title: The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings.
abstract: Clostridium difficile infection (CDI) is a leading cause of nosocomial infections, with disease severity ranging from mild diarrhea to fulminant colitis. The incidence and severity of CDI has been on the rise over the last 10-20 years, with CDI being increasingly described outside healthcare settings and in populations previously thought to be at low risk. There has also been an increase in the morbidity, mortality and economic burden associated with CDI in the last several years. This increasing incidence and severity is thought to be at least partially due to frequent antibiotic use and the emergence of a hypervirulent C. difficile strain.
authors.affiliation: Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Sahil
authors.initials: S
authors.lastname: Khanna
authors.forename: Darrell S
authors.initials: DS
authors.lastname: Pardi
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D016360:Clostridioides difficile / Q000472:pathogenicity*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000382:microbiology; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D015994:Incidence; D007297:Inpatients; D010045:Outpatients; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents