title: Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum adiponectin in rats fed a high-fat diet.
abstract: The effect was examined of dietary sericin on the lipid and carbohydrate metabolism in rats fed with a high-fat diet. The rats were fed with a 20% beef tallow diet with or without sericin at the level of 4% for 5 weeks. The final body weight and white adipose tissue weight were unaffected by dietary manipulation. The consumption of sericin significantly reduced the serum levels of triglyceride, cholesterol, phospholipids and free fatty acids. Serum very-low-density lipoprotein (VLDL)-triglyceride, VLDL-cholesterol, low-density lipoprotein (LDL)-cholesterol and LDL-phospholipids were also significantly reduced by the sericin intake. Liver triglyceride and the activities of glucose 6-phosphate dehydrogenase and malic enzyme, the lipogenic enzymes, were also reduced by the sericin intake. Dietary sericin caused a marked elevation in serum adiponectin. The consumption of sericin suppressed the increases in plasma glucose and insulin levels after an intraperitoneal glucose injection. These results imply the usefulness of sericin for improving the lipid and carbohydrate metabolism in rats fed on a high-fat diet.
authors.affiliation: Faculty of Human Life Sciences, Fuji Women's University, Ishikari, Japan. yokazaki@fujijoshi.ac.jp
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Shoko
authors.initials: S
authors.lastname: Kakehi
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Xu
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Tsujimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000284:Administration, Oral; D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects*; D004044:Dietary Proteins / Q000494:pharmacology*; D004435:Eating; D005947:Glucose / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D047030:Sericins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D052242:Adiponectin; D004041:Dietary Fats; D004044:Dietary Proteins; D008055:Lipids; D047030:Sericins; D005947:Glucose