title: Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia.
abstract: OBJECTIVE
  Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE).
  
  
  METHODS
  After institutional review board approval, we enrolled subjects with EOSPE (<34 weeks' gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression.
  
  
  RESULTS
  Subjects with EOSPE (n = 50) were noted to have decreased total 25-OH-D levels relative to healthy control subjects (n = 100; P < .001). This difference in total 25-OH-D remained significant after control for potential confounders.
  
  
  CONCLUSIONS
  Total 25-OH-D is decreased at diagnosis of EOSPE. Further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Robinson
authors.forename: Mark C
authors.initials: MC
authors.lastname: Alanis
authors.forename: Carol L
authors.initials: CL
authors.lastname: Wagner
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Hollis
authors.forename: Donna D
authors.initials: DD
authors.lastname: Johnson
mesh_terms: D000328:Adult; D044383:Black People; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011863:Radioimmunoassay; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis; D044465:White People
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D