title: Collision tumor of primary laryngeal mucosal melanoma and invasive squamous cell carcinoma with IL-17A and CD70 gene over-expression.
abstract: The most common primary malignancy of the larynx is the squamous cell carcinoma (SCC). The primary malignant melanoma is quite rare in this location. Less than 60 cases of laryngeal melanomas have been reported to date. To our knowledge, collision primary malignant melanoma and invasive squamous cell carcinoma in the vocal cords has not been reported. We report a 53-year-old male patient who was diagnosed with a collision tumor of laryngeal melanoma and invasive SCC. Multiple Th17 pathway related genes including CTLA-4, IL-17A-F, PLZF, FoxP3, RorγT, CD27, and CD70 were analyzed by reverse transcriptase-polymerase chain reaction (Rt-PCR) in this case. Both IL-17A and CD70 genes were detected in this case of collision tumor. The results may define useful biomarkers for early diagnosis of mucosal melanoma and open an immunotherapeutic field for clinical management with the potential benefit from the immunomodulators that enhance both genes.
authors.affiliation: Department of Pathology, New York University School of Medicine, 550 First Avenue, TCH-461, New York, NY 10016, USA.
authors.forename: Sasis
authors.initials: S
authors.lastname: Sirikanjanapong
authors.forename: Biana
authors.initials: B
authors.lastname: Lanson
authors.forename: Milan
authors.initials: M
authors.lastname: Amin
authors.forename: Frank
authors.initials: F
authors.lastname: Martiniuk
authors.forename: Hideko
authors.initials: H
authors.lastname: Kamino
authors.forename: Beverly Y
authors.initials: BY
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D053282:CD27 Ligand / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014827:Vocal Cords / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D053282:CD27 Ligand; C505771:CD70 protein, human; C508717:IL17A protein, human; D020381:Interleukin-17