Down-regulation of miR-126 expression in colorectal cancer and its clinical significance.
MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-126 in colorectal cancers are unclear. In this study, we compared the expression of miR-126 between colorectal cancer tissues and non-tumor tissues. The expression levels of miR-126 in colorectal cancer tissues were significantly lower than those in non-tumor tissues, and miR-126 overexpression inhibited the growth of colorectal cancer cells. This new information may help to clarify the molecular mechanisms involved in colorectal carcinogenesis and to indicate that miR-126 may be a novel suppressive microRNA and help to differentiate between malignant and normal colorectal tissue.
Li
Xiang-Min
XM
Emergency Department of Xiangya Hospital, Central South University, 410008, Changsha, China. lxm8229@126.com
Wang
Ai-Min
AM
Zhang
Juan
J
Yi
Hong
H
D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009367:Neoplasm Staging; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction
C527111:MIRN126 microRNA, human; D035683:MicroRNAs