Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention.
We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P = .006 and P = .000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P = .045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = .015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.
Moohebati
Mohsen
M
Cardiovascular Research Center and Department of Biochemistry and Nutrition Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science, Mashhad, Iran.
Falsoleiman
Homa
H
Dehghani
Mashalla
M
Fazlinezhad
Afsoon
A
Daloee
Mehdi Hassanzadeh
MH
Esmaeili
Habib
H
Parizadeh
Seyyed Mohammad Reza
SM
Tavallaie
Shima
S
Rahsepar
Amir Ali
AA
Paydar
Roghayeh
R
Kazemi-Bajestani
Seyyed Mohammad Reza
SM
Pourghadam-Yari
Hossein
H
Rad
Mina Akbari
MA
Zoghdar-Moghadam
Talat
T
Ghayour-Mobarhan
Majid
M
Ferns
Gordon A
GA
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000906:Antibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D023921:Coronary Stenosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D054855:Drug-Eluting Stents; D004867:Equipment Design; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D008055:Lipids / Q000097:blood; D008297:Male; D008670:Metals; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D000099190:MAP-Kinase-Activated Kinase 2
D000906:Antibodies; D002097:C-Reactive Protein; D047908:Intracellular Signaling Peptides and Proteins; D008055:Lipids; D008670:Metals; D017346:Protein Serine-Threonine Kinases; D000099190:MAP-Kinase-Activated Kinase 2