Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety.
Resveratrol (RVT) is a naturally occurring trihydroxy stilbene that displays a wide spectrum of physiological activity. Its ability to behave therapeutically as a component of red wine has attracted wide attention. The phenol acts as a protective agent involving various body constituents. Most attention has been given to beneficial effects in insults involving cancer, aging, cardiovascular system, inflammation and the central nervous system. One of the principal modes of action appears to be as antioxidant. Other mechanistic pathways entail cell signaling, apoptosis and gene expression. There is an intriguing dichotomy in relation to pro-oxidant property. Also discussed are metabolism, receptor binding, rationale for safety and suggestions for future work. This is the first comprehensive review of RVT based on a broad, unifying mechanism.
Kovacic
Peter
P
Department of Chemistry, San Diego State University, San Diego, CA, USA. pkovacic@sundown.sdsu.edu
Somanathan
Ratnasamy
R
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013267:Stilbenes / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol