Calix[4]pyrrole-based anion transporters with tuneable transport properties.
Three new bis-1,2,3-triazole strapped calix[4]pyrroles have been prepared via'click' chemistry and their anion complexation and lipid bilayer transport properties studied by a combination of single crystal X-ray diffraction studies, (1)H NMR titration techniques, isothermal titration calorimetry and lipid bilayer anion transport studies in POPC vesicles. Bilayer transport efficiency for transmembrane chloride transport was found to directly depend on the length of the alkyl chain present in the bis-triazole strap.
Yano
Masafumi
M
School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Tong
Christine C
CC
Light
Mark E
ME
Schmidtchen
Franz P
FP
Gale
Philip A
PA
D000838:Anions / Q000378:metabolism*; D047250:Calixarenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D002151:Calorimetry; D018360:Crystallography, X-Ray; D017136:Ion Transport; D008051:Lipid Bilayers / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000378:metabolism*; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D017186:Titrimetry
D000838:Anions; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D011166:Porphyrins; C469811:calix(4)pyrrole; D047250:Calixarenes; C028694:1-palmitoyl-2-oleoylphosphatidylcholine