title: In vitro osteoblast-like cell proliferation on nano-hydroxyapatite coatings with different morphologies on a titanium-niobium shape memory alloy.
abstract: The morphology of nanomaterials significantly affects their physical, chemical, and biological properties. In the present study, nano-hydroxyapatite coatings with different morphologies were produced on the surface of a titanium-niobium shape memory alloy via a hydrothermal process. The effect of the nano-hydroxyapatite coatings on the in vitro proliferation of SaOS-2 osteoblast-like cells was investigated. Factors including crystallinity, surface micro-roughness, and surface energy of the nano-hydroxyapatite coatings were discussed. Results show that in vitro proliferation of the osteoblast-like cells was significantly enhanced on the nano-hydroxyapatite-coated titanium-niobium alloy compared to the titanium-niobium alloy without coating. The cell numbers on the nano-hydroxyapatite-coated titanium-niobium alloy changed consistently with the surface energy of the hydroxyapatite coatings. This study suggests that surface energy as a characteristic parameter influencing the in vitro proliferation of osteoblast-like cells was predominant over the crystallinity and surface micro-roughness of the nano-hydroxyapatite coatings.
authors: Institute for Technology Research and Innovation, Deakin University, Waurn Ponds, Victoria 3217, Australia.
authors: Jianyu
authors: J
authors: Xiong
authors: Yuncang
authors: Y
authors: Li
authors: Peter D
authors: PD
authors: Hodgson
authors: Cui'e
authors: C
authors: Wen
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D017886:Durapatite / Q000737:chemistry* / Q000378:metabolism; D019855:Ethylene Glycol / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry*; D009556:Niobium / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D009556:Niobium; D014867:Water; D017886:Durapatite; D014025:Titanium; D019855:Ethylene Glycol