Organocatalytic synthesis of spiro compounds via a cascade Michael-Michael-aldol reaction.
The synthesis of spiro compounds via a Michael-Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivities.
Companyó
Xavier
X
Department de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain.
Zea
Alex
A
Alba
Andrea-Nekane R
AN
Mazzanti
Andrea
A
Moyano
Albert
A
Rios
Ramon
R
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D013141:Spiro Compounds