title: X-linked inhibitor of apoptosis protein as a therapeutic target in metastatic melanoma.
abstract: Melanoma is the most dangerous type of skin cancer, with notorious resistance to current chemotherapy and immunotherapy. In this issue, Hiscutt et al. report on the prognostic significance of X-linked inhibitor of apoptosis protein (XIAP) in melanoma. The finding that XIAP inhibition significantly increases endoplasmic reticulum stress-mediated apoptosis in melanoma cells suggests that XIAP is a potential therapeutic target for melanoma therapy.
authors: Cutaneous Biology Research Center, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02129, USA.
authors: Fang
authors: F
authors: Tian
authors: Sam W
authors: SW
authors: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human