title: Coordination of Cu2+ ions to C2 symmetric pseudopeptides derived from valine.
abstract: The acid-base and coordination properties of a family of pseudopeptidic ligands with C(2) symmetry derived from valine (4a-e) have been studied using a variety of techniques as a model for metal coordination in peptides and proteins. The Cu(2+) cation has been selected for coordination studies, although, for comparison, some results for Zn(2+) are also presented. Good agreement has been obtained between the results obtained by potentiometric titrations, spectroscopic analysis, and mass spectrometry (ESI) studies. These results highlight the potential for the use of ESI MS for characterizing the nature of the complex species formed. Clearly, the Cu(2+) complexes are much more stable than the Zn(2+) complexes. While the role of the aliphatic spacer seems to be very minor in the case of the Zn(2+) complexes, revealing the ability of this cation to accommodate different coordination environments, this role is critical in the case of Cu(2+). Different complexes with 1:1 or 2:2 Cu(2+):L stoichiometries can be formed according to the length of the spacer and the basicity of the media. This is fully illustrated by the resolution of the X-ray structures of two different Cu(2+) complexes corresponding to the ligands containing a spacer with two methylene groups (ligand 4a, complex 6a [Cu(2)(H(-1)L)(2)](ClO(4))(2) with a 2:2 stoichiometry) and a propylene spacer (4b, complex 5b [CuH(-2)L] x CH(3)CH(2)OH with a 1:1 stoichiometry).
authors.affiliation: Instituto de Ciencia Molecular (ICMOL), Departamento de Química Inorgánica, Universidad de Valencia, 46980 Paterna (Valencia), Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Blasco
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Burguete
authors.forename: M Paz
authors.initials: MP
authors.lastname: Clares
authors.forename: Enrique
authors.initials: E
authors.lastname: García-España
authors.forename: Jorge
authors.initials: J
authors.lastname: Escorihuela
authors.forename: Santiago V
authors.initials: SV
authors.lastname: Luis
mesh_terms: D002413:Cations, Divalent / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011522:Protons; D021241:Spectrometry, Mass, Electrospray Ionization; D014633:Valine / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D002413:Cations, Divalent; D056831:Coordination Complexes; D011522:Protons; D003300:Copper; D014633:Valine; D015032:Zinc