title: Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.
abstract: OBJECTIVE
  Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD.
  
  
  METHODS
  Families were ascertained at Massachusetts General Hospital (MGH; N = 309 trios), Washington University at St. Louis (WASH-U; N = 272 trios), and University of California at Los Angeles (UCLA; N = 156 trios). Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. After applying quality control filters, association with ADHD was tested with 835,136 SNPs in 735 DSM-IV ADHD trios from 732 families.
  
  
  RESULTS
  Our smallest p value (6.7E-07) did not reach the threshold for genome-wide statistical significance (5.0E-08), but one of the 20 most significant associations was located in a candidate gene of interest for ADHD (SLC9A9, rs9810857, p = 6.4E-6). We also conducted gene-based tests of candidate genes identified in the literature and found additional evidence of association with SLC9A9.
  
  
  CONCLUSIONS
  We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders.
authors: Massachusetts General Hospital, 55 Fruit Street-Warren 705, Boston, MA 02114, USA. emick1@partners.org
authors: Eric
authors: E
authors: Mick
authors: Alexandre
authors: A
authors: Todorov
authors: Susan
authors: S
authors: Smalley
authors: Xiaolan
authors: X
authors: Hu
authors: Sandra
authors: S
authors: Loo
authors: Richard D
authors: RD
authors: Todd
authors: Joseph
authors: J
authors: Biederman
authors: Deirdre
authors: D
authors: Byrne
authors: Bryan
authors: B
authors: Dechairo
authors: Allan
authors: A
authors: Guiney
authors: James
authors: J
authors: McCracken
authors: James
authors: J
authors: McGough
authors: Stanley F
authors: SF
authors: Nelson
authors: Angela M
authors: AM
authors: Reiersen
authors: Timothy E
authors: TE
authors: Wilens
authors: Janet
authors: J
authors: Wozniak
authors: Benjamin M
authors: BM
authors: Neale
authors: Stephen V
authors: SV
authors: Faraone
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D010552:Personality Assessment; D020641:Polymorphism, Single Nucleotide / Q000235:genetics