title: [Delayed hepatic resection for synchronous liver metastases from colorectal cancer].
abstract: BACKGROUND
  This study aimed to compare the surgical outcome and long-term survival between simultaneous and delayed resection of liver metastases from colorectal cancer (LM).
  
  
  METHODS
  Seventy-four patients with LM were divided into two groups, i. e., 32 patients who underwent hepatectomy at the time of colorectal surgery (simultaneous group) and 35 patients who underwent delayed liver resection (delayed group).
  
  
  RESULTS
  In 12 of the 35 (34%) patients from the delayed group, new metastatic lesions were found in the same and/or different segments after re-evaluation during the interval between operations. These patients had a shorter interval between procedures, and larger tumors than patients without tumor progression. There were significant differences (p=0.0454 and 0.0077) of hepatic disease-free survival between the metachronous or delayed groups and the simultaneous group. Multivariate analysis showed that simultaneous resection was one of three independent prognostic indicators with an influence on hepatic disease-free survival.
  
  
  CONCLUSIONS
  Tumor progression could be recognized and occult metastases were detected during the interval between operations. Delayed resection of synchronous LM may be useful to reduce the risk of rapid recurrence in the remnant liver.
authors: Dept. of Surgery, Hirakata Hospital, Kansai Medical University.
authors: Masaki
authors: M
authors: Kaibori
authors: Shigeyoshi
authors: S
authors: Iwamoto
authors: Morihiko
authors: M
authors: Ishizaki
authors: Kosuke
authors: K
authors: Matsui
authors: Yoshinori
authors: Y
authors: Hamada
authors: Kazuhiko
authors: K
authors: Yoshioka
authors: A-Hon
authors: AH
authors: Kwon
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate