Pneumocystis jirovecii dihydropteroate synthase (DHPS) genotypes in non-HIV-immunocompromised patients: a tertiary care reference health centre study.
Studies on Pneumocystis jirovecii dihydropteroate synthase (DHPS) genotypes among non-HIV immunocompromised patients from developing countries are rare. In the present prospective investigation, 24 (11.8%) cases were found to be positive for Pneumocystis jirovecii out of 203 non-HIV patients with a clinical suspicion of Pneumocystis pneumonia (PCP). Dihydropteroate synthase (DHPS) genotype 1 (Thr55+Pro57) was noted in 95.8% P. jirovecii isolates in the present study in contrast to only 4.1% of patients with DHPS genotype 4 (Thr55Ala + Pro57Ser).
Tyagi
A K
AK
Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Mirdha
B R
BR
Luthra
K
K
Guleria
R
R
Mohan
A
A
Singh
U B
UB
Samantaray
J C
JC
Dar
L
L
Iyer
V K
VK
Sreenivas
V
V
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004094:Dihydropteroate Synthase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000382:microbiology*; D011446:Prospective Studies; D055815:Young Adult
D004094:Dihydropteroate Synthase