Palisaded encapsulated neuroma: an entity to consider in the differential diagnosis of the eyelid nodule. A case report.
A 58-year-old female presented to her ophthalmologist with a firm 5 mm × 5 mm painless nodule on her right eyelid that had been present for 4 years. The nodule was well encapsulated and was composed of spindled cells. The central portion of the tumor contained a neuroid cell population with tapered ends. The periphery of the neuroid cell population exhibited a palisading pattern. Myxoid stromal changes could be appreciated between the neuroid cell population and the capsule. Routine hematoxylin-eosin staining and S100, epithelial membrane antigen, and neurofilament were used to diagnose the nodule as palisaded and encapsulated neuroma, a benign peripheral nerve sheath tumor derived from Schwann cells.
Messner
Katherine S
KS
Pathology Department, University of Illinois, Chicago, IL 60612-7335, USA. kmessner@uic.edu
Braniecki
Marylee
M
D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D016900:Neurofilament Proteins / Q000032:analysis; D009463:Neuroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000473:pathology
D018396:Mucin-1; D016900:Neurofilament Proteins; D009418:S100 Proteins