CD3- and CD4-positive plasmablastic lymphoma: a literature review of Japanese plasmablastic lymphoma cases.
Plasmablastic lymphoma (PBL) is a very rare and recently-described subtype of diffuse large B-cell lymphoma. A maxillary tumor in an 84-year-old HIV-negative Japanese-man was referred. The biopsied specimen showed a diffuse proliferation of mature plasma cells, expressing CD3 (+), CD4 (+), CD20 (-), CD138 (+) and EBER (+) by immunohistochemistry. He was diagnosed as a plasmablastic lymphoma; radiation therapy (RT) was started, but the response to the RT was only a partial response. To our knowledge, this is the first report of a patient with PBL expressing CD3 and CD4.
Suzuki
Yuhko
Y
Department of Hematology, Kitasato University School of Medicine, Sagamihara, Japan. ysuzuki-hki@umin.ac.jp
Yoshida
Tsutomu
T
Nakamura
Naoya
N
Kamata
Hirotoshi
H
Kotani
Shouko
S
Ohsaka
Manabu
M
Kajita
Sabine
S
Miyazaki
Koji
K
Ohtani
Shinichi
S
Nakayama
Meijin
M
Horie
Ryouichi
R
Hayakawa
Kazushige
K
Niitsu
Nozomi
N
Higashihara
Masaaki
M
D000369:Aged, 80 and over; D044466:Asian People; D017252:CD3 Complex / Q000096:biosynthesis*; D015704:CD4 Antigens / Q000096:biosynthesis*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism*; D008297:Male
D017252:CD3 Complex; D015704:CD4 Antigens