title: A case of anaphylaxis to oral minocycline.
abstract: Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. To date, there has been only one case report of anaphylaxis to minocycline. We report here a case of anaphylaxis to oral minocycline. A 56-yr-old woman visited our hospital after three episodes of recurrent anaphylaxis. We performed an oral challenge test, the standard method for diagnosing drug allergies, with minocycline, one of the drugs she had taken previously. She developed urticaria, angioedema, nausea, vomiting, hypotension, and dyspnea within 4 min and was treated with intramuscular epinephrine, intravenous antihistamine and systemic corticosteroid. However, she presented similar symptoms at 50 min and at 110 min. In prescribing oral minocycline, physicians should consider the possibility of serious adverse reactions, such as anaphylaxis.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Ji Woong
authors.initials: JW
authors.lastname: Jang
authors.forename: Yun-Jeong
authors.initials: YJ
authors.lastname: Bae
authors.forename: Yong Giun
authors.initials: YG
authors.lastname: Kim
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Jin
authors.forename: Kyung Sun
authors.initials: KS
authors.lastname: Park
authors.forename: You Sook
authors.initials: YS
authors.lastname: Cho
authors.forename: Hee-Bom
authors.initials: HB
authors.lastname: Moon
authors.forename: Tae-Bum
authors.initials: TB
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline