title: Antibiotic therapeutic options for infections caused by drug-resistant Gram-positive cocci.
abstract: Serious infections caused by Gram-positive bacteria are currently difficult to treat because many of these pathogens are now resistant to standard antimicrobial agents. As a result of the emergence and spread of multidrug-resistant Gram-positive pathogens, new antimicrobial agents are urgently needed for clinical use. In recent years, there has been an increase in the number of drugs that have activity against these Gram-positive pathogens. Daptomycin, tigecycline, linezolid, quinupristin/dalfopristin and dalbavancin are five antimicrobial agents that are useful for the treatment of infections due to drug-resistant Gram-positive cocci. This review focuses on their mechanism of action, pharmacokinetics, spectrum of activity, clinical effectiveness, drug interaction and safety. These antimicrobial agents provide the clinician with additional treatment options among the limited therapies for resistant Gram-positive bacterial infection.
authors.affiliation: Division of Microbiology, Department of Laboratory Medicine, Amiri Hospital, Safat, Kuwait.
authors.forename: K
authors.initials: K
authors.lastname: Banwan
authors.forename: A C
authors.initials: AC
authors.lastname: Senok
authors.forename: V O
authors.initials: VO
authors.lastname: Rotimi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents