[Molecular pathology of thyroid tumors].
Molecular genetic analysis is gaining in significance for the differential diagnosis of thyroid tumours. Identifying specific mutations and/or rearrangements offers not only the possibility to distinguish benign from malignant tumours, but also to classify thyroid malignancies more precisely, which can have a substantial influence on the clinical management of patients. In recent years expression analysis of micro-RNA (miRNA) has become an additional tool to improve diagnostic accuracy in thyroid tumours. In addition to its diagnostic contribution, molecular genetic evaluation of thyroid tumours has significantly deepened our understanding of the development, progression and therapy of these tumours.
Schmid
K W
KW
Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147 Essen. kw.schmid@uk-essen.de
D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D065646:Thyroid Carcinoma, Anaplastic; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D013965:Thyroidectomy
D035683:MicroRNAs