title: Clinical course and outcome of heart transplant recipients: single center experience at the National Cardiovascular Center in Japan.
abstract: The number of heart transplant (HTx) surgeries in Japan is expected to increase under the Revised Organ Transplant Law. To date, among 69 HTx surgeries performed in Japan, 27 operations (39.1%) were performed at our institution, the National Cardiovascular Center (NCVC), located in Osaka. We have reviewed the outcomes of HTx conducted at NCVC during a 10 year period (May 1999 to January 2009). Among 27 heart transplant recipients at NCVC, the clinical charts of 26 recipients whose post-HTx period exceeded 1 year were retrospectively reviewed and compared to data from the International Society for Heart and Lung Transplantation (ISHLT) Registry. The survival rate of our recipients was 96.2% at 10.8 years, which was excellent even compared to the ISHLT Registry. The immunosuppressive regimen at NCVC was equivalent to that of the ISHLT Registry, except for more frequent use of Muromonab-CD3 (26.9% versus 3.3%, P < 0.0001) and an initial CSA-based regimen (65.3% versus 34.4%, P < 0.001). The drug we use for induction therapy has been recently changed from Muromonab-CD3 to Basiliximab. The incidences of post-HTx hypertension, diabetes, hyperlipidemia, and renal insufficiency were significantly less in patients at NCVC compared to those in the ISHLT Registry, however, the incidence of transplant coronary artery disease (TxCAD) was almost identical. Clinical review of post-HTx outcome at NCVC can provide useful information for Japanese transplant cardiologists who will engage in HTx management.
authors: Department of Cardiovascular Medicine, National Cardiovascular Center, Osaka, Japan.
authors: Noboru
authors: N
authors: Oda
authors: Tomoko S
authors: TS
authors: Kato
authors: Kazuo
authors: K
authors: Komamura
authors: Akihisa
authors: A
authors: Hanatani
authors: Akiko
authors: A
authors: Mano
authors: Kazuhiko
authors: K
authors: Hashimura
authors: Masanori
authors: M
authors: Asakura
authors: Kazuo
authors: K
authors: Niwaya
authors: Toshihiro
authors: T
authors: Funatsu
authors: Junjiro
authors: J
authors: Kobayashi
authors: Kyoichi
authors: K
authors: Wada
authors: Shuji
authors: S
authors: Hashimoto
authors: Hatsue
authors: H
authors: Ishibashi-Ueda
authors: Yukiko
authors: Y
authors: Nakano
authors: Yasuki
authors: Y
authors: Kihara
authors: Masafumi
authors: M
authors: Kitakaze
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000517:prevention & control; D006331:Heart Diseases / Q000150:complications / Q000453:epidemiology* / Q000601:surgery*; D016027:Heart Transplantation; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult