title: Basilar artery thrombosis: imaging and endovascular therapy.
abstract: OBJECTIVE
  Basilar artery thrombosis represents a rare type of ischaemic stroke with a mortality rate of 80%-90% if not promptly treated. The aim of our study was to review our experience with computed tomography angiography (CTA) in the diagnosis of basilar artery thrombosis and its treatment with endovascular procedures.
  
  
  METHODS
  Our retrospective study is based upon 59 nontrauma patients with episodes of sudden loss of consciousness. Patients were investigated using unenhanced brain CT followed by intracranial CTA (16-slice CT) when no parenchymal haemorrhage was detected. Patients with a CTA diagnosis of basilar artery thrombosis were considered for endovascular treatment. CTA accuracy was evaluated by considering the 12 patients who underwent endovascular angiography (the gold standard). The success of endovascular therapy was evaluated by considering the degree of microcirculatory reperfusion.
  
  
  RESULTS
  After the exclusion of 33 patients affected by parenchymal or subarachnoid haemorrhage, the final study consisted of 26 patients who underwent CTA. Basilar artery thrombosis was diagnosed in 15 of them, and 12 were treated at our institution. The comparison between CTA and endovascular angiography showed 100% agreement in evaluating occlusion site and extension. Seven patients underwent intra-arterial lysis, and five underwent mechanical clot removal.
  
  
  CONCLUSIONS
  CTA, with its wide availability and rapid execution times, is the most indicated examination in the case of suspected basilar artery thrombosis. Although there is a lack of randomised controlled prospective studies suggesting the most appropriate therapeutic approach to basilar artery thrombosis, our study lends weight to the role of interventional neuroradiology in the treatment of this condition.
authors.affiliation: Servizio di Radiologia, Comprensorio Sanitario di Bolzano, Azienda Sanitaria dell'Alto Adige, Via L. Böhler 5, Bolzano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bonatti
authors.forename: F
authors.initials: F
authors.lastname: Ferro
authors.forename: T
authors.initials: T
authors.lastname: Haglmüller
authors.forename: P
authors.initials: P
authors.lastname: Pernter
authors.forename: L
authors.initials: L
authors.lastname: Naibo
mesh_terms: D017130:Angioplasty / Q000379:methods; D001488:Basilar Artery; D002533:Cerebral Angiography / Q000379:methods*; D003287:Contrast Media; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015912:Thrombolytic Therapy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media