title: Individual exercise sessions alter circulating hormones and cytokines in HIV-infected men.
abstract: Exercise has the potential to impact disease by altering circulating anabolic and catabolic factors. It was the goal of this study to determine how different regimens of low-intensity and moderate-intensity exercise affected circulating levels of these anabolic and catabolic factors in HIV-infected men. Exercise-naive, HIV-infected men, medically cleared for study participation, were randomized into one of the following groups: a moderate-intensity group (MOD, who completed 30 min of moderate-intensity aerobic training followed by 30 min of moderate-intensity resistance training; a low-intensity group (LOW), who completed 60 min of treadmill walking; or a control group (CON), who attended the clinic but participated in no activity. Blood and saliva samples were collected at selected time points before, during, and after each of the 3 required sessions. Compared with baseline, the MOD group (n=14) had a 135% increase in growth hormone (GH) (p<0.05) and a 34% decrease in cortisol (CORT) (p<0.05) at the post time point, a 31% increase in interleukin-6 (IL-6) (p<0.05) at 30-min post exercise, and a 23% increase in IL-6 (p<0.05) and a 13% decrease in soluble tumor necrosis factor receptor 2 (sTNFrII) (p<0.05) at 60-min post exercise. The LOW (n=11) group had a 3.5% decrease in sTNFrII (<0.05) at 30-min post exercise compared with baseline and a 49% decrease (p<0.05) in GH at 60-min post exercise. The CON group (n=13) had a decrease in GH at 30-min (62%, p<0.05) and 60-min (61%, p<0.05) post exercise compared with baseline. The increase in GH from baseline to post was greater in the MOD group (p<0.05) and the decrease in CORT from pre to post was greater in the MOD group (p<0.05) than in the other groups. These data suggest that individual sessions of both low-intensity and moderate-intensity exercise can alter circulating anabolic and catabolic factors in HIV-infected men. The changes in the MOD group present potential mechanisms for the increases in lean tissue mass seen with resistance exercise training.
authors: Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 1300 Wheat Street, Columbia, SC 29208, USA. wes.dudgeon@citadel.edu
authors: Wesley David
authors: WD
authors: Dudgeon
authors: Kenneth Doyle
authors: KD
authors: Phillips
authors: John Larry
authors: JL
authors: Durstine
authors: Stephanie E
authors: SE
authors: Burgess
authors: George William
authors: GW
authors: Lyerly
authors: John Mark
authors: JM
authors: Davis
authors: Gregory Allen
authors: GA
authors: Hand
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D015658:HIV Infections / Q000097:blood / Q000276:immunology / Q000628:therapy*; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D055070:Resistance Training; D012463:Saliva / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D015415:Biomarkers; D016207:Cytokines; D006728:Hormones; C508600:IL6 protein, human; D015850:Interleukin-6; D047889:Receptors, Tumor Necrosis Factor, Type II; C415902:TNFRSF1B protein, human; D019382:Human Growth Hormone; D006854:Hydrocortisone