title: Elevated sICAM-1 levels in patients with hemorrhagic fever with renal syndrome caused by Hantaan virus.
abstract: Increased vascular permeability and vascular leakage are characteristic pathological changes in hemorrhagic fever with renal syndrome (HFRS). Vascular endothelial cells are the main targets of Hantaan virus, the etiological agent of the severe form of HFRS. Hantaan virus can induce extensive damage of small blood vessels and capillaries. In vitro infection of human umbilical vein endothelial cells by Hantaan virus can induce the expression of intercellular adhesion molecule-1 (ICAM-1). The involvement of this molecule is implied in human HFRS. In the present study, serum-soluble ICAM-1 (sICAM-1) levels were determined and their relationships with the clinical course and disease severity were investigated in 112 HFRS patients and 30 healthy controls. The results showed that the serum levels of sICAM-1 in HFRS patients at fever, hypotensive, oliguric, and polyuric phases were significantly higher than those in controls (p < 0.001). However, no significant differences between the serum concentrations of sICAM-1 in the milder and more severe groups of patients were observed (p > 0.05). It is suggested that sICAM-1 was involved in the progression of HFRS. Time-dependent determinations of sICAM-1 levels may be indicators for the progression of disease, and elevated levels of sICAM-1 were not suggested to be correlated to disease severity.
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061 Shaanxi Province, China.
authors: Qunying
authors: Q
authors: Han
authors: Lei
authors: L
authors: Zhang
authors: Zhengwen
authors: Z
authors: Liu
authors: Wen
authors: W
authors: Kang
authors: Sai
authors: S
authors: Lou
authors: Jianming
authors: J
authors: Qiu
authors: Zhu
authors: Z
authors: Li
authors: Guoyu
authors: G
authors: Zhang
authors: Yawen
authors: Y
authors: Wang
authors: Man
authors: M
authors: Li
authors: Na
authors: N
authors: Li
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D018063:Hantaan virus / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D018799:Intercellular Adhesion Molecule-1