[Progress of CypA and lung cancer-related research].
CypA is the most important member of Cyclophilins. It is a widely expressed protein in nature possessing PPIase and chaperone activities which help the precise folding of protein. Also, it is involved in immunosuppression, inflammation and the balance of cholesterol. As the understanding of CypA function has deepened, people began to realize that there might exist a relationship between CypA and cancer. Lung cancer is the first carcinoma which was found as expressing high level of CypA. CypA plays the roles in increasing proliferation, antiapoptosis, invasion and metastasis in lung cancer. The study of CypA may open a new window for the early diagnosis, prognosis and novel therapeutic drugs targeting.
Qian
Zhe
Z
General Department, Beijing Chest Hospital, Beijing 101149, China.
Yue
Wentao
W
Li
Baolan
B
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D021984:Cyclophilin A / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
D021984:Cyclophilin A