A new rodent behavioral paradigm for studying forelimb movement.
The center-out task is a standard paradigm often used to study the neural control of reaching movements in human and non-human primates. However, there are several disadvantages to the use of monkeys, notably costs, infrastructural requirements, and ethical considerations. Here we describe a similar task designed to examine forelimb movements in rats. Rats were trained to grasp a joystick with their forepaw and use it to control the movements of a sipper tube in two dimensions. The rats learned to move the joystick in four directions with at least 70% accuracy after about 45 days of training. In addition, rats were able to learn a reversed mapping between joystick and sipper tube movement. This is a more complicated behavior than has been previously demonstrated for rats, and it could allow more motor behavior studies to be conducted in rodents instead of monkeys. We currently are using this behavior to decode the rats' forelimb movements from their brain signals.
Slutzky
Marc W
MW
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States. mslutzky@md.northwestern.edu
Jordan
Luke R
LR
Bauman
Matthew J
MJ
Miller
Lee E
LE
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004576:Electromyography; D005552:Forelimb / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D017207:Rats, Sprague-Dawley; D012815:Signal Processing, Computer-Assisted