Fiber-optic probes for in vivo depth-resolved neuron-activity mapping.
Specialty fiber probes are used for in vivo depth-resolved mapping of neuron activity through the optical detection of fluorescent-protein reporters expressed inside the living brain of anesthetized transgenic mice. Supercontinuum radiation produced by highly nonlinear photonic-crystal fibers is employed to demonstrate a simultaneous multicolor interrogation of several biomarkers in a model aqueous solution system, thus suggesting the way toward a multiplex mapping of various types of neuron dynamics inside the living brain.
Doronina-Amitonova
Lyubov V
LV
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Russia.
Fedotov
Il'ya V
IV
Ivashkina
Olga I
OI
Zots
Marina A
MA
Fedotov
Andrei B
AB
Anokhin
Konstantin V
KV
Zheltikov
Aleksei M
AM
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000166:cytology / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D057054:Molecular Imaging / Q000295:instrumentation*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D055100:Optical Fibers; D055620:Optical Phenomena; D017785:Photons
D015415:Biomarkers; D049452:Green Fluorescent Proteins