Hypoxia-inducible factors: post-translational crosstalk of signaling pathways.
Hypoxia-inducible factor-1 (HIF-1) has a central role in the mammalian program by which cells respond to hypoxia in both physiological and pathological situations. HIF-1 transcriptional activity, protein stabilization, protein-protein interaction, and cellular localization are mainly modulated by Post-translational modifications such as hydroxylation, acetylation, phosphorylation, S-nitrosylation, and SUMOylation. Here, we summarize current knowledge about Post-translational HIF-1 regulation and give additional information about useful methods to determine some of these various modifications.
Dimova
Elitsa Y
EY
Department of Chemistry/Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany.
Kietzmann
Thomas
T
D000107:Acetylation; D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D006900:Hydroxylation; D051793:Hypoxia-Inducible Factor 1 / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D047468:Immunoprecipitation; D008969:Molecular Sequence Data; D010766:Phosphorylation; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism; D015398:Signal Transduction
D051793:Hypoxia-Inducible Factor 1; D011994:Recombinant Proteins