title: Synthesis of selenophene derivatives as novel CHK1 inhibitors.
abstract: A series of selenophene derivatives 3 were synthesized as potential CHK1 inhibitors. The effects of substitution on the 4'- or 5'-position of selenophene moiety and shifting the hydroxyl group position on C6- phenolic ring of oxindole were explored. This study led to the discovery of the most potent CHK1 inhibitors 29-33 and 39-43, which had IC(50) values in the subnanomolar range.
authors.affiliation: Development Center for Biotechnology, Xizhi City, Taipei County, Taiwan. pchong@mail.dcb.org.tw
authors.forename: Pao-Chiung
authors.initials: PC
authors.lastname: Hong
authors.forename: Li-Jung
authors.initials: LJ
authors.lastname: Chen
authors.forename: Tzu-Yun
authors.initials: TY
authors.lastname: Lai
authors.forename: Huei-Yu
authors.initials: HY
authors.lastname: Yang
authors.forename: Shih-Jan
authors.initials: SJ
authors.lastname: Chiang
authors.forename: Yann-Yu
authors.initials: YY
authors.lastname: Lu
authors.forename: Ping-Kuei
authors.initials: PK
authors.lastname: Tsai
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Hsu
authors.forename: Win-Yin
authors.initials: WY
authors.lastname: Wei
authors.forename: Chu-Bin
authors.initials: CB
authors.lastname: Liao
mesh_terms: D000071877:Checkpoint Kinase 1; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011494:Protein Kinases / Q000187:drug effects*; D018036:Selenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D047428:Protein Kinase Inhibitors; D018036:Selenium Compounds; D011494:Protein Kinases; D000071877:Checkpoint Kinase 1