title: Downstream of identity genes: muscle-type-specific regulation of the fusion process.
abstract: In all metazoan organisms, the diversification of cell types involves determination of cell fates and subsequent execution of specific differentiation programs. During Drosophila myogenesis, identity genes specify the fates of founder myoblasts, from which derive all individual larval muscles. Here, to understand how cell fate information residing within founders is translated during differentiation, we focus on three identity genes, eve, lb, and slou, and how they control the size of individual muscles by regulating the number of fusion events. They achieve this by setting expression levels of Mp20, Pax, and mspo, three genes that regulate actin dynamics and cell adhesion and, as we show here, modulate the fusion process in a muscle-specific manner. Thus, these data show how the identity information implemented by transcription factors is translated via target genes into cell-type-specific programs of differentiation.
authors: GReD, INSERM U, CNRS UMR, University of Clermont-Ferrand, France.
authors: Laetitia
authors: L
authors: Bataillé
authors: Isabelle
authors: I
authors: Delon
authors: Jean Philippe
authors: JP
authors: Da Ponte
authors: Nicholas H
authors: NH
authors: Brown
authors: Krzysztof
authors: K
authors: Jagla
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002459:Cell Fusion; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology* / Q000502:physiology*; D004625:Embryo, Nonmammalian / Q000033:anatomy & histology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins; D024510:Muscle Development / Q000502:physiology*; D032446:Myoblasts / Q000166:cytology / Q000502:physiology*; D051419:Paxillin / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; C496059:Pax protein, Drosophila; D051419:Paxillin; D010455:Peptides; C498957:mspo protein, Drosophila