Neuroprotective xanthone glycosides from Swertia punicea.
Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1-5 were determined by HRESIMS and NMR spectroscopic methods. Compounds 2, 6, and 7 exhibited potent neuroprotective activity against H(2)O(2)-induced PC12 cell damage.
Du
Xin-Gang
XG
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China.
Wang
Wei
W
Zhang
Shi-Ping
SP
Pu
Xiao-Ping
XP
Zhang
Qing-Ying
QY
Ye
Min
M
Zhao
Yu-Ying
YY
Wang
Bao-Rong
BR
Khan
Ikhlas A
IA
Guo
De-An
DA
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D051381:Rats; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D018696:Neuroprotective Agents; D044004:Xanthones; C552145:puniceaside A; C552146:puniceaside B; D006861:Hydrogen Peroxide