title: Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists.
abstract: A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
authors: Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot 20, Sector 18, Gurgaon 122015, Haryana, India. ab_rehman@rediffmail.com
authors: Abdul
authors: A
authors: Rehman
authors: Ajay
authors: A
authors: Soni
authors: Keshav
authors: K
authors: Naik
authors: Sreeji
authors: S
authors: Nair
authors: Venkata P
authors: VP
authors: Palle
authors: Sunanda
authors: S
authors: Dastidar
authors: Abhijit
authors: A
authors: Ray
authors: M S
authors: MS
authors: Alam
authors: Mohammad
authors: M
authors: Salman
authors: Ian A
authors: IA
authors: Cliffe
authors: Viswajanani
authors: V
authors: Sattigeri
mesh_terms: D002460:Cell Line; D004148:Dioxolanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008958:Models, Molecular; D011485:Protein Binding / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D004148:Dioxolanes; D039041:Integrin alpha4beta1; C010962:formal glycol