Prospects of molecular photoacoustic imaging at 1064 nm wavelength.
An analysis of the photoacoustic (PA) signal from murine tissue in vivo revealed several benefits of contrast-enhanced PA imaging at a wavelength of 1064nm. Of all the wavelengths tested in a range from 710 to 1064nm, the background PA signal from tissue in vivo was lowest and more homogeneous at 1064nm. For blood-laden tissue, the background PA signal was up to 70% less at 1064nm. Furthermore, when plasmonic nanoparticles, such as silver nanoplates, were introduced in vivo as contrast agents, the contrast in PA images at 1064nm increased 38% compared to 750nm. Therefore, contrast-enhanced PA imaging at 1064nm is advantageous because of the low and homogeneous signal from native tissue, enabling high contrast in PA imaging when exogenous, molecularly targeted agents are employed.
Homan
Kimberly
K
Biomedical Engineering Department, The University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Kim
Seungsoo
S
Chen
Yun-Sheng
YS
Wang
Bo
B
Mallidi
Srivalleesha
S
Emelianov
Stanislav
S
D000162:Acoustics; D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007834:Lasers; D008027:Light; D051379:Mice; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D009368:Neoplasm Transplantation; D055095:Optics and Photonics; D012834:Silver / Q000737:chemistry
D003287:Contrast Media; D012834:Silver