Using a type 1 collagen-based system to understand cell-scaffold interactions and to deliver chimeric collagen-binding growth factors for vascular tissue engineering.
Vascular tissue engineering should provide more biocompatible and functional conduits than synthetic vascular grafts. Understanding cell-scaffold interactions and developing an efficient delivery system for growth factors and other biomolecules to control the signaling between the cells and the scaffold are fundamental issues in a wide range of tissue engineering research fields. Type 1 collagen is a natural scaffold extensively used in vascular tissue engineering and is a widely used vehicle in biomolecule delivery. In this article, we will discuss type 1 collagen as a vascular tissue engineering scaffold, describe strategies for elucidating the interaction between cells and type 1 collagen scaffolds using various imaging techniques, and summarize our work on the development of a chimeric collagen-binding growth factor-based local delivery system.
Pang
Yonggang
Y
Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
Greisler
Howard P
HP
D000818:Animals; D001807:Blood Vessel Prosthesis; D024042:Collagen Type I / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000493:pharmacokinetics*; D011485:Protein Binding; D011993:Recombinant Fusion Proteins; D054457:Tissue Scaffolds
D024042:Collagen Type I; D036341:Intercellular Signaling Peptides and Proteins; D011993:Recombinant Fusion Proteins