Facile synthesis of bicyclic amidines and imidazolines from 1,2-diamines.
A facile synthesis of chiral bicyclic amidines and imidazolines from readily available 1,2-diamines has been developed. The reported synthetic strategy relies on an intramolecular cyclization which involves a carboxylic amide derived imidoyl chloride as a key intermediate and aniline serving as a leaving group.
Zhu
Qiang
Q
Department of Chemistry and Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.
Lu
Yixin
Y
D000578:Amidines / Q000138:chemical synthesis*; D000596:Amino Acids / Q000737:chemistry; D003959:Diamines / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis*; D048288:Imidazolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
D000578:Amidines; D000596:Amino Acids; D003959:Diamines; D006574:Heterocyclic Compounds, 2-Ring; D048288:Imidazolines