Prospective 15-year study of neuromuscular function in a cohort of patients with prior poliomyelitis.
Poliomyelitis is a monophasic illness affecting lower motor neurons and individuals may describe new problems years after the initial weakness. We have studied 38 people with the post-polio syndrome over a 15-year period assessing a number of neuromuscular measures, including motor unit number estimation (MUNE). Twenty-five individuals reported progressive weakness but there was no objective change in MUNE and other measures. There was an association with reported weakness and initial deficits. There was a slow decline in MUNE values over time in both groups.
Daube
Jasper R
JR
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. daube.jasper@mayo.edu
Sorenson
Eric J
EJ
Windebank
Anthony J
AJ
D000200:Action Potentials / Q000502:physiology; D004558:Electric Stimulation / Q000379:methods; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000473:pathology*; D009431:Neural Conduction / Q000502:physiology; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000209:etiology*; D011051:Poliomyelitis / Q000150:complications*; D016262:Postpoliomyelitis Syndrome / Q000150:complications*