title: Tuning mTORC1 activity for balanced self-renewal and differentiation.
abstract: Understanding the mechanisms that control stem cell self-renewal and differentiation are at the core of stem cell biology. In a recent issue of Cell, Hobbs et al. report that harnessing mTORC1 activity by the transcription factor PLZF is crucial to maintain the self-renewing activity of germline progenitors.
authors: Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
authors: Larissa S
authors: LS
authors: Carnevalli
authors: Andreas
authors: A
authors: Trumpp