title: Residual tumor cells are unique cellular targets in glioblastoma.
abstract: Residual tumor cells remain beyond the margins of every glioblastoma (GBM) resection. Their resistance to postsurgical therapy is considered a major driving force of mortality, but their biology remains largely uncharacterized. In this study, residual tumor cells were derived via experimental biopsy of the resection margin after standard neurosurgery for direct comparison with samples from the routinely resected tumor tissue. In vitro analysis of proliferation, invasion, stem cell qualities, GBM-typical antigens, genotypes, and in vitro drug and irradiation challenge studies revealed these cells as unique entities. Our findings suggest a need for characterization of residual tumor cells to optimize diagnosis and treatment of GBM.
authors.affiliation: Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Germany. martin.glas@ukb.uni-bonn.de
authors.forename: Martin
authors.initials: M
authors.lastname: Glas
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Rath
authors.forename: Matthias
authors.initials: M
authors.lastname: Simon
authors.forename: Roman
authors.initials: R
authors.lastname: Reinartz
authors.forename: Anja
authors.initials: A
authors.lastname: Schramme
authors.forename: Daniel
authors.initials: D
authors.lastname: Trageser
authors.forename: Ramona
authors.initials: R
authors.lastname: Eisenreich
authors.forename: Anke
authors.initials: A
authors.lastname: Leinhaas
authors.forename: Mihaela
authors.initials: M
authors.lastname: Keller
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Schildhaus
authors.forename: Stephan
authors.initials: S
authors.lastname: Garbe
authors.forename: Barbara
authors.initials: B
authors.lastname: Steinfarz
authors.forename: Torsten
authors.initials: T
authors.lastname: Pietsch
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Steindler
authors.forename: Johannes
authors.initials: J
authors.lastname: Schramm
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger
authors.forename: Oliver
authors.initials: O
authors.lastname: Brüstle
authors.forename: Björn
authors.initials: B
authors.lastname: Scheffler
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D018929:Cell Culture Techniques; D049109:Cell Proliferation; D002469:Cell Separation; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm