Influence of glycemic control on Epstein-Bar and Cytomegalovirus infection in periodontal pocket of type 2 diabetic subjects.
OBJECTIVE
The aim of the present study was to evaluate the influence of glycemic control on the frequency of Epstein-Bar (EBV) and Cytomegalovirus (CMV) in periodontal pockets of type 2 diabetic subjects with chronic periodontitis.


METHODS
Forty-six subjects presenting generalized chronic periodontitis and type 2 diabetes mellitus (DM) were selected for this study. Polymerase chain reaction (PCR) was used to determine the presence of EBV and CMV in shallow [Probing Depth (PD)≤3mm], moderate (PD=4-6mm) and deep (PD>7mm) pockets. HbA1c levels ≤7%, >7 to <10%, and ≥10% defined good, moderate and poor glycemic control, respectively.


RESULTS
Higher frequency of EBV was found in the shallow pockets of the subjects with poor glycemic control (p<0.05; chi-square test). Moreover, EBV-free subjects presented moderate or good glycemic control. Glycemic control did not influence the frequency of CMV in all pocket categories.


CONCLUSIONS
Poor glycemic control in type 2 diabetic subjects can increase the occurrence of EBV in shallow periodontal pockets.
Casarin
Renato Corrêa Viana
RC
Department of Prosthodontics and Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
Duarte
Poliana Mendes
PM
Santos
Vanessa Renata
VR
Lima
Jadson Almeida
JA
Gagnon
Guy
G
Casati
Márcio Zaffalon
MZ
Gonçalves
Reginaldo Bruno
RB
D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000821:virology*; D010518:Periodontitis / Q000821:virology; D016133:Polymerase Chain Reaction; D019562:Viral Load
D001786:Blood Glucose