title: Risk factors for medication non-adherence in an HIV infected population in the Dominican Republic.
abstract: High levels of medication adherence are central to HIV treatment success. Barriers to medication adherence may differ by cultural setting. We aimed to determine risk factors for medication non-adherence in HIV infected individuals in the Dominican Republic. Adherence was measured in 300 individuals using a visual analog scale assessing the prior month and dichotomized at 95%. High levels of adherence were reported by 228 (76%). Risk factors for non-adherence included heavy alcohol use: 2.5 times odds (95% CI: 1.4-4.5), having children: 2.2 times higher odds (95% CI: 1.1-4.9) and perceptions of less social support related to adherence: 2 times higher odds (95% CI: 1.1-3.6). Culturally appropriate interventions are needed to address alcohol use, which is common in this setting. Parenting may represent a competing demand on time and resources and be an adherence barrier. Self-reported perceived lack of adherence support may be a useful marker for need for adherence interventions.
authors: Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Julian
authors: J
authors: Harris
authors: Mara
authors: M
authors: Pillinger
authors: Deborah
authors: D
authors: Fromstein
authors: Bayardo
authors: B
authors: Gomez
authors: Ivelisse
authors: I
authors: Garris
authors: Peter A
authors: PA
authors: Kanetsky
authors: Pablo
authors: P
authors: Tebas
authors: Robert
authors: R
authors: Gross
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004293:Dominican Republic; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D012307:Risk Factors; D012944:Social Support; D019966:Substance-Related Disorders / Q000150:complications; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents