Targeted laryngeal photodynamic therapy with a balloon diffusing light source.
Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity.
Grossman
Craig
C
Department of Radiation Oncology, University of Pennsylvania, PA, USA.
Zhu
Timothy
T
Finlay
Jarod
J
Dimofte
Andrea
A
Malloy
Kelly
K
O'Malley
Bert
B
Weinstein
Gregory
G
Busch
Theresa M
TM
Quon
Harry
H
D000368:Aged; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D002404:Catheterization; D020701:Esophagoscopes; D005931:Glottis; D006801:Humans; D007818:Laryngeal Diseases / Q000188:drug therapy*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid