Cell-matrix adhesion: slip and immobilization under force.
When force is applied to cell-matrix adhesion complexes, they respond by growing larger and stronger. It emerges that strengthening involves transient motion of the transmembrane integrin receptors and their eventual immobilization to the extracellular matrix.
Verkhovsky
Alexander B
AB
Ecole Polytechnique Fédérale de Lausanne, Laboratory of Cell Biophysics, Lausanne, 1015, Switzerland. alexander.verkhovsky@epfl.ch
D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D005109:Extracellular Matrix / Q000502:physiology*; D022001:Focal Adhesions; D006801:Humans; D016023:Integrins / Q000502:physiology; D024462:Myosin Type II / Q000502:physiology
D016023:Integrins; D024462:Myosin Type II