[Expression of vascular endothelial growth factor and microvessel density in hippocampus of rats with aging].
To investigate the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in hippocampus of rats with aging.



Paraffin sections of brain tissue of rats at the age of 3, 18, 24, 30 months were stained by immunohistochemistry, the expression of VEGF and MVD was quantitatively analyzed.



Innunohistochemical staining showed that the VEGF-positive cells were mainly pyramidal neuron in hippocampus; the intensity of VEGF-positivity in neuron cells was decreased with the aging (P<0.05). The MVD in hippocampus was also decreased with the aging of rats (P<0.05).



Increasing VEGF contents and improving blood circulation in brain tissue may prevent or treat vascular dementia and cerebrovascular diseases.
Wu
Hai-qin
HQ
Department of Neurology, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710004, China. whq60@sohu.com
Ren
Bei
B
Sha
Juan-juan
JJ
Wang
Hu-qing
HQ
Zhang
Gui-lian
GL
Li
Ming
M
D000375:Aging; D000818:Animals; D002196:Capillaries / Q000473:pathology; D006624:Hippocampus / Q000098:blood supply* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat