Effect of black-currant extract on negative lens-induced ocular growth in chicks.
OBJECTIVE
To evaluate the effects of orally administered black-currant (BC) extract on the enlargement of globe component dimensions induced in chicks by wearing negative lenses.


METHODS
Negative lenses (-8 D) were worn on the right eyes by 8-day-old chicks, and their fellow eyes acted as controls. BC extract and distilled water (vehicle control) were orally administered once a day for 3 days. To confirm the effect of BC anthocyanins (BCAs), they were intravenously administered once a day for 3 days. Dimensions of globe components of right eyes and fellow eyes were measured with an A-scan ultrasound instrument on the third day (day 4) after placement of the negative lenses.


RESULTS
Orally administered BC extract significantly inhibited enlargement of vitreous-chamber depth, axial and ocular lengths in a dose-dependent manner when compared to controls. Intravenously administered BCAs also inhibited elongation of vitreous-chamber depth and axial length when compared to controls.


CONCLUSIONS
This is the first evidence that BC extract and BCAs could inhibit enlargement of globe component dimensions in a negative lens-induced chick myopia model.
Iida
Hiroyuki
H
Food and Health R&D Laboratories, Meiji Seika Kaisha Ltd., Sakado, Japan. hiroyuki_iida@meiji.co.jp
Nakamura
Yuko
Y
Matsumoto
Hitoshi
H
Takeuchi
Yasuo
Y
Harano
Shokichi
S
Ishihara
Mamoru
M
Katsumi
Osamu
O
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D058452:Axial Length, Eye / Q000000981:diagnostic imaging / Q000187:drug effects*; D002645:Chickens; D003261:Contact Lenses / Q000009:adverse effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D009216:Myopia / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage*; D057972:Posterior Eye Segment / Q000187:drug effects / Q000648:ultrastructure; D031965:Ribes; D014463:Ultrasonography
D010936:Plant Extracts