Artificial, switchable K+-gated ion channels based on flow-through titania-nanotube arrays.
In the present work, we demonstrated a novel type of artificial K(+)-gated ion channels based on titania nanotubes loaded with Au nanoparticles and G-rich DNA composite structure. K(+) promoted conformational change of G-rich DNA from flexible chain to rigid quadruplex, which provided a blocking effect for the transport of anions such as Fe(CN)(6)(4-) and other molecules through the channels in TiO(2) nanotubes. This fabricated permselective membrane using K(+) as a trigger may set light to the field of biosensing, drug-release, ion exchange membrane and so on.
Zhu
Bin
B
State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China.
Li
Jingjian
J
Chen
Qingwei
Q
Cao
Rui-Guo
RG
Li
Jianming
J
Xu
Dongsheng
D
D032701:Biomimetics / Q000379:methods*; D004563:Electrochemistry; D004566:Electrodes; D054856:G-Quadruplexes / Q000187:drug effects; D006046:Gold / Q000737:chemistry; D015640:Ion Channel Gating; D053768:Metal Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000295:instrumentation*; D043942:Nanotubes; D011188:Potassium / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism*; D014025:Titanium / Q000737:chemistry*
D015221:Potassium Channels; C009495:titanium dioxide; D006046:Gold; D014025:Titanium; D011188:Potassium