title: Standardized protocols for plasma clearance of iohexol are not appropriate for determination of glomerular filtration rates in anesthetized California sea lions (Zalophus californianus).
abstract: Abstract: Plasma clearance of iohexol was evaluated in eight anesthetized California sea lions (Zalophus californianus), without evidence of renal dysfunction, to determine if the one-compartment model and the sample protocol used in dogs and cats could be applied to this species. Nonlinearity between samples in 75% (6/8) of sea lions voided those results. An additional two anesthetized sea lions were sampled at 5, 30, 45, 60, 120, 180, 240, and 360 min post iohexol injection and semi-logarithmic curves calculated. Plasma iohexol clearance values calculated by one-, two-, and noncompartment models were in poor agreement, suggesting that the standardized protocol described for dogs and cats cannot simply be applied to California sea lions, probably due to the effects of the dive reflex induced during anesthesia.
authors: The Marine Mammal Center, 1065 Fort Cronkhite, Sausalito, California 94965, USA. vetradiologist@hotmail.com
authors: Sophie E
authors: SE
authors: Dennison
authors: Frances M D
authors: FM
authors: Gulland
authors: W Emmett
authors: WE
authors: Braselton
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology / Q000662:veterinary*; D007472:Iohexol / Q000493:pharmacokinetics*; D046070:Sea Lions / Q000502:physiology*
chemical_list: D003287:Contrast Media; D007472:Iohexol