title: Antinociceptive activity of steroid alkaloids isolated from Solanum trilobatum Linn.
abstract: Solasodine (1) was isolated for the first time from the roots of Solanum trilobatum Linn., a member of the Solanaceae, and assessed for its presumed antinociceptive activity using several experimental murine models, viz. the writhing, formalin, and hot plate tests. When used at doses of 2, 4, and 8 mg/kg, this steroidal alkaloid caused a significant and dose-dependent decrease in the nociception induced by an intraperitoneal injection of acetic acid (p < 0.001). It also led to a significant reduction of the painful sensation caused by formalin in both phases of the formalin test (p < 0.001). Furthermore, the alkaloid produced a significant increase in the reaction time in the hot plate test (p < 0.001). These results suggest that solasodine elicited antinociceptive activity through both central and peripheral mechanisms.
authors: School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India. pandu115@gmail.com
authors: Annamalai
authors: A
authors: Pandurangan
authors: Ratan Lal
authors: RL
authors: Khosa
authors: Siva
authors: S
authors: Hemalatha
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement; D010423:Pentazocine / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012991:Solanaceous Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000700:Analgesics; D012991:Solanaceous Alkaloids; D013256:Steroids; C012037:solasodine; D019342:Acetic Acid; D010423:Pentazocine