Biosynthesis of unnatural papaverine derivatives in Papaver somniferum.
The unnatural thebaine analog, oripavine 3-ethyl ether, was efficiently metabolized to morphine 3-ethyl ether and morphine in the opium poppy. An attempt to detect oripavine hy an isotope dilution experiment based on its presumed biosynthesis from reticuline was unsuccessful.
Brochmann-Hanssen
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Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California 94143, USA.
Chen
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Linn
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D015394:Molecular Structure; D010207:Papaver / Q000737:chemistry* / Q000378:metabolism; D010208:Papaverine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D010208:Papaverine