[Analysis on epidemiological and serum effect after vaccination of hepatitis A vaccine (HepA)].
OBJECTIVE
To implement HepA vaccination and analyze epidemiological and serum effect.


METHODS
The children from 1 to 14 years old were vaccinated HepA since 1992 and the HepA has been integrated into EPI to the children aged 1 year in 1996. The enzyme linked immunnosortbent assay (ELISA) was used to detect Anti-Hepatitis A Virus IgG Antibody (Anti-HAV) to analyze serum effect.


RESULTS
HepA coverage rate from 1 to 14 years old was 80% in 1998, and it was > 90% after the year of 2001. The coverage of 1 year old children was 95%. The incidence rate of Hepatitis A reduced continuously. The incidence of whole population reduced from 25.96/100.000 in 1992 to 6.38/100.000 in 1994. In 2007, the incidence of Heptitis A decreased 98.10% compared with the incidence of the year of 1992. Epidemiological feature of Hepatitis A was changed. The positive rate of Anti-HAV was increased after vaccination of Hepatitis A Vaccine.


CONCLUSIONS
The vaccination strategy for 1 to 14 years old had obviously epidemiological and serum effect.
Li
Jian-ping
JP
Weifang Prefecture Centre for Disease Control and Prevention, Weifang 261041, Shandong, China.
Gao
Zhi-xia
ZX
Zhou
Jian
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006506:Hepatitis A / Q000097:blood* / Q000453:epidemiology* / Q000517:prevention & control; D035922:Hepatitis A Antibodies / Q000097:blood* / Q000276:immunology; D022362:Hepatitis A Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D014611:Vaccination
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines