title: The relationship between insulin resistance and hypercoagulability in acute ischemic stroke.
abstract: OBJECTIVE
  Insulin resistance has effects on the coagulation system, which is important in the acute phase of infarct. We examined the relationships between insulin resistance, hemostatic markers and stroke severity in acute ischemic stroke patients.
  
  
  METHODS
  Protein C (PC), protein S (PS), fibrinogen, von Willebrand factor and antithrombin III (AT III) were studied in 75 acute ischemic stroke patients with and without insulin resistance.
  
  
  RESULTS
  The PC and PS levels of insulin-resistant patients were significantly lower than those of non-insulin-resistant patients (PC: 87 ± 19.23 vs. 97.89 ± 13.3%, p = 0.007; PS: 84.75 ± 15.72 vs. 93.21 ± 15.02%, p = 0.02), and both of the anticoagulants were correlated with the homeostasis model assessment (HOMA; r = -0.339, p = 0.003 and r = -0.481, p = 0.000, respectively). Additionally, the NIH Stroke Scale (NIHSS) score correlated negatively with PS (r = -0.329, p = 0.004) and AT III levels (r = -0.235, p = 0.04). The parameters with positive correlations with NIHSS were fibrinogen (r = 0.270, p = 0.019), fasting glucose (r = 0.358, p = 0.008) and HOMA (r = 0.286, p = 0.013).
  
  
  CONCLUSIONS
  The significant associations between insulin resistance and hemostatic markers may be relevant to stroke severity by causing a procoagulant tendency in acute ischemic stroke.
authors: Department of Neurology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey. ozkulayca@hotmail.com
authors: Ayca
authors: A
authors: Ozkul
authors: Eylem Telli
authors: ET
authors: Turgut
authors: Ali
authors: A
authors: Akyol
authors: Cigdem
authors: C
authors: Yenisey
authors: Gurhan
authors: G
authors: Kadikoylu
authors: Cengiz
authors: C
authors: Tataroglu
authors: Nefati
authors: N
authors: Kiylioglu
mesh_terms: D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D012720:Severity of Illness Index; D013223:Statistics as Topic; D020521:Stroke / Q000150:complications* / Q000378:metabolism; D019851:Thrombophilia / Q000209:etiology* / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D011486:Protein C; D017293:Protein S; D014841:von Willebrand Factor; D005340:Fibrinogen