title: High prevalence of multidrug-resistant strains of Vibrio cholerae, in a cholera outbreak in Tehran-Iran, during June-September 2008.
abstract: Following the occurrence of suspected cases of Vibrio cholerae in Karaj in 2008, this study was conducted in order to determine whether or not the cases were infected with cholera and, if so, to describe the prevalence of serotypes, route of transmission and the antimicrobial resistance profile. In this cross-sectional study, 6505 rectal swabs were collected from patients with acute gastroenteritis. Serotypes and biotypes of the isolates were determined by standard procedures. The antimicrobial susceptibility of 45 Inaba and 30 non-agglutinating (NAG) strains was determined. From 6505 specimens, 110 (1.69%) were defined as V. cholerae, including 70 (63.3%) V. cholerae O1 serotype Inaba biotype El Tor and 40 (36.4%) NAG Vibrios. The case fatality rate was 0.9%. Inaba strains were 100% resistant to nalidixic acid and amoxicillin, 95.7% resistant to trimethoprim-sulfamethoxazole, 91.3% resistant to furazolidone while the highest frequency of resistance in NAG Vibrios was 77.4% to erythromycin. The lowest resistance rate belonged to ciprofloxacin to which just one NAG strain was resistant. Results suggests an increase in resistance of V. cholerae to several antibiotics. Ciprofloxacin can still be used as first-line treatment of cholera in this region.
authors: Department of Infectious Diseases, Firoozgar Hospital, Iran University of Medical Sciences, Tehran. swt_f@yahoo.com
authors: Mitra
authors: M
authors: Ranjbar
authors: Elham
authors: E
authors: Rahmani
authors: Abas
authors: A
authors: Nooriamiri
authors: Hossein
authors: H
authors: Gholami
authors: Ali
authors: A
authors: Golmohamadi
authors: Hojatollah
authors: H
authors: Barati
authors: Dina
authors: D
authors: Rajabifar
authors: Somayeh
authors: S
authors: Barati
authors: Mahdiyeh Shafiee
authors: MS
authors: Sabet
authors: Alaleh
authors: A
authors: Zamiri
authors: Sama
authors: S
authors: Haghighi
authors: Pariva
authors: P
authors: Taifehashemi
authors: Marziyeh
authors: M
authors: Nojomi
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002771:Cholera / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D014734:Vibrio cholerae / Q000187:drug effects / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents