title: Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall.
abstract: OBJECTIVE
  To verify if the composit poli (2-hydroxyethyl methacrylate)-PolyHEMA/polypropylene mesh implanted in the female rat's abdominal wall could be suitable for the prevention of peritoneal adhesions, and for the evaluation of the tecidual response produced by this biomaterial.
  
  
  METHODS
  Polypropylene meshes (Group PP, n=20) and polypropylene meshes coated with a layer of poli (2-hydroxyethyl methacrylate)-PolyHEMA (Group PH, n=20) were implanted on the abdominal wall of Wistar female rats. Ten animals from each group were submitted to euthanasia at 15 and 30 days of the postoperative period.
  
  
  RESULTS
  The animals from the group PP presented visceral adhesions on the mesh surface, which was not observed in the ones from group PH. At the histopathological examination foreign body response was observed in both groups, whilst there was a greater intensity of inflammatory response in group PH on both moments.
  
  
  CONCLUSIONS
  The poli (2-hydroxyethyl methacrylate) polyHEMA hydrogel associated to polypropylene mesh reduces visceral adhesion formation in rats, although it may be associated to greater inflammatory reaction.
authors.affiliation: Veterinary Surgery, Department of Veterinary Medicin, Universidade Federal de Goiás, Goiânia, GO, Brazil. nmp@vet.ufg.br
authors.forename: Neusa Margarida
authors.initials: NM
authors.lastname: Paulo
authors.forename: Sonia Maria
authors.initials: SM
authors.lastname: Malmonge
authors.forename: Liliana Borges de
authors.initials: LB
authors.lastname: Menezes
authors.forename: Flávia Gontijo de
authors.initials: FG
authors.lastname: Lima
authors.forename: Aline de Moraes
authors.initials: Ade M
authors.lastname: Faria
authors.forename: Mariana Moreira
authors.initials: MM
authors.lastname: Andrasckho
authors.forename: Natalia Menezes
authors.initials: NM
authors.lastname: Moreira
authors.forename: Ingrid Bueno
authors.initials: IB
authors.lastname: Atayde
authors.forename: Marcelo Seixo de Brito e
authors.initials: MS
authors.lastname: Silva
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D020007:Implants, Experimental; D007249:Inflammation / Q000473:pathology; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D010537:Peritoneum / Q000187:drug effects* / Q000473:pathology; D011102:Polyhydroxyethyl Methacrylate / Q000009:adverse effects; D011126:Polypropylenes / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes; D011102:Polyhydroxyethyl Methacrylate