[Influence of polyoxidonium on IL-1 beta, TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect].
It was established that in a mononuclear fraction polyoxidonium inhibited the TNF-alpha production and stimulated the IL-1 beta and IL-6 production. In LPS-induced mononuclear cultures polyoxidonium inhibited the IL-6 production and had no statistically significant effect on the synthesis of TNF-alpha and IL-1 beta. Polyoxidonium had no effect on TNF-alpha, IL-6 and IL-1 beta production by purified monocytes. The addition of polyoxidonium with dexamethasone to the cultures only in monocyte fraction enhanced the IL-1 beta production as compared with the effect of dexamethasone alone. Data obtained allow suggesting that under certain conditions polyoxidonium could alleviate pronounced suppressive influence of glucocorticoids on a secretory activity of effectors of innate immunity.
Geĭn
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Gorshkova
K G
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Geĭn
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D000328:Adult; D000893:Anti-Inflammatory Agents / Q000819:agonists / Q000494:pharmacology*; D003907:Dexamethasone / Q000819:agonists / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D010879:Piperazines / Q000819:agonists / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000893:Anti-Inflammatory Agents; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D010879:Piperazines; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha; D003907:Dexamethasone; C540909:azoximer bromide