title: Redox atlas of the mouse. Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse.
abstract: BACKGROUND
  Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease conditions, no systematic information on the presence of these proteins is available.
  
  
  METHODS
  Here, we have systematically analyzed the presence of some of the major constituents of the glutaredoxin (Grx)-, peroxiredoxin (Prx)-, and thioredoxin (Trx)-systems, i.e. Grx1, Grx2, Grx3 (TXNL-2/PICOT), Grx5, nucleoredoxin (Nrx), Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, thioredoxin reductase 1 (TrxR1), Trx2, TrxR2, and γ-glutamyl cysteine synthetase (γ-GCS) in various tissues of the mouse using immunohistochemistry.
  
  
  RESULTS
  The identification of the Trx family proteins in the central nervous system, sensory organs, digestive system, lymphatic system, reproductive system, urinary system, respiratory system, endocrine system, skin, heart, and muscle revealed a number of significant differences between these proteins with respect to their distribution in these tissues.
  
  
  CONCLUSIONS
  Our results imply more specific functions and interactions between the proteins of this family than previously assumed.
  
  
  CONCLUSIONS
  Crucial functions of Trx family proteins have been demonstrated in various disease conditions. A detailed overview on their distribution in various tissues will be helpful to fully comprehend their potential role and the interactions of these proteins in the most thoroughly studied model for human diseases-the laboratory mouse. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.
authors.affiliation: Institut für Klinische Zytobiologie und Zytopathologie, Fachbereich Medizin, Philipps Universität, Marburg, Germany.
authors.forename: José Rodrigo
authors.initials: JR
authors.lastname: Godoy
authors.forename: Maria
authors.initials: M
authors.lastname: Funke
authors.forename: Waltraud
authors.initials: W
authors.lastname: Ackermann
authors.forename: Petra
authors.initials: P
authors.lastname: Haunhorst
authors.forename: Sabrina
authors.initials: S
authors.lastname: Oesteritz
authors.forename: Francisco
authors.initials: F
authors.lastname: Capani
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Elsässer
authors.forename: Christopher Horst
authors.initials: CH
authors.lastname: Lillig
mesh_terms: D000818:Animals; D001271:Atlases as Topic; D005260:Female; D054477:Glutaredoxins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction; D054464:Peroxiredoxins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D013879:Thioredoxins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D054477:Glutaredoxins; D013879:Thioredoxins; D054464:Peroxiredoxins