title: DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology.
abstract: Oligonucleotides have recently gained increased attraction as a supramolecular scaffold for the design and synthesis of functional molecules on the nanometre scale. This tutorial review focuses on the recent progress in this highly active field of research with an emphasis on covalent modifications of DNA; non-covalent interactions of DNA with molecules such as groove binders or intercalators are not part of this review. Both terminal and internal modifications are covered, and the various points of attachment (nucleobase, sugar moiety or phosphodiester backbone) are compared. Using selected examples of the recent literature, the diversity of the functionalities that have been incorporated into DNA strands is discussed.
authors.affiliation: University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ, UK.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Bandy
authors.forename: Ashley
authors.initials: A
authors.lastname: Brewer
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Burns
authors.forename: Gabriella
authors.initials: G
authors.lastname: Marth
authors.forename: Thaonguyen
authors.initials: T
authors.lastname: Nguyen
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
mesh_terms: D004247:DNA / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D036103:Nanotechnology; D009711:Nucleotides / Q000737:chemistry
chemical_list: D008670:Metals; D009711:Nucleotides; D004247:DNA