Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition.
Described is the construction of the N-methylwelwitindolinone C core via an efficient strategy that employs a sequential rhodium carbenoid-mediated O-H insertion, Claisen rearrangement and transannular [3+2] nitrone cycloaddition.
Freeman
David B
DB
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Holubec
Alexandra A
AA
Weiss
Matthew W
MW
Dixon
Julie A
JA
Kakefuda
Akio
A
Ohtsuka
Masami
M
Inoue
Munenori
M
Vaswani
Rishi G
RG
Ohki
Hidenori
H
Doan
Brian D
BD
Reisman
Sarah E
SE
Stoltz
Brian M
BM
Day
Joshua J
JJ
Tao
Ran N
RN
Dieterich
Noah A
NA
Wood
John L
JL