title: Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age.
abstract: A macrolide-resistant Mycoplasma pneumoniae strain was isolated from two patients with community-acquired pneumonia. The pneumonia severity score of both patients was mild, and rapid clinical improvement was seen after administration of fluoroquinolone. Clinical features of macrolide-resistant M. pneumoniae pneumonia were identical to those of macrolide-sensitive M. pneumoniae pneumonia. An A-to-G transition at position 2063 and 2064, respectively, in domain V of the 23S rRNA gene was identified. The minimum inhibitory concentration of erythromycin of these isolates was greatly elevated. In Japan, macrolide-resistant M. pneumoniae infections are common in pediatric patients but not in adults. However, physicians should pay attention to macrolide-resistant M. pneumoniae not only in children but also in adults.
authors.affiliation: Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan. nao@med.kawasaki-m.ac.jp
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyashita
authors.forename: Takaya
authors.initials: T
authors.lastname: Maruyama
authors.forename: Tetsu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Osamu
authors.initials: O
authors.lastname: Taguchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ouchi
authors.forename: Mikio
authors.initials: M
authors.lastname: Oka
mesh_terms: D000293:Adolescent; D000328:Adult; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004269:DNA, Bacterial / Q000032:analysis; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008826:Microbial Sensitivity Tests; D009177:Mycoplasma pneumoniae / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012338:RNA, Ribosomal, 23S / Q000032:analysis; D011859:Radiography
chemical_list: D004269:DNA, Bacterial; D024841:Fluoroquinolones; D012338:RNA, Ribosomal, 23S; D004917:Erythromycin