Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure.
OBJECTIVE
Dietary quality probably may impact heart failure outcomes. The aim of the study was to determine the potential effects of nutrient intake on homocysteine, MCP-1 and GGT levels in patients with heart failure.


METHODS
The study group comprised 55 patients with diagnosed HF with coronary artery disease origin, below 65y, with NYHA class I/II. The patients had received standard treatment. The control comprised 55 patients with mild hyperlipidemia, not treated. Diet was evaluated on the basis of a dietary questionnaire and a 24-h dietary recall. The serum lipid profile, folic acid, homocysteine, GGT and MCP-1 were determined.


RESULTS
In the HF group significantly higher concentration of homocysteine (32%), MCP-1 (58%) and GGT (100%) are found as compared to the control group (p < 0.00001). Patients with HF had greater cholesterol consumption, with less folates, vitamin C and dietary fiber as compared to the control group (p < 0.05).


CONCLUSIONS
High consumption of total fat and dietary cholesterol accompanied by a low folate, antioxidant vitamin, a special vitamin C and dietary fiber intake, contributes to elevated Hcy, GGT and MCP-1 levels and in consequence, could lead to intense inflammatory process and atherosclerosis in HF patients.
Makarewicz-Wujec
Magdalena
M
Department of Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Poland. magdalena.wujec@wum.edu.pl
Kozlowska-Wojciechowska
Malgorzata
M
D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D002791:Cholesterol, Dietary / Q000097:blood; D002149:Energy Intake; D005260:Female; D005492:Folic Acid / Q000097:blood; D006333:Heart Failure / Q000097:blood; D006397:Hematinics / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011795:Surveys and Questionnaires; D005723:gamma-Glutamyltransferase / Q000097:blood*
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D002791:Cholesterol, Dietary; D006397:Hematinics; D006710:Homocysteine; D005492:Folic Acid; D005723:gamma-Glutamyltransferase