title: Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension.
abstract: Regional left ventricular (LV) systolic dysfunction has been identified in diastolic heart failure (DHF). However, the relationship between regional or global LV systolic function and heart failure symptoms in DHF has not been evaluated in detail. The present study evaluates such relationships in patients with systemic hypertension (HT) and DHF. We assessed LV systolic and diastolic function in 220 consecutive patients with systemic HT and in 30 normal individuals (Control) using Doppler echocardiography. Patients with HT were assigned to groups with DHF, asymptomatic diastolic dysfunction (ADD) and no diastolic dysfunction (Simple HT). Ejection fraction in DHF was significantly decreased (63±8%) compared with the Control, Simple HT and ADD groups (67±5, 66±7 and 68±8%, respectively). Isovolumetric contraction time in DHF (70±30 msec) was significantly increased compared with those in the ADD, Simple HT and Control groups (31±17, 31±15 and 30±19 msec, respectively). Mitral annular systolic velocities were significantly decreased in the DHF and ADD groups (6.4±1.5 and 7.2±1.3 cm sec⁻¹, respectively) compared with those in the Simple HT and Control groups (8.5±1.8 and 8.4±3.0 cm sec⁻¹, respectively), and in the DHF group compared with the ADD group. LV global systolic dysfunction has a significant role in the development of heart failure symptoms associated with DHF in patients with systemic HT.
authors: Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
authors: Mihoko
authors: M
authors: Kono
authors: Akira
authors: A
authors: Kisanuki
authors: Nami
authors: N
authors: Ueya
authors: Kayoko
authors: K
authors: Kubota
authors: Eiji
authors: E
authors: Kuwahara
authors: Kunitsugu
authors: K
authors: Takasaki
authors: Toshinori
authors: T
authors: Yuasa
authors: Naoko
authors: N
authors: Mizukami
authors: Masaaki
authors: M
authors: Miyata
authors: Chuwa
authors: C
authors: Tei
mesh_terms: D000368:Aged; D015150:Echocardiography, Doppler; D005260:Female; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging