Optic neuropathy following radiotherapy for Cushing's disease: case report and literature review.
Radiation-induced optic neuropathy is a rare adverse effect of radiotherapy applied for the treatment of pituitary adenomas. We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy. Sixteen months after radiotherapy, the patient was presented with declining visual acuity, and radiation-induced optic neuropathy was diagnosed. Despite treatment with glucocorticoids and hyperbaric oxygen, her vision did not improve. The pathophysiology, prevention and treatment of radiation-induced optic neuropathy, including the efficacy of hyperbaric oxygen therapy are reviewed.
Ballian
Nikiforos
N
Department of Surgery, University of Wisconsin, Madison, WI, USA.
Androulakis
Ioannis I
II
Chatzistefanou
Klio
K
Samara
Christianna
C
Tsiveriotis
Konstantinos
K
Kaltsas
Gregory A
GA
D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications / Q000532:radiotherapy*; D000236:Adenoma / Q000150:complications / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006931:Hyperbaric Oxygenation; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D047748:Pituitary ACTH Hypersecretion / Q000209:etiology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D017211:Treatment Failure; D014792:Visual Acuity / Q000528:radiation effects
D005938:Glucocorticoids