title: Structural features of phenoxycarbonylimino neonicotinoids acting at the insect nicotinic receptor.
abstract: Substituted-phenoxycarbonylimino neonicotinoid ligands with an electron-donating group showed significantly higher affinity to the insect nicotinic receptor relative to that of the analogue with an electron-withdrawing substituent, thereby establishing in silico binding site interaction model featuring that the phenoxy ring of neonicotinoids and the receptor loop D tryptophan indole plane form a face-to-edge aromatic interaction.
authors: The United Graduate School of Agricultural Science, Gifu University, Gifu 501-1193, Japan.
authors: Ikuya
authors: I
authors: Ohno
authors: Motohiro
authors: M
authors: Tomizawa
authors: Nozomi
authors: N
authors: Miyazu
authors: Gohito
authors: G
authors: Kushibiki
authors: Kumiko
authors: K
authors: Noda
authors: Yasunori
authors: Y
authors: Hasebe
authors: Kathleen A
authors: KA
authors: Durkin
authors: Taiji
authors: T
authors: Miyake
authors: Shinzo
authors: S
authors: Kagabu
mesh_terms: D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D007093:Imidazoles / Q000737:chemistry*; D019476:Insect Proteins / Q000737:chemistry* / Q000378:metabolism; D007313:Insecta; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; D019476:Insect Proteins; D007306:Insecticides; D008024:Ligands; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011725:Pyridines; D011978:Receptors, Nicotinic; C082359:imidacloprid; C023666:pyridine