Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach.
We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg/mm(2) (40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM. Reactions are measured over time periods as long as 3 h with high stability.
Xu
D-X
DX
Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Ontario, Canada, K1A 0R6. Danxia.Xu@Nrc-cnrc.gc.ca
Vachon
M
M
Densmore
A
A
Ma
R
R
Delâge
A
A
Janz
S
S
Lapointe
J
J
Li
Y
Y
Lopinski
G
G
Zhang
D
D
Liu
Q Y
QY
Cheben
P
P
Schmid
J H
JH
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D002417:Cattle; D007074:Immunoglobulin G / Q000276:immunology; D055616:Microtechnology; D012710:Serum Albumin, Bovine / Q000032:analysis / Q000276:immunology; D012825:Silicon
D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine; D012825:Silicon