Effect on renal function of an iso-osmolar contrast agent in patients with monoclonal gammopathies.
OBJECTIVE
To assess the safety of the non-ionic iso-osmolar contrast agent iodixanol on renal function in patients with monoclonal gammopathies undergoing CT.


METHODS
We explored the effect of iodixanol on renal function in 30 patients with monoclonal gammopathies and 20 oncological patients with a normal electrophoretic profile (control group). The parameters used to estimate renal function were: serum creatinine, eGFR (determined 24 h before and 48 h after the administration of iodixanol), and urinary excretion of Neutrophil Gelatinase-Associated Lipocalin (NGAL) determined 2 h and 24 h after. Serum creatinine was also determined 1 month after the administration of iodixanol.


RESULTS
No significant increase in serum creatinine values were observed in the monoclonal gammopathies group and in 19/20 patients in the control group. Only 1 patient in the control group developed a transient contrast agent-induced nephropathy. We found no statistically significant difference between the two groups regarding the percentage variation from baseline values of serum creatinine, creatinine clearance, NGAL 2 h after, and eGFR. Whereas NGAL at 24 h showed a statistically significant increase in patients with Monoclonal gammopathies.


CONCLUSIONS
The use of iodixanol appears to be safe in patients with monoclonal gammopathies and an eGFR≥ 60 ml/min/1.73 mq.
Preda
Lorenzo
L
Division of Radiology, European Institute of Oncology IRCCS, Milan, Italy. lorenzo.preda@ieo.it
Agazzi
Alberto
A
Raimondi
Sara
S
Lanfranchi
Carla Federica
CF
Passerini
Rita
R
Calvetta
Albania
A
Martinelli
Giovanni
G
Bellomi
Massimo
M
D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000175:diagnosis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000494:pharmacology*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol