title: Effects of mobile phone use on brain tissue from the rat and a possible protective role of vitamin C - a preliminary study.
abstract: OBJECTIVE
  To evaluate effects of mobile phone use on brain tissue and a possible protective role of vitamin C.
  
  
  METHODS
  Forty female rats were divided into four groups randomly (Control, mobile phone, mobile phone plus vitamin C and, vitamin C alone). The mobile phone group was exposed to a mobile phone signal (900 MHz), the mobile phone plus vitamin C group was exposed to a mobile phone signal (900 MHz) and treated with vitamin C administered orally (per os). The vitamin C group was also treated with vitamin C per os for four weeks. Then, the animals were sacrificed and brain tissues were dissected to be used in the analyses of malondialdehyde (MDA), antioxidant potential (AOP), superoxide dismutase, catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase, adenosine deaminase (ADA) and 5'nucleotidase (5'-NT).
  
  
  RESULTS
  Mobile phone use caused an inhibition in 5'-NT and CAT activities as compared to the control group. GSH-Px activity and the MDA level were also found to be reduced in the mobile phone group but not significantly. Vitamin C caused a significant increase in the activity of GSH-Px and non-significant increase in the activities of 5'-NT, ADA and CAT enzymes.
  
  
  CONCLUSIONS
  Our results suggest that vitamin C may play a protective role against detrimental effects of mobile phone radiation in brain tissue.
authors.affiliation: Department of Biochemistry, Ankara University Faculty of Medicine, Turkey. imgeerguder@yahoo.com
authors.forename: Ergüder B
authors.initials: EB
authors.lastname: Imge
authors.forename: Bülent
authors.initials: B
authors.lastname: Kiliçoğlu
authors.forename: Erdinç
authors.initials: E
authors.lastname: Devrim
authors.forename: Recep
authors.initials: R
authors.lastname: Cetin
authors.forename: Ilker
authors.initials: I
authors.lastname: Durak
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D002374:Catalase / Q000378:metabolism; D040421:Cell Phone; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D023421:Models, Animal; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011846:Radio Waves / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011837:Radiation-Protective Agents; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D001205:Ascorbic Acid