title: Association with TP53 codon 72 polymorphism and the risk of non-Hodgkin lymphoma.
abstract: Polymorphism of TP53 Arg72Pro is associated with many different cancers[1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72CC genotype was associated with increased risk of NHL (P 5 0.04) and diffuse large B-cell lymphoma (P 5 0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.
authors: Hee Nam
authors: HN
authors: Kim
authors: Li
authors: L
authors: Yu
authors: Nan Young
authors: NY
authors: Kim
authors: Il-Kwon
authors: IK
authors: Lee
authors: Yeo-Kyeoung
authors: YK
authors: Kim
authors: Deok-Hwan
authors: DH
authors: Yang
authors: Je-Jung
authors: JJ
authors: Lee
authors: Min-Ho
authors: MH
authors: Shin
authors: Kyeong-Soo
authors: KS
authors: Park
authors: Jin-Su
authors: JS
authors: Choi
authors: Hyeoung-Joon
authors: HJ
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003062:Codon / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D055815:Young Adult
chemical_list: D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53