Zebrafish models of p53 functions.
Zebrafish models have significantly contributed to our understanding of vertebrate development and, more recently, human disease. The growing number of genetic tools available in zebrafish research has resulted in the identification of many genes involved in developmental and disease processes. In particular, studies in the zebrafish have clarified roles of the p53 tumor suppressor in the formation of specific tumor types, as well as roles of p53 family members during embryonic development. The zebrafish has also been instrumental in identifying novel mechanisms of p53 regulation and highlighting the importance of these mechanisms in vivo. This article will summarize how zebrafish models have been used to reveal numerous, important aspects of p53 function.
Storer
Narie Y
NY
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Zon
Leonard I
LI
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D023421:Models, Animal; D008957:Models, Genetic; D008967:Molecular Biology / Q000379:methods; D009687:Nuclear Proteins / Q000378:metabolism; D010750:Phosphoproteins; D012269:Ribosomal Proteins / Q000378:metabolism; D015534:Trans-Activators; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D015027:Zebrafish; D029961:Zebrafish Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D012269:Ribosomal Proteins; C488641:Tp63 protein, zebrafish; D015534:Trans-Activators; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D029961:Zebrafish Proteins