title: Anxiolytic-like effect of the monoterpene 1,4-cineole in mice.
abstract: Recent studies have shown that some monoterpenes exert anxiolytic- and depressant-like actions, however, these effects from monoterpene 1,4-cineole are still unknown. This work aimed to study the effects of 1,4-cineole in classic animal models for depression- and anxiety-like behavior, specifically the elevated plus maze (EPM), hole board, open field, pentobarbital sleeping time, forced swimming, tail suspension and rota rod tests. 1,4-Cineole was administered orally to mice (100, 200 and 400 mg/kg), while diazepam (1 or 2 mg/kg) and imipramine (10 or 30 mg/kg) were used as standard drugs. 1,4-Cineole (400 mg/kg) modified all parameters observed in the EPM, while no significant variation was observed on general motor activity in the open-field test. In the hole-board assay, 1,4-cineole induced increase on the number of head dips. Forced swimming and tail suspension tests showed that cineole (200 and/or 400 mg/kg) was able to promote significant increase on the immobility time, while a decreased sleep latency was observed (200 and 400 mg/kg ) on the pentobarbital sleeping time. Cineole had no effect on the motor coordination of animals in the rota rod test. The results suggest that 1,4-cineole presents potential anxiolytic-like action consistent with possible general depression of the CNS.
authors.affiliation: Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, 60430-270 Fortaleza, Ceará, Brazil.
authors.forename: Patrícia Bezerra
authors.initials: PB
authors.lastname: Gomes
authors.forename: Mariana Lima
authors.initials: ML
authors.lastname: Feitosa
authors.forename: Maria Izabel Gomes
authors.initials: MI
authors.lastname: Silva
authors.forename: Emmanuelle Coelho
authors.initials: EC
authors.lastname: Noronha
authors.forename: Brinell Arcanjo
authors.initials: BA
authors.lastname: Moura
authors.forename: Edith Teles
authors.initials: ET
authors.lastname: Venâncio
authors.forename: Emiliano Ricardo Vasconcelos
authors.initials: ER
authors.lastname: Rios
authors.forename: Damião Pergentino
authors.initials: DP
authors.lastname: de Sousa
authors.forename: Silvânia Maria Mendes
authors.initials: SM
authors.lastname: de Vasconcelos
authors.forename: Marta Maria de França
authors.initials: MM
authors.lastname: Fonteles
authors.forename: Francisca Cléa Florenço
authors.initials: FC
authors.lastname: de Sousa
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D000081005:Cyclohexane Monoterpenes; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; C058951:1,4-cineole