title: [Dosimetric stereotactic radiosurgical accident: Study of 33 patients treated for brain metastases].
abstract: The consequences of a dosimetric radiosurgery accident are not the same as a conventional radiotherapy accident. The objective of this study was to estimate the clinical and radiological outcome of patients treated by radiosurgery for metastasis during the period of the overexposure accident that occurred in the Toulouse Radiosurgery Unit. Between April 2006 and March 2007, 33 patients with 57 metastases were treated in the Toulouse Radiosurgery Unit (Novalis(®), BrainLab). An initial error in the estimation of the scatter factors led to an overexposure to radiation. The median age was 55 years [range, 35-85]. Twenty-one patients (64%) harbored a single metastasis. The primary tumor location was lung (16 cases), kidney (nine cases), breast (four cases), and others (four cases). The mean tumoral volume was 3.2cm(3) [0.04-14.07]. The mean prescribed dose at the isocenter was 20 Gy [range, 10-23], the mean delivered dose was 31.5 Gy [range, 13-52], and the mean overdose was 61.2% [range, 5.6-226.8]. In order to evaluate the consequences of the overdose, three parameters were analyzed: a risk index using dose and volume, the volume of parenchyma that received more than 12 Gy, and the mean dose in a sphere of 20cm(3) surrounding the target volume. Median actuarial survival was 14.1 months, the survival rate was 79.4 % at six months, 59.1% at 12 months, and 27.2% at 24 months. The rate of tumor control was 80.7%. No morbidity was observed. There was no correlation between death and the parameters studied. The survival rates and times observed in our study of the patients treated for brain metastases by radiosurgery and overexposed were among the good results of the international literature. Deaths were not related to the overdose and no side effect was noted. This dosimetric accident has not had worse consequences in this population.
authors: Centre régional de radiochirurgie stéréotaxique, centre hospitalier universitaire de Toulouse, hôpital Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex 9, France. pierre-yves.borius@hotmail.fr
authors: P-Y
authors: PY
authors: Borius
authors: B
authors: B
authors: Debono
authors: I
authors: I
authors: Latorzeff
authors: J-A
authors: JA
authors: Lotterie
authors: J-Y
authors: JY
authors: Plas
authors: E
authors: E
authors: Cassol
authors: P
authors: P
authors: Bousquet
authors: F
authors: F
authors: Loubes
authors: P
authors: P
authors: Duthil
authors: A
authors: A
authors: Durand
authors: F
authors: F
authors: Caire
authors: A
authors: A
authors: Redon
authors: I
authors: I
authors: Berry
authors: J
authors: J
authors: Sabatier
authors: Y
authors: Y
authors: Lazorthes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016634:Radiosurgery / Q000009:adverse effects*; D011879:Radiotherapy Dosage