title: Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1.
abstract: We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.
authors.affiliation: Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Narukawa
authors.forename: Kanako
authors.initials: K
authors.lastname: Koizumi
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Kikue
authors.initials: K
authors.lastname: Kubota
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000494:pharmacology*; D015220:Calcium Channels / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D009419:Nerve Tissue Proteins / Q000819:agonists / Q000378:metabolism*; D009812:Odorants; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000819:agonists / Q000378:metabolism*
chemical_list: D001592:Benzyl Alcohols; D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels; C047948:1'-acetoxychavicol acetate