MTRR polymorphism and the risk for colorectal and breast cancer in Romanian patients--a preliminary study.
BACKGROUND
The risk of colorectal cancer (CRC) and breast cancer (BC) is influenced by polymorphisms located in the genes encoding enzymes of the folate pathway. The aim of this study was to evaluate if A66G MTRR (rs1801394) polymorphism is involved in predisposition for colorectal and breast carcinogenesis in Romanian patients.


METHODS
In the present case-control study, 300 individuals divide in four groups: sporadic CRC patients (n = 120), control CRC (n = 60), BC patients (n = 60) and control BC (n = 60), were genotyped by PCR-RFLP method.


RESULTS
Frequency of genotype AA was 11.7% in CRC control and 5% respectively in BC control. For cancer groups the frequency of genotype AA was 9.2% in CRC and 0% in BC.


CONCLUSIONS
Study results do not demonstrate an association between A66G MTRR polymorphism and CRC or BC in Romanian patients.
Burcoş
T
T
Surgical Departament, Colţea Hospital, Bucharest, Romania.
Toma
M
M
Stavarachi
M
M
Cimponeriu
D
D
Apostol
P
P
Popa
E
E
Stăñilescu
S
S
Popa
I
I
Radu
I
I
Serafinceanu
C
C
Panduru
N
N
Beluşică
L
L
Gavrilă
L
L
D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018570:Risk Assessment; D012307:Risk Factors; D012383:Romania
C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase