Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes.
As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr(3) or GaCl(3) resulted in the mononuclear complexes [GaBr(3)(btaH)(2)] (1) and [GaCl(3)(btd)(2)] (2), respectively, while treatment of GaCl(3) with L resulted in the anionic complex (LH)(2)[GaCl(4)] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.
Zanias
Stergios
S
Department of Chemistry, University of Patras, 265 04 Patras, Greece.
Papaefstathiou
Giannis S
GS
Raptopoulou
Catherine P
CP
Papazisis
Konstantinos T
KT
Vala
Vasiliki
V
Zambouli
Dimitra
D
Kortsaris
Alexandros H
AH
Kyriakidis
Dimitrios A
DA
Zafiropoulos
Theodoros F
TF