title: [Children's Langerhans cell histiocytosis, diagnostic problems].
abstract: Langerhans cell histiocytosis is a group of idiopathic disorders characterized by the proliferation of cells of the mononuclear phagocyte system and the dendritic cell system. From the clinical point of view there are 3 forms of histiocytosis encountered in child pathology: acute, disseminated called Abt-Letterer-Siwe (it usually affects children under 2 years of age), eosinophilic granuloma and the intermediate clinical form called Hand-Schuller-Christian disease. We present the case of a premature born child that had, even from the day she was born, a rash disseminated on the entire surface of the body associated with enlarged lymph nodes, hepatosplenomegaly and thrombocytopenia. The diagnosis of Langerhans cell Histiocytosis is difficult to establish and this case is an example that confirms it. Therefore, we present the difficulties in diagnosing this case and its particular evolution.
authors.affiliation: Universitatea de Medică şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a IV(-a) Pediatrie.
authors.forename: Anca
authors.initials: A
authors.lastname: Ivanov
authors.forename: Doina
authors.initials: D
authors.lastname: Mihăilă
authors.forename: Ingrid
authors.initials: I
authors.lastname: Miron
authors.forename: P
authors.initials: P
authors.lastname: Plămădeală
authors.forename: I
authors.initials: I
authors.lastname: Tansanu
mesh_terms: D003937:Diagnosis, Differential; D005076:Exanthema / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008206:Lymphatic Diseases / Q000209:etiology; D012307:Risk Factors; D013163:Splenomegaly / Q000209:etiology