title: The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages.
abstract: OBJECTIVE
  The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages.
  
  
  METHODS
  Eighty adolescent boys were grouped (n=20) as; Group1: obese-Tanner2, Group2: non-obese-Tanner2, Group3: obese-Tanner4, Group4: non-obese-Tanner4. Serum INSL3, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, estradiol, sex hormone binding globulin, inhibin B and leptin levels were assessed in all groups.
  
  
  RESULTS
  INSL3 levels were significantly lower in obese adolescents compared to non-obese boys (p=0.003, Tanner2) and (p=0.031, Tanner4). There was a negative correlation between INSL3 and leptin (r=-0.468, p=0.001). The negative correlation between INSL3 and BMISDS indicates that pubertal obesity leads to Leydig cell impairment.
  
  
  CONCLUSIONS
  This study demonstrated for the first time in the literature that obesity effects testicular Leydig cell function starting from Tanner stage 2.
authors: Department of Clinical Biochemistry, Celal Bayar University, Faculty of Medicine, Manisa, Turkey. fatmataneli@superonline.com
authors: Fatma
authors: F
authors: Taneli
authors: Betul
authors: B
authors: Ersoy
authors: Bayram
authors: B
authors: Ozhan
authors: Mehmet
authors: M
authors: Calkan
authors: Omer
authors: O
authors: Yılmaz
authors: Gönül
authors: G
authors: Dinç
authors: Abdulkadir
authors: A
authors: Genç
authors: Can
authors: C
authors: Taneli
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D007265:Inhibins / Q000097:blood*; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D011506:Proteins; D011627:Puberty / Q000097:blood*; D013737:Testis / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood
chemical_list: D007328:Insulin; D020738:Leptin; C084797:Leydig insulin-like protein; D011506:Proteins; C422364:inhibin B; D013739:Testosterone; D007265:Inhibins; D007986:Luteinizing Hormone