Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.
Lipid changes with statin treatments vary greatly between individuals for reasons which are largely unknown. This study was performed to examine the genetic determinants of lipid responses to rosuvastatin in Chinese patients. A total of 125 polymorphisms in 61 candidate genes from 386 Chinese patients were analyzed for association with the lipid responses to rosuvastatin 10 mg daily. The polymorphisms most highly associated with the low-density lipoprotein cholesterol (LDL-C) response were 421C>A in the ATP-binding cassette G2 gene (P=9.2×10), followed by 18281G>A (V257M) in the flavin-containing monooxygenase 3 gene (P=0.0002), 1421C>G in the lipoprotein lipase gene (P=0.002), and rs4420638 in the apolipoprotein E/C-I/C-IV/C-II gene cluster (P=0.004). Patients with familial hypercholesterolemia had 2.6% smaller reductions in LDL-C compared with patients without familial hypercholesterolemia. This study identified some genetic determinants of LDL-C response to rosuvastatin in Chinese patients, which need to be replicated in other populations.
Hu
Miao
M
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong SAR.
Lui
Sandra S H
SS
Mak
Valiant W L
VW
Chu
Tanya T W
TT
Lee
Vivian W Y
VW
Poon
Emily W M
EW
Tsui
Teresa K C
TK
Ko
Gary T C
GT
Baum
Larry
L
Tam
Lai-Shan
LS
Li
Edmund K
EK
Tomlinson
Brian
B
D044466:Asian People / Q000235:genetics*; D002681:China; D008078:Cholesterol, LDL / Q000378:metabolism; D005260:Female; D005464:Fluorobenzenes / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011743:Pyrimidines / Q000494:pharmacology*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000494:pharmacology*
D008078:Cholesterol, LDL; D005464:Fluorobenzenes; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium