title: HDAC inhibitors - new generation of target specific treatment.
abstract: Histone Deacetylases (HDACs) enzymes are critical in regulating gene expression and transcription. They also play a fundamental role in regulating cellular activities such as cell proliferation, survival and differentiation. Inhibition of HDACs has generated many fascinating results including a new strategy in human cancer therapy. HDAC Inhibitors (HDACIs) like SAHA, TSA are emerging as new promising drugs for various anti-inflammatory and CNS-disorders. This review, along with chemical classification, emphasizes on the therapeutic potential of various HDACIs against different diseases.
authors.affiliation: Department of Medicinal Chemistry, Bharati Vidyapeeth's College of Pharmacy, CBD-Belapur, Navi Mumbai-400614, Maharashtra, India.
authors.forename: A V
authors.initials: AV
authors.lastname: Chavan
authors.forename: R R
authors.initials: RR
authors.lastname: Somani
mesh_terms: D000215:Acylation; D000818:Animals; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D056572:Histone Deacetylase Inhibitors; D006657:Histones