title: The cost-effectiveness of rotavirus vaccination in Malawi.
abstract: BACKGROUND
  Rotarix (GlaxoSmithKline), a newly licensed rotavirus vaccine requiring 2 doses, may have the potential to save hundreds of thousands of lives in Africa. Nations such as Malawi, where Rotarix is currently under phase III investigation, may nevertheless face difficult economic choices in considering vaccine adoption.
  
  
  METHODS
  The cost-effectiveness of implementing a Rotarix vaccine program in Malawi was estimated using published estimates of rotavirus burden, vaccine efficacy, and health care utilization and costs.
  
  
  RESULTS
  With 49.5% vaccine efficacy, a Rotarix program could avert 2582 deaths annually. With GAVI Alliance cofinancing, adoption of Rotarix would be associated with a cost of $5.07 per disability-adjusted life-year averted. With market pricing, Rotarix would be associated with a base case cost of $74.73 per disability-adjusted life-year averted. Key variables influencing results were vaccine efficacy, under-2 rotavirus mortality, and program cost of administering each dose.
  
  
  CONCLUSIONS
  Adopting Rotarix would likely be highly cost-effective for Malawi, particularly with GAVI support. This finding holds true across uncertainty ranges for key variables, including efficacy, for which data are becoming available.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. sberry8@jhmi.edu
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Berry
authors.forename: Benjamin
authors.initials: B
authors.lastname: Johns
authors.forename: Chuck
authors.initials: C
authors.lastname: Shih
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Berry
authors.forename: Damian G
authors.initials: DG
authors.lastname: Walker
mesh_terms: D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D008295:Malawi / Q000453:epidemiology; D012400:Rotavirus Infections / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000191:economics* / Q000276:immunology*
chemical_list: D022243:Rotavirus Vaccines