title: Neurocysticercosis: unraveling the nature of the single cysticercal granuloma.
abstract: A single enhancing lesion in the brain parenchyma, also called an inflammatory granuloma, is a frequent neurologic diagnosis. One of the commonest causes of this lesion is human neurocysticercosis, the infection by the larvae of the pork tapeworm, Taenia solium. Following the demonstration that viable cysticercosis cysts survive in good conditions for several years in the human brain, single cysticercal granulomas have been consistently interpreted as representing late degeneration of a long-established parasite. On the basis of epidemiologic, clinical, and laboratory evidence detailed in this article, we hypothesize that in most cases these inflammatory lesions correspond to parasites that die in the early steps of infection, likely as the natural result of the host immunity overcoming mild infections.
authors: Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Jr. Ancash 1271, Barrios Altos, Lima 1, Peru. hgarcia@jhsph.edu
authors: H H
authors: HH
authors: García
authors: A E
authors: AE
authors: Gonzalez
authors: S
authors: S
authors: Rodriguez
authors: V C W
authors: VC
authors: Tsang
authors: E J
authors: EJ
authors: Pretell
authors: I
authors: I
authors: Gonzales
authors: R H
authors: RH
authors: Gilman
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D006099:Granuloma / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D020019:Neurocysticercosis / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D041201:Taenia solium / Q000472:pathogenicity; D014057:Tomography, X-Ray Computed / Q000379:methods