First synthesis of 3-aryl-4-unsubstituted-6-CF(3)-pyridin-2-ones via aryl migration reaction in the presence of PhI(OAc)(2)/NaOH.
3-Aryl-4-unsubstituted-6-CF(3)-pyridin-2-ones have been efficiently synthesized from readily available 4-aryl-3-carbamoyl-6-CF(3)-pyridin-2(1H)-ones by treatment with PhI(OAc)(2) in the presence of NaOH.
Yi
Hai
H
Department of Chemistry, School of Science, Shanghai University, 99 Shangda Road, Shanghai 200444, PR China.
Song
Liping
L
Wang
Wei
W
Liu
Jianning
J
Zhu
Shizheng
S
Deng
Hongmei
H
Shao
Min
M
D000085:Acetates / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D007462:Iodobenzenes; D011728:Pyridones; C008857:phenyliodosodiacetate; D012972:Sodium Hydroxide