An approach to noninvasive delivery, biodistribution, and fertility control potential evaluation of the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide in the female.
Under guidance of an external pulsed magnetic field the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide delivered into the rat/rabbit oviduct resulted in oocytes with granulated cytoplasm, zona enlargement, membrane disintegration, and finally loss of viability in 72 hours. Also, the percentage biodistribution of magnetic and electrically conductive particles observed under safe level advocates the use of Cuproferrogel as a potential female fertility control molecule.
Jha
Rakhi
R
School of Medical Science and Technology (SMST), Indian Institute of Technology, Kharagpur, West Bengal, India. jharakhi@rediffmail.com
Jha
Pradeep K
PK
Rana
Suresh V S
SV
Guha
Sujoy K
SK
D000818:Animals; D001682:Biological Availability; D003267:Contraception / Q000009:adverse effects / Q000379:methods*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D003300:Copper / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D004574:Electromagnetic Fields; D005187:Fallopian Tubes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D052203:Ferrosoferric Oxide / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D008299:Maleic Anhydrides / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D008962:Models, Theoretical; D011137:Polystyrenes / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D051381:Rats; D014018:Tissue Distribution
D003271:Contraceptive Agents, Female; C523076:CuFe2O4; D005296:Ferrous Compounds; D005782:Gels; D008299:Maleic Anhydrides; D011137:Polystyrenes; D003300:Copper; C025704:Styromal; D052203:Ferrosoferric Oxide; D004121:Dimethyl Sulfoxide