title: Cellular mechanisms of aminoglycoside ototoxicity.
abstract: OBJECTIVE
  To summarize advances in the study of the interaction between sensory hair cells and aminoglycoside antibiotics.
  
  
  RESULTS
  Aminoglycosides enter hair cells through mechanotransduction channels and initiate an active signaling pathway that leads to cell death. Early expression of heat shock proteins can protect hair cells from aminoglycosides, although signaling from surrounding supporting cells appears to promote hair cell death. Studies of certain human deafness mutations have revealed new insights into the role of mitochondria in aminoglycoside ototoxicity.
  
  
  CONCLUSIONS
  The cellular mechanisms of aminoglycoside ototoxicity continue to be an active topic of research and newly developed animal models offer great promise for future advances. Nevertheless, proven clinical methods for the prevention of ototoxic injury are not yet available.
authors: Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA. warcholm@ent.wustl.edu
authors: Mark E
authors: ME
authors: Warchol
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006198:Hair Cells, Auditory / Q000187:drug effects*; D006801:Humans
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents