A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.
Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.
Garber
Kathleen C A
KC
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
Wangkanont
Kittikhun
K
Carlson
Erin E
EE
Kiessling
Laura L
LL
D001665:Binding Sites; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015658:HIV Infections / Q000635:transmission; D006801:Humans; D037181:Lectins, C-Type / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012765:Shikimic Acid / Q000737:chemistry; D054852:Small Molecule Libraries / Q000737:chemistry*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D012765:Shikimic Acid; D054852:Small Molecule Libraries; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin