Surface functional polymers by post-polymerization modification using diarylcarbenes: introduction, release and regeneration of hydrogen peroxide and bactericidal activity.
Functionalized diarylcarbenes are excellent reactive intermediates suitable for the direct surface modification of organic polymers, and these may be used to introduce urea and thiourea functions onto polystyrene at loading levels of up to 2.3 x 10(13) molecules/cm(2). These functions are capable of the reversible binding and release of peroxide at loading levels of up to 0.6 mmol/g and give polymers that display biocidal activity against a spectrum of gram-positive and gram-negative bacteria.
Griffiths
Jon-Paul
JP
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Maliha
Bushra
B
Moloney
Mark G
MG
Thompson
Amber L
AL
Hussain
Ishtiaq
I
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D006841:Hydrocarbons, Aromatic; D011137:Polystyrenes; D006861:Hydrogen Peroxide