[Hepatitis B vaccination effectiveness based on anti-HBs antibodies presence in children vertically infected with HIV].
OBJECTIVE
To evaluate hepatitis B vaccination effectiveness.


METHODS
49 vertically HIV-infected children were enrolled. Anti-HBs antibodies were evaluated at HIV diagnosis, at evaluation (year 2004) and after primary vaccination. The following factors were analyzed: age, time since the last vaccine dose, clinical and immunological CDC category, HIV viral load, age at the beginning of ART.


RESULTS
At HIV diagnosis 14% of children had anti-HBs antibody level > or = 100 mLU/ml. At evaluation 76% of patients had anti-HBs antibody level > or = 100 mIU/ml. Children, who were diagnosed before their first birthday, were more likely to have protective antibody level (p < 0.01). Percentage of lymphocyte T CD4+ count (p < 0.01) and time since last vaccination (p < 0.01) were found to be important factors of vaccination response. Primary vaccination was effective in 86% of children.


CONCLUSIONS
Factors which influenced vaccination effectiveness included early HIV diagnosis, percentage of lymphocyte T CD4+ at evaluation and time since last vaccination. The effectiveness of primary vaccination was high.
Ołdakowska
Agnieszka
A
Klinika Chorób Zakaźnych Wieku Dzieciecego, Warszawski Uniwersytet Medyczny, Wojewódzki Szpital Zakaźny w Warszawie.
Marczyńska
Magdalena
M
D000293:Adolescent; D018791:CD4 Lymphocyte Count; D002648:Child; D002662:Child Health Services / Q000458:organization & administration; D002669:Child Welfare; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission*; D020276:HIV Long-Term Survivors / Q000706:statistics & numerical data; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis* / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008297:Male
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines