A new rhodamine-based chemosensor for Cu2+ and the study of its behaviour in living cells.
A new rhodamine-based chemosensor (L1) was synthesized, and it exhibits high sensitivity and selectivity for the copper cation over other commonly coexistent metal ions in aqueous solution. Upon the addition of Cu(2+), the spirolactam ring of L1 was opened and a 1 : 1 metal-ligand complex was formed. Fluorescent imaging of Cu(2+) in living cells is also successfully demonstrated.
Huang
Liang
L
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.
Wang
Xiao
X
Xie
Guoqiang
G
Xi
Pinxian
P
Li
Zhengpeng
Z
Xu
Min
M
Wu
Yongjie
Y
Bai
Decheng
D
Zeng
Zhengzhi
Z
D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D005456:Fluorescent Dyes; D006801:Humans; D015394:Molecular Structure; D012235:Rhodamines / Q000737:chemistry* / Q000378:metabolism*; D012996:Solutions
D005456:Fluorescent Dyes; D012235:Rhodamines; D012996:Solutions; D003300:Copper