title: Effects of feeding diets contaminated with Fusarium mycotoxins on blood biochemical parameters of broiler chickens.
abstract: This study was conducted to investigate the effects of deoxynivalenol (DON) and zearalenone (ZEA) on some biochemical indices of broiler chickens. Twenty-four Ross 308 hybrid broiler chickens of both sexes were fed diets containing maize contaminated with Fusarium mycotoxins. The diets included a control diet (DON 0.60 mg/kg feed; ZEA 0.07 mg/kg feed), an experimental 1 diet (DON 3.4 mg kg⁻¹ feed; ZEA 3.4 mg kg⁻¹ feed), and an experimental 2 diet (DON 8.2 mg kg⁻¹ feed; ZEA 8.3 mg kg⁻¹ feed). Contaminated diets were fed from 14 days of age for 14 days. Blood samples were collected from 4-week-old birds. Chicks fed a diet containing a low level of contaminated maize (experimental 1) had decreased plasma potassium, magnesium, phosphorus, total protein, albumin, triglycerides, free glycerol concentrations and increased cholesterol and calcium levels as well as alkaline phosphatase (ALP) and aspartate aminotransferase (AST) enzyme activities as compared to the control. Feeding a diet contaminated with high levels of mycotoxins (experimental 2) resulted in decreased plasma potassium, magnesium, total protein, albumin, triglycerides, free glycerol concentrations and increased plasma ALP, alanine aminotransferase (ALT) and AST enzyme activities. The effect of mycotoxin-contaminated diets on ALP activity was dose dependent. Chloride concentration was not affected by the diets. It can be concluded that feeding diets contaminated with both levels of Fusarium mycotoxins significantly affected protein, lipid and mineral metabolism as well as AST and ALP enzyme activities in broiler chickens.
authors: University of Veterinary Medicine, Komenského 73, 04181 Kosice, Slovak Republic. faixova@uvm.sk
authors: Zita
authors: Z
authors: Faixová
authors: Stefan
authors: S
authors: Faix
authors: Radka
authors: R
authors: Borutová
authors: Lubomír
authors: L
authors: Leng
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000418:Albumins / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001798:Blood Proteins; D002645:Chickens / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004032:Diet / Q000662:veterinary*; D005260:Female; D005506:Food Contamination; D005670:Fusarium; D005990:Glycerol / Q000097:blood; D008297:Male; D011188:Potassium / Q000097:blood; D014255:Trichothecenes / Q000737:chemistry / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood; D015025:Zearalenone / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000418:Albumins; D001798:Blood Proteins; D014255:Trichothecenes; D014280:Triglycerides; D015025:Zearalenone; D002784:Cholesterol; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; C007262:deoxynivalenol; D005990:Glycerol; D011188:Potassium