title: Preparation of (90)YCl(3) radiopharmaceutical precursor for nuclear medicine using technology of centrifugal extractors.
abstract: Separation of (90)Y from a parent solution of (90)Sr-(90)Y in 0.5 M nitric acid by two-stage liquid-liquid extraction has been investigated using centrifugal extractors. The extraction agent used was 0.25 M di-(2-ethylhexyl)phosphoric acid (D2EHPA) in n-dodecane. Back-extraction used 5 M HCl. Evaporation of HCl was performed in a rotary vacuum evaporator. Experience gained during the design, construction and running of more than 100 hot separations is presented. A short description of analytical methods used and results of the determination of chemical, radionuclidic and radiochemical purities and sterility are given.
authors.affiliation: Nuclear Physics Institute of the ASCR, Public Research Institution, Radiopharmaceutical Department, 250 68 Rez near Prague, Czech Republic. srj@ujf.cas.cz
authors.forename: J
authors.initials: J
authors.lastname: Srank
authors.forename: F
authors.initials: F
authors.lastname: Melichar
authors.forename: A T
authors.initials: AT
authors.lastname: Filyanin
authors.forename: M
authors.initials: M
authors.lastname: Tomes
authors.forename: M
authors.initials: M
authors.lastname: Beran
mesh_terms: D002498:Centrifugation; D009683:Nuclear Medicine; D019275:Radiopharmaceuticals / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; C064782:yttrium chloride; D015019:Yttrium