title: Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?
abstract: We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the α-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (≥90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle 'explosive' power of young healthy adults, as assessed during multi-joint exercise tests.
authors: INEF, Universidad Politécnica de Madrid, Madrid, Spain.
authors: Gabriel
authors: G
authors: Rodríguez-Romo
authors: Jonatan R
authors: JR
authors: Ruiz
authors: Catalina
authors: C
authors: Santiago
authors: Carmen
authors: C
authors: Fiuza-Luces
authors: Marta
authors: M
authors: González-Freire
authors: Félix
authors: F
authors: Gómez-Gallego
authors: María
authors: M
authors: Morán
authors: Alejandro
authors: A
authors: Lucia
mesh_terms: D000185:Actinin / Q000235:genetics*; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics / Q000502:physiology; D001120:Arginine / Q000235:genetics; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology; D005080:Exercise Test; D005260:Female; D006801:Humans; D054643:INDEL Mutation / Q000502:physiology; D008297:Male; D053580:Muscle Strength / Q000235:genetics* / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology; D020125:Mutation, Missense / Q000502:physiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D055815:Young Adult
chemical_list: C118456:ACTN3 protein, human; D000185:Actinin; D001120:Arginine; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A