A new functional role of HIV-1 integrase during uncoating of the viral core.
An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.
Briones
Marisa S
MS
Department of Molecular and Medical Pharmacology, Molecular Biology Institute, 650 Charles E. Young Drive, Los Angeles, CA 90095, USA.
Chow
Samson A
SA
D000090103:Antiviral Restriction Factors; D036022:Capsid Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D021984:Cyclophilin A / Q000378:metabolism*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D019427:HIV Integrase / Q000378:metabolism*; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D014758:Viral Core Proteins / Q000378:metabolism; D016662:Virus Integration; D014779:Virus Replication
D000090103:Antiviral Restriction Factors; D036022:Capsid Proteins; D002352:Carrier Proteins; D000070584:Tripartite Motif Proteins; D014758:Viral Core Proteins; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases; D019427:HIV Integrase; D021984:Cyclophilin A