Hereditary isolated ossicular anomalies in two generations of patients.
We present herein a report of an isolated form of ossicular anomaly that affected two generations of patients. Two female patients, a mother and daughter, were admitted with complaints of conductive hearing loss, with no other anomalies and no history of ear infection. Surgical exploration revealed identical ossicular anomalies: the complete absence of the long process of the incus and fixation of the stapes. This anomaly can be considered to have been inherited in an autosomal-dominant or X-linked-dominant manner. To date, two reports have described isolated forms of congenital ossicular anomalies. Our findings suggest that isolated congenital anomalies can be inherited.
Nakanishi
Hiroshi
H
Department of Otolaryngology, Hamamatsu University School of Medicine, Higashi-ku, Japan. hiro-na@hama-med.ac.jp
Mizuta
Kunihiro
K
Hamada
Noboru
N
Iwasaki
Satoshi
S
Mineta
Hiroyuki
H
D000328:Adult; D002648:Child; D004429:Ear Ossicles / Q000002:abnormalities*; D005260:Female; D006314:Hearing Loss, Conductive / Q000151:congenital; D006801:Humans; D007188:Incus / Q000002:abnormalities; D013199:Stapes / Q000002:abnormalities