Recurrent infective endocarditis due to Aggregatibacter actinomycetemcomitans: reinfection or relapse?
Aggregatibacter actinomycetemcomitans is commonly part of the normal microflora of the human upper respiratory tract. It has been implicated in periodontal disease and various infections, particularly endocarditis. We report here what we believe to be the first case of recurrent infective endocarditis due to A. actinomycetemcomitans in a 44-year-old woman occurring 5 years after the initial episode. Genomic analysis proved that the strains were closely related. Despite efficient antibiotic treatment, surgery was necessary for recovery.
Potron
Anais
A
AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.|AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
Mainardi
Jean-Luc
JL
INSERM, UMR S 872 - Equipe 12, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Centre de Recherche Biomédical des Cordeliers, Université Paris Descartes et UPMC, Paris, France.|Université Paris Descartes, Faculté de Médecine, Paris, France.|AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.
Podglajen
Isabelle
I
INSERM, UMR S 872 - Equipe 12, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Centre de Recherche Biomédical des Cordeliers, Université Paris Descartes et UPMC, Paris, France.|Université Paris Descartes, Faculté de Médecine, Paris, France.|AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.
Meunier
Fabienne
F
AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
Sanson-le Pors
Marie-José
MJ
Université Paris Diderot, Faculté de Médecine, Paris VII, France.|AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
Berçot
Béatrice
B
Université Paris Diderot, Faculté de Médecine, Paris VII, France.|AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D005260:Female; D016680:Genome, Bacterial; D006801:Humans; D015661:Pasteurellaceae / Q000145:classification* / Q000235:genetics; D016871:Pasteurellaceae Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D012008:Recurrence
D000900:Anti-Bacterial Agents