A new allele, HLA-B*4212, identified in a Brazilian volunteer bone marrow donors by sequence-based typing.
Here we report the discovery of a novel HLA-B allele, named B*4212 in a Brazilian volunteer bone marrow donor. The new sequence has nucleotide variation at position 496 (T→G) as compared with B*4201. This variation results in a conservative amino acid substitution from valine to glycine at codon 165 of exon 3.
Mattar
S B
SB
Laboratory of Immunogenetics and Histocompatibility, Genetics Department, Universidade Federal do Paraná, Curitiba, Brazil.
Uehara
C J S
CJ
Ribas
F
F
Vargas
R G
RG
Wowk
P F
PF
Poerner
F
F
Bicalho
M G
MG
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D001853:Bone Marrow; D001938:Brazil; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D014019:Tissue Donors
D015235:HLA-B Antigens