title: Detection of exaggerated blood pressure response using laboratory of physical science protocol and risk of future hypertension.
abstract: OBJECTIVE
  To assess the usefulness of the Laboratory of Physical Science (LOPS) protocol for detecting exaggerated blood pressure (BP) response as a risk factor for future hypertension when controlling for work and personal factors.
  
  
  METHODS
  Subjects were 815 healthy normotensive men (mean age, 43.1 ± 6.76 yr; range, 29-64 yr) who participated in the LOPS protocol, a graded 4-stage exercise test undertaken for the measurement of 40-70% of maximum oxygen consumption. A hypertensive response was defined as systolic blood pressure (SBP) of 250 mmHg or diastolic blood pressure (DBP) of 120 mmHg during the exercise test.
  
  
  RESULTS
  New-onset hypertension or the initiation of antihypertensive drug treatment had occurred in 108 men (13.3%) after 7 yr of follow-up. Cox proportional survival analysis revealed significantly increased risks of developing hypertension were associated with exaggerated BP response to exercise (hazard ratio, 2.3; 95% confidence interval, 1.4-3.7) and higher frequency of business trips (hazard ratio, 1.7; 95% confidence interval, 1.2-2.5) after multivariable adjustments for work and personal-related risk factors.
  
  
  CONCLUSIONS
  These results suggest that the LOPS protocol is effective for detecting exaggerated BP response as a risk factor for future hypertension when controlling for work and personal-related risk factors. Exaggerated BP response to exercise and higher frequency of business trips are risk factors for developing future hypertension.
authors.affiliation: Kagoshima Occupational Environmental Health Center, Toukai-cho, Kagoshima city, Kagoshima, Japan. odahara@mbr.nifty.com
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Odahara
authors.forename: Masataka
authors.initials: M
authors.lastname: Irokawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Karasawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D004651:Employment; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D016019:Survival Analysis; D014195:Travel