Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex.
The quinpirole sensitization model of obsessive-compulsive disorder was used to investigate the functional role that brain regions implicated in a neuroanatomical circuit of obsessive-compulsive disorder may play in compulsive checking behavior. Following repeated injections of saline or quinpirole (0.5mg/kg, twice per week, ×8 injections) to induce compulsive checking, rats received N-methyl-d-aspartate lesions of the nucleus accumbens core (NAc), orbital frontal cortex (OFC) and basolateral amygdala, or sham lesions. When retested at 17days post-surgery, the results showed effects of NAc and OFC but not basolateral amygdala lesion. NAc lesions affected measures indicative of the amount of checking behavior, whereas OFC lesions affected indices of staying away from checking. The pattern of results suggested that the functional roles of the NAc and OFC in checking behavior are to control the vigor of motor performance and focus on goal-directed activity, respectively. Furthermore, similarities in behavior between quinpirole sham rats and saline NAc lesion rats suggested that quinpirole may drive the vigor of checking by inhibition of NAc neurons, and that the NAc may be a site for the negative feedback control of checking.
Dvorkin
Anna
A
Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Health Science Centre, Room 4N82, Hamilton, ON L8N 3Z5, Canada.
Silva
Charmaine
C
McMurran
Thomas
T
Bisnaire
Liane
L
Foster
Jane
J
Szechtman
Henry
H
D000679:Amygdala / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D003192:Compulsive Behavior / Q000139:chemically induced / Q000503:physiopathology; D004195:Disease Models, Animal; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D009714:Nucleus Accumbens / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced / Q000503:physiopathology; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans
D019257:Quinpirole