title: The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents.
abstract: Obesity is characterized as an inflammatory state associated with a modification in the pattern of adipokine secretion. The present study aimed to assess the role of anorexigenic and orexigenic neuropeptides and peripheral signals in obese adolescents submitted to 1 year of weight loss interdisciplinary therapy and grouped according to quartiles of weight loss. A total of 111 post-puberty adolescents, with a BMI >95th percentile, were included. Glycemia and lipid profiles were analyzed. Insulin resistance was estimated by HOMA-IR. Cytokine concentrations were measured by ELISA. The results are presented according to quartiles of weight loss: 1st (<2.5 kg)=low; 2nd (2.5-8 kg)=low to moderate; 3rd (8-14 kg)=moderate; and 4th (>14 kg)=massive. The most important finding was that the NPY concentration increased significantly only in the first phase of weight loss. Moreover, α-MSH variation was an independent factor in explaining the NPY changes during the intervention, confirming the role of the α-MSH concentration in the peripheral control of energy balance in obese adolescents. Indeed, BMI reduction was correlated with increased α-MSH (p<0.05). Massive weight loss promoted a significant increase in α-MSH concentration, and hyperleptinemia was reduced after intervention. All together, our findings, which contribute to our understanding of how orexigenic and anorexigenic systems are regulated by weight loss, will provide insight into the pathogenesis and treatment of obesity and other metabolic diseases, especially in obese adolescents.
authors: Post Graduate Program of Nutrition, Federal University of São Paulo-Unifesp, São Paulo, SP, Brazil.
authors: Lila Missae
authors: LM
authors: Oyama
authors: Claudia Maria Oller
authors: CM
authors: do Nascimento
authors: June
authors: J
authors: Carnier
authors: Aline
authors: A
authors: de Piano
authors: Lian
authors: L
authors: Tock
authors: Priscila de Lima
authors: Pde L
authors: Sanches
authors: Fabíola Alvise Corrêa
authors: FA
authors: Gomes
authors: Sergio
authors: S
authors: Tufik
authors: Marco Túlio
authors: MT
authors: de Mello
authors: Ana R
authors: AR
authors: Dâmaso
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D009765:Obesity / Q000503:physiopathology*; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
chemical_list: D009479:Neuropeptides