title: Protruding and non-protruding colon carcinomas originating in gut-associated lymphoid tissue.
abstract: BACKGROUND
  Colon carcinomas arising in gut-associated lymphoid tissue (GALTC) are termed dome carcinomas (DC) because of their protruding phenotype. Only 8 GALTC cases have been reported in the literature.
  
  
  METHODS
  A female patient, aged 53, having a familial pedigree of colon cancer, uterine cervix cancer and brain tumour developed a signet-ring carcinoma in the cecum and 10 years later endometrial cancer. While asymptomatic, a plaque-like protrusion in the colon was detected at surveillance colonoscopy. Histology demonstrated a protruding GALTC. The surgical specimen showed four additional carcinomas: 2 GALTC (non-protruding) and 2 carcinomas in lymphoid-free colonic mucosa (LFCMC).
  
  
  CONCLUSIONS
  Since adenomas could not be demonstrated neither previously nor in the colectomy specimen, it is suggested that the GALTCs in this patient may have followed the GALT-carcinoma pathway.
authors.affiliation: Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden. Carlos.Rubio@ki.se
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Rubio
authors.forename: Claes
authors.initials: C
authors.lastname: Lindh
authors.forename: Jan
authors.initials: J
authors.lastname: Björk
authors.forename: Hans
authors.initials: H
authors.lastname: Törnblom
authors.forename: Ragnar
authors.initials: R
authors.lastname: Befrits
mesh_terms: D003110:Colonic Neoplasms / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008221:Lymphoid Tissue / Q000473:pathology*; D008875:Middle Aged