Relationship between leptin, adiponectin, bone mineral density, and measures of adiposity among pre-menopausal Hispanic and Caucasian women.
OBJECTIVE
The purpose of this study was to examine the relationship between fasting serum leptin and adiponectin levels with bone mineral density (BMD) and body composition in pre-menopausal, middle-aged Hispanic and Caucasian women.


OBJECTIVE
Participants' (68 Hispanic and 36 Caucasian) BMD and bone mineral content were measured by dual-energy X-ray absorptiometry, and body density was measured by hydrodensitometry. Serum leptin was determined by enzyme immunoassay and adiponectin by ELISA.


RESULTS
Hispanic women had significantly higher leptin, BMD, and fat mass (FM), and lower adiponectin than Caucasian women. There was no significant correlation between leptin and BMD for Hispanic or Caucasian women; adiponectin was inversely correlated with BMD in Caucasian women only (p = 0.01). In both Hispanic and Caucasian women, lean body mass and adiponectin best explained the variance in BMD (r(2) = 0.25, p < 0.001).


CONCLUSIONS
These data demonstrate no significant relationship between leptin and BMD of pre-menopausal, middle-aged Hispanic and Caucasian women, and a significant inverse relationship between adiponectin and BMD in Caucasian women. The role of adipocytokines in the regulation of BMD remains inconclusive and may vary across ethnic groups.
King
George A
GA
Department of Kinesiology, University of Texas at El Paso, El Paso, Texas 79902, USA. gking@utep.edu
Deemer
Sarah E
SE
Thompson
Dixie L
DL
D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000704:Analysis of Variance; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D005215:Fasting; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D017697:Premenopause / Q000502:physiology; D012044:Regression Analysis; D044465:White People
D052242:Adiponectin; D020738:Leptin