title: A theoretical assessment of the effects of smoking on the transmission dynamics of tuberculosis.
abstract: Smoking has long being associated with tuberculosis. We present a tuberculosis dynamics model taking into account the fact that some people in the population are smoking in order to assess the effects of smoking on tuberculosis transmission. The epidemic thresholds known as the reproduction numbers and equilibria for the model are determined and stabilities analyzed. Qualitative analysis of the model including positivity and persistence of solutions are presented. The model is numerically analyzed to assess the effects of smoking on the transmission dynamics of tuberculosis. Numerical simulations of the model show that smoking enhances tuberculosis transmission, progression to active disease and in a population of smokers, tuberculosis cannot be controlled even when treatment success is assumed to be as high as 88%. Further, analysis of the reproduction numbers indicates that the number of active tuberculosis cases increases as the number of smokers increase.
authors: Department of Applied Mathematics, Modelling Biomedical Systems Research Group, National University of Science and Technology, Ascot, Bulawayo, Zimbabwe. cpbhunu@gmail.com
authors: C P
authors: CP
authors: Bhunu
authors: S
authors: S
authors: Mushayabasa
authors: J M
authors: JM
authors: Tchuenche
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D050936:Basic Reproduction Number; D003198:Computer Simulation; D006801:Humans; D018448:Models, Immunological; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012907:Smoking / Q000009:adverse effects / Q000276:immunology*; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology* / Q000635:transmission*
chemical_list: D000995:Antitubercular Agents