title: Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects.
abstract: OBJECTIVE
  The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGFI concentrations in healthy subjects.
  
  
  METHODS
  Two hundred and forty-one consecutive healthy subjects were included in the present study.
  
  
  METHODS
  Serum IGF-I and 25-(OH) D3 concentrations.
  
  
  RESULTS
  As expected, serum IGF-I concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF-I levels. A positive relationship was identified between serum 25-(OH) D3 and IGF-I concentrations (r=0.33, p<0.0001); the 25-(OH) D3-dependent changes of serum IGF-I concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D3 deficiency (<20 ng/ml) had lower (185 ± 83 μg/l) IGF-I values than those with mild-to absent 25-(OH) D3 deficit (225 ± 83 μg/l, p=0.0004).
  
  
  CONCLUSIONS
  25-(OH) D3 status may contribute to determine serum IGF-I levels in healthy population.
authors.affiliation: Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bogazzi
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: M
authors.initials: M
authors.lastname: Lombardi
authors.forename: L
authors.initials: L
authors.lastname: Tomisti
authors.forename: C
authors.initials: C
authors.lastname: Sardella
authors.forename: L
authors.initials: L
authors.lastname: Manetti
authors.forename: O
authors.initials: O
authors.lastname: Curzio
authors.forename: C
authors.initials: C
authors.lastname: Marcocci
authors.forename: L
authors.initials: L
authors.lastname: Grasso
authors.forename: M
authors.initials: M
authors.lastname: Gasperi
authors.forename: E
authors.initials: E
authors.lastname: Martino
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; D007334:Insulin-Like Growth Factor I