Late-onset group B streptococcal meningitis in a neonate with early antibiotic prophylaxis.
An otherwise healthy female baby who had received early postnatal antibiotic prophylaxis because of maternal vaginal group B streptococcal (GBS) colonization died of late-onset GBS meningitis. GBS was isolated from blood and cerebrospinal fluid. Genotyping using pulsed-field gel electrophoresis confirmed that the GBS isolates from the patient were identical to those from her mother's vagina. Susceptibility tests demonstrated no antibiotic resistance. This report provides additional microbiologic evidence indicating that early postnatal antibiotic prophylaxis is not effective in preventing late-onset GBS infections in neonates born to mothers with GBS colonization.
Ko
Ting-Jung
TJ
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: tengiong519@gmail.com.
Hsieh
Wu-Shiun
WS
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Hsueh
Po-Ren
PR
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chou
Hung-Chieh
HC
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Lu
Chun-Yi
CY
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
D019072:Antibiotic Prophylaxis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D013290:Streptococcal Infections / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D013292:Streptococcus agalactiae