Comparison of the impaired fasting blood glucose in young healthy individuals with diabetic and non-diabetic first degree relatives.
OBJECTIVE
To compare the fasting blood glucose (FBG) level in the healthy young individuals with diabetic first degree relatives considered as high risk and non-diabetic first degree relative considered as low risk.


METHODS
Cross-sectional, comparative study.


METHODS
Department of Medicine, Liaquat University of Medical and Health Sciences Hospital, Hyderabad/Jamshoro, from January to November 2008.


METHODS
Individuals aged between 20-40 years were selected and divided into two groups. Group A was considered as high risk included non-diabetic young offspring's of type-2 diabetic parents. Group B was considered as low risk nondiabetic offsprings of non-diabetic family (control group), of same age and gender. Fasting blood glucose levels were measured in each individual. Exclusion criteria were known diabetes and pregnancy. Mean glucose levels were compared using t-test. Proportions of impaired glucose level versus positive family history were compared using chi-square test. Significance was considered at p<0.05.


RESULTS
There were a total of 500 subjects including 250 in each group with equal gender distribution in each group. The mean age was 27.46+/-5.71 years. Mean FBG was 87.4+/-13.82 mg/dl in group A and 77.7+/-15.18 mg/dl in group B (p=0.001). Twenty five (10%) in group A and five (2%) in group B individuals showed impaired fasting blood glucose (p=0.001).


CONCLUSIONS
Impairment of fasting blood glucose was with family history of type-2 Diabetes mellitus in comparison to those without type-2 Diabetes mellitus.
Shaikh
Mumtaz Ali
MA
Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro. ali_mumtazali@yahoo.com
Kumar
Raj
R
Ghori
Rafi Ahmed
RA
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D018570:Risk Assessment; D055815:Young Adult
D001786:Blood Glucose