Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
Zhang
Jiming
J
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
Li
Sheng
S
Zhang
Dehui
D
Wang
Hua
H
Whorton
A Richard
AR
Xian
Ming
M
D004220:Disulfides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*
D004220:Disulfides; D010720:Phosphines; D026403:S-Nitrosothiols; C044646:phosphine