[Cancer genetic predisposition: current events and perspectives in 2010].
Studies performed during these last 30 years have had a major impact on the understanding of carcinogenesis. They have opened a new field: cancer genetic predisposition. At the present time, most of the cancer predispositions linked to the alteration of one gene, associated with a high risk of cancer and with a specific phenotype have been identified. About 70 genes have been identified and have led to genetic testing. The indication of genetic testing, the management of at risk patients require the establishment of guidelines. The next challenge is the identification of cancer susceptibility genes associated with low risk or modifying the effect of treatment.
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Unité Inserm U830, Service de Génétique, Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 5, France. dominique.stoppa-lyonnet@curie.net
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D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005544:Forecasting; D052138:Genes, Neoplasm; D016147:Genes, Tumor Suppressor; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D009857:Oncogenes; D012306:Risk