title: Selective inhibition of mammalian diamine oxidase by aquatic biotoxins.
abstract: The inhibitory activity of saxitoxin and tetrodotoxin on diamine oxidase and S-adenosyl-l-methionine decarboxylase from mammalian sources have been analysed. Unlike tetrodotoxin, saxitoxin was a reversible non-competitive inhibitor of pig kidney diamine oxidase with an estimated K(i) of 140 mum. S-Adenosyl-l-methionine decarboxylase from a highly purified source was not affected by the concentrations tested of either biotoxin. A possible analytical application of this finding is discussed.
authors: Departamento de Fisiologia, Farmacologia y Toxicologia, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, 24071 León, Spain.
authors: J C
authors: JC
authors: Cubria
authors: R B
authors: RB
authors: Fouce
authors: A
authors: A
authors: Ortiz
authors: M L
authors: ML
authors: Alvarez-Bujidos
authors: D
authors: D
authors: Ordoñez