title: Postdiagnosis diet quality is inversely related to a biomarker of inflammation among breast cancer survivors.
abstract: BACKGROUND
  Inflammation and immune response have potential prognostic implications for breast cancer survivors. We examined how postdiagnosis diet quality is cross-sectionally related to biomarkers of inflammation and adipose-derived hormones among breast cancer survivors and determined whether physical activity or body size modified any observed associations.
  
  
  METHODS
  Participants included 746 women diagnosed with stage 0 to IIIA breast cancer. Thirty months after diagnosis, the women completed food frequency questionnaires. We scored diet quality with the Healthy Eating Index (HEI)-2005. Serum concentrations of C-reactive protein (CRP), serum amyloid A, leptin, and adiponectin were measured in fasting 30 mL blood samples. Log biomarker values were regressed on quartiles of HEI-2005 scores in multivariate models, and beta scores were exponentiated and expressed as geometric means within quartiles of HEI-2005 scores.
  
  
  RESULTS
  Women with better versus poor quality postdiagnosis diets, as defined by higher HEI-2005 scores (Q4 versus Q1), had lower concentrations of CRP (1.6 mg/L versus 2.5 mg/L), but no significant difference in concentrations of serum amyloid A, leptin, or adiponectin. Among women not engaging in recreational physical activity after diagnosis, better diet quality was associated with lower CRP concentrations (2.5 mg/L versus 5.0 mg/L), but no association was observed among women engaging in any recreational physical activity (1.4 mg/L versus 1.6 mg/L; P heterogeneity = 0.03).
  
  
  CONCLUSIONS
  Among breast cancer survivors, a better-quality diet seems to be associated with lower levels of chronic inflammation.
  
  
  CONCLUSIONS
  Lower levels of chronic inflammation have been associated with improved survival after breast cancer.
authors: Yale School of Public Health, Division of Chronic Disease Epidemiology, New Haven, Connecticut, USA. materess@mail.nih.gov
authors: Stephanie M
authors: SM
authors: George
authors: Marian L
authors: ML
authors: Neuhouser
authors: Susan T
authors: ST
authors: Mayne
authors: Melinda L
authors: ML
authors: Irwin
authors: Demetrius
authors: D
authors: Albanes
authors: Mitchell H
authors: MH
authors: Gail
authors: Catherine M
authors: CM
authors: Alfano
authors: Leslie
authors: L
authors: Bernstein
authors: Anne
authors: A
authors: McTiernan
authors: Jill
authors: J
authors: Reedy
authors: Ashley W
authors: AW
authors: Smith
authors: Cornelia M
authors: CM
authors: Ulrich
authors: Rachel
authors: R
authors: Ballard-Barbash
mesh_terms: D052242:Adiponectin / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D004032:Diet; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009043:Motor Activity; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D000685:Serum Amyloid A Protein / Q000378:metabolism; D011795:Surveys and Questionnaires; D017741:Survivors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D014408:Biomarkers, Tumor; D020738:Leptin; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein