A clock ticks in pancreatic beta cells.
Circadian rhythm is a pervasive feature of life, programmed by the conserved core clock machinery. A recent study in Nature (Marcheva et al., 2010) reveals that core clock components regulate beta cell function and integrate insulin secretion into rhythmic metabolic regulation, providing new insight into the pathogenesis of diabetes.
Yoshino
Jun
J
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Imai
Shin-Ichiro
S