A centrosome kinase modulates antitumor drug sensitivity.
In this issue of Cancer Cell, Ahmed and coworkers identify SIK2 as a centrosome kinase and show that it controls the localization of the centriole linker protein C-Nap1. Interference with SIK2 function results in loss of normal mitotic spindle function and increased sensitivity to antitumor drugs.
Salisbury
Jeffrey L
JL
Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, MN 55905, USA. salisbury@mayo.edu