Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing.
A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Phi(Delta) = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.
Ke
Hanzhong
H
Faculty of Material Science & Chemistry Engineering, China University of Geosciences, Wuhan, Hubei 430074, P. R. China.
Wang
Hongda
H
Wong
Wai-Kwok
WK
Mak
Nai-Ki
NK
Kwong
Daniel W J
DW
Wong
Ka-Leung
KL
Tam
Hoi-Lam
HL
D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D007259:Infrared Rays; D008928:Mitochondria / Q000187:drug effects*; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry / Q000633:toxicity; D012428:Ruthenium / Q000737:chemistry*; D026082:Singlet Oxygen / Q000378:metabolism / Q000633:toxicity; D014466:Ultraviolet Rays
D056831:Coordination Complexes; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D012428:Ruthenium