title: Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
abstract: Previous studies showing the presence of antibodies against tumor-associated antigens in healthy individuals suggest that antibody-dependent cell cytotoxicity (ADCC) might play a role in the development of breast cancer. We hypothesized that functional polymorphisms in fragment c gamma receptor (FcgR) genes were associated with breast cancer risk. We conducted hospital-based case-control studies of patients aged 20-74 years with invasive breast cancer, and matched controls from medical checkup examinees in Nagano, Japan and from cancer-free patients in São Paulo, Brazil. A total of 869 pairs (403 Japanese, 80 Japanese Brazilians and 386 non-Japanese Brazilians) were genotyped for two single nucleotide polymorphisms (SNPs): a histidine (H)/arginine (R) polymorphism at position 131 of FcgRIIa (FcgRIIa H131R) and a valine (V)/phenylalanine (F) polymorphism at position 158 of FcgRIIIa (FcgRIIIa F158V). We found no statistically significant association between either of the two SNPs and breast cancer risk regardless of population. In analyses of the three populations combined, adjusted odds ratio (OR) was 0.93 [95% confidence interval (CI) 0.66-1.32] for women with the R/R versus H/H genotype of the FcgRIIa H131R polymorphism and 1.04 (95% CI 0.69-1.57) for the V/V versus F/F genotype of the FcgRIIIa F158V polymorphism. On combination of the two SNPs, compared to women with both the R/R genotype of the FcgRIIa H131R polymorphism and F/F genotype of the FcgRIIIa F158V polymorphism, the adjusted OR for women with both the H/H and V/V genotype was 0.68 (95% CI 0.37-1.27). In conclusion, our findings suggest that ADCC might not play a major role in the etiology of breast cancer.
authors.affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. moiwasak@ncc.go.jp
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimada
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kasuga
authors.forename: Shiro
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onuma
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishimura
authors.forename: Ritsu
authors.initials: R
authors.lastname: Kusama
authors.forename: Gerson S
authors.initials: GS
authors.lastname: Hamada
authors.forename: Ines N
authors.initials: IN
authors.lastname: Nishimoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Iyeyasu
authors.forename: Juvenal
authors.initials: J
authors.lastname: Motola
authors.forename: Fábio M
authors.initials: FM
authors.lastname: Laginha
authors.forename: Roberto
authors.initials: R
authors.lastname: Anzai
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001938:Brazil / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007564:Japan / Q000208:ethnology; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000378:metabolism; D017452:Receptors, IgG / Q000235:genetics*; D011980:Receptors, Progesterone / Q000378:metabolism; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D044465:White People; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen; D017452:Receptors, IgG; D011980:Receptors, Progesterone