[Antioxidant efficacy in the treatment of cardiac metabolism disorders during endotoxicosis].
Chronic experiments on dogs showed that antioxidant drugs (reamberin, ximedone, vitamin E) are highly effective in correcting the functional and metabolic disorders in myocardium under endogenous intoxication conditions. Recovery of the functional activity was accompanied by correction of the lipid metabolism of cardiac cell structures. One mechanism of the drug action is related to a decrease in the lipid peroxidation rate and phospholipase A2 activity in cardiac tissue structures.
Vlasov
A P
AP
Grigor'eva
T I
TI
Leshchankina
N Iu
NIu
Nachkina
E I
EI
Timoshin
D S
DS
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004285:Dogs; D019446:Endotoxemia / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D054467:Phospholipases A2 / Q000378:metabolism
D000975:Antioxidants; D054467:Phospholipases A2