title: Differential effects of stress on [¹¹C]raclopride and [¹¹C]MNPA binding to striatal D₂/D₃ dopamine receptors: a PET study in conscious monkeys.
abstract: It has been reported that stress and facilitation of dopamine neuronal system are closely related. In the present study, the effects of stress on the binding of antagonist-based [¹¹C]raclopride and agonist-based (R)-2-CH3O-N-n- propylnorapomorphine ([¹¹C]MNPA) to D₂/D₃ receptors were evaluated in the striatum of conscious monkey brain. The stress state assessed from plasma cortisol level was negatively correlated with [¹¹C]raclopride binding as expected. It was noteworthy that [¹¹C]MNPA binding exhibited a positive correlation with stress state; thus, the animals with higher cortisol levels showed higher binding to D₂/D₃ receptors.
authors.affiliation: Central Research Laboratory, Hamamatsu Photonics K.K., Hamakita, Hamamatsu, Shizuoka, Japan. tsukada@crl.hpk.co.jp
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsukada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohba
authors.forename: Shingo
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kakiuchi
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000378:metabolism* / Q000494:pharmacology; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000378:metabolism* / Q000494:pharmacology; D006854:Hydrocortisone / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D049268:Positron-Emission Tomography; D020891:Raclopride / Q000378:metabolism* / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D002250:Carbon Radioisotopes; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D020891:Raclopride; D001058:Apomorphine; D006854:Hydrocortisone