Amelioration of radiation-induced hematological and biochemical alterations in Swiss albino mice by Panax ginseng extract.
BACKGROUND
This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver.


RESULTS
Radiation exposure resulted in a significant decline (P<.001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls.


CONCLUSIONS
From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.
Verma
Preeti
P
University of Rajasthan, Jaipur, India.
Sharma
Priyanka
P
Parmar
Jyoti
J
Sharma
Priyanka
P
Agrawal
Annapurna
A
Goyal
P K
PK
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D006400:Hematocrit; D006402:Hematologic Diseases / Q000209:etiology* / Q000517:prevention & control*; D006454:Hemoglobins / Q000378:metabolism / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; C519374:Panax notoginseng extract; D011837:Radiation-Protective Agents; D005978:Glutathione