Nuclear receptors, inflammation, and neurodegenerative diseases.
Chronic inflammation is associated with many neurodegenerative diseases, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Increasing evidence that neuroinflammation contributes to disease severity has generated considerable interest in determining whether inhibition of inflammation pathways might be of therapeutic benefit. One potential avenue of intervention is provided by members of the nuclear receptor superfamily of ligand-dependent transcription factors that exert anti-inflammatory effects in many cell types. Here, we review recent studies providing insights into the distinct mechanisms that enable nuclear receptors to modulate immune responses, describe inflammatory components of neurodegenerative diseases, and discuss recent literature relevant to roles of nuclear receptors in influencing these processes.
Saijo
Kaoru
K
Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Crotti
Andrea
A
Glass
Christopher K
CK
D056704:Adaptive Immunity; D000818:Animals; D001253:Astrocytes / Q000276:immunology; D002490:Central Nervous System / Q000166:cytology / Q000276:immunology*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000150:complications / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D017628:Microglia / Q000276:immunology; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000276:immunology; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism
D018160:Receptors, Cytoplasmic and Nuclear