Click-xylosides mitigate glioma cell invasion in vitro.
Tumor related invasion allows cancers to spread beyond tissue boundaries and significantly affects patient prognosis. In this study we show that several click-xylosides markedly inhibit the invasive capability of a highly invasive glioma cell line in vitro. These novel xylosides are promising chemical biology tools to probe the role of the proteoglycan glycome in regulating tumor biology.
Raman
Karthik
K
Department of Bioengineering, University of Utah, 30 S 2000 E, Skaggs Hall Room 307, Salt Lake City, Utah 84112, USA.
Kuberan
Balagurunathan
B
D001932:Brain Neoplasms / Q000473:pathology*; D005910:Glioma / Q000473:pathology*; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000517:prevention & control*
D006027:Glycosides; C010807:xylosides