Extramammary Paget's disease with the appearance of a nodule: a case report.
BACKGROUND
Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease.


METHODS
We here report a case of primary EMPD with the appearance of a nodule on the background of erythema. Histological assessment showed Paget cell infiltration throughout the epidermis with dermal spread. Using immunohistochemistry, the expressions of CK7, CK19, CK20, GCDFP-15, CEA, S-100 protein and bcl-2 were examined to elucidate the cellular differentiation of the carcinoma.


CONCLUSIONS
According to the histological assessment, this case was diagnosed as primary EMPD with carcinoma cells invading into the dermis, but without lymph node infiltration.
Wang
Xia
X
Department of Dermatology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, P. R. China. wenliny@21cn.com
Yang
Wenlin
W
Yang
Jian
J
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D004817:Epidermis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D014845:Vulvar Diseases / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor