Cystatin C as a parameter of glomerular filtration rate in patients with ovarian cancer.
OBJECTIVE
To evaluate the potential role of serum cystatin C as a marker of renal function in patients with ovarian cancer.


METHODS
Treatment of consecutive ovarian cancer patients who were eligible for chemotherapy with paclitaxel (135 mg/m²/24 h) and cisplatin (75 mg/m²) every 3 weeks in 6 cycles. Glomerular filtration rate (GFR) markers, i.e. serum levels of creatinine and cystatin C, estimated by the Cockcroft-Gault and Modification of Diet in Renal Disease formulas, were recorded before each cycle and 3 weeks after the 6th course.


RESULTS
The median age of 34 patients was 54 years. In the initial stage of treatment, we did not observe any correlation between cystatin C and other GFR markers. We noted a significant association between cystatin C and tumor extent on spiral CT scans (diameter: >1 cm) performed at baseline (p = 0.004), and after the 1st (p = 0.03) and 2nd cycle (p = 0.026). We observed a correlation between cystatin C and CA-125 level before chemotherapy (R = 0.4; p = 0.02) and after the 1st cycle (R = 0.43; p = 0.04).


CONCLUSIONS
The results of our study suggest that cystatin C is not a reliable marker of the GFR in ovarian cancer patients, probably due to its nature as a cysteine protease inhibitor.
Bodnar
Lubomir
L
Department of Oncology, Military Institute of Medicine, Warsaw, Poland. lubo@esculap.pl
Wcislo
Gabriel Benedykt
GB
Smoter
Marta
M
Gasowska-Bodnar
Agnieszka
A
Stec
Rafał
R
Synowiec
Agnieszka
A
Szczylik
Cezary
C
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D055316:Cystatin C / Q000032:analysis*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D047368:Tumor Burden
D055316:Cystatin C