title: A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer.
abstract: Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) -2.408 (PR) -1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R² of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.
authors.affiliation: Department of Pathology, University of Rochester of Rochester Medical Center, New York, USA. ping_tang@urmc.rochester.edu
authors.forename: Ping
authors.initials: P
authors.lastname: Tang
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.forename: David G
authors.initials: DG
authors.lastname: Hicks
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Linda
authors.initials: L
authors.lastname: Schiffhauer
authors.forename: Loralee
authors.initials: L
authors.lastname: McMahon
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.forename: Michelle
authors.initials: M
authors.lastname: Shayne
authors.forename: Alissa
authors.initials: A
authors.lastname: Huston
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Skinner
authors.forename: Jennifer
authors.initials: J
authors.lastname: Griggs
authors.forename: Gary
authors.initials: G
authors.lastname: Lyman
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone