title: Prostate cancer: 1.5 T endo-coil dynamic contrast-enhanced MRI and MR spectroscopy--correlation with prostate biopsy and prostatectomy histopathological data.
abstract: OBJECTIVE
  To investigate diagnostic accuracy of detection of prostate cancer by magnetic resonance: to evaluate the performance of T2WI, DCEMRI and CSI and to correlate the results with biopsy and radical prostatectomy histopathological data.
  
  
  METHODS
  43 patients, scheduled for radical prostatectomy, underwent prostate MR examination. Prostate cancer was identified by transrectal ultrasonographically (TRUS) guided sextant biopsy. MR examination was performed at 1.5 T with an endorectal MR coil. Cancer localisation was performed on sextant-basis--for comparison between TRUS biopsy, MR techniques and histopathological findings on prostatectomy specimens.
  
  
  RESULTS
  Prostate cancer was identified in all 43 patients by combination of the three MR techniques. The detection of prostate cancer on sextant-basis showed sensitivity and specificity: 50% and 91% for TRUS, 72% and 55% for T2WI, 49% and 69% for DCEMRI, and 46% and 78% for CSI.
  
  
  CONCLUSIONS
  T2WI, DCEMRI and CSI in combination can identify prostate cancer. Further development of MR technologies for these MR methods is necessary to improve the detection of the prostate cancer.
authors: Department of Diagnostic Radiology, Copenhagen University Hospital at Herlev, Denmark. elcha@heh.regionh.dk
authors: Elizaveta
authors: E
authors: Chabanova
authors: Ingegerd
authors: I
authors: Balslev
authors: Vibeke
authors: V
authors: Logager
authors: Alastair
authors: A
authors: Hansen
authors: Henrik
authors: H
authors: Jakobsen
authors: Bjarne
authors: B
authors: Kromann-Andersen
authors: Nis
authors: N
authors: Norgaard
authors: Thomas
authors: T
authors: Horn
authors: Henrik S
authors: HS
authors: Thomsen
mesh_terms: D000368:Aged; D001706:Biopsy; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014463:Ultrasonography
chemical_list: D003287:Contrast Media