title: Objective and non-invasive evaluation of photorejuvenation effect with intense pulsed light treatment in Asian skin.
abstract: BACKGROUND
  Intense pulsed light (IPL) has been widely used for photorejuvenation. Although previous literature has shown clinical effectiveness of IPL treatments on cutaneous photoaging, the associated changes in the biophysical properties of the skin following IPL treatments have not been fully elucidated.
  
  
  OBJECTIVE
  The aim of this study was to evaluate changes in skin biophysical properties in patients with photoaging after IPL treatments, using non-invasive, objective skin measuring devices.
  
  
  METHODS
  A total of 26 Korean women with facial dyschromias underwent three sessions of IPL treatment at 4-week intervals. Outcome assessments included standardized photography, global evaluation by blinded investigators, patients' self-assessment and objective measurements of colour (Mexameter MX18, Chromatometer), elasticity (Cutometer), roughness (Visiometer), sebum (Sebumeter) and skin hydration (Corneometer). Results  Intense pulsed light treatments produced a 15% decrease in the size of representative pigmented lesions (P < 0.05). Patients' self-assessment revealed that 84% and 58% of subjects considered their pigmented lesions and wrinkles were improved respectively. Objective colorimetric measurement demonstrated significant improvements following IPL treatments that were most remarkable after one session of IPL. Moreover, skin elasticity showed significant improvements at the end of the study. Skin wrinkles as measured using Visiometer showed a mild improvement without statistical significance. Sebum secretion and water content of skin remained unchanged.
  
  
  CONCLUSIONS
  Intense pulsed light provided significant improvement in the appearance of facial pigmented lesions in Korean patients. These effects appeared to be more remarkable in improving pigmentation, skin tone and elasticity.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Gyeonggi, Korea.
authors.forename: J-W
authors.initials: JW
authors.lastname: Shin
authors.forename: D-H
authors.initials: DH
authors.lastname: Lee
authors.forename: S-Y
authors.initials: SY
authors.lastname: Choi
authors.forename: J-I
authors.initials: JI
authors.lastname: Na
authors.forename: K-C
authors.initials: KC
authors.lastname: Park
authors.forename: S-W
authors.initials: SW
authors.lastname: Youn
authors.forename: C-H
authors.initials: CH
authors.lastname: Huh
mesh_terms: D000328:Adult; D044466:Asian People; D005145:Face; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy; D008875:Middle Aged; D017060:Patient Satisfaction / Q000208:ethnology / Q000706:statistics & numerical data; D010859:Pigmentation Disorders / Q000208:ethnology* / Q000532:radiotherapy; D012060:Rejuvenation; D056910:Republic of Korea; D015595:Skin Aging / Q000208:ethnology* / Q000528:radiation effects; D016896:Treatment Outcome; D055815:Young Adult