Palhinine A, a novel alkaloid from Palhinhaea cernua.
Palhinine A, a novel C(16)N-type Lycopodium alkaloid with a unique 5/6/6/9 tetracyclic ring system, was isolated from the whole plant of Palhinhaea cernua L. (Lycopodiaceae). Its structure was elucidated by spectroscopic methods, and the absolute configuration was determined by single-crystal X-ray diffraction analysis using the Flack parameter. Palhinine A is reported as the first example of Lycopodium alkaloids of which C-16 is fused to a new ring through a C-16-C-4 lingkage.
Zhao
Fu-Wei
FW
Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Sun
Qian-Yun
QY
Yang
Fu-Mei
FM
Hu
Guang-Wan
GW
Luo
Ji-Feng
JF
Tang
Gui-Hua
GH
Wang
Yue-Hu
YH
Long
Chun-Lin
CL
D000110:Acetylcholinesterase / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D032502:Lycopodium / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C553649:palhinine A; D000110:Acetylcholinesterase