title: Complete clinical response to neoadjuvant chemotherapy in a 54-year-old male with Askin tumor.
abstract: Askin tumor is a tumor of the thoracopulmonary region that most commonly affects children and adolescents. These rare tumors are a form of primitive neuroectodermal tumor and typically carry a poor prognosis. Treatment is multimodal and consists of a combination of neoadjuvant chemotherapy, radical resection, and adjuvant chemo- and radiotherapy or all of the above. Surgery is advocated in most cases. We report a case of Askin tumor in a 54-year-old male who showed rapid and complete response to neoadjuvant chemotherapy. This allowed potentially radical surgery to be avoided. At one-year follow-up he remains disease-free.
authors.affiliation: Department of Surgery, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland. jmulsow@rcsi.ie
authors.forename: J
authors.initials: J
authors.lastname: Mulsow
authors.forename: M
authors.initials: M
authors.lastname: Jeffers
authors.forename: R
authors.initials: R
authors.lastname: McDermott
authors.forename: J
authors.initials: J
authors.lastname: Geraghty
authors.forename: J
authors.initials: J
authors.lastname: Rothwell
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013899:Thoracic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome