title: Efficacy of mulberry leaf tablets in patients with mild dyslipidemia.
abstract: Mulberry leaf is well known for its several biological effects. The purpose of this study was to evaluate the hypolipidemic effect of mulberry leaf in non-diabetic patients with mild dyslipidemia. A within-subjects research design was conducted at the out-patient clinic in Thailand. Twenty-three patients who met the NCEP ATP III criteria guideline for dyslipidemia and failed a 4 week diet therapy were enrolled and assigned to receive three tablets of 280 mg mulberry leaf tablet three times a day before meals for a period of 12 weeks. Routine blood analyses including lipid parameters and liver function tests were performed every 4 weeks. At 4 and 8 weeks of mulberry leaf tablet therapy, triglyceride was significantly decreased by 10.2% (p < 0.05) and 12.5% (p < 0.05), respectively, from baseline. At the end of the study, total cholesterol, triglyceride and LDL were significantly decreased by 4.9% (p < 0.05), 14.1% (p < 0.05) and 5.6% (p < 0.05), respectively, from baseline, whereas HDL was significantly increased by 19.7% (p < 0.05). Even though some patients experienced side effects such as mild diarrhea (26%), dizziness (8.7%) or constipation and bloating (4.3%), mulberry leaf tablet therapy is still capable and safe in reducing cholesterol levels and enhancing HDL in patients with mild dyslipidemia.
authors.affiliation: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. aramwit@gmail.com
authors.forename: Pornanong
authors.initials: P
authors.lastname: Aramwit
authors.forename: Kanokwan
authors.initials: K
authors.lastname: Petcharat
authors.forename: Ouppatham
authors.initials: O
authors.lastname: Supasyndh
mesh_terms: D000328:Adult; D050171:Dyslipidemias / Q000178:diet therapy / Q000188:drug therapy*; D002149:Energy Intake; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D031625:Morus / Q000737:chemistry*; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D013607:Tablets / Q000008:administration & dosage / Q000627:therapeutic use; D013785:Thailand
chemical_list: D000960:Hypolipidemic Agents; D013607:Tablets