title: Two step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines.
abstract: A two-step solution phase synthesis employing a double UDC (Ugi/Deprotect/Cyclize) strategy has been utilized to obtain fused 6,7,6,6-quinoxalinone-benzodiazepines and 6,7,7,6-bis-benzodiazepines. Optimization of the methodology to produce these tetracyclic scaffolds was enabled by microwave irradiation, incorporation of trifluoroethanol as solvent, and the use of the convertible isocyanide, 4-tert-butyl cyclohexen-1-yl isocyanide.
authors: College of Pharmacy, Department of Pharmacology and Toxicology, Division of Medicinal Chemistry, BIO5 Institute, Southwest Comprehensive Center for Drug Discovery and Development, University of Arizona, AZ 85721.
authors: Zhigang
authors: Z
authors: Xu
authors: Justin
authors: J
authors: Dietrich
authors: Arthur Y
authors: AY
authors: Shaw
authors: Christopher
authors: C
authors: Hulme