[Expression and Clinical Significance of ABCC10 in the Patients with Non-small Cell Lung Cancer.].
BACKGROUND
Multidrug resistance (MDR) is the main reason of the failure of chemotherapy in lung cancer. The MDR mechanism in lung cancer is complex, which relates to sorts of drug resistant genes. ABCC10 is a recently identified member of a subset of the C family of ATP-binding cassette (ABC) transporters. The drug resistance capability of ABCC10 has been partly determined. The aim of the study is to investigate the expression of ABCC10 in non small cell lung cancer (NSCLC) and normal tissues, and analyze the relationship between ABCC10 expression level and clinical features, such as TNM stages, histological types and pathological grades.


METHODS
The expression of ABCC10 was detected in squamous cell carcinoma, adenocarcinoma and normal lung tissues by immunohistochemistry. Then the statistical analysis was performed.


RESULTS
The expression of ABCC10 was mainly located in cell membrane and cytoplasm. There were significant differences between the expression of ABCC10 in NSCLC and normal tissues (P<0.01). The positive rates in squamous cell carcinoma and adenocarcinoma were 73.26% and 81.16%, respectively with significant differences (P<0.05). There were significant differences among histological grades in squamous cell carcinoma (P<0.01). There were significant differences among histological grades and TNM stages respectively in adenocarcinoma (P<0.01).


CONCLUSIONS
ABCC10 is overexpressed in NSCLC. The expression of ABCC10 in adenocarcinoma is higher than that in squamous cell carcinoma. The expression in adenocarcinoma is correlated to pathological grades and TNM stages. The results of this study would be benefit for further study of ABCC10 in tumor and its chemoresistance.
Wang
Peng
P
Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.
Zhang
Zhipei
Z
Gao
Kunxiang
K
Deng
Yingchun
Y
Zhao
Jinbo
J
Liu
Boya
B
Li
Xiaofei
X