[Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus].
OBJECTIVE
To study the transformation of Astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus var. mongholicus.


METHODS
The chemical components of pre and post-fermenting were comparatively analyzed by techniques of HPLC, column chromatography and spectral identification. Antioxidant effect of transformational product on vascular endothelial cells was researched.


RESULTS
In fermenting of Astragalus membranaceus, Astragaloside IV was transformed into 6-O-beta-D-glucoside cycloastragenol, which had significant antioxidant effect.


CONCLUSIONS
Biotransformation of Astragaloside IV in Astragalus membranaceus was occurred after bidirectional solid fermenting with Ganoderma lucidum, and the biotransformation could enhance effect.
Ruan
Ming
M
Institute of Medicinal Fungi, Department of Life Science, Nanjing Xiaozhuang University, Nanjing 211171, China.
Zhang
Li-Yang
LY
Yu
Bin
B
Chen
Yu-Sheng
YS
Zhuang
Yi
Y
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D027885:Astragalus propinquus / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005285:Fermentation; D032902:Ganoderma; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012502:Sapogenins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry* / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry* / Q000378:metabolism
D000975:Antioxidants; D012502:Sapogenins; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A; C061014:cycloastragenol