title: Lung function and blood markers of nutritional status in non-COPD aging men with smoking history: a cross-sectional study.
abstract: OBJECTIVE
  Cigarette smoking and advanced age are well known as risk factors for chronic obstructive pulmonary disease (COPD), and nutritional abnormalities are important in patients with COPD. However, little is known about the nutritional status in non-COPD aging men with smoking history. We therefore investigated whether reduced lung function is associated with lower blood markers of nutritional status in those men.
  
  
  METHODS
  This association was examined in a cross-sectional study of 65 Japanese male current or former smokers aged 50 to 80 years: 48 without COPD (non-COPD group), divided into tertiles according to forced expiratory volume in one second as percent of forced vital capacity (FEV(1)/FVC), and 17 with COPD (COPD group).
  
  
  RESULTS
  After adjustment for potential confounders, lower FEV(1)/FVC was significantly associated with lower red blood cell count (RBCc), hemoglobin, and total protein (TP); not with total energy intake. The difference in adjusted RBCc and TP among the non-COPD group tertiles was greater than that between the bottom tertile in the non-COPD group and the COPD group.
  
  
  CONCLUSIONS
  In non-COPD aging men with smoking history, trends toward reduced nutritional status and anemia may independently emerge in blood components along with decreased lung function even before COPD onset.
authors: Department of Geriatric Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Misasa, Tottori, Japan.
authors: Nobuyoshi
authors: N
authors: Shiozawa
authors: Kanae
authors: K
authors: Hayashimoto
authors: Etsuji
authors: E
authors: Suzuki
authors: Hiroshi
authors: H
authors: Kikuchi
authors: Shingo
authors: S
authors: Takata
authors: Kozo
authors: K
authors: Ashida
authors: Masutaka
authors: M
authors: Watanabe
authors: Yasuhiro
authors: Y
authors: Hosaki
authors: Fumihiro
authors: F
authors: Mitsunobu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D003430:Cross-Sectional Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D029424:Pulmonary Disease, Chronic Obstructive; D012129:Respiratory Function Tests; D012907:Smoking / Q000378:metabolism*; D014797:Vital Capacity / Q000502:physiology
chemical_list: D015415:Biomarkers