title: Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
abstract: The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference and waist-hip ratio measurements and visceral fat area (VFA) that is measured by computed tomography (CT). There is evidence that waist circumference and waist-hip ratio in the Caucasian population are associated with variations in several genes, including neurexin 3 (NRXN3), transcription factor AP-2β (TFAP2B), methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes. To investigate the relationship between VFA and subcutaneous fat area (SFA) and these genes in the recruited Japanese population, we genotyped 8 single-nucleotide polymorphisms (SNPs) in these 6 genes from 1228 subjects. Multiple regression analysis revealed that gender, age, and rs1558902 and rs1421085 genotypes (additive model) in FTO were significantly associated with body mass index (BMI; P=0.0039 and 0.0039, respectively), SFA (P=0.0027 and 0.0023, respectively) and VFA (P=0.045 and 0.040, respectively). However, SNPs in other genes, namely, NRXN3, TFAP2B, MSRA, LYPLAL1 and MC4R were not significantly associated with BMI, SFA or VFA. Our data suggest that some SNPs, which were identified in genome-wide studies in the Caucasians, also confer susceptibility to fat distribution in the Japanese subjects.
authors: Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Japan. kikuko@src.riken.jp
authors: Kikuko
authors: K
authors: Hotta
authors: Michihiro
authors: M
authors: Nakamura
authors: Takahiro
authors: T
authors: Nakamura
authors: Tomoaki
authors: T
authors: Matsuo
authors: Yoshio
authors: Y
authors: Nakata
authors: Seika
authors: S
authors: Kamohara
authors: Nobuyuki
authors: N
authors: Miyatake
authors: Kazuaki
authors: K
authors: Kotani
authors: Ryoya
authors: R
authors: Komatsu
authors: Naoto
authors: N
authors: Itoh
authors: Ikuo
authors: I
authors: Mineo
authors: Jun
authors: J
authors: Wada
authors: Masato
authors: M
authors: Yoneda
authors: Atsushi
authors: A
authors: Nakajima
authors: Tohru
authors: T
authors: Funahashi
authors: Shigeru
authors: S
authors: Miyazaki
authors: Katsuto
authors: K
authors: Tokunaga
authors: Manabu
authors: M
authors: Kawamoto
authors: Hiroaki
authors: H
authors: Masuzaki
authors: Takato
authors: T
authors: Ueno
authors: Kazuyuki
authors: K
authors: Hamaguchi
authors: Kiyoji
authors: K
authors: Tanaka
authors: Kentaro
authors: K
authors: Yamada
authors: Toshiaki
authors: T
authors: Hanafusa
authors: Shinichi
authors: S
authors: Oikawa
authors: Hironobu
authors: H
authors: Yoshimatsu
authors: Kazuwa
authors: K
authors: Nakao
authors: Toshiie
authors: T
authors: Sakata
authors: Yuji
authors: Y
authors: Matsuzawa
authors: Yusuke
authors: Y
authors: Nakamura
authors: Naoyuki
authors: N
authors: Kamatani
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008297:Male; D051150:Methionine Sulfoxide Reductases / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D011859:Radiography; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D050656:Transcription Factor AP-2 / Q000235:genetics; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: C470072:MC4R protein, human; D009419:Nerve Tissue Proteins; D011506:Proteins; D044105:Receptor, Melanocortin, Type 4; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; C082354:neurexin IIIalpha; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase