title: The microRNA pathway and cancer.
abstract: MicroRNAs (miRNAs) are ∼22nt long, non-coding RNAs that guide post-transcriptional gene silencing of their target genes and regulate diverse biological processes including cancer. miRNAs do not act alone, but require assembly into RNA-induced silencing complex (RISC). In this review, we summarize how miRNAs are produced, assembled into RISC, and regulate target mRNAs, and discuss how the miRNA pathway is involved in cancer.
authors: Institute of Molecular and Cellular Biosciences Department of Medical Genome Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Pieter Bas
authors: PB
authors: Kwak
authors: Shintaro
authors: S
authors: Iwasaki
authors: Yukihide
authors: Y
authors: Tomari
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D034743:RNA-Induced Silencing Complex