Antimycobacterial and antitumor activities of palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)(2)].
Complexes of the type trans-[PdX(2)(isn)(2)] {X = Cl (1), N(3) (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of the isonicotinamide and the pseudohalide ligands was inferred by IR spectroscopy. Single crystal X-ray diffraction determination on 2 showed that coordination geometry around Pd(II) is nearly square planar, with the ligands in a trans configuration. All the compounds demonstrated better in vitro activity against Mycobacterium tuberculosis than isonicotinamide and pyrazinamide. Among the complexes, compound 2 was found to be the most active with MIC of 35.89 μM. Complexes 1-4 were also screened for their in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines.
de Souza
Rodrigo A
RA
Sao Paulo State Univ, Instituto de Química de Araraquara, Rua Prof. Francisco Degni s/n, C.P. 355, 14800-900 Araraquara, SP, Brazil.
Stevanato
Alessandra
A
Treu-Filho
Oswaldo
O
Netto
Adelino V G
AV
Mauro
Antonio E
AE
Castellano
Eduardo E
EE
Carlos
Iracilda Z
IZ
Pavan
Fernando R
FR
Leite
Clarice Q F
CQ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009536:Niacinamide / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D009536:Niacinamide; C027681:isonicotinamide; D010165:Palladium