Effective construction of quaternary stereocenters by highly enantioselective α-amination of branched aldehydes.
A highly efficient enantioselective α-amination of branched aldehydes with azadicarboxylates promoted by chiral proline-derived amide thiourea bifunctional catalysts was developed for the first time, affording the adducts bearing quaternary stereogenic centers with excellent yields (up to 99%) and enantioselectivities (up to 97% ee).
Fu
Ji-Ya
JY
Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China, PR.
Xu
Xiao-Ying
XY
Li
Yan-Chun
YC
Huang
Qing-Chun
QC
Wang
Li-Xin
LX