[Endothelial dysfunction in urolithiasis patients].
To characterize endothelial dysfunction in operated nephrolithiasis patients, we studied NO, VEGF, ET-1, IL-6 concentration in the blood serum and NO in the urine of nephrolithiasis patients divided into three groups by the type of surgical treatment before operation, 7-10 days and 1 month after it. We used beta-2 microglobulin as an indicator of tubular dysfunction. We found a significant rise of a concentration of the endothelial dysfunction markers ET-1, IL-6 and VEGF in the blood serum (p < 0.05), showing endothelial dysfunction in nephrolithiasis patients, especially in early postoperative period after multiple exposure to short-wave lithotripsy. One month after open surgery or lithotripsy a complete recovery of endothelial function was not recorded.
Glybochko
P V
PV
Svistunov
A A
AA
Rossolovskiĭ
A N
AN
Ponukalin
A N
AN
Zakharova
N B
NB
Bliumberg
B I
BI
Berezinets
O L
OL
D000328:Adult; D019332:Endothelin-1 / Q000097:blood*; D004727:Endothelium / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood* / Q000652:urine; D013997:Time Factors; D052878:Urolithiasis / Q000097:blood* / Q000601:surgery / Q000652:urine; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D019332:Endothelin-1; C508600:IL6 protein, human; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D009569:Nitric Oxide