C-type natriuretic-derived peptides as biomarkers in human disease.
The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular fluid volume. Atrial natriuretic peptide and B-type natriuretic peptide have gained considerable diagnostic interest as biomarkers in cardiovascular disease. By contrast, C-type natriuretic peptide has not yet been ascribed a role in human diagnostics. This perspective aims at recapitulating the present biochemical and clinical issues concerning C-type natriuretic peptide measurement in plasma as a potential biomarker.
Lippert
Solvej
S
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Goetze
Jens Peter
JP
D000595:Amino Acid Sequence; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008969:Molecular Sequence Data; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D011379:Prognosis; D017386:Sequence Homology, Amino Acid
D015415:Biomarkers; D020098:Natriuretic Peptide, C-Type