Symmetry and dynamics of molecular rotors in amphidynamic molecular crystals.
Rotary biomolecular machines rely on highly symmetric supramolecular structures with rotating units that operate within a densely packed frame of reference, stator, embedded within relatively rigid membranes. The most notable examples are the enzyme FoF1 ATP synthase and the bacterial flagellum, which undergo rotation in steps determined by the symmetries of their rotators and rotating units. Speculating that a precise control of rotational dynamics in rigid environments will be essential for the development of artificial molecular machines, we analyzed the relation between rotational symmetry order and equilibrium rotational dynamics in a set of crystalline molecular gyroscopes with rotators having axial symmetry that ranges from two- to fivefold. The site exchange frequency for these molecules in their closely related crystals at ambient temperature varies by several orders of magnitude, up to ca. 4.46 x 10(8) s(-1).
Karlen
Steven D
SD
Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA.
Reyes
Horacio
H
Taylor
R E
RE
Khan
Saeed I
SI
Hawthorne
M Frederick
MF
Garcia-Garibay
Miguel A
MA
D000480:Alkynes / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D055598:Chemical Phenomena; D003460:Crystallization; D018360:Crystallography, X-Ray; D046911:Macromolecular Substances / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D012399:Rotation
D000480:Alkynes; D001643:Bridged Bicyclo Compounds; D046911:Macromolecular Substances