title: [Remifentanil provides fast recovery and hemodynamic stability in laryngomicrosurgery anesthesia].
abstract: BACKGROUND
  Stressful procedures such as intratracheal intubation and direct laryngoscopy in very short operations make anesthetic management for laryngomicrosurgery difficult. This study was conducted to evaluate which anesthetic agent, remifentanil or fentanyl, is suitable in anesthesia for laryngomicrosurgery.
  
  
  METHODS
  After obtaining informed consent prior to the study, 18 patients undergoing elective laryngomicrosurgery were randomly allocated to one of two groups to receive remifentanil (R group) or fentanyl (F group). Patients with ages above 76 years and moderate abnormalities in cardiovascular system or respiratory system were excluded.
  
  
  RESULTS
  Average infusion rate of remifentanil was 0.24 +/- 0.02 microg x kg(-1) x min(-1) and total infused dose of fentanyl was 0.27 +/- 0.05 mg. Average bispectral index values in both groups were comparable. Cases needing sevoflurane inhalation to control blood pressure were significantly more in F group than in R group. Heart rate was significantly lower in R group than in F group. Duration from the end of operation to responses to verbal commands and extubation was significantly shorter in R group than in F group.
  
  
  CONCLUSIONS
  Remifentanil provided faster recovery and hemodynamic stability. Therefore, remifentanil seems to be more suitable than fentanyl in anesthesia for laryngomicrosurgery.
authors: Department of Anesthesiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511.
authors: Yoshihiko
authors: Y
authors: Kishi
authors: Hironobu
authors: H
authors: Tanigami
authors: Kiyokazu
authors: K
authors: Kagawa
authors: Yoshimi
authors: Y
authors: Asakura
authors: Shunji
authors: S
authors: Sonoda
authors: Yuki
authors: Y
authors: Hiuge
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007830:Larynx / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D005283:Fentanyl