Imaging of brain tumors: perfusion/permeability.
The use of biomarkers of microvascular structure and function from perfusion and permeability imaging is now well established in neuro-oncological research. There remain significant challenges to be overcome before these techniques and related biomarkers can find general clinical acceptance. Core to this is the standardization of acquisition and processing protocols for robust use across multiple clinical sites. The potential clinical benefits of these approaches are already becoming clear, particularly in the setting of novel antiangiogenic therapies. With an increasing body of evidence in the scientific literature, and with a steadily falling barrier to entry, the coming decade should see rapid developments in imaging biomarkers, and facilitate their transition into routine clinical practice.
Thompson
Gerard
G
School of Cancer and Imaging Sciences, Wolfson Molecular Imaging Centre, The University of Manchester, 27 Palatine Road, Manchester, England M20 3LJ, UK. gerard.thompson@manchester.ac.uk
Mills
Samantha Jane
SJ
Stivaros
Stavros Michael
SM
Jackson
Alan
A
D014408:Biomarkers, Tumor; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D002199:Capillary Permeability; D003287:Contrast Media; D003937:Diagnosis, Differential; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D009389:Neovascularization, Pathologic; D014057:Tomography, X-Ray Computed / Q000379:methods*
D014408:Biomarkers, Tumor; D003287:Contrast Media