title: A comparison of two brief screening measures of cognitive impairment in Huntington's disease.
abstract: The goal of this study was to explore whether the Montreal Cognitive Assessment (MoCA), a new screening instrument, would be more sensitive to mild to moderate cognitive impairment in Huntington's disease (HD) than an established screening measure, the Mini Mental State Exam (MMSE). Our reasoning for this query is that the MoCA includes a broader range of test items and an additional assessment of executive functioning and attention compared with the MMSE. Using the receiver operating characteristic (ROC) analysis to examine performance of HD and control groups on both tests on overall scores and scores from various subdomains (i.e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE.
authors: Department of Psychology, University of California, San Diego, La Jolla, California 92093-0109, USA. lmickes@ucsd.edu
authors: Laura
authors: L
authors: Mickes
authors: Mark
authors: M
authors: Jacobson
authors: Guerry
authors: G
authors: Peavy
authors: John T
authors: JT
authors: Wixted
authors: Stephanie
authors: S
authors: Lessig
authors: Jody L
authors: JL
authors: Goldstein
authors: Jody
authors: J
authors: Corey-Bloom
mesh_terms: D000328:Adult; D019540:Area Under Curve; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012372:ROC Curve