title: The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
abstract: The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
authors: Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. pharring@amgen.com
authors: Paul E
authors: PE
authors: Harrington
authors: David J
authors: DJ
authors: St Jean
authors: Jeffrey
authors: J
authors: Clarine
authors: Thomas S
authors: TS
authors: Coulter
authors: Michael
authors: M
authors: Croghan
authors: Adam
authors: A
authors: Davenport
authors: James
authors: J
authors: Davis
authors: Chiara
authors: C
authors: Ghiron
authors: Jonathan
authors: J
authors: Hutchinson
authors: Michael G
authors: MG
authors: Kelly
authors: Fred
authors: F
authors: Lott
authors: Jenny Ying-Lin
authors: JY
authors: Lu
authors: David
authors: D
authors: Martin
authors: Sean
authors: S
authors: Morony
authors: Steve F
authors: SF
authors: Poon
authors: Elena
authors: E
authors: Portero-Larragueta
authors: Jeff D
authors: JD
authors: Reagan
authors: Kelly A
authors: KA
authors: Regal
authors: Andrew
authors: A
authors: Tasker
authors: Minghan
authors: M
authors: Wang
authors: Yuhua
authors: Y
authors: Yang
authors: Guomin
authors: G
authors: Yao
authors: Qingping
authors: Q
authors: Zeng
authors: Charles
authors: C
authors: Henley
authors: Christopher
authors: C
authors: Fotsch
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001596:Benzylamines / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors* / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044169:Receptors, Calcium-Sensing / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001596:Benzylamines; D010281:Parathyroid Hormone; D044169:Receptors, Calcium-Sensing; C005051:dibenzylamine