title: N,O-diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents.
abstract: Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.
authors: Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India.
authors: Nilanjana
authors: N
authors: Chowdhury
authors: Sansa
authors: S
authors: Dutta
authors: Boda
authors: B
authors: Nishitha
authors: Swagata
authors: S
authors: Dasgupta
authors: N D Pradeep
authors: ND
authors: Singh
mesh_terms: D053837:DNA Cleavage / Q000528:radiation effects; D004270:DNA, Circular / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry* / Q000494:pharmacology*; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D004270:DNA, Circular; D006898:Hydroxylamines; D017319:Photosensitizing Agents; C012484:phenylhydroxylamine