[Adaptation of antioxidative system in rat kidneys under varying light conditions during tetrachloromethane intoxication and effect of melatonin].
The influence of varying light conditions of the state of pro- and antioxidative systems in rat kidneys has been studied. The lowest level of free radical oxidation of lipids and proteins and the highest activity of catalase and glutathione peroxidase in the rat kidneys was established in case of maximal duration of the light day. Under different light conditions the increase of malonic aldehyde and oxidatively modified proteins in the rat kidneys in case of tetrachloromethane intoxication was shown as compared with the control. It was established, that melatonin introduction during 5 days in a doze of 3.0 mg/kg of body weight reduces the content of products of free radical oxidation of lipids and proteins and shows the normalizing effect on the indices of antioxidative system in rat kidneys.
Mats'opa
I V
IV
Hryhor'ieva
N P
NP
Meshchyshen
I F
IF
D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D008027:Light; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D002251:Carbon Tetrachloride; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D008550:Melatonin