Tetrathiafulvalene end-functionalized poly(N-isopropylacrylamide): a new class of amphiphilic polymer for the creation of multistimuli responsive micelles.
In this article, we report the formation of micelles from a tetrathiafulvalene (TTF) end-functionalized poly(N-isopropylacrylamide) (poly(NIPAM)) derivative (1). We have determined the critical aggregation concentration (CAC) and average diameter of the micelles using fluorescence spectroscopy and dynamic light scattering experiments, respectively. We have exploited the NIPAM backbone of the polymer to thermally transform the swollen hydrophilic poly(NIPAM) derivative to a more globular hydrophobic state at the lower critical solution temperature (LCST). Finally, we have shown that we can exploit the chemical oxidation and complexation properties of the TTF unit to disrupt the micelle architecture to release the hydrophobic dye Nile Red from the interior of the micelle.
Bigot
Julien
J
Univ Lille Nord de France, F-59000 Lille, France USTL, Unité des Matériaux Et Transformations (UMET, UMR 8207), Team Ingénierie des Systèmes Polymères, 59650 Villeneuve d'Ascq Cedex, France.
Charleux
Bernadette
B
Cooke
Graeme
G
Delattre
François
F
Fournier
David
D
Lyskawa
Joël
J
Sambe
Léna
L
Stoffelbach
François
F
Woisel
Patrice
P
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D005456:Fluorescent Dyes / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry; D010084:Oxidation-Reduction; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013499:Surface Properties; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D005456:Fluorescent Dyes; D006571:Heterocyclic Compounds; D008823:Micelles; D010078:Oxazines; D011108:Polymers; C052970:poly-N-isopropylacrylamide; C063887:tetrathiafulvalene; C044808:nile red