Ageing and neurodegenerative diseases.
Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation. Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens. In seeking to ameliorate ageing and age-related diseases, the search for anti-ageing drugs has been of much interest. Numerous studies have shown that the plant polyphenol, resveratrol (3,5,4'-trihydroxystilbene), extends the lifespan of several species, prevents age-related diseases, and possesses anti-inflammatory, and anti-cancer properties. The beneficial effects of resveratrol are believed to be associated with the activation of a longevity gene, SirT1. In this review, we discuss the pathogenesis of age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and cerebrovascular disease. The therapeutic potential of resveratrol, diet and the roles of stem cell therapy are discussed to provide a better understanding of the ageing mystery.
Hung
Chia-Wei
CW
Department of Neurology, Zhongxiao Branch, Taipei City Hospital/No 87, Tongde Rd, Nangang Dist, Taipei City 115, Taiwan.
Chen
Yu-Chih
YC
Hsieh
Wan-Ling
WL
Chiou
Shih-Hwa
SH
Kao
Chung-Lan
CL
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000503:physiopathology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol