[One year observation of natural course of aortic valve stenosis in patients with normal and abnormal lipoprotein (a) plasma level].
OBJECTIVE
The observation of natural course of aortic valvae stenosis (AVS) in patients with high lipoprotein (a) [Lp(a)].


METHODS
60 AVS patients who did not agree for operational treatment were divided into group A (n = 19) with high serum Lp(a) level and into group B (n = 41) with normal plasma Lp(a) level.


METHODS
Plasma Lp(a), total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha) as well as titers of immunoglobulin (Ig) class G, A, M against chlamydia pneumoniae were measured every 12 months. Echocardiographic evaluation of aortic valve was also done every 12 months.


RESULTS
Means serum CRP at 12 month was higher in group A. Mean serum TNF-alpha level was also higher at visit I and at 12 month (visit II) in group A. Mean serum IL-6 level did not differ between groups. IgG titer was higher in group A at visit I and visit II. At 12 month of observation HDL-cholesterol plasma level was lower in group A. HDL/total cholesterol ratio as well as HDL/LDL-cholesterol ratio was laso lower in group A at 12 month of observation. No statistically significant differences in echocardiographic parameters were founf between groups.


CONCLUSIONS
The results may suggest risk factors similarity of AVS and atherosclerosis.
Swierszcz
Jolanta
J
II Klinika Kardiologii Collegium Medicum, Uniwersytetu Jagiellońskiego. grasshoppers@interia.eu
Dubiel
Jacek S
JS
Milewicz
Tomasz
T
Sztefko
Krystyna
K
Galicka-Latała
Danuta
D
Pfitzner
Roman
R
Wodniecki
Jan
J
Krzysiek
Józef
J
D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D008076:Cholesterol, HDL; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015850:Interleukin-6; D017270:Lipoprotein(a); D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D002784:Cholesterol