Core-shell La(1-x)Sr(x)MnO3 nanoparticles as colloidal mediators for magnetic fluid hyperthermia.
Core-shell nanoparticles consisting of La(0.75)Sr(0.25)MnO(3) cores covered by silica were synthesized by a procedure consisting of several steps, including the sol-gel method in the presence of citric acid and ethylene glycol, thermal and mechanical treatment, encapsulation employing tetraethoxysilane and final separation by centrifugation in order to get the required size fraction. Morphological studies revealed well-separated particles that form a stable water suspension. Magnetic studies include magnetization measurements and investigation of the ferromagnetic-superparamagnetic-paramagnetic transition. Magnetic heating experiments in 'calorimetric mode' were used to determine the heating efficiency of the particles in water suspension and further employed for biological studies of extracellular and intracellular effects analysed by tests of viability.
Pollert
E
E
Institute of Physics, Academy of Sciences of the Czech Republic, v.v.i., Cukrovarnická 10, 162 53 Prague 6, Czech Republic. pollert@fzu.cz
Kaman
O
O
Veverka
P
P
Veverka
M
M
Marysko
M
M
Záveta
K
K
Kacenka
M
M
Lukes
I
I
Jendelová
P
P
Kaspar
P
P
Burian
M
M
Herynek
V
V
D000818:Animals; D003102:Colloids; D019793:Fluorescein; D005456:Fluorescent Dyes; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D066298:In Vitro Techniques; D007811:Lanthanum; D055909:Magnetic Field Therapy / Q000295:instrumentation / Q000379:methods; D008280:Magnetics; D017895:Manganese Compounds; D059630:Mesenchymal Stem Cells / Q000502:physiology / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010087:Oxides; D010316:Particle Size; D051381:Rats; D013324:Strontium
D003102:Colloids; D005456:Fluorescent Dyes; D017895:Manganese Compounds; D010087:Oxides; C027424:manganese oxide; D007811:Lanthanum; D019793:Fluorescein; D013324:Strontium