title: Emerging insights in the management of hemoglobin E beta thalassemia.
abstract: Globally, hemoglobin (Hb) E beta thalassemia accounts for approximately half the severe forms of beta thalassemia. Because of its wide clinical diversity and the ability of patients with this condition to adapt unusually well to low hemoglobin levels, the management of Hb E beta thalassemia, particularly the decision to instigate regular blood transfusion, is particularly difficult. Here, we present a summary of our work in patients with this condition, which attempts to define clinical, adaptive, and genetic factors of possible value in determining the early management of this condition.
authors: Hemoglobinopathy Research Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. noliv@attglobal.net
authors: Nancy F
authors: NF
authors: Olivieri
authors: Vivekanandan
authors: V
authors: Thayalsuthan
authors: Angela
authors: A
authors: O'Donnell
authors: Anuja
authors: A
authors: Premawardhena
authors: Christopher
authors: C
authors: Rigobon
authors: Giulia
authors: G
authors: Muraca
authors: Christopher
authors: C
authors: Fisher
authors: David J
authors: DJ
authors: Weatherall
mesh_terms: D001803:Blood Transfusion; D006446:Hemoglobin E; D006801:Humans; D017086:beta-Thalassemia / Q000503:physiopathology / Q000628:therapy*
chemical_list: D006446:Hemoglobin E