title: Comparison of A-line autoregressive index and observer assessment of alertness/sedation scale for monitored anesthesia care with target-controlled infusion of propofol in patients undergoing percutaneous vertebroplasty.
abstract: BACKGROUND
  Percutaneous vertebroplasty (PV) with monitored anesthesia care (MAC) is a growing trend. Without adequate sedation, patient movement can affect and even interrupt the procedure during MAC. The aim of this study was to compare the performance of the auditory-evoked potential (AEP) index and the Observer Assessment of Alertness/Sedation (OAA/S) scale as indicators of depth of sedation in patients undergoing PV.
  
  
  METHODS
  Two hundred and twenty patients in ASA II to III, aged 43 to 92 years, undergoing elective PV with MAC, were randomly allocated to the AEP or the OAA/S group (n = 110 each). Initially, all patients received 1 μg/kg of fentanyl and 0.02 mg/kg of midazolam intravenously and sedation with a target-controlled infusion (TCI) of propofol at a target concentration of 1.2 μg/mL. The concentration for the propofol TCI was adjusted in 0.2 μg/mL increments or decrements according to the A-Line autoregressive index (AAI) or the OAA/S scale. A blinded study nurse recorded the measured parameters.
  
  
  RESULTS
  Some parameters were significantly different in the AEP group compared with the OAA/S group: lower AAI, lower OAA/S score, lower respiratory rates, and higher end-tidal carbon dioxide pressure were noted from local anesthetic infiltration to bone cement implantation, fewer patients whose movements affected the procedure (10 vs. 36, respectively, P < 0.001), and more adjustments of TCI (twice vs. once, respectively, P < 0.006). The surgeons' satisfaction was greater for the AEP group than for the OAA/S group.
  
  
  CONCLUSIONS
  TCI propofol with AEP monitoring can provide less patient movement, better sedation, and higher surgeon satisfaction in patients during prone-position PV procedures than can TCI propofol with OAA/S monitoring.
authors: Departments of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors: Bo-Feng
authors: BF
authors: Lin
authors: Yuan-Shiou
authors: YS
authors: Huang
authors: Chang-Po
authors: CP
authors: Kuo
authors: Da-Tong
authors: DT
authors: Ju
authors: Chueng-He
authors: CH
authors: Lu
authors: Chen-Hwan
authors: CH
authors: Cherng
authors: Ching-Tang
authors: CT
authors: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous; D001288:Attention / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood; D016292:Procedural Sedation; D056805:Consciousness Monitors; D004562:Electrocardiography; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D005283:Fentanyl; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D010092:Oximetry; D017060:Patient Satisfaction; D016684:Prone Position; D015742:Propofol; D056152:Respiratory Rate / Q000187:drug effects; D016683:Supine Position; D054854:Vertebroplasty / Q000379:methods*
chemical_list: D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol