Synthesis of nucleotidylated poliovirus VPg proteins.
Phosphitylation of the side chain hydroxyl function of Fmoc protected tyrosine with 5'-phosphoramidites of suitably protected cytidine, adenosine, and guanosine, followed by oxidation gave three novel nucleotidylated amino acid building blocks. After protective group manipulation, these building blocks were used in a solid phase peptide synthesis to afford the nucleotidylated poliovirus proteins VPgpC, VPgpA, and VPgpG.
van der Heden van Noort
Gerbrand J
GJ
Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Overkleeft
Herman S
HS
van der Marel
Gijsbert A
GA
Filippov
Dmitri V
DV
D000596:Amino Acids / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010766:Phosphorylation; D017955:Poliovirus / Q000737:chemistry*; D015678:Viral Structural Proteins / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D009943:Organophosphorus Compounds; D015678:Viral Structural Proteins