KMnO(4)-Mediated oxidation as a continuous flow process.
An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant within a continuous flow reactor is reported. Notably, the generation and downstream processing of MnO(2) slurries was not found to cause any blocking of the reactor when ultrasound pulses were applied to the flow system.
Sedelmeier
Jörg
J
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Ley
Steven V
SV
Baxendale
Ian R
IR
Baumann
Marcus
M
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000473:Alkanes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D011196:Potassium Permanganate / Q000737:chemistry*
D000438:Alcohols; D000447:Aldehydes; D000473:Alkanes; D002264:Carboxylic Acids; D009574:Nitro Compounds; D011196:Potassium Permanganate