Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster.
Anti-NMDA-receptor encephalitis was initially described as a paraneoplastic disorder in young women with ovarian teratoma. We report on a 3-year-old boy who developed anti-NMDA-receptor encephalitis one month after a respiratory infection. Moreover, array-comparative genomic hybridization in this patient revealed an inherited microdeletion in chromosomeband 6p21.32, including the HLA-DPB1 and HLA-DPB2 genes. The clinical relevance of this microdeletion is discussed.
Verhelst
Helene
H
Department of Paediatric Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. helene.verhelst@ugent.be
Verloo
Patrick
P
Dhondt
Karlien
K
De Paepe
Boel
B
Menten
Björn
B
Dalmau
Josep
J
Van Coster
Rudy
R
D001323:Autoantibodies / Q000096:biosynthesis*; D002675:Child, Preschool; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004660:Encephalitis / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*
D001323:Autoantibodies; D006681:HLA-D Antigens; D016194:Receptors, N-Methyl-D-Aspartate