[A case of ulcerative colitis found in a patient whose parent has Crohn's disease].
Inflammatory bowel diseases (IBD) is heterogeneous, chronic relapsing disorder. Inappropriate and exaggerated immune response for the luminal antigen is known as a main pathogenesis. Genetic, infectious, and environmental factors are responsible for unbalanced immune response, but the definite pathogenesis is still unclear. Genetic factor is the most important role of all. That is based on high concordance rate of identical twins and family history. The incident rate and prevalence of IBD for the Asian population is relatively lower than Western population, and the lack of NOD2 or TLR4 genetic polymorphisms in Korea and Japanese population suggests the difference in genetic background between Asian and Western population. In Korea, the case of familial aggregation of IBD is pretty rare. We report a case of the daughter with ulcerative colitis and her mother with Crohn's disease who have a -159C/T promoter polymorphism of CD14 gene for IBD.
Kwak
Jae Wuk
JW
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Suwon, Korea.
Lee
Kang Moon
KM
Chung
Woo Chul
WC
Paik
Chang Nyol
CN
Chang
U Im
UI
Kim
Jin Dong
JD
Jung
Sung Hoon
SH
Yang
Jin Mo
JM
D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D009035:Mothers; D012150:Polymorphism, Restriction Fragment Length; D014056:Tomography, X-Ray; D055815:Young Adult
D018950:Lipopolysaccharide Receptors; D019804:Mesalamine