title: [Use of the induced membrane technique for the treatment of bone defects in the hand or wrist, in emergency].
abstract: A prospective study is reported concerning 11 cases of bone defect of the hand and wrist treated by the induced membrane technique. Ten men and one woman with an average age of 49 yrs (17-72) sustained a high-energy trauma with severe mutilation of digit and hand but with intact pulp. Eight cases of open finger fractures with composite loss of substance and three cases of bone and joint infection (thumb, wrist, fifth finger) were included. All cases were treated by the induced membrane technique which consists in stable fixation, flap if necessary, and in filling the bone defect by a cement methyl methacrylate polymere (PMMA) spacer. A secondary procedure at two months is needed where the cement is removed and the void is filled by cancellous bone. The key point of this induced membrane technique is to respect the foreign body membrane which formed around the cement spacer creating a biologic chamber. Bone union was evaluated prospectively by X-ray and CT scan by a surgeon not involved in the treatment. Failure was defined as non-union at one year, or uncontrolled sepsis at one month. Two cases failed to achieve bone union. No septic complications occurred and all septic cases were controlled. In nine cases, bone union was achieved within four months (three to 12). Evidence of osteoid formation was determined by a bone biopsy in one case. Masquelet first reported 35 cases of large tibial non-union defects treated by the induced membrane technique. The cement spacer promotes foreign body membrane induction constituting a biological chamber. Works on animal models reported by Pellissier and Viateau demonstrated membrane properties: secretion of growths factors (VEGF, TGF beta1, BMP2) and osteoinductive cellular activity. The induced membrane seems to mimic a neoperiosteum. This technique is useful in emergency or septic conditions where bone defects cannot be treated by shortening. It avoids microsurgery and is limited by availability of cancellous bone.
authors: Service de chirurgie orthopédique, traumatologique, de chirurgie plastique et reconstructrice, et assistance main, EA 4268 innovation, imagerie, ingénierie et intervention en santé I4S-IFR 133 Inserm, CHU Jean-Minjoz, Besançon, France. brice.flamans@free.fr
authors: B
authors: B
authors: Flamans
authors: J
authors: J
authors: Pauchot
authors: H
authors: H
authors: Petite
authors: N
authors: N
authors: Blanchet
authors: S
authors: S
authors: Rochet
authors: P
authors: P
authors: Garbuio
authors: Y
authors: Y
authors: Tropet
authors: L
authors: L
authors: Obert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D004630:Emergencies; D005260:Female; D005597:Fractures, Open / Q000000981:diagnostic imaging / Q000601:surgery*; D006230:Hand Injuries / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D011446:Prospective Studies; D011859:Radiography; D013524:Surgical Flaps; D016896:Treatment Outcome; D014954:Wrist Injuries / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D001843:Bone Cements; D008567:Membranes, Artificial; D019904:Polymethyl Methacrylate