Bone marrow-derived cells in neovascular age-related macular degeneration: contribution and potential application.
Neovascular age-related macular degeneration, characterized by the formation of choroidal neovascularization (CNV), is a predominant cause of serious loss of vision. The pathogenesis of CNV is complex and still imperfectly understood. Prior studies have shown that bone marrow-derived cells (BMC) play a role in CNV. In this review article, we describe the contribution of BMC to CNV development, and discuss the potential use of BMC in the anticipation and treatment of CNV-associated diseases as well as research needs in the future.
Hou
Hui-Yuan
HY
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Liang
Hong-Liang
HL
Wang
Yu-Sheng
YS
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000209:etiology*; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology*