Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae).
A new bioactive sterol glycoside, 3beta-O-(3',4'-di-O-acetyl-beta-D-arabinopyranosyl)-25xi-cholestane-3beta,5alpha,6beta,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
Liu
Chih-Yang
CY
Department of Life Science and Graduate Institute of Biotechnology, Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan. belle_ames@hotmail.com
Hwang
Tsong-Long
TL
Lin
Mei-Ru
MR
Chen
Yung-Husan
YH
Chang
Yu-Chia
YC
Fang
Lee-Shing
LS
Wang
Wei-Hsien
WH
Wu
Yang-Chang
YC
Sung
Ping-Jyun
PJ
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
C553816:3-O-(3',4'-di-O-acetylarabinopyranosyl)cholestane-3,5,6,26-tetrol-26-acetate; D000970:Antineoplastic Agents; D006027:Glycosides; D012503:Saponins; D013261:Sterols; D013481:Superoxides; D010196:Pancreatic Elastase