title: Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents.
abstract: A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: J Surendranadha
authors.initials: JS
authors.lastname: Reddy
authors.forename: M Janaki
authors.initials: MJ
authors.lastname: Ramaiah
authors.forename: E Vijaya
authors.initials: EV
authors.lastname: Bharathi
authors.forename: D
authors.initials: D
authors.lastname: Dastagiri
authors.forename: M Kashi
authors.initials: MK
authors.lastname: Reddy
authors.forename: S N C V L
authors.initials: SN
authors.lastname: Pushpavalli
authors.forename: Manika
authors.initials: M
authors.lastname: Pal-Bhadra
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D011743:Pyrimidines; D001569:Benzodiazepines; C030986:pyrimidine; C023650:aniline