Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents.
A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India. ahmedkamal@iict.res.in
Reddy
J Surendranadha
JS
Ramaiah
M Janaki
MJ
Bharathi
E Vijaya
EV
Dastagiri
D
D
Reddy
M Kashi
MK
Pushpavalli
S N C V L
SN
Pal-Bhadra
Manika
M
D000814:Aniline Compounds / Q000737:chemistry*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011743:Pyrimidines / Q000737:chemistry*
D000814:Aniline Compounds; D011743:Pyrimidines; D001569:Benzodiazepines; C030986:pyrimidine; C023650:aniline