Dynamics of early estradiol production may be associated with outcomes of in vitro fertilization.
This study investigated the effects of total E(2) production during controlled ovarian stimulation (COS) calculated by "modified area under the curve for E(2) (AUC-E(2))" and of the changes in E(2) level during the initial stimulation period calculated as "slope of initial increase in E(2) (Sl-E(2))" on the outcomes of IVF cycles using GnRH antagonist protocols. The findings suggest that the rate of initial increase in E(2) rather than total E(2) production during COS might affect the competence of retrieved oocytes in GnRH antagonist cycles.
Kim
Yong Jin
YJ
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, South Korea.
Ku
Seung-Yup
SY
Jee
Byung Chul
BC
Suh
Chang Suk
CS
Kim
Seok Hyun
SH
Choi
Young Min
YM
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D019540:Area Under Curve; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D007700:Kinetics; D008954:Models, Biological; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol