title: Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives.
abstract: With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.
authors: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai, 400019, India.
authors: Yogesh Y
authors: YY
authors: Pedgaonkar
authors: Mariam S
authors: MS
authors: Degani
authors: Radhakrishnan P
authors: RP
authors: Iyer
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D005561:Formates / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010705:Phosgene / Q000031:analogs & derivatives / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D000178:Acrylamides; D000588:Amines; D005561:Formates; D009570:Nitriles; C030544:formic acid; D010705:Phosgene; C111044:bis(trichloromethyl) carbonate; D014498:Uracil; C031594:2-cyanoacetamide