title: Partial area of cholesterol in monounsaturated diacylphosphatidylcholine bilayers.
abstract: The influence of cholesterol on the structural parameters of phosphatidylcholine bilayers is studied by small-angle neutron scattering on unilamellar liposomes. Monounsaturated diacylphosphatidylcholines diCn:1PC with the length of acyl chains n=14, 18 and 22 carbons are used. We confirm that the bilayer thickness increases with increasing concentration of cholesterol for all studied diCn:1PCs. However, partial areas per diCn:1PC and cholesterol molecule on lipid-water interface are found not to depend of cholesterol concentration. The partial area per cholesterol molecule is 0.24nm². In addition, the partial area per diC18:1PC is larger than that for diC14:1PC and diC22:1PC.
authors: Department of Physical Chemistry of Drugs, Comenius University in Bratislava, Slovakia. gallova@fpharm.uniba.sk
authors: J
authors: J
authors: Gallová
authors: D
authors: D
authors: Uhríková
authors: N
authors: N
authors: Kučerka
authors: J
authors: J
authors: Teixeira
authors: P
authors: P
authors: Balgavý
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D033363:Neutron Diffraction; D010713:Phosphatidylcholines / Q000737:chemistry*; D053838:Scattering, Small Angle; D053835:Unilamellar Liposomes / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D053835:Unilamellar Liposomes; D015060:1,2-Dipalmitoylphosphatidylcholine; D002784:Cholesterol; C028694:1-palmitoyl-2-oleoylphosphatidylcholine