title: Survival and disease relapse in surgical stage I endometrioid adenocarcinoma of the uterus after adjuvant vaginal vault brachytherapy.
abstract: BACKGROUND
  Advanced age, deep myoinvasion, whole cavity or lower uterine segment tumors, poor differentiation, and lymphovascular space invasion are known to increase recurrence risk and adversely affect survival in stage I endometrioid adenocarcinoma of the uterus.
  
  
  OBJECTIVE
  To ascertain survival rates, failure patterns, and salvageability and to correlate adverse histopathologic effects to recurrences in these patients.
  
  
  METHODS
  Data of 162 patients with surgical stage I endometrioid adenocarcinoma of the uterus with an increased risk of recurrence were reviewed from the year 1997 to 2008 at KK Gynaecological Cancer Centre, Singapore. Each patient underwent surgical staging and histopathologic evaluation and received high-dose rate vaginal vault brachytherapy. The data of all patients were discussed in a multidisciplinary meeting.
  
  
  RESULTS
  The mean patient age was 58.9 years. Most patients (54.3%) had surgical stage IC endometrioid adenocarcinoma, whereas the rest had stage IB. Grade 2 tumors were seen in 53.7% of the patients and grade 3 in 21.61%. The mean follow-up duration was 52.9 months, with a maximum of 11.5 years. Five- and 10-year survival rates were 94% and 89%, respectively. There were 9 recurrences (5.56%). Stage IC had 77.78% recurrences, whereas stage IB had 22.22%, the median time being 19 months. The initial 3 years had 77.78% relapses. There was no recurrence in grade 3 tumors, with a 100% 5-year survival rate for stage IC grade 3. Age, lymphovascular space invasion, and tumor volume and location were not significant parameters in surgical stage I endometrioid adenocarcinoma patients who failed. One patient had isolated pelvic failure, whereas 5 had a pure distant relapse. Three patients failed at both locoregional and distant sites. Vault recurrence coupled with distant metastasis occurred in 1 patient. Three patients (33.33%) with recurrences, all with limited relapse sites, were salvaged, with a mean survival of 71.33 months. The median survival for recurrent endometrial cancer was 5 years.
  
  
  CONCLUSIONS
  This treatment has excellent survival rates with acceptable morbidity, and recurrence is mostly distant.
authors.affiliation: Department of Gynaecological Oncology, KK Gynaecological Cancer Centre, National Cancer Centre, Singapore, Singapore. drvinitakumar@yahoo.co.in
authors.forename: Vinita Jaggi
authors.initials: VJ
authors.lastname: Kumar
authors.forename: Chia Yin
authors.initials: CY
authors.lastname: Nin
authors.forename: Lim Yong
authors.initials: LY
authors.lastname: Kuei
authors.forename: Khoo H S
authors.initials: KH
authors.lastname: Tan
authors.forename: Richard
authors.initials: R
authors.lastname: Yeo
authors.forename: Philip Yam Kwai
authors.initials: PY
authors.lastname: Lam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D018269:Carcinoma, Endometrioid / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000401:mortality*; D015996:Survival Rate; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery