title: [Use of antibiotics in the treatment of ulceronecrotic tonsillitis due to vaccination by tabletted smallpox vaccine].
abstract: Clinical trials of tabletted pox vaccine revealed development of tonsillitis as a postvaccinal reaction in some volunteers: ulceronecrotic lesions in the tonsils, lymphadenitis, hyperthermia and asthenia. The main cause of the local inflammatory reactions was activation of the host opportunistic microflora including hemolytic streptococci and Staphylococcus aureus. For the treatment of the infectious complications systemic antimicrobials, such as benzylpenicillin, amoxicillin, ampicillin, cefazolin and fluoroquinolones (ciprofloxacin) in combination with the symptomatic therapy were used. The treatment course of 9 days provided complete elimination of the postvaccinal reactions, the specific antibody generation being not affected.
authors.forename: V P
authors.initials: VP
authors.lastname: Bondarev
authors.forename: I V
authors.initials: IV
authors.lastname: Borisevich
authors.forename: S A
authors.initials: SA
authors.lastname: Mel'nikov
authors.forename: A V
authors.initials: AV
authors.lastname: Kaskov
authors.forename: E E
authors.initials: EE
authors.lastname: Shagarov
authors.forename: N K
authors.initials: NK
authors.lastname: Chernikova
authors.forename: T V
authors.initials: TV
authors.lastname: Dorokhina
authors.forename: A V
authors.initials: AV
authors.lastname: Rylov
authors.forename: T A
authors.initials: TA
authors.lastname: Bondareva
authors.forename: A I
authors.initials: AI
authors.lastname: Terent'ev
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D006801:Humans; D009336:Necrosis / Q000188:drug therapy / Q000209:etiology; D014066:Palatine Tonsil / Q000187:drug effects / Q000473:pathology; D012900:Smallpox Vaccine / Q000009:adverse effects* / Q000276:immunology; D014069:Tonsillitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014456:Ulcer / Q000188:drug therapy* / Q000209:etiology; D014616:Vaccinia virus / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D012900:Smallpox Vaccine