title: Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach.
abstract: We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg/mm(2) (40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM. Reactions are measured over time periods as long as 3 h with high stability.
authors: Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Ontario, Canada, K1A 0R6. Danxia.Xu@Nrc-cnrc.gc.ca
authors: D-X
authors: DX
authors: Xu
authors: M
authors: M
authors: Vachon
authors: A
authors: A
authors: Densmore
authors: R
authors: R
authors: Ma
authors: A
authors: A
authors: Delâge
authors: S
authors: S
authors: Janz
authors: J
authors: J
authors: Lapointe
authors: Y
authors: Y
authors: Li
authors: G
authors: G
authors: Lopinski
authors: D
authors: D
authors: Zhang
authors: Q Y
authors: QY
authors: Liu
authors: P
authors: P
authors: Cheben
authors: J H
authors: JH
authors: Schmid
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D002417:Cattle; D007074:Immunoglobulin G / Q000276:immunology; D055616:Microtechnology; D012710:Serum Albumin, Bovine / Q000032:analysis / Q000276:immunology; D012825:Silicon
chemical_list: D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine; D012825:Silicon