A history of prior bare metal stent restenosis is associated with major adverse cardiac events in subsequent bare metal stenting of de novo coronary lesions.
OBJECTIVE
To investigate the risk of major adverse cardiac events (MACE) in patients with a history of bare metal stent (BMS) restenosis who undergo subsequent bare metal stenting of a geographically distinct, de novo coronary lesion.


METHODS
We conducted a retrospective review of 72 BMS procedures performed in geographically distinct, de novo coronary lesions in patients with a history of previous BMS placement at least 3 months prior to the second, index stent procedure. Patients with a history of in-stent restenosis (ISR) were compared with those who had no ISR in their initial stent.


RESULTS
Restenosis in the initial BMS was associated with a significant increase in MACE after placement of the index BMS (OR 20.0, 95% CI 3.86-103.58, p < 0.0001). This association was independent of traditional clinical and angiographic risk factors for restenosis.


CONCLUSIONS
Restenosis of a previously placed BMS is strongly associated with MACE after placement of a subsequent BMS in a de novo coronary lesion.
Ferguson
Michael A
MA
Department of Cardiology, National Naval Medical Center8901 Wisconsin AvenueBethesda, MD 20889, USA. drmfergus@yahoo.com
Needleman
Matthew
M
Mitchell
Eric S
ES
Carter
Luther I
LI
Bustamante
Alexander I
AI
Love
Kathleen M
KM
Curran
Michael J
MJ
D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications / Q000628:therapy; D003324:Coronary Artery Disease / Q000209:etiology*; D023903:Coronary Restenosis / Q000150:complications* / Q000628:therapy; D003430:Cross-Sectional Studies; D005260:Female; D006772:Hospitals, Military; D006801:Humans; D016015:Logistic Models; D008297:Male; D008670:Metals; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D014481:United States
D008670:Metals