[Influence of oncological treatment on fertility of women and pregnancy outcome].
Advances in cancer treatment of young patients have resulted in markedly improved survival rates and quality of life. However infertility remains to be one of adverse effects of anticancer therapy. Female patients who receive high-dose abdominal and/or pelvic irradiation or chemotherapy based on alkylating agents are at highest risk of developing ovarian failure. Among women whose fertility was not impaired during oncologic treatment, there is a significantly increased number of premature labors. High-dose irradiation also predisposes to low-birthweight infants. Neither chemotherapy nor radiotherapy increase a risk of congenital malformations.
Markowska
Anna
A
Klinika Perinatologii i Chorób Kobiecych UM im. Karola Marcinkowskiego w Poznaniu. annamarkowska@vp.pl
Pawałowska
Monika
M
Markowska
Janina
J
Litwiniuk
Maria
M
Madry
Radosław
R
Dilmaghani-Tabriz
Darah
D
D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000139:chemically induced / Q000209:etiology*; D009369:Neoplasms / Q000628:therapy*; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000517:prevention & control; D011256:Pregnancy Outcome; D011832:Radiation Injuries / Q000150:complications; D011878:Radiotherapy / Q000009:adverse effects*; D018456:Reproductive Medicine; D027724:Reproductive Techniques, Assisted; D014599:Uterus / Q000187:drug effects / Q000528:radiation effects; D016387:Women's Health
D000970:Antineoplastic Agents