Association between higher serum fetuin-A concentrations and abnormal albuminuria in middle-aged and elderly chinese with normal glucose tolerance.
OBJECTIVE
To study the association of serum fetuin-A as a potential risk factor with abnormal albuminuria in Chinese individuals with normal glucose tolerance (NGT).


METHODS
The cross-sectional analysis included 607 men and 1,042 women aged 40 or older with NGT.


RESULTS
Women with combined microalbuminuria and macroalbuminuria (n=68) had significantly higher serum fetuin-A concentrations than those with normal albumin excretion (n=974) (314.3 vs. 280.4 mg/l, P=0.007). Compared with the lowest quartile, the highest quartile of serum fetuin-A had 40% increased risk of abnormal albuminuria after the multiple adjustments in women (Pfor trend=0.02). However, the associations were not detected in men.


CONCLUSIONS
Higher serum fetuin-A was associated with abnormal albuminuria independent of BMI, waist circumference, homeostasis model assessment of insulin resistance, blood pressure, and other determinants of albuminuria in middle-aged and elderly Chinese women with NGT.
Li
Mian
M
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Xu
Min
M
Bi
Yufang
Y
Song
Aiyun
A
Liu
Yu
Y
Li
Xiaoying
X
Ning
Guang
G
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000503:physiopathology*; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D001798:Blood Proteins / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein