Inflammatory pathways in endometrial disorders.
Complex interactions between the endocrine and immune systems govern the key endometrial events of implantation and menstruation. In contrast to other tissue sites, cyclical endometrial inflammation is physiological. However, dysregulation of this inflammatory response can lead to endometrial disorders. This review examines the inflammatory processes occurring in the normal endometrium during menstruation and implantation, highlighting recent advances in our understanding and gaps in current knowledge. Subsequently, the role of inflammatory pathways in the pathology of various common endometrial conditions is discussed, including heavy menstrual bleeding, dysmenorrhoea (painful periods), uterine fibroids, endometriosis and recurrent miscarriage.
Maybin
Jacqueline A
JA
University of Edinburgh Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
Critchley
Hilary O D
HO
Jabbour
Henry N
HN
D000026:Abortion, Habitual / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D003656:Decidua / Q000378:metabolism; D004412:Dysmenorrhea / Q000276:immunology / Q000503:physiopathology; D010064:Embryo Implantation / Q000502:physiology; D004715:Endometriosis / Q000276:immunology / Q000503:physiopathology; D004717:Endometrium / Q000276:immunology* / Q000502:physiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007889:Leiomyoma / Q000276:immunology / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology; D008598:Menstruation / Q000502:physiology; D011247:Pregnancy