Oxaliplatin-induced acute thrombocytopenia.
We describe a patient who experienced immediate onset severe thrombocytopenia as part of a hypersensitivity reaction to oxaliplatin, following substantial relatively uncomplicated previous exposure to the drug. We review other reports of acute hematological toxicity from oxaliplatin. We draw attention to the important need for vigilance when patients develop unusual acute symptoms during or shortly after oxaliplatin infusion.
Mason
Jessica M
JM
Bristol Haematology and Oncology Centre, Horfield Road, Bristol, BS2 8ED, UK.
Rees
Gareth Jg
GJ
D000208:Acute Disease; D000368:Aged; D006801:Humans; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis*
D009944:Organoplatinum Compounds; D000077150:Oxaliplatin