title: Catalytic enantioselective radical cyclization via regiodivergent epoxide opening.
abstract: A catalytic enantio- and diastereoselective radical cyclization using a regiodivergent epoxide opening (REO) for radical generation is described. It is demonstrated for the first time that the diastereoselectivity of cyclizations of acyclic radicals can be controlled catalytically. Building blocks for important applications in stereoselective synthesis are readily accessed.
authors.affiliation: Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany. andreas.gansaeuer@uni-bonn.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Gansäuer
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Matthias
authors.initials: M
authors.lastname: Otte
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004852:Epoxy Compounds / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D004852:Epoxy Compounds; D005609:Free Radicals