Soluble receptor of advanced glycation end products levels are related to ischaemic aetiology and extent of coronary disease in chronic heart failure patients, independent of advanced glycation end products levels: New Roles for Soluble RAGE.
OBJECTIVE
Knowledge of the role of advanced glycation end products (AGE), their receptor (RAGE), and the receptor's soluble form (sRAGE), in heart failure (HF) is very limited. We evaluated the clinical role of the AGE-RAGE system in HF and in particular any association it might have with ischaemic aetiology.


RESULTS
We measured fluorescent AGE, glycated albumin and sRAGE in 103 patients with chronic HF. We showed that sRAGE but not AGE was related to ischaemic aetiology (1638.3 ± 207.4 ischaemic vs. 1065.1 ± 94.2 pg/mL non-ischaemic group; P =0.016) independent of age, sex, diabetes, renal function, clinical severity, or other variables (OR: 1.091; 95% CI (confidence interval): 1.032-1.153; P =0.007). Moreover, sRAGE was directly associated with extent of coronary disease (OR for three vessel disease compared with non-coronary lesions: 1.186; 95% CI: 1.065-1.322; P =0.002). We also found a correlation between sRAGE and severity of HF, which increased with New York Heart Association (NYHA) class (741.9 ± 88.9 pg/mL in class 1, 1195.9 ± 113.2 pg/mL in class II, and 1724.8 ± 245.7 pg/mL in class III (P < 0.05)) and brain natriuretic peptide (BNP) levels (667.4 ± 68.0 vs. 1344.5 ± 126.0 pg/mL for BNP < and ≥400 pg/mL, respectively).


CONCLUSIONS
sRAGE is an indicator of chronic heart failure severity and an independent marker of coronary artery disease and its severity in patients with CHF.
Raposeiras-Roubín
Sergio
S
Cardiology Department and Coronary Unit, Clinical Hospital of Santiago de Compostela, Santiago, Spain.
Rodiño-Janeiro
Bruno K
BK
Grigorian-Shamagian
Lilian
L
Moure-González
María
M
Seoane-Blanco
Ana
A
Varela-Román
Alfonso
A
Alvarez
Ezequiel
E
González-Juanatey
José R
JR
D000368:Aged; D000418:Albumins; D002908:Chronic Disease; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005919:Glomerular Filtration Rate; D017127:Glycation End Products, Advanced / Q000097:blood*; D006333:Heart Failure / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012372:ROC Curve; D012720:Severity of Illness Index; D013223:Statistics as Topic
D000418:Albumins; D017127:Glycation End Products, Advanced