On a novel coalescent model for genome-wide evolution of copy number variations.
Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model will hopefully lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes.
Mitrofanova
Antonina
A
Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, New York, NY, 10003, USA. antonina@cs.nyu.edu
Mishra
Bhubaneswar
B
D056915:DNA Copy Number Variations / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D015233:Models, Statistical