Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
The fork-head transcription factors are involved in a variety of physiological processes including development, aging, obesity, and cancer. The fork-head transcription factor FOXN3 has been implicated in cell cycle and transcription regulation at the cellular level. However, the physiological functions of FOXN3 in mammals are not known. To understand the role of the fork-head transcription factor FOXN3 in mammalian development, we have generated a mutant mouse model for the Foxn3 gene. Our analysis shows that the Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects. Foxn3 mutant tissues and cells are also defective in the expression of distinct osteogenic genes. Interestingly, the phenotypes of Foxn3 mutant mice show a striking overlap with the clinical features of human patients with congenital defects and chromosomal aberrations involving the human FOXN3 locus. More than three fourths of human congenital disorders involve craniofacial malformations and a majority of the perturbed genetic components that lead to such disorders are yet to be identified. Our results implicate a role for the FOXN3 gene in the etiology of craniofacial defects in humans.
Samaan
George
G
Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
Yugo
Danielle
D
Rajagopalan
Sangeetha
S
Wall
Jonathan
J
Donnell
Robert
R
Goldowitz
Dan
D
Gopalakrishnan
Rajaram
R
Venkatachalam
Sundaresan
S
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics*; D019465:Craniofacial Abnormalities / Q000235:genetics*; D020964:Embryo Loss / Q000235:genetics*; D005124:Eye Abnormalities / Q000235:genetics; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D005804:Genes, Lethal; D006130:Growth Disorders / Q000235:genetics; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics*; D014071:Tooth Abnormalities / Q000235:genetics
D018797:Cell Cycle Proteins; C106158:FOXN3 protein, human; D051858:Forkhead Transcription Factors; C552694:Foxn3 protein, mouse; D012097:Repressor Proteins