title: High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory.
abstract: Drug addiction is a chronic brain disorder, characterized by the loss of the ability to control drug consumption. The neurobiology of addiction is traditionally thought to involve the mesocorticolimbic system of the brain. However, the hippocampus has received renewed interest for its potential role in addiction. Part of this attention is because of the fact that drugs of abuse are potent negative regulators of neurogenesis in the adult hippocampus and may as a result impair learning and memory. We investigated the effects of different dosages of contingent cocaine on cell proliferation and neurogenesis in the dentate gyrus of the hippocampus and on working memory during abstinence, using the water T-maze test, in adult rats. We found that cocaine, in addition to the changes it produces in the reward system, if taken in high doses, can attenuate the production and development of new neurons in the hippocampus, and reduce working memory.
authors: Neuropharmacology Laboratory, The Mina & Everard Goodman Faculty of Life Sciences, Israel.
authors: Einav
authors: E
authors: Sudai
authors: Ofri
authors: O
authors: Croitoru
authors: Alona
authors: A
authors: Shaldubina
authors: Lital
authors: L
authors: Abraham
authors: Iris
authors: I
authors: Gispan
authors: Yakov
authors: Y
authors: Flaumenhaft
authors: Ilana
authors: I
authors: Roth-Deri
authors: Noa
authors: N
authors: Kinor
authors: Shai
authors: S
authors: Aharoni
authors: Moshe
authors: M
authors: Ben-Tzion
authors: Gal
authors: G
authors: Yadid
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000503:physiopathology* / Q000523:psychology; D018891:Dentate Gyrus / Q000187:drug effects* / Q000503:physiopathology; D018765:Dopamine Uptake Inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
chemical_list: D000697:Central Nervous System Stimulants; D018765:Dopamine Uptake Inhibitors; D003042:Cocaine