title: Urine albumin excretion, within normal range, reflects increasing prevalence of metabolic syndrome in patients with essential hypertension.
abstract: Microalbuminuria is a prognostic marker of cardiovascular disease and is related to metabolic syndrome (MetS). For this purpose, the authors examined the relationship of low grade albuminuria to MetS, using 4 current definitions and a MetS score. They studied 6650 consecutive, nondiabetic, hypertensive patients with normal microalbumin excretion. MetS was defined by Adult Treatment Panel III, American Heart Association, World Heart Organization, International Diabetes Federation criteria, and MetS Gruppo Italiano per lo Studio della Streptochinasi nell'Infarcto Miocardico (GISSI) score. Urine microalbumin concentration was measured after a 24-hour urine collection by immunonephelometry. By all definitions, hypertensive patients with MetS had higher microalbumin levels. Significantly higher microalbumin levels were observed as the number of metabolic components rose. After adjustment for systolic blood pressure, the strength of this association was reduced to a nonsignificant level. Microalbumin levels, within normal range, are increased in patients with MetS, irrespective of the definition criteria.
authors.affiliation: Hypertension Unit, 1st Cardiology Clinic, Athens University, Hippokration Hospital, V. Sofias 108 Avenue, Athens, Greece.
authors.forename: Gregory
authors.initials: G
authors.lastname: Vyssoulis
authors.forename: Eva
authors.initials: E
authors.lastname: Karpanou
authors.forename: Pangiotis
authors.initials: P
authors.lastname: Spanos
authors.forename: Stella-Maria
authors.initials: SM
authors.lastname: Kyvelou
authors.forename: Dionysios
authors.initials: D
authors.lastname: Adamopoulos
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis* / Q000652:urine*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000652:urine; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000652:urine; D008875:Middle Aged; D015995:Prevalence; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors