title: Catalytic regioselective synthesis of structurally diverse indene derivatives from N-benzylic sulfonamides and disubstituted alkynes.
abstract: An unprecedented protocol has been developed for the regioselective synthesis of structurally diverse indene derivatives from readily accessible N-benzylic sulfonamides and disubstituted alkynes through FeCl(3)-catalyzed cleavage of sp(3) carbon-nitrogen bonds to generate benzyl cation intermediates. In the presence of 10 mol % of FeCl(3), a broad range of N-benzylic sulfonamides smoothly react with internal alkynes, alkynylcarbonyl compounds, alkynyl chalcogenides, or alkynyl halides to afford various functionalized indene derivatives with extremely high regioselectivity.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors.forename: Cong-Rong
authors.initials: CR
authors.lastname: Liu
authors.forename: Fu-Lai
authors.initials: FL
authors.lastname: Yang
authors.forename: Yi-Zhou
authors.initials: YZ
authors.lastname: Jin
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Ma
authors.forename: Dao-Juan
authors.initials: DJ
authors.lastname: Cheng
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Tian