title: Influence of glycemic control on Epstein-Bar and Cytomegalovirus infection in periodontal pocket of type 2 diabetic subjects.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the influence of glycemic control on the frequency of Epstein-Bar (EBV) and Cytomegalovirus (CMV) in periodontal pockets of type 2 diabetic subjects with chronic periodontitis.
  
  
  METHODS
  Forty-six subjects presenting generalized chronic periodontitis and type 2 diabetes mellitus (DM) were selected for this study. Polymerase chain reaction (PCR) was used to determine the presence of EBV and CMV in shallow [Probing Depth (PD)≤3mm], moderate (PD=4-6mm) and deep (PD>7mm) pockets. HbA1c levels ≤7%, >7 to <10%, and ≥10% defined good, moderate and poor glycemic control, respectively.
  
  
  RESULTS
  Higher frequency of EBV was found in the shallow pockets of the subjects with poor glycemic control (p<0.05; chi-square test). Moreover, EBV-free subjects presented moderate or good glycemic control. Glycemic control did not influence the frequency of CMV in all pocket categories.
  
  
  CONCLUSIONS
  Poor glycemic control in type 2 diabetic subjects can increase the occurrence of EBV in shallow periodontal pockets.
authors: Department of Prosthodontics and Periodontics, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors: Renato Corrêa Viana
authors: RC
authors: Casarin
authors: Poliana Mendes
authors: PM
authors: Duarte
authors: Vanessa Renata
authors: VR
authors: Santos
authors: Jadson Almeida
authors: JA
authors: Lima
authors: Guy
authors: G
authors: Gagnon
authors: Márcio Zaffalon
authors: MZ
authors: Casati
authors: Reginaldo Bruno
authors: RB
authors: Gonçalves
mesh_terms: D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000821:virology*; D010518:Periodontitis / Q000821:virology; D016133:Polymerase Chain Reaction; D019562:Viral Load
chemical_list: D001786:Blood Glucose