title: HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia.
abstract: We studied viral evolution in five human leukocyte antigen (HLA)-B*57 patients recently infected with HIV-1. Escape mutations in HLA-B*57-restricted Gag epitopes were present at study entry in all patients, but were not associated with significant increases in viremia. Conversely, no new escape mutations in HLA-B*57-restricted epitopes or known compensatory mutations were detected in patients who experienced significant increases in viremia. Thus, the development of escape mutations alone does not determine virologic outcome in recently infected HLA-B*57 patients.
authors.affiliation: Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Durand
authors.forename: Karen A
authors.initials: KA
authors.lastname: O'Connell
authors.forename: Linda G
authors.initials: LG
authors.lastname: Apuzzo
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Langan
authors.forename: Hejab
authors.initials: H
authors.lastname: Imteyaz
authors.forename: Aima A
authors.initials: AA
authors.lastname: Ahonkhai
authors.forename: Christina M
authors.initials: CM
authors.lastname: Ceccato
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Williams
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Margolick
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
mesh_terms: D018984:Epitopes, T-Lymphocyte / Q000235:genetics*; D015750:Genes, gag / Q000235:genetics*; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: D018984:Epitopes, T-Lymphocyte; D015235:HLA-B Antigens; C103707:HLA-B57 antigen