Preparation of novel beta-cyclodextrin functionalized monolith and its application in chiral separation.
A novel beta-cyclodextrin (beta-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-beta-CD (EDA-beta-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was performed to confirm the homogeneity of the monolithic polymer. The resulting monolith was then characterized by DSC and XPS elemental analysis to study the thermal stability of the monolith, and to prove the successful immobilization of beta-CD on the polymer substrate. The beta-CD ligand density of 0.68 mmol g(-1) was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-beta-CD modifier. The ethylenediamine-beta-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results.
Lv
Yongqin
Y
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. yongqinlv@sina.com
Mei
Danping
D
Pan
Xinxin
X
Tan
Tianwei
T
D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005021:Ethylamines / Q000737:chemistry; D005026:Ethylene Glycols; D005029:Ethylenediamines / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry*
D005021:Ethylamines; D005026:Ethylene Glycols; D005029:Ethylenediamines; D008689:Methacrylates; D047392:beta-Cyclodextrins; C526534:poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate); C031234:ethylenediamine; C031215:betadex; C016162:triethylamine; D007052:Ibuprofen; D000432:Methanol