title: Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma.
abstract: Melanoma is the most lethal form of skin malignancy because of its aggressive behaviour. In advanced disease, interferon alfa can be used as adjuvant therapy. However, this therapy is not free of side effects. We present a case of severe Raynaud syndrome and digital necrosis induced by interferon alfa in a patient with melanoma. Pathogenic mechanisms are discussed.
authors.affiliation: Department of Dermatology, San Cecilio University Hospital, Granada, Spain. huseinelahmed@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Husein-Elahmed
authors.forename: J L
authors.initials: JL
authors.lastname: Callejas-Rubio
authors.forename: R
authors.initials: R
authors.lastname: Ortega Del Olmo
authors.forename: R
authors.initials: R
authors.lastname: Ríos-Fernandez
authors.forename: N
authors.initials: N
authors.lastname: Ortego-Centeno