title: Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon.
abstract: Severe rhabdomyolysis (creatine phosphokinase = 29,400 U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax. Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with P. vivax infection showed no comorbidities. The pathogenesis is still unclear. Although rhabdomyolysis is generally reported as a complication of Plasmodium falciparum malaria, leading to metabolic and renal complications,1 it has been reported in a patient with P. vivax infection with myoadenylate deaminase deficiency.2 We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed P. vivax infection.
authors.affiliation: Tropical Medicine Foundation of Amazonas, Manaus, Amazonas, Brazil. amsiqueira@gmail.com
authors.forename: André M
authors.initials: AM
authors.lastname: Siqueira
authors.forename: Márcia A A
authors.initials: MA
authors.lastname: Alexandre
authors.forename: Maria P G
authors.initials: MP
authors.lastname: Mourão
authors.forename: Valquir S
authors.initials: VS
authors.lastname: Santos
authors.forename: Suely K
authors.initials: SK
authors.lastname: Nagahashi-Marie
authors.forename: Maria G C
authors.initials: MG
authors.lastname: Alecrim
authors.forename: Marcus V G
authors.initials: MV
authors.lastname: Lacerda
mesh_terms: D000293:Adolescent; D000818:Animals; D001938:Brazil; D006801:Humans; D016780:Malaria, Vivax / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010966:Plasmodium vivax; D012206:Rhabdomyolysis / Q000150:complications / Q000469:parasitology*