Evaluation of radicals scavenging, immunity-modulatory and antitumor activities of longan polysaccharides with ultrasonic extraction on in S180 tumor mice models.
Longan (Dimocarpus longan Lour.) is used as a traditional edible and medicinal material in China. In this paper, the effects of polysaccharides from longan pulp with ultrasonic extraction (UELP) on the radicals scavenging, immunity-modulatory and antitumor activities in S180 tumor mice models were investigated. UELP showed excellent scavenging activity on the hydroxyl radicals and a,a-diphenyl-1-picrylhydrazyl (DPPH) radicals, and obtained the almost complete scavenging effect. UELP with medium-dose (200mg/kg) and low-dose (100mg/kg) had potent immune-modulatory effects in S180 tumor mice model and exhibited significant effect on delayed-type hypersensitivity (DTH) response, macrophage phagocytosis and ConA-stimulated splenocyte proliferation as compared with model control treatment (p<0.01). The results still showed that UELP had great antitumor effects, and maximum inhibition rate was obtained at medium-dose and low-dose (200 and 100mg/kg).
Zhong
Kui
K
Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China.
Wang
Qiang
Q
He
Yin
Y
He
Xuanhui
X
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005591:Chemical Fractionation / Q000379:methods*; D005260:Female; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D017665:Hydroxyl Radical / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007155:Immunologic Factors / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000276:immunology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D011134:Polysaccharides / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D029631:Sapindaceae / Q000737:chemistry*; D012509:Sarcoma / Q000473:pathology*; D013154:Spleen / Q000276:immunology; D014465:Ultrasonics
D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007155:Immunologic Factors; D010851:Picrates; D011134:Polysaccharides; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl