title: The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study.
abstract: OBJECTIVE
  Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life.
  
  
  METHODS
  Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke.
  
  
  RESULTS
  Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4-1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6-0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6-0.96) when predicting CRDS.
  
  
  CONCLUSIONS
  In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.
authors.affiliation: Department of Psychiatry, Nijmegen Centre for Evidence-Based Practice, Radboud University Nijmegen Medical Centre, The Netherlands. l.wouts@psy.umcn.nl
authors.forename: L
authors.initials: L
authors.lastname: Wouts
authors.forename: J G
authors.initials: JG
authors.lastname: Janzing
authors.forename: I K
authors.initials: IK
authors.lastname: Lampe
authors.forename: B
authors.initials: B
authors.lastname: Franke
authors.forename: F
authors.initials: F
authors.lastname: de Vegt
authors.forename: I
authors.initials: I
authors.lastname: Tendolkar
authors.forename: M B
authors.initials: MB
authors.lastname: van Iersel
authors.forename: J K
authors.initials: JK
authors.lastname: Buitelaar
authors.forename: R C
authors.initials: RC
authors.lastname: Oude Voshaar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000523:psychology*; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009426:Netherlands; D009497:Neurotic Disorders / Q000523:psychology*; D012307:Risk Factors; D012737:Sex Factors