A dietary tomato supplement prevents prostate cancer in TRAMP mice.
Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive prostate cancer that mirrors the stages of the human form. In this study, the effects of a diet enriched with processed whole tomatoes on survival, tumorigenesis, and progression of prostate cancer, and the antioxidant and inflammatory status of TRAMP mice were investigated. Tomato diet significantly increased overall survival (P < 0.01), delayed progression from prostatic intraepithelial neoplasia to adenocarcinoma, and decreased the incidence of poorly differentiated carcinoma. Biochemical data disclosed an increase in serum antioxidant activity and a reduction of serum inflammation/angiogenesis biomarkers of particular importance in prostate carcinogenesis.
Pannellini
Tania
T
Department of Oncology and Neurosciences, G. d'Annunzio University, Chieti, Italy.
Iezzi
Manuela
M
Liberatore
Marcella
M
Sabatini
Federica
F
Iacobelli
Stefano
S
Rossi
Cosmo
C
Alberti
Saverio
S
Di Ilio
Carmine
C
Vitaglione
Paola
P
Fogliano
Vincenzo
V
Piantelli
Mauro
M
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood; D004032:Diet; D019587:Dietary Supplements; D018450:Disease Progression; D007150:Immunohistochemistry; D018551:Solanum lycopersicum; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008517:Phytotherapy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology / Q000517:prevention & control*
D000975:Antioxidants; D014408:Biomarkers, Tumor