Synthesis and solid state structure of a hydrazone-disulfide macrocycle and its dynamic covalent ring-opening under acidic and basic conditions.
The synthesis and characterisation, including solid state structure, of a macrocycle containing both a hydrazone and a disulfide linkage is described. Selective ring-opening of the macrocycle under thermodynamic control could be achieved at either the disulfide or the hydrazone linkage by applying mutually exclusive sets of reaction conditions.
von Delius
Max
M
School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, UKEH9 3JJ.
Geertsema
Edzard M
EM
Leigh
David A
DA
Slawin
Alexandra M Z
AM