[FOXO tanscription factor role in radiation adaptive response and hormisis in Drosophila melanogaster].
Previously we put forward a hypothesis about the role of FOXO-dependent mechanisms of stress-response gene activation after irradiation in radiation hormesis (Moskalev, 2008). To testify this assumption we analyze the influence of gamma-irradiation on duration of larvae development and imago lifespan in Drosophila strains with different FOXO function activity. We revealed that in FOXO hypomorphic allele homozygote strains the hormesis and adaptive response (increasing of larvae stage duration and longevity) were absent, in contrast to B wild type strain Canton-S and FOXO-heterozygotes.
Shaposhnikov
M V
MV
Moskalev
A A
AA
D000222:Adaptation, Physiological; D000818:Animals; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000528:radiation effects*; D005260:Female; D051858:Forkhead Transcription Factors / Q000502:physiology*; D005720:Gamma Rays; D007814:Larva / Q000254:growth & development / Q000528:radiation effects; D008297:Male; D013312:Stress, Physiological; D013997:Time Factors
D029721:Drosophila Proteins; C477334:FOXO protein, Drosophila; D051858:Forkhead Transcription Factors