The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues.
We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats' paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE(2) in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE(2). Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions.
Kassim
Mustafa
M
Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. zoobeadi@yahoo.com
Achoui
Mouna
M
Mansor
Marzida
M
Yusoff
Kamaruddin Mohd
KM
D000818:Animals; D015232:Dinoprostone / Q000037:antagonists & inhibitors*; D006722:Honey / Q000032:analysis*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D008296:Malaysia; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009569:Nitric Oxide; D015232:Dinoprostone