Stem cells and DNA damage: persist or perish?
Stem cells repopulate tissues after injury while also renewing themselves, but this makes them vulnerable to genotoxic damage. Mohrin et al. (2010) and Milyavsky et al. (2010) now show that mouse and human hematopoietic stem cells make opposing decisions about whether to die or to persist in response to DNA damage.
Lane
Andrew A
AA
Center for Regenerative Medicine, Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA. aalane@partners.org
Scadden
David T
DT