False-positive rate of a "fourth-generation" HIV antigen/antibody combination assay in an area of low HIV prevalence.
We retrospectively analyzed the performance of the Architect HIV antigen/antibody (Ag/Ab) combination assay in a tertiary health care center with a situation of low HIV prevalence. The specificity and positive predictive value (PPV) were 99.78% and 31.21%, respectively. However, the specificity and PPV could increase to 99.99% and 89.70% using an arbitrary cutoff value.
Kim
Sinyoung
S
Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul, South Korea.
Lee
Jong-Han
JH
Choi
Jun Yong
JY
Kim
June Myung
JM
Kim
Hyon-Suk
HS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005189:False Positive Reactions; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014773:Virology / Q000379:methods*; D055815:Young Adult
D000956:Antigens, Viral; D015483:HIV Antibodies