title: Inflammatory bowel disease and pregnancy: report of two cases treated with infliximab and a review of the literature.
abstract: Inflammatory bowel disease is relatively frequent in women of childbearing age. Disease management requires greater attention during this clinical condition because of potential risk of maternal-fetal complications. Infliximab has been shown to be safe during pregnancy and lactation, but reports in the literature are scarce. We report two cases of refractory Crohn's disease treated with infliximab with good results, in women. Both patients became pregnant during maintenance regimen and treatment was continued. The literature regarding pregnant patients with inflammatory bowel disease was reviewed.
authors.affiliation: Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil. lpmpcorreia@gmail.com
authors.forename: Lucianna Motta
authors.initials: LM
authors.lastname: Correia
authors.forename: Danielle Queiroz
authors.initials: DQ
authors.lastname: Bonilha
authors.forename: Juliana Dantas
authors.initials: JD
authors.lastname: Ramos
authors.forename: Orlando
authors.initials: O
authors.lastname: Ambrogini
authors.forename: Sender Jankiel
authors.initials: SJ
authors.lastname: Miszputen
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006801:Humans; D000069285:Infliximab; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab