Altered calcium homeostasis is correlated with the presence of metabolic syndrome and diabetes in middle-aged and elderly Korean subjects: the Chungju Metabolic Disease Cohort study (CMC study).
OBJECTIVE
To clarify the association of serum calcium level with metabolic syndrome (MetS) and diabetes in middle-aged and elderly Korean subjects.


METHODS
We conducted a population-based, cross-sectional survey of 1329 participants aged over 40 years (median age 65.8) in a rural area of Chungju, Korea, in 2007.


METHODS
Serum level of albumin, calcium, 25-hydroxy-vitamin D and intact parathyroid hormone were measured in a central laboratory.


RESULTS
The prevalence of MetS increased progressively with elevated serum albumin-corrected calcium levels (P<0.001 for trend). After adjusting for various covariates, subjects in the highest quintile group (2.45-2.99 mmol/L) compared with the lowest quintile group (2.05-2.24 mmol/L) of serum calcium levels had an odds ratio (OR) for having MetS of 3.11 (95% confidence intervals, CI, 1.95-4.97; P for trend<0.001). Excluding the subjects with hypocalcemia and hypercalcemia (n=1064) did not alter this significant association. After multiple adjustment, subjects with serum calcium levels in the fourth to fifth quintiles had a 2.0- to 3.0-fold increased OR of having diabetes (first quintile reference, fourth quintiles OR 2.38; 95% CI 1.32-4.28, fifth quintiles OR 3.32; 95% CI 1.87-5.88; P for trend<0.001).The associations of serum calcium levels with the incidences of MetS or diabetes were unchanged after adjustment for 25(OH)D and PTH levels.


CONCLUSIONS
Altered calcium homeostasis was associated with an increased risk of having MetS and diabetes in this demographic group.
Kim
Mee Kyoung
MK
Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim
Guilsun
G
Jang
Eun Hee
EH
Kwon
Hyuk Sang
HS
Baek
Ki Hyun
KH
Oh
Ki Won
KW
Lee
Jin Hee
JH
Yoon
Kun-Ho
KH
Lee
Won Chul
WC
Lee
Kang Woo
KW
Son
Ho Young
HY
Kang
Moo Il
MI
D000368:Aged; D000418:Albumins; D002118:Calcium / Q000378:metabolism*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk
D000418:Albumins; D002118:Calcium