[Expression of activating and inhibitory receptors on peripheral blood natural killer cell subsets of women with reproductive failures].
It is now apparent that immunologic implantation failure and recurrent abortions are more than likely mediated through activation of natural killer (NK) cells. The NK cell activity is mediated by a balance between activating and inhibitory receptors upon recognition of MHC class I molecules. In this study, we investigated by flow cytometry the expression of activating and inhibitory receptors on NK cells of women with reproductive failures- recurrent spontaneous abortion (RSA) and implantation failures (IF). In women with implantation failures CD56+CD16+ NK cell subset was significantly increased (p = 0.017) and CD158a expressing NK cells was significantly decreased (p = 0.027). CD161-activating receptor expressing CD56+ NK cells were significantly decreased in women with RSA (p = 0.033). These data further support an imbalance in NK cell subsets in women with reproductive failures.
Baltadzheiva
D
D
Penkova
K
K
Stamenov
G
G
Dimitrova
D
D
Michailova
A
A
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D019002:CD56 Antigen / Q000276:immunology; D010064:Embryo Implantation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000276:immunology; D011247:Pregnancy; D017452:Receptors, IgG / Q000276:immunology; D054342:Receptors, KIR2DL1 / Q000276:immunology
D019002:CD56 Antigen; D055651:NK Cell Lectin-Like Receptor Subfamily B; D017452:Receptors, IgG; D054342:Receptors, KIR2DL1