title: Research with rTMS in the treatment of aphasia.
abstract: This review of our research with rTMS to treat aphasia contains four parts: Part 1 reviews functional brain imaging studies related to recovery of language in aphasia with emphasis on nonfluent aphasia. Part 2 presents the rationale for using rTMS to treat nonfluent aphasia patients (based on results from functional imaging studies). Part 2 also reviews our current rTMS treatment protocol used with nonfluent aphasia patients, and our functional imaging results from overt naming fMRI scans, obtained pre- and post- a series of rTMS treatments. Part 3 presents results from a pilot study where rTMS treatments were followed immediately by constraint-induced language therapy (CILT). Part 4 reviews our diffusion tensor imaging (DTI) study that examined white matter connections between the horizontal, midportion of the arcuate fasciculus (hAF) to different parts within Broca's area (pars triangularis, PTr; pars opercularis, POp), and the ventral premotor cortex (vPMC) in the RH and in the LH. Part 4 also addresses some of the possible mechanisms involved with improved naming and speech, following rTMS with nonfluent aphasia patients.
authors: Veterans Affairs Boston Healthcare System and the Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, Boston, MA 02130, USA. mnaeser@bu.edu
authors: Margaret A
authors: MA
authors: Naeser
authors: Paula I
authors: PI
authors: Martin
authors: Ethan
authors: E
authors: Treglia
authors: Michael
authors: M
authors: Ho
authors: Elina
authors: E
authors: Kaplan
authors: Shahid
authors: S
authors: Bashir
authors: Roy
authors: R
authors: Hamilton
authors: H Branch
authors: HB
authors: Coslett
authors: Alvaro
authors: A
authors: Pascual-Leone
mesh_terms: D000818:Animals; D001037:Aphasia / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D001039:Aphasia, Broca / Q000523:psychology / Q000628:therapy; D038524:Diffusion Magnetic Resonance Imaging; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D007808:Language Therapy; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000473:pathology; D009483:Neuropsychological Tests; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome