title: Cooperative and uncooperative cyclic-nucleotide-gated ion channels.
abstract: Ion channels gated by cyclic nucleotides serve multiple functions in sensory signaling in diverse cell types ranging from neurons to sperm. Newly discovered members from bacteria and marine invertebrates provide a wealth of structural and functional information on this channel family. A hallmark of classical tetrameric cyclic-nucleotide-gated channels is their cooperative activation by binding of several ligands. By contrast, the new members seem to be uncooperative, and binding of a single ligand molecule suffices to open these channels. These new findings provide a fresh look at the mechanism of allosteric activation of ion channels.
authors: Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors: Abhishek
authors: A
authors: Cukkemane
authors: Reinhard
authors: R
authors: Seifert
authors: U Benjamin
authors: UB
authors: Kaupp
mesh_terms: D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000737:chemistry / Q000378:metabolism*; D015640:Ion Channel Gating; D008024:Ligands; D011485:Protein Binding
chemical_list: D054815:Cyclic Nucleotide-Gated Cation Channels; D008024:Ligands