title: Antifungal activity of the osthol derivative JS-B against Phytophthora capsici.
abstract: JS-B (C(12)H(10)O(3)) is a derivative compound of osthol. The antifungal properties of JS-B were tested against 10 economically important plant pathogens. JS-B was effective in inhibiting the mycelial growth of Phytophthora capsici, and its inhibition on different stages of the life cycle of P. capsici was observed. The 50% effective concentration (EC(50)) of JS-B on mycelial dry weight and zoospore germination of P. capsici was 43.74 and 86.03 microg/ml, respectively. The rupture of released zoospores induced by JS-B was reduced by the addition of 100 mM glucose. The ultrastructural study showed that JS-B caused destruction of most of the mitochondrions, the concentration of cell nuclear, and the existing vesicles. When compared with dimethomorph, the activity of JS-B on P. capsici was determined under pot conditions. The result showed that JS-B has a curative effect on pepper blight.
authors: Food Safety Research and Service Institute, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
authors: Chun-Mei
authors: CM
authors: Wang
authors: Wei
authors: W
authors: Guan
authors: Shu
authors: S
authors: Fang
authors: Hao
authors: H
authors: Chen
authors: You-Qin
authors: YQ
authors: Li
authors: Chun
authors: C
authors: Cai
authors: Yong-Jian
authors: YJ
authors: Fan
authors: Zhi-Qi
authors: ZQ
authors: Shi
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010838:Phytophthora / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D003374:Coumarins; C551907:JS-B compound; C046627:osthol