Paraaortic lymph node metastasis showed CR to UFT/LV therapy in elderly rectal cancer.
OBJECTIVE
Intravenous chemotherapy with a combination of several drugs is commonly used to treat metastatic colorectal cancer. However, the associated adverse events can be severe. Here we report a rare case of metastatic rectal cancer in an elderly patient who got complete response for metastatic rectal cancer with oral uracil-tegafur plus leucovorin therapy.


METHODS
77-year-old male. An abdominoperineal resection of the rectum was performed, but para-aortic lymph-node metastasis occurred. Uracil-tegafur plus leucovorin therapy was started on postoperative day 48. Each chemotherapy course comprised 400 mg/day uracil-tegafur and 75 mg/day leucovorin administered for 28 days every 35 days.


RESULTS
After 10 courses, abdominal computed tomography indicated that a good partial response had been achieved. The para-aortic lymph-node swelling disappeared after 17 courses, indicating a complete response. During this period, no adverse events were noted. No recurrence had occurred 4 months after the complete response.


CONCLUSIONS
This case demonstrates that uracil-tegafur plus leucovorin therapy can be used safely even in elderly patients, and suggests that it is likely to be effective in treating metastatic colorectal cancer.
Fujii
Shoichi
S
Department of Surgery, Gastroenterological Center, Yokohama City University, 4-57 Urafunecho, Minami-ku, Yokohama 232-0024, Japan. u0970047@urahp.yokohama-cu.ac.jp
Ota
Mitsuyoshi
M
Ichikawa
Yasushi
Y
Yamagishi
Shigeru
S
Osada
Shunichi
S
Suwa
Hirokazu
H
Kunisaki
Chikara
C
Ohki
Shigeo
S
Endo
Itaru
I
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008207:Lymphatic Metastasis; D008297:Male; D011859:Radiography; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
D005641:Tegafur; D014498:Uracil; D002955:Leucovorin