[A case of interstitial pneumonitis induced by S-1].
S-1, an oral fluoropyrimidine derivative, has been identified as an effective agent for the treatment of breast cancer. We present here a case of interstitial pneumonitis that occurred after S-1 treatment. A n 80-year-old woman was diagnosed with stage III infiltrating ductal carcinoma of the left breast and underwent a modified radical mastectomy in November 2001, followed by six courses of paclitaxel. In October 2008, metastatic disease was detected in her skeletal system. Therefore, S-1 chemotherapy was initiated (100 mg/body). Five days after starting S-1, she developed severe eruptions along with dyspnea. X-rays and CT scan showed diffuse ground glass shadow. Both her symptoms and the radiographic findings resolved dramatically after the start of high-dose corticosteroid therapy. Clinicians should be aware that S-1 has the potential to cause lung injury when it is included in chemotherapy.
Ueyama
Yosuke
Y
Dept. of Surgery, Kansai Medical University.
Yamamoto
Daigo
D
Yoshida
Hideyuki
H
Kanematsu
Sayaka
S
Nakatake
Richi
R
Kasahara
Noriko
N
Tanaka
Kanji
K
Shoji
Tetsuji
T
Okukawa
Homa
H
Kwon
A-Hon
AH
D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D009362:Neoplasm Metastasis / Q000188:drug therapy; D010094:Oxonic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D005641:Tegafur / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid