Paraneoplastic glomerulopathy secondary to retroperitoneal sarcoma: a case report.
Glomerulopathy is a rare form of paraneoplastic disease. We present the second reported case of paraneoplastic glomerulopathy due to a retroperitoneal sarcoma. The patient presented with generalized edema and nephrotic syndrome. CT scan showed two large retroperitoneal masses. One large retroperitoneal mass was resected. Post-operatively, she developed kidney failure and biopsy showed minimal change disease. With steroid therapy, patient's symptoms went into remission. We hypothesize that minimal change paraneoplastic glomerulopathy developed due to damage from cytokines released from a T-cell mediated response to the malignancy.
Sherman
Jingjing L
JL
Division of General Surgery, Department of Surgery, The Mount Sinai Hospital, New York, New York, USA.
Liu
Eric Y
EY
Ozao-Choy
Junko
J
Winston
Jonathan A
JA
Lee
Johnny
J
Dikman
Steven H
SH
Divino
Celia M
CM
D000328:Adult; D005260:Female; D006801:Humans; D009402:Nephrosis, Lipoid / Q000150:complications; D010257:Paraneoplastic Syndromes / Q000150:complications; D012186:Retroperitoneal Neoplasms / Q000150:complications; D012509:Sarcoma / Q000150:complications*