title: Longitudinal studies of SRC family kinases in imatinib- and dasatinib-resistant chronic myelogenous leukemia patients.
abstract: This report aims to more accurately define the frequency of the involvement of SRC Family Kinases (SFKs) in imatinib- and dasatinib-resistant CML patients. Clinical samples were analysed during in vivo treatment. We confirmed the high frequency of SFKs involvement in Tyrosine kinase inhibitor-resistant CML (52% of the cases) and even further in progressive disease and blast crises (60% of the cases). The SFKs deregulation is also observed in patients harboring BCR-ABL mutations. In T315I and F317L mutated patients, CML-resistance appears to be promoted by SFKs kinase protein reactivation once the BCR-ABL mutated clone has decreased on Omacetaxine.
authors.affiliation: Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Laboratory for Molecular Biology and UMR5239 CNRS, Pierre-Bénite, France. sandrine.hayette@chu-lyon.fr
authors.forename: Sandrine
authors.initials: S
authors.lastname: Hayette
authors.forename: Kaddour
authors.initials: K
authors.lastname: Chabane
authors.forename: Mauricette
authors.initials: M
authors.lastname: Michallet
authors.forename: Estelle
authors.initials: E
authors.lastname: Michallat
authors.forename: Pascale
authors.initials: P
authors.lastname: Cony-Makhoul
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Salesse
authors.forename: Véronique
authors.initials: V
authors.lastname: Maguer-Satta
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Magaud
authors.forename: Franck E
authors.initials: FE
authors.lastname: Nicolini
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001483:Base Sequence; D001549:Benzamides; D045744:Cell Line, Tumor; D017931:DNA Primers; D000069439:Dasatinib; D019008:Drug Resistance, Neoplasm; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D008137:Longitudinal Studies; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*; D019061:src-Family Kinases / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D017931:DNA Primers; D010879:Piperazines; D011743:Pyrimidines; D013844:Thiazoles; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl; D019061:src-Family Kinases; D000069439:Dasatinib