Influence of glutathione-S-transferase theta (GSTT1) and micro (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan.
OBJECTIVE
Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and micro (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese.


METHODS
Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls.


RESULTS
Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age <56 years old with GSTT1 present genotype have a risk of 2.77-fold (95% CI: 1.09-7.09) for HCC compared to that with null variant, after adjustment for other confounders.


CONCLUSIONS
GSTT1 and GSTM1 null genotypes do not associate with increased risk of HCC.
Kao
Chia-Chun
CC
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chen
Mu-Kuan
MK
Kuo
Wu-Hsien
WH
Chen
Tzy-Yen
TY
Su
Shih-Chi
SC
Hsieh
Yi-Hsien
YH
Liu
Chuen-Lan
CL
Chou
Ming-Chih
MC
Tsai
Hsiu-Ting
HT
Yang
Shun-Fa
SF
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D013624:Taiwan
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1