Maternal diabetes and renal agenesis/dysgenesis.
BACKGROUND
Renal agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and renal agenesis.


METHODS
We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of renal agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records.


RESULTS
The odds of renal agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1-9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors.


CONCLUSIONS
Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for renal agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with renal malformations. Further study is warranted.
Davis
Erin M
EM
The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Peck
Jennifer David
JD
Thompson
David
D
Wild
Robert A
RA
Langlois
Peter
P
D016022:Case-Control Studies; D000013:Congenital Abnormalities / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D007674:Kidney Diseases / Q000151:congenital; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D012306:Risk; D012307:Risk Factors; D013781:Texas