Multigenerational inheritance and clinical characteristics of three large pedigrees with early-onset type 2 diabetes in Jamaica.
OBJECTIVE
To document the existence and clinical characteristics of three large families with multigenerational inheritance of early-onset type 2 diabetes in Jamaica.


METHODS
Three probands from large families with multigenerational inheritance of early-onset type 2 diabetes in at least three generations were detected at the University Hospital of the West Indies in Jamaica. Each proband at the time of diagnosis was < 25 years of age, was lean, and did not require insulin therapy. Clinical, metabolic, and genetic assessments were undertaken to profile the diabetes in the three families.


RESULTS
Three pedigrees--BK, SU, and CA--consisting of 38, 48, and 113 members, respectively, with multigenerational inheritance of early-onset type 2 diabetes in at least three generations, were investigated. The mean age at diagnosis of the three pedigrees was 31.5 +/- 2.9 years, with 10 persons detected below 25 years of age. Findings suggestive of overweight, insulin resistance, low insulin secretion, dyslipidemia, and mild intra-abdominal obesity were present. Islet cell antibodies and sequence variants in MODY1 to -6 genes were absent.


CONCLUSIONS
Large families demonstrating multigenerational inheritance of diabetes and other characteristics consistent with early-onset type 2 diabetes are present in the Jamaican population.
Mills
James L
JL
Department of Basic Medical Sciences, University of the West Indies, Kingston, Jamaica. james.mills@uwimona.edu.jm
Irving
Rachael R
RR
Choo-Kang
Eric G
EG
Wright-Pascoe
Rosemarie
R
McLaughlin
Wayne
W
Mullings
Anthony A
AA
Morrison
Errol Y
EY
Gabay
Leslie
L
D050153:Abdominal Fat; D000328:Adult; D017668:Age of Onset; D000886:Anthropometry; D001323:Autoantibodies / Q000097:blood; D001835:Body Weight; D002648:Child; D015897:Comorbidity; D004252:DNA Mutational Analysis; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000276:immunology; D007563:Jamaica / Q000453:epidemiology; D008297:Male; D010375:Pedigree
D001323:Autoantibodies; D006442:Glycated Hemoglobin; D007328:Insulin