[Preclinical safety investigation of GB-115 dipeptide].
Preclinical safety investigations of newly synthesized dipeptide compound GB-115 (amide N-phenylhexanoyl-glycyl-L-tryptophan), an antagonist of cholecystokinin receptors, were performed. No animals were lost after GB-115 acute oral administration at a maximum dose of 6000 mg/kg in mice and at 3500 mg/kg in rats. GB-115 administered per os during 6 months in rabbits and rats (both males and females) at the doses of 0.1 and 10 mg/kg induced no irreversible pathological changes in organs and systems studied. The tested dipeptide exhibited no allergenic, immunotoxic and mutagenic activity, and did not affect generative function and the antenatal and postnatal development of progeny. GB-115 at a dose of 10 mg/kg produced suppression of the inflammatory reaction to concanavalin A.
Sorokina
A V
AV
Alekseeva
S V
SV
Nemova
E P
EP
Kovalenko
L P
LP
Smol'nikova
N M
NM
Shipaeva
E V
EV
Shreder
O V
OV
Miroshkina
I A
IA
Diukova
S A
SA
Daugel'-Dauge
N O
NO
Kulakova
A V
AV
Kolik
L G
LG
Durnev
A D
AD
Seredenin
S B
SB
D000818:Animals; D003208:Concanavalin A / Q000009:adverse effects / Q000494:pharmacology; D004151:Dipeptides / Q000009:adverse effects* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*
D004151:Dipeptides; C520797:GB-115; D011949:Receptors, Cholecystokinin; D003208:Concanavalin A