[Clinical value of serum TPS, CEA, Pro-GRP and CYFRA21-1 in patients with lung cancer].
OBJECTIVE
Serum tumor markers play important roles in diagnosis, response and prognosis monitoring for lung cancer. The clinical significance of serum level of tissue polypeptide specific antigen (TPS) was investigated in diagnosis, response monitoring and prognosis in patients with lung cancer, compared with carcinoembryonic antigen (CEA), precursor of gastrin-releasing peptide (Pro-GRP) and cytokeratin-19-fragments (CYFRA21-1).


METHODS
Blood samples of eighty-two patients with lung cancer before treatment and some after chemotherapy were measured by ELISA for four tumor markers.


RESULTS
Compared with lung benign diseases group and health control group, the positive rates and levels of TPS, CEA and Pro-GRP in patients with lung cancer were higher, with statistically significant difference. TPS in extensive-small cell lung cancer was significant higher than that in limited-small cell lung cancer. The positive rates and levels of TPS, CEA and Pro-GRP in patients after treatment had significant decreases compared with before treatment. TPS was an independent prognostic factor of non-small cell lung cancer.


CONCLUSIONS
TPS is valuable to diagnosis, response monitoring for patients with lung cancer, moreover, it maybe a useful factor of prognosis of non-small cell lung cancer.
Wang
Jinghui
J
Department of Medical Oncology, Beijing Chest Hospital, Beijing 101149, China.
Shi
Guangli
G
Zhang
Shucai
S
Wang
Qunhui
Q
Yang
Xinjie
X
Li
Xi
X
Wang
Haiyong
H
Zhang
Hui
H
Song
Changxing
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053539:Keratin-19 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D010455:Peptides; D011498:Protein Precursors; C102012:antigen CYFRA21.1; C047897:gastrin-releasing peptide precursor; C089984:tissue polypeptide specific antigen