title: Level of kidney function correlates with cognitive decline.
abstract: BACKGROUND
  Early stage chronic kidney disease has been related to cognitive decline recently, while the association between them has never been explored in a Chinese population.
  
  
  METHODS
  This prospective study included a 1,351 community-based Chinese population >40 years and with estimated glomerular filtration rate (eGFR) >30 ml/min/ 1.73 m(2). Kidney function was assessed by eGFR at baseline; cognitive function was evaluated by Mini-Mental State Examination (MMSE) both at baseline and 4 years later, and MMSE score decreased < or =2 was defined as cognitive decline using analysis of Reliable Change Indices. There were 1,243 participants (92.0%) with valid data of MMSE at the second visit.
  
  
  RESULTS
  Altogether there were 66 (5.3%) incident cognitive decline cases during 4 years of follow-up. After adjusting for potential confounders including urinary albumin-to-creatinine ratio, the odds ratio of developing cognitive decline was 1.35 (95% CI 0.69-2.65) among participants with eGFR 60-89 ml/min/1.73 m(2) and was 2.73 (95% CI 1.00-7.56) among participants with eGFR 30-59 ml/min/1.73 m(2), compared to those with eGFR > or =90 ml/min/1.73 m(2).
  
  
  CONCLUSIONS
  Our prospective study suggests that kidney function is associated with a cognitive decline in a Chinese population and the relation is independent of urinary albumin excretion.
authors: Institute of Nephrology, Peking University First Hospital, Beijing, China.
authors: Fang
authors: F
authors: Wang
authors: Luxia
authors: L
authors: Zhang
authors: Lisheng
authors: L
authors: Liu
authors: Haiyan
authors: H
authors: Wang
mesh_terms: D000368:Aged; D000419:Albuminuria; D044466:Asian People; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012307:Risk Factors