title: Fluorides leaching from restorative materials and the effect on adjacent teeth.
abstract: OBJECTIVE
  Placing a Class II restoration in a tooth changes the local environment, including that for the adjacent tooth. Apart from the change to a less- or non-cariogenic environment for the restored tooth, the effect of leachable components from a restoration in the adjacent tooth should be taken into consideration.
  
  
  METHODS
  Practice-based clinical studies comprising of 1341 unrestored proximal surfaces in contact with Class II restorations using different restorative materials were reviewed to assess the effect on the caries development on the adjacent teeth. The caries status of the adjacent un-restored proximal surface was assessed as being clinically sound, having active caries with or without cavitation, or having arrested caries. Restorations from nine clinicians were reviewed. They had attended annual meetings where all aspects of the investigation had been discussed. The surfaces were followed for up to eight years.
  
  
  RESULTS
  A reduced rate of caries development and progression were found on surfaces in contact with fluoride releasing materials like glass ionomers, resin modified glass ionomers and compomers compared to surfaces in contact with amalgam.
  
  
  CONCLUSIONS
  Fluoride releasing materials reduce the development and progression of primary caries on adjacent proximal surfaces.
authors.affiliation: Department of Cariology and Endodontics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen.
authors.forename: Vibeke
authors.initials: V
authors.lastname: Qvist
authors.forename: Agneta
authors.initials: A
authors.lastname: Poulsen
authors.forename: Poul Thorpen
authors.initials: PT
authors.lastname: Teglers
authors.forename: Ivar A
authors.initials: IA
authors.lastname: Mjör
mesh_terms: D000293:Adolescent; D002327:Cariostatic Agents / Q000737:chemistry* / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D020770:Compomers / Q000737:chemistry; D003723:Dental Amalgam / Q000737:chemistry; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D003764:Dental Materials / Q000737:chemistry*; D003793:Dental Restoration, Permanent / Q000145:classification; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D018450:Disease Progression; D005459:Fluorides / Q000737:chemistry* / Q000494:pharmacology; D005500:Follow-Up Studies; D005899:Glass Ionomer Cements / Q000737:chemistry; D006801:Humans; D008963:Molar / Q000187:drug effects / Q000473:pathology; D019279:Resin Cements / Q000737:chemistry; D014070:Tooth / Q000187:drug effects / Q000473:pathology; D014094:Tooth, Deciduous / Q000187:drug effects / Q000473:pathology
chemical_list: D002327:Cariostatic Agents; D020770:Compomers; D003764:Dental Materials; D005899:Glass Ionomer Cements; D019279:Resin Cements; D003723:Dental Amalgam; D005459:Fluorides