title: Cilostazol may suppress restenosis and new contralateral carotid artery stenosis after carotid endarterectomy.
abstract: Carotid artery restenosis is a serious complication following carotid endarterectomy (CEA), so preventative management of the risk factors is important. The present study investigated the potential of cilostazol, a mediator of vascular stabilization as well as inhibitor of platelet aggregation, to suppress restenosis on the ipsilateral carotid artery and new plaque development on the contralateral carotid artery. Eighty-two patients treated by CEA were divided into two groups according to the postoperative antiplatelet aggregation drugs into the cilostazol and other groups. Patients were periodically examined for recurrence of the plaque on the ipsilateral side, development of plaque on the contralateral side, and the bilateral intermedia thicknesses measured by ultrasonographic examination for up to 6 years. Restenosis and development of the contralateral plaque were not detected in any patients in the cilostazol group, whereas such changes were found in seven patients in the other group. Cilostazol might be effective to inhibit the growth mechanism of plaque.
authors.affiliation: Department of Neurosurgery, Kashiwaba Neurosurgical Hospital, Toyohira-ku, Sapporo, Hokkaido, Japan. tetsu.yoshi@kashiwaba-nougeka.or.jp
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Shin
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Muraki
authors.forename: Rina
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshidumi
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tokuda
authors.forename: Sadao
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D000368:Aged; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000517:prevention & control* / Q000601:surgery; D000077407:Cilostazol; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000517:prevention & control*; D012307:Risk Factors; D055502:Secondary Prevention; D013777:Tetrazoles / Q000627:therapeutic use*; D014463:Ultrasonography
chemical_list: D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D000077407:Cilostazol