A decade of the sperm-washing programme: where are we now?
Since 1999, we have treated HIV-positive men with sperm washing as part of a risk-reduction programme with a year-on-year increase in total infectious cycles performed to over 200 in 2008. Four hundred and thirty nine cycles of IUI, 114 cycles of IVF and 117 cycles of ICSI have been performed in HIV positive men over the decade and of the 259 couples treated, a pregnancy rate and ongoing pregnancy rate per couple of 45.4% and 36.3% have been achieved with over 100 children born with no seroconversions. We outline the continued importance of such risk-reduction measures with 9.7% of samples from men with 'stable' disease on anti-retroviral treatment and undetectable viral load demonstrating detectable viral particles in seminal fluid and discuss measures to improve outcome in this patient group.
Nicopoullos
James D M
JD
Chelsea & Westminster Assisted Conception Unit, London, UK. jnicopoullos@aol.com
Almeida
Paula
P
Vourliotis
Maria
M
Goulding
Rebecca
R
Gilling-Smith
Carole
C
D000328:Adult; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D005307:Fertilization in Vitro; D006679:HIV Seropositivity / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D013094:Spermatozoa; D016896:Treatment Outcome; D019562:Viral Load