title: [Donor lymphocyte infusions after allogeneic stem cell transplantation: single center clinical experience].
abstract: OBJECTIVE
  Donor lymphocyte infusions (DLI) have proven to be useful for the treatment of relapse after allogenic stem cell transplantation (SCT) and for the conversion of mixed chimerism (MC) into complete chimerism. The objective of the present study is to analyze the results of DLI used in both scenarios in a single centre.
  
  
  METHODS
  Twenty five patients were retrospectively analyzed: DLI was used for relapse treatment in 18 cases and for conversion of mixed chimerism in 7.
  
  
  RESULTS
  Six patients from the first group (35%) showed response in a median of 137 days (23-250). After a median follow-up of 12 months (7 months-8 years), 5 patients remained in complete remission. Additionally, one patient recieved prophylactic DLI with good results. Six of the 7 patients (85%) who received DLI for MC showed response. After a median follow-up of 7 years (6-8), 4 patients (57%) remained in remission.
  
  
  CONCLUSIONS
  In our experience, DLI showed clinical benefit in the management of mixed chimerism, although it was less useful in the management of relapse. Novel strategies should be considered in high risk patients.
authors.affiliation: Servicio de Hematología, Hospital General Universitario Gregorio Marañón, Madrid, España. mkwon.hgugm@salud.madrid.org
authors.forename: Mi
authors.initials: M
authors.lastname: Kwon
authors.forename: David
authors.initials: D
authors.lastname: Serrano
authors.forename: Jorge
authors.initials: J
authors.lastname: Gayoso
authors.forename: Javier
authors.initials: J
authors.lastname: Anguita
authors.forename: Ismael
authors.initials: I
authors.lastname: Buño
authors.forename: José Luis
authors.initials: JL
authors.lastname: Díez-Martín
mesh_terms: D000328:Adult; D006801:Humans; D007938:Leukemia / Q000601:surgery*; D017710:Lymphocyte Transfusion; D008223:Lymphoma / Q000601:surgery*; D008875:Middle Aged; D011182:Postoperative Care; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D014019:Tissue Donors; D055815:Young Adult