title: Cartilage repair: A review of Stanmore experience in the treatment of osteochondral defects in the knee with various surgical techniques.
abstract: Articular cartilage damage in the young adult knee, if left untreated, it may proceed to degenerative osteoarthritis and is a serious cause of disability and loss of function. Surgical cartilage repair of an osteochondral defect can give the patient significant relief from symptoms and preserve the functional life of the joint. Several techniques including bone marrow stimulation, cartilage tissue based therapy, cartilage cell seeded therapies and osteotomies have been described in the literature with varying results. Established techniques rely mainly on the formation of fibro-cartilage, which has been shown to degenerate over time due to shear forces. The implantation of autologous cultured chondrocytes into an osteochondral defect, may replace damaged cartilage with hyaline or hyaline-like cartilage. This clinical review assesses current surgical techniques and makes recommendations on the most appropriate method of cartilage repair when managing symptomatic osteochondral defects of the knee. We also discuss the experience with the technique of autologous chondrocyte implantation at our institution over the past 11 years.
authors.affiliation: Joint Reconstruction and Cartilage Transplantation Unit, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Vijayan
authors.forename: G
authors.initials: G
authors.lastname: Bentley
authors.forename: Twr
authors.initials: T
authors.lastname: Briggs
authors.forename: Ja
authors.initials: J
authors.lastname: Skinner
authors.forename: Rwj
authors.initials: R
authors.lastname: Carrington
authors.forename: R
authors.initials: R
authors.lastname: Pollock
authors.forename: Am
authors.initials: A
authors.lastname: Flanagan