[Molecular pathology of sarcomas. Update on the research group "Molecular Diagnosis of Sarcomas"].
To establish precise diagnostic algorithms and standardised treatment of sarcomas in specialized centers, the interdisciplinary research group KoSar (sarcoma competence network) has been funded by German Cancer Aid. A sarcoma tissue repository and a diagnostic reference center have been set up, presently containing about 1000 accurately diagnosed sarcomas of different entities. Significant gene expression profiles for synovial sarcomas, leiomyosarcomas, myxoid liposarcomas and a small profile for myxofibrosarcomas as well as a new classification of angiosarcomas were defined. We systematically searched for activated signal transduction pathways in sarcoma cell lines and xenograft transplant models and candidate targets for molecular therapies were identified. Based on these results first clinical studies have been initiated by the German Interdisciplinary Sarcoma Study Group (GISG).
Rüsseler
A V
AV
Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127 Bonn. vanessa.ruesseler@ukb.uni-bonn.de
Brors
B
B
Fischer
T
T
Hartmann
J T
JT
Hartmann
W
W
Hohenberger
P
P
Lichter
P
P
Marx
A
A
Mechtersheimer
G
G
Penzel
R
R
Renner
M
M
Schildhaus
H-U
HU
Schirmacher
P
P
Sievers
E
E
Ströbel
P
P
Wardelmann
E
E
Ziesché
E
E
Büttner
R
R
D000818:Animals; D035843:Biomedical Research; D045744:Cell Line, Tumor; D003299:Cooperative Behavior; D004353:Drug Evaluation, Preclinical; D005354:Fibrosarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D033183:Interdisciplinary Communication; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D018208:Liposarcoma, Myxoid / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D025202:Molecular Diagnostic Techniques; D058990:Molecular Targeted Therapy; D009368:Neoplasm Transplantation; D012509:Sarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D013584:Sarcoma, Synovial / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics