[Magnetic resonance spectroscopy (HMRS) in migraine].
BACKGROUND
There are 4 million people suffering from migraine in Poland, which account; for 10% of national population. Pathomechanism of migraine is not fully understood. In the recent years multiple studies in migraine patients revealed occurrence of metabolic disorders in nervous system tissue.


METHODS
In 30 subjects with migraine diagnosis magnetic resonance spectroscopy examination was performed. Relative concentration ratio (WSS) of metabolites level to creatinine (Cr) level was measured. The obtained values were compared to findings in control groups.


RESULTS
Linear correlation between increase in both WSS Lac/Cr value in left temporal lobe and WSS ml/Cr value in right frontal lobe and a number of migraine attacks per year in migraine patients was observed. It also turned out that WSS ml/Cr vox3 value depends on a total number of migraine attacks in life. A lactic acid level in left temporal lobe normalizes along with the elongation of interattack interval. There is a statistically significant difference of WSS ml/Cr value measured in left temporal lobe and right frontal lobe between migraine patients and control group. There is a statistically significant difference of WSS Cho/Cr value measured in left temporal lobe and right frontal lobe between migraine subjects and control groups.
Trabka-Janik
Elzbieta
E
Katedra i Klinika Neurologii, Uniwersytet Jagielloński Collegium Medicum.
Kułaga
Agnieszka
A
Urbanik
Andrzej
A
Szczudlik
Andrzej
A
Grzybek
Magdalena
M
D000328:Adult; D002794:Choline / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D019344:Lactic Acid; D003404:Creatinine; D002794:Choline