title: Analysis of omnoponum by surface-ionization mass spectrometry and liquid chromatography tandem mass spectrometry methods.
abstract: This paper provides the development of analytical capabilities of surface-ionization mass spectrometry (SI/MS) and high performance liquid chromatography with tandem mass spectrometry (HPLC/MS/MS) for narcotic analgesic omnoponum, which perfectly exemplifies a mixture of opium alkaloids. It has been revealed that the investigated opiates solution, omnoponum, is ionized by the surface ionization (SI) method with high sensitivity. In the SI mass spectrum, M+, (M-H)+, (M-H-2nH)+, (M-R)+ and (M-R-2nH)+ ion lines, where M is a molecule, H is the hydrogen atom and R is a radical, were observed. These ion lines consist of combined omnoponum mixture SI mass spectra, i.e. morphine, codeine, thebaine, papaverine, and narcotine. Moreover, while the study of omnoponum by HPLC/MS/MS methods has attested that the mixture really consists of 5 components, it has been demonstrated that the SI/MS method can be utilized for the analysis of this mixture without the necessity of its chromatographic separation.
authors.affiliation: Arifov Institute of Electronics, Dormon Yoli Street 33, Akademgorodok, Tashkent, Uzbekistan. usmanov@aie.uz
authors.forename: Dilshadbek
authors.initials: D
authors.lastname: Usmanov
authors.forename: Usman
authors.initials: U
authors.lastname: Khasanov
authors.forename: Aleksey
authors.initials: A
authors.lastname: Pantsirev
authors.forename: Jan
authors.initials: J
authors.lastname: Van Bocxlaer
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003061:Codeine / Q000032:analysis; D009020:Morphine / Q000032:analysis; D009892:Opium / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D009020:Morphine; D009892:Opium; D003061:Codeine