title: Exertional heatstroke: early recognition and outcome with aggressive combined cooling--a 12-year experience.
abstract: OBJECTIVE
  To determine the clinical outcomes of an aggressive combined cooling technique for exertional heatstroke in Thailand.
  
  
  METHODS
  We analyzed patients who were diagnosed with exertional heatstroke between 1995 and 2007. Outcomes were assessed both in hospital and at 3 months follow-up.
  
  
  RESULTS
  Twenty-eight cases of exertional heatstroke presented to Phramongkutklao Army Hospital over 12 years. All patients developed multiorgan dysfunction and encephalopathy. Twenty-four cases had acute renal failure, 7 of whom required dialysis. Disseminated intravascular coagulation (DIC) was detected in 9 patients (32.1%). In-hospital mortality was 7.1%. Most survivors recovered with nearly normal organ function. However, 9 exhibited prolonged neurologic dysfunction and 2 had chronic renal dysfunction requiring hemodialysis. At 3-month follow-up, neurologic and renal dysfunction in those patients persisted. Higher serum prothrombin time and DIC correlated to fatality. The patients whose core body temperature achieved 38 degrees C within 3 hours revealed a significantly lower DIC and twice as low in the frequency of poor outcome than the patients cooled longer than 3 hours to reduce core body temperature to 38 degrees C.
  
  
  CONCLUSIONS
  Despite early recognition and aggressive combined cooling, exertional heatstroke remains associated with multiorgan dysfunction. However, our 7.1% in-hospital mortality rate was low compared to previous studies. Early diagnosis and prompt treatment are critical.
authors: Division of Neurology, Department of Medicine, Phramongkutklao Army Hospital and Medical College, Bangkok, 10400, Thailand.
authors: Pasiri
authors: P
authors: Sithinamsuwan
authors: Kunchit
authors: K
authors: Piyavechviratana
authors: Thitisak
authors: T
authors: Kitthaweesin
authors: Watcharapong
authors: W
authors: Chusri
authors: Patima
authors: P
authors: Orrawanhanothai
authors: Adisorn
authors: A
authors: Wongsa
authors: Anan
authors: A
authors: Wattanathum
authors: Yotin
authors: Y
authors: Chinvarun
authors: Samart
authors: S
authors: Nidhinandana
authors: Bancha
authors: B
authors: Satirapoj
authors: Ouppatham
authors: O
authors: Supasyndh
authors: Chantrapa
authors: C
authors: Sriswasdi
authors: Wichai
authors: W
authors: Prayoonwiwat
mesh_terms: D000328:Adult; D001831:Body Temperature; D016009:Chi-Square Distribution; D003080:Cold Temperature; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D018883:Heat Stroke / Q000150:complications / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D017052:Hospital Mortality; D006772:Hospitals, Military; D006801:Humans; D008297:Male; D008887:Military Medicine / Q000379:methods*; D005082:Physical Exertion; D018709:Statistics, Nonparametric; D013785:Thailand; D016896:Treatment Outcome