title: Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors.
abstract: Detection of recurrent somatic rearrangements routinely allows monitoring of residual disease burden in leukemias, but is not used for most solid tumors. However, next-generation sequencing now allows rapid identification of patient-specific rearrangements in solid tumors. We mapped genomic rearrangements in three cancers and showed that PCR assays for rearrangements could detect a single copy of the tumor genome in plasma without false positives. Disease status, drug responsiveness, and incipient relapse could be serially assessed. In future, this strategy could be readily established in diagnostic laboratories, with major impact on monitoring of disease status and personalizing treatment of solid tumors.
authors: Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.
authors: David J
authors: DJ
authors: McBride
authors: Arto K
authors: AK
authors: Orpana
authors: Christos
authors: C
authors: Sotiriou
authors: Heikki
authors: H
authors: Joensuu
authors: Philip J
authors: PJ
authors: Stephens
authors: Laura J
authors: LJ
authors: Mudie
authors: Eija
authors: E
authors: Hämäläinen
authors: Lucy A
authors: LA
authors: Stebbings
authors: Leif C
authors: LC
authors: Andersson
authors: Adrienne M
authors: AM
authors: Flanagan
authors: Virginie
authors: V
authors: Durbecq
authors: Michail
authors: M
authors: Ignatiadis
authors: Olli
authors: O
authors: Kallioniemi
authors: Caroline A
authors: CA
authors: Heckman
authors: Kari
authors: K
authors: Alitalo
authors: Henrik
authors: H
authors: Edgren
authors: P Andrew
authors: PA
authors: Futreal
authors: Michael R
authors: MR
authors: Stratton
authors: Peter J
authors: PJ
authors: Campbell
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology