title: Advanced antisense therapies for postexposure protection against lethal filovirus infections.
abstract: Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30-60 min after infection, protects>60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection. PMOplus may be useful for treating these and other highly pathogenic viruses in humans.
authors: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
authors: Travis K
authors: TK
authors: Warren
authors: Kelly L
authors: KL
authors: Warfield
authors: Jay
authors: J
authors: Wells
authors: Dana L
authors: DL
authors: Swenson
authors: Kelly S
authors: KS
authors: Donner
authors: Sean A
authors: SA
authors: Van Tongeren
authors: Nicole L
authors: NL
authors: Garza
authors: Lian
authors: L
authors: Dong
authors: Dan V
authors: DV
authors: Mourich
authors: Stacy
authors: S
authors: Crumley
authors: Donald K
authors: DK
authors: Nichols
authors: Patrick L
authors: PL
authors: Iversen
authors: Sina
authors: S
authors: Bavari
mesh_terms: D000818:Animals; D029043:Ebolavirus / Q000302:isolation & purification; D018702:Filoviridae Infections / Q000235:genetics* / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D019142:Hemorrhagic Fever, Ebola / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D008253:Macaca mulatta / Q000276:immunology; D008379:Marburg Virus Disease / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D029024:Marburgvirus / Q000302:isolation & purification; D011323:Primates; D012449:Safety; D014614:Vaccines, Synthetic / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D014614:Vaccines, Synthetic; D014765:Viral Vaccines