HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging.
We report in this Communication a facile, two-step surface modification strategy to achieve manganese oxide nanoparticles with prominent MRI T1 contrast. In a U87MG glioblastoma xenograft model, we confirmed that the particles can accumulate efficiently in tumor area to induce effective T1 signal alteration.
Huang
Jing
J
Department of Radiology and Bio-X Program, Stanford University, 1201 Welch Road P087, Stanford, CA 94305, USA.
Xie
Jin
J
Chen
Kai
K
Bu
Lihong
L
Lee
Seulki
S
Cheng
Zhen
Z
Li
Xingguo
X
Chen
Xiaoyuan
X
D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D003301:Copper Radioisotopes; D006801:Humans; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010087:Oxides / Q000737:chemistry*; D049268:Positron-Emission Tomography; D012709:Serum Albumin / Q000737:chemistry*; D014183:Transplantation, Heterologous
D003287:Contrast Media; D003301:Copper Radioisotopes; D017895:Manganese Compounds; D010087:Oxides; D012709:Serum Albumin; C027424:manganese oxide