[Flavonoids and phenolic acid derivatives from flos farfarae].
OBJECTIVE
To investigate the chemical constituents of the flower buds of Tussilago farfara.


METHODS
The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography, and structurally elucidated by spectral evidence together with physiochemical properties.


RESULTS
Seven flavonoids, quercetin (1), quercetin-3-O-beta-D-glucopyranoside (2), quercetin-4'-O-beta-D-glucopyranoside (3), hyperoside (4), rutin (5), kaempferol (6), kaempferol-3-O-alpha-L-rhamnopyranosyl-(1-6)-beta-D-glucopyranoside (7), together with eight phenolic acid derivatives, caffeic acid (8), methyl caffeate (9), ethyl caffeate (10), (E)-2,5-dihydroxycinnamic acid (11), 3,4-di-O-caffeoylquinic acid (12), 4,5-di-O-caffeoylquinic acid (13), methyl4,5-di-O-caffeoylquinate (14) and chlorogenic acid (15) were isolated from the flower buds of Tussilago farfara.


CONCLUSIONS
Compounds 7, 9-14 are isolated from this plant, also from this genus, for the first time.
Wu
Di
D
Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing 211198, China.
Zhang
Mian
M
Zhang
Chaofeng
C
Wang
Zhengtao
Z
D005419:Flavonoids / Q000032:analysis* / Q000302:isolation & purification; D035264:Flowers / Q000737:chemistry; D062385:Hydroxybenzoates / Q000032:analysis* / Q000302:isolation & purification; D010936:Plant Extracts / Q000032:analysis* / Q000302:isolation & purification; D031207:Tussilago / Q000737:chemistry*
D005419:Flavonoids; D062385:Hydroxybenzoates; D010936:Plant Extracts; C017616:phenolic acid