title: Despite identifying some shared gene associations with human atopic dermatitis the use of multiple dog breeds from various locations limits detection of gene associations in canine atopic dermatitis.
abstract: Canine atopic dermatitis (cAD) is a common, severe pruritic and inflammatory skin disease and is a major veterinary welfare issue. This study genotyped 97 single nucleotide polymorphisms (SNPs) in 25 candidate genes in 659 dogs across eight breeds from three locations (UK, USA and Japan). These genes were selected from hAD literature, and previous cAD gene expression experiments. The aim of this study was to identify any shared gene associations between cAD and hAD. Only one SNP within the TSLP-receptor was associated with all eight breeds (corrected p=0.037). Five SNPs within Filaggrin, DPP4, MS4A2, and INPPL1 were associated with cAD, but only in certain breeds from different locations. Though these associations are broadly similar to hAD the variability of results across the breeds and locations demonstrates that a candidate gene approach using mixed breeds from different locations is not appropriate. This study therefore suggests that further candidate gene studies in cAD should be breed and location specific to increase the likelihood of finding associations with the disease.
authors: Department of Comparative Molecular Medicine, School of Veterinary Science, The University of Liverpool, Liverpool, UK. shona.wood@liv.ac.uk
authors: Shona H
authors: SH
authors: Wood
authors: William E
authors: WE
authors: Ollier
authors: Tim
authors: T
authors: Nuttall
authors: Neil A
authors: NA
authors: McEwan
authors: Stuart D
authors: SD
authors: Carter
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics* / Q000276:immunology; D004285:Dogs / Q000235:genetics* / Q000276:immunology; D000091344:Filaggrin Proteins; D056726:Genetic Association Studies; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D018121:Receptors, Cytokine / Q000235:genetics; D013045:Species Specificity; D006113:United Kingdom; D014481:United States
chemical_list: C498762:CRLF2 protein, human; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D018121:Receptors, Cytokine