title: Antimicrobial, antioxidant, cytotoxicity and platelet aggregation inhibitory activity of a novel molecule isolated and characterized from mango ginger (Curcuma amada Roxb.) rhizome.
abstract: Mango ginger (Curcuma amada Roxb.) rhizome is used in the manufacture of pickles and other food preparations due to its unique raw mango flavour. The chloroform extract of mango ginger rhizome was subjected to antibacterial activity-guided purification by repeated silica gel column chromatography to obtain a pure compound. The structure of the isolated compound was deduced by analysing UV, IR, LC-MS and 2D-HMQCT NMR spectral data, and named it as amadaldehyde, a novel compound. It exhibited a wide range of antibacterial activity with potential bactericidal activity against several bacteria. The purified compound also exhibited antioxidant activity, cytotoxicity and platelet aggregation inhibitory activities.
authors.affiliation: Department of Biotechnology, Defence Research Laboratory, Tezpur 784 001, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Policegoudra
authors.forename: K
authors.initials: K
authors.lastname: Rehna
authors.forename: L Jaganmohan
authors.initials: LJ
authors.lastname: Rao
authors.forename: S M
authors.initials: SM
authors.lastname: Aradhya
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002460:Cell Line / Q000187:drug effects; D030024:Curcuma / Q000737:chemistry*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000890:Anti-Infective Agents; D000975:Antioxidants; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C555401:amadaldehyde