title: Comparison of ondansetron and metoclopramide antiemetic prophylaxis in maxillofacial surgery patients.
abstract: OBJECTIVE
  The purpose of this study was to compare the efficacy of ondansetron and metoclopramide, administered for the prophylaxis of vomiting in patients undergoing oral and maxillofacial surgery under general anesthesia.
  
  
  METHODS
  One hundred patients undergoing mandibular osteotomy surgery were studied. Patients were allocated randomly to receive 1 of 2 treatment regimens: 0.15 mg/kg ondansetron or 0.5 mg/kg metoclopramide intravenously 30 minutes before extubation. All were adults and were treated by one surgeon and all operations were the same and lasted 2.5 to 3.0 hours. The patients were assessed at 3 time periods: 0 to 3 hours, 3 to 12 hours, and 12 to 24 hours postoperatively for emesis.
  
  
  RESULTS
  The data from this study showed that during the first 24-hour postoperative period, patients receiving ondansetron following general anesthesia had an 11% (11 patients) incidence of emesis compared with 28% (22 patients) in the group that received metoclopramide.
  
  
  CONCLUSIONS
  In this study, ondansetron (0.1 mg/kg) was twice as effective in preventing postoperative vomiting compared with metoclopramide.
authors.affiliation: Tabriz Medical Sciences University (TMSU), Tabriz, Iran.
authors.forename: Koroush Taheri
authors.initials: KT
authors.lastname: Talesh
authors.forename: Mohammad Hosein Kalantar
authors.initials: MH
authors.lastname: Motamedi
authors.forename: Shiva
authors.initials: S
authors.lastname: Kahnamouii
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008334:Mandible / Q000601:surgery*; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D017294:Ondansetron / Q000008:administration & dosage / Q000627:therapeutic use*; D010027:Osteotomy; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control; D011292:Premedication; D012121:Respiration, Artificial; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D017294:Ondansetron; D008787:Metoclopramide