Increased mean platelet volume in patients with aortic stenosis.
BACKGROUND
Systemic thromboembolism is a serious complication in patients with aortic stenosis (AS). Previous studies have demonstrated that platelet activation occurs in patients with AS. The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with AS.


METHODS
The study group consisted of 43 patients with AS. An age-, gender-, and body mass index-matched control group consisted of 35 healthy volunteers. All patients and control participants underwent echocardiographic examination. We measured the serum MPV values in patients and control participants.


RESULTS
Mean platelet volume was significantly higher among patients with AS when compared with the control group (8.7 ± 1.0 vs 7.9 ± 0.9 fL, respectively; P = .001).


CONCLUSIONS
We have shown that MPV was significantly elevated in patients with AS compared to control participant.
Varol
Ercan
E
Department of Cardiology, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey. drercanvarol@yahoo.com
Arslan
Akif
A
Yucel
Habil
H
Ozaydin
Mehmet
M
Erdogan
Dogan
D
Dogan
Abdullah
A
D001024:Aortic Valve Stenosis / Q000097:blood* / Q000000981:diagnostic imaging; D001792:Blood Platelets / Q000473:pathology*; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D013923:Thromboembolism / Q000097:blood* / Q000000981:diagnostic imaging