title: Porcine peritoneum as source of biocompatible collagen in mice.
abstract: OBJECTIVE
  To investigate the biocompatibility and biodegradability of a membrane made from porcine peritoneum.
  
  
  METHODS
  The membrane (5x5 mm) was inserted in the subcutaneous tissue on the back of 15 mice, which were killed after 1, 3 and 9 weeks (ISO 10993-6). The cellular components of the inflammatory response and degradation of the membrane were analyzed in hematoxylin-eosin-stained histological sections.
  
  
  RESULTS
  After one week, mononuclear cells were observed inside the membrane. After three weeks, the material was almost completely absorbed. After nine weeks, there was no presence of material and there were signs of tissue remodeling. There was neither a foreign body reaction nor signs of tissue necrosis.
  
  
  CONCLUSIONS
  The collagen membrane derived from porcine peritoneum is biocompatible and bioabsorbable when implanted in the subcutaneous tissue of mice.
authors.affiliation: Program in Dentistry, Dental School, UFF, Rio de Janeiro, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Jardelino
authors.forename: Esther Rieko
authors.initials: ER
authors.lastname: Takamori
authors.forename: Luiz Felipe
authors.initials: LF
authors.lastname: Hermida
authors.forename: Ariel
authors.initials: A
authors.lastname: Lenharo
authors.forename: Igor Iuco
authors.initials: II
authors.lastname: Castro-Silva
authors.forename: Jose Mauro
authors.initials: JM
authors.lastname: Granjeiro
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics*; D003094:Collagen / Q000032:analysis / Q000493:pharmacokinetics*; D048091:Guided Tissue Regeneration / Q000379:methods*; D008422:Materials Testing; D008567:Membranes, Artificial; D051379:Mice; D010537:Peritoneum / Q000737:chemistry; D040521:Subcutaneous Tissue / Q000502:physiology*; D013552:Swine; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D003094:Collagen