title: [An autopsy case of alpha-fetoprotein-producing carcinoma of the sigmoid colon resulting in sudden death].
abstract: A 63-year-old woman was admitted to our hospital with complaints of abdominal distention and bilateral cervical masses. Her serum AFP was 11700 ng/dl. AFP was confirmed immunohistochemically by biopsy of a sigmoid colon tumor, yielding a diagnosis of AFP-producing carcinoma of the sigmoid colon, accompanied by multiple liver metastases, and systemic multiple lymph node metastases. Due to her poor general condition with mitral regurgitation, the patient began S-1 treatment. The patient's general condition rapidly worsened after 1 course of S-1 had no effect. She died on the 59th hospital day and a pathological autopsy was performed. We examined 67 cases of AFP-producing colon cancer in Japan, including our own, and report the findings with references.
authors.affiliation: Department of Surgery, Tokyo Rinkai Hospital. asakage-n@tokyorinkai.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Asakage
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Haraguchi
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Yamasaki
mesh_terms: D003645:Death, Sudden; D005260:Female; D006801:Humans; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000378:metabolism / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins