[Psychopharmacological therapy in mental retardation--comparison of the years 1991 and 2005].
OBJECTIVE
About psychopharmacological long-term care in individuals with mental retardation there are only a few data. The objective of this investigation was to analyze psychopharmacotherapy over a period of 15 years.


METHODS
For the year 1991 291 data sets and for the year 2005 288 data sets of all residents of a home for people with mental retardation were analysed.


RESULTS
The number of psychiatric disorders has not changed. But the frequency of medication with neuroleptics and antidepressive compounds has increased. Atypical and typical neuroleptics did not differ significantly in side effects. But the number of side effects in SSRI's is compared with tricyclic antidepressive compounds significantly reduced.


CONCLUSIONS
The present study is one of the few, which gives an overview of long-term course of psychiatric disorders in people with mental retardation, the psychopharmacological therapy und side effects of used medication.
Engel
Claudia
C
Klinik für Psychiatrie, Neurologie, Psychosomatik und Psychotherapie im Kindes- und Jugendalter, Universität Rostock, Rostock. claudia.engel@med.uni-rostock.de
Szrama
Elisabeth
E
Hässler
Frank
F
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D004363:Drug Utilization; D005260:Female; D005858:Germany; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D007360:Intelligence; D008134:Long-Term Care / Q000706:statistics & numerical data; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000523:psychology; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D012866:Skilled Nursing Facilities / Q000706:statistics & numerical data
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D011619:Psychotropic Drugs; D017367:Selective Serotonin Reuptake Inhibitors