title: Resolution of aviation forensic toxicology findings with the aid of DNA profiling.
abstract: Body components of aviation accident fatalities are often scattered, disintegrated, commingled, contaminated, and/or putrefied at accident scenes. These situations may impose difficulties in victim identification/tissue matching. The prevalence of misidentification in relation to aviation accident forensic toxicology has not been well established. Therefore, the Civil Aerospace Medical Institute (CAMI) toxicology database was searched for the 1998-2008 period for those cases wherein DNA profiling was performed to resolve identity issue of the samples submitted to CAMI for toxicological evaluation. During this period, biological samples from the casualties of a total of 3523 accidents were submitted to CAMI. The submitted samples were primarily from pilots. Out of the 3523 accidents, at least, one fatality had occurred in 3366 (≈ 96%) accidents; thus, these accidents were considered fatal accidents. Accordingly, biological samples from 3319 pilots (3319 of the 3366 accidents) were received at CAMI for toxicological testing. Of these 3319 pilots, 3275 (≈ 99%) were fatally injured. DNA profiling was performed in 15 (≈ 0.5%) of the 3319 accidents. The profiling was conducted upon the requests of families in two accidents, accident investigators in three, and pathologists in four. In six accidents, contradictory toxicological findings led CAMI to initiate DNA profiling. The requests made by families and investigators were primarily triggered by inconsistency between the toxicological results and the history of drug use of the victims, while by pathologists because of commingling of samples. In three (20%) of the 15 accidents, at least one submitted sample was misidentified or mislabeled. The present study demonstrated that the number of aviation accident cases requiring DNA profiling was small and this DNA approach was effectively applied in resolving aviation toxicology findings associated with those accidents.
authors.affiliation: Bioaeronautical Sciences Research Laboratory, AAM-610, Aerospace Medical Research Division, Civil Aerospace Medical Institute, Federal Aviation Administration, US Department of Transportation, PO Box 25082, Oklahoma City, OK 73125-5066, USA. arvind.chaturvedi@faa.gov
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Chaturvedi
authors.forename: Kristi J
authors.initials: KJ
authors.lastname: Craft
authors.forename: Doris M
authors.initials: DM
authors.lastname: Kupfer
authors.forename: Dennis
authors.initials: D
authors.lastname: Burian
authors.forename: Dennis V
authors.initials: DV
authors.lastname: Canfield
mesh_terms: D000060:Accidents, Aviation; D016172:DNA Fingerprinting; D019992:Databases as Topic; D049429:Forensic Pathology; D053593:Forensic Toxicology; D005819:Genetic Markers; D006801:Humans; D011786:Quality Control; D012732:Sex Determination Analysis; D015813:Substance Abuse Detection; D014481:United States
chemical_list: D005819:Genetic Markers