Fine-needle aspiration cytology and (99m)Tc-pertechnetate scintigraphy together in patients with differentiated thyroid carcinoma.
The aim of this study was to evaluate the usefulness of fine-needle aspiration cytology (FNAC) and (99m)Tc-pertechnetate scintigraphy (TS) together in patients with differentiated thyroid carcinoma. Data from a series of 357 patients (284 women and 73 men, median age 43 years, range 19-73) with solitary thyroid nodule and no signs of hyperfunction, who had undergone both FNAC and TS prior to surgery, were retrospectively reviewed. FNAC distinguished 3 groups of TN (benign, follicular neoplasm, cancer), while patients with 'cold' TN were considered at risk of having a thyroid tumor. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were: 95%, 21%, 20%, 95% and 34% for TS; 82%, 99%, 96%, 96% and 96% for FNAC; 98%, 99%, 97%, 98%, and 99% for TS and FNAC together, respectively. In conclusion, patients with 'cold' TN and FNAC suggesting follicular neoplasm should be considered at risk of having cancer.
Lumachi
Franco
F
University of Padua, School of Medicine, Department of Surgical & Gastroenterological Sciences, Via Giustiniani 2, 35128 Padova, Italy. flumachi@unipd.it
Fabbro
Micaela
M
Tregnaghi
Alberto
A
Antunovic
Lidija
L
Bui
Franco
F
Cecchin
Diego
D
Zucchetta
Pietro
P
Fassina
Ambrogio
A
D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013670:Sodium Pertechnetate Tc 99m; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D055815:Young Adult
D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m