Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain.
We recently demonstrated that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain to induce digestive neoplasia in dexamethasone-treated SCID mice was explored. SCID mice infected with C. parvum TUM1 strain developed a fulminant cryptosporidiosis associated with intramucosal adenocarcinoma, which is considered an early histological sign of invasive cancer. Both evidence of a role of C. parvum in adenocarcinoma induction and the extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum-induced gastro-intestinal cancer in humans should be assessed.
Certad
Gabriela
G
Laboratoire Biologie et Diversité des Pathogènes Eucaryotes Emergents (BDEEP), Institut Pasteur de Lille (IFR 142)-Université Lille Nord de France (EA4547), Lille, France. gabriela.certad@pasteur-lille.fr
Creusy
Colette
C
Guyot
Karine
K
Mouray
Anthony
A
Chassat
Thierry
T
Delaire
Baptiste
B
Pinon
Anthony
A
Sitja-Bobadilla
Ariadna
A
Alvarez-Pellitero
Pilar
P
Praet
Marleen
M
Cuvelier
Claude
C
Dei-Cas
Eduardo
E
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000818:Animals; D002278:Carcinoma in Situ / Q000473:pathology; D003457:Cryptosporidiosis / Q000150:complications*; D016785:Cryptosporidium parvum / Q000472:pathogenicity*; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D007414:Intestinal Neoplasms / Q000150:complications* / Q000473:pathology; D007484:Iowa; D051379:Mice; D016513:Mice, SCID