title: Thrombophilic gene mutations in women with repeated spontaneous miscarriage.
abstract: OBJECTIVE
  One of the main problems concerning repeated spontaneous miscarriage (RSM) is the etiological diagnosis. The relation of thrombophilia to RSM is a matter of debate. In this case-control study, we determined the percentages of three thrombophilic mutations (factor V leiden, prothrombin, and methylenetetrahydrofolate reductase) amongst 20 cases with RSM and 20 control normal parous women.
  
  
  RESULTS
  There were high statistically significant increases in the number of cases with factor V, prothrombin, and methylenetetrahydrofolate reductase gene mutations compared with normal control and the percentage of multiple gene mutations was higher than single gene mutation.
  
  
  CONCLUSIONS
  The prevalence of thrombophilic mutations is higher in cases of RSM than control.
authors: Department of Obstetrics and Gynecology, Benha Faculty of Medicine, Benha, Egypt. mahamadsalam@hotmail.com
authors: Mohamed A
authors: MA
authors: Mohamed
authors: Mahasen A
authors: MA
authors: El Moaty
authors: Adel F
authors: AF
authors: El Kholy
authors: Shuzan A
authors: SA
authors: Mohamed
authors: Amal I
authors: AI
authors: Ali
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000150:complications / Q000235:genetics*; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)