title: Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified Paclitaxel.
abstract: Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) is a classic example of this type of compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) that are PEGylated (PEG-HCCs) are effective drug delivery vehicles when simply mixed with paclitaxel. This formulation of PTX sequestered in PEG-HCCs (PTX/PEG-HCCs) is stable for at least 20 weeks. The PTX/PEG-HCCs formulation was as effective as PTX in a clinical formulation in reducing tumor volumes in an orthotopic murine model of oral squamous cell carcinoma. Preliminary toxicity and biodistribution studies suggest that the PEG-HCCs are not acutely toxic and, like many other nanomaterials, are primarily accumulated in the liver and spleen. This work demonstrates that carbon nanomaterials are effective drug delivery vehicles in vivo when noncovalently loaded with an unmodified drug.
authors.affiliation: Department of Chemistry, Rice University, MS-222, 6100 Main Street, Houston, Texas 77005, USA.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Berlin
authors.forename: Ashley D
authors.initials: AD
authors.lastname: Leonard
authors.forename: Tam T
authors.initials: TT
authors.lastname: Pham
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sano
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Marcano
authors.forename: Shayou
authors.initials: S
authors.lastname: Yan
authors.forename: Stefania
authors.initials: S
authors.lastname: Fiorentino
authors.forename: Zvonimir L
authors.initials: ZL
authors.lastname: Milas
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kosynkin
authors.forename: B Katherine
authors.initials: BK
authors.lastname: Price
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Lucente-Schultz
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Wen
authors.forename: M Gabriela
authors.initials: MG
authors.lastname: Raso
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Craig
authors.forename: Hai T
authors.initials: HT
authors.lastname: Tran
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Myers
authors.forename: James M
authors.initials: JM
authors.lastname: Tour
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000633:toxicity; D004355:Drug Stability; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry* / Q000633:toxicity; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D011092:Polyethylene Glycols; D002244:Carbon; D017239:Paclitaxel