title: Acquired platelet dysfunction in 109 patients from a tertiary care referral hospital.
abstract: BACKGROUND
  Acquired platelet function defects (PFDs) remain poorly characterized, underrecognized, and therefore understudied.
  
  
  METHODS
  Clinical and laboratory records of 109 patients with acquired PFDs diagnosed over 5 years were analyzed. Screening studies (platelet count, prothrombin time, activated partial thromboplastin time, and thrombin time), template bleeding time, platelet factor 3 (PF-3) availability test, light-transmission aggregometry, and further testing as indicated were performed.
  
  
  RESULTS
  64 patients had mild and 26 had major bleeding. In all, 15 were referred for preoperative testing, whereas 4 had thrombotic events. Causes and associations of PFDs were drug-induced (34), idiopathic (34), hematopoietic neoplasms (15; myeloma 4, Waldenstrom macroglobulinemia 2, chronic myeloid leukemia 4, essential thrombocythaemia 3, and primary myelofibrosis and chronic lymphocytic leukemia 1 each), chronic liver disease (4), postcardiac surgery (2), uremia (2), and thalassemia major (7). Miscellaneous disorders comprised the rest.
  
  
  CONCLUSIONS
  Acquired PFDs span a wide range of disease settings. Systematic, sequential laboratory testing identifies patterns of dysfunction, excludes inherited disorders, and streamlines management.
authors.affiliation: Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Sharma
authors.forename: Rakhee
authors.initials: R
authors.lastname: Kar
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhargava
authors.forename: Ravi
authors.initials: R
authors.lastname: Ranjan
authors.lastname: Pravas Chandra Mishra
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D001791:Blood Platelet Disorders / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011517:Prothrombin Time; D012017:Referral and Consultation; D013918:Thrombin Time