title: Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni.
abstract: The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.
authors: Laboratório de Imunologia Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors: Denise
authors: D
authors: Silveira-Lemos
authors: Andréa
authors: A
authors: Teixeira-Carvalho
authors: Olindo Assis
authors: OA
authors: Martins-Filho
authors: Adriano Luiz
authors: AL
authors: Souza-Soares
authors: Pollyanna
authors: P
authors: Castro-Silva
authors: Matheus Fernandes
authors: MF
authors: Costa-Silva
authors: Pedro Henrique Gazzinelli
authors: PH
authors: Guimarães
authors: Helena Barbosa
authors: HB
authors: Ferraz
authors: Lúcia Alves
authors: LA
authors: Oliveira-Fraga
authors: Mauro Martins
authors: MM
authors: Teixeira
authors: Rodrigo
authors: R
authors: Corrêa-Oliveira
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000909:Antibodies, Helminth / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood* / Q000276:immunology; D004804:Eosinophils / Q000737:chemistry* / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D019707:Receptors, Chemokine / Q000097:blood* / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology*; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D000911:Antibodies, Monoclonal; D018925:Chemokines; D019707:Receptors, Chemokine