title: Influence of chirality using Mn(III) salen complexes on DNA binding and antioxidant activity.
abstract: Chiral Mn(iii) salen complexes S-1, R-1, S-2, R-2, S-3 and R-3 derived from the respective chiral salen ligands, viz., (1S,2S)-N,N'-bis-[3-tert-butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine S-1'/(1R,2R)-N,N'-bis-[3-tert-butyl-5-chloromethyl-salicylidine]-1,2-cyclohexanediamine R-1'/(1S,2S)-N,N'-bis-[3-tert-butyl-5-N,N'N'triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride S-2'/(1R,2R)-N,N'-bis-[3-tert-butyl-5-N,N'N'triethylaminomethyl-salicylidine]-1,2-cyclohexanediamine dichloride R-2'/(1S,2S)-N,N'-bis-[3,5-di-tert-butylsalicylidene]-1,2-cyclohexanediamine S-3' and (1R,2R)-N,N'-bis-[3,5-di-tert-butyl-salicylidene]-1,2-cyclohexanediamine R-3', were synthesized. Characterization of the complexes was done by microanalysis, IR, LC-MS, UV-vis. and circular dichroism (CD) spectroscopy. Binding of these complexes with calf thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, circular dichroism measurements, thermal denaturation study and observation of their different antioxidant activities. Among all the complexes used, the best result in terms of binding constant (intercalative) (130.4 x 10(4)) was achieved with the complex S-1 by spectroscopic titration. The complex S-1 showed strong antioxidant activity as well.
authors: Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific & Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021, Gujarat, India. khan251293@yahoo.in
authors: Noor-Ul H
authors: NU
authors: Khan
authors: Nirali
authors: N
authors: Pandya
authors: Manoj
authors: M
authors: Kumar
authors: Prasanta Kumar
authors: PK
authors: Bera
authors: Rukhsana I
authors: RI
authors: Kureshy
authors: Sayed H R
authors: SH
authors: Abdi
authors: Hari C
authors: HC
authors: Bajaj
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D008024:Ligands; D017895:Manganese Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D013237:Stereoisomerism; D013481:Superoxides / Q000378:metabolism; D014783:Viscosity / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D008024:Ligands; D017895:Manganese Compounds; D010851:Picrates; D013481:Superoxides; D004247:DNA; C427203:calf thymus DNA; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl