Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines.
The first organocatalyzed multicomponent domino reactions of aryl ketones, aldehydes and malononitrile were carried out successfully to afford multisubstituted cyclohexa-1,3-dienamines in satisfactory yields.
Wang
Junfeng
J
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, PR China.
Li
Qin
Q
Qi
Chao
C
Liu
Yi
Y
Ge
Zemei
Z
Li
Runtao
R
D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003514:Cyclohexylamines / Q000138:chemical synthesis / Q000737:chemistry*; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*
D000447:Aldehydes; D003514:Cyclohexylamines; D003959:Diamines; D007659:Ketones; D009570:Nitriles; C000945:dicyanmethane