Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer.
BACKGROUND
Adult granulosa cell tumor associated with antecedent use of tamoxifen as adjuvant hormonotherapy for breast cancer is rare. The pathogenesis of this occurrence remains difficult to explain. The estrogenic effect of tamoxifen can be one such explanation.


METHODS
A 47 year-old women was treated with surgery, chemotherapy, radiotherapy and tamoxifen for stage III estrogen receptor positive breast carcinoma. Ten months after stopping tamoxifen, we diagnosed a stage Ic granulosa cell tumor of the ovary.


CONCLUSIONS
Use of tamoxifen has been found to be associated with gynecological tumors like endometrial carcinoma. Its association with granulosa cell tumor of the ovary is uncommon. Only two previous cases have been reported in literature.
Abahssain
Halima
H
National institute of oncology, Rabat, Morocco. abahssainhalima@yahoo.fr
Kairouani
Mouna
M
Gherman
Robert
R
M'rabti
Hind
H
Errihani
Hassan
H
D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D011379:Prognosis; D013629:Tamoxifen / Q000009:adverse effects*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen