title: Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction.
abstract: The hypothalamus plays an important role in maintaining a homeostasis of the body against stress response. In particular, the paraventricular nucleus of the hypothalamus is a critical region for disorders related to the autonomic nervous system, such as congestive heart failure and hypertension. αB-crystallin is a family of heat shock proteins that are widely expressed in the brain, including in glial cells, astrocytes, oligodendrocytes, and neurons. Many studies have demonstrated that expression level of αB-crystallin is up-regulated and involved in protecting cells from pathological conditions. In the present study, we examined the expression and potential role of αB-crystallin in the paraventricular nucleus (PVN) regions of rats with myocardial infarction (MI). Our results demonstrate that mRNA encoding αB-crystallin and protein for both native and phosphorylate forms (Ser-59) of αB-crystallin was significantly increased in the PVN during MI.
authors: Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
authors: Soo Hwa
authors: SH
authors: Jang
authors: Tae Hee
authors: TH
authors: Han
authors: In Koo
authors: IK
authors: Hwang
authors: Seon Ah
authors: SA
authors: Park
authors: Yong Geun
authors: YG
authors: Kwak
authors: Jin Bong
authors: JB
authors: Park
authors: Seong Kyu
authors: SK
authors: Han
authors: Pan Dong
authors: PD
authors: Ryu
authors: So Yeong
authors: SY
authors: Lee
mesh_terms: D000818:Animals; D003459:Crystallins / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D009203:Myocardial Infarction / Q000473:pathology*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D012333:RNA, Messenger; D051381:Rats; D017207:Rats, Sprague-Dawley; D012694:Serine / Q000378:metabolism
chemical_list: D003459:Crystallins; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger; C530883:cryaB protein, rat; D012694:Serine