Toward a B-cell signature of tolerance?
Operational tolerance is a rare and still unexplained phenomenon in organ transplantation. Pallier et al. analyzed the peripheral B-cell compartment of 12 renal transplant patients with drug-free long-term graft function and found a peculiar blood B-cell phenotype, with an expansion of memory activated B cells and increased expression of inhibitory molecules, suggesting a role of B cells in maintaining graft tolerance.
Cugini
Daniela
D
Department of Immunology and Organ Transplantation, Ospedali Riuniti-Mario Negri Institute for Pharmacological Research, Center for Research on Organ Transplantation Chiara Cucchi de Alessandri e Gilberto Crespi, Ranica, Italy. daniela.cugini@marionegri.it
Noris
Marina
M
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D016030:Kidney Transplantation / Q000276:immunology*; D008565:Membrane Proteins / Q000502:physiology; D017452:Receptors, IgG / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D048868:Adaptor Proteins, Signal Transducing; C447641:BANK1 protein, human; C080571:Fc gamma receptor IIB; D008565:Membrane Proteins; D017452:Receptors, IgG