title: Exercise therapy correlates with improving renal function through modifying lipid metabolism in patients with cardiovascular disease and chronic kidney disease.
abstract: BACKGROUND
  Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) are at high risk of cardiovascular mortality, thus therapies to improve renal function should be clinically investigated.
  
  
  RESULTS
  We divided consecutive patients with CVD and CKD (n=19) into exercise (n=10) and non-exercise (n=9) therapy groups. Exercise therapy for 12 weeks significantly improved the anaerobic metabolic threshold (AT-V O₂) and high-density lipoprotein cholesterol (HDL-C) levels, and reduced triglyceride levels. Exercise therapy also improved estimated glomerular filtration rate (eGFR). Change in eGFR correlated significantly and positively with change in AT-V O₂ and HDL-C, and negatively with change in triglyceride levels.
  
  
  CONCLUSIONS
  Exercise therapy correlates with improving renal function in CVD patients with CKD through modifying lipid metabolism. Exercise therapy could be an effective clinical strategy to improve renal function.
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Life Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Toyama
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Hideki
authors.initials: H
authors.lastname: Oka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sumida
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy*; D008076:Cholesterol, HDL / Q000097:blood; D005081:Exercise Therapy; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides