Platelet reactivity and pregnancy loss.
OBJECTIVE
We sought to critically evaluate platelet function in recurrent miscarriage (RM).


METHODS
We conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.


RESULTS
At test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.


CONCLUSIONS
This novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.
Flood
Karen
K
Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Peace
Aaron
A
Kent
Etaoin
E
Tedesco
Tony
T
Dicker
Patrick
P
Geary
Michael
M
Malone
Fergal D
FD
Kenny
Dermot
D
D000026:Abortion, Habitual / Q000097:blood*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D016718:Arachidonic Acid / Q000494:pharmacology; D016022:Case-Control Studies; D024042:Collagen Type I / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies
D024042:Collagen Type I; D010446:Peptide Fragments; C086309:thrombin receptor peptide SFLLRNP; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D004837:Epinephrine