Triterpene saponins from Cyclamen persicum.
A new triterpene saponin 3-O-beta-D-glucopyranosyl-(1 --> 4)-alpha-L-arabinopyranosyl-16alpha-hydroxy-13beta,28-epoxy-oleanan-30-al (1), along with four known triterpene glycosides (2-5) were isolated from Cyclamen persicum. Their structures were characterized by a combination of 1D- and 2D-NMR (1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and MS spectrocopic data. The cytotoxicity of compounds 2 and 4 was evaluated using two human colon cancer cell lines HT-29 and HCT 116.
Mihci-Gaidi
Ghezala
G
Laboratoire de Pharmacognosie, Unité de Molécules d'Intérĉt Biologique (UMIB UPRES EA 3660), Faculté de Pharmacie, Universitá de Bourgogne, BP 87900, 21079 Dijon Cedex, France.
Pertuit
David
D
Miyamoto
Tomofumi
T
Mirjolet
Jean-François
JF
Duchamp
Olivier
O
Mitaine-Offer
Anne-Claire
AC
Lacaille-Dubois
Marie-Aleth
MA
D045744:Cell Line, Tumor; D031824:Cyclamen / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000633:toxicity*; D014315:Triterpenes / Q000737:chemistry*
D012503:Saponins; D014315:Triterpenes