Postinfluenza bacterial pneumonia: host defenses gone awry.
Influenza is a common respiratory pathogen causing both seasonal and pandemic disease. Influenza infection predisposes the host to secondary bacterial infection of the respiratory tract, which is a major cause of both morbidity and mortality in flu-related disease. In this review, we will discuss innate and adaptive antiviral responses during influenza infection, and review how these responses modulate protective immunity against secondary bacterial pathogens of the lung. Specific emphasis will be placed on implications of bacterial superinfection and mechanisms involved.
Ballinger
Megan N
MN
Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA.
Standiford
Theodore J
TJ
D056704:Adaptive Immunity; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D016867:Immunocompromised Host; D008168:Lung / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D012306:Risk; D015163:Superinfection / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D014481:United States