title: A Case of Xanthoma Disseminatum Accentuating over the Eyelids.
abstract: Xanthoma disseminatum (XD) is a rare, benign non-familial mucocutaneous disorder, which is a subset of non-Langerhans cell histiocytosis. It is characterized by mucocutaneous xanthomas in a disseminated form typically involving the eyelids, trunk, face, and proximal extremities and occurs in flexures and folds such as axillae and the groin. Mucosal involvement of the respiratory or gastrointestinal tracts may lead to hoarseness or intestinal obstruction from a mechanical mass effect. This paper outlines the case of a 47-year-old female with progressive yellow-to-brown confluent nodules and plaques of various sizes on her scalp, face, oral mucosa, neck, shoulder, axillary folds, and perianal area. Xanthomas accentuating over the eyelids and eyelashes led to partial obstruction of her visual field and interfered with blinking. Further, she suffered from xerophthalmia. The presentation of histopathological features including foamy histiocytes, inflammatory cells, and Touton giant cells in conjunction with her clinical findings indicated a diagnosis of XD. Evaluations for extracutaneous involvement including the central nervous system, respiratory tract, gastrointestinal tract, and bone resulted in nonspecific findings. Although she has been treated with surgical excisions, CO(2) laser therapy, and oral prednisolone, new lesions are still emerging.
authors: Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Jun Young
authors: JY
authors: Kim
authors: Hong Dae
authors: HD
authors: Jung
authors: Yoon Seok
authors: YS
authors: Choe
authors: Weon Ju
authors: WJ
authors: Lee
authors: Seok-Jong
authors: SJ
authors: Lee
authors: Do Won
authors: DW
authors: Kim
authors: Byung Soo
authors: BS
authors: Kim