[Contributions of the ex vivo human perfused placenta in the study of placental transfer of drugs].
Perfused human placental lobule was developed during the 1970s. Only this model respects the anatomical features of the human placenta. This approach allows different technical conditions (concentrations of drugs…) without ethical problems. Limitations of this ex vivo model are detailed in this review, also its recent contributions in better understanding of placental passage of drugs.
Ceccaldi
P-F
PF
Service de gynécologie-obstétrique, hôpital Beaujon, GHU Nord, AP-HP, université Paris-7, 100, boulevard du Général-Leclerc, 92100 Clichy, France. pfceccaldi@gmail.com
Mandelbrot
L
L
Farinotti
R
R
Forestier
F
F
Gil
S
S
D001692:Biological Transport; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D010477:Perfusion; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D004364:Pharmaceutical Preparations