Chemical signal amplification in two-dimensional paper networks.
Two-dimensional paper networks (2DPNs) hold great potential for extending the utility of paper-based chemical and biochemical diagnostics at a cost and ease-of-use that is comparable to conventional lateral flow strips. 2DPNs enable the automated sequential delivery of multiple reagents to a detection region with a single user activation step, and therefore have the potential to extend the processing capabilities of inexpensive paper-based assays with comparable ease of use to conventional lateral flow tests. In this communication, we used a simple 3 inlet 2DPN to perform signal amplification of a colloidal gold label using a gold enhancement solution, thus demonstrating the capability of 2DPNs to perform processes that can improve limits of detection.
Fu
Elain
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Box 355061, Department of Bioengineering,,University of Washington, Seattle, WA, USA; Fax:206-616-3928; Tel: 206-685-9891.
Kauffman
Peter
P
Lutz
Barry
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Yager
Paul
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