title: Determination of pKa values of benzimidazole derivatives from mobility obtained by capillary electrophoresis.
abstract: Dissociation constants of benzimidazole derivatives have been determined using capillary zone electrophoresis (CZE). Since CZE is a separation method, high purity and known concentration for the samples is not necessary because only mobilities are measured. The precision of pK(a) measurements of seven compounds is useful to observe pK(a) shifts induced by chemical variations. Some of them were compared to potentiometry and spectroscopy experiments. Good correlated pK(a) values are observed between the three analytical techniques.
authors: Laboratoire de Chimie Analytique - EA 4481, Univ. Lille Nord de France, F-59000 Lille, France.
authors: Emmanuelle
authors: E
authors: Lipka
authors: Marcia
authors: M
authors: Folly-Klan
authors: Julie
authors: J
authors: Charton
authors: Marie-Pierre
authors: MP
authors: Vaccher
authors: Jean-Paul
authors: JP
authors: Bonte
authors: Claude
authors: C
authors: Vaccher
mesh_terms: D001562:Benzimidazoles / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods; D024202:Electrophoretic Mobility Shift Assay / Q000379:methods*; D006863:Hydrogen-Ion Concentration
chemical_list: D001562:Benzimidazoles; C031000:benzimidazole