title: Loop-anchor purse-string closure of gastrotomy in NOTES(R) procedures: survival studies in a porcine model.
abstract: BACKGROUND
  Transgastric NOTES(®) procedures remain without a simple method to close the gastrotomy. In four survival swine studies, we have tested a novel gastric closure device: the loop-anchor purse-string (LAPS) closure system.
  
  
  METHODS
  In four anesthetized pigs, an endoscopic gastrotomy was performed. Four loop anchors were arrayed in a 2-cm square pattern around the gastrotomy. The endoscope was passed into the abdominal cavity, and the gastrotomy was cinched closed.
  
  
  RESULTS
  Procedure times ranged from 50-180 minutes. Three pigs survived 14 days. One animal was sacrificed early due to signs of sepsis. Another animal developed fevers and was treated with antibiotics. At necropsy, there were no abscesses, including in the septic animal. Histologic examination revealed evidence of healing in all animals.
  
  
  CONCLUSIONS
  The LAPS system holds promise with early success in an animal model. Future human studies are needed to determine viability as a human visceral closure device.
authors.affiliation: Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA. john.romanelli@bhs.org
authors.forename: John R
authors.initials: JR
authors.lastname: Romanelli
authors.forename: David J
authors.initials: DJ
authors.lastname: Desilets
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Chapman
authors.forename: Vihar C
authors.initials: VC
authors.lastname: Surti
authors.forename: Carolanne
authors.initials: C
authors.lastname: Lovewell
authors.forename: David B
authors.initials: DB
authors.lastname: Earle
mesh_terms: D000497:Alloys; D000818:Animals; D005260:Female; D005774:Gastrostomy; D023421:Models, Animal; D057605:Natural Orifice Endoscopic Surgery; D013536:Suture Techniques / Q000295:instrumentation*; D013537:Sutures; D013552:Swine; D014781:Viscera / Q000601:surgery
chemical_list: D000497:Alloys; C013616:nitinol