Macrophage migration inhibitory factor plays a pivotal role in hepatocellular carcinoma and may be a noninvasive imaging target.
Macrophage migration inhibitory factor (MIF) has emerged to play a central role in the control of the host inflammatory and immune response. Several reports have documented that MIF can inactivate the tumor suppresser activity of p53; overexpression of MIF was significantly higher in both the sera and the local lesions from patients with HCC than from patients with normal controls. These findings indicate that MIF may contribute to multiple aspects of tumor progression and neoplasia, thus MIF may be an effective therapeutic target molecule. We speculate that MIF is important for the development and progression of hepatocellular carcinoma, and can be used as a marker for tumor detection.
Han
Yeming
Y
Shandong University School of Medicine, Key Laboratory for Experimental Teratology, Ministry of Education and Institute of Experimental Nuclear Medicine, Wenhuaxi road 44 Jinan, Shandong, China.
Zhang
Chao
C
D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood / Q000378:metabolism*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood / Q000378:metabolism*
D014408:Biomarkers, Tumor; D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human