title: Cytotoxic prenylated flavonoids from Morus alba.
abstract: A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC(50) value of 0.64 μM against HeLa cells.
authors: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam.
authors: Nguyen Tien
authors: NT
authors: Dat
authors: Phung Thi Xuan
authors: PT
authors: Binh
authors: Le Thi Phuong
authors: le TP
authors: Quynh
authors: Chau
authors: C
authors: Van Minh
authors: Hoang Thanh
authors: HT
authors: Huong
authors: Jung Joon
authors: JJ
authors: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids