Synthesis, crystal structure, antioxidant activity, and DNA-binding studies of a novel Ni(II) [2x2] grid complex with a rigid bistridentate Schiff base ligand.
With a bistridentate Schiff-base ligand, N',N'(3)-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H(2)L), a [2x2]G grid complex, [Ni(4)(HL)(4)](ClO(4))(4).4H(2)O.0.5 CH(3)OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound 1 strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(II) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.
Jia
Lei
L
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P.R. China.
Xu
Jun
J
Xu
Xi-Ming
XM
Chen
Long-Hai
LH
Jiang
Peng
P
Cheng
Fei-Xiang
FX
Lu
Guang-Nong
GN
Wang
Qin
Q
Wu
Jin-Cai
JC
Tang
Ning
N
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
D000975:Antioxidants; D016166:Free Radical Scavengers; D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D013481:Superoxides; D017665:Hydroxyl Radical; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA