Our unindicted coconspirators: human metabolism from a microbial perspective.
The human gut is populated by a microbiota composed of tens of trillions of organisms and millions of genes that together form a metabolic "organ." Intra- and interpersonal differences in the structure and functions of this organ suggest that it could contribute to our normal metabolic variations and also to metabolic disorders. This Commentary discusses experimental approaches for connecting microbial and host metabolism in the context of health and disease.
Goodman
Andrew L
AL
Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis MO 63108, USA.
Gordon
Jeffrey I
JI
D000818:Animals; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis / Q000628:therapy; D054892:Metagenome; D051379:Mice