Sleep in psychiatric disorders: where are we now?
Although the precise function of sleep is unknown, decades of research strongly implicate that sleep has a vital role in central nervous system (CNS) restoration, memory consolidation, and affect regulation. Slow-wave sleep (SWS) and rapid eye movement (REM) sleep have been of significant interest to psychiatrists; SWS because of its putative role in CNS energy recuperation and cognitive function, and REM sleep because of its suggested involvement in memory, mood regulation, and possible emotional adaptation. With the advent of the polysomnogram, researchers are now beginning to understand some of the consequences of disrupted sleep and sleep deprivation in psychiatric disorders. The same neurochemistry that controls the sleep-wake cycle has also been implicated in the pathophysiology of numerous psychiatric disorders. Thus it is no surprise that several psychiatric disorders have prominent sleep symptoms. This review will summarize normal sleep architecture, and then examine sleep abnormalities and comorbid sleep disorders seen in schizophrenia, as well as anxiety, cognitive, and substance abuse disorders.
Kyung Lee
Elliott
E
Faculty of Medicine, University of Ottawa, Department of Psychiatry and Psychology, Ottawa, Ontario, Canada. elliott.lee@rohcg.on.ca
Douglass
Alan B
AB
D000368:Aged; D019973:Alcohol-Related Disorders / Q000150:complications / Q000503:physiopathology; D058633:Antipyretics; D001008:Anxiety Disorders / Q000150:complications / Q000503:physiopathology; D003704:Dementia / Q000150:complications / Q000503:physiopathology; D006801:Humans; D002189:Marijuana Abuse / Q000150:complications / Q000503:physiopathology; D001523:Mental Disorders / Q000150:complications / Q000503:physiopathology*; D017286:Polysomnography; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology; D019966:Substance-Related Disorders / Q000150:complications / Q000503:physiopathology
D058633:Antipyretics