Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process.
An excellent mesoporous silica nanoparticle (MSN) based drug deliver system (DDS) was reported for regulated anticancer drug release upon the irradiation of either one- or two-photon excitation. In this system, the coumarin grafted on MSN acted as both the "phototrigger" for the drug release and fluorescence group for cell luminescence imaging. External light manipulations such as changing irradiation wavelength, intensity, and time can regulate the release of the anticancer drug precisely. Biological studies in vitro suggest that the drug carrier can effectively deliver the anticancer drug into intracellular environs and, hence, promote the drug action to kill the cancer cells upon irradiation. We envision that the good biocompatibility, cellular uptake property, and efficient photoregulated drug release will be of great benefit to future controlled release in vivo biomedical applications.
Lin
Qiuning
Q
Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, China.
Huang
Qi
Q
Li
Chunyan
C
Bao
Chunyan
C
Liu
Zhenzhen
Z
Li
Fuyou
F
Zhu
Linyong
L
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D017785:Photons; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
D000970:Antineoplastic Agents; D003374:Coumarins; D012822:Silicon Dioxide; C030123:coumarin