Alloreactive natural killer cells in hematopoietic stem cell transplantation.
Allogeneic hematopoietic stem cell transplantation (HSCT) for leukemia can play a major role in reducing the risk of relapse by inducing a graft versus leukemia (GVL) effect. Here, we review the effectiveness of mismatching inhibitory killer-cell-immunoglobulin-like receptors (KIR) on donor natural killer (NK) cells as a mechanism for GVL. We review the range of KIR and the importance of T cell and NK cell content of the graft, together with considerations of the graft source. Further understanding of conditioning and mechanisms to reduce graft versus host disease (GVHD) will improve our ability to manipulate NK cells in HSCT.
Pegram
Hollie J
HJ
Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Ritchie
David S
DS
Smyth
Mark J
MJ
Wiernik
Andres
A
Prince
H Miles
HM
Darcy
Phillip K
PK
Kershaw
Michael H
MH
D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D054340:Receptors, KIR / Q000276:immunology
D054340:Receptors, KIR