CALU A29809G polymorphism in coronary atherothrombosis: Implications for coronary calcification and prognosis.
BACKGROUND
Arterial calcification is a risk factor for atherosclerosis. Calumenin (CALU), a protein regulating proteins involved in coagulation and arterial calcification also has extracellular functions related to atherosclerosis. We recently described that CALU polymorphism A29809G was related to acenocoumarol requirements, and we wanted to evaluate its role in arterial calcification and prognosis.


METHODS
A total of 374 consecutive patients with non-ST-elevation acute coronary syndrome (nSTACS). In 175 of them, who underwent percutaneous coronary intervention, we assessed calcification in each main coronary artery. Follow-up at 1 and 6 months was performed for adverse end-points.


RESULTS
CALU 29809G carriers were more frequent in the low calcium group (P = 0.037). The presence of >or=3 cardiovascular risk factors and CALU polymorphism were associated with arterial calcification (OR 2.34, P = 0.049; and OR 0.34, P = 0.019, respectively). CALU 29809G allele was the only variable associated with events at 1 month (HR 0.42; P = 0.042). Multivariate analysis showed that, at 6 months, age and severe anginal symptoms were associated with worse prognosis (HR 2.13, P = 0.023; and HR 2.01, P = 0.011, respectively), whereas CALU 29809G allele associated with good prognosis (HR 0.59, P = 0.044). Our results suggest that CALU A29809G is associated with arterial calcification and short-term prognosis of the outcome of patients with nSTACS.
Hernández-Romero
Diana
D
Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Ruiz-Nodar
Juan Miguel
JM
Marín
Francisco
F
Tello-Montoliu
Antonio
A
Roldán
Vanessa
V
Mainar
Luis
L
Pérez-Andreu
Virginia
V
Antón
Ana I
AI
Bonaque
Juan C
JC
Valdés
Mariano
M
Vicente
Vicente
V
González-Conejero
Rocío
R
D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011446:Prospective Studies
D015415:Biomarkers; C510527:CALU protein, human; D002135:Calcium-Binding Proteins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain