title: Severe carbon monoxide poisoning complicated by hypothermia: a case report.
abstract: It is proposed that the significant elevation of interleukin-6 (>400 pg/mL) in cerebrospinal fluid during the early phase of carbon monoxide poisoning may be a predictive biomarker for the development of delayed encephalopathy. A 52-year-old man presented to the emergency department with severe carbon monoxide poisoning. On arrival, the patient was comatose with decorticate rigidity (Glasgow Coma Scale, E1V1M3). His core body temperature, measured in the urinary bladder, was 32.4°C. Laboratory blood analysis revealed elevated CO-Hb (36.0%) and metabolic acidosis with elevated lactate (pH 7.081; base excess [BE], -19.2 mmol/L; HCO3, -9.8 mmol/L; lactate, 168.8 mg/dL). After treatment with hyperbaric oxygen and several different rewarming techniques, he became alert and his core body temperature increased to normal. Interleukin-6 in cerebrospinal fluid at 5.5 hours after his last exposure to carbon monoxide was significantly elevated (752 pg/mL). However, he did not develop delayed encephalopathy. In this case, hypothermia in the range of therapeutic hypothermia (32°C to 34°C) may have suppressed formation of reactive oxygen species and subsequent lipid peroxydation, preventing the development of delayed encephalopathy. Therapeutic hypothermia initiated soon after the last exposure to carbon monoxide may be an effective prophylactic method for preventing the development of delayed encephalopathy.
authors.affiliation: Department of Emergency and Critical Care Medicine, School of Medicine, Kitasato University, Kanagawa 252-0374, Japan. yk119@kitasato-u.ac.jp
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kamijo
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Ide
authors.forename: Ayako
authors.initials: A
authors.lastname: Ide
authors.forename: Kazui
authors.initials: K
authors.lastname: Soma
mesh_terms: D001921:Brain / Q000473:pathology; D002249:Carbon Monoxide Poisoning / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D007035:Hypothermia / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000473:pathology