Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe.
This study aimed to compare the discrimination accuracy of hippocampal volume (HC-Vol), parahippocampal cingulum fractional anisotropy (PHC-FA), hippocampal glucose metabolism (HC-Glu), and any combination of the three measurements among normal control (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). Three-dimensional MRI, diffusion tensor imaging, and FDG-PET were applied to age- and gender-matched 17 NC, 17 MCI, and 17 mild AD patients. Subjects also underwent a neuropsychological test battery including three verbal episodic memory tests. Logistic regression analyses were systematically conducted to select the best model for between-group discrimination. PHC-FA plus HC-Vol model, HC-Glu only model, and the model combining all three modalities were finally chosen for NC vs. MCI (discrimination accuracy: 79.4%), MCI vs. AD (73.5%), and NC vs. AD discrimination (94.1%), respectively. All the three imaging measures also showed significant correlation with all three episodic memory tests. These findings support that each imaging measure, respectively, and their combination have a stage-specific potential as a useful neuroimaging marker for detection and progression monitoring of early stage of AD.
Jhoo
Jin Hyeong
JH
Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Lee
Dong Young
DY
Choo
Il Han
IH
Seo
Eun Hyun
EH
Oh
Jungsu S
JS
Lee
Jae Sung
JS
Lee
Dong Soo
DS
Kim
Shin Gyeom
SG
Youn
Jong Chul
JC
Kim
Ki Woong
KW
Woo
Jong Inn
JI
D000368:Aged; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D000704:Analysis of Variance; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography / Q000379:methods; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*