[The use of the deuterated internal standard for morphine quantitation for the purpose of doping control by gas chromatography with mass-selective detection].
The objective of this study was to demonstrate the possibility to use deuterated compounds as internal standards for the quantitative analysis of morphine by gas chromatography with mass-selective detection for the purpose of doping control. The paper is focused on the problems associated with the use of deuterated morphine-D3 as the internal standard. Quantitative characteristics of the calibration dependence thus documented are presented along with uncertainty values obtained in the measurements with the use of deuterated morphine-D6. An approach to the assessment of method bias associated with the application of morphine-D6 as the deuterated internal standard is described.
Savel'eva
N B
NB
Bykovskaia
N Iu
NIu
Dikunets
M A
MA
Bolotov
S L
SL
Rodchenkov
G M
GM
D000701:Analgesics, Opioid / Q000032:analysis*; D003903:Deuterium / Q000032:analysis* / Q000737:chemistry; D004300:Doping in Sports / Q000517:prevention & control*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D009020:Morphine / Q000032:analysis*; D012015:Reference Standards
D000701:Analgesics, Opioid; D009020:Morphine; D003903:Deuterium