title: Pathologic fracture of the femur due to endometrial adenocarcinoma metastasis in a female pet rabbit (Oryctolagus cuniculi).
abstract: This case report describes the clinical, pathomorphological and histopathological findings in a 12-year-old female pet rabbit with a pathologic fracture of the femur due to a metastasising endometrial adenocarcinoma. The animal was presented due to a history of right hindlimb lameness and inappetence. A fracture of the right femur with adjacent lyric bone lesions was detected by clinical and X-ray examination. Necropsy and histopathology revealed an endometrial adenocarcinoma with metastasis to the right femoral bone, resulting in the pathologic fracture. In both locations, tumour cells were immunohistochemically positive for pan-cytokeratin. Additionally, the animal suffered from an Encephalitozoon cuniculi infection which manifested itself in a multifocal granulomatous encephalitis and bilateral chronic inflammatory lesions in the kidneys.The report shows that in case of bone fractures in female pet rabbits the possibility of a pathologic fracture due to metastasising endometrial adenocarcinoma has to be considered.
authors.affiliation: Institute of Pathology, University of Veterinary Medicine Hannover. verena.haist@tiho-hannover.de
authors.forename: Verena
authors.initials: V
authors.lastname: Haist
authors.forename: Simon Gonzales
authors.initials: SG
authors.lastname: Hirschfeld
authors.forename: Carolin
authors.initials: C
authors.lastname: Mallig
authors.forename: Michael
authors.initials: M
authors.lastname: Fehr
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Baumgärtner
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000829:Animals, Domestic; D016889:Endometrial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D009362:Neoplasm Metastasis; D011817:Rabbits; D011859:Radiography / Q000662:veterinary