[Elucidation of compatibility principle and scientific value of Chinese medical formulae based on pharmacometabolomics].
By using UPLC coupled with MS, the analysis of the constituents absorbed into blood after oral administration of Yinchenhao decotion with different combination had been carried out, the body fate of constituents detected in the blood was elucidated also; At the same time, the overall body respones after multi-input of the medical formule were evaluated by metabolomic analysis. These data explained the scientific values in both drug metabolisim and metabonomics, the results had given some new evidences for the potentialities of pharmacometabonomics to elucidate the compatibility principle of Chinese medical formule. As a conclusion, concept of "Pharmacometabolomics of Chinmediformulae" has been defined.
Wang
Xijun
X
Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Zhang
Boli
B
D002626:Chemistry, Pharmaceutical; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D006801:Humans; D008516:Medicine, Chinese Traditional; D055432:Metabolomics
D004365:Drugs, Chinese Herbal