Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?
OBJECTIVE
Several studies suggested that Chlamydia pneumoniae (CP) infection may be a risk factor for cerebrovascular disease. Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (ACI) in Iranian patients.


METHODS
Forty-five patients admitted with ACI, and 45 control without ACI were enrolled in this case-control study. Using an enzyme-linked immunosorbed assay kit (ELISA), the presence of CP-immunoglobulin (CP-IgG) in studied patient's sera was determined.


RESULTS
The seroprevalence of CP-IgG was 35(77.7%) in the ACI group (mean age=73.3 years) and 29(64.4%) in the control group (mean age=70.1 years) (P>0.05). There was no difference in sex, age, hypertension, smoking, hyperlipidemia, diabetes and obesity between cases and control groups (P>0.05). No association was observed between CP seropositivity and ACI [OR: 1.95 (95% CI, 0.081-2.03), P=0.16].


CONCLUSIONS
Our finding suggests that there is no association between ACI and positive CP-IgG in Iranian patients.
Alavi
Seyed Mohammad
SM
Infectious disease ward, Razi Hospital, Ahvaz Joundishapour University of Medical Sciences, Ahvaz, Iran. alavi1329dr@yahoo.com
Ahmadi
Fatemeh
F
Abeshtan
Ahmad
A
D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000453:epidemiology*; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D023521:Chlamydophila Infections / Q000175:diagnosis / Q000453:epidemiology*; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D013927:Thrombosis / Q000453:epidemiology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G