title: A clinical study on the management of generalized anxiety disorder with Centella asiatica.
abstract: Centella asiatica is reputed for its beneficial effects in various neurological disorders. The present investigation was undertaken to evaluate the role of 70% hydro-ethanolic extract of Centella asiatica (CA) on generalized anxiety disorder (GAD) in man. Hamilton's Brief Psychiatric Rating Scale (BPRS) was used to screen the subjects. Thirty-three participants (18 male and 15 female; average age 33 yrs) were medicated with the CA in a fixed dose regime (500 mg/capsule, twice daily, after meal). They were thoroughly investigated using standard questionnaires based on psychological rating scale at baseline (day 0), mid-term (day 30) and final (day 60). The scale also includes a number of direct queries about current levels of experienced stress. The observations revealed that, CA not only significantly (p<0.01) attenuated anxiety related disorders but it also significantly (p<0.01) reduced stress phenomenon and its correlated depression. CA further significantly (p<0.01) improved the willingness for adjustment and cognition. Results indicated that Centella asiatica may be useful in the treatment of GAD and may be used as a promising anxiolytic agent in near future.
authors.affiliation: JB Roy State Ayurvedic Medical College and Hospital, Kolkata, India.
authors.forename: U
authors.initials: U
authors.lastname: Jana
authors.forename: T K
authors.initials: TK
authors.lastname: Sur
authors.forename: L N
authors.initials: LN
authors.lastname: Maity
authors.forename: P K
authors.initials: PK
authors.lastname: Debnath
authors.forename: D
authors.initials: D
authors.lastname: Bhattacharyya
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy*; D028041:Centella; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts; D014315:Triterpenes / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: C526146:Centella asiatica extract; D010936:Plant Extracts; D014315:Triterpenes