Prophylactic treatment for hypertension and seizure in a case of allogeneic hematopoietic stem cell transplantation after posterior reversible encephalopathy syndrome.
A six-yr-old boy developed PRES after induction chemotherapy for the relapse of acute lymphoblastic leukemia. Two months after PRES, he underwent BMT from an unrelated HLA-mismatched donor. There were many risk factors for PRES in the BMT including the long-term use of FK506 and methylprednisolone, grade III graft-versus-host disease, thrombotic microangiopathy, and sepsis. Prophylactic treatment for hypertension with nicardipine in conjunction with close monitoring of the magnesium level and the use of valproic acid might be an effective management approach to prevent post-transplant PRES.
Fukuyama
Tetsuhiro
T
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. fukuyama@shinshu-u.ac.jp
Tanaka
Miyuki
M
Nakazawa
Yozo
Y
Motoki
Noriko
N
Inaba
Yuji
Y
Higuchi
Tsukasa
T
Koike
Kenichi
K
D000927:Anticonvulsants / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D008279:Magnetic Resonance Imaging; D008297:Male; D054038:Posterior Leukoencephalopathy Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D011859:Radiography; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014184:Transplantation, Homologous; D061349:Unrelated Donors
D000927:Anticonvulsants; D000959:Antihypertensive Agents