title: Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.
abstract: Alpha-synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of alpha-synuclein.
authors: California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA.
authors: Chengshan
authors: C
authors: Wang
authors: Nilam
authors: N
authors: Shah
authors: Garima
authors: G
authors: Thakur
authors: Feimeng
authors: F
authors: Zhou
authors: Roger M
authors: RM
authors: Leblanc
mesh_terms: D000388:Air; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry*; D051844:alpha-Synuclein / Q000737:chemistry*
chemical_list: D051844:alpha-Synuclein; D014867:Water