title: Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209.
abstract: Our goal in the present study was to evaluate whether decabromodiphenyl ether (BDE-209), which is the most abundant polybrominated diphenyl ether (PBDE) found in human samples, affects against target organs. Sprague-Dawley male rats were exposed to vehicle or BDE-209 (100, 300, or 600 mg/kg body weight, daily) from postnatal day (PND) 10 to PND 42. There was no significant difference in body and male reproductive organ weight changes compared with controls. However, liver, thyroid and adrenal gland weights were significantly increased in the high-dose of BDE-209 group. BDE-209 significantly induced the expression of cytochrome P450 (CYP1A2, CYP3A1, and CYP2B1) enzymes in the liver. Furthermore, constitutive androstane receptor (CAR) and pregnane xenobiotic receptor (PXR) expression levels were also increased in a dose-dependent manner. Total serum triiodothyronine (T3) concentration was significantly reduced in a dose-dependent manner, whereas the level of thyroid-stimulating hormone was significantly increased with BDE-209 treatment. In the histological findings, multiple areas of degenerated follicular epithelium and slight attenuation of the follicular epithelium were observed in the thyroid glands by high doses (300 and 600 mg/kg) of BDE-209 treatment. The presence of hepatocytic fatty degeneration and inflammatory foci were also observed in the 300 and 600 mg/kg of BDE-209 group. These findings demonstrate that BDE-209 induces hyperthyroidism and hepatotoxicity. In the future, further research is needed to determine the relationship between target organ toxicity and blood concentrations of BDE-209.
authors.affiliation: College of Pharmacy, Pusan National University, Busan, Korea.
authors.forename: Ena
authors.initials: E
authors.lastname: Lee
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Kim
authors.forename: Jae Seok
authors.initials: JS
authors.lastname: Choi
authors.forename: Patra
authors.initials: P
authors.lastname: Nabanata
authors.forename: Na Young
authors.initials: NY
authors.lastname: Kim
authors.forename: Mee Young
authors.initials: MY
authors.lastname: Ahn
authors.forename: Ki Kyung
authors.initials: KK
authors.lastname: Jung
authors.forename: Il Hyun
authors.initials: IH
authors.lastname: Kang
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Kim
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kwack
authors.forename: Kui Lea
authors.initials: KL
authors.lastname: Park
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Tae Seok
authors.initials: TS
authors.lastname: Kang
authors.forename: Jaewon
authors.initials: J
authors.lastname: Lee
authors.forename: Byung Mu
authors.initials: BM
authors.lastname: Lee
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000818:Animals; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects*
chemical_list: D055768:Halogenated Diphenyl Ethers; C010902:decabromobiphenyl ether