Vertebrate Hedgehog signaling: cilia rule.
The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction. See research article: http://www.biomedcentral.com/1741-7007/8/65.
Wilson
Christopher W
CW
Tumour Biology and Angiogenesis Department, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. christww@gene.com
Stainier
Didier Y R
DY
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000378:metabolism
D002352:Carrier Proteins; D053823:Hedgehog Proteins; D029961:Zebrafish Proteins