Long-term physical and neurologic development in newborn infants with isolated single umbilical artery.
OBJECTIVE
This study compared birth parameters and the longitudinal course in physical and neurologic development between children with 2 and 3 vessel umbilical cords.


METHODS
Our study of the Collaborative Perinatal Project included singletons of at least 24 weeks' gestation with single umbilical artery at birth and no identifiable congenital anomalies. Demographics that were collected included maternal age, race, smoking status, and socioeconomic index. Delivery data included gestational age, birthweight, Apgar scores, placental weight, and umbilical cord insertion and length. Growth and neurodevelopmental parameters were collected at various intervals from birth to 7 years.


RESULTS
There were 263 infants with isolated single umbilical artery and 41,415 infants with 3 vessel cords. A random effect model that controlled for potential confounders did not show clinically significant differences in the physical and neurodevelopment measures between these groups.


CONCLUSIONS
Our study shows no evidence of differential longitudinal physical growth or neurologic outcomes between infants with 2 or 3 vessel cords.
Chetty-John
Shilpa
S
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. schetty@stanford.edu
Zhang
Jun
J
Chen
Zhen
Z
Albert
Paul
P
Sun
Liping
L
Klebanoff
Mark
M
Grewal
Una
U
D000328:Adult; D001724:Birth Weight; D001827:Body Height; D001835:Body Weight; D016022:Case-Control Studies; D002508:Cephalometry; D002657:Child Development; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007361:Intelligence Tests; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008423:Maternal Age; D009483:Neuropsychological Tests; D011247:Pregnancy; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology; D012923:Social Class; D014469:Umbilical Arteries / Q000002:abnormalities*