title: Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder.
abstract: BACKGROUND
  To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD).
  
  
  METHODS
  We recruited 117 MDD patients who were randomized to fluoxetine or venlafaxine treatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates.
  
  
  RESULTS
  The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes.
  
  
  CONCLUSIONS
  Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently.
authors.affiliation: Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Mei Hung
authors.initials: MH
authors.lastname: Chi
authors.forename: Hui Hua
authors.initials: HH
authors.lastname: Chang
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Lee
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Po Wu
authors.initials: PW
authors.lastname: Gean
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000483:Alleles; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003511:Cyclohexanols / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D005473:Fluoxetine; D000069470:Venlafaxine Hydrochloride