title: [High-dose-rate brachytherapy with external beam radiotherapy for localized or locally advanced prostate cancer].
abstract: OBJECTIVE
  To evaluate the therapeutic outcomes and late toxicities in patients treated by high-dose-rate brachytherapy (HDR-BT) with external beam radiotherapy (EBRT) for localized or locally advanced prostate cancer.
  
  
  METHODS
  From May 2004 to September 2008, 86 men were treated by HDR-BT with EBRT for localized or locally advanced prostate cancer at the National Hospital Organization Kyushu Medical center. The median EBRT and HDR-BT doses were 40 Gy and 30 Gy, respectively.
  
  
  RESULTS
  With a median follow-up of 24 months, the 3-year overall, disease specific, and biochemical relapse-free survival rates in all patients were 97.3%, 100%, and 83.6% respectively. The 3-year biochemical relapse-free survival rate of the patients categorized to low or intermediate risk group (91.8%) was significantly better than that of the patients categorized to the high risk group (74.3%) (p = 0.042). There was no significant difference of biochemical relapse-free survival regarding to the other clinical factors (age, T-stage, Gleason score, initial prostate-specific antigen level, neoadjuvant hormone therapy, and total dose of EBRT and HDR-BT). Late Grade2 and Grade3 gastrointestinal toxicities were observed in 8 patients (9.3%) and 2 patients (2.3%), respectively. Late Grade2 genitourinary toxicities were observed in 12 patients (13.9%). There was no patient suffered from late Grade3 or greater genitourinary toxicities.
  
  
  CONCLUSIONS
  HDR-BT with EBRT can be safe and effective for localized or locally advanced prostate cancer.
authors: Department of Radiology, National Hospital Organization Fukuoka Higashi Medical Center, Japan.
authors: Akira
authors: A
authors: Matsunobu
authors: Yoshiyuki
authors: Y
authors: Shioyama
authors: Satoru
authors: S
authors: Uehara
authors: Saiji
authors: S
authors: Ohga
authors: Kazushige
authors: K
authors: Atsumi
authors: Taisei
authors: T
authors: Matsumura
authors: Naotaka
authors: N
authors: Sakamoto
authors: Masahiro
authors: M
authors: Yoshikawa
authors: Atsushi
authors: A
authors: Iguchi
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage