title: Improvement of mechanical properties and biocompatibility of forsterite bioceramic addressed to bone tissue engineering materials.
abstract: This work deals with the fabrication and characterization of nanostructured forsterite bulk. This material may have better biocompatibility and mechanical properties than coarse grain forsterite for the development of bone tissue engineering materials. Nanostructured forsterite bulks were prepared by two step sintering of sol-gel derived forsterite nanopowder. Their sinterability and mechanical properties were then studied. Biocompatibility of the nanostructured forsterite bulk was also evaluated by cell attachment and proliferation experiments. In addition, the effects of ionic products from forsterite nanopowder dissolution on osteoblasts were studied. Results show that dense nanostructured forsterite bulk was prepared with hardness and fracture toughness of about 1102 Hv and 4.3 MPa m(1/2), respectively. Nanostructured forsterite was biocompatible and the MTT test confirmed that the products from forsterite nanopowder dissolution significantly promoted osteoblast proliferation within a certain concentration range. In addition, cells attached to and spread on the surface of nanostructured forsterite bulks. Mechanical properties of the nanostructured forsterite were much higher than that of hydroxyapatite. It was concluded that nanostructured forsterite is a bioactive ceramic with good biocompatibility that can be used as a bone tissue engineering material.
authors.affiliation: Biomaterials Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran. kharaziha.ma@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Kharaziha
authors.forename: M H
authors.initials: MH
authors.lastname: Fathi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D055595:Mechanical Phenomena; D036103:Nanotechnology / Q000379:methods*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010316:Particle Size; D017655:Silicon Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D023822:Tissue Engineering
chemical_list: D020099:Coated Materials, Biocompatible; D017655:Silicon Compounds; C503823:forsterite