Molecular imaging of the dopamine transporter.
The dopamine transporter (DAT) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. Several radioligands are available for DAT imaging with SPECT and PET. This review summarizes the main SPECT and PET radioligands and the main applications of DAT imaging in neuropsychiatric disorders.
Varrone
Andrea
A
Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden. andrea.varrone@ki.se
Halldin
Christer
C
D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D004298:Dopamine / Q000172:deficiency; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D010300:Parkinson Disease / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy
D015415:Biomarkers; D050483:Dopamine Plasma Membrane Transport Proteins; D004298:Dopamine