Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate.
A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and applicable to a wide variety of four-component reactions.
Sun
Jing
J
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Xia
Er-Yan
EY
Wu
Qun
Q
Yan
Chao-Guo
CG