title: p66(shc)'s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone.
abstract: Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling in mediating mitophagy and determining neuronal cell fate following acute oxygen glucose deprivation.
authors: Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, USA.
authors: Amy M
authors: AM
authors: Kleman
authors: Jacquelynn E
authors: JE
authors: Brown
authors: Stephanie L H
authors: SL
authors: Zeiger
authors: Jane C
authors: JC
authors: Hettinger
authors: Joshua D
authors: JD
authors: Brooks
authors: Benjamin
authors: B
authors: Holt
authors: Jason D
authors: JD
authors: Morrow
authors: Erik S
authors: ES
authors: Musiek
authors: Ginger L
authors: GL
authors: Milne
authors: BethAnn
authors: B
authors: McLaughlin
mesh_terms: D000328:Adult; D001343:Autophagy / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D019194:Ischemic Preconditioning; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure*; D010084:Oxidation-Reduction; D011494:Protein Kinases / Q000378:metabolism; D055765:Shc Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D020521:Stroke / Q000473:pathology / Q000503:physiopathology
chemical_list: C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D011494:Protein Kinases