title: Discrimination ability of ASDAS estimating disease activity status in patients with ankylosing spondylitis.
abstract: OBJECTIVE
  To investigate discrimination ability of the Assessment of Spondyloarthritis International Society (ASAS) endorsed disease activity score (ASDAS) versions evaluating low and high disease activity in an unselected group of patients with ankylosing spondylitis (AS).
  
  
  METHODS
  Patients consecutively included into the joint database of five university hospitals were analyzed for low or high disease activity according to different criteria. Standardized mean differences (SMD) for two ASDAS versions were evaluated.
  
  
  RESULTS
  The ASDAS versions (back pain, morning stiffness, patient global pain, pain/swelling of peripheral joints, plus either erythrocyte sedimentation rate or C-reactive protein) discriminated high and low disease activity in subgroups according to Bath Ankylosing Spondylitis Disease Activity Score (BASDAI) and ASAS remission/partial remission criteria. ASDAS versions were also not influenced by peripheral arthritis and correlated well with other outcome measurements and acute-phase reactants. The ASDAS versions performed better than patient-reported measures or acute-phase reactants discriminating high and low disease activity status.
  
  
  CONCLUSIONS
  Both ASDAS versions, consisting of both patient-reported data and acute-phase reactants, performed well in discriminating low and high disease activity. Further longitudinal data may better estimate the usefulness of ASDAS to assess disease activity subgroups and treatment response.
authors: Department of Physical Medicine and Rehabilitation (PMR), Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Kemal
authors: K
authors: Nas
authors: Kadir
authors: K
authors: Yildirim
authors: Remzi
authors: R
authors: Cevik
authors: Saliha
authors: S
authors: Karatay
authors: Akin
authors: A
authors: Erdal
authors: Ozlem
authors: O
authors: Baysal
authors: Zuhal
authors: Z
authors: Altay
authors: Ayhan
authors: A
authors: Kamanli
authors: Yuksel
authors: Y
authors: Ersoy
authors: Arzu
authors: A
authors: Kaya
authors: Bekir
authors: B
authors: Durmus
authors: Ozge
authors: O
authors: Ardicoglu
authors: Ibrahim
authors: I
authors: Tekeoglu
authors: Mahir
authors: M
authors: Ugur
authors: Aysegul Jale
authors: AJ
authors: Sarac
authors: Kazim
authors: K
authors: Senel
authors: Ali
authors: A
authors: Gur
authors: Salih
authors: S
authors: Ozgocmen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D019992:Databases as Topic; D016002:Discriminant Analysis; D005260:Female; D006305:Health Status Indicators; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011788:Quality of Life; D057566:Self Report; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014421:Turkey
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein