Relationships between structures of hydroxyflavones and their antioxidative effects.
Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3',4'-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure-activity relationships were examined.
Hyun
Jiye
J
Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Republic of Korea.
Woo
Yoonkyung
Y
Hwang
Do-Seok
DS
Jo
Geunhyeong
G
Eom
Sunglock
S
Lee
Younggiu
Y
Park
Jun Cheol
JC
Lim
Yoongho
Y
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D044948:Flavonols; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship
D000975:Antioxidants; D047309:Flavones; D005419:Flavonoids; D044948:Flavonols; D016166:Free Radical Scavengers; C037032:galangin; C017875:fisetin