Myokymia and neuromyotonia in 37 Jack Russell terriers.
The clinical and clinicopathological characteristics, treatment and outcome of vermicular muscle contractions (myokymia) and generalized muscle stiffness (neuromyotonia) in 37 Jack Russell terriers were evaluated retrospectively. Thirty dogs were affected by both disorders, whereas seven were presented with myokymia and never developed neuromyotonia. Clinical signs started at the mean age of 8 months. Except for signs of myokymia and neuromyotonia, clinical and neurological examination was normal in all dogs. Thirty dogs demonstrated typical signs of hereditary ataxia. Changes in serum chemistry included increased creatine kinase, aspartate aminotransferase and alanine aminotransferase concentrations. Electromyographic abnormalities, especially in muscles showing macroscopically visible myokymia, consisted of semirhythmic bursts of doublet, triplet, or multiplet discharges of a single motor unit. The amplitudes varied between 80 μV and 1 mV and occurred with an interburst frequency between 10 and 40 Hz and an intraburst frequency between 150 and 280 Hz. Most dogs were treated with a sodium channel blocker with variable results. Seven dogs died (most likely because of hyperthermia) or were euthanased during a neuromyotonic attack; 15 dogs were euthanased due to worsening of clinical signs, or lack of or no long-lasting effect of medication, and three were euthanased for unknown or unrelated reasons. Nine dogs were lost to follow-up and three were still alive 5-10.5 years after the start of clinical signs. In conclusion, young Jack Russell terriers with myokymia and neuromyotonia should undergo a complete blood and electrophysiological examination. Long-term prognosis is not favourable.
Bhatti
Sofie F
SF
Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Sofie.Bhatti@UGent.be
Vanhaesebrouck
An E
AE
Van Soens
Iris
I
Martlé
Valentine A
VA
Polis
Ingeborgh E
IE
Rusbridge
Clare
C
Van Ham
Luc M
LM
D000818:Animals; D001530:Belgium; D001774:Blood Chemical Analysis / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D004576:Electromyography / Q000662:veterinary; D005260:Female; D005500:Follow-Up Studies; D020386:Isaacs Syndrome / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D020385:Myokymia / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies; D016896:Treatment Outcome