Getting one's Fak straight.
Focal adhesion kinase (FAK) is a pivotal regulator of integrin signaling and responses to cell adhesive dynamics. In this issue of Developmental Cell, Ashton et al. demonstrate that Fak is critical for intestinal oncogenesis and regeneration after injury but not for day-to-day homeostasis, providing novel insights into intestinal biology and colorectal cancer therapy.
Evan
Gerard
G
Department of Biochemistry, University of Cambridge, UK. gie20@cam.ac.uk