[Apoptosis induced by bleomycin: influence of cellular models].
Bleomycins are a family of glycopeptides isolated from streptomyces verticillus and exhibiting antibiotic properties. They are commonly included in chemotherapy regimens used to treat patients with Hodgkin's or non Hodgkin's malignant lymphoma, squamous-cell carcinoma or germ-cell tumor. The chemical structure and action mode of bleomycin have been extensively studied, in contrast, the molecular mechanisms of the cytotoxic effects of bleomycin, in vivo, remain poorly understood. Recently, the apoptotics signaling pathway induce by bleomycin was the object of study, of many groups. In this sense, some studies suggested that bleomycin induce in some cells different apoptotic pathway in dose and time depending manner. The sensibility or the resistance to apoptosis induced by bleomycin may explain the sensibility or the resistance of tumor cells to bleomycin. The aim of this review was to describe the machinery of apoptosis induced by bleomycin in tumor cells.
Brahim-Loghmari
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Laboratoire de biochimie, UR-09/09, Faculté de Médecine de Monastir 5019 Monastir, Tunisie.
Kenani
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D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001761:Bleomycin / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D020169:Caspases / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000502:physiology; D053200:Fas-Associated Death Domain Protein / Q000187:drug effects / Q000502:physiology; D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D020929:Mitogen-Activated Protein Kinase Kinases / Q000187:drug effects / Q000502:physiology; D008956:Models, Chemical; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D000903:Antibiotics, Antineoplastic; D053200:Fas-Associated Death Domain Protein; D005609:Free Radicals; D001761:Bleomycin; D020929:Mitogen-Activated Protein Kinase Kinases; D020169:Caspases