Structures of new Erythrinan alkaloids and nitric oxide production inhibitors from Erythrina crista-galli.
Two new Erythrinan alkaloids, cristanines A and B (1, 2), were isolated from the bark of Erythrina crista-galli L. together with nine known Erythrinan alkaloids (3-5, 7-12) and an indole alkaloid (13). The structures of the compounds, cristanines A (1) and B (2), were elucidated by spectroscopic methods. Three of the twelve compounds isolated showed significant inhibitory activity on lipopolysaccharide induced nitric oxide (NO) production.
Ozawa
Masaaki
M
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyodaku, Japan.
Kawamata
Shunsuke
S
Etoh
Tadahiro
T
Hayashi
Masahiko
M
Komiyama
Kanki
K
Kishida
Akio
A
Kuroda
Chiaki
C
Ohsaki
Ayumi
A
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004895:Erythrina / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D013237:Stereoisomerism
D000470:Alkaloids; D010936:Plant Extracts; C554032:cristanine A; C554033:cristanine B; D009569:Nitric Oxide