[Regulation of the JNK signaling pathway by dual leucine zipper kinase DLK.].
The C-Jun NH2-terminal kinase (JNK) belongs to the evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases family. Many studies have shown that JNK pathway plays physiological roles in cell proliferation, differentiation, migration and apoptosis, and its deregulation has been associated with developmental defects and various human diseases. Dual leucine zipper kinase (DLK) is a member of the mixed-lineage kinases that performs important cellu-lar functions as a MAP triple kinase (MAPKKK) in regulating the JNK signaling pathway. In this paper, we described the DLK protein structures, physiological roles, and their functional interactions with JNK signaling, as well as the molecular mechanisms underlying their involvement in various human diseases.
Ma
Xian-Jue
XJ
School of Life Science and Technology, Tongji University, Shanghai, China. ma-tianzun@163.com
Xue
Lei
L
D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology*; D020930:MAP Kinase Kinase Kinases / Q000032:analysis / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology*
D048031:JNK Mitogen-Activated Protein Kinases; D020930:MAP Kinase Kinase Kinases; C090757:mitogen-activated protein kinase kinase kinase 12