title: In growing pigs, chlortetracycline induces a reversible green bone discoloration and a persistent increase of bone mineral density dependent of dosing regimen.
abstract: We studied in growing pigs the effects of exposure to dietary chlortetracycline on bone mineral density (BMD) and bone color. Pigs were randomly allocated to a drug-free diet (n=48) or a diet fortified with 800 ppm of chlortetracycline, starting either at 28- or 84-d of age, and for either a 28- or 56-d duration (n=16 pigs/group). The lumbar vertebral discoloration and BMD of randomly chosen pigs were evaluated at 28-d intervals up to 168-d of age. The odds of bone discoloration increased with dosing duration and age at treatment onset, and decreased with the withdrawal time and age at treatment onset interaction (p < or = 0.001). The measured trabecular BMD linearly increased with age and squared treatment duration (p < or = 0.005). Therefore, TC-induced bone discoloration is reversible, and may be prevented with proper dosing regimen design. Moreover, TC induces a persistent increase on BMD that could be detected with quantitative computed tomography.
authors: Groupe de Recherche en Pharmacologie Animale du Québec, Centre de Recherche en Infectiologie Porcine (CRIP), Department of Veterinary Biomedical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, C.P. 5000 Saint-Hyacinthe, Québec, Canada J2S 7C6.
authors: Martin
authors: M
authors: Guillot
authors: Kate
authors: K
authors: Alexander
authors: Candido
authors: C
authors: Pomar
authors: Jérôme R E
authors: JR
authors: Del Castillo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D015519:Bone Density / Q000187:drug effects*; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002751:Chlortetracycline / Q000009:adverse effects* / Q000494:pharmacology; D003116:Color; D004305:Dose-Response Relationship, Drug; D008159:Lumbar Vertebrae / Q000187:drug effects; D008297:Male; D013552:Swine / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D002751:Chlortetracycline