Use of chemoprotectants in chemotherapy and radiation therapy: the challenges of selecting an appropriate agent.
Chemoprotection refers to the protection from the toxicity of one chemical by the intervention of another. Conflicting preclinical and clinical reports make it difficult to either ignore or accept the use of chemoprotectants during cancer chemotherapy or radiotherapy. The selection of anticancer drugs depends on the type and stage of cancer development. However, very little attention has been paid to the selection of chemoprotectants. The answer to the use of chemoprotectants during cancer therapy lies in their appropriate selection in a case-specific and/or issue-specific manner. The need of the hour is to find better answers on the rationality of chemoprotectants selection during cancer therapy using cutting-edge science. In this commentary, we have presented few examples to justify our view-points.
Jena
Gopabandhu
G
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Mohali, Punjab, India. gbjena@gmail.com
Vikram
Ajit
A
Tripathi
Durga Nand
DN
Ramarao
Poduri
P
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D019587:Dietary Supplements; D006801:Humans; D009367:Neoplasm Staging; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D020011:Protective Agents / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents; D016032:Randomized Controlled Trials as Topic
D000970:Antineoplastic Agents; D000975:Antioxidants; D020011:Protective Agents; D011838:Radiation-Sensitizing Agents