title: Annular vesiculobullous eruptions in type 2 reaction in borderline lepromatous leprosy: a case report.
abstract: An untreated case of BL presented with clinical features of type 2 reaction (T2R) confirmed by histopathology. The case was a 18-year-old female with borderline lepromatous leprosy who developed annular vesiculobullous eruptions oversome of the pre-existing plaques on arms and upper back along with fever and severe neuritis after a short course of ofloxacin intake prescribed for urinary tract infection. In addition to the above lesions, some of the existing lesions showed acute exacerbation characterized by erythema, oedema, tenderness and vesiculobullous eruption. This can be considered as an example of leprous exacerbation as described in older literature. T2Rs are common in lepromatous leprosy and not so uncommonly are observed in borderline lepromatous leprosy. The vesiculobullous and crusted lesions developing over the existing borderline plaques, some of them presenting in an annular pattern in T2R in the form of leprous exacerbation, have been reported rarely in the literature.
authors: Department of Dermatology, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi-110001, India.
authors: H K
authors: HK
authors: Kar
authors: A
authors: A
authors: Raina
authors: P K
authors: PK
authors: Sharma
authors: M
authors: M
authors: Bhardwaj
mesh_terms: D000293:Adolescent; D002991:Clofazimine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004893:Erythema Nodosum / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage; D015439:Leprosy, Borderline / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D015440:Leprosy, Lepromatous / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D012008:Recurrence; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007917:Leprostatic Agents; D011239:Prednisolone; D002991:Clofazimine