Clinical significance of serum anti-annexin V antibodies in Egyptian patients with scleroderma.
The pathogenesis of scleroderma encompasses vascular, immunological, and fibrotic processes, which contribute to clinical manifestations. We investigated the prevalence of anti-annexin V IgG and IgM antibodies in sera of scleroderma patients and their relation to the presence of other antibodies and development of disease morbidity. Sera of 40 scleroderma patients and 15 healthy controls were examined for IgG and IgM anti-annexin V antibodies by ELISA and anticentromere antibodies by indirect immunofluorescence. Serum level of anti-annexin V IgG antibodies in scleroderma patients was significantly higher than that of the control (P < 0.001) and correlated significantly with the presence of digital ischemia (P = 0.023) and pulmonary fibrosis (P = 0.02). IgM isotype was comparable between patients and controls (P = 0.317). Anticentromere antibodies are more prevalent in the limited cutaneous subtype (P = 0.017). In conclusion, measurement of serum anti-annexin V IgG antibodies in scleroderma patients may be important for early diagnosis of vascular and pulmonary complications.
El Serougy
Iman M
IM
Department of Rheumatology & Rehabilitation, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
Shahin
Amira A
AA
Soliman
Doaa A
DA
Akhnoukh
Amany F
AF
Mousa
Somaia M
SM
D000328:Adult; D017304:Annexin A5 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D002503:Centromere / Q000276:immunology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D045743:Scleroderma, Diffuse / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000473:pathology
D017304:Annexin A5; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M