Unusual "flesh-eating" strain of Escherichia coli.
We report an exceptional case of life-threatening Escherichia coli-induced necrotizing fasciitis. A combined host-pathogen genetic analysis explained the phenotype: the host displayed a susceptibility to intravascular coagulation, and the strain was capable of producing a necrotic toxin (cytotoxic necrotizing factor 1), showing how E. coli can be a dermonecrotic pathogen.
Grimaldi
David
D
Intensive Care Unit, Cochin University Hospital, 75014 Assistance Publique Hôpitaux de Paris, Paris, France. david.grimaldi@cch.aphp.fr
Bonacorsi
Stéphane
S
Roussel
Hélène
H
Zuber
Benjamin
B
Poupet
Hélène
H
Chiche
Jean-Daniel
JD
Poyart
Claire
C
Mira
Jean-Paul
JP
D000369:Aged, 80 and over; D001427:Bacterial Toxins / Q000096:biosynthesis; D004926:Escherichia coli / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000096:biosynthesis; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007866:Leg / Q000382:microbiology / Q000473:pathology; D008297:Male; D008853:Microscopy
D001427:Bacterial Toxins; D029968:Escherichia coli Proteins; C060296:cytotoxic necrotizing factor type 1