Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.
BACKGROUND
The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue.


METHODS
One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression.


RESULTS
The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%.


CONCLUSIONS
MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.
Martin
Robert C G
RC
Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA. Robert.martin@louisville.edu
Li
Yan
Y
Liu
Qiahong
Q
Barker
David F
DF
Doll
Mark A
MA
Hein
David W
DW
D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018196:Carcinoma, Adenosquamous / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism
D013482:Superoxide Dismutase