title: Dietary fatty acids and oxidative stress in the heart mitochondria.
abstract: Our study compared the effects of different oils on oxidative stress in rat heart mitochondria, as well as on plasma parameters used as risk factors for cardiovascular disease. The rats were fed for 16 weeks with coconut, olive, or fish oil diet (saturated, monounsaturated, or polyunsaturated fatty acids, respectively). The cardiac mitochondria from rats fed with coconut oil showed the lowest concentration of oxidized proteins and peroxidized lipids. The fish oil diet leads to the highest oxidative stress in cardiac mitochondria, an effect that could be partly prevented by the antioxidant probucol. Total and LDL cholesterols decreased in plasma of rats fed fish oil, compared to olive and coconut oils fed rats. A diet enriched in saturated fatty acids offers strong advantages for the protection against oxidative stress in heart mitochondria.
authors.affiliation: Laboratoire de Biologie Intégrative, Université du Québec, Rimouski, Québec, Canada.
authors.forename: Hélène
authors.initials: H
authors.lastname: Lemieux
authors.forename: Anne Laure
authors.initials: AL
authors.lastname: Bulteau
authors.forename: Bertrand
authors.initials: B
authors.lastname: Friguet
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
authors.forename: Pierre U
authors.initials: PU
authors.lastname: Blier
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D000074263:Coconut Oil; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D015227:Lipid Peroxidation; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D000069463:Olive Oil; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008078:Cholesterol, LDL; D004041:Dietary Fats; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D002784:Cholesterol; D000074263:Coconut Oil