title: Synthesis of novel tetrahydroisoquinoline bronchodilators.
abstract: The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide 71 was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of pulmonary disorders.
authors.affiliation: Respiratorius AB, Magistratsvägen 10, SE 226 43 Lund, Sweden.
authors.forename: Maria F
authors.initials: MF
authors.lastname: Dalence-Guzmán
authors.forename: Jörgen
authors.initials: J
authors.lastname: Toftered
authors.forename: Viveca Thornqvist
authors.initials: VT
authors.lastname: Oltner
authors.forename: David
authors.initials: D
authors.lastname: Wensbo
authors.forename: Martin H
authors.initials: MH
authors.lastname: Johansson
mesh_terms: D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D001993:Bronchodilator Agents; D007546:Isoquinolines