title: Childhood lupus: experience from Eastern India.
abstract: OBJECTIVE
  To delineate the clinical behavior of SLE in children from Eastern India and to the differences in disease pattern.
  
  
  METHODS
  In the present study, all 44 patients of pediatric SLE who were diagnosed over a period of 5 years in our pediatric rheumatology clinic were followed prospectively. The resultant database was analyzed using standard statistical methods.
  
  
  RESULTS
  about 3.9% of all rheumatology cases dealt with in the clinic in the last five yrs (n=1063) were sle. the number of children in 5-8 yrs and 8-12 yrs age groups were 13 and 27, respectively. the overall female (n=35) to male (n=9) ratio in this study was 3.8:1. renal, hematological and neuropsychiatric features were most common major organ manifestations(54%,54% and 25% respectively). joints and skin were the most common minor organs involved. two case were ana negative sle. among the typical features of ana negative disease, only nephritis was found in these patients. anti dsdna was positive in 50 % cases (n=21). c3 levels were studied in all cases with nephritis (n=22) and 68 % (n=15) had hypocomplementemia. anti ro and anti la antibodies were positive in two cases of neonatal lupus. APLA, ANTI SM antibody AND ANTI U1RNP were negative in the cases where testing was done:
  
  
  CONCLUSIONS
  This study has tried to delineate the disease trends of childhood lupus from Eastern India. Certain important trends have emerged which are different from other contemporary Indian and International observations.
authors: Pediatric Rheumatology Clinic, Department of Pediatrics, Institute of Post graduate Medical Education and Research, Kolkata, India.
authors: Rakesh
authors: R
authors: Mondal
authors: Madhumita
authors: M
authors: Nandi
authors: Suhas
authors: S
authors: Ganguli
authors: Alokendu
authors: A
authors: Ghosh
authors: Avijit
authors: A
authors: Hazra
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital / Q000276:immunology; D008181:Lupus Nephritis / Q000150:complications / Q000276:immunology; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000276:immunology; D008297:Male; D011446:Prospective Studies; D017678:Sex Distribution
chemical_list: D000974:Antibodies, Antinuclear