title: Hepatic and biliary damage after transarterial chemoembolization for malignant hepatic tumors: incidence, diagnosis, treatment, outcome and mechanism.
abstract: OBJECTIVE
  To provide an overview of recent studies on transarterial chemoembolization-related hepatic and biliary damage (TRHBD) in patients with malignant hepatic tumors (MHT) and to explore the reasons for TRHBD.
  
  
  METHODS
  Literature on the treatments for MHT by TACE was sought in PubMed and the related information was summarized.
  
  
  RESULTS
  TRHBD is found to occur in the hepatic parenchymal cells, biliary tree and blood-vascular system. The damage is mainly due to ischemia resulting from embolic materials such as gelatin sponge and lipiodol. In addition, clinicians' skill levels in non-superselective catheterization, the health condition of the patients, and the chemical agents used may also be related to the damage. Most of the deterioration can be reversed if the patients are diagnosed and treated properly and promptly.
  
  
  CONCLUSIONS
  Understanding the mechanisms of TRHBD more comprehensively is helpful in developing effective methods for prevention and treatment.
authors: Department of Hepatobiliary Surgery, Jingzhou Central Hospital, JingZhou 4343100, Hubei Province, China.
authors: Zhengang
authors: Z
authors: Sun
authors: Gaopeng
authors: G
authors: Li
authors: Xi
authors: X
authors: Ai
authors: Baoming
authors: B
authors: Luo
authors: Yanling
authors: Y
authors: Wen
authors: Zizhuo
authors: Z
authors: Zhao
authors: Shengli
authors: S
authors: Dong
authors: Jian
authors: J
authors: Guan
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001659:Biliary Tract / Q000098:blood supply / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects* / Q000379:methods; D002764:Cholecystitis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D016206:Databases, Bibliographic; D004322:Drainage / Q000379:methods; D004998:Ethiodized Oil / Q000009:adverse effects; D005781:Gelatin Sponge, Absorbable / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008100:Liver Abscess / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000098:blood supply / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D008297:Male; D009336:Necrosis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004998:Ethiodized Oil