title: A case of IgA-related enteropathy complicated with gastrointestinal bleeding and progressive IgA nephropathy: a possible variant Henoch-Schönlein purpura?
abstract: Here, we report an adult patient with IgA-related enteropathy complicated with massive intestinal bleeding and acute renal failure, but without skin lesions. Surgical resection of the small intestine and steroid pulse therapy was performed. Histopathology revealed significant deposition of IgA and C3 in the small vessels of the intestine and the kidney mesangium. Although skin purpura was absent, the histopathology and clinical manifestations suggested that the pathophysiology was similar to Henoch-Schönlein purpura (HSP), implying IgA-related enteropathy as a subclass of HSP. Retrospective analysis indicates that terminal ileum lesions may be a poor prognostic indicator.
authors: The Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors: Shoko
authors: S
authors: Nakamura
authors: Tadakazu
authors: T
authors: Hisamatsu
authors: Jun
authors: J
authors: Kikuchi
authors: Masayuki
authors: M
authors: Adachi
authors: Yoshiyuki
authors: Y
authors: Yamagishi
authors: Hiroyuki
authors: H
authors: Imaeda
authors: Naoki
authors: N
authors: Hosoe
authors: Makoto
authors: M
authors: Naganuma
authors: Hirotoshi
authors: H
authors: Ebinuma
authors: Susumu
authors: S
authors: Okamoto
authors: Takanori
authors: T
authors: Kanai
authors: Haruhiko
authors: H
authors: Ogata
authors: Hironari
authors: H
authors: Hanaoka
authors: Yoshiaki
authors: Y
authors: Furuya
authors: Yoshinaga
authors: Y
authors: Kawano
authors: Kanako
authors: K
authors: Bokuda
authors: Hiroyuki
authors: H
authors: Sasamura
authors: Hiroshi
authors: H
authors: Uchida
authors: Takashi
authors: T
authors: Endo
authors: Akinori
authors: A
authors: Hashiguchi
authors: Kaori
authors: K
authors: Kameyama
authors: Makio
authors: M
authors: Mukai
authors: Toshifumi
authors: T
authors: Hibi
mesh_terms: D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000175:diagnosis*; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis*; D007070:Immunoglobulin A / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D007070:Immunoglobulin A