title: A serious complication of selected internal radiation therapy: case report and literature review.
abstract: The use of selective internal radiation therapy (SIRT) with SIR-Spheres(R) (Sirtex, Sydney, Australia) is increasingly recognized as a potential therapeutic modality of primary and secondary malignant liver tumors. A number of treatment-related complications have been described despite technical expertise and detailed pretreatment investigations to assess suitability. We describe a case of gastric ulceration from nontargeted deposition of SIR-spheres(R) in the gastric mucosa with life-threatening consequences. This case highlights the need for careful screening and appropriate patient selection, and the need to recognize ulceration from SIRT as a potential complication of treatment. The characteristic endoscopic, radiologic, and histopathologic findings are illustrated and recommendations are reviewed with regard to the current literature.
authors.affiliation: Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, NSW Australia.
authors.forename: Katrin M
authors.initials: KM
authors.lastname: Sjoquist
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.forename: Lourens
authors.initials: L
authors.lastname: Bester
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology; D015021:Yttrium Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D015021:Yttrium Radioisotopes