Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus.
Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise training improves endothelial function but its effect on NO bioavailability in peripheral tissues during acute exercise stress in CVD is unclear. This paper will present evidence and discuss possible mechanisms by which NO delivery to peripheral tissues may be dysfunctional in diabetic subjects.
Stabler
Thomas
T
Duke University School of Medicine, Durham, North Carolina, USA.
Kenjale
Aarti
A
Ham
Katherine
K
Jelesoff
Nicole
N
Allen
Jason
J
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D003920:Diabetes Mellitus / Q000097:blood* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D014664:Vasodilation / Q000502:physiology*
D009569:Nitric Oxide