title: Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks.
abstract: Conventional microfluidic devices typically require highly precise pumps or pneumatic control systems, which add considerable cost and the requirement for power. These restrictions have limited the adoption of microfluidic technologies for point-of-care applications. Paper networks provide an extremely low-cost and pumpless alternative to conventional microfluidic devices by generating fluid transport through capillarity. We revisit well-known microfluidic devices for hydrodynamic focusing, sized-based extraction of molecules from complex mixtures, micromixing, and dilution, and demonstrate that paper-based devices can replace their expensive conventional microfluidic counterparts.
authors.affiliation: Department of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA. jlaj@u.washington.edu
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Osborn
authors.forename: Barry
authors.initials: B
authors.lastname: Lutz
authors.forename: Elain
authors.initials: E
authors.lastname: Fu
authors.forename: Peter
authors.initials: P
authors.lastname: Kauffman
authors.forename: Dean Y
authors.initials: DY
authors.lastname: Stevens
authors.forename: Paul
authors.initials: P
authors.lastname: Yager
mesh_terms: D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010209:Paper; D014159:Transducers