[Rationale for the use of extracorporeal photochemotherapy in children].
The management of immune diseases in children remains challenging, although significant advances have been made. In addition to pharmacological approaches, extracorporeal photochemotherapy (ECP) is distinctive in its ability to provide immunomodulation without immune suppression or toxicity. However, in practice, this therapy is not widely used because of logistical issues and the lack of robust clinical pediatric studies. Here, we discuss the potential clinical applications of ECP in children and emphasize the need for a rigorous and specifically pediatric clinical evaluation of ECP.
Merlin
E
E
Centre régional de cancérologie et thérapie cellulaire pédiatrique, hôpital Estaing, CHU de Clermont-Ferrand, 63001 Clermont-Ferrand, France. e_merlin@chu-clermontferrand.fr
Kanold
J
J
Hannani
D
D
Terral
D
D
D'Incan
M
M
Deméocq
F
F
D001327:Autoimmune Diseases / Q000628:therapy*; D002648:Child; D019317:Evidence-Based Medicine; D006086:Graft vs Host Disease / Q000628:therapy*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D017893:Photopheresis; D016896:Treatment Outcome