Antiretroviral therapy as HIV prevention: status and prospects.
As antiretroviral treatment of HIV infection has become increasingly accessible, attention has focused on whether these drugs can used for prevention because of increased tolerability of newer medications, decreased cost, and the limitations of other approaches. We review the status of antiretroviral HIV prevention, including chemoprophylaxis, as well as the effects of treatment of infected individuals on prevention. It is possible that the life-saving agents that have transformed the natural history of AIDS can be a critical component of HIV prevention efforts, but their ultimate role in affecting HIV transmission dynamics remains to be defined.
Mayer
Kenneth H
KH
Alpert Medical School, Brown University, Providence, RI, USA. Kenneth_Mayer@brown.edu
Venkatesh
Kartik K
KK
D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data*; D018890:Chemoprevention; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D014943:Global Health; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control*; D015438:Health Behavior; D006291:Health Policy; D006801:Humans; D008297:Male; D056990:Post-Exposure Prophylaxis; D011322:Primary Prevention
D044966:Anti-Retroviral Agents