Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
Marakalala
Mohlopheni J
MJ
Institute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town, South Africa.
Kerrigan
Ann M
AM
Brown
Gordon D
GD
D000818:Animals; D005658:Fungi / Q000276:immunology* / Q000502:physiology; D006801:Humans; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000235:genetics* / Q000276:immunology*; D009181:Mycoses / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic; D000099181:Dectin-1
D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D000099181:Dectin-1