title: Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines.
abstract: We have focused on the C5-modification of 2'-deoxyuridine with substituted heterocycles for bioactivity, such as antiviral or anticancer activity. Herein, we report a novel class of nucleoside analogues with perfluoroalkyltriazole moiety as an anticancer drug candidate.
authors: Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
authors: Sun Min
authors: SM
authors: Park
authors: Heeju
authors: H
authors: Yang
authors: Song-Kyu
authors: SK
authors: Park
authors: Hwan Mook
authors: HM
authors: Kim
authors: Byeang Hyean
authors: BH
authors: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003857:Deoxyuridine / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D014230:Triazoles; D005461:Fluorine; D003857:Deoxyuridine