Anxiolytic-like effect of the monoterpene 1,4-cineole in mice.
Recent studies have shown that some monoterpenes exert anxiolytic- and depressant-like actions, however, these effects from monoterpene 1,4-cineole are still unknown. This work aimed to study the effects of 1,4-cineole in classic animal models for depression- and anxiety-like behavior, specifically the elevated plus maze (EPM), hole board, open field, pentobarbital sleeping time, forced swimming, tail suspension and rota rod tests. 1,4-Cineole was administered orally to mice (100, 200 and 400 mg/kg), while diazepam (1 or 2 mg/kg) and imipramine (10 or 30 mg/kg) were used as standard drugs. 1,4-Cineole (400 mg/kg) modified all parameters observed in the EPM, while no significant variation was observed on general motor activity in the open-field test. In the hole-board assay, 1,4-cineole induced increase on the number of head dips. Forced swimming and tail suspension tests showed that cineole (200 and/or 400 mg/kg) was able to promote significant increase on the immobility time, while a decreased sleep latency was observed (200 and 400 mg/kg ) on the pentobarbital sleeping time. Cineole had no effect on the motor coordination of animals in the rota rod test. The results suggest that 1,4-cineole presents potential anxiolytic-like action consistent with possible general depression of the CNS.
Gomes
Patrícia Bezerra
PB
Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, 60430-270 Fortaleza, Ceará, Brazil.
Feitosa
Mariana Lima
ML
Silva
Maria Izabel Gomes
MI
Noronha
Emmanuelle Coelho
EC
Moura
Brinell Arcanjo
BA
Venâncio
Edith Teles
ET
Rios
Emiliano Ricardo Vasconcelos
ER
de Sousa
Damião Pergentino
DP
de Vasconcelos
Silvânia Maria Mendes
SM
Fonteles
Marta Maria de França
MM
de Sousa
Francisca Cléa Florenço
FC
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D000081005:Cyclohexane Monoterpenes; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; C058951:1,4-cineole