title: t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa.
abstract: OBJECTIVE
  The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas. We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had the t(11;18)(q21;q21) chromosome translocation.
  
  
  METHODS
  Tumor specimens were examined by light microscopy and immunohistochemistry. To investigate where the present case has API-MALT1 fusion, we used the nested PCR and FISH analysis.
  
  
  RESULTS
  Some colonized lymphoid follicles with mantle zone were observed on low-power field, and centrocyte-like cells and monocytoid B cells were observed on high-power field. Immunohistochemical staining of the tumor was positive for bcl-2, CD20, CD79a, CD43, Lambda, Kappa and was negative for CD10, IgG, IgG4, IgM, cyclin D1, bcl-6, CK (AE1/3), Helicobacter pylori. Using the nested PCR and FISH analysis, present case had the t(11;18)(q21;q21) chromosome translocation (A1446-M1150).
  
  
  CONCLUSIONS
  We report that MALT lymphoma in buccal mucosa has the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) by using the nested PCR and FISH analysis. This is the first report of the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in the oral cavity.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Mituyoshi
authors.initials: M
authors.lastname: Iino
mesh_terms: D000368:Aged; D020169:Caspases / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D005260:Female; D050939:Gene Fusion; D017491:Genes, APC; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D009363:Neoplasm Proteins; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein