title: Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release.
abstract: Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release are fabricated by the combination of template synthesis and ATRP grafting. The release of R-propranolol from the imprinted nanotubes in rats is restricted while the release of pharmacologically active S-enantiomer is greatly promoted.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. jfyin@rcees.ac.cn
authors.forename: Junfa
authors.initials: J
authors.lastname: Yin
authors.forename: Yue
authors.initials: Y
authors.lastname: Cui
authors.forename: Gengliang
authors.initials: G
authors.lastname: Yang
authors.forename: Hailin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D054802:Molecular Imprinting / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity; D011433:Propranolol / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011433:Propranolol