title: Brain immunohistopathological study in a patient with anti-NMDAR encephalitis.
abstract: OBJECTIVE
  Anti-N-methyl-D-asparate (NMDA) receptor encephalitis is thought to be antibody-mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti-NMDA receptor encephalitis.
  
  
  METHODS
  An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies.
  
  
  RESULTS
  Prominent B-cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma.
  
  
  CONCLUSIONS
  These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.
authors: Service de Neurologie, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
authors: J-P
authors: JP
authors: Camdessanché
authors: N
authors: N
authors: Streichenberger
authors: G
authors: G
authors: Cavillon
authors: V
authors: V
authors: Rogemond
authors: G
authors: G
authors: Jousserand
authors: J
authors: J
authors: Honnorat
authors: P
authors: P
authors: Convers
authors: J-C
authors: JC
authors: Antoine
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000009:adverse effects / Q000097:blood; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology* / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002536:Cerebral Arteries / Q000276:immunology / Q000473:pathology; D004660:Encephalitis / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D020293:Vasculitis, Central Nervous System / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate