Possible anti-obesity therapeutics from nature--a review.
Obesity is associated with many diseases, particularly diabetes, hypertension, osteoarthritis, and heart disease. The obesity incidence has increased at an alarming rate in recent years, becoming a worldwide health problem, with incalculable social costs. Two different obesity-treatment drugs are currently on the market: orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase; and sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side-effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. These are mainly complex products having several components with different chemical and pharmacological features. This review aimed to survey the literature covering natural products with anti-obesity activity and to review the scientific data, including experimental methodologies, active components, and mechanisms of action against obesity.
Yun
Jong Won
JW
Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, Republic of Korea. jwyun@daegu.ac.kr
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use; D004734:Energy Metabolism; D008049:Lipase / Q000037:antagonists & inhibitors*; D050356:Lipid Metabolism / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy*; D010946:Plants, Medicinal / Q000737:chemistry
D019440:Anti-Obesity Agents; D001067:Appetite Depressants; D001688:Biological Products; D008049:Lipase