Familial early onset frontotemporal dementia caused by a novel S356T MAPT mutation, initially diagnosed as schizophrenia.
Autosomal dominant frontotemporal dementia (FTD) due to mutations in the MAPT gene is referred to as FTD with parkinsonism linked to chromosome 17 with tau pathology (FTDP-17T). Typically the disease begins in the sixth decade of life. We report a novel exon 12 mutation in MAPT (S356T), in a family with an exceptionally early age at onset (27 and 29 years), causing familial behavioural variant frontotemporal dementia. Both the proband and the proband's father were initially diagnosed as having schizophrenia. Pathological examination showed frontotemporal lobar degeneration with extensive neuronal and glial tau deposition. This mutation is one of a small group of MAPT mutations (including P301S, G335V and S352L) that cause very early onset FTDP-17T. It is likely that the early age at onset reflects a marked pathogenic effect of the mutation involving a disturbance of microtubule binding, tau phosphorylation or a major acceleration of tau aggregation.
Momeni
Parastoo
P
Texas Tech University Health Sciences Center, Department of Internal Medicine, Laboratory of Neurogenetics, Lubbock, TX 79430, USA.
Wickremaratchi
Mirdhu M
MM
Bell
Jason
J
Arnold
Richard
R
Beer
Roger
R
Hardy
John
J
Revesz
Tamas
T
Neal
James W
JW
Morris
Huw R
HR
D000328:Adult; D001921:Brain / Q000473:pathology; D002886:Chromosomes, Human, Pair 17; D004247:DNA / Q000235:genetics; D005260:Female; D057180:Frontotemporal Dementia / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D006801:Humans; D008297:Male; D009154:Mutation / Q000502:physiology*; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000473:pathology; D010766:Phosphorylation; D017397:Prefrontal Cortex / Q000473:pathology; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
C054369:MAPT protein, human; D016875:tau Proteins; D004247:DNA