title: The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues.
abstract: We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats' paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE(2) in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE(2). Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions.
authors: Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. zoobeadi@yahoo.com
authors: Mustafa
authors: M
authors: Kassim
authors: Mouna
authors: M
authors: Achoui
authors: Marzida
authors: M
authors: Mansor
authors: Kamaruddin Mohd
authors: KM
authors: Yusoff
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000037:antagonists & inhibitors*; D006722:Honey / Q000032:analysis*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D008296:Malaysia; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009569:Nitric Oxide; D015232:Dinoprostone