title: A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
abstract: We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. abnetc@mail.nih.gov
authors: Christian C
authors: CC
authors: Abnet
authors: Neal D
authors: ND
authors: Freedman
authors: Nan
authors: N
authors: Hu
authors: Zhaoming
authors: Z
authors: Wang
authors: Kai
authors: K
authors: Yu
authors: Xiao-Ou
authors: XO
authors: Shu
authors: Jian-Min
authors: JM
authors: Yuan
authors: Wei
authors: W
authors: Zheng
authors: Sanford M
authors: SM
authors: Dawsey
authors: Linda M
authors: LM
authors: Dong
authors: Maxwell P
authors: MP
authors: Lee
authors: Ti
authors: T
authors: Ding
authors: You-Lin
authors: YL
authors: Qiao
authors: Yu-Tang
authors: YT
authors: Gao
authors: Woon-Puay
authors: WP
authors: Koh
authors: Yong-Bing
authors: YB
authors: Xiang
authors: Ze-Zhong
authors: ZZ
authors: Tang
authors: Jin-Hu
authors: JH
authors: Fan
authors: Chaoyu
authors: C
authors: Wang
authors: William
authors: W
authors: Wheeler
authors: Mitchell H
authors: MH
authors: Gail
authors: Meredith
authors: M
authors: Yeager
authors: Jeff
authors: J
authors: Yuenger
authors: Amy
authors: A
authors: Hutchinson
authors: Kevin B
authors: KB
authors: Jacobs
authors: Carol A
authors: CA
authors: Giffen
authors: Laurie
authors: L
authors: Burdett
authors: Joseph F
authors: JF
authors: Fraumeni
authors: Margaret A
authors: MA
authors: Tucker
authors: Wong-Ho
authors: WH
authors: Chow
authors: Alisa M
authors: AM
authors: Goldstein
authors: Stephen J
authors: SJ
authors: Chanock
authors: Philip R
authors: PR
authors: Taylor
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*
chemical_list: D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon