[Prediction of adverse pregnancy outcome by first-trimester maternal serum PAPP-A].
Preeclampsia occurs in 2 to 5% of all pregnancies in developed countries. Together with IUGR it consists one of the leading reasons for perinatal death and childhood handicap. This is why many authors are looking for a widely usable and easy to perform test for evaluation of the patients at risk for preeclampsia an IUGR. PAPP-A is a protein complex produced by the developing trophoblast which is used as a marker for Downs' syndrome. Previous studies have shown an association between low first trimester maternal serum PAPP-A and subsequent development of pregnancy complications.
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D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A
D011266:Pregnancy-Associated Plasma Protein-A