title: Renal dysfunction, metabolic syndrome and cardiovascular disease mortality.
abstract: Background. Renal disease is commonly described as a complication of metabolic syndrome (MetS) but some recent studies suggest that Chronic Kidney disease (CKD) may actually antecede MetS. Few studies have explored the predictive utility of co-clustering CKD with MetS for cardiovascular disease (CVD) mortality. Methods. Data from a nationally representative sample of United States adults (NHANES) was utilized. A sample of 13115 non-pregnant individuals aged >/=35 years, with available follow-up mortality assessment was selected. Multivariable Cox Proportional hazard regression analysis techniques explored the relationship between co-clustered CKD, MetS and CVD mortality. Bayesian analysis techniques tested the predictive accuracy for CVD Mortality of two models using co-clustered MetS and CKD and MetS alone. Results. Co-clustering early and late CKD respectively resulted in statistically significant higher hazard for CVD mortality (HR = 1.80, CI = 1.45-2.23, and HR = 3.23, CI = 2.56-3.70) when compared with individuals with no MetS and no CKD. A model with early CKD and MetS has a higher predictive accuracy (72.0% versus 67.6%), area under the ROC (0.74 versus 0.66), and Cohen's kappa (0.38 versus 0.21) than that with MetS alone. Conclusion. The study findings suggest that the co-clustering of early CKD with MetS increases the accuracy of risk prediction for CVD mortality.
authors.affiliation: Department of Medicine, Charles Drew University of Medicine and Science, 1731 E 20th Street, Los Angeles, CA 90059, USA.
authors.forename: David
authors.initials: D
authors.lastname: Martins
authors.forename: Chizobam
authors.initials: C
authors.lastname: Ani
authors.forename: Deyu
authors.initials: D
authors.lastname: Pan
authors.forename: Omolola
authors.initials: O
authors.lastname: Ogunyemi
authors.forename: Keith
authors.initials: K
authors.lastname: Norris