Host and graft thickness after Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophy.
OBJECTIVE
To determine relationships between vision, forward scatter, and total corneal and graft thicknesses after Descemet stripping endothelial keratoplasty (DSEK).


METHODS
Prospective, cohort study.


METHODS
Forty-four eyes with Fuchs endothelial dystrophy were examined before and at 1, 3, 6, and 12 months after DSEK; all eyes were pseudophakic after surgery. Central total corneal and graft thicknesses were measured using confocal microscopy. Best-corrected high-contrast visual acuity (BCVA) was measured using the electronic Early Treatment Diabetic Retinopathy Study protocol, and forward light scatter was measured using a straylight meter.


RESULTS
Total corneal thickness was 610 ± 50 μm (mean ± standard deviation) before DSEK, increased to 680 ± 74 μm by 1 month after DSEK (P < .001), and stabilized at 660 ± 68 μm by 3 months after DSEK (P = .03 vs 1 month). Graft thickness was 170 ± 57 μm at 1 month, decreased to 157 ± 49 μm by 3 months (P = .004), and then remained stable through 12 months (156 ± 51 μm; P = .99 vs 3 months). BCVA was 0.44 ± 0.21 logarithm of the minimal angle of resolution (logMAR) units (Snellen equivalent, 20/55) before DSEK, improved to 0.26 ± 0.20 logMAR units (Snellen equivalent, 20/36) by 3 months (P < .001), and improved to 0.16 ± 0.16 logMAR units (Snellen equivalent, 20/29) at 12 months (P < .001 vs 3 months). BCVA and forward light scatter did not correlate with corneal or graft thickness after DSEK.


CONCLUSIONS
Stromal edema resolves by 3 months after DSEK for Fuchs dystrophy, whereas visual acuity continues to improve through 12 months. Thicker corneas and grafts are not associated with worse visual acuity or increased forward scatter.
Ahmed
Kamran A
KA
Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.
McLaren
Jay W
JW
Baratz
Keith H
KH
Maguire
Leo J
LJ
Kittleson
Katrina M
KM
Patel
Sanjay V
SV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D001837:Body Weights and Measures; D015331:Cohort Studies; D003315:Cornea / Q000473:pathology; D057111:Descemet Stripping Endothelial Keratoplasty; D004728:Endothelium, Corneal / Q000473:pathology* / Q000637:transplantation; D005500:Follow-Up Studies; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery*; D006801:Humans; D018613:Microscopy, Confocal; D008875:Middle Aged; D016377:Organ Transplantation; D011446:Prospective Studies; D014792:Visual Acuity / Q000502:physiology