title: Balanced translocation in mother leading to interchange trisomy 21?
abstract: We report an unusual balanced translocation involving chromosomes 4 and 21 in a lady who had Down syndrome in her previous child. The most plausible explanation for this event is the 3:1 segregation of chromosomes at meiosis in her gametes leading to interchange trisomy 21.
authors.affiliation: Genetics Clinic, Department of Pediatrics, Kasturba Medical College, Manipal, India. girishkatta@gmail.com
authors.forename: K M
authors.initials: KM
authors.lastname: Girisha
authors.forename: M
authors.initials: M
authors.lastname: Rajasekhar
authors.forename: P M
authors.initials: PM
authors.lastname: Gopinath
authors.forename: K
authors.initials: K
authors.lastname: Satyamoorthy
mesh_terms: D000328:Adult; D020090:Chromosome Segregation; D002894:Chromosomes, Human, Pair 4; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D014178:Translocation, Genetic / Q000235:genetics*