Total regioselective control of tartaric acid.
An efficient strategy to synthesize tartaric acid building blocks for totally regioselective transformations or derivatizations was disclosed. Starting from l-tartaric acid or l-dimethyl tartrate, respectively, we obtained type I and II building blocks with orthogonal sets of protecing groups (4-8 steps, 38-56% overall yield).
Spengler
Jan
J
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. jan.spengler@irbbarcelona.org
Fernández-Llamazares
Ana I
AI
Ruiz-Rodríguez
Javier
J
Burger
Klaus
K
Albericio
Fernando
F
D008968:Molecular Conformation; D013237:Stereoisomerism; D013644:Tartrates / Q000138:chemical synthesis* / Q000737:chemistry
D013644:Tartrates; C029768:tartaric acid