A MAP for bundling microtubules.
Microtubules assemble into arrays of bundled filaments that are critical for multiple steps in cell division, including anaphase and cytokinesis. Recent structural and functional studies, including two papers in this issue of Cell (Bieling et al., 2010; Subramanian et al., 2010), demonstrate how the MAP65 protein PRC1 crosslinks microtubules and cooperates with kinesin motors to control the dynamics and size of bundled regions.
Walczak
Claire E
CE
Medical Sciences, Indiana University, Bloomington, IN 47405, USA. cwalczak@indiana.edu
Shaw
Sidney L
SL
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*
D018797:Cell Cycle Proteins; D008869:Microtubule-Associated Proteins; D016547:Kinesins