title: Biocompatible novel starch/polyaniline composites: characterization, anti-cytotoxicity and antioxidant activity.
abstract: Starch/polyaniline composites have been synthesized using oxidative polymerization of polyaniline in an aqueous dispersion of starch isolated from Colocasia esculenta corm. Scanning electron micrographs reveals the growth of polyaniline over the surface of the starch granules. DPPH scavenging and haemolysis prevention assay have been performed to estimate the antioxidant activity and cytotoxicity of the composites. Formation of new properties of the composites as compared to starch and poloyaniline was evident from the X-ray diffraction analysis (XRD). Characterization done using UV-Vis, FTIR and DSC analysis provide evidence of composite formation. Composite possesses antioxidant nature which increases with the concentration of polyaniline. The haemolysis prevention activity of these novel composite materials is found to increase as compared to the pure polyaniline with minor compromise in the antioxidant activity. The materials show tremendous potential for biomedical applications.
authors.affiliation: Department of Molecular Biology and Biotechnology, Scientist-2, DBT Nodal Centre, Tezpur University, Tezpur 784 028, Assam, India.
authors.forename: Jyoti Prasad
authors.initials: JP
authors.lastname: Saikia
authors.forename: Somik
authors.initials: S
authors.lastname: Banerjee
authors.forename: Bolin Kumar
authors.initials: BK
authors.lastname: Konwar
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D031060:Colocasia / Q000737:chemistry; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D006041:Goats; D006461:Hemolysis / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry* / Q000648:ultrastructure; D014961:X-Ray Diffraction
chemical_list: D000814:Aniline Compounds; D000975:Antioxidants; D001672:Biocompatible Materials; D001713:Biphenyl Compounds; D010851:Picrates; D011108:Polymers; C416807:polyaniline; D013213:Starch; C004931:1,1-diphenyl-2-picrylhydrazyl