title: Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions.
abstract: With 2-methyl-1,2,3,4-tetrahydroquinoline-derived phosphoramidite ligand (R,R(a))-L(6), Ir-catalyzed intramolecular C-3 allylic alkylation of indoles has been realized to afford highly enantioenriched spiroindolenine derivatives in 92-98% yields with up to >99/1 dr and 97% ee.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Wu
authors.forename: Hu
authors.initials: H
authors.lastname: He
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Liu
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D007211:Indoles; D013141:Spiro Compounds; D007495:Iridium