Bioinspired fabrication of 3D hierarchical porous nanomicrostructures of calcium carbonate for bone regeneration.
Hierarchical calcium carbonate structures with multi-scale organization have been successfully fabricated covering the full range of pore sizes from nano-, to micro- to macrofeatures. The resulting 3D scaffolds, with a close resemblance to bone structures, have been evaluated in vitro and in vivo and showed great potential for bone regeneration.
Yu
Hai-Dong
HD
Institute of Materials Research and Engineering, A-STAR, Singapore 117602.
Zhang
Zhi-Yong
ZY
Win
Khin Yin
KY
Chan
Jerry
J
Teoh
Swee Hin
SH
Han
Ming-Yong
MY
D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002119:Calcium Carbonate / Q000737:chemistry*; D002460:Cell Line; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity
D018786:Bone Substitutes; D002119:Calcium Carbonate