title: A supervised framework for the registration and segmentation of white matter fiber tracts.
abstract: A supervised framework is presented for the automatic registration and segmentation of white matter (WM) tractographies extracted from brain DT-MRI. The framework relies on the direct registration between the fibers, without requiring any intensity-based registration as preprocessing. An affine transform is recovered together with a set of segmented fibers. A recently introduced probabilistic boosting tree classifier is used in a segmentation refinement step to improve the precision of the target tract segmentation. The proposed method compares favorably with a state-of-the-art intensity-based algorithm for affine registration of DTI tractographies. Segmentation results for 12 major WM tracts are demonstrated. Quantitative results are also provided for the segmentation of a particularly difficult case, the optic radiation tract. An average precision of 80% and recall of 55% were obtained for the optimal configuration of the presented method.
authors: Medical Image Processing Laboratory, Biomedical Engineering Department, Tel-Aviv University, 69978 Tel-Aviv, Israel. arnmayer@gmail.com
authors: Arnaldo
authors: A
authors: Mayer
authors: Gali
authors: G
authors: Zimmerman-Moreno
authors: Ran
authors: R
authors: Shadmi
authors: Amit
authors: A
authors: Batikoff
authors: Hayit
authors: H
authors: Greenspan
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity