title: Differential thresholds of neuromedins B-, C-, and bombesin-induced anorexia and crop-emptying rate in chicks.
abstract: Neuromedin B (NMB) and neuromedin C (NMC) are homologs of bombesin and are distributed throughout both the brain and gastrointestinal tract. The physiological roles of these bombesin-like peptides in chicks (Gallus gallus) have not been documented. Therefore, the purpose of the present study was to measure the effects of these bombesin-like peptides on food intake, crop-emptying rate and body temperature in chicks, and then to compare these effects with those of bombesin. Intracerebroventricular (ICV, 5 nmol) and intraperitoneal (IP, 300 nmol/kg) injections of NMB, NMC, and bombesin significantly decreased food deprivation-induced food intake. When ICV injected (5 nmol), all three peptides significantly reduced crop-emptying rate. IP injection of NMC and bombesin (300 nmol/kg) also reduced crop-emptying rate while NMB did not. The magnitude of food intake suppression and crop-emptying rate reduction were greater for bombesin than NMB and NMC. ICV and IP injections of NMB, NMC and bombesin did not affect cloacal temperature. In sum, the present study suggests that central and peripheral NMB and NMC are associated with reduced food intake and crop-emptying of chicks, but these effects are weaker than those of bombesin.
authors: Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan. tetsu@agr.ehime-u.ac.jp
authors: Tetsuya
authors: T
authors: Tachibana
authors: Kiyoko
authors: K
authors: Matsuda
authors: Haruna
authors: H
authors: Sawa
authors: Atsumi
authors: A
authors: Mikami
authors: Hiroshi
authors: H
authors: Ueda
authors: Mark A
authors: MA
authors: Cline
mesh_terms: D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D002645:Chickens; D004333:Drug Administration Routes; D004435:Eating / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D015287:Neurokinin B / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments; C040794:neuromedin C; D015287:Neurokinin B; C038393:neuromedin B; D001839:Bombesin