title: Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances.
abstract: Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody-antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.
authors.forename: K V
authors.initials: KV
authors.lastname: Purtov
authors.forename: A I
authors.initials: AI
authors.lastname: Petunin
authors.forename: A E
authors.initials: AE
authors.lastname: Burov
authors.forename: A P
authors.initials: AP
authors.lastname: Puzyr
authors.forename: V S
authors.initials: VS
authors.lastname: Bondar