The role of kisspeptin signaling in reproduction.
Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.
d'Anglemont de Tassigny
Xavier
X
Department of Physiology, Development and Neuroscience, Reproductive Physiology Group, University of Cambridge, Cambridge, United Kingdom.
Colledge
William Henry
WH
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics / Q000502:physiology; D006801:Humans; D059648:Kisspeptins; D009474:Neurons / Q000502:physiology; D011506:Proteins / Q000235:genetics; D051381:Rats; D012098:Reproduction / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology*
C106628:KISS1 protein, human; C491406:Kiss1 protein, rat; D059648:Kisspeptins; D011506:Proteins; D025521:Tumor Suppressor Proteins; D007987:Gonadotropin-Releasing Hormone