title: Long-term follow-up and management of prenatally detected, isolated hydronephrosis.
abstract: OBJECTIVE
  The aim of the study was to determine the outcome and management of infants with isolated hydronephrosis, detected prenatally and confirmed postnatally.
  
  
  METHODS
  Between January 1988 and January 2008, the files of 629 children (492 males and 137 females), who were diagnosed prenatally with isolated, unilateral hydronephrosis, and the diagnosis was confirmed postnatally, were retrospectively reviewed. The median follow-up time was 142 months. Serial ultrasonography and isotope diuretic renography nuclear imaging were performed. Hydronephrosis was assessed and classified according to the Society of Fetal Urology (SFU) grading system.
  
  
  RESULTS
  Initially, all of the children were treated conservatively. Stabilization occurred in all children with grade 1 hydronephrosis, in 87% of children (144) with grade 2 hydronephrosis, and in 30% of children (37) with grade 3 hydronephrosis. However, 13% of children (21) with grade 2 hydronephrosis, 70% of children (85) with grade 3 hydronephrosis, and 100% of children with grade 4 hydronephrosis received surgical intervention according to our predetermined criteria. Ninety-five patients (late pyeloplasty group) were treated for a reduction for a differential renal function (DRF) to less than 40%, and 80 children (early pyeloplasty group) underwent surgery for a DRF more than 40%, but hydronephrosis progressed to higher grades or failed to improve and had poor radiotracer clearance. Significant improvements after pyeloplasty were noted in both groups with respect to the DRF and the ratio of the depth of the calyces to the thickness of the parenchyma (C/P ratio; P < .0001). The improvement in DRF was greater in the late pyeloplasty group than the early pyeloplasty group (P = .044), whereas the improvement in the C/P ratio was greater in the early pyeloplasty group than the late pyeloplasty group (P = .001). The ipsilateral DRF was preserved in the early pyeloplasty group, whereas the ipsilateral DRF was still less than 40% in the late pyeloplasty group. The improvement in DRF was significant during the first year postoperatively and became stable thereafter. The C/P ratio was inversely correlated with the DRF in the patients before and after pyeloplasty (r = -0.257; P = .01; and r = -0.616; P = .001, respectively).
  
  
  CONCLUSIONS
  All infants with SFU-1 and most infants with SFU-2 hydronephrosis have relatively benign conditions and do not need an invasive procedure. Although greater improvement occurred in patients with an initial DRF less than 40%, the reduced DRF did not recover to the predeterioration level postoperatively. Earlier surgical intervention after a short period of strict clinical surveillance is beneficial for preserving renal function for patients with persistent SFU-3 or SFU-4 hydronephrosis.
authors: Department of Pediatric Surgery, the Shengjing Hospital of China Medical University, Shenyang 110004, China. yangxy70@hotmail.com
authors: Yi
authors: Y
authors: Yang
authors: Ying
authors: Y
authors: Hou
authors: Zhi Bin
authors: ZB
authors: Niu
authors: Chang Lin
authors: CL
authors: Wang
mesh_terms: D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D006869:Hydronephrosis / Q000145:classification / Q000175:diagnosis* / Q000601:surgery*; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000601:surgery; D007677:Kidney Function Tests; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D011866:Radioisotope Renography / Q000379:methods; D016284:Technetium Tc 99m Pentetate; D016896:Treatment Outcome; D013520:Urologic Surgical Procedures / Q000379:methods
chemical_list: D016284:Technetium Tc 99m Pentetate