What role does mitochondrial stress play in neurodegenerative diseases?
The essential need for mitochondrial function has been extensively shown to relate to neuronal health. Neurodegeneration and neurodegeneration-related diseases have been associated with multiple mitochondrial dysfunctions. This review highlights key findings related to commonly studied mitochondrial dysfunctions: imbalance of mitochondrial dynamics, mutations in the mitochondrial genome, excessive reactive oxygen species, and misfolded protein associations/interactions with the mitochondria. Future research in mitochondrial function will help elucidate complex neurodegenerative events while impacting both individual and societal health.
Pickrell
Alicia Mae
AM
Moraes
Carlos Torres
CT
D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013312:Stress, Physiological
D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species