Studies of histogenetic and neurodegenerative processes in the nervous system using heterotopic neurotransplantation.
The aim of the present article is to summarize our own experimental and published data on neurotransplantation into ectopic sites such as peripheral nerves (mainly) and the anterior chamber of the eye in rats. The review addresses questions touching on the following problems: the histogenesis and survival of nervous tissue after transplantation, the interaction between transplanted tissues with recipient tissues, assessment of long-term living transplants, simultaneous transplantation of different embryonic rudiments, transplantation of spinal cord ganglia, and the effects of trophic factors on the development of transplants. New data on stem cell transplantation into peripheral nerves are discussed.
Petrova
E S
ES
Department of General and Specific Morphology, Research Institute of Experimental Medicine, North West Branch, Russian Academy of Medical Sciences, St. Petersburg, Russia.
D000818:Animals; D016380:Brain Tissue Transplantation; D016923:Cell Death; D002454:Cell Differentiation; D049109:Cell Proliferation; D004622:Embryo, Mammalian; D016332:Fetal Tissue Transplantation; D009410:Nerve Degeneration / Q000473:pathology; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010525:Peripheral Nerves / Q000166:cytology; D051381:Rats; D013116:Spinal Cord / Q000637:transplantation*; D033581:Stem Cell Transplantation