Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients.
OBJECTIVE
To evaluate the relative effectiveness of hysterectomy, endometrial destruction (both "first generation" hysteroscopic and "second generation" non-hysteroscopic techniques), and the levonorgestrel releasing intrauterine system (Mirena) in the treatment of heavy menstrual bleeding.


METHODS
Meta-analysis of data from individual patients, with direct and indirect comparisons made on the primary outcome measure of patients' dissatisfaction.


METHODS
Data were sought from the 30 randomised controlled trials identified after a comprehensive search of the Cochrane Library, Medline, Embase, and CINAHL databases, reference lists, and contact with experts. Raw data were available from 2814 women randomised into 17 trials (seven trials including 1359 women for first v second generation endometrial destruction; six trials including 1042 women for hysterectomy v first generation endometrial destruction; one trial including 236 women for hysterectomy v Mirena; three trials including 177 women for second generation endometrial destruction v Mirena). Eligibility criteria for selecting studies Randomised controlled trials comparing hysterectomy, first and second generation endometrial destruction, and Mirena for women with heavy menstrual bleeding unresponsive to other medical treatment.


RESULTS
At around 12 months, more women were dissatisfied with outcome with first generation hysteroscopic techniques than with hysterectomy (13% v 5%; odds ratio 2.46, 95% confidence interval 1.54 to 3.9, P<0.001), but hospital stay (weighted mean difference 3.0 days, 2.9 to 3.1 days, P<0.001) and time to resumption of normal activities (5.2 days, 4.7 to 5.7 days, P<0.001) were longer for hysterectomy. Unsatisfactory outcomes were comparable with first and second generation techniques (odds ratio 1.2, 0.9 to 1.6, P=0.2), although second generation techniques were quicker (weighted mean difference 14.5 minutes, 13.7 to 15.3 minutes, P<0.001) and women recovered sooner (0.48 days, 0.20 to 0.75 days, P<0.001), with fewer procedural complications. Indirect comparison suggested more unsatisfactory outcomes with second generation techniques than with hysterectomy (11% v 5%; odds ratio 2.3, 1.3 to 4.2, P=0.006). Similar estimates were seen when Mirena was indirectly compared with hysterectomy (17% v 5%; odds ratio 2.2, 0.9 to 5.3, P=0.07), although this comparison lacked power because of the limited amount of data available for analysis.


CONCLUSIONS
More women are dissatisfied after endometrial destruction than after hysterectomy. Dissatisfaction rates are low after all treatments, and hysterectomy is associated with increased length of stay in hospital and a longer recovery period. Definitive evidence on effectiveness of Mirena compared with more invasive procedures is lacking.
Middleton
L J
LJ
Birmingham Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT. l.j.middleton@bham.ac.uk
Champaneria
R
R
Daniels
J P
JP
Bhattacharya
S
S
Cooper
K G
KG
Hilken
N H
NH
O'Donovan
P
P
Gannon
M
M
Gray
R
R
Khan
K S
KS
Abbott
J
J
Barrington
J
J
Bhattacharya
S
S
Bongers
M Y
MY
Brun
J-L
JL
Busfield
R
R
Sowter
M
M
Clark
T J
TJ
Cooper
J
J
Cooper
K G
KG
Corson
S L
SL
Dickersin
K
K
Dwyer
N
N
Gannon
M
M
Hawe
J
J
Hurskainen
R
R
Meyer
W R
WR
O'Connor
H
H
Pinion
S
S
Sambrook
A M
AM
Tam
W H
WH
van Zon-Rabelink
I A A
IA
Zupi
E
E
D000328:Adult; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D004717:Endometrium / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007436:Intrauterine Devices, Medicated; D007902:Length of Stay; D016912:Levonorgestrel / Q000008:administration & dosage*; D008595:Menorrhagia / Q000628:therapy*; D017060:Patient Satisfaction; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D016896:Treatment Outcome
D003271:Contraceptive Agents, Female; D016912:Levonorgestrel