Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor). The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. Particular emphasis is given to management of hydatidiform mole, including evacuation, twin mole/normal fetus pregnancy, prophylactic chemotherapy, and follow-up.
Lurain
John R
JR
John I. Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jlurain@nmff.org
D000032:Abortion, Therapeutic / Q000379:methods; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy / Q000473:pathology; D007044:Hysterectomy / Q000379:methods; D011247:Pregnancy; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy