A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han.
MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) in pre-miRNA may be biomarkers for biomedical applications. In this study, we performed a genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility in a case-control study. We found that the homozygote CC of this SNP increased the risk of ESCC compared with the homozygote TT and the risk was more evident among smokers than non-smokers. Therefore, this functional SNP may be a biomarker for ESCC outcome.
Wang
Kai
K
Department of Basic Medicine, Third Military Medical University, Chongqing, PR China.
Guo
Hong
H
Hu
Huamei
H
Xiong
Gang
G
Guan
Xingying
X
Li
Juan
J
Xu
Xueqing
X
Yang
Kang
K
Bai
Yun
Y
D000368:Aged; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged
D017931:DNA Primers; C542543:MIRN196 microRNA, human; D035683:MicroRNAs