title: Prospective memory deficits in patients with bipolar disorder: a preliminary study.
abstract: Prospective memory (PM) is the ability to remember to do something in the future without explicit prompts. To date, little has been known about PM deficits in bipolar disorder (BD). This study examined the nature and correlates of PM in patients with BD. Forty clinically stable BD patients and 40 matched healthy controls formed the study sample. Socio-demographic characteristics, PM, psychosocial functioning, retrospective memory (RM), and IQ were measured in all participants, whereas clinical condition was measured in patients with standardized assessment instruments. Patients performed significantly more poorly on the time-based PM task than controls (10.6 ± 5.0 vs. 14.6 ± 3.0, p < .001). In correlation analyses, older age, lower education, more severe depressive and manic symptoms, poor psychosocial functioning, poor RM, and lower scores in IQ were significantly associated with poor performance in the time-based PM task, whereas poor RM and lower scores in IQ associated with poorer performance in the event-based PM task in patients. In multivariate analyses, severity of depression and older age significantly contributed to poor performance in the time-based PM task, whereas poor RM contributed to poor performance in the event-based PM task in patients. The time-based PM is impaired in BD patients. Depressive symptoms, age, and RM were determinants of certain aspects of impaired PM performance in BD patients.
authors: Department of Psychiatry, Chinese University of Hong Kong, China.
authors: Edwin
authors: E
authors: Lee
authors: Yu-Tao
authors: YT
authors: Xiang
authors: David
authors: D
authors: Man
authors: Raymond W C
authors: RW
authors: Au
authors: David
authors: D
authors: Shum
authors: Wai-Kwong
authors: WK
authors: Tang
authors: Helen F K
authors: HF
authors: Chiu
authors: Pinki
authors: P
authors: Wong
authors: Gabor S
authors: GS
authors: Ungvari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000150:complications*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012307:Risk Factors; D013997:Time Factors