title: Anti-tubercular agents. Part 5: synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners.
abstract: In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 microg/mL) is also discussed.
authors: Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 607, India. ahmedkamal@iict.res.in
authors: Ahmed
authors: A
authors: Kamal
authors: Rajesh V C R N C
authors: RV
authors: Shetti
authors: Shaik
authors: S
authors: Azeeza
authors: S Kaleem
authors: SK
authors: Ahmed
authors: P
authors: P
authors: Swapna
authors: A Malla
authors: AM
authors: Reddy
authors: Inshad Ali
authors: IA
authors: Khan
authors: Sandeep
authors: S
authors: Sharma
authors: Sheikh Tasduq
authors: ST
authors: Abdullah
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D001581:Benzothiadiazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005658:Fungi / Q000187:drug effects; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D001581:Benzothiadiazines