title: Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity.
abstract: New oxathiazinane dioxides have been derived from D- and L-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC(50) approximately 10 microM.
authors.affiliation: Laboratory of Glycochemistry and Asymmetric Synthesis, Swiss Institute of Technology (EPFL), Lausanne, Switzerland.
authors.forename: Françoise
authors.initials: F
authors.lastname: Borcard
authors.forename: Matthias
authors.initials: M
authors.lastname: Baud
authors.forename: Claudia
authors.initials: C
authors.lastname: Bello
authors.forename: Giovanna
authors.initials: G
authors.lastname: Dal Bello
authors.forename: Francesco
authors.initials: F
authors.lastname: Grossi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pronzato
authors.forename: Michele
authors.initials: M
authors.lastname: Cea
authors.forename: Alessio
authors.initials: A
authors.lastname: Nencioni
authors.forename: Pierre
authors.initials: P
authors.lastname: Vogel
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013843:Thiazines