title: Brain temperature profiles during epidural cooling with the ChillerPad in a monkey model of traumatic brain injury.
abstract: Therapeutic hypothermia remains a promising treatment for patients with severe traumatic brain injury (TBI). Multiple animal studies have suggested that hypothermia is neuroprotective after TBI, but clinical trials have been inconclusive. Systemic hypothermia, the method used in almost all major clinical trials, is limited by the time to target temperature, the depth of hypothermia, and complications, problems that may be solved by selective brain cooling. We evaluated the effects on brain temperature of a cooling device called the ChillerPad,™ which is applied to the dura in a non-human primate TBI model using controlled cortical impact (CCI). The cortical surface was rapidly cooled to approximately 15°C and maintained at that level for 24 h, followed by rewarming over about 10 h. Brain temperatures fell to 34-35°C at a depth of 15 mm at the cortical gray/white matter interface, and to 28-32°C at 10 mm deep. Intracranial pressure was mildly elevated (8-12 mm Hg) after cooling and rewarming, likely due to TBI. Other physiological variables were unchanged. Cooling was rapidly diminished at points distant from the cooling pad. The ChillerPad may be useful for highly localized cooling of the brain in circumstances in which a craniotomy is clinically indicated. However, because of the delay required by the craniotomy, other methods that are more readily available for inducing hypothermia may be used as a bridge between the time of injury to placement of the ChillerPad.
authors.affiliation: Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. kingcc@upmc.edu
authors.forename: Christopher
authors.initials: C
authors.lastname: King
authors.forename: Timothy
authors.initials: T
authors.lastname: Robinson
authors.forename: C Edward
authors.initials: CE
authors.lastname: Dixon
authors.forename: Gutti R
authors.initials: GR
authors.lastname: Rao
authors.forename: Donald
authors.initials: D
authors.lastname: Larnard
authors.forename: C Edwin M
authors.initials: CE
authors.lastname: Nemoto
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D007036:Hypothermia, Induced / Q000295:instrumentation* / Q000379:methods; D007427:Intracranial Pressure / Q000502:physiology; D008253:Macaca mulatta