Anti-hypoxia activity and related components of Rhodobryum giganteum par.
Different extracts of Rhodobryum giganteum Par. were screened with mice model of acute myocardial hypoxia induced by isoproterenol and pituitrin, eight compounds, i.e. p-hydroxycinnamic acid, caffeic acid-4-O-β-d-glucopyranoside, salicin, 7,8-dihydroxy coumarin, menthol, allantoin, palmitic acid, palmitamide were isolated and identified from the active fraction, among which p-hydroxycinnamic acid and 7,8-dihydroxy coumarin were confirmed having protective effects on myocardial hypoxia-reoxygenation injury, suggesting that these two components were major active ingredients of R. giganteum for cardiovascular disease.
Cai
Ying
Y
General Hospital of Nanjing Military Area Command of Chinese PLA, Nanjing 210002, China.
Lu
Yu
Y
Chen
Ruihua
R
Wei
Qunli
Q
Lu
Xiaohe
X
D000818:Animals; D044002:Bryophyta / Q000737:chemistry*; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy*; D007545:Isoproterenol; D008297:Male; D051379:Mice; D015428:Myocardial Reperfusion Injury / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010909:Pituitary Hormones, Posterior; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002934:Cinnamates; D003374:Coumarins; D010909:Pituitary Hormones, Posterior; D010936:Plant Extracts; C029010:cinnamic acid; C030123:coumarin; D007545:Isoproterenol