Treatment of inflammatory bowel disease with Chinese drugs administered by both oral intake and retention enema.
OBJECTIVE
To study the clinical effect of Chinese drugs administered by both oral intake and retention enema on inflammatory bowel diseases (IBD).


METHODS
Adopting a randomized controlled design, 78 patients were assigned to three groups: 26 patients in group A treated with Chinese drugs given by both oral intake and retention enema, 27 in group B with Chinese drugs given by retention enema only, and 25 in group C with given Western medicine. The changes before and after a 30-day treatment of the patients' symptoms (including diarrhea, abdominal pain, mucous or pus-bloody stool), colonoscopic examination scores and histopathology of the colonic membrane were observed.


RESULTS
Group A showed the best outcomes in all the aspects of clinical comprehensive effectiveness. Improvements in the main symptoms, colonoscopic scores and histopathology of the colonic membrane were significantly different from those in groups B and C, respectively (P<0.05). Meanwhile comparisons between groups B and C showed insignificant differences (P>0.05); group B was better in ameliorating tenesmus (P<0.05).


CONCLUSIONS
Through the use of Chinese drugs administered by both oral intake and retention enema to treat IBD, which combined external-internal therapies for both overall regulation and local management, it was confirmed that the Chinese medicine could embody the therapeutic principle of attending to both disease-diagnosis and syndrome-differentiation.
Ling
Xiao-hua
XH
Department of Digestive Diseases, The 4th Hospital Affiliated to Harbin Medical University, Harbin, China. lingxh107@163.com
Yu
Xin
X
Kong
De-jun
DJ
Hu
Cheng-yi
CY
Hong
Yu
Y
Yang
Xiao-ming
XM
D000284:Administration, Oral; D000328:Adult; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003113:Colonoscopy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D004733:Enema; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
D004365:Drugs, Chinese Herbal