[Expression and significance of MTA2 in non-small cell lung cancer].
OBJECTIVE
It has been proven that MTA2 was expressed in many tumor cell lines and was correlated with tumor invasion and metastasis. The aim of this study is to investigate the expression of MTA2 protein in non-small cell lung cancer (NSCLC) and to explore the relationship between the expression of MTA2 and the pathological features.


METHODS
The expression of MTA2 protein in 110 cases of NSCLC and 34 cases corresponding lung tissues was detected with immunohistochemistry method. The relationship between the expression of MTA2 and the pathological features in NSCLC was analyzed statistically.


RESULTS
There was no expression of MTA2 protein in cancer collateral branch trachea epithelial and alveolar epithelial, but there was some expression in partial NSCLC. The positive rate of MTA2 was 58.18% (64/110) in 110 NSCLC cases. The expression of MTA2 had negative correlation with differentiation degree of NSCLC but had positive correlation with clinical stage and lymph node metastasis (P<0.05), moreover, it had no obvious correlation with age, gender and pathological type (P>0.05).


CONCLUSIONS
There was some expression of MTA2 in partial NSCLC and it was correlated with differentiation degree, clinical stage and lymph node metastasis. The results show that the occurrence and development of lung cancer may be related with MTA2. MTA2 may act as a new symbol and target in the treatment of lung cancer.
Wang
Shuhua
S
Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China.
Qi
Yanli
Y
Zhang
Junyi
J
Zhang
Qingfu
Q
Li
Haiying
H
Qiu
Xueshan
X
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism
D012097:Repressor Proteins; C120917:MTA2 protein, human; D006655:Histone Deacetylases