Androgen excess down-regulates connexin43 in a human granulosa cell line.
By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.
Wu
Cheng-Hsuan
CH
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
Yang
Jyuer-Ger
JG
Yang
Jiann-Jou
JJ
Lin
Yueh-Min
YM
Tsai
Hong-Der
HD
Lin
Ching-Yuang
CY
Kuo
Pao-Lin
PL
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000728:Androgens / Q000494:pharmacology*; D002460:Cell Line; D018031:Connexin 43 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006107:Granulosa Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000209:etiology / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology
D000728:Androgens; D018031:Connexin 43; C500216:GJA1 protein, human; D015124:8-Bromo Cyclic Adenosine Monophosphate; D013739:Testosterone; C013915:boldenone