Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients.
Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients.
Stellos
Konstantinos
K
Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universität Tübingen, Otfried-Mueller-Straße 10, Tübingen, Germany. konstantinos.stellos@med.uni-tuebingen.de
Panagiota
Victoria
V
Kögel
Andreas
A
Leyhe
Thomas
T
Gawaz
Meinrad
M
Laske
Christoph
C
D000544:Alzheimer Disease / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology*; D018450:Disease Progression; D005434:Flow Cytometry; D006801:Humans; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D011237:Predictive Value of Tests; D013997:Time Factors
D015415:Biomarkers; D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex