title: Anti-Herpetic Activity of Callissia fragrans and Simmondsia chinensis Leaf Extracts In Vitro.
abstract: The antiviral activity of Callissia fragrans and Simnondsia chinensis aquatic and ethanol leaf extracts, as well as purified fractions from these extracts was studied against herpetic viruses in vitro. Ethanol extract of C. fragrans effectively inhibited the infection of Vero cells by HSV-1, HSV-2 in vitro, while its aquatic extract inhibited only VZV. Although S. chinensis leaf extract strongly inhibited all studied viruses, the selectivity index of this extract was very low, due to its high toxicity. However, the majority of its fractions showed low toxicity and higher antiviral activity and therefore very high SI. Strong interactions between virus and extracts were found.
authors.affiliation: Department of Virology and Developmenral Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Yarmolinsky
authors.forename: Michele
authors.initials: M
authors.lastname: Zaccai
authors.forename: Shimon
authors.initials: S
authors.lastname: Ben-Shabat
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Huleihel