Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese.
OBJECTIVE
To compare association of complement C3 (C3) and high sensitive C-reactive protein (hs-CRP) with insulin resistance.


METHODS
A total of 587 non-diabetic Chinese aged 20-80 years were recruited.


METHODS
Complement C3 and hs-CRP were measured by the rate nephelometry method and the particle enhanced immunoturbidimetric method, respectively, and their relationship to insulin resistance was assessed. Insulin resistance was defined as the upper quartile of HOMA2-IR.


RESULTS
Complement C3 and hs-CRP were significantly higher in subjects with insulin resistance than those without. Complement C3 was the second strongest determinant of insulin in the study (β = 0.34, P < 0.001). By regression analysis, C3 was significantly associated with insulin resistance (OR = 3.78, P < 0.05), independent of waist circumference and other metabolic risk factors; however, hs-CRP was not. Receiver operating characteristic curve analysis indicated the best model predicting insulin resistance was one that included C3 and waist circumference (AUC = 0.741, P < 0.05).


CONCLUSIONS
Compared to hs-CRP, serum C3 might be a better inflammatory marker of insulin resistance in the non-diabetic Chinese population.
Wang
Bangqiong
B
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Street, Chongqing 400016, China.
Li
Qifu
Q
Jiang
Yuanjuan
Y
Liu
Zhoujun
Z
Zhong
Li
L
Luo
Rong
R
Cheng
Qingfeng
Q
Qing
Hua
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
D015415:Biomarkers; D003176:Complement C3; D002097:C-Reactive Protein