Brønsted acid catalyzed asymmetric aldol reaction: a complementary approach to enamine catalysis.
A syn-enantioselective aldol reaction has been developed using Brønsted acid catalysis based on H(8)-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various beta-hydroxy ketones, some of which could not be synthesized using enamine organocatalysis.
Pousse
Guillaume
G
Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, France.
Le Cavelier
Fabien
F
Humphreys
Luke
L
Rouden
Jacques
J
Blanchet
Jérôme
J
D000546:Amanitins / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry; D013237:Stereoisomerism
D000546:Amanitins; D007659:Ketones; D010756:Phosphoric Acids; C049964:aldoamanitin