Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.
Ikedo
Akiyuki
A
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.
Hayakawa
Ichiro
I
Usui
Takeo
T
Kazami
Sayaka
S
Osada
Hiroyuki
H
Kigoshi
Hideo
H
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D007887:Fabaceae / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007529:Isoflavones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones; C521560:glaziovianin A