Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus.
Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.
Wu
Xuechen
X
Institute of Protein Research, Tongji University, Shanghai, China.
Shao
Xiaoxia
X
Guo
Zhan-Yun
ZY
Chi
Cheng-Wu
CW
D000595:Amino Acid Sequence; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D052078:Conus Snail / Q000737:chemistry* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D019143:Evolution, Molecular; D006948:Hyperkinesis / Q000503:physiopathology; D007276:Injections, Intraventricular; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D008978:Mollusk Venoms / Q000737:chemistry*; D009478:Neuropeptide Y / Q000235:genetics / Q000302:isolation & purification* / Q000494:pharmacology; D010446:Peptide Fragments / Q000032:analysis*; D017386:Sequence Homology, Amino Acid
D008978:Mollusk Venoms; D009478:Neuropeptide Y; D010446:Peptide Fragments