title: Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy.
abstract: At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together with their possibilities and limitations from fabrication to application in drug delivery. In addition, the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes are described.
authors.affiliation: National Cell Bank, Pasteur Institute of Iran, Tehran 1316943551, Iran. mahmoudi@biospion.com
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
authors.forename: Shilpa
authors.initials: S
authors.lastname: Sant
authors.forename: Ben
authors.initials: B
authors.lastname: Wang
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Tapas
authors.initials: T
authors.lastname: Sen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles