title: Cartilage biology, pathology, and repair.
abstract: Osteoarthritis is one of the most common forms of musculoskeletal disease and the most prominent type of arthritis encountered in all countries. Although great efforts have been made to investigate cartilage biology and osteoarthritis pathology, the treatment has lagged behind that of other arthritides, as there is a lack of effective disease-modifying therapies. Numerous approaches for dealing with cartilage degradation have been tried, but enjoyed very little success to develop approved OA treatments with not only symptomatic improvement but also structure-modifying effect. In this review we discuss the most recent findings regarding the regulation of cartilage biology and pathology and highlight their potential therapeutic values.
authors: Institute of Experimental Musculoskeletal Medicine IEMM, University Hospital Muenster, Domagkstrasse 3, 48149, Muenster, Germany.
authors: Daniel
authors: D
authors: Umlauf
authors: Svetlana
authors: S
authors: Frank
authors: Thomas
authors: T
authors: Pap
authors: Jessica
authors: J
authors: Bertrand
mesh_terms: D002356:Cartilage / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D019902:Chondrocytes / Q000378:metabolism; D016207:Cytokines / Q000276:immunology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007596:Joints / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology; D010003:Osteoarthritis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012038:Regeneration / Q000502:physiology
chemical_list: D016207:Cytokines