title: Optic neuropathy following radiotherapy for Cushing's disease: case report and literature review.
abstract: Radiation-induced optic neuropathy is a rare adverse effect of radiotherapy applied for the treatment of pituitary adenomas. We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy. Sixteen months after radiotherapy, the patient was presented with declining visual acuity, and radiation-induced optic neuropathy was diagnosed. Despite treatment with glucocorticoids and hyperbaric oxygen, her vision did not improve. The pathophysiology, prevention and treatment of radiation-induced optic neuropathy, including the efficacy of hyperbaric oxygen therapy are reviewed.
authors.affiliation: Department of Surgery, University of Wisconsin, Madison, WI, USA.
authors.forename: Nikiforos
authors.initials: N
authors.lastname: Ballian
authors.forename: Ioannis I
authors.initials: II
authors.lastname: Androulakis
authors.forename: Klio
authors.initials: K
authors.lastname: Chatzistefanou
authors.forename: Christianna
authors.initials: C
authors.lastname: Samara
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tsiveriotis
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Kaltsas
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications / Q000532:radiotherapy*; D000236:Adenoma / Q000150:complications / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006931:Hyperbaric Oxygenation; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D047748:Pituitary ACTH Hypersecretion / Q000209:etiology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D017211:Treatment Failure; D014792:Visual Acuity / Q000528:radiation effects
chemical_list: D005938:Glucocorticoids