Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients.
In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.
Faria-Pinto
Priscila de
Pd
Departamento de Bioquímica, Instituto de Ciências Biológicas, Laboratório de Estrutura e Função de Proteínas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.
Mendes
Rita Gabriela Pedrosa Ribeiro
RG
Carvalho-Campos
Cristiane de
Cd
Maia
Ana Carolina Ribeiro Gomes
AC
Oliveira
Aureo Almeida
AA
Coelho
Paulo Marcos Zech
PM
Vasconcelos
Eveline Gomes
EG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000276:immunology*; D001081:Apyrase / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000276:immunology*; D011198:Solanum tuberosum / Q000201:enzymology*; D055815:Young Adult
D000871:Anthelmintics; D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D011223:Praziquantel; D001081:Apyrase