title: [A new method to explore the modulation from the saccadic system on the pupillary light reflex system].
abstract: The saccadic system has anatomical and functional connections with the pupillary light reflex (PLR) system. But it is not known whether the saccadic system modulates the PLR system. To investigate this issue, it is necessary to understand whether the uneven light stimulus to retina and the near responses influence the change of pupil diameter. We designed a new behavioral method to investigate the issue on human subjects.
  
  
  METHODS
  one eye of the subject was stimulated by pulse light stimulus from a horizontal linear array of light emitting diodes (LEDs) presented across visual field in an ocular mask. The changes of the eye position and pupil diameter of another eye were recorded by an infrared eye tracking system.
  
  
  RESULTS
  The relative constriction ratios of PLRs on the condition that the fixation points of subjects were in the nasal visual field were not significantly different from that the fixation points of subjects were in the temporal visual field(P=0.148, non-paired t test).
  
  
  CONCLUSIONS
  The influences from uneven light stimulus to retina and the near responses were eliminated by this method. The method can be used to study the modulation from the saccadic system on the pupillary light reflex system.
authors.affiliation: Laboratory of Sensory-motor Integration Research, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China. chenzuyue@gmail.com
authors.forename: Zu-Yue
authors.initials: ZY
authors.lastname: Chen
authors.forename: Ying-Zhou
authors.initials: YZ
authors.lastname: Hu
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Zhang
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Jiang
authors.forename: Xin-Tian
authors.initials: XT
authors.lastname: Hu
mesh_terms: D005123:Eye / Q000528:radiation effects; D006801:Humans; D008027:Light; D010775:Photic Stimulation; D011680:Pupil / Q000502:physiology / Q000528:radiation effects*; D012018:Reflex; D012025:Reflex, Pupillary / Q000528:radiation effects*; D014785:Vision, Ocular / Q000502:physiology / Q000528:radiation effects*; D014794:Visual Fields / Q000502:physiology / Q000528:radiation effects