[Effects of deer tendons collagen on osteoporosis rats induced by retinoic acid].
OBJECTIVE
To study the effects of deer tendons collagen on osteoporosis rats induced by retinoic acid.


METHODS
Male Wistar rats were randomly divided into normal control group, model control group, deer tendons collagen high, medium and low-dose groups, osteoporosis rats of retinoic acid-induced were set up. Changes of body weight, bone weight, bone mineral density, bone histomorphometry, plasma phosphorus, calcium, alkaline phosphatase (ALP), bone mechanics were measured before and after treatment of deer tendons collagen.


RESULTS
Compared with model control group,after treated by deer tendons collagen, body weight, bone mineral density, bone weight was increased in varying degrees, bone histomorphometry parameters were significantly different, the ALP in plasma was significantly reduced, contents of Ca, P were increased, all indicators of bone mechanics were significantly higher.


CONCLUSIONS
Deer tendons collagen can prevent and treat retinoic acid-induced osteoporosis of rats.
Zhang
He
H
Changchun University of Traditional Chinese Medicine, Changchun 130117, China.
Zhao
Yu
Y
Li
Yin-Qing
YQ
Sun
Xiao-Di
XD
Bai
Xue-Yuan
XY
Zhao
Da-Qing
DQ
D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D003094:Collagen / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003670:Deer; D004195:Disease Models, Animal; D005269:Femur / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use*; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013710:Tendons; D014212:Tretinoin
D008419:Materia Medica; D014212:Tretinoin; D003094:Collagen; D000469:Alkaline Phosphatase; D002118:Calcium