Mechanisms of growth cone repulsion.
Research conducted in the last century suggested that chemoattractants guide cells or their processes to appropriate locations during development. Today, we know that many of the molecules involved in cellular guidance can act as chemorepellents that prevent migration into inappropriate territories. Here, we review some of the early seminal experiments and our current understanding of the underlying molecular mechanisms.
Krull
Catherine E
CE
Biologic and Materials Sciences, University of Michigan, 5211 Dental, 1011 North University Avenue, Ann Arbor, MI 48109, USA.
Eisen
Judith S
JS