title: [Immune response in patients with HCV infection on the south of western Siberia].
abstract: The aim of the study was to investigate the features of immune response in patients with HCV infection on the South of Western Siberia.
  
  
  METHODS
  The 130 patients with different genotips of HCV infection were investigated (95 men and 35 women).
  
  
  RESULTS
  On the territory of the South of Western Siberia the 1 and 3 genotips of HCV infection were present especially in young men and women and 1b subtype was dominated. In patients with 1 and 3 genotips of HCV infection was occurred the massive inflammatory response with intensive necrotic proinflammatory cytokins damages of the liver tissue and high cirrotic occurring in young age.
authors: V V
authors: VV
authors: P'iannikov
authors: V A
authors: VA
authors: Akhmedov
authors: V V
authors: VV
authors: Gorchakov
authors: T V
authors: TV
authors: Vas'kina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D005260:Female; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000096:biosynthesis; D012800:Siberia; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D019014:fas Receptor / Q000096:biosynthesis
chemical_list: D017252:CD3 Complex; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D015847:Interleukin-4; D007371:Interferon-gamma