[Investistigation of the role of heterogenety individual radiosensitivity in estimation of radiation indused ageing].
The influence of heterogeneity in individual radiosensitivity on estimation of ageing using survival curve is considered. Quadratic deviation of the rate of ageing from the true value in estimated by imitation modeling techniques. The Gompertz model for spontaneous mortality and gamma-frailty model for heterogeneity are used. Simulation performed at different values of radiation effect and heterogeneity variance. It is shown that inclusion heterogeneity in the model is not efficient for large values of heterogeneity variance. For moderate values of heterogeneity variance model with heterogeneity produces more accurate results in comparison with the model without heterogeneity.
Mikhal'skiî
A I
AI
Ivanov
V K
VK
Chekin
S Iu
SIu
Maksiutov
M A
MA
Kashcheev
V V
VV
D000328:Adult; D000367:Age Factors; D000375:Aging / Q000235:genetics* / Q000528:radiation effects*; D014644:Genetic Variation; D006801:Humans; D008954:Models, Biological; D011836:Radiation Tolerance / Q000235:genetics*; D012044:Regression Analysis; D013269:Stochastic Processes