title: Role of tissue factor in venous thrombosis.
abstract: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide. However, the mechanisms by which clots are formed in the deep veins have not been determined. Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into the circulation on small-membrane vesicles termed microparticles (MPs). Recent studies suggest that elevated levels of MP TF may trigger thrombosis. This review provides an overview of the role of TF in VTE.
authors.affiliation: Brody School of Medicine, East Caroline University, Greenville, North Carolina 27834, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Manly
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Boles
authors.forename: Nigel
authors.initials: N
authors.lastname: Mackman
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000502:physiology; D055252:Cell-Derived Microparticles / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology; D013925:Thromboplastin / Q000096:biosynthesis / Q000502:physiology*; D020246:Venous Thrombosis / Q000503:physiopathology* / Q000601:surgery; D014947:Wounds and Injuries / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D013925:Thromboplastin