title: Surgical treatment in Paget's disease of the breast.
abstract: BACKGROUND
  The aim of this study was to evaluate the outcomes of surgical treatment of Paget's disease of the breast, with special emphasis on magnetic resonance imaging (MRI) and sentinel node biopsy (SNB).
  
  
  METHODS
  The study included 58 consecutive patients with Paget's disease treated from 1995 to 2006.
  
  
  RESULTS
  Twenty-five patients had ductal carcinoma in situ, and 31 had invasive carcinoma. MRI was performed in 14 patients, with positive findings in 7 patients, 5 of whom had negative findings on conventional imaging. The overall mastectomy rate was 76%. Eighteen patients underwent SNB, and 26 patients underwent full or partial axillary clearance. Fourteen patients had no axillary surgery. One patient had local recurrence after breast conservation, and another had axillary recurrence after negative results on SNB. Six patients had distant metastases. Four patients died of breast cancer.
  
  
  CONCLUSIONS
  Paget's disease is frequently associated with peripheral or multicentric cancer. MRI may be helpful when considering breast conservation or omitting axillary nodal staging.
authors.affiliation: Helsinki University Central Hospital, Finland. elina.siponen@elisanet.fi
authors.forename: Elina
authors.initials: E
authors.lastname: Siponen
authors.forename: Katja
authors.initials: K
authors.lastname: Hukkinen
authors.forename: Päivi
authors.initials: P
authors.lastname: Heikkilä
authors.forename: Heikki
authors.initials: H
authors.lastname: Joensuu
authors.forename: Marjut
authors.initials: M
authors.lastname: Leidenius
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001940:Breast / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000175:diagnosis / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008875:Middle Aged; D010144:Paget's Disease, Mammary / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D016896:Treatment Outcome