Mammalian PGRPs also mind the fort.
Peptidoglycan recognition proteins (PGRPs or Pglyrps) regulate antibacterial responses in Drosophila, yet their functions in humans remain unclear. In this issue of Cell Host & Microbe, Saha and colleagues report that mammalian PGRPs can prevent aberrant interferon-gamma--induced inflammatory damage in vivo by modulating the composition of the intestinal bacterial flora.
Rubino
Stephen
S
Department of Laboratory Medicine and Pathobiology, University of Toronto, M6G 2T6, Toronto, Ontario, Canada. stephen.girardin@utoronto.ca
Lee
Jooeun
J
Girardin
Stephen E
SE