title: A progressive 5-week exercise therapy program leads to significant improvement in knee function early after anterior cruciate ligament injury.
abstract: METHODS
  Prospective cohort study without a control group.
  
  
  OBJECTIVE
  Firstly, to present our 5-week progressive exercise therapy program in the early stage after anterior cruciate ligament (ACL) injury. Secondly, to evaluate changes in knee function after completion of the program for patients with ACL injury in general and also when classified as potential copers or noncopers, and, finally, to examine potential adverse events.
  
  
  BACKGROUND
  Few studies concerning early-stage ACL rehabilitation protocols exist. Consequently, little is known about the tolerance for, and outcomes from, short-term exercise therapy programs in the early stage after injury.
  
  
  METHODS
  One-hundred patients were included in a 5-week progressive exercise therapy program, within 3 months after injury. Knee function before and after completion of the program was evaluated from isokinetic quadriceps and hamstrings muscle strength tests, 4 single-leg hop tests, 2 different self-assessment questionnaires, and a global rating of knee function. A 2-way mixed-model analysis of variance was conducted to evaluate changes from pretest to posttest for the limb symmetry index for muscle strength and single-leg hop tests, and the change in scores for the patient-reported questionnaires. In addition, absolute values and the standardized response mean for muscle strength and single-leg hop tests were calculated at pretest and posttest for the injured and uninjured limb. Adverse events during the 5-week period were recorded.
  
  
  RESULTS
  The progressive 5-week exercise therapy program led to significant improvements (P<.05) in knee function from pretest to posttest both for patients classified as potential copers and noncopers. Standardized response mean values for changes in muscle strength and single-leg hop performance from pretest to posttest for the injured limb were moderate to strong (0.49-0.84), indicating the observed improvements to be clinically relevant. Adverse events occurred in 3.9% of the patients.
  
  
  CONCLUSIONS
  Short-term progressive exercise therapy programs are well tolerated and should be incorporated in early-stage ACL rehabilitation, either to improve knee function before ACL reconstruction or as a first step in further nonoperative management.
  
  
  METHODS
  Therapy, level 2b.
authors: Department of Orthopaedics, Oslo University Hospital, Oslo, Norway. ingrid.eitzen@hjelp24.no
authors: Ingrid
authors: I
authors: Eitzen
authors: Håvard
authors: H
authors: Moksnes
authors: Lynn
authors: L
authors: Snyder-Mackler
authors: May Arna
authors: MA
authors: Risberg
mesh_terms: D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000070598:Anterior Cruciate Ligament Injuries; D004185:Disability Evaluation; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000523:psychology / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D011446:Prospective Studies; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D016896:Treatment Outcome