title: Treatment of oral florid papillomatosis with systemic administration of photocarcinorin: an effective photodynamic therapy.
abstract: OBJECTIVE
  To evaluate the safety and effect of systemic administration of photosensitizer Photocarcinorin (PsD-007) in the treatment of oral florid papillomatosis (OFP).
  
  
  BACKGROUND
  OFP is a rare and refractory disease characterized by multiple papillomatous lesions. The outcomes of many methods for OFP are not satisfactory.
  
  
  METHODS
  Photosensitizer Photocarcinorin (5 mg/kg) was intravenously injected into a 59-year-old woman with widespread OFP, and the lesions were irradiated for 10 min by using a 635-nm laser beam of 177 mW/cm(2) intensity and 106.2 J/cm(2) energy density. The therapy was performed once a month for 3 months in total.
  
  
  RESULTS
  After three courses, the small lesions disappeared, and the larger ones were reduced by ≥80%. The adverse effects were minimal.
  
  
  CONCLUSIONS
  Systemic PDT is an effective and successful treatment modality for OFP, especially in elderly patients.
authors.affiliation: Department of Dermatology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. xll515@163.com
authors.forename: Yuan-gang
authors.initials: YG
authors.lastname: Lu
authors.forename: Jin-jin
authors.initials: JJ
authors.lastname: Wu
authors.forename: Xia
authors.initials: X
authors.lastname: Lei
authors.forename: Tang-you
authors.initials: TY
authors.lastname: Zhu
authors.forename: Yang
authors.initials: Y
authors.lastname: He
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Qiong-hui
authors.initials: QH
authors.lastname: Cheng
mesh_terms: D005260:Female; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy*; D010212:Papilloma / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D006415:Hematoporphyrins; D017319:Photosensitizing Agents; C052552:photocarcinorin