Further insights into the ubiquitin pathway: understanding the scarlet letter code.
Understanding the machinery that decides proteins' fate by tagging them with ubiquitin is an important goal of structural biology. Benirschke et al. (2010) have solved the structure of human E4B (or UFD2a), a U-box-containing protein that functions both as an E3 Ub ligase and as an E4 polyUb chain elongation factor.
Pastore
Annalisa
A
MRC National Institute for Medical Research, The Ridgeway, London NW71AA, UK. apastor@nimr.mrc.ac.uk