title: Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
abstract: African trypanosomiasis is a severe parasitic disease that affects both humans and livestock. Several different species may cause animal trypanosomosis and although Trypanosoma vivax (sub-genus Duttonella) is currently responsible for the vast majority of debilitating cases causing great economic hardship in West Africa and South America, little is known about its biology and interaction with its hosts. Relatively speaking, T. vivax has been more than neglected despite an urgent need to develop efficient control strategies. Some pioneering rodent models were developed to circumvent the difficulties of working with livestock, but disappointedly were for the most part discontinued decades ago. To gain more insight into the biology of T. vivax, its interactions with the host and consequently its pathogenesis, we have developed a number of reproducible murine models using a parasite isolate that is infectious for rodents. Firstly, we analyzed the parasitical characteristics of the infection using inbred and outbred mouse strains to compare the impact of host genetic background on the infection and on survival rates. Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. The models developed are consistent with field observations and pave the way for subsequent in-depth studies into the pathogenesis of T. vivax - trypanosomosis.
authors: Laboratoire d'Immunobiologie des Infections à Trypanosoma, Département d'Immunologie, Institut Pasteur, Paris, France.
authors: Nathalie
authors: N
authors: Chamond
authors: Alain
authors: A
authors: Cosson
authors: Marie Christine
authors: MC
authors: Blom-Potar
authors: Grégory
authors: G
authors: Jouvion
authors: Simon
authors: S
authors: D'Archivio
authors: Mathieu
authors: M
authors: Medina
authors: Sabrina
authors: S
authors: Droin-Bergère
authors: Michel
authors: M
authors: Huerre
authors: Sophie
authors: S
authors: Goyard
authors: Paola
authors: P
authors: Minoprio
mesh_terms: D000740:Anemia / Q000469:parasitology; D000825:Animal Structures / Q000469:parasitology / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016019:Survival Analysis; D016689:Trypanosoma vivax / Q000472:pathogenicity*; D014353:Trypanosomiasis, African / Q000469:parasitology* / Q000473:pathology*