title: Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions.
abstract: Methionine binding converts monofunctional platinum antitumor agents to trans configuration adducts in the reaction with DNA, which suggests the correlation of two classes of platinum complexes in the antitumor mechanism.
authors: Department of Chemistry, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China.
authors: Guolin
authors: G
authors: Ma
authors: Yuanzeng
authors: Y
authors: Min
authors: Fan
authors: F
authors: Huang
authors: Tao
authors: T
authors: Jiang
authors: Yangzhong
authors: Y
authors: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D005399:Fishes; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D013440:Sulfides; D004247:DNA