A facile synthesis of 3-substituted 9H-pyrido[3,4-b]indol-1(2H)-one derivatives from 3-substituted beta-carbolines.
A mild and efficient two-step synthesis of 3-substituted beta-carbolinone derivatives from 3-substituted beta-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of beta-carbolin-1-one is proposed. The structures of these compounds were established by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.
Lin
Guowu
G
College of Basic Science, China Pharmaceutical University, Nanjing 210009, China.
Wang
Yue
Y
Zhou
Qingfa
Q
Tang
Weifang
W
Wang
Jian
J
Lu
Tao
T
D002243:Carbolines / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D013997:Time Factors
D002243:Carbolines; D007211:Indoles