title: Serum immunoglobulins in non-Hodgkin's lymphoma patients.
abstract: Serum proteins and immunoglobulin (Ig) findings in 119 non-Hodgkin's lymphoma (NHL) patients were analysed. Out of them 96 (81%) patients had B non-Hodgkin lymphoma (B-NHL), and 23 (19%) T-NHL. Indolent type of NHL was more frequent (77 patients, 65%), then aggressive type of NHL (42 patients, 35%). Most patients had normal serum protein concentration, the increased protein concentration was seen in 17% of patients while decreased concentration was noticed in 7% of patients. Hypoalbuminaemia was more frequent (43%) then hyperalbuminaemia (1%). In contrast to albumin, low levels of other protein fractions (alpha1-, alpha2-, and beta-globulin) were rather rare (0.6%, 4%, and 3% of patients, respectively) and high levels were frequent (23%, 37%, and 8%, respectively). Polyclonal hyperimmunoglobulinaemia was more frequent finding than hypoimmunoglobulinaemia. In 29% patients higher IgG level and in 25% patients higher IgA level were found. IgM hypoimmunoglobulinaemia (22%) was more frequent than IgG (11%) and IgA (8%) hypoimmunoglobulinaemia. M-spike in serum protein electrophoresis was found in 11 (7%) patients. The statistically significant association was not found between serum Ig concentration and lymphoma malignancy grade as well as between serum Ig concentration and immunologic origin of lymphoma. T-NHL patients have more often IgA concentration level above or under normal values than B-NHL patients (p < 0.05).
authors.affiliation: Department of Medicine, "Merkur" University Hospital, Zagreb, Croatia. ananas2907@hotmail.com
authors.forename: Ana
authors.initials: A
authors.lastname: Planinc-Peraica
authors.forename: Slobodanka Ostojić
authors.initials: SO
authors.lastname: Kolonić
authors.forename: Delfa
authors.initials: D
authors.lastname: Radić-Kristo
authors.forename: Mara
authors.initials: M
authors.lastname: Dominis
authors.forename: Branimir
authors.initials: B
authors.lastname: Jaksić
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000276:immunology* / Q000473:pathology; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D012709:Serum Albumin; D012712:Serum Globulins