Graft-induced dyskinesias in Parkinson's disease: what is it all about?
The treatment of Parkinson's disease with grafts of fetal ventral mesencephalic tissue has shown some success, but can result in graft-induced dyskinesias (GIDs). Recently in Science Translational Medicine, Politis et al. (2010) demonstrate that GIDs may originate from serotoninergic neurons that are cografted in these transplants.
Barker
Roger A
RA
Brain Repair Centre and Department of Neurology, University of Cambridge, Cambridge CB2 0PY, UK. rab46@cam.ac.uk
Kuan
Wei-Li
WL
D000818:Animals; D016380:Brain Tissue Transplantation / Q000009:adverse effects*; D002065:Buspirone / Q000627:therapeutic use; D020820:Dyskinesias / Q000188:drug therapy / Q000209:etiology*; D016332:Fetal Tissue Transplantation / Q000009:adverse effects*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications* / Q000601:surgery*; D012701:Serotonin / Q000378:metabolism; D033581:Stem Cell Transplantation
D012701:Serotonin; D002065:Buspirone