title: Highly enantioselective hydrogenative desymmetrization of bicyclic imides leading to multiply functionalized chiral cyclic compounds.
abstract: Highly enantioselective hydrogenative desymmetrization of bicyclic imides has been developed with chiral Cp*Ru(PN) catalysts. The present hydrogenation directly provides stereochemically well-defined cyclic compounds with excellent enantiomeric exessses, which might otherwise require a detour to reach.
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Ito
authors.forename: Chika
authors.initials: C
authors.lastname: Kobayashi
authors.forename: Akio
authors.initials: A
authors.lastname: Himizu
authors.forename: Takao
authors.initials: T
authors.lastname: Ikariya
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007094:Imides