title: The role of nuclear factor-kappaB in inflammatory lung disease.
abstract: Nuclear factor-kappaB (NF-kappaB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-kappaB in inflammatory lung disease, the strategies which block the activation of NF-kappaB, and the therapeutic approaches to treating inflammatory lung disease.
authors.affiliation: Research Center of Molecular Biology, Baqiyatallah Medical Sciences University, Tehran, Iran.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Imanifooladi
authors.forename: Samaneh
authors.initials: S
authors.lastname: Yazdani
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Nourani
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008171:Lung Diseases / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B