Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study.
BACKGROUND
Osteosarcomas (OS) of the jaws are uncommon lesions that represent less than 10% of all skeletal OS. It has a behavioral pattern which is less aggressive than their long bones counterparts. This study performed an immunohistochemical comparison between jaws and long bones OS.


METHODS
The study involved 15 jaws and 15 long bones OS tissue samples for the period from 1986 to 2005. Age, sex, histologic subtypes and grades were recognized. The samples were immunohistochemically stained with monoclonal antibodies to Ki-67, P53 and vascular endothelial growth factor (VEGF).


RESULTS
The mean age of the patients with jaw OS was a decade higher than that of long bones OS. A slight male predominance in jaw OS was found (1.14:1), which was more pronounced in long bones OS (2:1). The chondroblastic subtype was the predominant in jaws (66.66%), whereas (60%) of long bones OS were of osteoblastic subtype. The Ki-67 labeling index and the VEGF expression were significantly higher in long bones as compared with jaws OS, whereas there was no significant difference regarding the P53 expression between jaws and long bones OS.


CONCLUSIONS
Jaws and long bones OS bear a comparable cell cycle dysregulation when quantified with P53 immunostaining, whereas the long bones OS have a higher proliferative and angiogenic capacity than their jaw counterparts when evaluated with Ki-67 and VEGF immunoexpressions respectively.
Jawad
Salam N
SN
Department of Oral Pathology, College of Dentistry, Baghdad University, Baghdad, Iraq. dr_salam80@yahoo.com
Abdullah
Bashar H
BH
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D017209:Apoptosis; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D016009:Chi-Square Distribution; D019902:Chondrocytes / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000378:metabolism / Q000473:pathology*; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D009389:Neovascularization, Pathologic; D010006:Osteoblasts / Q000473:pathology; D012516:Osteosarcoma / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A