title: Association of metabolic syndrome and IgA nephropathy.
abstract: BACKGROUND
  The disorders associated with metabolic syndrome (MS) can lead to renal disease. IgA nephropathy is the most common form of glomerulonephritis, and many patients with this disorder progress to renal failure.
  
  
  OBJECTIVE
  To identify the effect of MS on IgA nephropathy by retrospectively comparing patients who had IgA nephropathy and MS with those who had IgA nephropathy alone.
  
  
  METHODS
  30 patients with MS and IgA nephropathy (MS group), and 30 matched controls with IgA nephropathy alone (non-MS group) were enrolled. IgA nephropathy was diagnosed by renal biopsy; activity and severity was graded by two classification systems. MS was diagnosed by criteria of the Diabetes Society of the Chinese Medical Association.
  
  
  RESULTS
  Simple and multiple linear regression models (which adjusted for age, gender and body surface area) showed that only hypertension significantly affected serum creatinine, an indicator of the clinical severity of renal disease. Simple and multiple linear regression models (which adjusted for age, gender and body surface area) also showed that hypertensive patients had higher Katafuchi scores, an indicator of the pathological severity of renal disease.
  
  
  CONCLUSIONS
  Among the disorders associated with MS, hypertension is the most important factor for renal disease.
authors: Division of Nephrology, Fuzhou Dongfang Hospital, People's Republic of China. wanglp306@126.com
authors: Liping
authors: L
authors: Wang
authors: Yong
authors: Y
authors: Zhang
authors: Shanyuan
authors: S
authors: Chen
authors: Jian
authors: J
authors: Chen
authors: Yongze
authors: Y
authors: Zhuang
authors: Jinhua
authors: J
authors: Chen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D004812:Epidemiologic Methods; D005260:Female; D005919:Glomerular Filtration Rate; D005922:Glomerulonephritis, IGA / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D003404:Creatinine