Protective effect of resolvin E1 on the development of asthmatic airway inflammation.
Resolvin E1 (RvE1) is an anti-inflammatory lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA), and strongly acts in the resolution of inflammation. We previously reported that RvE1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma. In the present study, to elucidate the effects of RvE1 on the development of asthmatic airway inflammation, we investigated whether RvE1 acts on different phases of an OVA-sensitized and -challenged mouse model of asthma. RvE1 treatments at the time of either OVA sensitization or at the time of OVA challenge were investigated and compared with RvE1 treatments at the time of both OVA sensitization and challenge. After RvE1 was administered to mice intraperitoneally at the time of both OVA sensitization and challenge, there were decreases in airway eosinophil and lymphocyte recruitment, as well as a reduction in Th2 cytokine and airway hyperresponsiveness. RvE1 treatment at the time of either OVA sensitization or challenge also improved AHR and airway inflammation. Our results suggest that RvE1 acts on several phases of asthmatic inflammation and may have anti-inflammatory effects on various cell types.
Aoki
Haruka
H
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
Hisada
Takeshi
T
Ishizuka
Tamotsu
T
Utsugi
Mitsuyoshi
M
Ono
Akihiro
A
Koga
Yasuhiko
Y
Sunaga
Noriaki
N
Nakakura
Takashi
T
Okajima
Fumikazu
F
Dobashi
Kunio
K
Mori
Masatomo
M
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000517:prevention & control; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D011014:Pneumonia / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control
D010047:Ovalbumin; D015118:Eicosapentaenoic Acid; C499823:5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid