Kaempferol enhanced the intracellular thioredoxin system in normal cultured human keratinocytes.
The effects of kaempferol on redox-associated enzymes in normal human keratinocytes were studied. It enhanced the gene expression of thioredoxin reductase 1 and thioredoxin. Flavonols had higher ability to induce the expression of these genes than the other anti-oxidants and the other flavonoids tested. Furthermore, kaempferol and quercetin increased the activity of thioredoxin reductase in normal human keratinocytes.
Sugahara
Misato
M
Shiseido Research Center, Hayabuchi, Tsuzuki-ku, Yokohama, Japan.
Nakanishi
Jotaro
J
Katsuta
Yuji
Y
D002478:Cells, Cultured; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D044949:Kaempferols / Q000494:pharmacology*; D015603:Keratinocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D013879:Thioredoxins / Q000378:metabolism*
D044949:Kaempferols; D013879:Thioredoxins; C006552:kaempferol