title: [New progress of related research of bone tissue engineering].
abstract: OBJECTIVE
  To review new progress of related research of bone tissue engineering in recent years.
  
  
  METHODS
  Domestic and international literature concerning bone tissue engineering was reviewed and analyzed.
  
  
  RESULTS
  In the recent years, great progression had been made in the research and development of bone tissue engineering, it had been used in more and more hospitals, and relevant national regulations and protocols had been set up. As to seed cells of bone tissue engineering, autologous and allogeneic stem cells had been widely used, while recently embryonic stem cells and induced pluri potent stem cells had attracted most attentions. In the field of scaffolds materials, significant improvements had been made, from natural extractions to artificial polymers; from single construction to multiple compounds with surface modifications. As to the methods of construction, the static seeding approach had been widely accepted, and the applications of bioreactor had provided a stable and various micro-environment for the vitro-culture of different stem cells, which had been regarded as an alternative way of vitro-culture and construction for bone tissue engineering.
  
  
  CONCLUSIONS
  With the tremendous help of the techniques and approaches above, we shall expect a promising future of a new generation bone tissue engineering based medical products in the years to come.
authors.affiliation: Tissue Engineering Research and Development Institute of the Third Military Medical University, Department of Orthopedics, Military Orthopedic Center of PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, PR China. xjzslw@163.com
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Xu
mesh_terms: D019149:Bioreactors; D001842:Bone and Bones; D018929:Cell Culture Techniques; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering