title: Lower trabecular volumetric BMD at metaphyseal regions of weight-bearing bones is associated with prior fracture in young girls.
abstract: Understanding the etiology of skeletal fragility during growth is critical for the development of treatments and prevention strategies aimed at reducing the burden of childhood fractures. Thus we evaluated the relationship between prior fracture and bone parameters in young girls. Data from 465 girls aged 8 to 13 years from the Jump-In: Building Better Bones study were analyzed. Bone parameters were assessed at metaphyseal and diaphyseal sites of the nondominant femur and tibia using peripheral quantitative computed tomography (pQCT). Dual-energy X-ray absorptiometry (DXA) was used to assess femur, tibia, lumbar spine, and total body less head bone mineral content. Binary logistic regression was used to evaluate the relationship between prior fracture and bone parameters, controlling for maturity, body mass, leg length, ethnicity, and physical activity. Associations between prior fracture and all DXA and pQCT bone parameters at diaphyseal sites were nonsignificant. In contrast, lower trabecular volumetric BMD (vBMD) at distal metaphyseal sites of the femur and tibia was significantly associated with prior fracture. After adjustment for covariates, every SD decrease in trabecular vBMD at metaphyseal sites of the distal femur and tibia was associated with 1.4 (1.1-1.9) and 1.3 (1.0-1.7) times higher fracture prevalence, respectively. Prior fracture was not associated with metaphyseal bone size (ie, periosteal circumference). In conclusion, fractures in girls are associated with lower trabecular vBMD, but not bone size, at metaphyseal sites of the femur and tibia. Lower trabecular vBMD at metaphyseal sites of long bones may be an early marker of skeletal fragility in girls.
authors: Department of Physiological Sciences, University of Arizona, Tucson, AZ 85721-0093, USA. jfarr@email.arizona.edu
authors: Joshua N
authors: JN
authors: Farr
authors: Rita
authors: R
authors: Tomás
authors: Zhao
authors: Z
authors: Chen
authors: Jeffrey R
authors: JR
authors: Lisse
authors: Timothy G
authors: TG
authors: Lohman
authors: Scott B
authors: SB
authors: Going
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000886:Anthropometry / Q000379:methods; D001823:Body Composition; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D005260:Female; D050723:Fractures, Bone / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D015233:Models, Statistical; D009043:Motor Activity; D009142:Musculoskeletal Physiological Phenomena; D014057:Tomography, X-Ray Computed / Q000379:methods