Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine.
The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid. The key step involves the alkylation of a glycine-enolate equivalent.
Braun
Manfred
M
Institute of Organic and Macromolecular Chemistry, University of Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany. braunm@uni-duesseldorf.de
Dittrich
Torsten
T