X-linked inhibitor of apoptosis protein as a therapeutic target in metastatic melanoma.
Melanoma is the most dangerous type of skin cancer, with notorious resistance to current chemotherapy and immunotherapy. In this issue, Hiscutt et al. report on the prognostic significance of X-linked inhibitor of apoptosis protein (XIAP) in melanoma. The finding that XIAP inhibition significantly increases endoplasmic reticulum stress-mediated apoptosis in melanoma cells suggests that XIAP is a potential therapeutic target for melanoma therapy.
Tian
Fang
F
Cutaneous Biology Research Center, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02129, USA.
Lee
Sam W
SW
D000970:Antineoplastic Agents / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human