title: Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients.
abstract: Previous electrophysiological studies of the basal ganglia in Parkinson's disease (PD) patients have utilized linear analyses in time-or-frequency-domains to characterize neuronal discharge patterns. However, these measures do not fully describe the non-linear features of discharge rates and oscillatory activities of basal ganglia neurons. In this original research, we investigate whether non-linear temporal organizations exist in the inter-spike interval series of neurons recorded in the globus pallidus or the subthalamic nucleus in PD patients undergoing surgery for the implantation of deep brain stimulating electrodes. Our data indicate that in approximately 80% of globus pallidus and subthalamic neurons, the raw inter-spike interval sequences have lower entropy values than those observed after shuffling of the original series. This is the first report establishing non-linear temporal organization as a common feature of neuronal discharge in the basal ganglia of PD patients.
authors.affiliation: Department of Neurosurgery, S & W Hospital, Temple TX.
authors.forename: Jongil
authors.initials: J
authors.lastname: Lim
authors.forename: Manjit K
authors.initials: MK
authors.lastname: Sanghera
authors.forename: Olivier
authors.initials: O
authors.lastname: Darbin
authors.forename: R Malcolm
authors.initials: RM
authors.lastname: Stewart
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
authors.forename: Richard
authors.initials: R
authors.lastname: Simpson