Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness.
A 6-year-old girl presented with proximal muscle weakness of lower limbs. She was receiving phenytoin for epilepsy for 2 years. Serum phenytoin level was within therapeutic range. Serum 25(OH) vitamin D was low (5 ng/mL) and serum parathyroid hormone level was high. After administration of oral vitamin D, muscle weakness improved and vitamin D level increased to 39.11 ng/mL. Proximal muscle weakness due to vitamin D deficiency following phenytoin intake is rare in children.
Faridi
M M A
MM
Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi 110 095, India. drmmafaridi@gmail.com
Aggarwal
Anju
A
D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005684:Gait / Q000187:drug effects; D006801:Humans; D006962:Hyperparathyroidism, Secondary; D018908:Muscle Weakness / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D010672:Phenytoin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D014807:Vitamin D / Q000008:administration & dosage / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000139:chemically induced / Q000503:physiopathology
D014807:Vitamin D; D010672:Phenytoin