Low frequency of intermittent HIV-1 semen excretion in patients treated with darunavir-ritonavir at 600/100 milligrams twice a day plus two nucleoside reverse transcriptase inhibitors or monotherapy.
HIV-1 RNA level and darunavir concentration in the genital tract were measured in 45 men receiving darunavir-ritonavir mono- or tritherapy. At week 48, a low frequency (3/45) of HIV-1 RNA shedding was observed in patients (1 on monotherapy and 2 on triple therapy), although they had undetectable HIV-1 RNA in plasma. The median darunavir seminal plasma concentration was close to the blood plasma free fraction, demonstrating a good penetration of darunavir into the male genital tract.
Lambert-Niclot
Sidonie
S
Department of Virology, Pitié-Salpêtrière Hospital, 83 Boulevard de l'Hôpital, Paris, France.
Peytavin
Gilles
G
Duvivier
Claudine
C
Poirot
Catherine
C
Algarte-Genin
Michèle
M
Pakianather
Sophie
S
Meynard
Jean-Luc
JL
Valantin
Marc-Antoine
MA
Molina
Jean-Michel
JM
Flandre
Philippe
P
Katlama
Christine
C
Calvez
Vincent
V
Marcelin
Anne-Geneviève
AG
D000069454:Darunavir; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D008297:Male; D010949:Plasma / Q000737:chemistry; D012367:RNA, Viral / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D019438:Ritonavir / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D012661:Semen / Q000737:chemistry; D013449:Sulfonamides / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*
D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D013449:Sulfonamides; D019438:Ritonavir; D000069454:Darunavir