title: Alteration of cohesin genes in myeloid diseases.
abstract: New genes involved in leukemogenesis, such as ASXL1 and TET2, have been identified recently using genomic analyses of DNA from patient samples. We have studied by array-comparative genomic hybridization (aCGH) a series of 167 samples including myelodysplastic syndromes, chronic myelomonocytic leukemias, and acute myeloid leukemias. We found a deletion of the RAD21 and STAG2 genes, which encode two components of the cohesin complex. We propose that these alterations may compromise the cohesin complex and its regulation of the transcription of genes.
authors.forename: Julien
authors.initials: J
authors.lastname: Rocquain
authors.forename: Véronique
authors.initials: V
authors.lastname: Gelsi-Boyer
authors.forename: José
authors.initials: J
authors.lastname: Adélaïde
authors.forename: Anne
authors.initials: A
authors.lastname: Murati
authors.forename: Nadine
authors.initials: N
authors.lastname: Carbuccia
authors.forename: Norbert
authors.initials: N
authors.lastname: Vey
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
authors.forename: Marie-Joelle
authors.initials: MJ
authors.lastname: Mozziconacci
authors.forename: Max
authors.initials: M
authors.lastname: Chaffanet
mesh_terms: D034961:Antigens, Nuclear / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D049308:Dioxygenases; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010750:Phosphoproteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D000097722:Cohesins
chemical_list: D034961:Antigens, Nuclear; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D049308:Dioxygenases; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D000097722:Cohesins; C473949:ASXL1 protein, human; C429022:RAD21 protein, human; C508565:STAG2 protein, human; C541081:TET2 protein, human