Graphene-based SELDI probe with ultrahigh extraction and sensitivity for DNA oligomer.
We demonstrate that graphene can be used as an ultrahigh efficiency preconcentration and detection platform for ssDNA. DNA-adsorbed graphene can be used directly for Surface Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometry (SELDI-TOF-MS). The rapid enrichment of biomolecules and direct, label-free detection are potentially useful for analysis in proteomics and genomics.
Tang
Lena Ai Ling
LA
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.
Wang
Junzhong
J
Loh
Kian Ping
KP
D002244:Carbon / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification*; D008853:Microscopy; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D002244:Carbon; D004247:DNA