Influence of fenpropathrin on memory and movement in mice after transient incomplete cerebral ischemia.
Fenpropathrin, a synthetic pyrethroid widely used as an insecticide, is known to affect locomotion and memory in mammals. It is possible that exposure to pyrethroids may occur in an elderly population where transient ischemic attacks are a higher risk for occurrence with consequent changes in memory and control of movement. Thus, the aim of this study was to determine whether bilateral clamping of carotid arteries (BCCA), a model for ischemia, together with fenpropathrin affected memory in tests such as the passive avoidance task and fresh spatial memory in a Y-maze, as well as movement activity and movement coordination on a rotarod in mice. BCCA together with fenpropathrin significantly reduced latency in a passive avoidance task compared to controls. There were no significant differences among the groups with respect to the Y-maze, movement activity, or movement coordination. In conclusion, fenpropathrin needs to be used with caution in the presence of an elderly population at risk for ischemia, as there appears to be evidence of some memory loss in mice.
Nieradko-Iwanicka
Barbara
B
Department of Hygiene, Medical University of Lublin, Lublin, Poland. bnieradkoiwanicka@wp.pl
Borzecki
Andrzej
A
D000818:Animals; D002339:Carotid Arteries / Q000503:physiopathology; D005260:Female; D007306:Insecticides / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000209:etiology; D051379:Mice; D011722:Pyrethrins / Q000494:pharmacology*
D007306:Insecticides; D011722:Pyrethrins; C044267:fenpropathrin