Fluorous Mixture Synthesis of Four Stereoisomers of the C21-C40 Fragment of Tetrafibricin.
Four stereoisomers of the C21-C40 fragment are synthesized in a single exercise with the aid of fluorous tagging to encode configurations at C37 and C33. After demixing and detagging, the isomers were found to have substantially identical (1)H NMR spectra. However, there were some small but reliable differences in their (13)C NMR spectra.
Zhang
Kai
K
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA Fax +1(412)6249861.
Curran
Dennis P
DP