title: A new approach in virtopsy: Postmortem ventilation in multislice computed tomography.
abstract: Although postmortem imaging has gained prominence in the field of forensic medicine, evaluation of the postmortem lung remains problematic. Specifically, differentiation of normal postmortem changes and pathological pulmonary changes is challenging and at times impossible. In this study, five corpses were ventilated using a mechanical ventilator with a pressure of 40 mbar (40.8 cm H(2)O). The ventilation was performed via an endotracheal tube, a larynx mask or a continuous positive airway pressure mask. Postmortem computed tomographic images of the lungs before and with a ventilation of 40 mbar (40.8 cm H(2)O) were evaluated and the lung volumes were measured with segmentation software. Postmortem ventilation led to a clearly visible decrease of both the density in the dependant parts of the lungs and ground glass attenuation, whereas consolidated areas remained unchanged. Furthermore, a mean increase in the lung volume of 2.10 l was seen. Pathological changes such as septal thickening or pulmonary nodules in the lung parenchyma became more detectable with postmortem ventilation. Intracorporal postmortem mechanical ventilation of the lungs appears to be an effective method for enhancing detection of small pathologies of the lung parenchyma as well as for discriminating between consolidation, ground glass attenuation and position-dependent density.
authors: Institute of Forensic Medicine, Center of Forensic Imaging and Virtopsy, University of Berne, Berne, Switzerland. tanja.germerott@irm.unibe.ch
authors: Tanja
authors: T
authors: Germerott
authors: Ulrich S
authors: US
authors: Preiss
authors: Lars C
authors: LC
authors: Ebert
authors: Thomas D
authors: TD
authors: Ruder
authors: Steffen
authors: S
authors: Ross
authors: Patricia M
authors: PM
authors: Flach
authors: Garyfalia
authors: G
authors: Ampanozi
authors: Laura
authors: L
authors: Filograna
authors: Michael J
authors: MJ
authors: Thali
mesh_terms: D000328:Adult; D000368:Aged; D001344:Autopsy / Q000379:methods*; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*