Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis.
Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
Yin
Sheng
S
Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
Boyle
Glen M
GM
Carroll
Anthony R
AR
Kotiw
Michael
M
Dearnaley
John
J
Quinn
Ronald J
RJ
Davis
Rohan A
RA
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D006842:Hydrocarbons, Brominated; D011804:Quinolines; C552991:caelestine A