title: The role of Ca(2+) in ultrasound-elicited bioeffects: progress, perspectives and prospects.
abstract: Intracellular calcium (Ca(2+)) transients have been observed in association with exposure to therapeutic ultrasound and correlated to both early- and late-onset bioeffects. For example, it has been suggested that early 'ultra-short' Ca(2+) transients recorded during sonoporation can mediate Ca(2+)-dependent exocytosis and endocytosis processes as complementary mechanisms for membrane self-sealing. Moreover, apoptosis induction has been reported to occur through a partial mediation of a Ca(2+)-dependent pathway. In this review, we attempt to assemble the salient facts into a cogent whole, with special attention given to the relationships arising through altered Ca(2+) levels, which underscore its crucial role during ultrasonic interactions with biological systems and its consequent implications in the context of therapeutics.
authors: Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan.
authors: Mariame A
authors: MA
authors: Hassan
authors: Paul
authors: P
authors: Campbell
authors: Takashi
authors: T
authors: Kondo
mesh_terms: D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D008564:Membrane Potentials; D010539:Permeability; D015398:Signal Transduction; D014464:Ultrasonic Therapy; D014945:Wound Healing / Q000502:physiology
chemical_list: D002118:Calcium