title: Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing.
abstract: A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Phi(Delta) = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.
authors: Faculty of Material Science & Chemistry Engineering, China University of Geosciences, Wuhan, Hubei 430074, P. R. China.
authors: Hanzhong
authors: H
authors: Ke
authors: Hongda
authors: H
authors: Wang
authors: Wai-Kwok
authors: WK
authors: Wong
authors: Nai-Ki
authors: NK
authors: Mak
authors: Daniel W J
authors: DW
authors: Kwong
authors: Ka-Leung
authors: KL
authors: Wong
authors: Hoi-Lam
authors: HL
authors: Tam
mesh_terms: D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D007259:Infrared Rays; D008928:Mitochondria / Q000187:drug effects*; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry / Q000633:toxicity; D012428:Ruthenium / Q000737:chemistry*; D026082:Singlet Oxygen / Q000378:metabolism / Q000633:toxicity; D014466:Ultraviolet Rays
chemical_list: D056831:Coordination Complexes; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D012428:Ruthenium