[Effect of oxysophoridine on electric activities and its power spectrum of reticular formation in rats].
OBJECTIVE
To observe the effect of oxysophoridine (OSR) on the EEG and its power spectrum of reticulum formation in mesencephalon of anaesthetized rat.


METHODS
Utilizing the technique of brain stereotactic apparatus, electrodes were implanted into reticulum formation of mesencephalon. Monopolar lead and computerized FFT technique were employed to record and analyse the index of EEG, power spectrum and frequency distribution in order to study the effect of oxysophoridine on the bioelectricity change of mesencephalon reticulum formation in rats.


RESULTS
After administrating(icy) with oxysophoridine at the dose of 2.5,5, 10 mg/rat, the EEG of mesencephalon reticulum formation mainly characterized with low amplitude and slow waves accompanied by spindle-formed sleeping waves with a significant decrease of total power of EEG (P < 0.05) while the ratio of theta, alpha waves increased in total frequency of rats (P < 0.05).


CONCLUSIONS
Oxysophoridine possesses central inhibitory effects and its inhibitory mechanism may associate with the reduction of bioelectricity in mesencephalon reticulum formation. Mesencephalon reticulum formation may serve as one part of the structure serving as the circuit conducting the central inhibitory effect of oxysophoridine. [Key words] oxysophoridine; reticulum formation; electroencephalogram (EEG) ; rats
Yu
Jianqiang
J
Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. jiangyuanxu33@163.com
Li
Yuxiang
Y
Zhao
Chengjun
C
Gong
Xin
X
Liu
Jianping
J
Wang
Feng
F
Jiang
Yuanxu
Y
D000470:Alkaloids / Q000008:administration & dosage*; D000818:Animals; D004569:Electroencephalography; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012154:Reticular Formation / Q000187:drug effects* / Q000502:physiology*
D000470:Alkaloids; C406983:oxysophoridine