title: Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus.
abstract: Older human immunodeficiency virus-seropositive (HIV+) individuals (greater than age 50 years) are twice as likely to develop HIV dementia compared to younger HIV+ individuals. The objective of this study was to examine the impact of both age and serostatus on longitudinal changes in psychomotor speed/executive functioning performance among HIV+ and HIV− individuals. Four hundred and seventy-seven HIV+ and 799 HIV− individuals from the Multicenter AIDS Cohort Study (MACS) were subdivided into three age groups: (1) <40 years, (2) 40-50 years, and (3) >50 years. Psychomotor speed/executive functioning test performance was measured by the Symbol Digit Modalities Test (SDMT) and the Trail Making (TM) Test Parts A and B. Changes in performance were compared among the three age groups for both HIV+ and HIV− individuals. Among HIV+ individuals, on the TM Test Part B the younger group demonstrated improvement in performance over time (P = .007). The older and middle age groups demonstrated decline in performance over time (P = .041 and .030). The older group had a significantly different trajectory relative to the younger group (P = .046). Among the HIV− individuals, there was no effect of age on longitudinal performance. In conclusion, older HIV+ individuals show greater decline over time than younger HIV+ individuals on the TM Test Part B. Our results suggest that both HIV serostatus and age together may impact longitudinal performance on this test. Mild neurocognitive changes over time among older HIV+ individuals are likely to reflect age associated pathophysiological mechanisms including cerebrovascular risk factors.
authors: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. sacktor@jhmi.edu
authors: Ned
authors: N
authors: Sacktor
authors: Richard L
authors: RL
authors: Skolasky
authors: Christopher
authors: C
authors: Cox
authors: Ola
authors: O
authors: Selnes
authors: James T
authors: JT
authors: Becker
authors: Bruce
authors: B
authors: Cohen
authors: Eileen
authors: E
authors: Martin
authors: Eric N
authors: EN
authors: Miller
mesh_terms: D015526:AIDS Dementia Complex / Q000150:complications / Q000503:physiopathology*; D000328:Adult; D000367:Age Factors; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011596:Psychomotor Disorders / Q000821:virology*; D012307:Risk Factors; D013647:Task Performance and Analysis; D014481:United States
chemical_list: D019380:Anti-HIV Agents