Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence.
Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.
Stallings
Christina L
CL
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Glickman
Michael S
MS
D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity / Q000502:physiology*; D013312:Stress, Physiological