title: HDM2 ERKs PCNA.
abstract: In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability and is associated with cell transformation.
authors: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
authors: Hai Dang
authors: HD
authors: Nguyen
authors: Anja-Katrin
authors: AK
authors: Bielinsky
mesh_terms: D002471:Cell Transformation, Neoplastic; D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D011485:Protein Binding; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*
chemical_list: D002843:Chromatin; D018809:Proliferating Cell Nuclear Antigen; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D048049:Extracellular Signal-Regulated MAP Kinases; C456320:MAPK15 protein, human