Integrative responses to high pH stress in S. cerevisiae.
The budding yeast Saccharomyces cerevisiae grows far better at acidic than at neutral or alkaline pH. Consequently, even a modest alkalinization of the medium represents a stressful situation for this yeast. In the past few years, data generated by a combination of genome-wide techniques has demonstrated that adaptive responses of S. cerevisiae to high pH stress involves extensive gene remodeling as a result of the fast activation of a number of stress-related signaling pathways, such as the Rim101, the Wsc1-Pkc1-Slt2 MAP kinase, and the calcium-activated calcineurin pathways. Alkalinization of the environment also disturbs nutrient homeostasis, as deduced from its impact on iron/copper, phosphate, and glucose uptake/utilization pathways. In this review we will examine these responses, their possible interactions, and the role that they play in tolerance to high pH stress.
Ariño
Joaquín
J
Departament de Bioquímica i Biologia Molecular & Institut de Biotecnologia i Biomedicina, Universitat Autónoma de Barcelona, Barcelona, Spain. Joaquin.Arino@uab.es
D019703:Calcineurin / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006706:Homeostasis; D006863:Hydrogen-Ion Concentration; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological
D029701:Saccharomyces cerevisiae Proteins; D019703:Calcineurin