title: MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells.
abstract: MicroRNA-10b (miR-10b) has been reported to facilitate the metastasis of breast cancer. However, little is known about the role of miR-10b in the metastasis of nasopharyngeal carcinoma (NPC). Here, we show that high levels of miR-10b expression in Epstein-Barr virus (EBV)-positive latent membrane protein-1 (LMP1)-expressing NPC cells, and its expression is down-regulated by silencing LMP1 or Twist. Induction of miR-10b over-expression in LMP1-silent C666-1 cells promoted significant wound healing and transmembrane invasiveness in vitro. More importantly, miR-10b over-expression promoted the metastasis of NPC and accelerated the death of tumor-bearing nude mice. These findings strongly suggest that miR-10b positively regulates the metastasis of NPC.
authors: Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors: Gang
authors: G
authors: Li
authors: Zhengrong
authors: Z
authors: Wu
authors: Ying
authors: Y
authors: Peng
authors: Xiong
authors: X
authors: Liu
authors: Juan
authors: J
authors: Lu
authors: Lu
authors: L
authors: Wang
authors: Qiuhui
authors: Q
authors: Pan
authors: Min-Liang
authors: ML
authors: He
authors: Xiang-Ping
authors: XP
authors: Li
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000821:virology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D051879:Twist-Related Protein 1 / Q000502:physiology; D014763:Viral Matrix Proteins / Q000032:analysis / Q000502:physiology*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; C547183:MIRN10 microRNA, human; D035683:MicroRNAs; D051879:Twist-Related Protein 1; D014763:Viral Matrix Proteins