[Formula screening and optimizing for the dispersible tablets of breviscapine by orthogonal experiment].
OBJECTIVE
To establish a suitable formulation for the dispersible tablets of brevisicapine.


METHODS
To prepare and optimize the breviscapine dispersible tablets by orthogonal experiment design using disintegration time as the index. The quality of breviscapine dispersible tablets was evaluated by the initial stability test.


RESULTS
The disintegration time of optimized prescription formulation was 89 s. L-HPC and CMS-Na were used by combining exterior and interior and the dissolution percent in vitro was obviously superior to the conventional tablets, and the quality of the dispersible tablets was very good in stability test.


CONCLUSIONS
The formulation screened out for the dispersible tablets of breviscapine is reasonable, stable and suitable for the production on a large scale.
Ding
Yan
Y
Department of Pharmacy, Shandong University, Jinan 250012, China. dyanan1696@sina.com
Huang
Gui-Hua
GH
D000925:Anticoagulants / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry; D049919:Erigeron / Q000737:chemistry*; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005079:Excipients; D005419:Flavonoids; D013607:Tablets; C061097:breviscapine