title: Managing patients receiving sorafenib for advanced hepatocellular carcinoma: a case study.
abstract: Despite improvements in cytotoxic chemotherapy agents over the last 50 years, the outlook for patients with many of the most common solid tumours has remained poor. However, in recent years a number of targeted therapies have been licensed in the European Union for use in these cancer types. One such therapy, a tyrosine kinase inhibitor (sorafenib) is now used to treat patients with advanced hepatocellular carcinoma (HCC) and metastatic renal cell carcinoma. This article will explore the role of the oncology nurse in managing patients receiving sorafenib for advanced HCC. A brief overview of sorafenib as a current treatment approved for advanced HCC in the palliative setting is presented. This is followed by a case study-based discussion with particular reference to some of the key care coordination challenges facing the oncology nurse. The management of treatment-related adverse events and the importance of using a multidisciplinary team approach is also reviewed.
authors.affiliation: Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, The University of Birmingham, Edgbaston, Birmingham, UK. d.hull@bham.ac.uk
authors.forename: Diana
authors.initials: D
authors.lastname: Hull
authors.forename: Ceri
authors.initials: C
authors.lastname: Armstrong
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000009:adverse effects / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000451:nursing; D003266:Continuity of Patient Care; D003967:Diarrhea / Q000139:chemically induced; D003875:Drug Eruptions / Q000209:etiology; D016903:Drug Monitoring / Q000451:nursing; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008113:Liver Neoplasms / Q000188:drug therapy / Q000451:nursing; D009536:Niacinamide / Q000031:analogs & derivatives; D024802:Nurse's Role; D009859:Oncology Nursing; D010348:Patient Care Team / Q000458:organization & administration; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011725:Pyridines / Q000009:adverse effects / Q000627:therapeutic use*; D012449:Safety; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib