Mucosa-associated lymphoma tissue of the dura presenting as meningioma.
Mucosa-associated lymphoma tissue (MALT) of the dura is extremely rare, with only a few reported cases worldwide. We present a unique case of a 61-year-old female who presented with neurologic symptoms of unsteady gait, dizziness, and sharp pain on her scalp for 3 weeks. A subsequent magnetic resonance imaging (MRI) of the brain demonstrated a dural-based mass radiographically consistent with meningioma. However, biopsy revealed the cells to be immunopositive for CD20 and CD79a, and immunonegative for CD5, CD10, CD43, and CD23. The neoplastic small lymphoid B cells were MUM1 positive and showed kappa light chain restriction, consistent with MALT of the dura. No evidence of systemic disease was found. The patient underwent radiation, which resulted in a complete response. MALT lymphoma, while rare, must be considered in the differential diagnosis in patients presenting radiographically with meningioma.
Shaia
John
J
Division of Hematology and Oncology, George Washington University Medical Center, Washington, DC, USA.
Kerr
P Benjamin
PB
Saini
Ashima
A
Roberti
Fabio
F
Kapil
Jyoti
J
Jones
Robert
R
Aragon-Ching
Jeanny B
JB
D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D004244:Dizziness / Q000209:etiology; D004388:Dura Mater / Q000473:pathology*; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D010146:Pain / Q000209:etiology; D014839:Vomiting / Q000209:etiology