title: Relation of left ventricular twist and global strain with right ventricular dysfunction in patients after operative "correction" of tetralogy of fallot.
abstract: In patients with corrected tetralogy of Fallot (cToF), left ventricular (LV) dysfunction is closely related to right ventricular (RV) dysfunction, indicating adverse ventricular-ventricular interactions. However, the mechanism that links RV dysfunction to LV dysfunction remains unclear. In this prospective study, 32 patients with cToF and 19 controls were enrolled. With cardiac magnetic resonance imaging, biventricular ejection fractions were assessed. Using 2-dimensional speckle tracking, global and regional RV and LV strains and LV twist were assessed. To detect and characterize ventricular-ventricular interaction, the relation between global and regional RV mechanics and global and regional LV mechanics was assessed. Global RV strain, global LV strain, and LV twist were decreased in patients with cToF. Global RV strain correlated with global LV strain (r = 0.66, p <0.001) and LV twist (r = -0.72, p <0.001), indicating the presence of adverse ventricular-ventricular interaction. Furthermore, close relations were observed between apical RV strain and apical LV strain (r = 0.62, p <0.001) and apical LV rotation (r = -0.67, p <0.001). In conclusion, RV strain was significantly related to LV strain and LV twist in patients with cToF and controls. Furthermore, apical RV strain correlated with apical LV strain and apical LV rotation, indicating adverse apical ventricular-ventricular interactions.
authors: Department of Pediatric Cardiology, Leiden, The Netherlands.
authors: Annelies E
authors: AE
authors: van der Hulst
authors: Victoria
authors: V
authors: Delgado
authors: Eduard R
authors: ER
authors: Holman
authors: Lucia J M
authors: LJ
authors: Kroft
authors: Albert
authors: A
authors: de Roos
authors: Mark G
authors: MG
authors: Hazekamp
authors: Nico A
authors: NA
authors: Blom
authors: Jeroen J
authors: JJ
authors: Bax
authors: Arno A W
authors: AA
authors: Roest
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013314:Stress, Mechanical; D013318:Stroke Volume; D013771:Tetralogy of Fallot / Q000150:complications* / Q000503:physiopathology* / Q000601:surgery; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000502:physiology*