[Lipid peroxidation and antioxidant protection in patients with different variants of gastro-esophageal reflux disease].
AIM. To study features of lipids peroxide oxidation and function of antioxidant protection in patients with various variants of gastro-esophageal reflux disease (GERD).


METHODS
120 patients with GERD and 20 healthy persons were examinated. Diene conjugates, ketodienes, connected trienes, concentration of intermediants of peroxide oxidation, catalase activity and general antioxidizing activity index were investigated in blood serum and esophageal biopsy specimens by biochemical methods.


RESULTS
The level of peroxide oxidation products in esophageal biopsy specimens in esophagitis and complicated GERD was 1.8-4.5 times higher then in control group. The level of catalase activity and general antioxidizing activity was 2-5 times lower in patients with the pathology in comparison to healthy persons.


CONCLUSIONS
Patients with GERD had activation of lipids peroxide oxidation accompanied by deficiency of antioxidants in esophageal mucosa and blood serum proportionally to esophagus damage degree.
Solodenova
M E
ME
Tsukanov
V V
VV
Onuchina
E V
EV
Butorin
N N
NN
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood / Q000378:metabolism; D004941:Esophagitis / Q000097:blood / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D004945:Esophagoscopy; D004947:Esophagus / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000097:blood / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D008875:Middle Aged
D000975:Antioxidants; D008054:Lipid Peroxides; D002374:Catalase