Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells.
One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-beta-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.
Ding
Yan
Y
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Liang
Chun
C
Yang
Seo Young
SY
Ra
Jeong Chan
JC
Choi
Eun Mi
EM
Kim
Jeong-Ah
JA
Kim
Young Ho
YH
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003094:Collagen / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects* / Q000201:enzymology; D010024:Osteoporosis / Q000517:prevention & control; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
D010636:Phenols; D010936:Plant Extracts; D003094:Collagen; D000469:Alkaline Phosphatase; D002118:Calcium