Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy.
A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhibitor efficacy. Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics.
Lu
Shaoying
S
Department of Bioengineering & Beckman Institute for Advanced Science and Technology, Neuroscience Program, Center of Biophysics and Computational Biology, Institute of Genomic Biology, University of Illinois at Urbana-Champaign, 405 N. Mathews Avenue, Urbana, IL 61801, USA.
Wang
Yingxiao
Y
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D019008:Drug Resistance, Neoplasm; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy
D014408:Biomarkers, Tumor