Frontal intraparenchymal schwannoma.
A 39-year-old female had been subject to headache, and intermittent seizures for 9 years and decreasing memory for one year, without obvious neurological signs. An MRI revealed a 2x2 cm contrast-enhanced lesion in the frontal lobe, with a cyst and peritumoral edema, which was not attached to the dura or falx. Preoperatively, it was diagnosed as a glioma. Total surgical removal of the lesion led to a favorable result. Post-operative histo-pathological examination showed characteristic Antoni A and B areas consistent with intraparenchymal schwannoma. Intraparenchymal schwannoma is an extremely uncommon lesion, which is seen mostly in young adults and children. The main clinical symptoms include rising-intracranial-pressure-related manifestations and associated seizure disorders. The possible developmental origins, histological, imaging features, and protocols of treatment for this entity are discussed.
Luan
Shi-Hai
SH
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai Neurosurgical Center, Shanghai, China.
Gao
Xiang
X
Sun
Lin-Lin
LL
Huang
Feng-Ping
FP
D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D018396:Mucin-1 / Q000378:metabolism; D009442:Neurilemmoma / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin