title: Agenesis of maxillary lateral incisors and associated dental anomalies.
abstract: BACKGROUND
  The objectives of this study were to evaluate the prevalence of dental anomalies in patients with agenesis of maxillary lateral incisors and to compare the findings with the prevalence of these anomalies in the general population.
  
  
  METHODS
  A sample of 126 patients, aged 7 to 35 years, with agenesis of at least 1 maxillary lateral incisor was selected. Panoramic and periapical radiographs and dental casts were used to analyze other associated dental anomalies, including agenesis of other permanent teeth, ectopia of unerupted permanent teeth, microdontia of maxillary lateral incisors, and supernumerary teeth. The occurrence of these anomalies was compared with prevalence data previously reported for the general population. Statistical testing was performed with the chi-square test (P <0.05) and the odds ratio.
  
  
  RESULTS
  Patients with maxillary lateral incisor agenesis had a significantly increased prevalence rate of permanent tooth agenesis (18.2%), excluding the third molars. The occurrence of third-molar agenesis in a subgroup aged 14 years or older (n = 76) was 35.5%. The frequencies of maxillary second premolar agenesis (10.3%), mandibular second premolar agenesis (7.9%), microdontia of maxillary lateral incisors (38.8%), and distoangulation of mandibular second premolars (3.9%) were significantly increased in our sample compared with the general population. In a subgroup of patients aged 10 years or older (n = 115), the prevalence of palatally displaced canines was elevated (5.2%). The prevalences of mesioangulation of mandibular second molars and supernumerary teeth were not higher in the sample.
  
  
  CONCLUSIONS
  Permanent tooth agenesis, maxillary lateral incisor microdontia, palatally displaced canines, and distoangulation of mandibular second premolars are frequently associated with maxillary lateral incisor agenesis, providing additional evidence of a genetic interrelationship in the causes of these dental anomalies.
authors.affiliation: Department of Orthodontics, Hospital of Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, Brazil. dgarib@uol.com.br
authors.forename: Daniela Gamba
authors.initials: DG
authors.lastname: Garib
authors.forename: Bárbara Maria
authors.initials: BM
authors.lastname: Alencar
authors.forename: José Roberto Pereira
authors.initials: JR
authors.lastname: Lauris
authors.forename: Tiziano
authors.initials: T
authors.lastname: Baccetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000848:Anodontia / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D001641:Bicuspid / Q000002:abnormalities; D001938:Brazil / Q000453:epidemiology; D016009:Chi-Square Distribution; D002648:Child; D003481:Cuspid / Q000002:abnormalities; D019229:Dentition, Permanent; D005260:Female; D006801:Humans; D007180:Incisor / Q000002:abnormalities*; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012744:Sex Ratio; D014071:Tooth Abnormalities / Q000235:genetics*; D014079:Tooth Eruption, Ectopic / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult