title: Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands.
abstract: Isosteric replacement of the amide function and modulation of the arylpiperazine moiety of known dopamine D3 receptor ligands led to potent and selective compounds. Enhanced bioavailability and preferential brain distribution make compound 6c a good candidate for pharmacological and clinical evaluation.
authors: UPRES EA 4090, Substances Lichéniques et Photoprotection, Université de Rennes I, Faculté des Sciences Biologiques et Médicales, 2, Av. du Pr. Léon Bernard, 35043 Rennes, France.
authors: Mickaël
authors: M
authors: Jean
authors: Jacques
authors: J
authors: Renault
authors: Nicolas
authors: N
authors: Levoin
authors: Denis
authors: D
authors: Danvy
authors: Thierry
authors: T
authors: Calmels
authors: Isabelle
authors: I
authors: Berrebi-Bertrand
authors: Philippe
authors: P
authors: Robert
authors: J C
authors: JC
authors: Schwartz
authors: J M
authors: JM
authors: Lecomte
authors: Philippe
authors: P
authors: Uriac
authors: Marc
authors: M
authors: Capet
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D000077489:Piperazine; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D050637:Receptors, Dopamine D3 / Q000378:metabolism*
chemical_list: D000577:Amides; D008024:Ligands; D010879:Piperazines; D050637:Receptors, Dopamine D3; D000077489:Piperazine