title: Sensitization to contact allergens and bronchial hyper-responsiveness.
abstract: BACKGROUND
  Exposure to contact allergens and specific allergic sensitization to them are common, but possible related health effects have been rarely studied.
  
  
  OBJECTIVE
  We aimed to analyse possible associations between contact sensitization to nickel sulfate and fragrance mix I and lung function parameters or bronchial hyper-responsiveness.
  
  
  METHODS
  Within a population-based study in Augsburg, 1052 adults performed lung function tests, including forced expiratory volume in 1 second (FEV(1)), forced vital capacity (FVC) and bronchial hyper-responsiveness (BHR). Patch tests were performed, and information was assessed by medical examinations and interviews. Logistic regression models were applied to study associations between contact allergies and lung function parameters.
  
  
  RESULTS
  Women were sensitized significantly more often than men to nickel [odds ratio (OR) 3.97, 95% confidence interval (CI) 2.50-6.29] and fragrance mix I (OR 2.28, 95% CI 1.50-3.46). Patch test results for nickel and fragrance mix I did not influence mean FEV(1) and FVC % predicted values. However, in women, a higher rate of BHR was associated with positive patch test reactions to fragrance mix I (OR 2.24, 95% CI 1.11-4.52).
  
  
  CONCLUSIONS
  Contact sensitization to fragrance mix I is associated with a higher rate of BHR in women. Thus, in women with contact allergy to fragrances, airway obstruction should be considered as a possible co-morbidity.
authors.affiliation: Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany. Schnabel@helmholtz-muenchen.de
authors.forename: Eva
authors.initials: E
authors.lastname: Schnabel
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Schoefer
authors.forename: Chih-Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: Torsten
authors.initials: T
authors.lastname: Schäfer
authors.forename: Heidrun
authors.initials: H
authors.lastname: Behrendt
authors.forename: Johannes
authors.initials: J
authors.lastname: Ring
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000633:toxicity*; D010328:Patch Tests; D010476:Perfume / Q000633:toxicity*; D012129:Respiratory Function Tests; D012737:Sex Factors
chemical_list: D000485:Allergens; D010476:Perfume; C029938:nickel sulfate; D009532:Nickel