title: Skin wounds associated with calciphylaxis in end-stage renal disease patients on dialysis.
abstract: Calciphylaxis is a rare complication of chronic renal failure mostly with poor prognosis. Painful lesions on various skin surface areas are the most prominent feature of this serious disease. Subsequent infection of necrotic skin tissue is associated with the risk of sepsis. Pathophysiology is unclear, but several risk factors are known. The most important risk factor is impaired calcium-phosphate metabolism. Our paper describes two cases of different forms of calciphylaxis in patients with chronic renal failure. In the first case, pamidronate and cinacalcet were used for treatment. In the second described case, calciphylaxis was associated with secondary hyperparathyroidism and immediate subtotal parathyroidectomy was performed. Both patients were successfully treated, using systemic approach as well as dedicated local care for healing of skin wounds.
authors.affiliation: Division of Nephrology, Department of Gerontology and Metabolism, Medical Faculty of Charles University and Faculty Hospital, Hradec Králové, Czech Republic.
authors.forename: Sylvie Dusilová
authors.initials: SD
authors.lastname: Sulková
authors.forename: Martin
authors.initials: M
authors.lastname: Válek
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002115:Calciphylaxis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000069449:Cinacalcet; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use; D000077268:Pamidronate; D016105:Parathyroidectomy; D006435:Renal Dialysis / Q000009:adverse effects*; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D009281:Naphthalenes; D000077268:Pamidronate; D000069449:Cinacalcet