title: Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence.
abstract: Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions.Aging-regulating genes p66shc, Sirtuin, FOXO3a and Klotho are new important factors which are stimulated by ROS signaling. It has been shown that ROS participate in initiation and prolongation of gene-dependent aging development.ROS also participate in the activation of protein kinases Akt/PKB and extracellular signal-regulated kinase ERK, which by themselves or through gene activation stimulates or retards cell senescence.Different retarding/stimulating effects of ROS might depend on the nature of signaling species-superoxide or hydrogen peroxide. Importance of radical anion superoxide as a signaling molecule with"super-nucleophilic" properties points to the possibility of the use of superoxide scavengers (SOD mimetics, ubiquinones and flavonoids) for retarding the development of aging.
authors: Vitamin Research Institute; Moscow, Russia. iafananizer@gmail.com
authors: Igor
authors: I
authors: Afanas'ev
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D000090265:Klotho Proteins; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000378:metabolism*; D055765:Shc Signaling Adaptor Proteins / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D051858:Forkhead Transcription Factors; D017382:Reactive Oxygen Species; D055765:Shc Signaling Adaptor Proteins; D005966:Glucuronidase; D000090265:Klotho Proteins; D037761:Sirtuins