title: A randomized, multicenter, open-label clinical trial to assess the anamnestic immune response 4 to 8 years after a primary hepatitis B vaccination series.
abstract: This open-label, randomized study challenged 4- to 8-year-old children from Spain (N = 1478) with a single dose of hepatitis B vaccine to estimate anamnestic responses. At the time of preimmunization, 15.9% to 51.2% of subjects had antibody values ≥10 mIU/mL. One month postimmunization, 91.6% to 97.3% of subjects had antibody titers ≥10 mIU/mL. There were no serious, vaccine-related, adverse experiences, and no discontinuations as a result of adverse experience.
authors: CSISP, Centro Superior de Investigacion en Salud Publica (Center for Public Health Research), Valencia, Spain.
authors: Javier
authors: J
authors: Diez-Domingo
authors: Sheryl A
authors: SA
authors: Flores
authors: Jason C
authors: JC
authors: Martin
authors: Stephanie O
authors: SO
authors: Klopfer
authors: Florian P
authors: FP
authors: Schödel
authors: Prakash K
authors: PK
authors: Bhuyan
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D013030:Spain; D013997:Time Factors
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines