title: Successful right hepatectomy after four treatments of yttrium-90 microspheres (SIR-Spheres) and concomitant FOLFOX as bridging therapy to resection of colorectal liver metastases.
abstract: The use of yttrium-90 microspheres is a novel interventional radiological procedure that has delivered promising results in the treatment of liver cancer. Multiple treatments in combination with systemic chemotherapy may be realised as an effective modality for unresectable colorectal liver metastases. This case study reports the first case of a patient who had a complete response of 7 out of 10 liver metastases following multiple doses of yttrium-90 microsphere therapy, who then underwent a curative hepatic resection. This case demonstrates the feasibility and potential use of this management strategy to expand the role of successful therapies that will bridge the road towards curative liver resection.
authors.affiliation: University of New South Wales, Department of Surgery, St George Hospital, Kogarah, NSW 2217, Sydney, Australia. terence.chua@unsw.edu.au
authors.forename: Terence C
authors.initials: TC
authors.lastname: Chua
authors.forename: Lourens
authors.initials: L
authors.lastname: Bester
authors.forename: Javed
authors.initials: J
authors.lastname: Akther
authors.forename: David L
authors.initials: DL
authors.lastname: Morris
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D018714:Radiotherapy, Adjuvant; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
chemical_list: D009944:Organoplatinum Compounds; D015021:Yttrium Radioisotopes; D002955:Leucovorin; D005472:Fluorouracil