Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction.
The hypothalamus plays an important role in maintaining a homeostasis of the body against stress response. In particular, the paraventricular nucleus of the hypothalamus is a critical region for disorders related to the autonomic nervous system, such as congestive heart failure and hypertension. αB-crystallin is a family of heat shock proteins that are widely expressed in the brain, including in glial cells, astrocytes, oligodendrocytes, and neurons. Many studies have demonstrated that expression level of αB-crystallin is up-regulated and involved in protecting cells from pathological conditions. In the present study, we examined the expression and potential role of αB-crystallin in the paraventricular nucleus (PVN) regions of rats with myocardial infarction (MI). Our results demonstrate that mRNA encoding αB-crystallin and protein for both native and phosphorylate forms (Ser-59) of αB-crystallin was significantly increased in the PVN during MI.
Jang
Soo Hwa
SH
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
Han
Tae Hee
TH
Hwang
In Koo
IK
Park
Seon Ah
SA
Kwak
Yong Geun
YG
Park
Jin Bong
JB
Han
Seong Kyu
SK
Ryu
Pan Dong
PD
Lee
So Yeong
SY
D000818:Animals; D003459:Crystallins / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D009203:Myocardial Infarction / Q000473:pathology*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D012333:RNA, Messenger; D051381:Rats; D017207:Rats, Sprague-Dawley; D012694:Serine / Q000378:metabolism
D003459:Crystallins; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger; C530883:cryaB protein, rat; D012694:Serine