title: Extramammary Paget's disease with the appearance of a nodule: a case report.
abstract: BACKGROUND
  Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease.
  
  
  METHODS
  We here report a case of primary EMPD with the appearance of a nodule on the background of erythema. Histological assessment showed Paget cell infiltration throughout the epidermis with dermal spread. Using immunohistochemistry, the expressions of CK7, CK19, CK20, GCDFP-15, CEA, S-100 protein and bcl-2 were examined to elucidate the cellular differentiation of the carcinoma.
  
  
  CONCLUSIONS
  According to the histological assessment, this case was diagnosed as primary EMPD with carcinoma cells invading into the dermis, but without lymph node infiltration.
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, P. R. China. wenliny@21cn.com
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Wenlin
authors.initials: W
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D004817:Epidermis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D014845:Vulvar Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor