In vitro and in vivo studies of single-walled carbon nanohorns with encapsulated metallofullerenes and exohedrally functionalized quantum dots.
Single-walled carbon nanohorns (SWNHs) are new carbonaceous materials. In this paper, we report the first successful preparation of SWNHs encapsulating trimetallic nitride template endohedral metallofullerenes (TNT-EMFs). The resultant materials were functionalized by a high-speed vibration milling method and conjugated with CdSe/ZnS quantum dots (QDs). The successful encapsulation of TNT-EMFs and external functionalization with QDs provide a dual diagnostic platform for in vitro and in vivo biomedical applications of these new carbonaceous materials.
Zhang
Jianfei
J
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, USA.
Ge
Jiechao
J
Shultz
Michael D
MD
Chung
Eunna
E
Singh
Gurpreet
G
Shu
Chunying
C
Fatouros
Panos P
PP
Henderson
Scott C
SC
Corwin
Frank D
FD
Geohegan
David B
DB
Puretzky
Alex A
AA
Rouleau
Christopher M
CM
More
Karren
K
Rylander
Christopher
C
Rylander
Marissa Nichole
MN
Gibson
Harry W
HW
Dorn
Harry C
HC
D037741:Fullerenes / Q000737:chemistry*; D066298:In Vitro Techniques; D008670:Metals / Q000737:chemistry*; D037742:Nanotubes, Carbon; D045663:Quantum Dots
D037741:Fullerenes; D008670:Metals; D037742:Nanotubes, Carbon