A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers.
BACKGROUND
Acrylamide is a probable human carcinogen formed during cooking of many common foods. Epidemiologic studies on acrylamide and breast cancer risk have been null; however, positive associations with ovarian and endometrial cancers have been reported. We studied acrylamide intake and risk for breast, endometrial, and ovarian cancers in a prospective cohort study.


METHODS
We assessed acrylamide intake among 88,672 women in the Nurses' Health Study using food frequency questionnaires administered every 4 years. Between 1980 and 2006, we identified 6,301 cases of invasive breast cancer, 484 cases of invasive endometrial adenocarcinoma, and 416 cases of epithelial ovarian cancer. We used Cox proportional hazards models to study the association between acrylamide and cancer risk.


RESULTS
We found no association between acrylamide intake and breast cancer overall or according to estrogen and progesterone receptor status. We found an increased risk for endometrial cancer among high acrylamide consumers (adjusted relative risk for highest versus lowest quintile = 1.41; 95% CI, 1.01-1.97; P for trend = 0.03). We observed a nonsignificant suggestion of increased risk for ovarian cancer overall (relative risk, 1.25; 95% CI, 0.88-1.77; P trend = 0.12), with a significantly increased risk for serous tumors (relative risk, 1.58; 95% CI, 0.99-2.52; P trend = 0.04). Associations did not differ by smoking status.


CONCLUSIONS
We observed no association between acrylamide and breast cancer. Risk for endometrial cancer and possibly ovarian cancer was greater among high acrylamide consumers.


CONCLUSIONS
This is the second prospective study to report positive associations with endometrial and ovarian cancers. These associations should be further evaluated to inform public health policy.
Wilson
Kathryn M
KM
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. kwilson@hsph.harvard.edu
Mucci
Lorelei A
LA
Rosner
Bernard A
BA
Willett
Walter C
WC
D020106:Acrylamide / Q000008:administration & dosage* / Q000506:poisoning; D000328:Adult; D001943:Breast Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D015331:Cohort Studies; D004034:Diet Surveys; D016889:Endometrial Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D020106:Acrylamide