title: Human brucellosis in Macedonia - 10 years of clinical experience in endemic region.
abstract: OBJECTIVE
  To present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia.
  
  
  METHODS
  A total of 550 patients with brucellosis treated between 1998 and 2007 were retrospectively assessed for their demographic, epidemiological, and clinical characteristics and outcomes.
  
  
  RESULTS
  Of the 550 patients, 395 (72%) were male. The median age was 34.5 years (range, 1-82). Direct contact with infected animals was recorded in 333 (61%) patients and positive family history in 310 (56%). The most frequently seen symptoms were arthralgia (438, 80%), fever (419, 76%), and sweating (394, 72%). The most common signs were fever and hepatomegaly, which were verified in 357 (65%) and 273 (50%) patients, respectively. Focal brucellosis was found in 362 patients (66%) and osteoarticular in 299 (54%). Therapeutic failures were registered in 37 (6.7%) patients. Of the 453 (82%) patients who completed a follow-up period of at least 6 months, relapses occurred in 60 (13%).
  
  
  CONCLUSIONS
  Due to non-specific clinical manifestation and laboratory parameters, brucellosis should be considered one of the differential diagnoses of any patient suffering from obscure involvement of various organs in a brucellosis-endemic region. High percentage of relapses and therapeutic failures in spite of the use of currently recommended therapeutic regimens indicates the seriousness of this zoonosis and the need to control it.
authors: University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia. milebos@yahoo.com
authors: Mile
authors: M
authors: Bosilkovski
authors: Ljiljana
authors: L
authors: Krteva
authors: Marija
authors: M
authors: Dimzova
authors: Ivan
authors: I
authors: Vidinic
authors: Zaklina
authors: Z
authors: Sopova
authors: Katerina
authors: K
authors: Spasovska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000175:diagnosis / Q000453:epidemiology; D002006:Brucellosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D005260:Female; D005334:Fever; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D018843:Republic of North Macedonia / Q000453:epidemiology; D012189:Retrospective Studies; D013546:Sweating; D013997:Time Factors; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D055815:Young Adult; D015047:Zoonoses
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination