title: [Effect of plant polysaccharides on TH1-dependent immune response: screening investigation].
abstract: We have studied the influence of water-soluble polysaccharides isolated from Tussilago farfara L. leaves, Betula verrucosa Ehrh. leaves, Calendula officinalis L. flowers, Acorus calamus rhizomes, Inula helenium L. rhizomes, overground part of Trifolium pretense L., and overground part ofArtemisia absinthium L., on Thl immune response induced by sheep red blood cells and on NO production by murine peritoneal macrophages in vitro. All the investigated polysaccharides have stimulated a Th1 response. Polysaccharides isolated from Betula verrucosa leaves did not influence NO synthesis, while polysaccharides of Tussilago farfara leaves and Acorus calamus rhizomes stimulated NO synthase of murine macrophages on a level comparable with that of lipopolysaccharides (LPS). Polysaccharides from Inula helenium rhizomes, Calendula officinalis flowers, and overground parts of Trifolium pretense and Artemisia absinthium also stimulated NO production, but to a lower extent in comparison to LPS.
authors: M G
authors: MG
authors: Danilets
authors: Iu P
authors: IuP
authors: Bel'skiĭ
authors: A M
authors: AM
authors: Gur'ev
authors: M V
authors: MV
authors: Belousov
authors: N V
authors: NV
authors: Bel'skaia
authors: E S
authors: ES
authors: Trofimova
authors: E G
authors: EG
authors: Uchasova
authors: R R
authors: RR
authors: Alhmedzhanov
authors: A A
authors: AA
authors: Ligacheva
authors: M S
authors: MS
authors: Iusbov
authors: V I
authors: VI
authors: Agefonov
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000096:biosynthesis / Q000276:immunology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000276:immunology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D012756:Sheep; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase