Is metabolic syndrome a mild form of Cushing's syndrome?
The Metabolic Syndrome is a diagnosis of increasing prevalence that is noted to share multiple clinical features with Cushing's syndrome. Several studies suggest abnormalities in the Hypothalamic-Pituitary-Adrenal axis to be associated with this disease and tissue-specific hypercortisolemia is being investigated as a possible contributing factor. More research is needed to explore the relation between cortisol and the metabolic syndrome which, if confirmed, will have major therapeutic and public health implications.
Krikorian
Armand
A
Division of Clinical and Molecular Endocrinology, Case Western Reserve University, Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106, USA. Armand.Krikorian@UHhospitals.org
Khan
Mehreen
M
D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism
D042842:11-beta-Hydroxysteroid Dehydrogenases; D006854:Hydrocortisone