title: Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors.
abstract: Previously, we reported new methods for ultrasound signal characterization using entropy, H(f); a generalized entropy, the Renyi entropy, I(f)(r); and a limiting form of Renyi entropy suitable for real-time calculation, I(f),(infinity). All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, I(f),(infinity), is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.
authors.forename: Jon N
authors.initials: JN
authors.lastname: Marsh
authors.forename: Kirk D
authors.initials: KD
authors.lastname: Wallace
authors.forename: John E
authors.initials: JE
authors.lastname: McCarthy
authors.forename: Mladen V
authors.initials: MV
authors.lastname: Wickerhauser
authors.forename: Brian N
authors.initials: BN
authors.lastname: Maurizi
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Lanza
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Wickline
authors.forename: Michael S
authors.initials: MS
authors.lastname: Hughes
mesh_terms: D000465:Algorithms; D000818:Animals; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D003287:Contrast Media; D019277:Entropy; D005260:Female; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D014183:Transplantation, Heterologous; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media