title: False-positive radio-iodinated metaiodobenzylguanidine (123I-MIBG) accumulation in a mast cell-infiltrated infantile haemangioma.
abstract: Radio-iodinated metaiodobenzylguanidine ((123)I-MIBG) is used for the detection and staging of neuroblastoma, pheochromcytoma and other neuroendocrine tumours in diagnostic nuclear medicine. A specific uptake and storage mechanism provides the basis for imaging with (123)I-MIBG. Nevertheless, cases of false-positive (123)I-MIBG scintigraphy with accumulation in non-chromaffin tumours have been described. Here, we present a case of a false-positive (123)I-MIBG scan in a case of a mast-cell infiltrated infantile haemangioma and discuss the possible uptake mechanism.
authors.affiliation: University Hospital Freiburg, Department of Nuclear Medicine, Hugstetter Strasse 55, 79106 Freiburg, Germany. christof.rottenburger@uniklinik-freiburg.de
authors.forename: C
authors.initials: C
authors.lastname: Rottenburger
authors.forename: E
authors.initials: E
authors.lastname: Juettner
authors.forename: A C
authors.initials: AC
authors.lastname: Harttrampf
authors.forename: M
authors.initials: M
authors.lastname: Hentschel
authors.forename: U
authors.initials: U
authors.lastname: Kontny
authors.forename: J
authors.initials: J
authors.lastname: Roessler
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006391:Hemangioma / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008407:Mast Cells / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine