The effect of stereochemistry on sodium ion complexation in nucleoside-metallacarborane conjugates.
CONJUGATES OF PURINE AND PYRIMIDINE NUCLEOSIDES: thymidine and 2'-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and (23)Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.
Olejniczak
Agnieszka B
AB
Laboratory of Molecular Virology and Biological Chemistry, Institute for Medical Biology of the Polish Academy of Sciences, Lodowa 106, 93-232 Łódź, Poland.
Milecki
Jan
J
Schroeder
Grzegorz
G