title: Coumarins from Seseli hartvigii.
abstract: Linear-type furocoumarins, 5-[(2"E,6"R)-6"-hydroxy-3",7"-dimethylocta-2",7"-dienyloxy]psoralen and 5-[(2"E,6"S)-6"-hydroxy-3",7"-dimethylocta-2",7"-dienyloxy]psoralen (1) were first isolated from whole plants of Seseli hartvigii together with one new natural product 6-(3'-methyl-2'-oxo-3'-butenyl)-7-methoxycoumarin (2), and four known compounds (tamarin, bergaptol, notoptol, and a mixture of beta-sitosterol and stigmasterol). The structure of 1 was elucidated by extensive spectroscopic analysis and chemical conversion. The modified Mosher's method and HPLC were applied to determine its stereochemistry. Both R- and S-configurations exist in 1; after modification by Mosher's reagent, they were effectively separated, and their ratio was deduced to be 59% and 41%, respectively.
authors.affiliation: Shenyang Pharmaceutical University, Department of Traditional Medicine, 110000 Liaoning-Shenyang, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Alev
authors.initials: A
authors.lastname: Tosun
authors.forename: Masaki
authors.initials: M
authors.lastname: Baba
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Okada
authors.forename: Lijun
authors.initials: L
authors.lastname: Wu
authors.forename: Torn
authors.initials: T
authors.lastname: Okuyama
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003374:Coumarins