Warfarin-induced skin necrosis mimicking calciphylaxis: a case report and review of the literature.
Warfarin-induced skin necrosis (WISN) and calciphylaxis share similar early clinical findings and can both lead to significant morbidity and mortality. The authors reviewed the literature on both conditions and describe a case of extensive skin necrosis in a patient with end-stage renal disease who was initially suspected to have calciphylaxis. Further investigation supported a diagnosis of WISN. The pathogenesis, clinical manifestations and treatment of WISN and calciphylaxis are discussed, with emphasis on a diagnostic approach for early recognition.
Chacon
Gina
G
Division of Internal Medicine, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA. chacongina@yahoo.com
Nguyen
Timmy
T
Khan
Akram
A
Sinha
Animesh
A
Maddirala
Supriya
S
D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D002114:Calcinosis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D014859:Warfarin / Q000009:adverse effects*
D000925:Anticoagulants; D014859:Warfarin