Synthesis of beta-maltooligosaccharides of glycitein and daidzein and their anti-oxidant and anti-allergic activities.
The production of beta-maltooligosaccharides of glycitein and daidzein using Lactobacillus delbrueckii and cyclodextrin glucanotransferase (CGTase) as biocatalysts was investigated. The cells of L. delbrueckii glucosylated glycitein and daidzein to give their corresponding 4'- and 7-O-beta-glucosides. The beta-glucosides of glycitein and daidzein were converted into the corresponding beta-maltooligosides by CGTase. The 7-O-beta-glucosides of glycitein and daidzein and 7-O-beta-maltoside of glycitein showed inhibitory effects on IgE antibody production. On the other hand, beta-glucosides of glycitein and daidzein exerted 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity and supeoxide-radical scavenging activity.
Shimoda
Kei
K
Department of Chemistry, Faculty of Medicine, Oita University, Hasama-machi, Oita, Japan. shimoda@med.oita-u.ac.jp
Hamada
Hiroki
H
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology; D007073:Immunoglobulin E / Q000276:immunology; D007529:Isoflavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D018926:Anti-Allergic Agents; D000975:Antioxidants; D006027:Glycosides; D007529:Isoflavones; D009844:Oligosaccharides; C021705:maltooligosaccharides; D007073:Immunoglobulin E; C004742:daidzein; C086566:glycitein