title: [Effects of morphine on pupillary light reflex in monkeys].
abstract: The pupil size of both human and other animals can be affected by light. Many kinds of psychiatrical and psychological disorders, such as drug abuse, associate with abnormal properties of pupillary light reflex. Thus, the properties of pupillary light reflex could serve as an indicator for drug abuse detection. However, the effect of drug abuse on pupillary light reflex is till unclear. To assess the effects of addictive drugs on pupillary light reflex quantificationally, in the present study, we examined the effects of morphine on pupil diameter and pupillary light reflex in rhesus monkeys. By measuring the pupil diameter at different timing points before and after the administration of morphine, we found that morphine administration reduced the diameter of pupil and decreased the constriction rate. Our present results provide an experimental support for applying the properties of pupillary light reflex as a reference in addicts' detection.
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Meng
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Zhang
authors.forename: Nan-Hui
authors.initials: NH
authors.lastname: Chen
authors.forename: Ying-Da
authors.initials: YD
authors.lastname: Miao
authors.forename: Xin-Tian
authors.initials: XT
authors.lastname: Hu
authors.forename: Yuan-Ye
authors.initials: YY
authors.lastname: Ma
mesh_terms: D000818:Animals; D000882:Haplorhini; D006801:Humans; D008027:Light; D009020:Morphine / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects* / Q000502:physiology; D012018:Reflex / Q000187:drug effects*; D012025:Reflex, Pupillary / Q000187:drug effects* / Q000528:radiation effects; D014785:Vision, Ocular
chemical_list: D009020:Morphine