title: Clinical significance of pmTOR expression in endometrioid endometrial carcinoma.
abstract: OBJECTIVE
  Endometrial adenocarcinoma has been proposed, due to frequent activation of the PI3K/AKT pathway, as a candidate neoplasm for treatment with mTOR inhibitors. However, data on the expression of mTOR in endometrial cancer are lacking.
  
  
  METHODS
  We used immunohistochemistry to evaluate the expression of pmTOR in 62 endometrial cancer surgical specimens.
  
  
  RESULTS
  The pmTOR protein was diffusely expressed in the cytoplasm of neoplastic epithelial cells, showing variable intensity. According to the chosen cutoff value, 34 (54.8%) out of 62 patients were scored as pmTOR-positive. pmTOR expression was significantly decreased in carcinomas with deep infiltration into the myometrium (P=.009), though it was not correlated with disease stage or lymph node metastasis. Univariate analysis showed that increased expression of pmTOR was significantly associated with better disease-free survival (P=.021).
  
  
  CONCLUSIONS
  We show for the first time an association between pmTOR and better survival in patients with endometrial cancer. Future studies to stratify endometrial tumors by pmTOR status are needed.
authors: Department of Obstetrics & Gynecology, Samsung Medical Center, Seoul, Republic of Korea.
authors: Chel Hun
authors: CH
authors: Choi
authors: Ji-Soo
authors: JS
authors: Lee
authors: Seong Rim
authors: SR
authors: Kim
authors: Tae-Joong
authors: TJ
authors: Kim
authors: Jeong-Won
authors: JW
authors: Lee
authors: Byoung-Gie
authors: BG
authors: Kim
authors: Duk-Soo
authors: DS
authors: Bae
mesh_terms: D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D058570:TOR Serine-Threonine Kinases / Q000096:biosynthesis*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases