Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma.
Bordetella bronchiseptica is a gram negative coccobacillus that can be transmitted from domestic animals and cause severe infections in immunocompromised patients. A 56-year-old man with a left parietal glioblastoma was treated with resection, radiation and concomitant and adjuvant temozolomide chemotherapy. He received bevacizumab for progression, and dose dense metronomic temozolomide was added for additional progression. He developed chronic cough and was diagnosed with B. bronchiseptica infection. This is the first reported case of B. bronchiseptica infection in a patient receiving temozolomide. The infection was likely acquired from an infected kitten. Patients receiving temozolomide should be counseled on the risks of acquiring zoonotic infections, including B. bronchiseptica, from their pets.
Redelman-Sidi
Gil
G
Department of Medicine, Infectious Disease, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. redelmansidi@hotmail.com
Grommes
Christian
C
Papanicolaou
Genovefa
G
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001885:Bordetella Infections / Q000382:microbiology / Q000635:transmission*; D016950:Bordetella bronchiseptica / Q000302:isolation & purification*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002415:Cats; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011879:Radiotherapy Dosage; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000635:transmission*; D000077204:Temozolomide; D015047:Zoonoses / Q000382:microbiology*
D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide