title: Concise approach toward tetrazolo[1,5-a][1,4]benzodiazepines via a novel multicomponent isocyanide-based condensation.
abstract: A novel and efficient method for the synthesis of heteroannulated [1,4]benzodiazepines via an isocyanide-based multicomponent reaction is reported. The tetrazolo[1,5-a][1,4]benzodiazepines were obtained by a facile azide Ugi five-center four-component reaction (U-5C-4CR) using ketones, sodium azide, ammonium chloride, and corresponding isocyanide. The aforementioned tetrazolodiazepines represent a notable class of compounds with proven platelet aggregation inhibitory and cholecystokinin agonist activities.
authors.affiliation: A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Science, 29, Leninsky Avenue, Moscow 119991, Russia.
authors.forename: Roman S
authors.initials: RS
authors.lastname: Borisov
authors.forename: Anatoliy I
authors.initials: AI
authors.lastname: Polyakov
authors.forename: Lidia A
authors.initials: LA
authors.lastname: Medvedeva
authors.forename: Victor N
authors.initials: VN
authors.lastname: Khrustalev
authors.forename: Natalia I
authors.initials: NI
authors.lastname: Guranova
authors.forename: Leonid G
authors.initials: LG
authors.lastname: Voskressensky
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D002766:Cholecystokinin / Q000819:agonists*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D009570:Nitriles; D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D001569:Benzodiazepines; D002766:Cholecystokinin