title: Chronic viral hepatitis and chronic kidney disease.
abstract: Chronic kidney disease (CKD) has become a major public health problem worldwide over the past few decades because of the increasing prevalence of hypertension, diabetes mellitus, and elderly individuals in most countries. Chronic viral hepatitis (due to hepatitis B virus (HBV) and hepatitis C virus (HCV)) also poses significant morbidity and mortality globally. Both these viruses can cause CKD and these infections can occur as a consequence of CKD management. CKD patients acquiring HBV or HCV infection have higher morbidity and mortality rates, and the management of these infections among CKD patients with antiviral agents is associated with high rates of adverse effects. The optimal management of CKD associated with HBV and HCV is not well defined because of insufficient data from clinical trials. This review discusses the pathogenesis, clinical characteristics and management issues related to chronic viral hepatitis and CKD.
authors: Department of Internal Medicine, Singapore General Hospital, Singapore.
authors: Elias C
authors: EC
authors: Chacko
authors: Soondal Koomar
authors: SK
authors: Surrun
authors: T P
authors: TP
authors: Mubarack Sani
authors: Joseph M
authors: JM
authors: Pappachan
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002908:Chronic Disease; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy / Q000635:transmission; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000635:transmission; D006801:Humans; D007674:Kidney Diseases / Q000821:virology*
chemical_list: D000998:Antiviral Agents