Cerebrospinal fluid insulin during non-neurological surgery.
Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.
Bromander
Sara
S
Forensic Psychiatry, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anckarsäter
Rolf
R
Ahrén
Bo
B
Kristiansson
Marianne
M
Blennow
Kaj
K
Holmäng
Agneta
A
Zetterberg
Henrik
H
Anckarsäter
Henrik
H
Wass
Caroline E
CE
D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier / Q000502:physiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000134:cerebrospinal fluid*; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects*; D011183:Postoperative Complications / Q000097:blood / Q000134:cerebrospinal fluid* / Q000209:etiology; D013312:Stress, Physiological / Q000502:physiology
D007328:Insulin