title: Correlation between imaging features and epithelial cell proliferation in keratocystic odontogenic tumour.
abstract: OBJECTIVE
  this study was undertaken to investigate the relationship between radiographic appearance and epithelial cell proliferations in keratocystic odontogenic tumours (KCOTs).
  
  
  METHODS
  a retrospective radiographic analysis was performed on 284 cases of KCOT to gain insight into the radiographic characteristics. Expression of Ki-67 in 30 of the 284 cases was detected by the labelled streptavidin-biotin (LSAB) method and evaluated by an image analysis system.
  
  
  RESULTS
  the radiographic presentation of KCOT was divided into four types: unilocular, multilocular, multiple and naevoid basal cell carcinoma syndrome (NBCCS). The expression of Ki-67 in NBCCS was significantly different from the solitary and multiple KCOTs (P = 0.018, 0.002). In multilocular KCOTs it was also significantly different from the unilocular and syndrome-associated lesions (P = 0.000). In contrast, no significant differences were observed between the solitary and multiple lesions (P = 0.220).
  
  
  CONCLUSIONS
  a high correlation exists in KCOT between its biological behaviour and imaging features. The solitary KCOT seems less biologically aggressive and it should be classified as a cyst rather than a tumour. This means that more than half of KCOTs manifest themselves as ordinary cysts.
authors: Department of Oral Radiology, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P.R.China. wanghu200108@163.com
authors: K
authors: K
authors: Ba
authors: X
authors: X
authors: Li
authors: H
authors: H
authors: Wang
authors: Y
authors: Y
authors: Liu
authors: G
authors: G
authors: Zheng
authors: Z
authors: Z
authors: Yang
authors: M
authors: M
authors: Li
authors: K
authors: K
authors: Shimizutani
authors: T
authors: T
authors: Koseki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D009808:Odontogenic Tumors / Q000145:classification / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D011862:Radiography, Panoramic; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen; D007633:Keratins