Reversible dysfunction of receptors in traumatic brain injury?
In many brain disorders reduced binding of central benzodiazepine receptor ligands indicates irreversible neuronal damage. The data presented by Koizumi et al (2010) demonstrate that this is not the case in traumatic brain injury suggesting different pathogenetic mechanisms leading to tissue damage. The proof for this hypothesis requires further studies that should also consider thresholds of ligand binding as indicators of irreversible damage.
Heiss
Wolf-Dieter
WD
Max Planck Institute for Neurological Research, Cologne, Germany. wdh@nf.mpg.de
D001930:Brain Injuries / Q000175:diagnosis* / Q000473:pathology; D005442:Flumazenil / Q000031:analogs & derivatives; D006801:Humans; D007457:Iodine Radioisotopes; D009474:Neurons / Q000473:pathology*; D011963:Receptors, GABA-A / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil