title: Favorable clinical outcome using a covered stent following transjugular intrahepatic portosystemic shunt in patients with portal hypertension.
abstract: OBJECTIVE
  To compare retrospectively the clinical outcomes in patients treated with transjugular intrahepatic portosystemic shunt (TIPS) using the novel polytetrafluoroethylene-covered stents (Fluency) and bare stents.
  
  
  METHODS
  Sixty consecutive patients with portal hypertension treated with TIPS from April 2007 to April 2009 were included. TIPS creation was performed with Fluency stent grafts in 30 patients (group A) and with bare stents in 30 patients (group B). Liver function, TIPS patency and clinical outcomes were evaluated every 3 months after procedures.
  
  
  RESULTS
  During hospitalization, there were no cases of hepatic encephalopathy (HE) and recurrence of variceal bleedings. Acute shunt occlusion was found in one patient in each group. Follow-ups were performed in group A with average time of 6.16 +/- 3.89 months and in group B with 8.34 +/- 4.42 months. The rates of recurrent bleeding, shunt occlusion, HE and mortality were 0.03, 0.0, 16.7 and 0% in group A, and 20.0, 30.0, 20.0 and 13.3% in group B, respectively. There was no difference of HE between group A and group B. The decrease of portal pressure and portosystemic pressure gradient, and the increase of portal flow were 34.1 and 23.3%, 60.0 and 52.8%, and 189.5 and 111.1% in group A and B, respectively. There were no differences of liver function between group A and B.
  
  
  CONCLUSIONS
  The Fluency stent graft is relatively safe and effective in TIPS creation, with a high patency rate compared with bare stents.
authors: Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China. wxj_wxj@sohu.com
authors: Xingjiang
authors: X
authors: Wu
authors: Weiwei
authors: W
authors: Ding
authors: Jianmin
authors: J
authors: Cao
authors: Jianmin
authors: J
authors: Han
authors: Qian
authors: Q
authors: Huang
authors: Ning
authors: N
authors: Li
authors: Jieshou
authors: J
authors: Li
mesh_terms: D001783:Blood Flow Velocity; D020099:Coated Materials, Biocompatible; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D017082:Portal Pressure / Q000502:physiology*; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods*; D011474:Prosthesis Design; D012189:Retrospective Studies; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color
chemical_list: D020099:Coated Materials, Biocompatible; D011138:Polytetrafluoroethylene