Fine needle aspiration cytologic features of Cherubism: a case report.
BACKGROUND
Cherubism is characterized by hereditary and intraosseous fibrous swellings of the jaws. It presents with bilateral mandibular and maxillary involvement in young individuals. Fine needle aspiration cytologic (FNAC) features have rarely been described in the literature; they include smears showing moderate cellularity with spindle cells mixed with multinucleated giant cells of osteoclast type. Therefore, giant cell containing soft tissue and bone lesions are considered in the differential diagnosis.


METHODS
A 13-year-old girl presented with bilateral symmetrical mandibular enlargement and was diagnosed as having cherubism on FNAC.


CONCLUSIONS
We describe the cytomorphologic features of cherubism along with its differential diagnosis on cytology and emphasize that with clinicoradiologic correlation, a specific diagnosis can be offered for a definitive therapeutic approach.
Gupta
Nalini
N
Department of Cytopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. nalini203@rediffmail.com
Duggal
Rajan
R
Rajwanshi
Arvind
A
Rattan
Vidya
V
D000293:Adolescent; D044963:Biopsy, Fine-Needle; D017824:Bone Cysts, Aneurysmal / Q000175:diagnosis; D002636:Cherubism / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000175:diagnosis; D015726:Giant Cells / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000175:diagnosis; D006801:Humans; D008334:Mandible / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis; D011859:Radiography