title: [Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus].
abstract: OBJECTIVE
  To study the transformation of Astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus var. mongholicus.
  
  
  METHODS
  The chemical components of pre and post-fermenting were comparatively analyzed by techniques of HPLC, column chromatography and spectral identification. Antioxidant effect of transformational product on vascular endothelial cells was researched.
  
  
  RESULTS
  In fermenting of Astragalus membranaceus, Astragaloside IV was transformed into 6-O-beta-D-glucoside cycloastragenol, which had significant antioxidant effect.
  
  
  CONCLUSIONS
  Biotransformation of Astragaloside IV in Astragalus membranaceus was occurred after bidirectional solid fermenting with Ganoderma lucidum, and the biotransformation could enhance effect.
authors.affiliation: Institute of Medicinal Fungi, Department of Life Science, Nanjing Xiaozhuang University, Nanjing 211171, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ruan
authors.forename: Li-Yang
authors.initials: LY
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhuang
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D027885:Astragalus propinquus / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005285:Fermentation; D032902:Ganoderma; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012502:Sapogenins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry* / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D012502:Sapogenins; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A; C061014:cycloastragenol