Resistance to activated protein C and ischemic arterial disease in a young man.
The assessment of activated protein C resistance (APCR) caused by mutations in factor V (factor V Leiden) is an important risk factor for venous thromboembolism, of which role as the originator of arterial obstructions in situ is still a controversial subject. The clinical case of a young patient with history of coronariopathy, multiple cerebrovascular lesions and peripheral artery disease is reported. The diagnostic investigation showed APCR as the possible etiology.
Menezes
Igor Alexandre Côrtes de
IA
Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Romani
Rafael Fernandes
RF
Aoki
Yuki Schneider
YS
Abdo
João Caetano
JC
Carvalho
Mauricio
M
D020016:Activated Protein C Resistance / Q000150:complications*; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000209:etiology; D002545:Brain Ischemia / Q000209:etiology*; D003327:Coronary Disease / Q000209:etiology*; D005165:Factor V / Q000235:genetics; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000209:etiology*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000209:etiology*
C095381:factor V Leiden; D005165:Factor V