MACC1 as a marker for advanced colorectal carcinoma.
BACKGROUND
Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases.


METHODS
We analyzed MACC1 expression levels in 52 colorectal cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR).


RESULTS
We found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.042) and higher stage of TNM classification (p=0.007).


CONCLUSIONS
These results suggest that MACC1 is more frequently expressed in advanced colorectal carcinomas.
Shirahata
Atsushi
A
Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.
Shinmura
Kazuki
K
Kitamura
Youhei
Y
Sakuraba
Kazuma
K
Yokomizo
Kazuaki
K
Goto
Tetsuhiro
T
Mizukami
Hiroki
H
Saito
Mitsuo
M
Ishibashi
Kazuyoshi
K
Kigawa
Gaku
G
Nemoto
Hiroshi
H
Hibi
Kenji
K
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015534:Trans-Activators; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D014408:Biomarkers, Tumor; C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors