title: [Molecular mechanisms of genetic damages of the myocardium in cardiomyopathy].
abstract: The review highlighted problems of reorganization of myocardical contractile and cytoskeletal proteins in cardiomyopathy (CM). The role of the genetic factors coding contractile proteins, proteins of thin and thick filaments, and also extracellular matrix proteins in processes of formation and development of hypertrophic (HCM) and dilated (DCM) cardiomyopathy are analyzed. The mechanisms responsible for the changes in cardiac proteins on regulation involved into force generation, its transfer, recycling ATP, impairments in transmembranal signals, that finally lead to cardiac cell dysfunction determining various manifestations of CM are considered.
authors.forename: A G
authors.initials: AG
authors.lastname: Gasanov
authors.forename: T V
authors.initials: TV
authors.lastname: Bershova
authors.forename: E N
authors.initials: EN
authors.lastname: Basargina
authors.forename: M I
authors.initials: MI
authors.lastname: Bakanov
mesh_terms: D009202:Cardiomyopathies / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D003285:Contractile Proteins / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D012518:Sarcomeres / Q000235:genetics / Q000378:metabolism
chemical_list: D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D016326:Extracellular Matrix Proteins