title: Controlled evaluation of the effects of hyperbaric oxygen therapy on the behavior of 16 children with autism spectrum disorders.
abstract: Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors.
authors.affiliation: Thoughtful House Center for Children, Austin, TX, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Jepson
authors.forename: Doreen
authors.initials: D
authors.lastname: Granpeesheh
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tarbox
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Olive
authors.forename: Carol
authors.initials: C
authors.lastname: Stott
authors.forename: Scott
authors.initials: S
authors.lastname: Braud
authors.forename: J Helen
authors.initials: JH
authors.lastname: Yoo
authors.forename: Andrew
authors.initials: A
authors.lastname: Wakefield
authors.forename: Michael S
authors.initials: MS
authors.lastname: Allen
mesh_terms: D002648:Child; D002652:Child Behavior; D002659:Child Development Disorders, Pervasive / Q000628:therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D018579:Patient Selection; D016896:Treatment Outcome