title: Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes.
abstract: This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.
authors.affiliation: Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
authors.forename: C
authors.initials: C
authors.lastname: Kilewo
authors.forename: U C M
authors.initials: UC
authors.lastname: Natchu
authors.forename: A
authors.initials: A
authors.lastname: Young
authors.forename: D
authors.initials: D
authors.lastname: Donnell
authors.forename: E
authors.initials: E
authors.lastname: Brown
authors.forename: J S
authors.initials: JS
authors.lastname: Read
authors.forename: U
authors.initials: U
authors.lastname: Sharma
authors.forename: B H
authors.initials: BH
authors.lastname: Chi
authors.forename: R
authors.initials: R
authors.lastname: Goldenberg
authors.forename: I
authors.initials: I
authors.lastname: Hoffman
authors.forename: T E
authors.initials: TE
authors.lastname: Taha
authors.forename: W W
authors.initials: WW
authors.lastname: Fawzi
mesh_terms: D000328:Adult; D017954:Africa South of the Sahara; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011263:Pregnancy Trimester, Third; D015995:Prevalence