The use of platelet-rich plasma combined with demineralized freeze-dried bone allograft in the treatment of periodontal endosseous defects: a report of two clinical cases.
BACKGROUND
On the basis of systematic reviews and randomized controlled trials, the authors provide reports of two cases in which platelet-rich plasma (PRP) combined with demineralized freeze-dried bone allograft (DFDBA) was used to treat periodontal endosseous defects.


METHODS
Clinicians treated two circumferential endosseous defects with a probing pocket depth of 5 and 8 millimeters, respectively (case 1), and a combined 1-2-3-wall endosseous defect with a probing pocket depth of 6 mm (case 2) by using the combination of PRP and DFDBA. At six months, complete periodontal pocket resolution occurred in all defects, and clinical attachment level and radiographic defect fill in all defects exhibited significant improvement compared with presurgical values.


CONCLUSIONS
The combination of PRP and DFDBA may be clinically and radiographically efficacious in the treatment of periodontal endosseous defects.
Markou
Nikolaos
N
Periodontal Department, 401 Athens Military Hospital, Athens, Greece.
Pepelassi
Eudoxie
E
Kotsovilis
Sotirios
S
Vrotsos
Ioannis
I
Vavouraki
Helen
H
Stamatakis
Harry Charalabos
HC
D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D018775:Bone Demineralization Technique; D016025:Bone Transplantation / Q000379:methods*; D055113:Chronic Periodontitis / Q000601:surgery; D003646:Debridement; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D053657:Platelet-Rich Plasma; D016300:Radiography, Bitewing; D016745:Root Planing; D013524:Surgical Flaps; D014021:Tissue Preservation / Q000379:methods; D016896:Treatment Outcome