Action of nicotine and ovariectomy on bone regeneration after tooth extraction in rats.
OBJECTIVE
The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.


METHODS
For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on days 7 and 14 when the alveoli were removed for further analyses.


RESULTS
The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.


CONCLUSIONS
These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy.
Machado
Giscard José Ribeiro
GJ
Department of Basic Sciences, Dental School of Araçatuba, UNESP-University Estadual Paulista, São Paulo, Brazil.
Dias
Sheila Mônica Damásio
SM
Bosco
Alvaro Fancisco
AF
Okamoto
Tetuo
T
Bedran de Castro
João César
JC
Dornelles
Rita Cássia Menegati
RC
D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D003238:Connective Tissue / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D004967:Estrogens / Q000172:deficiency / Q000502:physiology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005881:Gingiva / Q000473:pathology; D007180:Incisor / Q000601:surgery; D007279:Injections, Subcutaneous; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008437:Maxilla / Q000601:surgery; D018919:Neovascularization, Physiologic / Q000502:physiology; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D010006:Osteoblasts / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology
D004967:Estrogens; D009538:Nicotine