Small solid pseudopapillary tumor of the pancreas in a 32-year-old man: report of a case.
A solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm that mainly occurs in young women. We herein report the case of a small SPT arising from the head of the pancreas in an asymptomatic 32-year-old man, plus a literature review of this tumor. A 32-year-old man was admitted to our department at Kumamoto University Hospital for the evaluation of a pancreatic mass. The tumor had central necrosis, which was poorly perfused on contrast-enhanced computed tomography (CT) and which had a high intensity on T2-weighted magnetic resonance imaging (MRI). Histology revealed the lesion to be a solid pseudopapillary tumor of the pancreas, with the characteristic pseudopapilla formation and central degeneration. However, no capsule formation was observed. The tumor was positive for CD56, CD10, alpha1-antitrypsin, alpha1-antichymotrypsin, beta-catenin, and progesterone receptor. However, the tumor was negative for pancreatic hormones, chromogranin-A, carcinoembryonic antigen, and carbohydrate antigen 19-9. We diagnosed the patient to have an SPT based on these histological findings. Small-sized solid pseudopapillary tumors of the pancreas are being increasingly recognized because of the recent advances in CT and MRI. We should also consider SPT even if it occurs in a male when the tumor contains necrosis-suspected areas which are poorly perfused on contrast-enhanced CT with a high intensity on T2-weighted MRI.
Mima
Kosuke
K
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
Hirota
Masahiko
M
Abe
Shinya
S
Iwatsuki
Masaaki
M
Imamura
Hiroshi
H
Tsuruzoe
Shu
S
Chikamoto
Akira
A
Tanaka
Hiroshi
H
Takamori
Hiroshi
H
Kanemitsu
Keiichiro
K
Tagami
Hirofumi
H
Honda
Yumi
Y
Iyama
Kenichi
K
Baba
Hideo
H
D000328:Adult; D019002:CD56 Antigen; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008297:Male; D015260:Neprilysin; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011379:Prognosis; D011980:Receptors, Progesterone; D014057:Tomography, X-Ray Computed; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D051176:beta Catenin
D019002:CD56 Antigen; D011980:Receptors, Progesterone; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D051176:beta Catenin; D015260:Neprilysin