title: Anti-hypoxia activity and related components of Rhodobryum giganteum par.
abstract: Different extracts of Rhodobryum giganteum Par. were screened with mice model of acute myocardial hypoxia induced by isoproterenol and pituitrin, eight compounds, i.e. p-hydroxycinnamic acid, caffeic acid-4-O-β-d-glucopyranoside, salicin, 7,8-dihydroxy coumarin, menthol, allantoin, palmitic acid, palmitamide were isolated and identified from the active fraction, among which p-hydroxycinnamic acid and 7,8-dihydroxy coumarin were confirmed having protective effects on myocardial hypoxia-reoxygenation injury, suggesting that these two components were major active ingredients of R. giganteum for cardiovascular disease.
authors: General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing 210002, China.
authors: Ying
authors: Y
authors: Cai
authors: Yu
authors: Y
authors: Lu
authors: Ruihua
authors: R
authors: Chen
authors: Qunli
authors: Q
authors: Wei
authors: Xiaohe
authors: X
authors: Lu
mesh_terms: D000818:Animals; D044002:Bryophyta / Q000737:chemistry*; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy*; D007545:Isoproterenol; D008297:Male; D051379:Mice; D015428:Myocardial Reperfusion Injury / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010909:Pituitary Hormones, Posterior; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002934:Cinnamates; D003374:Coumarins; D010909:Pituitary Hormones, Posterior; D010936:Plant Extracts; C029010:cinnamic acid; C030123:coumarin; D007545:Isoproterenol