title: Ridge preservation with acellular dermal matrix and anorganic bone matrix cell-binding peptide P-15 after tooth extraction in humans.
abstract: BACKGROUND
  Preventing ridge collapse with the extraction of maxillary anterior teeth is vital to an esthetic restorative result. Several regenerative techniques are available and are used for socket preservation. The aim of this study is to analyze by clinical parameters the use of acellular dermal matrix (ADM) and anorganic bovine bone matrix (ABM) with synthetic cell-binding peptide P-15 to preserve alveolar bone after tooth extraction.
  
  
  METHODS
  Eighteen patients in need of extraction of maxillary anterior teeth were selected and randomly assigned to the test group (ADM plus ABM/P-15) or the control group (ADM only). Clinical measurements were recorded initially and at 6 months after ridge-preservation procedures.
  
  
  RESULTS
  In the clinical measurements (external vertical palatal measurement [EVPM], external vertical buccal measurement [EVBM], and alveolar horizontal measurement [AHM]) the statistical analysis showed no difference between test and control groups initially and at 6 months. The intragroup analysis, after 6 months, showed a statistically significant reduction in the measurements for both groups. In the comparison between the two groups, the differences in the test group were as follows: EVPM = 0.83 ± 1.53 mm; EVBM = 1.20 ± 2.02 mm; and AHM = 2.53 ± 1.81 mm. The differences in the control group were as follows: EVPM = 0.87 ± 1.13 mm; EVBM = 1.50 ± 1.15 mm; and AHM = 3.40 ± 1.39 mm. The differences in EVPM and EVBM were not statistically significant; however, in horizontal measurement (AHM), there was a statistically significant difference (P<0.05).
  
  
  CONCLUSIONS
  The results of this study show that ADM used as membrane associated with ABM/P-15 can be used to reduce buccal-palatal dimensions compared to ADM alone for preservation of the alveolar ridge after extraction of anterior maxillary teeth.
authors: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors: Patricia Garani
authors: PG
authors: Fernandes
authors: Arthur B
authors: AB
authors: Novaes
authors: Adriana Correa
authors: AC
authors: de Queiroz
authors: Sergio Luis Scombatti
authors: SL
authors: de Souza
authors: Mario
authors: M
authors: Taba
authors: Daniela Bazan
authors: DB
authors: Palioto
authors: Marcio Fernando de Moraes
authors: MF
authors: Grisi
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000517:prevention & control; D000539:Alveolar Process / Q000473:pathology; D000543:Alveoloplasty / Q000379:methods*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001857:Bone Matrix / Q000637:transplantation*; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D013524:Surgical Flaps; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen