title: Epidemiology and prognosis of ovarian metastases in colorectal cancer.
abstract: BACKGROUND
  National guidelines for prophylactic oophorectomy in women with colorectal cancer are lacking. The aim of this population-based cohort study was to report on the prevalence, incidence and prognosis of ovarian metastases from colorectal cancer, providing information relevant to the discussion of prophylactic oophorectomy.
  
  
  METHODS
  All 4566 women with colorectal cancer in Stockholm County during 1995-2006 were included and followed until 2008. Prospectively collected data regarding clinical characteristics, treatment and outcome were obtained from the Regional Quality Registry.
  
  
  RESULTS
  The prevalence of ovarian metastases at the time of diagnosis of colorectal cancer was 1.1 per cent (34 of 3172) among women with colonic cancer and 0.6 per cent (8 of 1394) among those with rectal cancer (P = 0.105). After radical resection of stage I-III colorectal cancer, metachronous ovarian metastases were found during follow-up in 1.1 per cent (22 of 1971) with colonic cancer and 0.1 per cent (1 of 881) with rectal cancer (P = 0.006). Survival in patients with ovarian metastases was poor.
  
  
  CONCLUSIONS
  Ovarian metastases from colorectal cancer are uncommon.
authors: Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden. josefin.segelman@ki.se
authors: J
authors: J
authors: Segelman
authors: A
authors: A
authors: Flöter-Rådestad
authors: H
authors: H
authors: Hellborg
authors: A
authors: A
authors: Sjövall
authors: A
authors: A
authors: Martling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000601:surgery; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult