A new nuclease member of the FAN club.
To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.
Huang
Min
M
D'Andrea
Alan D
AD
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004706:Endodeoxyribonucleases; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D005199:Fanconi Anemia / Q000201:enzymology*; D052236:Fanconi Anemia Complementation Group D2 Protein / Q000378:metabolism; D006801:Humans; D064251:Multifunctional Enzymes; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D054875:Ubiquitination; D014981:Xenopus
D052236:Fanconi Anemia Complementation Group D2 Protein; D064251:Multifunctional Enzymes; D018809:Proliferating Cell Nuclear Antigen; D004706:Endodeoxyribonucleases; D005090:Exodeoxyribonucleases; C551063:FAN1 protein, human