title: Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus: effects on gait in Parkinson's disease.
abstract: OBJECTIVE
  This study examines the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) and pedunculopontine tegmentum (PPTg) DBS in advanced Parkinson's disease using gait analysis.
  
  
  METHODS
  Five people underwent bilateral DBS in both the STN and PPTg. Gait analysis was performed one year after neurosurgery using an optoelectronic system. The effects of DBS (STN, PPTg and STN+PPTg) were studied in two clinical conditions: without (Off) and during (On) antiparkinsonian therapy.
  
  
  RESULTS
  PPTg and STN DBS were associated with changes in spatio-temporal and kinematics variables.
  
  
  CONCLUSIONS
  Although experimental data cannot be generalized widely due to the small sample, PPTg DBS appears to affect the neuronal circuits subserving gait.
authors: IRCCS, Santa Lucia Foundation, Via Ardeatina 309, 00179 Rome, Italy. a.peppe@hsantalucia.it
authors: A
authors: A
authors: Peppe
authors: M
authors: M
authors: Pierantozzi
authors: C
authors: C
authors: Chiavalon
authors: F
authors: F
authors: Marchetti
authors: C
authors: C
authors: Caltagirone
authors: M
authors: M
authors: Musicco
authors: P
authors: P
authors: Stanzione
authors: A
authors: A
authors: Stefani
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D046690:Deep Brain Stimulation; D005684:Gait / Q000502:physiology*; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy / Q000628:therapy*; D045042:Pedunculopontine Tegmental Nucleus / Q000601:surgery; D016059:Range of Motion, Articular; D020531:Subthalamic Nucleus / Q000601:surgery
chemical_list: D000978:Antiparkinson Agents