Labeling of nucleosides with fluorescent 6-chloro-2,3-napthalimide.
The synthesis and fluorescence properties of new highly fluorescent nucleosides are reported. 6-Chloro-2,3-napthalimides activated with benzotriazole and chlorine label nucleosides quickly and efficiently in yields of 70-82%: the products exhibit quantum efficiencies of 10-94% in solvents of diverse polarity.
Katritzky
A R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Ozcan
S
S
Todadze
E
E
D005456:Fluorescent Dyes / Q000737:chemistry*; D053644:Naphthalimides / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D005456:Fluorescent Dyes; D053644:Naphthalimides; D009705:Nucleosides