title: Sodium iodate selectively injuries the posterior pole of the retina in a dose-dependent manner: morphological and electrophysiological study.
abstract: Sequential morphological and functional features of retinal damage in mice exposed to different doses (40 vs. 20 mg/kg) of sodium iodate (NaIO(3)) were analyzed. Retinal morphology, apoptosis (TUNEL assay), and function (electroretinography; ERG) were examined at several time points after NaIO(3) administration. The higher dose of NaIO(3) caused progressive degeneration of the whole retinal area and total suppression of scotopic and photopic ERG. In contrast, the lower dose induced much less severe degeneration in peripheral part of retina along with a moderate decline of b- and a-wave amplitudes in ERG, corroborating the presence of regions within retina that retain their function. The peak of photoreceptor apoptosis was found on the 3rd day, but the lower dose induced more intense reaction within the central retina than in its peripheral region. In conclusion, these results indicate that peripheral area of the retina reveals better resistance to NaIO(3) injury than its central part.
authors: Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland. annam@sci.pam.szczecin.pl
authors: Anna
authors: A
authors: Machalińska
authors: Wojciech
authors: W
authors: Lubiński
authors: Patrycja
authors: P
authors: Kłos
authors: Miłosz
authors: M
authors: Kawa
authors: Bartłomiej
authors: B
authors: Baumert
authors: Krzysztof
authors: K
authors: Penkala
authors: Ryszard
authors: R
authors: Grzegrzółka
authors: Danuta
authors: D
authors: Karczewicz
authors: Barbara
authors: B
authors: Wiszniewska
authors: Bogusław
authors: B
authors: Machaliński
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004596:Electroretinography; D007452:Iodates / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010786:Photoreceptor Cells / Q000187:drug effects* / Q000502:physiology; D010857:Pigment Epithelium of Eye / Q000187:drug effects*; D012160:Retina / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D012162:Retinal Degeneration / Q000139:chemically induced*; D013047:Specific Pathogen-Free Organisms
chemical_list: D007452:Iodates; C032285:sodium iodate