Bone grafting by means of a tunnel dissection: predictable results using stem cells and matrix.
Bone marrow aspirate has been shown to add stem cells, growth factors, and cytokines to bone graft matrices used in bone augmentation sites. The combination of bone marrow aspirate and resorbable scaffold material has a significant osteogenic capability that exceeds that of autogenous bone grafts. This article describes a subperiosteal tunneling technique for applying such grafts to defective sites. Treatment of 2 patients for whom the technique was used to graft 6 deficient sites is described. Histological results and histomorphometric analysis of bone core samples taken from 4 of the 6 grafting sites are also reported. Analysis of the 4 bone cores taken between 4 and 6 months showed a range of 34% to 45% of new bone.
Soltan
Muna
M
soltandds@aol.com
Smiler
Dennis
D
Soltan
Christine
C
Prasad
Hari S
HS
Rohrer
Michael D
MD
D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods; D001672:Biocompatible Materials / Q000627:therapeutic use; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000379:methods*; D001857:Bone Matrix / Q000637:transplantation*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004210:Dissection / Q000379:methods*; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D010521:Periosteum / Q000601:surgery; D013524:Surgical Flaps; D054457:Tissue Scaffolds; D020858:Tissue and Organ Harvesting / Q000379:methods*; D016896:Treatment Outcome
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D015921:Dental Implants; C485817:beta-tricalcium phosphate; D017886:Durapatite