Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat.
The objective of this study was to evaluate the peripheral expression of inflammatory markers in adolescents with different nutritional status and its correlation with parameters of the metabolic syndrome. Seventy-two female postpubescent adolescents were divided into 3 groups: eutrophic (Co), eutrophic with a high body fat percentage (HBF), and overweight (OW). Data related to the parameters of the metabolic syndrome and the peripheral expression of tumour necrosis factor (TNF)-&alpha;, interleukin (IL)-6, and IL-10 were evaluated. Higher values of glycemia and insulin resistance were found in the HBF group than in the Co group. No differences related to the peripheral expression of the cytokines were found among the groups. In the HBF group, a positive correlation was observed between TNF-&alpha; and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. In the OW group, a positive correlation was found between IL-6 and triglycerides. Adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents. This suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents. The positive correlation between IL-10 and TNF-&alpha; and IL-6 suggests an attempt to inhibit the production of these cytokines by IL-10.
Carvalho
Gisele Queiroz
GQ
Department of Nutrition and Health, Federal University of Viçosa (UFV), Viçosa, Minas Gerais 36570-000, Brazil.
Pereira
Patrícia Feliciano
PF
Serrano
Hiara Miguel Stancioli
HM
do Carmo Castro Franceschini
Sylvia
S
Oliveira de Paula
Sérgio
S
Priore
Silvia Eloiza
SE
do Carmo Gouveia Peluzio
Maria
M
D050154:Adiposity; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D001938:Brazil; D002318:Cardiovascular Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood*; D007333:Insulin Resistance; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D050177:Overweight / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055105:Waist Circumference
D015415:Biomarkers; D001786:Blood Glucose; C508609:IL10 protein, human; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10