Syntheses, structural characterization and CO releasing properties of boranocarbonate [H3BCO2H]- derivatives.
CO plays an important role in biological processes and molecules which release CO in a controllable way could therefore be used for medicinal purposes. Beside organometallic carbonyl complexes, boranocarbonate [H(3)BCO(2)H](-) is one of the most promising candidates but releases CO too rapidly. In order to delay the CO release, we have prepared boranocarbamates [H(3)BCONH-R](-) from [H(3)BCO(2)H](-) which comprise histamine, morpholine, aniline and ethylene-diamine bound via amides to the {H(3)BCO} moiety. The syntheses of the new derivatives is described together with their structural characterization. These compounds release CO at a much slower rate than the parent compound and are therefore potential CO releasing molecules for biological and medicinal application.
Pitchumony
Tamil Selvi
TS
University of Zürich, Institute of Inorganic Chemistry, Winterthurerstr. 190, 8057, Zürich, Switzerland.
Spingler
Bernhard
B
Motterlini
Roberto
R
Alberto
Roger
R
D001880:Boranes / Q000138:chemical synthesis / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002254:Carbonates / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure
D001880:Boranes; D002254:Carbonates; C503854:sodium boranocarbonate; D002248:Carbon Monoxide