title: [Fetal hepatosplenomegaly in the third trimester: A sign of leukemia in fetuses with Down syndrome].
abstract: Risk for leukemic conditions increases in individuals with Down syndrome. We report a third trimester antenatal diagnosis of leukemia in a Down syndrome fetus. The third trimester ultrasound examination revealed a hepatosplenomegaly, which may suggest a myelopoiesis disorder. A review of the literature of eight cases described antenatally and 14 cases in the immediate neonatal period is presented.
authors.affiliation: Pôle mère-enfant, service gynécologie-obstétrique, centre hospitalier régional d'Orléans, BP 2439, 45032 Orléans cedex 1, France. chloe.fouche@hotmail.fr
authors.forename: C
authors.initials: C
authors.lastname: Fouché
authors.forename: A
authors.initials: A
authors.lastname: Ramos
authors.forename: O
authors.initials: O
authors.lastname: Esperandieu
authors.forename: S
authors.initials: S
authors.lastname: Briault
authors.forename: J-G
authors.initials: JG
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Desroches
mesh_terms: D000328:Adult; D000649:Amniocentesis; D004314:Down Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000196:embryology; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D005602:France; D005865:Gestational Age; D006529:Hepatomegaly / Q000150:complications / Q000000981:diagnostic imaging* / Q000196:embryology; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000175:diagnosis* / Q000196:embryology; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D013163:Splenomegaly / Q000150:complications / Q000000981:diagnostic imaging* / Q000196:embryology; D016216:Ultrasonography, Prenatal