title: Insight, grey matter and cognitive function in first-onset psychosis.
abstract: BACKGROUND
  Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures.
  
  
  OBJECTIVE
  Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis.
  
  
  METHODS
  Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight.
  
  
  RESULTS
  The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus.
  
  
  CONCLUSIONS
  The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
authors.affiliation: Department of Psychology, University of Westminster, 309 Regent Street, London W1B 2UW, UK. k.d.morgan@westminster.ac.uk
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Morgan
authors.forename: Paola
authors.initials: P
authors.lastname: Dazzan
authors.forename: Craig
authors.initials: C
authors.lastname: Morgan
authors.forename: Julia
authors.initials: J
authors.lastname: Lappin
authors.forename: Gerard
authors.initials: G
authors.lastname: Hutchinson
authors.forename: John
authors.initials: J
authors.lastname: Suckling
authors.forename: Paul
authors.initials: P
authors.lastname: Fearon
authors.forename: Peter B
authors.initials: PB
authors.lastname: Jones
authors.forename: Julian
authors.initials: J
authors.lastname: Leff
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Anthony S
authors.initials: AS
authors.lastname: David
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D002552:Cerebral Ventricles / Q000473:pathology; D003071:Cognition; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D055815:Young Adult