Keeping the epidermal stem cell niche in shape.
Recently in Nature Cell Biology,Connelly et al. (2010) identified biomechanical sensing mechanisms that link the physical shape of the stem cell microenvironment to epithelial stem cell fate decisions. Ultimately, the integration of extrinsic and intrinsic signals controls stem cell self-renewal or differentiation.
Iglesias-Bartolome
Ramiro
R
Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
Gutkind
J Silvio
JS