title: The immune response in glaucoma: a perspective on the roles of oxidative stress.
abstract: Neurodegenerative insults and glial activation during glaucomatous neurodegeneration initiate an immune response to restore tissue homeostasis and facilitate tissue cleaning and healing. However, increasing risk factors over a chronic and cumulative period may lead to a failure in the regulation of innate and adaptive immune response pathways and represent a route for conversion of the beneficial immunity into a neuroinflammatory degenerative process contributing to disease progression. Oxidative stress developing through the pathogenic cellular processes of glaucoma, along with the aging-related component of oxidative stress, likely plays a critical role in shifting the physiological equilibrium. This review aims to provide a perspective on the complex interplay of cellular events during glaucomatous neurodegeneration by proposing a unifying scheme that integrates oxidative stress-related risk factors with the altered regulation of immune response in glaucoma.
authors: Department of Ophthalmology & Visual Sciences, University of Louisville, Louisville, KY, USA. gulgun.tezel@louisville.edu
authors: Gülgün
authors: G
authors: Tezel
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D005901:Glaucoma / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D009901:Optic Nerve Diseases / Q000276:immunology*; D018384:Oxidative Stress