title: Effectiveness of misoprostol for office hysteroscopy without anesthesia in infertile patients.
abstract: OBJECTIVE
  To evaluate and compare the effectiveness of oral and vaginal misoprostol versus placebo to facilitate office hysteroscopy without anesthesia during infertile diagnostic evaluation.
  
  
  METHODS
  Randomized, prospective trial.
  
  
  METHODS
  Patients scheduled for diagnostic office hysteroscopy at a university hospital.
  
  
  METHODS
  Seventy-five infertile patients scheduled for diagnostic office hysteroscopy.
  
  
  METHODS
  Patients were divided into three groups: group A received oral misoprostol 600 μg; group B, vaginal misoprostol 400 μg; and group C, oral placebo.
  
  
  METHODS
  Pain, evaluated by visual analogue scale, and surgical time were recorded and compared. Statistical analysis was done using Student's t-test.
  
  
  RESULTS
  Pain was low in the vaginal misoprostol group. Mean visual analogue scale in the oral misoprostol group was 6.04 ± 1.5; in the vaginal misoprostol group 2.85 ± 1.2; and in the placebo group 7.50 ± 1.5. Procedural time for office hysteroscopy was shorter in the vaginal misoprostol group (2.7 ± 1.0 minutes) compared with group A (5.5 ± 1.1 minutes) and group C (6.3 ± 3.8 minutes).
  
  
  CONCLUSIONS
  Vaginal misoprostol, 400 μg, administered the day before office hysteroscopy considerably reduces pain and the time needed for hysteroscopy. This simple strategy may facilitate office hysteroscopy during an infertility work-up.
authors: Department of Obstetrics and Gynecology, University Center of Reproductive Medicine, Hospital Universitario Dr Jose E Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico. lsordia@prodigy.net.mx
authors: Luis Humberto
authors: LH
authors: Sordia-Hernández
authors: Elizabeth
authors: E
authors: Rosales-Tristan
authors: Juanita
authors: J
authors: Vazquez-Mendez
authors: Martha
authors: M
authors: Merino
authors: Jose Luis
authors: JL
authors: Iglesias
authors: Jose Gerardo
authors: JG
authors: Garza-Leal
authors: Arturo
authors: A
authors: Morales
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000758:Anesthesia / Q000379:methods; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D007247:Infertility, Female / Q000601:surgery*; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis; D010919:Placebos; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010919:Placebos; D016595:Misoprostol