title: [Sarcomatoid carcinoma of the thymus].
abstract: Sarcomatoid carcinomas are rare malignancies composed of epithelial (carcinomatous) and sarcomatous elements. High-grade carcinoma is difficult to diagnose by light optic and immunohistochemical studies. The authors give the data available in the literature on sarcomatoid carcinoma of the thymus and also describe their own observation. Its histological pattern is represented by a combination of carcinomatous and sarcomatous elements with extensive necrotic foci. Immunohistologically, the tumor cells expressed total cytokeratin (AE1/AE3), CD99, and focally epithelial membrane antigen. Some tumor cells were vimentin- and SMA-positive. Markers, such as chromogranin A, bcl-2, bcl-6, S-100 protein and myogenin, were negative.
authors.forename: D V
authors.initials: DV
authors.lastname: Rogozhin
authors.forename: D M
authors.initials: DM
authors.lastname: Konovalov
authors.forename: M A
authors.initials: MA
authors.lastname: Andreeva
authors.forename: D A
authors.initials: DA
authors.lastname: Samoĭlov
authors.forename: A G
authors.initials: AG
authors.lastname: Kunitsin
authors.forename: R F
authors.initials: RF
authors.lastname: Savkova
authors.forename: M M
authors.initials: MM
authors.lastname: Konstantinova
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007120:Immunochemistry; D009336:Necrosis; D009363:Neoplasm Proteins / Q000378:metabolism*; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology; D013953:Thymus Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins