Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes.
Environmental and age-related effects on learning and memory were analysed and compared with changes observed in astrocyte laminar distribution in the dentate gyrus. Aged (20 months) and young (6 months) adult female albino Swiss mice were housed from weaning either in impoverished conditions or in enriched conditions, and tested for episodic-like and water maze spatial memories. After these behavioral tests, brain hippocampal sections were immunolabeled for glial fibrillary acid protein to identify astrocytes. The effects of environmental enrichment on episodic-like memory were not dependent on age, and may protect water maze spatial learning and memory from declines induced by aging or impoverished environment. In the dentate gyrus, the number of astrocytes increased with both aging and enriched environment in the molecular layer, increased only with aging in the polymorphic layer, and was unchanged in the granular layer. We suggest that long-term experience-induced glial plasticity by enriched environment may represent at least part of the circuitry groundwork for improvements in behavioral performance in the aged mice brain.
Diniz
Daniel G
DG
Universidade Federal do Pará-UFPA, Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Brazil.
Foro
César A R
CA
Rego
Carla M D
CM
Gloria
David A
DA
de Oliveira
Fabio R R
FR
Paes
Juliana M P
JM
de Sousa
Aline A
AA
Tokuhashi
Tatyana P
TP
Trindade
Lucas S
LS
Turiel
Maíra C P
MC
Vasconcelos
Erick G R
EG
Torres
João B
JB
Cunnigham
Colm
C
Perry
Victor H
VH
Vasconcelos
Pedro F da Costa
PF
Diniz
Cristovam W P
CW
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D018891:Dentate Gyrus / Q000502:physiology*; D004777:Environment; D005260:Female; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D009474:Neurons / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology*