Determination of pKa values of benzimidazole derivatives from mobility obtained by capillary electrophoresis.
Dissociation constants of benzimidazole derivatives have been determined using capillary zone electrophoresis (CZE). Since CZE is a separation method, high purity and known concentration for the samples is not necessary because only mobilities are measured. The precision of pK(a) measurements of seven compounds is useful to observe pK(a) shifts induced by chemical variations. Some of them were compared to potentiometry and spectroscopy experiments. Good correlated pK(a) values are observed between the three analytical techniques.
Lipka
Emmanuelle
E
Laboratoire de Chimie Analytique - EA 4481, Univ. Lille Nord de France, F-59000 Lille, France.
Folly-Klan
Marcia
M
Charton
Julie
J
Vaccher
Marie-Pierre
MP
Bonte
Jean-Paul
JP
Vaccher
Claude
C
D001562:Benzimidazoles / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods; D024202:Electrophoretic Mobility Shift Assay / Q000379:methods*; D006863:Hydrogen-Ion Concentration
D001562:Benzimidazoles; C031000:benzimidazole