title: Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
abstract: Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.
authors.affiliation: Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Takata
authors.forename: Shusuke
authors.initials: S
authors.lastname: Akamatsu
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Naoya
authors.initials: N
authors.lastname: Hosono
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Johji
authors.initials: J
authors.lastname: Inazawa
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujioka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hidewaki
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D044466:Asian People / Q000235:genetics*; D002277:Carcinoma / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002882:Chromosomes, Human, Pair 13; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*