title: Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.
abstract: Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n=4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) =0.0067; odds ratio=1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.
authors: MRC-SGDP Centre, Institute of Psychiatry, Kings College, UK.
authors: Sylvane
authors: S
authors: Desrivières
authors: Anbarasu
authors: A
authors: Lourdusamy
authors: Christian
authors: C
authors: Müller
authors: Francesca
authors: F
authors: Ducci
authors: Cybele P
authors: CP
authors: Wong
authors: Marika
authors: M
authors: Kaakinen
authors: Anneli
authors: A
authors: Pouta
authors: Anna-Liisa
authors: AL
authors: Hartikainen
authors: Matti
authors: M
authors: Isohanni
authors: Pimphen
authors: P
authors: Charoen
authors: Leena
authors: L
authors: Peltonen
authors: Nelson
authors: N
authors: Freimer
authors: Paul
authors: P
authors: Elliott
authors: Marjo-Riitta
authors: MR
authors: Jarvelin
authors: Gunter
authors: G
authors: Schumann
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000428:Alcohol Drinking / Q000235:genetics; D000435:Alcoholic Intoxication / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012737:Sex Factors
chemical_list: C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid