Complement-dependent transport of antigen into B cell follicles.
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.
Gonzalez
Santiago F
SF
The Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.
Lukacs-Kornek
Veronika
V
Kuligowski
Michael P
MP
Pitcher
Lisa A
LA
Degn
Søren E
SE
Turley
Shannon J
SJ
Carroll
Michael C
MC
D000818:Animals; D000941:Antigens / Q000378:metabolism*; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism* / Q000821:virology; D002451:Cell Compartmentation / Q000276:immunology; D003165:Complement System Proteins / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000821:virology; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D021381:Protein Transport / Q000276:immunology
D000941:Antigens; D003165:Complement System Proteins