title: [Macroprolactinaemia].
abstract: Hyperprolactinaemia is one of the most common endocrinological disorders affecting the hypothalamic-pituitary axis. The increase of prolactin level in the blood interrupts the pulsatile GnRH secretion and in turn causes hypoestrogenism. Hyperprolactinaemia can occur in physiological and pathological conditions. Prolactin has 3 different isoforms: little prolactin, big prolactin and big-big prolactin. Macroprolactin is a complex of little prolactin and an immunoglobulin G antibody and the weight of the complex is more than 150 kDa. In physiological condition macroprolactin comprises up to 1% of all circulating prolactin in the serum blood. In pathological condition percentage of macroprolactin can increase in the serum blood. The prevalence of macroprolactinaemia is found in around 10-26% of all patients with hyperprolactinaemia. Women with high serum prolactin concentration in should be screened for macroprolactinaemia. Confirmation the presence of macroprolactinaemia doesn't require any pharmacological treatment or other medical procedures.
authors: Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Katedra i Klinika Endokrynologii Ginekologicznej.
authors: Anna
authors: A
authors: Kostrzak
authors: Błazej
authors: B
authors: Meczekalski
mesh_terms: D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008970:Molecular Weight; D011388:Prolactin / Q000097:blood / Q000737:chemistry
chemical_list: D011388:Prolactin