title: Impaired response inhibition in ill Gulf War veterans.
abstract: Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.
authors: School of Behavioral and Brain Sciences, Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
authors: Gail D
authors: GD
authors: Tillman
authors: Timothy A
authors: TA
authors: Green
authors: Thomas C
authors: TC
authors: Ferree
authors: Clifford S
authors: CS
authors: Calley
authors: Mandy J
authors: MJ
authors: Maguire
authors: Richard
authors: R
authors: Briggs
authors: John
authors: J
authors: Hart
authors: Robert W
authors: RW
authors: Haley
authors: Michael A
authors: MA
authors: Kraut
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D001526:Behavioral Symptoms / Q000209:etiology*; D016022:Case-Control Studies; D002755:Choice Behavior / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D047830:Gulf War; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D018923:Persian Gulf Syndrome / Q000150:complications* / Q000523:psychology*; D011930:Reaction Time / Q000502:physiology; D014728:Veterans