title: Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 data.
abstract: Recent evidence suggests that endocrine disrupting chemicals (EDCs) may cause perturbations in endogenous hormonal regulation that predispose to weight gain. Using data from NHANES (1999-2002), we investigated the association between body mass index (BMI), waist circumference (WC) and selected persistent organic pollutants (POPs) via multiple linear regressions. Consistent interaction was found between gender, ln oxychlordane and ln p,p' DDT. Also, we found an association between WC and ln oxychlordane and ln hpcdd in subjects with detectable levels of POPs, whereas an association between WC and ln p,p' DDT was observed in all subjects. Furthermore, ln Ocdd showed an increase with higher WC and BMI, whereas, ln trans-nonachlor decreased with higher BMI. Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic.
authors: Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. maielobeid@gmail.com
authors: Mai A
authors: MA
authors: Elobeid
authors: Miguel A
authors: MA
authors: Padilla
authors: David W
authors: DW
authors: Brock
authors: Douglas M
authors: DM
authors: Ruden
authors: David B
authors: DB
authors: Allison
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D004147:Dioxins / Q000009:adverse effects*; D052244:Endocrine Disruptors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects*; D008297:Male; D009749:Nutrition Surveys; D009765:Obesity / Q000209:etiology*; D011634:Public Health; D012044:Regression Analysis; D014481:United States; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D004147:Dioxins; D052244:Endocrine Disruptors; D006843:Hydrocarbons, Chlorinated