title: Outbreak of vim-1-carbapenemase-producing Enterobacter cloacae in a pediatric intensive care unit.
abstract: Pediatric patients are rarely infected with metallo-β-lactamase-producing Enterobacteriaceae. We describe 3 cases of children infected with VIM-1-producing clonal Enterobacter cloacae. Patients were treated with amikacin and cotrimoxazole. The blaVIM-1 gene was carried into a class 1 integron and an IncHI2 incompatibility group plasmid. Emergence of pediatric infections caused by carbapenemases-producing Enterobacteriaceae is a critical issue as they are resistant to most β-lactam antibiotics.
authors.affiliation: Bacteriology Service, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. jesus.oteo@isciii.es
authors.forename: Jesús
authors.initials: J
authors.lastname: Oteo
authors.forename: José Luis
authors.initials: JL
authors.lastname: Hernández-Almaraz
authors.forename: Javier
authors.initials: J
authors.lastname: Gil-Antón
authors.forename: Ana
authors.initials: A
authors.lastname: Vindel
authors.forename: Sara
authors.initials: S
authors.lastname: Fernández
authors.forename: Verónica
authors.initials: V
authors.lastname: Bautista
authors.forename: José
authors.initials: J
authors.lastname: Campos
mesh_terms: D000583:Amikacin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002648:Child; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D016972:Enterobacter cloacae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D032023:Integrons; D015278:Intensive Care Units, Pediatric; D008297:Male; D010957:Plasmids; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000583:Amikacin; C417264:VIM-1 metallo-beta-lactamase; D001618:beta-Lactamases