title: Relationship between the serum CA-125 level and bone mineral density in healthy pre- and post-menopausal women.
abstract: BACKGROUND
  Osteoporosis and tumour-associated antigen (TAA) levels are associated with inflammatory processes, but little remains known about TAA levels and bone mineral density (BMD).
  
  
  OBJECTIVE
  We determined whether or not high-normal TAA levels are associated with a lower BMD in healthy women.
  
  
  METHODS
  A total of 3769 healthy women were enrolled from the health screening programme over 5 years. Each participant had undergone a basic health examination. Serum carbohydrate antigen (CA)-125, CA-19-9, carcinoembryonic antigen (CEA) and alpha-fetoprotein levels were evaluated as tumour markers. The correlations between serum TAA levels and BMD were analysed.
  
  
  RESULTS
  Carbohydrate antigen 125 and CEA levels were positively associated with a higher BMD in the pre-menopause. In the post-menopause, the CA-125 level was positively associated with BMD. In the pre-menopause, CA-125 (r = 0.102; P < 0.001) and CEA levels (r = 0.134; P < 0.001) had a significant correlation with BMD. In the post-menopause, CA-125 was negatively associated with alkaline phosphatase (r = -0.298; P < 0.001).
  
  
  CONCLUSIONS
  There was a significant positive association between CA-125 and BMD in healthy women. Additional basic and clinical studies on the relationship between CA-125 and bone are needed.
authors: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
authors: Ki Hoon
authors: KH
authors: Ahn
authors: Hyun Tae
authors: HT
authors: Park
authors: Tak
authors: T
authors: Kim
authors: Jun Young
authors: JY
authors: Hur
authors: Young Tae
authors: YT
authors: Kim
authors: Kyu Wan
authors: KW
authors: Lee
authors: Sun Haeng
authors: SH
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000276:immunology / Q000378:metabolism*; D017697:Premenopause / Q000276:immunology / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000096:biosynthesis
chemical_list: D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins