title: Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes.
abstract: Tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro. Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. The present study was aimed to evaluate possible antihypertensive effect of IPP and VPP in this severe model. Four-week-old dTGR were randomized in three groups to receive: (1) water (control), (2) fermented milk containing IPP and VPP, and (3) IPP and VPP dissolved in water for three weeks. Fermented milk, but not peptides in water, attenuated the development of hypertension in dTGR by 19 mmHg versus the control group (P = .023). In vitro vascular function tests showed that high concentrations of the peptides evinced ACE inhibitory properties. In other hypertension related variables, no significant differences between the treatment groups were found. In conclusion, fermented milk product containing IPP and VPP prevents development of malignant hypertension in an animal model.
authors: Institute of Biomedicine, Pharmacology, University of Helsinki, 00014 Helsinki, Finland.
authors: Tiina
authors: T
authors: Jauhiainen
authors: Taru
authors: T
authors: Pilvi
authors: Zhong Jian
authors: ZJ
authors: Cheng
authors: Hannu
authors: H
authors: Kautiainen
authors: Dominik N
authors: DN
authors: Müller
authors: Heikki
authors: H
authors: Vapaatalo
authors: Riitta
authors: R
authors: Korpela
authors: Eero
authors: E
authors: Mervaala