Pentraxin 3 increase is much less pronounced than C-reactive protein increase after surgical procedures.
Pentraxin 3 is an acute phase marker that belongs to the same protein family as C-reactive protein (CRP). The aim of this study was to compare the acute phase reactions of pentraxin 3 and CRP in humans. High sensitivity CRP and pentraxin 3 were analyzed in blood samples from orthopedic surgery (n = 29) and coronary bypass patients (n = 21). The samples were collected prior to surgery and 4 and 30 days after surgery, respectively. Both CRP and pentraxin 3 were significantly increased at day 4. Median pentraxin 3 values increased from 4,021 to 7,459 pg/mL in the orthopedic group and from 4,637 pg/mL to 10,419 pg/mL in the coronary bypass group while CRP increased from 6.3 mg/L to 151.6 mg/L and from 5.7 mg/L to 176.3 mg/L in the same groups. Pentraxin 3 shows a much smaller increment in humans in comparison with CRP.
Åkerfeldt
Torbjörn
T
Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85, Uppsala, Sweden.
Larsson
Anders
A
D000210:Acute-Phase Reaction / Q000097:blood* / Q000276:immunology; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000009:adverse effects; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects; D011184:Postoperative Period; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D000099153:Pentraxins
D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins