Prothrombotic state, cardiovascular, and metabolic syndrome risk factors in prepubertal children born large for gestational age.
OBJECTIVE
To evaluate metabolic syndrome and cardiovascular disease risk factors in prepubertal children born large for gestational age (LGA) to nondiabetic, nonobese mothers.


METHODS
At 6-7 years of age, the comparison of various factors was made between 31 LGA and 34 appropriate-for-gestational-age (AGA) children: fibrinogen, antithrombin III, protein C and S, fasting insulin, glucose, homeostasis assessment model of insulin resistance (HOMA-IR) index, adiponectin, leptin, visfatin, IGF-1, IGF-binding protein (IGFBP)-1, IGFBP-3, lipids, and the genetic factors V Leiden G1691A mutation, prothrombin 20210A/G polymorphism, and mutation in the enzyme 5,10-methylenetetrahydrofolate-reductase gene (MTHFR-C677T).


RESULTS
LGA children had higher levels of leptin (P<0.01), fasting insulin (P<0.01), and HOMA-IR (P<0.01), but lower IGFBP-3 (P=0.0001), fibrinogen (P=0.0001), and lipoprotein(a) (P<0.001) than AGA children. Significantly more LGA children were homozygous for the MTHFR-C677T mutation (P=0.0016).


CONCLUSIONS
Being born LGA to nondiabetic, nonobese mothers is associated with diverse effects on cardiometabolic risk factors at prepuberty.
Evagelidou
Eleni N
EN
Neonatal Intensive Care Unit, University Hospital of Ioannina, University of Ioannina, Ioannina, Greece.
Giapros
Vasileios I
VI
Challa
Anna S
AS
Cholevas
Vasileios K
VK
Vartholomatos
Georgios A
GA
Siomou
Ekaterini C
EC
Kolaitis
Nikolaos I
NI
Bairaktari
Eleni T
ET
Andronikou
Styliani K
SK
D001724:Birth Weight / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D012044:Regression Analysis; D013927:Thrombosis / Q000453:epidemiology*