title: International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.
abstract: OBJECTIVE
  To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.
  
  
  METHODS
  Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed.
  
  
  RESULTS
  Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver.
  
  
  CONCLUSIONS
  These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used.
authors.affiliation: Imperial College and Royal Brompton Hospital, London, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Kirk
authors.forename: Taigang
authors.initials: T
authors.lastname: He
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Anderson
authors.forename: Michael
authors.initials: M
authors.lastname: Roughton
authors.forename: Mark A
authors.initials: MA
authors.lastname: Tanner
authors.forename: Wynnie W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Wing Y
authors.initials: WY
authors.lastname: Au
authors.forename: Winnie C W
authors.initials: WC
authors.lastname: Chu
authors.forename: Godfrey
authors.initials: G
authors.lastname: Chan
authors.forename: Renzo
authors.initials: R
authors.lastname: Galanello
authors.forename: Gildo
authors.initials: G
authors.lastname: Matta
authors.forename: Mark
authors.initials: M
authors.lastname: Fogel
authors.forename: Alan R
authors.initials: AR
authors.lastname: Cohen
authors.forename: Ru San
authors.initials: RS
authors.lastname: Tan
authors.forename: Kevin
authors.initials: K
authors.lastname: Chen
authors.forename: Ivy
authors.initials: I
authors.lastname: Ng
authors.forename: Angie
authors.initials: A
authors.lastname: Lai
authors.forename: Suthat
authors.initials: S
authors.lastname: Fucharoen
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Laothamata
authors.forename: Suporn
authors.initials: S
authors.lastname: Chuncharunee
authors.forename: Sutipong
authors.initials: S
authors.lastname: Jongjirasiri
authors.forename: David N
authors.initials: DN
authors.lastname: Firmin
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Smith
authors.forename: Dudley J
authors.initials: DJ
authors.lastname: Pennell
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D015588:Observer Variation; D012016:Reference Values; D015203:Reproducibility of Results; D013789:Thalassemia / Q000097:blood*
chemical_list: D007501:Iron