title: The impact of the waveguide aperture size of the 3D 70 MHz AMC-8 locoregional hyperthermia system on tumour coverage.
abstract: The 70 MHz AMC-4 system, with one ring of four waveguides, provides 2D power steering. The newly developed AMC-8 system enables 3D steering, using two rings of four 70 MHz waveguides. The current waveguide aperture size is 20.2 x 34.3 cm(2). Waveguides and water boluses cover a large area of the body, which is not ideal for short patients. The aim of this study is investigating the impact of smaller waveguides on tumour coverage, using treatment planning. Finite-difference time-domain simulations were performed at 2.5 x 2.5 x 5 mm(3) resolution. Virtual AMC-8 systems with waveguide aperture sizes of 20.5 x 34.25, 17.5 x 34.25, 14.5 x 34.25, 11.5 x 34.25, 8.5 x 34.25 cm(2) and the AMC-4 system were modelled. Simulations were performed for elliptical (36 x 24 x 100 cm(3)) tissue-equivalent phantoms and for five cervical cancer patients. For the phantoms S(ratio) (SAR(max_border)/SAR(target)) was evaluated for standard and optimized settings. For the patients, temperature distributions were evaluated after optimization of tumour temperature, while limiting normal tissue temperatures to 45 degrees C. Phantom simulations showed a favourable S(ratio) for all two-ring systems, compared to the AMC-4 system, for optimized phase-amplitude settings. Patient simulations demonstrated that the improvement in T(90) for the operational AMC-8 system was approximately 0.5 degrees C. This improvement was independent of the aperture size. The average number of imminent hot spots and their total volume was almost comparable for 8.5 and 20.5 cm wide apertures, but the locations were different. Two-ring waveguide systems with eight antennas and aperture sizes in the range from 20.5 x 34.25 cm(2) to 8.5 x 34.25 cm(2) showed a stable gain in tumour temperature compared to a single-ring four-antenna system with 20.5 x 34.25 cm(2) wide apertures.
authors.affiliation: Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. H.P.Kok@amc.uva.nl
authors.forename: H P
authors.initials: HP
authors.lastname: Kok
authors.forename: M
authors.initials: M
authors.lastname: de Greef
authors.forename: J
authors.initials: J
authors.lastname: Wiersma
authors.forename: A
authors.initials: A
authors.lastname: Bel
authors.forename: J
authors.initials: J
authors.lastname: Crezee
mesh_terms: D003198:Computer Simulation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000379:methods; D021621:Imaging, Three-Dimensional; D019047:Phantoms, Imaging; D020266:Radiotherapy, Conformal / Q000295:instrumentation* / Q000379:methods; D013696:Temperature; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*