Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity.
New oxathiazinane dioxides have been derived from D- and L-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC(50) approximately 10 microM.
Borcard
Françoise
F
Laboratory of Glycochemistry and Asymmetric Synthesis, Swiss Institute of Technology (EPFL), Lausanne, Switzerland.
Baud
Matthias
M
Bello
Claudia
C
Dal Bello
Giovanna
G
Grossi
Francesco
F
Pronzato
Paolo
P
Cea
Michele
M
Nencioni
Alessio
A
Vogel
Pierre
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D013843:Thiazines