Total synthesis of grassypeptolide.
The first total synthesis of grassypeptolide, an anticancer cyclodepsipeptide isolated from marine cyanobacteria, has been achieved in 17 steps and an overall 11.3% yield.
Liu
Hui
H
Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, China 518055.
Liu
Yuqing
Y
Xing
Xiangyou
X
Xu
Zhengshuang
Z
Ye
Tao
T
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000138:chemical synthesis*; D015394:Molecular Structure
D000970:Antineoplastic Agents; D047630:Depsipeptides; C528460:grassypeptolide