title: Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe.
abstract: This study aimed to compare the discrimination accuracy of hippocampal volume (HC-Vol), parahippocampal cingulum fractional anisotropy (PHC-FA), hippocampal glucose metabolism (HC-Glu), and any combination of the three measurements among normal control (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). Three-dimensional MRI, diffusion tensor imaging, and FDG-PET were applied to age- and gender-matched 17 NC, 17 MCI, and 17 mild AD patients. Subjects also underwent a neuropsychological test battery including three verbal episodic memory tests. Logistic regression analyses were systematically conducted to select the best model for between-group discrimination. PHC-FA plus HC-Vol model, HC-Glu only model, and the model combining all three modalities were finally chosen for NC vs. MCI (discrimination accuracy: 79.4%), MCI vs. AD (73.5%), and NC vs. AD discrimination (94.1%), respectively. All the three imaging measures also showed significant correlation with all three episodic memory tests. These findings support that each imaging measure, respectively, and their combination have a stage-specific potential as a useful neuroimaging marker for detection and progression monitoring of early stage of AD.
authors: Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, Republic of Korea.
authors: Jin Hyeong
authors: JH
authors: Jhoo
authors: Dong Young
authors: DY
authors: Lee
authors: Il Han
authors: IH
authors: Choo
authors: Eun Hyun
authors: EH
authors: Seo
authors: Jungsu S
authors: JS
authors: Oh
authors: Jae Sung
authors: JS
authors: Lee
authors: Dong Soo
authors: DS
authors: Lee
authors: Shin Gyeom
authors: SG
authors: Kim
authors: Jong Chul
authors: JC
authors: Youn
authors: Ki Woong
authors: KW
authors: Kim
authors: Jong Inn
authors: JI
authors: Woo
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D000704:Analysis of Variance; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography / Q000379:methods; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*