title: In vitro oral biofilm formation on triclosan-coated sutures in the absence and presence of additional antiplaque treatment.
abstract: OBJECTIVE
  This study evaluated the in vitro plaque inhibitory effect of triclosan-coated polyglactin 910 sutures in the absence and presence of an additional antiplaque agent commonly used after oral surgery.
  
  
  METHODS
  Triclosan-coated sutures were incubated for 4 hours in freshly collected human saliva and, when appropriate, subsequently treated with an antiplaque rinse containing chlorhexidine-cetyl pyridinium as active components. Sutures without a triclosan-coating served as a control.
  
  
  RESULTS
  Triclosan-coated sutures harbored similar amounts of plaque as did uncoated sutures. Exposure to the antiplaque rinse caused significant decreases in viable organisms for uncoated and triclosan-coated sutures. However, after application of the antiplaque rinse, more micro-organisms were found on triclosan-coated than on uncoated sutures.
  
  
  CONCLUSIONS
  Sutures coated with triclosan do not provide a sufficient antimicrobial effect to prevent in vitro colonization by oral bacteria, whereas use in combination with a chlorhexidine-cetyl pyridinium-containing antiplaque rinse appears to be counterproductive.
authors.affiliation: Academic Centre for Oral Health, Department of Periodontology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Venema
authors.forename: Frank
authors.initials: F
authors.lastname: Abbas
authors.forename: Betsy
authors.initials: B
authors.lastname: van de Belt-Gritter
authors.forename: Henny C
authors.initials: HC
authors.lastname: van der Mei
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Busscher
authors.forename: Chris G
authors.initials: CG
authors.lastname: van Hoogmoed
mesh_terms: D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000627:therapeutic use*; D058491:Bacterial Load; D001431:Bacteriological Techniques; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D002594:Cetylpyridinium / Q000008:administration & dosage / Q000627:therapeutic use; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000627:therapeutic use*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects; D008297:Male; D008422:Materials Testing; D050296:Microbial Viability / Q000187:drug effects; D009067:Mouthwashes / Q000627:therapeutic use; D011098:Polyglactin 910 / Q000737:chemistry; D012463:Saliva / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D034361:Streptococcus mitis / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects; D013298:Streptococcus sanguis / Q000187:drug effects; D013537:Sutures; D014260:Triclosan / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D020099:Coated Materials, Biocompatible; D009067:Mouthwashes; D011098:Polyglactin 910; D014260:Triclosan; D002594:Cetylpyridinium; D002710:Chlorhexidine