Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model.
Diabetic nephropathy is a common, complex disease with a clear genetic predisposition. Human gene association studies are beginning to bear fruit by identifying gene loci that increase diabetic nephropathy risk. Chua et al. report a similar study in diabetic mice that reveals a major nephropathy locus on chromosome 8. Could this be a human nephropathy gene? Time will tell, but such findings will at least improve the use of mouse models of human kidney disease.
Brosius
Frank C
FC
Department of Internal Medicine, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680, USA. fbrosius@umich.edu
D000818:Animals; D002874:Chromosome Mapping; D003928:Diabetic Nephropathies / Q000235:genetics*; D004195:Disease Models, Animal; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D051379:Mice; D008810:Mice, Inbred C57BL