title: Body mass index reflects islet isolation outcome in islet autotransplantation for patients with chronic pancreatitis.
abstract: Total pancreatectomy with autologous islet cell transplantation (TP with AIT) is an effective treatment for chronic pancreatitis patients with severe abdominal pain. Body mass index (BMI) of the pancreatic donor is proven to be a useful predictor for islet isolation and transplantation outcomes in allogenic islet transplantation. However, the association between BMI and islet isolation outcome and/or metabolism after AIT was previously unclear. Twelve patients who received TP with AIT at our hospital were included in this study. All pancreata were preserved with both pancreatic ductal injection and oxygen-charged static two-layer method using ET-Kyoto solution. The cohort was divided into two groups: low BMI group (BMI <23 kg/m(2), n=5) and high BMI group (BMI ≥23, n=7). The high BMI group had a significantly higher islet yield per gram than the low BMI group both in pancreas postdigestion and in final product (postdigestion: 7330 ± 539 vs. 3509 ± 563 IE/g; p<0.001; final product: 6555 ± 585 vs. 3476 ± 546 IE/g; p=0.004). For islet yield in final product per patient body weight, the high BMI group also had significantly higher islet yield than the low BMI group (7997 ± 779 vs. 4175 ± 750 IE/kg, p=0.007). Insulin independence rate in the high BMI group (71%) was also higher than that low BMI group (40%), but it did not reach statistical significance. Pancreata from patients with higher BMI could obtain higher islet yield in the setting of autologous islet cell transplantation for chronic pancreatitis.
authors: Baylor Research Institute Fort Worth Campus, Fort-Worth, TX 76104, USA.
authors: Morihito
authors: M
authors: Takita
authors: Bashoo
authors: B
authors: Naziruddin
authors: Shinichi
authors: S
authors: Matsumoto
authors: Hirofumi
authors: H
authors: Noguchi
authors: Masayuki
authors: M
authors: Shimoda
authors: Daisuke
authors: D
authors: Chujo
authors: Takeshi
authors: T
authors: Itoh
authors: Koji
authors: K
authors: Sugimoto
authors: Yoshiko
authors: Y
authors: Tamura
authors: Greg S
authors: GS
authors: Olsen
authors: Nicholas
authors: N
authors: Onaca
authors: Jeffrey
authors: J
authors: Lamont
authors: Luis F
authors: LF
authors: Lara
authors: Marlon F
authors: MF
authors: Levy
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002469:Cell Separation; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D009929:Organ Size; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010180:Pancreatectomy; D050500:Pancreatitis, Chronic / Q000601:surgery / Q000628:therapy*; D012372:ROC Curve; D015203:Reproducibility of Results; D014182:Transplantation, Autologous; D016896:Treatment Outcome