title: Prospects of molecular photoacoustic imaging at 1064 nm wavelength.
abstract: An analysis of the photoacoustic (PA) signal from murine tissue in vivo revealed several benefits of contrast-enhanced PA imaging at a wavelength of 1064nm. Of all the wavelengths tested in a range from 710 to 1064nm, the background PA signal from tissue in vivo was lowest and more homogeneous at 1064nm. For blood-laden tissue, the background PA signal was up to 70% less at 1064nm. Furthermore, when plasmonic nanoparticles, such as silver nanoplates, were introduced in vivo as contrast agents, the contrast in PA images at 1064nm increased 38% compared to 750nm. Therefore, contrast-enhanced PA imaging at 1064nm is advantageous because of the low and homogeneous signal from native tissue, enabling high contrast in PA imaging when exogenous, molecularly targeted agents are employed.
authors.affiliation: Biomedical Engineering Department, The University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Homan
authors.forename: Seungsoo
authors.initials: S
authors.lastname: Kim
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Srivalleesha
authors.initials: S
authors.lastname: Mallidi
authors.forename: Stanislav
authors.initials: S
authors.lastname: Emelianov
mesh_terms: D000162:Acoustics; D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007834:Lasers; D008027:Light; D051379:Mice; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D009368:Neoplasm Transplantation; D055095:Optics and Photonics; D012834:Silver / Q000737:chemistry
chemical_list: D003287:Contrast Media; D012834:Silver