Cell cycle: deconstructing tension.
Prior to anaphase, sister chromatids must be attached to microtubules and under tension, a condition that satisfies the spindle checkpoint. Removal of sister chromatid cohesion is predicted to cause a fall in tension. Two studies shed light on how cells avoid re-activation of the spindle checkpoint when cohesion is lost.
Musacchio
Andrea
A
Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, Milan, Italy.
D000705:Anaphase; D002842:Chromatids / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*