Dual energy CT at the synchrotron: a piglet model for neurovascular research.
BACKGROUND
Although the quality of imaging techniques available for neurovascular angiography in the hospital environment has significantly improved over the last decades, the equipment used for clinical work is not always suited for neurovascular research in animal models. We have previously investigated the suitability of synchrotron-based K-edge digital subtraction angiography (KEDSA) after intravenous injection of iodinated contrast agent for neurovascular angiography in radiography mode in both rabbit and pig models. We now have used the KEDSA technique for the acquisition of three-dimensional images and dual energy CT.


METHODS
All experiments were conducted at the biomedical beamline ID 17 of the European Synchrotron Radiation Facility (ESRF). A solid state germanium (Ge) detector was used for the acquisition of image pairs at 33.0 and 33.3 keV. Three-dimensional images were reconstructed from an image series containing 60 single images taken throughout a full rotation of 360°. CT images were reconstructed from two half-acquisitions with 720 projections each.


RESULTS
The small detector field of view was a limiting factor in our experiments. Nevertheless, we were able to show that dual energy CT using the KEDSA technique available at ID 17 is suitable for neurovascular research in animal models.
Schültke
Elisabeth
E
University of Saskatchewan, Saskatoon, SK, Canada. e.schultke@usask.ca
Kelly
Michael E
ME
Nemoz
Christian
C
Fiedler
Stefan
S
Ogieglo
Lissa
L
Crawford
Paul
P
Paterson
Jessica
J
Beavis
Cole
C
Esteve
Francois
F
Brochard
Thierry
T
Renier
Michel
M
Requardt
Herwig
H
Dallery
Dominique
D
Le Duc
Geraldine
G
Meguro
Kotoo
K
D015901:Angiography, Digital Subtraction / Q000379:methods*; D000818:Animals; D002533:Cerebral Angiography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D005857:Germanium; D021621:Imaging, Three-Dimensional; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives; D023421:Models, Animal; D011817:Rabbits; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media; D005857:Germanium; C093233:iobitridol; D007472:Iohexol