title: Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain.
abstract: We recently demonstrated that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain to induce digestive neoplasia in dexamethasone-treated SCID mice was explored. SCID mice infected with C. parvum TUM1 strain developed a fulminant cryptosporidiosis associated with intramucosal adenocarcinoma, which is considered an early histological sign of invasive cancer. Both evidence of a role of C. parvum in adenocarcinoma induction and the extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum-induced gastro-intestinal cancer in humans should be assessed.
authors: Laboratoire Biologie et Diversité des Pathogènes Eucaryotes Emergents (BDEEP), Institut Pasteur de Lille (IFR 142)-Université Lille Nord de France (EA4547), Lille, France. gabriela.certad@pasteur-lille.fr
authors: Gabriela
authors: G
authors: Certad
authors: Colette
authors: C
authors: Creusy
authors: Karine
authors: K
authors: Guyot
authors: Anthony
authors: A
authors: Mouray
authors: Thierry
authors: T
authors: Chassat
authors: Baptiste
authors: B
authors: Delaire
authors: Anthony
authors: A
authors: Pinon
authors: Ariadna
authors: A
authors: Sitja-Bobadilla
authors: Pilar
authors: P
authors: Alvarez-Pellitero
authors: Marleen
authors: M
authors: Praet
authors: Claude
authors: C
authors: Cuvelier
authors: Eduardo
authors: E
authors: Dei-Cas
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000818:Animals; D002278:Carcinoma in Situ / Q000473:pathology; D003457:Cryptosporidiosis / Q000150:complications*; D016785:Cryptosporidium parvum / Q000472:pathogenicity*; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D007414:Intestinal Neoplasms / Q000150:complications* / Q000473:pathology; D007484:Iowa; D051379:Mice; D016513:Mice, SCID