Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp.
Previous studies have shown that venoms of social wasps and bees exhibit strong anticoagulant activity. The present study describes the anticoagulant and fibrinogen-degrading pharmacological properties of the venom of Polybia occidentalis social wasp. The results demonstrated that this venom presented anticoagulant effect, inhibiting the coagulation at different steps of the clotting pathway (intrinsic, extrinsic and common pathway). The venom inhibited platelet aggregation and degraded plasma fibrinogen, possibly containing metal-dependent metalloproteases that specifically cleave the Bβ-chain of fibrinogen. In conclusion, fibrinogenolytic and anticoagulant properties of this wasp venom find a potential application in drug development for the treatment of thrombotic disorders. For that, further studies should be carried out in order to identify and isolate the active compounds responsible for these effects.
Czaikoski
Paula G
PG
Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto/USP, Ribeirão Preto, São Paulo, Brazil.
Menaldo
Danilo L
DL
Marcussi
Silvana
S
Baseggio
Anne L C
AL
Fuly
André L
AL
Paula
Rafael C
RC
Quadros
Andreza U
AU
Romão
Pedro R T
PR
Buschini
Maria L T
ML
Cunha
Fernando Q
FQ
Soares
Andreimar M
AM
Monteiro
Marta C
MC
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D045726:Metalloproteases / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D014862:Wasp Venoms / Q000494:pharmacology*; D014863:Wasps
D000925:Anticoagulants; D014862:Wasp Venoms; D005340:Fibrinogen; D045726:Metalloproteases