Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids.
OBJECTIVE
The objectives of this article are to review the radiologic, pathologic, and clinical features of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids and to discuss the possible role of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and tumorlet in the development of carcinoids.


CONCLUSIONS
Given the potential significant morbidity of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and its neoplastic counterparts, it is important to understand and recognize these disease entities. A conceptual continuum of these neuroendocrine entities is suggested.
Koo
Chi Wan
CW
Department of Radiology, New York University Langone Medical Center, 560 First Ave., IRM 236, New York, NY 10016, USA. ChiWan.Koo@nyumc.org
Baliff
Jeffrey P
JP
Torigian
Drew A
DA
Litzky
Leslie A
LA
Gefter
Warren B
WB
Akers
Scott R
SR
D002276:Carcinoid Tumor / Q000000981:diagnostic imaging / Q000473:pathology*; D049109:Cell Proliferation; D003287:Contrast Media; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D055099:Neuroendocrine Cells / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging / Q000473:pathology*; D009490:Neurosecretory Systems / Q000473:pathology; D011230:Precancerous Conditions / Q000000981:diagnostic imaging / Q000473:pathology; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D003287:Contrast Media