title: Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae).
abstract: A new bioactive sterol glycoside, 3beta-O-(3',4'-di-O-acetyl-beta-D-arabinopyranosyl)-25xi-cholestane-3beta,5alpha,6beta,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
authors: Department of Life Science and Graduate Institute of Biotechnology, Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan. belle_ames@hotmail.com
authors: Chih-Yang
authors: CY
authors: Liu
authors: Tsong-Long
authors: TL
authors: Hwang
authors: Mei-Ru
authors: MR
authors: Lin
authors: Yung-Husan
authors: YH
authors: Chen
authors: Yu-Chia
authors: YC
authors: Chang
authors: Lee-Shing
authors: LS
authors: Fang
authors: Wei-Hsien
authors: WH
authors: Wang
authors: Yang-Chang
authors: YC
authors: Wu
authors: Ping-Jyun
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: C553816:3-O-(3',4'-di-O-acetylarabinopyranosyl)cholestane-3,5,6,26-tetrol-26-acetate; D000970:Antineoplastic Agents; D006027:Glycosides; D012503:Saponins; D013261:Sterols; D013481:Superoxides; D010196:Pancreatic Elastase