Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma.
Allergy history has been consistently inversely associated with glioma risk. Two serologic markers, soluble CD23 (sCD23) and soluble CD14 (sCD14), are part of the innate and adaptive humoral immune systems and modulate allergic responses in opposite directions, with sCD23 enhancing and sCD14 blunting inflammatory responses. We measured sCD23 and sCD14 in serum from blood that was drawn at a single time point from 1,079 glioma patients postdiagnosis and 736 healthy controls. Glioma was strongly associated with high sCD14 [highest versus lowest quartile odds ratio (OR), 3.94; 95% confidence interval (95% CI), 2.98-5.21] and low sCD23 (lowest versus highest quartile OR, 2.5; 95% CI, 1.89-3.23). Results were consistent across glioma histologic types and grades, but were strongest for glioblastoma. Whereas temozolomide treatment was not associated with either sCD14 or sCD23 levels among cases, those taking dexamethasone had somewhat lower sCD23 levels than those not taking dexamethasone. However, sCD23 was associated with case status regardless of dexamethasone treatment. These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis.
Zhou
Mi
M
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA.
Wiemels
Joseph L
JL
Bracci
Paige M
PM
Wrensch
Margaret R
MR
McCoy
Lucie S
LS
Rice
Terri
T
Sison
Jennette D
JD
Patoka
Joseph S
JS
Wiencke
John K
JK
D000328:Adult; D016022:Case-Control Studies; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005910:Glioma / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology; D007108:Immune Tolerance; D056724:Immunity, Humoral / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood* / Q000276:immunology; D000077204:Temozolomide; D055815:Young Adult
D018950:Lipopolysaccharide Receptors; D017455:Receptors, IgE; D007073:Immunoglobulin E; D003606:Dacarbazine; D003907:Dexamethasone; D000077204:Temozolomide