title: Autoantibodies to cardiac troponin in acute coronary syndromes.
abstract: BACKGROUND
  In a recent small study, patients with autoantibodies to cardiac troponin (cTnaAb) had higher cardiac troponin I (cTnI) release during an episode of acute coronary syndrome (ACS) than patients without cTnaAb and continued to have higher long-term levels of cTnI. However, the prognostic importance of the occurrence of cTnaAb is unknown.
  
  
  METHODS
  In 957 nonST-elevation ACS patients cTnaAb and cTnI were analyzed at randomization and after 6 months. Outcomes were assessed through 5 years.
  
  
  RESULTS
  Seven and 11% of the patients were cTnaAb positive at inclusion and 6months, respectively. The cardiac troponin I (cTnI) concentration at inclusion was independently associated with the development of cTnaAb (OR 1.53, 95% CI 1.25-1.88). The presence of cTnaAb was associated with an increased cTnI level at 6 months (OR 2.39, 95% CI 1.50-3.81). cTnaAb was not independently associated with death and AMI during follow-up (HR 0.97, 95% CI 0.61-1.54).
  
  
  CONCLUSIONS
  Development of cTnaAb after an episode of nonST-elevation ACS is associated with the acute myocardial damage, but occurs only in a minority of patients. Furthermore, the presence of cTnaAb is associated with chronically elevated cTnI concentrations. However, the occurrence of cTnaAb is not associated with an adverse long-term prognosis.
authors: Department of Medical Sciences and Uppsala Clinical Research Center, University of Uppsala, Sweden. bertil.lindahl@ucr.uu.se
authors: Bertil
authors: B
authors: Lindahl
authors: Per
authors: P
authors: Venge
authors: Kai M
authors: KM
authors: Eggers
authors: Rolf
authors: R
authors: Gedeborg
authors: Noora
authors: N
authors: Ristiniemi
authors: Saara
authors: S
authors: Wittfooth
authors: Kim
authors: K
authors: Pettersson
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000276:immunology; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000276:immunology; D011379:Prognosis; D019210:Troponin I / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D019210:Troponin I