title: Efficient "one-pot" synthesis of novel 3-azabicyclic spiro-1',2',4'-triazolidin-3'-thiones catalyzed by potassium superoxide and their in vitro antibacterial and antifungal activities.
abstract: A new series of novel 3-azabicyclic spiro 1',2',4'-triazolidin-3'-thiones 15-21 catalyzed by potassium superoxide under microwave irradiation have been synthesized and studied for their in vitro microbiological evaluation on clinically isolated bacterial strains namely Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeuroginosa and fungal strains namely Aspergillus niger, Candida albicans, Candida 6 and Candida 51. Results of the in vitro microbiological evaluation of the synthesized compounds are discussed.
authors: Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Tamil Nadu, India.
authors: V
authors: V
authors: Kanagarajan
authors: M
authors: M
authors: Gopalakrishnan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013871:Thiones; D013481:Superoxides; C039316:potassium superoxide