[A case of localized malignant pleural mesothelioma].
A 74-year-old man was referred to our hospital for examination of an abnormal chest shadow. A chest computed tomography (CT) scan revealed a 5-cm mass attached to the pleura involving the right upper lobe, and a nodule in the right middle lobe. Transbronchial lung biopsy was performed twice, but no definitive diagnosis was achieved. 18-fluorodeoxyglucose positron emission tomography showed abnormal uptake in the chest lesion. Chemotherapy was initiated for advanced-stage lung cancer, but was not effective. Histopathologic and immunohistochemical examinations after CT-guided needle biopsy revealed malignant mesothelioma. The tumor cells were positive for calretinin and thrombomodulin, and negative for CEA, TTF-1, and SP-A. There was local tumor invasion and metastasis in the lung and brain, without diffuse pleural spread. This is a rare and important case of localized malignant mesothelioma pathologically confirmed by biopsy.
Tamura
Etsuko
E
Department of Respiratory Medicine, Kyushu Rosai Hospital.
Kozaki
Minako
M
Kunimoto
Masamizu
M
Tokuyama
Susumu
S
Kawanami
Yukiko
Y
Watanabe
Hideyuki
H
Hamada
Tetsuo
T
Morooka
Mitsuyuki
M
Mukae
Hiroshi
H
D000368:Aged; D006801:Humans; D008297:Male; D010997:Pleural Neoplasms / Q000473:pathology*; D054363:Solitary Fibrous Tumor, Pleural / Q000473:pathology*