title: Sequence analysis of meq oncogene among Polish strains of Marek's disease.
abstract: The main goal of the present study was to analyse the nucleotide and amino acid sequence of Meq--the main oncoprotein of Marek's disease virus. The conducted analysis of the nucleotide sequences of MDV has shown a significant similarity between Polish and reference strains of MDV assigned to the vvMDV and vv+MDV pathotypes. Some of the detected nucleotide point mutations were specific only for Polish strains. The sequence analysis has shown a number of single substitutions and two poly-amino acid insertions among strains defined as mild-pathogenic (mMDV) and one attenuated vaccine strain CVI988--Rispens. These results indicate that there is a close relation between changes in nucleotide or amino acid sequence of meq and the virulence of Polish MDV strains.
authors: National Veterinary Research Institute, Department of Poultry Viral Diseases, Partyzantów 57 Avenue, 24-100 Puławy, Poland. grzegorz.wozniakowski@piwet.pulawy.pl
authors: G
authors: G
authors: Woźniakowski
authors: E
authors: E
authors: Samorek-Salamonowicz
authors: W
authors: W
authors: Kozdruń
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D008381:Herpesvirus 2, Gallid / Q000145:classification / Q000235:genetics*; D008380:Marek Disease / Q000453:epidemiology / Q000821:virology*; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D011044:Poland / Q000453:epidemiology; D011200:Poultry
chemical_list: C100369:Eco-Q protein, Gallid herpesvirus 2; D009856:Oncogene Proteins, Viral