title: Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?
abstract: Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2beta. In the present study, we investigated TFAP-2beta protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2beta levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption. Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats.
authors.affiliation: Division of Pharmacology, Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Oreland
authors.forename: L
authors.initials: L
authors.lastname: Daoura
authors.forename: L
authors.initials: L
authors.lastname: Gustafsson-Ericson
authors.forename: M
authors.initials: M
authors.lastname: Damberg
authors.forename: P
authors.initials: P
authors.lastname: Hyytiä
authors.forename: L
authors.initials: L
authors.lastname: Oreland
authors.forename: Ingrid
authors.initials: I
authors.lastname: Nylander
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008426:Maternal Deprivation; D051381:Rats; D017208:Rats, Wistar; D012931:Social Environment; D050656:Transcription Factor AP-2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D050656:Transcription Factor AP-2; D000431:Ethanol