Sulfuretin attenuates allergic airway inflammation in mice.
Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which is reported to inhibit the inflammatory response by suppressing the NF-κB pathway. Because NF-κB activation plays a pivotal role in the pathogenesis of allergic airway inflammation, we here examined the effect of sulfuretin on an ovalbumin-induced airway inflammation model in mice. We isolated sulfuretin from R. verniciflua. Sulfuretin was delivered intraperitoneally after the last ovalbumin challenge. Airway hyper-responsiveness, cytokines, mucin, and eosinophilic infiltration were analyzed in bronchoalveolar lavage fluid and lung tissue. A single administration of sulfuretin reduced airway inflammatory cell recruitment and peribronchiolar inflammation and suppressed the production of various cytokines in bronchoalveolar fluid. In addition, sulfuretin suppressed mucin production and prevented the development of airway hyper-responsiveness. The protective effect of sulfuretin was mediated by the inhibition of the NF-κB signaling pathway. Our results suggest that sulfuretin may have therapeutic potential for the treatment of allergic airway inflammation.
Song
Mi-Young
MY
Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756, South Korea.
Jeong
Gil-Saeng
GS
Lee
Haw-Suk
HS
Kwon
Keun-Sang
KS
Lee
Sang-Myeong
SM
Park
Jin-Woo
JW
Kim
Youn-Chul
YC
Park
Byung-Hyun
BH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001572:Benzofurans / Q000494:pharmacology / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D002633:Chemotaxis / Q000187:drug effects; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004802:Eosinophilia / Q000276:immunology; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009077:Mucins / Q000096:biosynthesis; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D011014:Pneumonia / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D012130:Respiratory Hypersensitivity / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; D016207:Cytokines; D005419:Flavonoids; D009077:Mucins; D016328:NF-kappa B; C054989:sulfuretin