In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus.
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus.
McConeghy
Kevin W
KW
Department of Pharmacy Practice, University of Rhode Island, Veterans Affairs Medical Center (151), Providence, RI 02908, USA.
LaPlante
Kerry L
KL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D008954:Models, Biological; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D003470:Culture Media; D005839:Gentamicins; D000078304:Tigecycline; D008911:Minocycline