Cell type specificity of lung cancer associated with nitric oxide.
We aimed to explore whether lung cancer associated with air pollutants, specifically nitric oxide (NO), has cell type specificity. Both Spearman correlation and multiple linear regression between the air quality indices (SO(2), CO, O(3), NO, and NO(2)) and age-standardized incidence rate (ASR) of lung cancer by two major pathological types were calculated for both genders. We conducted 4 levels of analyses based on different NO concentrations. We also used Poisson regression to estimate the relative risk of lung cancer. Regardless of gender, the influences of SO(2), CO, O(3), and NO(2) were not statistically significant. There was a dose-response relationship between NO concentrations and adenocarcinoma (AC) incidence rates. On the other hand, none of the air pollutants had a significant impact on the squamous cell carcinoma (SCC) incidence rates for both males and females. The Poisson regression results showed that with the NO concentration < or = 5.59 ppb as the baseline, the risk for AC among males at 5.59 < NO < or = 8.55 ppb was 1.32 times of that at the baseline level (95% CI, 1.11-1.59), 1.33 times at 8.55 < NO < or = 13.54 ppb (95% CI, 1.11-1.61), 1.66 times when NO > 13.54 ppb (95% CI, 1.36-2.01). The test for trend was statistically significant at P<0.001. Similar results were observed among females. On the contrary, for SCC, we found NO did not pose any significant danger to males and females.


CONCLUSIONS
Our results showed that there was a dose-response relationship between gaseous NO concentrations and lung AC incidence rates.
Liaw
Yung-Po
YP
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan. Liawyp@csmu.edu.tw
Ting
Tih-Fen
TF
Ho
Chien-Chang
CC
Chiou
Ze-Ying
ZY
D000230:Adenocarcinoma / Q000453:epidemiology / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000378:metabolism / Q000633:toxicity*; D000397:Air Pollution / Q000706:statistics & numerical data; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism / Q000633:toxicity*; D055815:Young Adult
D000393:Air Pollutants; D009569:Nitric Oxide