title: Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
abstract: A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
authors: Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
authors: Jiming
authors: J
authors: Zhang
authors: Sheng
authors: S
authors: Li
authors: Dehui
authors: D
authors: Zhang
authors: Hua
authors: H
authors: Wang
authors: A Richard
authors: AR
authors: Whorton
authors: Ming
authors: M
authors: Xian
mesh_terms: D004220:Disulfides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*
chemical_list: D004220:Disulfides; D010720:Phosphines; D026403:S-Nitrosothiols; C044646:phosphine