title: [Lymphocyte GRK2 expression of the very elderly with chronic heart failure].
abstract: OBJECTIVE
  To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).
  
  
  METHODS
  16 elderly patients with chronic heart failure were divided into 2 groups as following: EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.
  
  
  RESULTS
  Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.
  
  
  CONCLUSIONS
  Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.
authors.affiliation: Department 1 of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China. gwqbj08@sina.com
authors.forename: Wen-qian
authors.initials: WQ
authors.lastname: Gao
authors.forename: Jin-ling
authors.initials: JL
authors.lastname: Ma
authors.forename: Chun-guang
authors.initials: CG
authors.lastname: Han
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Ting-shu
authors.initials: TS
authors.lastname: Yang
mesh_terms: D000369:Aged, 80 and over; D002908:Chronic Disease; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000235:genetics / Q000378:metabolism*; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013318:Stroke Volume / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; C496567:GRK2 protein, human; D054769:G-Protein-Coupled Receptor Kinase 2