Cirrhotic cardiomyopathy.
Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by an abnormal and blunted response to physiologic, pathologic, or pharmacologic stress but normal to increased cardiac output and contractility at rest. As many as 50% of cirrhotic patients undergoing liver transplantation show signs of cardiac dysfunction, and 7% to 21% of deaths after orthotopic liver transplantation result from overt heart failure. In this review, we critically evaluate the existing literature on the pathophysiology and clinical implications of cirrhotic cardiomyopathy.
Zardi
Enrico M
EM
Department of Clinical Medicine, University Campus Bio-Medico, Via Alvaro del Portillo, Rome, Italy. e.zardi@unicampus.it
Abbate
Antonio
A
Zardi
Domenico Maria
DM
Dobrina
Aldo
A
Margiotta
Domenico
D
Van Tassell
Benjamin W
BW
Van Tassel
Benjamin W
BW
Afeltra
Antonella
A
Sanyal
Arun J
AJ
D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology*; D005355:Fibrosis; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology*