title: Recurrence after treatment for pulmonary multidrug-resistant tuberculosis.
abstract: We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness-that all 16 episodes were caused by the original tuberculosis strain-then 5.2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve.
authors.affiliation: Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA. mbecerra@post.harvard.edu
authors.forename: Mercedes C
authors.initials: MC
authors.lastname: Becerra
authors.forename: Sasha C
authors.initials: SC
authors.lastname: Appleton
authors.forename: Molly F
authors.initials: MF
authors.lastname: Franke
authors.forename: Katiuska
authors.initials: K
authors.lastname: Chalco
authors.forename: Jaime
authors.initials: J
authors.lastname: Bayona
authors.forename: Megan B
authors.initials: MB
authors.lastname: Murray
authors.forename: Carole D
authors.initials: CD
authors.lastname: Mitnick
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D010568:Peru / Q000453:epidemiology; D012008:Recurrence; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology*
chemical_list: D000995:Antitubercular Agents