title: AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz.
abstract: In the absence of treatment, most HIV-1-infected humans develop AIDS. However, a minority are long-term nonprogressors, and resistance is associated with the presence of particular HLA-B*27/B*57 molecules. In contrast, most HIV-1-infected chimpanzees do not contract AIDS. In comparison with humans, chimpanzees experienced an ancient selective sweep affecting the MHC class I repertoire. We have determined the peptide-binding properties of frequent chimpanzee MHC class I molecules, and show that, like HLA-B*27/B*57, they target similar conserved areas of HIV-1/SIV(cpz). In addition, many animals appear to possess multiple molecules targeting various conserved areas of the HIV-1/SIV(cpz) Gag protein, a quantitative aspect of the immune response that may further minimize the chance of viral escape. The functional characteristics of the contemporary chimpanzee MHC repertoire suggest that the selective sweep was caused by a lentiviral pandemic.
authors.affiliation: Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.
authors.forename: Natasja G
authors.initials: NG
authors.lastname: de Groot
authors.forename: Corrine M C
authors.initials: CM
authors.lastname: Heijmans
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Zoet
authors.forename: Arnoud H
authors.initials: AH
authors.lastname: de Ru
authors.forename: Frank A
authors.initials: FA
authors.lastname: Verreck
authors.forename: Peter A
authors.initials: PA
authors.lastname: van Veelen
authors.forename: Jan W
authors.initials: JW
authors.lastname: Drijfhout
authors.forename: Gaby G M
authors.initials: GG
authors.lastname: Doxiadis
authors.forename: Edmond J
authors.initials: EJ
authors.lastname: Remarque
authors.forename: Ilias I N
authors.initials: II
authors.lastname: Doxiadis
authors.forename: Jon J
authors.initials: JJ
authors.lastname: van Rood
authors.forename: Frits
authors.initials: F
authors.lastname: Koning
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Bontrop
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D017124:Conserved Sequence; D015683:Gene Products, gag / Q000235:genetics / Q000378:metabolism; D005805:Genes, MHC Class I; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics* / Q000276:immunology*; D011485:Protein Binding; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000276:immunology*; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015683:Gene Products, gag; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C103707:HLA-B57 antigen; D015395:Histocompatibility Antigens Class I