Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula.
A 24-methylenecycloartane-3 β, 16 β, 23 β-triol, Longitriol (1), rare bisclerodane imides, Longimide A (2) and previously known Longimide B (3) were isolated from ethanolic extract of the leaves of Polyalthia longifolia var. pendula. This is the first example of isolation of any cycloartane triterpene from this plant source. Structures were determined by extensive (1D and 2D NMR) spectroscopic data analysis combined with ESI MS/MS fragmentation and X-ray analysis. Furthermore, Compounds 1 and 2 were evaluated for their cytotoxic effects against four human cancer cell lines and found to be most active against cervical carcinoma cell lines with IC(50) value of 10.03 and 4.12 μg/mL, respectively.
Sashidhara
Koneni V
KV
Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
Singh
Suriya P
SP
Kant
Ruchir
R
Maulik
Prakas R
PR
Sarkar
Jayanta
J
Kanojiya
Sanjeev
S
Ravi Kumar
K
K
D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D031044:Polyalthia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C555994:24-methylenecycloartane-3beta,16beta,23beta-triol; D004224:Diterpenes; D014315:Triterpenes; C555995:longimide A; C085352:cycloartane