Clinical trials in brain tumor surgery.
The prognosis for patients diagnosed with primary central nervous system tumors, such as gliomas, remains generally poor. Improved treatment (standard therapies and novel strategies) is needed. Glioma surgery is a key part of standard treatment and has established roles in providing tissue for diagnosis and in tumor debulking. Several techniques to increase safe surgical resection have been investigated. In addition, novel surgical modalities introducing therapeutic agents locally are increasingly common. This article reviews recent glioma surgery clinical trials, focusing on outcome studies, novel surgical techniques, and local therapeutic agent delivery.
Hoover
Jason M
JM
Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Chang
Susan M
SM
Parney
Ian F
IF
D001707:Biopsy, Needle / Q000379:methods; D001918:Brachytherapy / Q000379:methods; D001921:Brain / Q000473:pathology / Q000601:surgery; D001931:Brain Mapping / Q000379:methods; D001932:Brain Neoplasms / Q000188:drug therapy / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000379:methods*; D005910:Glioma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D016343:Monitoring, Intraoperative / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods*; D013238:Stereotaxic Techniques