Microsatellite instability in endometrial polyps.
OBJECTIVE
To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability.


METHODS
Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25, BAT26, D2S123, D5S346 and D17S250. Histopathological analysis was performed, and clinical information was obtained from patients' records.


RESULTS
MSI low was detected in 6.4% of the validated samples (7/109). Of the seven MSI that were detected, six were positive for instability at D17S250 and one at D5S346. There were no significant differences between polyps with or without MSI with regard to age, BMI, menarche, parity, miscarriage or menopause; however, MSI was more frequent in polyps with simple hyperplasia without atypia (3/20; 15%). Furthermore, patients with multiple polyps had a marginally but statistically insignificant increase in the frequency of MSI (p<0.07).


CONCLUSIONS
This is the first prospective study of MSI in endometrial polyps using hysteroscopically obtained samples. In a population of 109 patients, MSI was infrequent in endometrial polyps. Although MSI appears to be more frequent in multiple polyps and polyps with simple hyperplasia without atypia, this was not statistically significant.
Rios
Salete S
SS
Molecular Pathology Post-graduated Program, University of Brasilia, Brasilia, DF, Brazil. saleterios@ig.com.br
Andrade
Rosângela V
RV
Pereira
Rinaldo W
RW
Wall
Nathan R
NR
Bahjri
Khaled
K
Caldas
Érica
É
Cavalcante
Larissa
L
Figueiredo
Florêncio
F
D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D053842:Microsatellite Instability; D008875:Middle Aged; D011127:Polyps / Q000235:genetics* / Q000473:pathology; D014591:Uterine Diseases / Q000235:genetics* / Q000473:pathology