C-reactive protein is a bystander of cardiovascular disease.
A large number of studies have evaluated the association of hs-C-reactive protein with atherosclerosis and coronary heart disease (CHD) in mechanistic, genetic, population-based studies, as well as clinical trials. This paper reviews the collective evidence to determine if hs-C-reactive protein is part of the causal pathway of atherosclerosis and CHD or whether it is a bystander.
Anand
Sonia S
SS
Population Health Research Institute, McMaster University, Hamilton General Hospital Campus, DB-CVSRI, 237 Barton Street East, Rm. C3102 Hamilton, Ontario, Canada L8L 2X2. anand@hhsc.ca
Yusuf
Salim
S
D050197:Atherosclerosis / Q000209:etiology*; D002097:C-Reactive Protein / Q000502:physiology*; D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic
D002097:C-Reactive Protein