[Therapeutic effect of oligonol, a low-molecular polyphenol formulation derived from lychee fruits on murine oral candidiasis].
We assessed the potential of oligonol, a low molecular polyphenol formulation prepared from lychee fruits, for treatment of oral candidiasis using a murine model. Oligonol at concentration of more than 313 microg/ml inhibited the mycelial growth of Candida albicans in vitro. When 50 microl of oligonol (20 mg/ml ) was administered three times into the oral cavity of orally Candida -infected mice, the number of viable Candida cells in the oral cavity was reduced significantly and the score of lesions on the tongue recovered on day 2. These findings suggest that oligonol could have potential as a food component supporting anti- Candida treatment.
Hayama
Kazumi
K
Teikyo University Institute of Medical Mycology.
Ishibashi
Hiroko
H
Kitadate
Kentaro
K
Yamazaki
Masatoshi
M
Abe
Shigeru
S
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D002180:Candidiasis, Oral / Q000188:drug therapy*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*
D000935:Antifungal Agents; D010636:Phenols; C514283:oligonol; D002392:Catechin