Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube.
A 70-year-old woman developed progressive visual loss with compromised visual acuity and visual fields, cells in the anterior chamber and vitreous, attenuated retinal arterioles, and macular edema. She had undergone right oophorectomy and partial salpingectomy nearly 50 years earlier. Full-field and multifocal electroretinography showed waveforms of markedly attenuated amplitudes, findings consistent with cancer-associated retinopathy (CAR). Positron emission tomography revealed a nodule in the anterior wall of a right hydrosalpinx. Total laparoscopic hysterectomy yielded a neuroendocrine fallopian tube malignancy. She underwent partial treatment with paclitaxel and carboplatin that was aborted because of the development of herpes zoster infection. At 15 months following diagnosis, her ophthalmic status was stable. This is the first report of CAR in neuroendocrine carcinoma of the fallopian tube.
Raghunath
Anitha
A
Department of Ophthalmology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.
Adamus
Grazyna
G
Bodurka
Diane C
DC
Liu
Jinsong
J
Schiffman
Jade S
JS
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000188:drug therapy; D005185:Fallopian Tube Neoplasms / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000379:methods; D012164:Retinal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology
D000970:Antineoplastic Agents; D016190:Carboplatin; D017239:Paclitaxel