Practical iron-catalyzed dehalogenation of aryl halides.
An operationally simple iron-catalyzed hydrodehalogenation of aryl halides has been developed with 1 mol% Fe(acac)(3) and commercial t-BuMgCl as reductant. The mild reaction conditions (THF, 0 degrees C, 1.5 h) effect rapid chemoselective dehalogenation of (hetero)aryl halides (I, Br, Cl) and tolerate F, Cl, OR, SR, CN, CO(2)R, and vinyl groups.
Czaplik
Waldemar Maximilian
WM
Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Koeln, Germany.
Grupe
Sabine
S
Mayer
Matthias
M
Jacobi von Wangelin
Axel
A
D002384:Catalysis; D005290:Ferric Compounds / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D005290:Ferric Compounds; D006841:Hydrocarbons, Aromatic; D006846:Hydrocarbons, Halogenated