title: Difficulty in sustaining hepatic outflow in left lobe but not right lobe living donor liver transplantation.
abstract: BACKGROUND
  Hepatic outflow block is one of the major complications leading to severe graft dysfunction after left lobe living donor liver transplantation (LDLT).
  
  
  METHODS
  Medical records of 46 recipients of a left lobe LDLT were reviewed. The method of outflow reconstruction and post-transplant morphological changes of hepatic veins were investigated. The subjects were followed up until September 2008, with a median follow-up period of 2.0 yr (range: 0.5-5.9 yr).
  
  
  RESULTS
  There were no multiple outflow tracts to be reconstructed, and the median caliber of the single orifices with or without venoplasty was 32.0 mm. The difference between the angle of hepatic veins to the sagittal plane measured on computed tomography was calculated for pre-operative donors and post-operative recipients a month after LDLT. Both left and middle hepatic veins showed a significantly greater change in angle than the right hepatic vein. Both left and middle hepatic veins more frequently showed a nearly flat wave form on Doppler study one month after LDLT. In the 46 recipients of left lobe grafts, three developed outflow block (6.5%).
  
  
  CONCLUSIONS
  The middle and left hepatic veins tend to distort and stretch during graft regeneration. These characteristics seem to be associated with outflow disturbances.
authors: Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan. shirouzu@fc.kuh.kumamoto-u.ac.jp
authors: Yasumasa
authors: Y
authors: Shirouzu
authors: Yuki
authors: Y
authors: Ohya
authors: Shintarou
authors: S
authors: Hayashida
authors: Katsuhiro
authors: K
authors: Asonuma
authors: Yukihiro
authors: Y
authors: Inomata
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006503:Hepatic Veins / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D014057:Tomography, X-Ray Computed; D055815:Young Adult