title: In vitro activity of tigecycline and comparators on Acinetobacter spp. isolates collected from patients with bacteremia and MIC change during the Tigecycline Evaluation and Surveillance Trial, 2004 to 2008.
abstract: The Tigecycline Evaluation and Surveillance Trial is a global surveillance study established in 2004 to monitor the activity of tigecycline, a new glycylcycline, and several comparators against an array of important Gram-positive and Gram-negative pathogens. In this study, we examined 1591 isolates of Acinetobacter from blood samples collected from 352 centers globally between 2004 and 2008. Tigecycline showed an MIC(90) (1 microg/mL) globally, with a maximum regional value of 4 microg/mL (Middle East) reported. Antimicrobial susceptibility was notably higher among nonintensive care unit (non-ICU) isolates than isolates collected from ICUs. Carbapenem-resistant Acinetobacter were more prevalent in the Middle East, Latin America, and Asia/Pacific rim than in Europe or North America. Tigecycline creep was noted between 2004 and 2007, corresponding closely to changes in MIC(90).
authors: Grady Memorial Hospital, Atlanta, GA 30303, USA. yfwang@emory.edu
authors: Yun F Wayne
authors: YF
authors: Wang
authors: Michael J
authors: MJ
authors: Dowzicky
mesh_terms: D000150:Acinetobacter / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia / Q000453:epidemiology; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology*; D001769:Blood / Q000382:microbiology; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007362:Intensive Care Units; D007843:Latin America / Q000453:epidemiology; D008826:Microbial Sensitivity Tests / Q000592:standards; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D009656:North America / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods*; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D000078304:Tigecycline; D008911:Minocycline