Fission yeast telomeres forecast the end of the crisis.
Recent years have placed fission yeast at the forefront of telomere research, as this organism combines a high level of conservation with human telomeres and precise genetic manipulability. Here we highlight some of the latest knowledge of fission yeast telomere maintenance and dysfunction, and illustrate how principles arising from fission yeast research are raising novel questions about telomere plasticity and function in all eukaryotes.
Dehé
Pierre-Marie
PM
Telomere Biology Laboratory, Cancer Research UK, London, United Kingdom.
Cooper
Julia Promisel
JP
D001260:Ataxia Telangiectasia / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006570:Heterochromatin / Q000235:genetics; D006801:Humans; D008540:Meiosis / Q000235:genetics; D012313:RNA / Q000235:genetics; D012331:RNA, Fungal / Q000235:genetics; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000235:genetics*; D019098:Telomerase / Q000235:genetics; D016615:Telomere / Q000235:genetics* / Q000502:physiology*
D004268:DNA-Binding Proteins; D006570:Heterochromatin; D012331:RNA, Fungal; D012313:RNA; D019098:Telomerase