title: [A case of intubation granuloma treated with steroid inhalation].
abstract: A 36-year-old woman was given a diagnosis of hemophagocytic syndrome associated with systemic lupus erythematosus, and was treated with high-dose methylprednisolone and etoposide. She needed endotracheal intubation for mechanical ventilation because of respiratory failure. She developed hoarseness and stridor 69 days after extubation. A pedunculated mass under her glottis was observed by the laryngoscopy. Development of a laryngeal granuloma due to long-term contact with the endotracheal tube was considered, although she was continuously given oral prednisolone (22.5 mg/day) even after extubation. She was treated with inhalation of fluticasone propionate and her symptoms, e.g. hoarseness, decreased. Disappearance of the polypoid lesion was seen on day 26. A laryngeal granuloma due to intubation developed, even with the systemic administration of steroids; but it was successfully treated with steroid inhalation.
authors.affiliation: Department of Rheumatology, Infectious Diseases and Laboratory Medicine, Faculty of Medicine, University of Miyazaki.
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Miyauchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nagatomo
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kubo
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Umekita
authors.forename: Shirou
authors.initials: S
authors.lastname: Ueno
authors.forename: Ichirou
authors.initials: I
authors.lastname: Takajou
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kai
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okayama
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage*; D005260:Female; D000068298:Fluticasone; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007818:Laryngeal Diseases / Q000188:drug therapy* / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D011239:Prednisolone / Q000008:administration & dosage; D013256:Steroids / Q000008:administration & dosage*
chemical_list: D000730:Androstadienes; D013256:Steroids; D011239:Prednisolone; D000068298:Fluticasone