Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair.
The proper choice of repair pathway is critical to tolerating various types of DNA damage. In a recent issue of Molecular Cell, Adamo et al. (2010), along with a second report (Pace et al., 2010), describe how the Fanconi anemia (FA) pathway is involved in preventing aberrant DNA repair. These studies suggest a potentially significant new opportunity for the treatment of FA.
Bunting
Samuel F
SF
Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nussenzweig
André
A