title: Trends in in-hospital outcome after percutaneous coronary intervention in the drug-eluting stents era.
abstract: BACKGROUND
  The introduction of drug-eluting stents (DES) dramatically changed the practice of percutaneous coronary intervention (PCI) in the 2000s. Little is known about trends in in-hospital outcome after PCI in the DES era.
  
  
  OBJECTIVE
  The in-hospital outcomes after PCI might be continuously improved over time.
  
  
  METHODS
  We analyzed in-hospital outcomes of 21,667 patients who underwent PCI at Fu Wai Hospital in the past 5 years. The patients were divided into 5 groups according to the time of their intervention: group 1 (June 2004 to May 2005), group 2 (June 2005 to May 2006), group 3 (June 2006 to May 2007), group 4 (June 2007 to May 2008), and group 5 (June 2008 to May 2009).
  
  
  RESULTS
  Procedural success rates for the 5 groups were 93.6%, 95%, 94.4%, 94.2%, and 94.3%, respectively (P = 0.39). Significant reduction in in-hospital major adverse cardiac events (3.1%, 3.4%, 2.8%, 1.6%, and 1.0%, P < 0.001) and need for target-vessel revascularization (2.0%, 2.2%, 1.5%, 0.4%, and 0.2%, P < 0.001) was noted over time, which was associated with a significant increase in use of DES (from 56.6% to 97.0%, P < 0.001). On multivariate analysis, use of DES, dissection during procedure, left main lesion, prior myocardial infarction, and age > or = 65 years were independent predictors of major adverse cardiovascular events.
  
  
  CONCLUSIONS
  There were substantial reductions in in-hospital major adverse cardiac events and target-vessel revascularization over the past 5 years. This reduction was associated with the concurrent increased use of DES.
authors: Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors: Sheng Wen
authors: SW
authors: Liu
authors: Bo
authors: B
authors: Xu
authors: Jue
authors: J
authors: Chen
authors: Feng Huan
authors: FH
authors: Hu
authors: Yong Jian
authors: YJ
authors: Wu
authors: Jian Jun
authors: JJ
authors: Li
authors: Yue Jin
authors: YJ
authors: Yang
authors: Ji Lin
authors: JL
authors: Chen
authors: Run Lin
authors: RL
authors: Gao
authors: Shu Bin
authors: SB
authors: Qiao
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality / Q000639:trends*; D016009:Chi-Square Distribution; D002681:China; D054855:Drug-Eluting Stents; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D011474:Prosthesis Design; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome