[Expressions of Frat and beta-catenin in lung cancer and their clinicopathological correlations.].
BACKGROUND
Frat proteins are positive regulator of Wnt-signal transduction.By binding to GSK3,Frat prevents the phosphorylation and concomitant degradation of beta-catenin and allows the activation of downstream targetgenes by beta-catenin/TCF complexes. The aim of this study is to investigate the protein expression of Frat and beta-catenin and their clinicopathological correlations in lung cancer.


METHODS
By means of tissue chip technique and immunohistochemical method, 52 cases of lung carcinoma were examed to detect the expression of Frat and beta-catenin.


RESULTS
The positive expression rate of Frat was 75% . The positive expression rate of Frat in well,moderately and poorly differentiated NSCLCs were 41.67%(5/12), 83.33%(15/18) and 88.24%(15/17). There was a significant difference in Frat expression among well,moderately and poorly differentiated NSCLCs (Chi-Square=9.229, P=0.01). The abnormal cell expression rate of beta-catenin was 71.15%. The abnormal cell expression rate of beta-catenin in well,moderately and poorly differentiated NSCLCs were 41.67%(5/12), 61.11%(11/18) and 100%(17/17). There was a significant difference (Chi-Square=12.601, P=0.002).


CONCLUSIONS
The abnormal cell expression of beta-catenin is associated with pooly differentiated NSCLCs. The expression of Frat is positively correlated with the degree of tumor differentiation and the abnormal cell expression of beta-catenin.
Luan
Lan
L
Department of Pathology, College of Basic Medical Science,China Medical University,Shenyang,Liaoning 110001,China.
Zhang
Yong
Y
Guo
Ning
N
Wang
Enhua
E