title: Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals.
abstract: In mice, rabbits, and pigs, two basic types of cardiac myosin isoenzymes were found by electrophoresis of native molecules: a fast-migrating form with high Ca(2+)-dependent ATPase activity and a slow-migrating form with low activity. According to the nomenclature of J. F. Y. Hoh, P. A. McGrath, and P. T. Hale (1978, J. Mol. Cell. Cardiol. 10, 1053-1076) these forms are called, respectively, V1 and V3. In all species, myosin was essentially V3 during fetal life, while V1 appeared around the time of birth. There were species differences in adults: mice remained V1, while rabbits and pigs returned to V3 after 3 weeks of age. Adult dog, beef, and human myosins were also composed of the V3 form only.
authors.affiliation: U 127 INSERM Hopital Lariboisière, 41 Bd de La Chapelle, 75010 Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Lompre
authors.forename: J J
authors.initials: JJ
authors.lastname: Mercadier
authors.forename: C
authors.initials: C
authors.lastname: Wisnewsky
authors.forename: P
authors.initials: P
authors.lastname: Bouveret
authors.forename: C
authors.initials: C
authors.lastname: Pantaloni
authors.forename: A
authors.initials: A
authors.lastname: D'Albis
authors.forename: K
authors.initials: K
authors.lastname: Schwartz
mesh_terms: D000367:Age Factors; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000032:analysis; D002417:Cattle; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D051379:Mice; D032383:Myocytes, Cardiac / Q000201:enzymology*; D009218:Myosins / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine
chemical_list: D007527:Isoenzymes; D009218:Myosins; D000252:Calcium-Transporting ATPases