Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?
Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2beta. In the present study, we investigated TFAP-2beta protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2beta levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption. Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats.
Oreland
S
S
Division of Pharmacology, Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.
Daoura
L
L
Gustafsson-Ericson
L
L
Damberg
M
M
Hyytiä
P
P
Oreland
L
L
Nylander
Ingrid
I
D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008426:Maternal Deprivation; D051381:Rats; D017208:Rats, Wistar; D012931:Social Environment; D050656:Transcription Factor AP-2 / Q000235:genetics / Q000378:metabolism*
D050656:Transcription Factor AP-2; D000431:Ethanol