[Professional eosinophilic bronchitis: considerations and new diagnostic methods in a clinical case].
Nonasthmatic eosinophilic bronchitis (NAEB) is a condition characterized by corticosteroid-responsive chronic cough, sputum eosinophilia and absence of symptoms or objective evidence of variable airflow obstruction and airway hyper-responsiveness. Like asthma, NAEB can be associated with exposure to occupational sensitizers and can be considered as being a variant of occupational asthma when it develops as a consequence of work exposure. Few case reports of NAEB caused by workplace exposure have been reported. Bakers are at high risk of developing occupational respiratory disorders and three cases of occupational NAEB have been described. We describe the first case of occupational NAEB due to storage mites in a baker in which the offending agent was identified by means of the basophil activation test (BAT), a new tool which has never been proposed in diagnostic procedures of occupational respiratory allergy. BAT's results allowed the recognition of the offending agent, that is mandatory for diagnosis.
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Servizio Autonomo di Allergologia e Immunologia Clinica, Fondazione "Salvatore Maugeri", IRCCS, Istituto Scientifico di Pavia, Italia. giannipalass@libero.it
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D000730:Androstadienes / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D015549:Basophil Degranulation Test; D029481:Bronchitis, Chronic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003371:Cough / Q000276:immunology; D004802:Eosinophilia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D005433:Flour; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D009784:Occupational Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011237:Predictive Value of Tests; D012129:Respiratory Function Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D013183:Sputum / Q000166:cytology; D016896:Treatment Outcome; D017132:Workplace
D000730:Androstadienes; D001993:Bronchodilator Agents; D000068298:Fluticasone