Malignancies in pediatric solid organ transplant recipients: epidemiology, risk factors, and prophylactic approaches.
OBJECTIVE
To review current opinions about the epidemiology, risk factors, and approaches to prevent malignancies in pediatric transplant recipients.


RESULTS
Recent studies looking at the risk of newer induction agents and viral etiologies are reviewed. The recent introduction of viral immunizations as prophylaxis is also discussed.


CONCLUSIONS
Children remain one of the most vulnerable populations for developing cancer posttransplant. This is because of multiple variables, but especially because of immune naivete and longer periods of immunosuppression. As transplantation gets more complex, with discovery of newer immunosuppressive agents and viral agents, all of these affect the incidence of malignancy in the posttransplant period. A review of the latest literature in this aspect with data from the largest current transplant databases is herein presented.
Paramesh
Anil
A
Tulane Abdominal Transplant Institute, Department of Surgery, Tulane University, New Orleans, Louisiana 70112, USA.
Cannon
Robert
R
Buell
Joseph F
JF
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D016377:Organ Transplantation / Q000009:adverse effects*; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014765:Viral Vaccines; D014777:Virus Diseases / Q000209:etiology / Q000517:prevention & control
D007166:Immunosuppressive Agents; D014765:Viral Vaccines