An enantioselective total synthesis of natural antibiotic marasin.
Synthetic studies directed toward the allenediyne antibiotic marasin are presented. Different approaches to the installation of the optically active chiral allenediyne motif were explored en route to the synthesis of the natural product. The stereoselectivity for the construction of the chiral allenediyne motif was dependent on not only the reaction employed but also the substrate structure.
Zhang
Yan
Y
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Wu
Yikang
Y
D000114:Acetylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis; D002384:Catalysis; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D001688:Biological Products; C511518:marasin; D000114:Acetylene