title: [Clinical features of hepatitis-associated aplastic anemia in children].
abstract: OBJECTIVE
  To study the clinical features of hepatitis-associated aplastic anemia (HAAA) in children.
  
  
  METHODS
  The clinical data of the children with newly diagnosed HAAA from January 2007 to December 2008 were respectively studied, including clinical manifestations, and blood routine, bone marrow examination, viral serology and immune function results as well as treatment and prognosis.
  
  
  RESULTS
  A total of 8 children were confirmed as HAAA, accounting for 4.9% in children with aplastic anemia. There were 7 males and 1 female. The median age was 7.5 years (range 4.4 to 10.3 years) at diagnosis. They had negative serologic results and the causes of hepatitis could not be identified. The median interval from hepatitis occurrence to blood cell reduction was 6 weeks. Three cases were diagnosed as severe aplastic anemia and 5 cases as very severe aplastic anemia. Severe T cell immune disorders were found in all 8 cases. The percentage of Ts cells increased and the percentage of Th cells decreased significantly in the 8 children with HAAA. Four children survived after immune suppress treatment, three children died within one month after diagnosis and one child required own discharge without treatment.
  
  
  CONCLUSIONS
  HAAA is more frequent in male school children. The children with HAAA have severe T cell immune disorders, with a higher early death rate. Immune suppress treatment is effective.
authors: Hematological/Oncological Center, Beijing Children's Hospital, Beijing 100045, China. duanyanlong@hotmail.com
authors: Yan-Long
authors: YL
authors: Duan
authors: Run-Hui
authors: RH
authors: Wu
authors: Shuang
authors: S
authors: Yang
authors: Rui
authors: R
authors: Zhang
authors: Li
authors: L
authors: Zhang
authors: Xuan
authors: X
authors: Zhou
authors: Jin
authors: J
authors: Jiang
authors: Mei
authors: M
authors: Jin
mesh_terms: D000741:Anemia, Aplastic / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D008297:Male; D011379:Prognosis