title: One-antigen mismatched related versus HLA-matched unrelated donor hematopoietic stem cell transplantation in adults with acute leukemia: Center for International Blood and Marrow Transplant Research results in the era of molecular HLA typing.
abstract: Approximately 13% of patients lacking an HLA-identical sibling have a one-antigen-mismatched related donor (MMRD). Historically, outcomes from the use of a one-antigen MMRD were considered equivalent to those from the use of a matched unrelated donor (UD). Recent improvements in UD stem cell transplantation (SCT) resulting from better molecular HLA matching justifies investigating whether UD should be preferred over MMRD in adult patients with acute leukemia. Here, we compared the outcomes of MMRD (n = 89) and HLA-A, -B, -C, and -DRB1 allele-matched UD (n = 700) SCT reported to the Center for International Blood and Marrow Transplant Research between 1995 and 2005. The patients underwent transplantation for acute myelogenous leukemia or acute lymphoblastic leukemia in first or second complete remission. Donor type was not associated with hematologic recovery. Univariate and multivariate comparisons of MMRD versus HLA-matched UD transplants showed no statistically significant differences in overall survival, disease-free survival, treatment-related mortality, relapse, or 100-day grade III-IV acute graft-versus-host disease (GVHD). MMRD SCT was associated with a lower rate of chronic GVHD at 1 year (35% vs 47%; P = .03), which was confirmed by multivariate analysis (relative risk, 0.58; 95% confidence interval, 0.39-0.85; P < .01). According to our data, HLA-matched UD and MMRD SCT are associated with comparable survival. Given that less chronic GVHD was observed in the MMRD transplantations, this option, when available, remains the first choice in patients with acute leukemia without an HLA-identical sibling in need of allogeneic SCT.
authors.affiliation: Hematology and Stem Cell Transplantation Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. dvalcarcel@santpau.cat
authors.forename: David
authors.initials: D
authors.lastname: Valcárcel
authors.forename: Jorge
authors.initials: J
authors.lastname: Sierra
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Fangyu
authors.initials: F
authors.lastname: Kan
authors.forename: Vikas
authors.initials: V
authors.lastname: Gupta
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Hale
authors.forename: David I
authors.initials: DI
authors.lastname: Marks
authors.forename: Philip L
authors.initials: PL
authors.lastname: McCarthy
authors.forename: Machteld
authors.initials: M
authors.lastname: Oudshoorn
authors.forename: Effie W
authors.initials: EW
authors.lastname: Petersdorf
authors.forename: Olle
authors.initials: O
authors.lastname: Ringdén
authors.forename: Michelle
authors.initials: M
authors.lastname: Setterholm
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Spellman
authors.forename: Edmund K
authors.initials: EK
authors.lastname: Waller
authors.forename: James L
authors.initials: JL
authors.lastname: Gajewski
authors.forename: Susana R
authors.initials: SR
authors.lastname: Marino
authors.forename: David
authors.initials: D
authors.lastname: Senitzer
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control; D015234:HLA-A Antigens / Q000032:analysis*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D035781:Siblings; D014019:Tissue Donors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens