Prevalence and stability of antibodies to 37 human papillomavirus types--a population-based longitudinal study.
Information about serostability of cutaneous HPV types over time is very limited. We investigated seroprevalence and serostability of 37 different HPV types over 4½ years in an Australian population-based study. Sera and data were analyzed for 390 people who had never been diagnosed with SCC and had blood collected in 1992, 1993 and 1996. Eighty-six percent of participants were seropositive to at least one of the 37 HPV types at baseline. HPV-4 was the type with the highest seroprevalence (41%), followed by HPV-38 and HPV-8 (both 33%). Over 90% of people retained their baseline serostatus during the 4½ year follow-up. Highest serostability was observed for HPV-88 (99.7% stayed seropositive or seronegative), while HPV-65 was least stable with 17% altering their serostatus during follow-up. Seroprevalence to cutaneous HPV types are relatively stable over time, and a single measure can be used as a reasonable marker of long-term antibody status.
Antonsson
Annika
A
Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, The University of Queensland, Brisbane, Queensland, Australia.
Green
Adele C
AC
Mallitt
Kylie-ann
KA
O'Rourke
Peter K
PK
Pandeya
Nirmala
N
Pawlita
Michael
M
Waterboer
Tim
T
Neale
Rachel E
RE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D001315:Australia / Q000453:epidemiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000276:immunology*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology*; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral