Highly sensitive and selective spectrofluorimetric determination of metoclopramide hydrochloride in pharmaceutical tablets and serum samples using Eu3+ ion doped in sol-gel matrix.
A simple, sensitive and selective spectrofluorimetric method for the determination of Metoclopramide hydrochloride (MCP) is developed. The MCP can remarkably enhances the luminescence intensity of the Eu(3+) ion doped in sol-gel matrix at lambda(ex)=380 nm in DMSO at pH 8.7. The intensity of the emission band of Eu(3+) ion doped in sol-gel matrix increases due to energy transfer from MCP to Eu(3+) in the excited state. The enhancement of the emission band of Eu(3+) ion doped in sol-gel matrix at 617 nm was found to be directly proportional to the concentration of MCP with a dynamic range of 5 x 10(-9) - 1.0 x 10(-6) mol L(-1) and detection limit of 2.2 x10(-11) mol L(-1).
Attia
M S
MS
Department of Chemistry and Photoenergy Center, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt. mohamed_sam@yahoo.com
Aboaly
M M
MM
D000042:Absorption; D018492:Dopamine Antagonists / Q000032:analysis* / Q000097:blood; D004735:Energy Transfer; D005063:Europium / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008787:Metoclopramide / Q000032:analysis* / Q000097:blood; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013607:Tablets
D018492:Dopamine Antagonists; D008024:Ligands; D004364:Pharmaceutical Preparations; D012997:Solvents; D013607:Tablets; D005063:Europium; D008787:Metoclopramide