title: Unprotected left main coronary disease and ST-segment elevation myocardial infarction: a contemporary review and argument for percutaneous coronary intervention.
abstract: Acute occlusion involving the unprotected left main coronary artery (ULMCA) is a clinically catastrophic event, often leading to abrupt and severe circulatory failure, lethal arrhythmias, and sudden cardiac death. Although coronary artery bypass grafting (CABG) is the standard of care for ULMCA disease in patients with stable ischemic heart disease, uncertainty surrounds the optimal revascularization strategy for patients with ST-elevation myocardial infarction (MI) and ULMCA occlusion who survive to hospitalization, and treatment guidelines in this setting are vague. Percutaneous coronary intervention (PCI) is technically feasible in most patients, has the advantage of providing more rapid reperfusion compared with CABG with acceptable short- and long-term outcomes, and is associated with a lower risk of stroke. PCI of the ULMCA should be considered as a viable alternative to CABG for selected patients with MI, including those with ULMCA occlusion and less than Thrombolysis In Myocardial Infarction flow grade 3, cardiogenic shock, persistent ventricular arrhythmias, and significant comorbidities. The higher risk of target vessel revascularization associated with ULMCA PCI compared with CABG is an acceptable tradeoff given the primary need for rapid reperfusion to enhance survival.
authors: UCLA Medical Center, Los Angeles, California 90095, USA. mslee@mednet.ucla.edu
authors: Michael S
authors: MS
authors: Lee
authors: Pooya
authors: P
authors: Bokhoor
authors: Seung-Jung
authors: SJ
authors: Park
authors: Young-Hak
authors: YH
authors: Kim
authors: Gregg W
authors: GW
authors: Stone
authors: Imad
authors: I
authors: Sheiban
authors: Giuseppe
authors: G
authors: Biondi-Zoccai
authors: Dario
authors: D
authors: Sillano
authors: Jonathan
authors: J
authors: Tobis
authors: David E
authors: DE
authors: Kandzari
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003324:Coronary Artery Disease / Q000150:complications / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D003326:Coronary Circulation; D019317:Evidence-Based Medicine; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome