title: Antibacterial activity of 5-dialkylaminomethylhydantoins and related compounds.
abstract: To find new antibacterial leads in the class of hydantoin derivatives, we carried out synthetic investigation and biological evaluation of the title hydantoin derivatives and related compounds. Among the hydantoin derivatives described in this article, compound 3o, in which a 2,6-dichlorophenyl ring was introduced at the N-3 position of the hydantoin nucleus, showed the highest levels of antibacterial activity against both Escherichia coli NBRC14237 (NIHJ) and Staphylococcus aureus ATCC6538P (gram-negative and gram-positive bacteria, respectively) strains.
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Fujisaki
authors.forename: Kaori
authors.initials: K
authors.lastname: Shoji
authors.forename: Mari
authors.initials: M
authors.lastname: Shimodouzono
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kashige
authors.forename: Fumio
authors.initials: F
authors.lastname: Miake
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D006827:Hydantoins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D006827:Hydantoins