Synthesis and biological property of some novel 1,3,4-oxadiazoles.
A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1'-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity.
Ramaprasad
G C
GC
Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India.
Kalluraya
Balakrishna
B
Kumar
B Sunil
BS
Hunnur
Ravindra K
RK
D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D005260:Female; D005658:Fungi / Q000187:drug effects; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement / Q000187:drug effects; D013329:Structure-Activity Relationship
D000700:Analgesics; D000890:Anti-Infective Agents; D010069:Oxadiazoles