title: Practical synthesis of quinoxalinones via palladium-catalyzed intramolecular N-arylations.
abstract: A practical and highly efficient route to the synthesis of pharmaceutically interesting quinoxalinone scaffolds is reported. The key step involves an intramolecular palladium-catalyzed N-arylation under microwave irradiation. The developed methodology tolerates a variety of bromoanilides to afford a diverse collection of bicyclic and polycyclic quinoxalinones in high yield.
authors: Department of Medicinal Chemistry, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Ville Saint-Laurent (Montreal), Quebec H4S 1Z9 Canada. xuehong.luo@astrazeneca.com
authors: Xuehong
authors: X
authors: Luo
authors: Etienne
authors: E
authors: Chenard
authors: Peter
authors: P
authors: Martens
authors: Yun-Xing
authors: YX
authors: Cheng
authors: Mirosław J
authors: MJ
authors: Tomaszewski
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011810:Quinoxalines; D010165:Palladium