title: Lung cancer associated with beta-carotene supplementation in smokers.
abstract: A meta-analysis of four randomised trials in a total of 109 394 subjects showed a statistically significant increase in the risk of lung cancer among smokers who used dietary supplements containing beta-carotene, at a mean dose of 20 to 30 mg/day. This contradicts the results of observational studies conducted in the 1990s.
mesh_terms: D019587:Dietary Supplements; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D012907:Smoking / Q000009:adverse effects*; D019207:beta Carotene / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D019207:beta Carotene