title: The bovine spleen: interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections.
abstract: Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss general aspects of innate immunity and the cells involved in this aspect of the response to infection. We also provide examples of specific splenic regulatory and effector mechanisms involved in the response to Babesia bovis, an important tick-borne hemoparasitic disease of cattle. Evidence for the regulatory and effector role of bovine splenic monocytes and DC both in directing a type-1 response through interaction with splenic NK cells and γδT-cells will be presented.
authors.affiliation: Animal Disease Research Unit, USDA-ARS, 3003 ADBF/WSU, Pullman, WA 99164-6630, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Goff
authors.forename: R G
authors.initials: RG
authors.lastname: Bastos
authors.forename: W C
authors.initials: WC
authors.lastname: Brown
authors.forename: W C
authors.initials: WC
authors.lastname: Johnson
authors.forename: D A
authors.initials: DA
authors.lastname: Schneider
mesh_terms: D000818:Animals; D016793:Babesia bovis; D001404:Babesiosis / Q000276:immunology; D002417:Cattle / Q000235:genetics / Q000276:immunology*; D002418:Cattle Diseases / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology; D018448:Models, Immunological; D022423:Myeloid Cells / Q000276:immunology; D009569:Nitric Oxide / Q000096:biosynthesis; D018512:Parasitemia / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D012333:RNA, Messenger / Q000235:genetics; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016207:Cytokines; D012333:RNA, Messenger; D009569:Nitric Oxide