Role of hepatic portocholecystostomy ('gallbladder Kasai') in treating infants with biliary atresia.
The aim of this study is to compare liver function and cholangitis episodes during the first year postoperatively between patients who undergo hepatic portocholecystostomy (HPC) and patients who undergo hepatic portoenterostomy (HPE). Records of six patients who underwent HPC for biliary atresia (BA) and 27 patients who underwent HPE for BA were reviewed retrospectively. Comparison was done of the patient's total bilirubin, albumin, and international normalized ratio values preoperatively and at 3 months, 6 months, and 1 year postoperatively. Comparison was also done of the occurrence of ascending cholangitis during the first year postoperatively and in rates of transplant and mortality during long-term follow-up. Preoperative laboratory values between the two groups were not significantly different. At 6 months, the patients who underwent HPC had significantly lower total bilirubin levels compared with those who underwent HPE (HPC 0.8 +/- 0.96, n = 4; HPE 4.93 +/- 7.73, n = 21; P < 0.05). No other laboratory values or rates of ascending cholangitis, transplant, or mortality showed a significant difference. Those patients who underwent HPC had significantly lower total bilirubin levels at 6 months postoperatively. This may suggest that HPC may be a superior operative technique for patients who are candidates for the operation.
Johnson
Kevin N
KN
Emory School of Medicine, Atlanta, Georgia, USA. knjohn4@emory.edu
Koontz
Curt S
CS
Ricketts
Richard R
RR
D001656:Biliary Atresia / Q000601:surgery*; D001663:Bilirubin / Q000097:blood; D002761:Cholangitis / Q000209:etiology; D002767:Cholecystostomy / Q000379:methods; D003135:Common Bile Duct / Q000601:surgery; D003549:Cystic Duct / Q000601:surgery; D005704:Gallbladder / Q000601:surgery; D006801:Humans; D007223:Infant; D011171:Portoenterostomy, Hepatic / Q000379:methods*; D011183:Postoperative Complications; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin; D001663:Bilirubin