title: Orbitofrontal contributions to human working memory.
abstract: Although cognitive neuroscience has made remarkable progress in understanding the involvement of the prefrontal cortex in human memory, the necessity of the orbitofrontal cortex for key competencies of working memory remains largely unexplored. We therefore studied human brain lesion patients to determine whether the orbitofrontal cortex is necessary for working memory function, administering subtests of the Wechsler memory scale, the Wechsler adult intelligence scale, and the n-back task to 3 participant groups: orbitofrontal lesions (n = 24), prefrontal lesions not involving orbitofrontal cortex (n = 40), and no brain lesions (n = 54). Orbitofrontal damage was reliably associated with deficits on neuropsychological tests involving the coordination of working memory maintenance, manipulation, and monitoring processes (n-back task) but not on pure tests of working memory maintenance (digit/spatial span forward) or manipulation (digit/spatial span backward and letter-number sequencing). Our findings elucidate a central component of the neural architecture of working memory, providing key neuropsychological evidence for the necessity of the orbitofrontal cortex in executive control functions underlying the joint maintenance, manipulation, and monitoring of information in working memory.
authors: Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, MD 20892, USA.
authors: Aron K
authors: AK
authors: Barbey
authors: Michael
authors: M
authors: Koenigs
authors: Jordan
authors: J
authors: Grafman
mesh_terms: D001930:Brain Injuries / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed