title: Oncolytic-adenovirus-expressed RNA interference for cancer therapy.
abstract: BACKGROUND
  RNA interference (RNAi) has generated considerable excitement for its potential cancer therapeutic applications. Because of the difficulties in delivering a large amount of siRNA to cancer cells and the short half-life of siRNA, it is important to choose an efficient delivery system for transduction of siRNA into target cells. Oncolytic adenovirus offers a better platform by virtue of its high transfection efficiency and selective replication in cancer cells.
  
  
  METHODS
  This review focuses on the synergism between oncolytic adenovirus and siRNA antitumor responses, and discusses recent progresses in oncolytic-adenovirus-expressed siRNA.
  
  
  RESULTS
  siRNA-expressing oncolytic adenovirus can generate a significantly enhanced antitumor effect through gene knockdown and viral oncolysis.
  
  
  CONCLUSIONS
  Due to its potency and target specificity, using siRNA delivery by oncolytic adenovirus has generated much excitement and will open new avenues for treatment of human cancer.
authors.affiliation: Xuzhou Medical College, Laboratory of Biological Cancer Therapy, 84 West Huai-hai Road, Xuzhou, Jiangsu 221002, PR China. jnzheng@xzmc.edu.cn
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Pei
authors.forename: Jie-Hui
authors.initials: JH
authors.lastname: Di
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Chen
authors.forename: Jun-Nian
authors.initials: JN
authors.lastname: Zheng
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy* / Q000821:virology; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000235:genetics*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000096:biosynthesis*
chemical_list: D034741:RNA, Small Interfering