Symptom cluster and physical activity in relapsing-remitting multiple sclerosis.
We compared the explanatory power of two symptom clusters that consisted of either three or five symptoms as correlates of physical activity in individuals with relapsing-remitting multiple sclerosis (RRMS; N = 218). The data were primarily analyzed using covariance modeling in Mplus 3.0. A symptom cluster of fatigue, depression, and pain had a moderate, negative relationship with physical activity, and this relationship was comparable in magnitude with a symptom cluster of fatigue, depression, pain, perceived cognitive dysfunction, and poor sleep quality. The relationships were attenuated after controlling for exercise history and neurological impairment. Such findings further support the consideration of a narrowly defined cluster of three symptoms as an independent correlate of physical activity in persons with RRMS.
Motl
Robert W
RW
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Weikert
Madeline
M
Suh
Yoojin
Y
Dlugonski
Deirdre
D
D000203:Activities of Daily Living; D000328:Adult; D000704:Analysis of Variance; D001294:Attitude to Health; D016000:Cluster Analysis; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015444:Exercise / Q000502:physiology / Q000523:psychology; D005163:Factor Analysis, Statistical; D005221:Fatigue / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006293:Health Promotion; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D015233:Models, Statistical; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000145:classification* / Q000150:complications* / Q000523:psychology; D015399:Nursing Research; D010146:Pain / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012044:Regression Analysis; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology