Axonal transport: CDKs as traffic signals for motor-ists along the axon?
A screen for axonal cargo mislocalization in Caenorhabditis elegans neurons implicates the cyclin-dependent kinases CDK-5 and PCT-1 and the cyclin CCY-1 in the regulation of the microtubule motor cytoplasmic dynein.
Holzbaur
Erika
E
University of Pennsylvania, School of Medicine, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA.
D000818:Animals; D001369:Axons / Q000378:metabolism*; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism; D056445:Cytoplasmic Dyneins / Q000378:metabolism*; D017238:Genes, Helminth; D008870:Microtubules / Q000378:metabolism; D009046:Motor Neurons / Q000378:metabolism
D016213:Cyclins; D051360:Cyclin-Dependent Kinase 5; D056445:Cytoplasmic Dyneins