The Immunoproteasome Cleans up after Inflammation.
Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse models of inflammatory disease that immunoproteasomes help prevent the accumulation of harmful protein aggregates.
van Deventer
Sjoerd
S
The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Neefjes
Jacques
J