title: Non-ST-segment elevation myocardial infarction in a patient with essential thrombocythemia treated with glycoprotein IIb/IIIa inhibitor: a case report.
abstract: Essential thrombocythemia (ET) can cause systemic vascular thrombosis but rarely cause obstruction of coronary arteries or acute myocardial infarction (MI). Treatment of acute MI in patients with ET may be a problem due to the important role of platelets in the pathogenesis of infarction. In this report, a 63-year-old man presented with acute chest pain and a greatly increased platelet count. The patient was successfully treated with intravenous tirofiban, a glycoprotein IIb/IIIa receptor blocker. Essential thrombocythemia was diagnosed based on bone marrow findings, clinical presentation, and laboratory analysis. Thrombocythemia had been controlled with hydroxyurea.
authors: Heart Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors: Zhiyong
authors: Z
authors: Zhang
authors: Xinhong
authors: X
authors: Wan
authors: Yuanyuan
authors: Y
authors: Liu
authors: Xiangmin
authors: X
authors: Lin
authors: Zhuhua
authors: Z
authors: Ni
authors: Xinchun
authors: X
authors: Yang
authors: Lin
authors: L
authors: Zhang
mesh_terms: D004562:Electrocardiography; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D010976:Platelet Count; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D000077466:Tirofiban; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D004791:Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014443:Tyrosine; D000077466:Tirofiban; D006918:Hydroxyurea