title: Influence of visceral obesity on oncologic outcome in patients with renal cell carcinoma.
abstract: OBJECTIVE
  At present, computed tomography (CT) is used in almost all patients with renal tumors. We aimed to investigate the relationship between visceral adipose tissue (VAT), as assessed by CT, and various other factors in patients with renal cell carcinoma (RCC).
  
  
  METHODS
  We undertook an examination of VAT in 117 male patients undergoing nephrectomy or partial nephrectomy at Chiba University Hospital using software designed to detect VAT in the horizontal plane of the body cavity. Pathological stage, microvascular invasion, tumor grade, performance status, C-reactive protein, BMI, hypertension, hyperlipemia, hyperglycemia, history of smoking and cause-specific survival rate were examined in relation to VAT, and multivariate Cox regression analysis was used to determine significant predictors of cause-specific survival.
  
  
  RESULTS
  VAT in patients with stage I disease was significantly greater than that in patients with more advanced disease (p = 0.0219). VAT in patients with microvascular invasion was significantly smaller than in those without microvascular invasion (p = 0.0260). Patients with high VAT had significantly higher cumulative cause-specific survival when compared to patients with low VAT (p = 0.0257).
  
  
  CONCLUSIONS
  VAT was associated with better clinical features in patients with RCC. Further study is necessary in order to clarify the role of VAT in RCC.
authors.affiliation: Section for Developing Surgical Devices, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan. nayayukio @ faculty.chiba-u.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Naya
authors.forename: Satoki
authors.initials: S
authors.lastname: Zenbutsu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Araki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Syuichi
authors.initials: S
authors.lastname: Kamijima
authors.forename: Takashi
authors.initials: T
authors.lastname: Imamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Nihei
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Igarashi
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007564:Japan; D007680:Kidney Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009392:Nephrectomy; D009765:Obesity / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome