Asymmetric transfer hydrogenation of ketones catalyzed by rhodium complexes containing amino acid triazole ligands.
Active and selective catalysts for the asymmetric reduction of ketones, under transfer hydrogenation conditions, were obtained by combining [RhCl(2)Cp*](2), with a series of l-amino acid thioamide ligands functionalized with 1,2,3-triazoles. The obtained secondary alcohol products were formed with up to 93% ee.
Tinnis
Fredrik
F
Department of Organic Chemistry, Stockholm University, The Arrhenius Laboratory, SE-10691 Stockholm, Sweden.
Adolfsson
Hans
H
D002384:Catalysis; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
D007659:Ketones; D008024:Ligands; D014230:Triazoles; D012238:Rhodium