title: The link between bone and coronary calcifications in CKD-5 patients on haemodialysis.
abstract: BACKGROUND
  Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC).
  
  
  METHODS
  In 207 CKD-5 patients, bone biopsies, multislice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC.
  
  
  RESULTS
  When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained.
  
  
  CONCLUSIONS
  Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.
authors: Division of Nephrology, Department of Radiology and Cardiology, School of Medicine, Ege University, Izmir, Turkey.
authors: Gulay
authors: G
authors: Asci
authors: Ercan
authors: E
authors: Ok
authors: Recep
authors: R
authors: Savas
authors: Mehmet
authors: M
authors: Ozkahya
authors: Soner
authors: S
authors: Duman
authors: Huseyin
authors: H
authors: Toz
authors: Meral
authors: M
authors: Kayikcioglu
authors: Adam J
authors: AJ
authors: Branscum
authors: Marie-Claude
authors: MC
authors: Monier-Faugere
authors: Johann
authors: J
authors: Herberth
authors: Hartmut H
authors: HH
authors: Malluche
mesh_terms: D001847:Bone Diseases / Q000209:etiology*; D016723:Bone Remodeling; D002113:Calcification, Physiologic; D002114:Calcinosis / Q000209:etiology*; D003324:Coronary Artery Disease / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D044342:Malnutrition; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D015996:Survival Rate