title: [Analysis on epidemiological and serum effect after vaccination of hepatitis A vaccine (HepA)].
abstract: OBJECTIVE
  To implement HepA vaccination and analyze epidemiological and serum effect.
  
  
  METHODS
  The children from 1 to 14 years old were vaccinated HepA since 1992 and the HepA has been integrated into EPI to the children aged 1 year in 1996. The enzyme linked immunnosortbent assay (ELISA) was used to detect Anti-Hepatitis A Virus IgG Antibody (Anti-HAV) to analyze serum effect.
  
  
  RESULTS
  HepA coverage rate from 1 to 14 years old was 80% in 1998, and it was > 90% after the year of 2001. The coverage of 1 year old children was 95%. The incidence rate of Hepatitis A reduced continuously. The incidence of whole population reduced from 25.96/100.000 in 1992 to 6.38/100.000 in 1994. In 2007, the incidence of Heptitis A decreased 98.10% compared with the incidence of the year of 1992. Epidemiological feature of Hepatitis A was changed. The positive rate of Anti-HAV was increased after vaccination of Hepatitis A Vaccine.
  
  
  CONCLUSIONS
  The vaccination strategy for 1 to 14 years old had obviously epidemiological and serum effect.
authors: Weifang Prefecture Centre for Disease Control and Prevention, Weifang 261041, Shandong, China.
authors: Jian-ping
authors: JP
authors: Li
authors: Zhi-xia
authors: ZX
authors: Gao
authors: Jian
authors: J
authors: Zhou
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006506:Hepatitis A / Q000097:blood* / Q000453:epidemiology* / Q000517:prevention & control; D035922:Hepatitis A Antibodies / Q000097:blood* / Q000276:immunology; D022362:Hepatitis A Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D014611:Vaccination
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines