Acute fatty liver of pregnancy in a Taiwanese tertiary care center: a retrospective review.
OBJECTIVE
To evaluate the demographics, clinical presentations, laboratory findings, and maternal and fetal outcomes in patients with acute fatty liver of pregnancy.


METHODS
A retrospective review was conducted of the records of pregnant patients with a diagnosis of acute fatty liver in a tertiary medical center over a 22-year period.


RESULTS
Eighteen patients with acute fatty liver of pregnancy were recruited, all of whom developed the disease in the third trimester. Eleven women (61%) were primigravid and four (22%) had twin pregnancies; six (33%) were diagnosed antepartum, and the other 12 (67%) were diagnosed postpartum. There were two maternal deaths (11%) and four fetal deaths (18%). The most common complications apart from severe liver dysfunction were acute renal failure (83%), hypoglycemia (61%), and disseminated intravascular coagulation (61%).


CONCLUSIONS
Women who become acutely ill during the third trimester of pregnancy should undergo tests for acute fatty liver of pregnancy, including laboratory tests for assessing liver function and coagulation profile.
Lau
Hui-Hsuan
HH
Division of High Risk Pregnancy, Mackay Memorial Hospital, Taipei, Taiwan.
Chen
Yi-Yung
YY
Huang
Jian-Pei
JP
Chen
Chen-Yu
CY
Su
Tsung-Hsien
TH
Chen
Chie-Pein
CP
D058186:Acute Kidney Injury / Q000150:complications; D000328:Adult; D001034:Apgar Score; D002585:Cesarean Section / Q000706:statistics & numerical data; D002784:Cholesterol / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005234:Fatty Liver / Q000150:complications* / Q000401:mortality; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D033461:Hyperuricemia / Q000150:complications; D007003:Hypoglycemia / Q000150:complications; D007902:Length of Stay / Q000706:statistics & numerical data; D007964:Leukocytosis / Q000150:complications; D050498:Live Birth; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011248:Pregnancy Complications; D011263:Pregnancy Trimester, Third; D011517:Prothrombin Time; D012189:Retrospective Studies; D050497:Stillbirth; D013624:Taiwan
D005340:Fibrinogen; D002784:Cholesterol