[Suitable oxygen concentration for rat model's hypoxic preconditioning].
OBJECTIVE
To study the suitable oxygen concentration in hypoxic preconditioning.


METHODS
Short-term and long-term intermittent hypoxia modes were designed and the effects of various oxygen concentrations on body weight, blood oxygen saturation, swimming capability were analyzed.


RESULTS
The rate of body weight gain in rat model decreased gradually when exposed to hypoxia environment for long time. When the concentration of oxygen changed from 15% to 8%, accompanied with the decreasing of oxygen concentration, a platform was observed in blood oxygen saturation of rat model after hypoxic preconditioning training. Rat swimming capability improved significantly. After trained in 10% hypoxia environment, the swimming capability of kunming mice improved obviously.


CONCLUSIONS
Proper level of hypoxic preconditioning training could improve hypoxia tolerance and enhance the rat sport capability significantly. 15%-10% oxygen concentration range could be regarded as a helpful effective area for hypoxic preconditioning, 10% oxygen concentration might be the eligible concentration for hypoxic preconditioning training.
Hu
Ding-yu
DY
School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China.
Li
Bo
B
Dai
Rong-ji
RJ
Geng
Li-na
LN
Deng
Yu-lin
YL
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D000860:Hypoxia / Q000503:physiopathology*; D019194:Ischemic Preconditioning; D008297:Male; D010100:Oxygen / Q000032:analysis* / Q000378:metabolism; D010807:Physical Endurance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D010100:Oxygen