[Study on estimation of radiation dose using FTIR in mice thymus].
Fourier transform infrared spectroscopy (FTIR) was applied to study the biochemical changes in the radiation damaged mouse thymus which increased with radiation dose and provided a new method for the estimation of the radiation dose of radiation damaged patients. The results demonstrated that with the dose increasing, the peak positions like 1 550, 1 400, 1 400 and 1 640 cm(-1) at the dose of 2, 3 and 5 Gy showed some difference, and there was obvious variance in the intensity: (1) The intensity ratio of 1 085 to 1 236 cm(-1) related to nucleic acid tended to decrease. (2) The intensity ratio of 1 640/1 550 decreased. (3) The intensity at 2 958, 2 925, 1 460 and 1 400 cm(-1) showed no significant difference. The results suggest that it may be possible for FTIR to become an effective method to estimate the radiation dose in clinic.
Wu
Wen-An
WA
First Hospital of Xi'an Jiaotong University, Xi'an 710061, China. wu2007.2010@stu.xjtu.edu.cn
Wang
Jian-Sheng
JS
Zhang
Jia
J
Mo
Fei
F
Wang
Si-Cen
SC
Zhou
Su-Na
SN
Zhang
Ming-Xin
MX
Xu
Yi-Zhuang
YZ
Shi
Jing-Sen
JS
Wu
Jin-Guang
JG
D000818:Animals; D051379:Mice; D011829:Radiation Dosage; D017550:Spectroscopy, Fourier Transform Infrared; D013950:Thymus Gland / Q000528:radiation effects*