title: 3DSDSCAR--a three dimensional structural database for sialic acid-containing carbohydrates through molecular dynamics simulation.
abstract: The inherent flexibility and lack of strong intramolecular interactions of oligosaccharides demand the use of theoretical methods for their structural elucidation. In spite of the developments of theoretical methods, not much research on glycoinformatics is done so far when compared to bioinformatics research on proteins and nucleic acids. We have developed three dimensional structural database for a sialic acid-containing carbohydrates (3DSDSCAR). This is an open-access database that provides 3D structural models of a given sialic acid-containing carbohydrate. At present, 3DSDSCAR contains 60 conformational models, belonging to 14 different sialic acid-containing carbohydrates, deduced through 10 ns molecular dynamics (MD) simulations. The database is available at the URL: http://www.3dsdscar.org.
authors.affiliation: Department of Physics, Manonmaniam Sundaranar University, Tirunelveli 627 012, Tamilnadu, India. kvraja@sancharnet.in
authors.forename: Kasinadar
authors.initials: K
authors.lastname: Veluraja
authors.forename: Jeyasigamani F A
authors.initials: JF
authors.lastname: Selvin
authors.forename: Selvakumar
authors.initials: S
authors.lastname: Venkateshwari
authors.forename: Thanu R K
authors.initials: TR
authors.lastname: Priyadarzini
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D019295:Computational Biology; D016208:Databases, Factual; D056004:Molecular Dynamics Simulation; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D019158:N-Acetylneuraminic Acid