title: Highly efficient and expedient synthesis of 5-hydroxy-1H-pyrrol-2-(5H)-ones from FeCl3-catalyzed tandem intramolecular enaminic addition of tertiary enamides to ketones and 1,3-hydroxy rearrangement.
abstract: Catalyzed by FeCl(3) under very mild conditions, tertiary enamides underwent a highly efficient intramolecular enaminic addition reaction to the ketonic carbonyls followed by 1,3-hydroxy rearrangement to produce 5-hydroxy-1H-pyrrol-2(5H)-ones in excellent yields.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Yang
authors.forename: Chuan-Hu
authors.initials: CH
authors.lastname: Lei
authors.forename: De-Xian
authors.initials: DX
authors.lastname: Wang
authors.forename: Zhi-Tang
authors.initials: ZT
authors.lastname: Huang
authors.forename: Mei-Xiang
authors.initials: MX
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D005290:Ferric Compounds / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D002712:Chlorides; D005290:Ferric Compounds; D007659:Ketones; D011758:Pyrroles; C024555:ferric chloride