title: [Chemical constituents from Excoecaria acerifclia and their bioactivites].
abstract: OBJECTIVE
  To investigate the chemical constituents of Excoecaria acerifclia and their antitumor activities.
  
  
  METHODS
  The constituents were isolated and purified by column chromatography. Their structures were identified by their physicochemical properties and spectral features. Cytotoxicities of the purified compounds were evaluated by MTI method against human cancer cell lines HepG2.
  
  
  RESULTS
  Eight compounds were isolated and identified as: 7-hydroxy-6-methoxy-coumarin (1), 8-hydroxy-6,7-methoxy-coumarin (2), kaempferol (3), kaempferol-3-O-beta-D-glucoside (4), quercetin-3-O-beta-D galactoside (5), kaempferol-3-O-beta-D-glucoside-2"-gallate (6), beta-sitosterol (7), daucosterol (8).
  
  
  CONCLUSIONS
  All compounds were isolated from this plant for the first time. Compounds 5 showed inhibitory activity towards HepG2 with IC50 values of 7.13 mol x L(-1).
authors: Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Education, Anhui Agricultural University, Hefei 230036, China.
authors: Yunzhi
authors: Y
authors: Li
authors: Chao
authors: C
authors: Ma
authors: Jing
authors: J
authors: Huang
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D010936:Plant Extracts / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts