title: Radiographic enlargement of mandibular canal as first feature of non-Hodgkin's lymphoma.
abstract: Non-Hodgkin's lymphoma has the propensity to affect non-lymphoid tissue including oral tissue. Primary non-Hodgkin's lymphoma of the mandible mistreated as chronic periodontitis with diffuse enlargement of the mandibular canal and ice-cold numbness is very rarely described in English medical literature. A 57-year-old patient presented with a painful swelling on the left side of the mandible with a clinically chronic periodontitis associated with ice-cold numbness. A panoramic radiograph showed a diffuse uniform enlargement of the mandibular canal. Histological examination showed that the lesion was a primary intraosseous non-Hodgkin's lymphoma of the mandible. Immunohistochemical examination showed a positive reaction for CD20+, Ki-67+. Seven months after chemotherapy the patient was observed for possible life-threatening propagation of the disease. In conclusion, primary (extra-nodal) non-Hodgkin's lymphoma of the mandible usually clinically presents with bone swelling, teeth mobility and neurological disturbance. Radiographic features presenting as diffuse enlargement of the mandibular canal could be considered as non-Hodgkin's lymphoma.
authors: Department of Oral and Maxillofacial Surgery, University of Nis School of Medicine and Stomatology, Serbia. nburic@yahoo.com
authors: N
authors: N
authors: Buric
authors: G
authors: G
authors: Jovanovic
authors: Z
authors: Z
authors: Radovanovic
authors: M
authors: M
authors: Buric
authors: M
authors: M
authors: Tijanic
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D019394:Ki-67 Antigen / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008339:Mandibular Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008340:Mandibular Nerve / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010518:Periodontitis / Q000175:diagnosis; D011241:Prednisone / Q000627:therapeutic use; D011858:Radiographic Magnification; D013697:Thermosensing; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D019394:Ki-67 Antigen; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone