N,O-diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents.
Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.
Chowdhury
Nilanjana
N
Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India.
Dutta
Sansa
S
Nishitha
Boda
B
Dasgupta
Swagata
S
Singh
N D Pradeep
ND
D053837:DNA Cleavage / Q000528:radiation effects; D004270:DNA, Circular / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry* / Q000494:pharmacology*; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D014466:Ultraviolet Rays
D004270:DNA, Circular; D006898:Hydroxylamines; D017319:Photosensitizing Agents; C012484:phenylhydroxylamine