Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis.
OBJECTIVE
The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU).


METHODS
A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic AAU. The control group included 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases. The level of NGAL was determined with a commercially available ELISA kit.


RESULTS
The concentration of NGAL in aqueous humor was markedly higher in patients with idiopathic AAU than in control subjects (Mann-Whitney U test, p<0.001). The level of NGAL was 139,197.38+/-183,426.36 (mean+/-SD) pg/ml in eyes with AAU and 3,169.96+/-1,595.78 pg/ml in the eyes of the control group.


CONCLUSIONS
The aqueous humor NGAL level is increased in eyes with idiopathic AAU. These results imply that NGAL is associated with the regulation of inflammation in patients with AAU and could be used as a biomarker of ocular inflammation and immunomodulatory treatment response.
Salom
David
D
Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain. david.salom@yahoo.com
Sanz-Marco
Empar
E
Mullor
Jose L
JL
Lopez-Prats
Maria Jesus
MJ
Garcia-Delpech
Salvador
S
Udaondo
Patricia
P
Millan
Jose Maria
JM
Arevalo
J Fernando
JF
Diaz-Llopis
Manuel
M
D000208:Acute Disease; D000209:Acute-Phase Proteins / Q000378:metabolism*; D001082:Aqueous Humor / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D014606:Uveitis, Anterior / Q000378:metabolism*
D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins