title: PINCH protein expression in normal endometrium, atypical endometrial hyperplasia and endometrioid endometrial carcinoma.
abstract: BACKGROUND
  Particularly interesting new cysteine-histidine rich protein (PINCH), as an adapter protein of the LIM family for signal transduction in the integrin and growth factor pathway, is upregulated in the stroma of several common types of cancers and involved in promoting tumor progression. In the present study, we examined PINCH expression in normal endometrium, atypical endometrial hyperplasia and endometrioid carcinoma, and further studied the relationships of PINCH expression with clinicopathological variables in cancer patients.
  
  
  METHODS
  PINCH expression was examined by immunohistochemistry in 23 normal endometrial samples, 18 atypical endometrial hyperplasias and 48 endometrioid endometrial carcinomas.
  
  
  RESULTS
  The PINCH expression in the stroma of cancer (71%) was significantly increased compared to either normal endometrium (17%, p < 0.0001) or atypical hyperplasia (39%, p = 0.017), along with 9 cancers that had stronger PINCH expressions at the invasive margin of the cancers compared to the inner cancers. PINCH expression in cancer was higher in the patients with hypertension (p = 0.041) and estrogen exposure time >30 years (p = 0.021). On the other hand, PINCH expression was not related to menopausal status, gravid status, blood sugar/lipid, family background of cancer, histological grade, myometrial invasion, cervical involvement, lymph nodal metastases, growth pattern, estrogen and progestogen receptors (p > 0.05). conclusion: The results suggest that PINCH seems to play a role, presently unknown, in the tumorigenesis and development of endometrial cancer that merits further study.
authors: Department of Obstetrics and Gynaecology, First Hospital of Hebei Medical University, Shijiazhuang, China.
authors: Hong-Zhen
authors: HZ
authors: Zhang
authors: Xue-Hui
authors: XH
authors: Li
authors: Xia
authors: X
authors: Zhang
authors: Zhi-Yong
authors: ZY
authors: Zhang
authors: Ya-Li
authors: YL
authors: Meng
authors: Shu-Wen
authors: SW
authors: Xu
authors: Yan
authors: Y
authors: Zheng
authors: Zhen-Long
authors: ZL
authors: Zhu
authors: Dong-Sheng
authors: DS
authors: Cui
authors: Li-Xia
authors: LX
authors: Huang
authors: Bao-Yong
authors: BY
authors: Yan
authors: Xiao-Feng
authors: XF
authors: Sun
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004714:Endometrial Hyperplasia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007150:Immunohistochemistry; D060588:LIM Domain Proteins; D008565:Membrane Proteins; D008875:Middle Aged; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D004967:Estrogens; D060588:LIM Domain Proteins; C088088:LIMS1 protein, human; D008565:Membrane Proteins