Research with rTMS in the treatment of aphasia.
This review of our research with rTMS to treat aphasia contains four parts: Part 1 reviews functional brain imaging studies related to recovery of language in aphasia with emphasis on nonfluent aphasia. Part 2 presents the rationale for using rTMS to treat nonfluent aphasia patients (based on results from functional imaging studies). Part 2 also reviews our current rTMS treatment protocol used with nonfluent aphasia patients, and our functional imaging results from overt naming fMRI scans, obtained pre- and post- a series of rTMS treatments. Part 3 presents results from a pilot study where rTMS treatments were followed immediately by constraint-induced language therapy (CILT). Part 4 reviews our diffusion tensor imaging (DTI) study that examined white matter connections between the horizontal, midportion of the arcuate fasciculus (hAF) to different parts within Broca's area (pars triangularis, PTr; pars opercularis, POp), and the ventral premotor cortex (vPMC) in the RH and in the LH. Part 4 also addresses some of the possible mechanisms involved with improved naming and speech, following rTMS with nonfluent aphasia patients.
Naeser
Margaret A
MA
Veterans Affairs Boston Healthcare System and the Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, Boston, MA 02130, USA. mnaeser@bu.edu
Martin
Paula I
PI
Treglia
Ethan
E
Ho
Michael
M
Kaplan
Elina
E
Bashir
Shahid
S
Hamilton
Roy
R
Coslett
H Branch
HB
Pascual-Leone
Alvaro
A
D000818:Animals; D001037:Aphasia / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D001039:Aphasia, Broca / Q000523:psychology / Q000628:therapy; D038524:Diffusion Magnetic Resonance Imaging; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D007808:Language Therapy; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000473:pathology; D009483:Neuropsychological Tests; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome