Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women.
OBJECTIVE
Evaluate the effect of diet, physical exercise, and a daily oral intake of a soy isoflavones extract (Fisiogen(®)) contained 200 mg of Glycine max, which corresponded to 80 mg of isoflavone (60.8 mg of genistein, 16 mg of daidzein and 3.2 mg of glicitein) on leptin and other adipokines plasma levels in healthy obese postmenopausal women.


METHODS
A multicentric randomized longitudinal prospective cohort study was conducted in a sample of 87 healthy obese postmenopausal women. Patients were randomly assigned to a 1200 kcal diet and exercise group (control group) or a group of 1200 kcal diet, exercise, and daily oral intake of daily oral intake of a soy isoflavones extract (Fisiogen(®)) contained 200 mg of Glycine max, which corresponded to 80 mg of isoflavone (60.8 mg of genistein, 16 mg of daidzein and 3.2 mg of glicitein) (soy isoflavones group) along 6 months. Main outcome measures were: anthropometric measures, body composition, leptin, adiponectin, TNF-alpha, homocysteine, C-reactive protein, glucose, insulin, lipid profile and oestradiol serum levels, Kupperman index and Cervantes Scale.


RESULTS
Mean serum leptin and TNF-alpha levels declined after 6 months in both groups of the study, but only women in the soy isoflavones group showed a significant increase of mean serum levels of adiponectin.


CONCLUSIONS
Diet, physical exercise and daily oral intake of a soy isoflavones extract (Fisiogen(®)) contained 200 mg of Glycine max, which corresponded to 80 mg of isoflavone (60.8 mg of genistein, 16 mg of daidzein and 3.2 mg of glicitein) have a beneficial effect on serum leptin, adiponectin and TNF-α in healthy obese postmenopausal women after 6 months of treatment.
Llaneza
Placido
P
Department of Obstetrics and Gynecology, Central University Hospital of Asturias, C/Celestino Villamil s/n, 33006 Oviedo, Asturias, Spain. pllanezac@yahoo.es
González
Celestino
C
Fernandez-Iñarrea
José
J
Alonso
Ana
A
Diaz
Fernando
F
Arnott
Ignacio
I
Ferrer-Barriendos
Javier
J
D054392:Adipokines / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004032:Diet; D015444:Exercise / Q000502:physiology*; D005260:Female; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology* / Q000627:therapeutic use; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000628:therapy; D048789:Phytoestrogens / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D017698:Postmenopause / Q000097:blood / Q000187:drug effects; D011446:Prospective Studies; D013025:Glycine max / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D016387:Women's Health
D054392:Adipokines; D016207:Cytokines; D007529:Isoflavones; D020738:Leptin; D048789:Phytoestrogens; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C004742:daidzein; D019833:Genistein