title: Indoor use of plastic sheeting impregnated with carbamate combined with long-lasting insecticidal mosquito nets for the control of pyrethroid-resistant malaria vectors.
abstract: The combined efficacy of a long-lasting insecticidal net (LLIN) and a carbamate-treated plastic sheeting (CTPS) or indoor residual spraying (IRS) for control of insecticide-resistant mosquitoes was evaluated in experimental huts in Burkina Faso. Anopheles gambiae from the area is resistant to pyrethroids and to a lesser extent, carbamates. Relatively low mortality rates were observed with the LLIN (44%), IRS (42%), and CTPS (52%), whereas both combinations killed significantly more mosquitoes (~70% for LLIN + CTPS and LLIN + IRS). Blood feeding by An. gambiae was uninhibited by IRS and CTPS compared with LLIN (43%), LLIN + CTPS (58%), and LLIN + IRS (56%). No evidence for selection of the kdr and ace-1(R) alleles was observed with the combinations, whereas a survival advantage of mosquitoes bearing the ace-1(R) mutation was observed with IRS and CTPS. The results suggest that the combination of the two interventions constitutes a potential tool for vector-resistance management.
authors.affiliation: Centre de Recherche Entomologique de Cotonou, Unité de Recherche 016 Institut de Recherche pour le Développement, Cotonou, Bénin. armeldj@yahoo.fr
authors.forename: Armel
authors.initials: A
authors.lastname: Djènontin
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chandre
authors.forename: K Roch
authors.initials: KR
authors.lastname: Dabiré
authors.forename: Joseph
authors.initials: J
authors.lastname: Chabi
authors.forename: Raphael
authors.initials: R
authors.lastname: N'guessan
authors.forename: Thierry
authors.initials: T
authors.lastname: Baldet
authors.forename: Martin
authors.initials: M
authors.lastname: Akogbéto
authors.forename: Vincent
authors.initials: V
authors.lastname: Corbel
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007303:Insect Vectors / Q000187:drug effects* / Q000235:genetics; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009032:Mosquito Control; D057147:Mosquito Nets; D009154:Mutation; D048448:Phenylcarbamates / Q000494:pharmacology*; D010969:Plastics; D011722:Pyrethrins / Q000494:pharmacology
chemical_list: D007306:Insecticides; D048448:Phenylcarbamates; D010969:Plastics; D011722:Pyrethrins; C007725:bendiocarb