[Estimation of in vitro Monclavit-1 virucide activity against influenza virus A (H5N1)].
The virucide activity of Monclavit-1 against the influenza virus A/Chicken/Kurgan/2/Russia/05 (H5N1) was investigated in the MDCK cell culture. It was shown that at a temperature of 14.0 +/- 1.0 degrees C Monclavit-1 in a 20-fold dilution within an hour inactivated the cytopathic activity of the virus and the specific hemagglutinin generation by 100 and 87.5% respectively. In a 40-fold dilution it inactivated at the average by 50% both the cytopathic activity and the specific hemagglutinin generation. In an 80-fold dilution it inactivated the cytopathic activity at the average by 20%. In a 160-fold dilution it did not inactivate the pathogen. At a temperature of 25.0 +/- 1.0 degrees C Monclavit-1 inactivated the influenza virus A/Chicken/Kurgan/2/Russia/05 (H5N1) by 90.0% only in the highest concentration.
Loginova
S Ia
SIa
Borisevich
S V
SV
Borisevich
G V
GV
Bondarev
V P
VP
Variukhin
A V
AV
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D004285:Dogs; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D009757:Nylons / Q000494:pharmacology*; D011145:Polyvinyls / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D000998:Antiviral Agents; D009757:Nylons; D011145:Polyvinyls; C551698:poly-N-vinylamide cyclosulfoiodide