Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic.
Chemical profiling of a Streptomyces griseus strain isolated from an old building with moisture damage led to the discovery of two novel phenoxazinones, chandrananimycin D and pitucamycin , along with the known grixazone B. Pitucamycin represents an unprecedented hybrid molecule composed of a phenoxazinone and an enaminomycin-like epoxyquinone moiety.
Gomes
Patrícia Bezerra
PB
Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse, 07745 Jena, Germany.
Nett
Markus
M
Dahse
Hans-Martin
HM
Hertweck
Christian
C
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001487:Basidiomycota / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D009161:Mycobacterium / Q000187:drug effects; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010408:Penicillium chrysogenum / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013305:Streptomyces griseus / Q000737:chemistry*
C485864:1-((2-(acetylamino)-2-carboxyethyl)thio)-2-amino-3-oxo-8-carboxyl-3H-phenoxiazine; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010078:Oxazines; C552904:chandrananimycin D; C552905:pitucamycin; C020456:phenoxazinone