title: Measurement of arterial plasma oxygenation in dynamic oxygen-enhanced MRI.
abstract: Inhaled oxygen can be used as a contrast agent for magnetic resonance imaging, due to the T(1) shortening effect of the oxygen dissolved in blood and tissue water. In this study, blood T(1) was measured dynamically in 14 volunteers (seven smokers, seven never-smokers) as the inhaled gas was switched from medical air to 100% oxygen and back to medical air. These T(1) values were converted to changes in partial pressure of oxygen, which were found to be in agreement with literature values. There were differences in curve shape and curve height between the smoker and never-smoker groups, suggesting differences in lung function due to smoking-related damage. These curves could be used as an input function for modeling of oxygen uptake in tissues. The differences between groups highlight the importance of measuring such an input function for each individual rather than relying on an assumed measurement.
authors.affiliation: Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Lucy E
authors.initials: LE
authors.lastname: Kershaw
authors.forename: Josephine H
authors.initials: JH
authors.lastname: Naish
authors.forename: Deirdre M
authors.initials: DM
authors.lastname: McGrath
authors.forename: John C
authors.initials: JC
authors.lastname: Waterton
authors.forename: Geoffrey J M
authors.initials: GJ
authors.lastname: Parker
mesh_terms: D000388:Air; D001013:Aorta, Thoracic / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D012907:Smoking / Q000378:metabolism*; D013147:Spirometry; D018709:Statistics, Nonparametric
chemical_list: D010100:Oxygen