Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design.
Magnetophoresis is a method of enhancement of drug permeation across the biological barriers by application of magnetic field. The present study investigated the mechanistic aspects of magnetophoretic transdermal drug delivery and also assessed the feasibility of designing a magnetophoretic transdermal patch system for the delivery of lidocaine. In vitro drug permeation studies were carried out across the porcine epidermis at different magnetic field strengths. The magnetophoretic drug permeation "flux enhancement factor" was found to increase with the applied magnetic field strength. The mechanistic studies revealed that the magnetic field applied in this study did not modulate permeability of the stratum corneum barrier. The predominant mechanism responsible for magnetically mediated drug permeation enhancement was found to be "magnetokinesis". The octanol/water partition coefficient of drugs was also found to increase when exposed to the magnetic field. A reservoir type transdermal patch system with a magnetic backing was designed for in vivo studies. The dermal bioavailability (AUC(0-6h)) from the magnetophoretic patch system in vivo, in rats was significantly higher than the similarly designed non-magnetic control patch.
Murthy
S Narasimha
SN
Department of Pharmaceutics, The University of Mississippi, University, MS 38677, USA. murthy@olemiss.edu
Sammeta
Srinivasa M
SM
Bowers
C
C
D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004058:Diffusion; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods*; D004817:Epidermis / Q000378:metabolism*; D005240:Feasibility Studies; D008012:Lidocaine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008280:Magnetics; D008297:Male; D010539:Permeability; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption; D012995:Solubility; D013552:Swine
D000779:Anesthetics, Local; D004304:Dosage Forms; D008012:Lidocaine