title: Multivalent ions control the transport through lysenin channels.
abstract: We report the effect of different ions on the conducting properties of lysenin channels inserted into planar lipid bilayer membranes. Our observations indicated that multivalent ions inhibited the lysenin channels conductance in a concentration dependent manner. The analysis performed on single channels revealed that multivalent ions induced reversible sub-conducting or closed states depending on the ionic charge and size. Good agreement is reported between experimental results and a theoretical model that is proposed to describe the interaction between divalent ions and lysenin channels as a simple isothermal absorption process.
authors: Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701, USA. dfologea@uark.edu
authors: Daniel
authors: D
authors: Fologea
authors: Eric
authors: E
authors: Krueger
authors: Redwan
authors: R
authors: Al Faori
authors: Rachel
authors: R
authors: Lee
authors: Yuriy I
authors: YI
authors: Mazur
authors: Ralph
authors: R
authors: Henry
authors: Mark
authors: M
authors: Arnold
authors: Greg J
authors: GJ
authors: Salamo
mesh_terms: D000042:Absorption; D017136:Ion Transport; D007477:Ions / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D014118:Toxins, Biological / Q000737:chemistry* / Q000502:physiology
chemical_list: D007477:Ions; D008051:Lipid Bilayers; D008670:Metals; D014118:Toxins, Biological; C107040:lysenin