title: Pursuit ocular movements in multiple sclerosis: a video-based eye-tracking study.
abstract: Multiple sclerosis (MS) patients frequently develop some form of ocular motor dysfunction during the disease. In previous studies, ocular motor abnormalities were found to correlate with clinical disability and with impaired cognitive performance. The objective of this study was to assess the pursuit ocular movement (POM) frequency in relapsing-remitting (RR) and secondary progressive (SP) MS patients by using a vision-based non-intrusive eye tracker. POM frequency was significantly lower (p < 0.001) in MS patients compared to normal controls. No differences between RR and SP-MS patients and no correlation between POM and expanded disability status scale (EDSS) score were found. This exploratory study suggests that our vision-based system is a new simple non-intrusive method showing impairment of POM values in MS patients, even in the absence of association with clinical disability (EDSS). Future works on larger cohorts of MS patients might validate this eye tracking in MS clinical practice.
authors: IRCCS Centro Neurolesi, Bonino-Pulejo, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy. lorenzo.desanti@centroneurolesi.it
authors: Lorenzo
authors: L
authors: De Santi
authors: Pietro
authors: P
authors: Lanzafame
authors: Barbara
authors: B
authors: Spanò
authors: Giangaetano
authors: G
authors: D'Aleo
authors: Alessia
authors: A
authors: Bramanti
authors: Placido
authors: P
authors: Bramanti
authors: Silvia
authors: S
authors: Marino
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000209:etiology*; D012438:Saccades / Q000502:physiology*; D018709:Statistics, Nonparametric; D014741:Video Recording / Q000379:methods