title: Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
abstract: We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
authors.affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.|Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Thye
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Fredrik O
authors.initials: FO
authors.lastname: Vannberg
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Sunny H
authors.initials: SH
authors.lastname: Wong
authors.affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.|Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Ellis
authors.initials: E
authors.lastname: Owusu-Dabo
authors.affiliation: Health Research Unit, Ghana Health Service, Accra, Ghana.
authors.forename: Ivy
authors.initials: I
authors.lastname: Osei
authors.affiliation: Health Research Unit, Ghana Health Service, Accra, Ghana.
authors.forename: John
authors.initials: J
authors.lastname: Gyapong
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sirugo
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Fatou
authors.initials: F
authors.lastname: Sisay-Joof
authors.affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.|Komfo Anokye Teaching Hospital, Kumasi, Ghana.
authors.forename: Anthony
authors.initials: A
authors.lastname: Enimil
authors.affiliation: Health Research Unit, Ghana Health Service, Accra, Ghana.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Chinbuah
authors.affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Sian
authors.initials: S
authors.lastname: Floyd
authors.affiliation: Karonga Prevention Study, Chilumba, Karonga District, Malawi.
authors.forename: David K
authors.initials: DK
authors.lastname: Warndorff
authors.affiliation: Karonga Prevention Study, Chilumba, Karonga District, Malawi.
authors.forename: Lifted
authors.initials: L
authors.lastname: Sichali
authors.affiliation: Karonga Prevention Study, Chilumba, Karonga District, Malawi.
authors.forename: Simon
authors.initials: S
authors.lastname: Malema
authors.affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Amelia C
authors.initials: AC
authors.lastname: Crampin
authors.affiliation: Karonga Prevention Study, Chilumba, Karonga District, Malawi.
authors.forename: Bagrey
authors.initials: B
authors.lastname: Ngwira
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Yik Y
authors.initials: YY
authors.lastname: Teo
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Kerrin
authors.initials: K
authors.lastname: Small
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Kirk
authors.initials: K
authors.lastname: Rockett
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Dominic
authors.initials: D
authors.lastname: Kwiatkowski
authors.affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom.|Karonga Prevention Study, Chilumba, Karonga District, Malawi.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Fine
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Hill
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Melanie
authors.initials: M
authors.lastname: Newport
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Christian
authors.initials: C
authors.lastname: Lienhardt
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Adegbola
authors.affiliation: MRC Laboratories, Fajara, Banjul, The Gambia.
authors.forename: Tumani
authors.initials: T
authors.lastname: Corrah
authors.affiliation: Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Morris
authors.affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Meyer
authors.affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: Rolf D
authors.initials: RD
authors.lastname: Horstmann
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
authors.forename: Adrian V S
authors.initials: AVS
authors.lastname: Hill
mesh_terms: D016022:Case-Control Studies; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D005714:Gambia; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D005869:Ghana; D006801:Humans; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics*