title: RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo.
abstract: The function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer.
authors.affiliation: The Chinese University of Hong Kong, Shatin, Hong Kong. b110796@mailserv.cuhk.edu.hk
authors.forename: Yangchao
authors.initials: Y
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Wing
authors.initials: W
authors.lastname: Yin Li
authors.forename: Chi
authors.initials: C
authors.lastname: Man Cheung
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.forename: Ching Yu
authors.initials: CY
authors.lastname: Chan
authors.forename: Chu-yan
authors.initials: CY
authors.lastname: Chan
authors.forename: Fang-Ping
authors.initials: FP
authors.lastname: Xu
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Liu
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: Hsiang-fu
authors.initials: HF
authors.lastname: Kung
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000378:metabolism / Q000556:secondary / Q000628:therapy*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D000071221:Enhancer of Zeste Homolog 2 Protein; D005260:Female; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D063151:Polycomb Repressive Complex 2; D034622:RNA Interference; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014162:Transfection; D047368:Tumor Burden; D015854:Up-Regulation; D023041:Xenograft Model Antitumor Assays
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2