[Pemphigoid gestationis].
Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis associated with pregnancy. Its previous designation, herpes gestationis, is obsolete. PG is characterized by a subepidermic separation induced by the presence of peripheral blood autoantibodies against two hemidesmosomal antigens: BPAG1 and BPAG2. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence tests. The most discriminant examination for other pruritic dermatoses of pregnancy is the enzyme-linked immunosorbent assay (Elisa) NC16A BP 180. First-line treatment is local corticosteroid therapy; if local treatment fails, general corticosteroid therapy should be administered. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Management in a specialized setting is therefore necessary. Recurrence is possible during subsequent pregnancies.
Estève
Eric
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CHR Orléans, hôpital Porte-Madeleine, service de dermatologie, rue Porte-Madeleine, 45032 Orléans cedex 1, France. eric.esteve@chr-orleans.fr
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001324:Autoantigens / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D003598:Cytoskeletal Proteins / Q000276:immunology; D003937:Diagnosis, Differential; D000071821:Dystonin; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005455:Fluorescent Antibody Technique; D006652:Histological Techniques; D006801:Humans; D009419:Nerve Tissue Proteins / Q000276:immunology; D024041:Non-Fibrillar Collagens / Q000276:immunology; D006559:Pemphigoid Gestationis / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology; D011379:Prognosis; D012008:Recurrence; D000097805:Collagen Type XVII
D000893:Anti-Inflammatory Agents; D001324:Autoantigens; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human