Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes.
In recent decades, our knowledge of the genetics and functional genomics of drug-metabolizing enzymes has increased and a wealth of data on drug-related 'omics' has become available. Despite the availability of large amounts of biological information on xenobiotic biotransformation, the number of available biotransformation pathway maps that can easily be used for visualization of multiple omics data is limited. Here, we created integrated biotransformation pathway maps suitable for multiple omics analysis using PathVisio. The ease of visualizing data on these maps was demonstrated by using published microarray data from human hepatocyte-like cell models, exemplifying - where a sufficient capacity for metabolizing chemicals is a prerequisite for a suited model - how the biotransformation pathway maps can be used for model selection.
Jennen
Danyel G J
DG
Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands. danyel.jennen@grat.unimaas.nl
Gaj
Stan
S
Giesbertz
Pieter J
PJ
van Delft
Joost H M
JH
Evelo
Chris T
CT
Kleinjans
Jos C S
JC
D001711:Biotransformation; D016208:Databases, Factual; D006801:Humans; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012984:Software
D004364:Pharmaceutical Preparations