title: The active implementation of pregnancy hypertension guidelines in British Columbia.
abstract: OBJECTIVE
  To reduce maternal and perinatal morbidity and mortality associated with the hypertensive disorders of pregnancy by using an active model of guideline implementation.
  
  
  METHODS
  This study used a preintervention and postintervention cohort comparison design. We interrogated the British Columbia Perinatal Database Registry for 6 years of existing prospectively gathered data (fiscal years 2000-2001 to 2005-2006), introduced the hypertensive disorders of pregnancy guidelines, and assessed the incidence of the combined adverse maternal and perinatal outcomes for the next 2 years (fiscal years 2006-2007 and 2007-2008). The combined adverse maternal outcome was maternal death, life-threatening, or life-altering complications. The combined perinatal outcome included the severe complications of prematurity and hypoxic-ischemic encephalopathy.
  
  
  RESULTS
  Eighteen thousand seventy-six women were diagnosed with hypertensive disorder of pregnancy in British Columbia from 2000-2001 to 2007-2008. Outcomes were compared preguideline (n=13,150 deliveries) and postguideline (n=4,926 deliveries) implementation. The incidence of the combined adverse maternal outcome decreased from 3.1% to 1.9% (relative risk 0.60, 95% confidence interval 0.48-0.75). There was a concomitant fall in the incidence of the combined adverse perinatal outcome.
  
  
  CONCLUSIONS
  The active introduction of standardized management of women with a hypertensive disorder of pregnancy is associated with reduced maternal and perinatal risk.
  
  
  METHODS
  II.
authors: From the Departments of Obstetrics and Gynaecology, Anesthesiology, Pharmacology and Therapeutics, and Medicine, School of Public and Population Health, Child and Family Research Institute, and Faculty of Medicine, University of British Columbia, and the BC Perinatal Health Program, Vancouver, British Columbia, Canada; and the Department of Paediatrics, University of Toronto, Ontario, Canada.
authors: Peter
authors: P
authors: von Dadelszen
authors: Diane
authors: D
authors: Sawchuck
authors: Romy
authors: R
authors: McMaster
authors: M Joanne
authors: MJ
authors: Douglas
authors: Shoo K
authors: SK
authors: Lee
authors: Sarah
authors: S
authors: Saunders
authors: Robert M
authors: RM
authors: Liston
authors: Laura A
authors: LA
authors: Magee
mesh_terms: D000328:Adult; D001955:British Columbia / Q000453:epidemiology; D005260:Female; D019983:Guideline Adherence; D006764:Hospitals, Community / Q000706:statistics & numerical data; D006771:Hospitals, Maternity / Q000706:statistics & numerical data; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology / Q000628:therapy*; D011247:Pregnancy; D055815:Young Adult