Functional MRI in chronic epilepsy: associations with cognitive impairment.
Chronic epilepsy is frequently accompanied by serious cognitive side-effects. Clinical factors are important, but cannot account entirely for this cognitive comorbidity. Therefore, research is focusing on the underlying cerebral mechanisms to understand the development of cognitive dysfunction. In the past two decades, functional MRI techniques have been applied extensively to the study of cognitive impairment in chronic epilepsy. However, because of wide variation in study designs, analysis methods, and data presentation, interpretation of these studies has become increasingly difficult for clinicians. In patients with localisation-related epilepsy, whether findings of functional MRI represent the underlying neuronal substrate for cognitive decline remains a subject of debate.
Vlooswijk
Marielle Cg
MC
Department of Neurology, Maastricht University Medical Centre, Maastricht, Netherlands.
Jansen
Jacobus Fa
JF
de Krom
Marc Cftm
MC
Majoie
Hj Marian
HM
Hofman
Paul Am
PA
Backes
Walter H
WH
Aldenkamp
Albert P
AP
D000818:Animals; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*