Per-6-amino-β-cyclodextrin as a reusable promoter and chiral host for enantioselective Henry reaction.
A highly efficient enantioselective Henry reaction has been carried out using per-6-ABCD as a supramolecular chiral host and promoter to give the corresponding adduct with high yield (up to 99%) and enantiomeric excess (up to 99%). Per-6-ABCD also promotes the diastereoselective Henry reaction in a syn-selective manner to give the adduct up to 99% yield with 99:1 syn/anti selectivity. The enantiomeric excess of the syn-adduct is 99%. The catalyst is recovered and reused without loss in its activity.
Kanagaraj
Kuppusamy
K
School of Chemistry, Madurai Kamaraj University, Madurai-625021, India.
Suresh
Palaniswamy
P
Pitchumani
Kasi
K
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000447:Aldehydes; D047392:beta-Cyclodextrins; C534165:per-6-amino-beta-cyclodextrin