title: International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.
abstract: OBJECTIVE
  To define consensus statement regarding allogeneic stem-cell transplantation (Allo-SCT) as a treatment option for multiple myeloma (MM) on behalf of International Myeloma Working Group.
  
  
  METHODS
  In this review, results from prospective and retrospective studies of Allo-SCT in MM are summarized.
  
  
  RESULTS
  Although the introduction of reduced-intensity conditioning (RIC) has lowered the high treatment-related mortality associated with myeloablative conditioning, convincing evidence is lacking that Allo-RIC improves the survival compared with autologous stem-cell transplantation.
  
  
  CONCLUSIONS
  New strategies are necessary to make Allo-SCT safer and more effective for patients with MM. Until this is achieved, Allo-RIC in myeloma should only be recommended in the context of clinical trials.
authors.affiliation: Department of Hematology, University Medical Center Utrecht, Utrecht, the Netherlands. h.lokhorst@umcutrecht.nl
authors.forename: Henk
authors.initials: H
authors.lastname: Lokhorst
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: David
authors.initials: D
authors.lastname: Vesole
authors.forename: Benedetto
authors.initials: B
authors.lastname: Bruno
authors.forename: Jesus
authors.initials: J
authors.lastname: San Miguel
authors.forename: Jose A
authors.initials: JA
authors.lastname: Pérez-Simon
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Kröger
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Gosta
authors.initials: G
authors.lastname: Gahrton
authors.forename: Cristina
authors.initials: C
authors.lastname: Gasparetto
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
authors.forename: William
authors.initials: W
authors.lastname: Bensinger
mesh_terms: D018572:Disease-Free Survival; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D009101:Multiple Myeloma / Q000601:surgery*; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous