title: How to follow up advanced-stage borderline tumours? Mode of diagnosis of recurrence in a large series stage II-III serous borderline tumours of the ovary.
abstract: BACKGROUND
  The aim of this study was to describe how recurrences were diagnosed in the largest series of patients treated for an advanced-stage serous borderline ovarian tumour.
  
  
  METHODS
  From 1973 to 2006, 45 patients with a serous borderline tumour and peritoneal implants relapsed among 162 patients with a follow-up exceeding 1 year. Data concerning recurrences and the mode of diagnosis were reviewed.
  
  
  RESULTS
  The median follow-up interval was 8.2 years (range 19-286 months). The mode of diagnosis of recurrences was imaging (n = 19), clinical symptoms (n = 8), cancer antigen (CA) 125 elevation (n = 7), secondary surgery (n = 5) and unknown (n = 6). The median time to recurrence was 31 months (range 4-242 month). The type of recurrence was invasive low-grade serous carcinoma in 14 patients. Five patients died of recurrent tumour. Among the 39 patients with a known mode of diagnosis of recurrence, the most frequent diagnostic method for invasive recurrences was blood CA 125 elevation (6 of 13) and the majority of noninvasive recurrences were diagnosed by imaging (16 of 23).
  
  
  CONCLUSIONS
  This study demonstrates that ultrasound is the most relevant follow-up procedure in this context. Nevertheless, the blood CA 125 test is of particular interest for detecting invasive recurrent disease, which is the most crucial event.
authors: Department of Gynecologic Surgery.
authors: C
authors: C
authors: Uzan
authors: Department of Gynecologic Surgery.
authors: A
authors: A
authors: Kane
authors: Department of Biostatistics.
authors: A
authors: A
authors: Rey
authors: Department of Gynecologic Surgery.
authors: S
authors: S
authors: Gouy
authors: Department of Medical Oncology.
authors: P
authors: P
authors: Pautier
authors: Department of Medical Oncology.
authors: C
authors: C
authors: Lhomme
authors: Department of Pathology, Institut Gustave Roussy.
authors: P
authors: P
authors: Duvillard
authors: Department of Gynecologic Surgery; Department of University Paris Sud, Villejuif, France. Electronic address: morice@igr.fr.
authors: P
authors: P
authors: Morice
mesh_terms: D019937:Diagnostic Techniques and Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000401:mortality; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology