Serum adipocyte fatty acid binding proteins and adiponectin in patients with coronary artery disease: the significance of A-FABP/adiponectin ratio.
BACKGROUND
Adipocyte fatty acid binding protein (A-FABP) and adiponectin have been shown to play important roles in atherosclerosis. We investigated serum A-FABP, adiponectin and A-FABP/adiponectin ratio in patients with coronary artery disease (CAD).


METHODS
A total of 340 subjects who underwent coronary angiography (CAG) were classified into CAD group (n=211) and non-CAD group (n=129) according to the CAG. Serum A-FABP and adiponectin concentrations were determined by enzyme-linked immunosorbent assays.


RESULTS
CAD patients tend to have higher A-FABP concentrations than non-CAD subjects, the difference is significant only between female CAD patients and controls [22.8 (18.6-25.7) ng/ml vs 18.1 (15.6-21.8) ng/ml, P=0.008]. Serum A-FABP concentration was independently associated with Gensini scores in female subjects (P=0.018). CAD patients have significant higher serum A-FABP/adiponectin ratio [1.51 ± 0.05 vs 0.89 ± 0.03 ng/μg, P<0.01] than controls in both genders.


CONCLUSIONS
Serum A-FABP is associated with CAD more closely in female than in male. The A-FABP/adiponectin ratio may be a more useful indicator for CAD than A-FABP or adiponectin alone.
Jin
Jing
J
Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha Hunan 410011, PR China.
Peng
Dao-quan
DQ
Yuan
Shu-guang
SG
Zhao
Shui-ping
SP
Ning
Xiao-hui
XH
Wang
Shu-hui
SH
Li
Song-lin
SL
D017667:Adipocytes / Q000737:chemistry*; D052242:Adiponectin / Q000097:blood*; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012737:Sex Factors
D052242:Adiponectin; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins