A case of tuberculous peritonitis in a hemodialysis patient with high serum soluble interleukin-2 receptor and CA-125 levels.
A hemodialysis patient with tuberculous peritonitis with hypercalcemia and high serum soluble interleukin-2 receptor (sIL-2R) and CA-125 levels is reported. An 82-year-old woman who had been on hemodialysis therapy for 6 years was admitted to our hospital for evaluation and treatment of hypercalcemia. Laboratory examination and radiologic studies revealed markedly increased serum sIL-2R and CA-125 levels and exudative ascites, with high levels of adenosine deaminase (ADA) and CA-125, which was suggestive of malignancy or tuberculosis. She was finally diagnosed as having tuberculous peritonitis based on positivity for Mycobacterium tuberculosis in ascitic fluid. The ascites subsided with normalization of hypercalcemia and a marked decrease in serum sIL-2R and CA-125 levels in response to anti-tuberculosis treatment. This case indicates that serum sIL-2R and CA-125 levels can rise to levels suggestive of malignancy in tuberculous peritonitis, and that they can be used to monitor the response to anti-tuberculosis treatment.
Kuno
Yoshihiro
Y
Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
Iyoda
Masayuki
M
Aoshima
Yumie
Y
Hosaka
Nozomu
N
Sanada
Daisuke
D
Hirai
Yuki
Y
Shibata
Takanori
T
Akizawa
Tadao
T
D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D014395:Peritonitis, Tuberculous / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D015375:Receptors, Interleukin-2 / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects*; D012995:Solubility
D015415:Biomarkers; D018394:CA-125 Antigen; D015375:Receptors, Interleukin-2