title: [Significance of platelet function tests].
abstract: Numerous laboratory tests are in use to detect congenital or acquired platelet function disorders. Platelet aggregometry, using ADP, collagen, arachidonic acid or ristocetin as inductor is the standard test system for diagnosis. It is also used to detect platelet non-response to antiplatelet therapy. Studies have demonstrated that laboratory assessment of platelet non response to aspirin or clopidogrel is associated with adverse outcomes, and they indicate the importance of adjusting antiplatelet therapy in patients with a low degree of platelet inhibition. Nevertheless, a standardized method for identifying these patients is still missing.
authors.affiliation: Medizinische Klinik III, Schwerpunkt Angiologie und Hämostaseologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland. Zsuzsanna.Wolf@kgu.de
authors.forename: Z
authors.initials: Z
authors.lastname: Wolf
authors.forename: H
authors.initials: H
authors.lastname: Mani
authors.forename: E
authors.initials: E
authors.lastname: Lindhoff-Last
mesh_terms: D000244:Adenosine Diphosphate; D016718:Arachidonic Acid; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D001791:Blood Platelet Disorders / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D000077144:Clopidogrel; D003094:Collagen; D006474:Hemorrhagic Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D010979:Platelet Function Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D012310:Ristocetin; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D012310:Ristocetin; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin