title: [Effects of deer tendons collagen on osteoporosis rats induced by retinoic acid].
abstract: OBJECTIVE
  To study the effects of deer tendons collagen on osteoporosis rats induced by retinoic acid.
  
  
  METHODS
  Male Wistar rats were randomly divided into normal control group, model control group, deer tendons collagen high, medium and low-dose groups, osteoporosis rats of retinoic acid-induced were set up. Changes of body weight, bone weight, bone mineral density, bone histomorphometry, plasma phosphorus, calcium, alkaline phosphatase (ALP), bone mechanics were measured before and after treatment of deer tendons collagen.
  
  
  RESULTS
  Compared with model control group,after treated by deer tendons collagen, body weight, bone mineral density, bone weight was increased in varying degrees, bone histomorphometry parameters were significantly different, the ALP in plasma was significantly reduced, contents of Ca, P were increased, all indicators of bone mechanics were significantly higher.
  
  
  CONCLUSIONS
  Deer tendons collagen can prevent and treat retinoic acid-induced osteoporosis of rats.
authors.affiliation: Changchun University of Traditional Chinese Medicine, Changchun 130117, China.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yin-Qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Xiao-Di
authors.initials: XD
authors.lastname: Sun
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Bai
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Zhao
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D003094:Collagen / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003670:Deer; D004195:Disease Models, Animal; D005269:Femur / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use*; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013710:Tendons; D014212:Tretinoin
chemical_list: D008419:Materia Medica; D014212:Tretinoin; D003094:Collagen; D000469:Alkaline Phosphatase; D002118:Calcium