title: Microwave assisted synthesis of a small library of substituted N,N'-bis((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ethers.
abstract: N,N'-bis-((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ether 1a and its analogue 1c are known as fluorescent sensors of magnesium in living cells. With the aim to investigate the effects of the substitution pattern on the photophysical properties of ligands 1 and their metal complexes, we developed an efficient microwaves enhanced one-pot Mannich reaction to double-armed diaza-crown ligands 1 carrying a variety of substituents. This new protocol is characterized by shorter reaction times, enhanced yields, and improved product purities with respect to the use of conventional conductive heating.
authors: Università di Bologna, Dipartimento di Biochimica G. Moruzzi, Bologna, Italy.
authors: Giovanna
authors: G
authors: Farruggia
authors: Stefano
authors: S
authors: Iotti
authors: Marco
authors: M
authors: Lombardo
authors: Chiara
authors: C
authors: Marraccini
authors: Diego
authors: D
authors: Petruzziello
authors: Luca
authors: L
authors: Prodi
authors: Massimo
authors: M
authors: Sgarzi
authors: Claudio
authors: C
authors: Trombini
authors: Nelsi
authors: N
authors: Zaccheroni
mesh_terms: D049109:Cell Proliferation; D002478:Cells, Cultured; D043844:Crown Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008872:Microwaves; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D054852:Small Molecule Libraries; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism; D014018:Tissue Distribution
chemical_list: D043844:Crown Ethers; D005456:Fluorescent Dyes; C554866:N,N'-bis((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ether; D011804:Quinolines; D054852:Small Molecule Libraries