title: Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
abstract: Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.
authors: Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.
authors: Akiyuki
authors: A
authors: Ikedo
authors: Ichiro
authors: I
authors: Hayakawa
authors: Takeo
authors: T
authors: Usui
authors: Sayaka
authors: S
authors: Kazami
authors: Hiroyuki
authors: H
authors: Osada
authors: Hideo
authors: H
authors: Kigoshi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D007887:Fabaceae / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007529:Isoflavones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones; C521560:glaziovianin A