title: Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism.
abstract: A human intestinal bacterium, strain END-2, which enantioselectively oxidizes (+)-enterodiol (END) to (+)-enterolactone (ENL) through enterolactol is also responsible for demethylation during plant lignan metabolism. A free hydroxyl group adjacent to the methoxy group is required for demethylation. The bacterium transformed (+)- and (-)-secoisolariciresinol to (+)-ENL and (-)-END, respectively, by co-incubation with strain ARC-1, which is responsible for dehydroxylation.
authors.affiliation: Institute of Natural Medicine, University of Toyama, Toyama, Japan.
authors.forename: Jong-Sik
authors.initials: JS
authors.lastname: Jin
authors.forename: Masao
authors.initials: M
authors.lastname: Hattori
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D001421:Bacteria, Anaerobic / Q000254:growth & development / Q000378:metabolism*; D001711:Biotransformation; D002072:Butylene Glycols / Q000737:chemistry / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D017705:Lignans / Q000737:chemistry / Q000378:metabolism*; D013058:Mass Spectrometry; D008745:Methylation; D015394:Molecular Structure; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D002072:Butylene Glycols; D017705:Lignans; C029498:2,3-bis(3'-hydroxybenzyl)butane-1,4-diol; C060283:secoisolariciresinol; D015107:4-Butyrolactone; C029497:2,3-bis(3'-hydroxybenzyl)butyrolactone