title: Increased frontoparietal integration after stroke and cognitive recovery.
abstract: The neural mechanism by which patients spontaneously recover cognitive function after brain injury is not understood. Here we demonstrate for the first time that aphasic patients, who have largely recovered language function, show increased frontoparietal integration. A similar change in functional connectivity is also observed when normal subjects are exposed to adverse listening conditions. Thus, compensation for inefficient language processing is associated with increased integration between parts of the language network critical to language control. This change reflects greater top-down control of speech comprehension and provides a mechanism by which language impairments after stroke may be compensated for.
authors.affiliation: Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital Campus, London, UK. david.sharp@imperial.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Sharp
authors.forename: Federico E
authors.initials: FE
authors.lastname: Turkheimer
authors.forename: Subrata K
authors.initials: SK
authors.lastname: Bose
authors.forename: Sophie K
authors.initials: SK
authors.lastname: Scott
authors.forename: Richard J S
authors.initials: RJ
authors.lastname: Wise
mesh_terms: D000328:Adult; D000368:Aged; D001037:Aphasia / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D011877:Radionuclide Imaging; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*