title: SPRINT: side-chain prediction inference toolbox for multistate protein design.
abstract: SPRINT is a software package that performs computational multistate protein design using state-of-the-art inference on probabilistic graphical models. The input to SPRINT is a list of protein structures, the rotamers modeled for each structure and the pre-calculated rotamer energies. Probabilistic inference is performed using the belief propagation or A* algorithms, and dead-end elimination can be applied as pre-processing. The output can either be a list of amino acid sequences simultaneously compatible with these structures, or probabilistic amino acid profiles compatible with the structures. In addition, higher order (e.g. pairwise) amino acid probabilities can also be predicted. Finally, SPRINT also has a module for protein side-chain prediction and single-state design.
  
  
  BACKGROUND
  The full C++ source code for SPRINT can be freely downloaded from http://www.protonet.cs.huji.ac.il/sprint.
authors.affiliation: School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel. fromer@cs.huji.ac.il
authors.forename: Menachem
authors.initials: M
authors.lastname: Fromer
authors.forename: Chen
authors.initials: C
authors.lastname: Yanover
authors.forename: Amir
authors.initials: A
authors.lastname: Harel
authors.forename: Ori
authors.initials: O
authors.lastname: Shachar
authors.forename: Yair
authors.initials: Y
authors.lastname: Weiss
authors.forename: Michal
authors.initials: M
authors.lastname: Linial
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D015233:Models, Statistical; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D000596:Amino Acids; D011506:Proteins