Interleukin 10 gene polymorphism in Iranian patients with multiple sclerosis.
OBJECTIVE
IL-10 suppresses several activities of the immune response by inhibition of Th1 and Th2 cells.


METHODS
We studied 110 Iranian patients with clinically definite multiple sclerosis (MS) and 100 ethnic and age matched controls. Three single-nucleotide polymorphisms in the proximal region of IL-10 promoter gene (-1082/-819/-592) were analysed by amplification refractory mutation system (ARMS) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.


RESULTS
The -1082 (G/A), -819 (T/C) and -592 (A/C) genotypes were similarly distributed between MS patients and the controls. There was no statistically significant difference in the allelic and genotype distribution between patients and controls. In addition, gender, course and progression index did not reveal any statistically significant differences in the allele and genotype distribution of IL-10 polymorphisms.


CONCLUSIONS
As a non-European patient population, according to our results, IL10 polymorphism is not associated with MS and its subtypes nor influences the disease progression.
Azarpira
Negar
N
Transplantation Research Center, Shiraz University of Medical Sciences, Iran.
Borhani Haghighi
Afshin
A
Pourjafar
Mehrzad
M
Shariat
Abdolhamid
A
D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007492:Iran; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D016753:Interleukin-10