Challenges in clinical-pathologic correlations: acute tubular necrosis in a patient with collapsing focal and segmental glomerulosclerosis mimicking rapidly progressive glomerulonephritis.
Herein, we report a case of acute kidney injury (AKI) due to diarrhea-induced acute tubular necrosis (ATN) in a patient with nephrotic syndrome secondary to biopsy-proven collapsing focal and segmental glomerulosclerosis (FSGS). The clinical picture mimicked rapidly progressive glomerulonephritis (RPGN) and motivated pulse therapy with methylprednisolone and cyclophosphamide. The case presentation is followed by a brief overview of the epidemiology of AKI in nephrotic syndrome as well as a discussion of its risk factors and potential mechanisms involved.
Rodamilans
Mariana Freire
MF
Departamento de Medicina, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Barros
Luisa Leite
LL
Carneiro
Marcia M
MM
dos Santos
Washington Luis Conrado
WL
Rocha
Paulo Novis
PN
D003937:Diagnosis, Differential; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008875:Middle Aged