Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three.
BACKGROUND
There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma.


OBJECTIVE
To investigate the risk of asthma and other allergic disorders associated with the current use of acetaminophen in 13- to 14-year-old children in different populations worldwide.


METHODS
As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three, 13- to 14-year-old children completed written and video questionnaires obtaining data on current symptoms of asthma, rhinoconjunctivitis, and eczema, and a written environmental questionnaire obtaining data on putative risk factors, including acetaminophen use in the past 12 months.


RESULTS
The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression. A total of 322,959 adolescent children from 113 centers in 50 countries participated. In the multivariate analyses the recent use of acetaminophen was associated with an exposure-dependent increased risk of current asthma symptoms (OR, 1.43 [95% confidence interval, 1.33-1.53] and 2.51 [95% confidence interval, 2.33-2.70] for medium and high versus no use, respectively). Acetaminophen use was also associated with an exposure-dependent increased risk of current symptoms of rhinoconjunctivitis and eczema.


CONCLUSIONS
Acetaminophen use may represent an important risk factor for the development and/or maintenance of asthma, rhinoconjunctivitis, and eczema in adolescent children.
Beasley
Richard W
RW
Medical Research Institute of New Zealand, Private Bag 7902, Wellington 6242, New Zealand. Richard.Beasley@mrinz.ac.nz
Clayton
Tadd O
TO
Crane
Julian
J
Lai
Christopher K W
CK
Montefort
Stephen R
SR
Mutius
Erika von
Ev
Stewart
Alistair W
AW
D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced / Q000453:epidemiology*; D015984:Causality; D015331:Cohort Studies; D003231:Conjunctivitis / Q000139:chemically induced / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004342:Drug Hypersensitivity / Q000453:epidemiology*; D004485:Eczema / Q000139:chemically induced / Q000453:epidemiology*; D005260:Female; D014943:Global Health; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012220:Rhinitis / Q000139:chemically induced / Q000453:epidemiology*; D012307:Risk Factors; D011795:Surveys and Questionnaires
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen