title: Cutaneous leishmaniasis in a child treated with oral fluconazole.
abstract: We report a case of cutaneous leishmaniasis in a 3-year-old West African girl with a 3-month history of multiple disfiguring, infiltrated, ulcerating and variably necrotic granulomatous plaques on the limbs and face that occurred after swimming in a river approximately 6 weeks before arriving in Australia. A diagnosis of cutaneous leishmaniasis, a protozoal zoonosis usually transmitted by the Phlebotomus species of sandfly, was considered. The clinico-pathological features were consistent with Leishmania major infection, known to be the major endemic species causing cutaneous leishmaniasis in the country of origin. Because of the presence of lesions on the face, active treatment was instituted. Continuing resolution of all lesions over 6 weeks was noted to occur with cribiform scarring with the use of oral fluconazole 150 mg daily. Oral fluconazole appears to be emerging as a therapy for uncomplicated cutaneous leishmaniasis, with advantages particularly important in paediatrics.
authors.affiliation: Royal Newcastle Centre Department of Dermatology, Rankin Park, NSW, Australia. asklavos@student.usyd.edu.au
authors.forename: Angelo V
authors.initials: AV
authors.lastname: Sklavos
authors.forename: Tony
authors.initials: T
authors.lastname: Walls
authors.forename: Murray T
authors.initials: MT
authors.lastname: Webber
authors.forename: Alan B
authors.initials: AB
authors.lastname: Watson
mesh_terms: D000284:Administration, Oral; D002506:Cephalexin / Q000627:therapeutic use; D002675:Child, Preschool; D002921:Cicatrix / Q000188:drug therapy; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D018320:Leishmania major / Q000187:drug effects; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D015725:Fluconazole; D002506:Cephalexin