Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.
Potent and selective adenosine A(1) receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed.
Griebenow
Nils
N
Bayer Schering Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Building 460, D-42096 Wuppertal, Germany. nils.griebenow@bayerhealthcare.com
Bärfacker
Lars
L
Meier
Heinrich
H
Schneider
Dirk
D
Teusch
Nicole
N
Lustig
Klemens
K
Kast
Raimund
R
Kolkhof
Peter
P
D058916:Adenosine A1 Receptor Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D043682:Receptor, Adenosine A1 / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D058916:Adenosine A1 Receptor Antagonists; D011720:Pyrazoles; D043682:Receptor, Adenosine A1