title: tRNA and cytochrome c in cell death and beyond.
abstract: Both transfer RNA (tRNA) and cytochrome c are essential to cellular function: tRNA mediates protein synthesis while cytochrome c is required for oxidative phosphorylation and apoptosis induction. tRNA has recently been implicated as a direct regulator of the well-conserved apoptotic role of cytochrome c. Interaction between these molecules could potentially coordinate biosynthesis, energy production and apoptosis. Here we review the diversity and dynamics of tRNA and how this class of non-coding RNAs may regulate the role of cytochrome c in apoptosis. We comment on unanswered questions in the cell biology of this interaction and how answers may influence our understanding of disease.
authors.affiliation: Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Yide
authors.initials: Y
authors.lastname: Mei
authors.forename: Jeongsik
authors.initials: J
authors.lastname: Yong
authors.forename: Aaron
authors.initials: A
authors.lastname: Stonestrom
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D016923:Cell Death; D045304:Cytochromes c / Q000378:metabolism*; D004194:Disease / Q000235:genetics; D006801:Humans; D011485:Protein Binding; D012343:RNA, Transfer / Q000378:metabolism*
chemical_list: D045304:Cytochromes c; D012343:RNA, Transfer