Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33.
Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2-3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.
Raza
Muhammad Hashim
MH
National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Riazuddin
Sheikh
S
Drayna
Dennis
D
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003241:Consanguinity; D005192:Family Health; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D010154:Pakistan; D010375:Pedigree; D013342:Stuttering / Q000235:genetics*