title: Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability.
abstract: Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. When such a system is released in the lumen of the gastrointestinal tract, it disperses to form a fine emulsion (micro/nano) with the aid of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. This article presents an exhaustive account of various literature reports on diverse types of self-emulsifying formulations with emphasis on their formulation, characterization and in vitro analysis, with examples of currently marketed preparations.
authors: Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 62, India.
authors: Kanchan
authors: K
authors: Kohli
authors: Sunny
authors: S
authors: Chopra
authors: Deepika
authors: D
authors: Dhar
authors: Saurabh
authors: S
authors: Arora
authors: Roop K
authors: RK
authors: Khar
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D045703:Emulsifying Agents; D004655:Emulsions / Q000032:analysis / Q000737:chemistry; D005079:Excipients; D006801:Humans; D008055:Lipids; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D045703:Emulsifying Agents; D004655:Emulsions; D005079:Excipients; D008055:Lipids; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents