Atypical fibroxanthoma with keloidal collagen.
Atypical fibroxanthoma (AFX) is a lesion that typically occurs on actinically damaged skin of the head and neck. Histopathology of these neoplasms reveals atypical cells, which often demonstrate positive staining for immunohistochemical markers such as vimentin and CD10. In the case reported, keloidal collagen was discovered on histopathology. To our knowledge, only rare reports in the literature describe an AFX with similar histopathologic findings, suggesting that this is a distinctive presentation of AFX.
Fussell
Jacqueline N
JN
Medical College of Georgia, Augusta, 30904, USA. jfussell@students.mcg.edu
Cooke
Elizabeth R
ER
Florentino
Frances
F
Sheehan
Daniel J
DJ
D014408:Biomarkers, Tumor / Q000032:analysis; D024042:Collagen Type I / Q000096:biosynthesis*; D003920:Diabetes Mellitus; D004423:Ear / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000150:complications; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000096:biosynthesis; D011347:Procollagen / Q000096:biosynthesis*; D006435:Renal Dialysis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D011347:Procollagen; D015260:Neprilysin