title: The role of animal models in advancing amyloid-beta immunotherapy to the clinic.
abstract: The amyloid-beta (Aβ) hypothesis of Alzheimer's disease (AD) causality is now well into its third decade and is finally entering a phase of rigorous clinical testing in numerous late stage clinical trials. The use of Aβ-based animal models of AD has been essential to the discovery and/or preclinical validation of many of these therapeutic approaches. While several neuropathologically based results from preclinical studies have translated nicely into AD patients, the full clinical value of Aβ-directed therapies awaits results from trials now in progress.
authors.affiliation: Janssen Alzheimer Immunotherapy Research and Development, LLC, 700 Gateway, Blvd, South San Francisco, CA 94080, USA. Dora.Games@neotopebio.com.
authors.forename: Dora
authors.initials: D
authors.lastname: Games
authors.forename: Peter
authors.initials: P
authors.lastname: Seubert