title: Gene-specific epigenetic regulation in serious infections with systemic inflammation.
abstract: Inflammation is a fundamental biologic process that is evolutionally conserved by a germ line code. The interplay between epigenetics and environment directs the code into temporally distinct inflammatory responses, which can be acute or chronic. Here, we discuss the epigenetic processes of innate immune cells during serious infections with systemic inflammation in four stages: homeostasis, incitement, evolution, and resolution. We describe feed-forward loops of serious infections with systemic inflammation that create gene-specific silent facultative heterochromatin and active euchromatin according to gene function, and speculate on the role of epigenetics in survival.
authors: Translational Science Institute, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. chmccall@wfubmc.edu
authors: Charles E
authors: CE
authors: McCall
authors: Barbara
authors: B
authors: Yoza
authors: Tiefu
authors: T
authors: Liu
authors: Mohamed
authors: M
authors: El Gazzar
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D057890:Epigenomics; D005786:Gene Expression Regulation; D006801:Humans; D007239:Infections / Q000235:genetics* / Q000276:immunology; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D051379:Mice