title: Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention.
abstract: We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P = .006 and P = .000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P = .045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = .015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.
authors: Cardiovascular Research Center and Department of Biochemistry and Nutrition Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science, Mashhad, Iran.
authors: Mohsen
authors: M
authors: Moohebati
authors: Homa
authors: H
authors: Falsoleiman
authors: Mashalla
authors: M
authors: Dehghani
authors: Afsoon
authors: A
authors: Fazlinezhad
authors: Mehdi Hassanzadeh
authors: MH
authors: Daloee
authors: Habib
authors: H
authors: Esmaeili
authors: Seyyed Mohammad Reza
authors: SM
authors: Parizadeh
authors: Shima
authors: S
authors: Tavallaie
authors: Amir Ali
authors: AA
authors: Rahsepar
authors: Roghayeh
authors: R
authors: Paydar
authors: Seyyed Mohammad Reza
authors: SM
authors: Kazemi-Bajestani
authors: Hossein
authors: H
authors: Pourghadam-Yari
authors: Mina Akbari
authors: MA
authors: Rad
authors: Talat
authors: T
authors: Zoghdar-Moghadam
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Gordon A
authors: GA
authors: Ferns
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000906:Antibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D023921:Coronary Stenosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D054855:Drug-Eluting Stents; D004867:Equipment Design; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D008055:Lipids / Q000097:blood; D008297:Male; D008670:Metals; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D000099190:MAP-Kinase-Activated Kinase 2
chemical_list: D000906:Antibodies; D002097:C-Reactive Protein; D047908:Intracellular Signaling Peptides and Proteins; D008055:Lipids; D008670:Metals; D017346:Protein Serine-Threonine Kinases; D000099190:MAP-Kinase-Activated Kinase 2