Two new chamigrane metabolites from fermentation broth of Steccherinum ochraceum.
Two new chamigrane-type metabolites named steperoxides C (1) and D (2) were isolated from the basidiomycetes Steccherinum ochraceum. The structures of 1 and 2 were established on the basis of spectral methods (MS, IR, ID and 2D NMR experiments). Compounds 2 showed significant antimicrobial activity against Staphylococcus aureus at 10 and 5 μg/disk.
Liu
Dong-Ze
DZ
Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. dongzeliu@scsio.ac.cn
Luo
Ming-He
MH
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring; C556942:steperoxide C; C556943:steperoxide D