title: Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni).
abstract: Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.
authors: University of Glasgow, Scotland, UK.
authors: Joyce
authors: J
authors: Thornhill
authors: John
authors: J
authors: Kusel
authors: Fabricia Alvisi de
authors: FA
authors: Oliviera
authors: Fabio
authors: F
authors: Ribeiro
authors: Symone Fulgêncio
authors: SF
authors: Lima
authors: Paulo Marcos Zech
authors: PM
authors: Coelho
authors: Paul
authors: P
authors: McVeigh
authors: Ana Carolina Alves
authors: AC
authors: Mattos
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000378:metabolism*; D006790:Host-Parasite Interactions / Q000502:physiology*; D007546:Isoquinolines / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D011419:Propidium / Q000378:metabolism; D012550:Schistosoma mansoni / Q000254:growth & development*; D012867:Skin / Q000469:parasitology*
chemical_list: D005456:Fluorescent Dyes; D007546:Isoquinolines; D011419:Propidium; C017475:lucifer yellow