title: Synthesis and Biological Evaluation of New CRH Analogues.
abstract: A series of 7 new human/rat Corticotropin Releasing Hormone (h/r-CRH) analogues were synthesized. The induced alterations include substitution of Phe at position 12 with D-Phe, Leu at positions 14 and 15 with Aib and Met at positions 21 and 38 with Cys(Et) and Cys(Pr). The analogues were tested regarding their binding affinity to the CRH-1 receptor and their activity which is represented by means of percentage of maximum response in comparison to the native molecule. The results indicated that the introduction of Aib, or Cys derivatives although altering the secondary structure of the molecule, did not hinder receptor recognition and binding.
authors.affiliation: Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26500 Patras, Greece.
authors.forename: Spyridon
authors.initials: S
authors.lastname: Papazacharias
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Magafa
authors.forename: Nicole
authors.initials: N
authors.lastname: Bernad
authors.forename: George
authors.initials: G
authors.lastname: Pairas
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Spyroulias
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Paul
authors.initials: P
authors.lastname: Cordopatis