title: [Identification of sibling sisters using STR and SNP].
abstract: OBJECTIVE
  The methods for identification of sibling sisters were explored with detection of genetic markers on autochromosome and X-chromosome.
  
  
  METHODS
  Genomic DNA of the sibling sisters were extracted, and 15 STRs on autochromosome and 17 STRs on X-chromosome were genotyped by Sinofiler kit, Mentype Argus X-8 kit and in-house kit of X-STRs, respectively. 11 X-SNPs were genotyped with TaqMan technology.
  
  
  RESULTS
  Full sibling relationship of the test samples were confirmed by calculating full sibling index of STRs in autochromosome, which were also supported by the detection of 1-2 same alleles at each locus on X-chromosome.
  
  
  CONCLUSIONS
  In identification of full sibling sister, not only STRs on autochromosome but also polymorphism genetic markers in X-chromosome can be utilized.
authors: Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China. zsh-daisy@163.com
authors: Su-Hua
authors: SH
authors: Zhang
authors: Shu-Min
authors: SM
authors: Zhao
authors: Li
authors: L
authors: Li
mesh_terms: D000465:Algorithms; D000483:Alleles; D041321:Chromosomes, Human, X / Q000235:genetics*; D004247:DNA / Q000097:blood; D005260:Female; D053803:Forensic Genetics / Q000379:methods; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D035781:Siblings; D020080:Tandem Repeat Sequences
chemical_list: D005819:Genetic Markers; D004247:DNA