Region-specific involvement of actin rearrangement-related synaptic structure alterations in conditioned taste aversion memory.
Actin rearrangement plays an essential role in learning and memory; however, the spatial and temporal regulation of actin dynamics in different phases of associative memory has not been fully understood. Here, using the conditioned taste aversion (CTA) paradigm, we investigated the region-specific involvement of actin rearrangement-related synaptic structure alterations in different memory processes. We found that CTA training could induce increased postsynaptic density (PSD) length in insular cortex (IC), but not in basolateral amygdala (BLA) and prelimbic cortex (PrL) during short-term memory (STM) formation, whereas it led to increased PSD length and synapse density in both IC and PrL during long-term memory (LTM) formation. Inhibition of actin rearrangement in the IC, but not in the BLA and PrL, impaired memory acquisition. Furthermore, actin dynamics in the IC or PrL is necessary for memory consolidation. On the contrary, inhibition of actin dynamics in the IC, BLA, or PrL had no effect on CTA memory retrieval. Our results suggest temporal and regional-specific regulation of actin rearrangement-related synaptic structure in different phases of CTA memory.
Bi
Ai-Ling
AL
Department of Neurobiology, Shandong University, Jinan, People's Republic of China.
Wang
Yue
Y
Li
Bo-Qin
BQ
Wang
Qian-Qian
QQ
Ma
Ling
L
Yu
Hui
H
Zhao
Ling
L
Chen
Zhe-Yu
ZY
D000199:Actins / Q000378:metabolism / Q000648:ultrastructure*; D000679:Amygdala / Q000378:metabolism / Q000648:ultrastructure; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000648:ultrastructure*; D003214:Conditioning, Classical / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012153:Retention, Psychology / Q000502:physiology*; D018709:Statistics, Nonparametric; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure*; D013997:Time Factors
D000199:Actins