title: [Adhesion loss of syrups in a metering glass which consists of a low surface free energy material].
abstract: We previously reported a strong positive correlation between syrup viscosity and the rate of syrup loss due to adhesion to a glass metering device. In this study, we examined differences in the surface free energies of metering devices made of different polymeric materials, since reducing adhesion loss to metering devices could improve the efficiency of drug preparation involving highly viscous syrups. Among metering devices made of glass only, glass with a silicone coating (SLC), polypropylene (PP), and polymethylpentene (PMP) the surface free energy of the glass-only metering device was the highest (49.2 mN/m). The adhesion loss obtained for highly viscous syrups in the PP and PMP metering devices was significantly lower than that of the glass metering device. Measurements of syrup contact angles suggested that in metering devices made of PP and PMP, which have low surface free energies, a decrease in the spreading wetting of syrups was a factor in reducing the rate of adhesion loss. Thus irrespective of the syrup viscosity being measured, metering devices produced from materials with low surface free energies can reduce the time required to prepare prescriptions without compromising the accuracy of drug preparation.
authors.affiliation: Sakuragi Pharmacy, QOL Kanto Co. Ltd, Wakaba-ku, Chiba, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Toyofumi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kaname
authors.initials: K
authors.lastname: Hashizaki
authors.forename: Masao
authors.initials: M
authors.lastname: Ogura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Umeda
authors.forename: Shinji
authors.initials: S
authors.lastname: Hidaka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Fukami
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tomono
mesh_terms: D000328:Adult; D004339:Drug Compounding; D005260:Female; D005898:Glass; D006801:Humans; D008297:Male; D019999:Pharmaceutical Solutions / Q000032:analysis; D055585:Physical Phenomena; D011126:Polypropylenes; D012828:Silicones; D013499:Surface Properties; D014783:Viscosity
chemical_list: D019999:Pharmaceutical Solutions; D011126:Polypropylenes; D012828:Silicones