Hypolipidemic effect of bamboo shoot oil (P. pubescens) in Sprague-Dawley rats.
Atherosclerosis and its related complications are the leading causes of death in the West and in many developed countries. This study aims to investigate the hypolipidemic effect of bamboo shoot oil (BSO) in Sprague-Dawley rats. A group of rats had induced hyperlipidemia, hypercholesterolemia, and fatty liver by being fed with a high-fat, high-cholesterol diet for 4 wk. The control group was administered 10 mL distilled water per kg body weight, while the other groups were, respectively, administered 250 mg beta-sitosterol, 250 mg BSO, 500 mg BSO, and 1000 mg BSO per kg body weight by oral gavage. The results demonstrated that BSO could significantly decrease the levels of total cholesterol, triacylglycerol, low-density lipoprotein-cholesterol, phytosterol, lipoprotein lipase, hepatic lipase, and atherogenic index in serum, and increase the levels of cholesterol in feces. It could also significantly decrease the level of relative liver weight and liver lipids. The pronounced hypolipidemic effects of BSO might be attributed to its ability to inhibit cholesterol absorption and increase cholesterol excretion. These results suggest that consuming BSO may provide benefits in managing hypercholesterolemia. Therefore, BSO may be a good candidate for development as a functional food and nutraceutical.
Lu
Baiyi
B
Dept. of Food Science and Nutrition, Zhejiang Univ., Hangzhou, China.
Xia
Daozhong
D
Huang
Weisu
W
Wu
Xiaoqin
X
Zhang
Ying
Y
Yao
Yiyuan
Y
D000818:Animals; D002784:Cholesterol / Q000032:analysis / Q000097:blood / Q000378:metabolism; D004036:Diet, Atherogenic; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000473:pathology; D005243:Feces / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000032:analysis / Q000097:blood / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010840:Phytosterols / Q000032:analysis / Q000097:blood / Q000737:chemistry; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D018520:Plant Shoots / Q000737:chemistry*; D006109:Poaceae / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000960:Hypolipidemic Agents; D008055:Lipids; D010840:Phytosterols; D010938:Plant Oils; D002784:Cholesterol