[Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds].
Neonatal hypophysectomy in chicken produces enlarged follicles of the thyroid gland, accumulation of colloids, impressed follicular epithelium, increased nucleus-cytoplasm ratio in thyrocytes, atrophied inter-follicular epithelium, depressed immunity, development of hypercoagulation and depressed fibrinolysis. When hypophysectomy is performed in one-year-old birds the impairments developing in thyroid morphology, immunity and hemostasis are less pronounced. Peptides of the anterior (Lys-Glu-Asp-Gly) and posterior (Ala-Glu-Asp-Gly) thyroid lobes injected to hypophysectomized birds prevent atrophic changes of the thyroid gland, normalize immune and hemostatic parameters.
Kuznik
B I
BI
Pateiuk
A V
AV
Rusaeva
N S
NS
Baranchugova
L M
LM
Obydenko
V I
VI
D000818:Animals; D002645:Chickens; D005342:Fibrinolysis / Q000187:drug effects* / Q000276:immunology*; D006487:Hemostasis / Q000187:drug effects* / Q000276:immunology*; D007016:Hypophysectomy; D009842:Oligopeptides / Q000494:pharmacology*; D019851:Thrombophilia / Q000276:immunology* / Q000473:pathology; D013961:Thyroid Gland / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine