Diabetes and 15-year cardiovascular mortality in a Chinese population: Differential impact of hypertension and metabolic syndrome.
BACKGROUND
It remains unclear if the risk for cardiovascular (CV) mortality in patients with diabetes mellitus (DM) is equivalent to that in patients with a history of cardiac disease in Asian populations. The aims of the present study were to investigate whether or not non-heart disease (HD) DM subjects have a similar risk of CV mortality as HD patients without DM (non-DM HD), and whether or not hypertension (HT) or metabolic syndrome (MS) is a CV mortality marker for diabetic subjects identified from a community-based population.


METHODS
We followed 11,058 Chinese people aged > or = 30 years on Kinmen island for a median of 15.0 years.


RESULTS
The age-, sex- and smoking-adjusted hazard ratios for CV mortality were 3.56 [95% confidence interval (CI): 1.99-6.36] for DM subjects with HD, 1.64 (95% CI: 1.25-2.16) for DM without HD (non-HD DM) subjects, and 1.63 (95% CI: 1.09-2.44) for non-DM HD patients, when compared with subjects without DM and HD. Among the 827 non-HD DM subjects identified at the baseline survey, the age-, sex- and smoking-adjusted hazard ratios for CV mortality were 2.36 (95% CI: 1.30-4.28) for the presence versus absence of HT, and 1.23 (95% CI: 0.65-2.34) for the presence versus absence of MS.


CONCLUSIONS
Non-HD DM subjects had a similar risk of CV mortality to non-DM HD subjects in this Chinese population. The presence of HT but not MS substantially increased CV mortality risk in the DM subjects.
Chuang
Shao-Yuan
SY
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C.
Hsu
Pai-Feng
PF
Sung
Shih-Hsien
SH
Chou
Pesus
P
Chen
Chen-Huan
CH
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality*; D002681:China; D048909:Diabetes Complications / Q000401:mortality*; D003920:Diabetes Mellitus / Q000401:mortality*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000401:mortality*; D008297:Male; D024821:Metabolic Syndrome / Q000401:mortality*; D008875:Middle Aged