title: The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks.
abstract: Behavioral adaptation depends on the recognition of response errors and processing of this error-information. Error processing is a specific cognitive function crucial for behavioral adaptation. Neurophysiologically, these processes are reflected by an event-related potential (ERP), the error negativity (Ne/ERN). Even though synchronization processes are important in information processing, its role and neurobiological foundation in behavioral adaptation are not understood. The brain-derived neurotrophic factor (BDNF) strongly modulates the establishment of neural connectivity that determines neural network dynamics and synchronization properties. Therefore altered synchronization processes may constitute a mechanism via which BDNF affects processes of error-induced behavioral adaptation. We investigate how variants of the BDNF gene regulate EEG-synchronization processes underlying error processing. Subjects (n=65) were genotyped for the functional BDNF Val66Met polymorphism (rs6265). We show that Val/Val genotype is associated with stronger error-specific phase-locking, compared with Met allele carriers. Posterror behavioral adaptation seems to be strongly dependent on these phase-locking processes and efficacy of EEG-phase-locking-behavioral coupling was genotype dependent. After correct responses, neurophysiological processes were not modulated by the polymorphism, underlining that BDNF becomes especially necessary in situations requiring behavioral adaptation. The results suggest that alterations in neural synchronization processes modulated by the genetic variants of BDNF Val66Met may be the mechanism by which cognitive functions are affected.
authors: Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr-Universität Bochum, D-44780 Bochum, Germany. christian.beste@rub.de
authors: Christian
authors: C
authors: Beste
authors: Vasil
authors: V
authors: Kolev
authors: Juliana
authors: J
authors: Yordanova
authors: Katharina
authors: K
authors: Domschke
authors: Michael
authors: M
authors: Falkenstein
authors: Bernhard T
authors: BT
authors: Baune
authors: Carsten
authors: C
authors: Konrad
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics*; D009434:Neural Pathways / Q000502:physiology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D011930:Reaction Time / Q000502:physiology; D013057:Spectrum Analysis; D013997:Time Factors; D014633:Valine / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine