[Carcinogenic aging].
There are data that show that under the influence of chemical carcinogens of various classes (polycyclic aromatic hydrocarbons, nitroso compounds, aromatic amines), mutagens, ionizing radiation, extremely low frequency radio waves, constant illumination, tobacco smoking, the development premature hotmonal-metabolic disturbances in the main homeostatic systems (nervous, endocrine, immune and energy) similar to these developed during the normal aging have a place. These disturbances facilitate the realization of promotion and progression stages ofcarcinogenesis. Geneticall modified animals (mutants, transgenic or knockout) open new opportunity for the analyses of the role of separate genes in the relationships between natural and accelerated by the exposure to environmental factors aging. The increase in tumor incidence usually observed in genetically modified mice with phenotypical features of premature or accelerated aging whereas in animals revealed the delayed aging the increase of tumor latensy and/or decrease of tumor incidence have observed. The treatment with geroprotectors of member of populations at risk of accelerated aging induced by environmental factors may serves as effective means of primary cancer prevention.
Anisimov
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D000375:Aging; D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D012307:Risk Factors