title: Synthesis and biological property of some novel 1,3,4-oxadiazoles.
abstract: A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1'-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity.
authors: Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India.
authors: G C
authors: GC
authors: Ramaprasad
authors: Balakrishna
authors: B
authors: Kalluraya
authors: B Sunil
authors: BS
authors: Kumar
authors: Ravindra K
authors: RK
authors: Hunnur
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D005260:Female; D005658:Fungi / Q000187:drug effects; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D010069:Oxadiazoles