A genome-wide association study of self-rated health.
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.
Mosing
Miriam A
MA
Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Miriam.Mosing@qimir.edu.au
Verweij
Karin J H
KJ
Medland
Sarah E
SE
Painter
Jodie
J
Gordon
Scott D
SD
Heath
Andrew C
AC
Madden
Pamela A
PA
Montgomery
Grant W
GW
Martin
Nicholas G
NG
D000328:Adult; D000368:Aged; D001315:Australia; D005260:Female; D055106:Genome-Wide Association Study; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012647:Self-Assessment