Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions.
Methionine binding converts monofunctional platinum antitumor agents to trans configuration adducts in the reaction with DNA, which suggests the correlation of two classes of platinum complexes in the antitumor mechanism.
Ma
Guolin
G
Department of Chemistry, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Min
Yuanzeng
Y
Huang
Fan
F
Jiang
Tao
T
Liu
Yangzhong
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D005399:Fishes; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D013440:Sulfides; D004247:DNA