title: MTRR polymorphism and the risk for colorectal and breast cancer in Romanian patients--a preliminary study.
abstract: BACKGROUND
  The risk of colorectal cancer (CRC) and breast cancer (BC) is influenced by polymorphisms located in the genes encoding enzymes of the folate pathway. The aim of this study was to evaluate if A66G MTRR (rs1801394) polymorphism is involved in predisposition for colorectal and breast carcinogenesis in Romanian patients.
  
  
  METHODS
  In the present case-control study, 300 individuals divide in four groups: sporadic CRC patients (n = 120), control CRC (n = 60), BC patients (n = 60) and control BC (n = 60), were genotyped by PCR-RFLP method.
  
  
  RESULTS
  Frequency of genotype AA was 11.7% in CRC control and 5% respectively in BC control. For cancer groups the frequency of genotype AA was 9.2% in CRC and 0% in BC.
  
  
  CONCLUSIONS
  Study results do not demonstrate an association between A66G MTRR polymorphism and CRC or BC in Romanian patients.
authors: Surgical Departament, Colţea Hospital, Bucharest, Romania.
authors: T
authors: T
authors: Burcoş
authors: M
authors: M
authors: Toma
authors: M
authors: M
authors: Stavarachi
authors: D
authors: D
authors: Cimponeriu
authors: P
authors: P
authors: Apostol
authors: E
authors: E
authors: Popa
authors: S
authors: S
authors: Stăñilescu
authors: I
authors: I
authors: Popa
authors: I
authors: I
authors: Radu
authors: C
authors: C
authors: Serafinceanu
authors: N
authors: N
authors: Panduru
authors: L
authors: L
authors: Beluşică
authors: L
authors: L
authors: Gavrilă
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018570:Risk Assessment; D012307:Risk Factors; D012383:Romania
chemical_list: C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase