[Features of cytokine levels in serum of patients with tick-borne borreliosis with different clinical signs].
OBJECTIVE
To assess levels of several cytokines in blood of patients with tick-borne borreliosis (Lyme disease) with different clinical variants of the disease.


METHODS
Study of complex of proinflammatory cytokines (IFNalpha, IL-1beta, IFNgamma, IL-2, IL-4, IL-8) during course of the disease was performed by solid-phase ELISA using domestic diagnostic kits (Scientific Manufacturing Organization "Proteinovyi Contur", "Cytokine" Ltd., Saint Petersburg). Levels of TNFalpha was determined by ELISA using commercial kits "Boehringer Manheim" (Austria).


RESULTS
Performed comparative clinico-laboratory analysis demonstrated increased levels of LL-2, IL-4, and IL-8 in patients during acute phase of tick-borne borreliosis that could point to host's response on bacterial infection. It should be noted that in patients with arthritis levels of LL-4 and IL-2 remained high during recovery phase that probably determined by possible persistence of Borrelia burgdorferi.


CONCLUSIONS
Further research of cytokines during Lyme borreliosis could have important diagnostic and prognostic value.
Burgasova
O A
OA
Uskov
A N
AN
Grichenko
N E
NE
Tseneva
G Ia
GIa
D001168:Arthritis / Q000097:blood / Q000209:etiology; D025065:Borrelia burgdorferi; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008193:Lyme Disease / Q000097:blood* / Q000150:complications / Q000378:metabolism; D013997:Time Factors
D016207:Cytokines