title: A dynamic microarray device for paired bead-based analysis.
abstract: In this study, we have developed a meander-shaped dynamic microfluidic technology that allows us to pair two different types of microbeads in a trapping site. The dynamic microfluidic technology comprises implemented modifications of a conventional dynamic microarray design such as: (i) the combination of a meander-shaped by-pass channel and a trapping channel with a hydrodynamic trapping site and (ii) line-symmetrical formation of the by-pass and trapping channels. Using these modifications, we have successfully trapped different types of sample in one trapping site, and constructed an array of paired beads of different type such as polystyrene beads or hydrogel beads made of agarose, collagen or alginate. We found that this meander-shaped dynamic microfluidic technology is applicable for the observation of interactions between the paired beads such as molecular diffusion.
authors.affiliation: Institute of Industrial Science, The University of Tokyo, Meguro-ku, Japan.
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Teshima
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ishihara
authors.forename: Kosuke
authors.initials: K
authors.lastname: Iwai
authors.forename: Aki
authors.initials: A
authors.lastname: Adachi
authors.forename: Shoji
authors.initials: S
authors.lastname: Takeuchi
mesh_terms: D004058:Diffusion; D020100:Hydrogels / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D008863:Microspheres; D011137:Polystyrenes / Q000737:chemistry
chemical_list: D020100:Hydrogels; D011137:Polystyrenes