title: [The effect of atrial pacing on left ventricular diastolic function and BNP levels in patients with DDD pacemaker].
abstract: OBJECTIVE
  We aimed to investigate the effect of atrial pacing on left ventricular diastolic function and brain natriuretic peptide (BNP) levels in patients with DDD pacemaker.
  
  
  METHODS
  Thirty patients with complete atrio-ventricular (AV) block and DDD pacemaker were included. All patients had normal left ventricular systolic function. Echocardiographic diastolic function parameters (transmitral and tissue Doppler velocities during early (E and E') and late (A and A') filling) and NT-pro-BNP levels were evaluated prospectively during atrial sensing and pacing periods. Echocardiographic data were compared with paired sample t test and NT-pro-BNP levels were compared with Wilcoxon test.
  
  
  RESULTS
  Echocardiographic E/A, E'/A', E/E' ratios were calculated as 0.72+/-0.34, 0.61+/-0.21 and 8.76+/-2.58 during atrial sensing period. Same parameters were found as 0.71+/-0.23, 0.64+/-0.16 and 8.93+/-3.16 respectively during atrial pacing period. Echocardiographic left ventricular diastolic function parameters were not significantly different during atrial pacing and atrial sensing periods. Median plasma NT-pro-BNP levels were measured as 142 pg/ml (min-max 47-563 pg/ml) and 147 pg/ml (min-max 33-1035 pg/ml) during atrial sensing and pacing periods respectively. These levels were not significantly different (p=0.86).
  
  
  CONCLUSIONS
  The result of this study has shown that, atrial pacing has not any additional detrimental effect on left ventricular diastolic function parameters in paced patients with normal left ventricular systolic function.
authors.affiliation: Atatürk Eğitim Hastanesi, 1. Kardiyoloji Kliniği, Izmir, Türkiye.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Apali
authors.forename: Serdar
authors.initials: S
authors.lastname: Bayata
authors.forename: Murat
authors.initials: M
authors.lastname: Yeşil
authors.forename: Erdinç
authors.initials: E
authors.lastname: Arikan
authors.forename: Nursen
authors.initials: N
authors.lastname: Postaci
mesh_terms: D054537:Atrioventricular Block / Q000628:therapy*; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D004867:Equipment Design; D006325:Heart Atria / Q000000981:diagnostic imaging; D006801:Humans; D010138:Pacemaker, Artificial; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000628:therapy*