Predictive factors of non-deterioration of glucose tolerance following a 2-year behavioral intervention.
OBJECTIVE
To identify predictive factors associated with non-deterioration of glucose metabolism following a 2-year behavioral intervention in Japanese-Brazilians.


METHODS
295 adults (59.7% women) without diabetes completed 2-year intervention program. Characteristics of those who maintained/improved glucose tolerance status (non-progressors) were compared with those who worsened (progressors) after the intervention. In logistic regression analysis, the condition of non-progressor was used as dependent variable.


RESULTS
Baseline characteristics of non-progressors (71.7%) and progressors were similar, except for the former being younger and having higher frequency of disturbed glucose tolerance and lower C-reactive protein (CRP). In logistic regression, non-deterioration of glucose metabolism was associated with disturbed glucose tolerance - impaired fasting glucose or impaired glucose tolerance - (p < 0.001) and CRP levels </= 0.04 mg/dL (p = 0.01), adjusted for age and anthropometric variables. Changes in anthropometry and physical activity and achievement of weight and dietary goals after intervention were similar in subsets that worsened or not the glucose tolerance status.


CONCLUSIONS
The whole sample presented a homogeneous behavior during the intervention. Lower CRP levels and diagnosis of glucose intolerance at baseline were predictors of non-deterioration of the glucose metabolism after a relatively simple intervention, independent of body adiposity.
Almeida-Pititto
Bianca
B
Department of Nutrition, School of Public Health, University of Sao Paulo-Av, Dr, Arnaldo, 715, CEP 01246-904, São Paulo-SP, Brazil. sandrafv@usp.br.
Hirai
Amélia T
AT
Sartorelli
Daniela S
DS
Harima
Helena A
HA
Gimeno
Suely Ga
SG
Ferreira
Sandra Rg
SR