title: A flow microreactor system enables organolithium reactions without protecting alkoxycarbonyl groups.
abstract: A flow microreactor system consisting of micromixers and microtube reactors provides an effective tool for the generation and reactions of aryllithiums bearing an alkoxycarbonyl group at para-, meta-, and ortho-positions. Alkyl p- and m-lithiobenzoates were generated by the I/Li exchange reaction with PhLi. The Br/Li exchange reactions with sBuLi were unsuccessful. Subsequent reactions of the resulting aryllithiums with electrophiles gave the desired products in good yields. On the other hand, alkyl o-lithiobenzoates were successfully generated by the Br/Li exchange reaction with sBuLi. Subsequent reactions with electrophiles gave the desired products in good yields.
authors: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan.
authors: Aiichiro
authors: A
authors: Nagaki
authors: Heejin
authors: H
authors: Kim
authors: Yuya
authors: Y
authors: Moriwaki
authors: Chika
authors: C
authors: Matsuo
authors: Jun-ichi
authors: J
authors: Yoshida