title: Dichoptic suppression of mfVEP amplitude: effect of retinal eccentricity and simulated unilateral visual impairment.
abstract: OBJECTIVE
  To investigate the effect of retinal eccentricity on the phenomenon of dichoptic suppression of the mfVEP amplitude and to examine the relationship between the degree of simulated unilateral visual impairment and the possible release of dichoptic suppression in the contralateral eye.
  
  
  METHODS
  Eight subjects with corrected visual acuity (VAc) >6/6 and stereoacuity >60 sec arc underwent monocular and dichoptic pattern-pulse mfVEP. Dichoptic stimulation was repeated with refractively induced blur of one eye with +4-D and +6-D lenses above distance correction.
  
  
  RESULTS
  Dichoptic recording resulted in significant reduction of averaged mfVEP amplitude (19.8% ± 4.9%, paired t-test, P = 0.00003). The magnitude of suppression, while statistically significant at all eccentricities, was significantly larger in the central part of the visual field and diminished toward the periphery. Refractive blur, used to simulate visual impairment produced variable degrees of amplitude reduction in the blurred eye and resulted in amplitude increases in the contralateral eye. There was a highly significant correlation between the magnitude of amplitude reduction in the blurred eye and increase in amplitude (i.e., release of dichoptic suppression) in the contralateral eye (r = 0.91, P < 0.0001).
  
  
  CONCLUSIONS
  The study demonstrated that dichoptic stimulation results in eccentricity-dependent suppression of mfVEP amplitude. Factors affecting visual performance of one eye (monocular blur) promote the release of dichoptic suppression in the fellow (unaffected) eye. This phenomenon leads to an increase in intereye asymmetry and therefore may improve early detection of ocular diseases, especially monocular pathologic processes.
authors.affiliation: Australian School of Advanced Medicine (ASAM), Macquarie University, Sydney, New South Wales, Australia. john.leaney@students.mq.edu.au
authors.forename: John
authors.initials: J
authors.lastname: Leaney
authors.forename: Alexander
authors.initials: A
authors.lastname: Klistorner
authors.forename: Hemamalini
authors.initials: H
authors.lastname: Arvind
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Graham
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012160:Retina / Q000503:physiopathology*; D014786:Vision Disorders / Q000503:physiopathology*; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity