title: Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles.
abstract: Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA.
authors.forename: Courtney R
authors.initials: CR
authors.lastname: Thomas
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Ferris
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Choi
authors.forename: Mi Hyeon
authors.initials: MH
authors.lastname: Cho
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Kim
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
authors.forename: Jeon-Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D012822:Silicon Dioxide; D004317:Doxorubicin