title: Prefrontal Cortex Modulation during Anticipation of Working Memory Demands as Revealed by Magnetoencephalography.
abstract: During the anticipation of task demands frontal control is involved in the assembly of stimulus-response mappings based on current goals. It is not clear whether prefrontal modulations occur in higher-order cortical regions, likely reflecting cognitive anticipation processes. The goal of this paper was to investigate prefrontal modulation during anticipation of upcoming working memory demands as revealed by magnetoencephalography (MEG). Twenty healthy volunteers underwent MEG while they performed a variation of the Sternberg Working Memory (WM) task. Beta band (14-30 Hz) SAM (Synthetic Aperture Magnetometry) analysis was performed. During the preparatory periods there was an increase in beta power (event-related synchronization) in dorsolateral prefrontal cortex (DLPFC) bilaterally, left inferior prefrontal gyrus, left parietal, and temporal areas. Our results provide support for the hypothesis that, during preparatory states, the prefrontal cortex is important for biasing higher order brain regions that are going to be engaged in the upcoming task.
authors.affiliation: Clinical Brain Disorder Branch, NIMH, Bldg. 10, Rm. 4S235, Bethesda, MD 20892, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Altamura
authors.forename: Terry E
authors.initials: TE
authors.lastname: Goldberg
authors.forename: Brita
authors.initials: B
authors.lastname: Elvevåg
authors.forename: Tom
authors.initials: T
authors.lastname: Holroyd
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Carver
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: Richard
authors.initials: R
authors.lastname: Coppola