title: Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities.
abstract: Three methods are utilized to synthesize a variety of 6,8-di-C-glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-alpha expression and NO production with IC(50) values of 6.8 and 5.2 muM, respectively.
authors: The Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
authors: Jiun-Jie
authors: JJ
authors: Shie
authors: Chih-An
authors: CA
authors: Chen
authors: Chih-Chien
authors: CC
authors: Lin
authors: Angela Fay
authors: AF
authors: Ku
authors: Ting-Jen R
authors: TJ
authors: Cheng
authors: Jim-Min
authors: JM
authors: Fang
authors: Chi-Huey
authors: CH
authors: Wong
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D031667:Dendrobium / Q000737:chemistry; D047309:Flavones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006031:Glycosylation; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D047309:Flavones; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide