title: Using electron beam radiation to simulate the dose distribution for whole body solar particle event proton exposure.
abstract: As a part of the near solar system exploration program, astronauts may receive significant total body proton radiation exposures during a solar particle event (SPE). In the Center for Acute Radiation Research (CARR), symptoms of the acute radiation sickness syndrome induced by conventional radiation are being compared to those induced by SPE-like proton radiation, to determine the relative biological effectiveness (RBE) of SPE protons. In an SPE, the astronaut's whole body will be exposed to radiation consisting mainly of protons with energies below 50 MeV. In addition to providing for a potentially higher RBE than conventional radiation, the energy distribution for an SPE will produce a relatively inhomogeneous total body dose distribution, with a significantly higher dose delivered to the skin and subcutaneous tissues than to the internal organs. These factors make it difficult to use a (60)Co standard for RBE comparisons in our experiments. Here, the novel concept of using megavoltage electron beam radiation to more accurately reproduce both the total dose and the dose distribution of SPE protons and make meaningful RBE comparisons between protons and conventional radiation is described. In these studies, Monte Carlo simulation was used to determine the dose distribution of electron beam radiation in small mammals such as mice and ferrets as well as large mammals such as pigs. These studies will help to better define the topography of the time-dose-fractionation versus biological response landscape for astronaut exposure to an SPE.
authors: Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. keith.cengel@uphs.upenn.edu
authors: Keith A
authors: KA
authors: Cengel
authors: Eric S
authors: ES
authors: Diffenderfer
authors: Stephen
authors: S
authors: Avery
authors: Ann R
authors: AR
authors: Kennedy
authors: James
authors: J
authors: McDonough
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes / Q000032:analysis; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006801:Humans; D051379:Mice; D019047:Phantoms, Imaging; D011522:Protons; D011834:Radiation Monitoring; D012984:Software; D019445:Solar Activity; D013552:Swine; D014867:Water / Q000737:chemistry; D014916:Whole-Body Irradiation
chemical_list: D003037:Cobalt Radioisotopes; D011522:Protons; D014867:Water