Efficacy of lanolin and bovine type I collagen in the treatment of childhood anal fissures: a prospective, randomized, controlled clinical trial.
OBJECTIVE
We designed an open-labeled, prospective, randomized, controlled clinical trial to test the efficacy of topical lanolin ointment (PureLan) and bovine type I collagen spray (Gelfix) in the treatment of childhood anal fissures.


METHODS
Seventy-one children with acute anal fissure were divided randomly into three groups: group I (control; n = 25), group II (PureLan; n = 28), and group III (Gelfix; n = 18). All children were assigned to have warm sitz baths, topical analgesic creams, and stool softeners. Patients in groups II and III were also treated with topical lanolin ointment and bovine type I collagen, respectively. All children were re-examined 4 weeks later.


RESULTS
Complete healing of the anal fissure was observed in 68% of the group I patients, but in 92.9% and 100% of the group II and III patients, respectively. The difference among groups was significant in terms of complete fissure healing (P = 0.003), but the efficacy of topical lanolin ointment and bovine type I collagen spray did not differ significantly (P = 0.078).


CONCLUSIONS
Our data suggest that topical lanolin ointment and bovine type I collagen spray are effective in the treatment of acute anal fissure in children.
Büyükyavuz
Behçet Ilker
BI
Department of Pediatric Surgery, Süleyman Demirel University Medical School, 32260, Isparta, Turkey.
Savaş
Cagri
C
Duman
Levent
L
D000293:Adolescent; D000367:Age Factors; D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D024042:Collagen Type I / Q000627:therapeutic use*; D003358:Cosmetics / Q000627:therapeutic use*; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007809:Lanolin / Q000627:therapeutic use*; D008297:Male; D011347:Procollagen / Q000627:therapeutic use*
D024042:Collagen Type I; D003358:Cosmetics; D011347:Procollagen; D007809:Lanolin