Magnetic resonance metabolomics of intact tissue: a biotechnological tool in cancer diagnostics and treatment evaluation.
Personalized medicine is increasingly important in cancer treatment for its role in staging and its potential to improve stratification of patients. Different types of molecules, genes, proteins, and metabolites are being extensively explored as potential biomarkers. This review discusses the major findings and potential of tissue metabolites determined by high-resolution magic angle spinning magnetic resonance spectroscopy for cancer detection, characterization, and treatment monitoring.
Bathen
Tone F
TF
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. tone.f.bathen@ntnu.no
Sitter
Beathe
B
Sjøbakk
Torill E
TE
Tessem
May-Britt
MB
Gribbestad
Ingrid S
IS
D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055432:Metabolomics / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*