title: [Level of evidence for therapeutic drug monitoring for etoposide after oral administration].
abstract: Oral etoposide displays high inter- and intra-variability. Convincing relationships were observed between hematological toxicities and exposure of which total etoposide area under the curve seems the more relevant in routine practice. Linear pharmacokinetics, limited sampling strategies and reduction of variability during concentration-controlled studies argue in favor of therapeutic drug monitoring. For these reasons, such practice can be considered as recommended or potentially useful. Further studies using Bayesian approach are nevertheless needed to definitely state regarding the level of evidence therapeutic drug monitoring of oral etoposide.
authors.affiliation: CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Inserm U645, Université de Franche-Comté, Besançon, France.
authors.forename: Pauline Gerritsen-van
authors.initials: PG
authors.lastname: Schieveen
authors.forename: Anne
authors.initials: A
authors.lastname: Hulin
authors.forename: Patrice
authors.initials: P
authors.lastname: Muret
authors.forename: Bernard
authors.initials: B
authors.lastname: Royer
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide