title: Protein homeostasis and synaptic plasticity.
abstract: It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity. More recently, several studies have highlighted a function for protein degradation by the ubiquitin proteasome system in synaptic plasticity. These observations suggest that changes in synaptic transmission involve extensive regulation of the synaptic proteome. Here, we review experimental data supporting the idea that protein homeostasis is a regulatory motif for synaptic plasticity.
authors: Department of Synaptic Plasticity, Max Planck Institute for Brain Research, Frankfurt am Main, Germany.
authors: Iván J
authors: IJ
authors: Cajigas
authors: Tristan
authors: T
authors: Will
authors: Erin M
authors: EM
authors: Schuman
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: D009419:Nerve Tissue Proteins