Gabapentin withdrawal syndrome in a post-liver transplant patient.
A 41-year-old male with a previous orthotopic liver transplant began experiencing insomnia, anxiety, diaphoresis, headaches, and palpitations that progressed over a 2-day period. As part of his home medication regimen, the patient was taking gabapentin for peripheral neuropathy. His acute onset of increasing symptoms coincided with an inadvertent discontinuation of gabapentin. After reinitiation of gabapentin therapy, the symptoms slowly improved over the next 24 hours and the episode of gabapentin withdrawal syndrome resolved.
Finch
Christopher K
CK
Clinical Pharmacy Services, Methodist University Hospital, University of Tennessee, College of Pharmacy, Memphis, Tennessee 38104, USA.
Eason
James
J
Usery
Justin B
JB
D000328:Adult; D000588:Amines / Q000008:administration & dosage / Q000009:adverse effects*; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D000077206:Gabapentin; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects*
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin