title: Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.
authors: Yonghua
authors: Y
authors: Guo
authors: Ky-Anh
authors: KA
authors: Nguyen
authors: Jan
authors: J
authors: Potempa
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism*; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D001422:Bacterial Adhesion / Q000502:physiology; D055113:Chronic Periodontitis / Q000276:immunology / Q000382:microbiology; D003167:Complement Activation; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D000080867:Gingipain Cysteine Endopeptidases; D005881:Gingiva / Q000382:microbiology; D006418:Heme / Q000378:metabolism; D006801:Humans; D057131:Immune Evasion / Q000502:physiology; D007113:Immunity, Innate / Q000502:physiology; D007249:Inflammation / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000201:enzymology*; D011489:Protein Denaturation; D044462:Receptors, Proteinase-Activated / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity; D037521:Virulence Factors
chemical_list: D018829:Adhesins, Bacterial; D023181:Antimicrobial Cationic Peptides; D000080867:Gingipain Cysteine Endopeptidases; D044462:Receptors, Proteinase-Activated; D037521:Virulence Factors; D006418:Heme; D003546:Cysteine Endopeptidases