title: Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models.
abstract: beta-thalassemia is a disease associated with decreased beta-globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically-relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.
authors: Division of Hematology-Oncology, Department of Pediatrics, Children's Blood Foundation Laboratories, Weill Medical College of Cornell University, New York, New York, USA.
authors: Pedro
authors: P
authors: Ramos
authors: Luca
authors: L
authors: Melchiori
authors: Sara
authors: S
authors: Gardenghi
authors: Nico
authors: N
authors: Van-Roijen
authors: Robert W
authors: RW
authors: Grady
authors: Yelena
authors: Y
authors: Ginzburg
authors: Stefano
authors: S
authors: Rivella
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000502:physiology*; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000378:metabolism; D051379:Mice; D017086:beta-Thalassemia / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D064451:Hepcidins; D007501:Iron