title: Mitochondria and aging in the vascular system.
abstract: This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants.
authors: Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK 73104, USA. zoltan-ungvari@ouhsc.edu
authors: Zoltan
authors: Z
authors: Ungvari
authors: William E
authors: WE
authors: Sonntag
authors: Anna
authors: A
authors: Csiszar
mesh_terms: D000375:Aging / Q000502:physiology*; D001808:Blood Vessels / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species