Granulocyte colony stimulating factor-induced exacerbation of fungus-related immune restoration inflammatory syndrome: a case of chronic disseminated candidiasis exacerbation.
Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.
Chandesris
Marie-Olivia
MO
Paris Descartes University, Assistance Publique-Hôpitaux de Paris, Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades Hospital, 149 rue de Sèvres, Paris Cedex 15, France. olivia.chandesris@nck.aphp.fr
Kelaidi
Charikleia
C
Méchaï
Frédéric
F
Bougnoux
Marie-Elisabeth
ME
Brousse
Nicole
N
Viard
Jean-Paul
JP
Poirée
Sylvain
S
Lecuit
Marc
M
Hermine
Olivier
O
Lortholary
Olivier
O
D000368:Aged; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D019337:Hematologic Neoplasms / Q000188:drug therapy; D006651:Histocytochemistry; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology*; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008297:Male; D008853:Microscopy; D011860:Radiography, Abdominal; D013154:Spleen / Q000473:pathology; D014057:Tomography, X-Ray Computed
D007155:Immunologic Factors; D016179:Granulocyte Colony-Stimulating Factor