title: Aspirin desensitization/challenge in 3 patients with unstable angina.
abstract: Aspirin sensitivity is relatively frequent and can be a major problem in patients who need percutaneous coronary intervention and stenting with subsequent dual antiplatelet therapy. Desensitization is often the therapy in these patients, but this can prolong the time to revascularization significantly. Rapid oral aspirin desensitization protocols have been described since 2000. However, data are lacking on the optimal strategy for aspirin desensitization and determining which patients are mostly benefited from this desensitization. The authors describe the use of a Wong-modified protocol in 3 patients who had known aspirin sensitivity and who had unstable angina and an indication for percutaneous coronary intervention.
authors.affiliation: Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA. aortegaloayza2@mcvh-vcu.edu
authors.forename: Alex G
authors.initials: AG
authors.lastname: Ortega-Loayza
authors.forename: Syed
authors.initials: S
authors.lastname: Raza
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Minisi
authors.forename: On
authors.initials: O
authors.lastname: Topaz
authors.forename: Andrew
authors.initials: A
authors.lastname: Heller
authors.forename: Ion S
authors.initials: IS
authors.lastname: Jovin
mesh_terms: D000789:Angina, Unstable / Q000188:drug therapy*; D001241:Aspirin / Q000276:immunology* / Q000627:therapeutic use*; D003888:Desensitization, Immunologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000276:immunology* / Q000627:therapeutic use*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin