Functional neuroimaging in the postictal state.
The postictal state is defined as manifestation of seizure-induced reversible alterations in neuronal function, but not structure. Following a seizure, it is common to experience feelings of exhaustion, both mental and physical, that can last a day or two. There are three major hypotheses regarding what cellular and molecular mechanisms could cause the observed postictal symptoms: neurotransmitter depletion or changes in receptor concentration, active inhibition, and cerebral blood flow changes. Here, we describe the contributions of functional neuroimaging studies to the understanding of postictal symptoms.
Koepp
Matthias J
MJ
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK. mkoepp@ion.ucl.ac.uk
Diehl
Beate
B
Woermann
Friedrich G
FG
D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D012640:Seizures / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon