Asymmetric synthesis of functionalized, monocyclic chlorocyclobutenes.
The selective synthesis of a variety of stereopure monocyclic chlorocyclobutenes is described. These derivatives could be coupled with Grignard reagents; two dienes from coupling with vinylmagnesium bromide reacted smoothly with maleic anhydride to yield illudol-related [4 + 2] cycloadducts.
Darses
Benjamin
B
Département de Chimie Moléculaire (SERCO) UMR-5250, ICMG FR-2607, CNRS Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France.
Greene
Andrew E
AE
Poisson
Jean-François
JF