title: Pulmonary manifestations of the idiopathic inflammatory myopathies.
abstract: Pulmonary involvement in myositis includes interstitial lung disease (ILD), respiratory muscle weakness, aspiration, infections, and drug-induced disease. ILD may precede myositis, and results in increased morbidity and mortality rates. Initial evaluation should include pulmonary function tests and high-resolution computed tomography. Nonspecific interstitial pneumonia (NSIP) is the most common histologic pattern on lung biopsy. Treatment usually consists of a combination of steroids and other immunosuppressive agents, and the response depends on the clinical presentation and underlying histology.
authors.affiliation: Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada. meenakalluri@med.ualberta.ca
authors.forename: Meena
authors.initials: M
authors.lastname: Kalluri
authors.forename: Chester V
authors.initials: CV
authors.lastname: Oddis
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D003882:Dermatomyositis / Q000150:complications* / Q000276:immunology; D004417:Dyspnea / Q000209:etiology*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D010995:Pleural Diseases / Q000150:complications / Q000209:etiology; D017285:Polymyositis / Q000150:complications* / Q000276:immunology; D011379:Prognosis
chemical_list: D015415:Biomarkers