Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates.
We present a novel nanoparticle building block system based on the interactions between short synthetic oligonucleotides and peptides. Gold nanoparticles coated with DNA-binding peptides can be attached to self-organized oligonucleotide templates to formulate well-ordered structures of nanoparticles. By regulating the amount of DNA-binding peptide attached to the nanoparticle surface and using specifically designed oligonucleotides, the nanoparticle assembly can be controlled to form dimers, trimers, and adjustable-length nanoparticle chains as well as more complex structures.
Coomber
Danielle
D
School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ, UK.
Bartczak
Dorota
D
Gerrard
Simon R
SR
Tyas
Sarah
S
Kanaras
Antonios G
AG
Stulz
Eugen
E
D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D013499:Surface Properties
D009841:Oligonucleotides; D010455:Peptides; D006046:Gold; D004247:DNA