title: The correlation coefficient of GC content of the genome-wide genes is positively correlated with animal evolutionary relationships.
abstract: In this study, we present a new method for evaluating animal evolutionary relationships. We used the GC% levels of genome-wide genes to determine the correlation between the GC% content and evolutionary relationship. The correlation coefficients of the GC% content of the orthologous genes of the paired animal species were calculated for a total of 21 species, and the evolutionary branching dates of these 21 species were derived from fossil records. The correlation coefficient of the GC% content of the orthologous genes of the species pair under study served as an indicator of their evolutionary relationship. Moreover, there was a decreasing linear relationship between the correlation coefficient and evolutionary branching date (R(2)=0.930).
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Du
authors.forename: Haofu
authors.initials: H
authors.lastname: Hu
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Meng
authors.forename: Weihao
authors.initials: W
authors.lastname: Zheng
authors.forename: Fei
authors.initials: F
authors.lastname: Ling
authors.forename: Jufang
authors.initials: J
authors.lastname: Wang
authors.forename: Xiquan
authors.initials: X
authors.lastname: Zhang
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Nie
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001482:Base Composition; D002415:Cats; D002417:Cattle; D017124:Conserved Sequence; D004285:Dogs; D019143:Evolution, Molecular; D016678:Genome; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats