[The clinical characteristics of hepatic failure with aspergillosis].
OBJECTIVE
To study the clinical characteristics of hepatic failure with aspergillosis.


METHODS
The data of hepatic failure patients with fungal infection hospitalized in our hospital form January 1985 to June 2006 were collected. This research mainly focused on the clinical characteristics of the patients co-infected with aspergillosis.


RESULTS
The occurrence of aspergillosis was 20.5% (104 cases) among 507 hepatic failure patients with fungal infection. Compared with other fungal infection in hepatic failure patients, the effective rate of antifungal therapy and the improvement rate of underlying disease were worse in patients with aspergillus infection (36.5% vs 57.8%, P = 0.000; 26.0% vs 36.7%, P = 0.049). Aspergillus fumigatus was the most common species among 108 fungal species. The species next to Aspergillus fumigatus were Aspergillus niger and Aspergillus flavus. The mainly infected organ was lung and its clinical manifestation was atypical. Liver function could be improved with effective anti-fungus therapy.


CONCLUSIONS
Diagnosis and treatment of aspergillosis is difficult in hepatic failure patients co-infected with aspergillosis. Early and effective antifungal therapy is helpful to the recovery of liver function in the hepatic failure patients suspected with aspergillosis co-infection.
Su
Hai-Bin
HB
Liver Failure Treatment and Research Center, the 302 Hospital of the PLA, Beijing 100039, China.
Wang
Hui-Fen
HF
Yan
Tao
T
Lin
Fang
F
Zhao
Hong
H
Li
Lei
L
Mu
Jin-Song
JS
Li
Chen
C
Xu
Hai-Miao
HM
D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy*; D001230:Aspergillus / Q000302:isolation & purification; D006801:Humans; D017093:Liver Failure / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*
D000935:Antifungal Agents