title: [Primary neurolymphomatosis of the cervical nerve root].
abstract: A 74-year-old woman was admitted with muscle weakness and sharp pain in her upper limbs. On (18)FDG-PET, abnormal accumulation was noted on both sides of the brachial plexus at the cervical spinal cord. A diagnosis of primary peripheral nerve neurolymphomatosis was made based on biopsy of the third cervical nerve. Following R-CHOP therapy, the abnormal accumulation of (18)FDG-PET scan disappeared. However, disturbance of consciousness occurred 6 months later and recurrence as multiple brain tumors was detected. Although salvage chemotherapy was performed, the patient died of overwhelming sepsis. Primary peripheral nerve neurolymphomatosis is extremely rare. Early distinct diagnosis using (18)FDG-PET and combination chemotherapy of rituximab and high dose methotrexate may improve the outcome for such patients.
authors.affiliation: Department of Hematology and Immunology, Kanazawa Medical University.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Miki
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Masaki
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakamura
authors.forename: Haruka
authors.initials: H
authors.lastname: Iwao
authors.forename: Akio
authors.initials: A
authors.lastname: Nakajima
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Sakai
authors.forename: Toshioki
authors.initials: T
authors.lastname: Sawaki
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kawanami
authors.forename: Muichi
authors.initials: M
authors.lastname: Kaito
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kurose
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Fujita
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fukushima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hisanori
authors.initials: H
authors.lastname: Umehara
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002574:Cervical Vertebrae; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000628:therapy*; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000008:administration & dosage; D000069283:Rituximab; D013126:Spinal Nerve Roots; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D008727:Methotrexate