title: Positron emission tomography inter-scanner differences in dopamine D₂ receptor binding measured with [¹¹C]FLB457.
abstract: OBJECTIVE
  It is well known that the positron emission tomography (PET) system is subject to inter-scanner differences of regional radioactivity distribution. In the present study, the effect of inter-scanner difference of regional radioactivity on estimated binding potential (BP(ND)) of [¹¹C]FLB457 using the simplified reference tissue model (SRTM) was investigated.
  
  
  METHODS
  Each of the 11 subjects was given two PET scans using [¹¹C]FLB457, one each with both SET-3000 GCT/X (Shimadzu) and with ECAT EXACT HR+ (Siemens/CTI). In order to assess regional differences between the two scanners, estimated BP(ND) values in six volumes of interest (VOIs) by SRTM method were compared in both individual PET space and anatomical template space after anatomical normalization. Statistical voxel-by-voxel paired t test of BP(ND) images between SET-3000 GCT/X and ECAT EXACT HR+ was also performed.
  
  
  RESULTS
  Shapes of time-activity curves of the two PET scanners were slightly different in each VOI, with estimated BP(ND) values from ECAT EXACT HR+ appearing greater in the cerebral cortical regions and thalamus than that of SET-3000 GCT/X in both individual PET space and anatomical template space after anatomical normalization. Statistical voxel-by-voxel analysis showed similar tendency to BP(ND) value estimation, with greater BP(ND) values from ECAT EXACT HR+ than from SET-3000 GCT/X.
  
  
  CONCLUSIONS
  We demonstrated the inter-scanner differences in dopamine D(2) receptor binding measured with [¹¹C]FLB457. In particular, statistically significant differences of BP(ND) in certain regions were observed between two PET scanners, despite the subject groups being the same. Our results suggest that we reconsider the effect of the scanner model on the measurement of receptor binding.
authors: Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, Japan.
authors: Fumitoshi
authors: F
authors: Kodaka
authors: Hiroshi
authors: H
authors: Ito
authors: Miho
authors: M
authors: Shidahara
authors: Harumasa
authors: H
authors: Takano
authors: Hidehiko
authors: H
authors: Takahashi
authors: Ryosuke
authors: R
authors: Arakawa
authors: Kazuhiko
authors: K
authors: Nakayama
authors: Tetsuya
authors: T
authors: Suhara
mesh_terms: D000328:Adult; D016477:Artifacts; D002250:Carbon Radioisotopes; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D011485:Protein Binding; D011759:Pyrrolidines / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012457:Salicylamides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D002250:Carbon Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D012457:Salicylamides; C065065:FLB 457