title: [Therapeutic drug monitoring of clonazepam].
abstract: Clonazepam is a 1-4 benzodiazepine mainly used to treat epilepsy and epileptiform convulsion state. Rapidly absorbed after oral administration, it is widely distributed in the organism and is extensively converted in metabolites, poorly or not active, eliminated mainly in urine (70%) and feces. Elimination half-life is long, around 40 h. In adult and child, several studies showed a concentration-effect relation. Meanwhile, a large inter-individual variability in the dose-concentration relation was observed. A 15-50 microg/L range of clonazepam blood concentrations appears to be retained as an acceptable target to control a majority of epileptic seizures. The Therapeutic Drug Monitoring (TDM) of clonazepam can be considered as possibly useful in case of association with CYP450 inducers or inhibitors, suspicion of poor observance, or toxicity signs.
authors.affiliation: Service de Pharmacologie-Toxicologie, CHU Côte de Nacre, Caen, France. debruyne-d@chu-caen.fr
authors.forename: Danièle
authors.initials: D
authors.lastname: Debruyne
authors.forename: Magalie
authors.initials: M
authors.lastname: Pailliet-Loilier
authors.forename: Véronique
authors.initials: V
authors.lastname: Lelong-Boulouard
authors.forename: Antoine
authors.initials: A
authors.lastname: Coquerel
authors.forename: Danièle
authors.initials: D
authors.lastname: Bentué-Ferrer
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002648:Child; D002998:Clonazepam / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans
chemical_list: D000927:Anticonvulsants; D002998:Clonazepam