title: Design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]choline and [(11)C]methionine with radiopharmaceutical quality.
abstract: We herein describe the design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]methionine and [(11)C]choline for human use. Kits were designed for maximal simplicity and ease of using modules from Eckert & Ziegler Modular Lab System. The use of all-disposable sterile medical-grade material, helps ensure safety and cGMP compliance. The quick set-up and removal ("plug & play") also reduces radiation burden to operator.
authors.affiliation: Radiopharmacy Unit, Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av. Pío XII 36, 31008 Pamplona, Spain. gquinfer@unav.es
authors.forename: Gemma
authors.initials: G
authors.lastname: Quincoces
authors.forename: Luisa
authors.initials: L
authors.lastname: López-Sánchez
authors.forename: María
authors.initials: M
authors.lastname: Sánchez-Martínez
authors.forename: Macarena
authors.initials: M
authors.lastname: Rodríguez-Fraile
authors.forename: Iván
authors.initials: I
authors.lastname: Peñuelas
mesh_terms: D001331:Automation; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000138:chemical synthesis*; D008715:Methionine / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline