title: Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin.
abstract: The spread of antimicrobial resistance among members of the Enterobacteriaceae is a significant clinical threat. We report the treatment of pan-resistant Klebsiella pneumoniae bacteraemia with combination tigecycline and colistin in a 49-year-old male and review available therapeutic options. Despite a poor prognosis, the patient recovered, but remains colonized with the pan-resistant isolate.
authors.affiliation: UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
authors.forename: Romney M
authors.initials: RM
authors.lastname: Humphries
authors.affiliation: Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kelesidis
authors.affiliation: UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Dien Bard
authors.affiliation: UCLA Medical Center, Los Angeles, CA, USA.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Ward
authors.affiliation: Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Debika
authors.initials: D
authors.lastname: Bhattacharya
authors.affiliation: UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lewinski
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003091:Colistin / Q000008:administration & dosage*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives*; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline; D003091:Colistin