Effect of goniothalamin on the development of Ehrlich solid tumor in mice.
In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself.
Vendramini-Costa
Débora Barbosa
DB
Programa de Pós-graduação em Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil.
de Castro
Ilton Barros Daltro
IB
Ruiz
Ana Lúcia Tasca Góis
AL
Marquissolo
Cilene
C
Pilli
Ronaldo Aloise
RA
de Carvalho
João Ernesto
JE
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002351:Carrageenan / Q000633:toxicity; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D051379:Mice; D011753:Pyrones / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D013237:Stereoisomerism
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D011753:Pyrones; C103280:goniothalamin; D002351:Carrageenan