title: Whole-body diffusion-weighted imaging for staging malignant lymphoma in children.
abstract: CT is currently the mainstay in staging malignant lymphoma in children, but the risk of second neoplasms due to ionizing radiation associated with CT is not negligible. Whole-body MRI techniques and whole-body diffusion-weighted imaging (DWI) in particular, may be a good radiation-free alternative to CT. DWI is characterized by high sensitivity for the detection of lesions and allows quantitative assessment of diffusion that may aid in the evaluation of malignant lymphomas. This article will review whole-body MRI techniques for staging malignant lymphoma with emphasis on whole-body DWI. Furthermore, future considerations and challenges in whole-body DWI will be discussed.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. thomaskwee@gmail.com
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Kwee
authors.forename: Taro
authors.initials: T
authors.lastname: Takahara
authors.forename: Malou A
authors.initials: MA
authors.lastname: Vermoolen
authors.forename: Marc B
authors.initials: MB
authors.lastname: Bierings
authors.forename: Willem P
authors.initials: WP
authors.lastname: Mali
authors.forename: Rutger A J
authors.initials: RA
authors.lastname: Nievelstein
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D007223:Infant; D008223:Lymphoma / Q000175:diagnosis*; D009367:Neoplasm Staging / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods