title: Cartilage intermediate layer protein gene is associated with lumbar disc degeneration in male, but not female, collegiate athletes.
abstract: BACKGROUND
  The authors previously identified a significant association between lumbar disc degeneration (LDDG) and cartilage intermediate layer protein (CILP) single nucleotide polymorphism (SNP) in collegiate male judokas.
  
  
  OBJECTIVE
  A significant association between LDDG and the CILP SNP is observed in Japanese collegiate athletes.
  
  
  METHODS
  Cross-sectional study; Level of evidence, 3.
  
  
  METHODS
  The participants were 601 trained collegiate athletes (male, 403; female, 198) from 7 different sports. Lumbar disc degeneration was evaluated using T2-weighted magnetic resonance imaging. Genotyping of the CILP gene (1184T/C) was performed by using DNA sequencing.
  
  
  RESULTS
  Among the 601 collegiate athletes, the odds ratio (OR) for the occurrence of LDDG with the CILP C allele was 1.4 (95% confidence interval [CI], 1.05-1.86). By using logistic regression analysis concomitant with the interaction term and the Wald test, the authors found that weight (OR, 1.04; 95% CI, 1.02-1.06), CILP genotype (CT: OR, 2.0; 95% CI, 1.24-3.15; CC: OR, 2.9; 95% CI, 1.09-7.74), and gender (OR, 2.1; 95% CI, 1.21-3.67) were significant risk factors for LDDG. These analyses also indicated that there was no effect of the CILP genotype on LDDG in female athletes.
  
  
  CONCLUSIONS
  The CILP SNP 1184T/C is a risk factor for male collegiate athletes. Information regarding the CILP gene polymorphism may be important for preventing and managing lumbar disc diseases, especially in male athletes.
authors: Nippon Sport Science University, Tokyo, Japan.
authors: Seok-Ki
authors: SK
authors: Min
authors: Koichi
authors: K
authors: Nakazato
authors: Yosuke
authors: Y
authors: Yamamoto
authors: Koji
authors: K
authors: Gushiken
authors: Hideo
authors: H
authors: Fujimoto
authors: Hitone
authors: H
authors: Fujishiro
authors: Yuri
authors: Y
authors: Kobayakawa
authors: Kenji
authors: K
authors: Hiranuma
mesh_terms: D000704:Analysis of Variance; D001265:Athletic Injuries / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D015992:Body Mass Index; D002357:Cartilage Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011755:Pyrophosphatases / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
chemical_list: D016326:Extracellular Matrix Proteins; C114607:CILP protein, human; D011755:Pyrophosphatases