Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
The genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59%) to extremely (0.5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese.
Lan
Qing
Q
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA. qingl@mail.nih.gov
Au
Wing-Yan
WY
Chanock
Stephen
S
Tse
Jovic
J
Wong
Kit-fai
KF
Shen
Min
M
Siu
L P
LP
Yuenger
Jeff
J
Yeager
Meredith
M
Hosgood
Howard Dean
HD
Purdue
Mark P
MP
Liang
Raymond
R
Rothman
Nathaniel
N
D000483:Alleles; D034961:Antigens, Nuclear / Q000235:genetics; D044466:Asian People; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics; D006113:United Kingdom; D044465:White People; D000099218:Interferon Regulatory Factor-4
D034961:Antigens, Nuclear; D050835:Interferon Regulatory Factors; D014157:Transcription Factors; D000099218:Interferon Regulatory Factor-4; C102470:SP140 protein, human