title: Serum levels of the adipokine zinc-α2-glycoprotein are increased in chronic hemodialysis.
abstract: Zinc-α2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight control. In the current study, we investigated renal elimination of this adipokine by comparing circulating ZAG levels in patients on chronic hemodialysis (CD) with controls. Sixty CD patients and 60 controls with a glomerular filtration rate greater than 50 mL/min were included. Serum concentrations of ZAG were determined by enzyme-linked immunosorbent assay; and its relationship with renal function, glucose and lipid metabolism, as well as inflammation was studied in both groups. Median ZAG serum levels were almost 2-fold higher in CD patients (94.4 ± 29.4 mg/L) as compared with controls (48.3 ± 23.5 mg/L) (P < .001). Furthermore, circulating ZAG was negatively correlated with fasting insulin, homeostasis model assessment of insulin resistance, and leptin in controls in univariate analysis. Moreover, CD independently predicted ZAG concentrations in multiple regression analysis. Renal filtration appears to be an important route of ZAG elimination, and markers of renal function should be included in studies on ZAG physiology.
authors: Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany.
authors: Anne
authors: A
authors: Philipp
authors: Susan
authors: S
authors: Kralisch
authors: Anette
authors: A
authors: Bachmann
authors: Ulrike
authors: U
authors: Lossner
authors: Jürgen
authors: J
authors: Kratzsch
authors: Matthias
authors: M
authors: Blüher
authors: Michael
authors: M
authors: Stumvoll
authors: Mathias
authors: M
authors: Fasshauer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005215:Fasting / Q000378:metabolism / Q000502:physiology; D005260:Female; D005919:Glomerular Filtration Rate; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007668:Kidney / Q000503:physiopathology; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D029589:Seminal Plasma Proteins / Q000097:blood*; D000090203:Zn-Alpha-2-Glycoprotein
chemical_list: D007328:Insulin; D020738:Leptin; D029589:Seminal Plasma Proteins; D000090203:Zn-Alpha-2-Glycoprotein; D005947:Glucose