Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.
Takata
Ryo
R
Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Tokyo, Japan.
Akamatsu
Shusuke
S
Kubo
Michiaki
M
Takahashi
Atsushi
A
Hosono
Naoya
N
Kawaguchi
Takahisa
T
Tsunoda
Tatsuhiko
T
Inazawa
Johji
J
Kamatani
Naoyuki
N
Ogawa
Osamu
O
Fujioka
Tomoaki
T
Nakamura
Yusuke
Y
Nakagawa
Hidewaki
H
D044466:Asian People / Q000235:genetics*; D002277:Carcinoma / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002882:Chromosomes, Human, Pair 13; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*