title: [Expression of peroxiredoxin III in cervical lesions].
abstract: OBJECTIVE
  To investigate the expression feature of peroxiredoxin III in cervical lesions and to further understand the mechanism for cervical cancer development/progression.
  
  
  METHODS
  Expression of peroxiredoxin III was immunohistochemically detected in cervical cancer. In addition, cervical epithelia were transfected with recombinant adeno-associated virus vector containing human papillomavirus 16 E6/E7 and peroxiredoxin III expression was detected by quantitative real time PCR and Western blotting.
  
  
  RESULTS
  Peroxiredoxin III was significantly up-regulated in cervical cancer tissues. Nevertheless, expression of peroxiredoxin III remained unchanged in cervical epithelial cells after transfection.
  
  
  CONCLUSIONS
  It seems that Prx III is not related to cervical cancer initiation. Up-regulation of peroxiredoxin III in cervical cancer might be an active response to oxidative stress in malignant cells, which protects against oxidatiton-induced apoptosis.
authors: Obstetrics and Gynecology Center, Tsinghua University Second Hospital, Beijing, China.
authors: Lian-qin
authors: LQ
authors: Li
authors: Chun-ling
authors: CL
authors: Chen
authors: Ze-yi
authors: ZY
authors: Cao
authors: Qin-ping
authors: QP
authors: Liao
authors: Hai-jun
authors: HJ
authors: Du
authors: Shao-bing
authors: SB
authors: Zhan
authors: Ling
authors: L
authors: Zhou
authors: Yi
authors: Y
authors: Zeng
mesh_terms: D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D052162:Human papillomavirus 16 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D050725:Papillomavirus E7 Proteins / Q000235:genetics / Q000378:metabolism; D054464:Peroxiredoxins / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000821:virology
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16; D054464:Peroxiredoxins