title: The trajectory of gait speed preceding mild cognitive impairment.
abstract: OBJECTIVE
  To compare the trajectory of motor decline, as measured by gait speed and finger-tapping speed, between elderly people who developed mild cognitive impairment (MCI) and those who remained cognitively intact. We also sought to determine the approximate time at which the decline in motor function accelerated in persons who developed MCI.
  
  
  METHODS
  Longitudinal cohort study.
  
  
  METHODS
  Participants were 204 healthy seniors (57.8% women) from the Oregon Brain Aging Study evaluated for up to 20 years using annual neurologic, neuropsychological, and motor examinations.
  
  
  METHODS
  The pattern of motor decline with aging was compared using a mixed-effects model with an interaction term for age and a clinical diagnosis of MCI. The time before diagnosis of MCI, when the change in gait or finger-tapping speed accelerates, was assessed using a mixed-effects model with a change point for men and women, separately and combined, who developed MCI.
  
  
  RESULTS
  The rates of change, with aging, in gait speed (P < .001) and finger-tapping speed in the dominant hand (P = .003) and nondominant hand (P < .001) were significantly different between participants who developed MCI (converters) and those who did not (nonconverters). Using a change point analysis for MCI converters, the decrease in gait speed accelerated by 0.023 m/s/y (P < .001), occurring 12.1 years before the onset of MCI. An acceleration in gait speed decline occurred earlier in men than women. For tapping speed, the change point occurred after the onset of MCI for both dominant and nondominant hands when men and women were combined.
  
  
  CONCLUSIONS
  Motor decline as indexed by gait speed accelerates up to 12 years before MCI. Longitudinal changes in motor function may be useful in the early detection of dementia during preclinical stages, when the utility of disease-modifying therapies would be greatest.
authors.affiliation: Layton Aging and Alzheimer's Disease Center, Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Mail Code CR-131, Portland, OR 97239, USA. buracchi@ohsu.edu
authors.forename: Teresa
authors.initials: T
authors.lastname: Buracchio
authors.forename: Hiroko H
authors.initials: HH
authors.lastname: Dodge
authors.forename: Diane
authors.initials: D
authors.lastname: Howieson
authors.forename: Dara
authors.initials: D
authors.lastname: Wasserman
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kaye
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000150:complications*; D015331:Cohort Studies; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology*; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D012737:Sex Factors