title: Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.
abstract: Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.
authors: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan.
authors: Soichiro
authors: S
authors: Ide
authors: Shunsuke
authors: S
authors: Fujiwara
authors: Masayuki
authors: M
authors: Fujiwara
authors: Ichiro
authors: I
authors: Sora
authors: Kazutaka
authors: K
authors: Ikeda
authors: Masabumi
authors: M
authors: Minami
authors: George R
authors: GR
authors: Uhl
authors: Kumatoshi
authors: K
authors: Ishihara
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D003511:Cyclohexanols / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017450:Receptors, Opioid, mu / Q000172:deficiency* / Q000235:genetics; D013550:Swimming / Q000502:physiology; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D017450:Receptors, Opioid, mu; D000069470:Venlafaxine Hydrochloride