Evolving microbiology of complicated acute otitis media before and after introduction of the pneumococcal conjugate vaccine in France.
We compare the microbiology of otopathogens causing recurrent acute otitis media (AOM) or AOM treatment failure in 600 children during 2000 to 2008 before and after the introduction of 7-valent pneumococcal conjugate vaccine (PCV-7). Streptococcus pneumoniae predominated before PCV-7 introduction and during 2007 to 2008, whereas Haemophilus influenzae predominated during 2005 to 2006. S. pneumoniae 19A became the most frequent serotype after PCV-7 introduction.
Dupont
Damien
D
Service de Microbiologie, Hôpital Robert Debré (AP-HP), Paris, Université Denis-Diderot-Paris7, France.
Mahjoub-Messai
Farah
F
François
Martine
M
Doit
Catherine
C
Mariani-Kurkdjian
Patricia
P
Bidet
Philippe
P
Bonacorsi
Stéphane
S
Carol
Agnès
A
Bingen
Edouard
E
D000208:Acute Disease; D002675:Child, Preschool; D005602:France / Q000453:epidemiology; D006192:Haemophilus Infections / Q000453:epidemiology / Q000382:microbiology; D006193:Haemophilus influenzae / Q000302:isolation & purification*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010033:Otitis Media / Q000453:epidemiology* / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data
D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines