title: Basic science of intra-articular fractures and posttraumatic osteoarthritis.
abstract: Intra-articular fractures represent the primary etiologic factor leading to posttraumatic osteoarthritis. The pathomechanisms linking intra-articular fractures to end-stage cartilage destruction are poorly understood. However, fracture-related chondrocyte death has been linked to posttraumatic osteoarthritis. Researchers have made significant progress in understanding the pathomechanical link between injury and chondrocyte death. This article reviews recent basic scientific progress investigating intraarticular fractures and fracture-related chondrocyte death and dysfunction.
authors.affiliation: Department of Orthopaedic Surgery, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA. Todd-mckinley@uiowa.edu
authors.forename: Todd O
authors.initials: TO
authors.lastname: McKinley
authors.forename: Joseph
authors.initials: J
authors.lastname: Borrelli
authors.forename: Darryl D
authors.initials: DD
authors.lastname: D'Lima
authors.forename: Bridgette D
authors.initials: BD
authors.lastname: Furman
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
mesh_terms: D000367:Age Factors; D000818:Animals; D017209:Apoptosis; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology; D002417:Cattle; D019902:Chondrocytes / Q000473:pathology; D004195:Disease Models, Animal; D050724:Fractures, Cartilage / Q000150:complications* / Q000473:pathology; D006801:Humans; D057072:Intra-Articular Fractures / Q000150:complications* / Q000473:pathology; D010003:Osteoarthritis / Q000209:etiology* / Q000473:pathology