[Pharmacological properties of complex iron oxide nanoparticles entering in magnetic resonance tomography contrast agent].
A colloidal solution of iron oxide nanoparticles has been obtained that ensures an increase in the accuracy of diagnostic information from magnetic resonance tomography (MRT) due to the acceleration of proton relaxation in tissues, which improves the contrast of T1- and T2-weighed images. Improved visualization of small vessels in rat brain has been observed after intravenous injection of 0.1 ml solution containing 5.0 mg of contrasting iron nanoparticles. The paramagnetic properties of iron oxide nanoparticles were studied by the method of proton relaxation, and their size was determined by the method of transmission electron microscopy. The toxic properties ofnanoparticles were determined by their effect on cultured HeLa cells (MTT test). It is recommended to use a colloidal solution of superparamagnetic nanoparticles (size, 8.2 nm) for obtaining a pharmaceutical form of the new magnetic-resonance contrast medium Ferotrast.
Akopdzhanov
A G
AG
Sergeev
A I
AI
Manvelov
E V
EV
Semeĭkin
A V
AV
Naumenko
V Iu
VIu
Panov
V O
VO
Bykov
I V
IV
Shimanovskiĭ
N L
NL
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000494:pharmacology; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles; D011859:Radiography; D051381:Rats
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide