title: Epithelial-myoepithelial carcinoma with myoepithelial anaplasia: report of a case with cytologic findings of a rare variant.
abstract: BACKGROUND
  Epithelial-myoepithelial carcinoma (EMC) is usually a low grade malignancy with rare mortality. Rare aggressive variants of EMC, dedifferentiated EMC and EMC with myoepithelial anaplasia have been reported.
  
  
  METHODS
  An 81-year-old man presented with EMC of the parotid gland showing the classical type at the time of initial presentation and a high grade type with myoepithelial anaplasia at recurrence after 10 years. We compared the histologic and cytologic findings of the initial and recurrent tumors. Aspiration cytology of the initial tumor was typical of classical EMC, represented by a biphasic pattern composed of sheetlike and tubular clusters. In contrast, cytologic specimens of the recurrent tumor, which had a focally biphasic pattern similar to that of the initial tumor, also had many isolated or discohesive piled-up clusters of spindle and polygonal cells with nuclear atypia.
  
  
  CONCLUSIONS
  The cytologic findings of the recurrent tumor were consistent with a rare variant of EMC with myoepithelial anaplasia. To the best of our knowledge, this is the first report of the cytologic finding of an EMC with myoepithelial anaplasia.
authors: Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.
authors: Takashi
authors: T
authors: Suzuki
authors: Shin-ichi
authors: S
authors: Murata
authors: Hiroshi
authors: H
authors: Yamaguchi
authors: Yoshihiko
authors: Y
authors: Shimizu
authors: Michio
authors: M
authors: Shimizu
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001707:Biopsy, Needle; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018396:Mucin-1 / Q000378:metabolism; D009208:Myoepithelioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1