title: A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor.
abstract: Obesity is a growing global health problem that contributes to diabetes, hypertension, cardiovascular diseases, dementia, and cancer. The increased consumption of saturated fats in a high-fat diet (HFD) contributes to obesity, neurodegenerative diseases, long-term memory loss, and cognitive impairment. We tested whether HFD influences adult hippocampal neurogenesis. Male C57BL/6 mice were divided into two groups and maintained on either a normal diet (ND) or HFD. Seven weeks of HFD significantly decreased the numbers of newly generated cells in the dentate gyrus of the hippocampus without neuronal loss. HFD also increased the level of malondialdehyde (MDA) and decreased the level of brain-derived neurotrophic factor (BDNF) in the hippocampus. The toxic effects of MDA were evaluated on neural progenitor cells (NPCs). MDA reduced the growth of NPCs, but BDNF treatment restored NPCs proliferation. The present data indicate that a HFD impairs hippocampal neurogenesis and NPCs proliferation through increased lipid peroxidation and decreased BDNF.
authors.affiliation: Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong-gu, Busan 609-735, Republic of Korea.
authors.forename: Hee Ra
authors.initials: HR
authors.lastname: Park
authors.forename: Mikyung
authors.initials: M
authors.lastname: Park
authors.forename: Jehun
authors.initials: J
authors.lastname: Choi
authors.forename: Kun-Young
authors.initials: KY
authors.lastname: Park
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
authors.forename: Jaewon
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis*; D004041:Dietary Fats / Q000009:adverse effects*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D009765:Obesity / Q000209:etiology / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004041:Dietary Fats