Neurobiology of adolescent substance use disorders: implications for prevention and treatment.
Adolescence represents a unique period of development with neuronal maturation accompanied by increases in behavioral risk taking. Although risky behavior is a likely marker of normative adolescent development, there is an early emergence of substance use disorders in this population. Adolescence represents a distinct period of vulnerability to substance use initiation and transitions to substance abuse and dependence. Of recent interest is understanding the neurobiology of adolescent substance use disorders, with adult studies being limited in their applicability to this developmentally sensitive maturation period and providing restricted insight into potential treatment and intervention. First, the authors review the neurobiology of adolescent substance use disorders and, second, the authors consider the implications of these findings for prevention and treatment.
Rutherford
Helena J V
HJ
Yale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA. helena.rutherford@yale.edu
Mayes
Linda C
LC
Potenza
Marc N
MN
D000293:Adolescent; D001921:Brain / Q000503:physiopathology; D003337:Corpus Callosum / Q000503:physiopathology; D003657:Decision Making / Q000502:physiology; D056344:Executive Function / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D008570:Memory, Short-Term / Q000502:physiology; D000297:Psychology, Adolescent; D019966:Substance-Related Disorders / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy