title: Released intranasal eosinophilic major basic protein as a diagnostic marker for polypoid chronic rhinosinusitis.
abstract: OBJECTIVE
  To investigate the hypothesis that eosinophil major basic protein is released in high concentrations in the nasal mucus of patients with polypoid chronic rhinosinusitis.
  
  
  METHODS
  Single center, open, prospective trial.
  
  
  METHODS
  Medical University of Graz, Austria.
  
  
  METHODS
  Patients with polypoid chronic rhinosinusitis (n = 23) were compared to three different control groups: patients with chronic rhinosinusitis-like symptoms but without general mucosal thickening, patients who underwent functional endoscopic sinus surgery for reasons other than chronic rhinosinusitis, and patients without sinus disease (total n = 21). Mucus was harvested from each patient using a standardized technique and analyzed for eosinophil major basic protein with an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  In the patient group with polypoid chronic rhinosinusitis, 20 of 23 (87%) were positive for eosinophil major basic protein. In contrast, only one control patient was positive, whereas the remainder had no detectable amount of eosinophil major basic protein in the mucus (P < 0.001 vs chronic rhinosinusitis).
  
  
  CONCLUSIONS
  Toxic eosinophil major basic protein levels are elevated in polypoid chronic rhinosinusitis patients compared to control groups that have similar clinical presentations but upon closer examination turn out not to have chronic rhinosinusitis. In the future, the detection of eosinophil major basic protein in nasal mucus may become a sensitive and specific marker for chronic rhinosinusitis and a helpful diagnostic tool.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of Graz, Graz, Austria. christoph.schmid@meduni-graz.at
authors: Christoph
authors: C
authors: Schmid
authors: Walter
authors: W
authors: Habermann
authors: Hannes
authors: H
authors: Braun
authors: Markus
authors: M
authors: Gugatschka
authors: Brad S
authors: BS
authors: Oriel
authors: Janel A
authors: JA
authors: Smietana
authors: Heinz
authors: H
authors: Stammberger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D015331:Cohort Studies; D003937:Diagnosis, Differential; D047093:Eosinophil Major Basic Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism*; D009298:Nasal Polyps / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D012220:Rhinitis / Q000175:diagnosis* / Q000378:metabolism; D012852:Sinusitis / Q000175:diagnosis* / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D047093:Eosinophil Major Basic Protein