title: Evaluation of iodine, iron, and selenium in biological samples of thyroid mother and their newly born babies.
abstract: BACKGROUND
  There is accumulating facts that the metabolism of essential trace elements is altered in thyroid patients.
  
  
  OBJECTIVE
  The aim of present study was to compare the status of essential trace elements, iodine, iron (Fe), and selenium (Se) in biological samples (serum and urine) of goitrous mothers (age ranged 30-40) and their newly born infants (n=76). An age matched 68 non-goitrous mothers and their infants, residing in the same locality, were selected as referents. For a comparative study, the biological samples of non-goitrous and goitrous pregnant and non pregnant female subjects of the same age group and socio-economic status were also analyzed.
  
  
  METHODS
  The Fe and Se concentrations in biological samples were determined by a flame and hydride generation atomic absorption spectrometry respectively, while iodine was measured by iodide-ion selective electrode, prior to microwave assisted acid digestion. The validity and accuracy of the methodology was checked by certified reference materials.
  
  
  RESULTS
  The mean values of iodine, Fe and Se in serum and urine samples of thyroid mothers and their infants were significantly lower as compared to the referent mothers-infants pairs (p<0.01).
  
  
  CONCLUSIONS
  The deficiencies of essential trace elements may adversely affect the health of women and their neonates.
authors: National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. tgkazi@yahoo.com
authors: Tasneem Gul
authors: TG
authors: Kazi
authors: Ghulam Abbas
authors: GA
authors: Kandhro
authors: Sirajuddin
authors: Hassan Imran
authors: HI
authors: Afridi
authors: Jameel Ahmed
authors: JA
authors: Baig
authors: Abdul Qadir
authors: AQ
authors: Shah
authors: Sham Kumar
authors: SK
authors: Wadhwa
authors: Sumaira
authors: S
authors: Khan
authors: Nida Fatima
authors: NF
authors: Kolachi
authors: Hafeez-ur-Rahman
authors: HU
authors: Shaikh
mesh_terms: D000328:Adult; D001724:Birth Weight; D001774:Blood Chemical Analysis; D005260:Female; D006043:Goiter, Endemic / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007455:Iodine / Q000032:analysis / Q000378:metabolism*; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D012643:Selenium / Q000032:analysis / Q000378:metabolism*; D016482:Urinalysis
chemical_list: D007455:Iodine; D007501:Iron; D012643:Selenium