title: [Imaging features and clinicopathological manifestations of solitary fibrous tumors].
abstract: OBJECTIVE
  To investigate the imaging features, clinical manifestations and pathological characteristics of solitary fibrous tumors (SFT).
  
  
  METHODS
  The clinicopathological manifestations and medical imaging findings were analyzed retrospectively in 27 patients with surgically confirmed SFT.
  
  
  RESULTS
  The SFTs originated from different parts of the body, including 18 in the chest, 4 in the abdomen, 1 in the lumboscral area, 3 in the pelvis, and 1 in the left shoulder. Twenty-three cases were found by CT scan, among which there were 16 benign diseases, presented with well-defined round or elliptic margins, with homogeneous attenuation and clearly surrounding; 6 malignant cases with unclear demarcations, invasive surrounding, heterogeneous attenuation due to calcification and/or irregular necrosis, and 1 junctional case with well-defined margins, which was enlarged during follow-up. There were 4 SFTs scanned by MRI with clear margin and homogeneous or heterogeneous signal intensity. All of the 4 cases were isointense or hyperintense to muscle on T1-weighted images, and were hyperintense on the T2-weighted images. All tumors showed heterogeneously intense enhancement with geographic pattern. Immunohistochemical staining showed that CD34-positive was 81.5%, vimentin (100.0%), CD99 (100.0%) and bcl-2 (96.3%), as well as negative CK (100.0%) and S-100 (96.3%).
  
  
  CONCLUSIONS
  The location of SFT is varying. Though its clinical manifestations vary, the diagnosis is depended on pathology and immunohistochemistry. There are certain specific features related to SFTs on CT or MRI. These imaging techniques may serve to provide helpful information as to the location and vicinal anatomic structure of the tumor, which is of substantial importance for planning surgery.
authors: Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Jian-peng
authors: JP
authors: Li
authors: Chuan-miao
authors: CM
authors: Xie
authors: Rong
authors: R
authors: Zhang
authors: Hui
authors: H
authors: Li
authors: Xue-wen
authors: XW
authors: Liu
authors: Yun
authors: Y
authors: Zhang
authors: Shao-han
authors: SH
authors: Yin
authors: Yan-chun
authors: YC
authors: Lü
authors: Zhi-jun
authors: ZJ
authors: Geng
mesh_terms: D000071443:12E7 Antigen; D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D054363:Solitary Fibrous Tumor, Pleural / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D054364:Solitary Fibrous Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D036542:Tomography, Spiral Computed; D014746:Vimentin / Q000378:metabolism; D055815:Young Adult
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D014746:Vimentin