Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima.
A new tetracyclic bis-piperidine alkaloid, neopetrosiamine A (1), has been extracted from the marine sponge Neopetrosiaproxima collected off the west coast of Puerto Rico. The structure of compound 1 was elucidated by analysis of spectroscopic data coupled with careful comparisons of its (1)H and (13)C NMR data with those of a well-known 3-alkylbis-piperidine alkaloid model. The new alkaloid displayed strong in vitro cytotoxic activity against a panel of cancer cell lines as well as in vitro inhibitory activity against the pathogenic microbes Mycobacterium tuberculosis and Plasmodium falciparum.
Wei
Xiaomei
X
Department of Chemistry, University of Puerto Rico, PO Box 23346, UPR Station, San Juan 00931-3346, Puerto Rico.
Nieves
Karinel
K
Rodríguez
Abimael D
AD
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D017691:Caribbean Region; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009792:Oceans and Seas; D010880:Piperidines / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D010880:Piperidines; C555996:neopetrosiamine A; C032727:piperidine