title: [Changes of caspase-9 in rat retina caused by Nd:YAG laser injury].
abstract: OBJECTIVE
  To investigate the changes of caspase-9 in the retina of Long Evans rats caused by Nd: YAG laser injury.
  
  
  METHODS
  A model of retina injury in rats caused by Nd:YAG laser was established. The activity and the expression of mRNA and protein of caspase-9 were detected at Oh, 3h, 6h, 24h, 3d and 7d after laser irradiation. RESULTS; No conspicuous change of caspase-9 mRNA in retina was observed just after laser irradiation, but the activity of caspase-9 and the expression of caspase-9 mRNA and protein increased significantly at 6h and 12h after irradiation (P < 0.05).
  
  
  CONCLUSIONS
  Caspase-9 in the retina of LE rat was activated by Nd:YAG laser irradiation.
authors: Department of nutrition, General Hospital of Chinese PLA, Beijing 100853, China. aqing_930@163.com
authors: Qing
authors: Q
authors: Xu
authors: Aimin
authors: A
authors: Wei
authors: Yanwen
authors: Y
authors: Zhang
authors: Zhengping
authors: Z
authors: Yu
authors: Changyong
authors: C
authors: Xue
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D053453:Caspase 9 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D053844:Lasers, Solid-State / Q000009:adverse effects*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D051381:Rats; D020318:Rats, Long-Evans; D012160:Retina / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*
chemical_list: D012333:RNA, Messenger; C506435:Casp9 protein, rat; D053453:Caspase 9