Assembly/disassembly of drug conjugates using imide ligation.
A strategy is described that allows the easy assembly and controlled disassembly of drug conjugates. Imide ligation, that is, the reaction of a peptide thioacid with an azidoformate, is used for conjugate assembly. The imide bond participates also with an endopeptidase-triggered cyclization-based disassembly mechanism.
Mhidia
Reda
R
UMR CNRS 8161, Université de Lille Nord de France, IFR 142, Institut Pasteur de Lille, 1 rue du Pr Calmette 59021 Lille, France.
Bézière
Nicolas
N
Blanpain
Annick
A
Pommery
Nicole
N
Melnyk
Oleg
O
D000595:Amino Acid Sequence; D003500:Cyclization; D010450:Endopeptidases / Q000378:metabolism; D007094:Imides / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry
D007094:Imides; D010455:Peptides; D010450:Endopeptidases