title: Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU).
  
  
  METHODS
  A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic AAU. The control group included 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases. The level of NGAL was determined with a commercially available ELISA kit.
  
  
  RESULTS
  The concentration of NGAL in aqueous humor was markedly higher in patients with idiopathic AAU than in control subjects (Mann-Whitney U test, p<0.001). The level of NGAL was 139,197.38+/-183,426.36 (mean+/-SD) pg/ml in eyes with AAU and 3,169.96+/-1,595.78 pg/ml in the eyes of the control group.
  
  
  CONCLUSIONS
  The aqueous humor NGAL level is increased in eyes with idiopathic AAU. These results imply that NGAL is associated with the regulation of inflammation in patients with AAU and could be used as a biomarker of ocular inflammation and immunomodulatory treatment response.
authors.affiliation: Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain. david.salom@yahoo.com
authors.forename: David
authors.initials: D
authors.lastname: Salom
authors.forename: Empar
authors.initials: E
authors.lastname: Sanz-Marco
authors.forename: Jose L
authors.initials: JL
authors.lastname: Mullor
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Lopez-Prats
authors.forename: Salvador
authors.initials: S
authors.lastname: Garcia-Delpech
authors.forename: Patricia
authors.initials: P
authors.lastname: Udaondo
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Millan
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Arevalo
authors.forename: Manuel
authors.initials: M
authors.lastname: Diaz-Llopis
mesh_terms: D000208:Acute Disease; D000209:Acute-Phase Proteins / Q000378:metabolism*; D001082:Aqueous Humor / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D014606:Uveitis, Anterior / Q000378:metabolism*
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins