A congenital, erythematous eruption.
A 2-day-old male patient born full-term via uncomplicated vaginal delivery was seen for multiple erythematous, scaly papules that were present at birth. Physical examination showed a well-appearing male with erythematous papules with scale on his scalp, face, trunk, and bilateral upper and lower extremities. A 4 mm punch biopsy was performed on one of the representative papules on his abdomen and subsequent histopathological tests showed multiple Langerhans cells in the papillary dermis with positive CD1a and Langerin stains. There was no extracutaneous involvement. A diagnosis of congenital self-healing Langerhans cell histiocytosis was made.
Ballin
Jason S
JS
Naval Branch Health Clinic, Department of Aviation Medicine, Kingsville, Texas, USA. jason.ballin@med.navy.mil
Green
Brian P
BP
Gehris
Robin
R
Kress
Doug
D
Galambos
Csaba
C
D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1 / Q000032:analysis; D004890:Erythema / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D005145:Face; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D037181:Lectins, C-Type / Q000032:analysis; D035002:Lower Extremity; D008297:Male; D037241:Mannose-Binding Lectins / Q000032:analysis; D012535:Scalp; D034941:Upper Extremity
D015703:Antigens, CD; D018949:Antigens, CD1; C419393:CD1a antigen; C121916:CD207 protein, human; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins