Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters.
All-carbon quaternary stereocenters are ubiquitous motifs in biological products and pharmaceutical agents. However, due to sterical reasons, these centers are not always easily accessible. The metal-catalyzed conjugate addition reaction to trisubstituted conjugated substrates presents a viable methodology to create quaternary centers. In this article, different ways of activating the conjugate system towards nucleophilic addition will be described. An overview will be given on the different types of quaternary centers that are accessible through the conjugate addition reaction.
Hawner
Christine
C
Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland.
Alexakis
Alexandre
A
D002384:Catalysis; D007202:Indicators and Reagents; D008670:Metals / Q000737:chemistry*; D013237:Stereoisomerism
D007202:Indicators and Reagents; D008670:Metals