title: Study of DSM-IV Axis I psychiatric disorders in patients with refractory complex partial seizures using a short structured clinical interview.
abstract: Psychiatric disorders are a source of significant comorbidity in patients with refractory epilepsy, yet are often underrecognized. We assessed the prevalence of DSM-IV Axis I psychiatric disorders using a short structured clinical interview (Mini-International Psychiatric Interview [MINI]) in patients with medically refractory complex partial seizures. Consecutive patients with refractory epilepsy being evaluated with video/EEG monitoring and imaging for seizure focus localization and lateralization underwent MINI evaluation to assess for the presence of psychiatric disorders. Among 117 patients (74 male, 43 female) studied, 57 (48.7%) had at least one psychiatric disorder; 19 (16.2%) had depression, 10 (8.5%) dysthymia, 27 (23.0%) anxiety disorder, and 11(9.4%) other disorders. Most clinical features and epilepsy-related variables had no significant association with psychiatric disorder on logistic regression analysis. Almost half of the patients with refractory focal seizures have a coexistent psychiatric disorder, and its presence or absence cannot be predicted by their clinical profiles. All patients should be assessed and treated for psychiatric comorbidity to improve overall quality of life.
authors: Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
authors: Soaham D
authors: SD
authors: Desai
authors: Garima
authors: G
authors: Shukla
authors: Vinay
authors: V
authors: Goyal
authors: Sumit
authors: S
authors: Singh
authors: M V
authors: MV
authors: Padma
authors: Manjari
authors: M
authors: Tripathi
authors: Achal
authors: A
authors: Srivastava
authors: Mamta
authors: M
authors: Singh
authors: K
authors: K
authors: Shivakumar
authors: Rajesh
authors: R
authors: Sagar
authors: Madhuri
authors: M
authors: Behari
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D017029:Epilepsy, Complex Partial / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013223:Statistics as Topic; D055815:Young Adult