title: Successful treatment of angiofibromata of tuberous sclerosis complex with rapamycin.
abstract: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome manifesting as hamartomatous growths in multiple organs. We present two cases of patients with TSC and associated facial angiofibromata treated with topical and oral rapamycin and discuss the role for rapamycin in the treatment of these disfiguring lesions. Our patients demonstrated decreased numbers of angiofibromata and less redness with this treatment. This is the first published report on the use of topical rapamycin for the treatment of angiofibromata.
authors.affiliation: Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Kaufman McNamara
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Curtis
authors.forename: Alan B
authors.initials: AB
authors.lastname: Fleischer
mesh_terms: D000328:Adult; D018322:Angiofibroma / Q000150:complications / Q000188:drug therapy*; D002648:Child; D005153:Facial Neoplasms / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D020123:Sirolimus / Q000627:therapeutic use*; D014402:Tuberous Sclerosis / Q000150:complications*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus