title: Signal transduction: RABGEF1 fingers RAS for ubiquitination.
abstract: RAS proteins conduct signaling from surface receptors to cytoplasmic effectors, and RAS gain-of-function mutations are pervasive in cancer. A new mechanism for RAS signal attenuation with implications for receptor trafficking has been uncovered.
authors.affiliation: Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. colicelli@mednet.ucla.edu
authors.forename: John
authors.initials: J
authors.lastname: Colicelli
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D054875:Ubiquitination; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D020662:Guanine Nucleotide Exchange Factors; C108382:RABGEF1 protein, human; D018631:ras Proteins