title: A case study progression to multiple myeloma.
abstract: Multiple myeloma consistently is preceded by precursor states, which often are diagnosed incidentally in the laboratory. This case report illustrates the clinical dilemma of progression from precursor to full malignancy. The article also discusses future directions in management and research focusing on myelomagenesis.
authors.affiliation: Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. yanceym@mail.nih.gov
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Yancey
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Waxman
authors.forename: Ola
authors.initials: O
authors.lastname: Landgren
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D008297:Male; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D018570:Risk Assessment; D016103:Spinal Fractures / Q000209:etiology