Bench-to-bedside review: Glucose and stress conditions in the intensive care unit.
The physiological response to blood glucose elevation is the pancreatic release of insulin, which blocks hepatic glucose production and release, and stimulates glucose uptake and storage in insulin-dependent tissues. When this first regulatory level is overwhelmed (that is, by exogenous glucose supplementation), persistent hyperglycaemia occurs with intricate consequences related to the glucose acting as a metabolic substrate and as an intracellular mediator. It is thus very important to unravel the glucose metabolic pathways that come into play during stress as well as the consequences of these on cellular functions. During acute injuries, activation of serial hormonal and humoral responses inducing hyperglycaemia is called the 'stress response'. Central activation of the nervous system and of the neuroendocrine axes is involved, releasing hormones that in most cases act to worsen the hyperglycaemia. These hormones in turn induce profound modifications of the inflammatory response, such as cytokine and mediator profiles. The hallmarks of stress-induced hyperglycaemia include 'insulin resistance' associated with an increase in hepatic glucose output and insufficient release of insulin with regard to glycaemia. Although both acute and chronic hyperglycaemia may induce deleterious effects on cells and organs, the initial acute endogenous hyperglycaemia appears to be adaptive. This acute hyperglycaemia participates in the maintenance of an adequate inflammatory response and consequently should not be treated aggressively. Hyperglycaemia induced by an exogenous glucose supply may, in turn, amplify the inflammatory response such that it becomes a disproportionate response. Since chronic exposure to glucose metabolites, as encountered in diabetes, induces adverse effects, the proper roles of these metabolites during acute conditions need further elucidation.
Losser
Marie-Reine
MR
Laboratoire de Recherche Paris 7 EA 3509, Service d'Anesthésie-Réanimation, Hôpital Lariboisière, Assistance Publique - Hôpitaux de Paris, Université Diderot Paris-7, 75475 Paris Cedex 10, France. mariereine.losser@sfr.fr
Damoisel
Charles
C
Payen
Didier
D
D001786:Blood Glucose / Q000032:analysis / Q000502:physiology; D016638:Critical Illness; D005947:Glucose / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D000860:Hypoxia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D007362:Intensive Care Units; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism / Q000503:physiopathology; D013312:Stress, Physiological / Q000502:physiology; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*
D001786:Blood Glucose; D017382:Reactive Oxygen Species; D005947:Glucose