Immunoregulatory roles for fc receptor-like molecules.
Fc receptor-like (FCRL) molecules comprise a family of imunoregulatory transmembrane proteins that are preferentially, but not exclusively expressed on B lineage cells. A strong regulatory potential on B cell activation has been characterized for the different FCRL proteins, but their biological roles are just beginning to be elucidated. We review recent advances in the understanding of FCRL1-6 expression and function, and indicate their potential roles in the pathogenesis of immunodeficiencies, lymphoid malignancies and autoimmune diseases.
Ehrhardt
Götz R A
GR
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA. goetz.ehrhardt@emory.edu
Cooper
Max D
MD
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D011961:Receptors, Fc / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
D007141:Immunoglobulin Fc Fragments; D011961:Receptors, Fc