Apolipoprotein B in type 2 diabetics--a cross sectional study in a tertiary care set-up.
OBJECTIVE
To analyze the pattern of dyslipidaemias including apolipoprotein B in type 2 diabetes.


METHODS
A total of 120 diabetics were studied for their lipid profile including serum triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol in fasting state, along with apolipoprotein B levels.


RESULTS
Raised apolipoprotein B was the most frequent lipid disorder in type 2 diabetics, occurring in 56.7% of the studied patients. This was followed by high serum triglycerides levels in 55.8% and low HDL cholesterol levels in 55% of patients. Notably, 6% patients had normal triglyceride levels accompanied by raised LDL cholesterol, compared to 20% patients who had normal triglycerides with high apolipoprotein B levels. Overall, 36% of patients had normal LDL cholesterol values but elevated apolipoprotein B.


CONCLUSIONS
Apolipoprotein B is the most frequently occurring dyslipidaemia in type 2 diabetes. It identifies individuals with high risk of coronary heart disease not otherwise detected on routine lipid profile.
Kanani
Fatima Husain
FH
Department of Chemical Pathology, Liaquat National Hospital, Karachi.
Alam
Junaid Mehmood
JM
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides