Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis--a comparison.
This perspective presents and assesses the development and capabilities of tip-enhanced Raman scattering (TERS) since its discovery in 2000. So far, this technique has proven to be valuable for studies of a variety of inorganic, organic and biochemical specimens. Due to its ability to provide chemical and topographic characterization in a single experiment at a sub-100 nm resolution, TERS has gained importance in super-resolution structural analysis. In this contribution the focus is set on applications with relevance in the biology and medical fields. The potential and challenges of this near-field technique are discussed with respect to state-of-the-art microscopic and spectroscopic imaging methods. Furthermore, possible ways to surpass current boundaries and an outlook to future projects are presented.
Deckert-Gaudig
Tanja
T
Institute for Photonic Technology, Albert-Einstein. Str. 9, D-07745 Jena, Germany. tanja.deckert-gaudig@ipht-jena.de
Deckert
Volker
V
D013058:Mass Spectrometry; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D013050:Spectrometry, Fluorescence; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods*