title: Intrathecal chemotherapy in lymphomatous meningitis.
abstract: Central Nervous System (CNS) involvement in lymphoma can occur whether at diagnosis or, more often, at the progression or recurrence of disease and the most frequent clinical manifestation is lymphomatous meningitis (LM). The first risk factor for LM development is the histotype, with the highest incidence for highly aggressive non-Hodgkin's lymphomas (NHL) such as Burkitt's lymphoma (BL) and lymphoblastic lymphoma/acute lymphoblastic leukemia (LBL/ALL) and the lowest for indolent NHL. LM prophylaxis in aggressive NHL (other than BL and LBL/ALL) is a much debated question, because the identification of specific risk factors remains controversial. Moreover, there is not a consensus if the LM prophylaxis should consist of systemic chemotherapy (CT), intrathecal (i.t.) CT or both. In case of LM, the i.t. CT has a key role, but there is not a consensus on treatment schedule. Newer intensified regimens and rituximab lead to reconsider the whole approach to LM.
authors.affiliation: Istituto Oncologico Veneto IOV - IRCCS, Padova, Italy. canova1980@gmail.com
authors.forename: Fabio
authors.initials: F
authors.lastname: Canova
authors.forename: Dario
authors.initials: D
authors.lastname: Marino
authors.forename: Chiara
authors.initials: C
authors.lastname: Trentin
authors.forename: Caterina
authors.initials: C
authors.lastname: Soldà
authors.forename: Cristina
authors.initials: C
authors.lastname: Ghiotto
authors.forename: Savina Maria Luciana
authors.initials: SM
authors.lastname: Aversa
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016543:Central Nervous System Neoplasms / Q000556:secondary; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D007278:Injections, Spinal / Q000379:methods*; D017254:Leukemic Infiltration; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D008578:Meninges / Q000473:pathology*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D012307:Risk Factors; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone