[Longitudinal study of health related quality of life in multiple sclerosis: correlation with MRI parameters].
BACKGROUND
Health related quality of life (HRQOL) is often affected in multiple sclerosis (MS). Nevertheless, to our knowledge, there is no longitudinal study in the literature about the correlation between MRI parameters and HRQOL in MS patients.


METHODS
We included 28 patients with clinically definite relapsing remitting MS. All patients initiated subcutaneous interferon beta-1a therapy. To assess HRQOL, we used the SEP-59 scale, the French validated translation of MSQOL-54, and the MusiQoL scale. Conventional MRI was performed every year. Lesion load (LL) and brain atrophy were automatically measured using SepINRIA, a free software developed by INRIA in Sophia Antipolis.


RESULTS
The mean EDSS score was 1.7 and disease duration was 2.5 years. Our results revealed that HRQOL was significantly correlated to T1 and T2-LL with both SEP-59 and MusiQoL scales. T1-LL was better correlated with physical dimensions and T2-LL was better correlated with mental components. At 1-year follow-up, patients whose MRI showed either an increase of T1 LL or at least one gadolinium enhancing lesion had a worse HRQOL at the end of the study. Initial brain parenchymal fraction (BPF) measure was also correlated with the long-term follow-up HRQOL. EDSS scored at the end of the study had not significantly changed (1.3; P>0.05).


CONCLUSIONS
Our study revealed pertinent clinicoradiological correlations between HRQOL and MRI parameters in our cohort.
Cohen
M
M
Service de neurologie, hôpital Pasteur, CHU de Nice, 30, voie Romaine, BP69, 06002 Nice cedex, France. cohen.m@chu-nice.fr
Lebrun
C
C
Aufauvre
D
D
Chanalet
S
S
Filleau-Bertogliatti
C
C
Camu
W
W
Thomas
P
P
Malandain
G
G
Clavelou
P
P
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D005682:Gadolinium; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007370:Interferon Type I / Q000627:therapeutic use; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D011788:Quality of Life; D011994:Recombinant Proteins; D055815:Young Adult
D003287:Contrast Media; D007370:Interferon Type I; D011994:Recombinant Proteins; D005682:Gadolinium