title: Armadillo-repeat protein functions: questions for little creatures.
abstract: Armadillo (ARM)-repeat proteins form a large family with diverse and fundamental functions in many eukaryotes. ARM-repeat proteins have largely been characterised in multicellular organisms and much is known about how a subset of these proteins function. The structure of ARM-repeats allows proteins containing them to be functionally very versatile. Are the ARM-repeat proteins in 'little creatures' as multifunctional as their better-studied relatives? The time is now right to start analysing ARM-repeat proteins in these new systems to better understand their cell biology. Here, we review recent advances in understanding the many cellular roles of both well-known and novel ARM-repeat proteins.
authors.affiliation: Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.
authors.forename: Rita
authors.initials: R
authors.lastname: Tewari
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bailes
authors.forename: Karen A
authors.initials: KA
authors.lastname: Bunting
authors.forename: Juliet C
authors.initials: JC
authors.lastname: Coates
mesh_terms: D000818:Animals; D051186:Armadillo Domain Proteins / Q000737:chemistry* / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology
chemical_list: D051186:Armadillo Domain Proteins; D009687:Nuclear Proteins