title: Homebase behavior of zebrafish in novelty-based paradigms.
abstract: Zebrafish (Danio rerio) are emerging as a promising model species in neuroscience research. Many traditional rodent behavioral paradigms may be adapted for zebrafish testing. Exposing zebrafish to three different "open field" tanks for 30 min, we showed that fish display robust homebase behavior, in which one area of the tank is chosen as a preferred point of reference during the test, which the fish frequently return to and spend a longer duration in. This phenotype strikingly resembles rodent homebase behavior, confirming that both species use homebases as "reference points" for their exploration. Our study introduces a simple method for zebrafish homebase phenotyping, and further supports the utility of these fish in neurobehavioral and cognitive research.
authors.affiliation: Department of Pharmacology, Zebrafish Neuroscience Research Consortium, Tulane University Medical School, 1430 Tulane Ave, New Orleans, LA 70112, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Stewart
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cachat
authors.forename: Keith
authors.initials: K
authors.lastname: Wong
authors.forename: Siddharth
authors.initials: S
authors.lastname: Gaikwad
authors.forename: Thomas
authors.initials: T
authors.lastname: Gilder
authors.forename: John
authors.initials: J
authors.lastname: DiLeo
authors.forename: Katie
authors.initials: K
authors.lastname: Chang
authors.forename: Eli
authors.initials: E
authors.lastname: Utterback
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000502:physiology; D015027:Zebrafish / Q000502:physiology*