title: Eosinophilic ulcer of the oral mucosa: report of a child with CD30-negative cells in an infiltration on the lower lip.
abstract: BACKGROUND
  Eosinophilic ulcer of the oral mucosa (EUOM), also known as traumatic eosinophilic granuloma or Rida-Fede disease, is an uncommon, benign and self-limited lesion of the oral mucous membrane. The tongue is the most common location of EUOM, accounting for up to 60% of the cases, with the lateral and dorsal surfaces being principally affected. EUOM clinically manifests as a painful, nodular inflammatory infiltration, usually with ulceration. Characteristic histological findings consist of dense subepithelial, mixed inflammatory infiltration with numerous eosinophils. The etiology of the disease is unknown.
  
  
  METHODS
  We present a case of a 9-year-old boy, in whom a painful ulceration, nonresponding to typical antiviral and antibacterial treatment, occurred on the lower lip. The histological study revealed intact epithelium without the unequivocal signs of cellular atypia and a dense infiltrate in the stroma mainly composed of eosinophils and histiocytes with CD30-negative cells. The histological diagnosis of EUOM was given. A rapid resolution of the lesion was observed following biopsy.
  
  
  CONCLUSIONS
  EUOM, a relatively rare and benign disease, infrequently presenting as a lesion on lips, may cause diagnostic difficulties to dermatologists as well as to dental surgeons and ENT specialists. Biopsy is recommended to rule out malignant etiology and avoid overtreatment.
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Misterska
authors.forename: Marian
authors.initials: M
authors.lastname: Dmochowski
authors.forename: Joanna
authors.initials: J
authors.lastname: Szulczyńska-Gabor
authors.forename: Hanna
authors.initials: H
authors.lastname: Walkowiak
authors.forename: Monika
authors.initials: M
authors.lastname: Bowszyc-Dmochowska
authors.forename: Janusz
authors.initials: J
authors.lastname: Kaczmarek
authors.forename: Ryszard
authors.initials: R
authors.lastname: Zaba
mesh_terms: D002648:Child; D004802:Eosinophilia / Q000473:pathology*; D004803:Eosinophilic Granuloma / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism*; D008046:Lip / Q000473:pathology*; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology*; D014456:Ulcer / Q000473:pathology*
chemical_list: D017730:Ki-1 Antigen