title: Warfarin-induced skin necrosis mimicking calciphylaxis: a case report and review of the literature.
abstract: Warfarin-induced skin necrosis (WISN) and calciphylaxis share similar early clinical findings and can both lead to significant morbidity and mortality. The authors reviewed the literature on both conditions and describe a case of extensive skin necrosis in a patient with end-stage renal disease who was initially suspected to have calciphylaxis. Further investigation supported a diagnosis of WISN. The pathogenesis, clinical manifestations and treatment of WISN and calciphylaxis are discussed, with emphasis on a diagnostic approach for early recognition.
authors.affiliation: Division of Internal Medicine, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA. chacongina@yahoo.com
authors.forename: Gina
authors.initials: G
authors.lastname: Chacon
authors.forename: Timmy
authors.initials: T
authors.lastname: Nguyen
authors.forename: Akram
authors.initials: A
authors.lastname: Khan
authors.forename: Animesh
authors.initials: A
authors.lastname: Sinha
authors.forename: Supriya
authors.initials: S
authors.lastname: Maddirala
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D002114:Calcinosis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin