title: B lymphoblastic lymphoma presenting as a tumor of the nasopharynx in an adult patient.
abstract: In adults, non-Hodgkin's lymphoma (NHL) is the second most common neoplasm found in the head and neck region after squamous cell carcinoma. Within this region, primary NHL of the nasopharynx is rare. We report the case of a 28-year-old male diagnosed with a B lymphoblastic lymphoma (CD20-; CD79a+; CD3-; CD10+; PAX5+, CyclinD1-; TdT+) of the nasopharynx extending to the deep and superficial structures of the right hemiface, to the skull base with an intracranial component and a small but detectable bone marrow involvement, who was started on chemotherapy with a complete response. To the best of our knowledge, this is the first case of a primary nasopharynx B-LBL in an adult patient with such aggressive regional spread to be reported in the literature.
authors: Serviço de Hematologia, Hospital Santo António dos Capuchos, Alameda Santo António dos Capuchos, 1169-050 Lisbon, Portugal. ronolosi@gmail.com
authors: Rodrigo
authors: R
authors: Lopes da Silva
authors: Teresa
authors: T
authors: Fernandes
authors: Alexandra
authors: A
authors: Lopes
authors: Susana
authors: S
authors: Santos
authors: Manuela
authors: M
authors: Mafra
authors: António Silva
authors: AS
authors: Rodrigues
authors: Aida Botelho
authors: AB
authors: de Sousa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology*; D012074:Remission Induction