Partial status epilepticus induced by hypocupremia in a patient with Wilson's disease.
Although seizures are rarely encountered in Wilson's disease (WD), seizures related to hypocupremia have not been reported before. We report a patient presenting with partial status epilepticus who was on strict low-copper diet and chelating therapy for WD. Despite other rare causes of seizures in WD including penicillamine-induced pyridoxine deficiency, cerebral copper deposition and metabolic encephalopathy, the most probable cause of resistant status epilepticus in this patient was found as hypocupremia from overzealous treatment. This case exemplifies that hypocupremic states should be kept in mind as a risk factor for resistant seizures.
Benbir
Gulcin
G
Cerrahpasa Faculty of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey. drgulcinbenbir@yahoo.com
Gunduz
Aysegul
A
Ertan
Sibel
S
Ozkara
Cigdem
C
D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003300:Copper / Q000097:blood / Q000172:deficiency*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
D003300:Copper; D010396:Penicillamine