DNA methylation biomarkers in serum for gastric cancer screening.
Epigenetic alterations occur throughout the development and carcinogenesis of gastric cancer. Therefore, the detection of methylated DNA markers is predicted to be able to detect gastric cancer earlier, and improve the risk assessment, surveillance, relapse, and prognosis of patients with gastric cancer. Detection of free methylated DNA also represents a promising approach for developing serum-based detection methods for the non-invasive monitoring of gastric cancer progression.
Ye
Ting
T
Department of Gastroenterology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, P.R. China.
Chen
Yingxuan
Y
Fang
Jingyuan
J
D014408:Biomarkers, Tumor / Q000097:blood*; D019175:DNA Methylation; D055088:Early Detection of Cancer; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor