title: The new polyomavirus (MCPyV) does not affect the clinical course in MCCs.
abstract: Since 2008, a new polyomavirus (MCPyV) in Merkel cell carcinomas (MCC) has been described, but little is known about its impact on the clinical course. The purpose of this study was to determine the presence of MCPyV in a large sample and to correlate the results with the clinical course of the disease. 59 samples from 44 patients were analysed for the presence of MCPyV using the primers LT3, VP1 and LT1. The clinical records of these patients were evaluated and correlated with the presence of MCPyV. 58% of specimens were positive for MCPyV. Of these, LT3 was positive in 53%, VP1 in 37% and LT1 in 10%. 57% of primary tumours and 53% of metastases were positive for LT3; the numbers for VP1 and LT1 were lower. There was no correlation between the detection of MCPyV in the primary tumour and the appearance of metastases. The survival time was statistically independent from the presence of MCPyV. There is a striking occurrence of MCPyV in MCC, but whether it affects the clinical course remains unclear.
authors.affiliation: Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-University, Düsseldorf, Germany. handschel@med.uni-duesseldorf.de
authors.forename: J
authors.initials: J
authors.lastname: Handschel
authors.forename: D
authors.initials: D
authors.lastname: Müller
authors.forename: R A
authors.initials: RA
authors.lastname: Depprich
authors.forename: M A
authors.initials: MA
authors.lastname: Ommerborn
authors.forename: N R
authors.initials: NR
authors.lastname: Kübler
authors.forename: C
authors.initials: C
authors.lastname: Naujoks
authors.forename: J
authors.initials: J
authors.lastname: Reifenberger
authors.forename: K-L
authors.initials: KL
authors.lastname: Schäfer
authors.forename: S
authors.initials: S
authors.lastname: Braunstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000401:mortality / Q000473:pathology / Q000821:virology*; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D011120:Polyomavirus / Q000302:isolation & purification* / Q000472:pathogenicity; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000821:virology*; D016019:Survival Analysis
chemical_list: D004279:DNA, Viral