title: Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.
abstract: Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.
authors.affiliation: Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA. dvsst@netvision.net.il
authors.forename: Avner
authors.initials: A
authors.lastname: Shahar
authors.forename: Kushang V
authors.initials: KV
authors.lastname: Patel
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Danit R
authors.initials: DR
authors.lastname: Shahar
authors.forename: Louigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000097:blood* / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology*; D012643:Selenium / Q000097:blood*
chemical_list: D012643:Selenium