title: Lineage-specific expansion of DNA-binding transcription factor families.
abstract: DNA-binding domains (DBDs) are essential components of sequence-specific transcription factors (TFs). We have investigated the distribution of all known DBDs in more than 500 completely sequenced genomes from the three major superkingdoms (Bacteria, Archaea and Eukaryota) and documented conserved and specific DBD occurrence in diverse taxonomic lineages. By combining DBD occurrence in different species with taxonomic information, we have developed an automatic method for inferring the origins of DBD families and their specific combinations with other protein families in TFs. We found only three out of 131 (2%) DBD families shared by the three superkingdoms.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. varodom@mrc-lmb.cam.ac.uk
authors.forename: Varodom
authors.initials: V
authors.lastname: Charoensawan
authors.forename: Derek
authors.initials: D
authors.lastname: Wilson
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Teichmann
mesh_terms: D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000737:chemistry* / Q000145:classification* / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors; D004247:DNA