Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information.
Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotype-specific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.
Zaidi
Sayyed K
SK
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Young
Daniel W
DW
Montecino
Martin
M
Lian
Jane B
JB
Stein
Janet L
JL
van Wijnen
Andre J
AJ
Stein
Gary S
GS
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000378:metabolism; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000235:genetics* / Q000378:metabolism; D008938:Mitosis / Q000235:genetics; D008957:Models, Genetic; D046912:Multiprotein Complexes / Q000378:metabolism; D010641:Phenotype; D011499:Protein Processing, Post-Translational; D022661:RNA, Untranslated / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; D006657:Histones; D046912:Multiprotein Complexes; D022661:RNA, Untranslated; D014157:Transcription Factors; C108312:condensin complexes; D000251:Adenosine Triphosphatases