title: Bipolar disorder and polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1).
abstract: Glutathione S-transferases are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. The present case-control study was performed in Shiraz, Iran to investigate the association between polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and susceptibility to bipolar disorder (BPD). A total of 228 BPD patients participated in the study. In addition, 236 healthy blood donors, who frequency matched with the patients according to age and gender, were also studied as a control group. Statistical analysis revealed that polymorphisms of neither GSTM1 (OR=0.73, 95% CI: 0.50-1.05) nor GSTT1 (OR=0.98, 95% CI: 0.65-1.47) were associated with risk of BPD. Patients were stratified according to their age of onset into early onset (below 19 years old) and late onset (more than 19 years old) groups. Among the early onset group, the GSTM1 null genotype decreases the risk of BPD (OR=0.43, 95% CI: 0.24-0.79). Further analysis showed that a combination of "GSTM1 positive genotype and GSTT1 null genotype" versus "positive genotypes of GSTM1 and GSTT1" increased the risk of BPD (OR=2.28, 95% CI: 1.07-4.85). However, there was no significant association between the study polymorphisms and risk of BPD among the late onset group. The present finding indicated that GSTM1 and GSTT1 are candidate polymorphisms for susceptibility to BDP among adolescents.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Mohammadynejad
authors.forename: Iraj
authors.initials: I
authors.lastname: Saadat
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ghanizadeh
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1