title: [Surgical treatment of thoracic and thoracolumbar spinal tuberculosis].
abstract: OBJECTIVE
  To explore the surgical measurements and principles in the treatment of thoracic and thoracolumbar spinal tuberculosis.
  
  
  METHODS
  From 2001 to 2008, 232 cases of thoracic or thoracolumbar spinal tuberculosis were treated by operations in the study, including 148 males and 84 females with an average age of 37.8 years ranging from 20 to 76 years. Preoperative assessment displayed as follow: Cobb angles of kyphosis < 30 degrees in 65 cases, 30 degrees to 60 degrees in 147 cases, > 60 degrees in 20 cases; Frankel B grade in 13 cases, C in 12 cases, D in 41 cases, E in 166 cases. Among them, 48 cases were performed with one-stage transpedicular screw system and anterolateral debridement by single incision, 184 cases with one-stage anterior approach (debridement, fusion, and plate-screw fixation) routinely. The tissues and liquor puris debrided from focus were sent for pathological examination, Bacillus tuberculosis detection and culture, and drug sensitivity test. The patients were given anti-tuberculosis therapy according the results of drug sensitivity test for 1 to 1.5 years. The followed-up included relapse rate, fusion of the bone graft, the status of neurological restoring, kyphosis correction etc.
  
  
  RESULTS
  All 232 cases recovered from perioperation and 230 cases got primary wound healing, only 2 cases performed with single incision one-stage posterior instrumentation and anterolateral debridement got complications of wound healing problems and the sinus formation,which delayed healed by changing dressings. The complications included intercostals neuralgia in 135 cases and pneumothorax or hydrothorax in 13 cases, which needed not special handling. All the patients in this series got the followed-up ranging from 1.0 to 4.5 years (means 2.6 years). No recurrence within followed-up period and bone union was found in all cases. All 66 cases with the neurological deficits recovered partially or totally. Kyphosis correction were achieved by 27.5 degrees on average postoperatively and showed a mild loss of 4.2 degrees on average during followed-up period. All cases were confirmed with Bacillus tuberculosis infection by pathology. Bacillus tuberculosis was detected and culture successfully in 107 cases (46.1%), 40 strains (37.4%) were drug resistant and in which 8 strains (7.5%) were multi-drug resistant.
  
  
  CONCLUSIONS
  For the treatment of thoracic and thoracolumbar spinal tuberculosis, the best treatment include directional chemotherapy, one-stage anterior approach with thorough debridement, auto-rib or Ti-mesh fusion, and plate-screw fixation.
authors.affiliation: Department of Orthopaedics, 309th Hospital of PLA, Beijing 100091, China.
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Yu
authors.forename: Yuan-Zheng
authors.initials: YZ
authors.lastname: Ma
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000382:microbiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D013904:Thoracic Vertebrae / Q000382:microbiology / Q000601:surgery*; D014399:Tuberculosis, Spinal / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents