Copper-catalyzed aminobromination/elimination process: an efficient access to alpha,beta-unsaturated vicinal haloamino ketones and esters.
A novel copper-catalyzed aminobromination-elimination process has been developed, which provides an easy access to alpha,beta-unsaturated vicinal haloamindes derivatives from readily available alpha,beta-unsaturated ketones and esters in good to excellent yields. The isolated intermediate discloses that the current system proceeds through the aminobromination process.
Sun
Hao
H
School of Chemistry and Chemical Engineering; State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
Zhang
Guangqian
G
Zhi
Sanjun
S
Han
Jianlin
J
Li
Guigen
G
Pan
Yi
Y
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D054879:Halogenation; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular
D000475:Alkenes; D004952:Esters; D007659:Ketones; D003300:Copper