title: Role of serum adiponectin level in the development of liver cirrhosis in patients with hepatitis C virus.
abstract: Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis-C-related liver disease. The aim of our study was to find a relationship between serum adiponectin levels and different grades of steatohepatitis in HCV-infected patients and to correlate it with the severity of liver disease. Sixty HCV-infected patients were divided into two groups according to the presence/absence of steatosis proofed by abdominal ultrasonography and liver biopsy was selected. We evaluated the biochemical parameters for all patients including: ALT, AST, total bilirubin, direct bilirubin, alkaline phosphatase, serum albumin, prothrombin time, CBC, lipid profile, fasting blood glucose, fasting insulin, and serum adiponectin; HOMA-IR was calculated as [fasting insulin (mIU/l) × fasting glucose (mmol/l)]/22.5. We found that adiponectin was significantly lower in HCV-infected patients with steatosis than in those without steatosis. BMI, fasting blood glucose and HOMA-IR were significantly higher in HCV-infected patients with steatosis than in those without steatosis. Furthermore, it was found that steatosis correlates directly with fibrosis index, BMI, HOMA-IR, fasting blood glucose and ALT. Serum adiponectin levels inversely correlates with the grade of steatosis, histological activity index and the stage of fibrosis.
authors: The Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
authors: Hatem Abdel
authors: HA
authors: Latif
authors: Heba S
authors: HS
authors: Assal
authors: Mohamed
authors: M
authors: Mahmoud
authors: Wafaa I
authors: WI
authors: Rasheed
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry; D012720:Severity of Illness Index; D014463:Ultrasonography
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin