NDR proteins: lessons learned from Arabidopsis and animal cells prompt a testable hypothesis.
N-myc Down Regulated (NDR) genes were discovered more than fifteen years ago. Indirect evidence support a role in tumor progression and cellular differentiation, but their biochemical function is still unknown. Our detailed analyses on Arabidopsis NDL proteins show their involvement in altering auxin transport, local auxin gradients and expression level of auxin transport proteins. Animal NDL proteins may be involved in membrane recycling of E-cadherin and effector for the small GTPase. In light of these findings, we hypothesize that NDL proteins regulate vesicular trafficking of auxin transport facilitator PIN proteins by biochemically alterating the local lipid environment of PIN proteins.
Mudgil
Yashwanti
Y
Department of Botany, University of Delhi, Delhi, India.
Jones
Alan M
AM
D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D015820:Cadherins / Q000378:metabolism*; D015536:Down-Regulation; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism
D029681:Arabidopsis Proteins; D015820:Cadherins; D007210:Indoleacetic Acids; D047908:Intracellular Signaling Peptides and Proteins; D026901:Membrane Transport Proteins