[Effect of lipid free radical oxidation on renal functional status in patients with alcohol withdrawal syndrome].
OBJECTIVE
to study the activity of free radical processes in patients with alcoholism and renal lesion (A+RL) and the implication of depressed efficiency of the regulatory mechanisms limiting the accumulation of highly toxic products of lipid free radical oxidation (LFRO) in the development of secondary nephropathy.


METHODS
Fifty-seven patients (mean age 31 +/- 2.8 years) with a 5-10 history of alcoholism who had been admitted to hospital for uncomplicated alcohol withdrawal syndrome were examined. Alcoholic renal lesion was detected in 17 (29.8%) patients. A control group comprised 20 healthy individuals. The activity of LFRO and antioxidative defense (AOD) was studied.


RESULTS
In patients with alcoholism, the study indicators reflecting the activity of LFRO statistically significantly exceeded those in the group of healthy individuals. These patients were found to have also suppressed mechanisms of first- and second-line AOD in the A+RL group.


CONCLUSIONS
LFRO activation developing in the presence of suppressed AOD seems to contribute to the development of secondary nephropathy in patients with alcoholism.
Sibireva
O F
OF
Khitrinskaia
E Iu
EIu
Kaliuzhin
V V
VV
Kaliuzhina
E V
EV
D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D000975:Antioxidants / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007677:Kidney Function Tests; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology
D000975:Antioxidants; D005609:Free Radicals