title: Dynamics of early estradiol production may be associated with outcomes of in vitro fertilization.
abstract: This study investigated the effects of total E(2) production during controlled ovarian stimulation (COS) calculated by "modified area under the curve for E(2) (AUC-E(2))" and of the changes in E(2) level during the initial stimulation period calculated as "slope of initial increase in E(2) (Sl-E(2))" on the outcomes of IVF cycles using GnRH antagonist protocols. The findings suggest that the rate of initial increase in E(2) rather than total E(2) production during COS might affect the competence of retrieved oocytes in GnRH antagonist cycles.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, South Korea.
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Seung-Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jee
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Suh
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D019540:Area Under Curve; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D007700:Kinetics; D008954:Models, Biological; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol