title: The hypothalamic-pituitary-adrenal axis in women with differentiated thyroid cancer.
abstract: BACKGROUND
  We studied the function of hypothalamic-pituitary-adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk.
  
  
  RESULTS
  Sixteen women were investigated with (1) morning, evening, and midnight cortisol and adrenocortophic hormone, (2) cortisol after overnight 1 mg dexamethasone suppression test, (3) cortisol after corticotropin releasing hormone test, (4) oral glucose tolerance test with glucose and insulin estimations, and (5) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls.
  
  
  CONCLUSIONS
  Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls.
authors: Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece. alexri@otenet.gr
authors: Alexandra
authors: A
authors: Chrisoulidou
authors: Kalliopi
authors: K
authors: Pazaitou-Panayiotou
authors: Eleni
authors: E
authors: Georgiou
authors: Maria
authors: M
authors: Boudina
authors: Konstantinos
authors: K
authors: Lytras
authors: Ioannis
authors: I
authors: Iakovou
authors: Iraklis
authors: I
authors: Vainas
authors: Gregory
authors: G
authors: Kaltsas
mesh_terms: D018263:Adenocarcinoma, Follicular; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002277:Carcinoma; D002291:Carcinoma, Papillary; D002318:Cardiovascular Diseases / Q000150:complications; D002940:Circadian Rhythm; D003346:Corticotropin-Releasing Hormone; D003907:Dexamethasone; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone