title: Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients.
abstract: Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients.
authors: Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universität Tübingen, Otfried-Mueller-Straße 10, Tübingen, Germany. konstantinos.stellos@med.uni-tuebingen.de
authors: Konstantinos
authors: K
authors: Stellos
authors: Victoria
authors: V
authors: Panagiota
authors: Andreas
authors: A
authors: Kögel
authors: Thomas
authors: T
authors: Leyhe
authors: Meinrad
authors: M
authors: Gawaz
authors: Christoph
authors: C
authors: Laske
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology*; D018450:Disease Progression; D005434:Flow Cytometry; D006801:Humans; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D011237:Predictive Value of Tests; D013997:Time Factors
chemical_list: D015415:Biomarkers; D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex