Enantioselective syntheses of both enantiomers of cis-pyrrolidine 225H.
The efficient and expeditious syntheses of both enantiomers of the amphibian alkaloid cis-225H have been achieved. Utilizing a common cis-2,5-disubstituted pyrrolidine building block derived from (+)-2-tropinone, the enantioselective syntheses have established the absolute configuration of these alkaloids as (+)-(2R,5S) and (-)-(5S,2R).
Shu
Hong
H
Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA.
Noble
April R
AR
Zhang
Suhong
S
Miao
Lei
L
Trudell
Mark L
ML