title: Small solid pseudopapillary tumor of the pancreas in a 32-year-old man: report of a case.
abstract: A solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm that mainly occurs in young women. We herein report the case of a small SPT arising from the head of the pancreas in an asymptomatic 32-year-old man, plus a literature review of this tumor. A 32-year-old man was admitted to our department at Kumamoto University Hospital for the evaluation of a pancreatic mass. The tumor had central necrosis, which was poorly perfused on contrast-enhanced computed tomography (CT) and which had a high intensity on T2-weighted magnetic resonance imaging (MRI). Histology revealed the lesion to be a solid pseudopapillary tumor of the pancreas, with the characteristic pseudopapilla formation and central degeneration. However, no capsule formation was observed. The tumor was positive for CD56, CD10, alpha1-antitrypsin, alpha1-antichymotrypsin, beta-catenin, and progesterone receptor. However, the tumor was negative for pancreatic hormones, chromogranin-A, carcinoembryonic antigen, and carbohydrate antigen 19-9. We diagnosed the patient to have an SPT based on these histological findings. Small-sized solid pseudopapillary tumors of the pancreas are being increasingly recognized because of the recent advances in CT and MRI. We should also consider SPT even if it occurs in a male when the tumor contains necrosis-suspected areas which are poorly perfused on contrast-enhanced CT with a high intensity on T2-weighted MRI.
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Mima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hirota
authors.forename: Shinya
authors.initials: S
authors.lastname: Abe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iwatsuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Shu
authors.initials: S
authors.lastname: Tsuruzoe
authors.forename: Akira
authors.initials: A
authors.lastname: Chikamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takamori
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Kanemitsu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tagami
authors.forename: Yumi
authors.initials: Y
authors.lastname: Honda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Iyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Baba
mesh_terms: D000328:Adult; D019002:CD56 Antigen; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008297:Male; D015260:Neprilysin; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011379:Prognosis; D011980:Receptors, Progesterone; D014057:Tomography, X-Ray Computed; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D051176:beta Catenin
chemical_list: D019002:CD56 Antigen; D011980:Receptors, Progesterone; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D051176:beta Catenin; D015260:Neprilysin