RGD-cyclam conjugate: synthesis and potential application for positron emission tomography.
Cyclam and DOTA-containing positron emission tomography radiotracers were prepared by using a modular chemical strategy based on peptide synthesis and chemoselective ligations. These molecules encompass two functional domains, one a tumour 'homing' domain and the other a chelating ligand for copper allowing nuclear imaging of tumours.
Galibert
Mathieu
M
Département de Chimie Moléculaire, UMR-5250, CNRS-Université Joseph Fourier, Grenoble, France.
Jin
Zhao-Hui
ZH
Furukawa
Takako
T
Fukumura
Toshimitsu
T
Saga
Tsuneo
T
Fujibayashi
Yasuhisa
Y
Dumy
Pascal
P
Boturyn
Didier
D
D000818:Animals; D003301:Copper Radioisotopes / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D009842:Oligopeptides / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
D003301:Copper Radioisotopes; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D009842:Oligopeptides; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; C024560:cyclam; C047981:arginyl-glycyl-aspartic acid