B cell receptor signaling: picky about PI3Ks.
The B cell receptor (BCR) and the pre-BCR control cell fate at many stages of B cell development, survival, and antigen response. Most of these processes require the activation of phosphatidylinositol 3-kinase (PI3K). Previous work has pointed to p110delta as the key catalytic isoform of PI3K for many B cell responses. A study of mice with different combinations of PI3K mutations confirms the central role of p110delta in agonist-mediated signaling, while identifying an unexpected function for the p110alpha isoform in tonic signaling by the pre-BCR and mature BCR.
Limon
Jose J
JJ
Department of Molecular Biology and Biochemistry and Center for Immunology, University of California, Irvine, CA 92697, USA.
Fruman
David A
DA
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D058534:Class I Phosphatidylinositol 3-Kinases; D016654:Genes, RAG-1 / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D009154:Mutation / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell; D019869:Phosphatidylinositol 3-Kinases; C509622:1-phosphatidylinositol 3-kinase p110 subunit, mouse; D058534:Class I Phosphatidylinositol 3-Kinases