title: Rapidly growing orf in a renal transplant recipient: favourable outcome with reduction of immunosuppression and imiquimod.
abstract: Orf is a viral skin infection due to a poxvirus. It manifests as a nodule of the hands that heals spontaneously within 3-4 weeks, but may be persisting and difficult to treat in immunocompromised patients. Very few cases have been reported in transplant patients; therefore, management is not established. We report a renal transplant recipient with a rapidly growing orf which regressed after application of imiquimod and a reduction in immunosuppression without damage on his renal function. This case suggests that a rapidly growing orf in transplant patients behaves as an opportunistic infection and therefore minimization should be considered along with a topical treatment.
authors.affiliation: Department of Dermatology, Edouard Herriot Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: Daniela
authors.initials: D
authors.lastname: Zaharia
authors.forename: Jean
authors.initials: J
authors.lastname: Kanitakis
authors.forename: Claire
authors.initials: C
authors.lastname: Pouteil-Noble
authors.forename: Sylvie
authors.initials: S
authors.lastname: Euvrard
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D004474:Ecthyma, Contagious / Q000188:drug therapy*; D005385:Fingers; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy; D012756:Sheep; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D007166:Immunosuppressive Agents; D000077271:Imiquimod