Genomic instability in patients with Barrett's esophagus.
Our study aimed to determine, by counting sister chromatid exchange (SCE) and micronucleus (MN) frequencies, whether genetic impairment and DNA damage have an effect on the pathogenesis of Barrett's esophagus (BE). This study was conducted between June 2007 and November 2008 in the Erzurum Training and Research Hospital. We analyzed SCE and MN frequencies in 30 patients with BE, and in 30 control cases. SCE was significantly increased in BE patients compared with controls (6.89 +/- 1.04 vs. 5.01+/- 0.88, P < 0.001). Similarly, MN was significantly increased in BE patients compared with controls (3.48 +/- 1.08 vs. 1.83 +/- 0.64, P < 0.001). Our data indicate that the increased SCE and MN rates in lymphocytes of patients with BE may reflect genomic instability or deficiency of DNA repair capacity.
Karaman
Ali
A
Department of Medical Genetics, Erzurum Training and Research Hospital, Turkey. alikaramandr@hotmail.com
Binici
Doğan Nasir
DN
Kabalar
Mehmet Eşref
ME
Koca
Timur
T
Dursun
Hakan
H
D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D042822:Genomic Instability; D006801:Humans; D007963:Leukocytes, Mononuclear; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D008875:Middle Aged; D012854:Sister Chromatid Exchange; D018709:Statistics, Nonparametric