title: Does C-reactive protein predict recurrent preeclampsia?
abstract: OBJECTIVE
  Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia.
  
  
  METHODS
  Serum samples collected longitudinally in women with previous preeclampsia from the Maternal-Fetal Medicine Units Network trial of aspirin to prevent preeclampsia were assayed for CRP.
  
  
  RESULTS
  Of 255 women studied, 50 developed recurrence. Baseline C-reactive protein concentration was similar between women who did and did not recur. After adjusting for confounders, neither elevated baseline C-reactive protein nor its change over gestation was associated with recurrence.
  
  
  CONCLUSIONS
  In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA, USA. hgammill@u.washington.edu
authors.forename: Hilary S
authors.initials: HS
authors.lastname: Gammill
authors.forename: Robert W
authors.initials: RW
authors.lastname: Powers
authors.forename: Rebecca G
authors.initials: RG
authors.lastname: Clifton
authors.forename: J Peter
authors.initials: JP
authors.lastname: Van Dorsten
authors.forename: Mark A
authors.initials: MA
authors.lastname: Klebanoff
authors.forename: Marshall D
authors.initials: MD
authors.lastname: Lindheimer
authors.forename: Baha
authors.initials: B
authors.lastname: Sibai
authors.forename: Mark B
authors.initials: MB
authors.lastname: Landon
authors.forename: Menachem
authors.initials: M
authors.lastname: Miodovnik
authors.forename: Mitchell
authors.initials: M
authors.lastname: Dombrowski
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012008:Recurrence; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein