title: Correlation between mammographic and sonographic findings and prognostic factors in patients with node-negative invasive breast cancer.
abstract: OBJECTIVE
  The purpose of this study was to correlate sonographic and mammographic findings with prognostic factors in patients with node-negative invasive breast cancer.
  
  
  METHODS
  Sonographic and mammographic findings in 710 consecutive patients (age range 21-81 years; mean age 49 years) with 715 node-negative invasive breast cancers were retrospectively evaluated. Pathology reports relating to tumour size, histological grade, lymphovascular invasion (LVI), extensive intraductal component (EIC), oestrogen receptor (ER) status and HER-2/neu status were reviewed and correlated with the imaging findings. Statistical analysis was performed using logistic regression analysis and intraclass correlation coefficient (ICC).
  
  
  RESULTS
  On mammography, non-spiculated masses with calcifications were associated with all poor prognostic factors: high histological grade, positive LVI, EIC, HER-2/neu status and negative ER. Other lesions were associated with none of these poor prognostic factors. Hyperdense masses on mammography, the presence of mixed echogenicity, posterior enhancement, calcifications in-or-out of masses and diffusely increased vascularity on sonography were associated with high histological grade and negative ER. Associated calcifications on both mammograms and sonograms were correlated with EIC and HER-2/neu overexpression. The ICC value for the disease extent was 0.60 on mammography and 0.70 on sonography.
  
  
  CONCLUSIONS
  Several sonographic and mammographic features can have a prognostic value in the subsequent treatment of patients with node-negative invasive breast cancer. Radiologists should pay more attention to masses that are associated with calcifications because on both mammography and sonography associated calcifications were predictors of positive EIC and HER-2/neu overexpression.
authors.affiliation: Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan, Songpa-Gu, Seoul, Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Shin
authors.forename: H H
authors.initials: HH
authors.lastname: Kim
authors.forename: M O
authors.initials: MO
authors.lastname: Huh
authors.forename: M J
authors.initials: MJ
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Yi
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: B H
authors.initials: BH
authors.lastname: Son
authors.forename: S H
authors.initials: SH
authors.lastname: Ahn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011859:Radiography; D011960:Receptors, Estrogen; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen