Removal of oseltamivir (Tamiflu) and other selected pharmaceuticals from wastewater using a granular bioplastic formulation entrapping propagules of Phanerochaete chrysosporium.
The capacity of the ligninolytic fungus Phanerochaete chrysosporium to degrade a wide variety of environmentally persistent xenobiotics has been largely reported in the literature. Beside other factors, one barrier to a wider use of this bioremediation fungus is the availability of effective formulations that ensure easy preparation, handling and application. In this series of laboratory experiments, we evaluated the efficiency of a granular bioplastic formulation entrapping propagules of P. chrysosporium for removal of four selected pharmaceuticals from wastewater samples. Addition of inoculated granules to samples of the wastewater treatment plant of Bologna significantly increased the removal of the antiviral drug oseltamivir (Tamiflu), and the antibiotics, erythromycin, sulfamethoxazol, and ciprofloxacin. Similar effects were also observed in effluent water. Oseltamivir was the most persistent of the four active substances. After 30d of incubation, approximately two times more oseltamivir was removed in bioremediated wastewater than controls. The highest removal efficiency of the bioplastic formulation was observed with the antibiotic ciprofloxacin. Microbiological DNA-based analysis showed that the bioplastic matrix supported the growth of P. chrysosporium, thus facilitating its adaptation to unusual environment such as wastewater.
Accinelli
Cesare
C
Department of Agro-Environmental Science and Technology, University of Bologna, Viale Fanin 44, Bologna, Italy. cesare.accinelli@unibo.it
Saccà
Maria Ludovica
ML
Batisson
Isabelle
I
Fick
Jerker
J
Mencarelli
Mariangela
M
Grabic
Roman
R
D000890:Anti-Infective Agents / Q000032:analysis / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002939:Ciprofloxacin / Q000032:analysis / Q000378:metabolism; D004917:Erythromycin / Q000032:analysis / Q000378:metabolism; D053139:Oseltamivir / Q000032:analysis / Q000378:metabolism*; D020075:Phanerochaete / Q000378:metabolism*; D011108:Polymers; D013420:Sulfamethoxazole / Q000032:analysis / Q000378:metabolism; D014865:Waste Disposal, Fluid / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism*; D015262:Xenobiotics / Q000032:analysis / Q000378:metabolism
D000890:Anti-Infective Agents; C068018:Bioplastique; D011108:Polymers; D014874:Water Pollutants, Chemical; D015262:Xenobiotics; D053139:Oseltamivir; D002939:Ciprofloxacin; D004917:Erythromycin; D013420:Sulfamethoxazole