title: [Pulmonary embolism as a cause of a reduced performance capacity of endurance trained men - report of 2 cases].
abstract: METHODS
  Two trained long-distance runners, aged 53 and 58 years, respectively, presented (independently) at our outpatient department because of an acute reduction in physical performance after considerable exertion. Neither had specific clinical symptoms, particularly no dyspnea.
  
  
  METHODS
  Neither patient had abnormal findings on physical examination, such as signs for deep venous thrombosis. The electrocardiogram and echocardiography were normal. Exercise tests revealed a significant limitation in physical performance and, in one patient, a reduction in arterial blood oxygen and elevated d-dimers as the only abnormal laboratory test result.
  
  
  METHODS
  The diagnosis of pulmonary embolism was made by computed tomography, which showed the typical changes. In both patients venous phlebography revealed deep vein thrombosis and signs of post-thrombotic changes. Laboratory tests were unremarkable, with normal blood coagulation and no factor II mutations. Anticoagulants were administered to each patient and they slowly resumed their training program. At a subsequent examination physical performance had improved, but there was still a reduction in arterial oxygen during exercise.
  
  
  CONCLUSIONS
  Even endurance-trained sportspersons without thrombophilic risk factors may develop deep vein thrombosis. Even when there are no symptoms, pulmonary embolism should always be included in the differential diagnosis of a sudden and significant reduction in physical performance.
authors: Medizinische Klinik, Abt. Präventive und Rehabilitative Sportmedizin, Universität Freiburg, Freiburg.
authors: U
authors: U
authors: Korsten-Reck
authors: J
authors: J
authors: Winterer
authors: D
authors: D
authors: König
authors: Hans-Hermann
authors: HH
authors: Dickhuth
mesh_terms: D000208:Acute Disease; D000792:Angiography; D000925:Anticoagulants / Q000627:therapeutic use; D054874:Athletic Performance / Q000502:physiology*; D003937:Diagnosis, Differential; D004562:Electrocardiography; D017984:Enoxaparin / Q000627:therapeutic use; D005080:Exercise Test; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010644:Phenprocoumon / Q000627:therapeutic use; D010807:Physical Endurance / Q000502:physiology*; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012420:Running / Q000502:physiology*; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D010644:Phenprocoumon; D010100:Oxygen