Chiral analysis of pharmaceuticals by capillary electrophoresis using antibiotics as chiral selectors.
The review summarizes the use of the chiral capillary electrophoresis (CE) with different class of antibiotics as chiral selectors in the pharmaceutical field. Basic factors influencing the enantioseparation are shortly discussed. Non-aqueous capillary electrophoresis is also included as well as the coupling of CE to MS. The selection of a chiral selector according the ionic state and structure of the analyte is described. Summary of pharmaceutical applications of chiral CE is given.
Prokhorova
Aleksandra F
AF
Lomonosov Moscow State University, Chemistry Department, Analytical Chemistry Division, Leninskie Gory, d.1, str.3, 119991 Moscow, Russian Federation. alexapro@gmail.com
Shapovalova
Elena N
EN
Shpigun
Oleg A
OA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D004364:Pharmaceutical Preparations