title: Nanosilver as a new generation of nanoproduct in biomedical applications.
abstract: Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings for wounds and burns. The key to its broad-acting and potent antibacterial activity is the multifaceted mechanism by which NS acts on microbes. This is utilized in antibacterial coatings on medical devices to reduce nosocomial infection rates. Many new synthesis methods have emerged and are being evaluated for NS production for medical applications. NS toxicity is also critically discussed to reflect on potential concerns before widespread application in the medical field.
authors: Centre for Nanotechnology & Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK.
authors: Karla
authors: K
authors: Chaloupka
authors: Yogeshkumar
authors: Y
authors: Malam
authors: Alexander M
authors: AM
authors: Seifalian
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001709:Biotechnology / Q000379:methods; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D012834:Silver / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D012834:Silver