Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics.
Oligosaccharides represent potentially useful scaffolds for the development of peptidomimetics. We report here the design and synthesis of functionalized trisaccharides modeled after an α-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2. The trisaccharide scaffold was obtained efficiently by applying the sulfoxide glycosylation reaction as a key methodology.
Sakurai
Kaori
K
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA and Department of Biological Cellular and Molecular Pharmacology, Harvard Medical School, Longwood, Boston, MA.
Kahne
Daniel
D