title: Low plasma adiponectin as a potential biomarker for osteonecrosis of the femoral head.
abstract: OBJECTIVE
  To examine whether plasma adiponectin level is correlated with osteonecrosis of the femoral head (ONFH).
  
  
  METHODS
  Blood adiponectin level in patients with nontraumatic ONFH (n = 120) was compared with a group of healthy subjects (n = 120). Patients with hip osteoarthritis (OA; n = 30) and traumatic ONFH (n = 45) were included as controls. Potential compounding factors, such as plasma low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A1 (apo A1), apolipoprotein B (apo B), total cholesterol (TC), triglycerides (TG), and C-reactive protein (CRP) were also examined.
  
  
  RESULTS
  Patients with nontraumatic ONFH had significantly lower plasma levels of adiponectin than the healthy controls (7.14 ± 3.53 vs 10.93 ± 3.41 μg/ml, respectively; p < 0.001). Adiponectin level was positively correlated with HDL (r = 0.282, p < 0.001) and age (r = 0.145, p = 0.01), yet negatively correlated with body mass index (r = -0.70, p < 0.001), TG (r = -0.55, p<0.001), LDL/HDL ratio (r = -0.173, p = 0.002), and CRP (r = -0.634, p < 0.001). No correlation was seen with LDL (r = -0.017, p = 0.762). A multiple logistic regression analysis revealed that adiponectin level is an independent predictor of the presence of nontraumatic ONFH (p < 0.001, OR 0.676, 95% CI 0.546 to 0.845).
  
  
  CONCLUSIONS
  Low adiponectin level is significantly associated with the presence of nontraumatic ONFH. This biomarker may be useful in assessing the potential presence of nontraumatic ONFH.
authors.affiliation: Division of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shuai
authors.forename: Lin
authors.initials: L
authors.lastname: Shen
authors.forename: Yan P
authors.initials: YP
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Zhe X
authors.initials: ZX
authors.lastname: Shou
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005270:Femur Head / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000097:blood / Q000473:pathology; D010020:Osteonecrosis / Q000097:blood* / Q000473:pathology*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002097:C-Reactive Protein