title: Pyoderma gangrenosum of the eyelid: report of two cases and review of the literature.
abstract: Pyoderma gangrenosum (PG) of the eyelid is extremely rare, and its proper management is essential for the preservation of visual function. Here, we report 2 cases of PG of the eyelid with intraorbital involvement. In both cases, the skin and intraorbital lesions improved after systemic immunosuppressive therapies; however, corneal perforation occurred in 1 case. In order to assess the clinical features of PG of the eyelid and to obtain clues for optimal treatment, we reviewed 15 well-documented cases in the literature, including the present cases. Corneal perforation occurred in 4 cases and defective ocular motility in 1 case. Three patients eventually underwent enucleation of the affected eye. Our cases and the literature review clearly indicate that MRI is a powerful tool for evaluating the extent of extracutaneous PG lesions around the eye and that early diagnosis and immediate immunosuppressive therapy are crucial for the preservation of visual acuity.
authors: Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. bird09160078@yahoo.co.jp
authors: N
authors: N
authors: Saito
authors: T
authors: T
authors: Yanagi
authors: M
authors: M
authors: Akiyama
authors: H Y
authors: HY
authors: Lin
authors: S
authors: S
authors: Kasai
authors: Y
authors: Y
authors: Fujita
authors: N
authors: N
authors: Yamane
authors: D
authors: D
authors: Inokuma
authors: S
authors: S
authors: Kase
authors: K
authors: K
authors: Ono
authors: H
authors: H
authors: Minakawa
authors: H
authors: H
authors: Shimizu
mesh_terms: D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005141:Eyelid Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone