[Autoimmune thyroiditis (Hashimoto's thyroiditis): current diagnostics and therapy].
Hashimoto's thyroiditis is a common autoimmune thyroid disease with preference of female gender. The chronic thyroiditis is characterized by autoantibodies against thyroid peroxidase and thyroglobulin. With manifestation, there is often a subclinical hypothyroidism that finally progresses to a persistent hypothyroidism with typical clinical symptoms and the need of hormonal substitution in succession of the lymphocytic infiltration of the thyroid. The ultrasound of the thyroid shows a hypoechogenic and inhomogeneous parenchyma. Autoimmune thyroiditis is frequently associated with autoimmune disease of other organs, such as vitiligo, Addison's disease, diabetes mellitus type 1, often in the sense of polyglandular syndrome 2.
Fink
Heike
H
Medizinische Klinik, Asklepios Klinik Bad Oldesloe, Bad Oldesloe, Germany. h.fink@asklepios.com
Hintze
Gerhard
G
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D007247:Infertility, Female / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D007328:Insulin / Q000627:therapeutic use; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use; D014463:Ultrasonography
D001323:Autoantibodies; D007328:Insulin; D013954:Thyroglobulin; D007453:Iodide Peroxidase; D013974:Thyroxine