[The relationship between genotypes and frequencies of chromosome aberrations in human lymphocytes under irradiation in vivo and in vitro].
The data on the variability of an elevated level of the frequencies of chromosome aberrations for a group of liquidators of the Chernobyl Nuclear Station accident depending on genotypes by candidate loci are presented. The genotyping was carried out by sites, which previously showed the associations with the cytogenetic variability in control experiments. It was shown that, for a group of liquidators heterozygote by site SOD2 C47T, the control level of the frequency of chromosome aberrations is not exceeded significantly. At the tendency level, the frequency of aberrations for liquidators was reduced for double homozygotes by deletions of genes GSTM1-GSTT1 and for homozygotes by the minor allele of site CYP1A1 T606G that is in an accordance with the results of experiments with the control sampling. The elevated level of chromosome aberrations for liquidators, as a whole, is observed for genotypes, which are characteristic of an elevated level of spontaneous aberrations, and it does not completely correspond to genotypes with the elevated radiosensitivity of chromosomes.
Sal'nikova
L E
LE
Chumachenko
A G
AG
Vesnina
I N
IN
Lapteva
N Sh
NSh
Kuznetsova
G I
GI
Abilev
S K
SK
Rubanovich
A V
AV
D000483:Alleles; D002478:Cells, Cultured; D047852:Chernobyl Nuclear Accident; D002869:Chromosome Aberrations; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D004247:DNA / Q000528:radiation effects; D005720:Gamma Rays; D005787:Gene Frequency; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics; D000099156:Superoxide Dismutase 2
D019363:Cytochrome P-450 CYP1A1; D004247:DNA; D005982:Glutathione Transferase; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C413545:glutathione S-transferase T1