Association of monocyte chemotactic protein-1 and CC chemokine receptor 2 gene variants with preeclampsia.
Preeclampsia complicates 10% of pregnancies in developing countries. It is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. It has been suggested that maladaptation of the maternal immune response during pregnancy might be a causal factor for preeclampsia. According to immune maladaptation hypothesis, preeclampsia is due to an inappropriate regulation of normally Th2-deviated maternal immune responses, leading to a shift toward harmful Th1 immunity. Several studies indicate that monocyte chemotactic protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) are involved in Th1 and Th2 immunity. In this study, we investigated the association between MCP-1 A-2518G and CCR2-V64I polymorphisms and preeclampsia. One hundred eighty preeclamptic pregnant women and 145 healthy controls were included in the study. We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia.
Agachan
Bedia
B
Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey. agachanb@yahoo.com
Attar
Rukset
R
Isbilen
Elif
E
Aydogan
Hulya Yilmaz
HY
Sozen
Seyma
S
Gurdol
Figen
F
Isbir
Turgay
T
D000293:Adolescent; D000328:Adult; D018932:Chemokine CCL2 / Q000235:genetics* / Q000276:immunology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D018811:Maternal Exposure; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D011247:Pregnancy; D054390:Receptors, CCR2 / Q000235:genetics* / Q000276:immunology; D058408:Th1-Th2 Balance; D014421:Turkey
C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D054390:Receptors, CCR2