The microRNA pathway and cancer.
MicroRNAs (miRNAs) are ∼22nt long, non-coding RNAs that guide post-transcriptional gene silencing of their target genes and regulate diverse biological processes including cancer. miRNAs do not act alone, but require assembly into RNA-induced silencing complex (RISC). In this review, we summarize how miRNAs are produced, assembled into RISC, and regulate target mRNAs, and discuss how the miRNA pathway is involved in cancer.
Kwak
Pieter Bas
PB
Institute of Molecular and Cellular Biosciences Department of Medical Genome Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Iwasaki
Shintaro
S
Tomari
Yukihide
Y
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D035683:MicroRNAs; D012333:RNA, Messenger; D034743:RNA-Induced Silencing Complex