Treatment of HCV infection in patients with cirrhosis.
The treatment of patients with cirrhosis has the following purposes: to prevent the complications of the disease; to allow for the regression of cirrhosis; and to prevent reinfection in the graft in patients undergoing liver transplantation. When the sustained viral response is evaluated in patients with cirrhosis, especially in those with decompensated disease, it is noted to be lower than that of patients with chronic hepatitis, and with a higher possibility of complications of the treatment. Based on a review of the literature, we conclude that we should treat patients with compensated cirrhosis, probably also those with portal hypertension, and patients with decompensated cirrhosis only when included on the transplant list, as long as Child B with HCV genotype 2 (possibly 3) and preferably after clinical compensation.
Alves de Mattos
Angelo
A
Department of Gastroenterology and Post Graduate Course of Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil. angeloamattos@gmail.com
Mattos
Angelo Zambam de
AZ
D000998:Antiviral Agents / Q000627:therapeutic use*; D018450:Disease Progression; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D006975:Hypertension, Portal / Q000821:virology; D008103:Liver Cirrhosis / Q000601:surgery / Q000821:virology*; D016031:Liver Transplantation; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome; D019562:Viral Load; D014850:Waiting Lists
D000998:Antiviral Agents