title: Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction.
abstract: Doxorubicin (ADRIAMYCIN, RUBEX) is a chemotherapeutic agent that is commonly administered to breast cancer patients in standard chemotherapy regimens. As true of all such therapeutic cytotoxic agents, it can damage normal, noncancerous cells and might affect biochemical processes in a manner that might lead to, or contribute to, chemotherapy-induced cognitive deficits when administered either alone or in combination with other agents.
authors.affiliation: University of Kentucky, Lexington 40506-0055, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Aluise
authors.forename: Rukhsana
authors.initials: R
authors.lastname: Sultana
authors.forename: Jitbangjong
authors.initials: J
authors.lastname: Tangpong
authors.forename: Mary
authors.initials: M
authors.lastname: Vore
authors.forename: Daret
authors.initials: D
authors.lastname: St Clair
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Moscow
authors.forename: D Allan
authors.initials: DA
authors.lastname: Butterfield
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D015538:Nitrosation; D018384:Oxidative Stress
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D004317:Doxorubicin