Parvovirus B19 and C-reactive protein in blood bank donors: implications for hygiene hypothesis research.
Exposure to certain environmental factors during childhood may influence the developing immune system, causing predisposing or protective effects toward development of autoimmune disorders. This study examines the hypothesis that past infection with parvovirus B19, a common childhood infection, is associated with altered levels of subclinical inflammatory activity in presumably healthy adults. Qualitative anti-parvovirus B19 IgG antibody and high-sensitivity C-reactive protein were determined in serum samples from adult blood bank donors. C-reactive protein values of B19 IgG-positive and B19 IgG-negative groups were compared. Analysis was performed on 282 blood bank donor serum samples. Among donors aged 17-49 years (n = 152), B19 IgG-positive samples (57.9%) were associated with significantly lower C-reactive protein levels compared with B19 IgG-negative samples (median C-reactive protein: 1.30 mg/l vs. 2.65 mg/l; p = 0.012 unadjusted (Mann-Whitney U-test); p = 0.014 adjusted for gender and age (logistic regression)). Among donors aged >49 years, median C-reactive protein levels were identical by B19 IgG status. The association of B19 IgG antibody with lower C-reactive protein levels in the serum of younger adults supports the hypothesis that infection in childhood may contribute long-term beneficial adaptive immune responses.
O'Bryan
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Division of General Internal Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA. tobryan@psu.edu
Wright
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D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D002097:C-Reactive Protein / Q000032:analysis*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006920:Hygiene; D007074:Immunoglobulin G / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000276:immunology; D016732:Parvovirus B19, Human / Q000276:immunology*; D055815:Young Adult
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D002097:C-Reactive Protein