[Effects of alcohol on acute myocardial ischemia induced by pituitrin in rats].
OBJECTIVE
To observe the effects of alcohol intake at different levels on acute myocardial ischemia induced by pituitrin in rats.


METHODS
Forty SD male rats were randomly divided into five groups, including model control group (pituitrin, 1U/kg), positive control group (verapamil, 1 mg/kg), 5% alcohol group (0.4 g/kg), 10% alcohol group (0.8 g/kg) and 20% alcohol group (1.6 g/kg). Myocardial ischemia model was made in rats by injecting pituitrin (1U/kg) through sublingual vein. The heart rate, incidence of arrhythmia, the changes of ST segment and T wave on electrocardiogram of rats were observed and compared.


RESULTS
The incidence of arrhythmia, the degree of elevated ST segment and T wave amplitude induced by pituitrin were remitted obviously in the 5% alcohol group (0.4 g/kg); The heart rate was slower and the change of ST segment and T wave were not affected in the 10% alcohol group (0.8 g/kg). The heart rate was slower and the elevated ST segment and the T wave amplitude were augmented significantly in the 20% alcohol group (1.6 g/kg).


CONCLUSIONS
A protective effect on acute myocardial ischemia induced by pituitrin in rats was shown in the 5% alcohol group (0.4 g/kg) and an aggravation of acute myocardial ischemia induced by pituitrin was observed in the 20% alcohol group (1.6 g/kg).
He
Huikang
H
College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Tang
Mengjie
M
Wang
Xinghui
X
Du
Kexin
K
Zu
Chao
C
Zang
Weijin
W
Hu
Hao
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000188:drug therapy*; D010909:Pituitary Hormones, Posterior; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D010909:Pituitary Hormones, Posterior; D000431:Ethanol