Electrospinning of silk fibroin and collagen for vascular tissue engineering.
Tubular scaffolds of silk fibroin (SF)/collagen (Col) were prepared by electrospinning with the aim to develop a new scaffold for vascular tissue engineering. The effects of the solvent, solution concentration and collagen content on the morphology of the scaffolds were investigated by SEM. FTIR and XRD were used to investigate their structural changes. Although there were morphological and structural differences, the water uptake and the tensile strength of the scaffolds with different collagen content showed no significant difference. This study confirmed the feasibility of the fabrication of SF/Col tubular scaffold by electrospinning from aqueous solution and provided promising tubular scaffold for vascular tissue engineering.
Zhou
Juan
J
Research Center of Material Science, Beijing Institute of Technology, Beijing 100081, China.
Cao
Chuanbao
C
Ma
Xilan
X
Lin
Jing
J
D001807:Blood Vessel Prosthesis; D003094:Collagen / Q000494:pharmacology*; D055664:Electrochemical Techniques / Q000379:methods*; D005349:Fibroins / Q000494:pharmacology*; D055595:Mechanical Phenomena / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014867:Water; D014961:X-Ray Diffraction
D012996:Solutions; D014867:Water; D003094:Collagen; D005349:Fibroins