title: Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.
abstract: Potent and selective adenosine A(1) receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed.
authors: Bayer Schering Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Building 460, D-42096 Wuppertal, Germany. nils.griebenow@bayerhealthcare.com
authors: Nils
authors: N
authors: Griebenow
authors: Lars
authors: L
authors: Bärfacker
authors: Heinrich
authors: H
authors: Meier
authors: Dirk
authors: D
authors: Schneider
authors: Nicole
authors: N
authors: Teusch
authors: Klemens
authors: K
authors: Lustig
authors: Raimund
authors: R
authors: Kast
authors: Peter
authors: P
authors: Kolkhof
mesh_terms: D058916:Adenosine A1 Receptor Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D043682:Receptor, Adenosine A1 / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D058916:Adenosine A1 Receptor Antagonists; D011720:Pyrazoles; D043682:Receptor, Adenosine A1