Synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines, and aldehydes catalyzed by magnetic Fe(3)O(4) nanoparticles in water.
A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride, amines, and aldehydes in water using magnetically recoverable Fe(3)O(4) nanoparticles is reported. This methodology results in the synthesis of a variety of 2,3-dihydroquinazolin-4(1H)-ones in high yields. The catalyst can be recovered and recycled without a significant loss in the catalytic activity.
Zhang
Zhan-Hui
ZH
The College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050016, China. zhanhui@mail.nankai.edu.cn
Lü
Hong-Yan
HY
Yang
Shu-Hong
SH
Gao
Jian-Wu
JW
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010078:Oxazines / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D000447:Aldehydes; D000588:Amines; D010078:Oxazines; D052999:Quinazolinones; D014867:Water; C037902:isatoic anhydride; D052203:Ferrosoferric Oxide