Antimicrobial and DNA-cleavage studies of 22-membered N4 tetraaza macrocyclic triazoles: template synthesis and physicochemical characterization.
A novel series of 22-membered macrocyclic complexes of the type [MLCl(2)] (M=Co(2+), Ni(2+) and Cu(2+)) have been synthesized with newly derived biologically active ligands (L(1)-L(IV)). These ligands were synthesized by the condensation of ortho-phthalaldehyde and bis-(4-amino-5-mercapto-1, 2, 4-triazole-3-yl)alkanes. The mode of bonding and overall geometry of the complexes have been inferred through IR, EPR, electronic spectral studies, conductivity, magnetic, thermal, and electrochemical studies. All these complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by the minimal inhibitory concentration (MIC) method. The DNA cleavage study was done by agarose gel electrophoresis technique.
Patil
Sangamesh A
SA
P G Department of Chemistry, Karnatak University, Dharwad, Karnataka, India. patil1956@rediffmail.com
Kamble
Udaykumar V
UV
Badami
Prema S
PS
D000447:Aldehydes / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D003035:Cobalt / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004563:Electrochemistry; D004587:Electrophoresis, Agar Gel; D005658:Fungi / Q000187:drug effects; D008280:Magnetics; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases / Q000737:chemistry; D013057:Spectrum Analysis; D013818:Thermogravimetry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000447:Aldehydes; D000890:Anti-Infective Agents; D012545:Schiff Bases; D014230:Triazoles; D003035:Cobalt; D004247:DNA