title: Renal transplantation in patients with sarcoidosis: a French multicenter study.
abstract: OBJECTIVE
  Sarcoidosis is a multisystem disorder of unknown etiology. The outcome of renal transplantation on patients with sarcoidosis is not well known. A few case reports have described recurrence of sarcoidosis after transplant. Here, we report for the first time results and outcome of renal transplantation in a series of patients with sarcoidosis.
  
  
  METHODS
  Eighteen patients with sarcoidosis who underwent renal transplantation were identified retrospectively in eight French renal transplantation departments. Patient medical charts, demographics, and the outcome of renal transplantation were reviewed.
  
  
  RESULTS
  Initial renal disease was related to sarcoidosis in 10 patients. At the end of the follow-up (median, 42 months), patient and death-censored graft survival were 94.4% and the mean GFR was 60 ml/min per 1.73 m(2). Five patients (27%) experienced recurrence of sarcoidosis including extra-renal involvement in two patients and renal involvement in three patients. Median GFR was lower in the group of patients with renal recurrence compared with that of the entire cohort: 31 ml/min per 1.73 m(2). Recurrence occurred shortly after transplantation (median period, 13 months). Risk factors for recurrence included primary renal disease related to sarcoidosis and a shorter delay between the last episode of sarcoidosis and renal transplantation.
  
  
  CONCLUSIONS
  Our results indicate that renal transplantation may be carried out safely in transplant candidates with sarcoidosis. Recurrence is not rare and is likely to affect graft outcome. These results fully justify a specific clinical and histologic monitoring mainly during the early posttransplant period.
authors.affiliation: Nephrology and Transplantation Department, Henri Mondor Hospital, AP-HP, Institut Francilien de Recherche en Néphrologie et Transplantation and Paris XII University, Créteil, France.
authors.forename: Jessie
authors.initials: J
authors.lastname: Aouizerate
authors.forename: Marie
authors.initials: M
authors.lastname: Matignon
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Eric
authors.initials: E
authors.lastname: Thervet
authors.forename: Christine
authors.initials: C
authors.lastname: Randoux
authors.forename: Bruno
authors.initials: B
authors.lastname: Moulin
authors.forename: Loic
authors.initials: L
authors.lastname: Raffray
authors.forename: Matthias
authors.initials: M
authors.lastname: Buchler
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Villar
authors.forename: Mathieu
authors.initials: M
authors.lastname: Mahevas
authors.forename: Dominique
authors.initials: D
authors.lastname: Desvaux
authors.forename: Karine
authors.initials: K
authors.lastname: Dahan
authors.forename: Carine
authors.initials: C
authors.lastname: Diet
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.forename: Philippe
authors.initials: P
authors.lastname: Lang
authors.forename: Philippe
authors.initials: P
authors.lastname: Grimbert
mesh_terms: D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D005602:France; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012507:Sarcoidosis / Q000150:complications*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents