Zhixue capsule caused seven cases of drug induced hepatitis.
OBJECTIVE
To report the recently 7 cases of drug induced hepatitis patients in our department.


METHODS
From October 2008 to December 2008, 7 patients were enrolled in our department for drug induced hepatitis caused by Zhixue capsules administration. The Zhixue capsule is composed of cortex dictam and radices sophorae flavescentis. There were 4 female and 3 male patients. The patients were of age 31 to 52 years old. Of those, 6 patients belonged to the hepatocellular injury type and one to the mixed type. The time period Zhixue capsule was administered was from 6 to 18 days. When the patients enrolled into our department, they were treated for jaundice and protective liver function.


RESULTS
When the patients were discharged the symptoms were all improved evidently and liver function became normal. One patient with mixed type was hospitalized for 63 days and he was treated with glucocorticoid to help his recovery.


CONCLUSIONS
Zhixue capsule could induce acute hepatitis of various types, but mainly hepatocellular injury type. The patients of all types could be recovered with proper treatment. The combined type may need glucocorticoid administration to help recovery.
Tai
Wei-Ping
WP
Department of Gastroenterology, Beijing Shijitan Hospital, Beijing 100038. taiweiping@hotmail.com
Yue
Hui
H
Zhai
Hong-Zhen
HZ
D000328:Adult; D002214:Capsules; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000628:therapy; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029909:Sophora / Q000009:adverse effects*
D002214:Capsules; D004365:Drugs, Chinese Herbal