title: Systematic review and meta-analysis of enterocolitis after one-stage transanal pull-through procedure for Hirschsprung's disease.
abstract: OBJECTIVE
  The transanal one-stage pull-through procedure (TERPT) has gained worldwide popularity over open and laparoscopic-assisted one-stage techniques in children with Hirschsprung's disease (HD). It offers the advantages of avoiding laparotomy, laparoscopy, scars, abdominal contamination, and adhesions. However, enterocolitis associated with Hirschsprung's disease (HAEC) still remains to be a potentially life-threatening complication after pull-through operation. The reported incidence of HAEC ranges from 4.6 to 54%. This meta-analysis was designed to evaluate postoperative incidence of HAEC following TERPT procedure.
  
  
  METHODS
  A meta-analysis of cases of TERPT reported between 1998 and 2009 was performed. Detailed information was recorded regarding intraoperative details and postoperative complications with particular emphasis on incidence of HAEC. Diagnosis of HAEC in a HD patient was based on the clinical presentation of diarrhoea, abdominal distension, and fever.
  
  
  RESULTS
  Of the 54 published articles worldwide, 27 articles, including 899 patients were identified as reporting entirely TERPT procedure. Postoperative HAEC occurred in 92 patients (10.2%). Recurrent episodes of HAEC were reported in 18 patients (2%). Conservative treatment of HAEC was successful in 75 patients (81.5%), whereas in 17 patients (18.5%) surgical treatment was needed.
  
  
  CONCLUSIONS
  This systematic review reveals that TERPT is a safe and less-invasive procedure with a low incidence of postoperative HAEC.
authors: National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin-12, Ireland.
authors: Elke
authors: E
authors: Ruttenstock
authors: Prem
authors: P
authors: Puri
mesh_terms: D002648:Child; D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D004760:Enterocolitis / Q000209:etiology* / Q000517:prevention & control; D006627:Hirschsprung Disease / Q000601:surgery*; D006801:Humans