Escorts take the lead molecular chaperones as therapeutic targets.
The functional and physiological diversity of transmembrane receptors results from factors that influence the pharmacology, signaling, and trafficking of these receptors. Receptor mutations and other modifications may lead to misfolding, intracellular retention, and ineffective signaling of transmembrane receptors. The importance of such mutations is highlighted by the fact that various diseases have been linked to mutations that lead to ineffective signaling of these receptors, resulting from the retention of receptors in intracellular compartments. Studies focused on understanding the regulation of trafficking and cell surface expression of newly synthesized receptors have highlighted molecular chaperones as key regulators of receptor maturation and sorting. In this chapter, we discuss the functions of molecular chaperones in the regulation of seven-transmembrane-containing G-protein-coupled receptor function and trafficking and explore ways in which chaperones can serve as novel therapeutic targets.
Williams
Dumaine
D
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA.
Devi
Lakshmi A
LA
D000818:Animals; D055808:Drug Discovery; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000187:drug effects* / Q000378:metabolism*; D020836:Protein Structure, Quaternary; D021381:Protein Transport; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D018832:Molecular Chaperones; D043562:Receptors, G-Protein-Coupled