Enterovirus 71 infection of monocytes with antibody-dependent enhancement.
Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and young children. The most vulnerable age for fatal infection is 6 to 11 months. This is associated with the coincident decline in maternal antibodies. The current report describes our finding that EV71 can infect human peripheral blood monocytes. We were able to show that EV71 infection is enhanced in the monocytic cell line THP-1 by the presence of subneutralizing concentrations of anti-EV71 antibodies. We also found that antibody-dependent enhancement (ADE) is mediated in part by Fcγ receptors. These observations support the concept that ADE augments the infectivity of EV71 for human monocytes and contributes to the age-dependent pathogenesis of EV71-induced disease. The ADE phenomenon must be considered during the development of an EV71 vaccine.
Wang
Shih-Min
SM
Department of Pediatrics, College of Medicine, National Cheng Kung University and Hospital, 138 Sheng Li Road, Tainan, Taiwan.
Chen
I-Chun
IC
Su
Ling-Yao
LY
Huang
Kao-Jean
KJ
Lei
Huan-Yao
HY
Liu
Ching-Chuan
CC
D000328:Adult; D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D019067:Antibody-Dependent Enhancement; D002460:Cell Line; D002675:Child, Preschool; D029821:Enterovirus A, Human / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D009000:Monocytes / Q000821:virology*; D017452:Receptors, IgG / Q000276:immunology
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D017452:Receptors, IgG