title: Transient anterior corneal deposits in a human immunodeficiency virus-positive patient.
abstract: OBJECTIVE
  To report findings of pigmented anterior corneal deposits in a human immunodeficiency virus-positive patient.
  
  
  METHODS
  Case report. A 49-year-old human immunodeficiency virus-positive patient was examined after the appearance of pigmented corneal deposits. Slit-lamp biomicroscopy, fundus photography, and laser-scanning in vivo confocal microscopy were performed to visually document the ocular condition.
  
  
  RESULTS
  The patient had a history of Mycobacterium avium infection and was suspected to have recovery uveitis from a cytomegalovirus infection. Small, rounded, light brown-colored deposits were distributed across the anterior cornea from limbus to limbus, bilaterally. In vivo confocal microscopy revealed the deposits to be confined to the basal epithelium and Bowman layer, whereas the posterior stroma, Descemet membrane, and the endothelium appeared normal. Systemic steroid treatment was administered, and 2 weeks later, the deposits had vanished on slit-lamp examination, whereas remnants were observed at the microscopic level.
  
  
  CONCLUSIONS
  The deposits were unusual for their anterior corneal location and pancorneal distribution. The response to systemic steroid treatment remains unexplained and illustrates the complexity of the underlying conditions, their treatment, and the associated pathways of ocular manifestation.
authors.affiliation: Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: Beatrice Bourghardt
authors.initials: BB
authors.lastname: Peebo
authors.forename: Per
authors.initials: P
authors.lastname: Fagerholm
authors.forename: Neil
authors.initials: N
authors.lastname: Lagali
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D050541:Bowman Membrane / Q000473:pathology; D003316:Corneal Diseases / Q000473:pathology* / Q000821:virology*; D003907:Dexamethasone / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage; D006679:HIV Seropositivity / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008499:Medical Records; D018613:Microscopy, Confocal; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids; D003907:Dexamethasone; D015774:Ganciclovir