[Influence of fat diet in glicidic metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene].
BACKGROUND
The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA).


OBJECTIVE
Evaluate the influence of dietary fat in glicidic metabolism in morbidly obese women with Pro12Pro genotype in the gene PPARgamma2.


METHODS
Were selected 25 women with genotype Pro12Pro. The fat intake was estimated by food records, being used for the division of groups, GA (until 30% of the total energy expenditure (TEE)) and GB (greater than 30% of the TEE). Biochemical and anthropometric evaluations were conducted in fasting, following the test meal high in n-6 PUFA and postprandial biochemical evaluations. IR and insulin sensitivity (IS) were assessed by HOMA-IR (Homeostasis Model Assessment) and QUICKI (Quantitative Insulin Sensitivity Check Index), respectively.


CONCLUSIONS
GA presented normal HOMAIR and QUICKI. GB presented higher body mass index (BMI), HOMA-IR, saturated fatty acids (SFA) and monounsaturated (MUFA) intake higher, compared with GA (p < 0.05). In GA, the MUFA intake was negatively correlated with HOMA-IR, fasting glucose and insulin, and positively with QUICKI. The fat and SFA intake contributed to the increase in body mass and IR. However, MUFA intake may have reduced the impact of high fat diet in glicidic metabolism. It is suggested that obese women with Pro12Pro genotype in the PPARgamma2 gene avoid high fat and SFA diets, prioritizing MUFA for controlling obesity and improving the IS.
Chaia Kaippert
V
V
Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Brasil.
Lopes Rosado
E
E
Rosa
G
G
Morais Oliveira
E M
EM
Kimi Uehara
S
S
Lima D'Andrea
C
C
Nogueira
J
J
Fofano do Lago
M
M
D000328:Adult; D001786:Blood Glucose / Q000235:genetics* / Q000378:metabolism*; D004041:Dietary Fats; D005260:Female; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*; D047495:PPAR gamma / Q000235:genetics*
D001786:Blood Glucose; D004041:Dietary Fats; D047495:PPAR gamma