title: Short-term weight loss in overweight/obese low-income women improves plasma zinc and metabolic syndrome risk factors.
abstract: Metabolic syndrome is a group of disorders involving obesity, insulin resistance, dyslipidemia and hypertension. Obesity is the most crucial risk factor of metabolic syndrome, because it is known to precede other risk factors. Obesity is also associated with disturbances in the metabolism of the trace mineral, zinc. The overall purpose of this study was to investigate the effects of short-term weight loss on plasma zinc and metabolic syndrome risk factors. An 8-week weight loss intervention study was conducted with 90 low-income overweight/obese mothers, whose youngest child was 1-3 years old. Plasma levels of zinc, glucose, insulin, leptin, triglycerides, total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were measured and compared at weeks 0 and 8 of the weight loss program. At pre-study, plasma zinc was low in 39% and, within normal values in 46%, of obese/overweight mothers. By the end of intervention, plasma zinc rose by 22% and only 5% of the mothers continued to exhibit low plasma zinc. At post-study, the metabolic syndrome risk factors of waist circumference, HDL cholesterol, and diastolic blood pressure (p<0.05) showed significant improvements. Plasma zinc increased by a greater margin (67%) in women with low zinc, as compared to those with normal zinc (18%); weight reduction was similar in both the groups. Finally, changes in % body fat were related negatively with changes in plasma zinc (r=- 0.28, p<0.05). The circulating levels of zinc, as well as the metabolic syndrome components, showed significant improvements in overweight/obese low-income women after weight loss.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA. svorugan@sfbrgenetics.org
authors.forename: Venkata Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: Guowen
authors.initials: G
authors.lastname: Cai
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Klohe
authors.forename: Kristine C
authors.initials: KC
authors.lastname: Jordan
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lane
authors.forename: Jeanne H
authors.initials: JH
authors.lastname: Freeland-Graves
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000628:therapy*; D050177:Overweight / Q000097:blood* / Q000628:therapy*; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult; D015032:Zinc / Q000097:blood*
chemical_list: D015032:Zinc