title: [Apoptosis effects on human esophageal cancer cells by soyasaponin Bb and its machanism].
abstract: OBJECTIVE
  To explore the effect and potential mechanism of apoptosis in the Eca-9706 cells induced by soyasaponin Bb.
  
  
  METHODS
  Different concentrations of soyasaponin Bb were on the Eca-9706 cell. Cell growth suppression rate was detected by MTT. Apoptotic rate was detected by TUNEL. The expression changes of HDAC1, NF-kappaB, PTEN, cyclin D1, c-met, VEGF or caspase-3 in the SSBb were detected by immunohistochemistry and immunoblotting.
  
  
  RESULTS
  Compared with the control group, the growth-inhibition rate and apoptotic rate were increased, the expressions of PTEN, caspase 3 were increased, the expressions of c-met, VEGF, HDAC1, NF-kappaB and cyclin D1 were decreased.
  
  
  CONCLUSIONS
  SSBb can suppress Eca-9706 cell growth. SSBb can exhibit reverse effects on over expression of c-met, VEGF in Eca-9706 cells. Eca-9706 cell apoptosis can be induced by SSBb through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways.
authors: College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors: Yingxin
authors: Y
authors: Pei
authors: Huanhuan
authors: H
authors: Zhao
authors: Xiaoyan
authors: X
authors: Du
authors: Jinping
authors: J
authors: Li
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004938:Esophageal Neoplasms / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D012503:Saponins / Q000494:pharmacology*
chemical_list: D012503:Saponins; C089346:soyasaponin beta g; C407096:soyasapogenol B; D009828:Oleanolic Acid