B lymphoblastic lymphoma presenting as a tumor of the nasopharynx in an adult patient.
In adults, non-Hodgkin's lymphoma (NHL) is the second most common neoplasm found in the head and neck region after squamous cell carcinoma. Within this region, primary NHL of the nasopharynx is rare. We report the case of a 28-year-old male diagnosed with a B lymphoblastic lymphoma (CD20-; CD79a+; CD3-; CD10+; PAX5+, CyclinD1-; TdT+) of the nasopharynx extending to the deep and superficial structures of the right hemiface, to the skull base with an intracranial component and a small but detectable bone marrow involvement, who was started on chemotherapy with a complete response. To the best of our knowledge, this is the first case of a primary nasopharynx B-LBL in an adult patient with such aggressive regional spread to be reported in the literature.
Lopes da Silva
Rodrigo
R
Serviço de Hematologia, Hospital Santo António dos Capuchos, Alameda Santo António dos Capuchos, 1169-050 Lisbon, Portugal. ronolosi@gmail.com
Fernandes
Teresa
T
Lopes
Alexandra
A
Santos
Susana
S
Mafra
Manuela
M
Rodrigues
António Silva
AS
de Sousa
Aida Botelho
AB
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology*; D012074:Remission Induction