title: Coronary artery disease: which degree of coronary artery stenosis is indicative of ischemia?
abstract: OBJECTIVE
  To prospectively determine the best cut-off value of stenosis degree for low-dose computed tomography coronary angiography (CTCA) to predict the hemodynamic significance of coronary artery stenoses compared to catheter angiography (CA) using a cardiac magnetic resonance based approach as standard of reference.
  
  
  METHODS
  Fifty-two patients (mean age, 64±10 years) scheduled for CA underwent cardiac magnetic resonance (CMR) at 1.5-T and dual-source CTCA using prospective ECG-triggering the same day. Diagnostic performance of CTCA and CA to detect myocardial ischemia was evaluated with CMR as the standard of reference. The diagnostic performance and best cut-off values to predict the hemodynamic significance of coronary were determined from receiver operating characteristics analysis (ROC).
  
  
  RESULTS
  CA revealed >50% stenoses in 131/832 segments (15.7%) in 78/156 (50.0%) coronary arteries in 32/52 (62%) patients. CTCA revealed >50% stenoses in 148/807 (18.3%) segments, corresponding to 83/156 (53.2%) coronary arteries in 34/52 (65.4%) patients. CMR revealed ischemia in 118/832 (14.2%) myocardial segments corresponding to the territories of 60/156 (38.5%) coronary arteries in 29/52 (56%) patients. ROC analysis showed equal diagnostic performance for low-dose CTCA and CA with areas under the curve (AUC) of 0.82 and 0.83 (P=0.64). The optimal cut-off value was determined at stenosis of >60% for the prediction of hemodynamically significant coronary stenosis by CTCA. Using this cut-off value, sensitivity, specificity, NPV and PPV to predict hemodynamic significance by CTCA were 100%, 83%, 100%, and 88% on a per-patient basis and 88%, 73%, 83% and 81% on a per-artery analysis, respectively.
  
  
  CONCLUSIONS
  By considering coronary stenosis >60%, diagnostic performance for predicting the hemodynamic significance of coronary stenosis by CTCA is optimal and equals that of CA.
authors: Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland.
authors: Olivio F
authors: OF
authors: Donati
authors: Paul
authors: P
authors: Stolzmann
authors: Lotus
authors: L
authors: Desbiolles
authors: Sebastian
authors: S
authors: Leschka
authors: Sebastian
authors: S
authors: Kozerke
authors: André
authors: A
authors: Plass
authors: Christophe
authors: C
authors: Wyss
authors: Volkmar
authors: V
authors: Falk
authors: Borut
authors: B
authors: Marincek
authors: Hatem
authors: H
authors: Alkadhi
authors: Hans
authors: H
authors: Scheffel
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D011829:Radiation Dosage; D014057:Tomography, X-Ray Computed