title: Colletotrichum graminicola keratitis: first case report from India.
abstract: Colletotrichum graminicola is a medically important fungus belonging to the order Melanconiales under the class Coelomycetes. The members of the genus Colletotrichum are primarily plant pathogens which cause anthracnoses (fungal infection in plants). In the past few decades, they are progressively being implicated as etiological agents of subcutaneous hyalohyphomycoses and keratomycoses. Of the five medically important members in the genus Colletotrichum, keratitis due to Colletotrichum graminicola is rare. We diagnosed Colletotrichum graminicola keratitis in a 44-year-old man who presented with a non-healing corneal ulcer since three weeks. Positive smears and cultures from the corneal scrapings established the causative organism as C. graminicola. The patient was treated with a combination of oral ketoconazole and topical fluconazole and natamycin. Infection resolved over 10 weeks and antimicrobials were stopped. We describe the clinical presentation and treatment outcome of Colletotrichum graminicola keratitis.
authors.affiliation: Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, India.
authors.forename: Prakash P
authors.initials: PP
authors.lastname: Yegneswaran
authors.forename: Vijaya
authors.initials: V
authors.lastname: Pai
authors.forename: Indira
authors.initials: I
authors.lastname: Bairy
authors.forename: Sulatha
authors.initials: S
authors.lastname: Bhandary
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D020231:Colletotrichum; D003320:Corneal Ulcer / Q000382:microbiology; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000008:administration & dosage; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000382:microbiology*; D007654:Ketoconazole / Q000008:administration & dosage; D008297:Male; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy*; D010866:Natamycin / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D010866:Natamycin; D015725:Fluconazole; D007654:Ketoconazole