Reversible photoswitching of protein function.
Using light to tune the activity of proteins represents a very attractive avenue for creating various temporal interferences in living systems. In this mini-review, we highlight a few recent developments in this broad and exciting field. Among the various methods, we have discussed in more detail the advantages and future challenges in using light switchable drugs to regulate the signaling proteins in the immune system.
Erdmann
Frank
F
Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D-06120, Halle/Saale, Germany.
Zhang
Yixin
Y
D000818:Animals; D005821:Genetic Techniques; D007536:Isomerism; D008027:Light; D004364:Pharmaceutical Preparations / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D011506:Proteins