title: Substituted pyrroles via olefin cross-metathesis.
abstract: Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK. timothy.donohoe@chem.ox.ac.uk
authors: Timothy J
authors: TJ
authors: Donohoe
authors: Nicholas J
authors: NJ
authors: Race
authors: John F
authors: JF
authors: Bower
authors: Cedric K A
authors: CK
authors: Callens