title: [Mechanisms of phosphorus and calcium homeostatic disorders in the development of cardiovascular events in patients with chronic renal diseases. The role of fibroblast growth factor 23 and Klotho].
abstract: The paper deals with the analysis of studies of the role of the bone morphogenetic proteins fibroblast growth factor 23 (FGF-23) and Klothno in the development of vascular wall calcification in chronic renal disease (CRD). FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations. There is evidence that there is an association between high serum FGF-23 levels and vascular wall calcification irrespective of the content of phosphorus and parathyroid hormone. Most authors regard FGF-23 as a potential uremic toxin in patients with end-stage CRD. There are data that support the renoprotective value of the morphogenetic protein Klotho whose expression in CRD is decreased.
authors: L Iu
authors: LIu
authors: Milovanova
authors: L V
authors: LV
authors: Kozlovskaia
authors: Iu S
authors: IuS
authors: Milovanov
authors: I N
authors: IN
authors: Bobkova
authors: I A
authors: IA
authors: Dobrosmyslov
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D002908:Chronic Disease; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood / Q000378:metabolism*; D005966:Glucuronidase / Q000096:biosynthesis / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D000090265:Klotho Proteins; D010758:Phosphorus / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium