title: Case of endophthalmitis following intravitreal injections of bevacizumab.
abstract: OBJECTIVE
  We report a case of infectious endophthalmitis that developed after the third intravitreal injection of bevacizumab. The endophthalmitis was caused by Staphylococcus epidermidis.
  
  
  METHODS
  Observational case series.
  
  
  RESULTS
  This was a case of a 77-year-old man who had received three intravitreal injections of bevacizumab and developed infectious endophthalmitis. Polymerase chain reaction of an aqueous humor sample showed that the endophthalmitis was caused by S. epidermidis. The patient received intravitreal ceftazidime and vancomycin, and subconjunctival injection of vancomycin. After the intravitreal injections he was treated with topical levofloxacin and cefmenoxime hydrochloride, and intravenous cefpirome. Subsequently, the ocular inflammation gradually decreased and his visual acuity remained at 30/200.
  
  
  CONCLUSIONS
  Our findings indicate that endophthalmitis can develop after intravitreal bevacizumab injections. Polymerase chain reaction is useful for differentiation from sterile endophthalmitis.
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu-shi, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Komori
authors.forename: Akira
authors.initials: A
authors.lastname: Sawada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oguni
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ohkusu