title: Interrelationship between oxygen-related variables in patients with acute myocardial infarction: an interpretative review.
abstract: The high mortality rate of cardiogenic shock in acute myocardial infarction (AMI) implies that debate over the correct haemodynamic management is still unresolved. The purpose of this review is to re-evaluate the reciprocal relationships between oxygen-related variables and response to treatment in a large number of patients with AMI. A MEDLINE search of reports published between 1970 and 2008 was performed. Twelve clinical reports including 453 patients with AMI and 989 sets of oxygen delivery and oxygen consumption expressed in ml min⁻¹ m⁻² and oxygen extraction ratio were selected. While processing this data, we found an early down-regulation in oxygen demand linked to a decrease in oxygen supply. This mechanism is also supported in some studies by a critically low oxygen uptake that was not associated with lactic acidosis.
authors: Intensive Care Unit, Hospital de Clínicas, University Hospital, Buenos Aires, Argentina. mialjorge@yahoo.com
authors: Miguel A
authors: MA
authors: Jorge
authors: Margarita
authors: M
authors: Tavella
authors: Célica L
authors: CL
authors: Irrazábal
authors: Jorge G
authors: JG
authors: Peralta
authors: Abelardo A
authors: AA
authors: Capdevila
mesh_terms: D000222:Adaptation, Physiological; D000368:Aged; D000369:Aged, 80 and over; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy; D012770:Shock, Cardiogenic / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
chemical_list: D010100:Oxygen