title: Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives.
abstract: A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives.
authors: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-75832, USA.
authors: Anthony R
authors: AR
authors: Prosser
authors: Joseph E
authors: JE
authors: Banning
authors: Marina
authors: M
authors: Rubina
authors: Michael
authors: M
authors: Rubin
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D000577:Amides; D000596:Amino Acids; D017605:Bromine Compounds; D003521:Cyclopropanes