Granulomatous interstitial nephritis in chronic lymphocytic leukaemia.
We present a case of granulomatous interstitial nephritis (GIN) associated with chronic lymphocytic leukaemia (CLL). GIN is a rare pathological finding noted in renal biopsy specimens. Furthermore, CLL does not usually cause GIN. In this case, acute renal injury probably resulted from GIN, and urgent dialysis was required, despite sufficient chemotherapy. Immunohistochemical analyses of a biopsy specimen revealed invasion of CD20( +) CLL cells, surrounded by reactive T cells, and granuloma formation. Thus, CLL may induce secondary interstitial nephritis as a granulomatous reaction.
Inoue
Tsutomu
T
Department of Nephrology, Saitama Medical University, Saitama, Japan. t_inoue@saitama-med.ac.jp
Sato
Takahiko
T
Okada
Hirokazu
H
Kayano
Hidekazu
H
Watanabe
Yusuke
Y
Kikuta
Tomohiro
T
Tsuda
Masahiro
M
Sueyoshi
Keita
K
Takenaka
Tsuneo
T
Suzuki
Hiromichi
H
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D017252:CD3 Complex / Q000378:metabolism; D018956:CD5 Antigens / Q000378:metabolism; D002465:Cell Movement; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis* / Q000209:etiology*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D017252:CD3 Complex; D018956:CD5 Antigens