title: [A case of localized malignant pleural mesothelioma].
abstract: A 74-year-old man was referred to our hospital for examination of an abnormal chest shadow. A chest computed tomography (CT) scan revealed a 5-cm mass attached to the pleura involving the right upper lobe, and a nodule in the right middle lobe. Transbronchial lung biopsy was performed twice, but no definitive diagnosis was achieved. 18-fluorodeoxyglucose positron emission tomography showed abnormal uptake in the chest lesion. Chemotherapy was initiated for advanced-stage lung cancer, but was not effective. Histopathologic and immunohistochemical examinations after CT-guided needle biopsy revealed malignant mesothelioma. The tumor cells were positive for calretinin and thrombomodulin, and negative for CEA, TTF-1, and SP-A. There was local tumor invasion and metastasis in the lung and brain, without diffuse pleural spread. This is a rare and important case of localized malignant mesothelioma pathologically confirmed by biopsy.
authors.affiliation: Department of Respiratory Medicine, Kyushu Rosai Hospital.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tamura
authors.forename: Minako
authors.initials: M
authors.lastname: Kozaki
authors.forename: Masamizu
authors.initials: M
authors.lastname: Kunimoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Tokuyama
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kawanami
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hamada
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Morooka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D010997:Pleural Neoplasms / Q000473:pathology*; D054363:Solitary Fibrous Tumor, Pleural / Q000473:pathology*