title: A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han.
abstract: MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) in pre-miRNA may be biomarkers for biomedical applications. In this study, we performed a genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility in a case-control study. We found that the homozygote CC of this SNP increased the risk of ESCC compared with the homozygote TT and the risk was more evident among smokers than non-smokers. Therefore, this functional SNP may be a biomarker for ESCC outcome.
authors: Department of Basic Medicine, Third Military Medical University, Chongqing, PR China.
authors: Kai
authors: K
authors: Wang
authors: Hong
authors: H
authors: Guo
authors: Huamei
authors: H
authors: Hu
authors: Gang
authors: G
authors: Xiong
authors: Xingying
authors: X
authors: Guan
authors: Juan
authors: J
authors: Li
authors: Xueqing
authors: X
authors: Xu
authors: Kang
authors: K
authors: Yang
authors: Yun
authors: Y
authors: Bai
mesh_terms: D000368:Aged; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged
chemical_list: D017931:DNA Primers; C542543:MIRN196 microRNA, human; D035683:MicroRNAs