title: Programmed assembly of peptide-functionalized gold nanoparticles on DNA templates.
abstract: We present a novel nanoparticle building block system based on the interactions between short synthetic oligonucleotides and peptides. Gold nanoparticles coated with DNA-binding peptides can be attached to self-organized oligonucleotide templates to formulate well-ordered structures of nanoparticles. By regulating the amount of DNA-binding peptide attached to the nanoparticle surface and using specifically designed oligonucleotides, the nanoparticle assembly can be controlled to form dimers, trimers, and adjustable-length nanoparticle chains as well as more complex structures.
authors.affiliation: School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ, UK.
authors.forename: Danielle
authors.initials: D
authors.lastname: Coomber
authors.forename: Dorota
authors.initials: D
authors.lastname: Bartczak
authors.forename: Simon R
authors.initials: SR
authors.lastname: Gerrard
authors.forename: Sarah
authors.initials: S
authors.lastname: Tyas
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Kanaras
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D009841:Oligonucleotides; D010455:Peptides; D006046:Gold; D004247:DNA