title: Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties.
abstract: Original palladium complexes involving (-)-ephedrine, (-)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.
authors: Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, Université de Reims Champagne-Ardenne, BP 1039, 51687, Reims Cedex, France.
authors: Fabien
authors: F
authors: Accadbled
authors: Bernard
authors: B
authors: Tinant
authors: Eric
authors: E
authors: Hénon
authors: Danièle
authors: D
authors: Carrez
authors: Alain
authors: A
authors: Croisy
authors: Sandrine
authors: S
authors: Bouquillon
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010165:Palladium