title: Insights into the genomic features and evolutionary impact of the genes configuring duplicated pseudogenes in human.
abstract: Pseudogenes, regarded as 'genomic fossils', are DNA sequences resembling functional genes in perspective of sequence homology but completely non-functional. In this study, we explored the unique characteristic features of human genes, configuring classical duplicated pseudogenes. We found that progenitors of duplicated pseudogenes are characterized by a high expressivity, and ability to encode hub-proteins in association with a high evolutionary rate. Such unusual features are endorsed by longer protein length, elevated CpG content, and a high recombination rate. The non-functionalization of their duplicated copies can be attributed to the overabundance of gene paralog number in concert with functional redundancy.
authors: Bioinformatics Centre, Bose Institute, Kolkata, India.
authors: Kamalika
authors: K
authors: Sen
authors: Soumita
authors: S
authors: Podder
authors: Tapash Chandra
authors: TC
authors: Ghosh
mesh_terms: D018899:CpG Islands; D019143:Evolution, Molecular; D020440:Gene Duplication; D015894:Genome, Human; D006801:Humans; D011544:Pseudogenes; D011995:Recombination, Genetic