title: [Clinical Observation of Erlotinib as the First-line Treatment for Patients with Advanced Non-small Cell Lung Cancer.].
abstract: BACKGROUND
  To evaluate the efficacy and toxicity of erlotinib as the first-line therapy for advanced non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 28 pathologically-confirmed NSCLC patients who could not receive willingly or tolerate traditional cytotoxic drugs chemotherapy were enrolled. Erlotinib was orally administered 150 mg daily until disease progression or the occurrence of intolerable toxicity.
  
  
  RESULTS
  Among a total of 28 patients, the objective response rate (ORR) of erlotinib was 28.6%. The disease control rate (DCR) was 60.7%. The rate of symptom relief was 53.6%. The median progression free survival (PFS) was 3.2 (95%CI: 0.851-5.585) months. The median overall survival (OS) was 9.6 (95%CI: 7.179-12.021) months. One-year survival rate was 32.1%. The therapeutic effect was better in patients with rash. Most of the toxicities were grade I and grade II toxicity. The most common adverse events were rash (46.4%), diarrhea (32.1%), skin dry (25.0%), anorexia(17.9%), fatigue (10.7%) and increased transaminase (7.1%).
  
  
  CONCLUSIONS
  Erlotinib provided another choice for the patients who could not willingly receive or tolerate chemotherapy.
authors: Department of Medical Oncology, Fujian Provincial Tumor Hospital, Fujian Medical University Educational Hospital, Fuzhou 350014, China.
authors: Cheng
authors: C
authors: Huang
authors: Biao
authors: B
authors: Wu
authors: Wu
authors: W
authors: Zhuang
authors: Zhenwu
authors: Z
authors: Xn
authors: Jing
authors: J
authors: Zhang
authors: Yunjian
authors: Y
authors: Huang