A comparison of the effects of three different luteal phase support protocols on in vitro fertilization outcomes: a randomized clinical trial.
OBJECTIVE
To evaluate the effects of three different luteal phase support protocols on pregnancy and implantation rates, as well as luteal phase hormone profile in intracytoplasmic sperm injection-ET cycles.


METHODS
A prospective, randomized study.


METHODS
A tertiary teaching and research hospital.


METHODS
Two hundred eighty-eight patients who were undergoing intracytoplasmic sperm injection with a long protocol of controlled ovarian hyperstimulation.


METHODS
Group 1 (E(2) + P) received daily P plus 4 mg of E(2), group 2 (hCG + P) received P plus 1,500 IU of hCG, and group 3 (P only) received daily vaginal P gel. Blood samples were drawn on the day of hCG administration, as well as 7 and 10 days after the hCG for the E(2) and P measurements.


METHODS
The clinical pregnancy rate.


RESULTS
No difference existed between the E(2) + P and hCG + P groups with respect to pregnancy rate, but it was significantly lower in the P-only group.The implantation rate was significantly lower in the P-only group than in the other groups.The highest miscarriage rate was in the P-only group (38%).


CONCLUSIONS
In assisted reproductive technology cycles including treatment with GnRH agonist, adding 4 mg of oral E(2) to P during the luteal phase significantly increased the pregnancy and implantation rates and decreased the miscarriage rate compared with the use of P only.
Var
Turgut
T
Zekai Tahir Burak Woman's Health Education and Research Hospital, Assisted Reproduction Unit, Ankara, Turkey.
Tonguc
Esra Ayşin
EA
Doğanay
Melike
M
Gulerman
Cavidan
C
Gungor
Tayfun
T
Mollamahmutoglu
Leyla
L
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000008:administration & dosage; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol