title: Evaluation of left ventricular function with strain/strain rate imaging in patients with rheumatic mitral stenosis.
abstract: OBJECTIVE
  The most important sequel of acute rheumatic fever is mitral stenosis in long-term. The aim of the study is to determine left ventricular (LV) functions by tissue Doppler imaging (TDI) and strain/strain rate echocardiography (SE/SRE) in mitral stenosis patients who had no clinical signs of heart failure.
  
  
  METHODS
  Our study was designed as cross-sectional study. The study population consisted of 32 patients with isolated mitral stenosis and mitral valve area = 2.0 cm(2) (Group 1) and 25 healthy control subjects (Group 2). In addition to standard echocardiographic methods, TDI and SE/SRE were performed to assess LV functions in all participants. Student's t-test was used to compare continuous variables. Fisher- exact test was used to compare categorical variables.
  
  
  RESULTS
  Systolic myocardial velocity (Sm) were significantly lower in Group 1 than in Group 2 (6.0+/-1.4 cm/sec vs 7.9+/-1.8 cm/sec, p=0.001) also, early diastolic myocardial velocity (Em) were significantly lower in Group 1 than in Group 2 (4.4+/-1.5 cm/sec vs 10.8+/-2.1 cm/sec, p=0.001). But there was no significant difference in late diastolic myocardial velocity (Am) between two groups. Peak systolic strain and strain rate of septal wall in Group 1 were significantly lower than Group 2 (p=0.001 for both). Besides, peak systolic strain and strain rate of lateral wall in Group 1 were significantly lower than in Group 2 (p=0.001 for both).
  
  
  CONCLUSIONS
  Although, global ejection fraction was normal and there were no symptoms of heart failure clinically in the patients with mitral stenosis, LV dysfunction demonstrated that using by echocardiography. TDI and strain/strain rate imaging to be new echocardiographic methods may be used reliably for detection LV function in early stage of mitral stenosis.
authors.affiliation: Department of Cardiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. ziyamposta@hotmail.com
authors.forename: Ziya
authors.initials: Z
authors.lastname: Simşek
authors.forename: Sule
authors.initials: S
authors.lastname: Karakelleoğlu
authors.forename: Fuat
authors.initials: F
authors.lastname: Gündoğdu
authors.forename: Enbiya
authors.initials: E
authors.lastname: Aksakal
authors.forename: Serdar
authors.initials: S
authors.lastname: Sevimli
authors.forename: Sakir
authors.initials: S
authors.lastname: Arslan
authors.forename: Yekta
authors.initials: Y
authors.lastname: Gürlertop
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Senocak
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D012016:Reference Values; D012213:Rheumatic Fever / Q000150:complications*; D012720:Severity of Illness Index; D013599:Systole / Q000502:physiology