Role of serum adiponectin level in the development of liver cirrhosis in patients with hepatitis C virus.
Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis-C-related liver disease. The aim of our study was to find a relationship between serum adiponectin levels and different grades of steatohepatitis in HCV-infected patients and to correlate it with the severity of liver disease. Sixty HCV-infected patients were divided into two groups according to the presence/absence of steatosis proofed by abdominal ultrasonography and liver biopsy was selected. We evaluated the biochemical parameters for all patients including: ALT, AST, total bilirubin, direct bilirubin, alkaline phosphatase, serum albumin, prothrombin time, CBC, lipid profile, fasting blood glucose, fasting insulin, and serum adiponectin; HOMA-IR was calculated as [fasting insulin (mIU/l) × fasting glucose (mmol/l)]/22.5. We found that adiponectin was significantly lower in HCV-infected patients with steatosis than in those without steatosis. BMI, fasting blood glucose and HOMA-IR were significantly higher in HCV-infected patients with steatosis than in those without steatosis. Furthermore, it was found that steatosis correlates directly with fibrosis index, BMI, HOMA-IR, fasting blood glucose and ALT. Serum adiponectin levels inversely correlates with the grade of steatosis, histological activity index and the stage of fibrosis.
Latif
Hatem Abdel
HA
The Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Assal
Heba S
HS
Mahmoud
Mohamed
M
Rasheed
Wafaa I
WI
D000005:Abdomen / Q000000981:diagnostic imaging; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry; D012720:Severity of Illness Index; D014463:Ultrasonography
C499918:ADIPOQ protein, human; D052242:Adiponectin