title: Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation.
abstract: Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes.
authors: The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors: Ye-Ping
authors: YP
authors: Yu
authors: Peng
authors: P
authors: Lei
authors: Jia
authors: J
authors: Hu
authors: Wei-Hui
authors: WH
authors: Wu
authors: Yu-Fen
authors: YF
authors: Zhao
authors: Yan-Mei
authors: YM
authors: Li
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D058228:Islet Amyloid Polypeptide / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D058228:Islet Amyloid Polypeptide; D017382:Reactive Oxygen Species; D003300:Copper