title: A highly efficient asymmetric Michael addition of α,α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt.
abstract: The first highly efficient Michael addition of challenging α,α-disubstituted aldehydes to maleimides catalyzed by a simple bifunctional primary amine thiourea catalyst/benzoic acid system has been successfully developed to generate quaternary carbon centers in high yields (up to 99%) with excellent enantioselectivities (91-99%).
authors: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors: Feng
authors: F
authors: Yu
authors: Zhichao
authors: Z
authors: Jin
authors: Huicai
authors: H
authors: Huang
authors: Tingting
authors: T
authors: Ye
authors: Xinmiao
authors: X
authors: Liang
authors: Jinxing
authors: J
authors: Ye
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D019817:Benzoic Acid / Q000737:chemistry; D002384:Catalysis; D008301:Maleimides / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D008301:Maleimides; D019817:Benzoic Acid; D013890:Thiourea