Dietary unsaturated fatty acids and risk of mild cognitive impairment.
An increasing body of epidemiological evidence suggested that elevated saturated fatty acids could have negative effects on age-related cognitive decline (ARCD) and mild cognitive impairment (MCI). Furthermore, a clear reduction of risk for cognitive decline has been found in population samples with elevated fish consumption, high intake of monounsaturated fatty acids, and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. In the present article, on the basis of increasing body of evidence from cross-sectional and longitudinal population-based studies, we discussed the issue of the possible impact of dietary PUFA (both n-6 and n-3) on ARCD, MCI, and Alzheimer's disease.
Panza
Francesco
F
Geriatric Unit and Gerontology-Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Frisardi
Vincenza
V
Seripa
Davide
D
Imbimbo
Bruno P
BP
Pilotto
Alberto
A
Solfrizzi
Vincenzo
V
D003072:Cognition Disorders / Q000453:epidemiology*; D004041:Dietary Fats / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D012306:Risk
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated