Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
Földy
Csaba
C
Department of Anatomy and Neurobiology, University of California, Irvine, California, USA. foldy@stanford.edu
Lee
Sang-Hun
SH
Morgan
Robert J
RJ
Soltesz
Ivan
I
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology; D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D006706:Homeostasis; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D042541:Intracellular Space / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000502:physiology*; D010320:Parvalbumins / Q000378:metabolism; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism; D013569:Synapses / Q000502:physiology*
D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels; D002712:Chlorides; D010320:Parvalbumins; D011963:Receptors, GABA-A; D002766:Cholecystokinin