[Lymphocyte GRK2 expression of the very elderly with chronic heart failure].
OBJECTIVE
To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).


METHODS
16 elderly patients with chronic heart failure were divided into 2 groups as following: EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.


RESULTS
Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.


CONCLUSIONS
Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.
Gao
Wen-qian
WQ
Department 1 of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China. gwqbj08@sina.com
Ma
Jin-ling
JL
Han
Chun-guang
CG
Wang
Qiong
Q
Zhu
Ping
P
Yang
Ting-shu
TS
D000369:Aged, 80 and over; D002908:Chronic Disease; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000235:genetics / Q000378:metabolism*; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013318:Stroke Volume / Q000502:physiology*
D012333:RNA, Messenger; C496567:GRK2 protein, human; D054769:G-Protein-Coupled Receptor Kinase 2