Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation.
Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes.
Yu
Ye-Ping
YP
The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Lei
Peng
P
Hu
Jia
J
Wu
Wei-Hui
WH
Zhao
Yu-Fen
YF
Li
Yan-Mei
YM
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D058228:Islet Amyloid Polypeptide / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D058228:Islet Amyloid Polypeptide; D017382:Reactive Oxygen Species; D003300:Copper