title: Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
abstract: Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at 550 nm. Beer's law was obeyed in the range of 5-45 mug mL(-1) for guaifenesin and 10-80 mug mL(-1) for dropropizine. Both drugs were also successfully determined in their dosage forms.
authors.affiliation: Faculty of Pharmacy, October University for Modern Sciences and Arts, El Wahat Road, 6th October City, Egypt.
authors.forename: Ola M
authors.initials: OM
authors.lastname: Abdallah