Benzoyl peroxide (BPO)-promoted oxidative trifluoromethylation of tertiary amines with trimethyl(trifluoromethyl)silane.
The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines.
Chu
Lingling
L
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032, China.
Qing
Feng-Ling
FL
D000588:Amines / Q000737:chemistry*; D001585:Benzoyl Peroxide / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D000588:Amines; D006845:Hydrocarbons, Fluorinated; D012821:Silanes; D044005:Tetrahydroisoquinolines; C509472:trimethyl(trifluoromethyl)silane; D001585:Benzoyl Peroxide