[Relationship between hepatitis B virus DNA and hepatitis B virus large envelope protein].
To investigate the relationship between HBV DNA and hepatitis B virus large envelope protein (HBV-LP) in patients with chronic hepatitis B.



Serum HBV DNA was detected by RT-PCR and the HBV-LP was detected by enzyme linked immunosorbent assay in 320 serum samples collected from patients with chronic hepatitis B.



There were no significant difference between positive rate of HBV-LP and that of HBV DNA in different HBeAg patterns (P>0.05). Serum HBV-LP levels were closely correlated with HBV DNA copies (r=0.949).



Serum HBV-LP is a reliable serological marker that can reflect the replication of HBV.
Wen
Huai-kai
HK
Laboratory Diagnosis Center, The Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, China. whk@wzhealth.com
Yu
Jian
J
Li
Xiao-yong
XY
Tao
Hong-qun
HQ
Zhang
Xin-liang
XL
D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014759:Viral Envelope Proteins / Q000097:blood*; D014779:Virus Replication; D055815:Young Adult
D004279:DNA, Viral; C096362:L protein, hepatitis B virus; D014759:Viral Envelope Proteins