Inhaled 1,8-cineole reduces inflammatory parameters in airways of ovalbumin-challenged Guinea pigs.
Eucalyptol, also known as 1,8-cineole, is a monoterpene traditionally used to treat respiratory disorders due to its secretolytic properties. In addition to its myorelaxant effects, it also has anti-inflammatory actions in vitro. In this study, we aimed to evaluate the efficacy of acute treatment with 1,8-cineole on reducing airway inflammatory parameters. Ovalbumin (OVA)-sensitized guinea pigs were submitted to antigenic challenge (OVA) with or without pre-treatment with a single dose of 1,8-cineole administered by inhalation. Airway inflammatory parameters were reduced or absent in 1,8-cineole-treated animals as compared with untreated guinea pigs. Acute treatment with 1,8-cineole impaired the development of airway hyperresponsiveness to carbachol in isolated tracheal rings. Levels of the pro-inflammatory cytokines TNFα and IL-1β was lower in bronchoalveolar lavage fluid (BALF) of 1,8-cineol-treated guinea pigs than in untreated animals. 1,8-Cineole impaired the OVA-induced increase of the myeloperoxidase activity in BALF. 1,8-Cineole also prevented the reduction of the mucociliary clearance induced by the antigen presentation. The present investigation provides evidence that inhaled 1,8-cineole prevents hyperresponsiveness and inhibits inflammation in airways of ovalbumin-challenged guinea pigs.
Bastos
Vasco P D
VP
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Gomes
Antoniella S
AS
Lima
Francisco J B
FJ
Brito
Teresinha S
TS
Soares
Pedro M G
PM
Pinho
João P M
JP
Silva
Claudijane S
CS
Santos
Armênio A
AA
Souza
Marcellus H L P
MH
Magalhães
Pedro J C
PJ
D000280:Administration, Inhalation; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002217:Carbachol / Q000633:toxicity; D003511:Cyclohexanols / Q000008:administration & dosage / Q000627:therapeutic use*; D016207:Cytokines / Q000378:metabolism; D000077591:Eucalyptol; D006168:Guinea Pigs; D008297:Male; D039821:Monoterpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010047:Ovalbumin / Q000633:toxicity; D014136:Tracheitis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D003511:Cyclohexanols; D016207:Cytokines; D039821:Monoterpenes; D002217:Carbachol; D010047:Ovalbumin; D000077591:Eucalyptol