Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(I) and Tc(I) carborane complexes.
Carboranes form stable complexes with the [M(CO)(3)](+) (M = (99m)Tc, Re) core and are viable ligands for the development of targeted radiopharmaceuticals. (99m)Tc-carborane complexes were found to exhibit substantially different 1,2-->1,7 cage isomerisation behaviour than their Re counterparts, challenging the validity of the routine use of rhenium as a surrogate for the development of technetium-99m based molecular imaging agents.
Armstrong
Andrea F
AF
McMaster Institute for Applied Radiation Sciences, McMaster University Hamilton, ON, Canada.
Valliant
John F
JF
D001880:Boranes / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D007536:Isomerism; D007553:Isotope Labeling; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon
D001880:Boranes; D056831:Coordination Complexes; D019275:Radiopharmaceuticals; D012211:Rhenium; D013667:Technetium