Uncovering the roles of PINK1 and parkin in mitophagy.
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder, and thus elucidation of the pathogenic mechanism and establishment of a fundamental cure is essential in terms of public welfare. Fortunately, our understanding of the pathogenesis of two types of recessive familial PDs--early-onset familial PD caused by dysfunction of the PTEN induced putative kinase 1 (PINK1) gene and autosomal recessive juvenile Parkinsonism (ARJP) caused by a mutation in the Parkin gene--has evolved and continues to expand.
Matsuda
Noriyuki
N
Protein metabolism project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan. matsuda-nr@igakuken.or.jp
Tanaka
Keiji
K
D001343:Autophagy / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000473:pathology*; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D020734:Parkinsonian Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism; D000099202:PTEN-Induced Putative Kinase
D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein