title: Localized retinal nerve fiber layer defects associated with cotton wool spots.
abstract: OBJECTIVE
  To introduce four cases of localized retinal nerve fiber layer (RNFL) defects after emergence of retinal cotton wool spots (CWSs).
  
  
  METHODS
  Four patients were evaluated for localized RNFL defects after the appearance of CWSs. Depending on the patient, they were followed up from the beginning of treatment to up to 19 years after the initial events. Fundus photos and other glaucoma examinations, including Stratus optical coherence tomography (OCT) and visual field examinations, were performed during the follow-up visits.
  
  
  RESULTS
  The localized RNFL defects remained stable without any progression for as long as 19 years.
  
  
  CONCLUSIONS
  Nonprogressive RNFL defects may occur after the appearance of CWSs, which the examiner may not be able to detect. Clinicians may need to consider not only visual field results and OCT findings but also disc configuration, RNFL defects, and fundus findings to decide on the proper diagnosis and treatment of patients suspected to have glaucoma.
authors.affiliation: Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea.
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Koh
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Mo Sae
authors.initials: MS
authors.lastname: Kim
authors.forename: Joon Mo
authors.initials: JM
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D010781:Photography; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014794:Visual Fields