Programmable diagnostic devices made from paper and tape.
This paper describes three-dimensional microfluidic paper-based analytical devices (3-D microPADs) that can be programmed (postfabrication) by the user to generate multiple patterns of flow through them. These devices are programmed by pressing single-use 'on' buttons, using a stylus or a ballpoint pen. Pressing a button closes a small space (gap) between two vertically aligned microfluidic channels, and allows fluids to wick from one channel to the other. These devices are simple to fabricate, and are made entirely out of paper and double-sided adhesive tape. Programmable devices expand the capabilities of microPADs and provide a simple method for controlling the movement of fluids in paper-based channels. They are the conceptual equivalent of field-programmable gate arrays (FPGAs) widely used in electronics.
Martinez
Andres W
AW
Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Phillips
Scott T
ST
Nie
Zhihong
Z
Cheng
Chao-Min
CM
Carrilho
Emanuel
E
Wiley
Benjamin J
BJ
Whitesides
George M
GM
D004209:Disposable Equipment; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010209:Paper; D011933:Reagent Kits, Diagnostic
D011933:Reagent Kits, Diagnostic