title: Fronto-limbic abnormalities in a patient with compulsive hoarding: a 99mTc-ECD SPECT study.
abstract: Little is known about the neuronal mechanism underpinning the pathophysiology of compulsive hoarding. We report the cerebral blood flow changes in an obsessive-convulsive patient with severe hoarding. The patient showed hyperperfusion of the fronto-temporal region and hypoperfusion of the striatal, the middle cingulate and the medial temporal regions during the stage with severe symptoms. Following improvement from the hoarding behaviors, the extent of hypoperfusion was expanded in the bilateral striatum, the anterior and middle cingulate gyrus. The result may substantiate evidence of the fronto-limbic abnormality involved in the pathophysiology of compulsive hoarding.
authors: Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
authors: Hiromasa
authors: H
authors: Ohtsuchi
authors: Koji
authors: K
authors: Matsuo
authors: Takashi
authors: T
authors: Akimoto
authors: Yoshifumi
authors: Y
authors: Watanabe
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D002560:Cerebrovascular Circulation; D003192:Compulsive Behavior / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D003545:Cysteine / Q000031:analogs & derivatives; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008032:Limbic System / Q000098:blood supply / Q000000981:diagnostic imaging*; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D000077152:Olanzapine; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D020127:Recovery of Function; D018967:Risperidone / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D001569:Benzodiazepines; C059659:technetium Tc 99m bicisate; D003545:Cysteine; D018967:Risperidone; D000077152:Olanzapine