title: Long Term Effects of Energy-Restricted Diets Differing in Glycemic Load on Metabolic Adaptation and Body Composition.
abstract: A randomized controlled trial of high glycemic load (HG) and low glycemic load (LG) diets with food provided for 6 months and self-administered for 6 additional months at 30% caloric restriction (CR) was performed in 29 overweight adults (mean+/-SD, age 35+/-5y; BMI 27.5+/-1.5 kg/m(2)). Total energy expenditure (TEE), resting metabolic rate (RMR), fat and fat free mass (FFM), were measured at 3, 6 and 12 months. Changes in TEE, but not changes in RMR, were greater than accounted for by the loss of FFM and fat mass (P=0.001-0.013) suggesting an adaptive response to long-term CR. There was no significant effect of diet group on change in RMR or TEE. However, in subjects who lost >5% body weight (n=26), the LG diet group had a higher percentage of weight loss as fat than the HG group (p<0.05), a finding that may have implications for dietary recommendations during weight reduction.
authors: Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors: Sai Krupa
authors: SK
authors: Das
authors: Cheryl H
authors: CH
authors: Gilhooly
authors: Julie K
authors: JK
authors: Golden
authors: Anastassios G
authors: AG
authors: Pittas
authors: Paul J
authors: PJ
authors: Fuss
authors: Gerard E
authors: GE
authors: Dallal
authors: Megan A
authors: MA
authors: McCrory
authors: Edward
authors: E
authors: Saltzman
authors: Susan B
authors: SB
authors: Roberts