Prospects for minocycline neuroprotection.
Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system.
Plane
Jennifer M
JM
Department of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, 95817, USA.
Shen
Yan
Y
Pleasure
David E
DE
Deng
Wenbin
W
D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D004195:Disease Models, Animal; D006801:Humans; D008911:Minocycline / Q000494:pharmacology / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
D018696:Neuroprotective Agents; D008911:Minocycline