Effect of traditional and integrative regimens on quality of life and early renal impairment in elderly patients with isolated systolic hypertension.
OBJECTIVE
To observe the effect of Chinese medical regimen and integrative medical regimen on quality of life and early renal impairment in elderly patients with isolated systolic hypertension (EISH).


METHODS
A multi-center, randomized, double-blinded controlled trail was adopted. A total of 270 cases of EISH were randomly divided into 3 groups: Chinese medicine group (CM), combination group and Western medicine group (WM). The course of treatment was 4 weeks. The clinical blood pressure, integral of quality of life (SF-36 scale), immunoglubin G (IgG), microalbumin (mALB), beta(2)-microglobulin (beta(2)-MG), transferrin (TRF) and N-acetyl-beta'-D-glucosa-minidase (NAG) in urine were determined before and after the treatment.


RESULTS
After treatment, systolic blood pressure depressed significantly in each group (P<0.05), and the combination group was superior to CM or WM group in depressing SBP (P<0.05); in each group, integral of quality of life improved in different degree, and combination group was superior to WM group in all 8 dimensions (P<0.05). The level of mALB and beta(2)-MG in urine decreased in all groups (P<0.05), and the combination group was superior to CM group or WM group in decreasing mALB (P<0.05).


CONCLUSIONS
Chinese medical regimen has affirmative effect in treating EISH patients, and could lower the systolic blood pressure, improve quality of life and early renal impairment of the patients, and integrative medical regimen has superiority on account of cooperation, and deserves further study.
Li
Hao
H
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. xyhplihao@vip.sohu.com
Liu
Long-tao
LT
Zhao
Wen-ming
WM
Liu
Jian-gang
JG
Yao
Ming-jiang
MJ
Han
Yong-xiang
YX
Shen
Yan-peng
YP
Liu
Xing-dong
XD
Liu
Li
L
Wang
Xue-mei
XM
Cai
Lin-lin
LL
Guan
Jie
J
D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D055048:Integrative Medicine; D007668:Kidney / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D011788:Quality of Life; D013599:Systole / Q000187:drug effects / Q000502:physiology*
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal