Biodistribution of technetium-99m pertechnetate after total colectomy in rats.
This study evaluated the effects of total colectomy on the biodistribution of technetium-99m pertechnetate ((99m)TcO(4)(-)) on the 28th postoperative day in rats. Samples of several organs were harvested for counting the percent of injected radioactivity/g of tissue (%ATI/g). The %ATI/g in colectomy rats was higher in the stomach and ileum than in sham and controls (p<0.05). Increase in mucosa and muscularis size of ileum was observed. Colectomy was associated with lower biodistribution in bladder and thyroid, T3, and T4, than in controls.
Rêgo
Amália Cínthia Meneses
AC
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Ave. Miguel Alcides Araújo 1889, Natal-RN 59078-270, Brazil.
Ramalho
Rachel Alcântara Oliveira
RA
Egito
Eryvaldo Sócrates Tabosa
ES
Araújo-Filho
Irami
I
Azevedo
Italo Medeiros
IM
Palestro
Christopher J
CJ
Medeiros
Aldo Cunha
AC
D000818:Animals; D001835:Body Weight; D003082:Colectomy; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D013670:Sodium Pertechnetate Tc 99m