title: Up a hydrophobic creek with a short paddle.
abstract: The mechanism by which voltage-dependent ion channels sense membrane potentials has been the most intensively studied and debated topic in modern ion channel research. In this issue, Xu et al. (2010) provide new insights into the minimal topological and physicochemical features required for voltage sensing.
authors: Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.
authors: Raymond E
authors: RE
authors: Hulse
authors: Qufei
authors: Q
authors: Li
authors: Eduardo
authors: E
authors: Perozo