[Level of evidence for therapeutic drug monitoring for etoposide after oral administration].
Oral etoposide displays high inter- and intra-variability. Convincing relationships were observed between hematological toxicities and exposure of which total etoposide area under the curve seems the more relevant in routine practice. Linear pharmacokinetics, limited sampling strategies and reduction of variability during concentration-controlled studies argue in favor of therapeutic drug monitoring. For these reasons, such practice can be considered as recommended or potentially useful. Further studies using Bayesian approach are nevertheless needed to definitely state regarding the level of evidence therapeutic drug monitoring of oral etoposide.
Schieveen
Pauline Gerritsen-van
PG
CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Inserm U645, Université de Franche-Comté, Besançon, France.
Hulin
Anne
A
Muret
Patrice
P
Royer
Bernard
B
D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide