Synthesis of vinyl sulfides by copper-catalyzed decarboxylative C-S cross-coupling.
A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed. In the presence of CuI and Cs(2)CO(3), a variety of thiols reacted with arylpropiolic acids to afford the corresponding vinyl sulfides in good to excellent yields with high stereoselectivity for Z-isomers.
Ranjit
Sadananda
S
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Duan
Zhongyu
Z
Zhang
Pengfei
P
Liu
Xiaogang
X
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013440:Sulfides / Q000138:chemical synthesis*; D013455:Sulfur / Q000737:chemistry*; D014753:Vinyl Compounds / Q000138:chemical synthesis*
D013438:Sulfhydryl Compounds; D013440:Sulfides; D014753:Vinyl Compounds; D013455:Sulfur; D002244:Carbon; D003300:Copper