title: Anti-HCV reactive volunteer blood donors distribution character and genotypes switch in Xi'an, China.
abstract: HCV is prevailed in the world as well as in China. Blood transfusion is one of the most common transmission pathways of this pathogen. Although data of HCV infection character were reported during the past years, anti-HCV reactive profile of China donors was not fully clear yet. Furthermore, infection progress was found related to the HCV genotype. Different genotype led to different efficacy when interferon was introduced into HCV therapy. Here we provided character data of HCV infection in China blood donors from the year of 2000 to 2009. The infection rate in local donors was lower than general population and descended from 0.80% to 0.40% or so in recent years. About 83% HCV strains were categorized into genotypes 1b and 2a. But 1b subtype cases climbed and 2a subtype cases decreased. The current study threw more light on HCV infection of blood donors in China, at least in the Northern region.
authors.affiliation: Department of Clinic Molecular Research Center& Clinic Diagnostic Laboratory, Xijing Hospital, Fourth Military Medical University, 17th Changlexi Road, Xi'an 710032, China.
authors.forename: Qiao-hong
authors.initials: QH
authors.lastname: Yue
authors.forename: Xian-qing
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Shang
authors.forename: Yao-zhen
authors.initials: YZ
authors.lastname: Chen
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Sun
authors.forename: Min-quan
authors.initials: MQ
authors.lastname: Su
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Mu
authors.forename: Xiao-ke
authors.initials: XK
authors.lastname: Hao
authors.forename: Xing-bin
authors.initials: XB
authors.lastname: Hu
mesh_terms: D001782:Blood Donors; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification*; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016036:Seroepidemiologic Studies
chemical_list: D018937:Hepatitis C Antibodies