[Mechanism of the cardioprotective effect of nifedipine in rabbits under vibration exposure conditions].
Mechanisms of the vibroprotective action of nifedipine, a calcium channel blocker, have been studied in myocardiocytes of rabbits. Changes in the functional activity of mitochondria were observed in rabbits after prolonged (56 days) general vibration. Nifedipine (7.5 mg/kg per os) activated the NAD-dependent site of respiratory chain and prevented hyperactivation of the succinate-dependent breath. The positive energotropic action of nifedipine was accompanied by stability of the histomorphological cytoarchitecture of rabbit myocardium. It is suggested that nifedipine protects myocardium from negative effects of prolonged vibration.
Vorob'eva
V V
VV
Mazina
N K
NK
Shabanov
P D
PD
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D009543:Nifedipine / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014732:Vibration / Q000009:adverse effects*
D002121:Calcium Channel Blockers; D002316:Cardiotonic Agents; D009543:Nifedipine