title: Functionalization of aromatic amino acids via direct C-H activation: generation of versatile building blocks for accessing novel peptide space.
abstract: Functionalized alpha-amino acid building blocks have been prepared in good yield with high regiocontrol and preservation of stereochemistry via iridium-catalyzed borylation of suitably protected aromatic alpha-amino acid derivatives. The utility of these systems in peptide couplings and Suzuki reactions has been demonstrated.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Falco-Magnus
authors.initials: FM
authors.lastname: Meyer
authors.forename: Spiros
authors.initials: S
authors.lastname: Liras
authors.forename: Angel
authors.initials: A
authors.lastname: Guzman-Perez
authors.forename: Christian
authors.initials: C
authors.lastname: Perreault
authors.forename: Jianwei
authors.initials: J
authors.lastname: Bian
authors.forename: Keith
authors.initials: K
authors.lastname: James
mesh_terms: D024322:Amino Acids, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007495:Iridium / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D024322:Amino Acids, Aromatic; D010455:Peptides; D007495:Iridium