A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives.
ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.
Gornall
Karina C
KC
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
Samosorn
Siritron
S
Tanwirat
Bongkot
B
Suksamrarn
Apichart
A
Bremner
John B
JB
Kelso
Michael J
MJ
Beck
Jennifer L
JL
D001599:Berberine / Q000031:analogs & derivatives*; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D017705:Lignans; D021241:Spectrometry, Mass, Electrospray Ionization
D017705:Lignans; D001599:Berberine; D004247:DNA