NbCl3-catalyzed intermolecular [2+2+2] cycloaddition of alkynes and alpha,omega-dienes: highly chemo- and regioselective formation of 5-omega-alkenyl-1,4-substituted-1,3-cyclohexadiene derivatives.
Intermolecular [2+2+2] cycloaddition of tert-butylacetylene with alpha,omega-dienes was successfully achieved by NbCl(3)(DME) catalyst to afford 5-omega-alkenyl-1,4-disubstituted-1,3-cyclohexadienes in excellent yields with high chemo- and regioselectivity.
Obora
Yasushi
Y
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering and ORDIST, Kansai University, Suita, Osaka 564-8680, Japan. obora@kansai-u.ac.jp
Satoh
Yasushi
Y
Ishii
Yasutaka
Y
D000466:Alkadienes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D053138:Cyclohexenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009556:Niobium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000466:Alkadienes; D000480:Alkynes; D053138:Cyclohexenes; D009942:Organometallic Compounds; D009556:Niobium; C034005:1,3-cyclohexadiene