Esophageal resection for high-grade dysplasia and intramucosal carcinoma: When and how?
High-grade dysplasia (HGD) and intramucosal carcinoma (IMC) in the setting of Barrett's esophagus have traditionally been treated with esophagectomy. However, with the advent of endoscopic mucosal resection and endoscopic ablative therapies, endoscopic therapy at centers with expertise is now an established treatment of Barrett's-esophagus-related neoplasia, including HGD and IMC. Esophagectomy is today reserved for more selected cases with submucosal invasion, evidence for lymph node metastasis, or unsuccessful endoscopic therapy.
Konda
Vani J A
VJ
Department of Medicine, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, United States. vkonda@medicine.bsd.uchicago.edu
Ferguson
Mark K
MK
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D001471:Barrett Esophagus / Q000473:pathology / Q000601:surgery*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D004947:Esophagus / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008679:Metaplasia; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery; D018579:Patient Selection; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome