title: Vertebrate Hedgehog signaling: cilia rule.
abstract: The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction. See research article: http://www.biomedcentral.com/1741-7007/8/65.
authors.affiliation: Tumour Biology and Angiogenesis Department, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. christww@gene.com
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Wilson
authors.forename: Didier Y R
authors.initials: DY
authors.lastname: Stainier
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D053823:Hedgehog Proteins; D029961:Zebrafish Proteins