Mitochondria and aging in the vascular system.
This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants.
Ungvari
Zoltan
Z
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK 73104, USA. zoltan-ungvari@ouhsc.edu
Sonntag
William E
WE
Csiszar
Anna
A
D000375:Aging / Q000502:physiology*; D001808:Blood Vessels / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism
D017382:Reactive Oxygen Species