Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.
Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n=4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) =0.0067; odds ratio=1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.
Desrivières
Sylvane
S
MRC-SGDP Centre, Institute of Psychiatry, Kings College, UK.
Lourdusamy
Anbarasu
A
Müller
Christian
C
Ducci
Francesca
F
Wong
Cybele P
CP
Kaakinen
Marika
M
Pouta
Anneli
A
Hartikainen
Anna-Liisa
AL
Isohanni
Matti
M
Charoen
Pimphen
P
Peltonen
Leena
L
Freimer
Nelson
N
Elliott
Paul
P
Jarvelin
Marjo-Riitta
MR
Schumann
Gunter
G
D000293:Adolescent; D017668:Age of Onset; D000428:Alcohol Drinking / Q000235:genetics; D000435:Alcoholic Intoxication / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012737:Sex Factors
C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid