title: The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship.
abstract: We found renin inhibitory activity in rice. The physico-chemical data on the isolated inhibitors were identical to those of oleic acid and linoleic acid. Oleic acid and linoleic acid competitively inhibited renin activity, with K(i) values of 15.8 and 19.8 microM respectively. Other unsaturated free fatty acids also inhibited renin activity, but saturated fatty acids had no effect on it.
authors.affiliation: Akita Research Institute of Food and Brewing, Sanuki, Arayamachi, Akita, Japan. saori@arif.pref.akita.jp
authors.forename: Saori
authors.initials: S
authors.lastname: Takahashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tokiwano
authors.forename: Keishi
authors.initials: K
authors.lastname: Hata
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kodama
authors.forename: Mika
authors.initials: M
authors.lastname: Hokari
authors.forename: Nao
authors.initials: N
authors.lastname: Suzuki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Gotoh
mesh_terms: D020128:Inhibitory Concentration 50; D019787:Linoleic Acid / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019301:Oleic Acid / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012275:Oryza / Q000737:chemistry*; D011480:Protease Inhibitors / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D000092502:Renin Inhibitors
chemical_list: D019787:Linoleic Acid; D019301:Oleic Acid; D011480:Protease Inhibitors; D000092502:Renin Inhibitors