title: Recurrent infective endocarditis due to Aggregatibacter actinomycetemcomitans: reinfection or relapse?
abstract: Aggregatibacter actinomycetemcomitans is commonly part of the normal microflora of the human upper respiratory tract. It has been implicated in periodontal disease and various infections, particularly endocarditis. We report here what we believe to be the first case of recurrent infective endocarditis due to A. actinomycetemcomitans in a 44-year-old woman occurring 5 years after the initial episode. Genomic analysis proved that the strains were closely related. Despite efficient antibiotic treatment, surgery was necessary for recovery.
authors: AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.|AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
authors: Anais
authors: A
authors: Potron
authors: INSERM, UMR S 872 - Equipe 12, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Centre de Recherche Biomédical des Cordeliers, Université Paris Descartes et UPMC, Paris, France.|Université Paris Descartes, Faculté de Médecine, Paris, France.|AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.
authors: Jean-Luc
authors: JL
authors: Mainardi
authors: INSERM, UMR S 872 - Equipe 12, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Centre de Recherche Biomédical des Cordeliers, Université Paris Descartes et UPMC, Paris, France.|Université Paris Descartes, Faculté de Médecine, Paris, France.|AP-HP, Hôpital Européen Georges Pompidou, Service de Microbiologie, Paris, France.
authors: Isabelle
authors: I
authors: Podglajen
authors: AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
authors: Fabienne
authors: F
authors: Meunier
authors: Université Paris Diderot, Faculté de Médecine, Paris VII, France.|AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
authors: Marie-José
authors: MJ
authors: Sanson-le Pors
authors: Université Paris Diderot, Faculté de Médecine, Paris VII, France.|AP-HP, Hôpital Lariboisière, Service de Bactériologie - Virologie, Paris, France.
authors: Béatrice
authors: B
authors: Berçot
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D005260:Female; D016680:Genome, Bacterial; D006801:Humans; D015661:Pasteurellaceae / Q000145:classification* / Q000235:genetics; D016871:Pasteurellaceae Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents