title: Click-xylosides mitigate glioma cell invasion in vitro.
abstract: Tumor related invasion allows cancers to spread beyond tissue boundaries and significantly affects patient prognosis. In this study we show that several click-xylosides markedly inhibit the invasive capability of a highly invasive glioma cell line in vitro. These novel xylosides are promising chemical biology tools to probe the role of the proteoglycan glycome in regulating tumor biology.
authors.affiliation: Department of Bioengineering, University of Utah, 30 S 2000 E, Skaggs Hall Room 307, Salt Lake City, Utah 84112, USA.
authors.forename: Karthik
authors.initials: K
authors.lastname: Raman
authors.forename: Balagurunathan
authors.initials: B
authors.lastname: Kuberan
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology*; D005910:Glioma / Q000473:pathology*; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000517:prevention & control*
chemical_list: D006027:Glycosides; C010807:xylosides