The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging.
In the past year and a half, five studies have independently established a direct connection between the hypoxic response transcription factor, HIF-1, and aging in Caenorhabditis elegans. These studies demonstrated that HIF-1 can both promote and limit longevity via pathways that are mechanistically distinct. Here, we review the current state of knowledge regarding modulation of aging by HIF-1 and speculate on potential aspects of HIF-1 function that could be relevant for mammalian longevity and healthspan.
Leiser
Scott F
SF
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
Kaeberlein
Matt
M
D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D017353:Gene Deletion; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D008136:Longevity / Q000235:genetics; D055550:Protein Stability
D051793:Hypoxia-Inducible Factor 1