title: Drug delivery system based on chronobiology--A review.
abstract: With the advancement in the field of chronobiology, modern drug delivery approaches have been elevated to a new concept of chronopharmacology i.e. the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawback in the development of such delivery system that matches the circadian rhythm requires the availability of precise technology (pulsatile drug delivery). The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more sub-disciplines expected to coexist in the near future. This review on chronopharmaceutics gives a comprehensive emphasis on potential disease targets, revisits the existing technologies in hand and also addresses the theoretical approaches to emerging discipline such as genetic engineering and target based specific molecules. With the biological prospective approaches in delivering drugs it is well understood that safer and more realistic approaches in the therapy of diseases will be achieved in the days to come.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700032, West Bengal, India.
authors.forename: Asim Sattwa
authors.initials: AS
authors.lastname: Mandal
authors.forename: Nikhil
authors.initials: N
authors.lastname: Biswas
authors.forename: Kazi Masud
authors.initials: KM
authors.lastname: Karim
authors.forename: Arijit
authors.initials: A
authors.lastname: Guha
authors.forename: Sugata
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Mamata
authors.initials: M
authors.lastname: Behera
authors.forename: Ketousetuo
authors.initials: K
authors.lastname: Kuotsu
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004337:Drug Carriers; D055870:Drug Chronotherapy; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D007700:Kinetics; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004304:Dosage Forms; D004337:Drug Carriers