title: An association study of 21 potential Alzheimer's disease risk genes in a Finnish population.
abstract: Alzheimer's disease (AD) is a genetically complex disorder encompassing several individual susceptibility genes with low risk effects. To assess the risk gene effects in a cohort consisting of ∼ 1300 Finnish AD patients and controls, 21 candidate gene polymorphisms were selected for genotyping on the basis of the meta-analyses retrieved from the AlzGene database. A significant genotype and allele association with AD was observed with rs1800629 in the tumor necrosis factor α (TNF). Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD.
authors.affiliation: Institute of Clinical Medicine-Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Sarajärvi
authors.forename: Seppo
authors.initials: S
authors.lastname: Helisalmi
authors.forename: Leila
authors.initials: L
authors.lastname: Antikainen
authors.forename: Petra
authors.initials: P
authors.lastname: Mäkinen
authors.forename: Anne Maria
authors.initials: AM
authors.lastname: Koivisto
authors.forename: Sanna-Kaisa
authors.initials: SK
authors.lastname: Herukka
authors.forename: Annakaisa
authors.initials: A
authors.lastname: Haapasalo
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.forename: Mikko
authors.initials: M
authors.lastname: Hiltunen
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016208:Databases, Factual; D005387:Finland; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha