title: Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma.
abstract: BACKGROUND
  Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous PON1 polymorphisms and the risk of developing astrocytoma and meningioma.
  
  
  METHODS
  Seventy one consecutive patients with brain tumors (43 with astrocytoma grade II/III and 28 with meningioma) with ages ranging 21 to 76 years, and 220 healthy controls subjects were analyzed for the frequency of the nonsynonymous PON1 genotypes L55M rs854560 and Q192R rs662. All participants were adult Caucasian individuals recruited in the central area of Spain.
  
  
  RESULTS
  The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls. The minor allele frequencies were as follows: PON1 55L, 0.398, 0.328 and 0.286 for patients with astrocytoma, meningioma and control individuals, respectively; PON1 192R, 0.341, 0.362 and 0.302 for patients with astrocytoma, meningioma and control individuals, respectively. Correction for age, gender, or education, made no difference in odds ratios and the p values remained non-significant. Haplotype association analyses did not identify any significant association with the risk of developing astrocytoma or meningioma.
  
  
  CONCLUSIONS
  Common nonsynonymous PON1 polymorphisms are not related with the risk of developing astrocytoma and meningioma.
authors: Department of Biochemistry and Molecular Biology and Genetics, University of Extremadura, Avda de Elvas s/n, 06071, Badajoz, Spain.
authors: Carmen
authors: C
authors: Martínez
authors: José A
authors: JA
authors: Molina
authors: Hortensia
authors: H
authors: Alonso-Navarro
authors: Félix J
authors: FJ
authors: Jiménez-Jiménez
authors: José A G
authors: JA
authors: Agúndez
authors: Elena
authors: E
authors: García-Martín
mesh_terms: D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001254:Astrocytoma / Q000201:enzymology / Q000235:genetics*; D001932:Brain Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000201:enzymology / Q000235:genetics*; D008579:Meningioma / Q000201:enzymology / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human