Significance of the resection of ovarian metastasis from colorectal cancers.
BACKGROUND
The incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3-8% of CRC patients, and the prognosis for patients is very poor. We assessed the clinicopathological characteristics of CRC patients with ovarian metastasis and the significance of the resection of ovarian metastases.


METHODS
We retrospectively analyzed 22 CRC patients with ovarian metastases. Synchronous ovarian metastases occurred in 8 patients and metachronous ovarian metastases occurred in 14 patients. Peritoneal dissemination was observed in nine patients.


RESULTS
The mean follow-up period was 45.3 months. The overall survival at 3 years following diagnosis of ovarian metastases is estimated to be 51.1% and 43.8% at 5 years. The overall survival at 5 years in the group of patients without peritoneal disseminations was 77.9%, which is significantly longer than that of the patients with disseminations (0%) (P = 0.0009). An R0 resection of metastatic sites was achieved in 15 patients and was associated with a significant increase in survival time (P = 0.0002).


CONCLUSIONS
Our study shows that aggressive resection of ovarian metastases from CRCs is associated with better overall survival. Peritoneal dissemination is an adverse prognostic factor, but R0 resection significantly improves the overall survival of these patients.
Fujiwara
Ayako
A
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Noura
Shingo
S
Ohue
Masayuki
M
Shingai
Tatsushi
T
Yamada
Terumasa
T
Miyashiro
Isao
I
Ohigashi
Hiroaki
H
Yano
Masahiko
M
Ishikawa
Osamu
O
Kamiura
Shoji
S
Tomita
Yasuhiko
Y
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies