Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
Thye
Thorsten
T
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.|Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Vannberg
Fredrik O
FO
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Wong
Sunny H
SH
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Owusu-Dabo
Ellis
E
Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.|Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Osei
Ivy
I
Health Research Unit, Ghana Health Service, Accra, Ghana.
Gyapong
John
J
Health Research Unit, Ghana Health Service, Accra, Ghana.
Sirugo
Giorgio
G
MRC Laboratories, Fajara, Banjul, The Gambia.
Sisay-Joof
Fatou
F
MRC Laboratories, Fajara, Banjul, The Gambia.
Enimil
Anthony
A
Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.|Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Chinbuah
Margaret A
MA
Health Research Unit, Ghana Health Service, Accra, Ghana.
Floyd
Sian
S
London School of Hygiene and Tropical Medicine, London, United Kingdom.
Warndorff
David K
DK
Karonga Prevention Study, Chilumba, Karonga District, Malawi.
Sichali
Lifted
L
Karonga Prevention Study, Chilumba, Karonga District, Malawi.
Malema
Simon
S
Karonga Prevention Study, Chilumba, Karonga District, Malawi.
Crampin
Amelia C
AC
London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ngwira
Bagrey
B
Karonga Prevention Study, Chilumba, Karonga District, Malawi.
Teo
Yik Y
YY
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Small
Kerrin
K
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Rockett
Kirk
K
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Kwiatkowski
Dominic
D
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Fine
Paul E
PE
London School of Hygiene and Tropical Medicine, London, United Kingdom.|Karonga Prevention Study, Chilumba, Karonga District, Malawi.
Hill
Philip C
PC
MRC Laboratories, Fajara, Banjul, The Gambia.
Newport
Melanie
M
MRC Laboratories, Fajara, Banjul, The Gambia.
Lienhardt
Christian
C
MRC Laboratories, Fajara, Banjul, The Gambia.
Adegbola
Richard A
RA
MRC Laboratories, Fajara, Banjul, The Gambia.
Corrah
Tumani
T
MRC Laboratories, Fajara, Banjul, The Gambia.
Ziegler
Andreas
A
Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Morris
Andrew P
AP
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Meyer
Christian G
CG
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Horstmann
Rolf D
RD
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Hill
Adrian V S
AVS
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
D016022:Case-Control Studies; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D005714:Gambia; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D005869:Ghana; D006801:Humans; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics*