Immune activation and neuropsychiatric symptoms in HIV infection.
This study examined the role of biological processes in the development of specific neuropsychiatric complications in HAART-naive adults with HIV/AIDS. Depressive symptoms were modestly associated with elevated IL-6 mRNA expression (r(s)=0.40, p<0.05) even after removing the influences of other subjective complaints (pr=0.39, p<0.05). Elevated serum neopterin was strongly associated with depressive symptoms in individuals taking antidepressants (r(s)=0.83, p<0.001), though the association was nullified in those not on antidepressants (r(s)=-0.25, p>0.05). Mean neopterin levels were higher in the depressed as compared with nondepressed group but only for those taking antidepressants (F=45.66, df=1, 11, p<0.001). Neuropsychological impairment was not associated with the biological markers. These findings suggest that systemic immune markers (like neopterin) may be useful in differentiating treatment-resistant individuals at greater risk of developing chronic depression.
Warriner
Erin M
EM
St. Michael's Hospital, Neurobehavioural Research Unit in HIV/AIDS, 30 Bond Street, Shuter Wing, Rm. 2-044, Toronto, ON, M5B 1W8.
Rourke
Sean B
SB
Rourke
Byron P
BP
Rubenstein
Sarah
S
Millikin
Colleen
C
Buchanan
Lori
L
Connelly
Phil
P
Hyrcza
Martin
M
Ostrowski
Mario
M
Der
Sandy
S
Gough
Kevin
K
D000328:Adult; D000704:Analysis of Variance; D003863:Depression / Q000150:complications* / Q000276:immunology / Q000523:psychology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000523:psychology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D019798:Neopterin / Q000097:blood / Q000276:immunology; D009483:Neuropsychological Tests; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019798:Neopterin