title: [Treatment with imiquimod and surgical excision of a patient with extramammary Paget's disease. Case report].
abstract: Extramammary Paget's disease (EMPD) is a less common cutaneous type of cancer. It presents as erythematous plaques most frequently located in the genital region, perianal skin, and other cutaneous sites rich in apocrine glands, but it also may originate from keratinocytic stem cells. Recently, imiquimod has been used for the management of primary or relapsing extramammary Paget's disease. Complete healing, without recurrence, of extramammary Paget's disease in patients whom were treated topically with 5 % imiquimod cream was observed. We report a 78 year-old patient with scrotal and perianal extramammary Paget's disease treated with imiquimod cream in both lesions and subsequently with surgical excision in scrotum for the management of relapsing disease.
authors.affiliation: Departamento de Dermatología, Hospital Clínica Nova, San Nicolás de los Garza, Nuevo León, México. zulolazaran@hotmail.com
authors.forename: Zulema
authors.initials: Z
authors.lastname: Olazarán-Medrano
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Treviño-González
authors.forename: Julio César
authors.initials: JC
authors.lastname: Salas-Alanís
authors.forename: Jorge Alejandro
authors.initials: JA
authors.lastname: Lemus-Arias
mesh_terms: D000368:Aged; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005834:Genital Neoplasms, Male / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D000077271:Imiquimod; D008297:Male; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000601:surgery*; D012611:Scrotum
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod