A novel effector protein modulates response regulator activity without altering phosphorylation.
Genes positively regulated by the global transcriptional response regulator CtrA are not expressed during a life cycle stage of Caulobacter crescentus when the regulator is activated by phosphorylation. Gora et al. (2010), in this issue of Molecular Cell, have discovered a novel effector protein that prevents activation but not repression by the regulator without altering its phosphorylation.
Curtis
Patrick D
PD
Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Brun
Yves V
YV