title: Short synthesis of the seed germination inhibitor 3,4,5-trimethyl-2(5H)-furanone.
abstract: 3,4,5-Trimethyl-2(5H)-furanone, a new seed germination inhibitor with very promising agrochemical applications, was efficiently synthesized from 2,3-dimethylmaleic anhydride via nucleophilic addition of methyllithium followed by reduction using sodium borohydride. This two-step synthesis is straightforward and high-yielding and permits the large-scale preparation of the seed germination inhibitor.
authors: Research Foundation -Flanders, FWO - Vlaanderen, Belgium.
authors: Riccardo
authors: R
authors: Surmont
authors: Guido
authors: G
authors: Verniest
authors: Norbert
authors: N
authors: De Kimpe
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D012639:Seeds / Q000187:drug effects / Q000254:growth & development; D013237:Stereoisomerism
chemical_list: C548099:3,4,5-trimethylfuran-2(5H)-one; D005663:Furans