Does inflammatory acne result from imbalance in the keratinocyte innate immune response?
Acne is a multifactorial chronic disease affecting around 80% of teenage population. The pathogenesis of acne involves inflammatory reactions and colonization by the Propionibacterium acnes (P. acnes) strain. P. acnes stimulates the keratinocytes involved in the innate immune response, the intensity of which could be influenced either by bacterial intrinsic factors or by endogenous factors of the host.
Grange
Philippe A
PA
Laboratoire de Recherche en Dermatologie, EA 1833, Faculté de Médecine, Université Paris Descartes, 75679 Paris Cedex 14, France.
Weill
Bernard
B
Dupin
Nicolas
N
Batteux
Frédéric
F
D000152:Acne Vulgaris / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D007113:Immunity, Innate; D015603:Keratinocytes / Q000276:immunology*; D008954:Models, Biological; D011425:Propionibacterium acnes / Q000276:immunology* / Q000472:pathogenicity