Emphysema as a risk factor for the outcome of surgical resection of lung cancer.
It is unclear whether emphysema, regardless of airflow limitation, is a predictive factor associated with survival after lung cancer resection. Therefore, we investigated whether emphysema was a risk factor associated with the outcome after resection for lung cancer. This study enrolled 237 patients with non small cell lung cancer with stage I or II who had surgical removal. Patient outcome was analyzed based on emphysema. Emphysema was found in 43.4% of all patients. Patients with emphysema were predominantly men and smokers, and had a lower body mass index than the patients without emphysema. The patients without emphysema (n=133) survived longer (mean 51.2+/-3.0 vs. 40.6+/-3.1 months, P=0.042) than those with emphysema (n=104). The univariate analysis showed a younger age, higher FEV(1)/FVC, higher body mass index, cancer stage I, and a lower emphysema score were significant predictors of better survival. The multivariate analysis revealed a younger age, higher body mass index, and cancer stage I were independent parameters associated with better survival, however, emphysema was not. This study suggests that unfavorable outcomes after surgical resection of lung cancer should not be attributed to emphysema itself.
Lee
Sung Ah
SA
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sun
Joo Sung
JS
Park
Joo Hun
JH
Park
Kyung Joo
KJ
Lee
Sung Soo
SS
Choi
Ho
H
Sheen
Seung Soo
SS
Chung
Woo Young
WY
Lee
Keu Sung
KS
Park
Kwang Joo
KJ
Hwang
Sung Chul
SC
D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000401:mortality / Q000601:surgery*; D004646:Emphysema / Q000150:complications*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012307:Risk Factors; D012907:Smoking; D015996:Survival Rate