Investigation of neuronal progenitor cell origin after transient focal cerebral ischemia in mice.
Following cerebral ischemia both neuronal precursors and hematogenous cells migrate along chemokine gradients towards the injured tissue. Bone marrow derived cells are involved in the stroke related inflammatory and restaurative processes and newly born neurons are known to proliferate and migrate from the subventricular zone to the ischemic lesion. In the present study, we investigated whether hematogenous cells contribute to subpopulations of neuronal precursors using green fluorescent protein-transgenic bone marrow chimeric mice. In our experiments we found no blood-borne neuronal precursors within the ischemic site indicating that detected neuronal progenitor cells are only of brain parenchymal origin.
Strecker
Jan-Kolja
JK
Department of Neurology, University Hospital Münster, D-48129 Münster, Germany. strecker.jan@gmx.de
Minnerup
Jens
J
Sevimli
Sevgi
S
Ringelstein
E Bernd
EB
Schäbitz
Wolf-Rüdiger
WR
Schilling
Matthias
M
D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002465:Cell Movement; D049109:Cell Proliferation; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D058953:Neural Stem Cells; D009474:Neurons / Q000473:pathology