Insights into the phylogeny or arylamine N-acetyltransferases in fungi.
Previous studies have shown that Eumycetes fungi can acylate arylamine thanks to arylamine N-acetyltransferases, xenobiotic-metabolizing enzymes also found in animals and bacteria. In this article, we present the results of mining 96 available fungal genome sequences for arylamine N-acetyltransferase genes and propose their phylogeny. The filamentous Pezizomycotina are shown to possess many putative N-acetyltransferases, whilst these are often lacking in other fungal groups. The evolution of the N-acetyltransferases is best explained by the presence of at least one gene in the opisthokont ancestor of the fungi and animal kingdoms, followed by recurrent gene losses and gene duplications. A possible horizontal gene transfer event may have occurred from bacteria to the basidiomycetous yeast Malassezia globosa.
Martins
Marta
M
Univ Paris Diderot-Paris 7, Unité de Biologie Fonctionnelle et Adaptative (BFA), CNRS EAC 4413, Laboratoire des Réponses Moléculaires et Cellulaires aux Xénobiotiques, 75013, Paris, France.
Dairou
Julien
J
Rodrigues-Lima
Fernando
F
Dupret
Jean-Marie
JM
Silar
Philippe
P
D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D001203:Ascomycota / Q000201:enzymology / Q000235:genetics; D019295:Computational Biology; D005656:Fungal Proteins / Q000235:genetics; D005658:Fungi / Q000201:enzymology* / Q000235:genetics*; D022761:Gene Transfer, Horizontal / Q000502:physiology; D016681:Genome, Fungal; D016013:Likelihood Functions; D010802:Phylogeny
D005656:Fungal Proteins; D001191:Arylamine N-Acetyltransferase