title: Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage.
abstract: Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.
authors: Korea Advanced Institute of Science and Technology, Daejeon, Korea.
authors: Young Jun
authors: YJ
authors: Koh
authors: Hak-Zoo
authors: HZ
authors: Kim
authors: Seong-Ik
authors: SI
authors: Hwang
authors: Jeung Eun
authors: JE
authors: Lee
authors: Nuri
authors: N
authors: Oh
authors: Keehoon
authors: K
authors: Jung
authors: Minah
authors: M
authors: Kim
authors: Kyung Eun
authors: KE
authors: Kim
authors: Homin
authors: H
authors: Kim
authors: Nam-Kyu
authors: NK
authors: Lim
authors: Choon-Ju
authors: CJ
authors: Jeon
authors: Gyun Min
authors: GM
authors: Lee
authors: Byeong Hwa
authors: BH
authors: Jeon
authors: Do-Hyun
authors: DH
authors: Nam
authors: Hoon Ki
authors: HK
authors: Sung
authors: Andras
authors: A
authors: Nagy
authors: Ook Joon
authors: OJ
authors: Yoo
authors: Gou Young
authors: GY
authors: Koh
mesh_terms: D020533:Angiogenesis Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D042682:Angiopoietins / Q000037:antagonists & inhibitors*; D000818:Animals; D002199:Capillary Permeability; D045744:Cell Line, Tumor; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
chemical_list: D020533:Angiogenesis Inhibitors; D042682:Angiopoietins; D042461:Vascular Endothelial Growth Factor A