Heart-type fatty acid binding protein is an early marker of myocardial damage after radiofrequency catheter ablation.
OBJECTIVE
Radiofrequency (RF) ablation of arrhythmias induces myocardial damage and release of biomarkers. This study aimed to assess the kinetics of heart-type fatty acid-binding protein (h-FABP), a cytosolic protein released after myocardial injury incurred by both atrial and ventricular RF ablation, compared to other markers of myocardial injury.


METHODS
h-FABP, cTnI, CK-MB(mass) and myoglobin were evaluated in 30 patients with atrial or ventricular tachyarrhythmias before, immediately after and at 3, 6 and 24h after the procedure.


RESULTS
h-FABP increased immediately after the procedure in all subjects (6.6 ± 1.2 μg/L vs 2.7 ± 0.3, p<0.001) but increased significantly only in ventricular ablations. The peak of h-FABP significantly correlates with the values of time for mean power of RF application in both the entire patient cohort and in ventricular ablations.


CONCLUSIONS
h-FABP may be an early parameter for monitoring RF-induced lesions and the site of ablation was relevant for biomarker increase.
Giannessi
Daniela
D
CNR Institute of Clinical Physiology and Fondazione Toscana G. Monasterio, Pisa, Italy. danielag@ifc.cnr.it
Piacenti
Marcello
M
Maltinti
Maristella
M
Rossi
Andrea
A
Di Cecco
Pietro
P
Startari
Umberto
U
Cabiati
Manuela
M
Panchetti
Luca
L
Del Ry
Silvia
S
Morales
Maria-Aurora
MA
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D017115:Catheter Ablation / Q000009:adverse effects*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D012016:Reference Values; D012044:Regression Analysis; D013997:Time Factors
D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins