title: Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells.
abstract: Efforts to identify potent small molecule inhibitors of Helicobacter pylori led to the evaluation of 23 3',4',5'-trimethoxychalcone analogues. Some of the compounds displayed potent antibacterial activity against H. pylori. Three most active and selective compounds 1, 7, and 13 also showed the bactericide activity against the reference as well as multidrug-resistant strains of H. pylori. Additionally, the aforementioned three compounds potentially inhibited the H. pylori adhesion and invasion to human gastric epithelial (AGS) cells. Furthermore, these selective compounds inhibited the H. pylori-induced gastric inflammation by reduced inflammatory mediator's nuclear factor kappa B activation, and the secretion of interleukin-8.
authors: Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan, ROC.
authors: Chih-Ho
authors: CH
authors: Lai
authors: Yerra Koteswara
authors: YK
authors: Rao
authors: Shih-Hua
authors: SH
authors: Fang
authors: Yu-Ting
authors: YT
authors: Sing
authors: Yew-Min
authors: YM
authors: Tzeng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology; D005756:Gastritis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology; D016328:NF-kappa B / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D047188:Chalcones; D016209:Interleukin-8; D016328:NF-kappa B; C003702:metochalcone