title: [Skeletal muscle tissue engineering--current concepts and future perspectives].
abstract: Tissue engineering of skeletal muscle could have great advantages in every clinical setting in need of neurovascular muscle transfer, e. g., facial palsy or Volkmann's contracture. There are 2 great obstacles for the clinical application of engineered muscle tissue at the moment: firstly, finding a three-dimensional matrix that matches the demands concerning biocompatibility, stability and elasticity; secondly, the insufficient differentiation of implanted myoblasts, since myoblast differentiation in vivo is barely controllable and subject to a variety of influences. Furthermore axial vascularisation and neurotisation of such tissue-engineered skeletal muscle constructs play a pivotal role for any later application. An overview of the current status of skeletal muscle tissue engineering technologies and concepts for future perspective in this emerging field is presented in this article.
authors: Universitätsklinikum Erlangen, Plastisch- und Handchirurgische Klinik, Krankenhausstraße 12, Erlangen.
authors: D
authors: D
authors: Klumpp
authors: R E
authors: RE
authors: Horch
authors: F
authors: F
authors: Bitto
authors: A M
authors: AM
authors: Boos
authors: U
authors: U
authors: Kneser
authors: J P
authors: JP
authors: Beier
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D005158:Facial Paralysis / Q000601:surgery; D005544:Forecasting; D048091:Guided Tissue Regeneration / Q000379:methods / Q000639:trends; D006801:Humans; D054061:Ischemic Contracture / Q000601:surgery; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000637:transplantation*; D032446:Myoblasts / Q000166:cytology / Q000637:transplantation; D018919:Neovascularization, Physiologic / Q000502:physiology; D016067:Nerve Transfer / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds