title: Asymmetrical contribution of brain structures to treatment-resistant depression as illustrated by effects of right subgenual cingulum stimulation.
abstract: Major depressive disorder is one of the most common psychiatric disorders, with a worldwide lifetime prevalence rate of 10%-20% in women and a slightly lower rate in men. While many patients are successfully treated using established therapeutic strategies, a significant percentage of patients fail to respond. This report describes the successful recovery of a previously treatment-resistant patient following right unilateral deep brain stimulation of Brodmann's area 25. Current therapeutic approaches to treatment-resistant patients are reviewed in the context of this case with an emphasis on the role of the right and left hemispheres in mediating disease pathogenesis and clinical recovery.
authors.affiliation: FLENI, Cognitive Neurology & Neuropsychiatry, Montañeses 2325 8th floor, C1428AQK Buenos Aires, Argentina. sguinjoan@fleni.org.ar
authors.forename: Salvador M
authors.initials: SM
authors.lastname: Guinjoan
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: Elsa Y
authors.initials: EY
authors.lastname: Costanzo
authors.forename: Rodolfo D
authors.initials: RD
authors.lastname: Fahrer
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tenca
authors.forename: Julio
authors.initials: J
authors.lastname: Antico
authors.forename: Daniel
authors.initials: D
authors.lastname: Cerquetti
authors.forename: Elisa
authors.initials: E
authors.lastname: Smyth
authors.forename: Ramón C
authors.initials: RC
authors.lastname: Leiguarda
authors.forename: Charles B
authors.initials: CB
authors.lastname: Nemeroff
mesh_terms: D001921:Brain / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000379:methods*; D003865:Major Depressive Disorder / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome