title: Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes.
abstract: OBJECTIVE
  Adipocyte fatty acid-binding protein (FABP4) plasma levels are higher in type 2 diabetes (T2D). Endothelial dysfunction is also common in T2D. We have investigated the relationship between circulating FABP4 levels and endothelial function in diabetic patients.
  
  
  METHODS
  In 257 patients (105 diabetic and 152 non-diabetic) at increased risk of cardiovascular disease, we measured circulating FABP4, reactive hyperemia index (RHI) by peripheral artery tonometry, intima-media thickness, and biomarkers of inflammation, oxidation and endothelial function.
  
  
  RESULTS
  In T2D subjects, FABP4 was negatively associated with endothelial function, as measured by RHI (r=-0.226, P=0.05). In a stepwise multivariate linear regression model, FABP4 was a predictor of RHI in T2D patients (P=0.04).
  
  
  CONCLUSIONS
  Circulating levels of FABP4 are inversely associated with endothelial function in T2D patients, as measured by RHI. We suggest a direct effect of plasma FABP4 on the vascular endothelium in those with T2D.
authors: Research Unit on Lipids and Atherosclerosis, Universitat Rovira i Virgili, Internal Medicine Department, Sant Joan University Hospital, IISPV, CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Reus, Spain.
authors: Gemma
authors: G
authors: Aragonès
authors: Raimon
authors: R
authors: Ferré
authors: Iolanda
authors: I
authors: Lázaro
authors: Anna
authors: A
authors: Cabré
authors: Núria
authors: N
authors: Plana
authors: Jordi
authors: J
authors: Merino
authors: Mercedes
authors: M
authors: Heras
authors: Josefa
authors: J
authors: Girona
authors: Lluís
authors: L
authors: Masana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000473:pathology; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000737:chemistry; D012044:Regression Analysis; D012306:Risk
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D010100:Oxygen