title: Pulmonary function in children after surgical and percutaneous closure of atrial septal defect.
abstract: This study aimed to study differences in lung function after surgical and percutaneous atrial septal defect (ASD) closure. Several studies have demonstrated abnormalities of pulmonary function in adults and children with ASD. These abnormalities persist even a few years after correction. This study compared pulmonary function between patients who underwent ASD closure by surgery and those who had closure by device. This is the ideal pediatric population for studying changes in lung function caused by cardiopulmonary bypass or sternotomy. The 46 patients in this study were treated by percutaneous closure (group 1) or surgical closure (group 2) of ASD and then scheduled for pulmonary function testing an average of 5.8 years after ASD closure. The mean values of functional residual capacity, total lung capacity, and residual volume did not differ between the two groups. The surgical group showed a significant decrease in expiratory reserve volume (p < 0.04) and forced vital capacity (p < 0.03). Expiratory flow at 25, 50, and 75% of forced vital capacity did not differ between the two groups but was on the lower limit of normal in both groups. Percutaneous closure of ASD can minimize the side effects of surgical closure on lung function. Longitudinal lung function follow-up assessment after cardiac surgery is warranted to detect and measure restrictive abnormalities in this type of congenital heart disease and others.
authors: Department of Pediatric Cardiology, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium.
authors: Mahmoud
authors: M
authors: Zaqout
authors: Frans
authors: F
authors: De Baets
authors: Petra
authors: P
authors: Schelstraete
authors: Bert
authors: B
authors: Suys
authors: Joseph
authors: J
authors: Panzer
authors: Katrien
authors: K
authors: Francois
authors: Thierry
authors: T
authors: Bove
authors: Ilse
authors: I
authors: Coomans
authors: Daniel
authors: D
authors: De Wolf
mesh_terms: D006348:Cardiac Surgical Procedures; D002648:Child; D002675:Child, Preschool; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011183:Postoperative Complications / Q000503:physiopathology*; D012129:Respiratory Function Tests; D018570:Risk Assessment; D018709:Statistics, Nonparametric