title: [Influence of oncological treatment on fertility of women and pregnancy outcome].
abstract: Advances in cancer treatment of young patients have resulted in markedly improved survival rates and quality of life. However infertility remains to be one of adverse effects of anticancer therapy. Female patients who receive high-dose abdominal and/or pelvic irradiation or chemotherapy based on alkylating agents are at highest risk of developing ovarian failure. Among women whose fertility was not impaired during oncologic treatment, there is a significantly increased number of premature labors. High-dose irradiation also predisposes to low-birthweight infants. Neither chemotherapy nor radiotherapy increase a risk of congenital malformations.
authors.affiliation: Klinika Perinatologii i Chorób Kobiecych UM im. Karola Marcinkowskiego w Poznaniu. annamarkowska@vp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Markowska
authors.forename: Monika
authors.initials: M
authors.lastname: Pawałowska
authors.forename: Janina
authors.initials: J
authors.lastname: Markowska
authors.forename: Maria
authors.initials: M
authors.lastname: Litwiniuk
authors.forename: Radosław
authors.initials: R
authors.lastname: Madry
authors.forename: Darah
authors.initials: D
authors.lastname: Dilmaghani-Tabriz
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000139:chemically induced / Q000209:etiology*; D009369:Neoplasms / Q000628:therapy*; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000517:prevention & control; D011256:Pregnancy Outcome; D011832:Radiation Injuries / Q000150:complications; D011878:Radiotherapy / Q000009:adverse effects*; D018456:Reproductive Medicine; D027724:Reproductive Techniques, Assisted; D014599:Uterus / Q000187:drug effects / Q000528:radiation effects; D016387:Women's Health
chemical_list: D000970:Antineoplastic Agents