Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma.
Radiotherapy is commonly used to treat oral squamous cell carcinoma (OSCC), but its therapeutic effects are unpredictable. To determine which genes correlate with radiation resistance in oral cancer, the authors evaluated radiation sensitivity using a standard colony formation assay with a gene microarray system for seven OSCC cell lines. They found significant associations between dozens of gene-expression levels and radiation resistance of OSCC cell lines. Following analysis of the different radiosensitive cancer cell lines, the friend leukaemia insertion (Fli)-1 gene was selected as a prediction marker gene for OSCC radiotherapy resistance. Fli-1 expression was associated with radiation resistance in OSCC patients. These data help to predict the effects radiation therapy has on OSCC, in turn contributing to the development of alternative radiation therapies.
Shintani
S
S
Department of Oral & Maxillofacial Surgery, Showa University School of Dentistry, Ota-ku, Tokyo, Japan. shintani@dent.showa-u.ac.jp
Hamakawa
H
H
Nakashiro
K
K
Shirota
T
T
Hatori
M
M
Tanaka
M
M
Kuroshita
Y
Y
Kurokawa
Y
Y
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000532:radiotherapy; D045744:Cell Line, Tumor; D020869:Gene Expression Profiling; D006801:Humans; D046228:Microarray Analysis; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000532:radiotherapy; D011237:Predictive Value of Tests; D051789:Proto-Oncogene Protein c-fli-1 / Q000378:metabolism*
D014408:Biomarkers, Tumor; C078433:FLI1 protein, human; D051789:Proto-Oncogene Protein c-fli-1