High density orthogonal surface immobilization via photoactivated copper-free click chemistry.
Surfaces containing reactive ester polymer brushes were functionalized with cyclopropenone-masked dibenzocyclooctynes for the light activated immobilization of azides using catalyst-free click chemistry. The photodecarbonylation reaction in the amorphous brush layer is first order for the first 45 s with a rate constant of 0.022 s(-1). The catalyst-free cycloaddition of surface bound dibeznocyclooctynes proceeds rapidly in the presence of azides under ambient conditions. Photolithography using a shadow mask was used to demonstrate patterning with multiple azide containing molecules. This surface immobilization strategy provides a general and facile platform for the generation of multicomponent surfaces with spatially resolved chemical functionality.
Orski
Sara V
SV
Department of Chemistry, Faculty of Engineering, and the Center for Nanoscale Science and Engineering, University of Georgia, Athens, Georgia 30602, USA.
Poloukhtine
Andrei A
AA
Arumugam
Selvanathan
S
Mao
Leidong
L
Popik
Vladimir V
VV
Locklin
Jason
J
D001386:Azides / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry; D004952:Esters; D008027:Light; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry; D013057:Spectrum Analysis; D013499:Surface Properties
D001386:Azides; D003521:Cyclopropanes; D004952:Esters; D011108:Polymers; C120343:cyclopropenone; D003300:Copper