title: Reversal of intractable hypoxemia with exogenous surfactant (calfactant) facilitating complete neurological recovery in a pediatric drowning victim.
abstract: OBJECTIVE
  To report the successful reversal of intractable hypoxemia after exogenous surfactant (calfactant) administration, facilitating neurological recovery in a toddler cold-water drowning victim with significant circulatory arrest time.
  
  
  METHODS
  Case report and review of literature.
  
  
  RESULTS
  A 2(1/2)-year-old girl cold-water drowning victim with severe, intractable hypoxemia after submersion time of approximately 15 minutes and arrest time of approximately 45 minutes was given 80 mL/m of calfactant endotracheally with reversal of her hypoxemia and eventual neurologically intact survival.
  
  
  CONCLUSIONS
  Surfactant replacement with calfactant is a rational, useful, and potentially lifesaving treatment for acute hypoxemic respiratory failure due to drowning.
authors.affiliation: Division of Pediatric Critical Care Medicine and daggerDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA. bvarsico@peds.uab.edu
authors.forename: Brian Michael
authors.initials: BM
authors.lastname: Varisco
authors.forename: Crystal Marie
authors.initials: CM
authors.lastname: Palmatier
authors.forename: Jeffrey Allen
authors.initials: JA
authors.lastname: Alten
mesh_terms: D001688:Biological Products / Q000008:administration & dosage*; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D002490:Central Nervous System / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D002675:Child, Preschool; D004332:Drowning; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000628:therapy*; D011663:Pulmonary Surfactants / Q000008:administration & dosage; D020127:Recovery of Function; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000628:therapy*; D014132:Trachea
chemical_list: D001688:Biological Products; D011663:Pulmonary Surfactants; C117342:calfactant