title: Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
abstract: BACKGROUND
  Prostate cancer is the most commonly diagnosed non-skin cancer in men in the United States and the second leading cause of cancer-related mortality. African American men have substantially increased risk of both being diagnosed and dying from the disease. Recent genome-wide genetic association studies have identified a number of common single nucleotide genetic polymorphisms (SNPs) that are associated with prostate cancer in men of European descent. Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans.
  
  
  METHODS
  We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent.
  
  
  RESULTS
  We found nominal evidence (P < 0.05) for association between prostate cancer and three chromosome 8q24 (rs6983561, rs16901979, and rs7000448) and two 10q11 (rs7904463 and rs10740051) SNPs.
  
  
  CONCLUSIONS
  We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans. Our report is the first to find evidence of association between SNPs near MSMB and prostate cancer in African Americans. Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.
authors: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
authors: Yunfei
authors: Y
authors: Wang
authors: Anna M
authors: AM
authors: Ray
authors: Emilie K
authors: EK
authors: Johnson
authors: Kimberly A
authors: KA
authors: Zuhlke
authors: Kathleen A
authors: KA
authors: Cooney
authors: Ethan M
authors: EM
authors: Lange
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D002879:Chromosomes, Human, Pair 10; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*