title: Intake of dietary fats and colorectal cancer risk: prospective findings from the UK Dietary Cohort Consortium.
abstract: BACKGROUND
  Epidemiologic evidence for an association between colorectal cancer (CRC) risk and total dietary fat, saturated fat (SF), monounsaturated fat (MUFA) and polyunsaturated fat (PUFA) is inconsistent. Previous studies have used food frequency questionnaires (FFQ) to assess diet, but data from food diaries may be less prone to severe measurement error than data from FFQ.
  
  
  METHODS
  We conducted a case-control study nested within seven prospective UK cohort studies, comprising 579 cases of incident CRC and 1996 matched controls. Standardized dietary data from 4- to 7-day food diaries and from FFQ were used to estimate odds ratios for CRC risk associated with intake of fat and subtypes of fat using conditional logistic regression. We also calculated multivariate measurement error corrected odds ratios for CRC using repeated food diary measurements.
  
  
  RESULTS
  We observed no associations between intakes of total dietary fat or types of fat and CRC risk, irrespective of whether dietary data were obtained using food diaries or FFQ.
  
  
  CONCLUSIONS
  Our results do not support the hypothesis that intakes of total dietary fat, SF, MUFA or PUFA are linked to risk of CRC.
authors.affiliation: Medical Research Council Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom. ccd@soci.au.dk
authors.forename: Christina C
authors.initials: CC
authors.lastname: Dahm
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Keogh
authors.forename: Marleen A H
authors.initials: MA
authors.lastname: Lentjes
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Spencer
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Key
authors.forename: Darren C
authors.initials: DC
authors.lastname: Greenwood
authors.forename: Janet E
authors.initials: JE
authors.lastname: Cade
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Burley
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Shipley
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Brunner
authors.forename: Alison M
authors.initials: AM
authors.lastname: Stephen
authors.forename: Gita
authors.initials: G
authors.lastname: Mishra
authors.forename: Diana
authors.initials: D
authors.lastname: Kuh
authors.forename: Ian S
authors.initials: IS
authors.lastname: Fentiman
authors.forename: Ian R
authors.initials: IR
authors.lastname: White
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.forename: Kay Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Rodwell Bingham
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D011446:Prospective Studies; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D004041:Dietary Fats