title: Nevus simplex: a reconsideration of nomenclature, sites of involvement, and disease associations.
abstract: BACKGROUND
  Nevus simplex (NS) is a common birthmark on the forehead, glabella, upper eyelids, and nape. More widespread involvement can be confused with port-wine stains (nevus flammeus) and other vascular birthmarks.
  
  
  OBJECTIVE
  To further categorize the anatomic locations in infants with extensive NS and evaluate for any possible disease associations.
  
  
  METHODS
  We conducted a retrospective review of patients with extensive NS seen at two tertiary care centers.
  
  
  RESULTS
  Twenty-seven patients with extensive NS were identified. All had at least one typical site of involvement: glabella (77.8%), nape (59.3%), and eyelids (55.6%). Additional sites were the scalp, including the vertex, occiput, parietal (66.7%); nose (66.7%); lip (59.2%); lumbosacral skin (55.6%); and upper and mid back (14.8 %).
  
  
  CONCLUSIONS
  Retrospective nature of the study and relatively small sample size.
  
  
  CONCLUSIONS
  We propose the term "nevus simplex complex" for NS with more widespread involvement beyond the typical sites. Consistent use of the term "nevus simplex" will aid in correct diagnosis and appropriate management of these birthmarks.
authors: Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors: Anna M
authors: AM
authors: Juern
authors: Zoey R
authors: ZR
authors: Glick
authors: Beth A
authors: BA
authors: Drolet
authors: Ilona J
authors: IJ
authors: Frieden
mesh_terms: D001415:Back; D001506:Beckwith-Wiedemann Syndrome / Q000453:epidemiology / Q000473:pathology; D002675:Child, Preschool; D005145:Face / Q000473:pathology; D005260:Female; D018324:Hemangioma, Capillary / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009506:Nevus / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D012535:Scalp / Q000473:pathology; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology*; D009626:Terminology as Topic