Lucknolides A and B, tricyclic ketal-lactone metabolites from a terrestrial Streptomyces sp.
In a screening of micro-organisms for new secondary metabolites, two unprecedented tricyclic highly functionalized ketal-lactone metabolites, named lucknolide A (1) and lucknolide B (2), have been isolated, and the compounds were characterized by extensive NMR and mass spectroscopic studies. Single-crystal X-ray diffraction experiments on 1 and 2 were performed, and the absolute configuration of 1 was determined.
Yadav
Prem P
PP
Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Nair
Vimal
V
Dittrich
Birger
B
Schüffler
Anja
A
Laatsch
Hartmut
H
D018360:Crystallography, X-Ray; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
D007783:Lactones; C553540:lucknolide A; C553541:lucknolide B