title: Adult hypertension is associated with blood pressure variability in childhood in blacks and whites: the bogalusa heart study.
abstract: BACKGROUND
  Blood pressure (BP) is a variable physiological parameter in health and disease. Increased BP variability over time in adults is associated with severity of end-organ damage and a higher rate of cardiovascular events, even after adjusting for the mean levels. This study tested the hypothesis that childhood BP variability, besides the mean levels, is also predictive of adulthood hypertension.
  
  
  METHODS
  The study cohort consisted of 1,797 subjects (1,091 whites and 706 blacks; age = 21-48 years) enrolled in the Bogalusa Heart Study since childhood. BP variability was depicted as s.d. of 4-8 serial measurements in childhood.
  
  
  RESULTS
  Blacks showed significantly greater childhood systolic BP (SBP) variability than whites. In multivariable logistic regression analyses, adjusting for race, sex, mean childhood age, s.d. of childhood body mass index (BMI), mean childhood BP levels, adulthood age and BMI, adult hypertension was significantly associated with s.d. of childhood SBP (odds ratio (OR) (95% confidence intervals) = 1.28 (1.09, 1.51), P = 0.002) and s.d. of childhood diastolic BP (DBP; 1.36 (1.16, 1.58), P < 0.001). When using adulthood BP levels as continuous dependent variables in linear regression models, adjusting for the same covariates, adulthood SBP and DBP levels were significantly associated with s.d. of childhood SBP (standardized regression coefficient β = 0.086, P < 0.001) and s.d. of childhood DBP (β = 0.105, P < 0.001), respectively.
  
  
  CONCLUSIONS
  Increases in BP variations as well as levels in early life are predictive of adult hypertension, which underscore the childhood origin of the natural history of essential hypertension.
authors: Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
authors: Wei
authors: W
authors: Chen
authors: Sathanur R
authors: SR
authors: Srinivasan
authors: Litao
authors: L
authors: Ruan
authors: Hao
authors: H
authors: Mei
authors: Gerald S
authors: GS
authors: Berenson
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology; D016014:Linear Models; D008875:Middle Aged; D044465:White People