Perinatal bisphenol A exposure in C57B6/129svj male mice: potential altered cytokine/chemokine production in adulthood.
Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T(H)1 up-regulation more than T(H)2, and with skewing toward T(H)17 responses.
Holladay
Steven D
SD
Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA. sdholl@uga.edu
Xiao
Shuo
S
Diao
Honglu
H
Barber
Jamie
J
Nagy
Tomas
T
Ye
Xiaoqin
X
Gogal
Robert M
RM
D000818:Animals; D001559:Benzhydryl Compounds; D016207:Cytokines / Q000097:blood*; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D005260:Female; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D016207:Cytokines; D004968:Estrogens, Non-Steroidal; D008934:Mitogens; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds