title: Interrelationships between 3-T-MRI-derived cortical and trabecular bone structure parameters and quantitative-computed-tomography-derivedbone mineral density.
abstract: Recently, 3-T magnetic resonance imaging (MRI) has been introduced for bone imaging. Through higher signal-to-noise ratios, as compared to 1.5-T MRI, it promises to be a more powerful tool for the assessment of cortical and trabecular bone measures. The goal of our study was to compare MRI-derived cortical and trabecular bone measures to quantitative computed tomography (QCT)-derived bone mineral density (BMD). Using 3-T MRI in 51 postmenopausal women, apparent (app.) measures of bone volume/total volume, trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation were derived at the distal radius, distal tibia and calcaneus. Cortical thickness (Ct.Th) was calculated at the distal radius and distal tibia. These measures were compared to QCT-derived BMD of the spine, hip and radius. Significant correlations ((*)P<.05; (**)P<.001; (***)P<.0001) were found between spine BMD- and MRI-derived Ct.Th (r(radius)=.55, (*)P<.05; r(tibia)=.67, (***)P<.0001) and app. Tb.N (r(radius)=.33, (*)P<.05; r(tibia)=.35, (*)P<.05) at the radius and tibia. Furthermore, within the first 10 mm at the radius, an inverse correlation for Ct.Th and app. BV/TV (r(6mm)=-.56, P<.001; r(10mm)=-.36, P<.05) and app. Tb.Th (r(6mm)=-.54, P<.001; r(10mm)=-.41, P<.05) was found.
authors.affiliation: Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, China Basin, San Francisco, CA 94107, USA. ahi-sema.issever@charite.de
authors.forename: Ahi Sema
authors.initials: AS
authors.lastname: Issever
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Link
authors.forename: David
authors.initials: D
authors.lastname: Newitt
authors.forename: Thelma
authors.initials: T
authors.lastname: Munoz
authors.forename: Sharmila
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010024:Osteoporosis / Q000473:pathology; D017698:Postmenopause; D014057:Tomography, X-Ray Computed / Q000379:methods*