title: Synthesis and Reactivity Studies of α,α-Difluoromethylphosphinates.
abstract: The preparation and reactivity of some α,α-difluorophosphinates is investigated. Alkylation of H-phosphinates with LiHMDS and ClCF(2)H gives the corresponding α,α-difluorophosphinates in good yield. Deprotonation of these reagents with alkyllithium or LDA is then studied. Subtle electronic effects translate into significant differences in the deprotonation/alkylation of the two "Ciba-Geigy reagents" (EtO)(2)CRP(O)(OEt)H (R = H, Me). On the other hand, attempted methylation of difluoromethyl-octyl-phosphinic acid butyl ester resulted in the exclusive alkylation of the octyl chain. Finally, reaction with carbonyl compounds results in the formation of 1,1-difluoro-2-phosphinoyl compounds.
authors: Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, U.S.A.
authors: Isabelle
authors: I
authors: Abrunhosa-Thomas
authors: Laëtitia
authors: L
authors: Coudray
authors: Jean-Luc
authors: JL
authors: Montchamp