title: Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies.
abstract: Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle. Common clinical manifestations include muscle wasting, anemia, reduced caloric intake, and altered immune function, which contribute to increased disability, fatigue, diminished quality of life, and reduced survival. The prevalence of cachexia and the impact of this disorder on the patient and family underscore the need for effective management strategies. Dietary supplementation and appetite stimulation alone are inadequate to reverse the underlying metabolic abnormalities of cancer cachexia and have limited long-term impact on patient quality of life and survival. Therapies that can increase muscle mass and physical performance may be a promising option; however, there are currently no drugs approved for the prevention or treatment of cancer cachexia. Several agents are in clinical development, including anabolic agents, such as selective androgen receptor modulators and drugs targeting inflammatory cytokines that promote skeletal muscle catabolism.
authors: GTx, Inc., Memphis, Tennessee 38103-2802, USA. sdodson@gtxinc.com
authors: Shontelle
authors: S
authors: Dodson
authors: Vickie E
authors: VE
authors: Baracos
authors: Aminah
authors: A
authors: Jatoi
authors: William J
authors: WJ
authors: Evans
authors: David
authors: D
authors: Cella
authors: James T
authors: JT
authors: Dalton
authors: Mitchell S
authors: MS
authors: Steiner
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use; D002100:Cachexia / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009133:Muscular Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D009369:Neoplasms / Q000150:complications* / Q000628:therapy*; D011788:Quality of Life / Q000523:psychology
chemical_list: D045930:Anabolic Agents; D016207:Cytokines