Receptor activity modifying proteins and their potential as drug targets.
The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.
Wootten
Denise L
DL
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Simms
John
J
Hay
Debbie L
DL
Christopoulos
Arthur
A
Sexton
Patrick M
PM
D000595:Amino Acid Sequence; D000818:Animals; D055808:Drug Discovery; D006031:Glycosylation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes; D058261:Receptor Activity-Modifying Proteins; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D058261:Receptor Activity-Modifying Proteins; D043562:Receptors, G-Protein-Coupled