Treatment of salivary mucocele of the lower lip by OK-432.
OBJECTIVE
The aim of this paper was to evaluate the outcome and complications of the treatment of patients with salivary mucocele by intralesional injection therapy with OK-432.


METHODS
We tried OK-432 therapy in 20 patients with salivary mucocele. We injected OK-432 solution into the lesion with a 27-gauge needle to prevent any leakage of the agent from the mucocele.


RESULTS
Disappearance of the lesion was observed in 16 of 20 patients. Marked reduction was observed in 4 of 20 patients. No local scarring or deformity of the lower lip occurred in any patients. As side effects, local discomfort at the injection site was observed in two of the patients, but such problems resolved within a few days. We performed this treatment on an outpatient basis without hospitalization.


CONCLUSIONS
Our results confirmed that OK-432 therapy is simple, easy, and relatively safe, and can be used as a substitute for surgery in the treatment of salivary mucocele.
Ohta
Nobuo
N
Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan. noohta@med.id.yamagata-u.ac.jp
Fukase
Shigeru
S
Suzuki
Yusuke
Y
Aoyagi
Masaru
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008047:Lip Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009078:Mucocele / Q000188:drug therapy*; D010844:Picibanil / Q000008:administration & dosage*; D012466:Salivary Gland Diseases / Q000188:drug therapy*; D012470:Salivary Glands, Minor; D055815:Young Adult
D000970:Antineoplastic Agents; D010844:Picibanil