title: Corneal collagen crosslinking in post-LASIK keratectasia.
abstract: OBJECTIVE
  To evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.
  
  
  METHODS
  Crosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised protocol (uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), slit-lamp examination, pachymetry and topography), was performed preoperatively 1, 3, 6 and 12 months after crosslinking.
  
  
  RESULTS
  The mean BCVA was 0.19 (SD ± 0.21) logMAR preoperatively, 0.25 (SD ± 0.17) 1 month, 0.20 (SD ± 0.20) 3 months, 0.18 (SD ± 0.21) 6 months and 0.15 (SD ± 0.14) 12 months postoperatively (statistically significant postop1-postop6, p=0.0335). The maximum k-readings were 44.12 (SD ± 3.97) preoperatively, 46.23 (SD ± 4.14) 1 month, 43.88 (SD ± 4.25) 3 months, 45.06 (SD ± 5.07) 6 months and 44.43 (SD ± 4.06) 12 months postoperatively (statistically significant preop-postop1, p=0.0281).
  
  
  CONCLUSIONS
  Crosslinking in patients with iatrogenic keratectasia stabilised the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilise the refraction and the corneal topography, and thus to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty.
authors.affiliation: Augenklinik, Technische Universität München, Ismaningerstr 22, 81675, Munich, Germany. josefina.salgado@gmx.net
authors.forename: J P
authors.initials: JP
authors.lastname: Salgado
authors.forename: R
authors.initials: R
authors.lastname: Khoramnia
authors.forename: C P
authors.initials: CP
authors.lastname: Lohmann
authors.forename: C
authors.initials: C
authors.lastname: Winkler von Mohrenfels
mesh_terms: D000328:Adult; D003094:Collagen / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy*; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000628:therapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011184:Postoperative Period; D011446:Prospective Studies; D012256:Riboflavin / Q000627:therapeutic use*; D014467:Ultraviolet Therapy / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin