title: Treatment of periodontal defects with enamel matrix derivative: clinical evaluation at early healing stages.
abstract: The aim of this retrospective clinical study was to evaluate the treatment of intrabony periodontal defects with enamel matrix derivative (EMD) during the early stages of healing. Sixteen patients aged 38-77 years with a clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 25 teeth with various osseous defects received regenerative therapy with EMD, and were followed for a minimum of 6 months. Post-operative healing was uneventful in the majority of cases. Treatment of the intrabony defects with EMD led to a statistically significant improvement in the mean value of probing depth at 3 months compared with that at baseline (p<0.001). Mean values of attachment gain at 3 and 6 months were of clinical significance: 3.6+/-1.8mm and 3.2+/-1.5mm, respectively. Reduction in probing depth was achieved with minimal recession of gingival margin and was sustained over a time course of 6 months. A progressive increase in radiopacity, suggestive of initial signs of bone-fill, was observed by 6 months. In summary, the results suggest that treatment of intrabony defect with EMD induces favorable periodontal healing with a high level of predictability.
authors.affiliation: Division of Conservative Dentistry, Department of Clinical Oral Health Science, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan. atsaito@tdc.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Kei
authors.initials: K
authors.lastname: Ota
authors.forename: Koushu
authors.initials: K
authors.lastname: Fujinami
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nikaido
authors.forename: Takemi
authors.initials: T
authors.lastname: Makiishi
mesh_terms: D000134:Acid Etching, Dental; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D055113:Chronic Periodontitis / Q000601:surgery; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D012534:Dental Scaling; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000517:prevention & control; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D011183:Postoperative Complications; D011859:Radiography; D012189:Retrospective Studies; D016745:Root Planing; D013524:Surgical Flaps; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins