[Biosurgical débridement using Lucilia sericata-maggots - an update].
During the last years an increasing number of patients suffering from therapy refractory chronic wounds which are frequently infected by multi-resistant bacteria - e.g. methicillin-resistant Staphylococcus aureus - have led to an increasing interest in the treatment using larvae or maggots of the blow fly species Lucilia sericata. Maggots are responsible for necrectomy and they have antimicrobial activity in particular against grampositive bacteria like a disinfectant of the wound. It is concluded that maggots debridement therapy (MDT) using larvae of the species Lucilia sericata in non-healing chronic ulcers of the lower legs successfully leads to cleaning, debridement, reduced bacterial load, and improved wound granulation. A review is given on the clinical use of maggots, their mechanism of action and clinical efficacy for wound healing.
Nenoff
Pietro
P
Laboratorium für Medizinische Mikrobiologie, Mölbis, Germany. nenoff@mykologie-experten.de
Herrmann
Antonia
A
Gerlach
Christina
C
Herrmann
Jürgen
J
Simon
Jan Christoph
JC
D000818:Animals; D000075202:Contraindications; D003646:Debridement / Q000379:methods*; D006801:Humans; D007814:Larva; D009117:Muscidae; D011552:Pseudomonas Infections / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity; D014647:Varicose Ulcer / Q000628:therapy; D014774:Virulence; D014945:Wound Healing / Q000502:physiology; D014946:Wound Infection / Q000628:therapy; D014947:Wounds and Injuries / Q000628:therapy*