title: Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl].
abstract: New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl(2)] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).
authors.affiliation: Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6.
authors.forename: Shadia A
authors.initials: SA
authors.lastname: Elsayed
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: El-Hendawy
authors.forename: Sahar I
authors.initials: SI
authors.lastname: Mostafa
authors.forename: Bertrand J
authors.initials: BJ
authors.lastname: Jean-Claude
authors.forename: Margarita
authors.initials: M
authors.lastname: Todorova
authors.forename: Ian S
authors.initials: IS
authors.lastname: Butler