Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update.
Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde's syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias.
Gola
Wojciech
W
Department of Cardiology, Sterling Memorial University Hospital, Medical University of Łódź, Sterlinga 1/3, Łódź, Poland. golawojtek@gmail.com
Lelonek
Małgorzata
M
D016888:Angiodysplasia / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000601:surgery; D001777:Blood Coagulation; D016099:Endoscopy, Gastrointestinal; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007410:Intestinal Diseases / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000601:surgery; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D014841:von Willebrand Factor / Q000378:metabolism
D014841:von Willebrand Factor