title: A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC).
abstract: BACKGROUND
  Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk.
  
  
  OBJECTIVE
  To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3.
  
  
  METHODS
  This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC).
  
  
  RESULTS
  In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m² had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001).
  
  
  CONCLUSIONS
  Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
authors: Nuffield Department of Clinical Medicine, University of Oxford, UK. francesca.crowe@ceu.ox.ac.uk
authors: Francesca L
authors: FL
authors: Crowe
authors: Timothy J
authors: TJ
authors: Key
authors: Naomi E
authors: NE
authors: Allen
authors: Paul N
authors: PN
authors: Appleby
authors: Kim
authors: K
authors: Overvad
authors: Henning
authors: H
authors: Grønbæk
authors: Anne
authors: A
authors: Tjønneland
authors: Jytte
authors: J
authors: Halkjær
authors: Laure
authors: L
authors: Dossus
authors: Heiner
authors: H
authors: Boeing
authors: Janine
authors: J
authors: Kröger
authors: Antonia
authors: A
authors: Trichopoulou
authors: Dimosthenis
authors: D
authors: Zylis
authors: Dimitrios
authors: D
authors: Trichopoulos
authors: Marie-Christine
authors: MC
authors: Boutron-Ruault
authors: Blandine
authors: B
authors: de Lauzon-Guillain
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: Domenico
authors: D
authors: Palli
authors: Franco
authors: F
authors: Berrino
authors: Salvatore
authors: S
authors: Panico
authors: Rosario
authors: R
authors: Tumino
authors: Carlotta
authors: C
authors: Sacerdote
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Carla H
authors: CH
authors: van Gils
authors: Petra H M
authors: PH
authors: Peeters
authors: Inger T
authors: IT
authors: Gram
authors: Laudina
authors: L
authors: Rodríguez
authors: Paula
authors: P
authors: Jakszyn
authors: Esther
authors: E
authors: Molina-Montes
authors: Carmen
authors: C
authors: Navarro
authors: Aurelio
authors: A
authors: Barricarte
authors: Nerea
authors: N
authors: Larrañaga
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Sheila
authors: S
authors: Rodwell
authors: Sabina
authors: S
authors: Rinaldi
authors: Nadia
authors: N
authors: Slimani
authors: Teresa
authors: T
authors: Norat
authors: Valentina
authors: V
authors: Gallo
authors: Elio
authors: E
authors: Riboli
authors: Rudolf
authors: R
authors: Kaaks
mesh_terms: D000328:Adult; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005060:Europe; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology; D009752:Nutritional Status; D012307:Risk Factors
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I