Bisphenol-A: a new diabetogenic factor?
The aim of this review was to analyze the potential effects of environmental chemicals on homeostatic control related to glycemia and energy balance. Many of the environmental chemicals can mimic or interfere with the action of hormones and are generally referred to as "endocrine disruptors". Among these compounds, polychlorinated biphenyls, dioxins, phthalates and bisphenol-A have been correlated with alterations in blood glucose homeostasis in humans. In rodents it has been demonstrated that small doses of bisphenol-A have profound effects on glucose metabolism. Therefore, this altered blood glucose homeostasis may enhance the development of type 2 diabetes.
Alonso-Magdalena
Paloma
P
CIBER of Diabetes and Associated Metabolic Diseases, CIBERDEM, lnstitute of Bioengineering, University Miguel Hernandez of Elche, Elche, Spain. palonso@umh.es
Ropero
Ana Belin
AB
Soriano
Sergi
S
Quesada
Ivan
I
Nadal
Angel
A
D000818:Animals; D001559:Benzhydryl Compounds; D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000139:chemically induced*; D052244:Endocrine Disruptors / Q000009:adverse effects*; D004734:Energy Metabolism / Q000187:drug effects; D004785:Environmental Pollutants / Q000009:adverse effects*; D004958:Estradiol / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D006706:Homeostasis; D006801:Humans; D010636:Phenols / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D001786:Blood Glucose; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D004958:Estradiol; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds