Serum high molecular weight adiponectin is associated with mild renal dysfunction in Japanese adults.
OBJECTIVE
Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults.


METHODS
We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ± standard deviation; range, 20-89) years and 1,056 women aged 62 ± 12 (range, 21-88) years) during their annual health examination in a single community. Participants with an eGFR of ≥ 60 mL/min/1.73 m² were divided into four groups based on quartiles of serum HMW adiponectin levels, and it was investigated whether serum HMW adiponectin is independently associated with eGFR.


RESULTS
Mean eGFR was significantly higher in the highest quartile than the lowest quartile of serum HMW adiponectin levels. Stepwise multiple linear regression analysis using eGFR as an objective variable, adjusted for confounding factors as explanatory variables, showed that serum HMW adiponectin (β=0.068) as well as age (β=-0.361), prevalence of antihypertensive medication (β=-0.115), triglycerides (β=-0.063), low-density lipoprotein cholesterol (β=-0.094), and fasting plasma glucose (β=0.148) were independently associated with eGFR. The multivariate-adjusted odds ratio for mild renal dysfunction of an eGFR < 70 mL/min/1.73 m² was 0.62 (95% CI, 0.42-0.91) for the highest quartile compared with participants with the lowest serum adiponectin quartile.


CONCLUSIONS
We conclude that a higher serum HMW adiponectin level is associated with a reduced odds ratio of mild renal dysfunction in Japanese adults.
Kawamoto
Ryuichi
R
Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@yahoo.jp
Tabara
Yasuharu
Y
Kohara
Katsuhiko
K
Miki
Tetsuro
T
Abe
Masanori
M
Kusunoki
Tomo
T
Katoh
Tateaki
T
Ohtsuka
Nobuyuki
N
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011379:Prognosis; D055815:Young Adult
D052242:Adiponectin; D015415:Biomarkers