title: [Warfarin hipersensitivity: how to deal with it?].
abstract: The authors report a clinical case of warfarin hypersensitivity noticed when a patient, with thromboembolic risk, was submitted to warfarin. She was found to be heterozigotic to -1639G>A (gene VKORC1) and homozygotic to 1075A>C (genotype CYP2C9*3/*3). In this article the warfarin pharmacodinamics and its role over Vitamin K is revisited. It includes some suggested indications for investigating genetic polymorphisms, in order to avoid complications associated with warfarin.
authors.affiliation: Serviço de Medicina Materno-Fetal, Maternidade Dr. Alfredo da Costa, Lisboa.
authors.forename: Ana Furtado
authors.initials: AF
authors.lastname: Lima
authors.forename: José
authors.initials: J
authors.lastname: Reis
authors.forename: Fátima
authors.initials: F
authors.lastname: Serrano
authors.forename: Augusta
authors.initials: A
authors.lastname: Borges
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin