title: Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit.
abstract: BACKGROUND
  Current evidence suggests that umbilical arterial pH analysis provides the most sensitive reflection of birth asphyxia. However, there's debate whether umbilical cord blood gas analysis (UC-BGA) should be conducted on some or all deliveries.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the impact of introducing universal UC-BGA at delivery on perinatal outcome.
  
  
  METHODS
  An observational study of all deliveries > or =20 weeks' gestation at a tertiary obstetric unit between January 2003 and December 2006. Paired UC-BGA was performed on 97% of deliveries (n = 19,646). Univariate and adjusted analysis assessed inter-year UC-BGA differences and the likelihood of metabolic acidosis and nursery admission.
  
  
  RESULTS
  There was a progressive improvement in umbilical artery pH, pO(2), pCO(2), base excess and lactate values in univariate and adjusted analyses (P < 0.001). There was a significant reduction in the newborns with an arterial pH <7.10 (OR = 0.71; 95%CI 0.53-0.95) and lactate >6.1 mmol/L (OR = 0.37; 95%CI 0.30-0.46). Utilising population specific 5th and 95th percentiles, there was a reduction in newborns with arterial pH less than 5th percentile (pH 7.12; OR = 0.75; 95%CI 0.59-0.96) and lactate levels greater than 95th percentile (6.7 mmol/L; OR = 0.37; 95%CI 0.29-0.49). There was a reduction in term (OR = 0.65; 95%CI 0.54-0.78), and overall (OR = 0.75; 95%CI 0.64-0.87) nursery admissions. These improved perinatal outcomes were independent of intervention rates.
  
  
  CONCLUSIONS
  These data suggest that introduction of universal UC-BGA may result in improved perinatal outcomes, which were observed to be independent of obstetric intervention. We suggest that these improvements might be attributed to provision of biochemical data relating to fetal acid-base status at delivery influencing intrapartum care in subsequent cases.
authors: The University of Western Australia, Perth, Australia. whitec06@student.uwa.edu.au
authors: Christopher R H
authors: CR
authors: White
authors: Dorota A
authors: DA
authors: Doherty
authors: Jennifer J
authors: JJ
authors: Henderson
authors: Rolland
authors: R
authors: Kohan
authors: John P
authors: JP
authors: Newnham
authors: Craig E
authors: CE
authors: Pennell
mesh_terms: D000138:Acidosis; D000328:Adult; D001238:Asphyxia Neonatorum / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D001784:Blood Gas Analysis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007773:Lactates / Q000097:blood*; D016015:Logistic Models; D009775:Obstetrics and Gynecology Department, Hospital; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D011256:Pregnancy Outcome / Q000453:epidemiology; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D007773:Lactates