title: Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles.
abstract: OBJECTIVE
  To evaluate the efficacy and tolerance of a novel line treatment for periocular and perioral wrinkles. The line treatment was formulated with multiple growth factors, antioxidants, and a collagen-building peptide-ingredients that have been shown to increase collagen levels and provide long-term aesthetic benefits. To help provide immediate smoothing effects, hyaluronic acid filling spheres and a muscle contraction-inhibiting peptide were also included in the formulation.
  
  
  METHODS
  Three-month, single-center, open-label, clinical study with clinical assessments at Baseline, Minutes (within 15 minutes of initial application), Month 1, and Month 3.
  
  
  METHODS
  Subjects treated periocular and perioral wrinkles twice daily for three months with the line treatment.
  
  
  METHODS
  Thirty-seven females, 33 to 45 years of age, with mild-to-moderate, fine and coarse periocular and perioral wrinkles, were enrolled in the study.
  
  
  METHODS
  Investigator assessments of fine and coarse periocular and perioral wrinkles, digital photography, and tolerance assessments were conducted at all visits. Subject self-assessment questionnaires were conducted within 15 minutes of initial application and at Month 3.
  
  
  RESULTS
  Investigator assessments of both periocular and perioral wrinkles showed statistically significant improvements over Baseline within minutes of initial application; these positive findings continued to improve through Months 1 and 3 (all P</=0.0003). No treatment-related adverse events were reported.
  
  
  CONCLUSIONS
  The results from this study demonstrate that this uniquely formulated line treatment was well tolerated and provided both immediate and long-term improvements in the appearance of fine and coarse wrinkles.
authors: Nathan S
authors: NS
authors: Trookman
authors: Ronald L
authors: RL
authors: Rizer
authors: Rosanne
authors: R
authors: Ford
authors: Elizabeth
authors: E
authors: Ho
authors: Vincent
authors: V
authors: Gotz