title: Innate immunity and remodelling.
abstract: A wide variety of cardiac disease states can induce remodelling and lead to the functional consequence of heart failure. These complex disease states involve a plethora of parallel signal transduction events, which may be associated with tissue injury or tissue repair. Innate immunity is activated in hearts injured in different ways, evident as cytokine release from the heart, activation of toll-like receptors involved in recognizing danger, and activation of the transcription factor nuclear factor kappa B. Nuclear factor kappa B regulates gene programmes involved in inflammation as well as the resolution of inflammation. The impact of this is an enigma; while cytokines, toll-like receptors, and nuclear factor kappa B appear to elicit myocardial protection in studies of preconditioning, the literature strongly indicates a detrimental role for activation of innate immunity in studies of acute ischaemia-reperfusion injury. The impact of activation of cardiac innate immunity on the long-term outcome in in vivo models of hypertrophy and remodelling is less clear, with conflicting results as to whether it is beneficial or detrimental. More research using genetically engineered mice as tools, different models of evoking remodelling, and long-term follow-up is required for us to conclude whether activation of the innate immune system is good, bad, or unimportant in chronic injury models.
authors.affiliation: Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Postbox 1103 Blindern, 0317, Oslo, Norway. guro.valen@medisin.uio.no
authors.forename: Guro
authors.initials: G
authors.lastname: Valen
mesh_terms: D016207:Cytokines / Q000378:metabolism; D006333:Heart Failure / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D009206:Myocardium / Q000276:immunology* / Q000473:pathology; D016328:NF-kappa B / Q000276:immunology; D051193:Toll-Like Receptors / Q000378:metabolism; D020257:Ventricular Remodeling
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D051193:Toll-Like Receptors