Osteoporosis as a potential contributor to the bone metastases.
Bone metastasis is a serious complication of patients with tumor, and most primary tumors can metastasize to bone. And the main threat and the reason for most cancer deaths are not the primary neoplasias, but secondary tumors, the metastases. To minimize the morbidity and economic expenditure associated with bone metastases, it is important to decrease the etiological factors of bone metastasis. Although current evidence suggested that the therapies to the underlying malignancy bone metastasis might result in bone loss leading to osteoporosis, no studies have shown direct evidence the successful seeding of bone metastases of cancer cells is the part played by osteoporosis. In the state of osteoporosis, for the enhancement of the osteolysis, the increased inflammatory factors could make blood vessels leakier, resulting in the easier hematogenous metastasis to bone and bone marrow. Moreover, leptin, which was positive correlation with osteoporosis, has been showed to exert angiogenic effects and could regulate VEGF expression, promoting the proliferation of the cancer blood vessel. In addition, the increased growth factors in osteoporosis could enrich the local microenvironment, promoting the growth of the metastasis mass. Given the above background, we hypothesize that osteoporosis may be a potential contributor to the bone metastases.
Wu
Yong-Ping
YP
Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou 310009, China. zrorthopaedics@gmail.com
Chen
Wei-Shan
WS
Xu
Sheng-Jie
SJ
Zhang
Ning
N
D001859:Bone Neoplasms / Q000098:blood supply / Q000556:secondary*; D006801:Humans; D020738:Leptin / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D010024:Osteoporosis / Q000150:complications*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020738:Leptin; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A