Exertional heatstroke: early recognition and outcome with aggressive combined cooling--a 12-year experience.
OBJECTIVE
To determine the clinical outcomes of an aggressive combined cooling technique for exertional heatstroke in Thailand.


METHODS
We analyzed patients who were diagnosed with exertional heatstroke between 1995 and 2007. Outcomes were assessed both in hospital and at 3 months follow-up.


RESULTS
Twenty-eight cases of exertional heatstroke presented to Phramongkutklao Army Hospital over 12 years. All patients developed multiorgan dysfunction and encephalopathy. Twenty-four cases had acute renal failure, 7 of whom required dialysis. Disseminated intravascular coagulation (DIC) was detected in 9 patients (32.1%). In-hospital mortality was 7.1%. Most survivors recovered with nearly normal organ function. However, 9 exhibited prolonged neurologic dysfunction and 2 had chronic renal dysfunction requiring hemodialysis. At 3-month follow-up, neurologic and renal dysfunction in those patients persisted. Higher serum prothrombin time and DIC correlated to fatality. The patients whose core body temperature achieved 38 degrees C within 3 hours revealed a significantly lower DIC and twice as low in the frequency of poor outcome than the patients cooled longer than 3 hours to reduce core body temperature to 38 degrees C.


CONCLUSIONS
Despite early recognition and aggressive combined cooling, exertional heatstroke remains associated with multiorgan dysfunction. However, our 7.1% in-hospital mortality rate was low compared to previous studies. Early diagnosis and prompt treatment are critical.
Sithinamsuwan
Pasiri
P
Division of Neurology, Department of Medicine, Phramongkutklao Army Hospital and Medical College, Bangkok, 10400, Thailand.
Piyavechviratana
Kunchit
K
Kitthaweesin
Thitisak
T
Chusri
Watcharapong
W
Orrawanhanothai
Patima
P
Wongsa
Adisorn
A
Wattanathum
Anan
A
Chinvarun
Yotin
Y
Nidhinandana
Samart
S
Satirapoj
Bancha
B
Supasyndh
Ouppatham
O
Sriswasdi
Chantrapa
C
Prayoonwiwat
Wichai
W
D000328:Adult; D001831:Body Temperature; D016009:Chi-Square Distribution; D003080:Cold Temperature; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D018883:Heat Stroke / Q000150:complications / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D017052:Hospital Mortality; D006772:Hospitals, Military; D006801:Humans; D008297:Male; D008887:Military Medicine / Q000379:methods*; D005082:Physical Exertion; D018709:Statistics, Nonparametric; D013785:Thailand; D016896:Treatment Outcome