Remote amide-directed palladium-catalyzed benzylic C-H amination with N-fluorobenzenesulfonimide.
An unprecedented remote amide-directed palladium-catalyzed intermolecular highly selective benzylic C-H amination with N-fluorobenzenesulfonimide is developed, which represents the first direct benzylic C-H amination with a non-nitrene nitrogen source. This methodology provides a novel approach to circumvent the common ortho aromatic C-H selectivity in directed palladium catalyzed C-H functionalization.
Xiong
Tao
T
Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Li
Yan
Y
Lv
Yunhe
Y
Zhang
Qian
Q