title: Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer.
abstract: BACKGROUND
  Adult granulosa cell tumor associated with antecedent use of tamoxifen as adjuvant hormonotherapy for breast cancer is rare. The pathogenesis of this occurrence remains difficult to explain. The estrogenic effect of tamoxifen can be one such explanation.
  
  
  METHODS
  A 47 year-old women was treated with surgery, chemotherapy, radiotherapy and tamoxifen for stage III estrogen receptor positive breast carcinoma. Ten months after stopping tamoxifen, we diagnosed a stage Ic granulosa cell tumor of the ovary.
  
  
  CONCLUSIONS
  Use of tamoxifen has been found to be associated with gynecological tumors like endometrial carcinoma. Its association with granulosa cell tumor of the ovary is uncommon. Only two previous cases have been reported in literature.
authors: National institute of oncology, Rabat, Morocco. abahssainhalima@yahoo.fr
authors: Halima
authors: H
authors: Abahssain
authors: Mouna
authors: M
authors: Kairouani
authors: Robert
authors: R
authors: Gherman
authors: Hind
authors: H
authors: M'rabti
authors: Hassan
authors: H
authors: Errihani
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D011379:Prognosis; D013629:Tamoxifen / Q000009:adverse effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen