Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report.
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of T-cell lymphoma of CD3+CD8+ phenotype characterized by deep-seated skin nodules or plaques mimicking panniculitis, a result of neoplastic lymphocytes infiltrating the subcutaneous fatty tissue. We present a case of a 19-month year old boy with SPTCL diagnosed and successfully treated in our institution. Disease first presented with symptoms of high fever and painful erythematous nodule located below the umbilicus. Later on the infiltrates appeared on the face, legs, arms and the back of the body. As the most decisive in obtaining the diagnosis, skin biopsy showed atypical, small to medium-sized lymphatic cells infiltrating the deeper dermal layers as well as the subcutaneous adipous tissue surrounding the adipocytes. Immunohystochemical analysis showed neoplastic lymphocytes positive for CD2, CD3, CD5, CD7, CD8, Tia-1, granzyme B and perforine, and negative for CD20, CD34, TDT and CD56. No infiltration of blood vessels or epidermis was evident. Specific T-cell lymphomas protocol (EURO-LB 02) was then initiated which resulted with rapid regression of all general and local symptoms. The treatment was completed according to schedule and the child is now, 24 months after the initiation of the treatment, in complete remission.
Rajić
Ljubica
L
Department of Haematology and Oncology, Pediatric Clinic, Zagreb University Hospital Center, Zagreb, Croatia. ljubica.rajic@yahoo.com
Bilić
Ernest
E
Femenić
Ranka
R
Mestrović
Daniel
D
Ilić
Ivana
I
Lasan-Trcić
Ruzica
R
Dubravcić
Klara
K
Husar
Karmela
K
Kardum-Skelin
Ika
I
Tesović
Goran
G
Culig
Zdravka
Z
Konja
Josip
J
D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003937:Diagnosis, Differential; D004890:Erythema / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D015434:Panniculitis / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology
D015703:Antigens, CD; D015122:Mercaptopurine; D008727:Methotrexate