title: Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial.
abstract: OBJECTIVE
  To study rates of relapse in remitted patients with first episode psychosis who either continued or discontinued antipsychotic drugs after at least one year of maintenance treatment.
  
  
  METHODS
  12 month randomised, double blind, placebo controlled trial.
  
  
  METHODS
  Early psychosis outpatient clinics in Hong Kong.
  
  
  METHODS
  178 patients with first episode psychosis who had received at least one year of antipsychotic drug treatment between September 2003 and July 2006 and had no positive symptoms of psychosis.
  
  
  METHODS
  Patients received either maintenance treatment with quetiapine (400 mg/day) or placebo and were followed up for the next 12 months or until a relapse occurred.
  
  
  METHODS
  Relapse assessed monthly and defined as re-emergence of psychotic symptoms (delusions, conceptual disorganisation, hallucinations, suspiciousness, and unusual thought content) according to predefined thresholds.
  
  
  RESULTS
  178 patients were randomised (89 to quetiapine and 89 to placebo). The Kaplan-Meier estimate of the risk of relapse at 12 months was 41% (95% confidence interval 29% to 53%) for the quetiapine group and 79% (68% to 90%) for the placebo group (P<0.001). Although quetiapine was generally well tolerated, the rate of discontinuation due to adverse or serious adverse events was greater in the quetiapine group (18%; 16/89) than in the placebo group (8%; 7/89) (relative risk 2.29, 95% confidence interval 0.99 to 5.28; chi(2)=3.20, df=1; P=0.07).
  
  
  CONCLUSIONS
  In a group of asymptomatic patients with first episode psychosis and at least one year of previous antipsychotic drug treatment, maintenance treatment with quetiapine compared with placebo resulted in a substantially lower rate of relapse during the following year. Trial registration Clinical trials NCT00334035.
authors: Department of Psychiatry, University of Hong Kong, Hong Kong. eyhchen@hku.hk
authors: Eric Y H
authors: EY
authors: Chen
authors: Christy L M
authors: CL
authors: Hui
authors: May M L
authors: MM
authors: Lam
authors: Cindy P Y
authors: CP
authors: Chiu
authors: C W
authors: CW
authors: Law
authors: Dicky W S
authors: DW
authors: Chung
authors: Steve
authors: S
authors: Tso
authors: Edwin P F
authors: EP
authors: Pang
authors: K T
authors: KT
authors: Chan
authors: Y C
authors: YC
authors: Wong
authors: Flora Y M
authors: FY
authors: Mo
authors: Kathy P M
authors: KP
authors: Chan
authors: T J
authors: TJ
authors: Yao
authors: S F
authors: SF
authors: Hung
authors: William G
authors: WG
authors: Honer
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy*; D000069348:Quetiapine Fumarate; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate