A novel degradable polymeric carrier for selective release and imaging of magnetic nanoparticles.
A water-soluble, pH-responsive copolymer was synthesized successfully and used as a polymeric carrier to deliver hydrophobic paramagnetic nanoparticles into cells. In an acidic environment, the nanoparticles aggregate as the copolymer degrades, resulting in the enhancement of an in vitro MRI signal.
Chen
Dongyun
D
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China 215123.
Li
Najun
N
Gu
Hongwei
H
Xia
Xuewei
X
Xu
Qingfeng
Q
Ge
Jianfeng
J
Lu
Jianmei
J
Li
Yonggang
Y
D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*
D003287:Contrast Media; D005290:Ferric Compounds; D011108:Polymers; C000499:ferric oxide