title: Thyroid function and 3,3'-diiodothyronine sulfate cross-reactive substance (compound W) in maternal hyperthyroidism with antithyroid treatment.
abstract: OBJECTIVE
  To test whether the serial measurement of maternal levels of compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance, can serve as a potential indicator of fetal thyroid function in pregnant women receiving antithyroid medication.
  
  
  METHODS
  Compound W was measured repeatedly in serum of pregnant women with hyperthyroidism treated with antithyroid medication. Free thyroxine levels of mothers and serum thyroid-stimulating hormone levels of 1-day-old neonates were analyzed by local clinical or state laboratories.
  
  
  RESULTS
  Use of minimal antithyroid medication impaired the progressive increase of compound W seen in euthyroid mothers during pregnancy. At term, depressed compound W levels in maternal serum were found in 7 of 22 pregnancies; in 1 case, maternal compound W was suppressed and newborn thyroid-stimulating hormone was elevated. Seven mothers with treated hyperthyroidism failed to show an increase in serum levels of compound W after midterm.
  
  
  CONCLUSIONS
  Normal progression of maternal serum compound W may be an index of normal fetal thyroid development in mothers with hyperthyroidism treated with necessary antithyroid medication.
authors: Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors: Lester
authors: L
authors: Vanmiddlesworth
authors: N Rue
authors: NR
authors: Vanmiddlesworth
authors: Robert S
authors: RS
authors: Egerman
authors: Andrew J
authors: AJ
authors: Bush
authors: Risa D
authors: RD
authors: Ramsey
authors: Lucinda P
authors: LP
authors: Delmar
authors: Eugene C
authors: EC
authors: Ho
authors: Sing-Yung
authors: SY
authors: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004104:Diiodothyronines / Q000097:blood*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy*; D007231:Infant, Newborn; D011247:Pregnancy; D013961:Thyroid Gland / Q000196:embryology*; D013974:Thyroxine / Q000097:blood; D055815:Young Adult
chemical_list: D013956:Antithyroid Agents; D004104:Diiodothyronines; C404304:compound W; D013974:Thyroxine