Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice.
The identification of transmission routes for bluetongue virus (BTV) is essential to improve the control of the disease. Although BTV is primarily transmitted by several species of Culicoides biting midges, there has been evidence of transplacental and oral transmission. We now report that IFNAR((-/-)) mice are susceptible to oral infection by BTV-8. Viraemia, clinical manifestations and tissue lesions are similar to those in intravenously infected mice. In addition, we show that the oral cavity and oesophagus are susceptible to BTV infection and replication, suggesting that these organs are possible entry routes during BTV oral infection.
Calvo-Pinilla
Eva
E
Centro de Investigación en Sanidad Animal, INIA, 28130 Valdeolmos, Madrid, Spain.
Nieto
José María
JM
Ortego
Javier
J
D000825:Animal Structures / Q000473:pathology / Q000821:virology; D000818:Animals; D001819:Bluetongue / Q000473:pathology* / Q000821:virology*; D001820:Bluetongue virus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D005260:Female; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D008853:Microscopy; D053633:Receptor, Interferon alpha-beta / Q000172:deficiency*; D012756:Sheep; D016019:Survival Analysis; D019562:Viral Load; D014766:Viremia
D053633:Receptor, Interferon alpha-beta