title: Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain.
abstract: We report a multicity outbreak of cfr-containing linezolid-resistant Staphylococcus epidermidis in Ohio. Thirty-nine isolates were obtained from 2 hospitals. Two clones with different mechanisms of linezolid resistance were circulating in hospital A. One of these contained the cfr gene, and the other a ribosomal mutation. The clone containing cfr was identical in both hospitals.
authors: Summa Health System, Akron, Ohio, USA.
authors: Hector
authors: H
authors: Bonilla
authors: Michael D
authors: MD
authors: Huband
authors: Joan
authors: J
authors: Seidel
authors: Helen
authors: H
authors: Schmidt
authors: Marykay
authors: M
authors: Lescoe
authors: Sandra P
authors: SP
authors: McCurdy
authors: M Megan
authors: MM
authors: Lemmon
authors: Lori A
authors: LA
authors: Brennan
authors: A
authors: A
authors: Tait-Kamradt
authors: Laura
authors: L
authors: Puzniak
authors: John P
authors: JP
authors: Quinn
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006761:Hospitals; D006801:Humans; D000069349:Linezolid; D009820:Ohio / Q000453:epidemiology; D023303:Oxazolidinones / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C539943:CFR protein, Staphylococcus aureus; D004269:DNA, Bacterial; D023303:Oxazolidinones; D000069349:Linezolid