title: [Clinical predictors of growth response in the first year of treatment with a fixed dose of growth hormone in children born small for gestational age].
abstract: OBJECTIVE
  To identify clinical predictors associated with catch-up growth in the first year of treatment with somatropin (rhGH) in a group of children born small for gestational age (SGA).
  
  
  METHODS
  Thirty nine children who have been on rhGH therapy for at least one year (0.33 mg/kg/week) were evaluated. The clinical parameters analyzed were chronological age (CA), bone age (BA), target height and standard deviations scores (SDS) of birth weight and length, height, weight and growth rate.
  
  
  RESULTS
  rhGH therapy was associated with a first year height increment of 0.67 SDS (p < 0.01). BA and birth weight SDS were predictive of growth response, with statistical difference in height SDS variation between prepubertal and pubertal subgroups (p = 0.016).
  
  
  CONCLUSIONS
  These data show a significant growth response with a fixed rhGH dose, those children who started rhGH in prepubertal ages presented the best outcomes.
authors.affiliation: Departamento de Endocrinologia e Metabologia, Hospital de Base do Distrito Federal, Brasília, DF, Brasil. adrianafurtado@terra.com.br
authors.forename: Adriana Claudia Lopes Carvalho
authors.initials: AC
authors.lastname: Furtado
authors.forename: Luiz Claudio Gonçalves de
authors.initials: LC
authors.lastname: Castro
authors.forename: Marcelo Palmeira
authors.initials: MP
authors.lastname: Rodrigues
authors.forename: Luciana Ansaneli
authors.initials: LA
authors.lastname: Naves
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development*; D008297:Male; D011237:Predictive Value of Tests; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone