[Investigating the "social brain" through Williams syndrome].
Recent advances in social cognitive neuroscience have led to the concept of the "social brain". The social brain includes neural processes specialized for processing social information necessary for the recognition of self and others, and interpersonal relationships. Because of its unique behavioral phenotypic features which includes 'hypersociability', Williams syndrome has gained popularity among social cognitive neuroscientists. Individuals with Williams syndrome share the same genetic risk factor for cognitive-behavioral dysfunction utilizing brain imaging to elucidate endophenotype provides us with an unprecendented opportunity to study gene, brain and behavior relationships especially those related to social cognition. In this review, we provide an overview of neuroimaging studies on social cognition in Williams syndrome and discuss the neural basis of the social brain.
Nagamine
Masanori
M
Department of Psychiatry, Japan Self Defense Force Fukuoka Hospital, Kasuga-shi, Fukuoka, Japan.
Mimura
Masaru
M
Reiss
Allan L
AL
Hoeft
Fumiko
F
D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003071:Cognition; D004532:Ego; D006801:Humans; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging; D012919:Social Behavior; D018980:Williams Syndrome / Q000235:genetics / Q000473:pathology* / Q000523:psychology*