Formulation of wax oxybenzone microparticles using a factorial approach.
Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 2⁴ experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5–88.1 μm size range, 17.8–38.9 drug content in mg/100 mg MPs and 33.1–87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance.
Gomaa
Y A
YA
Faculty of Pharmacy, Department of Pharmaceutics, Alexandria University, Khartoum square, Azarita, Alexandria 21521, Egypt. yasmine87ag@yahoo.com
Darwish
I A
IA
Boraei
N A
NA
El-Khordagui
L K
LK
D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004655:Emulsions / Q000737:chemistry / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology*; D014885:Waxes / Q000737:chemistry / Q000494:pharmacology*
D001577:Benzophenones; D004655:Emulsions; D013473:Sunscreening Agents; D014885:Waxes; C005290:oxybenzone