title: A novel handheld device for use in remote patient monitoring of heart failure patients--design and preliminary validation on healthy subjects.
abstract: Remote patient monitoring (RPM) holds great promise for reducing the burden of congestive heart failure (CHF). Improved sensor technology and effective predictive algorithms can anticipate sudden decompensation events. Enhanced telemonitoring systems would promote patient independence and facilitate communication between patients and their physicians. We report the development of a novel hand-held device, called Blue Box, capable of collecting and wirelessly transmitting key cardiac parameters derived from three integrated biosensors: 2 lead electrocardiogram (ECG), photoplethysmography and bioelectrical impedance (bioimpedance). Blue Box measurements include time intervals between consecutive ECG R-waves (RR interval), time duration of the ECG complex formed by the Q, R and S waves (QRS duration), bioimpedance, heart rate and systolic time intervals. In this study, we recruited 24 healthy subjects to collect several parameters measured by Blue Box and assess their value in correlating with cardiac output measured with Echo-Doppler. Linear correlation between the heart rate measured with Blue Box and cardiac output from Echo-Doppler had a group average correlation coefficient of 0.80. We found that systolic time intervals did not improve the model significantly. However, STIs did inversely correlate with increasing workloads.
authors: College of Technology, University of Houston, Houston, TX, USA. lpollonini@uh.edu
authors: Luca
authors: L
authors: Pollonini
authors: Nithin O
authors: NO
authors: Rajan
authors: Shuai
authors: S
authors: Xu
authors: Sridhar
authors: S
authors: Madala
authors: Clifford C
authors: CC
authors: Dacso
mesh_terms: D002302:Cardiac Output; D034201:Computers, Handheld; D004562:Electrocardiography; D006333:Heart Failure / Q000175:diagnosis*; D006801:Humans; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D017156:Photoplethysmography; D054928:Validation Studies as Topic; D059015:Wireless Technology / Q000295:instrumentation*