The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents.
Obesity is characterized as an inflammatory state associated with a modification in the pattern of adipokine secretion. The present study aimed to assess the role of anorexigenic and orexigenic neuropeptides and peripheral signals in obese adolescents submitted to 1 year of weight loss interdisciplinary therapy and grouped according to quartiles of weight loss. A total of 111 post-puberty adolescents, with a BMI >95th percentile, were included. Glycemia and lipid profiles were analyzed. Insulin resistance was estimated by HOMA-IR. Cytokine concentrations were measured by ELISA. The results are presented according to quartiles of weight loss: 1st (<2.5 kg)=low; 2nd (2.5-8 kg)=low to moderate; 3rd (8-14 kg)=moderate; and 4th (>14 kg)=massive. The most important finding was that the NPY concentration increased significantly only in the first phase of weight loss. Moreover, α-MSH variation was an independent factor in explaining the NPY changes during the intervention, confirming the role of the α-MSH concentration in the peripheral control of energy balance in obese adolescents. Indeed, BMI reduction was correlated with increased α-MSH (p<0.05). Massive weight loss promoted a significant increase in α-MSH concentration, and hyperleptinemia was reduced after intervention. All together, our findings, which contribute to our understanding of how orexigenic and anorexigenic systems are regulated by weight loss, will provide insight into the pathogenesis and treatment of obesity and other metabolic diseases, especially in obese adolescents.
Oyama
Lila Missae
LM
Post Graduate Program of Nutrition, Federal University of São Paulo-Unifesp, São Paulo, SP, Brazil.
do Nascimento
Claudia Maria Oller
CM
Carnier
June
J
de Piano
Aline
A
Tock
Lian
L
Sanches
Priscila de Lima
Pde L
Gomes
Fabíola Alvise Corrêa
FA
Tufik
Sergio
S
de Mello
Marco Túlio
MT
Dâmaso
Ana R
AR
D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D009765:Obesity / Q000503:physiopathology*; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
D009479:Neuropeptides