[Anticoagulant activity of extracts from cedar bark, anthocyanidins of spruce and birch bark, and cellulose of aspen, fir, and wheat straw].
We have investigated in vitro the anticoagulant (AC) activity of proanthocyanidins from the bark of birch, cedar, spruce, pine, and larch; sulfated arabinogalantan and dihydroquercetin from larch wood; extracts from birch, cedar, and spruce; microcrystalline cellulose (MCC) from aspen and fir wood and wheat straw; and methylcellulose (MC) from aspen wood. The AC properties of the investigated substances are related mostly to their antithrombin activity. The AC activity increases with the content of sulfur in MCC of wheat straw, MC of aspen wood, and arabinogalañtan of larch wood. The maximum AC activity was observed in samples of sulfated MCC from fir wood and wheat straw. Their antithrombin activity (134 +/- 8 and 96 +/- 6, respectively) is worth of carrying out model tests in vivo.
Drozd
N N
NN
Kuznetsova
S A
SA
Miftakhova
N T
NT
Makarov
V A
VA
Vasil'eva
N Iu
NIu
Levdanskiĭ
A V
AV
Butylkina
A I
AI
D028202:Abies / Q000737:chemistry*; D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D000991:Antithrombins / Q000737:chemistry / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D028203:Cedrus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D028222:Picea / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D014908:Triticum / Q000737:chemistry*
D000872:Anthocyanins; D000925:Anticoagulants; D000991:Antithrombins; D010936:Plant Extracts; D011794:Quercetin; C003377:taxifolin