title: Preliminary comparison of tumor biologic factors in breast carcinomas from Australian and Chinese women.
abstract: OBJECTIVE
  To compare the morphologic and immunohistochemical properties of breast carcinomas from Chinese and Australian women in order to define possible biologic differences between these carcinomas.
  
  
  METHODS
  Three hundred cases of breast carcinomas were assessed for histologic and immunophenotypic characteristics from the pathology archives of the Changhai and St. Vincent's Hospitals.
  
  
  RESULTS
  The Chinese women had proportionally more grade 2 and 3 tumors, whereas Australian women had a higher proportion of grade 1 tumor. There was a higher proportion of younger patients with a larger tumor and patients with lymph node involvement in the Chinese group as compared with Australian women. There was no difference in rate of estrogen receptor positive tumors between the 2 groups. p53 Expression was statistically more common with less cyclin D1 expression in Chinese as compared with Australian women.
  
  
  CONCLUSIONS
  This study indicates that both inherent tumor biology and stage at presentation influence adversely affect the outcome of breast carcinoma in Chinese compared as with Australian women.
authors.affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China. zhengdoctor@hotmail.com
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Zheng
authors.forename: Jane E
authors.initials: JE
authors.lastname: Armes
authors.forename: John
authors.initials: J
authors.lastname: Slavin
authors.forename: Yuzhao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Canrong
authors.initials: C
authors.lastname: Ni
mesh_terms: D044466:Asian People; D001315:Australia / Q000453:epidemiology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000208:ethnology* / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000208:ethnology* / Q000378:metabolism* / Q000473:pathology; D002681:China / Q000453:epidemiology; D019938:Cyclin D1 / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D044465:White People
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1