Quetiapine-associated cholestasis causing lipoprotein-X and pseudohyponatraemia.
A case of intrahepatic cholestasis secondary to treatment with quetiapine in combination with lamotrigine and zopiclone, resulting in severe hypercholesterolaemia without overt lactescence of the plasma, is presented. Abundant lipoprotein-X was seen on lipoprotein electrophoresis. The patient was diagnosed and treated for hyponatraemia which was likely factitious and caused by hypercholesterolaemia. Cholestasis and hypercholesterolaemia resolved over a period of several months after the discontinuation of quetiapine.
Klinke
J A
JA
Department of Medicine, Royal Columbian Hospital, New Westminster, British Columbia, Canada.
Shapira
S C
SC
Akbari
E
E
Holmes
D T
DT
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D003987:Dibenzothiazepines / Q000009:adverse effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced; D007010:Hyponatremia / Q000139:chemically induced*; D008073:Lipoprotein-X / Q000097:blood*; D008297:Male; D000069348:Quetiapine Fumarate
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D008073:Lipoprotein-X; D000069348:Quetiapine Fumarate