Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules.
Regioselective facile one-pot synthesis of 16 different sugar-based quinoline, naphthyridine, and xanthone derivatives is reported. The compounds are characterized by NMR spectroscopy and elemental analysis. The beta-Anomeric form of the sugar moiety was identified from (1)H NMR studies. Antimicrobial studies of these sugar-heterocyclic derivatives, 3a, 3b, 3f, 5c, 7a, 7b, and 7c show excellent activity against different microbes.
Nagarajan
Subbiah
S
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
Arjun
Pandian
P
Raaman
Nanjian
N
Das
Thangamuthu Mohan
TM
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011804:Quinolines / Q000138:chemical synthesis*; D044004:Xanthones / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D006027:Glycosides; D007783:Lactones; D009287:Naphthyridines; D011804:Quinolines; D044004:Xanthones