Treatment of oral florid papillomatosis with systemic administration of photocarcinorin: an effective photodynamic therapy.
OBJECTIVE
To evaluate the safety and effect of systemic administration of photosensitizer Photocarcinorin (PsD-007) in the treatment of oral florid papillomatosis (OFP).


BACKGROUND
OFP is a rare and refractory disease characterized by multiple papillomatous lesions. The outcomes of many methods for OFP are not satisfactory.


METHODS
Photosensitizer Photocarcinorin (5 mg/kg) was intravenously injected into a 59-year-old woman with widespread OFP, and the lesions were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity and 106.2 J/cm(2) energy density. The therapy was performed once a month for 3 months in total.


RESULTS
After three courses, the small lesions disappeared, and the larger ones were reduced by ≥80%. The adverse effects were minimal.


CONCLUSIONS
Systemic PDT is an effective and successful treatment modality for OFP, especially in elderly patients.
Lu
Yuan-gang
YG
Department of Dermatology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. xll515@163.com
Wu
Jin-jin
JJ
Lei
Xia
X
Zhu
Tang-you
TY
He
Yang
Y
Chen
Ling
L
Cheng
Qiong-hui
QH
D005260:Female; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy*; D010212:Papilloma / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D006415:Hematoporphyrins; D017319:Photosensitizing Agents; C052552:photocarcinorin