title: Three-year course of clinical symptomatology in young people at ultra high risk for transition to psychosis.
abstract: OBJECTIVE
  The investigation into the course of ultra high risk (UHR) symptomatology of those patients who eventually do not meet the psychosis-threshold criteria within the 3-year timeframe of the study.
  
  
  METHODS
  The course of UHR symptoms, GAF score and employment status was investigated in 57 patients who did not make a transition to psychosis and who were examined within the Dutch Prediction of Psychosis Study in Amsterdam, the Netherlands.
  
  
  RESULTS
  At the 3-year follow-up, 75% of the patients who did not make a transition to psychosis had remitted from UHR status. With a Generalized Estimation Equation Model it was shown that this group recovered from positive (F = 52.7, P < 0.0001), negative (F = 24.3, P < 0.0001), disorganization (F = 14.4, P < 0.0001) and general symptoms (F = 25.0, P < 0.0001) within the timeframe of the study. In addition, the level of global functioning and likelihood of having a job and/or education significantly improved. The largest improvements occurred within the first year. UHR symptoms did not re-occur after improvement.
  
  
  CONCLUSIONS
  With the current UHR criteria, a large percentage of the included subjects appear to have transitory complaints and dysfunctioning. A refinement of the UHR criteria may diminish the chance of including 'false positives' in future UHR studies.
authors: Department of Psychiatry, Academic Medical Centre, Amsterdam, the Netherlands. e.velthorst@amc.uva.nl
authors: E
authors: E
authors: Velthorst
authors: D H
authors: DH
authors: Nieman
authors: R M C
authors: RM
authors: Klaassen
authors: H E
authors: HE
authors: Becker
authors: P M
authors: PM
authors: Dingemans
authors: D H
authors: DH
authors: Linszen
authors: L
authors: L
authors: De Haan
mesh_terms: D000293:Adolescent; D004651:Employment / Q000523:psychology; D005069:Evaluation Studies as Topic; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008609:Mental Status Schedule / Q000592:standards*; D009426:Netherlands; D011379:Prognosis; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D012074:Remission Induction; D012306:Risk; D013997:Time Factors; D055815:Young Adult