title: Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction.
abstract: The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n=8) or trained (trained HFD, n=8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n=8) or trained (trained ER, n=8). Trained rats ran on a treadmill at 55% VO(2max) for 60 min/day, 5 days/week, for 10 weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-α levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-α and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r=0.464), TNF-α (r=0.508); and adiponectin (r=0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect.
authors: Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Alex Shimura
authors: AS
authors: Yamashita
authors: Fábio Santos
authors: FS
authors: Lira
authors: José Cesar
authors: JC
authors: Rosa
authors: Ellena Christina
authors: EC
authors: Paulino
authors: Patrícia Chakur
authors: PC
authors: Brum
authors: Carlos Eduardo
authors: CE
authors: Negrão
authors: Ronaldo Vagner
authors: RV
authors: dos Santos
authors: Miguel Luiz
authors: ML
authors: Batista
authors: Claudia Oller
authors: CO
authors: do Nascimento
authors: Lila Missae
authors: LM
authors: Oyama
authors: Marília
authors: M
authors: Seelaender
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D002149:Energy Intake; D016014:Linear Models; D008297:Male; D009765:Obesity / Q000378:metabolism*; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D054392:Adipokines; D052242:Adiponectin