Curvularides A-E: antifungal hybrid peptide-polyketides from the endophytic fungus Curvularia geniculata.
Five new hybrid peptide-polyketides, curvularides A-E (1-5), were isolated from the endophytic fungus Curvularia geniculata, which was obtained from the limbs of Catunaregam tomentosa. Structure elucidation for curvularides A-E (1-5) was accomplished by analysis of spectroscopic data, as well as by single-crystal X-ray crystallography. Curvularide B (2) exhibited antifungal activity against Candida albicans, and it also showed synergistic activity with a fluconazole drug.
Chomcheon
Porntep
P
Program of Biotechnology, Faculty of Science, Chandrakasem Rajabhat University, Bangkok, 10900 Thailand.
Wiyakrutta
Suthep
S
Aree
Thammarat
T
Sriubolmas
Nongluksna
N
Ngamrojanavanich
Nattaya
N
Mahidol
Chulabhorn
C
Ruchirawat
Somsak
S
Kittakoop
Prasat
P
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000737:chemistry* / Q000302:isolation & purification; D002678:Chimera / Q000378:metabolism; D018360:Crystallography, X-Ray; D015725:Fluconazole / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D010455:Peptides; C554505:curvularide B; D015725:Fluconazole