title: Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.
abstract: OBJECTIVE
  To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele.
  
  
  METHODS
  Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies.
  
  
  METHODS
  An international ovarian cancer consortium including studies from Australia, Europe, and the United States.
  
  
  METHODS
  Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies.
  
  
  METHODS
  None.
  
  
  METHODS
  Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis.
  
  
  RESULTS
  The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio=0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio=0.94, 95% confidence interval 0.76-1.16).
  
  
  CONCLUSIONS
  Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.
authors: Cancer Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
authors: Aimee M
authors: AM
authors: Near
authors: Anna H
authors: AH
authors: Wu
authors: Claire
authors: C
authors: Templeman
authors: David J
authors: DJ
authors: Van Den Berg
authors: Jennifer A
authors: JA
authors: Doherty
authors: Mary Anne
authors: MA
authors: Rossing
authors: Ellen L
authors: EL
authors: Goode
authors: Julie M
authors: JM
authors: Cunningham
authors: Robert A
authors: RA
authors: Vierkant
authors: Brooke L
authors: BL
authors: Fridley
authors: Georgia
authors: G
authors: Chenevix-Trench
authors: Penelope M
authors: PM
authors: Webb
authors: Susanne Krüger
authors: SK
authors: Kjær
authors: Estrid
authors: E
authors: Hogdall
authors: Simon A
authors: SA
authors: Gayther
authors: Susan J
authors: SJ
authors: Ramus
authors: Usha
authors: U
authors: Menon
authors: Aleksandra
authors: A
authors: Gentry-Maharaj
authors: Joellen M
authors: JM
authors: Schildkraut
authors: Patricia G
authors: PG
authors: Moorman
authors: Rachel T
authors: RT
authors: Palmieri
authors: Roberta B
authors: RB
authors: Ness
authors: Kirsten
authors: K
authors: Moysich
authors: Daniel W
authors: DW
authors: Cramer
authors: Kathryn L
authors: KL
authors: Terry
authors: Allison F
authors: AF
authors: Vitonis
authors: Malcolm C
authors: MC
authors: Pike
authors: Andrew
authors: A
authors: Berchuck
authors: Celeste Leigh
authors: CL
authors: Pearce
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D003299:Cooperative Behavior; D004715:Endometriosis / Q000453:epidemiology* / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D011980:Receptors, Progesterone; C101118:progesterone receptor A; C097314:progesterone receptor B