Synthesis of novel naphthyl substituted fused indazolonols as potent anticandidal agents.
OBJECTIVE
A new series of naphthyl substituted indazolonols 15-21 were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1H, D2O exchanged 1H and 13C NMR spectroscopic data.


METHODS
All the synthesized compounds 15-21 were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis.


RESULTS
A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F, -Cl, Br and -NO2) functional group substituted phenyl rings of novel naphthyl substituted indazolonols 15-21 exerted strong anticandidal activity against all the tested Candida species.


CONCLUSIONS
Compounds 17, 19-21 exhibit MIC value in the range of 6.25-200 microg/mL against all the tested candida species.
Kanagarajan
V
V
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu, India.
Thanusu
J
J
Gopalakrishnan
M
M
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D006801:Humans; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods; D013329:Structure-Activity Relationship; D044366:Transition Temperature
D000935:Antifungal Agents; D007191:Indazoles; D009281:Naphthalenes