Can systemic cytokines predict relapse of inflammatory bowel disease?
OBJECTIVE
To determine the value of systemic cytokines as predictors of relapse in inflammatory bowel disease (IBD).


METHODS
A prospective study with 135 patients in clinical remission for at least 3 months. At enrollment, a venous blood was drawn in order to measure, by an ELISA test, the following cytokines: TNFalpha, TNFalpha-R1 and R2, IL-16, IL-1beta, IL 2, IL-R2, IL-6, IL-10, and IFNgamma. All patients were followed-up for one year.


RESULTS
Sixty-six patients had Crohn's disease (CD) and 69 had ulcerative colitis (UC). Thirty-nine (30%) had a relapse. Forty-four percent were receiving immunomodulatory therapy. No differences were found regarding detection and baseline concentration of the various cytokines between patients with CD and UC, or between patients with or without ongoing use of immunomodulators. The detection and concentration levels of cytokines were not associated with the risk of relapse of IBD.


CONCLUSIONS
Systemic cytokines are of little value to predict IBD relapse.
García-Sánchez
Valle
V
Gastroenterology Unit, Reina University Sofia Hospital, Cordoba, Spain. vallegarciasanchez@gmail.com
González
Raúl
R
Iglesias-Flores
Eva
E
Gisbert
Javier P
JP
Angel-Rey
Jose Manuel
JM
Soto-Escribano
Pilar
P
Gálvez-Calderón
Carmen
C
Reyes-López
Antonio
A
Pérez-Jiménez
Francisco
F
de Dios-Vega
Juan F
JF
Muntané
Jordi
J
Gómez-Camacho
Federico
F
D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence
D016207:Cytokines; D007166:Immunosuppressive Agents