title: International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins.
abstract: The 2009 International Society of Urological Pathology Consensus Conference in Boston, made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to surgical margin assessment were coordinated by working group 5. Pathologists agreed that tumor extending close to the 'capsular' margin, yet not to it, should be reported as a negative margin, and that locations of positive margins should be indicated as either posterior, posterolateral, lateral, anterior at the prostatic apex, mid-prostate or base. Other items of consensus included specifying the extent of any positive margin as millimeters of involvement; tumor in skeletal muscle at the apical perpendicular margin section, in the absence of accompanying benign glands, to be considered organ confined; and that proximal and distal margins be uniformly referred to as bladder neck and prostatic apex, respectively. Grading of tumor at positive margins was to be left to the discretion of the reporting pathologists. There was no consensus as to how the surgical margin should be regarded when tumor is present at the inked edge of the tissue, in the absence of transected benign glands at the apical margin. Pathologists also did not achieve agreement on the reporting approach to benign prostatic glands at an inked surgical margin in which no carcinoma is present.
authors: Department of Pathology, Singapore General Hospital, Singapore, Singapore. tan.puay.hoon@sgh.com.sg
authors: Puay Hoon
authors: PH
authors: Tan
authors: Liang
authors: L
authors: Cheng
authors: John R
authors: JR
authors: Srigley
authors: David
authors: D
authors: Griffiths
authors: Peter A
authors: PA
authors: Humphrey
authors: Theodore H
authors: TH
authors: van der Kwast
authors: Rodolfo
authors: R
authors: Montironi
authors: Thomas M
authors: TM
authors: Wheeler
authors: Brett
authors: B
authors: Delahunt
authors: Lars
authors: L
authors: Egevad
authors: Jonathan I
authors: JI
authors: Epstein
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012955:Societies, Medical; D013048:Specimen Handling / Q000379:methods*; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery