title: Skin autofluorescence as marker of tissue advanced glycation end-products accumulation in formerly preeclamptic women.
abstract: CONCLUSIONS
  In women with a history of preeclampsia skin autofluorescence as marker of tissue AGEs accumulation is increased, supporting a common causal metabolic or vascular link between preeclampsia and cardiovascular diseases.
  
  
  OBJECTIVE
  To investigate whether skin autofluorescence (AF), as marker of tissue accumulation of advanced glycation end-products (AGEs), is elevated in women with a 4-year history of severe preeclampsia.
  
  
  METHODS
  About 17 formerly preeclamptic women and 16 controls were included. Skin AF and several traditional cardiovascular risk factors were recorded.
  
  
  RESULTS
  In comparison to controls, formerly preeclamptic women had higher skin AF of the legs, body mass index (BMI), blood pressure, and high-sensitivity C-reactive protein (hsCRP), HbA1C, and triglycerides in serum.
  
  
  CONCLUSIONS
  Skin AF as well as cardiovascular risk factors is elevated in formerly preeclamptic women. These results suggest a common causal vascular link between preeclampsia and cardiovascular diseases.
authors.affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands. s.m.coffeng@student.rug.nl
authors.forename: Sophie M
authors.initials: SM
authors.lastname: Coffeng
authors.forename: Judith
authors.initials: J
authors.lastname: Blaauw
authors.forename: Esteban T D
authors.initials: ET
authors.lastname: Souwer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rakhorst
authors.forename: Andries J
authors.initials: AJ
authors.lastname: Smit
authors.forename: Reindert
authors.initials: R
authors.lastname: Graaff
authors.forename: Jasper J
authors.initials: JJ
authors.lastname: van Doormaal
authors.forename: Jan G
authors.initials: JG
authors.lastname: Aarnoudse
authors.forename: Marijke M
authors.initials: MM
authors.lastname: Faas
authors.forename: Maria G
authors.initials: MG
authors.lastname: van Pampus
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism; D005260:Female; D005453:Fluorescence; D005500:Follow-Up Studies; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D011225:Pre-Eclampsia / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012307:Risk Factors; D012867:Skin / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced