[Possible daptomycin-induced organizing pneumonia].
We report a possible and rare case of drug-induced organizing pneumonia in a patient receiving daptomycin. A 75-year-old man with acute infective aorta valve endocarditis due to Enterococcus faecalis developed organizing pneumonia following treatment with intravenous daptomycin and ceftriaxone. The patient could have acquired an infectious agent which was resistant to ceftriaxone, such as Legionella, and he was thus treated with ciprofloxacin and rifampicin. However, no antigen was found in the urine, and the patient's symptoms subsided after daptomycin was discontinued.
Søndergaard
Turid Snekloth
TS
Klinisk Mikrobiologisk Afdeling, Regionshospitalet Herning, 7400 Herning, Denmark. turids@mail.tele.dk
Schumacher
Helga
H
Norup
Kirsten
K
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002443:Ceftriaxone / Q000009:adverse effects; D017576:Daptomycin / Q000009:adverse effects*; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D013293:Enterococcus faecalis; D004802:Eosinophilia / Q000139:chemically induced; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000139:chemically induced* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D017576:Daptomycin