title: Motivation for health information seeking and processing about clinical trial enrollment.
abstract: Low patient accrual in clinical trials poses serious concerns for the advancement of medical science in the United States. Past research has identified health communication as a crucial step in overcoming barriers to enrollment. However, few communication scholars have studied this problem from a sociopsychological perspective to understand what motivates people to look for or pay attention to information about clinical trial enrollment. This study applies the model of Risk Information Seeking and Processing (RISP) to this context of health decision making. By recognizing the uncertainties embedded in clinical trials, we view clinical trial enrollment as a case study of risk. With data from a random-digit-dial telephone survey of 500 adults living in the United States, we used structural equation modeling to test the central part of the RISP model. In particular, we examined the role of optimistic feelings, as a type of positive affect, in motivating information seeking and processing. Our results indicated that rather than exerting an indirect influence on information seeking through motivating a psychological need for more information, optimistic feelings have more direct relationships with information seeking and processing. Similarly, informational subjective norms also exhibit a more direct relationship with information seeking and processing. These results suggest merit in applying the RISP model to study health decision making related to clinical trial enrollment. Our findings also render practical implications on how to improve communication about clinical trial enrollment.
authors.affiliation: Department of Communication, University at Buffalo, State University of New York, College of Arts & Sciences, Buffalo, NY 14260, USA. zyang5@buffalo.edu
authors.forename: Z Janet
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Katherine
authors.initials: K
authors.lastname: McComas
authors.forename: Geri
authors.initials: G
authors.lastname: Gay
authors.forename: John P
authors.initials: JP
authors.lastname: Leonard
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dannenberg
authors.forename: Hildy
authors.initials: H
authors.lastname: Dillon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003625:Data Collection; D005260:Female; D006801:Humans; D057226:Information Seeking Behavior; D008297:Male; D008875:Middle Aged; D009042:Motivation; D010358:Patient Participation / Q000523:psychology*; D014481:United States; D055815:Young Adult