Monoterpenoid indole alkaloids mediating DNA strand scission from Turpinia arguta.
Two new monoterpenoid indole alkaloid derivatives, turpiniside (1) and 11-methoxyjavaniside (2), along with the known alkaloids, vincosamide (3), (3 R)-pumiloside (4), and paratunamide C (5), were isolated from the leaves of Turpinia arguta (Lindl.) Seem. Their structures were determined on the basis of spectroscopic data. Compounds 1 and 3-5 were found to effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu²+.
Wu
Min
M
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, P. R. China.
Wu
Ping
P
Xie
Haihui
H
Wu
Guojiang
G
Wei
Xiaoyi
X
D003300:Copper; D004247:DNA / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010957:Plasmids / Q000187:drug effects*; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C561250:11-methoxyjavaniside; D006027:Glycosides; D010936:Plant Extracts; D046948:Secologanin Tryptamine Alkaloids; C561249:turpiniside; D003300:Copper; D004247:DNA