title: Immune activation and neuropsychiatric symptoms in HIV infection.
abstract: This study examined the role of biological processes in the development of specific neuropsychiatric complications in HAART-naive adults with HIV/AIDS. Depressive symptoms were modestly associated with elevated IL-6 mRNA expression (r(s)=0.40, p<0.05) even after removing the influences of other subjective complaints (pr=0.39, p<0.05). Elevated serum neopterin was strongly associated with depressive symptoms in individuals taking antidepressants (r(s)=0.83, p<0.001), though the association was nullified in those not on antidepressants (r(s)=-0.25, p>0.05). Mean neopterin levels were higher in the depressed as compared with nondepressed group but only for those taking antidepressants (F=45.66, df=1, 11, p<0.001). Neuropsychological impairment was not associated with the biological markers. These findings suggest that systemic immune markers (like neopterin) may be useful in differentiating treatment-resistant individuals at greater risk of developing chronic depression.
authors.affiliation: St. Michael's Hospital, Neurobehavioural Research Unit in HIV/AIDS, 30 Bond Street, Shuter Wing, Rm. 2-044, Toronto, ON, M5B 1W8.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Warriner
authors.forename: Sean B
authors.initials: SB
authors.lastname: Rourke
authors.forename: Byron P
authors.initials: BP
authors.lastname: Rourke
authors.forename: Sarah
authors.initials: S
authors.lastname: Rubenstein
authors.forename: Colleen
authors.initials: C
authors.lastname: Millikin
authors.forename: Lori
authors.initials: L
authors.lastname: Buchanan
authors.forename: Phil
authors.initials: P
authors.lastname: Connelly
authors.forename: Martin
authors.initials: M
authors.lastname: Hyrcza
authors.forename: Mario
authors.initials: M
authors.lastname: Ostrowski
authors.forename: Sandy
authors.initials: S
authors.lastname: Der
authors.forename: Kevin
authors.initials: K
authors.lastname: Gough
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003863:Depression / Q000150:complications* / Q000276:immunology / Q000523:psychology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000523:psychology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D019798:Neopterin / Q000097:blood / Q000276:immunology; D009483:Neuropsychological Tests; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019798:Neopterin