Mechanochemistry of magnesium oxide revisited: facile derivatisation of pharmaceuticals using coordination and supramolecular chemistry.
Liquid-assisted grinding allows the rapid, waste-free and one-pot synthesis of a variety of magnesium drug derivatives directly from the excipient MgO; such reactivity is relevant for the behaviour of ibuprofen formulations involving MgO and can be used for oxide-based mechanosynthesis of metal-organic salts, discrete complexes and carboxylate clusters involving magnesium and pharmaceutically active ingredients.
Chow
Ernest H H
EH
Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
Strobridge
Fiona C
FC
Friscić
Tomislav
T
D007052:Ibuprofen / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008277:Magnesium Oxide / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
D046911:Macromolecular Substances; D009942:Organometallic Compounds; D010087:Oxides; D004364:Pharmaceutical Preparations; D008277:Magnesium Oxide; D007052:Ibuprofen