Trisomy 21 leukemias: finding the hits that matter.
Down syndrome is associated with a markedly increased risk of childhood leukemias, and identification of chromosome 21 sequences that have a role in leukemogenesis may provide insights into critical pathways and suggest targets for therapy and prevention. A study in this issue of Oncogene, defines human chromosome 21 sequences that alter hematopoiesis and induce expression of leukemia-associated markers.
Rabson
A B
AB
Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey (UMDNJ), Robert Wood Johnson Medical School (RWJMS), New Brunswick, NJ 08901, USA. rabsonab@umdnj.edu
D000818:Animals; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000235:genetics; D051379:Mice