title: Bone grafting by means of a tunnel dissection: predictable results using stem cells and matrix.
abstract: Bone marrow aspirate has been shown to add stem cells, growth factors, and cytokines to bone graft matrices used in bone augmentation sites. The combination of bone marrow aspirate and resorbable scaffold material has a significant osteogenic capability that exceeds that of autogenous bone grafts. This article describes a subperiosteal tunneling technique for applying such grafts to defective sites. Treatment of 2 patients for whom the technique was used to graft 6 deficient sites is described. Histological results and histomorphometric analysis of bone core samples taken from 4 of the 6 grafting sites are also reported. Analysis of the 4 bone cores taken between 4 and 6 months showed a range of 34% to 45% of new bone.
authors.affiliation: soltandds@aol.com
authors.forename: Muna
authors.initials: M
authors.lastname: Soltan
authors.forename: Dennis
authors.initials: D
authors.lastname: Smiler
authors.forename: Christine
authors.initials: C
authors.lastname: Soltan
authors.forename: Hari S
authors.initials: HS
authors.lastname: Prasad
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rohrer
mesh_terms: D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods; D001672:Biocompatible Materials / Q000627:therapeutic use; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000379:methods*; D001857:Bone Matrix / Q000637:transplantation*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004210:Dissection / Q000379:methods*; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D010521:Periosteum / Q000601:surgery; D013524:Surgical Flaps; D054457:Tissue Scaffolds; D020858:Tissue and Organ Harvesting / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D015921:Dental Implants; C485817:beta-tricalcium phosphate; D017886:Durapatite