Formulation of creams with betamethasone dipropionate: evaluation of chemical stability.
The aim of this study was to investigate how the different excipients influenced the chemical stability of betamethasone dipropionate in creams. The chemical stability was evaluated by analyzing betamethasone related substance content. Transcutol is the excipient ensuring maximum stability to betamethasone. Incompatibilities between betamethasone dipropionate and hexylene glycol were observed. The pH values in the weak acid range confer chemical stability to betamethasone.
Băiţan
Mariana
M
Gr. T. Popa University of Medicine and Pharmacy, Iaşi School of Pharmacy, Department of Pharmaceutical Technology Antibiotice S. A. Iaşi.
Gafiţanu
Eliza
E
Lionte
Mihaela
M
Moisuc
Lăcrămioara
L
D001623:Betamethasone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003879:Dermatologic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004355:Drug Stability; D005026:Ethylene Glycols / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009824:Ointments / Q000138:chemical synthesis
D003879:Dermatologic Agents; D005026:Ethylene Glycols; D005079:Excipients; D009824:Ointments; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; C010111:carbitol