[Efficiency and safety of recombinant activated factor VII in a case of severe postpartum hemorrhage].
We report the case of a severe postpartum hemorrhage (PPH) that was successfully treated with two administrations of recombinant activated factor VII (rFVIIa). Two major thromboembolic events (TEE) occurred shortly afterwards: the first was an acute lower limb ischemia at H3, the second was a cardiac arrest complicating a massive pulmonary embolism on day 5. Fortunately, both events had a favorable outcome. This case report allows us to discuss the role of rFVIIa during severe PPH and its potential responsibility in these two major TEE.
Geiger
A
A
Service d'anesthésie-réanimation, hôpital de Hautepierre, 1 avenue Molière, Strasbourg cedex, France.
Collange
O
O
Samin
J
J
Meyer
A
A
Freys
G
G
Pottecher
T
T
D000328:Adult; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012449:Safety; D012720:Severity of Illness Index
D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa