A novel dry powder inhaler: Effect of device design on dispersion performance.
The effect of device geometry and film characteristics on the performance of several passive flutter-induced dispersion DPI prototypes was investigated. Device resistance measurements indicated that the type of films, type of device geometry and specific device dimensions significantly affects the airflow resistance of the device. It was found that airflow resistance was positively correlated to the turbulence generated within the device. In addition, in vitro deposition studies indicated that the device geometry and film properties have a significant effect on aerosol dispersion performance. From these studies, selected prototypes were observed to have improved aerosolization performance without significant increases in device resistance. With further device design optimization, flutter induced dispersion DPI may be highly efficient mechanism for drug deaggregation and aerosolization.
Selvam
Parthiban
P
College of Pharmacy, University of Texas at Austin, Austin 78741, TX, United States.
McNair
Doug
D
Truman
Randall
R
Smyth
Hugh D C
HD
D000280:Administration, Inhalation; D000336:Aerosols / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry; D058995:Dry Powder Inhalers; D004867:Equipment Design; D013499:Surface Properties
D000336:Aerosols; D000890:Anti-Infective Agents; D002939:Ciprofloxacin