Interferon regulatory factor 4: combinational control of lymphocyte differentiation.
Transcriptional mechanisms involved in the differentiation of the recently identified interleukin-9 (IL-9) secreting T helper cell subset are still poorly defined. In this issue of Immunity, Staudt et al. (2010) now report an essential role for the interferon regulatory factor-4 in IL-9 production.
Veldhoen
Marc
M
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. marc.veldhoen@bbsrc.ac.uk