title: Antioxidant, larvicidal and antiacetylcholinesterase activities of cashew nut shell liquid constituents.
abstract: Anacardic acid, cardanol and cardol, the main constituents of natural cashew nut shell liquid (CNSL), were obtained by solvent extraction and assayed for antioxidant, larvicidal and antiacetylcholinesterase activity. Their relative percent composition was obtained by HPLC analysis. Antioxidant activity was assessed using the DPPH and ABTS(+) tests, which showed cardanol as the most active, followed by cardol and anacardic acid. The three CNSL components demonstrated good larvicidal activity against Aedes aegypti (LC(50)=12.40 for anacardic acid, 10.22 for cardol and 14.45 for cardanol) and exhibited inhibition zones for acetylcholinesterase enzymes in the TLC test similar to carbachol, which was used as standard. Based on the results, these multipotent compounds represent promising agents in the control of Ae. aegypti, the main dengue vector in Brazil.
authors: Doutorado de Biotecnologia da Rede Nordeste de Biotecnologia, Av. Paranjana 1700, Campus do Itaperi, Serrinha, Fortaleza, Ceará, Brazil.
authors: Micheline Soares Costa
authors: MS
authors: Oliveira
authors: Selene Maia de
authors: SM
authors: Morais
authors: Davi Varela
authors: DV
authors: Magalhães
authors: Williams Pereira
authors: WP
authors: Batista
authors: Icaro Gusmão Pinto
authors: IG
authors: Vieira
authors: Afrânio Aragão
authors: AA
authors: Craveiro
authors: Jane Eire Silva Alencar
authors: JE
authors: de Manezes
authors: Ana Fontenelle Urano
authors: AF
authors: Carvalho
authors: Glauber Pacelli Gomes
authors: GP
authors: de Lima
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis / Q000378:metabolism; D000330:Aedes / Q000187:drug effects / Q000254:growth & development; D048729:Anacardic Acids / Q000494:pharmacology; D031021:Anacardium / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D003715:Dengue / Q000517:prevention & control; D003716:Dengue Virus; D004199:Disease Vectors; D020128:Inhibitory Concentration 50; D007814:Larva / Q000187:drug effects* / Q000254:growth & development; D009032:Mosquito Control / Q000379:methods; D009754:Nuts / Q000737:chemistry* / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology; D012118:Resorcinols / Q000494:pharmacology
chemical_list: D048729:Anacardic Acids; D000975:Antioxidants; D010636:Phenols; D012118:Resorcinols; C088115:anacardic acid; C038590:cardanol; D000110:Acetylcholinesterase; C041328:adipostatin A