Desymmetrizing asymmetric ring expansion: stereoselective synthesis of 7-membered cyclic beta-keto carbonyl compounds with an alpha-hydrogen.
Ring expansion of symmetrically substituted cyclohexanones with N-alpha-diazoacetyl camphorsultam was devised as a stereoselective pathway to the functionalized 7-membered cyclic beta-keto carbonyls having a kinetically stabilized alpha-hydrogen.
Hashimoto
Takuya
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Naganawa
Yuki
Y
Maruoka
Keiji
K