title: Corrosion resistance and in vitro response of laser-deposited Ti-Nb-Zr-Ta alloys for orthopedic implant applications.
abstract: While direct metal deposition of metallic powders, via laser deposition, to form near-net shape orthopedic implants is an upcoming and highly promising technology, the corrosion resistance and biocompatibility of such novel metallic biomaterials is relatively unknown and warrants careful investigation. This article presents the results of some initial studies on the corrosion resistance and in vitro response of laser-deposited Ti-Nb-Zr-Ta alloys. These new generation beta titanium alloys are promising due to their low elastic modulus as well as due the fact that they comprise of completely biocompatible alloying elements. The results indicate that the corrosion resistance of these laser-deposited alloys is comparable and in some cases even better than the currently used commercially-pure (CP) titanium (Grade 2) and Ti-6Al-4V ELI alloys. The in vitro studies indicate that the Ti-Nb-Zr-Ta alloys exhibit comparable cell proliferation but enhanced cell differentiation properties as compared with Ti-6Al-4V ELI.
authors.affiliation: Department of Materials Science and Engineering, University of North Texas, Denton, Texas, USA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Samuel
authors.forename: Soumya
authors.initials: S
authors.lastname: Nag
authors.forename: Seifollah
authors.initials: S
authors.lastname: Nasrazadani
authors.forename: Vaishali
authors.initials: V
authors.lastname: Ukirde
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Bouanani
authors.forename: Arunesh
authors.initials: A
authors.lastname: Mohandas
authors.forename: Kytai
authors.initials: K
authors.lastname: Nguyen
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D001842:Bone and Bones / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D004566:Electrodes; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D009556:Niobium / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013635:Tantalum / Q000737:chemistry; D013816:Thermodynamics; D014025:Titanium / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry
chemical_list: D000497:Alloys; D028561:Transition Elements; D009556:Niobium; D013635:Tantalum; D015040:Zirconium; D014025:Titanium