Synthesis and antiviral bioactivity of chiral thioureas containing leucine and phosphonate moieties.
A series of novel chiral thioureas 3a-n bearing leucine and phosphonate moieties were synthesized in excellent yields. The structures of the compounds were completely characterized by elemental analysis, IR, 1H-, 13C-, 31P- and 19F-NMR spectral data. A half-leaf method was used to determine the in vivo protective and curative efficacies of the title products against tobacco mosaic virus (TMV). The compounds 3l and 3n displayed good in vivo protection and curative effects against TMV with inhibitory rates of 60.1, 62.8% (protection) and 56.7, 53.6% (curative) at 0.5 mg/mL, respectively. To the best of our knowledge, this is the first report on the antiviral activity of chiral thioureas containing leucine and phosphonate moieties.
Liu
Jingzi
J
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China. liujingz@126.com
Yang
Song
S
Li
Xiangyang
X
Fan
Huitao
H
Bhadury
Pinaki
P
Xu
Weiming
W
Wu
Jian
J
Wang
Zhencao
Z
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D007930:Leucine / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D014027:Tobacco Mosaic Virus / Q000187:drug effects
D000998:Antiviral Agents; D063065:Organophosphonates; D012997:Solvents; D007930:Leucine; D013890:Thiourea