title: PEGylated iminodiacetic acid zinc complex stabilizes cationic RNA-bearing nanoparticles.
abstract: Self-assembling nanoparticles comprising cationic polymers are of interest for the delivery of oligonucleotide-based therapeutics. Unfortunately, exposure of the nanoparticle cationic surface to plasma and plasma proteins compromises particle stability and circulating half-life. Herein, we report that improved nanoparticle stability can be achieved through temporary grafting of PEG to the nanoparticle surface. Grafting is induced through zinc complexation between PEG-IDA and the exposed polyhistidylated polylysine (H-K) cationic polymer of pre-formed nanoparticles.
authors.affiliation: Intradigm Corporation, 3350 West Bayshore Road, Suite 100, Palo Alto, CA 94303, USA. del345@gmail.com
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Levy
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Ding
authors.forename: Chiwei
authors.initials: C
authors.lastname: Hu
authors.forename: Samuel
authors.initials: S
authors.lastname: Zalipsky
mesh_terms: D007098:Imino Acids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage*; D015032:Zinc / Q000737:chemistry*
chemical_list: D007098:Imino Acids; D034741:RNA, Small Interfering; C094451:poly(ethylene glycol-iminodiacetic acid); D011107:Polylysine; D011092:Polyethylene Glycols; D015032:Zinc