title: Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.
abstract: We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, perhaps, other species within an ecosystem.
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Goldberg
authors.forename: Pavlo
authors.initials: P
authors.lastname: Kyryakov
authors.forename: Simon D
authors.initials: SD
authors.lastname: Bourque
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Titorenko
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D054697:Cytostatic Agents / Q000378:metabolism; D017753:Ecosystem; D008095:Lithocholic Acid; D008136:Longevity / Q000502:physiology; D008322:Mammals / Q000502:physiology; D008928:Mitochondria / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D020123:Sirolimus / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism; D015003:Yeasts / Q000502:physiology
chemical_list: D054697:Cytostatic Agents; D015262:Xenobiotics; D008095:Lithocholic Acid; D058570:TOR Serine-Threonine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D020123:Sirolimus