A review of post-translational modifications and subcellular localization of Ets transcription factors: possible connection with cancer and involvement in the hypoxic response.
Post-translational modifications and subcellular localizations modulate transcription factors, generating a code that is deciphered into an activity. We describe our current understanding of these processes for Ets factors, which have recently been recognized for their importance in various biological processes. We present the global picture for the family, and then focus on particular aspects related to cancer and hypoxia. The analysis of Post-translational modification and cellular localization is only beginning to enter the age of "omic," high content, systems biology. Our snap-shots of particularly active fields point to the directions in which new techniques will be needed, in our search for a more complete description of regulatory pathways.
Charlot
Céline
C
Department of Cancer Biology, Institute de Genetique et de Biologie, Moleculaire et Cellulaire, Lille, France.
Dubois-Pot
Hélène
H
Serchov
Tsvetan
T
Tourrette
Yves
Y
Wasylyk
Bohdan
B
D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics / Q000378:metabolism*
D050783:Proto-Oncogene Proteins c-ets