title: Thrombotic microangiopathy in allogeneic stem cell transplantation in childhood.
abstract: OBJECTIVE
  We define the incidence, risk factors, and mortality rates for the occurrence of thrombotic microangiopathy in 50 children who underwent transplants between January 2006 and June 2008 at 2 Turkish pediatric centers.
  
  
  METHODS
  The diagnosis of thrombotic microangiopathy was done according to the reports of International Working Group in 2007.
  
  
  RESULTS
  Fifty patients (27 male and 23 female; age range, 3 months to 18 years) were included. Patients with malignant and nonmalignant diseases were 13 (26%) and 37 (74%). Myeloablative and nonmyeloablative conditioning regimens were used in 29 (58%) and 21 patients (42%). Bone marrow was used as the source of stem cells in 32 patients (62%) and peripheral blood was used in 18 patients (36%). Thrombotic microangiopathy was seen in 3 of 50 cases (6%). Thrombotic microangiopathy developed in 3 of 18 patients in whom peripheral blood was used as the source of stem cells while none of 32 patients who had bone marrow as the source developed thrombotic microangiopathy (P < .05).
  
  
  CONCLUSIONS
  Using peripheral blood as a source of stem cells is a risk factor for development of thrombotic microangiopathy.
authors: Cukurova University Faculty of Medicine, Department of Pediatric Oncology & Pediatric Bone Marrow Transplantation Unit, Adana, Turkey. erbeyfa@gmail.com
authors: Fatih
authors: F
authors: Erbey
authors: Ibrahim
authors: I
authors: Bayram
authors: Baris
authors: B
authors: Kuskonmaz
authors: Sema
authors: S
authors: Yilmaz
authors: Mualla
authors: M
authors: Cetin
authors: Duygu
authors: D
authors: Uckan
authors: Atila
authors: A
authors: Tanyeli
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000401:mortality; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D057049:Thrombotic Microangiopathies / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology