title: Zwitterionic chitosan derivatives for pH-sensitive stealth coating.
abstract: Zwitterionic chitosan, a chitosan derivative with a unique pH-dependent charge profile, was employed to create a stealth coating on the cationic surface of drug carriers. Zwitterionic chitosans were synthesized by amidation of chitosan with succinic anhydride. The succinic anhydride-conjugated chitosan had an isoelectric point, which could be easily tuned from pH 4.9 to 7.1 and showed opposite charges below and above the isoelectric point. The succinic anhydride-conjugated chitosan was able to inhibit the protein adsorption to the cationic surface at physiological pH, compatible with blood components and well tolerated upon intraperitoneal injection. The succinic anhydride-conjugated chitosan has the potential to serve as a coating material to prevent protein adsorption to cationic surfaces, which can be removed in a pH-responsive manner.
authors.affiliation: Department of Industrial and Physical Pharmacy, and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Peisheng
authors.initials: P
authors.lastname: Xu
authors.forename: Gaurav
authors.initials: G
authors.lastname: Bajaj
authors.forename: Tyler
authors.initials: T
authors.lastname: Shugg
authors.forename: William G
authors.initials: WG
authors.lastname: Van Alstine
authors.forename: Yoon
authors.initials: Y
authors.lastname: Yeo
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley; D013387:Succinic Anhydrides / Q000737:chemistry
chemical_list: D000577:Amides; D013387:Succinic Anhydrides; C031801:succinic anhydride; D048271:Chitosan