title: Palhinine A, a novel alkaloid from Palhinhaea cernua.
abstract: Palhinine A, a novel C(16)N-type Lycopodium alkaloid with a unique 5/6/6/9 tetracyclic ring system, was isolated from the whole plant of Palhinhaea cernua L. (Lycopodiaceae). Its structure was elucidated by spectroscopic methods, and the absolute configuration was determined by single-crystal X-ray diffraction analysis using the Flack parameter. Palhinine A is reported as the first example of Lycopodium alkaloids of which C-16 is fused to a new ring through a C-16-C-4 lingkage.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Fu-Wei
authors.initials: FW
authors.lastname: Zhao
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Sun
authors.forename: Fu-Mei
authors.initials: FM
authors.lastname: Yang
authors.forename: Guang-Wan
authors.initials: GW
authors.lastname: Hu
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Luo
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D032502:Lycopodium / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C553649:palhinine A; D000110:Acetylcholinesterase