Specific infiltration of langerin-positive dendritic cells in EBV-infected tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma.
We report here the existence of a novel subset of langerin (CD207)-positive, immature dendritic cells (DCs) (CD83(neg) ) abundantly infiltrating Epstein Barr virus (EBV)-infected areas in tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma. These CD207(+) DCs differ from conventional epidermal Langerhans cells in their lack of CD1a and CCR6 and their unusual tissue localization. CD207(+) DC infiltration strongly correlates with EBV infection because it was neither detected in EBV negative specimens nor in tissues infected with other human viruses. These immature DCs might represent good candidates for induction of the EBV-specific immune response.
Braz-Silva
Paulo Henrique
PH
Inserm ERI 21/EA 4319, Université de Nice, Nice, France. doglio@unice.fr
Vitale
Sébastien
S
Butori
Catherine
C
Guevara
Nicolas
N
Santini
José
J
Magalhães
Marina
M
Hofman
Paul
P
Doglio
Alain
A
D015703:Antigens, CD / Q000378:metabolism*; D001483:Base Sequence; D017931:DNA Primers; D003713:Dendritic Cells / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D017403:In Situ Hybridization; D037181:Lectins, C-Type / Q000378:metabolism*; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000378:metabolism*; D014066:Palatine Tonsil / Q000276:immunology / Q000378:metabolism* / Q000821:virology
D015703:Antigens, CD; C121916:CD207 protein, human; D017931:DNA Primers; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins