Chromatographic analysis of local anesthetics in biological samples.
This paper reviews gas and liquid chromatographic methods for screening, identification and quantification of local anesthetics and/or their metabolites in biological samples. Basic information about sample preparation, separation, detection, and quantification of each procedure is summarised. The pros and cons of the various procedures are critically discussed.
Baniceru
Mihaela
M
University of Medicine and Pharmacy, Faculty of Pharmacy, Petru Rares, 4, 200349, Craiova, Romania. mihaelabaniceru@yahoo.com
Manda
Costel Valentin
CV
Popescu
Sanda Mihaela
SM
D000779:Anesthetics, Local / Q000032:analysis / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D002623:Chemistry Techniques, Analytical; D002624:Chemistry, Clinical / Q000379:methods; D002849:Chromatography, Gas / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry / Q000379:methods*; D008956:Models, Chemical; D052617:Solid Phase Microextraction
D000779:Anesthetics, Local