title: Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies.
abstract: A series of 2-benzyl-3-(2-arylidenehydrazinyl)quinoxalines 3, 4-benzyl-1-aryl-[1,2,4]triazolo[4,3-a]quinoxalines 4 and phenyl(1-aryl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)methanones 5 analogues were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. The inhibition profile was found to be competitive for compounds 3k, 3m, 5f and 5n with MAO-A selectivity. Observation of the docked positions of these compounds revealed interactions with many residues previously reported to have an effect on the inhibition of the enzyme. The structural features of the new compounds have been determined from the microanalytical, IR, (1)H, (13)C NMR spectral studies and X-ray crystalography.
authors: Department of Chemistry, Faculty of Science, P.O. Box 426 Ibrahimia, Alexandria University, Egypt.
authors: Sherine N
authors: SN
authors: Khattab
authors: Seham Y
authors: SY
authors: Hassan
authors: Adnan A
authors: AA
authors: Bekhit
authors: Abdel Moneim
authors: AM
authors: El Massry
authors: Vratislav
authors: V
authors: Langer
authors: Adel
authors: A
authors: Amer
mesh_terms: D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D006801:Humans; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000201:enzymology; D008958:Models, Molecular; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011485:Protein Binding; D011810:Quinoxalines / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats
chemical_list: D008996:Monoamine Oxidase Inhibitors; D011810:Quinoxalines; D008995:Monoamine Oxidase