title: Myeloid-derived suppressor cells: natural regulators for transplant tolerance.
abstract: Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.
authors: Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY, USA. peter.boros@mssm.edu
authors: Peter
authors: P
authors: Boros
authors: Jordi C
authors: JC
authors: Ochando
authors: Shu-Hsia
authors: SH
authors: Chen
authors: Jonathan S
authors: JS
authors: Bromberg
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007167:Immunotherapy; D022423:Myeloid Cells / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D016377:Organ Transplantation; D023001:Transplantation Tolerance / Q000276:immunology; D019139:Tumor Escape