title: Differential response of dystonia and parkinsonism following globus pallidus internus deep brain stimulation in X-linked dystonia-parkinsonism (Lubag).
abstract: BACKGROUND
  X-linked dystonia-parkinsonism (XDP; DYT3; Lubag) is an adult-onset hereditary progressive dystonia/parkinsonism which is typically minimally responsive to pharmacological treatment.
  
  
  METHODS
  We report a 63- year-old man with a diagnosis of XDP who underwent bilateral globus pallidus internus deep brain stimulator (GPi-DBS) placement. His course initially began with right hand tremor and dystonia at age 57 and progressed to also include bradykinesia and rigidity. The patient tolerated the procedure without significant complications. GPi-DBS improved his right hand dystonia, but did not significantly improve his parkinsonism.
  
  
  CONCLUSIONS
  DBS may be a therapeutic option for select cases of XDP, but its specific indications must be carefully discussed, as the available cases have had mixed responses. Whether other targets may be more effective is not known.
authors: Department of Neurology, University of Florida College of Medicine/Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA.
authors: Genko
authors: G
authors: Oyama
authors: Hubert H
authors: HH
authors: Fernandez
authors: Kelly D
authors: KD
authors: Foote
authors: Pam
authors: P
authors: Zeilman
authors: Nelson
authors: N
authors: Hwynn
authors: Charles E
authors: CE
authors: Jacobson
authors: Irene A
authors: IA
authors: Malaty
authors: Ramon L
authors: RL
authors: Rodriguez
authors: Michael S
authors: MS
authors: Okun
mesh_terms: D046690:Deep Brain Stimulation; D004421:Dystonia / Q000628:therapy*; D040181:Genetic Diseases, X-Linked / Q000628:therapy*; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000628:therapy*; D016896:Treatment Outcome