title: A genome-wide association study of self-rated health.
abstract: Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.
authors: Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Miriam.Mosing@qimir.edu.au
authors: Miriam A
authors: MA
authors: Mosing
authors: Karin J H
authors: KJ
authors: Verweij
authors: Sarah E
authors: SE
authors: Medland
authors: Jodie
authors: J
authors: Painter
authors: Scott D
authors: SD
authors: Gordon
authors: Andrew C
authors: AC
authors: Heath
authors: Pamela A
authors: PA
authors: Madden
authors: Grant W
authors: GW
authors: Montgomery
authors: Nicholas G
authors: NG
authors: Martin
mesh_terms: D000328:Adult; D000368:Aged; D001315:Australia; D005260:Female; D055106:Genome-Wide Association Study; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012647:Self-Assessment