title: Measurement of the linear attenuation coefficients of breast tissues by synchrotron radiation computed tomography.
abstract: The measurement of the linear attenuation coefficients of breast tissues is of fundamental importance in the field of breast x-ray diagnostic imaging. Different groups have evaluated the linear attenuation coefficients of breast tissues by carrying out direct attenuation measurements in which the specimens were thin and selected as homogeneous as possible. Here, we use monochromatic and high-intensity synchrotron radiation computed tomography (SR CT) to evaluate the linear attenuation coefficients of surgical breast tissues in the energy range from 15 to 26.5 keV. X-ray detection is performed by a custom digital silicon micro-strip device, developed in the framework of the PICASSO INFN experiment. Twenty-three human surgical breast samples were selected for SR CT and histological study. Six of them underwent CT, both as fresh tissue and after formalin fixation, while the remaining 17 were imaged only as formalin-fixed tissues. Our results for fat and fibrous tissues are in good agreement with the published values. However, in contrast to the published data, our measurements show no significant differences between fibrous and tumor tissues. Moreover, our results for fresh and formalin-fixed tissues demonstrate a reduction of the linear attenuation coefficient for fibrous and tumor tissues after fixation.
authors: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China. rongchang.chen@gmail.com
authors: R C
authors: RC
authors: Chen
authors: R
authors: R
authors: Longo
authors: L
authors: L
authors: Rigon
authors: F
authors: F
authors: Zanconati
authors: A
authors: A
authors: De Pellegrin
authors: F
authors: F
authors: Arfelli
authors: D
authors: D
authors: Dreossi
authors: R-H
authors: RH
authors: Menk
authors: E
authors: E
authors: Vallazza
authors: T Q
authors: TQ
authors: Xiao
authors: E
authors: E
authors: Castelli
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D003238:Connective Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D004735:Energy Transfer; D005260:Female; D006801:Humans; D016014:Linear Models; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*