Cooperative and uncooperative cyclic-nucleotide-gated ion channels.
Ion channels gated by cyclic nucleotides serve multiple functions in sensory signaling in diverse cell types ranging from neurons to sperm. Newly discovered members from bacteria and marine invertebrates provide a wealth of structural and functional information on this channel family. A hallmark of classical tetrameric cyclic-nucleotide-gated channels is their cooperative activation by binding of several ligands. By contrast, the new members seem to be uncooperative, and binding of a single ligand molecule suffices to open these channels. These new findings provide a fresh look at the mechanism of allosteric activation of ion channels.
Cukkemane
Abhishek
A
Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Seifert
Reinhard
R
Kaupp
U Benjamin
UB
D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000737:chemistry / Q000378:metabolism*; D015640:Ion Channel Gating; D008024:Ligands; D011485:Protein Binding
D054815:Cyclic Nucleotide-Gated Cation Channels; D008024:Ligands