title: [Treatment of painful neuromas via end-to-side neurorraphy].
abstract: BACKGROUND
  Management of the painful neuroma has been subject to controversy since the earliest descriptions of this disabling problem. Today, treatment is limited to resection of the neuroma and implantation of the nerve in a muscle at a location where it is safe from irritation and trauma. This however is not attainable in many cases and it is our clinical experience, that nerves without a target remain a source of constant discomfort and pain. Recently we reported of the feasibility of neuroma prevention through end-to-side neurorraphy into adjacent sensory and/or motor nerves to provide a target for axons deprived of their endorgan. Here we report of our first clinical experience with this method in sixteen patients with longstanding upper and lower extremity neuromas.
  
  
  METHODS
  16 patients were included in this study. All had neuromas of different sensory nerves of both the upper and lower extremity. 11 were of iatrogenic origin, 5 were caused by different traumas. 8 had previous attempts to surgically treat the neuroma. Finally, all were treated by end-to-side neurorraphy into adjacent nerves. Postoperatively quantitative sensorymotor testing was performed to evaluate possible changes of nerve function of the recipient nerves. Pain was evaluated by visual analogue score and changes in pain medication.
  
  
  RESULTS
  In no patient a sensory or motor deficit or painful sensations were induced in the target area of the recipient nerve. Some had dysaesthesias for about 6 months, which finally subsided. All but 1 patient improved in their symptoms at a follow-up of more than 2 years.
  
  
  CONCLUSIONS
  Previous experimental work and present clinical results suggest that axons of a severed peripheral nerve that are provided with a pathway and target through an end-to-side coaptation will either be pruned or establish some type of end-organ contact so that a neuroma can be prevented without inducing sensory or motor dysfunctions in the recipient nerve.
authors.affiliation: Abteilung für Plastische und Wiederherstellende und Asthetische Chirurgie, Universitätsklinik für Chirurgie der Medizinischen Universität Wien, Osterreich. oskar.aszmann@meduniwien.ac.at
authors.forename: O C
authors.initials: OC
authors.lastname: Aszmann
authors.forename: V
authors.initials: V
authors.lastname: Moser
authors.forename: M
authors.initials: M
authors.lastname: Frey
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical / Q000379:methods*; D001132:Arm / Q000294:innervation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007049:Iatrogenic Disease; D007866:Leg / Q000294:innervation*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D009416:Nerve Regeneration / Q000502:physiology; D009437:Neuralgia / Q000601:surgery*; D009463:Neuroma / Q000209:etiology / Q000601:surgery*; D010525:Peripheral Nerves / Q000601:surgery*; D010524:Peripheral Nervous System Neoplasms / Q000209:etiology / Q000601:surgery*