title: Undiagnosed collecting duct carcinoma presenting as meningeal carcinomatosis and multiple bone metastases.
abstract: A 54-year-old woman presented with blepharoptosis, numbness in the lower lip, dysgeusia and pain in the extremities and back. MRI showed marked meningeal thickening and multiple bone lesions accompanying a prominent enhancing effect. CT scan of the chest and abdomen appeared to be unremarkable for primary cancer. She died 3 months after the admission, and postmortem autopsy showed a mass of about 2.5 cm in diameter in the renal medulla. Histological examination including immunohistochemistry confirmed the presence of a collecting duct carcinoma (CDC). This case is of particular interest because it emphasizes the possible fulminate clinical course of a small CDC.
authors.affiliation: Department of Internal Medicine, Kushiro Rosai Hospital, Kushiro. shunpou@hotmail.com
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ohnishi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Dazai
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Tsuzaka
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Takuto
authors.initials: T
authors.lastname: Miyagishima
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D055756:Meningeal Carcinomatosis / Q000175:diagnosis*; D008875:Middle Aged