title: Acute arboviral infections in Guinea, West Africa, 2006.
abstract: Acute febrile illnesses comprise the majority of the human disease burden in sub-Saharan Africa. We hypothesized that arboviruses comprised a considerable proportion of undiagnosed febrile illnesses in Guinea and sought to determine the frequency of arboviral disease in two hospitals there. Using a standard case definition, 47 suspected cases were detected in approximately 4 months. Immunoglobulin M antibody capture enzyme-linked immunosorbent assays and plaque-reduction neutralization assays revealed that 63% (30/47) of patients were infected with arboviruses, including 11 West Nile, 2 yellow fever, 1 dengue, 8 chikungunya, and 5 Tahyna infections. Except for yellow fever, these are the first reported cases of human disease from these viruses in Guinea and the first reported cases of symptomatic Tahyna infection in Africa. These results strongly suggest that arboviruses circulate and are common causes of disease in Guinea. Improving surveillance and laboratory capacity for arbovirus diagnoses will be integral to understanding the burden posed by these agents in the region.
authors.affiliation: Department of Tropical Medicine, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA. ejentes@cdc.gov
authors.forename: Emily S
authors.initials: ES
authors.lastname: Jentes
authors.forename: Jaimie
authors.initials: J
authors.lastname: Robinson
authors.forename: Barbara W
authors.initials: BW
authors.lastname: Johnson
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Conde
authors.forename: Yosse
authors.initials: Y
authors.lastname: Sakouvougui
authors.forename: Jennifer
authors.initials: J
authors.lastname: Iverson
authors.forename: Shanna
authors.initials: S
authors.lastname: Beecher
authors.forename: M Alpha
authors.initials: MA
authors.lastname: Bah
authors.forename: Fousseny
authors.initials: F
authors.lastname: Diakite
authors.forename: Mamadi
authors.initials: M
authors.lastname: Coulibaly
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Bausch
authors.forename: Juliet
authors.initials: J
authors.lastname: Bryan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001102:Arbovirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D001103:Arboviruses / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016701:Guinea / Q000453:epidemiology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M