title: Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women.
abstract: BACKGROUND
  Irritable bowel syndrome (IBS) is commonly regarded as a functional disorder, and is hypothesized to be associated with anxiety and depression. This evidence mainly rests on population-based studies utilising self-report screening instruments for psychopathology. Other studies applying structured clinical interviews are generally based on small clinical samples, which are vulnerable to biases. The extant evidence base for an association between IBS and psychopathology is hence not conclusive. The aim of this study was therefore to re-examine the hypothesis using population-based data and psychiatric morbidity established with a structured clinical interview.
  
  
  METHODS
  Data were derived from a population-based epidemiological study (n = 1077). Anxiety and mood disorders were established using the Structured Clinical Interview for DSM-IV-TR (SCID-I/NP) and the General Health Questionnaire (GHQ-12). Current and lifetime IBS was self-reported. Hypertension and diabetes were employed as comparison groups as they are expected to be unrelated to mental health.
  
  
  RESULTS
  Current IBS (n = 69, 6.4%) was associated with an increased likelihood of current mood and/or anxiety disorders (OR = 2.62, 95%CI 1.49 - 4.60). Half the population reporting a lifetime IBS diagnosis also had a lifetime mood or anxiety disorder. Exploratory analyses demonstrated an increased prevalence of IBS across most common anxiety and mood disorders, the exception being bipolar disorder. The association with IBS and symptoms load (GHQ-12) followed a curved dose response pattern. In contrast, hypertension and diabetes were consistently unrelated to psychiatric morbidity.
  
  
  CONCLUSIONS
  IBS is significantly associated with anxiety and mood disorders. This study provides indicative evidence for IBS as a disorder with a psychosomatic aspect.
authors.affiliation: Norwegian Institute of Public Health, Division of Mental Heath, Oslo, Norway. arnstein.mykletun@uib.no
authors.forename: Arnstein
authors.initials: A
authors.lastname: Mykletun
authors.forename: Felice
authors.initials: F
authors.lastname: Jacka
authors.forename: Lana
authors.initials: L
authors.lastname: Williams
authors.forename: Julie
authors.initials: J
authors.lastname: Pasco
authors.forename: Margaret
authors.initials: M
authors.lastname: Henry
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Nicholson
authors.forename: Mark A
authors.initials: MA
authors.lastname: Kotowicz
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001008:Anxiety Disorders / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000523:psychology; D005260:Female; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000523:psychology; D007406:Interview, Psychological; D043183:Irritable Bowel Syndrome / Q000523:psychology*; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology*; D015995:Prevalence; D011602:Psychophysiologic Disorders / Q000523:psychology; D012650:Self Disclosure