title: Heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication.
abstract: Hepatitis B virus infection is a worldwide epidemic and is closely associated with the development of hepatocellular carcinoma. Nevertheless, the molecular mechanisms of HBV infection and carcinogenesis remain elusive. Using a hepatocyte model of HBV infection and comparing the gene expression profiling analysis we found that heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 B1 (HS3ST3B1,3-OST3-B) is down-regulated in the hepatocytes of chronic HBV infection model. HS3ST3B1 showed potent inhibitory effect on HBV replication. The inhibitory effect of HS3ST3B1 overexpression was lost upon gene silencing of HS3ST3B1 or when a catalytic inactive mutant of HS3ST3B1 was expressed. Our study revealed the anti-viral activity of HS3ST3B1 on HBV replication. It is conceivable that possible therapeutic applications of HBV infection could be devised by manipulating HS3ST3B1 activity.
authors: The Key Laboratory of Molecular Biology in Infectious Diseases, Chongqing Medical University, Chongqing, China.
authors: Zhenzhen
authors: Z
authors: Zhang
authors: Xiang
authors: X
authors: Liu
authors: Juan
authors: J
authors: Chen
authors: Huaibin
authors: H
authors: Su
authors: Qiang
authors: Q
authors: Luo
authors: Jia
authors: J
authors: Ye
authors: Ni
authors: N
authors: Tang
authors: Wenlu
authors: W
authors: Zhang
authors: WeiXian
authors: W
authors: Chen
authors: Ben C B
authors: BC
authors: Ko
authors: Ailong
authors: A
authors: Huang
mesh_terms: D015536:Down-Regulation; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000201:enzymology* / Q000235:genetics / Q000821:virology; D022781:Hepatocytes / Q000201:enzymology / Q000821:virology; D006801:Humans; D009154:Mutation; D015238:Sulfotransferases / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D015238:Sulfotransferases; C102180:heparan sulfate D-glucosaminyl 3-O-sulfotransferase