Chapter 1. Target selection in structural genomics projects to increase knowledge of protein structure and function space.
Structural genomics aims to solve the three-dimensional structures of proteins at a rapid rate and in a cost-effective manner, with the hope of significantly impacting on the life sciences, biotechnology, and drug discovery in the long-term. Structural genomics initiatives started in Japan in 1997 with the advent of the Protein Folds Project. Since then many new initiatives have begun worldwide, with diverse aims motivating the selection of proteins for structure determination. In this chapter, we consider the biological goals of high-throughput structural biology, while focusing on the Protein Structure Initiative in the United States. This is the most productive of the structural genomics initiatives, having solved 3,363 new structures between September 2000 and October 2008.
Carter
Phil
P
Department of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.
Lee
David
D
Orengo
Christine
C
D023281:Genomics; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
D011506:Proteins