title: Stent thrombosis following 2 drug-eluting stent implantations for coronary bifurcation lesion: a single-center analysis.
abstract: BACKGROUND
  The incidence of stent thrombosis (ST) following 2 drug-eluting stent (DES) implantations for coronary bifurcation lesions needs to be identified.
  
  
  METHODS
  From April 2004 to April 2009, 705 consecutive patients with true bifurcation lesions who underwent a double stenting procedure with DES at the Fu Wai Hospital were analyzed.
  
  
  RESULTS
  Six (0.85%) patients had a definite ST, all of them had an early (4 acute and 2 subacute) definite ST. Probable ST occurred in 4 patients; in all of these cases, the event occurred early and was adjudicated because of the occurrence of sudden death within 30 days of the procedure. Therefore, a total of 10/705 (1.42%) patients had a definite or probable ST. Possible stent thrombosis was adjudicated only in 1 patient 371 days after the initial PCI in whom the cause of death was unexplained. Compared to the patients without definite and probable ST, patients with definite and probable ST were older, had more unstable angina, lower LVEF, and more left main bifurcation lesions (63.2 +/- 8.9 vs. 56.8 +/- 10.9 yrs; P = 0.049, 100% vs. 64.7%; P = 0.018, 50.6 +/- 9.9 vs. 60.3 +/- 12.4%; P = 0.019 and 70.0% vs. 36.1%; P = 0.043). Logistic analysis results indicated that only LVEF (OR 0.92, 95% CI 0.87-0.93; P = 0.017) was associated with definite and probable ST.
  
  
  CONCLUSIONS
  The present study indicates that modern 2-DES technique for bifurcation lesions was comparatively safe with a low incidence of ST.
authors: Department of Cardiology, Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
authors: Zhan
authors: Z
authors: Gao
authors: Bo
authors: B
authors: Xu
authors: Yuejin
authors: Y
authors: Yang
authors: Jilin
authors: J
authors: Chen
authors: Shubin
authors: S
authors: Qiao
authors: Jian-Jun
authors: JJ
authors: Li
authors: Xuewen
authors: X
authors: Qin
authors: Yongjian
authors: Y
authors: Wu
authors: Min
authors: M
authors: Yao
authors: Jinqing
authors: J
authors: Yuan
authors: Jue
authors: J
authors: Chen
authors: Haibo
authors: H
authors: Liu
authors: Jun
authors: J
authors: Dai
authors: Run-Lin
authors: RL
authors: Gao
mesh_terms: D000367:Age Factors; D000368:Aged; D000789:Angina, Unstable / Q000453:epidemiology; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000628:therapy; D023903:Coronary Restenosis / Q000453:epidemiology; D023921:Coronary Stenosis / Q000628:therapy*; D003328:Coronary Thrombosis / Q000453:epidemiology* / Q000209:etiology; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D013318:Stroke Volume