title: Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
abstract: Herein we show that San A-amide, a structurally unique molecule, influences a subset of cancer-related pathways involving Hsp90. We show that San A-amide specifically binds to the N-middle domain of Hsp90 allosterically disrupts the binding of proteins thought to interact with the Hsp90 C-terminal domain, while having no effect on an N-terminal domain client protein. This unique mechanism suggests that San A-amide is a potential tool for studying C-terminal binding proteins of Hsp90 as well as a promising lead in the development of new cancer therapeutics.
authors: Department of Chemistry and Biochemistry, 5500 Campanile Road, San Diego State University, San Diego, CA 92182-1030.
authors: Robert C
authors: RC
authors: Vasko
authors: Rodrigo A
authors: RA
authors: Rodriguez
authors: Christian N
authors: CN
authors: Cunningham
authors: Veronica C
authors: VC
authors: Ardi
authors: David A
authors: DA
authors: Agard
authors: Shelli R
authors: SR
authors: McAlpine