Toxicity of airborne particulate matter to rat alveolar macrophages: A comparative study of five extracts collected indoors and outdoors.
The toxicity of indoor and outdoor air samples to rat alveolar macrophages was determined by studying the phagocytic activity of these cells in vitro. Clean air samples did not affect phagocytosis at concentrations up to 60 m(3)/plate, but polluted outdoor samples caused a dose-dependent inhibition of the phagocytosis at concentrations varying from 6 m(3) to 60 m(3)/plate. Indoor air samples, especially when polluted with wood smoke, affected phagocytosis at concentrations below 2 m(3)/plate.
van Houdt
J J
JJ
Department of Toxicology, Agricultural University, De Dreijen 12, 6703 BC Wageningen, The Netherlands; Department of Air Pollution, Agricultural University, De Dreijen 12, 6703 BC Wageningen, The Netherlands.
Rietjens
I M
IM