title: Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.
abstract: This study was conducted to analyze a comprehensive panel of single nucleotide polymorphisms (SNP) in DNA repair genes to determine the relationship between polymorphisms and the survival outcome of patients with early stage non-small-cell lung cancer (NSCLC). Three hundred and ten consecutive patients with surgically resected NSCLC were enrolled. Forty-eight SNP in 27 DNA repair genes were genotyped and their associations with overall survival (OS) and disease-free survival (DFS) were analyzed. Individually, six SNP exhibited significant associations with survival outcome. When the six SNP were combined, OS and DFS decreased as the number of bad genotypes increased (P(trend) <0.0001 for both). Patients with three, and four or five bad genotypes had a significantly worse OS and DFS compared with those carrying zero or one bad genotypes (adjusted hazard ratio [aHR] for OS=3.53, 95% confidence interval [CI]=1.25-9.97, P=0.02, and aHR for DFS=3.31, 95% CI=1.41-7.76, P=0.006; and aHR for OS=5.47, 95% CI=1.87-16.00, P=0.002, and aHR for DFS=4.42, 95% CI=1.82-10.74, P=0.001, respectively). These findings suggest that the six SNP identified can be used as prognostic markers for patients with surgically resected early stage NSCLC.
authors: Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea.
authors: Min
authors: M
authors: Kim
authors: Hyo-Gyoung
authors: HG
authors: Kang
authors: Shin Yup
authors: SY
authors: Lee
authors: Hyung Cheol
authors: HC
authors: Lee
authors: Eung Bae
authors: EB
authors: Lee
authors: Yi Young
authors: YY
authors: Choi
authors: Won Kee
authors: WK
authors: Lee
authors: Sukki
authors: S
authors: Cho
authors: Guang
authors: G
authors: Jin
authors: Hyo-Sung
authors: HS
authors: Jheon
authors: Ji Woong
authors: JW
authors: Son
authors: Myung-Hoon
authors: MH
authors: Lee
authors: Deuk Kju
authors: DK
authors: Jung
authors: Seung Ick
authors: SI
authors: Cha
authors: Chang Ho
authors: CH
authors: Kim
authors: Young Mo
authors: YM
authors: Kang
authors: Sin
authors: S
authors: Kam
authors: Tae Hoon
authors: TH
authors: Jung
authors: Sanghoon
authors: S
authors: Jheon
authors: Jae Yong
authors: JY
authors: Park
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D015254:DNA Modification Methylases / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009367:Neoplasm Staging; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D025521:Tumor Suppressor Proteins / Q000235:genetics; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C086984:XPC protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human; D045643:DNA Repair Enzymes