Noncovalent encapsulation stabilities in supramolecular nanoassemblies.
Exchange dynamics of lipophilic guest molecules, encapsulated in supramolecular nanoassemblies in aqueous solutions, have implications in evaluating the stability of drug delivery vehicles. This is because exchange dynamics is related to the propensity of a nanocarrier to be leaky. We describe a fluorescence resonance energy transfer (FRET) based method to evaluate guest exchange dynamics in the aqueous phase. We have utilized this method to analyze the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.
Jiwpanich
Siriporn
S
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Ryu
Ja-Hyoung
JH
Bickerton
Sean
S
Thayumanavan
S
S
D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D031541:Fluorescence Resonance Energy Transfer; D005782:Gels / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D012995:Solubility; D013816:Thermodynamics
D004337:Drug Carriers; D005782:Gels; D046911:Macromolecular Substances