Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles.
Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.
Thomas
Courtney R
CR
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA.
Ferris
Daniel P
DP
Lee
Jae-Hyun
JH
Choi
Eunjoo
E
Cho
Mi Hyeon
MH
Kim
Eun Sook
ES
Stoddart
J Fraser
JF
Shin
Jeon-Soo
JS
Cheon
Jinwoo
J
Zink
Jeffrey I
JI
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
D000970:Antineoplastic Agents; D012822:Silicon Dioxide; D004317:Doxorubicin