Multifunctional hybrid nanogel for integration of optical glucose sensing and self-regulated insulin release at physiological pH.
Optical detection of glucose, high drug loading capacity, and self-regulated drug delivery are simultaneously possible using a multifunctional hybrid nanogel particle under a rational design in a colloid chemistry method. Such hybrid nanogels are made of Ag nanoparticle (NP) cores covered by a copolymer gel shell of poly(4-vinylphenylboronic acid-co-2-(dimethylamino)ethyl acrylate) [p(VPBA-DMAEA)]. The introduction of the glucose sensitive p(VPBA-DMAEA) gel shell onto Ag NPs makes the polymer-bound Ag NPs responsive to glucose. While the small sized Ag cores (10 +/- 3 nm) provide fluorescence as an optical code, the responsive polymer gel shell can adapt to a surrounding medium of different glucose concentrations over a clinically relevant range (0-30 mM), convert the disruptions in homeostasis of glucose level into optical signals, and regulate release of preloaded insulin. This shows a new proof-of-concept for diabetes treatment that exploits the properties from each building block of a multifunctional nano-object. The highly versatile multifunctional hybrid nanogels could potentially be used for simultaneous optical diagnosis, self-regulated therapy, and monitoring of the response to treatment.
Wu
Weitai
W
Department of Chemistry, College of Staten Island of The City University of New York, 2800 Victory Boulevard, Staten Island, New York 10314, USA.
Mitra
Nivedita
N
Yan
Elsa C Y
EC
Zhou
Shuiqin
S
D000179:Acrylates / Q000737:chemistry; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D001897:Boronic Acids / Q000737:chemistry; D019556:COS Cells; D002522:Chlorocebus aethiops; D005947:Glucose / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000378:metabolism*; D008163:Luminescent Measurements; D053768:Metal Nanoparticles / Q000737:chemistry; D008744:Methylamines / Q000737:chemistry; D000080385:Nanogels; D036103:Nanotechnology / Q000379:methods*; D055620:Optical Phenomena; D010316:Particle Size; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000633:toxicity; D011094:Polyethyleneimine / Q000737:chemistry* / Q000633:toxicity; D012834:Silver / Q000737:chemistry; D013696:Temperature
C509606:2-(dimethylamino ethyl)acrylate; D000179:Acrylates; D001897:Boronic Acids; D007328:Insulin; D008744:Methylamines; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D012834:Silver; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D005947:Glucose