Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.
A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC(50) values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.
Peng
Jiangnan
J
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Jackson
Evelyn M
EM
Babinski
David J
DJ
Risinger
April L
AL
Helms
Gregory
G
Frantz
Doug E
DE
Mooberry
Susan L
SL
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027743:Dioscoreaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D027343:Rhizome / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D047188:Chalcones; C552992:evelynin; C015812:dihydrochalcone