title: Evaluation of health-related quality of life in patients with breast cancer.
abstract: BACKGROUND
  Breast cancer is the most common cancer among women, comprising about 23% of all cancer types. About 1300 new cases of breast cancer are registered in Lithuania annually. During the last decade, health-related quality of life has become an important part of breast cancer treatment. Pain, fatigue, and sleep disorders are important aspects of health-related quality of life. The aim of the study was to evaluate health-related quality of life (HRQL) among patients with breast cancer in Lithuania. The main tasks were to analyze HRQL in sociodemographic and clinical aspects, and to determine symptoms that have the greatest impact on HRQL .
  
  
  METHODS
  A cross-sectional study was carried out in four major Lithuanian hospitals. An EORTC QLQ-C30 (version 3) questionnaire with general demographic and medical information was distributed among 318 patients. A total of 284 patients were included in the analysis.
  
  
  RESULTS
  The response rate was 89%. The mean age of patients was 55.9 years (SD, 10.1 years), and the mean time from diagnosis--2.36 years (SD, 3.2 years). A greater part (65%) of the studied women lived in a family or with a partner. Women reported high level of functioning across several standardized HRQOL scales: cognitive functioning, everyday activity, and physical functioning. Fatigue and sleeping disorders were the most commonly indicated symptoms in the symptom scale. Fatigue and pain were the most important factors affecting general HRQOL.
  
  
  CONCLUSIONS
  Our results emphasize that the general HRQOL of the studied women is fair, but poorer than that of the corresponding population in other countries. Women living in a family or partnership experienced fewer financial troubles and had higher HRQOL scores across several standardized measures compared to those who were single. Women with late stages of breast cancer felt worse and were less socially active compared to women who were diagnosed with early-stage breast cancer.
authors.affiliation: Department of Preventive Medicine, Kaunas University of Medicine, Eiveniu 4, 50161 Kaunas, Lithuania. rugile.ivanauskiene@med.kmu.lt
authors.forename: Rugile
authors.initials: R
authors.lastname: Ivanauskiene
authors.forename: Rima
authors.initials: R
authors.lastname: Kregzdyte
authors.forename: Zilvinas
authors.initials: Z
authors.lastname: Padaiga
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000191:economics / Q000473:pathology / Q000523:psychology; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005190:Family; D005260:Female; D006304:Health Status; D006801:Humans; D008097:Lithuania; D017533:Marital Status; D008875:Middle Aged; D009367:Neoplasm Staging; D016011:Normal Distribution; D011594:Psychometrics; D011788:Quality of Life; D012042:Registries; D012959:Socioeconomic Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires