title: Ubiquilin at a crossroads in protein degradation pathways.
abstract: Ubiquilin proteins are conserved across all eukaryotes and function in the regulation of protein degradation. We found that ubiquilin functions to regulate macroautophagy and that the protein is also a substrate of chaperone-mediated autophagy.
authors: Center for Biomedical Engineering and Technology, Department of Anatomy and Neurology, University of Maryland, Baltimore, Baltimore, MD, USA.
authors: Cara
authors: C
authors: Rothenberg
authors: Mervyn J
authors: MJ
authors: Monteiro
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D001343:Autophagy / Q000502:physiology; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; D018832:Molecular Chaperones; D011506:Proteins; D011993:Recombinant Fusion Proteins; C107792:UBQLN1 protein, human