title: Host-guest system of nimbin and beta-cyclodextrin or its derivatives: preparation, characterization, inclusion mode, and solubilization.
abstract: The inclusion complexation behavior, characterization, and binding ability of nimbin with beta-cyclodextrin (beta-CD) and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, (1)H and 2D NMR, and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of nimbin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the nimbin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Sheng-Jiao
authors.initials: SJ
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D031601:Azadirachta / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D006358:Hot Temperature; D036701:Limonins / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012995:Solubility; D013816:Thermodynamics
chemical_list: D003505:Cyclodextrins; D036701:Limonins; D010936:Plant Extracts; C008621:nimbin