title: Mouse phenotyping.
abstract: Model organisms like the mouse are important tools to learn more about gene function in man. Within the last 20 years many mutant mouse lines have been generated by different methods such as ENU mutagenesis, constitutive and conditional knock-out approaches, knock-down, introduction of human genes, and knock-in techniques, thus creating models which mimic human conditions. Due to pleiotropic effects, one gene may have different functions in different organ systems or time points during development. Therefore mutant mouse lines have to be phenotyped comprehensively in a highly standardized manner to enable the detection of phenotypes which might otherwise remain hidden. The German Mouse Clinic (GMC) has been established at the Helmholtz Zentrum München as a phenotyping platform with open access to the scientific community (www.mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2]).
authors: Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 München/Neuherberg, Germany.
authors: Helmut
authors: H
authors: Fuchs
authors: Valérie
authors: V
authors: Gailus-Durner
authors: Thure
authors: T
authors: Adler
authors: Juan Antonio
authors: JA
authors: Aguilar-Pimentel
authors: Lore
authors: L
authors: Becker
authors: Julia
authors: J
authors: Calzada-Wack
authors: Patricia
authors: P
authors: Da Silva-Buttkus
authors: Frauke
authors: F
authors: Neff
authors: Alexander
authors: A
authors: Götz
authors: Wolfgang
authors: W
authors: Hans
authors: Sabine M
authors: SM
authors: Hölter
authors: Marion
authors: M
authors: Horsch
authors: Gabi
authors: G
authors: Kastenmüller
authors: Elisabeth
authors: E
authors: Kemter
authors: Christoph
authors: C
authors: Lengger
authors: Holger
authors: H
authors: Maier
authors: Mikolaj
authors: M
authors: Matloka
authors: Gabriele
authors: G
authors: Möller
authors: Beatrix
authors: B
authors: Naton
authors: Cornelia
authors: C
authors: Prehn
authors: Oliver
authors: O
authors: Puk
authors: Ildikó
authors: I
authors: Rácz
authors: Birgit
authors: B
authors: Rathkolb
authors: Werner
authors: W
authors: Römisch-Margl
authors: Jan
authors: J
authors: Rozman
authors: Rui
authors: R
authors: Wang-Sattler
authors: Anja
authors: A
authors: Schrewe
authors: Claudia
authors: C
authors: Stöger
authors: Monica
authors: M
authors: Tost
authors: Jerzy
authors: J
authors: Adamski
authors: Bernhard
authors: B
authors: Aigner
authors: Johannes
authors: J
authors: Beckers
authors: Heidrun
authors: H
authors: Behrendt
authors: Dirk H
authors: DH
authors: Busch
authors: Irene
authors: I
authors: Esposito
authors: Jochen
authors: J
authors: Graw
authors: Thomas
authors: T
authors: Illig
authors: Boris
authors: B
authors: Ivandic
authors: Martin
authors: M
authors: Klingenspor
authors: Thomas
authors: T
authors: Klopstock
authors: Elisabeth
authors: E
authors: Kremmer
authors: Martin
authors: M
authors: Mempel
authors: Susanne
authors: S
authors: Neschen
authors: Markus
authors: M
authors: Ollert
authors: Holger
authors: H
authors: Schulz
authors: Karsten
authors: K
authors: Suhre
authors: Eckhard
authors: E
authors: Wolf
authors: Wolfgang
authors: W
authors: Wurst
authors: Andreas
authors: A
authors: Zimmer
authors: Martin
authors: M
authors: Hrabě de Angelis
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001774:Blood Chemical Analysis / Q000379:methods; D002386:Cataract / Q000473:pathology; D007677:Kidney Function Tests / Q000379:methods; D051379:Mice; D008817:Mice, Mutant Strains; D008818:Mice, Neurologic Mutants; D016296:Mutagenesis; D010147:Pain Measurement / Q000379:methods / Q000592:standards; D010641:Phenotype; D012015:Reference Standards; D016482:Urinalysis / Q000379:methods