[The plasma level of sL-selectin, myeloperoxidase (MPO) and granulocyte-colony stimulating factor (G-CSF) in gynecological cancer patients].
It is known that G-CSF not only stimulates the granulopoiesis but also regulates the functions of mature neutrophils. Indirect evidence of this might be the increase of the activity of granulocyte enzymes participating in phagocytosis and killing tumor cells. The purpose of this investigation was to evaluate in the plasma of breast cancer patients the level of adhesion molecule--sL-selectin, as a measure of maturate granulocyte activity and MPO--enzyme of granulocyte, responsible for the cytotoxicity. Additionally we have investigated the plasma level of G-CSF which can increase in the cancers. We tested 17 patients with I stage endometrial cancer and 19 patients with I stage cervical cancer. Plasma samples were drawn before operation. The control group consisted of 20 healthy women. The plasma levels of sL-selectin, myeloperoxidase and G-CSF were measured using a sensitive sandwich ELISA system. In gynecological cancer patients sL-selectin concentration was decreased, but myeloperoxidase concentration increased in comparison to the control group. G-CSF level in group with endometrial cancer was similar to the control group, but in group with cervical cancer was significantly lower. These results suggest that ability of granulocyte binding to cancer cells is decreased but cytotoxicity is increased, at lack of stimulation by of G-CSF.
Czygier
Małgorzata
M
Zakład Diagnostyki Biochemicznej, Uniwersytetu Medycznego w Białymstoku.
Ławicki
Sławomir
S
Gacuta-Szumarska
Ewa
E
Bedkowska
Ewa
E
Szmitkowski
Maciej
M
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016889:Endometrial Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D009195:Peroxidase / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology
D014408:Biomarkers, Tumor; D019041:L-Selectin; D016179:Granulocyte Colony-Stimulating Factor; D009195:Peroxidase