title: Resistance to activated protein C and ischemic arterial disease in a young man.
abstract: The assessment of activated protein C resistance (APCR) caused by mutations in factor V (factor V Leiden) is an important risk factor for venous thromboembolism, of which role as the originator of arterial obstructions in situ is still a controversial subject. The clinical case of a young patient with history of coronariopathy, multiple cerebrovascular lesions and peripheral artery disease is reported. The diagnostic investigation showed APCR as the possible etiology.
authors: Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors: Igor Alexandre Côrtes de
authors: IA
authors: Menezes
authors: Rafael Fernandes
authors: RF
authors: Romani
authors: Yuki Schneider
authors: YS
authors: Aoki
authors: João Caetano
authors: JC
authors: Abdo
authors: Mauricio
authors: M
authors: Carvalho
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications*; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000209:etiology; D002545:Brain Ischemia / Q000209:etiology*; D003327:Coronary Disease / Q000209:etiology*; D005165:Factor V / Q000235:genetics; D006801:Humans; D008297:Male; D058729:Peripheral Arterial Disease / Q000209:etiology*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V