Discrimination ability of ASDAS estimating disease activity status in patients with ankylosing spondylitis.
OBJECTIVE
To investigate discrimination ability of the Assessment of Spondyloarthritis International Society (ASAS) endorsed disease activity score (ASDAS) versions evaluating low and high disease activity in an unselected group of patients with ankylosing spondylitis (AS).


METHODS
Patients consecutively included into the joint database of five university hospitals were analyzed for low or high disease activity according to different criteria. Standardized mean differences (SMD) for two ASDAS versions were evaluated.


RESULTS
The ASDAS versions (back pain, morning stiffness, patient global pain, pain/swelling of peripheral joints, plus either erythrocyte sedimentation rate or C-reactive protein) discriminated high and low disease activity in subgroups according to Bath Ankylosing Spondylitis Disease Activity Score (BASDAI) and ASAS remission/partial remission criteria. ASDAS versions were also not influenced by peripheral arthritis and correlated well with other outcome measurements and acute-phase reactants. The ASDAS versions performed better than patient-reported measures or acute-phase reactants discriminating high and low disease activity status.


CONCLUSIONS
Both ASDAS versions, consisting of both patient-reported data and acute-phase reactants, performed well in discriminating low and high disease activity. Further longitudinal data may better estimate the usefulness of ASDAS to assess disease activity subgroups and treatment response.
Nas
Kemal
K
Department of Physical Medicine and Rehabilitation (PMR), Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Yildirim
Kadir
K
Cevik
Remzi
R
Karatay
Saliha
S
Erdal
Akin
A
Baysal
Ozlem
O
Altay
Zuhal
Z
Kamanli
Ayhan
A
Ersoy
Yuksel
Y
Kaya
Arzu
A
Durmus
Bekir
B
Ardicoglu
Ozge
O
Tekeoglu
Ibrahim
I
Ugur
Mahir
M
Sarac
Aysegul Jale
AJ
Senel
Kazim
K
Gur
Ali
A
Ozgocmen
Salih
S
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D019992:Databases as Topic; D016002:Discriminant Analysis; D005260:Female; D006305:Health Status Indicators; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011788:Quality of Life; D057566:Self Report; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014421:Turkey
D015415:Biomarkers; D002097:C-Reactive Protein