title: Direct synthesis of 6-arylpurines by reaction of 6-chloropurines with activated aromatics.
abstract: Highly functionalized C6-aryl-substituted purine analogues were synthesized through direct arylation of 6-chloropurine with aromatics promoted by anhydrous AlCl(3) in a single step. The reactions, which were conducted using a 3-fold excess of AlCl(3) in refluxing 1,2-dichloroethane, gave moderate to excellent product yields in 0.5 h. This work is complementary to the classical coupling reactions for the synthesis of C6-aryl-substituted purine analogues.
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China. ghm@htu.cn
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Pu
authors.initials: P
authors.lastname: Li
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Dong-Chao
authors.initials: DC
authors.lastname: Wang
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D006841:Hydrocarbons, Aromatic; D011687:Purines; D000077410:Aluminum Chloride; C079308:6-chloropurine