title: Structure and orientation of water at charged lipid monolayer/water interfaces probed by heterodyne-detected vibrational sum frequency generation spectroscopy.
abstract: Cell membrane/water interfaces provide a unique environment for many biochemical reactions, and associated interfacial water is an integral part of such reactions. A molecular level understanding of the structure and orientation of water at lipid/water interfaces is required to realize the complex chemistry at biointerfaces. Here we report the heterodyne-detected vibrational sum frequency generation (HD-VSFG) studies of lipid monolayer/water interfaces. At charged lipid/water interfaces, the orientation of interfacial water is governed by the net charge on the lipid headgroup; at an anionic lipid/water interface, water is in the hydrogen-up orientation, and at the cationic lipid/water interface, water is in the hydrogen-down orientation. At the cationic and anionic lipid/water interfaces, interfacial water has comparable hydrogen bond strength, and it is analogous to the bulk water.
authors.affiliation: Molecular Spectroscopy Laboratory, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
authors.forename: Jahur A
authors.initials: JA
authors.lastname: Mondal
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nihonyanagi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Tahei
authors.initials: T
authors.lastname: Tahara
mesh_terms: D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry*
chemical_list: D008055:Lipids; D014867:Water