title: [Blue Light-Filtering IOLs - Currently available data].
abstract: Data from both experimental and epidemiological trials have suggested a potential correlation between extraction of the natural lens associated with exposure to photo-oxidative stress to the retina and a progression of diseases such as AMD. A fundamental factor could be the unchecked exposure to blue light. This is why in the past years so-called blue light-filtering intraocular lenses have been implanted to serve as a protection to the retina. The following contribution is based on a data base research (Pub Med, National Library of Medicine, USA) and summarises information currently available on the use of blue light-filtering lenses. Experimental modeling has shown that, compared to regular UV lenses, blue light-filtering lenses block a considerable part of blue light transmission to the retina and reduce damage to retinal cells and production of inflammatory markers such as VEGF. The majority of the clinical data demonstrate that blue light-filtering lenses are compatible in terms of visual acuity, contrast sensitivity and colour perception as well as patient-rated quality of vision. But a few additional studies report reduced contrast sensitivity and limitations in mesopic vision.This is also true for the circadian rhythm. However, the evaluation of this parameter in connection with blue light-filtering lenses has only been done on a theoretical basis. Long-term data showing that blue light-filtering lenses actually do reduce the incidence of retinal diseases such as AMD are currently not available.
authors: Augenklinik, Klinikum Karlsruhe. albertjaugustin@googlemail.com
authors: A J
authors: AJ
authors: Augustin
mesh_terms: D002940:Circadian Rhythm; D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007910:Lenses, Intraocular; D008027:Light / Q000009:adverse effects*; D008268:Macular Degeneration / Q000517:prevention & control*; D017060:Patient Satisfaction; D011183:Postoperative Complications / Q000517:prevention & control*; D011474:Prosthesis Design; D011835:Radiation Protection / Q000295:instrumentation*; D012160:Retina / Q000528:radiation effects*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D042461:Vascular Endothelial Growth Factor A