Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects.
OBJECTIVE
The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGFI concentrations in healthy subjects.


METHODS
Two hundred and forty-one consecutive healthy subjects were included in the present study.


METHODS
Serum IGF-I and 25-(OH) D3 concentrations.


RESULTS
As expected, serum IGF-I concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF-I levels. A positive relationship was identified between serum 25-(OH) D3 and IGF-I concentrations (r=0.33, p<0.0001); the 25-(OH) D3-dependent changes of serum IGF-I concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D3 deficiency (<20 ng/ml) had lower (185 ± 83 μg/l) IGF-I values than those with mild-to absent 25-(OH) D3 deficit (225 ± 83 μg/l, p=0.0004).


CONCLUSIONS
25-(OH) D3 status may contribute to determine serum IGF-I levels in healthy population.
Bogazzi
F
F
Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
Rossi
G
G
Lombardi
M
M
Tomisti
L
L
Sardella
C
C
Manetti
L
L
Curzio
O
O
Marcocci
C
C
Grasso
L
L
Gasperi
M
M
Martino
E
E
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood; D055815:Young Adult
D014807:Vitamin D; D007334:Insulin-Like Growth Factor I