Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.
Studies using targeted gene deletion in mice have revealed distinct roles for individual isozymes of the protein kinase C (PKC) family of enzymes in regulating sensitivity to various drugs of abuse. These changes in drug sensitivity are associated with altered patterns of drug self-administration. The purpose of this review is to summarize behavioral studies conducted on mice carrying targeted deletions of genes encoding specific PKC isozymes (namely the beta, gamma, delta, and epsilon isozymes), and to critically evaluate the possibility of using pharmacological inhibitors of specific PKC isozymes as modulators of the sensitivity to various drugs of abuse, as well as potential aids in the treatment of substance use disorders.
Olive
Michael Foster
MF
Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA. olive@musc.edu
Newton
Philip M
PM
D000818:Animals; D016739:Behavior, Addictive / Q000201:enzymology / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D017353:Gene Deletion; D006801:Humans; D007527:Isoenzymes; D051379:Mice; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D012646:Self Administration; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics
D004791:Enzyme Inhibitors; D007527:Isoenzymes; D011493:Protein Kinase C