Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
Behan
Aine T
AT
Department of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. abehan@rcsi.ie
van den Hove
Daniel L A
DL
Mueller
Lynn
L
Jetten
Marlon J A
MJ
Steinbusch
Harry W M
HW
Cotter
David R
DR
Prickaerts
Jos
J
D000818:Animals; D001007:Anxiety / Q000473:pathology; D001522:Behavior, Animal; D003071:Cognition; D003345:Corticosterone / Q000097:blood; D003863:Depression / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D051379:Mice; D019964:Mood Disorders / Q000473:pathology; D009457:Neuroglia / Q000473:pathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012727:Sex Characteristics; D013315:Stress, Psychological
D003345:Corticosterone