Development of a sustained fluoride delivery system.
OBJECTIVE
To develop a novel delivery system by which fluoride incorporated into elastomeric rings, such as those used to ligate orthodontic wires, will be released in a controlled and constant manner.


METHODS
Polyethylene co-vinyl acetate (PEVA) was used as the model elastomer. Samples (N = 3) were prepared by incorporating 0.02 to 0.4 g of sodium fluoride (NaF) into previously prepared PEVA solution. Another group of samples prepared in the same manner were additionally dip-coated in PEVA to create an overcoat. Fluoride release studies were conducted in vitro using an ion selective electrode over a period of 45 days. The amount of fluoride released was compared to the optimal therapeutic dose of 0.7 microg F(-)/ring/d.


RESULTS
Only coated samples with the highest fluoride content (group D, 0.4 g of NaF) were able to release fluoride at therapeutic levels. When fluoride release from coated and uncoated samples with the same amount of NaF were compared, it was shown that the dip-coating technique resulted in a fluoride release in a controlled manner while eliminating the initial burst effect.


CONCLUSIONS
This novel fluoride delivery matrix provided fluoride release at a therapeutically effective rate and profile.
Baturina
Olga
O
Naval Research Laboratories, Alexandria, VA, USA.
Tufekci
Eser
E
Guney-Altay
Ozge
O
Khan
Shadeed M
SM
Wnek
Gary E
GE
Lindauer
Steven J
SJ
D002327:Cariostatic Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D003731:Dental Caries / Q000517:prevention & control; D016503:Drug Delivery Systems; D020724:Elastomers / Q000737:chemistry*; D005459:Fluorides / Q000032:analysis; D016382:Orthodontic Appliance Design; D009967:Orthodontic Appliances; D011095:Polyethylenes; D011145:Polyvinyls; D012969:Sodium Fluoride / Q000008:administration & dosage*
D002327:Cariostatic Agents; D020099:Coated Materials, Biocompatible; D020724:Elastomers; D011095:Polyethylenes; D011145:Polyvinyls; C477722:polyethylene-polyvinylacetate copolymer; D012969:Sodium Fluoride; D005459:Fluorides