RIG-I "sees" the 5'-triphosphate.
RIG-I protects host cells against various RNA viruses by sensing viral RNAs in the cytoplasm. Crystal structures of RIG-I C-terminal domain bound to 5'-triphosphate dsRNA unveils how RIG-I recognizes the 5'-triphosphate moiety, a hallmark of viral RNAs (Lu et al., 2010).
Zheng
Chao
C
Weill Medical College of Cornell University, New York, NY 10021, USA.
Wu
Hao
H