title: Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33.
abstract: Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2-3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.
authors: National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
authors: Muhammad Hashim
authors: MH
authors: Raza
authors: Sheikh
authors: S
authors: Riazuddin
authors: Dennis
authors: D
authors: Drayna
mesh_terms: D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003241:Consanguinity; D005192:Family Health; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D010154:Pakistan; D010375:Pedigree; D013342:Stuttering / Q000235:genetics*