title: Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats.
abstract: Cerebrovascular changes following status epilepticus (SE) are not well understood, yet they may contribute to epileptogenesis. We studied hemodynamic changes in the cerebral cortex and amygdala by arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) MRI at 2 days and 14 days after pilocarpine-induced SE in rats. There were no cortical hemodynamic changes, yet in the amygdala we found prolonged elevation in cerebral blood flow (CBF, 129% of control mean, day 14, p<0.01). There was a trend towards increased cerebral blood volume (CBV) during the same imaging sessions. Through immunohistochemistry, we observed increased vessel density in the amygdala (127% of control mean, day 14, p<0.05). In conclusion, epileptogenesis may involve hemodynamic changes that are associated with vascular reorganization during post-SE remodeling in the amygdaloid complex.
authors: Department of Neurobiology, Biomedical NMR Group, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FIN-70211, Kuopio, Finland.
authors: Nick M E A
authors: NM
authors: Hayward
authors: Xavier Ekolle
authors: XE
authors: Ndode-Ekane
authors: Nino
authors: N
authors: Kutchiashvili
authors: Olli
authors: O
authors: Gröhn
authors: Asla
authors: A
authors: Pitkänen
mesh_terms: D000679:Amygdala / Q000098:blood supply* / Q000503:physiopathology; D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006439:Hemodynamics; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D010862:Pilocarpine; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D010862:Pilocarpine