title: Factors influencing left ventricular mass regression in patients with primary aldosteronism post adrenalectomy.
abstract: BACKGROUND
  Primary aldosteronism (PA) is a type of secondary hypertension with prominent left ventricular hypertrophy (LVH). Unilateral aldosterone-producing adenoma (APA) is the most common subtype that can be cured by adrenalectomy.
  
  
  OBJECTIVE
  To investigate left ventricular structural change after surgery and the factors associated with the degree of LVH regression in patients with PA.
  
  
  METHODS
  We performed a retrospective analysis in the Taiwan Primary Aldosteronism Investigation (TAIPAI) database, including demography, biochemical data, echocardiography and medication.
  
  
  RESULTS
  From July 1994 to January 2007, 20 patients (8 men) with APA receiving adrenalectomy and having pre- and postoperative echocardiography were selected. After 21 ± 19 months post operation, the left ventricular wall thickness and left ventricular mass index (LVMI) decreased significantly. The decrease of LVMI is significant only in patients who had LVH before operation. In analysis of factors associated with net LVMI decrease (ΔLVMI; post-operative LVMI - pre-operative LVMI), only pre-operative LVMI (r = -.783, p < .001), and ΔSBP (r = .472, p = .036) significantly correlated with ΔLVMI. In conclusion, LVH in PA could be significantly reversed by adrenalectomy. Pre-operative LVMI and ΔSBP were associated with the degree of LVMI decrease.
  
  
  CONCLUSIONS
  LVH in PA could be significantly reversed by adrenalectomy. Pre-operative LVMI and ΔSBP were associated with the degree of LVMI decrease.
authors: National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors: Yen-Hung
authors: YH
authors: Lin
authors: Kuo-How
authors: KH
authors: Huang
authors: Jen-Kuang
authors: JK
authors: Lee
authors: Shuo-Meng
authors: SM
authors: Wang
authors: Ruoh-Fang
authors: RF
authors: Yen
authors: Vin-Cent
authors: VC
authors: Wu
authors: Shiu-Dong
authors: SD
authors: Chung
authors: Kao-Lang
authors: KL
authors: Liu
authors: Shih-Chieh
authors: SC
authors: Chueh
authors: Lian-Yu
authors: LY
authors: Lin
authors: Yi-Lwun
authors: YL
authors: Ho
authors: Ming-Fong
authors: MF
authors: Chen
authors: Kwan-Dun
authors: KD
authors: Wu
mesh_terms: D000315:Adrenalectomy; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography