title: Cerebrospinal fluid insulin during non-neurological surgery.
abstract: Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.
authors.affiliation: Forensic Psychiatry, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Sara
authors.initials: S
authors.lastname: Bromander
authors.forename: Rolf
authors.initials: R
authors.lastname: Anckarsäter
authors.forename: Bo
authors.initials: B
authors.lastname: Ahrén
authors.forename: Marianne
authors.initials: M
authors.lastname: Kristiansson
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Agneta
authors.initials: A
authors.lastname: Holmäng
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Henrik
authors.initials: H
authors.lastname: Anckarsäter
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Wass
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier / Q000502:physiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000134:cerebrospinal fluid*; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects*; D011183:Postoperative Complications / Q000097:blood / Q000134:cerebrospinal fluid* / Q000209:etiology; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D007328:Insulin