title: Sorafenib in metastatic renal cell carcinoma with sarcomatoid differentiation.
abstract: Targeted therapy in the management of metastatic renal cell cancer has been recently introduced to urology practice. The drugs used for management are used in a very limited number of patients and only for clear cell histology. We present a case where we administered sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, to a patient with metastatic renal cell carcinoma of clear cell histology. We found that our results were different from those of previously reported studies, because sarcomatoid differentiation was evident in a histological examination of this case. There was an excellent response to sorafenib. This case report might provide evidence that antiangiogenic agents may be active in any histological type of renal cell carcinoma. However, there are no available data to demonstrate the duration of response and survival benefit.
authors.affiliation: Department of Urology, School of Medicine, Celal Bayar University, School of Medicine, Uncubozköy Mevkii, Kat 8, Manisa, Turkey. lekili@superonline.com
authors.forename: Murat
authors.initials: M
authors.lastname: Lekili
authors.forename: Talha
authors.initials: T
authors.lastname: Muezzinoglu
authors.forename: Nalan
authors.initials: N
authors.lastname: Nese
authors.forename: Gokhan
authors.initials: G
authors.lastname: Temeltas
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D011725:Pyridines / Q000627:therapeutic use*; D012509:Sarcoma / Q000473:pathology*; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib