title: The cocrystal nicotinamide-succinic acid (2/1).
abstract: In the asymmetric unit of the crystal structure of nicotinamide-succinic acid (2/1), 2C(6)H(6)N(2)O x C(4)H(6)O(4), there are two independent nicotinamide molecules in general positions and two half succinic acid molecules which lie about inversion centres. The structure contains acid-pyridine and amide-amide synthons with nicotinamide molecules forming ladders of alternating R(2)(2)(8) and R(4)(2)(8) rings linked through succinic acid to generate a corrugated hydrogen-bonded sheet. This sheet is a common supramolecular unit found in other 2:1 nicotinamide-dicarboxylic acid cocrystals, but the presence of two crystallographically distinct nicotinamides with anti and syn conformations, forming two distinct sheets within the same structure, is a novel packing feature in this type of material.
authors.affiliation: School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, England.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Thompson
authors.forename: Raja S
authors.initials: RS
authors.lastname: Voguri
authors.forename: Adam
authors.initials: A
authors.lastname: Cowell
authors.forename: Louise
authors.initials: L
authors.lastname: Male
authors.forename: Maryjane
authors.initials: M
authors.lastname: Tremayne
mesh_terms: D018360:Crystallography, X-Ray; D003998:Dicarboxylic Acids / Q000737:chemistry*; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure; D009536:Niacinamide / Q000737:chemistry*; D013237:Stereoisomerism; D019802:Succinic Acid / Q000737:chemistry*
chemical_list: D003998:Dicarboxylic Acids; D009536:Niacinamide; D019802:Succinic Acid