title: Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers.
abstract: The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported. The cognitive and psychomotor evaluation consisted of several computerized and paper-and-pencil measures. Eslicarbazepine acetate and oxcarbazepine had similar overall cognitive profiles and did not cause clinically relevant cognitive impairment. The incidence of adverse events was lower with eslicarbazepine acetate than with oxcarbazepine.
authors: Kendle Early Stage, Toronto, ON, Canada.
authors: Denise
authors: D
authors: Milovan
authors: Luis
authors: L
authors: Almeida
authors: Myroslava K
authors: MK
authors: Romach
authors: Teresa
authors: T
authors: Nunes
authors: José Francisco
authors: JF
authors: Rocha
authors: Marta
authors: M
authors: Sokowloska
authors: Edward M
authors: EM
authors: Sellers
authors: Patrício
authors: P
authors: Soares-da-Silva
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007858:Learning / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D000078330:Oxcarbazepine; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D003984:Dibenzazepines; D002220:Carbamazepine; C416835:eslicarbazepine acetate; D000078330:Oxcarbazepine