Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction.
T1ρ relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there were low frequency relaxation mechanisms that suppress endogenous contrast at low spin-lock amplitudes and in T2-weighted images. A moderate amplitude spin-locking pulse could overcome these relaxation mechanisms. Relaxation dispersion data were measured over a range of RF field amplitudes, and a model was formulated to include dipole-dipole relaxation modulated by molecular rotation and an apparent exchange mechanism. These techniques may find some use in the clinic for the observation of chronic, left ventricular cardiac remodeling.
Witschey
Walter R T
WR
Department of Radiology, Medical Physics, University Hospital Freiburg, Freiburg im Breisgau, Germany. walter.witschey@uniklinik-freiburg.de
Pilla
James J
JJ
Ferrari
Giovanni
G
Koomalsingh
Kevin
K
Haris
Mohammed
M
Hinmon
Robin
R
Zsido
Gerald
G
Gorman
Joseph H
JH
Gorman
Robert C
RC
Reddy
Ravinder
R
D000465:Algorithms; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis*; D015203:Reproducibility of Results; D012399:Rotation; D012680:Sensitivity and Specificity; D013113:Spin Labels; D013552:Swine; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology*
D013113:Spin Labels