Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy.
to compare insulin-like growth factor binding protein-1 (IGFBP-1) (non-phosphorylated), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membrane to allow gestation-specific management.



we recruited 100 women with signs or symptoms of premature rupture of membranes (PROM), between 17 and 37 weeks at a tertiary referral center.



in 100 women in whom PAMG-1 was performed, sensitivity was 92.7%, specificity was 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) was 95.2%. IGFBP-1 was performed in 94 women, the sensitivity was 87.5%, specificity was 94.4%, PPV was 92.1% and NPV was 91.1%. In 98 women in whom nitrazine test was performed, the sensitivity was 85%, specificity was 39.7%, PPV was 49.3% and NPV was 79.3%.



PAMG-1 was the most accurate test in diagnosing rupture of membranes and had the highest sensitivity, specificity, PPVs and NPVs.
Tagore
Shephali
S
Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899. shephul@yahoo.com
Kwek
Kenneth
K
D000293:Adolescent; D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis*; D001391:Azo Compounds / Q000737:chemistry*; D016009:Chi-Square Distribution; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D011934:Reagent Strips; D012680:Sensitivity and Specificity; D055815:Young Adult
D000510:Alpha-Globulins; D001391:Azo Compounds; D018970:Insulin-Like Growth Factor Binding Protein 1; D011934:Reagent Strips; C016001:alpha-1-microglobulin; C013617:nitrazine yellow