Vitamin A supplementation to pregnant and breastfeeding female rats induces oxidative stress in the neonatal lung.
Vitamin A is an essential micronutrient that regulates many biological processes through modulation of retinoic acid receptor-responsive genes. Vitamin A acts as a systemic antioxidant, participating in the modulation of diverse redox mechanisms involved in physiological and pathological processes. Different studies, however, observed that vitamin A and other retinoids may induce pro-oxidant/deleterious actions under certain conditions, leading to impairment of brain and lung function. Here, we studied the effect of vitamin A treatment at oral doses of 100 IU/kg, 200 IU/kg, and 300 IU/kg to female rats (Rattus norvegicus) during pregnancy and lactation on oxidative parameters of lungs from the offspring vitamin A supplementation induced increases in lipoperoxidation, protein carbonyl, activities of the antioxidant enzymes superoxide dismutase and catalase (200 IU/kg, and 300 IU/kg), and decreased sulphydryl protein (500 IU/kg) content in the neonatal lung.
Pasquali
Matheus Augusto de Bittencourt
MA
Universidade Federal do Rio Grande do Sul - UFRGS, CEEO - Centro de Estudos de Estresse Oxidativo, Brazil. 00124262@ufrgs.br
Schnorr
Carlos Eduardo
CE
Feistauer
Lucas Brambilla Hilbig
LB
Gelain
Daniel Pens
DP
Moreira
José Cláudio Fonseca
JC
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D005260:Female; D007774:Lactation / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D000084562:Retinyl Esters; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics
D000975:Antioxidants; D004224:Diterpenes; D000084562:Retinyl Esters; D013438:Sulfhydryl Compounds; D014815:Vitamins; D014801:Vitamin A; C014794:retinol palmitate; D002374:Catalase; D013482:Superoxide Dismutase