title: The impact of sickle cell trait on glycated haemoglobin in diabetes mellitus.
abstract: OBJECTIVE
  To determine the effect of sickle cell trait on measurement of glycated haemoglobin (HbA(1c)) in African American patients with diabetes mellitus.
  
  
  METHODS
  This is a retrospective study including 885 outpatients who underwent HbA(1c) testing. Medical record review and sickle cell trait determinations based on the HbA(1c) assay were performed in African American participants. The relationship between HbA(1c) and serum glucose measurements was analysed.
  
  
  RESULTS
  Data were obtained from 385 AA (109 with SCT, 22 with haemoglobin C trait and 254 without haemoglobinopathy) and 500 European American patients. In a model created through multivariate repeated-effects regression, the relationship between HbA(1c) and simultaneous serum glucose did not differ between African American subjects with and without the sickle cell trait, but differed between African American subjects without the sickle cell trait and European Americans (P = 0.0002).
  
  
  CONCLUSIONS
  Sickle cell trait does not impact the relationship between HbA(1c) and serum glucose concentration. In addition, it does not appear to account for ethnic difference in this relationship between African Americans and whites.
authors: Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. ableyer@wfubmc.edu
authors: A J
authors: AJ
authors: Bleyer
authors: S
authors: S
authors: Vidya
authors: L
authors: L
authors: Sujata
authors: G B
authors: GB
authors: Russell
authors: D
authors: D
authors: Akinnifesi
authors: D
authors: D
authors: Hire
authors: Z
authors: Z
authors: Shihabi
authors: M A
authors: MA
authors: Knovich
authors: P
authors: P
authors: Daeihagh
authors: J
authors: J
authors: Calles
authors: B I
authors: BI
authors: Freedman
mesh_terms: D001741:Black or African American; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000208:ethnology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012805:Sickle Cell Trait / Q000097:blood* / Q000208:ethnology; D044465:White People
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin