title: Granulomatous interstitial nephritis in chronic lymphocytic leukaemia.
abstract: We present a case of granulomatous interstitial nephritis (GIN) associated with chronic lymphocytic leukaemia (CLL). GIN is a rare pathological finding noted in renal biopsy specimens. Furthermore, CLL does not usually cause GIN. In this case, acute renal injury probably resulted from GIN, and urgent dialysis was required, despite sufficient chemotherapy. Immunohistochemical analyses of a biopsy specimen revealed invasion of CD20( +) CLL cells, surrounded by reactive T cells, and granuloma formation. Thus, CLL may induce secondary interstitial nephritis as a granulomatous reaction.
authors: Department of Nephrology, Saitama Medical University, Saitama, Japan. t_inoue@saitama-med.ac.jp
authors: Tsutomu
authors: T
authors: Inoue
authors: Takahiko
authors: T
authors: Sato
authors: Hirokazu
authors: H
authors: Okada
authors: Hidekazu
authors: H
authors: Kayano
authors: Yusuke
authors: Y
authors: Watanabe
authors: Tomohiro
authors: T
authors: Kikuta
authors: Masahiro
authors: M
authors: Tsuda
authors: Keita
authors: K
authors: Sueyoshi
authors: Tsuneo
authors: T
authors: Takenaka
authors: Hiromichi
authors: H
authors: Suzuki
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D017252:CD3 Complex / Q000378:metabolism; D018956:CD5 Antigens / Q000378:metabolism; D002465:Cell Movement; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis* / Q000209:etiology*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D017252:CD3 Complex; D018956:CD5 Antigens