title: [Formula screening and optimizing for the dispersible tablets of breviscapine by orthogonal experiment].
abstract: OBJECTIVE
  To establish a suitable formulation for the dispersible tablets of brevisicapine.
  
  
  METHODS
  To prepare and optimize the breviscapine dispersible tablets by orthogonal experiment design using disintegration time as the index. The quality of breviscapine dispersible tablets was evaluated by the initial stability test.
  
  
  RESULTS
  The disintegration time of optimized prescription formulation was 89 s. L-HPC and CMS-Na were used by combining exterior and interior and the dissolution percent in vitro was obviously superior to the conventional tablets, and the quality of the dispersible tablets was very good in stability test.
  
  
  CONCLUSIONS
  The formulation screened out for the dispersible tablets of breviscapine is reasonable, stable and suitable for the production on a large scale.
authors.affiliation: Department of Pharmacy, Shandong University, Jinan 250012, China. dyanan1696@sina.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Huang
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry; D049919:Erigeron / Q000737:chemistry*; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005079:Excipients; D005419:Flavonoids; D013607:Tablets; C061097:breviscapine