title: Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women.
abstract: OBJECTIVE
  To determine plausible associations between endometriosis and vascular endothelial growth factor gene (VEGF -2578 A/C, -1154 G/A, -634 G/C and 936 C/T), also angiotensin I-converting enzyme gene (ACE -240 A/T and 2350 A/G) single nucleotide polymorphisms (SNPs), as well as their respective haplotypes.
  
  
  METHODS
  PCR-based restriction fragment length polymorphism analysis was used to detect SNPs in VEGF and ACE genes in 150 Estonian women with endometriosis and 199 control subjects.
  
  
  RESULTS
  The CC genotype of the VEGF -2578 A/C SNP was correlated with a decreased risk of endometriosis (OR=0.40, 95% CI 0.20-0.78). Other VEGF and ACE SNPs and haplotypes were not associated with endometriosis.
  
  
  CONCLUSIONS
  This case-control study demonstrated that the VEGF -2578 A/C SNP may influence susceptibility to endometriosis in the Estonian population, while associations between endometriosis and other VEGF and ACE SNPs, as well as the respective haplotypes are unlikely.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia.
authors.forename: Merit
authors.initials: M
authors.lastname: Lamp
authors.forename: Merli
authors.initials: M
authors.lastname: Saare
authors.forename: Triin
authors.initials: T
authors.lastname: Laisk
authors.forename: Helle
authors.initials: H
authors.lastname: Karro
authors.forename: Ulle
authors.initials: U
authors.lastname: Kadastik
authors.forename: Andres
authors.initials: A
authors.lastname: Metspalu
authors.forename: Maire
authors.initials: M
authors.lastname: Peters
authors.forename: Andres
authors.initials: A
authors.lastname: Salumets
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D004957:Estonia; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D007703:Peptidyl-Dipeptidase A