title: Monitoring of poliovirus neutralizing antibodies in São Paulo State, Brazil.
abstract: As the world envisions poliomyelitis eradication, objective parameters are needed to ascertain whether immunocompetence against the virus provided by vaccine campaigns has been attained. The presence of neutralizing antibodies is considered a surrogate marker of protective immune response to the agent. Neutralization of three poliovirus serotypes were evaluated in a total of 411 sera samples collected from 1999 to 2005 in São Paulo State, Brazil. Antibody titres >/=1:8 were presented at 88.1% (362/411), 88.8% (365/411) and 61.6% (253/411) of samples for 1, 2 and 3 serotypes, respectively. Evaluation of poliovirus immune status may be a useful tool to support decisions concerning polio vaccine policy.
authors: Adolfo Lutz Institute, Virology, Enteric Viruses Laboratory, Avenida Dr Arnaldo, n degrees 355, CEP 01246-902, São Paulo, SP, Brazil. driluchs@gmail.com
authors: Adriana
authors: A
authors: Luchs
authors: Audrey
authors: A
authors: Cilli
authors: Denise H
authors: DH
authors: Russo
authors: Fernanda F
authors: FF
authors: Costa
authors: Rita de Cássia C
authors: Rde C
authors: Carmona
authors: Maria do Carmo S T
authors: Mdo C
authors: Timenetsky
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D001938:Brazil; D006801:Humans; D007121:Immunocompetence / Q000276:immunology; D009500:Neutralization Tests; D011051:Poliomyelitis / Q000276:immunology* / Q000517:prevention & control; D017955:Poliovirus / Q000276:immunology*; D011159:Population Surveillance; D015995:Prevalence
chemical_list: D000914:Antibodies, Viral