title: [Present status of pediatric living-donor liver transplantation in National Center for Child Health and Development].
abstract: OBJECTIVE
  We reviewed our initial experience of pediatric living-donor liver transplantation (LDLT) in National Center for Child Health and Development and report the results herein.
  
  
  METHODS
  We have done 103 cases of LDLT during November 2005 through September 2009 in National Center for Child Health and Development. Variables including indication of liver transplantation/infectious/immunological outcome were reviewed.
  
  
  RESULTS
  The indication for liver transplantation was cholestatic liver disease in 43.76%, followed by metabolic liver disease 24.3% and acute liver failure 18.5%. The mean age of recipient was 3.6 +/- 4.2 years and body weight was 14.4 +/- 11.1kg. Immunosuppression consisted of tacrolimus and low-dose steroids. The incidence of acute cellular rejection was 33.3%. The graft and patient survival were 92.2%.
  
  
  CONCLUSIONS
  Satisfactory result can be achieved on LDLT program in National Center for Child Health and Development. The follow-up period was too short to make definitive conclusion, however, long-term observation may be necessary to collect sufficient data for the establishment of the treatment modality.
authors.affiliation: Transplantation Surgery, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Mureo
authors.initials: M
authors.lastname: Kasahara
authors.forename: Seisuke
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Takanobu
authors.initials: T
authors.lastname: Shigeta
authors.forename: Akinari
authors.initials: A
authors.lastname: Fukuda
authors.forename: Naoto
authors.initials: N
authors.lastname: Matsuno
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kitano
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kuroda
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000209:etiology; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors; D011183:Postoperative Complications; D016896:Treatment Outcome