Evolution of clinical proteomics and its role in medicine.
Significant progress has been made in characterizing and sequencing genomic alterations of biospecimens from several types of cancer. Understanding the functional changes in the human proteome that arise from the genomic alterations or other factors is the next logical step in the development of high-value protein biomarkers that can be transitioned to clinical studies for biomarker qualification. Linking advances in genomic analysis to proteomic analysis will provide a pathway for qualified biomarkers which can drive the rational development of new diagnostics and therapies. The availability of these multidimensional data to the scientific community sets the stage for the development of new molecularly targeted cancer interventions.
Boja
Emily
E
Office of Cancer Clinical Proteomics Research, Center for Strategic Scientific Initiative, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Hiltke
Tara
T
Rivers
Robert
R
Kinsinger
Christopher
C
Rahbar
Amir
A
Mesri
Mehdi
M
Rodriguez
Henry
H
D015510:Clinical Medicine; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D040901:Proteomics