[Effects of MVP regimen on operation and cancer tisswes of Lung Cancer patients.].
BACKGROUND
Preoperative chemotherapy increases the difficulty and risk of patients' operation. The aim of this study is to analyze the change of thoracic tissue, study the influence of chemotherapy to operation, discuss the special aspects of surgical management and observe the pathological change of focus after chemotherapy.


METHODS
100 patients were chosen and randomly divided into two groups(operation first group, 50 cases; chemotherapy first group, 50 cases) . Some patient's pathological sections were observed to investigate focus morphological influence of preoperative chemotherapy and the clinical response rate were compared with pathological response rate.


RESULTS
It was showed that preoperative chemotherapy conduced different degree thoracic tissue fibrosis. Data statistics demonstrated that there were no significance difference of the operation time, blood loss during operation and drainage volume in first day after operation between two groups. The preoperative chemotherapy increased the difficulty of operation because of tissue fibrosis and scarification, but the risk could be avoided by skillful operation. In first operation group, there were various pathological changes in tumor tissue and the pathological response rate was not completely accordance with the clinical response rate. The focus pathological response rate of two cycles chemotherapy was more higher than that of one cycle chemotherapy.


CONCLUSIONS
IDO Chemotherapy increases the risks of operation. Surgeons carefulness and better skills during operation are the key points to avoid the hazards of surgery. Two preoperative chemotherapy cycles are more suitable for the patients.
Shentu
Yang
Y
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai lung tumor clinical medical center, Shanghai 200030,China.
Zheng
Min
M
Chen
Gang
G
Ding
Zhengping
Z
Zhou
Yunzhong
Y