Induced domain formation in endocytic invagination, lipid sorting, and scission.
Lipid segregation occurs in biological membranes, but how this plays into cellular processes like endocytosis has been unclear. Here, we discuss how the active or passive induction of lipid-protein domain formation in membranes can alter membrane mechanics and thus affect processes such as the generation of curvature, the scission of buds and tubules, and lipid sorting.
Johannes
Ludger
L
Institut Curie, Centre de Recherche, Traffic, Signaling, and Delivery Laboratory, 75248 Paris Cedex 05, France. mayor@ncbs.res.in
Mayor
Satyajit
S
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002468:Cell Physiological Phenomena; D004705:Endocytosis; D006801:Humans; D050356:Lipid Metabolism