title: Relation of MT1-MMP gene expression to outcomes in colorectal cancer.
abstract: BACKGROUND
  Matrix metalloproteinases are members of a large family of endopeptidases that participate in the extracellular-matrix degradation that accompanies cancer cell invasion, metastasis and angiogenesis. The membrane-type 1 matrix metalloproteinase (MT1-MMP) gene has been reported in various cancers and is associated with tumor invasion and metastasis. This study examined the relation of the relative expression of MT1-MMP gene to clinicopathological factors and outcomes in patients with colorectal cancer (CRC).
  
  
  METHODS
  We studied surgical specimens of cancer tissue and adjacent normal mucosa obtained from 202 patients with untreated CRC. The relative expression levels of MT1-MMP mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction.
  
  
  RESULTS
  MT1-MMP gene expression was higher in cancer tissue than in adjacent normal mucosa. The level of MT1-MMP gene expression was not related to any clinicopathological factor. Overall survival at 5 years differed significantly between patients with high MT1-MMP gene expression and those with low expression.
  
  
  CONCLUSIONS
  Overexpression of the MT1-MMP gene is considered a useful independent predictor of outcomes in patients with CRC.
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa-ken, Japan. amanex2009@gmail.com
authors: Amane
authors: A
authors: Kanazawa
authors: Takashi
authors: T
authors: Oshima
authors: Kazue
authors: K
authors: Yoshihara
authors: Shuzo
authors: S
authors: Tamura
authors: Takanobu
authors: T
authors: Yamada
authors: Daisuke
authors: D
authors: Inagaki
authors: Tsutomu
authors: T
authors: Sato
authors: Naoto
authors: N
authors: Yamamoto
authors: Manabu
authors: M
authors: Shiozawa
authors: Soichiro
authors: S
authors: Morinaga
authors: Makoto
authors: M
authors: Akaike
authors: Chikara
authors: C
authors: Kunisaki
authors: Katsuaki
authors: K
authors: Tanaka
authors: Munetaka
authors: M
authors: Masuda
authors: Toshio
authors: T
authors: Imada
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D012333:RNA, Messenger; D053511:Matrix Metalloproteinase 14