title: Use of brain electrical activity to quantify traumatic brain injury in the emergency department.
abstract: OBJECTIVE
  To validate a QEEG algorithm on traumatic brain injury in an Emergency Department (ED) setting.
  
  
  METHODS
  EEG data were collected from 105 patients with head injury (53 CT+ and 52 CT-) and 50 ED controls. Ten minutes of eyes closed resting EEG was collected from five frontal locations. A discriminant index of the probability of belonging to the TBI CT+ group was computed. Analysis of variance was computed comparing this index across the three patient groups. Using ROC curves, the p < 0.05 confidence level was determined to compute sensitivity and specificity for the TBI CT+ population.
  
  
  RESULTS
  CT+ patients had a mean TBI discriminant index of 80.4, CT- patients 38.9 and controls 24.5; F = 70.2, p < 0.0001. Sensitivity was 92.45% for the CT+ group and specificity was 90.00% for the control group.
  
  
  CONCLUSIONS
  The TBI discriminant index appears to be a sensitive index of brain function. It may be used to suggest whether or not a patient presenting with altered mental status requires a CT scan. This index may aid in the triage of such patients in the ED. Such an easy to use, automated system may greatly enhance the clinical utility of EEG in the ED.
authors: Washington University School of Medicine, St. Louis, MO 63110, USA. naunheir@wusm.wustl.edu
authors: Rosanne S
authors: RS
authors: Naunheim
authors: Matthew
authors: M
authors: Treaster
authors: Joy
authors: J
authors: English
authors: Teya
authors: T
authors: Casner
authors: Robert
authors: R
authors: Chabot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001930:Brain Injuries / Q000145:classification / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004569:Electroencephalography; D004636:Emergency Service, Hospital; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014481:United States; D055815:Young Adult