title: CFD modeling of an ultrasonic separator for the removal of lipid particles from pericardial suction blood.
abstract: A computational fluid dynamics (CFD) model is presented to simulate the removal of lipid particles from blood using a novel ultrasonic quarter-wavelength separator. The Lagrangian-Eulerian CFD model accounts for conservation of mass and momentum, for the presence of lipid particles of a range of diameters, for the acoustic force as experienced by the particles in the blood, as well as for gravity and other particle-fluid interaction forces. In the separator, the liquid flows radially inward within a fluid chamber formed between a disc-shaped transducer and a disc-shaped reflector. Following separation of the lipid particles, blood exits the separator axially through a central opening on the disc-shaped reflector. Separator diameters studied varied between 12 and 18 cm, and gap sizes between the discs of 600 μm, 800 μm and 1 mm were considered. Results show a strong effect of residence time of the particles within the chamber on the separation performance. Different separator configurations were identified, which could give a lipid removal performance of 95% or higher when processing 62.5 cm (3)/min of blood. The developed model provides a design method for the selection of geometric and operating parameters for the ultrasonic separator.
authors.affiliation: Department of Engineering Science, Institute ofBiomedical Engineering, University of Oxford, Oxford, UK. giuliana.trippa@eng.ox.ac.uk
authors.forename: Giuliana
authors.initials: G
authors.lastname: Trippa
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Ventikos
authors.forename: David P
authors.initials: DP
authors.lastname: Taggart
authors.forename: Constantin-C
authors.initials: CC
authors.lastname: Coussios
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D003198:Computer Simulation; D018056:Hemorheology / Q000502:physiology*; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000302:isolation & purification; D008955:Models, Cardiovascular; D010496:Pericardium; D014159:Transducers; D014465:Ultrasonics / Q000379:methods*
chemical_list: D008055:Lipids