Microtubule-dependent spatial organization of mitochondria in fission yeast.
The microtubule cytoskeleton has an important role in the control of mitochondrial distribution in higher eukaryotes. In humans, defects in axonal mitochondrial transport are linked to neurodegenerative diseases. This chapter highlights fission yeast Schizosaccharomyces pombe as a powerful genetic model system for the study of microtubule-dependent mitochondrial movement, dynamics and inheritance.
Das
Maitreyi
M
Department of Molecular and Cellular Pharmacology (R-189), University of Miami Miller School of Medicine, Miami, Florida 33101, USA.
Chiron
Stéphane
S
Verde
Fulvia
F
D002458:Cell Fractionation / Q000379:methods; D055032:Electron Microscope Tomography / Q000379:methods; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D009068:Movement / Q000502:physiology; D012568:Schizosaccharomyces / Q000378:metabolism* / Q000648:ultrastructure*; D013194:Staining and Labeling / Q000379:methods; D014018:Tissue Distribution