Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins.
A tag-and-modify strategy allows the practical synthesis of homogenous fluorinated glyco-amino acids, peptides and proteins carrying a fluorine label in the sugar and allows access to first examples of directly radiolabelled ([(18)F]-glyco)proteins.
Boutureira
Omar
O
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.
D'Hooge
François
F
Fernández-González
Marta
M
Bernardes
Gonçalo J L
GJ
Sánchez-Navarro
Macarena
M
Koeppe
Julia R
JR
Davis
Benjamin G
BG
D005461:Fluorine / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry; D005643:Fucose / Q000031:analogs & derivatives / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry*
D005462:Fluorine Radioisotopes; D006023:Glycoproteins; D005461:Fluorine; D005643:Fucose; C049289:2-deoxy-2-fluorogalactose