Polyarticular gout attacks following cerebrovascular accidents: is hemiparesis in fact protective? 2 cases and a review of the literature.
Cerebrovascular disease appears to have implications on rheumatic diseases, including gout. Accumulating evidence suggests that hemiparesis exerts a protective effect against gout via the down-regulation of mechanical and neural modulators of inflammation in neurologically impaired extremities. We present 2 divergent cases of unilateral gout following cerebrovascular events. One patient with a hemorrhagic stroke developed polyarticular gout only on the ipsilateral side to his hemiparesis, while another patient with basilar artery thrombosis and locked-in syndrome suffered a polyarticular gout flare only on the side that had regained limited function. As suggested by these cases, the effect of hemiparesis on gout is complex. Further insight into the interplay between gouty flares and hemiparesis may lead to novel therapeutic strategies for gout.
Hsiao
Susan J
SJ
New York University School of Medicine, New York University Langone Medical Center, New York, NY, USA.
Vaynrub
Maksim
M
Furer
Victoria
V
Samuels
Jonathan
J
D002490:Central Nervous System / Q000503:physiopathology; D006073:Gout / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000150:complications* / Q000503:physiopathology; D012216:Rheumatic Diseases / Q000517:prevention & control*; D020521:Stroke / Q000150:complications* / Q000503:physiopathology; D013927:Thrombosis / Q000150:complications* / Q000503:physiopathology; D014527:Uric Acid / Q000378:metabolism
D014527:Uric Acid