title: Imaging of brain tumors: perfusion/permeability.
abstract: The use of biomarkers of microvascular structure and function from perfusion and permeability imaging is now well established in neuro-oncological research. There remain significant challenges to be overcome before these techniques and related biomarkers can find general clinical acceptance. Core to this is the standardization of acquisition and processing protocols for robust use across multiple clinical sites. The potential clinical benefits of these approaches are already becoming clear, particularly in the setting of novel antiangiogenic therapies. With an increasing body of evidence in the scientific literature, and with a steadily falling barrier to entry, the coming decade should see rapid developments in imaging biomarkers, and facilitate their transition into routine clinical practice.
authors: School of Cancer and Imaging Sciences, Wolfson Molecular Imaging Centre, The University of Manchester, 27 Palatine Road, Manchester, England M20 3LJ, UK. gerard.thompson@manchester.ac.uk
authors: Gerard
authors: G
authors: Thompson
authors: Samantha Jane
authors: SJ
authors: Mills
authors: Stavros Michael
authors: SM
authors: Stivaros
authors: Alan
authors: A
authors: Jackson
mesh_terms: D014408:Biomarkers, Tumor; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D002199:Capillary Permeability; D003287:Contrast Media; D003937:Diagnosis, Differential; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D009389:Neovascularization, Pathologic; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media