First direct comparison of platelet reactivity and thrombolytic status between Japanese and Western volunteers: possible relationship to the "Japanese paradox".
OBJECTIVE
To determine and compare thrombotic and endogenous thrombolytic status in Japanese and Western populations.


BACKGROUND
Incidence of coronary heart disease (CHD) and AMI in Japan remains lower than in Western countries. Primary genetic effects are unlikely, given the increased CHD in Japanese migrants. For men, cholesterol and blood pressure have been similar in Japan and the U.S. Dietary factors are implicated, but how these effect CHD is unclear. We postulated that differences in thrombotic and/or thrombolytic status may contribute.


METHODS
We measured thrombotic and thrombolytic status in 100 healthy Japanese (J) from Japan and 100 healthy Westerners (W) from the U.K. using the Global Thrombosis Test (GTT). The GTT employs non-anticoagulated blood to create platelet-rich thrombi under high shear (occlusion time OT; seconds), and then measures the restart of blood flow, due to spontaneous thrombolysis (lysis time LT; seconds).


RESULTS
OT was longer in (J) compared to (W) (545 vs. 364, p<0.0001). LT was longer in (J) than in (W) (1753 vs. 1052, p<0.0001). Distribution of LT in (J) did not conform to a normal population, with markedly impaired thrombolytic status (LT>3,000 s) in 18%, compared to none of the Westerners (p<0.0001).


CONCLUSIONS
There are marked differences in thrombotic and thrombolytic status, with (J) having less prothrombotic (longer OT) but less favourable endogenous thrombolytic profile (longer LT). This may be important in the aetiology of thrombotic events. Since platelets and thrombolysis were both inhibited in (J) and yet incidence of AMI is lower, OT would seem more important than LT as a determinant of overall thrombotic risk in this population.
Gorog
Diana A
DA
Imperial College, London, UK. d.gorog@imperial.ac.uk
Yamamoto
Junichiro
J
Saraf
Smriti
S
Ishii
Hiromitsu
H
Ijiri
Yoshinobu
Y
Ikarugi
Hideo
H
Wellsted
David M
DM
Mori
Mari
M
Yamori
Yukio
Y
D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D001780:Blood Coagulation Tests / Q000379:methods* / Q000706:statistics & numerical data; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015539:Platelet Activation / Q000502:physiology*; D012307:Risk Factors; D013314:Stress, Mechanical; D013927:Thrombosis / Q000097:blood / Q000208:ethnology / Q000503:physiopathology; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult