title: A dietary tomato supplement prevents prostate cancer in TRAMP mice.
abstract: Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive prostate cancer that mirrors the stages of the human form. In this study, the effects of a diet enriched with processed whole tomatoes on survival, tumorigenesis, and progression of prostate cancer, and the antioxidant and inflammatory status of TRAMP mice were investigated. Tomato diet significantly increased overall survival (P < 0.01), delayed progression from prostatic intraepithelial neoplasia to adenocarcinoma, and decreased the incidence of poorly differentiated carcinoma. Biochemical data disclosed an increase in serum antioxidant activity and a reduction of serum inflammation/angiogenesis biomarkers of particular importance in prostate carcinogenesis.
authors: Department of Oncology and Neurosciences, G. d'Annunzio University, Chieti, Italy.
authors: Tania
authors: T
authors: Pannellini
authors: Manuela
authors: M
authors: Iezzi
authors: Marcella
authors: M
authors: Liberatore
authors: Federica
authors: F
authors: Sabatini
authors: Stefano
authors: S
authors: Iacobelli
authors: Cosmo
authors: C
authors: Rossi
authors: Saverio
authors: S
authors: Alberti
authors: Carmine
authors: C
authors: Di Ilio
authors: Paola
authors: P
authors: Vitaglione
authors: Vincenzo
authors: V
authors: Fogliano
authors: Mauro
authors: M
authors: Piantelli
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood; D004032:Diet; D019587:Dietary Supplements; D018450:Disease Progression; D007150:Immunohistochemistry; D018551:Solanum lycopersicum; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008517:Phytotherapy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor