title: Early hematopoietic effects of chronic radiation exposure in humans.
abstract: The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. The study is based on about 3,200 hemograms taken for inhabitants of the Techa riverside villages over the years 1951-1956, i.e., the period characterized by a gradual decrease in dose rates. The mean cumulative red bone marrow dose was 333.6 + or - 4.6 mGy. The approach to statistical analyses involved both empirical methods and modeling (generalized linear models and logistic regressions). The results of the analyses highlighted a gradual increase in the frequency of cytopenias with dose rate. The impact of exposure on hematopoiesis reduction patterns was found to be more substantial than that of age and health status. Dose rates resulting in a two-fold increase in the frequency of cytopenias have been estimated.
authors.affiliation: Urals Research Center for Radiation Medicine (URCRM), 68-a Vorovsky Street, 454076, Chelyabinsk, Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Akleyev
authors.forename: Igor V
authors.initials: IV
authors.lastname: Akushevich
authors.forename: Georgy P
authors.initials: GP
authors.lastname: Dimov
authors.forename: Galina A
authors.initials: GA
authors.lastname: Veremeyeva
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Varfolomeyeva
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Ukraintseva
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Yashin
mesh_terms: D000367:Age Factors; D001772:Blood Cell Count; D001773:Blood Cells / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D001853:Bone Marrow / Q000528:radiation effects; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D006410:Hematopoiesis / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D018499:Linear Energy Transfer; D016015:Logistic Models; D008875:Middle Aged; D011005:Plutonium / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism; D012189:Retrospective Studies; D045483:Rivers; D012426:Russia / Q000453:epidemiology; D013997:Time Factors
chemical_list: D011005:Plutonium