title: Contemporary management of sinonasal cancer.
abstract: BACKGROUND
  Sinonasal cancer is a relatively uncommon entity encountered by head and neck oncologists, rhinologists, and skull base surgeons. Recent innovations in surgical and nonsurgical therapeutic modalities raise the question of whether there has been any measurable improvement for treatment outcomes.
  
  
  METHODS
  A retrospective review of data from recent studies that focus on surgery, radiation, and chemotherapy, or combinations thereof, was conducted.
  
  
  RESULTS
  Surgery continues to be the preferred treatment and provides the best results, albeit with an inherent bias based on patient selection. For advanced disease (T4 lesions), the survival rate remains only modest. Complications of treatment, including both surgical and radiation therapy, have been reduced.
  
  
  CONCLUSIONS
  There is a need to improve the efficacy of treatment for this disease. Recommendations for the future direction of therapeutic investigations are outlined.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
authors.forename: K Thomas
authors.initials: KT
authors.lastname: Robbins
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
authors.forename: Carl E
authors.initials: CE
authors.lastname: Silver
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.forename: Primoz
authors.initials: P
authors.lastname: Strojan
authors.forename: Carl H
authors.initials: CH
authors.lastname: Snyderman
authors.forename: Remco
authors.initials: R
authors.lastname: de Bree
authors.forename: Missak
authors.initials: M
authors.lastname: Haigentz
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Langendijk
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Shaha
authors.forename: Ehab Y
authors.initials: EY
authors.lastname: Hanna
authors.forename: Jochen A
authors.initials: JA
authors.lastname: Werner
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004724:Endoscopy; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D008198:Lymph Nodes / Q000528:radiation effects; D008207:Lymphatic Metastasis; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000628:therapy*; D010255:Paranasal Sinus Neoplasms / Q000628:therapy*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011788:Quality of Life; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor