Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells.
Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue-regenerating stem cells in the adult organ? 2. Can tissue-regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor-propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer.
Goldstein
Andrew S
AS
Molecular Biology Institute, University of California, Los Angeles, CA 90095-1662, USA.
Stoyanova
Tanya
T
Witte
Owen N
ON
D000328:Adult; D002454:Cell Differentiation; D006801:Humans; D008297:Male; D011467:Prostate / Q000166:cytology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology