title: Naturally-occurring canine herpesvirus-1 infection of the vestibular labyrinth and ganglion of dogs.
abstract: Although the involvement of herpesviruses in vestibular disease of humans has been recognised for many years, knowledge of such a link in companion animal species is restricted to cats. This study was conducted to assess the prevalence of canine herpesvirus-1 (CaHV-1) infection of the vestibular labyrinth (VL) and vestibular ganglion (VG) of dogs by PCR. 'Field' herpesvirus was detected in the VL of 17% and in the VG of 19% of 52 dogs, respectively. None of the 11 dogs with infected VG and/or VL exhibited signs of vestibular disease, whereas clinical signs in the remaining three animals were attributable to intra-cranial neoplasia. As reported for other species, the putative role of herpesvirus infection in canine vestibular disease requires further elucidation.
authors.affiliation: General Pathology and Neuropathology, Institute of Veterinary Pathology, Department of Veterinary Clinical Sciences, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Parzefall
authors.forename: Andrea
authors.initials: A
authors.lastname: Fischer
authors.forename: Andreas
authors.initials: A
authors.lastname: Blutke
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schmahl
authors.forename: Kaspar
authors.initials: K
authors.lastname: Matiasek
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D005260:Female; D017950:Ganglia, Sensory / Q000821:virology*; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000662:veterinary*; D002184:Herpesvirus 1, Canid / Q000302:isolation & purification*; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015995:Prevalence; D014722:Vestibule, Labyrinth / Q000821:virology*
chemical_list: D004279:DNA, Viral