[3-azabicyclo[3.1.0]hex-1-yl]phenyl-benzenesulfonamides as selective dopamine D3 antagonists.
A new class of azabicyclo[3.1.0]benzenesulfonamides is presented as selective dopamine D3 antagonists together with SAR and selectivity data.
Micheli
Fabrizio
F
Neurosciences Centre of Excellence, GlaxoSmithKline Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy. fabrizio.micheli@aptuit.com
Hamprecht
Dieter
D
Bonanomi
Giorgio
G
Di Fabio
Romano
R
Donati
Daniele
D
Gentile
Gabriella
G
Heidbreder
Christian
C
Prandi
Adolfo
A
Tarsi
Luca
L
Terreni
Silvia
S
D001554:Benzene / Q000737:chemistry / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
D018492:Dopamine Antagonists; D050637:Receptors, Dopamine D3; D013449:Sulfonamides; D001554:Benzene