title: Synthesis, crystal structure, antioxidant activity, and DNA-binding studies of a novel Ni(II) [2x2] grid complex with a rigid bistridentate Schiff base ligand.
abstract: With a bistridentate Schiff-base ligand, N',N'(3)-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H(2)L), a [2x2]G grid complex, [Ni(4)(HL)(4)](ClO(4))(4).4H(2)O.0.5 CH(3)OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound 1 strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(II) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.
authors.affiliation: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jia
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Xi-Ming
authors.initials: XM
authors.lastname: Xu
authors.forename: Long-Hai
authors.initials: LH
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
authors.forename: Fei-Xiang
authors.initials: FX
authors.lastname: Cheng
authors.forename: Guang-Nong
authors.initials: GN
authors.lastname: Lu
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Jin-Cai
authors.initials: JC
authors.lastname: Wu
authors.forename: Ning
authors.initials: N
authors.lastname: Tang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D013481:Superoxides; D017665:Hydroxyl Radical; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA