title: The ECITTS integrated toxicity testing scheme: The application of in vitro test systems to the hazard assessment of chemicals.
abstract: A multicentre project has been designed, with the purpose of developing the concept of integrated in vitro testing. The aim is to use non-animal methods to assess the toxicological properties of chemicals, and to improve this assessment through the use of knowledge of mechanisms of toxic action. A number of tests or test batteries were selected within eight areas: basal cytotoxicity, irritancy, developmental toxicology, hepatotoxicity, nephrotoxicity, immunotoxicity, neurotoxicity and biokinetics. For each area, a number of calibration chemicals were selected. In an initial pilot study, the neurotoxic properties of five chemicals will be studied in combination with a biokinetic analysis, in which blood and brain concentrations will be predicted from biokinetic modelling.
authors.affiliation: ERGATT, Secretariat: c/o Research Institute of Toxicology, Utrecht University, PO Box 80.176, 3508 TD Utrecht, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Blaauboer
authors.forename: M
authors.initials: M
authors.lastname: Balls
authors.forename: V
authors.initials: V
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Bolcsfoldi
authors.forename: A
authors.initials: A
authors.lastname: Guillouzo
authors.forename: G A
authors.initials: GA
authors.lastname: Moore
authors.forename: L
authors.initials: L
authors.lastname: Odland
authors.forename: C A
authors.initials: CA
authors.lastname: Reinhardt
authors.forename: H
authors.initials: H
authors.lastname: Spielmann
authors.forename: E
authors.initials: E
authors.lastname: Walum