title: Serious fatal and nonfatal non-AIDS-defining illnesses in Europe.
abstract: BACKGROUND
  Little is known about the incidence and risk factors for serious non-AIDS-defining events.
  
  
  METHODS
  The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS.
  
  
  RESULTS
  Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05).
  
  
  CONCLUSIONS
  Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.
authors.affiliation: Research Department of Infection and Population Health, University College Medical School, London, UK. a.mocroft@ucl.ac.uk
authors.forename: Amanda
authors.initials: A
authors.lastname: Mocroft
authors.forename: Peter
authors.initials: P
authors.lastname: Reiss
authors.forename: Jacek
authors.initials: J
authors.lastname: Gasiorowski
authors.forename: Bruno
authors.initials: B
authors.lastname: Ledergerber
authors.forename: Justyna
authors.initials: J
authors.lastname: Kowalska
authors.forename: Antonio
authors.initials: A
authors.lastname: Chiesi
authors.forename: Jose
authors.initials: J
authors.lastname: Gatell
authors.forename: Aza
authors.initials: A
authors.lastname: Rakhmanova
authors.forename: Margaret
authors.initials: M
authors.lastname: Johnson
authors.forename: Ole
authors.initials: O
authors.lastname: Kirk
authors.forename: Jens
authors.initials: J
authors.lastname: Lundgren
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality; D000367:Age Factors; D023241:Antiretroviral Therapy, Highly Active / Q000401:mortality; D018791:CD4 Lymphocyte Count; D004813:Epidemiology / Q000706:statistics & numerical data; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D009026:Mortality; D016012:Poisson Distribution; D016016:Proportional Hazards Models; D012307:Risk Factors