title: HBCD stereoisomer pattern in mirror carps following dietary exposure to pure gamma-HBCD enantiomers.
abstract: 1,2,5,6,9,10-hexabromocyclododecane (HBCD) is a brominated flame retardant consisting of a mixture of diastereomeric pairs of enantiomers that is a known omnipresent, environmental contaminant. The present study investigated the possibility of bioisomerization of HBCD stereoisomers. Therefore, mirror carps (Cyprinus carpio morpha noblis) were exposed to pure (+)- and (-)-gamma-HBCD, randomly sampled biweekly over a period of three and a half months and the fillets were subjected to enantiomer-specific determination of HBCD. Considering the background contamination of the fish at the beginning of the feeding period, significant enrichment of the respectively fed gamma-enantiomer was already detectable after two weeks of exposure. However, no significant enrichment of the respectively expected alpha-enantiomer was observed within this period. Thus, no evidence for the isomerization of HBCD stereoisomers was found in mirror carp under the applied conditions.
authors.affiliation: BAM Federal Institute for Materials Research and Testing, Richard-Willstatter-Strasse 11, 12489 Berlin, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Esslinger
authors.forename: Roland
authors.initials: R
authors.lastname: Becker
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller-Belecke
authors.forename: Wolfram
authors.initials: W
authors.lastname: Bremser
authors.forename: Christian
authors.initials: C
authors.lastname: Jung
authors.forename: Irene
authors.initials: I
authors.lastname: Nehls
mesh_terms: D000818:Animals; D002347:Carps; D006842:Hydrocarbons, Brominated / Q000737:chemistry* / Q000633:toxicity; D013237:Stereoisomerism
chemical_list: D006842:Hydrocarbons, Brominated; C089796:hexabromocyclododecane