[Expression of B7-H4 in prostate cancer and its clinical significance].
To investigate the expression of B7-H4 in prostate cancer tissue and the relationship between the expression and the clinicopathological features.



Immunohistochemical staining was used to detect the expression of B7-H4 in prostate cancer tissue. And the relationship between the expressions and pathology was evaluated.



The B7-H4 was diffusely expressed in cytoplasm and/or membrane of the prostate cancer tissue; the expression was much higher than that in normal prostate tissue (P<0.05). The expression of B7-H4 in the prostate cancer tissue was higher in patients with higher tumor grade.



B7-H4 may be used as an new indicator for the diagnosis and prognosis of prostate cancer and a novel target for immunotherapy.
Qian
Yun
Y
Institute of Immunology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Yao
Hang-ping
HP
Shen
Ling
L
Cheng
Lin-fang
LF
Zhang
Li-huang
LH
D000368:Aged; D000369:Aged, 80 and over; D018122:B7-1 Antigen / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1
D018122:B7-1 Antigen; D014408:Biomarkers, Tumor; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; C475826:VTCN1 protein, human