title: Photocleavable polyethylene glycol for the light-regulation of protein function.
abstract: PEGylation is commonly employed to enhance the pharmacokinetic properties of proteins, but it can interfere with natural protein function. Protein activity can thus be abrogated through PEGylation, and a controllable means to remove the polyethylene glycol (PEG) group from the protein is desirable. As such, light affords a unique control over biomolecules through the application of photosensitive groups. Herein, we report the synthesis of a photocleavable PEG reagent (PhotoPEG) and its application to the light-regulation of enzyme activity.
authors: Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
authors: Wesleigh E
authors: WE
authors: Georgianna
authors: Hrvoje
authors: H
authors: Lusic
authors: Andrew L
authors: AL
authors: McIver
authors: Alexander
authors: A
authors: Deiters
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism*; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014466:Ultraviolet Rays
chemical_list: D011092:Polyethylene Glycols; D009113:Muramidase