title: Proteasome-inhibitory and cytotoxic constituents of Garcinia lateriflora: absolute configuration of caged xanthones.
abstract: A new biflavonoid (1), a new xanthone enantiomer (2), five new caged xanthones (3-7), and several known compounds were isolated from the stem bark of Garcinia lateriflora, collected in Indonesia. The structures of the new compounds were determined by analysis of spectroscopic data, and the absolute configuration of the caged xanthones was shown for the first time at carbons 5, 7, 8, 8a, 10a, and 27, by analysis of COSY and NOESY NMR and ECD spectra. The biflavonoids exhibited proteasome inhibitory activity, and the known compound, morelloflavone (8) was found to have the greatest potency (IC(50) = 1.3 muM). The caged xanthones were cytotoxic towards HT-29 cells, with the known compound, morellic acid (10) being the most active (ED(50) = 0.36 muM). However, when tested in an in vivo hollow fiber assay, it was inactive at the highest dose tested (20 mg/kg).
authors: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
authors: Yulin
authors: Y
authors: Ren
authors: Daniel D
authors: DD
authors: Lantvit
authors: Esperanza J
authors: EJ
authors: Carcache de Blanco
authors: Leonardus B S
authors: LB
authors: Kardono
authors: Soedarsono
authors: S
authors: Riswan
authors: Heebyung
authors: H
authors: Chai
authors: Charles E
authors: CE
authors: Cottrell
authors: Norman R
authors: NR
authors: Farnsworth
authors: Steven M
authors: SM
authors: Swanson
authors: Yuanqing
authors: Y
authors: Ding
authors: Xing-Cong
authors: XC
authors: Li
authors: Jannie P J
authors: JP
authors: Marais
authors: Daneel
authors: D
authors: Ferreira
authors: A Douglas
authors: AD
authors: Kinghorn