[Primary neurolymphomatosis of the cervical nerve root].
A 74-year-old woman was admitted with muscle weakness and sharp pain in her upper limbs. On (18)FDG-PET, abnormal accumulation was noted on both sides of the brachial plexus at the cervical spinal cord. A diagnosis of primary peripheral nerve neurolymphomatosis was made based on biopsy of the third cervical nerve. Following R-CHOP therapy, the abnormal accumulation of (18)FDG-PET scan disappeared. However, disturbance of consciousness occurred 6 months later and recurrence as multiple brain tumors was detected. Although salvage chemotherapy was performed, the patient died of overwhelming sepsis. Primary peripheral nerve neurolymphomatosis is extremely rare. Early distinct diagnosis using (18)FDG-PET and combination chemotherapy of rituximab and high dose methotrexate may improve the outcome for such patients.
Miki
Miyuki
M
Department of Hematology and Immunology, Kanazawa Medical University.
Masaki
Yasufumi
Y
Nakamura
Takuji
T
Iwao
Haruka
H
Nakajima
Akio
A
Sakai
Tomoyuki
T
Sawaki
Toshioki
T
Kawanami
Takafumi
T
Kaito
Muichi
M
Kurose
Nozomu
N
Fujita
Yoshimasa
Y
Tanaka
Masao
M
Fukushima
Toshihiro
T
Hirose
Yuko
Y
Umehara
Hisanori
H
D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002574:Cervical Vertebrae; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000628:therapy*; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000008:administration & dosage; D000069283:Rituximab; D013126:Spinal Nerve Roots; D014750:Vincristine / Q000008:administration & dosage
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D008727:Methotrexate