[Analgesic effects and mechanism of Yuanhuzhentong capsule].
OBJECTIVE
To study the analgesic effects and mechanism of Yuanhuzhentong capsule.


METHODS
The rats trigeminal nerve headache model, the migraine model caused by nitroglycerim, and the mice hot plate test. The rat formalin test were used to evaluate the analgesic effects. The effects on mice automative activities, the content of monoamine neurotansmitters in rats trigeminal nerve headache model and the hemorrheology in model of blood stasis were investigated to analyze the analgesic effects.


RESULTS
Yuanhuzhentong capsule can prolong the latency of the rats trigeminal nerve headache model and reduce the durante dolors. It can relieve the reaction caused by nitroglycerim in different times and increase the threshold in mice hot plate test. It can decrease obviously the response time of the chronicity pain model rat caused by formalin in second phase and also decrease the counts of automative activities in 5 min. It can increase the content of 5-HT and decrease blood viscosity in blood stasis model rats.


CONCLUSIONS
The results indicated that Yuanhuzhentong capsule has obvious analgesic effects, and the mechanism concernes with the sedation, adjusting the secretion of NT in brain and improving the blood circulation.
Li
Na
N
Department of Drug Safety Evaluation Center, Beijing Institute for Drug Control, Beijing 100035, China. lina3_3@126.com
Jin
Cuiying
C
Zhou
Jianping
J
Hu
Yuchi
Y
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D002214:Capsules; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006261:Headache / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D002214:Capsules; D004365:Drugs, Chinese Herbal