Lack of association of NALCN genetic variants with schizophrenia.
NALCN (sodium leak channel, non-selective) is located on chromosome 13q (suggested linkage region for schizophrenia). We analyzed 21 polymorphisms in 464 schizophrenia subjects, 220 controls subjects and 119 small nuclear families. We observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.
Souza
Renan P
RP
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada. renanrps@yahoo.com
Rosa
Daniela V F
DV
Romano-Silva
Marco A
MA
Zhen
Mei
M
Meltzer
Herbert Y
HY
Lieberman
Jeffrey A
JA
Remington
Gary
G
Kennedy
James L
JL
Wong
Albert H C
AH
D000328:Adult; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D015222:Sodium Channels / Q000235:genetics*
D007473:Ion Channels; D008565:Membrane Proteins; C544681:NALCN protein, human; D015222:Sodium Channels