title: Anti-allergic activity of a platycodon root ethanol extract.
abstract: Platycodon grandiflorum (Campanulaceae) is used as traditional medicine in Asian countries. In Korean traditional medicine, Platycodon root has been widely used since ancient times as a traditional drug to treat cold, cough and asthma. However, its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms remain unknown. In this study, the biological effect of Platycodon root ethanol extract (PE) was evaluated in BMMC after induction of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187) stimulation. The effect of PE on the production of several allergic mediators, such as interleukin-6 (IL-6), prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), beta-Hexosaminidase (beta-Hex) and cyclooxygenase-2 (COX-2) protein, was investigated. The results demonstrate that PE inhibits PMA + A23187 induced production of IL-6, PGD(2), LTC(4), beta-Hexosaminidase and COX-2 protein. Taken together, these results indicate that PE has the potential for use in the treatment of allergy.
authors: College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan 570-749, Korea; E-Mails: ulivuli@hanmail.net (Y.-C.O.); kangokhwa@hanmail.net (O.-H.K.); JJ0038@wku.ac.kr (J.-G.C.); st_andrea81@naver.com (Y.-S.L.); b_obiang@yahoo.com (O.-O.B.); hyun104@wku.ac.kr (H.J.J.); jooklim@wku.ac.kr (S.-H.H); ymlee@wku.ac.kr (Y.-M.L.).
authors: You-Chang
authors: YC
authors: Oh
authors: Ok-Hwa
authors: OH
authors: Kang
authors: Jang-Gi
authors: JG
authors: Choi
authors: Young-Seob
authors: YS
authors: Lee
authors: Obiang-Obounou
authors: OO
authors: Brice
authors: Hyun Ju
authors: HJ
authors: Jung
authors: Seung-Heon
authors: SH
authors: Hong
authors: Young-Mi
authors: YM
authors: Lee
authors: Dong-Won
authors: DW
authors: Shin
authors: Yeong-Shik
authors: YS
authors: Kim
authors: Dong-Yeul
authors: DY
authors: Kwon
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D015550:Cell Degranulation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D017997:Leukotriene C4 / Q000096:biosynthesis; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D031238:Platycodon / Q000737:chemistry*; D015230:Prostaglandin D2 / Q000096:biosynthesis
chemical_list: D018926:Anti-Allergic Agents; D015850:Interleukin-6; D010936:Plant Extracts; D017997:Leukotriene C4; D051546:Cyclooxygenase 2; D015230:Prostaglandin D2