title: [A case of breast meningeal carcinomatosis caused by trastuzumab treatment as adjuvant chemotherapy].
abstract: A 52-year-old woman underwent modified radical mastectomy and axillary lymph node resection for right breast cancer (stage IIB). Afterwards FEC therapy (5-FU 500 mg/m/2, epirubicin 75 mg/m2, cyclophosphamide 500 mg/m2) x 4, docetaxel therapy (60 mg/m2) x 4 and radiation of the illness side collarbone, upper and lower lymph nodes were enforced for adjuvant therapy after the operation. Furthermore, administration of aromatase inhibitor (anastrozole) and trastuzumab was started due to the postoperative pathological diagnosis of hormone receptor-positive and HER2 (score 3+). This became an urgent hospital admission because of the sudden escape power from impaired consciousness due to the articulation disorders and limb weakness when trastuzumab was administered nine times. It was diagnosed by MRI examination and the cerebrospinal fluid cytology as meningeal carcinomatosis of breast cancer, and she died on the 31st recurrence of disease. A serious relapse may be caused in a case of fast-progressing breast cancer like this while being administered trastuzumab as an adjuvant treatment.
authors: Breast Care Center, National Hospital Organization Kyushu Medical Center.
authors: Hiroki
authors: H
authors: Takahashi
authors: Teruhiko
authors: T
authors: Fujii
authors: Yuka
authors: Y
authors: Inoue
authors: Masakazu
authors: M
authors: Katsura
authors: Goro
authors: G
authors: Yokoyama
authors: Roka
authors: R
authors: Matsubayashi  Namoto
authors: Yoshifuku
authors: Y
authors: Nakayama
authors: Seiya
authors: S
authors: Momosaki
authors: Hiroshi
authors: H
authors: Ariyama
authors: Miki
authors: M
authors: Takenaka
authors: Hiroko
authors: H
authors: Otsuka
authors: Nobutaka
authors: N
authors: Iwakuma
authors: Uhi
authors: U
authors: Toh
authors: Kazuo
authors: K
authors: Shirouzu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D055756:Meningeal Carcinomatosis / Q000188:drug therapy / Q000556:secondary*; D008875:Middle Aged; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068878:Trastuzumab