Molecular pathology in forensic medicine--Introduction.
Techniques of molecular biology have improved diagnostic sensitivity, accuracy and validity in forensic medicine very much, especially in the field of identification (paternity testing, stain analysis). Since more than 10 years these techniques - meanwhile well established in clinical disciplines - are used also for other applications in forensic medicine: determination of cause and manner of death, tissue identification by mRNA and microRNA, examination of gene expression levels (survival time, time since death, cause of death), toxicogenetics.
Madea
Burkhard
B
Institute of Forensic Medicine, University of Bonn, Bonn, Germany. b.madea@uni-bonn.de
Saukko
Pekka
P
Oliva
Antonio
A
Musshoff
Frank
F
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000236:Adenoma / Q000235:genetics / Q000473:pathology; D000465:Algorithms; D001706:Biopsy; D001801:Blood Stains; D001826:Body Fluids; D001921:Brain / Q000378:metabolism; D002423:Cause of Death; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology; D003141:Communicable Diseases / Q000175:diagnosis / Q000235:genetics; D056146:Corpse Dismemberment; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D016757:Death, Sudden, Cardiac; D005260:Female; D053803:Forensic Genetics; D049429:Forensic Pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D035683:MicroRNAs / Q000378:metabolism; D009154:Mutation; D010597:Pharmacogenetics; D010819:Physician's Role; D011041:Poisoning / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011180:Postmortem Changes; D012313:RNA / Q000235:genetics; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000378:metabolism; D020080:Tandem Repeat Sequences; D014947:Wounds and Injuries / Q000473:pathology
D004269:DNA, Bacterial; D004279:DNA, Viral; D035683:MicroRNAs; D012333:RNA, Messenger; D017450:Receptors, Opioid, mu; D012313:RNA