Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release.
Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release are fabricated by the combination of template synthesis and ATRP grafting. The release of R-propranolol from the imprinted nanotubes in rats is restricted while the release of pharmacologically active S-enantiomer is greatly promoted.
Yin
Junfa
J
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. jfyin@rcees.ac.cn
Cui
Yue
Y
Yang
Gengliang
G
Wang
Hailin
H
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D054802:Molecular Imprinting / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity; D011433:Propranolol / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D013237:Stereoisomerism; D013379:Substrate Specificity
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011433:Propranolol