Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives.
With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.
Pedgaonkar
Yogesh Y
YY
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai, 400019, India.
Degani
Mariam S
MS
Iyer
Radhakrishnan P
RP
D000178:Acrylamides / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D005561:Formates / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010705:Phosgene / Q000031:analogs & derivatives / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D000178:Acrylamides; D000588:Amines; D005561:Formates; D009570:Nitriles; C030544:formic acid; D010705:Phosgene; C111044:bis(trichloromethyl) carbonate; D014498:Uracil; C031594:2-cyanoacetamide