Synthesis and antifungal activities of some 2,6-bis-(un)substituted phenoxymethylpyridines.
Several 2,6-bis-(un)substituted phenoxymethylpyridines were synthesized and evaluated in vitro against Fusarium graminearum, Helminthosporium sorokinianum, Alternaria brassicae, Alternaria alternata, and Fusarium oxysporum f. sp. vasinfectum. Among all derivatives, compound 3a exhibited a broad-spectrum antifungal activity against the five phytopathogenic fungi.
Xu
Hui
H
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A & F University, Yangling 712100, PR China. orgxuhui@nwsuaf.edu.cn
Qu
Huan
H
D000528:Alternaria / Q000187:drug effects; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects; D006375:Helminthosporium / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D011725:Pyridines