title: Complete androgen insensitivity syndrome: an anatomic evaluation and sexual function questionnaire pilot study.
abstract: OBJECTIVE
  To further characterize the anatomy and sexual function of women with CAIS compared to normal females, and assess the utility of magnetic resonance imaging (MRI) to distinguish anatomical differences.
  
  
  METHODS
  In a prospective cohort pilot study, five individuals with androgen insensitivity syndrome and six, normal, nulliparous women underwent an interview, physical examination, questionnaire completion and MRI of the pelvis. Statistical analysis was performed with emphasis on determining significant differences in anatomical findings and sexual satisfaction.
  
  
  RESULTS
  MRI demonstrated statistically significant differences in vaginal depth and size that were not confirmed on physical exam. MRI and physical exam demonstrated a non-significant difference in average phallic thickness between the two groups, although the CAIS group clitoral width tended to be smaller. Physical exam demonstrated a higher average erect height and longer arm span in the CAIS patients but this was not statistically significant. No significant differences were noted in categories designed to assess satisfaction with ability to achieve orgasm, vaginal appearance and frequency of sexual intercourse between the two groups.
  
  
  CONCLUSIONS
  The women with CAIS were as satisfied with sexual function as were the women within the control group. Physical exam and MRI did not find any statistically significant clinically relevant differences between the two groups.
authors: Urology, UCSF, San Francisco, CA 94143-0738, USA. jmwilson@salud.unm.edu
authors: Jason M
authors: JM
authors: Wilson
authors: Anne
authors: A
authors: Arnhym
authors: Angie
authors: A
authors: Champeau
authors: Michele
authors: M
authors: Ebbers
authors: Fergus
authors: F
authors: Coakley
authors: Laurence
authors: L
authors: Baskin
mesh_terms: D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000473:pathology* / Q000503:physiopathology*; D002987:Clitoris / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000473:pathology; D010413:Penis / Q000473:pathology; D010641:Phenotype; D010865:Pilot Projects; D011446:Prospective Studies; D015203:Reproducibility of Results; D019529:Sexuality / Q000502:physiology*; D011795:Surveys and Questionnaires / Q000592:standards*; D014521:Urethra / Q000473:pathology; D014621:Vagina / Q000473:pathology; D055815:Young Adult