title: Management of oral carcinoma: benefits of early precancerous intervention.
abstract: Management of oral precancerous lesions remains polarised between interventional surgery and conservative treatment. We have previously shown the efficacy of carbon dioxide laser excision for both diagnosis and treatment of oral precancerous lesions. The aim of this study was to review the clinicopathological details of a group of patients in whom pre-existing but occult invasive carcinoma was diagnosed histopathologically in specimens excised by laser. We retrospectively reviewed 169 patients who attended the Maxillofacial Dysplasia Clinic at Newcastle General Hospital with single, new oral premalignant lesions over a 5-year period (2004-2008). They were all treated by laser excision of lesions that were confirmed to be dysplastic from examination of preoperative incisional biopsy specimens. There was a significant correlation between the results of diagnostic incisional, and laser excision, biopsy specimens (p < 0.01), but 15 patients had signs of occult invasive carcinoma in the excision specimens (9%). In all cases the carcinomas were completely excised by the laser. Carbon dioxide laser excision is not only an effective treatment of precancerous lesions, but also facilitates early diagnosis and management of oral carcinoma at a stage when it is otherwise clinically undetectable.
authors.affiliation: Oral & Maxillofacial Surgery, School of Dental Sciences, Framlington Place, Newcastle upon Tyne, UK.
authors.forename: M L
authors.initials: ML
authors.lastname: Goodson
authors.forename: P J
authors.initials: PJ
authors.lastname: Thomson
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D002245:Carbon Dioxide; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000601:surgery*; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide