title: Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics.
abstract: Oligosaccharides represent potentially useful scaffolds for the development of peptidomimetics. We report here the design and synthesis of functionalized trisaccharides modeled after an α-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2. The trisaccharide scaffold was obtained efficiently by applying the sulfoxide glycosylation reaction as a key methodology.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA and Department of Biological Cellular and Molecular Pharmacology, Harvard Medical School, Longwood, Boston, MA.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sakurai
authors.forename: Daniel
authors.initials: D
authors.lastname: Kahne