Ubiquilin at a crossroads in protein degradation pathways.
Ubiquilin proteins are conserved across all eukaryotes and function in the regulation of protein degradation. We found that ubiquilin functions to regulate macroautophagy and that the protein is also a substrate of chaperone-mediated autophagy.
Rothenberg
Cara
C
Center for Biomedical Engineering and Technology, Department of Anatomy and Neurology, University of Maryland, Baltimore, Baltimore, MD, USA.
Monteiro
Mervyn J
MJ
D048868:Adaptor Proteins, Signal Transducing; D001343:Autophagy / Q000502:physiology; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; D018832:Molecular Chaperones; D011506:Proteins; D011993:Recombinant Fusion Proteins; C107792:UBQLN1 protein, human