title: Adverse neurologic reactions after both doses of pandemic H1N1 influenza vaccine with optic neuritis and demyelination.
abstract: When a neurologic condition develops after vaccination of a patient, the causal relationship is difficult to determine. We report an unusual case in which neurologic signs occurred in a previously healthy child after both doses of H1N1 2009 influenza vaccine, culminating in bilateral optic neuritis and disseminated encephalomyelitis. A causal association is more likely with repeated injury following influenza vaccination.
authors.affiliation: Vaccine Evaluation Center, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. klapphra@cfri.ca
authors.forename: Keswadee
authors.initials: K
authors.lastname: Lapphra
authors.forename: Linda
authors.initials: L
authors.lastname: Huh
authors.forename: David W
authors.initials: DW
authors.lastname: Scheifele
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002675:Child, Preschool; D004673:Encephalomyelitis, Acute Disseminated / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009902:Optic Neuritis / Q000175:diagnosis / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D007252:Influenza Vaccines; D008775:Methylprednisolone