The role of inflammation in ICU-acquired weakness.
A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this finding is somewhat equivocal, it provides important direction for future investigations and illustrates the challenges of interpreting significance in small observational studies.
Winkelman
Chris
C
Frances Payne Bolton School of Nursing, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA. chris.winkelman@case.edu
D006801:Humans; D007362:Intensive Care Units; D015850:Interleukin-6 / Q000502:physiology; D018908:Muscle Weakness / Q000209:etiology* / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications* / Q000503:physiopathology
D015850:Interleukin-6