Uterine luminal epithelium-specific proline-rich acidic protein 1 (PRAP1) as a marker for successful embryo implantation.
Proline-rich acidic protein 1 mRNA is highly expressed in the uterine luminal epithelium (LE) of day 0.5 mouse uterus, disappears in the preimplantation day 3.5 uterus, and reappears abundantly in the LE after embryo implantation has occurred or upon artificial decidualization. In ovariectomized uterus, Prap1 is down-regulated by P, transiently down-regulated by E(2) treatment for 6 hours, but dramatically induced by E(2) treatment for 3 days.
Diao
Honglu
H
Department of Physiology and Pharmacology, College of Veterinary Medicine, Athens, GA 30602, USA.
Xiao
Shuo
S
Zhao
Fei
F
Ye
Xiaoqin
X
D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D010064:Embryo Implantation / Q000235:genetics*; D004622:Embryo, Mammalian / Q000378:metabolism; D047108:Embryonic Development / Q000187:drug effects / Q000235:genetics; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009928:Organ Specificity / Q000235:genetics; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D049368:Receptors, Lysophosphatidic Acid / Q000235:genetics; D015843:Serpins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D015415:Biomarkers; D006023:Glycoproteins; D011257:Pregnancy Proteins; D049368:Receptors, Lysophosphatidic Acid; D015843:Serpins; C414428:pregnant specific uterus protein, PSUP; C029708:uterine luminal fluid proteins; D004958:Estradiol