Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe.
We report a case of suggestive synchronous triple squamous cell carcinoma (Sq) of the lung that occurred in the same lobe. Under a clinical diagnosis of triple lung cancer, lobectomy was performed. Pathological examination revealed two well-differentiated Sq and one poorly differentiated Sq. The analysis of epidermal growth factor receptor-tyrosine kinase mutations showed no mutation in each tumor. However, pathological findings and the positive rate of immunochemical reaction of p53 and Ki-67 were different in each tumor.
Okita
Riki
R
Department of General Thoracic Surgery, Hiroshima University Hospital, Hiroshima, Japan. riki0716okita@yahoo.co.jp
Shimizu
Katsuhiko
K
Mimura
Takeshi
T
Miyata
Yoshihiro
Y
Okada
Morihito
M
Arihiro
Koji
K
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D009154:Mutation; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011013:Pneumonectomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C512478:EGFR protein, human; D066246:ErbB Receptors