Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.
In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-Ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirm that the "small molecule" co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.
Nagorny
Pavel
P
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, Laboratory for Bioorganic Chemistry.
Krauss
Isaac
I
Njardarson
Jón T
JT
Perez
Lucy
L
Gaul
Christoph
C
Yang
Guangli
G
Ouerfelli
Ouathek
O
Danishefsky
Samuel J
SJ