title: Unusual "flesh-eating" strain of Escherichia coli.
abstract: We report an exceptional case of life-threatening Escherichia coli-induced necrotizing fasciitis. A combined host-pathogen genetic analysis explained the phenotype: the host displayed a susceptibility to intravascular coagulation, and the strain was capable of producing a necrotic toxin (cytotoxic necrotizing factor 1), showing how E. coli can be a dermonecrotic pathogen.
authors.affiliation: Intensive Care Unit, Cochin University Hospital, 75014 Assistance Publique Hôpitaux de Paris, Paris, France. david.grimaldi@cch.aphp.fr
authors.forename: David
authors.initials: D
authors.lastname: Grimaldi
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: Hélène
authors.initials: H
authors.lastname: Roussel
authors.forename: Benjamin
authors.initials: B
authors.lastname: Zuber
authors.forename: Hélène
authors.initials: H
authors.lastname: Poupet
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Chiche
authors.forename: Claire
authors.initials: C
authors.lastname: Poyart
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Mira
mesh_terms: D000369:Aged, 80 and over; D001427:Bacterial Toxins / Q000096:biosynthesis; D004926:Escherichia coli / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000096:biosynthesis; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007866:Leg / Q000382:microbiology / Q000473:pathology; D008297:Male; D008853:Microscopy
chemical_list: D001427:Bacterial Toxins; D029968:Escherichia coli Proteins; C060296:cytotoxic necrotizing factor type 1