Neonatal gastrin-releasing peptide receptor blockade reduces maternal odor preference in rats.
Alterations in attachment behavior might play a role in the dysfunction in social behavior displayed by autistic infants. Here we show that neonatal gastrin-releasing peptide receptor (GRPR) blockade induces a reduction in maternal odor preference, a task involving attachment behavior, in infant rats. These findings provide the first evidence that the GRPR regulates odor preference, supporting the view that the GRPR is involved in attachment and social behaviors.
Garcia
Vanessa A
VA
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, Porto Alegre, RS, Brazil.
Dornelles
Arethuza S
AS
Presti-Torres
Juliana
J
Alcalde
Luisa A
LA
Halmenschlager
Luis Henrique
LH
Schwartsmann
Gilberto
G
Roesler
Rafael
R
Lucion
Aldo B
AB
Schröder
Nadja
N
D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D001839:Bombesin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002755:Choice Behavior / Q000187:drug effects*; D008297:Male; D009812:Odorants; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D018004:Receptors, Bombesin / Q000037:antagonists & inhibitors*
D010446:Peptide Fragments; D018004:Receptors, Bombesin; C071363:bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-; D001839:Bombesin