fMRI BOLD response of high-risk college students (Part 2): during memory priming of alcohol, marijuana and polydrug picture cues.
OBJECTIVE
This study examined brain activity using functional magnetic resonance imaging (fMRI) and reaction time (RT) during an implicit repetition priming memory task involving alcohol, polydrug, marijuana and emotional picture cues.


METHODS
Participants were 5 male and 5 female high-risk college students who had just participated in a cue exposure study (Ray et al., this issue). fMRI and RT data were collected while participants made decisions about previously seen and new picture cues.


RESULTS
Both behavioral RT and brain imaging data revealed strong memory priming for drug and alcohol cues. Neurologically, a repetition priming effect (suppression in neural activity for repeated cues) was observed in response to alcohol cues in the left prefrontal, bilateral occipital, and bilateral occipitotemporal regions, as well as right insula and right precuneus (Z ranged from 3.03 to 3.31 P < 0.05). Polydrug cues elicited priming in the occipital and temporal areas, and marijuana cues in the occipital area.


CONCLUSIONS
Prefrontal and insular cortex involvement both in reactivity to alcohol cues (Ray et al., this issue) and subsequent implicit memory processing of these cues, as found in this study, suggests their potential role in the maintenance of high-risk alcohol use behaviors.
Ray
Suchismita
S
Center of Alcohol Studies, Rutgers-The State University of New Jersey, 607 Allison Road, Piscataway, NJ 08854, USA. shmita@rci.rutgers.edu
Hanson
Catherine
C
Hanson
Stephen J
SJ
Rahman
Rifaquat M
RM
Bates
Marsha E
ME
D000428:Alcohol Drinking / Q000523:psychology; D003463:Cues; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008385:Marijuana Smoking / Q000523:psychology; D008568:Memory / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods*; D011930:Reaction Time / Q000502:physiology*; D013334:Students / Q000523:psychology*; D019966:Substance-Related Disorders / Q000523:psychology*; D055815:Young Adult