The role of the corpus callosum in transcranial magnetic stimulation induced interhemispheric signal propagation.
BACKGROUND
The corpus callosum, the main interhemispheric connection in the brain, may serve to preserve functional asymmetry between homologous cortical regions.


METHODS
To test this hypothesis, 30 healthy adult subjects underwent combined transcranial magnetic stimulation (TMS)-electroencephalography procedures. Nineteen of these subjects also completed diffusion tensor imaging and tractography procedures. We examined the relationship between microstructural integrity of subdivisions of the corpus callosum with TMS-induced interhemispheric signal propagation.


RESULTS
We found a significant inverse relationship between microstructural integrity of callosal motor fibers with TMS-induced interhemispheric signal propagation from left to right motor cortex. We also found a significant inverse relationship between microstructural integrity of genu fibers of the corpus callosum and TMS-induced interhemispheric signal propagation from left to right dorsolateral prefrontal cortex (DLPFC). We then demonstrated neuroanatomic specificity of these relationships.


CONCLUSIONS
Taken together, our findings suggest that TMS-induced interhemispheric signal propagation is transcallosally mediated and neuroanatomically specific and support a role for the corpus callosum in preservation of functional asymmetry between homologous cortical regions. Delineation of the relationship between corpus callosum microstructure and interhemispheric signal propagation in neuropsychiatric disorders, such as schizophrenia, may reveal novel mechanisms of pathophysiology.
Voineskos
Aristotle N
AN
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada.
Farzan
Faranak
F
Barr
Mera S
MS
Lobaugh
Nancy J
NJ
Mulsant
Benoit H
BH
Chen
Robert
R
Fitzgerald
Paul B
PB
Daskalakis
Zafiris J
ZJ
D000328:Adult; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000502:physiology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*