Severe complication after a doxorubicin-eluting-bead embolization: surgical management and pathological findings.
Doxorubicin-eluting-bead embolization (DEB) is considered a safe and efficient treatment of hepatocellular carcinoma (HCC) with a low complication rate and an increased tumor response compared with conventional transarterial chemoembolization. We describe a case of a 69-year-old patient who underwent DEB for HCC and who developed a liver abscess requiring urgent left liver lobectomy. Despite this severe complication, efficacy of DEB embolization was histologically proved as a large ischemic zone with complete tumor necrosis.
Lesevic
Veiba
V
Pôle des Pathologies Digestives, Hépatique et Transplantation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg-Université de Strasbourg, Avenue Molière, 67098 Strasbourg Cedex, France. veiba@hotmail.com
Marzano
Ettore
E
Greget
Michel
M
Rosso
Edoardo
E
Bachellier
Philippe
P
Pessaux
Patrick
P
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D003131:Combined Modality Therapy; D015897:Comorbidity; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004630:Emergencies; D004825:Epiglottis; D004927:Escherichia coli Infections / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy; D008099:Liver / Q000473:pathology; D008100:Liver Abscess / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D008863:Microspheres; D009336:Necrosis; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000628:therapy; D012008:Recurrence; D012086:Reoperation; D012772:Shock, Septic / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin