Development of a new Lewis base-tolerant chiral LBA and its application to catalytic asymmetric protonation reaction.
A new Lewis base-tolerant LBA (Lewis Acid Assisted Brønsted Acid) derived from La(OTf)(3) and (S)-HOP has been developed as a new chiral Brønsted acid. This acid has been successfully applied as a catalyst to asymmetric protonation reactions of silyl enol ethers of 2-substituted cyclic ketones.
Cheon
Cheol Hong
CH
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60615, USA.
Imahori
Tatsushi
T
Yamamoto
Hisashi
H
D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D007811:Lanthanum / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011522:Protons; D013237:Stereoisomerism
C554117:(S)-2-hydroxy-2'-diphenylphosphino-1,1'-binaphthyl; D007659:Ketones; D009281:Naphthalenes; D009942:Organometallic Compounds; D011522:Protons; D007811:Lanthanum