HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma.
HIV infection is associated with a much higher risk for the development of non-Hodgkin lymphoma (AIDS-NHL). The principal causes of lymphomagenesis in HIV-infected individuals are thought to be the loss of immune function seen in HIV infection, which results in the loss of immunoregulation of Epstein-Barr virus-infected B cells, as well as HIV infection-associated immune dysregulation, including chronic B-cell activation. In this review, we discuss recent reports that further support the importance of these factors, and we highlight emerging evidence of different mechanisms that potentially drive lymphomagenesis in HIV-infected individuals.
Epeldegui
Marta
M
Department of Microbiology, Immunology & Molecular Genetics, UCLA AIDS Institute, Los Angeles, CA, USA.
Vendrame
Elena
E
Martínez-Maza
Otoniel
O
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology*; D006678:HIV / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D016867:Immunocompromised Host; D017578:Immunoglobulin Class Switching; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D016483:Lymphoma, AIDS-Related / Q000209:etiology / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000276:immunology*