[The age dynamics of spontaneous and induced in vitro chromosome aberrations in human lymphocytes under natural and radiation induced senescence].
The frequency of translocations, detected by FISH in lymphocytes of control donors increased with increasing age as quadratic function. This process is elevated in persons exposed to radiation at low-doses. It means that the level of translocations could be used as an indicator of biological age. Moreover the frequency of translocations should be taken into account when biological reconstruction of absorbed dose is carried out. The frequency of dicentrics, detected by FISH and FPG methods increased with age in both groups compared and in equal rate, the linear model being fit the data best. The rate of age-increase for translocations is much higher than for dicentrics. Chromosomal radiosensitivity of lymphocytes in vitro tends to increase with age in control group and significantly decrease--in exposed one, that is low-dose radiation exposure changes the character of age dependence of cytogenetic radiosensitivity.
Vorobtsova
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Semenov
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D000367:Age Factors; D001600:Berberine Alkaloids; D002877:Chromosomes, Human / Q000235:genetics / Q000528:radiation effects*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects; D016273:Occupational Exposure; D010617:Phenanthridines; D011827:Radiation; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000235:genetics*; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D012426:Russia; D014178:Translocation, Genetic / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain