Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates.
We report on a low-level detection of anti-cancer drug (paclitaxel) in blood plasma using microwave-treated gold (Au) film-polystyrene (PS) beads as surface-enhanced Raman scattering (SERS) substrates. SERS spectra of paclitaxel can be acquired within 10s at a concentration of 1×10(-8) M in blood plasma adsorbed on the modified Au-PS SERS substrates. The concentrations of paclitaxel ranging from 1.0×10(-8) to 1.0×10(-7) M in blood plasma can be well estimated with an accuracy of ∼3.8×10(-9) M using SERS technique. This work shows the promise of applying microwave-modified Au-PS as SERS substrates for rapid and accurate monitoring of the anti-cancer drug in blood plasma for immediate treatment decisions during cancer therapy.
Yuen
Clement
C
Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9, Engineering Drive 1, Singapore 117576, Singapore.
Zheng
Wei
W
Huang
Zhiwei
Z
D000970:Antineoplastic Agents / Q000097:blood; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000737:chemistry* / Q000528:radiation effects; D006801:Humans; D008832:Microchemistry / Q000295:instrumentation*; D008863:Microspheres; D008872:Microwaves; D017239:Paclitaxel / Q000097:blood*; D011137:Polystyrenes / Q000737:chemistry* / Q000528:radiation effects; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*
D000970:Antineoplastic Agents; D011137:Polystyrenes; D006046:Gold; D017239:Paclitaxel