title: Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus.
abstract: BACKGROUND
  It is necessary to assay multiple autoantibodies simultaneously in the same group of new-onset systemic lupus erythematosus (SLE) patient.
  
  
  OBJECTIVE
  To determine the prevalence and clinical significance of 15 autoantibodies in patients with new-onset SLE.
  
  
  METHODS
  Twenty new-onset patients with SLE and 32 healthy individuals were enrolled in the present study. Serum levels of 15 autoantibodies were detected by enzyme linked immunosorbent assay. The clinical parameters of the patients were also recorded.
  
  
  RESULTS
  The positive rate of anti-ssDNA was the highest (85%). The positive rates of anti-dsDNA, anti-ssDNA, AHA, anti-SSA, anti-SSB, anti-Sm, anti-U1RNP, AnuA, and rRNP were significantly higher in SLE patients than in nomal controls. In terms of clinical manifestation, there were significant associations of rRNP with photaesthesia and of AHA with nephritis.
  
  
  CONCLUSIONS
  Clusters of autoantibodies were identified and associations of antibodies with symptoms were found in new-onset patients with SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
authors.forename: W-X
authors.initials: WX
authors.lastname: Li
authors.forename: H-F
authors.initials: HF
authors.lastname: Pan
authors.forename: L-H
authors.initials: LH
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: Y-G
authors.initials: YG
authors.lastname: Fan
authors.forename: J-B
authors.initials: JB
authors.lastname: Feng
authors.forename: X-W
authors.initials: XW
authors.lastname: Tang
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: X-P
authors.initials: XP
authors.lastname: Li
authors.forename: D-Q
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D004247:DNA / Q000276:immunology; D004277:DNA, Single-Stranded / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D004277:DNA, Single-Stranded; D004247:DNA