[Effect of intra-operative low-dose infusion of landiolol hydrochloride on post-operative atrial fibrillation after off-pump coronary artery bypass grafting].
OBJECTIVE
The aim of this study was to evaluate the effect of intra-operative low-dose infusion of landiolol hydrochloride, a novel ultra-short acting beta-1 adrenergic receptor antagonist, on post-operative atrial fibrillation after off-pump coronary artery bypass grafting (OPCAB).


METHODS
Ninety-six patients who had undergone OPCAB were retrospectively analyzed. A landiolol group (L-group: n= 59) was compared with a control group (C-group : n= 37); the patients in the L-group were given low-dose (4.7+/- 4.3 microg/kg/min) landiolol intravenously during OPCAB. Results : Postoperative atrial fibrillation occurred in 37.8% (14/37) of C-group and 18.6% (11/59) of L-group (p = 0.037). No side effect such as profound hypotension or bradycardia was noticed during the infusion of landiolol hydrochloride.


CONCLUSIONS
Intra-operative low-dose infusion of landiolol hydrochloride decreases the incidence of postoperative atrial fibrillation after OPCAB.
Wakamatsu
Hiroki
H
Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan
Takase
Shinya
S
Sato
Yoshiyuki
Y
Seto
Yuki
Y
Kurosawa
Hiroyuki
H
Yokoyama
Hitoshi
H
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D001281:Atrial Fibrillation / Q000517:prevention & control*; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D008297:Male; D009025:Morpholines / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000319:Adrenergic beta-Antagonists; D009025:Morpholines; C077049:landiolol; D014508:Urea