Oxidative stress fine-tunes the dance of hERG K+ channels.
Vandenberg
Jamie I
JI
Victor Chang Cardiac Research Institute and St Vincent's Clinical School, University of New South Wales, Level 6, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia. j.vandenberg@victorchang.edu.au
D003545:Cysteine; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D007700:Kinetics; D008564:Membrane Potentials; D008958:Models, Molecular; D016877:Oxidants / Q000494:pharmacology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D026902:Potassium Channel Blockers / Q000494:pharmacology; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D017382:Reactive Oxygen Species / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D013439:Sulfhydryl Reagents / Q000494:pharmacology
D051638:Ether-A-Go-Go Potassium Channels; C496884:KCNH1 protein, human; D016877:Oxidants; D026902:Potassium Channel Blockers; D017382:Reactive Oxygen Species; D011994:Recombinant Proteins; D013439:Sulfhydryl Reagents; D003545:Cysteine