Identification of low circulatory transforming growth factor beta-1 in patients with degenerative heart valve disease.
Transforming growth factor β-1 (TGF-β1) is an immunosuppressive cytokine. It exerts cardioprotection during acute myocardial ischaemia, promoting healing of the injured myocytes. Lower plasma concentrations of TGF-β1 have been identified in patients with coronary artery disease (CAD) compared to those with normal coronary arteries. We measured plasma TGF-β1 concentrations in patients with CAD compared to those with degenerative heart valves (DHVs) and normal coronary arteries. The mean concentration of TGF-β1 in patients with valvular heart disease was significantly lower (18.67 μg/l) than the mean in the coronary artery bypass graft (CABG) group (26.46 μg/l). There was no correlation between the patient characteristics and preoperative concentration of TGF-β1. It is possible that the lower plasma concentration of TGF-β1 in patients with valvular heart disease and the lack of its regulatory effect results in the increased inflammation and calcification seen in DHVs.
Attaran
Saina
S
Department of Cardiothoracic Surgery, King's College Hospital, London SE9 5RS, UK. saina.attaran@kcl.ac.uk
Sherwood
Roy
R
Dastidar
Michael Ghosh
MG
El-Gamel
Ahmed
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood* / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000097:blood*
D015415:Biomarkers; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1