The role of adipose tissue and adipokines in obesity-related inflammatory diseases.
Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.
Balistreri
Carmela Rita
CR
Immunosenescence Group, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Corso Tukory 211, 90134 Palermo, Italy.
Caruso
Calogero
C
Candore
Giuseppina
G
D054392:Adipokines / Q000276:immunology*; D000273:Adipose Tissue / Q000276:immunology*; D000375:Aging / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000276:immunology* / Q000628:therapy; D009765:Obesity / Q000150:complications* / Q000209:etiology / Q000276:immunology*; D044343:Overnutrition / Q000150:complications
D054392:Adipokines