title: Synthetic use of the primary kinetic isotope effect in hydrogen atom transfer: generation of α-aminoalkyl radicals.
abstract: The extent to which deuterium can act as a protecting group to prevent unwanted 1,5-hydrogen atom transfer to aryl and vinyl radical intermediates was examined in the context of the generation of α-aminoalkyl radicals in a pyrrolidine ring. Intra- and intermolecular radical trapping following hydrogen atom transfer provides an illustration of the use of the primary kinetic isotope effect in directing the outcome of synthetic C-C bond-forming processes.
authors: School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, UKEX4 4QD. m.e.wood@exeter.ac.uk
authors: Mark E
authors: ME
authors: Wood
authors: Sabine
authors: S
authors: Bissiriou
authors: Christopher
authors: C
authors: Lowe
authors: Andrew M
authors: AM
authors: Norrish
authors: Katell
authors: K
authors: Sénéchal
authors: Kim M
authors: KM
authors: Windeatt
authors: Simon J
authors: SJ
authors: Coles
authors: Michael B
authors: MB
authors: Hursthouse
mesh_terms: D003903:Deuterium / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D006860:Hydrogen Bonding; D007700:Kinetics; D008958:Models, Molecular
chemical_list: D005609:Free Radicals; D006859:Hydrogen; D003903:Deuterium