title: New insights into the development of lymphoid tissues.
abstract: Secondary lymphoid organs are important locations for the initiation of adaptive immune responses. They develop before birth, and their formation requires interaction between lymphotoxin-α₁ß₂-expressing lymphoid-tissue inducer cells and lymphotoxin-ß receptor-expressing stromal organizer cells. Here, we discuss new insights into the earliest phases of peripheral lymph node and Peyer's patch formation that occur before lymphotoxin-ß receptor signalling and suggest a role for the developing nervous system. In addition, we discuss the differing requirements for the postnatal formation of mucosa-associated lymphoid tissues and tertiary lymphoid structures that develop at sites of chronic inflammation.
authors: Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands. sa.vandepavert@vumc.nl
authors: Serge A
authors: SA
authors: van de Pavert
authors: Reina E
authors: RE
authors: Mebius
mesh_terms: D000818:Animals; D006801:Humans; D008221:Lymphoid Tissue / Q000196:embryology* / Q000254:growth & development* / Q000276:immunology*; D038081:Organogenesis / Q000276:immunology*