Brain immunohistopathological study in a patient with anti-NMDAR encephalitis.
OBJECTIVE
Anti-N-methyl-D-asparate (NMDA) receptor encephalitis is thought to be antibody-mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti-NMDA receptor encephalitis.


METHODS
An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies.


RESULTS
Prominent B-cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma.


CONCLUSIONS
These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.
Camdessanché
J-P
JP
Service de Neurologie, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
Streichenberger
N
N
Cavillon
G
G
Rogemond
V
V
Jousserand
G
G
Honnorat
J
J
Convers
P
P
Antoine
J-C
JC
D000293:Adolescent; D001323:Autoantibodies / Q000009:adverse effects / Q000097:blood; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology* / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002536:Cerebral Arteries / Q000276:immunology / Q000473:pathology; D004660:Encephalitis / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D020293:Vasculitis, Central Nervous System / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate