Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin.
Anticonvulsant hypersensitivity syndrome is a severe, potentially life-threatening, reaction to the aromatic anticonvulsant medications. Reported here is a case of anticonvulsant hypersensitivity syndrome secondary to phenobarbital in a 2-year-old boy; he responded to drug withdrawal, corticosteroids, and intravenous immunoglobulin. The literature regarding treatment of this syndrome is reviewed.
Dredge
David C
DC
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. david.dredge@bhs.org
Parsons
Elizabeth C
EC
Carter
Lindsay P
LP
Staley
Kevin J
KJ
D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous; D010634:Phenobarbital