Skin autofluorescence as marker of tissue advanced glycation end-products accumulation in formerly preeclamptic women.
CONCLUSIONS
In women with a history of preeclampsia skin autofluorescence as marker of tissue AGEs accumulation is increased, supporting a common causal metabolic or vascular link between preeclampsia and cardiovascular diseases.


OBJECTIVE
To investigate whether skin autofluorescence (AF), as marker of tissue accumulation of advanced glycation end-products (AGEs), is elevated in women with a 4-year history of severe preeclampsia.


METHODS
About 17 formerly preeclamptic women and 16 controls were included. Skin AF and several traditional cardiovascular risk factors were recorded.


RESULTS
In comparison to controls, formerly preeclamptic women had higher skin AF of the legs, body mass index (BMI), blood pressure, and high-sensitivity C-reactive protein (hsCRP), HbA1C, and triglycerides in serum.


CONCLUSIONS
Skin AF as well as cardiovascular risk factors is elevated in formerly preeclamptic women. These results suggest a common causal vascular link between preeclampsia and cardiovascular diseases.
Coffeng
Sophie M
SM
Department of Obstetrics and Gynecology, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands. s.m.coffeng@student.rug.nl
Blaauw
Judith
J
Souwer
Esteban T D
ET
Rakhorst
Gerhard
G
Smit
Andries J
AJ
Graaff
Reindert
R
van Doormaal
Jasper J
JJ
Aarnoudse
Jan G
JG
Faas
Marijke M
MM
van Pampus
Maria G
MG
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism; D005260:Female; D005453:Fluorescence; D005500:Follow-Up Studies; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D011225:Pre-Eclampsia / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012307:Risk Factors; D012867:Skin / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D015415:Biomarkers; D017127:Glycation End Products, Advanced