The role of porphyrin chemistry in tumor imaging and photodynamic therapy.
In recent years several review articles and books have been published on the use of porphyrin-based compounds in photodynamic therapy (PDT). This critical review is focused on (i) the basic concept of PDT, (ii) advantages of long-wavelength absorbing photosensitizers (PS), (iii) a brief discussion on recent advances in developing PDT agents, and (iv) the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo, for developing highly effective long-wavelength PDT agents and their utility in constructing the conjugates with tumor-imaging and therapeutic potential (Theranostics). The clinical status of certain selected PDT agents is also summarized (205 references).
Ethirajan
Manivannan
M
PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Chen
Yihui
Y
Joshi
Penny
P
Pandey
Ravindra K
RK
D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry* / Q000627:therapeutic use
D017319:Photosensitizing Agents; D011166:Porphyrins; D002734:Chlorophyll; C083998:2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a