title: Terpenes from the soft corals Litophyton arboreum and Sarcophyton ehrenbergi.
abstract: The new cembrane diterpene (3E,11E)-cembra-3,8(19),11,15-tetraene-7alpha-ol (1), nephthenol (2), and all-trans-peridinin (3) have been isolated from the soft coral Litophyton arboreum. The tetraterpene 3, (+)-7,8-epoxy-7,8-dihydrocembrene C (4), emblide (5), sarcophytoxide (6), sarcoglaucol-16-one (7), guajacophine (8), and 1,4-peroxymuurol-5-ene (9) have been obtained from the soft coral Sarcophyton ehrenbergi. The compounds were characterized primarily by NMR spectroscopy. Some of the terpenes were tested for their antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa, and they showed moderate activities.
authors: Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, D-95440 Bayreuth.
authors: Kamel H
authors: KH
authors: Shaker
authors: Michael
authors: M
authors: Müller
authors: M Abdel
authors: MA
authors: Ghani
authors: Hans-Martin
authors: HM
authors: Dahse
authors: Karlheinz
authors: K
authors: Seifert
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000145:classification*; D000970:Antineoplastic Agents / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy; D013729:Terpenes / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes