title: Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction.
abstract: T1ρ relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there were low frequency relaxation mechanisms that suppress endogenous contrast at low spin-lock amplitudes and in T2-weighted images. A moderate amplitude spin-locking pulse could overcome these relaxation mechanisms. Relaxation dispersion data were measured over a range of RF field amplitudes, and a model was formulated to include dipole-dipole relaxation modulated by molecular rotation and an apparent exchange mechanism. These techniques may find some use in the clinic for the observation of chronic, left ventricular cardiac remodeling.
authors.affiliation: Department of Radiology, Medical Physics, University Hospital Freiburg, Freiburg im Breisgau, Germany. walter.witschey@uniklinik-freiburg.de
authors.forename: Walter R T
authors.initials: WR
authors.lastname: Witschey
authors.forename: James J
authors.initials: JJ
authors.lastname: Pilla
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ferrari
authors.forename: Kevin
authors.initials: K
authors.lastname: Koomalsingh
authors.forename: Mohammed
authors.initials: M
authors.lastname: Haris
authors.forename: Robin
authors.initials: R
authors.lastname: Hinmon
authors.forename: Gerald
authors.initials: G
authors.lastname: Zsido
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Gorman
authors.forename: Robert C
authors.initials: RC
authors.lastname: Gorman
authors.forename: Ravinder
authors.initials: R
authors.lastname: Reddy
mesh_terms: D000465:Algorithms; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis*; D015203:Reproducibility of Results; D012399:Rotation; D012680:Sensitivity and Specificity; D013113:Spin Labels; D013552:Swine; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D013113:Spin Labels