title: Sensitivity of laser flare photometry compared to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis.
abstract: To study the sensitivity of laser flare photometry (LFP) in monitoring anterior chamber inflammation by correlating LFP measurements with slit-lamp evaluation of aqueous cells in HLA-B27-related uveitis in a prospective trial. Slit-lamp cell evaluation was correlated with LFP-measured flare in a masked fashion in HLA-B27-related uveitis patients receiving standard topical therapy. At the time of 50 and 90% LFP flare reduction, the corresponding reduction of cells was recorded and statistically compared using the sign test. Forty-three episodes (in 43 patients) of acute anterior HLA-B27-related uveitis were included. LFP flare reduction and slit-lamp cell reduction were strongly correlated. LFP was significantly more sensitive for both 50% (P = 0.001) and 90% (P = 0.02) LFP flare reduction in assessing the decrease of anterior chamber inflammation. LFP was superior to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis. Flare, becoming a quantitative parameter when measured by LFP, rather than cells, should be considered the gold standard to measure anterior chamber inflammation in uveitis.
authors.affiliation: Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialised Care (COS), Rue de la Grotte, 1003, Lausanne, Switzerland.
authors.forename: Ottavio
authors.initials: O
authors.lastname: Bernasconi
authors.forename: Marina
authors.initials: M
authors.lastname: Papadia
authors.forename: Carl P
authors.initials: CP
authors.lastname: Herbort
mesh_terms: D001082:Aqueous Humor; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D015796:HLA-B27 Antigen / Q000032:analysis; D007429:Intraocular Pressure; D007834:Lasers; D010783:Photometry; D012680:Sensitivity and Specificity; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D014792:Visual Acuity
chemical_list: D015796:HLA-B27 Antigen