[Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor.].
BACKGROUND
Angiogenesis depends on the interaction of a variety of promoting factors and inhibiting factors. Vascular endothelial growth factor (VEGF) and Notch signaling pathway take part in this process. This experiment investigates the expression of Notch ligand DLL4 and VEGF in lung adenocarcinoma and their relationship with angiogenesis in tumor.


METHODS
Immunohistochemical method was used to detect DLL4, VEGF and CD34 protein expression in 80 cases of lung adenocarcinoma (including bronchioloalveolar carcinoma and common lung adenocarcinoma) paraffin section tissues.


RESULTS
The expression of DLL4 and VEGF was closely related to tumor diameter, clinical stage, histological grade and lymph node metastasis, the VEGF expression rate in DLL4 positive expression cases was significantly more than the DLL4 negative cases, the correlation between microvascular density and DLL4, VEGF co-expression was more significant, the expression of DLL4 in common lung adenocarcinoma was significantly higher than that in bronchioloalveolar carcinoma.


CONCLUSIONS
The prognosis of lung adenocarcinoma is significant correlated with the angiogenesis, high expression of DLL4 is closely related to the metastasis and the prognosis.
Li
Xiaoping
X
Department of Thoracic Surgery, China Medical University First Hospital, Shenyang 110001, China; Department of Thoracic Surgery, Tianjin First Central Hospital, Tianjin 300192, China.
Zhang
Qingfu
Q
Lu
Bin
B
Qiu
Xueshan
X
Luo
Yang
Y
Zhang
Weidong
W
Xu
Shun
S