title: Bilateral, wide-spread, mechanical pain sensitivity in children with frequent episodic tension-type headache suggesting impairment in central nociceptive processing.
abstract: BACKGROUND
  The aim was to investigate bilateral, wide-spread pressure pain hyperalgesia in symptomatic (trigeminocervical) and non-symptomatic (pain-free distant) regions in children with frequent episodic tension-type headache (FETTH).
  
  
  METHODS
  Twenty-five children, 6 boys and 19 girls (mean age, 8.9 +/- 1.8 years) with FETTH and 50 age- and sex-matched healthy children (12 boys, 38 girls; mean age: 8.8 +/- 1.7 years) were recruited. Pressure pain thresholds (PPTs) were bilaterally assessed over temporalis muscle, upper trapezius muscle, second metacarpal and tibialis anterior muscles in a blinded design.
  
  
  RESULTS
  The results showed that PPT levels were significantly decreased bilaterally over the temporalis, upper trapezius and tibialis muscles, and the second metacarpal in children with FETTH as compared to controls (all sites, P < 0.001). No significant differences in the magnitude of PPT decrease between the upper trapezius muscle, second metacarpal and tibialis anterior muscles were found. PPT over both upper trapezius muscles were negatively correlated with the history and intensity of headache (r(s) = -0.415; P = 0.045).
  
  
  CONCLUSIONS
  The findings revealed bilateral, wide-spread pressure pain hypersensitivity in children with FETTH suggesting that wide-spread central sensitisation is involved in children with this headache pain condition.
authors: Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain. cesar.fernandez@urjc.es
authors: César
authors: C
authors: Fernández-de-Las-Peñas
authors: Daniel M
authors: DM
authors: Fernández-Mayoralas
authors: Ricardo
authors: R
authors: Ortega-Santiago
authors: Silvia
authors: S
authors: Ambite-Quesada
authors: Antonio
authors: A
authors: Gil-Crujera
authors: Alberto
authors: A
authors: Fernández-Jaén
mesh_terms: D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D008297:Male; D009619:Nociceptors / Q000502:physiology*; D017288:Pain Threshold / Q000502:physiology*; D011312:Pressure; D013703:Temporal Muscle / Q000294:innervation / Q000503:physiopathology; D018781:Tension-Type Headache / Q000503:physiopathology*; D014276:Trigeminal Nerve / Q000503:physiopathology