title: Granulocyte colony stimulating factor-induced exacerbation of fungus-related immune restoration inflammatory syndrome: a case of chronic disseminated candidiasis exacerbation.
abstract: Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.
authors.affiliation: Paris Descartes University, Assistance Publique-Hôpitaux de Paris, Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades Hospital, 149 rue de Sèvres, Paris Cedex 15, France. olivia.chandesris@nck.aphp.fr
authors.forename: Marie-Olivia
authors.initials: MO
authors.lastname: Chandesris
authors.forename: Charikleia
authors.initials: C
authors.lastname: Kelaidi
authors.forename: Frédéric
authors.initials: F
authors.lastname: Méchaï
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Bougnoux
authors.forename: Nicole
authors.initials: N
authors.lastname: Brousse
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Viard
authors.forename: Sylvain
authors.initials: S
authors.lastname: Poirée
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000368:Aged; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D019337:Hematologic Neoplasms / Q000188:drug therapy; D006651:Histocytochemistry; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology*; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008297:Male; D008853:Microscopy; D011860:Radiography, Abdominal; D013154:Spleen / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D007155:Immunologic Factors; D016179:Granulocyte Colony-Stimulating Factor