Mouse phenotyping.
Model organisms like the mouse are important tools to learn more about gene function in man. Within the last 20 years many mutant mouse lines have been generated by different methods such as ENU mutagenesis, constitutive and conditional knock-out approaches, knock-down, introduction of human genes, and knock-in techniques, thus creating models which mimic human conditions. Due to pleiotropic effects, one gene may have different functions in different organ systems or time points during development. Therefore mutant mouse lines have to be phenotyped comprehensively in a highly standardized manner to enable the detection of phenotypes which might otherwise remain hidden. The German Mouse Clinic (GMC) has been established at the Helmholtz Zentrum München as a phenotyping platform with open access to the scientific community (www.mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2]).
Fuchs
Helmut
H
Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 München/Neuherberg, Germany.
Gailus-Durner
Valérie
V
Adler
Thure
T
Aguilar-Pimentel
Juan Antonio
JA
Becker
Lore
L
Calzada-Wack
Julia
J
Da Silva-Buttkus
Patricia
P
Neff
Frauke
F
Götz
Alexander
A
Hans
Wolfgang
W
Hölter
Sabine M
SM
Horsch
Marion
M
Kastenmüller
Gabi
G
Kemter
Elisabeth
E
Lengger
Christoph
C
Maier
Holger
H
Matloka
Mikolaj
M
Möller
Gabriele
G
Naton
Beatrix
B
Prehn
Cornelia
C
Puk
Oliver
O
Rácz
Ildikó
I
Rathkolb
Birgit
B
Römisch-Margl
Werner
W
Rozman
Jan
J
Wang-Sattler
Rui
R
Schrewe
Anja
A
Stöger
Claudia
C
Tost
Monica
M
Adamski
Jerzy
J
Aigner
Bernhard
B
Beckers
Johannes
J
Behrendt
Heidrun
H
Busch
Dirk H
DH
Esposito
Irene
I
Graw
Jochen
J
Illig
Thomas
T
Ivandic
Boris
B
Klingenspor
Martin
M
Klopstock
Thomas
T
Kremmer
Elisabeth
E
Mempel
Martin
M
Neschen
Susanne
S
Ollert
Markus
M
Schulz
Holger
H
Suhre
Karsten
K
Wolf
Eckhard
E
Wurst
Wolfgang
W
Zimmer
Andreas
A
Hrabě de Angelis
Martin
M
D000818:Animals; D001522:Behavior, Animal; D001774:Blood Chemical Analysis / Q000379:methods; D002386:Cataract / Q000473:pathology; D007677:Kidney Function Tests / Q000379:methods; D051379:Mice; D008817:Mice, Mutant Strains; D008818:Mice, Neurologic Mutants; D016296:Mutagenesis; D010147:Pain Measurement / Q000379:methods / Q000592:standards; D010641:Phenotype; D012015:Reference Standards; D016482:Urinalysis / Q000379:methods