title: The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis.
abstract: BACKGROUND
  Achieving pulp anesthesia with irreversible pulpitis is difficult. This study evaluated whether nonsteroidal anti-inflammatory drugs assist local anesthesia.
  
  
  METHODS
  In a randomized double-blinded clinical trial, 150 patients (50 per group) with irreversible pulpitis were given placebo, 600 mg ibuprofen, or 75 mg indomethacin 1 hour before local anesthesia. Each patient recorded their pain score on a visual analog scale before taking the medication, 15 minutes after anesthesia in response to a cold test, during access cavity preparation and during root canal instrumentation. No or mild pain at any stage was considered a success. Data were analyzed by the chi-square and analysis of variance tests.
  
  
  RESULTS
  Overall success rates for placebo, ibuprofen, and indomethacin were 32%, 78%, and 62%, respectively (p < 0.001). Ibuprofen and indomethacin were significantly better than placebo (p < 0.01). There was no difference between ibuprofen and indomethacin (p = 0.24).
  
  
  CONCLUSIONS
  Premedication with ibuprofen and indomethacin significantly increased the success rates of inferior alveolar nerve block anesthesia for teeth with irreversible pulpitis.
authors: Oral and Dental Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors: Masoud
authors: M
authors: Parirokh
authors: Rezvan
authors: R
authors: Ashouri
authors: Ali Reza
authors: AR
authors: Rekabi
authors: Nouzar
authors: N
authors: Nakhaee
authors: Abbas
authors: A
authors: Pardakhti
authors: Sara
authors: S
authors: Askarifard
authors: Paul V
authors: PV
authors: Abbott
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use*; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008334:Mandible; D008340:Mandibular Nerve / Q000187:drug effects; D008963:Molar; D009407:Nerve Block / Q000379:methods; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D011229:Preanesthetic Medication / Q000379:methods; D011292:Premedication / Q000379:methods*; D011446:Prospective Studies; D011671:Pulpitis / Q000150:complications / Q000601:surgery*; D012390:Root Canal Therapy / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008012:Lidocaine; D007052:Ibuprofen; D007213:Indomethacin