title: Two HLA class I genes independently associated with multiple sclerosis.
abstract: OBJECTIVE
  The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation.
  
  
  METHODS
  1529 MS patients and 1814 controls from Sweden and Norway were genotyped for HLA-DRB1, HLA-A, and HLA-C. Simultaneous analysis of all alleles while adjusting for confounding was achieved using logistic regression.
  
  
  RESULTS
  We observed independent effects of all three genes. We confirm the HLA-A*02 (OR=0.73, p=9.2 x 10(-4)) association and report a novel effect of HLA-C*08 (OR=1.85, p=0.0093).
  
  
  CONCLUSIONS
  The HLA class I region contains two factors modulating MS risk, characterized by independent associations with HLA-A and HLA-C.
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, CMM L8:00, SE-17176 Stockholm, Sweden. jenny.link@ki.se
authors.forename: Jenny
authors.initials: J
authors.lastname: Link
authors.forename: Aslaug R
authors.initials: AR
authors.lastname: Lorentzen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Kockum
authors.forename: Kristina
authors.initials: K
authors.lastname: Duvefelt
authors.forename: Benedicte A
authors.initials: BA
authors.lastname: Lie
authors.forename: Elisabeth G
authors.initials: EG
authors.lastname: Celius
authors.forename: Hanne F
authors.initials: HF
authors.lastname: Harbo
authors.forename: Jan
authors.initials: J
authors.lastname: Hillert
authors.forename: Boel
authors.initials: B
authors.lastname: Brynedal
mesh_terms: D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D015789:HLA-A2 Antigen / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D009664:Norway; D012307:Risk Factors; D013548:Sweden
chemical_list: D015789:HLA-A2 Antigen; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains