Multiple approaches to enantiopure spirocyclic benzofuranones using organocatalytic cascade reactions.
Three distinct aminocatalytic cascade reactions leading to enantiomerically pure spirocyclic benzofuranones have been devised, highlighting the ability of organocascade to generate high degrees of stereochemical and architectural complexity in a single chemical transformation.
Cassani
Carlo
C
ICIQ-Institute of Chemical Research of Catalonia, Av. Països Catalans 16, 43007 Tarragona, Spain.
Tian
Xu
X
Escudero-Adán
Eduardo C
EC
Melchiorre
Paolo
P
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines; D001572:Benzofurans; D007097:Imines; D013141:Spiro Compounds