Proteomics and biomarkers for ovarian cancer diagnosis.
Ovarian cancer remains a leading cause of death from gynecological malignancy. Early diagnosis is the most important determinant of survival. Current diagnostic tools have had very limited success in early detection. In recent years, the advancing techniques for proteomics have accelerated the discovery of ovarian cancer biomarkers. Numerous proteomics-based molecular biomarkers/panels have been identified and hold great potential for diagnostic applications, but they need further development and validation. This article reviews recently published data on the diagnosis of ovarian cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development.
Zhang
Bei
B
Department of Biomedicine, Women's Hospital, University of Basel, Basel, Switzerland.
Barekati
Zeinab
Z
Kohler
Corina
C
Radpour
Ramin
R
Asadollahi
Reza
R
Holzgreve
Wolfgang
W
Zhong
Xiao Yan
XY
D014408:Biomarkers, Tumor / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D040901:Proteomics
D014408:Biomarkers, Tumor