Acquired platelet dysfunction in 109 patients from a tertiary care referral hospital.
BACKGROUND
Acquired platelet function defects (PFDs) remain poorly characterized, underrecognized, and therefore understudied.


METHODS
Clinical and laboratory records of 109 patients with acquired PFDs diagnosed over 5 years were analyzed. Screening studies (platelet count, prothrombin time, activated partial thromboplastin time, and thrombin time), template bleeding time, platelet factor 3 (PF-3) availability test, light-transmission aggregometry, and further testing as indicated were performed.


RESULTS
64 patients had mild and 26 had major bleeding. In all, 15 were referred for preoperative testing, whereas 4 had thrombotic events. Causes and associations of PFDs were drug-induced (34), idiopathic (34), hematopoietic neoplasms (15; myeloma 4, Waldenstrom macroglobulinemia 2, chronic myeloid leukemia 4, essential thrombocythaemia 3, and primary myelofibrosis and chronic lymphocytic leukemia 1 each), chronic liver disease (4), postcardiac surgery (2), uremia (2), and thalassemia major (7). Miscellaneous disorders comprised the rest.


CONCLUSIONS
Acquired PFDs span a wide range of disease settings. Systematic, sequential laboratory testing identifies patterns of dysfunction, excludes inherited disorders, and streamlines management.
Sharma
Prashant
P
Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Kar
Rakhee
R
Bhargava
Rahul
R
Ranjan
Ravi
R
Pravas Chandra Mishra
Saxena
Renu
R
D001791:Blood Platelet Disorders / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011517:Prothrombin Time; D012017:Referral and Consultation; D013918:Thrombin Time