title: [Genetic basis for skeletal disease. Orthopaedic intervention for bone dysplasias].
abstract: The aims of orthopaedic intervention for bone dysplasias are to maintain joint function, to prevent neurological complications, and then to improve the patient's quality of life. Bone lengthening technique can not only increase the body height, but also correct malalignment of the limb at the same treatment session, which is important to prevent early occurrence of the degenerative osteoarthritis. Intramedullary nailing for osteogenesis imperfecta protects long bones from fractures and prevents malunion when fracture takes place. Spinal instrumentation surgery is effective for prevention of the neurological complications and deterioration of the spinal deformities.
authors.affiliation: Department of Orthopaedic Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Kawabata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugita
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamawaki
mesh_terms: D001848:Bone Diseases, Developmental / Q000628:therapy*; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D009984:Orthopedic Fixation Devices; D019637:Orthopedic Procedures; D010003:Osteoarthritis / Q000209:etiology / Q000517:prevention & control; D011788:Quality of Life