Checks and balances: IL-23 in the intestine.
In this issue of Immunity, Ahern et al. (2010) show that IL-23R signaling in CD4(+) T cells induces effector and suppresses regulatory CD4(+) T cells, which is critical for the development of intestinal, but not systemic, inflammation.
Huber
Samuel
S
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Flavell
Richard A
RA