[Fetal hepatosplenomegaly in the third trimester: A sign of leukemia in fetuses with Down syndrome].
Risk for leukemic conditions increases in individuals with Down syndrome. We report a third trimester antenatal diagnosis of leukemia in a Down syndrome fetus. The third trimester ultrasound examination revealed a hepatosplenomegaly, which may suggest a myelopoiesis disorder. A review of the literature of eight cases described antenatally and 14 cases in the immediate neonatal period is presented.
Fouché
C
C
Pôle mère-enfant, service gynécologie-obstétrique, centre hospitalier régional d'Orléans, BP 2439, 45032 Orléans cedex 1, France. chloe.fouche@hotmail.fr
Ramos
A
A
Esperandieu
O
O
Briault
S
S
Martin
J-G
JG
Desroches
A
A
D000328:Adult; D000649:Amniocentesis; D004314:Down Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000196:embryology; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D005602:France; D005865:Gestational Age; D006529:Hepatomegaly / Q000150:complications / Q000000981:diagnostic imaging* / Q000196:embryology; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000175:diagnosis* / Q000196:embryology; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D013163:Splenomegaly / Q000150:complications / Q000000981:diagnostic imaging* / Q000196:embryology; D016216:Ultrasonography, Prenatal