Aerobic capacity of rats recovered from fetal malnutrition with a fructose-rich diet.
The objective of this study was to analyze the aerobic capacity, through the maximal lactate steady-state (MLSS) protocol, of rats subjected to fetal protein malnutrition and recovered with a fructose-rich diet. Pregnant adult Wistar rats that were fed a balanced (17% protein) diet or a low-protein (6% protein) diet were used. After birth, the offspring were distributed into groups according to diet until 60 days of age: balanced (B), balanced diet during the whole experimental period; balanced-fructose (BF), balanced diet until birth and fructose-rich diet (60% fructose) until 60 days; low protein-balanced (LB), low-protein diet until birth and balanced diet until 60 days; and low protein-fructose (LF), low protein diet until birth and fructose-rich diet until 60 days. It was verified that the fructose-rich diet reduced body growth, mainly in the BF group. There was no difference among the groups in the load corresponding to the MLSS (B, 7.5+/-0.5%; BF, 7.4+/-0.6%; LB, 7.7+/-0.4%; and LF, 7.7+/-0.6% relative to body weight). However, the BF group presented higher blood lactate concentrations (4.8+/-0.9 mmol.L(-1)) at 25 min in the load corresponding to the MLSS (B, 3.2+/-0.9 mmol.L(-1); LB, 3.4+/-0.9 mmol.L(-1); and LF, 3.2+/-1.0 mmol.L(-1)). Taken together, these results indicate that the ability of young rats to perform exercise was not altered by intrauterine malnutrition or a fructose-rich diet, although the high fructose intake after the balanced diet in utero increased blood lactate during swimming exercises in rats.
Cambri
Lucieli Teresa
LT
Department of Physical Education, São Paulo State University (UNESP), Rio Claro-SP, Brazil. lucambri@yahoo.com.br
Dalia
Rodrigo Augusto
RA
Ribeiro
Carla
C
Rostom de Mello
Maria Alice
MA
D000367:Age Factors; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D018753:Diet, Protein-Restricted / Q000009:adverse effects*; D004044:Dietary Proteins / Q000097:blood; D019422:Dietary Sucrose / Q000008:administration & dosage*; D004195:Disease Models, Animal; D017079:Exercise Tolerance; D005260:Female; D048070:Fetal Nutrition Disorders / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D006003:Glycogen / Q000378:metabolism; D007700:Kinetics; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011502:Protein-Energy Malnutrition / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D012709:Serum Albumin / Q000378:metabolism; D013550:Swimming
D001786:Blood Glucose; D004044:Dietary Proteins; D019422:Dietary Sucrose; D012709:Serum Albumin; D019344:Lactic Acid; D006003:Glycogen