title: The impact of dialysis modality on arterial stiffness in patients with end-stage renal disease.
abstract: BACKGROUND
  Arterial stiffness determined by brachial-ankle pulse wave velocity (baPWV) has been established as a powerful predictor of cardiovascular mortality in hemodialysis (HD) patients. There are, however, few studies regarding the comparative impact of different renal replacement therapies (RRTs) on PWV. Therefore, we conducted a cross-sectional study to compare arterial wall properties and cardiac function between patients treated with continuous ambulatory peritoneal dialysis (CAPD) and those with HD who were matched for age, dialysis duration, and blood pressure.
  
  
  METHODS
  baPWV and transthoracic echocardiography (TTE) were performed in HD patients (n = 23) after 1 h of midweek dialysis session and CAPD patients (n = 26) with empty abdomen after drainage of dialysate. The baseline data were retrospectively reviewed.
  
  
  RESULTS
  baPWV was significantly higher in HD patients than in CAPD patients (18.1 +/- 2.8 vs. 16.1 +/- 2.7 m/s, p = 0.015). TTE revealed significantly increased E/E', left atrial volume index (LAVI), and inferior vena cava (IVC) diameter index in HD patients compared with CAPD patients (p < 0.05). In a multivariate regression analysis adjusted for dialysis modality, age, systolic BP, residual glomerular filtration rate, diabetes, and echocardiographic parameters, HD was independently associated with increased baPWV.
  
  
  CONCLUSIONS
  This study showed that HD patients had significantly increased arterial stiffness and severe diastolic dysfunction compared with CAPD patients.
authors: Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
authors: Jae Hyun
authors: JH
authors: Chang
authors: Se-Jung
authors: SJ
authors: Yoon
authors: Seung Hyeok
authors: SH
authors: Han
authors: Sug Kyun
authors: SK
authors: Shin
authors: Dong Woon
authors: DW
authors: Jeon
authors: Joo Young
authors: JY
authors: Yang
authors: Ea Wha
authors: EW
authors: Kang
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011673:Pulsatile Flow / Q000502:physiology*; D012189:Retrospective Studies; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*