Terpenes from the soft corals Litophyton arboreum and Sarcophyton ehrenbergi.
The new cembrane diterpene (3E,11E)-cembra-3,8(19),11,15-tetraene-7alpha-ol (1), nephthenol (2), and all-trans-peridinin (3) have been isolated from the soft coral Litophyton arboreum. The tetraterpene 3, (+)-7,8-epoxy-7,8-dihydrocembrene C (4), emblide (5), sarcophytoxide (6), sarcoglaucol-16-one (7), guajacophine (8), and 1,4-peroxymuurol-5-ene (9) have been obtained from the soft coral Sarcophyton ehrenbergi. The compounds were characterized primarily by NMR spectroscopy. Some of the terpenes were tested for their antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa, and they showed moderate activities.
Shaker
Kamel H
KH
Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, D-95440 Bayreuth.
Müller
Michael
M
Ghani
M Abdel
MA
Dahse
Hans-Martin
HM
Seifert
Karlheinz
K
D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000145:classification*; D000970:Antineoplastic Agents / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy; D013729:Terpenes / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification
D000970:Antineoplastic Agents; D013729:Terpenes