title: A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives.
abstract: ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.
authors: School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
authors: Karina C
authors: KC
authors: Gornall
authors: Siritron
authors: S
authors: Samosorn
authors: Bongkot
authors: B
authors: Tanwirat
authors: Apichart
authors: A
authors: Suksamrarn
authors: John B
authors: JB
authors: Bremner
authors: Michael J
authors: MJ
authors: Kelso
authors: Jennifer L
authors: JL
authors: Beck
mesh_terms: D001599:Berberine / Q000031:analogs & derivatives*; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D017705:Lignans; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D017705:Lignans; D001599:Berberine; D004247:DNA