Transcription factor interplay during Drosophila haematopoiesis.
Transcription factors play a key role in regulating blood cell fate choice and differentiation. In this review, we examine current knowledge of the function and mode of action of the transcription factors implicated in haematopoiesis in Drosophila. We particularly emphasize regulation by transcription factors and cofactors, such as GATA, FOG and RUNX, whose homologues in mammals also control blood cell formation and we discuss the cross talks between these transcriptional regulators at the different stages of haematopoietic cell fate decision.
Waltzer
Lucas
L
Centre de Biologie du Developpement, CNRS, Universite de Toulouse, Toulouse, France. waltzer@cict.fr
Gobert
Vanessa
V
Osman
Dani
D
Haenlin
Marc
M
D000818:Animals; D050657:Core Binding Factor alpha Subunits / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004625:Embryo, Nonmammalian / Q000098:blood supply / Q000196:embryology / Q000378:metabolism; D050980:GATA Transcription Factors / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D050657:Core Binding Factor alpha Subunits; D029721:Drosophila Proteins; D050980:GATA Transcription Factors; D014157:Transcription Factors