title: Is there any possible genotoxic effect in exfoliated bladder cells of rat under the exposure of 1800 MHz GSM-like modulated radio frequency radiation (RFR)?
abstract: People are exposed to many carcinogenic and mutagenic chemicals in their everyday lives. These include antineoplastic drugs, Polycyclic aromatic hydrocarbons (PAH)s, aromatic amines, nitrosamines, metals, and electromagnetic radiation. Based on the state of knowledge acquired during the last 50 years of research on possible biological effects of electromagnetic fields (EMF), the majority of the scientific community is convinced that exposure to EMF below the existing security limits does not cause a risk to the health of the general public. However, this position is questioned by others, who are of the opinion that the available research data are contradictory or inconsistent and, therefore, unreliable. In this study, we aimed to investigate if there is any effect of 1800 MHz GSM modulated radio frequency radiation (RFR) on the number of micronucleus in exfoliated bladder cells of rat which will be informative about the genotoxic damage. Exposure period was 20 min/day, 5 days/week during a month. Six female Wistar rats were used for two groups: Group I (n=6): controls; Group II (n=6): 1.8 GHz exposed animals. 1800 MHz RFR did not showed a significant MN frequencies in rat bladder cells when compared with the control group (p>0.05). 1800 MHz RFR-exposed animals did not produce any genotoxic effect when compared with the control group ( p>0.05). Kinetic studies are important for any biomarker, especially those in which tissue differentiation and maturation processes will heavily influence the time between induction of damage and collection of damaged cells for micronucleus analysis.
authors: Medical Faculty of Gazi University, Laboratory Animal Breeding and Experimental Research Center, Ankara, Turkey. neslihan.gurbuz@gazi.edu.tr
authors: Neslihan
authors: N
authors: Gurbuz
authors: Bahriye
authors: B
authors: Sirav
authors: Hilal Uslu
authors: HU
authors: Yuvaci
authors: Nilgun
authors: N
authors: Turhan
authors: Zafer Kutay
authors: ZK
authors: Coskun
authors: Nesrin
authors: N
authors: Seyhan
mesh_terms: D000818:Animals; D005260:Female; D015162:Micronucleus Tests / Q000379:methods*; D011846:Radio Waves / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000166:cytology* / Q000528:radiation effects*