Impaired free water excretion in child C cirrhosis and ascites: relations to distal tubular function and the vasopressin system.
BACKGROUND
Water retention in advanced cirrhosis and ascites may involve disturbances in renal distal tubular function and in the vasopressin system.


METHODS
Twelve patients with Child B cirrhosis and ascites were compared with 11 patients with Child C cirrhosis and ascites. The subjects were studied during a 400 ml/h oral water load.


RESULTS
Child C patients had a lower baseline glomerular filtration rate (32 vs 63 ml/min, P<0.001) and a lower urinary flow rate (V(u)) (0.86 vs 1.95 ml/min, P<0.001) than the Child B patients. However, the free water clearance (C(H2O)) did not differ (-0.60 vs -0.21 ml/min, P=0.20). After the water loading, plasma vasopressin (AVP) decreased significantly in both the groups (P<0.05). The Child B patients had increased V(u) (1.95-3.24 ml/min, P<0.001) and C(H2O) (-0.21-1.21 ml/min, P<0.01) and distal fractional water excretion (10.5 vs 0% in Child C, P=0.01) and aquaporin-2 (AQP2) (P<0.058) after water loading. In contrast, the Child C patients did not have increased V(u) and C(H2O) in response to the water and the decrease in AVP. Furthermore, the markers of distal tubular water regulation, AQP2 excretion and distal fractional water excretion, were unaltered.


CONCLUSIONS
In Child C cirrhosis, ascites and mild hyponatraemia, there is an impaired ability to excrete solute-free water. The patients are characterised by a low glomerular filtration rate, a low distal tubular flow and an inability to increase free water clearance during water loading. This may be related to a vasopressin-independent production of AQP2.
Krag
Aleksander
A
Department of Gastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Hvidovre, Denmark. aleksanderkrag@hotmail.com
Møller
Søren
S
Pedersen
Erling B
EB
Henriksen
Jens H
JH
Holstein-Rathlou
Niels-Henrik
NH
Bendtsen
Flemming
F
D001201:Ascites / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D001834:Body Water / Q000378:metabolism*; D004231:Diuresis / Q000502:physiology; D005260:Female; D006801:Humans; D007686:Kidney Tubules, Distal / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014667:Vasopressins / Q000378:metabolism*; D014883:Water-Electrolyte Imbalance / Q000378:metabolism*
D014667:Vasopressins