title: High susceptibility of obese hypertensive SHRSP.Z-Lepr(fa) /IzmDmcr rats to lipid deposition in the mesenteric artery.
abstract: 1. Atherosclerosis is commonly observed in obesity. Obese atherosclerosis-prone animals may be a promising tool for understanding the pathophysiology of obesity-associated atherosclerosis. However, most rat strains are resistant to atherosclerosis. The aim of the present study was to assess the susceptibility of two obese hypertensive rat models, namely SHRSP.Z-Lepr(fa) /IzmDmcr rats (SHRSP-fatty) and SHR.Cg-Lepr(cp) /NDmcr rats (SHR-cp), to arterial lipid deposition, an initial stage of atherosclerosis, by comparing these strains with non-obese stroke-prone spontaneously hypertensive rats (SHRSP). 2. Eight-week-old male SHRSP, SHRSP-fatty and SHR-cp were fed a high-fat and high-cholesterol diet containing 20% palm oil, 5% cholesterol and 2% cholic acid for 5weeks. Bodyweight, blood pressure and fasting serum levels of total cholesterol and triglycerides were measured in 12-week-old rats. Oil red O staining was used to visualize lipid deposition in the mesenteric artery. 3. The bodyweight of 12-week-old SHRSP-fatty and SHR-cp was higher than that of SHRSP (P<0.005). Systolic blood pressure in SHRSP and SHRSP-fatty was higher than in SHR-cp (P<0.005). Serum total cholesterol and triglyceride levels were elevated in SHRSP-fatty (P<0.005) and SHR-cp (P<0.05) compared with levels in SHRSP. Lipid deposition in the mesenteric artery was significantly greater in SHRSP-fatty than in SHRSP (37.7±4.9 vs 13.1±2.8%, respectively; P<0.005), but markedly reduced in SHR-cp (1.8±0.4%; P<0.05). 4. The results of the present study indicate that SHRSP-fatty are highly susceptible to arterial lipid deposition, whereas SHR-cp are resistant. Thus, SHRSP-fatty may be a useful obese rat model in which to investigate atherosclerotic processes.
authors: Institute for World Health Development, Mukogawa Women's University, Nishinomiya, Japan.
authors: Kazuhiro
authors: K
authors: Kunimasa
authors: Hisae
authors: H
authors: Yoshitomi
authors: Chitose
authors: C
authors: Miura
authors: Hideki
authors: H
authors: Mori
authors: Satoru
authors: S
authors: Tsuchikura
authors: Katsumi
authors: K
authors: Ikeda
authors: Ming
authors: M
authors: Gao
authors: Yukio
authors: Y
authors: Yamori
authors: Mari
authors: M
authors: Mori
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism; D001835:Body Weight; D004195:Disease Models, Animal; D006973:Hypertension / Q000150:complications* / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism*; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008055:Lipids