title: Antifungal activity of triterpenoid isolated from Azima tetracantha leaves.
abstract: The present study was designed to evaluate the antifungal activity of Azima tetracantha extracts and isolated compound (friedelin) against fungi. Antifungal activity was carried out using broth microdilution method and fractions were collected using (silica gel) column chromatography. The antifungal activity of Azima tetracantha crude extracts and isolated compound (friedelin) were evaluated using the micro dilution method. Hexane extract showed some antifungal activity. The compound also exhibited antifungal activity against tested fungi. The lowest MIC against Trichophyton rubrum (296) was 62.5 microg/ml and the MIC for Curvularia lunata was 62.5 microg/ml. These results suggest that Friedelin is a promising antifungal agent.
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai-34, India.
authors.forename: V
authors.initials: V
authors.lastname: Duraipandiyan
authors.forename: M
authors.initials: M
authors.lastname: Gnanasekar
authors.forename: S
authors.initials: S
authors.lastname: Ignacimuthu
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D032121:Salvadoraceae / Q000033:anatomy & histology / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology; D000094042:Lupanes
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D014315:Triterpenes; C060796:friedelin; D000094042:Lupanes