title: Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents.
abstract: An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 against M.luteus, K.pneumonia, 29, 30 against P.vulgaris exhibited excellent antibacterial activity at a minimum inhibitory concentration (MIC) value of 6.25 µg/mL. Compound 23 against M.gypseum, 25, 29 against Candida 6 and 29, 30 against C.albicans revealed excellent antifungal activity at a MIC value of 6.25 µg/mL.
authors.affiliation: Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Kanagarajan
authors.forename: J
authors.initials: J
authors.lastname: Thanusu
authors.forename: M
authors.initials: M
authors.lastname: Gopalakrishnan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D060729:Coal Ash; D005658:Fungi / Q000187:drug effects; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D052638:Particulate Matter / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D060729:Coal Ash; D048289:Imidazolidines; D052638:Particulate Matter; D013141:Spiro Compounds; D002244:Carbon