[Association of XAGE-1 gene expression with clinical characteristics of lung cancer].
OBJECTIVE
XAGE-1 is a cancer-testis (CT) antigen which was demonstrated to be expressed at a significant frequency and to be immunogenic in some tumors. The aim of this study is to explore the association between XAGE-1 gene expression and the clinical characteristics of lung cancer.


METHODS
Tumor tissue and adjacent lung tissue samples from 85 patients were screened for expression of the four XAGE-1 transcript variants by nest PCR. The correlations between XAGE-1b gene expression and several clinical characteristics were analyzed.


RESULTS
32.94% (28/85) of lung cancer samples were positive for XAGE-1 gene. 59.46% (22/37) of the adencarcinoma samples and 21.74% (5/23) of the squamous cell carcinoma samples were positive for one of the four XAGE-1 transcript variants. The frequent of XAGE-1b gene in adencarcinoma was much higher than that in squamous cell carcinoma. There were not any important correlation between XAGE-1b gene expression and clinical characteristics, such as gender, age and clinical stage.


CONCLUSIONS
XAGE-1 gene is highly expressed in lung adenocarcinoma and XAGE-1 may be a promising immunotherapeutic target for lung cancer.
Lai
Qun
Q
Department of Thoracic Surgery, Central Hospital of Coal Group of Zaozhuang, Zaozhuang 277011, China. tjll@163.com
Zhang
Litang
L
Sun
Yan
Y
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D000951:Antigens, Neoplasm; C413656:XAGE1A protein, human