Postoperative parathyroid hormone testing decreases symptomatic hypocalcemia and associated emergency room visits after total thyroidectomy.
BACKGROUND
Symptomatic hypocalcemia, the most common complication of total thyroidectomy, can lead to postoperative emergency room visits for laboratory testing and intravenous calcium infusion. A method to identify patients reliably at risk for postoperative hypocalcemia could allow prophylactic treatment to avoid this. We hypothesized that quick parathyroid hormone testing within 4 hours of thyroidectomy and a protocol to treat parathyroid-hormone-deficient patients would reduce symptomatic hypocalcemia, eliminating the need for emergency room visits.


METHODS
After January 1, 2006, 271 consecutive patients underwent total thyroidectomy with postoperative parathyroid hormone testing (group 1). Patients with parathyroid hormone levels <10 pg/mL were treated according to a newly instituted protocol with 0.25-ug calcitriol twice daily and 2-6 g of calcium carbonate daily for 1 week. Patients with parathyroid hormone levels ≥10 pg/mL were treated with calcium only. Group 2 consisted of 100 consecutive patients who underwent total thyroidectomy prior to 2006 without parathyroid hormone testing and were treated according to surgeon preference and serum calcium levels.


RESULTS
Patients in the 2 groups were similar with regard to age, sex, and thyroiditis. However, patients in group 1, who had parathyroid hormone testing, had greater postoperative calcium levels (P < .005). Also, patients in group 2 had a higher incidence of malignancy (P = .04). Importantly, patients in group 1 had a lesser incidence of symptomatic hypocalcemia (7% vs 17%; P = .005). Furthermore, the number of patients who made visits to the emergency room was less in patients who had parathyroid hormone testing compared with those who did not (1.8% vs 8.0%; P = .008).


CONCLUSIONS
Postoperative parathyroid hormone testing reliably identifies patients at risk for hypocalcemia after thyroid surgery. Moreover, parathyroid hormone testing and calcitriol administration to patients at risk decreases the incidence of hypocalcemia and associated emergency room visits after total thyroidectomy. Therefore, patients with postoperative serum parathyroid hormone levels <10 pg/mL after thyroid surgery should be treated with calcitriol and calcium to prevent symptomatic hypocalcemia.
Youngwirth
Linda
L
Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792-7375, USA.
Benavidez
Joy
J
Sippel
Rebecca
R
Chen
Herbert
H
D000328:Adult; D002117:Calcitriol / Q000008:administration & dosage; D002119:Calcium Carbonate / Q000008:administration & dosage; D002120:Calcium Channel Agonists / Q000008:administration & dosage; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011184:Postoperative Period; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects*
D002120:Calcium Channel Agonists; D010281:Parathyroid Hormone; D002117:Calcitriol; D002119:Calcium Carbonate