title: What can surveillance of genital warts tell us?
abstract: In this Review, we describe the recent epidemiology of genital warts and postulate what the future may hold as a result of the introduction of the quadrivalent human papillomavirus (HPV) vaccine. HPV types 6 or 11 are responsible for most cases and they develop in about two-thirds of women a few months after HPV 6 or 11 infections are first detected by polymerase chain reaction. Surveillance data, cohort studies and cross-sectional surveys suggest that the annual incidence of genital warts exceeds 1% and serological studies suggest cumulative risk up to 40 years of age for HPV 6 or 11 is over 25%. The quadrivalent HPV vaccine is highly effective against genital warts and Australian surveillance data in the 2 years after the introduction of the vaccine have shown large declines in younger women and to a lesser degree heterosexual men. No significant changes in older women or men who have sex with men were seen. Given the success of Australia's catch-up program it will not be long before we know if the basic reproductive number for genital warts holds the prospect of elimination. However, if genital warts stabilise at a lower, but not very low, rate we will know that elimination will not be possible without vaccination of males.
authors: Melbourne Sexual Health Centre, Vic. 3053, Australia. cfairley@unimelb.edu.au
authors: Christopher K
authors: CK
authors: Fairley
authors: Basil
authors: B
authors: Donovan
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia; D003218:Condylomata Acuminata / Q000453:epidemiology* / Q000517:prevention & control*; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005260:Female; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D052163:Human papillomavirus 6; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D011159:Population Surveillance; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology* / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D053918:Papillomavirus Vaccines