title: Effect of hyoscine butylbromide (HBB) on the uterine corpus: quantitative assessment with T2-weighted (T2W) MRI in healthy volunteers.
abstract: OBJECTIVE
  To investigate effects of hyoscine butylbromide (HBB) on the appearance of three zonal anatomy of the uterine corpus on T2-weighted images (T2WI).
  
  
  METHODS
  Sagittal T2WI of the pelvis were acquired before and after intramuscular administration of HBB with interval of 10 minutes in 22 healthy volunteers. By drawing polygonal regions of interest (ROIs), the uterine corpus was delineated into outer myometrium (OM), junctional zone (JZ), and endometrium (EM) in 20 subjects. Areas (mm(2)) and relative signal intensity (rSI) of each layer were compared between pre-HBB and post-HBB administration images by using paired t-tests. Histogram analysis was conducted for the uterine layers and changes were visualized.
  
  
  RESULTS
  Areas of OM were significantly increased (P = 0.014) and mean rSI of JZ and OM were significantly increased (P = 0.007 and 0.001, respectively) after administration of HBB. Histogram showed an increase in the number of pixels with higher rSI in the OM, which was considered to be caused by an increase in interstitial fluid and vascular dilatation. EM did not show significant changes.
  
  
  CONCLUSIONS
  Layer-wise ROI analyses demonstrated changes in the area and rSI in T2WI of the uterus after HBB administration. Histogram analysis contributed to the investigation of signal changes.
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. kfb@kuhp.kyoto-u.ac.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Asako
authors.initials: A
authors.lastname: Nakai
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Okada
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikeuchi
authors.forename: Naoe
authors.initials: N
authors.lastname: Satogami
authors.forename: Sayaka
authors.initials: S
authors.lastname: Daido
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yakami
authors.forename: Kaori
authors.initials: K
authors.lastname: Togashi
mesh_terms: D000328:Adult; D002086:Butylscopolammonium Bromide / Q000494:pharmacology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009215:Myometrium / Q000473:pathology; D015203:Reproducibility of Results; D014594:Uterine Neoplasms / Q000175:diagnosis; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
chemical_list: D002086:Butylscopolammonium Bromide