title: Structure of a fibronectin type III-like module from Clostridium thermocellum.
abstract: The 1.6 A resolution structure of a fibronectin type III-like module from Clostridium thermocellum (PDB code 3mpc) with two molecules in the asymmetric unit is reported. The crystals used for data collection belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=35.43, b=45.73, c=107.72 A, and the structure was refined to an R factor of 0.166. Structural comparisons found over 800 similar structures in the Protein Data Bank. The broad range of different proteins or protein domains with high structural similarity makes it especially demanding to classify these proteins. Previous studies of fibronectin type III-like modules have indicated that they might function as ligand-binding modules, as a compact form of peptide linkers or spacers between other domains, as cellulose-disrupting modules or as proteins that help large enzyme complexes remain soluble.
authors.affiliation: BioSciences Center, National Renewable Energy Laboratory, 1617 Cole Boulevard, Golden, Colorado 80401-3305, USA.
authors.forename: Markus
authors.initials: M
authors.lastname: Alahuhta
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Roman
authors.initials: R
authors.lastname: Brunecky
authors.forename: William S
authors.initials: WS
authors.lastname: Adney
authors.forename: Shi-You
authors.initials: SY
authors.lastname: Ding
authors.forename: Michael E
authors.initials: ME
authors.lastname: Himmel
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Lunin
mesh_terms: D048013:Acetivibrio thermocellus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005353:Fibronectins / Q000737:chemistry*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary
chemical_list: D005353:Fibronectins