Albuminuria is the stronger risk factor for peripheral arterial disease than eGFR decline in a type 2 diabetic Taiwanese population.
BACKGROUND
Several studies have shown the identified risk factors for peripheral arterial disease in individuals with diabetes, but relatively little information has been provided regarding the risk factors for peripheral arterial disease especially in individuals with renal insufficiency and albuminuria.


OBJECTIVE
In our study, we attempted to determine whether peripheral arterial disease is related to the reduction of estimated glomerular filtration rate (eGFR) or albuminuria in type 2 diabetic patients if both were measured.


METHODS
We included 478 type 2 diabetic patients that were more than 50 years old in this study and determined their urine albumin to creatinine ratio and eGFR. The ankle-brachial index was measured.


RESULTS
We found a prevalence of peripheral arterial disease of 12 and 11.7% in the normoalbuminuria and >90 ml/min/1.73 m² eGFR group. Simple logistic regression analysis showed that both macroalbuminuria and eGFR <60 ml/min/1.73 m² were significantly associated with peripheral arterial disease individually, but most interestingly in the multiple logistic regression analysis, macroalbuminuria and age are independent factors for peripheral arterial disease with a p value of 0.012 (β = 1.014) and <0.001 (β = 0.107), respectively.


CONCLUSIONS
In summary, our study indicates that macroalbuminuria is a stronger indicator for peripheral arterial disease than eGFR <60 ml/min/1.73 m² in a type 2 diabetic population older than 50 years of age.
Lee
Mei Yueh
MY
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
Lin
Kun-Der
KD
Chang
Yu-Hung
YH
Hsiao
Pi-Jung
PJ
Shin
Shyi-Jang
SJ
D000367:Age Factors; D000368:Aged; D000419:Albuminuria / Q000150:complications*; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000209:etiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan