title: Heart-type fatty acid binding protein is an early marker of myocardial damage after radiofrequency catheter ablation.
abstract: OBJECTIVE
  Radiofrequency (RF) ablation of arrhythmias induces myocardial damage and release of biomarkers. This study aimed to assess the kinetics of heart-type fatty acid-binding protein (h-FABP), a cytosolic protein released after myocardial injury incurred by both atrial and ventricular RF ablation, compared to other markers of myocardial injury.
  
  
  METHODS
  h-FABP, cTnI, CK-MB(mass) and myoglobin were evaluated in 30 patients with atrial or ventricular tachyarrhythmias before, immediately after and at 3, 6 and 24h after the procedure.
  
  
  RESULTS
  h-FABP increased immediately after the procedure in all subjects (6.6 ± 1.2 μg/L vs 2.7 ± 0.3, p<0.001) but increased significantly only in ventricular ablations. The peak of h-FABP significantly correlates with the values of time for mean power of RF application in both the entire patient cohort and in ventricular ablations.
  
  
  CONCLUSIONS
  h-FABP may be an early parameter for monitoring RF-induced lesions and the site of ablation was relevant for biomarker increase.
authors: CNR Institute of Clinical Physiology and Fondazione Toscana G. Monasterio, Pisa, Italy. danielag@ifc.cnr.it
authors: Daniela
authors: D
authors: Giannessi
authors: Marcello
authors: M
authors: Piacenti
authors: Maristella
authors: M
authors: Maltinti
authors: Andrea
authors: A
authors: Rossi
authors: Pietro
authors: P
authors: Di Cecco
authors: Umberto
authors: U
authors: Startari
authors: Manuela
authors: M
authors: Cabiati
authors: Luca
authors: L
authors: Panchetti
authors: Silvia
authors: S
authors: Del Ry
authors: Maria-Aurora
authors: MA
authors: Morales
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D017115:Catheter Ablation / Q000009:adverse effects*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D012016:Reference Values; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins