Does C-reactive protein predict recurrent preeclampsia?
OBJECTIVE
Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia.


METHODS
Serum samples collected longitudinally in women with previous preeclampsia from the Maternal-Fetal Medicine Units Network trial of aspirin to prevent preeclampsia were assayed for CRP.


RESULTS
Of 255 women studied, 50 developed recurrence. Baseline C-reactive protein concentration was similar between women who did and did not recur. After adjusting for confounders, neither elevated baseline C-reactive protein nor its change over gestation was associated with recurrence.


CONCLUSIONS
In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.
Gammill
Hilary S
HS
Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA, USA. hgammill@u.washington.edu
Powers
Robert W
RW
Clifton
Rebecca G
RG
Van Dorsten
J Peter
JP
Klebanoff
Mark A
MA
Lindheimer
Marshall D
MD
Sibai
Baha
B
Landon
Mark B
MB
Miodovnik
Menachem
M
Dombrowski
Mitchell
M
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012008:Recurrence; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein