The promise and realities of comparative effectiveness research.
Comparative Effectiveness Research (CER) has been given a broad and ambitious mandate. Will it be able to deliver the multifaceted and granular comparative information that it has been tasked with developing? After a discussion of the general conditions for the feasibility of CER, we focus our attention on one of the most challenging areas: the evaluation of diagnostic tests and biomarkers.
Gatsonis
Constantine
C
Center for Statistical Sciences, Brown University, Box G-S121, Providence, RI 02912, USA. gatsonis@stat.brown.edu
D057171:American Recovery and Reinvestment Act; D057186:Comparative Effectiveness Research / Q000331:legislation & jurisprudence / Q000379:methods* / Q000592:standards; D003657:Decision Making; D015340:Epidemiologic Research Design; D019317:Evidence-Based Medicine / Q000331:legislation & jurisprudence / Q000379:methods / Q000592:standards; D006291:Health Policy; D006801:Humans; D010043:Outcome and Process Assessment, Health Care / Q000191:economics / Q000331:legislation & jurisprudence / Q000592:standards*; D014481:United States