Applications of MALDI-MSI to pharmaceutical research.
MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections.
Prideaux
Brendan
B
Analytical Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Staab
Dieter
D
Stoeckli
Markus
M
D000818:Animals; D003373:Coumaric Acids / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D051379:Mice; D051381:Rats; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry
D003373:Coumaric Acids; C007175:alpha-cyano-4-hydroxycinnamate