Status epilepticus treatment and outcome in children: what might the future hold?
Status epilepticus is a life-threatening emergency that requires urgent treatment. Over the past decade, numerous advances have been made in the management of status epilepticus. Clinical studies have now established the benefit of early, aggressive treatment of status epilepticus with benzodiazepines in both prehospital and hospital settings. Neuroscientific advances are revealing mechanisms of status epilepticus that could translate into targets for treating acute status epilepticus and even reducing epileptogenesis. This article discusses future trends in the diagnosis, neurobiology, and treatment of status epilepticus.
Zawadzki
Lucyna
L
Department of Neurology, Section of Pediatric Neurology, University of Wisconsin, Madison, WI 53705, USA.
Stafstrom
Carl E
CE
D000367:Age Factors; D000927:Anticonvulsants / Q000008:administration & dosage*; D001921:Brain / Q000502:physiology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002648:Child; D016503:Drug Delivery Systems / Q000379:methods; D004358:Drug Therapy / Q000639:trends*; D004359:Drug Therapy, Combination; D015507:Drugs, Investigational / Q000627:therapeutic use; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D013226:Status Epilepticus / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*
D000927:Anticonvulsants; D015507:Drugs, Investigational