Regulatory T cell content in the bone marrow graft does not predict the occurrence of acute GVHD.
The subpopulation of regulatory T cells (Treg) was shown to play a key role in alloreactive responses. In allogeneic hematopoietic stem cell transplantation, several groups tested whether Treg content in transplants correlates with graft-versus-host disease (GVHD) with controversial results. In a retrospective study of 49 consecutive HLA-matched sibling transplantations, we studied the relationship between Treg content in bone marrow transplants and acute GVHD (aGVHD) occurrence. We observed a large variability in Treg in bone marrow grafts. However, contrary to previous observations in peripheral blood stem cells transplantation, we report that the Treg content of allogeneic bone marrow transplantation did not predict the occurrence of aGVHD.
Rosenzwajg
Michelle
M
Université Pierre et Marie Curie-Paris 6, Paris, France.
Dhédin
Nathalie
N
Maury
Sébastien
S
Bensimon
Gilbert
G
Landau
Dan Avi
DA
Norol
Françoise
F
Trébéden-Negre
Hélène
H
Uzunov
Madalina
M
Vernant
Jean-Paul
JP
Klatzmann
David
D
Cohen
José L
JL
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D015704:CD4 Antigens / Q000378:metabolism; D002452:Cell Count; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000453:epidemiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006648:Histocompatibility; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D035781:Siblings; D050378:T-Lymphocytes, Regulatory; D055815:Young Adult
D015704:CD4 Antigens