title: ERG changes in albino and pigmented mice after optic nerve transection.
abstract: Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, the STR-implicit time decreased and the p and nSTR waves diminished approximately to 40% or 55%, in albino or pigmented, respectively, with respect to the values recorded from the non-operated contralateral eyes. These changes were maintained up to 12 weeks post-ONT, demonstrating that the ERG-STR is a useful parameter to monitor RGC functionality in adult mice.
authors: Departamento de Oftalmología, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, Spain.
authors: Luis
authors: L
authors: Alarcón-Martínez
authors: Marcelino
authors: M
authors: Avilés-Trigueros
authors: Caridad
authors: C
authors: Galindo-Romero
authors: Javier
authors: J
authors: Valiente-Soriano
authors: Marta
authors: M
authors: Agudo-Barriuso
authors: Pedro de la
authors: Pde L
authors: Villa
authors: Maria P
authors: MP
authors: Villegas-Pérez
authors: Manuel
authors: M
authors: Vidal-Sanz
mesh_terms: D000417:Albinism / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D004596:Electroretinography; D051379:Mice; D020221:Optic Nerve Injuries / Q000503:physiopathology*; D010858:Pigmentation / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology*; D012684:Sensory Thresholds; D013997:Time Factors