Antifungal properties of methanol extract and its active compounds from Brickellia rosmarinifolia Vent.
A new isocoumarin, 7-hydroxyl-4-methyl isocoumarine (1), together with three known monoterpenes, (3R, 4R, 6S)-3, 6-dihydroxy-1-menthene (2), (+)-(1R, 3S, 4R, 6S)-6-hydroxymenthol (3) and 4-isopropyl-1-methylcyclohex-2-ene-1, 6-diol (4), was isolated from the methanol extract of Brickellia rosmarinifolia. The structures were determined by spectroscopic means. Compounds 1, 2, 3 and 4 showed antifungal activities against Colletotrichum musae and Peronophythora litchii in vitro.
Cao
Yongjun
Y
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Wushan, Guangzhou 510642, People's Republic of China.
Wei
Xiaoyi
X
Xu
Hanhong
H
Tang
Wenwei
W
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D049934:Isocoumarins / Q000737:chemistry / Q000494:pharmacology; D000432:Methanol / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
D000935:Antifungal Agents; D049934:Isocoumarins; D010936:Plant Extracts; D000432:Methanol