Resveratrol oligomers from Vatica albiramis.
Five new stilbenoids, vatalbinosides A-E (1-5), and 13 known compounds (6-18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (-)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.
Abe
Naohito
N
Laboratory of Pharmacognosy, Gifu Pharmaceutical University, Gifu Gifu 501-1196, Japan.
Ito
Tetsuro
T
Ohguchi
Kenji
K
Nasu
Minori
M
Masuda
Yuichi
Y
Oyama
Masayoshi
M
Nozawa
Yoshinori
Y
Ito
Masafumi
M
Iinuma
Munekazu
M
D053958:Dipterocarpaceae / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D053583:Interleukin-1beta / Q000187:drug effects*; D008296:Malaysia; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis* / Q000187:drug effects; D015394:Molecular Structure; D010636:Phenols; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D000077185:Resveratrol; D012867:Skin / Q000166:cytology / Q000187:drug effects; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D053583:Interleukin-1beta; D010636:Phenols; D013267:Stilbenes; C518233:hopeaphenol; C459559:vaticanol C; D020781:Matrix Metalloproteinase 1; D000077185:Resveratrol