[Nonspecific adaptation reactions and immunological status in patients with type 2 diabetes mellitus].
The clinical laboratory study of 75 patients with type 2 diabetes mellitus (T2D) has shown that most of them have elevated immunoglobulin A and G levels, the diminished activity of neutrophiles, and higher C-reactive protein and 30% of the patients show non-physiological adaptation reactions: reactivation and stress. During these reactions, there are the most pronounced changes in the immunological status and in the level of acute phase protein. The rate of nonphysiological reactions increases, immunity deteriorates, and the activity of an inflammatory process is enhanced with the longer duration of T2D, grades 2 and 3 arterial hypertension, micro- and macroangiopathies, as well as with more evident hyperglycemia and triglyceridemia.
Beliakova
N A
NA
Mikhaĭlova
D G
DG
Egorova
E N
EN
Gogina
E D
ED
Gorshkova
M A
MA
D000209:Acute-Phase Proteins / Q000032:analysis; D000222:Adaptation, Physiological; D002097:C-Reactive Protein / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000276:immunology; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D013312:Stress, Physiological
D000209:Acute-Phase Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D002097:C-Reactive Protein