[Objective measurement of macular optical density].
Determination of the optical density of the macular pigment may be used for an assessment of the efficacy of oral lutein supplementation in patients with dry AMD. Beside subjective methods like heterochrome flicker photometry, objective methods like the 2-wavelength auto-fluorescence method and the 1-wavelength reflection method are in clinical use today. Both methods show comparable results. For a long-term assessment of the efficacy of oral lutein supplementation, different parameters like mean and maximal optical density as well as the integral over optical density on all pixels ("volume") should be used. The parameter volume often increases also in cases in which other parameters do not change anymore. The 1-wavelength reflection method is used for the newly initiated LUTEGA study. This study will investigate the long-term effects of a fixed lutein/omega-3-fatty acid combination on the optical density in patients with dry AMD.
Dawczynski
J
J
Klinik für Augenheilkunde, Universitätsklinikum Jena, Bachstrasse 18, Jena. Jens.Dawczynski@med.uni-jena.de
Schweitzer
D
D
Lang
G E
GE
D000368:Aged; D000369:Aged, 80 and over; D003720:Densitometry / Q000379:methods*; D003941:Diagnostic Techniques, Ophthalmological; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D014975:Lutein / Q000627:therapeutic use*; D008268:Macular Degeneration / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012168:Retinal Pigments / Q000032:analysis*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
D015525:Fatty Acids, Omega-3; D012168:Retinal Pigments; D014975:Lutein