title: Chronic cannabinoid administration to periadolescent rats modulates the metabolic response to acute cocaine in the adult brain.
abstract: OBJECTIVE
  To analyze brain metabolic response to acute cocaine in male and female Wistar rats with or without a history of cannabinoid exposure during periadolescence.
  
  
  METHODS
  The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were administered to male and female rats during periadolescence. When these animals reached adulthood, saline and cocaine-induced changes in 2-deoxy-2-[¹⁸F]fluoro-D-: glucose (FDG) uptake were studied by positron emission tomography.
  
  
  RESULTS
  The baseline (post-saline) metabolism in the septal nuclei was higher in CP-females than in VH-females, although septal metabolism was lower in CP-females after cocaine, reaching similar values to those of VH-females at baseline. Cocaine did not affect metabolism in VH-females. Periadolescent cannabinoid treatment did not influence baseline metabolism in males although cocaine reduced the FDG uptake in the dorsal striatum of males that received the VH but not CP.
  
  
  CONCLUSIONS
  These results suggest that cannabinoids during periadolescence modify baseline and cocaine-evoked brain metabolism in a sex-dependent manner. In the case of CP-females, the involvement of septal metabolic alterations in their susceptibility to the rewarding effects of cocaine should be further investigated.
authors.affiliation: Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain. ahigueras@bec.uned.es.|Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain. ahigueras@bec.uned.es.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Higuera-Matas
authors.affiliation: Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain.|CIBERSAM, Madrid, Spain.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Soto-Montenegro
authors.affiliation: Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain.|Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Gonzalo L
authors.initials: GL
authors.lastname: Montoya
authors.affiliation: CIBERSAM, Madrid, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: García-Vázquez
authors.affiliation: Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Pascau
authors.affiliation: Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Miguéns
authors.affiliation: Department of Pharmaceutical and Food Sciences, School of Pharmacy, CEU University, Madrid, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Del Olmo
authors.affiliation: Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Vaquero
authors.affiliation: Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Lecumberri
authors.affiliation: Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, Spain.|CIBERSAM, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.affiliation: Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal nº10, 28040, Madrid, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Ambrosio
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002186:Cannabinoids / Q000008:administration & dosage* / Q000494:pharmacology*; D003042:Cocaine / Q000008:administration & dosage* / Q000494:pharmacology*; D005260:Female; D008279:Magnetic Resonance Imaging; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012686:Septal Nuclei / Q000187:drug effects / Q000378:metabolism
chemical_list: D002186:Cannabinoids; D003042:Cocaine