DNA photocleavage by an osmium(II) complex in the PDT window.
The extended pi-delocalization of dppn (benzo[i]dipyrido[3,2-a:2,3-c]phenazine) results in a (3)pipi* state as the lowest triplet excited state in [Os(bpy)(2)(dppn)](2+) (bpy = 2,2'-bipyridine), which generates a (1)O(2) quantum yield of 0.42. Together with its (3)MLCT absorption, this new osmium complex shows efficient DNA cleavage under irradiation of lambda(irr) > or = 645 nm.
Sun
Yujie
Y
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Joyce
Lauren E
LE
Dickson
Nicole M
NM
Turro
Claudia
C
D015082:2,2'-Dipyridyl / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D053837:DNA Cleavage; D008968:Molecular Conformation; D009992:Osmium / Q000737:chemistry*; D011789:Quantum Theory
D056831:Coordination Complexes; D009992:Osmium; D015082:2,2'-Dipyridyl; D004247:DNA