Conformational dynamics of actin: effectors and implications for biological function.
Actin is a protein abundant in many cell types. Decades of investigations have provided evidence that it has many functions in living cells. The diverse morphology and dynamics of actin structures adapted to versatile cellular functions is established by a large repertoire of actin-binding proteins. The proper interactions with these proteins assume effective molecular adaptations from actin, in which its conformational transitions play essential role. This review attempts to summarise our current knowledge regarding the coupling between the conformational states of actin and its biological function.
Hild
Gábor
G
Department of Biophysics, University of Pécs, Faculty of Medicine, Pécs, Szigeti str. 12, H-7624, Hungary.
Bugyi
Beáta
B
Nyitrai
Miklós
M
D000199:Actins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D003599:Cytoskeleton / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D000199:Actins; D008840:Microfilament Proteins