title: Signaling endosomes trigger synapse assembly.
abstract: In this issue of Neuron, Sharma et al. report that target-derived NGF exerts long-distance control of postsynaptic assembly. A major advance is the discovery that TrkA signaling endosomes are retrogradely transported to neuronal dendrites and directly trigger the clustering of postsynaptic density proteins.
authors.affiliation: Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. jason_newbern@med.unc.edu
authors.forename: Jason M
authors.initials: JM
authors.lastname: Newbern
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.forename: William D
authors.initials: WD
authors.lastname: Snider