Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.
OBJECTIVE
Hypertension often persists after adrenalectomy for primary aldosteronism. Traditional factors associated with postoperative hypertension were evaluated, but whether genetic determinants were involved remains poorly understood. The aim of this study was to investigate the association of DNA polymorphisms within steroid synthesis genes (CYP11B2, CYP11B1) and the postoperative resolution of hypertension in Chinese patients undergoing adrenalectomy for aldosterone-producing adenomas (APA).


METHODS
Ninety-three patients with APA were assessed for postoperative resolution of hypertension. All patients were genotyped for rs1799998 (C-344 T), intron 2 conversion, rs4539 (A2718G) within CYP11B2 and rs6410 (G22 5A), rs6387 (A2803G) within CYP11B1. The associations between CYPB11B2/CYP11B1 polymorphisms and persistent postoperative hypertension were assessed by multivariate analysis.


RESULTS
CYP11B2-CYP11B1 haplotype was associated with persistent postoperative hypertension in Chinese patients undergoing adrenalectomy with APA (P = .006). Specifically, the rs4539 (AA) polymorphism was associated with persistent postoperative hypertension (P = .002). Multivariate logistic regression revealed the common haplotypes H1 (AGACT), H2 (AGAWT), and H3 (AGAWC) were associated with the persistent postoperative hypertension (P = .01, 0.03, 0.005 after Bonferroni correction). Additional predictors of persistent postoperative hypertension included duration of hypertension (P <.0005), family history of hypertension (P = .001), and elevated systolic blood pressure (P = .015).


CONCLUSIONS
The rs4539 (AA), H1, H2, and H3 are genetic predictors for postoperative persistence of hypertension for Chinese patients treated by adrenalectomy with APA. DNA polymorphisms at CYP11B2/B1 locus may confer susceptibility to postoperative hypertension of patients with APA.
Wang
Baojun
B
Department of Urology, China PLA General Hospital, Beijing, People's Republic of China.
Zhang
Guoxi
G
Ouyang
Jinzhi
J
Deng
Xiyuan
X
Shi
Taoping
T
Ma
Xin
X
Li
Hongzhao
H
Ju
Zhenghua
Z
Wang
Chao
C
Wu
Zhun
Z
Liu
Shuanglin
S
Zhang
Xu
X
D000306:Adrenal Cortex Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000601:surgery*; D000315:Adrenalectomy; D018246:Adrenocortical Adenoma / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000601:surgery*; D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006929:Hyperaldosteronism / Q000453:epidemiology / Q000209:etiology / Q000235:genetics* / Q000601:surgery; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D007438:Introns / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D013252:Steroid 11-beta-Hydroxylase / Q000235:genetics*
D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2; D013252:Steroid 11-beta-Hydroxylase