title: Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation.
abstract: OBJECTIVE
  The objective of the study was to measure the volumetric bone mineral density (vBMD) using diagnostic computed tomography scans in gynecologic oncology patients.
  
  
  METHODS
  In a retrospective study, spine and femoral neck (FN) vBMD was measured for 1 year in 40 patients receiving chemotherapy or radiation.
  
  
  RESULTS
  There is significant bone loss after chemotherapy, radiation, and a combination of radiation and chemotherapy (P = .0211). In 1 year, the percent reduction in vBMD (±SE) at L1-L2 spine and the FN was a 15.9% (±5.67) and 10.4% (±4.06) in chemotherapy; 11% (±5.68) and 15.8% (±2.56) in radiation; and 21.0% (±7.03) and 3.6% (±3.3.7) in the combined therapy group. Bone loss was evident immediately after treatment and persisted or worsened in most women.
  
  
  CONCLUSIONS
  Gynecologic cancer patients treated with chemotherapy or radiation experience immediate and prolonged bone loss; thus, pre- and posttreatment monitoring of bone loss is important in these patients.
authors.affiliation: Department of Therapeutic Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA. huixx019@umn.edu
authors.forename: Susanta K
authors.initials: SK
authors.lastname: Hui
authors.forename: Ali
authors.initials: A
authors.lastname: Khalil
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kathleen
authors.initials: K
authors.lastname: Coghill
authors.forename: Chap
authors.initials: C
authors.lastname: Le
authors.forename: Kathryn
authors.initials: K
authors.lastname: Dusenbery
authors.forename: Jerry
authors.initials: J
authors.lastname: Froelich
authors.forename: Douglas
authors.initials: D
authors.lastname: Yee
authors.forename: Levi
authors.initials: L
authors.lastname: Downs
mesh_terms: D015519:Bone Density; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging*; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010865:Pilot Projects; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed