Effectiveness of misoprostol for office hysteroscopy without anesthesia in infertile patients.
OBJECTIVE
To evaluate and compare the effectiveness of oral and vaginal misoprostol versus placebo to facilitate office hysteroscopy without anesthesia during infertile diagnostic evaluation.


METHODS
Randomized, prospective trial.


METHODS
Patients scheduled for diagnostic office hysteroscopy at a university hospital.


METHODS
Seventy-five infertile patients scheduled for diagnostic office hysteroscopy.


METHODS
Patients were divided into three groups: group A received oral misoprostol 600 μg; group B, vaginal misoprostol 400 μg; and group C, oral placebo.


METHODS
Pain, evaluated by visual analogue scale, and surgical time were recorded and compared. Statistical analysis was done using Student's t-test.


RESULTS
Pain was low in the vaginal misoprostol group. Mean visual analogue scale in the oral misoprostol group was 6.04 ± 1.5; in the vaginal misoprostol group 2.85 ± 1.2; and in the placebo group 7.50 ± 1.5. Procedural time for office hysteroscopy was shorter in the vaginal misoprostol group (2.7 ± 1.0 minutes) compared with group A (5.5 ± 1.1 minutes) and group C (6.3 ± 3.8 minutes).


CONCLUSIONS
Vaginal misoprostol, 400 μg, administered the day before office hysteroscopy considerably reduces pain and the time needed for hysteroscopy. This simple strategy may facilitate office hysteroscopy during an infertility work-up.
Sordia-Hernández
Luis Humberto
LH
Department of Obstetrics and Gynecology, University Center of Reproductive Medicine, Hospital Universitario Dr Jose E Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico. lsordia@prodigy.net.mx
Rosales-Tristan
Elizabeth
E
Vazquez-Mendez
Juanita
J
Merino
Martha
M
Iglesias
Jose Luis
JL
Garza-Leal
Jose Gerardo
JG
Morales
Arturo
A
D000282:Administration, Intravaginal; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000758:Anesthesia / Q000379:methods; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D007247:Infertility, Female / Q000601:surgery*; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis; D010919:Placebos; D016896:Treatment Outcome; D055815:Young Adult
D010120:Oxytocics; D010919:Placebos; D016595:Misoprostol