title: Impact of IgE-mediated hypersensitivity on nasal mucociliary clearance.
abstract: OBJECTIVE
  To evaluate the effect of IgE-mediated hypersensitivity on mucociliary clearance time (MCCT) and clinical severity, as indicated by total nasal symptoms score (TNSS) and peak expiratory flow index (PEFI).
  
  
  METHODS
  A prospective cross-sectional study.
  
  
  METHODS
  Tertiary medical center.
  
  
  METHODS
  One hundred twenty-nine patients with rhinitis and 48 healthy control subjects.
  
  
  METHODS
  Results of an allergy skin prick test in the patients with rhinitis categorized them as allergic (AR) or nonallergic (non-AR). We evaluated TNSS and PEFI in the patient group and assessed MCCTs from the patients in the rhinitis groups and the healthy controls.
  
  
  RESULTS
  The AR group patients had the longest MCCT, followed by patients in the non-AR group and the healthy controls (mean MCCTs, 14.36, 10.87, and 6.55 minutes, respectively). The AR group patients had significantly higher TNSS and worse PEFI compared with patients in the non-AR group (P = .002 and P = .03, respectively). We found a significant positive correlation of MCCTs with TNSS, and MCCTs showed a tendency to be inversely correlated with PEFI (rho = 0.43 [P < .001] and r = -0.22 [P = .05], respectively). In AR group patients, the wheal responses to Dermatophagoides pteronyssinus, Dermatophagoides farinae, American cockroach, and Bermuda grass were fairly correlated with the MCCTs (r = 0.39 [P = .001], r = 0.40 [P = .001], r = 0.34 [P = .01], and r = 0.36 [P = .02], respectively). The maximal wheal response among various positive allergen responses was well correlated with the MCCTs (r = 0.54 [P < .001]).
  
  
  CONCLUSIONS
  A prolonged MCCT, significant correlation between MCCTs and the magnitude of allergen reactivity, and clinical severity suggest an impact of IgE-mediated hypersensitivity on mucociliary clearance function.
authors: Division of Allergy and Rhinology, Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. kvirat2002@yahoo.com
authors: Virat
authors: V
authors: Kirtsreesakul
authors: Pornpanitan
authors: P
authors: Somjareonwattana
authors: Suwalee
authors: S
authors: Ruttanaphol
mesh_terms: D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000276:immunology*; D009298:Nasal Polyps / Q000276:immunology; D010366:Peak Expiratory Flow Rate / Q000276:immunology*; D011446:Prospective Studies; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000276:immunology*; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D000941:Antigens; D007073:Immunoglobulin E