[Study on the antigenicity and HA1 gene characteristics of influenza A viruses during 2004-2008 year in China].
OBJECTIVE
To under stand influenza A viruses epidemic, antigenicity and genetic characteristics variation between the vaccine and Circulation strains during 2004-2008 year in China.


METHODS
The influenza A viruses (H1N1, H3N2) isolated from 2004-2008 year were under took antigenic and sequence analysis. Influenza A virus antigenicity and genetic characteristics were analyzed thought amino acid variation compassion of HA1 protein of influenza A virus isolates.


RESULTS
The antigenicity of influenza H1N1 subtype viruses isolated from 2004 to 2007 is very similar with vaccine strain A/New Caledonia/20/1999 (HIN1)-like virus. The influenza H1N1 viruses circulated in 2008 year had similar antigenic characteristics with A/Brisben/59/2007 (H1N1) which is component of influenza vaccines for northern hemisphere 2008-2009 year. The influenza H3N2 subtype viruses of 2004-2005 year had antigenic variation comparatively with vaccine strain A/Fujian/411/12002 (H3N2), The antigenicity of 2006-2007 H3N2 viruses and 2008 year's is A/Wiscansin/67/2006(H3N2) and A/ Brisben/10/2006(H3N2) respectively.


CONCLUSIONS
There is change of influenza A viruses (H1N1, H3N2) antigenic and genetic characteristics during 2004-2008 in China.
Zhang
Ye
Y
State Key Laboratory for Viral Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing.
Zhao
Xiang
X
Huang
Wei-juan
WJ
Guo
Jun-feng
JF
Wei
He-jiang
HJ
Cheng
Yan-hui
YH
Li
Xin-wan
XW
Li
Xi-yan
XY
Guo
Yuan-ji
YJ
Shu
Yue-long
YL
D000595:Amino Acid Sequence; D000818:Animals; D000940:Antigenic Variation; D002460:Cell Line; D002681:China / Q000453:epidemiology; D004285:Dogs; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment
D019267:Hemagglutinin Glycoproteins, Influenza Virus