[Antioxidant status of patients with thyrotoxicosis syndrome treated with the combined regimen containing epifamin].
The work purpose was research of degree of free-radical processes intensity and catalase activity in blood serum of patients with a thyreotoxicosis syndrome at traditional treatment and the combined therapy with epifamin. Patients (n=25) have been divided into 2 groups: the first group of patients--12 persons who are on traditional treatment (antithyreoid drugs, beta-adrenoblockers); the second group--13 persons, are padding to basic therapy received epifamin on 1 tablet (10 mg) 3 times a day 10-15 minutes prior to meal within 7 days. Patients with thyreotoxicosis syndrome had an intensification of free-radical oxidation that was traced at measurement of biochemiluminescence parameters in blood serum. At the combined therapy with epifamin less expressed intensity of free-radical processes, and also increasing of the general antioxidant activity of an organism that did not descend at traditional treatment was observed. At carrying out of standard therapy of thyreotoxicosis syndrome, including application of antithyreoid drugs and beta-adrenoblockers, catalase activity decreased, that unfavorable affected antioxidant potential of an organism. At the combined therapy with epifamin level of catalase activity, on the contrary, increased, that could influence positively on antioxidant protection of an organism.
Popov
S S
SS
Pashkov
A N
AN
Zoloedov
V I
VI
Popova
T N
TN
Rakhmanova
T I
TI
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D013956:Antithyroid Agents / Q000627:therapeutic use; D002374:Catalase / Q000097:blood; D004359:Drug Therapy, Combination; D005609:Free Radicals / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D013971:Thyrotoxicosis / Q000188:drug therapy* / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D013956:Antithyroid Agents; D005609:Free Radicals; D010455:Peptides; C551699:epifamin; D002374:Catalase