[Gene expression profile of human cumulus cells: clinical applications for IVF].
Genes expression profile of cumulus cells which surrounds oocyte correlated to different outcomes, allowing the identification of a specific expression signature of embryos developing towards pregnancy. Interestingly, genes in cumulus samples resulting in a successful pregnancy were predominantly up-regulated, including BCL2L11 and PCK1, respectively involved in apoptosis and gluconeogenesis. Some genes were nevertheless found down regulated in cumulus cells associated with a good pregnancy outcome, such as the transcription factor NFIB.
Hamamah
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Hôpital Arnaud de Villeneuve, Centre Fécondation In Vitro et DPI, 371, Avenue Du Doyen Gaston Giraud 34295, Montpellier, France.
Fallet
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C
D017209:Apoptosis / Q000235:genetics; D051017:Apoptosis Regulatory Proteins / Q000235:genetics; D000072224:Bcl-2-Like Protein 11; D054885:Cumulus Cells / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D020869:Gene Expression Profiling; D005943:Gluconeogenesis / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D015854:Up-Regulation
D051017:Apoptosis Regulatory Proteins; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; C521898:PCK1 protein, human; D010729:Phosphoenolpyruvate Carboxykinase (GTP)