title: Chitosan modification and pharmaceutical/biomedical applications.
abstract: Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand--D-Glucosaminic acid from oxidation of D-Glucosamine for cancer and diabetes therapy.
authors: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China. 9989card@163.com
authors: Jiali
authors: J
authors: Zhang
authors: Wenshui
authors: W
authors: Xia
authors: Ping
authors: P
authors: Liu
authors: Qinyuan
authors: Q
authors: Cheng
authors: Talba
authors: T
authors: Tahirou
authors: Wenxiu
authors: W
authors: Gu
authors: Bo
authors: B
authors: Li
mesh_terms: D000818:Animals; D002686:Chitin / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005944:Glucosamine / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D009844:Oligosaccharides / Q000737:chemistry; D012995:Solubility
chemical_list: D004337:Drug Carriers; D009844:Oligosaccharides; D002686:Chitin; C035547:glucosaminic acid; D048271:Chitosan; D005944:Glucosamine