Myeloid-derived suppressor cells in human cancer.
Myeloid-derived suppressor cells are one of the major factors responsible for immune suppression in cancer. They also contribute to limited efficacy of current vaccination strategies. Here, we give an overview of the myeloid-derived suppressor cells field focusing primarily on the studies in cancer patients and current and future therapeutic options targeting these cells.
Nagaraj
Srinivas
S
Division of Translational Medicine, Department of Internal Medicine, University of South Florida, Tampa, FL, USA.
Gabrilovich
Dmitry I
DI
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D051379:Mice; D022423:Myeloid Cells / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology