title: Pathological findings in cornea tissue of patients with penetrating keratoplasty.
abstract: The aim of this clinical study was to examine corneas extracted from the patients during penetrating keratoplasty for the presence of immunoglobulins and inflammatory cells that can be warning for the graft failure. Individual clinical diagnoses were correlated to the presence of the inflammatory signs in corneal tissue. The signs of inflammation in corneal layers were detected especially in group of patients classified as viral keratitis but were also found in corneas of patients with degenerative diseases of the cornea. Depending on the number of keratoplasties no statistical difference in analysed parameters was found. Inflammatory process represented by slight positive presence cellular infiltration and/or immunoglobulins could be present in corneal tissue also in absence of acute manifestation. Histological and immunohistochemical evaluation of corneal tissue from patients undergoing penetrating keratoplasty could improve estimation of correct diagnosis. Subsequently prompt adequate therapy could improve worse prognosis of corneal graft with evident immune process.
authors.affiliation: Associated Tissue Bank of Faculty of Medicine, P. J. Safárik University and L. Pasteur Faculty Hospital, Trieda SNP 1, Kosice, Slovakia. helga.kostelna@upjs.sk
authors.forename: Helga
authors.initials: H
authors.lastname: Kostelná
authors.forename: Ján
authors.initials: J
authors.lastname: Rosocha
authors.forename: Edita
authors.initials: E
authors.lastname: Paulíková
authors.forename: Igor
authors.initials: I
authors.lastname: Kozák
authors.forename: Mária
authors.initials: M
authors.lastname: Antalová
authors.forename: Martin
authors.initials: M
authors.lastname: Mahel
authors.forename: Denisa
authors.initials: D
authors.lastname: Harvanová
authors.forename: Jozefína
authors.initials: J
authors.lastname: Petrovicová
authors.forename: Ladislav
authors.initials: L
authors.lastname: Bobák
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003315:Cornea / Q000276:immunology / Q000473:pathology / Q000601:surgery; D005260:Female; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D007634:Keratitis / Q000276:immunology / Q000473:pathology / Q000601:surgery; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007136:Immunoglobulins