Ghrelin in diabetes and metabolic syndrome.
Metabolic syndrome is a cluster of related risk factors for cardiovascular disease, type 2 diabetes and liver disease. Obesity, which has become a global public health problem, is one of the major risk factors for development of metabolic syndrome and type 2 diabetes. Obesity is a complex disease, caused by the interplay between environmental and genetic factors. Ghrelin is one of the circulating peptides, which stimulates appetite and regulates energy balance, and thus is one of the candidate genes for obesity and T2DM. During the last years both basic research and genetic association studies have revealed association between the ghrelin gene and obesity, metabolic syndrome or type 2 diabetes.
Pulkkinen
Leena
L
Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio Campus, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Campus P.O. Box 1627 FI-70211 Kuopio, Finland.
Ukkola
Olavi
O
Kolehmainen
Marjukka
M
Uusitupa
Matti
M