HBCD stereoisomer pattern in mirror carps following dietary exposure to pure gamma-HBCD enantiomers.
1,2,5,6,9,10-hexabromocyclododecane (HBCD) is a brominated flame retardant consisting of a mixture of diastereomeric pairs of enantiomers that is a known omnipresent, environmental contaminant. The present study investigated the possibility of bioisomerization of HBCD stereoisomers. Therefore, mirror carps (Cyprinus carpio morpha noblis) were exposed to pure (+)- and (-)-gamma-HBCD, randomly sampled biweekly over a period of three and a half months and the fillets were subjected to enantiomer-specific determination of HBCD. Considering the background contamination of the fish at the beginning of the feeding period, significant enrichment of the respectively fed gamma-enantiomer was already detectable after two weeks of exposure. However, no significant enrichment of the respectively expected alpha-enantiomer was observed within this period. Thus, no evidence for the isomerization of HBCD stereoisomers was found in mirror carp under the applied conditions.
Esslinger
Susanne
S
BAM Federal Institute for Materials Research and Testing, Richard-Willstatter-Strasse 11, 12489 Berlin, Germany.
Becker
Roland
R
Müller-Belecke
Andreas
A
Bremser
Wolfram
W
Jung
Christian
C
Nehls
Irene
I
D000818:Animals; D002347:Carps; D006842:Hydrocarbons, Brominated / Q000737:chemistry* / Q000633:toxicity; D013237:Stereoisomerism
D006842:Hydrocarbons, Brominated; C089796:hexabromocyclododecane