Non-human primate regulatory T cells: current biology and implications for transplantation.
Regulatory T cells (Treg) offer potential for improving long-term outcomes in cell and organ transplantation. The non-human primate model is a valuable resource for addressing issues concerning the transfer of Treg therapy to the clinic. Herein, we discuss the properties of non-human primate Treg and prospects for their evaluation in allotransplantation and xenotransplantation.
Dons
Eefje M
EM
Raimondi
Giorgio
G
Cooper
David K C
DK
Thomson
Angus W
AW
D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D002455:Cell Division; D005434:Flow Cytometry; D006801:Humans; D007156:Immunologic Memory; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008252:Macaca fascicularis; D011323:Primates; D012377:Rodentia; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology / Q000502:physiology* / Q000637:transplantation*; D014183:Transplantation, Heterologous / Q000276:immunology*
D015703:Antigens, CD; D007166:Immunosuppressive Agents