title: Aptasensors: a review.
abstract: Aptamers are a promising class of agents for biomolecules detection due to their small size, chemical stability and cost effectiveness over conventional bioreceptors such as antibodies. Recent advances in micro/nano-fabrication and biotechnology have driven active participation of engineers and molecular biologists in the development of aptasensors. This review examines aptasensors from a developer standpoint discussing surface immobilization techniques and mechanisms used to detect biomolecular interactions in the context of biotechnology and nanomedicine. The factors that affect accuracy, sensitivity and stability of aptasensors are also addressed.
authors.affiliation: School of Engineering, Deakin University, Victoria 3217, Australia.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lim
authors.forename: A Z
authors.initials: AZ
authors.lastname: Kouzani
authors.forename: W
authors.initials: W
authors.lastname: Duan
mesh_terms: D052157:Aptamers, Nucleotide; D015374:Biosensing Techniques; D055598:Chemical Phenomena; D006046:Gold; D006801:Humans; D037742:Nanotubes, Carbon; D020349:Surface Plasmon Resonance; D013499:Surface Properties; D014159:Transducers
chemical_list: D052157:Aptamers, Nucleotide; D037742:Nanotubes, Carbon; D006046:Gold