Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease.
OBJECTIVE
To determine early brain changes in the distribution of an amyloid positron emission tomography (PET) probe, (11)C-labeled BF-227 or [(11)C]BF-227, in order to accurately predict the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD).


METHODS
Amyloid plaque burden was evaluated using [(11)C]BF-227 PET in AD, MCI and aged normal controls. A voxel-based analysis of [(11)C]BF-227 PET images was performed to characterize the culprit brain lesion in patients with MCI who were destined to progress to AD, referred to as MCI converters (MCI-C). In addition, binding characteristics of BF-227 to amyloid deposits were examined using postmortem AD brain samples.


RESULTS
Voxel-based statistical analyses of the BF-227 PET images clearly demonstrated an abnormal distribution of BF-227 mainly in the posterior association area in MCI-C and patients with AD. BF-227 uptake in the lateral temporal cortex was consistently observed in almost all MCI-C and patients with AD, and it distinguished MCI-C from MCI nonconverters. BF-227 binding strongly correlated with dense amyloid-β protein plaque density, but not with diffuse plaque density in the frontal cortex.


CONCLUSIONS
BF-227 uptake in the lateral temporal cortex is a reliable indicator that can be used for predicting prognosis in patients with MCI.
Shao
He
H
Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Okamura
Nobuyuki
N
Sugi
Kentaro
K
Furumoto
Shozo
S
Furukawa
Katsutoshi
K
Tashiro
Manabu
M
Iwata
Ren
R
Matsuda
Hiroshi
H
Kudo
Yukitsuka
Y
Arai
Hiroyuki
H
Fukuda
Hiroshi
H
Yanai
Kazuhiko
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D000682:Amyloid / Q000032:analysis*; D016229:Amyloid beta-Peptides / Q000032:analysis; D001583:Benzoxazoles; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000473:pathology; D003627:Data Interpretation, Statistical; D018450:Disease Progression; D004522:Educational Status; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D058225:Plaque, Amyloid / Q000473:pathology; D049268:Positron-Emission Tomography; D012737:Sex Factors; D013844:Thiazoles; D014888:Wechsler Scales
C516779:2-(2-(2-dimethylaminothiazol-5-yl)ethenyl)-6-(2-(fluoro)ethoxy)benzoxazole; D000682:Amyloid; D016229:Amyloid beta-Peptides; D001583:Benzoxazoles; D002250:Carbon Radioisotopes; D013844:Thiazoles