title: Influence of solubilizing environments on membrane protein structures.
abstract: Membrane protein structures are stabilized by weak interactions and are influenced by additional interactions with the solubilizing environment. Structures of influenza virus A M2 protein, a proven drug target, have been determined in three different environments, thus providing a unique opportunity to assess environmental influences. Structures determined in detergents and detergent micelles can have notable differences from those determined in lipid bilayers. These differences make it imperative to validate membrane protein structures.
authors: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA. cross@magnet.fsu.edu
authors: Timothy A
authors: TA
authors: Cross
authors: Mukesh
authors: M
authors: Sharma
authors: Myunggi
authors: M
authors: Yi
authors: Huan-Xiang
authors: HX
authors: Zhou
mesh_terms: D000818:Animals; D003902:Detergents / Q000378:metabolism; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D008051:Lipid Bilayers; D008565:Membrane Proteins / Q000737:chemistry*; D008823:Micelles; D008958:Models, Molecular; D014763:Viral Matrix Proteins / Q000737:chemistry* / Q000378:metabolism; D000086082:Viroporin Proteins
chemical_list: D003902:Detergents; D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D008823:Micelles; D014763:Viral Matrix Proteins; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins