title: Diagnostic precision of CT in local staging of colon cancers: a meta-analysis.
abstract: OBJECTIVE
  To determine the accuracy of computed tomography (CT) in detecting disease with invasion beyond the muscularis propria (MP) and malignant lymph nodes.
  
  
  METHODS
  A literature search of Ovid, Embase, the Cochrane database, and Medline using Pubmed, Google Scholar and Vivisimo search engines was performed to identify studies reporting on the accuracy of CT to predict the staging of colonic tumours. Publication bias was demonstrated by Funnel plots. The sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated using a bivariate random effects model and hierarchical summary operating curves (HSROC) were generated.
  
  
  RESULTS
  Nineteen studies fulfilled all the necessary inclusion criteria. The pooled sensitivity, specificity, DOR for detection of tumour invasion were 86% (95% CI: 78-92%); 78% (95% CI: 71-84%); 22.4 (95% CI: 11.9-42.4). Similarly, the values for nodal detection were 70% (95% CI: 63-73%); 78% (95% CI: 73-82%); 8.1(95% CI: 4.7-14.1). In the subgroup analysis, the best results were obtained in studies utilizing multidetector CT (MDCT).
  
  
  CONCLUSIONS
  Preoperative staging CT accurately distinguishes between tumours confined to the bowel wall and those invading beyond the MP; however, it is significantly poorer at identifying nodal status. MDCT provides the best results.
authors.affiliation: Department of Radiology, Royal Marsden Hospital, Sutton, UK.
authors.forename: S
authors.initials: S
authors.lastname: Dighe
authors.forename: S
authors.initials: S
authors.lastname: Purkayastha
authors.forename: I
authors.initials: I
authors.lastname: Swift
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
authors.forename: A
authors.initials: A
authors.lastname: Darzi
authors.forename: R
authors.initials: R
authors.lastname: A'Hern
authors.forename: G
authors.initials: G
authors.lastname: Brown
mesh_terms: D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D016017:Odds Ratio; D014057:Tomography, X-Ray Computed / Q000592:standards*