Biochemical sensing with a polymer-based micromachined Fabry-Perot sensor.
A white-light source operated polymer-based micromachined Fabry-Perot biochemical sensor is reported. As a refractive-index sensitive optical sensor, its transducing signal varies upon the changes of the effective refractive index in the Fabry-Perot cavity. This sensor is fabricated from PDMS and glass. More specifically, this sensor is a micromachined Fabry-Perot interferometer (microFPI) and is fabricated by bonding a glass substrate and the soft-lithographically patterned PDMS. Several biochemicals have been detected with the microFPI biochemical sensors. Measurements show that rabbit IgG at a concentration of as low as 5 to 50 ng/ml can be detected even without any performance optimization of the devices.
Zhang
Tianhua
T
Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA 71272, USA.
Talla
Shantan
S
Gong
Zhongcheng
Z
Karandikar
Sukrut
S
Giorno
Rebecca
R
Que
Long
L
D000818:Animals; D055910:Antibodies, Immobilized / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004867:Equipment Design; D005898:Glass / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D007368:Interferometry / Q000295:instrumentation / Q000379:methods*; D055616:Microtechnology / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D009757:Nylons / Q000737:chemistry*; D011817:Rabbits
D055910:Antibodies, Immobilized; D004129:Dimethylpolysiloxanes; D007074:Immunoglobulin G; D009757:Nylons; C085707:poly(dimethylsiloxane)-polyamide copolymer