Haemolytic uraemic syndrome in a patient with acute lymphoblastic leukaemia.
We describe a patient diagnosed with haemolytic uraemic syndrome (HUS) during long-term maintenance therapy for childhood acute lymphoblastic leukaemia (ALL). He rapidly developed renal failure, hypertension and profound thrombocytopenia. Despite suffering a large intracerebral haemorrhage, he made a full recovery without residual neurological or renal deficit. His case raises the question of whether ALL or its treatments predispose an individual to developing HUS.
Clarke
Rachel T
RT
Department of Paediatric Haematology/Oncology, John Radcliffe Hospital, Oxford, UK. rachel.clarke@dphpc.ox.ac.uk
Mitchell
Chris
C
D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D013921:Thrombocytopenia / Q000150:complications / Q000628:therapy; D055815:Young Adult