title: Prospective hospital-based surveillance to estimate rotavirus disease burden in the Gauteng and North West Province of South Africa during 2003-2005.
abstract: BACKGROUND
  Rotavirus is considered to be the most common cause of serious acute dehydrating diarrhea worldwide. However, there is a scarcity of information on rotavirus disease burden in sub-Saharan Africa.
  
  
  METHODS
  We conducted prospective, hospital-based surveillance for rotavirus diarrhea among children <5 years of age at the tertiary care Dr. George Mukhari Hospital (DGM) and at the Brits district Hospital (BH) in the Gauteng and North West Provinces in South Africa; we estimated that up to 80% of children <5 years of age in their catchment areas who are hospitalized for diarrhea are admitted to one of these hospitals.
  
  
  RESULTS
  At DGM, 2553 children <5 years of age were admitted for diarrhea from January 2003 through December 2005, and 852 children <5 years of age were treated for diarrhea at BH during 2004-2005. We examined stool specimens from 450 children (53%) at BH and from 1870 children (73%) admitted to DGM. An estimated 22.8% (95% confidence interval [CI], 21.2%-24.5%) of the children hospitalized with diarrhea at DGM were rotavirus positive, and the corresponding figure at BH was 18.2% (95% CI, 14.9%-22.1%). Among children <5 years of age admitted to DGM for any reason, an estimated 5.5% (95% CI, 5.1%-6.0%) had rotavirus diarrhea. Our incidence estimates suggest that 1 in 43-62 children in the area is likely to be hospitalized with rotavirus diarrhea by 2 years of age.
  
  
  CONCLUSIONS
  Prevention of serious rotavirus illness by vaccination will substantially reduce not only the disease burden among young children but also the case load in South African health care facilities.
authors.affiliation: MRC Diarrhoeal Pathogens Research Unit, University of Limpopo, Pretoria, South Africa.
authors.forename: Seheri Luyanda
authors.initials: SL
authors.lastname: Mapaseka
authors.forename: John Barr
authors.initials: JB
authors.lastname: Dewar
authors.forename: Lize
authors.initials: L
authors.lastname: van der Merwe
authors.forename: Annelise
authors.initials: A
authors.lastname: Geyer
authors.forename: John
authors.initials: J
authors.lastname: Tumbo
authors.forename: Monika
authors.initials: M
authors.lastname: Zweygarth
authors.forename: Pieter
authors.initials: P
authors.lastname: Bos
authors.forename: Mathew Dioh
authors.initials: MD
authors.lastname: Esona
authors.forename: A Duncan
authors.initials: AD
authors.lastname: Steele
authors.forename: Halvor
authors.initials: H
authors.lastname: Sommerfelt
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000821:virology; D005243:Feces / Q000821:virology; D006760:Hospitalization / Q000706:statistics & numerical data; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D011159:Population Surveillance; D011446:Prospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology*; D012621:Seasons; D013019:South Africa / Q000453:epidemiology; D013997:Time Factors