title: Intraretinal segmentation on fourier domain optical coherence tomography.
abstract: BACKGROUND
  We studied the automated intraretinal segmentation on Fourier domain optical coherence tomography (OCT).
  
  
  METHODS
  Thirty eyes from 30 normal subjects were studied using the RTVue-100. Both radial and raster scan protocol were performed 3 times on each subject. The OCT software performs automated intraretinal segmentation and provides macular thickness measurements.
  
  
  RESULTS
  Both scanning protocols provide reproducible inner, outer and full retinal thickness measurements. The inner, outer and full retinal thicknesses at the foveal central subfield were 67.31 +/- 12.27 microm, 151.67 +/- 12.96 microm, 219.33 +/- 23.19 microm, respectively by the raster scan, and 63.27 +/- 10.37 microm, 147.07 +/- 14.54 microm, 209.89 +/- 21.80 microm, respectively by the radial scan. Macular regional variations were consistently observed. The raster scan protocol gives greater retinal thickness measurements than the radial scan protocol (P <0.05), but the latter yields slightly more reproducible results.
  
  
  CONCLUSIONS
  Fourier domain OCT equipped with the ability to perform automatic intraretinal segmentation is a convenient tool in studying diseases that may differentially affect various parts of the retina. However, the establishment of normative values can be complicated by different scanning protocols, devices used, methods of data presentation and definition of intraretinal boundaries.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Wu
authors.forename: Dan
authors.initials: D
authors.lastname: Cao
authors.forename: Srinivas
authors.initials: S
authors.lastname: Sadda
mesh_terms: D000328:Adult; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008266:Macula Lutea / Q000033:anatomy & histology*; D008875:Middle Aged; D012016:Reference Values; D012164:Retinal Diseases / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*; D055815:Young Adult