title: The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients.
abstract: OBJECTIVE
  To determine the age of onset of type 1 diabetes that is most closely related to the subsequent development of a severe eating disorder such as anorexia nervosa (AN) or bulimia nervosa (BN).
  
  
  METHODS
  Participants were 53 female type 1 diabetes patients with AN or BN referred to our outpatient clinic from the Diabetes Center of Tokyo Women's Medical University. Forty-nine female type 1 diabetes patients who regularly visited the Diabetes Center and had no eating disorder-related problems constituted the 'direct control' group, whereas 941 female patients who for the first time visited the Diabetes Center constituted the 'historical control' group. The kernel function method was used to generate a density estimation of the onset age of each group and the chi-square test was used to compare the distribution.
  
  
  RESULTS
  The control groups had similar density shapes for the onset age of type 1 diabetes, but both differed from the 'eating disorder' group. For onset age 7-18 yr, the density of the 'eating disorder' group was higher than those of the control groups, but for the younger and older onset ages the densities were lower. The 'eating disorder' group developed type 1 diabetes significantly more frequently than the 'historical control' group between 7 and 18 yr of age (χ2 = 9.066, p < 0.011).
  
  
  CONCLUSIONS
  The development of type 1 diabetes in preadolescence or adolescence seems to place girls at risk for the subsequent development of AN or BN. Careful attention should be paid to these high-risk patients.
authors: Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. takii@cephal.med.kyushu-u.ac.jp
authors: Masato
authors: M
authors: Takii
authors: Yasuko
authors: Y
authors: Uchigata
authors: Junji
authors: J
authors: Kishimoto
authors: Chihiro
authors: C
authors: Morita
authors: Tomokazu
authors: T
authors: Hata
authors: Takehiro
authors: T
authors: Nozaki
authors: Keisuke
authors: K
authors: Kawai
authors: Yasuhiko
authors: Y
authors: Iwamoto
authors: Nobuyuki
authors: N
authors: Sudo
authors: Chiharu
authors: C
authors: Kubo
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000856:Anorexia Nervosa / Q000209:etiology*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000209:etiology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D011627:Puberty; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose