Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC cohort.
BACKGROUND
A considerable local variability in the rate of bronchopulmonary dysplasia (BPD) has been recorded previously.


OBJECTIVE
The objectives of the present study were to describe regional differences in the rate of BPD in very preterm neonates from a European population-based cohort and to further delineate risk factors.


METHODS
4,185 survivors to 36 weeks' postmenstrual age of 4,984 live-born infants born at 24+0-31+6 weeks' gestation in 2003 (the MOSAIC cohort) in 10 European regions were enrolled using predefined structured questionnaires.


RESULTS
Overall median gestational age of preterms without BPD was 30 weeks (range 23-31), median birth weight 1,320 g (range 490-3,150) compared with 27 weeks (23-31) and 900 g (370-2,460) in those with BPD. The region-specific crude rate of BPD ranged from 10.2% (Italian region) to 24.8% (UK Northern region). Maternal hypertension, immaturity, male gender, small for gestational age, Apgar <7 and region of care were associated with an increased incidence of BPD on multivariate analysis.


CONCLUSIONS
A wide variability of BPD between European regions may be explained by different local practices; the strongest association however was with degree of immaturity.
Gortner
Ludwig
L
Pediatric University Hospital, University of Saarland, Homburg, Germany. kilgor@uks.eu
Misselwitz
Björn
B
Milligan
David
D
Zeitlin
Jennifer
J
Kollée
Louis
L
Boerch
Klaus
K
Agostino
Rocco
R
Van Reempts
Patrick
P
Chabernaud
Jean-Louis
JL
Bréart
Gérard
G
Papiernik
Emile
E
Jarreau
Pierre-Henri
PH
Carrapato
Manuel
M
Gadzinowski
Janusz
J
Draper
Elizabeth
E
D001034:Apgar Score; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D015999:Multivariate Analysis; D011247:Pregnancy; D011446:Prospective Studies; D012044:Regression Analysis