title: In vitro modulation of macrophage functions by 1,1-dimethylhydrazine (UDMH): Possible mechanism for UDMH-induced immuno-enhancement.
abstract: The in vitro effects of 1,1-dimethylhydrazine (UDMH) on prostaglandin E(2) (PGE(2)) synthesis, chemiluminescence, phagocytosis, microbicidal activity and chemotaxis in murine enriched-macrophage populations were evaluated. PGE(2) synthesis by resident peritoneal macrophages and chemiluminescence by activated macrophages were markedly suppressed in the presence of UDMH; phagocytosis and microbicidal activity were slightly to moderately suppressed, and chemotaxis was not affected. Two of these functions (PGE(2) synthesis and chemiluminescence) reflect macrophage immunoregulatory properties, and the UDMH-induced abrogation of these functions may be related to the previously reported immuno-enhancing effects of UDMH.
authors.affiliation: Department of Veterinary Pathobiology, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Tarr
authors.forename: R G
authors.initials: RG
authors.lastname: Olsen
authors.forename: B L
authors.initials: BL
authors.lastname: Bowen
authors.forename: R H
authors.initials: RH
authors.lastname: Fertel