Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates.
This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.
Ramis
Ivy Bastos
IB
Laboratório de Biologia Molecular, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
Fonseca
Tesiê Leopoldo
TL
de Moraes
Ernani Pinho
EP
Fernandes
Márcia Silveira
MS
Mendoza-Sassi
Raul
R
Rodrigues
Obirajara
O
Juliano
Carlos Renan Varela
CR
Scaini
Carlos James
CJ
da Silva
Pedro Eduardo Almeida
PE
D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D016133:Polymerase Chain Reaction; D037521:Virulence Factors / Q000235:genetics*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori; C063113:ice nucleation protein