title: Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps.
abstract: The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.
authors.affiliation: Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Hariharan
authors.forename: Martin
authors.initials: M
authors.lastname: McCullagh
authors.forename: George C
authors.initials: GC
authors.lastname: Schatz
authors.forename: Frederick D
authors.initials: FD
authors.lastname: Lewis
mesh_terms: D004277:DNA, Single-Stranded / Q000737:chemistry*; D019281:Dimerization; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D055668:Photochemical Processes; D013941:Thymine / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded; D009841:Oligonucleotides; C477371:locked nucleic acid; D013941:Thymine