title: Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection.
abstract: Mice carrying a defective leptin receptor gene (db/db mice) are metabolically challenged and upon infection with Trypanosoma cruzi (Brazil strain) suffer high mortality. In genetically modified db/db mice, (NSE-Rb db/db mice), central leptin signaling is reconstituted only in the brain, which is sufficient to correct the metabolic defects. NSE-Rb db/db mice were infected with T. cruzi to determine the impact of the lack of leptin signaling on infection in the absence of metabolic dysregulation. Parasitemia levels, mortality rates, and tissue parasitism were statistically significantly increased in infected db/db mice compared with those in infected NSE-Rb db/db and FVB wild-type mice. There was a reduction in fat mass and blood glucose level in infected db/db mice. Plasma levels of several cytokines and chemokines were statistically significantly increased in infected db/db mice compared with those in infected FVB and NSE-Rb db/db mice. These findings suggest that leptin resistance in individuals with obesity and diabetes mellitus may have adverse consequences in T. cruzi infection.
authors: Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
authors: Fnu
authors: F
authors: Nagajyothi
authors: Dazhi
authors: D
authors: Zhao
authors: Fabiana S
authors: FS
authors: Machado
authors: Louis M
authors: LM
authors: Weiss
authors: Gary J
authors: GJ
authors: Schwartz
authors: Mahalia S
authors: MS
authors: Desruisseaux
authors: Yang
authors: Y
authors: Zhao
authors: Stephen M
authors: SM
authors: Factor
authors: Huan
authors: H
authors: Huang
authors: Chris
authors: C
authors: Albanese
authors: Mauro M
authors: MM
authors: Teixeira
authors: Philipp E
authors: PE
authors: Scherer
authors: Streamson C
authors: SC
authors: Chua
authors: Herbert B
authors: HB
authors: Tanowitz
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D014355:Chagas Disease / Q000401:mortality / Q000469:parasitology* / Q000473:pathology*; D016207:Cytokines / Q000097:blood; D051379:Mice; D018512:Parasitemia; D054411:Receptors, Leptin / Q000172:deficiency / Q000502:physiology*; D016019:Survival Analysis; D014349:Trypanosoma cruzi / Q000472:pathogenicity*
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D054411:Receptors, Leptin; C515447:leptin receptor, mouse