TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes.
A unique property of lymphocytes among all body tissues is their capacity for rapid proliferation in the context of responding to infectious challenges. Lymphocyte proliferation involves a transition from a quiescent metabolic state adjusted to maintain cellular energy homeostasis, to a proliferative metabolic state in which aerobic glycolysis is used to generate energy and biosynthetic precursors necessary for the accumulation of cell mass. Here we show that modulation of TRPM7 channel function in tumor B-lymphocytes directly induces quiescent/proliferative metabolic transitions. As TRPM7 is widely expressed outside of the immune system, our results suggest that TRPM7 may play an active role in regulating metabolic transitions associated with rapid cellular proliferation and malignancy.
Sahni
Jaya
J
Department of Pediatrics and Immunology, University of Washington, Seattle Children's Research Institute, Seattle, WA, USA.
Tamura
Richard
R
Sweet
Ian R
IR
Scharenberg
Andrew M
AM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001402:B-Lymphocytes / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D049109:Cell Proliferation; D002645:Chickens; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology; D006019:Glycolysis; D053078:Membrane Potential, Mitochondrial / Q000502:physiology; D010101:Oxygen Consumption; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D050053:TRPM Cation Channels; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004318:Doxycycline; D002118:Calcium