Cytotoxic prenylated flavonoids from Morus alba.
A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC(50) value of 0.64 μM against HeLa cells.
Dat
Nguyen Tien
NT
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam.
Binh
Phung Thi Xuan
PT
Quynh
Le Thi Phuong
le TP
Van Minh
Chau
C
Huong
Hoang Thanh
HT
Lee
Jung Joon
JJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids