title: Oppositinines A and B: new vasorelaxant beta-carboline alkaloids from Neisosperma oppositifolia.
abstract: A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, University Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
authors.forename: Kartini
authors.initials: K
authors.lastname: Ahmad
authors.forename: Noel F
authors.initials: NF
authors.lastname: Thomas
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: Khalit
authors.initials: K
authors.lastname: Mohamad
authors.forename: Mohd Azlan
authors.initials: MA
authors.lastname: Nafiah
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Hiroko
authors.initials: H
authors.lastname: Arai
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D029062:Apocynaceae / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002243:Carbolines; D010936:Plant Extracts; D014665:Vasodilator Agents; C553891:oppositinine A; C553892:oppositinine B; D009569:Nitric Oxide