title: Stimulation of the globus pallidus internus in a patient with DYT1-positive primary generalized dystonia: a 10-year follow-up.
abstract: The authors report the case of DYT1-positive primary generalized dystonia refractory to medical management that was successfully treated with continuous deep brain stimulation of the internal segment of the globus pallidus. Prior studies have shown that neuromusculoskeletal deficits can remain permanent if early surgical intervention is not undertaken. The authors report prolonged efficacy and safety over a 10-year period in a 28-year-old man.
authors.affiliation: Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.
authors.forename: Dunbar
authors.initials: D
authors.lastname: Alcindor
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Oh
authors.forename: Susan
authors.initials: S
authors.lastname: Baser
authors.forename: Cindy
authors.initials: C
authors.lastname: Angle
authors.forename: Boyle C
authors.initials: BC
authors.lastname: Cheng
authors.forename: Donald
authors.initials: D
authors.lastname: Whiting
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D004422:Dystonia Musculorum Deformans / Q000235:genetics* / Q000628:therapy*; D020821:Dystonic Disorders / Q000628:therapy; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human