title: Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC cohort.
abstract: BACKGROUND
  A considerable local variability in the rate of bronchopulmonary dysplasia (BPD) has been recorded previously.
  
  
  OBJECTIVE
  The objectives of the present study were to describe regional differences in the rate of BPD in very preterm neonates from a European population-based cohort and to further delineate risk factors.
  
  
  METHODS
  4,185 survivors to 36 weeks' postmenstrual age of 4,984 live-born infants born at 24+0-31+6 weeks' gestation in 2003 (the MOSAIC cohort) in 10 European regions were enrolled using predefined structured questionnaires.
  
  
  RESULTS
  Overall median gestational age of preterms without BPD was 30 weeks (range 23-31), median birth weight 1,320 g (range 490-3,150) compared with 27 weeks (23-31) and 900 g (370-2,460) in those with BPD. The region-specific crude rate of BPD ranged from 10.2% (Italian region) to 24.8% (UK Northern region). Maternal hypertension, immaturity, male gender, small for gestational age, Apgar <7 and region of care were associated with an increased incidence of BPD on multivariate analysis.
  
  
  CONCLUSIONS
  A wide variability of BPD between European regions may be explained by different local practices; the strongest association however was with degree of immaturity.
authors: Pediatric University Hospital, University of Saarland, Homburg, Germany. kilgor@uks.eu
authors: Ludwig
authors: L
authors: Gortner
authors: Björn
authors: B
authors: Misselwitz
authors: David
authors: D
authors: Milligan
authors: Jennifer
authors: J
authors: Zeitlin
authors: Louis
authors: L
authors: Kollée
authors: Klaus
authors: K
authors: Boerch
authors: Rocco
authors: R
authors: Agostino
authors: Patrick
authors: P
authors: Van Reempts
authors: Jean-Louis
authors: JL
authors: Chabernaud
authors: Gérard
authors: G
authors: Bréart
authors: Emile
authors: E
authors: Papiernik
authors: Pierre-Henri
authors: PH
authors: Jarreau
authors: Manuel
authors: M
authors: Carrapato
authors: Janusz
authors: J
authors: Gadzinowski
authors: Elizabeth
authors: E
authors: Draper
mesh_terms: D001034:Apgar Score; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D015999:Multivariate Analysis; D011247:Pregnancy; D011446:Prospective Studies; D012044:Regression Analysis