title: Type 1 electrocardiographic burden is increased in symptomatic patients with Brugada syndrome.
abstract: BACKGROUND
  Spontaneous type 1 electrocardiographic (ECG) is a risk factor for arrhythmic events in Brugada patients but the importance of the proportion of time with a type 1 ECG is unknown.
  
  
  METHODS
  Thirty-four Brugada patients (15 symptomatic) underwent a 24-hour 12-lead ECG recording. One-minute averaged waveforms displaying ST-segment elevation above 200 microV, with descending ST-segment and negative T-wave polarity on leads V(1)-V(3) were considered as type 1 Brugada ECG. The burden was defined as the percentage of type 1 Brugada waveforms.
  
  
  RESULTS
  Type 1 ECG on lead V2 was more frequent in symptomatic patients (median 80.6% [15.7-96.7] vs 12.4% [0.0-69.7], P = .05). Patients with a permanent type 1 pattern on lead V(2) were more likely to be symptomatic (5/6) than patients without type 1 ECG during a 24-hour period (2/9) (P < .05).
  
  
  CONCLUSIONS
  Type 1 pattern is more prevalent across a 24-hour period in symptomatic Brugada patients.
authors: Lariboisière Hospital APHP, University Paris Diderot, INSERM U942, Paris, France. fabrice.extramiana@lrb.aphp.fr
authors: Fabrice
authors: F
authors: Extramiana
authors: Pierre
authors: P
authors: Maison-Blanche
authors: Fabio
authors: F
authors: Badilini
authors: Anne
authors: A
authors: Messali
authors: Isabelle
authors: I
authors: Denjoy
authors: Antoine
authors: A
authors: Leenhardt
mesh_terms: D019540:Area Under Curve; D053840:Brugada Syndrome / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors