[Protective and therapeutic effects of schisandrol A on Abeta damaged PC12 cells].
OBJECTIVE
To observe the protective and therapeutic effect of schisandrol A on the Abeta damaged PC12 cells.


METHODS
PC12 cells were damaged by Abeta in vitro. Morphological changes were observed and the number of cells with neurite was analyzed by phase contrast microscope. The cell viability of PC12 cells was determined by the MTT method.


RESULTS
Many dispirited cells with atrophied or fragmented neurites in the Abeta damaged PC12 cells were observed under the microscope. More vital cells with longer neurites were observed in the schisandrol A treated PC12 cells and the number of cells with neurite increased. The difference of cell viability between the two groups was statistical significant.


CONCLUSIONS
Schisandrol A can antagonize the neurotoxicity of Abeta and has protective and therapeutic efficacy on Abeta damaged PC12 cells.
Xiao
Fei
F
Jinan University, School of Medicine, Guangzhou 510632, China.
Weng
Wen
W
Luo
Huan-Min
HM
D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D034242:Cyclooctanes / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats; D032141:Schisandra / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D034242:Cyclooctanes; D017705:Lignans; D018696:Neuroprotective Agents; C520474:schisandrol A