An association study of 21 potential Alzheimer's disease risk genes in a Finnish population.
Alzheimer's disease (AD) is a genetically complex disorder encompassing several individual susceptibility genes with low risk effects. To assess the risk gene effects in a cohort consisting of ∼ 1300 Finnish AD patients and controls, 21 candidate gene polymorphisms were selected for genotyping on the basis of the meta-analyses retrieved from the AlzGene database. A significant genotype and allele association with AD was observed with rs1800629 in the tumor necrosis factor α (TNF). Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD.
Sarajärvi
Timo
T
Institute of Clinical Medicine-Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Helisalmi
Seppo
S
Antikainen
Leila
L
Mäkinen
Petra
P
Koivisto
Anne Maria
AM
Herukka
Sanna-Kaisa
SK
Haapasalo
Annakaisa
A
Soininen
Hilkka
H
Hiltunen
Mikko
M
D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016208:Databases, Factual; D005387:Finland; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
D014409:Tumor Necrosis Factor-alpha