title: Multiplexed NMR: an automated CapNMR dual-sample probe.
abstract: A new generation of microscale, nuclear magnetic resonance (CapNMR) probe technology employs two independent detection elements to accommodate two samples simultaneously. Each detection element in the dual-sample CapNMR probe (DSP) delivers the same spectral resolution and S/N as in a CapNMR probe configured to accommodate one sample at a time. A high degree of electrical isolation allows the DSP to be used in a variety of data acquisition modes. Both samples are shimmed simultaneously to achieve high spectral resolution for simultaneous data acquisition, or alternatively, a flowcell-specific shim set is readily called via spectrometer subroutines to enable acquisition from one sample while the other is being loaded. An automation system accommodates loading of two samples via dual injection ports on an autosampler and two completely independent flowpaths leading to dedicated flowcells in the DSP probe.
authors.affiliation: Protasis/MRM Corporation, 101 West Tomaras Avenue, Savoy, Illinois 61874, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Norcross
authors.forename: Craig T
authors.initials: CT
authors.lastname: Milling
authors.forename: Dean L
authors.initials: DL
authors.lastname: Olson
authors.forename: Duanxiang
authors.initials: D
authors.lastname: Xu
authors.forename: Anthony
authors.initials: A
authors.lastname: Audrieth
authors.forename: Robert
authors.initials: R
authors.lastname: Albrecht
authors.forename: Ke
authors.initials: K
authors.lastname: Ruan
authors.forename: John
authors.initials: J
authors.lastname: Likos
authors.forename: Claude
authors.initials: C
authors.lastname: Jones
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Peck
mesh_terms: D001331:Automation; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*