title: Influence of fetal growth velocity and smallness at birth on adrenal function in adolescence.
abstract: The hypothalamic-pituitary-adrenal axis is susceptible to programming during fetal development and may be linked to risk of disease later in life. In a former prospective study the cohort was divided into those born appropriate for gestational age (AGA) or small for gestational age (SGA; birth weight <10 percentile). In 52 adolescent boys (17.5 years) we assessed circulating androgen levels (T, Δ(4)-adione, DHEAS), overnight serum cortisol profiles (every 20 min), ACTH stimulation test (250 μg i.v.) and analysis of 24-hour urinary adrenal steroid excretion. Urinary excretion of adrenal androgen and cortisol metabolites were significantly lower in the SGA compared to the AGA group. Basal morning cortisol levels were lower in adolescents born SGA compared to those born AGA (365 mmol/l, interquartile range (IQR) 284-413 vs. 445 mmol/l, IQR 377-495, p = 0.04), but overnight cortisol profiles (AUC) did not differ. The ACTH test showed equally stimulated levels of cortisol for those born SGA and AGA. There was no difference in serum testosterone, dehydroepiandrosterone sulfate and Δ(4)-adione levels between the SGA and AGA subjects. This suggests impaired excretion of adrenal androgen and cortisol metabolites in young men born SGA compared to AGA. In conclusion, this study demonstrated subtle changes in adolescent adrenal function associated with birth weight.
authors: University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. rikke.beck@dadlnet.dk
authors: Rikke
authors: R
authors: Beck Jensen
authors: Signe
authors: S
authors: Vielwerth
authors: Torben
authors: T
authors: Larsen
authors: Linda
authors: L
authors: Hilsted
authors: Arieh
authors: A
authors: Cohen
authors: David M
authors: DM
authors: Hougaard
authors: Lars Thorbjørn
authors: LT
authors: Jensen
authors: Gorm
authors: G
authors: Greisen
authors: Anders
authors: A
authors: Juul
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000503:physiopathology*; D000309:Adrenal Insufficiency / Q000209:etiology; D000728:Androgens / Q000378:metabolism / Q000652:urine; D000735:Androstenedione / Q000097:blood; D001724:Birth Weight; D002940:Circadian Rhythm; D015331:Cohort Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D047109:Fetal Development; D005317:Fetal Growth Retardation / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism / Q000652:urine; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood; D007700:Kinetics; D008137:Longitudinal Studies; D008297:Male; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone