title: Elective open versus laparoscopic sigmoid colectomy for diverticular disease: a meta-analysis with the Sigma trial.
abstract: BACKGROUND
  A meta-analysis of published literature comparing open versus laparoscopic elective sigmoid resections for diverticular disease was conducted.
  
  
  METHODS
  Electronic databases were searched for data from January 1991 to March 2009. A systematic review was performed to obtain a summative outcome.
  
  
  RESULTS
  Twenty-two comparative studies involving 10,898 patients were analyzed; 1538 patients were in the laparoscopic group and 9360 were in the open group. The operative time for laparoscopic sigmoid resection (LSR) is longer than open resections (OSR) [random-effects model: SMD = 1.94, 95% CI = (1.14, 2.74), z = 4.74, p < 0.001]. However, patients who undergo LSR have earlier return to passage of feces [random-effects model: SMD = -1.01, 95% CI (-1.80, -0.22), z = -2.50, p = 0.013] and shorter hospital stay [random-effects model: SMD = -7.65, 95% CI (-10.96, -4.32), z = -4.52, p < 0.001]. Overall morbidity was higher in the OSR group [random-effects model: RR = 0.56, 95% CI (0.40, 0.80), z = -3.24, p < 0.001] and no difference in mortality rates was observed (p = 0.81).
  
  
  CONCLUSIONS
  Laparoscopic sigmoid resection takes longer to perform than open procedures; however, it is safe and has lower overall morbidity, earlier return of bowel function, and shorter hospital stays. This approach should be considered for elective cases but more randomized controlled trials are required to strengthen the evidence.
authors: Department of Colorectal Surgery, Worthing Hospital, Washington Suite, North Wing, West Sussex, BN11 2DH, UK. md0u812a@mac.com
authors: Muhammed R S
authors: MR
authors: Siddiqui
authors: Muhammed S
authors: MS
authors: Sajid
authors: Kamran
authors: K
authors: Khatri
authors: Elizabeth
authors: E
authors: Cheek
authors: Mirza K
authors: MK
authors: Baig
mesh_terms: D003082:Colectomy / Q000379:methods; D043963:Diverticulosis, Colonic / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D012810:Sigmoid Diseases / Q000601:surgery*