Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.
Alpha-synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of alpha-synuclein.
Wang
Chengshan
C
California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA.
Shah
Nilam
N
Thakur
Garima
G
Zhou
Feimeng
F
Leblanc
Roger M
RM
D000388:Air; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry*; D051844:alpha-Synuclein / Q000737:chemistry*
D051844:alpha-Synuclein; D014867:Water