Gene targeting and expression modulation by peptide nucleic acids (PNA).
Peptide nucleic acids (PNA) are artificial structural mimics of nucleic acids capable of sequence specific hybridization to both RNA and DNA. Thus they have obvious potential as gene targeting agents for drug discovery approaches. An overview with emphasis on recent progress on RNA "interference" (antisense), targeting of duplex DNA and gene targeted repair and transcription interference using PNA, as well as on PNA delivery and potential PNA anti-infectives is given.
Nielsen
Peter E
PE
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark. ptrn@sund.ku.dk
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods; D015195:Drug Design; D005786:Gene Expression Regulation / Q000187:drug effects*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D020135:Peptide Nucleic Acids / Q000494:pharmacology*; D016372:RNA, Antisense / Q000494:pharmacology
D000890:Anti-Infective Agents; D020135:Peptide Nucleic Acids; D016372:RNA, Antisense