title: Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers.
abstract: OBJECTIVE
  The most common risk factor for bisphosphonate-related osteonecrosis of the jaws (BRONJ) is dentoalveolar surgery. It has been suggested that reduced serum C-terminal telopeptide (CTX) can determine the degree of osteoclast suppression and may predict the development of BRONJ after dentoalveolar surgery. Although there are many radiographic appearances associated with BRONJ, there are little data that describes changes preceding dentoalveolar surgery. The objective of this retrospective study was: 1) to investigate if reduced serum CTX values (i.e., <150 pg/mL) were associated with BRONJ after dentoalveolar surgery; and 2) to determine if specific radiographic changes are associated with teeth that develop BRONJ after extraction.
  
  
  METHODS
  A retrospective review of radiographic and/or serum CTX data was performed for 68 patients with a history of bisphosphonate therapy who either underwent dental extraction or were diagnosed with BRONJ in the Department of Oral and Maxillofacial Surgery during the period 2007-2009. Postoperative healing was assessed for 26 patients with reduced serum CTX levels (<150 pg/mL) who either underwent dental extraction or treatment for BRONJ. Preoperative radiographs were evaluated for 55 patients who either healed normally or developed BRONJ after dental extraction.
  
  
  RESULTS
  All 26 patients (100%) who had serum CTX levels <150 pg/mL healed successfully after dentoalveolar surgery (20 patients) or after treatment for BRONJ (6 patients). Among the 55 patients who underwent radiographic evaluation, 24 patients (83%) with BRONJ exhibited periodontal ligament (PDL) widening associated with extracted teeth, whereas only 3 patients (11%) who healed normally demonstrated PDL widening.
  
  
  CONCLUSIONS
  These data suggest that radiographic PDL widening may be a more sensitive indicator than CTX testing in predicting risk of BRONJ. Current guidelines that recommend minimal surgical intervention may need to be revised to include alternative strategies for the elimination or management of this pathology.
authors.affiliation: Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, New York 10010, USA. kef3@nyu.edu
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Fleisher
authors.forename: Garrett
authors.initials: G
authors.lastname: Welch
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kottal
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Craig
authors.forename: Deepak
authors.initials: D
authors.lastname: Saxena
authors.forename: Robert S
authors.initials: RS
authors.lastname: Glickman
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging; D050071:Bone Density Conservation Agents / Q000009:adverse effects; D016022:Case-Control Studies; D015331:Cohort Studies; D024042:Collagen Type I / Q000097:blood*; D004164:Diphosphonates / Q000009:adverse effects; D006801:Humans; D007571:Jaw Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010020:Osteonecrosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010455:Peptides / Q000097:blood*; D010513:Periodontal Ligament / Q000000981:diagnostic imaging* / Q000473:pathology; D011237:Predictive Value of Tests; D011861:Radiography, Dental / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D014081:Tooth Extraction / Q000009:adverse effects
chemical_list: D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D004164:Diphosphonates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide