title: Interaction of cadmium with actin microfilaments in vitro.
abstract: Cadmium, an environmental and occupational health hazard, can substitute for calcium in the activation of calmodulin in several in vitro assays. It was shown that Cd(2+) can substitute for Ca(2+) in the induction of actin-based gelation in cytoplasmic extracts from rat liver; gelation induced by either Ca(2+) or Cd(2+) is inhibited by trifluoperazine, a well known calmodulin inhibitor; and in MDCK cells there is a Cd(2+)-induced redistribution of actin filaments with the loss of stress fibres and the appearance of actin bundles at the periphery of these cells.
authors.affiliation: Lab. Biofarmacia y Toxicidad Celular, Departamento de Biología Celular, Facultad de Medicina, Universidad Autonoma de San Luis Postosí, Apartado Postal 142, San Luis Potosí, SLP Mexico.
authors.forename: F
authors.initials: F
authors.lastname: Díaz-Barriga
authors.forename: L
authors.initials: L
authors.lastname: Carrizales
authors.forename: L
authors.initials: L
authors.lastname: Yanez
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández
authors.forename: M C
authors.initials: MC
authors.lastname: Domínguez Robles
authors.forename: E
authors.initials: E
authors.lastname: Palmer
authors.forename: J L
authors.initials: JL
authors.lastname: Saborío