title: Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor.
abstract: Ten vitamin K(3) derivatives were synthesized and screened for anti-angiogenic activity. Results indicated that amine derivatives (1a-d) exerted a stronger inhibition effect on angiogenesis compared to alkyl derivatives (2a-d). In addition to being the most potent inhibitor, 1b also suppressed human umbilical vein endothelial cell tube formation and proliferation. These results suggest that vitamin K(3) amine derivatives with shorter alkyl chains, such as 1b, could be useful for developing anti-angiogenic agents.
authors.affiliation: Department of Human Life Science Education, Graduate School of Education, Hiroshima University, 1-1-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8524, Japan. tkaya@shujitsu.ac.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kayashima
authors.forename: Masaharu
authors.initials: M
authors.lastname: Mori
authors.forename: Ryo
authors.initials: R
authors.lastname: Mizutani
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nishio
authors.forename: Kouji
authors.initials: K
authors.lastname: Kuramochi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tsubaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mizushina
authors.forename: Kiminori
authors.initials: K
authors.lastname: Matsubara
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D024483:Vitamin K 3 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D024483:Vitamin K 3