title: Role of substance P in viral myocarditis in mice.
abstract: Substance P (SP) is widely expressed in the central nervous system and in peripheral tissues such as myocardial nerves. We examined SP in viral myocarditis in mice induced by encephalomyocarditis virus (EMCV). Localization of SP in the hearts was examined immunohistochemically, and concentrations of SP in hearts and sera were measured by enzyme immunoassay. Substance P levels and density of SP-containing cells in murine hearts on day 6 after EMCV inoculation were decreased compared with those in normal controls. There was a negative correlation between SP levels in the hearts and ratio of heart weight to body weight of the mice at 6 days. Circulating SP levels were decreased in mice on day 6 after EMCV inoculation, and further decreased on day 14. Substance P in hearts and sera is decreased in viral myocarditis in mice, suggesting that SP may play a role in the pathogenesis of viral myocarditis, and that interaction of the neuropeptide nervous system and mast-cell immune system is important in the pathogenesis of viral myocarditis.
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawaracho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Miho
authors.initials: M
authors.lastname: Shimada
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
authors.forename: Dayi
authors.initials: D
authors.lastname: Hu
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Nishio
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumori
mesh_terms: D000818:Animals; D018188:Cardiovirus Infections / Q000378:metabolism* / Q000821:virology; D004195:Disease Models, Animal; D004686:Encephalomyocarditis virus / Q000472:pathogenicity*; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009205:Myocarditis / Q000378:metabolism* / Q000821:virology; D009206:Myocardium / Q000378:metabolism*; D013373:Substance P / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013373:Substance P