title: Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume.
abstract: One of the most significant challenges implementing colloidal magnetic nanoparticles in medicine is the efficient heating of microliter quantities by applying a low frequency alternating magnetic field. The ultimate goal is to accomplish nonsurgically the treatment of millimeter size tumors. Here, we demonstrate the synthesis, characterization, and the in vitro as well as in vivo efficiency of a dextran coated maghemite (gamma-Fe(2)O(3)) ferrofluid with an exceptional response to magnetic heating. The difference to previous synthetic attempts is the high charge of the dextran coating, which according to our study maintains the colloidal stability and good dispersion of the ferrofluid during the magnetic heating stage. Specifically, in vitro 2 mul of the ferrofluid gives an outstanding temperature rise of 33 degrees C within 10 min, while in vivo treatment, by infusing 150 mul of the ferrofluid in animal model (rat) glioma tumors, causes an impressive cancer tissue dissolution.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Rabias
authors.forename: Danai
authors.initials: D
authors.lastname: Tsitrouli
authors.forename: Eleni
authors.initials: E
authors.lastname: Karakosta
authors.forename: Thomas
authors.initials: T
authors.lastname: Kehagias
authors.forename: Georgios
authors.initials: G
authors.lastname: Diamantopoulos
authors.forename: Michael
authors.initials: M
authors.lastname: Fardis
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Stamopoulos
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Maris
authors.forename: Polykarpos
authors.initials: P
authors.lastname: Falaras
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zouridakis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Diamantis
authors.forename: Georgios
authors.initials: G
authors.lastname: Panayotou
authors.forename: Dimitrios A
authors.initials: DA
authors.lastname: Verganelakis
authors.forename: Garyfalia I
authors.initials: GI
authors.lastname: Drossopoulou
authors.forename: Effie C
authors.initials: EC
authors.lastname: Tsilibari
authors.forename: Georgios
authors.initials: G
authors.lastname: Papavassiliou