title: The relationships between cyclin D1 expression and prognosis of non-small cell lung cancer.
abstract: OBJECTIVE
  cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis. We performed a retrospective study on the cyclin D1 expression in non-small cell lung cancer (NSCLC) according to the clinical characteristics.
  
  
  METHODS
  One hundred fifteen postsurgical NSCLC patients were investigated. Immunohistochemistry was used to evaluate the cyclin D1 expression.
  
  
  RESULTS
  Overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1 low expression of tumors (Chi-square=5.132, P=0.023). In early stage patients (stage I, II), the overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1-low expression of tumors (Chi-square=6.863, P=0.009). cyclin D1 status (hazard ratio=0.630; P=0.035), differentiation (hazard ratio=0.399; P<0.001), and pTNM (hazard ratio=1.576; P<0.001) to be independent prognostic factors for NSCLC patients. Specifically, the cyclin D1 status (hazard ratio=0.188; P=0.008) was a significant prognostic factor for patients with stage I NSCLCs.
  
  
  CONCLUSIONS
  cyclin D1 expression is an independent prognosis factor for postoperative patient in stage I, II NSCLCs.
authors: Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing University School of Medicine, Nanjing 210029, China.
authors: Jiping
authors: J
authors: Zhu
authors: Like
authors: L
authors: Yu
authors: Ping
authors: P
authors: Zhan
authors: Yong
authors: Y
authors: Song
authors: Qin
authors: Q
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D019938:Cyclin D1 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019938:Cyclin D1