Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach.
Major Jourden
Jody L
JL
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Cohen
Seth M
SM
D001812:Blood-Brain Barrier / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism*; D053508:Matrix Metalloproteinase 12 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism
C554580:1,2-HOPO-2 cpd; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D011355:Prodrugs; D011728:Pyridones; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D020782:Matrix Metalloproteinases; D020780:Matrix Metalloproteinase 9; D053508:Matrix Metalloproteinase 12