Losartan associated anaphylaxis and angioneurotic oedema.
A case of anaphylaxis and angioedema induced by angiotensin II receptor blocker (ARB), losartan is reported. A 37 years old hypertensive female presented to the Emergency Department with swelling over the face especially the lips, urticarial rash all over the body, and dyspnoea within an hour of losartan administration. She did not have any previous history of drug allergies. The patient was managed with epinephrine. Although angioneurotic oedema and anaphylaxis are well documented adverse effects of angiotensin converting enzyme (ACE) inhibitors, very few cases of these adverse reactions with ARBs have been reported in medical literature.
Kazim
Syed Faraz
SF
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
Shahid
Muhammad
M
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D000799:Angioedema / Q000139:chemically induced* / Q000188:drug therapy; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D019808:Losartan; D004837:Epinephrine