title: The pioneer round of translation: features and functions.
abstract: In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
authors.affiliation: Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. lynne_maquat@urmc.rochester.edu
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Maquat
authors.forename: Woan-Yuh
authors.initials: WY
authors.lastname: Tarn
authors.forename: Olaf
authors.initials: O
authors.lastname: Isken
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D006801:Humans; D014176:Protein Biosynthesis; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins