Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors.
Previously, we reported new methods for ultrasound signal characterization using entropy, H(f); a generalized entropy, the Renyi entropy, I(f)(r); and a limiting form of Renyi entropy suitable for real-time calculation, I(f),(infinity). All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, I(f),(infinity), is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.
Marsh
Jon N
JN
Wallace
Kirk D
KD
McCarthy
John E
JE
Wickerhauser
Mladen V
MV
Maurizi
Brian N
BN
Lanza
Gregory M
GM
Wickline
Samuel A
SA
Hughes
Michael S
MS
D000465:Algorithms; D000818:Animals; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D003287:Contrast Media; D019277:Entropy; D005260:Female; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D014183:Transplantation, Heterologous; D014463:Ultrasonography / Q000379:methods*
D003287:Contrast Media