title: Assessment of genetic contributions to risk of preeclampsia in Ecuadorian women.
abstract: OBJECTIVE
  To identify the immunogenetic factors that trigger the beginning of preeclampsia and eclampsia.
  
  
  METHODS
  A retrospective, case-control study of 142 pregnant women in Obstetrics and Gynecological Hospital Isidro Ayora in Quito, who are grouped into two different groups, diseased and healthy. The study analyzed ethnicity, age, gynecological history, contraception, immunizations, blood type and Rh factor, and family history of preeclampsia-eclampsia of each of the pregnant women; and gestational age, sex, weight, and blood type and Rh factor of the progeny.
  
  
  RESULTS
  Age, ethnicity, history of pregnancy, abortions, contraception, and blood type and Rh factor were similar for both groups (p > 0.05). Gestational age and weight of the progeny was lower in cases compared with controls (p < 0.05). There was no statistical difference when comparing the blood type and Rh factor of the two groups (p > 0.05). Male gender was predominant in both groups for cases 69.01 and 87.32% for controls (p < 0.05).
  
  
  CONCLUSIONS
  There was a higher predisposition for inherited cases (26%) versus controls (9.85%), p < 0.05, for the occurrence of preeclampsia. The frequency of the recessive gene for Mendelian inheritance model mother-fetus homozygous (aa/aa), in agreement with the Hardy-Weinberg Law, was 0.41 for the sample.
authors.affiliation: Biomedical Center, Universidad Central (Quito) and UniAndes (Ambato), Ecuador.
authors.forename: Ramiro
authors.initials: R
authors.lastname: López-Pulles
authors.forename: Fabricio
authors.initials: F
authors.lastname: González-Andrade
authors.forename: Mario
authors.initials: M
authors.lastname: Durán-Rodas
authors.forename: José
authors.initials: J
authors.lastname: Ayala
authors.forename: Richard
authors.initials: R
authors.lastname: Carrillo
authors.forename: Luis René
authors.initials: LR
authors.lastname: Buitrón
authors.forename: Juan
authors.initials: J
authors.lastname: Chuga
authors.forename: Walter
authors.initials: W
authors.lastname: Moya
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004484:Ecuador; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies; D012306:Risk; D012720:Severity of Illness Index