Well-defined and easily accessible yttrium complexes for enantioselective cyclisation of amines tethered to 1,2-di-substituted alkenes.
A straightforward in situ preparation of new chiral amido alkyl ate yttrium complexes is described. They catalysed the enantioselective cyclisation of 1,2-dialkyl-substituted aminopentenes in up to 77% ee, a significant value for this challenging transformation. Complex [(R)-L(0)][Y(CH(2)TMS)(2).Li(THF)(4)] undergoes C-H bond activation resulting in the formation of an original dimeric heterobimetallic yttrium complex which also acts as an active precatalyst.
Chapurina
Yulia
Y
Univ. Paris-Sud, Equipe de Catalyse Moléculaire, ICMMO, UMR 8182, Orsay, F-91405, France.
Hannedouche
Jérôme
J
Collin
Jacqueline
J
Guillot
Régis
R
Schulz
Emmanuelle
E
Trifonov
Alexander
A
D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D015019:Yttrium / Q000737:chemistry*
D000475:Alkenes; D000588:Amines; D009942:Organometallic Compounds; D015019:Yttrium