Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers.
Colombia is a country with great geographic heterogeneity and marked regional differences in pre-Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X-Chromosome), maternal (mtDNA), and paternal (Y-chromosome) markers. Autosomal ancestry varies markedly both within and between regions, confirming the great genetic diversity of the Colombian population. The X-chromosome, mtDNA, and Y-chromosome data indicate that there is a pattern across regions indicative of admixture involving predominantly Native American women and European and African men.
Rojas
Winston
W
Laboratory of Molecular Genetics, Institute of Biology, University of Antioquia, Medellín, Colombia. winstonrojas@yahoo.com
Parra
María Victoria
MV
Campo
Omer
O
Caro
María Antonieta
MA
Lopera
Juan Guillermo
JG
Arias
William
W
Duque
Constanza
C
Naranjo
Andrés
A
García
Jharley
J
Vergara
Candelaria
C
Lopera
Jaime
J
Hernandez
Erick
E
Valencia
Ana
A
Caicedo
Yuri
Y
Cuartas
Mauricio
M
Gutiérrez
Javier
J
López
Sergio
S
Ruiz-Linares
Andrés
A
Bedoya
Gabriel
G
D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D003105:Colombia; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D005828:Genetics, Population / Q000379:methods*; D005843:Geography; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D044469:Racial Groups / Q000235:genetics*; D012737:Sex Factors
D004272:DNA, Mitochondrial; D005819:Genetic Markers