Effects of zinc glycine chelate on oxidative stress, contents of trace elements, and intestinal morphology in broilers.
Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1) control (containing 29.3 mg zinc (Zn)/kg basic diet (0-21 days) and 27.8 mg Zn/kg (22-42 days)); (2) basic diet plus 30 mg Zn/kg from Zn-Gly; (3) basic diet plus 60 mg Zn/kg from Zn-Gly; (4) basic diet plus 90 mg Zn/kg from Zn-Gly; (5) basic diet plus 120 mg Zn/kg from Zn-Gly; and (6) positive control, basic diet plus 120 mg Zn/kg from zinc sulfate (ZnSO(4)). The results showed that the addition of 90 or 120 mg/kg Zn-Gly led to an improvement of activity of Cu/Zn superoxide dismutase and glutathione peroxidase and a reduction of malondialdehyde content in livers at 21 and 42 days. With 90 mg/kg Zn-Gly, the content of sera zinc increased by 17.55% (P < 0.05) in 21-day broilers and 10.77% (P > 0.05) in 42-day broilers compared with that of the control. Adding 120 mg/kg Zn-Gly or ZnSO(4) to broilers' diets greatly enhanced the content of zinc in feces at 21 days (P < 0.05) and at 42 days (P < 0.05). For 42-day chickens, increased villus height and decreased crypt depth of the jejunum could be observed in the second growth stage of broilers fed with 90 mg/kg Zn-Gly. Also, intestinal wall thickness decreased (P < 0.05). In addition, adding 90 mg/kg Zn-Gly to the diet markedly elevated villus length of duodenum and decreased crypt depth of ileum (P < 0.05) in 42-day broilers.
Ma
Wenqiang
W
The Key Laboratory of Molecular Animal Nutrition, College of Animal Science, Hua Jia Chi Campus, Zhejiang University, 164 Qiu Tao North Road, 310029 Hangzhou, China.
Niu
Haihua
H
Feng
Jiang
J
Wang
Yong
Y
Feng
Jie
J
D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D002645:Chickens; D019587:Dietary Supplements; D005998:Glycine / Q000737:chemistry / Q000494:pharmacology*; D007422:Intestines / Q000033:anatomy & histology / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
D002614:Chelating Agents; D014131:Trace Elements; D015032:Zinc; D005998:Glycine