title: High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses.
abstract: Reassortment is an important mechanism for the evolution of influenza viruses. Here, we coinfected cultured cells with the pandemic swine-origin influenza virus (S-OIV) and a contemporary H5N1 virus and found that these two viruses have high genetic compatibility. Studies of human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. We conclude that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.
authors.affiliation: Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Cássio Pontes
authors.initials: CP
authors.lastname: Octaviani
authors.forename: Makoto
authors.initials: M
authors.lastname: Ozawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Hideo
authors.initials: H
authors.lastname: Goto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002460:Cell Line; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology; D058873:Pandemics; D016865:Reassortant Viruses / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D013045:Species Specificity; D013552:Swine / Q000821:virology; D014774:Virulence / Q000235:genetics