Targeting protein-protein interactions: a promising avenue of anti-HIV drug discovery.
In recent years, the number of useful chemical biology information of protein-protein interactions in the HIV life cycle and related inhibitors, is growing rapidly, which makes protein-protein interactions a new investigative area for antiviral drug intervention. This review will summarize recent work in this field, mainly focusing on the utilization of small molecules targeted against a variety of protein-protein interactions that have great therapeutic feasibility for HIV infection, and lastly outline some other important protein-protein interactions with a potential to advance into novel anti-HIV drug targets in future.
Zhan
P
P
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China.
Li
W
W
Chen
H
H
Liu
X
X
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000627:therapeutic use; D015704:CD4 Antigens / Q000737:chemistry / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D023581:HIV Fusion Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D016333:HIV Protease / Q000737:chemistry / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D011485:Protein Binding; D054325:vpr Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors / Q000378:metabolism
D019380:Anti-HIV Agents; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D023581:HIV Fusion Inhibitors; D019428:HIV Integrase Inhibitors; D017320:HIV Protease Inhibitors; C514793:gp120 protein, Human immunodeficiency virus 1; D054325:vpr Gene Products, Human Immunodeficiency Virus; C514912:vpr protein, Human immunodeficiency virus 1; D019427:HIV Integrase; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1