title: Efficacy of lanolin and bovine type I collagen in the treatment of childhood anal fissures: a prospective, randomized, controlled clinical trial.
abstract: OBJECTIVE
  We designed an open-labeled, prospective, randomized, controlled clinical trial to test the efficacy of topical lanolin ointment (PureLan) and bovine type I collagen spray (Gelfix) in the treatment of childhood anal fissures.
  
  
  METHODS
  Seventy-one children with acute anal fissure were divided randomly into three groups: group I (control; n = 25), group II (PureLan; n = 28), and group III (Gelfix; n = 18). All children were assigned to have warm sitz baths, topical analgesic creams, and stool softeners. Patients in groups II and III were also treated with topical lanolin ointment and bovine type I collagen, respectively. All children were re-examined 4 weeks later.
  
  
  RESULTS
  Complete healing of the anal fissure was observed in 68% of the group I patients, but in 92.9% and 100% of the group II and III patients, respectively. The difference among groups was significant in terms of complete fissure healing (P = 0.003), but the efficacy of topical lanolin ointment and bovine type I collagen spray did not differ significantly (P = 0.078).
  
  
  CONCLUSIONS
  Our data suggest that topical lanolin ointment and bovine type I collagen spray are effective in the treatment of acute anal fissure in children.
authors.affiliation: Department of Pediatric Surgery, Süleyman Demirel University Medical School, 32260, Isparta, Turkey.
authors.forename: Behçet Ilker
authors.initials: BI
authors.lastname: Büyükyavuz
authors.forename: Cagri
authors.initials: C
authors.lastname: Savaş
authors.forename: Levent
authors.initials: L
authors.lastname: Duman
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D024042:Collagen Type I / Q000627:therapeutic use*; D003358:Cosmetics / Q000627:therapeutic use*; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007809:Lanolin / Q000627:therapeutic use*; D008297:Male; D011347:Procollagen / Q000627:therapeutic use*
chemical_list: D024042:Collagen Type I; D003358:Cosmetics; D011347:Procollagen; D007809:Lanolin