Armadillo-repeat protein functions: questions for little creatures.
Armadillo (ARM)-repeat proteins form a large family with diverse and fundamental functions in many eukaryotes. ARM-repeat proteins have largely been characterised in multicellular organisms and much is known about how a subset of these proteins function. The structure of ARM-repeats allows proteins containing them to be functionally very versatile. Are the ARM-repeat proteins in 'little creatures' as multifunctional as their better-studied relatives? The time is now right to start analysing ARM-repeat proteins in these new systems to better understand their cell biology. Here, we review recent advances in understanding the many cellular roles of both well-known and novel ARM-repeat proteins.
Tewari
Rita
R
Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.
Bailes
Elizabeth
E
Bunting
Karen A
KA
Coates
Juliet C
JC
D000818:Animals; D051186:Armadillo Domain Proteins / Q000737:chemistry* / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology
D051186:Armadillo Domain Proteins; D009687:Nuclear Proteins