title: Actin-based motility of Burkholderia thailandensis requires a central acidic domain of BimA that recruits and activates the cellular Arp2/3 complex.
abstract: Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.
authors.affiliation: Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.
authors.forename: Chayada
authors.initials: C
authors.lastname: Sitthidet
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Stevens
authors.forename: Terence R
authors.initials: TR
authors.lastname: Field
authors.forename: Abigail N
authors.initials: AN
authors.lastname: Layton
authors.forename: Sunee
authors.initials: S
authors.lastname: Korbsrisate
authors.forename: Mark P
authors.initials: MP
authors.lastname: Stevens
mesh_terms: D000199:Actins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D019117:Burkholderia / Q000235:genetics / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D018613:Microscopy, Confocal
chemical_list: D000199:Actins; D001426:Bacterial Proteins; D008840:Microfilament Proteins