Collaboration and competition between DNA double-strand break repair pathways.
DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanisms for their efficient repair. The two major pathways involved in the repair of double-strand breaks in eukaryotic cells are non-homologous end joining and homologous recombination. Numerous factors affect the decision to repair a double-strand break via these pathways, and accumulating evidence suggests these major repair pathways both cooperate and compete with each other at double-strand break sites to facilitate efficient repair and promote genomic integrity.
Kass
Elizabeth M
EM
Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Jasin
Maria
M
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics; D017124:Conserved Sequence; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics; D005199:Fanconi Anemia / Q000235:genetics; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D009154:Mutation; D011995:Recombination, Genetic / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics