title: Prediction of osteoconductive activity of modified potassium fluorrichterite glass-ceramics by immersion in simulated body fluid.
abstract: Potassium fluorrichterite (KNaCaMg(5)Si(8)O(22)F(2)) glass-ceramics were modified by either increasing the concentration of calcium (GC5) or by the addition of P(2)O(5) (GP2). The stoichiometric composition (GST), GC5 and GP2 were soaked in simulated body fluid (SBF) along with 45S5-type bioglass as a control. After immersion, surface analyses were performed using thin-film X-ray diffraction (TF-XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and Fourier-transform infrared (reflection) spectroscopy (FT-IR). All compositions showed the formation of a calcium phosphate rich surface layer in SBF; GST, GP2 and the bioglass control within 7 days of immersion and GC5 after 14 days. It was concluded that all compositions were likely to be osteoconductive in vivo, with GP2 providing the best performance in terms of the combination of rapid formation of the surface layer and superior mechanical properties. This glass-ceramic system has potential as a load bearing bioceramic for fabrication of medical devices intended for skeletal tissue repair.
authors: Centre for Biomaterials and Tissue Engineering, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK. Shashwat.bhakta@sth.nhs.uk
authors: Shashwat
authors: S
authors: Bhakta
authors: Deepak K
authors: DK
authors: Pattanayak
authors: Hiroaki
authors: H
authors: Takadama
authors: Tadashi
authors: T
authors: Kokubo
authors: Cheryl A
authors: CA
authors: Miller
authors: Mehdi
authors: M
authors: Mirsaneh
authors: Ian M
authors: IM
authors: Reaney
authors: Ian
authors: I
authors: Brook
authors: Richard
authors: R
authors: van Noort
authors: Paul V
authors: PV
authors: Hatton
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001826:Body Fluids / Q000378:metabolism / Q000502:physiology*; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology*; D005544:Forecasting; D007101:Immersion; D017633:Magnesium Silicates / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D050071:Bone Density Conservation Agents; D017633:Magnesium Silicates; C454689:fluorrichterite; C023506:Glass ceramics