P66SHC and ageing: ROS and TOR?
Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.
Pani
Giovambattista
G
Institute of General Pathology, Universita' Cattolica Medical School, Rome Italy. gpani@rm.unicatt.it
D000375:Aging / Q000473:pathology / Q000502:physiology; D000818:Animals; D031204:Caloric Restriction; D004249:DNA Damage; D004195:Disease Models, Animal; D005502:Food; D044882:Glucose Metabolism Disorders / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D051379:Mice; D008928:Mitochondria / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D057165:Proteostasis Deficiencies / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D019893:Ribosomal Protein S6 Kinases / Q000502:physiology*; D055765:Shc Signaling Adaptor Proteins / Q000502:physiology*; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D058570:TOR Serine-Threonine Kinases / Q000502:physiology*
D017382:Reactive Oxygen Species; D055765:Shc Signaling Adaptor Proteins; C528034:Shc1 protein, mouse; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D019893:Ribosomal Protein S6 Kinases; D058570:TOR Serine-Threonine Kinases