title: Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients.
abstract: BACKGROUND
  The peak incidence of glioblastoma multiforme (GBM) occurs in those aged 65 years and older. However, studies on this patient group remain limited. The goal of this study is to evaluate the efficacy of surgery versus biopsy for older patients with these lesions.
  
  
  METHODS
  133 and 72 consecutive patients aged 65 years and older who underwent surgery and needle biopsy for intracranial primary (de novo) GBM between 1997 and 2007 were retrospectively reviewed. Among these patients, 40 who underwent surgical resection were matched with 40 who underwent needle biopsy alone for factors consistently shown to be associated with survival [age, Karnofsky Performance Scale (KPS) indexing, eloquent involvement, radiation, temozolomide]. Survival was expressed as estimated Kaplan-Meier plots, and log-rank analysis was used to compare survival curves.
  
  
  RESULTS
  Mean ± standard deviation age was 73 ± 5 years, and median survival was 4.9 months. There were no significant differences in perioperative outcomes among patients who underwent surgical resection versus needle biopsy. Patients who underwent resection had median survival of 5.7 months as compared with 4.0 months for patients who underwent needle biopsy (P = 0.02). Likewise, for patients aged 70 years and older, median survival was 4.5 months for 26 patients who underwent surgical resection as compared with 3.0 months for 26 patients who underwent needle biopsy (P = 0.03).
  
  
  CONCLUSIONS
  This study demonstrates that older patients tolerate aggressive surgery without increased surgery-related morbidity and have prolonged survival as compared with similar patients undergoing needle biopsy. These findings may help guide treatment decisions for patients, their families, and their physicians.
authors.affiliation: The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Department of Neurosurgery, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA. kaisorn@jhmi.edu
authors.forename: Kaisorn L
authors.initials: KL
authors.lastname: Chaichana
authors.forename: Tomas
authors.initials: T
authors.lastname: Garzon-Muvdi
authors.forename: Scott
authors.initials: S
authors.lastname: Parker
authors.forename: Jon D
authors.initials: JD
authors.lastname: Weingart
authors.forename: Alessandro
authors.initials: A
authors.lastname: Olivi
authors.forename: Richard
authors.initials: R
authors.lastname: Bennett
authors.forename: Henry
authors.initials: H
authors.lastname: Brem
authors.forename: Alfredo
authors.initials: A
authors.lastname: Quiñones-Hinojosa
mesh_terms: D000368:Aged; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D019990:Perioperative Care; D011379:Prognosis; D012189:Retrospective Studies; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate