title: Evolving microbiology of complicated acute otitis media before and after introduction of the pneumococcal conjugate vaccine in France.
abstract: We compare the microbiology of otopathogens causing recurrent acute otitis media (AOM) or AOM treatment failure in 600 children during 2000 to 2008 before and after the introduction of 7-valent pneumococcal conjugate vaccine (PCV-7). Streptococcus pneumoniae predominated before PCV-7 introduction and during 2007 to 2008, whereas Haemophilus influenzae predominated during 2005 to 2006. S. pneumoniae 19A became the most frequent serotype after PCV-7 introduction.
authors: Service de Microbiologie, Hôpital Robert Debré (AP-HP), Paris, Université Denis-Diderot-Paris7, France.
authors: Damien
authors: D
authors: Dupont
authors: Farah
authors: F
authors: Mahjoub-Messai
authors: Martine
authors: M
authors: François
authors: Catherine
authors: C
authors: Doit
authors: Patricia
authors: P
authors: Mariani-Kurkdjian
authors: Philippe
authors: P
authors: Bidet
authors: Stéphane
authors: S
authors: Bonacorsi
authors: Agnès
authors: A
authors: Carol
authors: Edouard
authors: E
authors: Bingen
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D005602:France / Q000453:epidemiology; D006192:Haemophilus Infections / Q000453:epidemiology / Q000382:microbiology; D006193:Haemophilus influenzae / Q000302:isolation & purification*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010033:Otitis Media / Q000453:epidemiology* / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines