title: Diagnosis of unknown primary cancer based on molecular techniques may influence therapeutic approach and improve survival.
abstract: Unknown primary cancer (UPC) is a common clinical syndrome classically associated with a poor prognosis. Pathological examination including immunohistochemistry continues to be essential in tumour origin characterization, although in many cases primary tumour site remains unknown. Gene expression based analysis may offer important diagnostic information that could lead to therapeutic decisions.
authors: Hospital Universitario 12 de Octubre, Madrid, Spain. blankihome@hotmail.com
authors: Blanca
authors: B
authors: Homet
authors: Ricardo
authors: R
authors: Hitt
authors: Ismael
authors: I
authors: Ghanem
authors: Hernán
authors: H
authors: Cortés-Funes
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000556:secondary*; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D013125:Spinal Neoplasms / Q000235:genetics / Q000556:secondary*