title: Testosterone metabolism and formation of cytosol 5alpha-dihydrotestosterone-receptor complex in the rat prostate in vitro: Effects of lindane and malathion.
abstract: The effects of gamma-1,2,3,4,5,6-hexachlorocyclohexane (lindane) and O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate (malathion) on testosterone metabolism in rat prostate tissue in vitro was investigated. The influence of lindane on the formation of 5alpha-androstan-17beta-ol-3-one (5alpha-DHT)-receptor complex in the rat prostatic cytosol has also been examined. Lindane and malathion inhibited the formation of 5alpha-DHT, and lindane caused a decrease in the formation of 5alpha-androstane-3,17-dione (androstanedione) in the rat prostate tissue. A mixture of lindane and malathion exerted a synergistic effect on testosterone metabolism in the rat prostate, as indicated by lower 5alpha-DHT and higher 5alpha-androstane-3alpha,17beta-diol formation. The presence of lindane significantly inhibited 5alpha-DHT-receptor complex formation in the rat prostatic cytosol, and this inhibition was of a fully noncompetitive type.
authors: Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 41000 Zagreb, Croatia.
authors: B
authors: B
authors: Simić
authors: D
authors: D
authors: Bogojević
authors: S
authors: S
authors: Trikić
authors: J
authors: J
authors: Kniewald