No evidence for an association of human papillomavirus and breast carcinoma.
Breast cancer represents a serious public health problem worldwide, for its high incidence, morbidity, mortality, and its high cost treatment. It is known that breast cancer is a multifactorial disease, possessing various risk factors, among which include hormonal factors, genetic and environmental. The role of viruses in breast carcinogenesis is controversial. This study aims to evaluate the expression of HPV 6, 11, 16, and 18 by polymerase chain reaction (PCR) in invasive ductal breast carcinoma. We analyzed 90 women diagnosed with invasive ductal breast carcinoma, of which the extracted DNA was amplified, quantified and tested for DNA subtypes 6, 11, 16, and 18 by PCR. The research carried out in 79 samples of HPV DNA, proved negative. Our study demonstrates no association between the most prevalent types of HPV and breast cancer.
Silva
Raimundo Gerônimo
RG
Department of Pathology, Federal University of Piauí, Teresina, Brazil.
da Silva
Benedito Borges
BB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D001943:Breast Neoplasms / Q000473:pathology / Q000821:virology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D052140:Human papillomavirus 11 / Q000302:isolation & purification; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D016133:Polymerase Chain Reaction; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
D004279:DNA, Viral