title: The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity.
abstract: Anti-HER2/neu antibody therapy is reported to mediate tumor regression by interrupting oncogenic signals and/or inducing FcR-mediated cytotoxicity. Here, we demonstrate that the mechanisms of tumor regression by this therapy also require the adaptive immune response. Activation of innate immunity and T cells, initiated by antibody treatment, was necessary. Intriguingly, the addition of chemotherapeutic drugs, although capable of enhancing the reduction of tumor burden, could abrogate antibody-initiated immunity leading to decreased resistance to rechallenge or earlier relapse. Increased influx of both innate and adaptive immune cells into the tumor microenvironment by a selected immunotherapy further enhanced subsequent antibody-induced immunity, leading to increased tumor eradication and resistance to rechallenge. This study proposes a model and strategy for anti-HER2/neu antibody-mediated tumor clearance.
authors: Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China.
authors: SaeGwang
authors: S
authors: Park
authors: Zhujun
authors: Z
authors: Jiang
authors: Eric D
authors: ED
authors: Mortenson
authors: Liufu
authors: L
authors: Deng
authors: Olga
authors: O
authors: Radkevich-Brown
authors: Xuanming
authors: X
authors: Yang
authors: Husain
authors: H
authors: Sattar
authors: Yang
authors: Y
authors: Wang
authors: Nicholas K
authors: NK
authors: Brown
authors: Mark
authors: M
authors: Greene
authors: Yang
authors: Y
authors: Liu
authors: Jie
authors: J
authors: Tang
authors: Shengdian
authors: S
authors: Wang
authors: Yang-Xin
authors: YX
authors: Fu
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human