Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis.
Drug-loadingmesoporous silica nanoparticles that serve as a nanoreservoir-type drug-delivery system are successfully attached to titanium substrates via the layer-by-layer assembly technique (see scheme). The obtained structure demonstrates great potential for regulating the biological behaviors of osteoblasts/ steoclasts in order to maintain bone homeostasis. The approach we present here may have wide applications in implant technology, tissue engineering, and regenerative medicine.
Hu
Yan
Y
Chongqing University, China.
Cai
Kaiyong
K
Luo
Zhong
Z
Jandt
Klaus D
KD
D000818:Animals; D000831:Animals, Newborn; D001842:Bone and Bones / Q000378:metabolism; D002113:Calcification, Physiologic; D004958:Estradiol / Q000737:chemistry*; D006706:Homeostasis; D053758:Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D053495:Osteopontin / Q000235:genetics / Q000378:metabolism; D053244:Osteoprotegerin / Q000235:genetics / Q000378:metabolism; D016062:Porosity; D051381:Rats; D044968:Regenerative Medicine; D012822:Silicon Dioxide / Q000737:chemistry*; D023822:Tissue Engineering; D014025:Titanium / Q000737:chemistry
D053244:Osteoprotegerin; D053495:Osteopontin; D004958:Estradiol; D012822:Silicon Dioxide; D014025:Titanium