title: Anisotropy of wave propagation in the heart can be modeled by a Riemannian electrophysiological metric.
abstract: It is well established that wave propagation in the heart is anisotropic and that the ratio of velocities in the three principal directions may be as large as v(f)v(s)v(n) approximately 4(fibers)2(sheets)1(normal). We develop an alternative view of the heart based on this fact by considering it as a non-Euclidean manifold with an electrophysiological(el-) metric based on wave velocity. This metric is more natural than the Euclidean metric for some applications, because el-distances directly encode wave propagation. We develop a model of wave propagation based on this metric; this model ignores higher-order effects like the curvature of wavefronts and the effect of the boundary, but still gives good predictions of local activation times and replicates many of the observed features of isochrones. We characterize this model for the important case of the rotational orthotropic anisotropy seen in cardiac tissue and perform numerical simulations for a slab of cardiac tissue with rotational orthotropic anisotropy and for a model of the ventricles based on diffusion tensor MRI scans of the canine heart. Even though the metric has many slow directions, we show that the rotation of the fibers leads to fast global activation. In the diffusion tensor MRI-based model, with principal velocities 0.25051 m/s, we find examples of wavefronts that eventually reach speeds up to 0.9 m/s and average velocities of 0.7 m/s. We believe that development of this non-Euclidean approach to cardiac anatomy and electrophysiology could become an important tool for the characterization of the normal and abnormal electrophysiological activity of the heart.
authors.affiliation: Institut des Hautes Etudes Scientifiques, 35 route de Chartres, 91440 Bures-sur-Yvette, France.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Young
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Panfilov
mesh_terms: D000818:Animals; D016880:Anisotropy; D055592:Biophysical Phenomena; D019295:Computational Biology; D004285:Dogs; D055724:Electrophysiological Phenomena; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008953:Models, Anatomic; D008955:Models, Cardiovascular