title: Churg-Strauss syndrome: a retrospective study of 11 cases from a single center in Japan.
abstract: OBJECTIVE
  To investigate the clinical characteristics of patients with Churg-Strauss syndrome (CSS), including symptoms, blood chemistry and immunological findings.
  
  
  METHODS
  We retrospectively investigated the records of 11 patients (six female and five male) with CSS admitted to our hospital from September 2003 to October 2009.
  
  
  RESULTS
  Eight patients had preceding symptoms including bronchial asthma and allergic rhinitis. Seven patients showed eosinophilia. Nine patients had mononeuritis multiplex. Positive findings of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) were found in five patients. Neither clinical manifestations nor laboratory findings were correlated with positivity for MPO-ANCA. However, the MPO-ANCA-positive group showed a higher level of blood urea nitrogen and proteinuria than those negative for MPO-ANCA. Ten patients recovered after starting steroid or immunosuppressive therapy, although one patient died of unknown etiology.
  
  
  CONCLUSIONS
  Although general assessments based on various factors such as medical history, clinical manifestation and laboratory studies are indispensable in CSS, MPO-ANCA might be useful as a predictor of renal dysfunction in patients with CSS.
authors: Department of Internal Medicine and Rheumatology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. yoshirohorai0518@qmed.hosp.go.jp
authors: Yoshiro
authors: Y
authors: Horai
authors: Tomoya
authors: T
authors: Miyamura
authors: Akie
authors: A
authors: Hirata
authors: Masataka
authors: M
authors: Nakamura
authors: Soichiro
authors: S
authors: Takahama
authors: Hitoshi
authors: H
authors: Ando
authors: Rumi
authors: R
authors: Minami
authors: Masahiro
authors: M
authors: Yamamoto
authors: Eiichi
authors: E
authors: Suematsu
mesh_terms: D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001249:Asthma / Q000276:immunology; D001806:Blood Urea Nitrogen; D015267:Churg-Strauss Syndrome / Q000097:blood / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007564:Japan; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D011507:Proteinuria / Q000276:immunology; D012189:Retrospective Studies; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D013256:Steroids; D009195:Peroxidase