title: Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties.
abstract: A series of fatty acid amides of 3,4-methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB(1) receptor and/or PPAR-α; part of their biological activity may be caused by these double interactions.
authors: Human Pharmacology and Clinical Neurosciences Research Group, IMIM-Hospital del Mar Research Institute, Barcelona 08003, Spain.
authors: Bruno
authors: B
authors: Almeida
authors: Jesús
authors: J
authors: Joglar
authors: María Jesús
authors: MJ
authors: Luque Rojas
authors: Juan Manuel
authors: JM
authors: Decara
authors: Francisco Javier
authors: FJ
authors: Bermúdez-Silva
authors: Manuel
authors: M
authors: Macias-González
authors: Montserrat
authors: M
authors: Fitó
authors: Miguel
authors: M
authors: Romero-Cuevas
authors: Magí
authors: M
authors: Farré
authors: María Isabel
authors: MI
authors: Covas
authors: Fernando
authors: F
authors: Rodríguez de Fonseca
authors: Rafael
authors: R
authors: de la Torre
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D019440:Anti-Obesity Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry / Q000378:metabolism*; D005227:Fatty Acids / Q000737:chemistry*; D007700:Kinetics; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000737:chemistry / Q000378:metabolism; D047493:PPAR alpha / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000737:chemistry / Q000378:metabolism
chemical_list: D000577:Amides; D019440:Anti-Obesity Agents; D002396:Catechols; D005227:Fatty Acids; D047493:PPAR alpha; D043884:Receptor, Cannabinoid, CB1; D018817:N-Methyl-3,4-methylenedioxyamphetamine; C034221:catechol