title: Rank Protein Immunolabeling during Bone-Implant Interface Healing Process.
abstract: The purpose of this paper was to evaluate the expression of RANK protein during bone-healing process around machined surface implants. Twenty male Wistar rats, 90 days old, after having had a 2 mm diameter and 6 mm long implant inserted in their right tibias, were evaluated at 7, 14, 21, and 42 days after healing. After obtaining the histological samples, slides were subjected to RANK immunostaining reaction. Results were quantitatively evaluated. Results. Immunolabeling analysis showed expressions of RANK in osteoclast and osteoblast lineage cells. The statistical analysis showed an increase in the expression of RANK in osteoblasts at 7 postoperative days and a gradual decrease during the chronology of the healing process demonstrated by mild cellular activity in the final stage (P < .05). Conclusion. RANK immunolabeling was observed especially in osteoclast and osteoblast cells in primary bone during the initial periods of bone-healing/implant interface.
authors: Department of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, Brazil.
authors: Francisley
authors: F
authors: Avila Souza
authors: Thallita
authors: T
authors: Pereira Queiroz
authors: Eloá
authors: E
authors: Rodrigues Luvizuto
authors: Renato Sussumu
authors: RS
authors: Nishioka
authors: Idelmo Rangel
authors: IR
authors: Garcia
authors: Paulo Sérgio Perri
authors: PS
authors: de Carvalho
authors: Roberta
authors: R
authors: Okamoto