[Pinch-induced catalepsy in rats of various genetic groups with different predisposition to audiogenic epilepsy].
Proportion of animals which developed pinch-induced catalepsy and the duration of this state were analyzed in rats of several genotypes which differed in audiogenic epilepsy proneness and compared with "audiogenic" catalepsy after a sound-induced seizure fit. The following genotypes were studied: Wistar, KM (Krushinsky-Molodkina) strain and substrains "4" and "0" (selected from KM and Wistar hybrid population for high "4" and low "0" audiogenic epilepsy proneness). Adult KM and substrain "4" rats developed the most intense pinch induced catalepsy, whereas Wistar and 2-month-old KM showed practically no catalepsy. After a single sound exposure pinch-induced catalepsy developed in all animals which demonstrated an audiogenic seizure fit--in KM, substrain "4", part of Wistar rats and several animals of substrain "0", latency of the fit onset in all rats being shorter than initially. After sound exposure pinch-induced catalepsy was revealed even in those substrain "0" rats, which demonstrated no audiogenic fits. It is suggested that despite the phenomenological similarity between cataleptic states of different origin (pinch-induced, "audiogenic") their neurophysiologic substrates overlap only partially. The findings are considered as presenting genetic model for further analysis of catalepsy.
Surina
N M
NM
Fedotova
I B
IB
Kulikov
A V
AV
Poletaeva
I I
II
D000818:Animals; D002375:Catalepsy / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D020195:Epilepsy, Reflex / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013045:Species Specificity