Evaluation of iodine, iron, and selenium in biological samples of thyroid mother and their newly born babies.
BACKGROUND
There is accumulating facts that the metabolism of essential trace elements is altered in thyroid patients.


OBJECTIVE
The aim of present study was to compare the status of essential trace elements, iodine, iron (Fe), and selenium (Se) in biological samples (serum and urine) of goitrous mothers (age ranged 30-40) and their newly born infants (n=76). An age matched 68 non-goitrous mothers and their infants, residing in the same locality, were selected as referents. For a comparative study, the biological samples of non-goitrous and goitrous pregnant and non pregnant female subjects of the same age group and socio-economic status were also analyzed.


METHODS
The Fe and Se concentrations in biological samples were determined by a flame and hydride generation atomic absorption spectrometry respectively, while iodine was measured by iodide-ion selective electrode, prior to microwave assisted acid digestion. The validity and accuracy of the methodology was checked by certified reference materials.


RESULTS
The mean values of iodine, Fe and Se in serum and urine samples of thyroid mothers and their infants were significantly lower as compared to the referent mothers-infants pairs (p<0.01).


CONCLUSIONS
The deficiencies of essential trace elements may adversely affect the health of women and their neonates.
Kazi
Tasneem Gul
TG
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. tgkazi@yahoo.com
Kandhro
Ghulam Abbas
GA
Sirajuddin
Afridi
Hassan Imran
HI
Baig
Jameel Ahmed
JA
Shah
Abdul Qadir
AQ
Wadhwa
Sham Kumar
SK
Khan
Sumaira
S
Kolachi
Nida Fatima
NF
Shaikh
Hafeez-ur-Rahman
HU
D000328:Adult; D001724:Birth Weight; D001774:Blood Chemical Analysis; D005260:Female; D006043:Goiter, Endemic / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007455:Iodine / Q000032:analysis / Q000378:metabolism*; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D012643:Selenium / Q000032:analysis / Q000378:metabolism*; D016482:Urinalysis
D007455:Iodine; D007501:Iron; D012643:Selenium