Significance of measuring S100A12 and sRAGE in the serum of sepsis patients with postoperative acute lung injury.
BACKGROUND
There is a report that S100A12 is useful as an early marker of acute lung injury (ALI). The purpose of this study was to determine whether S100A12 or sRAGE is useful as a marker during the development of ALI in postoperative sepsis patients.


METHODS
The subjects were patients who underwent emergency surgery because of sepsis secondary to perforation of the lower gastrointestinal tract. We conducted a retrospective study comparing 2 groups of patients: a group of 9 patients who developed postoperative ALI, the ALI(+) group, and a group of 8 patients who did not develop postoperative ALI, the ALI(-) group. Their blood S100A12, sRAGE, IFN-gamma, WBC count, and CRP values were measured immediately after surgery and on postoperative day 1 (D1).


RESULTS
The changes in S100A12 showed significantly higher values immediately postoperatively in the ALI(+) group (p < 0.05). The sRAGE values immediately postoperatively were similar, but on D1, they were significantly higher in the ALI(-) group (p < 0.05).


CONCLUSIONS
S100A12 increases in the early stage of development of ALI. sRAGE production increases in patients who do not develop ALI.
Kikkawa
Tomohiro
T
Department of Critical Care Medicine, Iwate Medical University, School of Medicine, Morioka, Japan.
Sato
Nobuhiro
N
Kojika
Masahiro
M
Takahashi
Gaku
G
Aoki
Kiichi
K
Hoshikawa
Koichi
K
Akitomi
Shinji
S
Shozushima
Tatsuyori
T
Suzuki
Kenji
K
Wakabayashi
Go
G
Endo
Shigeatsu
S
D055371:Acute Lung Injury / Q000097:blood* / Q000209:etiology / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D016638:Critical Illness; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications / Q000401:mortality / Q000601:surgery; D011183:Postoperative Complications / Q000097:blood / Q000401:mortality; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012189:Retrospective Studies; D018570:Risk Assessment; D009418:S100 Proteins / Q000097:blood*; D000067616:S100A12 Protein; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000097:blood* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome
D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human