title: A new bioinformatics paradigm for the theory, research, and practice of therapeutic hypnosis.
abstract: In a 2008 pilot study we used DNA microarrays to explore the historical ideo-plastic faculty of therapeutic hypnosis. We documented how to measure changes in activity or experience-dependent gene expression over relatively brief time periods (1 hour and 24 hours) following a single intervention of therapeutic hypnosis (about 1 hour). In the present paper we utilize bioinformatic software to explore the possible meaning and significance of this ideo-plastic faculty of therapeutic hypnosis. Indications suggest that the ideo-plastic process of therapeutic hypnosis may be associated with (1) the heightening of a molecular-genomic signature for the up-regulation (heightened activity) of genes characteristic of stem cell growth, (2) a reduction in cellular oxidative stress, and (3) a reduction in chronic inflammation. We identify these three empirical associations as an initial beta version of the molecular-genomic signature of the ideo-plastic process of therapeutic hypnosis, which can serve as a theoretical and practical guide for clinical excellence by beginners as well as senior professionals. We propose this molecular-genomic level of discourse as a supplement to the traditional cognitive-behavioral description of therapeutic suggestion, hypnosis, and psychotherapy that is consistent with "translational research" currently funded by the National Institute of Mental Health (NIMH).
authors: University of Pittsburgh School of Medicine, USA.
authors: David
authors: D
authors: Atkinson
authors: Salvatore
authors: S
authors: Iannotti
authors: Mauro
authors: M
authors: Cozzolino
authors: Stefano
authors: S
authors: Castiglione
authors: Angela
authors: A
authors: Cicatelli
authors: Bhaskar
authors: B
authors: Vyas
authors: Jane
authors: J
authors: Mortimer
authors: Richard
authors: R
authors: Hill
authors: Erika
authors: E
authors: Chovanec
authors: Alessia
authors: A
authors: Chiamberlando
authors: Jorge
authors: J
authors: Cuadros
authors: Claude
authors: C
authors: Virot
authors: Michel
authors: M
authors: Kerouac
authors: Thierry
authors: T
authors: Kallfass
authors: Stanley
authors: S
authors: Krippner
authors: Claire
authors: C
authors: Frederick
authors: Bruce
authors: B
authors: Gregory
authors: Michael
authors: M
authors: Shaffran
authors: Margaret
authors: M
authors: Bullock
authors: Ella
authors: E
authors: Soleimany
authors: April Cybelle
authors: AC
authors: Rossi
authors: Kathryn
authors: K
authors: Rossi
authors: Ernest
authors: E
authors: Rossi
mesh_terms: D001921:Brain / Q000378:metabolism; D015928:Cognitive Behavioral Therapy; D019295:Computational Biology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000235:genetics*; D036281:Genetic Research; D006801:Humans; D006990:Hypnosis / Q000379:methods*; D007249:Inflammation / Q000235:genetics; D009473:Neuronal Plasticity / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D018384:Oxidative Stress; D012984:Software; D013234:Stem Cells / Q000502:physiology; D057170:Translational Research, Biomedical; D015854:Up-Regulation / Q000235:genetics