title: Long-term functional outcome and health status of patients with critical illness polyneuromyopathy.
abstract: OBJECTIVE
  The aim of this study was to investigate the long-term functional outcome and health status of patients with critical illness polyneuromyopathy (CIPNM).
  
  
  METHODS
  One hundred and twenty-four consecutive survival intensive care unit patients admitted to a neuro-rehabilitation Unit from January 2003 to December 2007 were identified. Patients with proven CIPNM by the electromyography were prospectively followed. The Barthel and modified Rankin Scales (mRS) were administered to all patients at baseline, discharge and follow-up. The SF-36 questionnaire was administered to ascertain health status. Each patient underwent an individually tailored rehabilitation therapy.
  
  
  RESULTS
  Forty-two subjects (23M, 19F, mean age 58.4 ± 13.9) were enrolled. Of these, 30 patients were diagnosed electrophysiologically with CIP, six with critical illness myopathy (CIM) and six with a finding combination of CIP and CIM (CIP/CIM) subtype. The mean Barthel scores at baseline, discharge and follow-up were 16.7 ± 8.6, 81.7 ± 16.4 and 86.7 ± 15.9 (P < 0.001) and the median mRS scores were 5 (IQR: 5-5), 3 (IQR: 0-5) and 1 (IQR: 0-5). The mean length of neuro-rehabilitation stay was 76.2 ± 28.1 days. The SF-36 questionnaire administered at follow-up (mean 31.7 ± 15.8 months), showed significantly lower values compared to Italian normative.
  
  
  CONCLUSIONS
  ICU patients with CIPNM treated in a neuro-rehabilitation setting resulted in a good functional outcome. Despite complete recovery, patients with CIPNM experienced difficulties in health status.
authors: Scientific Institute 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Foggia, Italy. d.intiso@operapadrepio.it
authors: D
authors: D
authors: Intiso
authors: L
authors: L
authors: Amoruso
authors: M
authors: M
authors: Zarrelli
authors: L
authors: L
authors: Pazienza
authors: M
authors: M
authors: Basciani
authors: G
authors: G
authors: Grimaldi
authors: A
authors: A
authors: Iarossi
authors: F
authors: F
authors: Di Rienzo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000175:diagnosis* / Q000503:physiopathology / Q000534:rehabilitation*; D011446:Prospective Studies; D013995:Time; D013997:Time Factors