title: Regulatory T cell content in the bone marrow graft does not predict the occurrence of acute GVHD.
abstract: The subpopulation of regulatory T cells (Treg) was shown to play a key role in alloreactive responses. In allogeneic hematopoietic stem cell transplantation, several groups tested whether Treg content in transplants correlates with graft-versus-host disease (GVHD) with controversial results. In a retrospective study of 49 consecutive HLA-matched sibling transplantations, we studied the relationship between Treg content in bone marrow transplants and acute GVHD (aGVHD) occurrence. We observed a large variability in Treg in bone marrow grafts. However, contrary to previous observations in peripheral blood stem cells transplantation, we report that the Treg content of allogeneic bone marrow transplantation did not predict the occurrence of aGVHD.
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Paris, France.
authors.forename: Michelle
authors.initials: M
authors.lastname: Rosenzwajg
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dhédin
authors.forename: Sébastien
authors.initials: S
authors.lastname: Maury
authors.forename: Gilbert
authors.initials: G
authors.lastname: Bensimon
authors.forename: Dan Avi
authors.initials: DA
authors.lastname: Landau
authors.forename: Françoise
authors.initials: F
authors.lastname: Norol
authors.forename: Hélène
authors.initials: H
authors.lastname: Trébéden-Negre
authors.forename: Madalina
authors.initials: M
authors.lastname: Uzunov
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Vernant
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
authors.forename: José L
authors.initials: JL
authors.lastname: Cohen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D015704:CD4 Antigens / Q000378:metabolism; D002452:Cell Count; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000453:epidemiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006648:Histocompatibility; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D035781:Siblings; D050378:T-Lymphocytes, Regulatory; D055815:Young Adult
chemical_list: D015704:CD4 Antigens