title: [Oral vitamin B12: Efficacy and safety data in 31 patients with pernicious anemia and food-cobalamin malabsorption].
abstract: OBJECTIVE
  The aim of this study is to validate the efficacy and safety of oral cobalamin therapy in the treatment of cobalamin deficiency related to various causes.
  
  
  METHODS
  It's a retrospective study, including 31 patients with documented cobalamin deficiency related to food-cobalamin malabsorption (n=20) and pernicious anemia (n=11). These patients were treated at least for 3 months with oral cyanocobalamin, between 125 to 1000microg per day. Serum cobalamin levels and hematological parameters were compared before and after the therapy and in relation with the nature of cobalamin deficiency. Safety data were also recorded.
  
  
  RESULTS
  After 3 months of therapy, the serum cobalamin levels have significantly increased in all the patients, with a mean of +161.6±79.3pg/mL in the food-cobalamin malabsorption group (P<0,00005) and +136.7±67.4pg/mL in the pernicious anemia group (P<0,0001). Hematological parameters have been normalized in 90 % of the patients, independently of the cause of the cobalamin deficiency. Only 1 patient presented an urticarial reaction.
  
  
  CONCLUSIONS
  This study confirms the efficacy and safety of oral cobalamin therapy in food-cobalamin malabsorption and also in case of pernicious anemia.
authors: Hôpitaux universitaires de Strasbourg, service médecine interne, diabète et maladies métaboliques, clinique médicale B, 67091 Strasbourg cedex, France.
authors: Arianna
authors: A
authors: Troilo
authors: Mustapha
authors: M
authors: Mecili
authors: Ecaterina
authors: E
authors: Ciobanu
authors: Vieri
authors: V
authors: Boddi
authors: Mario M
authors: MM
authors: D'Elios
authors: Emmanuel
authors: E
authors: Andrès
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000752:Anemia, Pernicious / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008286:Malabsorption Syndromes / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D014805:Vitamin B 12