title: Domino approach for the synthesis of pyrrolo[1,2-alpha]pyrazine from vinyl azides.
abstract: A domino synthesis of pyrrolo[1,2-alpha]pyrazine from 1H-2-pyrrolecarbaldehyde and readily synthesized vinyl azides was developed. This reaction proceeded under relatively mild conditions in the presence of base. Additionally, a possible mechanism for the entire sequence is proposed.
authors.affiliation: Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
authors.forename: Wenteng
authors.initials: W
authors.lastname: Chen
authors.forename: Miao
authors.initials: M
authors.lastname: Hu
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zou
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001386:Azides; D011719:Pyrazines; D011758:Pyrroles; D014753:Vinyl Compounds