title: The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains.
abstract: The SCHIC domain of the B12-binding domain family present in the Rhodobacter sphaeroides AppA protein binds heme and senses oxygen. Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA.
authors.affiliation: Department of Molecular Biology, University of Wyoming, Dept. 3944, 1000 E. University Ave., Laramie, WY 82071, USA.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Moskvin
authors.forename: Marie-Alda
authors.initials: MA
authors.lastname: Gilles-Gonzalez
authors.forename: Mark
authors.initials: M
authors.lastname: Gomelsky
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006418:Heme / Q000378:metabolism*; D008969:Molecular Sequence Data; D010788:Photosynthesis / Q000235:genetics / Q000502:physiology*; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D012242:Rhodobacter sphaeroides / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins; D006418:Heme