Tuning mTORC1 activity for balanced self-renewal and differentiation.
Understanding the mechanisms that control stem cell self-renewal and differentiation are at the core of stem cell biology. In a recent issue of Cell, Hobbs et al. report that harnessing mTORC1 activity by the transcription factor PLZF is crucial to maintain the self-renewing activity of germline progenitors.
Carnevalli
Larissa S
LS
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Trumpp
Andreas
A