title: Total knee replacement in patients with end-stage haemophilic arthropathy: 25-year results.
abstract: Haemophilia is an x-linked inherited bleeding disorder which can cause severe arthropathy. We have reviewed the results of 70 primary total knee replacements (TKR) performed in 57 haemophilic patients between 1983 and 2007. The functional results were assessed using the Hospital for Special Surgery (HSS) knee scoring system and Kaplan-Meier survivorship analysis. Six patients died. HSS scores were available for 60 TKRs at a mean follow-up of 9.2 years (2 to 23); 57 (95%) had good or excellent results. Deep infection was recorded in one patient. Kaplan-Meier analysis using infection and aseptic loosening as endpoints showed the survival rate at 20 years to be 94.0%. A reduction in infection, spontaneous haemarthrosis and improvement in the quality of life were noted to justify surgery in our series of patients with a mean age of 43 (25 to 70). We have found that using the latest techniques of continuous infusion of clotting Factor have significantly helped to reduce the complication rates and have achieved results which match those of the non-haemophilic population undergoing TKR.
authors.affiliation: Department of Trauma and Orthopedics, The Royal Free Hospital, Pond Street, London NW3 2PS, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Goddard
authors.forename: H A
authors.initials: HA
authors.lastname: Mann
authors.forename: C A
authors.initials: CA
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D003029:Coagulants / Q000627:therapeutic use; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications; D006395:Hemarthrosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000382:microbiology; D011859:Radiography; D016059:Range of Motion, Articular; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; D003029:Coagulants