MicroRNA and aging: a novel modulator in regulating the aging network.
miRNAs are a group of noncoding small RNA that are capable of modulating the expression of hundreds of genes via a near-perfect or partial complementary to target mRNA. The ability to regulate multiple targets simultaneously makes miRNA a crucial regulator in many physiological conditions, especially in the aging network and process. The tremendous capability of miRNA supports its ability in regulating ageing, which is a complex process involving multiple interconnected signaling pathways. Even though the relationship between miRNA and ageing is not fully understood, studies have provided evidence showing that miRNAs participate in regulating cell cycle progression, proliferation, stemness gene expression, and stress-induced responses. Molecular studies of ageing and miRNAs would provide a more comprehensive understanding of the mechanisms of ageing and, subsequently, help to ameliorate this universal process compromising our quality of life. In this review article, we focus our attention on miRNA targets in conserved pathways involved in organism aging and aging networks, as well as cellular senescence.
Chen
Li-Hsin
LH
Department of Medical Research and Education, Taipei Veterans General Hospital, 201 Sec 2, Shih-Pai Road, Taipei 112, Taiwan.
Chiou
Guang-Yuh
GY
Chen
Yi-Wei
YW
Li
Hsin-Yang
HY
Chiou
Shih-Hwa
SH
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
D035683:MicroRNAs