title: Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons.
abstract: Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the largest diameter were assessed by imaging. All patients were treated with breast-conserving surgery (quadrantectomy). ELIOT was delivered by two mobile linear accelerators immediately after breast resection with a single dose of 21 Gy. Local side effects of ELIOT were mainly liponecrosis (4.2%) and fibrosis (1.8%). After a mean follow-up of 36.1 months, 42 women (2.3%) developed a local recurrence, 24 (1.3%) a new primary ipsilateral carcinomas and 26 (1.4%) distant metastases as first event. Forty-six women died (2.5%), 28 for breast carcinoma and 18 for other causes. Five- and ten-year survivals were, respectively, 97.4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session.
authors: European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. umberto.veronesi@ieo.it
authors: Umberto
authors: U
authors: Veronesi
authors: Roberto
authors: R
authors: Orecchia
authors: Alberto
authors: A
authors: Luini
authors: Viviana
authors: V
authors: Galimberti
authors: Stefano
authors: S
authors: Zurrida
authors: Mattia
authors: M
authors: Intra
authors: Paolo
authors: P
authors: Veronesi
authors: Paolo
authors: P
authors: Arnone
authors: Maria Cristina
authors: MC
authors: Leonardi
authors: Mario
authors: M
authors: Ciocca
authors: Roberta
authors: R
authors: Lazzari
authors: Pietro
authors: P
authors: Caldarella
authors: Nicole
authors: N
authors: Rotmensz
authors: Claudia
authors: C
authors: Sangalli
authors: Daniele
authors: D
authors: Sances
authors: Patrick
authors: P
authors: Maisonneuve
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007430:Intraoperative Care; D007558:Italy; D053208:Kaplan-Meier Estimate; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome