title: Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster.
abstract: Anti-NMDA-receptor encephalitis was initially described as a paraneoplastic disorder in young women with ovarian teratoma. We report on a 3-year-old boy who developed anti-NMDA-receptor encephalitis one month after a respiratory infection. Moreover, array-comparative genomic hybridization in this patient revealed an inherited microdeletion in chromosomeband 6p21.32, including the HLA-DPB1 and HLA-DPB2 genes. The clinical relevance of this microdeletion is discussed.
authors.affiliation: Department of Paediatric Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. helene.verhelst@ugent.be
authors.forename: Helene
authors.initials: H
authors.lastname: Verhelst
authors.forename: Patrick
authors.initials: P
authors.lastname: Verloo
authors.forename: Karlien
authors.initials: K
authors.lastname: Dhondt
authors.forename: Boel
authors.initials: B
authors.lastname: De Paepe
authors.forename: Björn
authors.initials: B
authors.lastname: Menten
authors.forename: Josep
authors.initials: J
authors.lastname: Dalmau
authors.forename: Rudy
authors.initials: R
authors.lastname: Van Coster
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis*; D002675:Child, Preschool; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004660:Encephalitis / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D006681:HLA-D Antigens; D016194:Receptors, N-Methyl-D-Aspartate