Facile formation of N-acyl-oxazolidinone derivatives using acid fluorides.
A mild method is presented for the formation of N-acylated oxazolidinones that employs acid fluorides and mild bases, such as (i)Pr(2)NEt and NEt(3). Optimized reaction conditions for two types of substrates have been developed utilizing either the oxazolidinone itself or the corresponding in situ generated O-silyloxazolidinones resulting in the formation of the desired N-acylated products in high yields of up to 98%.
Schindler
Corinna S
CS
Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
Forster
Patrik M
PM
Carreira
Erick M
EM
D000143:Acids / Q000737:chemistry*; D000215:Acylation; D005459:Fluorides / Q000737:chemistry*; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis*
D000143:Acids; D023303:Oxazolidinones; D005459:Fluorides