title: Androgen excess down-regulates connexin43 in a human granulosa cell line.
abstract: By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.
authors.affiliation: Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Cheng-Hsuan
authors.initials: CH
authors.lastname: Wu
authors.forename: Jyuer-Ger
authors.initials: JG
authors.lastname: Yang
authors.forename: Jiann-Jou
authors.initials: JJ
authors.lastname: Yang
authors.forename: Yueh-Min
authors.initials: YM
authors.lastname: Lin
authors.forename: Hong-Der
authors.initials: HD
authors.lastname: Tsai
authors.forename: Ching-Yuang
authors.initials: CY
authors.lastname: Lin
authors.forename: Pao-Lin
authors.initials: PL
authors.lastname: Kuo
mesh_terms: D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000728:Androgens / Q000494:pharmacology*; D002460:Cell Line; D018031:Connexin 43 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006107:Granulosa Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000209:etiology / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000728:Androgens; D018031:Connexin 43; C500216:GJA1 protein, human; D015124:8-Bromo Cyclic Adenosine Monophosphate; D013739:Testosterone; C013915:boldenone