title: Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD.
abstract: BACKGROUND
  Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD.
  
  
  METHODS
  A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL.
  
  
  RESULTS
  The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P < .0001). In addition, mortality was significantly increased in recurrent exacerbators with MBL-deficient genotypes compared with those with non-MBL-deficient genotypes (66.7% vs 31.0%, respectively; P = .0153).
  
  
  CONCLUSIONS
  MBL deficiency due to MBL2 polymorphisms increases the risk of recurrent infective exacerbation and worsens its outcome in patients with COPD.
authors.affiliation: Graduate Institute of Medical Sciences, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chii-Lan
authors.initials: CL
authors.lastname: Lin
authors.forename: Leung-Kei
authors.initials: LK
authors.lastname: Siu
authors.forename: Jung-Chung
authors.initials: JC
authors.lastname: Lin
authors.forename: Chien-Ying
authors.initials: CY
authors.lastname: Liu
authors.forename: Chih-Feng
authors.initials: CF
authors.lastname: Chian
authors.forename: Chun-Nin
authors.initials: CN
authors.lastname: Lee
authors.forename: Feng-Yee
authors.initials: FY
authors.lastname: Chang
mesh_terms: D000368:Aged; D004247:DNA / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000172:deficiency / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications / Q000235:genetics*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000097:blood / Q000150:complications* / Q000235:genetics
chemical_list: D037601:Mannose-Binding Lectin; D004247:DNA