Comment on recent modeling studies of astrocyte-neuron metabolic interactions.
Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.
Jolivet
Renaud
R
Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland. renaud.jolivet@a3.epfl.ch
Allaman
Igor
I
Pellerin
Luc
L
Magistretti
Pierre J
PJ
Weber
Bruno
B
D001253:Astrocytes / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism*
D001786:Blood Glucose; D006003:Glycogen