TCF-1 flips the switch on Eomes.
The interaction between different transcriptional pathways in CD8(+) T cell memory remains incompletely understood. In this issue, Zhou et al. (2010) demonstrate an important role for T cell factor 1 in regulating CD8(+) T cell memory via control of a second transcription factor, Eomesodermin.
Paley
Michael A
MA
Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Wherry
E John
EJ