title: Randomized controlled trial of barbed polyglyconate versus polyglactin suture for robot-assisted laparoscopic prostatectomy anastomosis: technique and outcomes.
abstract: BACKGROUND
  Transperitoneal robot-assisted laparoscopic prostatectomy (RALP) urethrovesical anastomosis is a critical step. Although the prevalence of urine leaks ranges from 4.5% to 7.5% at high-volume RALP centers, urine leaks prolong catheterization and may lead to ileus, peritonitis, and require intervention. Barbed polyglyconate sutures maintain running suture line tension and may be advantageous in RALP anastomosis for reducing this complication.
  
  
  OBJECTIVE
  To compare barbed polyglyconate and polyglactin 910 (Vicryl, Ethicon, Somerville, NJ, USA) running sutures for RALP anastomosis.
  
  
  METHODS
  This was a prospective, randomized, controlled, single-surgeon study comparing RALP anastomosis using either barbed polyglyconate (n = 45) or polyglactin 910 (n = 36) sutures.
  
  
  METHODS
  RALP anastomosis using either barbed polyglyconate or polyglactin 910 sutures was studied.
  
  
  METHODS
  Operative time, cost differential, perioperative complications, and cystogram contrast extravasation by anastomosis suture type were measured.
  
  
  CONCLUSIONS
  Although baseline characteristics and overall operative times were similar, barbed polyglyconate sutures were associated with shorter mean anastomosis times of 9.7 min versus 9.8 min (p = 0.014). In addition, anastomosis with barbed polyglyconate rather than polyglactin 910 sutures was associated with more frequent cystogram extravasation 8 d postoperatively (20.0% vs 2.8%; p = 0.019), longer mean catheterization times (11.1 d vs 8.3 d; p = 0.048), and greater suture costs per case ($51.52 vs $8.44; p < 0.001). After 8 of 29 (27.6%) barbed polyglyconate anastomosis sites demonstrated postoperative day 8 cystogram extravasation, we modified our technique to avoid overtightening, reducing cystogram extravasation to 1 (6.3%) of 16 subsequent barbed polyglyconate anastomosis sites. Potential limitations include small sample size and the single-surgeon study design.
  
  
  CONCLUSIONS
  Compared to traditional sutures, barbed polyglyconate is more costly and requires technical modification to avoid overtightening, delayed healing, and longer catheterization time following RALP.
authors: Division of Urologic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors: Stephen B
authors: SB
authors: Williams
authors: Mehrdad
authors: M
authors: Alemozaffar
authors: Yin
authors: Y
authors: Lei
authors: Nathanael
authors: N
authors: Hevelone
authors: Stuart R
authors: SR
authors: Lipsitz
authors: Blakely A
authors: BA
authors: Plaster
authors: Jim C
authors: JC
authors: Hu
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical; D001900:Boston; D016009:Chi-Square Distribution; D003362:Cost-Benefit Analysis; D017721:Hospital Costs; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000191:economics / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D011098:Polyglactin 910 / Q000009:adverse effects / Q000191:economics; D011108:Polymers / Q000009:adverse effects / Q000191:economics; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects / Q000191:economics / Q000295:instrumentation* / Q000379:methods; D011471:Prostatic Neoplasms / Q000191:economics / Q000601:surgery*; D012371:Robotics / Q000191:economics / Q000295:instrumentation*; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000191:economics / Q000295:instrumentation*; D013536:Suture Techniques / Q000009:adverse effects / Q000191:economics / Q000295:instrumentation*; D013537:Sutures / Q000009:adverse effects / Q000191:economics; D013997:Time Factors; D016896:Treatment Outcome; D014546:Urinary Catheterization; D014945:Wound Healing
chemical_list: D011108:Polymers; D011098:Polyglactin 910; C046409:polyglyconate