title: Evolution of GPCR: change and continuity.
abstract: Once introduced into the very early eukaryotic blueprint, seven-transmembrane receptors soon became the central and versatile components of the evolutionary highly successful G protein-coupled transmembrane signaling mechanism. In contrast to all other components of this signal transduction pathway, G protein-coupled receptors (GPCR) evolved in various structural families, eventually comprising hundreds of members in vertebrate genomes. Their functional diversity is in contrast to the conserved transmembrane core and the invariant set of intracellular signaling mechanisms, and it may be the interplay of these properties that is the key to the evolutionary success of GPCR. The GPCR repertoires retrieved from extant vertebrate genomes are the recent endpoints of this long evolutionary process. But the shaping of the fine structure and the repertoire of GPCR is still ongoing, and signatures of recent selection acting on GPCR genes can be made visible by modern population genetic methods. The very dynamic evolution of GPCR can be analyzed from different perspectives: at the levels of sequence comparisons between species from different families, orders and classes, and at the level of populations within a species. Here, we summarize the main conclusions from studies at these different levels with a specific focus on the more recent evolutionary dynamics of GPCR.
authors: Institute of Biochemistry, Medical Faculty, University of Leipzig, Germany. rainer.strotmann@medizin.uni-leipzig.de
authors: Rainer
authors: R
authors: Strotmann
authors: Kristin
authors: K
authors: Schröck
authors: Iris
authors: I
authors: Böselt
authors: Claudia
authors: C
authors: Stäubert
authors: Andreas
authors: A
authors: Russ
authors: Torsten
authors: T
authors: Schöneberg
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled