High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer.
BACKGROUND
The purpose of this study was to evaluate the association between preoperative plasma fibrinogen levels on clinicopathologic parameters and overall survival in patients after curative resection with colorectal cancer.


METHODS
Preoperative plasma fibrinogen levels were examined in 341 patients who underwent curative resection for colorectal cancer. Preoperative plasma fibrinogen levels were correlated with clinicopathologic findings and disease-specific overall survival.


RESULTS
Mean (±SD) preoperative plasma fibrinogen levels were 369.9 mg/dl (±69.1 mg/dl). Elevated plasma fibrinogen levels were associated with advanced tumor stage (P = 0.008), venous invasion (P = 0.006), and postoperative distant metastases (P < 0.001), but not with histologic grade (P = 0.232), invasion depth (P = 0.253), and lymph node involvement (P = 0.136). Multivariate analysis showed that preoperative plasma fibrinogen levels (P = 0.029), histologic grade (P = 0.001), and lymph node involvement (P = 0.001) were defined as independent prognostic factors.


CONCLUSIONS
High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer.
Tang
Liang
L
Colorectal Cancer Surgery Division, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin, China.
Liu
Kai
K
Wang
Junfeng
J
Wang
Cui
C
Zhao
Peng
P
Liu
Jianzhong
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
D014408:Biomarkers, Tumor; D005340:Fibrinogen