Measurement of inflammation and oxidative stress following drastic changes in air pollution during the Beijing Olympics: a panel study approach.
Ambient air pollution has been linked to cardiovascular and respiratory morbidity and mortality in epidemiology studies. Frequently, oxidative and nitrosative stress are hypothesized to mediate these pollution effects, however precise mechanisms remain unclear. This paper describes the methodology for a major panel study to examine air pollution effects on these and other mechanistic pathways. The study took place during the drastic air pollution changes accompanying the 2008 Olympics in Beijing, China. After a general description of air pollution health effects, we provide a discussion of panel studies and describe the unique features of this study that make it likely to provide compelling results. This study should lead to a clearer and more precise definition of the role of oxidative and nitrosative stress, as well as other mechanisms, in determining acute morbidity and mortality from air pollution exposure.
Kipen
Howard
H
University of Medicine and Dentistry of New Jersey - School of Public Health and Robert Wood Johnson Medical School, Piscataway, New Jersey, USA. kipen@eohsi.rutgers.edu
Rich
David
D
Huang
Wei
W
Zhu
Tong
T
Wang
Guangfa
G
Hu
Min
M
Lu
Shou-en
SE
Ohman-Strickland
Pamela
P
Zhu
Ping
P
Wang
Yuedan
Y
Zhang
Jim Junfeng
JJ
D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002681:China / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D013177:Sports
D000393:Air Pollutants; D015415:Biomarkers