title: Synthetic receptors with antibody-like binding affinities.
abstract: Antibodies are critical reagents in biological research and are increasingly being developed as therapeutic agents. They typically exhibit very high affinity and selectivity for their ligands. Synthetic protein-binding agents rarely achieve the combination of high affinity and selectivity for their target protein that is typical of a good antibody. However, significant efforts are underway to develop a new generation of protein ligands with improved properties. This article reviews progress towards this goal and suggests fruitful strategies for future research.
authors.affiliation: Departments of Chemistry & Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. kodadek@scripps.edu
authors.forename: Thomas
authors.initials: T
authors.lastname: Kodadek
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D010455:Peptides / Q000737:chemistry; D054852:Small Molecule Libraries
chemical_list: D000906:Antibodies; D008024:Ligands; D010455:Peptides; D054852:Small Molecule Libraries