Quadrupolar-coupling-specific binomial pulse sequences for in vivo 23Na NMR and MRI.
Aimed at selective detection of (23)Na with specific quadrupolar couplings for in vitro NMR and MRI, we present a series of quadrupolar binomial pulse sequences offering high specificity with respect to the quadrupolar couplings of the excited species. It is demonstrated that pulse sequences with an increasing number of elements, e.g., 11, 121, 1331, 14641, and 15101051, with the units representing flip angles smaller than the 90 degrees pulses typically encountered in binomial spin-1/2 solvent suppression experiments, and different phase combinations may provide a high degree of flexibility with respect to quadrupolar coupling selectivity and robustness towards rf inhomogeneity. This may facilitate efficient separation of, for example, intra and extracellular (23)Na in tissues with efficient control of the excitation (or suppression) of central as well as satellite transitions through on- and off-resonance irradiation. The pulse sequences are described in terms of their analogy to binomial liquid-state NMR solvent suppression experiments and demonstrated numerically and experimentally through NMR and MRI experiments on a 7 T horizontal small-bore animal magnet system.
Laustsen
Christoffer
C
MR Research Center, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Ringgaard
Steffen
S
Pedersen
Michael
M
Nielsen
Niels Chr
NC
D000465:Algorithms; D000818:Animals; D016477:Artifacts; D001435:Bacteriophages / Q000737:chemistry; D004574:Electromagnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012964:Sodium / Q000737:chemistry* / Q000378:metabolism; D012975:Sodium Isotopes; D012997:Solvents
D012975:Sodium Isotopes; D012997:Solvents; D012964:Sodium