Efficacy of allicin in decreasing lead (Pb) accumulation in selected tissues of lead-exposed common carp (Cyprinus carpio).
The objective of this study was to evaluate the effects of allicin, the main biologically active component of garlic clove extracts, on lead levels in different common carp tissues including liver, kidney, brain, bone, and blood following experimental lead poisoning. Fish were divided randomly into five groups depending on the combination of lead acetate and allicin treatments. Lead acetate exposure (7.0 mgL(-1), 10 days) caused a significant increase in mean Pb concentrations in all examined tissues in comparison to control unexposed fish (p < 0. 001). The results showed that allicin supplementation is effective in decreasing lead accumulation in all examined tissues of common carp. The promising ameliorative effects of allicin on tissue lead levels of common carp make it a good candidate for therapeutic intervention of lead poisoning. However, more studies are required to elucidate the pharmacokinetic effects of allicin and also molecular basis of the ameliorative properties of allicin in lead poisoning.
Shahsavani
Davar
D
Department of Food Hygiene and Aquaculture, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Baghshani
Hasan
H
Alishahi
Elias
E
D000818:Animals; D002347:Carps / Q000378:metabolism*; D004220:Disulfides; D007854:Lead / Q000378:metabolism* / Q000633:toxicity; D007855:Lead Poisoning / Q000188:drug therapy; D013441:Sulfinic Acids / Q000493:pharmacokinetics / Q000627:therapeutic use*
D004220:Disulfides; D013441:Sulfinic Acids; D007854:Lead; C006452:allicin