Elizabeth D
authors.initials: ED
authors.lastname: Blume
authors.forename: Francis
authors.initials: F
authors.lastname: Fynn-Thompson
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Almond
mesh_terms: D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D016027:Heart Transplantation; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013398:Sudden Infant Death; D014019:Tissue Donors