title: [Performance of a portable continuous infusion pump (SUREFUSER A) in continuous infusion of 5-FU].
abstract: Therapy with mFOLFOX6/FOLFIRI used in treating colorectal cancer is typical of the regimens performed in outpatient settings. In this therapy, 46-h continuous infusion of 5-fluorouracil (5-FU) with concomitant oxaliplatin and irinotecan hydrochloride is conducted. The portable continuous infusion pump that makes continuous infusion possible has a non-electric structure, so variation in the infusion rate is seen. There are known effects of 5-FU concentration and temperature, and many studies have reported on the precision. In our hospital, we have experienced many cases of incomplete infusion and delays for the above reasons. We changed the specifications of the infusion pump to correspond to the kinematic viscosity of 5-FU and made all drug solution amounts uniform. We measured the time required to administer the drug solution from the time the infusion was started (recorded by a nurse) and the time it was completed (recorded by the patient), and confirmed the precision of the pump after the changes were made. It was found that while there was a decrease in the infusion rate at which the effect of the kinematic viscosity of 5-FU is seen, the mean infusion time was kept to within 46+/-10% hours in more than 90% of patients. There were no effects from concentration differences in 5-FU, and the completion time was reduced. The management and lifestyles of individual patients are potential factors in precision errors, and it is important to explain in advance to patients the necessity of secure fixation and infusion pump problems that might occur.
authors: Dept. of Pharmacy, Nagoya Daini Red Cross Hospital.
authors: Tsukasa
authors: T
authors: Kimata
authors: Eiji
authors: E
authors: Sakamoto
authors: Aya
authors: A
authors: Kawachi
authors: Yayoi
authors: Y
authors: Takahashi
authors: Asako
authors: A
authors: Kuroki
authors: Masashi
authors: M
authors: Nakamura
authors: Yoshihiro
authors: Y
authors: Kawade
authors: Kenji
authors: K
authors: Tokui
authors: Tatsuya
authors: T
authors: Suzuki
authors: Takashi
authors: T
authors: Oyama
authors: Toshiki
authors: T
authors: Uchida
authors: Tomonori
authors: T
authors: Yamada
authors: Masahiro
authors: M
authors: Kondoh
authors: Michinori
authors: M
authors: Ogura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D005472:Fluorouracil