New method for comparing DNA primary sequences based on a discrimination measure.
We introduce a new approach to compare DNA primary sequences. The core of our method is a new measure of pairwise distances among sequences. Using the primitive discrimination substrings of sequence S and Q, a discrimination measure DM(S, Q) is defined for the similarity analysis of them. The proposed method does not require multiple alignments and is fully automatic. To illustrate its utility, we construct phylogenetic trees on two independent data sets. The results indicate that the method is efficient and powerful.
Feng
Jie
J
School of Mathematical Sciences, Capital Normal University, Beijing 100048, China. fengjie0536@163.com
Hu
Yong
Y
Wan
Ping
P
Zhang
Aibing
A
Zhao
Weizhong
W
D000818:Animals; D001483:Base Sequence / Q000235:genetics*; D017934:Coronavirus / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D010802:Phylogeny; D016415:Sequence Alignment / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D055544:beta-Globins / Q000235:genetics
D055544:beta-Globins