Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies.
A handheld-probe-based optical imager has recently been developed toward three-dimensional tomography. In this study, the improvement of target depth recovery was demonstrated using a multi-projection technique on large slab phantoms using 0.45 cc fluorescing target(s) (with 1:0 contrast ratio) of 1.5 to 2.5 cm deep. Tomographic results using single- and multi- (here dual) projection measurements (with and without a priori information of target location) were compared. In all experimental cases, the use of multi-projection measurements along with a priori information recovered target depth and location closer to their true values, demonstrating its applicability for clinical translation.
Ge
Jiajia
J
Department of Biomedical Engineering, Optical Imaging Laboratory, EC 2675, Florida International University, 10555 West Flagler Street, Miami, Florida 33174, USA. gejiajia@gmail.com
Erickson
Sarah J
SJ
Godavarty
Anuradha
A
D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000175:diagnosis*; D005260:Female; D005453:Fluorescence; D006801:Humans; D021621:Imaging, Three-Dimensional; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*