The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue?
The endogenous lipids that control the functions of invariant natural killer T (iNKT) cells remain enigmatic. In this issue of Immunity, Darmoise et al. (2010) report that lysosomal alpha-galactosidase A destroys self-antigens recognized by iNKT cells.
Van Kaer
Luc
L
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. luc.van.kaer@vanderbilt.edu
Joyce
Sebastian
S