Vitamin D in atopic dermatitis, asthma and allergic diseases.
This review examines the scientific evidence behind the hypothesis that vitamin D plays a role in the pathogenesis of allergic diseases, along with a focus on emerging data regarding vitamin D and atopic dermatitis. Elucidated molecular interactions of vitamin D with components of the immune system and clinical data regarding vitamin D deficiency and atopic diseases are discussed. The rationale behind the sunshine hypothesis, laboratory evidence supporting links between vitamin D deficiency and allergic diseases, the clinical evidence for and against vitamin D playing a role in allergic diseases, and the emerging evidence regarding the potential use of vitamin D to augment the innate immune response in atopic dermatitis are reviewed.
Searing
Daniel A
DA
Division of Pediatric Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, K731a, Denver, CO 80206, USA.
Leung
Donald Y M
DY
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics; D001249:Asthma / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D056747:Immunomodulation; D007381:Intermediate Filament Proteins / Q000235:genetics; D011110:Polymorphism, Genetic; D015995:Prevalence; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D012307:Risk Factors; D014807:Vitamin D / Q000276:immunology / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology
D023181:Antimicrobial Cationic Peptides; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D018167:Receptors, Calcitriol; D014807:Vitamin D