A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children.
Our objective was to compare the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Forty children aged 1-11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts to an 8-week course of ultramicronized griseofulvin dosed at 10-12 mg/kg/day. At weeks 2, 4, and 8, subjects returned to the clinic for evaluation and scalp cultures. Subjects then returned for follow-up visits 4 weeks after completing treatment. Overall, by 8 weeks, 30 of 33 (90.9%) treated children demonstrated mycological cure. Selenium sulfide shampoo 1% and ciclopirox shampoo 1% were equally effective as adjunctive treatments for tinea capitis in children in our study.
Chen
Catherine
C
Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Koch
Laine H
LH
Dice
James E
JE
Dempsey
Kimberly K
KK
Moskowitz
Alan B
AB
Barnes-Eley
Myra L
ML
Hubbard
Thomas W
TW
Williams
Judith V
JV
D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D000077768:Ciclopirox; D004311:Double-Blind Method; D005260:Female; D006203:Hair Preparations / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011728:Pyridones / Q000627:therapeutic use*; D018036:Selenium Compounds / Q000627:therapeutic use*; D014006:Tinea Capitis / Q000188:drug therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents; D006203:Hair Preparations; D011728:Pyridones; D018036:Selenium Compounds; D000077768:Ciclopirox; C025698:selenium disulfide