title: Resveratrol attenuates radiation damage in Caenorhabditis elegans by preventing oxidative stress.
abstract: Resveratrol, a member of a class of polyphenolic compounds known as flavonols, has been extensively studied for its anticancer, antiviral, anti-inflammatory, and neuroprotective roles. Caenorhabidits elegans is a well-established animal for investigating responses to radiation. We found that resveratrol may provide protection against hazardous radiation. Pre-treatment with resveratrol extended both the maximum and mean life span of irradiated C. elegans. Resveratrol acted as a strong radical scavenger and regulated superoxide dismutase (SOD) expression. In addition, resveratrol was shown to be capable of alleviating gamma-ray radiation exposure-induced reduction in mitochondrial SOD expression. Ultimately, a correlation may exist between dietary intake of trace amounts of resveratrol and anti-aging effects. A specific response mechanism may be activated after the administration of resveratrol in irradiated animals. Our results suggest the protective effect of resveratrol is due to its strong ability to protect from oxidative stress and protective effects in mitochondria. Therefore, resveratrol is potentially an effective protecting agent against irradiative damage.
authors.affiliation: School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou 215123, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Ye
authors.forename: Chen-Bo
authors.initials: CB
authors.lastname: Ji
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Lu
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Ni
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Gao
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Chen
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Zhao
authors.forename: Gui-Xiong
authors.initials: GX
authors.lastname: Gu
authors.forename: Xi-Rong
authors.initials: XR
authors.lastname: Guo
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D000975:Antioxidants / Q000494:pharmacology; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers / Q000235:genetics; D018509:DNA, Helminth / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D016166:Free Radical Scavengers / Q000494:pharmacology; D005720:Gamma Rays / Q000009:adverse effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D018384:Oxidative Stress / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D029742:Caenorhabditis elegans Proteins; D017931:DNA Primers; D018509:DNA, Helminth; D004272:DNA, Mitochondrial; D016166:Free Radical Scavengers; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D013267:Stilbenes; D013482:Superoxide Dismutase; C507014:SIR-2.1 protein, C elegans; D037761:Sirtuins; D000077185:Resveratrol