[HLA-G: an immunoregulatory non classical class I HLA molecule].
HLA-G is a particular non classical HLA class I molecule. Despite its tissue-restricted expression and low polymorphism, this molecule plays an important role in innate and adaptative immunity. The tolerogenic propriety of HLA-G makes it an immunomodulatory molecule acting in the early phases of conception, protecting fetal tissues from the maternal immune system. Immunomodulatory functions of HLA-G and the associations of this molecule with some pathological states are reported in this review. So, little amounts of soluble HLA-G or particular allelic expression of this molecule are associated with some pregnancy complications. HLA-G expression on tumor cells by preventing antitumor responses via a trogocytosis mechanism and regulatory T cells induction is associated with invasiveness and clinical evolution of some tumor types. HLA-G is also involved in the protection of the transplanted tissues from rejection. Revealing of new more functional homomultimeric isoforms of this molecule offers new insight in a better understanding of clinical and biological role of HLA-G.
Ksouri
H
H
Service des Laboratoires, Centre National de Greffe de Moelle Osseuse 2, Rue Jebel Lakdha, 1006 Tunis. ksourih_2000@yahoo.fr
Bardi
R
R
Mellouli
F
F
Bejaoui
M
M
D056704:Adaptive Immunity / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D054502:Histocompatibility, Maternal-Fetal / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D056747:Immunomodulation / Q000276:immunology; D011110:Polymorphism, Genetic / Q000276:immunology; D011247:Pregnancy; D020033:Protein Isoforms / Q000276:immunology; D055503:Protein Multimerization / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology; D054346:Receptors, KIR2DL5; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms; D011971:Receptors, Immunologic; D054346:Receptors, KIR2DL5