Thymoma associated with malignancies may herald a hereditary cancer syndrome.
Two probands with thymoma and other primary malignancies with multiple cancer patients in the family are described. Types of malignancies, pattern of pedigree and age of the patients do not match the known familial cancer syndromes. One proband was a very rare case with five discrete primary malignancies; TP53 sequencing and karyotyping did not reveal any mutations. These cases suggest thymoma associated malignancies may herald a hereditary cancer syndrome.
Tehrani
Omid Saeed
OS
Department of Internal Medicine, Capital Health System, 750 Brunswick Ave, Trenton, NJ 08638, USA. ostehrany@yahoo.com
Chen
Emily Q
EQ
Schaebler
David L
DL
Mughal
Abdul W
AW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005820:Genetic Testing; D018095:Germ-Line Mutation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary; D010375:Pedigree; D013945:Thymoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53