Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection.
A critical factor influencing the ability of the host to mount a robust immune response against a virus depends on the rapid recruitment of dendritic cells (DCs) presenting Ags. From the outset, this step sets the tempo for subsequent activation of virus-specific T cells. Despite this, how induction of the immune response might be modified by pathogens with the capacity to establish persistence is unclear. In this study, we have characterized the in vivo influence of murine gamma-herpesvirus K3-mediated interference with MHC class I in DCs that drive the initial adaptive immune response. We observed that gamma-herpesvirus could interfere with the very earliest phase of Ag presentation through K3 by directly targeting migratory and lymph node-resident DCs. These results show that a pathogen with the capacity to interfere with early Ag presentation can establish suboptimal conditions for rapid induction of the adaptive immune response and thus favor establishment of viral persistence.
Mount
Adele M
AM
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Masson
Frederick
F
Kupresanin
Fiona
F
Smith
Christopher M
CM
May
Janet S
JS
van Rooijen
Nico
N
Stevenson
Philip G
PG
Belz
Gabrielle T
GT
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D002908:Chronic Disease; D045142:Cross-Priming / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006566:Herpesviridae Infections / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018144:Rhadinovirus / Q000276:immunology* / Q000472:pathogenicity; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000821:virology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000378:metabolism; D014762:Viral Interference / Q000276:immunology; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis
C456022:K3 protein, Kaposi's sarcoma-associated herpesvirus; D014764:Viral Proteins