title: Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma.
abstract: OBJECTIVE
  The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG).
  
  
  METHODS
  This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes.
  
  
  RESULTS
  IOP values were significantly reduced at individual time points after treatment (P < 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean +/- SD) were 12.9 +/- 2.2 mmHg, 15.4 +/- 2.7 mmHg, 10.5 +/- 2.2 mmHg, and 4.9 +/- 1.2 mmHg, respectively, and were significantly reduced to 10.3 +/- 2.0 mmHg, 12.4 +/- 2.5 mmHg, 8.5 +/- 1.9 mmHg (all P < 0.001), and 3.9 +/- 1.5 mmHg (P < 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP.
  
  
  CONCLUSIONS
  Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nomura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Nakakura
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Moriwaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Shiraki