title: Spinal epidural lipomatosis due to a bronchial ACTH-secreting carcinoid tumour.
abstract: Spinal epidural lipomatosis (SEL) is a rare condition characterized by abnormal deposits of fat in the epidural space. In a severe form this may cause compression of neural elements. This is the second report of SEL secondary to a carcinoid tumour. Our patient was a 34-year-old Caucasian male farm worker presenting with acute spinal cord compression. He had gained 11kg, and had developed Type II diabetes mellitus in the preceding 12months. On examination he displayed characteristic features of Cushing's syndrome. MRI demonstrated posterior epidural lipomatosis, with cord compression from T3 to T8. Urgent spinal cord decompression was performed. Further investigation confirmed a biochemical Cushing's syndrome secondary to an ACTH-producing pulmonary carcinoid tumour.
authors: Department of Neurosurgery, c/o Suite 712, St Vincents Clinic, St Vincent's Hospital, 438 Victoria Street, Darlinghurst, New South Wales 2010, Australia.
authors: K
authors: K
authors: Bhatia
authors: E
authors: E
authors: Frydenberg
authors: T
authors: T
authors: Steel
authors: M
authors: M
authors: Ow-Yang
authors: K
authors: K
authors: Ho
authors: E
authors: E
authors: Grainger
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000378:metabolism; D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003480:Cushing Syndrome / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008068:Lipomatosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D013117:Spinal Cord Compression / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000324:Adrenocorticotropic Hormone