[Methylphenidate: pharmacology, indication and potential of abuse].
Methylphenidate enhances dopaminergic neurotransmission in the central nervous system by same manner with cocaine and amphetamine that bind to the dopamine transporter and inhibit dopamine uptake. Methylphenidate improves social functions as well as clinical symptoms of patients suffered of narcolepsy and attention deficit hyperactivity disorder (ADHD), though it has the potential of abuse. It is reported that approximately 4% of older teens and emerging adults in the US annually misusing methylphenidate. Non-medical/illegal use of methylphenidate causes many consequences including addiction, negative reactions and medical complications. Growing number of illegal trades of methylphenidate and medical complications caused by misuse of methylphenidate urged Japanese government to introduce regulations limiting access to prescribed methylphenidate in 2008.
Tagaya
Hirokuni
H
Department of Health Science, School of Allied Health Sciences, Kitasato University.
D000328:Adult; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology / Q000627:therapeutic use; D009290:Narcolepsy / Q000188:drug therapy; D019966:Substance-Related Disorders
D008774:Methylphenidate