title: Effects of propofol and isoflurane anesthesia on the intraocular pressure and hemodynamics of pigs.
abstract: To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isoflurane, and (3) 2 h after topical administration of bimatoprost or (4) timolol. Propofol/ketamine and isoflurane induced significant decreases in the IOP. The pulsation of the ophthalmic artery appeared at a significantly higher IOP in animals anesthetized with isoflurane than in those anesthetized with propofol/ketamine. Bimatoprost and timolol did not significantly decrease the IOP within 2 h after topical administration. It is concluded that different techniques for the acute noninvasive investigation of ocular hydro- and hemodynamics are applicable in anesthetized pigs. To test the effects of antiglaucoma agents, investigation periods longer than 2 h are required. We recommend the use of intravenous propofol/ketamine anesthesia rather than isoflurane anesthesia in future experiments using pigs.
authors: Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany. Eva.Buehner@medizin.uni-leipzig.de
authors: Eva
authors: E
authors: Buehner
authors: Uta-Carolin
authors: UC
authors: Pietsch
authors: Andreas
authors: A
authors: Bringmann
authors: Christian
authors: C
authors: Foja
authors: Peter
authors: P
authors: Wiedemann
authors: Susann
authors: S
authors: Uhlmann
mesh_terms: D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D019162:Anesthetics, Combined / Q000494:pharmacology; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007429:Intraocular Pressure / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D015742:Propofol / Q000494:pharmacology*; D034421:Sus scrofa; D014065:Tonometry, Ocular
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000959:Antihypertensive Agents; D007649:Ketamine; D007530:Isoflurane; D015742:Propofol