Microarray-based comparative genomic hybridization (array-CGH) as a useful tool for identifying genes involved in Glioblastoma (GB).
Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of Glioblastomas (GBs). Microarray-based comparative genomic hybridization (array-CGH) is a high-throughput technology that allows the hybridization of genomic DNA onto conventional cDNA microarrays, normally used in expression profiling, to analyze genomic copy number imbalances. In this way, thousands of genes can be reviewed in a high resolution analysis to define amplicons and to identify? candidate genes showing recurrent genomic copy number changes in GB tumors.
Ruano
Yolanda
Y
Molecular Pathology Research Unit, Virgen de la Salud Hospital, Toledo, Spain.
Mollejo
Manuela
M
de Lope
Angel Rodríguez
AR
Hernández-Moneo
José Luis
JL
Martínez
Pedro
P
Meléndez
Bárbara
B
D001932:Brain Neoplasms / Q000235:genetics*; D055028:Comparative Genomic Hybridization / Q000379:methods*; D052138:Genes, Neoplasm; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011237:Predictive Value of Tests