title: Detrimental clinical interaction between ritonavir-boosted protease inhibitors and vinblastine in HIV-infected patients with Hodgkin's lymphoma.
abstract: In order to analyze the clinical relevance of the pharmacokinetic interactions between vinblastine and antiretrovirals described in literature, we evaluated all HIV-infected patients with Hodgkin's lymphoma treated with vinblastine-containing regimens and combination antiretroviral therapy, in a single clinical center. The use of protease inhibitors was independently associated with WHO grade III-IV neutropenia. Moreover, an inverse correlation between dosage of ritonavir and mean nadir neutrophil count was found. The concomitant administration of vinblastine-containing chemotherapy regimens with protease inhibitors can lead to higher levels of neutropenia than those of different classes of drugs such as nonnucleoside reverse transcriptase inhibitors or integrase inhibitors.
authors.affiliation: Institute of Infectious Diseases, Catholic University, Rome, Italy. a.cingolani@rm.unicatt.it
authors.forename: Antonella
authors.initials: A
authors.lastname: Cingolani
authors.forename: Lorenza
authors.initials: L
authors.lastname: Torti
authors.forename: Carmela
authors.initials: C
authors.lastname: Pinnetti
authors.forename: Katleen
authors.initials: K
authors.lastname: de Gaetano Donati
authors.forename: Rita
authors.initials: R
authors.lastname: Murri
authors.forename: Evelina
authors.initials: E
authors.lastname: Tacconelli
authors.forename: Luigi Maria
authors.initials: LM
authors.lastname: Larocca
authors.forename: Luciana
authors.initials: L
authors.lastname: Teofili
mesh_terms: D000328:Adult; D000368:Aged; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014747:Vinblastine / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D017320:HIV Protease Inhibitors; D014747:Vinblastine; D019438:Ritonavir