Recurrent acute stent thrombosis due to allergic reaction secondary to clopidogrel therapy.
Despite significant benefits including mortality advantage demonstrated with antiplatelet therapy in large clinical trials, the occurrence of adverse ischemic events, including stent thrombosis after percutaneous coronary intervention has been the challenging and devastating complication. Clopidogrel as a monotherapy, or more common in combination with aspirin, represents a cornerstone of modern pharmacotherapy in the invasive era. Although vigilance in maintenance of this dual antiplatelet treatment is mandatory, obligatory cessation of one of these agents can be observed in rare circumstances of adverse events. We describe a patient who developed recurrent acute stent thrombosis associated with clopidogrel-induced allergic reaction and discuss our therapeutic considerations.
Karabay
Can Yücel
CY
Department of Cardiology, Koşuyolu Heart & Research Hospital, Istanbul, Turkey.
Can
Mehmet Mustafa
MM
Tanboğa
Ibrahim Halil
IH
Ahmet
Güler
G
Bitigen
Atila
A
Serebruany
Victor
V
D000208:Acute Disease; D000328:Adult; D000077144:Clopidogrel; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012008:Recurrence; D015607:Stents; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine