title: Clinical significance of serum CA-125 and soluble tumor necrosis factor receptor type I in cervical adenocarcinoma patients.
abstract: OBJECTIVE
  The purpose of this study was to answer the question whether the measurement of the pretreatment tumor markers and cytokine levels would be of clinical use in patients with cervical adenocarcinoma.
  
  
  METHODS
  CA-125, carcinoembryonic antigen (CEA), and squamous cell carcinoma (SCC), as well as interleukin 6 (IL-6), IL-8, vascular endothelial growth factor, IL-1 receptor antagonist, soluble tumor necrosis factor receptor type I (sTNF RI), and sTNF RII, were assessed in the sera of 120 cervical adenocarcinoma patients.
  
  
  RESULTS
  CA-125 presented a better diagnostic sensitivity than did CEA and SCC, whereas the concentration of most cytokines, except for sTNF RII, revealed higher sensitivity, than did the standard tumor markers. The highest sensitivity was found for sTNF RI. The concentrations of the examined parameters were found to be significantly higher in patients with advanced stage (IIB-IV) as compared with patients with I-IIA stage. [Float1]Serum concentration of IL-6 was the only one that differs significantly, depending on the histological grade. During the 3-year follow-up, 25 patients relapsed, and 73 patients were disease-free. Significantly higher pretreatment serum concentrations of the examined parameters (except for SCC and IL-1 receptor antagonist) were found in patients who developed recurrences. Soluble tumor necrosis factor receptor type I and CA-125 were found to present the highest sensitivity, with areas under the receiver operating characteristic curve of 0.833 and 0.809, respectively. As the result of univariate analysis, CA-125, CEA, sTNF RII, IL-6, sTNF RI, and clinical stage were considered factors of poor prognosis. Multivariate analysis has proven that CA-125 and clinical stage were the only significant independent prognostic factors of the disease-free survival.
  
  
  CONCLUSIONS
  CA-125 is an independent prognostic factor for disease-free survival. Our results have also demonstrated that sTNF RI is probably the most useful marker in cervical adenocarcinoma patients, especially in the early stages of disease.
authors.affiliation: Departments of Tumor Markers, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland. bkotowicz@coi.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Kotowicz
authors.forename: Janina
authors.initials: J
authors.lastname: Kaminska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Fuksiewicz
authors.forename: Maria
authors.initials: M
authors.lastname: Kowalska
authors.forename: Joanna
authors.initials: J
authors.lastname: Jonska-Gmyrek
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Gawrychowski
authors.forename: Janusz
authors.initials: J
authors.lastname: Sobotkowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Skrzypczak
authors.forename: Jozef
authors.initials: J
authors.lastname: Starzewski
authors.forename: Mariusz
authors.initials: M
authors.lastname: Bidzinski
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology; D011379:Prognosis; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D047888:Receptors, Tumor Necrosis Factor, Type I