Acupuncture accelerates wound healing in burn-injured mice.
The effects of acupuncture on healing of deep second degree burns were compared to the conventional hydrocolloid dressing, Duoderm in mice. The expression level of inflammatory protein-1α (MIP-1α) was significantly reduced in the injured skin and the number of eosinophils in blood decreased significantly following the acupuncture treatment compared to the Duoderm dressing at 7 days after the burn. In addition, the acupuncture treatment was more effective in decreasing the wound size and inducing epidermal regeneration. Histological findings also revealed that there was less leukocyte infiltration and a greater reduction in the immunohistochemical reaction to MIP-2 in the wounds treated with acupuncture versus Duoderm. Furthermore, the numbers of BrdU- and basic fibroblast growth factor (bFGF)-positive cells were significantly increased by the acupuncture treatment, compared to the Duoderm treatment at 7 days. Moreover, in the acupuncture treated mice, the expression of fibronectin was increased and α-SMA was decreased at 7 days. Thus, this present study demonstrates that acupuncture accelerates the skin regeneration process following deep second degree burns.
Lee
Jin-Ah
JA
Department of Oriental Medicine, The Graduate School of Dongguk University, Gyeongbuk 780-714, Republic of Korea.
Jeong
Ha Jin
HJ
Park
Hi-Joon
HJ
Jeon
Songhee
S
Hong
Seung-Ug
SU
D000199:Actins / Q000378:metabolism; D026881:Acupuncture; D000818:Animals; D047070:Bandages, Hydrocolloid; D002056:Burns / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D049109:Cell Proliferation; D054405:Chemokine CCL3 / Q000378:metabolism; D054426:Chemokine CXCL2 / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005353:Fibronectins / Q000378:metabolism; D020869:Gene Expression Profiling; D007150:Immunohistochemistry; D007962:Leukocytes / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014945:Wound Healing / Q000502:physiology*
D000199:Actins; C496534:Ccl3 protein, mouse; D054405:Chemokine CCL3; D054426:Chemokine CXCL2; D016207:Cytokines; D005353:Fibronectins; C544013:alpha-smooth muscle actin, mouse