Porcine peritoneum as source of biocompatible collagen in mice.
OBJECTIVE
To investigate the biocompatibility and biodegradability of a membrane made from porcine peritoneum.


METHODS
The membrane (5x5 mm) was inserted in the subcutaneous tissue on the back of 15 mice, which were killed after 1, 3 and 9 weeks (ISO 10993-6). The cellular components of the inflammatory response and degradation of the membrane were analyzed in hematoxylin-eosin-stained histological sections.


RESULTS
After one week, mononuclear cells were observed inside the membrane. After three weeks, the material was almost completely absorbed. After nine weeks, there was no presence of material and there were signs of tissue remodeling. There was neither a foreign body reaction nor signs of tissue necrosis.


CONCLUSIONS
The collagen membrane derived from porcine peritoneum is biocompatible and bioabsorbable when implanted in the subcutaneous tissue of mice.
Jardelino
Cristina
C
Program in Dentistry, Dental School, UFF, Rio de Janeiro, Brazil.
Takamori
Esther Rieko
ER
Hermida
Luiz Felipe
LF
Lenharo
Ariel
A
Castro-Silva
Igor Iuco
II
Granjeiro
Jose Mauro
JM
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics*; D003094:Collagen / Q000032:analysis / Q000493:pharmacokinetics*; D048091:Guided Tissue Regeneration / Q000379:methods*; D008422:Materials Testing; D008567:Membranes, Artificial; D051379:Mice; D010537:Peritoneum / Q000737:chemistry; D040521:Subcutaneous Tissue / Q000502:physiology*; D013552:Swine; D013997:Time Factors
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D003094:Collagen