Macrocyclic G-quadruplex ligands.
G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are reviewed here with special attention to selectivity and structure-activity relationships, and with focus on the recent developments.
Nielsen
M C
MC
Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark.
Ulven
T
T
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D016615:Telomere / Q000737:chemistry
D000970:Antineoplastic Agents; D008024:Ligands; D047028:Macrocyclic Compounds; D010080:Oxazoles; D011166:Porphyrins; C431888:telomestatin