Design, synthesis and acaricidal activity of novel strobilurin derivatives containing pyrimidine moieties.
BACKGROUND
The intermediate derivatisation method based on bioisosteric replacement led to the discovery of the lead strobilurin compound 5a. To produce new strobilurin analogues with improved activity, a series of substituted pyrimidines were synthesised and bioassayed.


RESULTS
The compounds were identified by (1)H NMR, IR, MS and elemental analysis. The highly active compound 5 g was studied by X-ray diffraction. Preliminary bioassays demonstrated that some of the title compounds exhibited excellent acaricidal activity against Tetranychus cinnabarinus (Boisd.) at 10 mg L(-1). The relationship between structure and acaricidal activity is reported.


CONCLUSIONS
The present work demonstrates that strobilurin derivatives containing pyrimidine moieties can be used as possible lead compounds for developing novel acaricides.
Chai
Bao-Shan
BS
State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry, Shenyang, China.
Liu
Chang-Ling
CL
Li
Hui-Chao
HC
He
Xiao-Min
XM
Luo
Yan-Mei
YM
Huang
Guang
G
Zhang
Hong
H
Chang
Jun-Biao
JB
D056810:Acaricides / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D007854:Lead / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008689:Methacrylates / Q000737:chemistry*; D010571:Pest Control; D011743:Pyrimidines / Q000737:chemistry; D040102:Tetranychidae
D056810:Acaricides; D008689:Methacrylates; D011743:Pyrimidines; D007854:Lead; C030986:pyrimidine