[Recent advances in studies on autosomal dominant adult polycystic kidney disease].
Adult polycystic kidney disease (APKD) is a severe autosomal dominant inheritable renal disease with high incidence. Because of the late-onset of the disease, patients might have transferred the disease gene to the next generation when diagnosis is made. Since its pathogenic molecular mechanism is still not completely clear and the shortage of effective medicines, the prevention and treatment of the disease is still not satisfactory. In the present article, the recent advances in the research on the pathogenesis, gene diagnosis and management of APKD are reviewed.
Yu
Chao-wen
CW
Department of Medical Genetics, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 PR China.
Zhang
Si-zhong
SZ
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D012106:Research; D050396:TRPP Cation Channels / Q000235:genetics*
D050396:TRPP Cation Channels