Complete surface control of peptide nanospheres with detachable and attachable polymer brush layers.
The surfaces of biodegradable peptide nanospheres with density-controllable poly(ethylene glycol) (PEG) brush layers were amenable to high levels of control, from hydrophilic 'stealth' properties to hydrophobic adsorptive properties depending on the PEG density in response to environmental conditions -'intelligent' properties that are expected to be useful for novel drug delivery systems.
Waku
Tomonori
T
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita 565-0871, Japan.
Matsumoto
Masahiro
M
Matsusaki
Michiya
M
Akashi
Mitsuru
M
D000818:Animals; D004912:Erythrocytes / Q000737:chemistry; D008958:Models, Molecular; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012756:Sheep; D013499:Surface Properties
D010455:Peptides; D011092:Polyethylene Glycols