[Per and post-natal medical management of congenital diaphragmatic hernia].
Congenital diaphragmatic hernia (CDH) is a 1 out of 3500 live-born malformation with persistent 30-40% mortality rate, related to severe pulmonary hypoplasia and hypertension. Better knowledge on the mechanisms inducing failure of adaptation at birth is a prerequisite for improving CDH prognosis. CDH is also associated with longterm morbidity, including prolonged respiratory failure, failure to growth, oral aversion, and scoliosis. Early prevention starting as soon as the first hours of life are required to reduced long term morbidity. The aims of the management are not only to reduce early mortality, related to persistent pulmonary hypertension, but also to prevent late morbidity.
Storme
L
L
Site de Lille, Hôpital Jeanne de Flandre, CHRU de Lille. lstorme@chru-lille.fr
Pennaforte
T
T
Rakza
T
T
Fily
A
A
Sfeir
R
R
Aubry
E
E
Bonnevalle
M
M
Fayoux
P
P
Deruelle
P
P
Houfflin-Debarge
V
V
Vaast
P
P
Depoortère
M-H
MH
Soulignac
B
B
Norel
N
N
Deuze
R
R
Deschildre
A
A
Thumerelle
C
C
Guimber
D
D
Gottrand
F
F
Benachi
A
A
De Lagausie
P
P
D004066:Digestive System Diseases / Q000209:etiology / Q000517:prevention & control; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D012140:Respiratory Tract Diseases / Q000209:etiology / Q000517:prevention & control