[Current trends of nicotine dependence].
This article reviews clinical features and neural mechanisms of nicotine dependence as well as medications for it. The ICD-10 and DSM-IV-TR classifications define nicotine dependence and nicotine withdrawal. The rewarding effects of nicotine have been reported to include a sense of well-being, increased vigilance, relaxation, anxiolytic effects, increased capacity to cope with stressors, and increased ability of learning and memory. These psychopharmacological effects of nicotine may be produced by the ability of nicotine to promote the release of catecholamines, acetylcholine, beta-endorphin, glucocorticoid, and other hormones. As for medications used to treat nicotine dependence, nicotine gum and nicotine patches are used to alleviate nicotine withdrawal, whereas bupropion, varenicline, and rimonabant are used to decrease rewarding effects of nicotine.
Miyata
Hisatsugu
H
Department of Psychiatry, Jikei University School of Medicine.
D006801:Humans; D013375:Substance Withdrawal Syndrome; D014029:Tobacco Use Disorder / Q000503:physiopathology