A brief introduction to RNAi and microRNAs in stem cells.
Recently, RNAi, including microRNAs (miRNAs), has become an important tool to investigate the regulatory mechanism of stem cell maintenance and differentiation. In this short chapter, we will give a brief overview of the discovery history, functions, and mechanisms of RNAi and miRNAs. We will also discuss RNAi as a tool to study stem cell function and the potential future practical applications.
Murashov
Alexander K
AK
Department of Physiology, East Carolina University, School of Medicine, Greenville, NC, USA.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D034622:RNA Interference / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
D035683:MicroRNAs