title: Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease.
abstract: BACKGROUND
  Non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is an emerging risk factor for atherothrombosis.
  
  
  OBJECTIVE
  The aim of this study was to investigate the levels of MPV in subjects with NAFLD having no confounding factors for atherosclerosis such as obesity, diabetes mellitus, and hypertension. In addition, the possible relationship between MPV and carotid artery intima media thickness (CIMT), a well known marker of subclinical atherosclerosis, was also studied.
  
  
  METHODS
  MPV and CIMT levels were measured in 60 biopsy-proven NAFLD subjects and 54 healthy controls. Age and sex were similar between two groups.
  
  
  RESULTS
  Body mass index and waist circumference levels were higher in the NAFLD group when compared to the controls. There were no differences between the two groups regarding LDL cholesterol levels, whereas HDL cholesterol levels were lower in the NAFLD group. MPV and CIMT levels were not different between the two groups. According to the correlation analyses, CIMT levels were positively correlated to age in patients with NAFLD. However, no significant correlation was found between MPV and CIMT levels.
  
  
  CONCLUSIONS
  The results of this study do not show any difference in MPV levels between subjects with NAFLD and controls. These finding suggests that in the absence of other metabolic risk factors, MPV might not be involved in the mechanism(s) of increased cardiovascular risk in NAFLD.
authors: Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors: Guldem
authors: G
authors: Kilciler
authors: Halil
authors: H
authors: Genc
authors: Serkan
authors: S
authors: Tapan
authors: Fatih
authors: F
authors: Ors
authors: Muammer
authors: M
authors: Kara
authors: Nuri
authors: N
authors: Karadurmus
authors: C Nuri
authors: CN
authors: Ercin
authors: Yildirim
authors: Y
authors: Karslioglu
authors: Selim
authors: S
authors: Kilic
authors: Sait
authors: S
authors: Bagci
authors: M Kemal
authors: MK
authors: Erbil
authors: Teoman
authors: T
authors: Dogru
mesh_terms: D000328:Adult; D001706:Biopsy; D001792:Blood Platelets / Q000166:cytology* / Q000473:pathology; D002340:Carotid Artery Diseases / Q000097:blood* / Q000150:complications*; D016022:Case-Control Studies; D005234:Fatty Liver / Q000097:blood / Q000150:complications; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D015539:Platelet Activation; D012306:Risk; D013927:Thrombosis / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
chemical_list: D007328:Insulin