Side differences of carotid intima-media thickness in predicting cardiovascular events among patients with coronary artery disease.
Population-based studies have demonstrated differences in intima-media thickness (IMT) measured from the left and right common carotid arteries (CCAs). However, its prognostic implications among patients with established coronary artery disease (CAD) remain unknown. Correlations between the left and right CCAs and the composite end point of cardiac death or nonfatal acute coronary syndrome among 149 patients with angiographically confirmed stable CAD were studied. A total of 22 patients had cardiovascular events during the 32.1 ± 10.9 months follow-up. Multivariate analysis revealed that prior ischemic stroke (hazard ratio [HR]: 15.36, 95% confidence interval [CI]: 4.49-52.59, P < .001), extent of CAD (HR: 1.56, 95%CI: 1.01-2.42, P = .046), and right CCA IMT (HR: 17.07, 95%CI: 2.16-134.69, P = .007) but not the left CCA IMT, independently predicted cardiovascular events. The right CCA IMT independently predicted event-free survival among patients with established CAD, suggesting that the left and right CCA may exhibit different prognostic values in our population.
Lee
Stephen Wai-luen
SW
Cardiology Division, Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China.
Hai
Jo Jo Siu Han
JJ
Kong
Shun-ling
SL
Lam
Yui-ming
YM
Lam
Simon
S
Chan
Pak-hei
PH
Chan
Ki-wan
KW
Wong
Ka-lam
KL
Tam
Chor-cheung
CC
Chan
Raymond Hon-wah
RH
D000368:Aged; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography