Chemokines: sirens of neutrophil recruitment-but is it just one song?
Neutrophil trafficking to inflamed tissues requires the integration of multiple chemoattractant guidance signals. In this issue of Immunity, Chou et al. (2010) demonstrate that collaborative "cascades" of chemoattractant mediators control neutrophil recruitment to arthritic joints in mice.
McDonald
Braedon
B
Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Kubes
Paul
P