Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.
BACKGROUND
Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD.


METHODS
We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD patients without suicide. Differences in behavioral and personality traits according to genotypic variation were investigated by logistic regression analysis.


RESULTS
There were no significant differences between MDD patients with suicide and controls in genotypic (AG and GG) frequencies for rs7305115 SNP, but the distribution of AA genotype differed significantly (14.4% vs. 29.3%, p < 0.001). The G-allele frequency was significantly higher in cases than control group (58.1% vs.45.6%, p < 0.001), but the A-allele carrier indicated a decreased trend in MDD with suicide behaviors than control group (41.9% vs.54.4%, p < 0.001). The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients.


CONCLUSIONS
The study suggested that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in MDD while the TPH2 rs7305115A remained a significant protective predictor of suicide attempts.
Zhang
Yuqi
Y
Wuxi Psychiatric Hospital, Nanjing Medical University, Wuxi, China. hbzcs@126.com
Zhang
Changsong
C
Yuan
Guozhen
G
Yao
Jianjun
J
Cheng
Zaohuo
Z
Liu
Chaojun
C
Liu
Qinghai
Q
Wan
Gairong
G
Shi
Guizhi
G
Cheng
Yiren
Y
Ling
Yang
Y
Li
Ke
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D003865:Major Depressive Disorder / Q000150:complications / Q000235:genetics*; D004644:Emotions; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase