title: Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.
abstract: OBJECTIVE
  The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms.
  
  
  METHODS
  We examined the intensity of intraamniotic and maternal inflammatory responses in 99 patients with preterm premature rupture of membranes and a positive amniotic fluid (AF) culture. AF was obtained by transabdominal amniocentesis or at the time of cesarean delivery. Patients were divided according to the recovered microorganisms: (1) genital mycoplasmas (n = 62); (2) other microorganisms (n = 31); or (3) mixed infection (n = 6).
  
  
  RESULTS
  The median AF white blood cell (WBC) count, maternal blood WBC count, and plasma C-reactive protein concentrations were significantly higher in patients with intraamniotic infection with genital mycoplasmas than in those with intraamniotic infection with other microorganisms (P < .05 for each).
  
  
  CONCLUSIONS
  Intraamniotic and maternal inflammatory responses are more intense in intraamniotic infection with genital mycoplasmas than in intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kyung Joon
authors.initials: KJ
authors.lastname: Oh
authors.forename: Kyung A
authors.initials: KA
authors.lastname: Lee
authors.forename: Yoo-Kyung
authors.initials: YK
authors.lastname: Sohn
authors.forename: Chan-Wook
authors.initials: CW
authors.lastname: Park
authors.forename: Joon-Seok
authors.initials: JS
authors.lastname: Hong
authors.forename: Roberto
authors.initials: R
authors.lastname: Romero
authors.forename: Bo Hyun
authors.initials: BH
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism / Q000382:microbiology*; D002097:C-Reactive Protein / Q000032:analysis; D002585:Cesarean Section; D002821:Chorioamnionitis / Q000382:microbiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology*; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000378:metabolism; D009175:Mycoplasma Infections / Q000453:epidemiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*
chemical_list: D002097:C-Reactive Protein