title: A highly sensitive non-enzymatic glucose sensor based on a simple two-step electrodeposition of cupric oxide (CuO) nanoparticles onto multi-walled carbon nanotube arrays.
abstract: A novel, stable and highly sensitive non-enzymatic glucose (Glc) sensor was developed using vertically well-aligned multi-walled carbon nanotubes array (MWCNTs) incorporated with cupric oxide (CuO) nanoparticles. The MWCNTs array was prepared by catalytic chemical vapor deposition on a tantalum (Ta) substrate, while a simple and rapid two-step electrodeposition technique was used to prepare the CuO-MWCNTs nanocomposite. First, Cu nanoparticles were deposited onto MWCNTs at constant potential and then they were oxidized into CuO by potential cycling. The electrocatalytic activity of CuO-MWCNTs array was investigated for Glc under alkaline conditions using cyclic voltammetry and chronoamperometry. The sensor exhibited a linear response up to 3 mM of Glc and sensitivity of 2190 microA mM(-1) cm(-2), which is two to three orders of magnitude higher than that of most non-enzymatic Glc sensors reported in the literature. The sensor response time is less than 2s and detection limit is 800 nM (at signal/noise=3). When tested with human blood serum samples, the sensor exhibited high electrocatalytic activity, stability, fast response and good selectivity against common interfering species, suggesting its potential to be developed as a non-enzymatic Glc sensor.
authors.affiliation: Department of Biological Systems Engineering, University of Wisconsin-Madison, 460 Henry Mall, Madison, WI 53706, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Yang
authors.forename: Liao-Chuan
authors.initials: LC
authors.lastname: Jiang
authors.forename: Wei-De
authors.initials: WD
authors.lastname: Zhang
authors.forename: Sundaram
authors.initials: S
authors.lastname: Gunasekaran
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D004563:Electrochemistry; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D013499:Surface Properties
chemical_list: D001786:Blood Glucose; D037742:Nanotubes, Carbon; D003300:Copper; D005947:Glucose; C030973:cupric oxide