title: Papillary renal cell carcinoma with lipocyte-like cells: a rare morphological variant or an indication of aggressiveness?
abstract: Papillary renal cell carcinoma (PRCC) is the second most common carcinoma of the kidney, which is classified into two types. Type 1 displays single layer of cells with scanty pale cytoplasm and type 2 has pseudostratified high-grade nuclei with eosinophilic cytoplasm. Recently, apart from these two types, oncocytic PRCC and clear-cell PRCC have been described. To the best of our knowledge, lipocyte-like cells have not yet been reported to accompany any subtypes of renal cell carcinoma. Herein, we report a case of PRCC with lipocyte-like cells and sarcomatoid features. Lipocyte-like cells might represent a special type of PRCC or this feature may be an indication of poor prognosis regarding its association with sarcomatoid change.
authors.affiliation: Department of Pathology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Sari
authors.forename: Gozde
authors.initials: G
authors.lastname: Evcim
authors.forename: Murat
authors.initials: M
authors.lastname: Ermete
authors.forename: Kaan
authors.initials: K
authors.lastname: Bal
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bolukbasi
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008853:Microscopy; D019998:Racemases and Epimerases / Q000032:analysis
chemical_list: D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase