title: Evaluation of an edible blue-green alga, Aphanothece sacrum, for its inhibitory effect on replication of herpes simplex virus type 2 and influenza virus type A.
abstract: A hot-water extract of Aphanothece sacrum, an edible aquacultured blue-green alga, was found to show a remarkable inhibitory effect on the replication of enveloped viruses including herpes simplex virus type 2 (HSV-2) and influenza virus type A (IFV-A, H1N1) in vitro. The main active components were suggested to be sulfated polysaccharides in non-dialyzable portion (ASWPH). ASWPH was found to inhibit the viral adsorption to the receptor of the host cells involved in the replication process of HSV-2 and IFV-A. In addition, while the penetration stage of HSV-2 was also significantly suppressed with ASWPH, no such effect was observed in the replication of IFV-A. These results suggest that ASWPH might be useful in the prevention of infectious diseases caused by HSV-2 as well as IFV-A.
authors.affiliation: Graduate School of Medicine and Pharmaceutical Sciences for Research, Sugitani, Toyama, Japan.
authors.forename: Fumie
authors.initials: F
authors.lastname: Ogura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Jung-Bum
authors.initials: JB
authors.lastname: Lee
authors.forename: Kenji
authors.initials: K
authors.lastname: Kanekiyo
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000818:Animals; D005591:Chemical Fractionation; D002522:Chlorocebus aethiops; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000458:Cyanobacteria / Q000737:chemistry* / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D006358:Hot Temperature; D009980:Influenza A virus / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013464:Sulfuric Acids / Q000737:chemistry; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*; D014867:Water / Q000737:chemistry
chemical_list: D045424:Complex Mixtures; D011135:Polysaccharides, Bacterial; D013464:Sulfuric Acids; D014867:Water; C033158:sulfuric acid