title: A history of prior bare metal stent restenosis is associated with major adverse cardiac events in subsequent bare metal stenting of de novo coronary lesions.
abstract: OBJECTIVE
  To investigate the risk of major adverse cardiac events (MACE) in patients with a history of bare metal stent (BMS) restenosis who undergo subsequent bare metal stenting of a geographically distinct, de novo coronary lesion.
  
  
  METHODS
  We conducted a retrospective review of 72 BMS procedures performed in geographically distinct, de novo coronary lesions in patients with a history of previous BMS placement at least 3 months prior to the second, index stent procedure. Patients with a history of in-stent restenosis (ISR) were compared with those who had no ISR in their initial stent.
  
  
  RESULTS
  Restenosis in the initial BMS was associated with a significant increase in MACE after placement of the index BMS (OR 20.0, 95% CI 3.86-103.58, p < 0.0001). This association was independent of traditional clinical and angiographic risk factors for restenosis.
  
  
  CONCLUSIONS
  Restenosis of a previously placed BMS is strongly associated with MACE after placement of a subsequent BMS in a de novo coronary lesion.
authors.affiliation: Department of Cardiology, National Naval Medical Center8901 Wisconsin AvenueBethesda, MD 20889, USA. drmfergus@yahoo.com
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ferguson
authors.forename: Matthew
authors.initials: M
authors.lastname: Needleman
authors.forename: Eric S
authors.initials: ES
authors.lastname: Mitchell
authors.forename: Luther I
authors.initials: LI
authors.lastname: Carter
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Bustamante
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Love
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Curran
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications / Q000628:therapy; D003324:Coronary Artery Disease / Q000209:etiology*; D023903:Coronary Restenosis / Q000150:complications* / Q000628:therapy; D003430:Cross-Sectional Studies; D005260:Female; D006772:Hospitals, Military; D006801:Humans; D016015:Logistic Models; D008297:Male; D008670:Metals; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D014481:United States
chemical_list: D008670:Metals