title: Effective construction of quaternary stereocenters by highly enantioselective α-amination of branched aldehydes.
abstract: A highly efficient enantioselective α-amination of branched aldehydes with azadicarboxylates promoted by chiral proline-derived amide thiourea bifunctional catalysts was developed for the first time, affording the adducts bearing quaternary stereogenic centers with excellent yields (up to 99%) and enantioselectivities (up to 97% ee).
authors: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China, PR.
authors: Ji-Ya
authors: JY
authors: Fu
authors: Xiao-Ying
authors: XY
authors: Xu
authors: Yan-Chun
authors: YC
authors: Li
authors: Qing-Chun
authors: QC
authors: Huang
authors: Li-Xin
authors: LX
authors: Wang