title: Assessment of bone healing after Le Fort I osteotomy with 3-dimensional computed tomography.
abstract: OBJECTIVE
  The purpose of this study was to examine bone healing after Le Fort I osteotomy in Class III patients.
  
  
  METHODS
  The study group consisted of 18 Japanese patients with mandibular prognathism with and without asymmetry, maxillary retrognathism or open bite. A total of 36 sides were examined. Le Fort I osteotomy was performed without a pterygoid osteotome, with an ultrasonic curette used to remove interference at the pterygomaxillary region. Titanium plates (Universal Mid-face fixation module, Stryker, Freiburg, German) were used for four patients, absorbable plates (poly-L-lactic acid (PLLA): NEOFIX(®), Gunze, kyoto, Japan) were used for four patients and other absorbable plates (uncalcined and unsintered hydroxyapatite and poly-L-lactic acid (uHA/PLLA): super FIXSORB(®)MX, Takiron Co. Ltd, Osaka, Japan) were used for 10 patients, in the same manner. Postoperative computed tomography (CT) was analyzed for all patients pre-operatively and 1 year postoperative. The anterior and lateral areas between the maxillary segments were measured with 3-dimensional (3D) CT. Bone healing at the pterygomaxillary region was also assessed.
  
  
  RESULTS
  There were no significant differences in the area of bone defect healing among the plate types. The areas of bone defect after 1 year were significantly smaller than that immediately after surgery on the right side (p=0.0145) and left side (p=0.0010) in the frontal view and right side in the lateral view (p=0.0118). Bone healing at the pterygomaxillary junction was found in all cases without artificial pterygoid plate fracture. Fourteen of 22 sides with artificial pterygoid plate fracture by an ultrasonic curette showed bone continuity between the pterygoid plate and posterior part of maxilla.
  
  
  CONCLUSIONS
  This study suggested that bony healing could occur in spaces between the segments of maxilla and pterygomaxillary regions as well as the region of the anterior and lateral walls in the maxilla, but it is not always complete within 1 year after Le Fort I osteotomy.
authors: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan. kueki@med.kanazawa-u.ac.jp
authors: Koichiro
authors: K
authors: Ueki
authors: Mao
authors: M
authors: Miyazaki
authors: Katsuhiko
authors: K
authors: Okabe
authors: Aya
authors: A
authors: Mukozawa
authors: Kohei
authors: K
authors: Marukawa
authors: Akinori
authors: A
authors: Moroi
authors: Kiyomasa
authors: K
authors: Nakagawa
authors: Etsuhide
authors: E
authors: Yamamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D001860:Bone Plates; D001861:Bone Regeneration / Q000502:physiology*; D017886:Durapatite; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007564:Japan; D019344:Lactic Acid; D008297:Male; D008313:Malocclusion, Angle Class III / Q000601:surgery*; D008437:Maxilla / Q000502:physiology / Q000601:surgery*; D024343:Open Bite / Q000601:surgery; D019340:Osteotomy, Le Fort / Q000379:methods; D017063:Outcome Assessment, Health Care; D011091:Polyesters; D011108:Polymers; D063173:Retrognathia / Q000601:surgery; D013100:Sphenoid Bone / Q000601:surgery; D013997:Time Factors; D014025:Titanium; D014057:Tomography, X-Ray Computed / Q000379:methods; D014465:Ultrasonics; D014945:Wound Healing / Q000502:physiology*; D055815:Young Adult
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite; D014025:Titanium