title: Use of fibrin-based thromboelastometry for cryoprecipitate transfusion in cardiac surgery involving deep hypothermic circulatory arrest during cardiopulmonary bypass.
abstract: We aimed to assess the predictive value of fibrin-based thromboelastometry performed before weaning from cardiopulmonary bypass (CPB) for cryoprecipitate administered to correct the bleeding diathesis after CPB involving deep hypothermic circulatory arrest. Eleven patients undergoing aortic surgery were enrolled. The arterial blood was withdrawn before skin incision, 30 min before CPB weaning (Cweaning), 5 min after protamine reversal (Preversal) and at closure of the sternum to run intrinsically activated INTEM, heparinase-treated HEPTEM, extrinsically activated EXTEM and platelet-inhibited FIBTEM analysis, platelet count, fibrinogen, prothrombin time (international normalized ratio) and activated partial thromboplastin time. The predicted value of FIBTEM A10 obtained during CPB for cryoprecipitate transfusion at Preversal was calculated. The cut-off points for FIBTEM A10 to reflect fibrinogen of 200 mg/dl at Preversal were 5 mm (P = 0.15). FIBTEM A10 at Preversal and Cweaning showed correlations as follows: FIBTEM A10 at Preversal = 0.02 + 1.42 × FIBTEM A10 at Cweaning (r² = 0.80). The cut-off value for FIBTEM A10 at Cweaning to determine whether to prepare cryoprecipitate in advance during CPB was calculated to be 3 mm, and the positive and negative predictability for FIBTEM A10 of 3 or less versus more than 3 at Cweaning for the necessity of cryoprecipitate transfusion at Preversal (A10 ≤ 5 versus > 5) were 100 and 80%, respectively. This study showed that fibrinogen reflected in FIBTEM during pump can be used to estimate FIBTEM after Preversal and the amount of cryoprecipitate needed for replacing mainly the fibrinogen could be predicted with high sensitivity and specificity.
authors: Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Sang Hyun
authors: SH
authors: Lee
authors: Sangmin M
authors: SM
authors: Lee
authors: Chung Su
authors: CS
authors: Kim
authors: Hyun Sung
authors: HS
authors: Cho
authors: Gaab Soo
authors: GS
authors: Kim
authors: Mi Sook
authors: MS
authors: Gwak
authors: Choo Hoon
authors: CH
authors: Chang
authors: Kiick
authors: K
authors: Sung
mesh_terms: D000368:Aged; D001011:Aorta / Q000601:surgery; D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000379:methods; D002315:Cardiopulmonary Bypass / Q000379:methods*; D050792:Circulatory Arrest, Deep Hypothermia Induced / Q000379:methods*; D005337:Fibrin; D005340:Fibrinogen / Q000008:administration & dosage*; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D011237:Predictive Value of Tests; D013916:Thrombelastography / Q000379:methods*
chemical_list: D005337:Fibrin; D005340:Fibrinogen