Impaired speech repetition and left parietal lobe damage.
Patients with left hemisphere damage and concomitant aphasia usually have difficulty repeating others' speech. Although impaired speech repetition, the primary symptom of conduction aphasia, has been associated with involvement of the left arcuate fasciculus, its specific lesion correlate remains elusive. This research examined speech repetition among 45 stroke patients who underwent aphasia testing and MRI examination. Based on lesion-behavior mapping, the primary structural damage most closely associated with impaired speech repetition was found in the posterior portion of the left arcuate fasciculus. However, perfusion-weighted MRI revealed that tissue dysfunction, in the form of either frank damage or hypoperfusion, to the left inferior parietal lobe, rather than the underlying white matter, was associated with impaired speech repetition. This latter result suggests that integrity of the left inferior parietal lobe is important for speech repetition and, as importantly, highlights the importance of examining cerebral perfusion for the purpose of lesion-behavior mapping in acute stroke.
Fridriksson
Julius
J
Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208, USA. jfridrik@sc.edu
Kjartansson
Olafur
O
Morgan
Paul S
PS
Hjaltason
Haukur
H
Magnusdottir
Sigridur
S
Bonilha
Leonardo
L
Rorden
Christopher
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D007839:Functional Laterality; D006801:Humans; D007100:Imitative Behavior / Q000502:physiology*; D007807:Language Tests; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology; D010296:Parietal Lobe / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D012720:Severity of Illness Index; D013060:Speech / Q000502:physiology*; D020521:Stroke / Q000473:pathology / Q000503:physiopathology*