Oppositinines A and B: new vasorelaxant beta-carboline alkaloids from Neisosperma oppositifolia.
A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.
Ahmad
Kartini
K
Department of Chemistry, Faculty of Science and Technology, University Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
Thomas
Noel F
NF
Hadi
A Hamid A
AH
Mukhtar
Mat Ropi
MR
Mohamad
Khalit
K
Nafiah
Mohd Azlan
MA
Takeya
Koichi
K
Morita
Hiroshi
H
Litaudon
Marc
M
Arai
Hiroko
H
Awang
Khalijah
K
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D029062:Apocynaceae / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D002243:Carbolines; D010936:Plant Extracts; D014665:Vasodilator Agents; C553891:oppositinine A; C553892:oppositinine B; D009569:Nitric Oxide