title: Effect of goniothalamin on the development of Ehrlich solid tumor in mice.
abstract: In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself.
authors: Programa de Pós-graduação em Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil.
authors: Débora Barbosa
authors: DB
authors: Vendramini-Costa
authors: Ilton Barros Daltro
authors: IB
authors: de Castro
authors: Ana Lúcia Tasca Góis
authors: AL
authors: Ruiz
authors: Cilene
authors: C
authors: Marquissolo
authors: Ronaldo Aloise
authors: RA
authors: Pilli
authors: João Ernesto
authors: JE
authors: de Carvalho
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002351:Carrageenan / Q000633:toxicity; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D051379:Mice; D011753:Pyrones / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D013237:Stereoisomerism
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D011753:Pyrones; C103280:goniothalamin; D002351:Carrageenan