title: Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: a case-control study.
abstract: Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels by ELISA in 28 patients with MTLE and 28 healthy controls and found that patients showed significantly elevated S100B levels compared with healthy controls (P=0.018). Moreover, S100B levels were significantly higher in female patients than those in male patients (P=0.027). These results suggest that S100B may be a biomarker of MTLE.
authors: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors: Changfeng
authors: C
authors: Lu
authors: Jun
authors: J
authors: Li
authors: Wei
authors: W
authors: Sun
authors: Lei
authors: L
authors: Feng
authors: Liping
authors: L
authors: Li
authors: Aihua
authors: A
authors: Liu
authors: Junjie
authors: J
authors: Li
authors: Wei
authors: W
authors: Mao
authors: Hua
authors: H
authors: Wei
authors: Lehong
authors: L
authors: Gao
authors: Xiating
authors: X
authors: Zhang
authors: Zhaoyang
authors: Z
authors: Huang
authors: Xianghong
authors: X
authors: Meng
authors: Yuping
authors: Y
authors: Wang
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D044466:Asian People / Q000208:ethnology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012598:Sclerosis / Q000150:complications / Q000473:pathology; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human