Social play impairment following status epilepticus during early development.
Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
Castelhano
Adelisandra Silva Santos
AS
Programa de Pós-graduação em Distúrbios do Desenvolvimento, Laboratório de Neurobiologia, Universidade Presbiteriana Mackenzie (UPM), Rua da Consolação, 930. Prédio 38, CEP 01302-907 São Paulo, SP, Brazil.
Scorza
Fulvio Alexandre
FA
Teixeira
Maria Cristina Triguero Veloz
MC
Arida
Ricardo Mario
RM
Cavalheiro
Esper Abrão
EA
Cysneiros
Roberta Monterazzo
RM
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D001523:Mental Disorders / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology*; D017397:Prefrontal Cortex / Q000254:growth & development / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012919:Social Behavior; D013226:Status Epilepticus / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D013788:Thalamus / Q000254:growth & development / Q000473:pathology