title: Neurogenic characteristics of placental stem cells in preeclampsia.
abstract: OBJECTIVE
  Preeclampsia is associated with perinatal brain injury. Autologous placenta stem cell transplantation represents a promising future treatment option for neuroregeneration. The aim of this study was to compare the neuroregenerative capacity of preeclampsia-placenta stem cells to previously characterized placentas from uncomplicated pregnancies.
  
  
  METHODS
  Placenta stem cells from amnion (epithelium, mesenchyme) and chorion were assessed for cell surface markers and the formation of neuronal-like cells, oligodendrocytes and their progenitors in culture.
  
  
  RESULTS
  Markers of preeclampsia-placenta stem cells were different from uncomplicated pregnancies-placenta stem cells in amnion epithelium and chorion, but not in amnion mesenchyme. Similarly to uncomplicated pregnancies-placenta stem cells, preeclampsia-placenta stem cells derived from amnion and chorion differentiated preferably into nestin-positive stem/progenitor cells and Tuj-1-positive neurons. However, other important markers were varying after neurogenic differentiation of uncomplicated pregnancies- and preeclampsia-placenta stem cells.
  
  
  CONCLUSIONS
  Surface marker expression patterns of preeclampsia-placenta stem cell's and uncomplicated pregnancies-placenta stem cell's differ. In vitro differentiation assays, however, provide evidence that both preeclampsia-placenta stem cells and uncomplicated pregnancies-placenta stem cells are comparably suitable for neuroregeneration purposes.
authors: Department of Obstetrics and Gynecology, University Hospital, Berne, Switzerland.
authors: C Bettina
authors: CB
authors: Portmann-Lanz
authors: Marc U
authors: MU
authors: Baumann
authors: Martin
authors: M
authors: Mueller
authors: Anna-Margaretha
authors: AM
authors: Wagner
authors: Salome
authors: S
authors: Weiss
authors: Odett
authors: O
authors: Haller
authors: Ruth
authors: R
authors: Sager
authors: Ursula
authors: U
authors: Reinhart
authors: Daniel V
authors: DV
authors: Surbek
mesh_terms: D000650:Amnion / Q000166:cytology; D002454:Cell Differentiation; D002478:Cells, Cultured; D002823:Chorion / Q000166:cytology; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D064231:Nestin; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D010920:Placenta / Q000166:cytology*; D011225:Pre-Eclampsia / Q000473:pathology*; D011247:Pregnancy; D013234:Stem Cells / Q000166:cytology*; D014404:Tubulin / Q000378:metabolism
chemical_list: D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; C498585:TUBB3 protein, human; D014404:Tubulin