title: [Treatment of circumscribed choroidal haemangiomas by photodynamic therapy: a review].
abstract: Circumscribed choroidal hemangioma (CCH) is an uncommon benign vascular tumor of the choroid that is usually diagnosed when it causes a decrease in vision due to exudative retinal detachment. The classical treatments of CCH were photocoagulation and radiotherapy, which induced additional chorioretinal damage, explaining the poor visual prognosis even in adequately treated patients. It is difficult to compare these two therapeutic options, laser photocoagulation having been abandoned for many years due to the retractile retinal scars that it induced. Conventional radiotherapy and proton therapy with a total dose of 20 Gy gave and give good results but can be performed only by teams used to these types of treatment. Recently, photodynamic therapy (PDT), which allows a selective occlusion of vascular lesions without damaging overlying retinal structures, has emerged as a sound alternative for the treatment of CCH. Most of the clinicians used the standard treatment of age related macular degeneration by photodynamic therapy (TAP) study protocol with or without variations. The main variations brought to the TAP study protocol were the duration of the verteporfin infusion, and/or the increase of the laser power settings, and/or the increase of the duration of exposure, and/or the number of PDT spots (single spot or multiple spots, overlapping or not). Mid-term PDT results are very encouraging. PDT has been reported to bring about resolution of subretinal fluid and to reduce tumor thickness in almost all cases. Visual acuity was improved or stabilized in at least 80% of the cases. Several studies reported on minor local side effects following PDT, consisting of atrophy and proliferation of the retinal pigment epithelium, atrophy of the choroid, transient choroidal effusion, and mild subretinal fibrosis. Published data demonstrated that PDT is a safe and effective alternative to radiotherapy or photocoagulation as first-line therapy for CCH.
authors.affiliation: Service d'ophtalmologie, hôpital Morvan, 5, avenue Foch, 29609 Brest cedex, France. joel.gambrelle@hotmail.fr
authors.forename: J
authors.initials: J
authors.lastname: Gambrelle
authors.forename: C
authors.initials: C
authors.lastname: Graswill
authors.forename: M
authors.initials: M
authors.lastname: Mauget-Faysse
authors.forename: L
authors.initials: L
authors.lastname: Kodjikian
authors.forename: B
authors.initials: B
authors.lastname: Cochener
authors.forename: J-D
authors.initials: JD
authors.lastname: Grange
mesh_terms: D002830:Choroid Neoplasms / Q000188:drug therapy*; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy