[Research progress on genomic integrity regulated by epigenetics using yeast as a model.].
Genomic integrity is crucial for normal cell replication, proliferation and differentiation. DNA lesions resulted from exogenous and endogenous factors will lead to genomic instability, and consequently the cause for various diseases. Epigenetic regulation (including DNA methylation, histone modifications and non-coding RNA) plays important roles in DNA lesion repair and cell cycle regulation as well as maintaining the genetic integrity. The yeast, a type of single cell eukaryotic organism, is an ideal model for the researches of epigenetics, especially in the area of DNA lesion repair and the formation of heterochromatin. Previous researches on epigenetics were mainly focus on histone modifications. Recent re-searches have observed that non-coding RNAs are able to direct the cytosine methylation and histone modifications that are related to gene expression regulation. This paper discuss the mechanism, research progress and future development of epi-genetics in maintaining the genomic integrity, using the yeast as a model.
Feng
Bi-Wei
BW
School of Life Sciences, Fudan University, Shanghai, China.
Chen
Jian-Qiang
JQ
Lei
Bing-Kun
BK
Pan
Xian
X
Lü
Hong
H
D004249:DNA Damage; D004260:DNA Repair; D044127:Epigenesis, Genetic; D042822:Genomic Instability; D006657:Histones / Q000378:metabolism; D010766:Phosphorylation; D015003:Yeasts / Q000235:genetics*
D006657:Histones