title: Gastrointestinal stromal tumors (GISTs): an updated experience.
abstract: BACKGROUND
  Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors of the digestive tract characterized by c-KIT mutations. This is a comprehensive review of the current data of the literature on the various aspects of the diagnosis and treatment of these tumors.
  
  
  METHODS
  The stomach is the most commonly involved site for these tumors in the digestive tract. Computed tomography and endoscopy can usually establish the diagnosis. The study of certain specific immunohistochemical markers may contribute to better characterization of these tumors.
  
  
  RESULTS
  Surgical resection of GISTs has been the most effective therapy. In addition, targeted therapy with tyrosine kinase inhibitors may reduce the development of recurrence or decrease the disease progression in patients with metastatic disease.
  
  
  CONCLUSIONS
  The introduction of tyrosine kinase inhibitors has resulted in significant improvement in the overall prognosis of these patients. Furthermore, preoperative imatinib can decrease tumor volume and is associated with complete surgical resection in locally advanced primary GISTs.
authors: 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, 1 Rimini Street, Chaidari-Athens 12462, Greece.
authors: Anastasios
authors: A
authors: Machairas
authors: Eva
authors: E
authors: Karamitopoulou
authors: Dimitrios
authors: D
authors: Tsapralis
authors: Theodore
authors: T
authors: Karatzas
authors: Nickolas
authors: N
authors: Machairas
authors: Evangelos P
authors: EP
authors: Misiakos
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D014408:Biomarkers, Tumor; D003937:Diagnosis, Differential; D018450:Disease Progression; D016099:Endoscopy, Gastrointestinal; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010879:Piperazines / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000187:drug effects / Q000502:physiology; D011743:Pyrimidines / Q000627:therapeutic use; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha