Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C-H bond functionalization nexus.
Regioselective syntheses of 1,4,5-trisubstituted 1,2,3-triazoles were accomplished by three different strategies, relying on (i) the interception of stoichiometrically formed 5-cuprated-1,2,3-triazoles, (ii) the use of stoichiometrically functionalized alkynes or (iii) catalytic C-H bond functionalizations. This perspective article summarizes progress in this research area until June 2010.
Ackermann
Lutz
L
Institut fuer Organische und Biomolekulare Chemie, Georg-August Universiteat, Tammannstrasse. 2, 37077 Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de
Potukuchi
Harish Kumar
HK
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007700:Kinetics; D009942:Organometallic Compounds / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D009942:Organometallic Compounds; D014230:Triazoles; D003300:Copper