title: Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
abstract: Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
authors.affiliation: Department of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. abehan@rcsi.ie
authors.forename: Aine T
authors.initials: AT
authors.lastname: Behan
authors.forename: Daniel L A
authors.initials: DL
authors.lastname: van den Hove
authors.forename: Lynn
authors.initials: L
authors.lastname: Mueller
authors.forename: Marlon J A
authors.initials: MJ
authors.lastname: Jetten
authors.forename: Harry W M
authors.initials: HW
authors.lastname: Steinbusch
authors.forename: David R
authors.initials: DR
authors.lastname: Cotter
authors.forename: Jos
authors.initials: J
authors.lastname: Prickaerts
mesh_terms: D000818:Animals; D001007:Anxiety / Q000473:pathology; D001522:Behavior, Animal; D003071:Cognition; D003345:Corticosterone / Q000097:blood; D003863:Depression / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D051379:Mice; D019964:Mood Disorders / Q000473:pathology; D009457:Neuroglia / Q000473:pathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012727:Sex Characteristics; D013315:Stress, Psychological
chemical_list: D003345:Corticosterone