title: Inducing chromosome pairing through premature condensation: analysis of wheat interspecific hybrids.
abstract: At the onset of meiosis, chromosomes first decondense and then condense as the process of recognition and intimate pairing occurs between homologous chromosomes. We show here that okadaic acid, a drug known to induce chromosome condensation, can be introduced into wheat interspecific hybrids prior to meiosis to induce chromosome pairing. This pairing occurs in the presence of the Ph1 locus, which usually suppresses pairing of related chromosomes and which we show here delays condensation. Thus the timing of chromosome condensation during the onset of meiosis is an important factor in controlling chromosome pairing.
authors.affiliation: John Innes Centre, Colney, Norwich NR4 7UH, UK.
authors.forename: Emilie
authors.initials: E
authors.lastname: Knight
authors.forename: Emma
authors.initials: E
authors.lastname: Greer
authors.forename: Tracie
authors.initials: T
authors.lastname: Draeger
authors.forename: Vera
authors.initials: V
authors.lastname: Thole
authors.forename: Steve
authors.initials: S
authors.lastname: Reader
authors.forename: Peter
authors.initials: P
authors.lastname: Shaw
authors.forename: Graham
authors.initials: G
authors.lastname: Moore
mesh_terms: D002678:Chimera / Q000235:genetics*; D023902:Chromosome Pairing; D032461:Chromosomes, Plant / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008540:Meiosis; D019319:Okadaic Acid / Q000494:pharmacology; D016376:Oligonucleotides, Antisense / Q000378:metabolism; D014908:Triticum / Q000235:genetics*
chemical_list: D004791:Enzyme Inhibitors; D016376:Oligonucleotides, Antisense; D019319:Okadaic Acid