title: Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers.
abstract: Colombia is a country with great geographic heterogeneity and marked regional differences in pre-Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X-Chromosome), maternal (mtDNA), and paternal (Y-chromosome) markers. Autosomal ancestry varies markedly both within and between regions, confirming the great genetic diversity of the Colombian population. The X-chromosome, mtDNA, and Y-chromosome data indicate that there is a pattern across regions indicative of admixture involving predominantly Native American women and European and African men.
authors: Laboratory of Molecular Genetics, Institute of Biology, University of Antioquia, Medellín, Colombia. winstonrojas@yahoo.com
authors: Winston
authors: W
authors: Rojas
authors: María Victoria
authors: MV
authors: Parra
authors: Omer
authors: O
authors: Campo
authors: María Antonieta
authors: MA
authors: Caro
authors: Juan Guillermo
authors: JG
authors: Lopera
authors: William
authors: W
authors: Arias
authors: Constanza
authors: C
authors: Duque
authors: Andrés
authors: A
authors: Naranjo
authors: Jharley
authors: J
authors: García
authors: Candelaria
authors: C
authors: Vergara
authors: Jaime
authors: J
authors: Lopera
authors: Erick
authors: E
authors: Hernandez
authors: Ana
authors: A
authors: Valencia
authors: Yuri
authors: Y
authors: Caicedo
authors: Mauricio
authors: M
authors: Cuartas
authors: Javier
authors: J
authors: Gutiérrez
authors: Sergio
authors: S
authors: López
authors: Andrés
authors: A
authors: Ruiz-Linares
authors: Gabriel
authors: G
authors: Bedoya
mesh_terms: D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D003105:Colombia; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D005828:Genetics, Population / Q000379:methods*; D005843:Geography; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D044469:Racial Groups / Q000235:genetics*; D012737:Sex Factors
chemical_list: D004272:DNA, Mitochondrial; D005819:Genetic Markers