title: The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress.
abstract: The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.
authors.affiliation: Department of Clinical Oncology, Leiden University Medical Center, K1-P, Albinusdreef 2, 2333 ZA Leiden, Netherlands. T.van_Hall@LUMC.nl
authors.forename: Thorbald
authors.initials: T
authors.lastname: van Hall
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Oliveira
authors.forename: Simone A
authors.initials: SA
authors.lastname: Joosten
authors.forename: Tom H M
authors.initials: TH
authors.lastname: Ottenhoff
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D006680:HLA Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice; D015398:Signal Transduction; D000097625:HLA-E Antigens
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens; C032907:Q surface antigens