[CD47 and leukemia stem cells].
CD47, also known as integrin-associated protein (IAP), is an immunoglobulin-like protein. It can inhibit the phagocytosis of macrophages through binding with signal-regulatory protein alpha chain of inhibitory receptor on macrophage (SIRPα). The expression of CD47 on normal hematopoietic stem cells (HSCs) is useful for maintaining the stability of HSCs in body, but the high expression of CD47 existed on leukemia stem cell (LSCs) of AML patients which can reduce the macrophage-induced phagocytosis to LSCs and decrease the clearance of innate immune system of organism to LSCs. In this article, the expression and function of CD47 on HSCs and LSCs as well as the role of CD47 in the prognosis and target therapy of AML are reviewed.
Cheng
Qian-Song
QS
Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, Anhui Province, China.
Wang
Xing-Bing
XB
D051928:CD47 Antigen / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D010587:Phagocytosis
D051928:CD47 Antigen