Adult Drosophila melanogaster as a model for the study of glucose homeostasis.
Genetic ablation of Drosophila melanogaster insulin-like peptide (DILP) and adipokinetic hormone-producing cells accompanied by cell biological and metabolic measurements have revealed functional conservation in nutrient sensing and the underlying signaling mechanisms between mammal and fruit fly. Despite significant advances gained in understanding the neuroendocrine responses to nutrient changes during developmental larval stages, we discuss here the need for investigating glucose homeostasis in the post-mitotic adult stage as the result of ablation of DILP producing cells (IPCs). Our recent studies demonstrate that while both constitutive and adult-specific partial ablation of IPCs renders those flies hyperglycemic and glucose intolerant, flies with adult-specific IPC ablation remain insulin sensitive. Our results substantiate a role of adult IPCs in modulating aspects of glucose homeostasis and highlight the complexity in DILP action in the adult fly.
Haselton
Aaron T
AT
Department of Biology, State University of New York at New Paltz, New Paltz, NY 12561, USA.
Fridell
Yih-Woei C
YW
D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D056726:Genetic Association Studies; D005818:Genetic Engineering; D005947:Glucose / Q000235:genetics / Q000378:metabolism; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics / Q000378:metabolism; D007301:Insect Hormones / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000235:genetics; D007814:Larva / Q000235:genetics / Q000378:metabolism; D008322:Mammals; D009490:Neurosecretory Systems / Q000502:physiology*; D009747:Nutritional Physiological Phenomena; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
C111892:DIAP2 protein, Drosophila; D029721:Drosophila Proteins; D051034:Inhibitor of Apoptosis Proteins; D007301:Insect Hormones; D007328:Insulin; D009842:Oligopeptides; C044833:adipokinetic hormone; D005947:Glucose; D011761:Pyrrolidonecarboxylic Acid