title: Reversible cytotoxic oedema in the splenium of the corpus callosum related to tetracycline therapy.
abstract: We report a symptomatic girl with reversible circumscribed cytotoxic oedema in the splenium of the corpus callosum (CC) that occurred, to our knowledge, for the first time in relation to tetracycline treatment. After stopping tetracycline therapy the girl recovered completely and the CC lesion, clearly visible on diffusion-weighted MR imaging (DWI), disappeared. Reversible circumscribed cytotoxic oedema (CCO) of the splenium of the CC is a well-defined entity that is found to be associated with administration of antiepileptic drugs, alterations in therapy using arginin-vasopressin and metronidazole or infections with influenza and rotavirus. CCO of splenium of the CC is clearly visible on DWI, shows no enhancement after administration of contrast medium and is completely reversible in most cases.
authors.affiliation: Department of Pediatrics, State Clinical Center, Tulln, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Grühbaum
authors.forename: Hans
authors.initials: H
authors.lastname: Salzer
authors.forename: Christian
authors.initials: C
authors.lastname: Nasel
authors.forename: Isolde
authors.initials: I
authors.lastname: Lernbass
mesh_terms: D000293:Adolescent; D003337:Corpus Callosum / Q000473:pathology*; D004487:Edema / Q000473:pathology*; D005260:Female; D005499:Folliculitis / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D013752:Tetracycline / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D013752:Tetracycline