title: Registration of 3-dimensional facial photographs for clinical use.
abstract: OBJECTIVE
  To objectively evaluate treatment outcomes in oral and maxillofacial surgery, pre- and post-treatment 3-dimensional (3D) photographs of the patient's face can be registered. For clinical use, it is of great importance that this registration process is accurate (< 1 mm). The purpose of this study was to determine the accuracy of different registration procedures.
  
  
  METHODS
  Fifteen volunteers (7 males, 8 females; mean age, 23.6 years; range, 21 to 26 years) were invited to participate in this study. Three-dimensional photographs were captured at 3 different times: baseline (T(0)), after 1 minute (T(1)), and 3 weeks later (T(2)). Furthermore, a 3D photograph of the volunteer laughing (T(L)) was acquired to investigate the effect of facial expression. Two different registration methods were used to register the photographs acquired at all different times: surface-based registration and reference-based registration. Within the surface-based registration, 2 different software packages (Maxilim [Medicim NV, Mechelen, Belgium] and 3dMD Patient [3dMD LLC, Atlanta, GA]) were used to register the 3D photographs acquired at the various times. The surface-based registration process was repeated with the preprocessed photographs. Reference-based registration (Maxilim) was performed twice by 2 observers investigating the inter- and intraobserver error.
  
  
  RESULTS
  The mean registration errors are small for the 3D photographs at rest (0.39 mm for T(0)-T(1) and 0.52 mm for T(0)-T(2)). The mean registration error increased to 1.2 mm for the registration between the 3D photographs acquired at T(0) and T(L). The mean registration error for the reference-based method was 1.0 mm for T(0)-T(1), 1.1 mm for T(0)-T(2), and 1.5 mm for T(0) and T(L). The mean registration errors for the preprocessed photographs were even smaller (0.30 mm for T(0)-T(1), 0.42 mm for T(0)-T(2), and 1.2 mm for T(0) and T(L)). Furthermore, a strong correlation between the results of both software packages used for surface-based registration was found. The intra- and interobserver error for the reference-based registration method was found to be 1.2 and 1.0 mm, respectively.
  
  
  CONCLUSIONS
  Surface-based registration is an accurate method to compare 3D photographs of the same individual at different times. When performing the registration procedure with the preprocessed photographs, the registration error decreases. No significant difference could be found between both software packages that were used to perform surface-based registration.
authors: Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, The Netherlands. t.maal@mka.umcn.nl
authors: Thomas J J
authors: TJ
authors: Maal
authors: Bram
authors: B
authors: van Loon
authors: Joanneke M
authors: JM
authors: Plooij
authors: Frits
authors: F
authors: Rangel
authors: Anke M
authors: AM
authors: Ettema
authors: Wilfred A
authors: WA
authors: Borstlap
authors: Stefaan J
authors: SJ
authors: Bergé
mesh_terms: D000328:Adult; D005145:Face / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D015588:Observer Variation; D019647:Oral Surgical Procedures; D017063:Outcome Assessment, Health Care / Q000379:methods; D010780:Photogrammetry / Q000379:methods*; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D012984:Software; D018709:Statistics, Nonparametric; D013382:Subtraction Technique; D055815:Young Adult