Antioxidant activity of butyl- and phenylstannoxanes derived from 2-, 3- and 4-pyridinecarboxylic acids.
In vitro antioxidant activity for 12 stannoxanes derived from Ph(3)SnCl (compounds 1-3), Ph(2)SnCl(2) (compounds 4-6), Bu(3)SnCl (compounds 7-9), and Bu(2)SnCl(2) (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1-diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridine- carboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 microg/mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported.
Corona-Bustamante
Alicia
A
Facultad de Ciencias Químicas, Universidad de Colima, kilómetro 9 carretera Colima, Coquimatlán, Col. Mexico, Mexico.
Viveros-Paredes
Juan Manuel
JM
Flores-Parra
Angelina
A
Peraza-Campos
Ana Lilia
AL
Martínez-Martínez
Francisco J
FJ
Sumaya-Martínez
María Teresa
MT
Ramos-Organillo
Angel
A
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002855:Chromatography, Thin Layer; D036681:Fluorescence Recovery After Photobleaching; D016166:Free Radical Scavengers / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D008024:Ligands; D009539:Nicotinic Acids / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry / Q000494:pharmacology*
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D008024:Ligands; D009539:Nicotinic Acids; D010851:Picrates; D017971:Tin Compounds; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron