K+(ATP) channels-independent analgesic action of Crotalus durissus cumanensis venom.
The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 microg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 microg/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinociceptive mechanism of CDCM.
Pereira
Ticiana Praciano
TP
Department of Pharmacy, Federal University of Ceara, Fortaleza, Ceara, Brazil.
Campos
Adriana Rolim
AR
Leal
Luzia Kalyne A M
LK
Pierdoná
Taiana Magalhães
TM
Toyama
Marcos H
MH
Monteiro
Helena Serra Azul
HS
Martins
Alice Maria Costa
AM
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D017839:Crotalus / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology; D054086:KATP Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D012910:Snake Venoms / Q000627:therapeutic use*
D000700:Analgesics; D054086:KATP Channels; D026902:Potassium Channel Blockers; D012910:Snake Venoms; D005905:Glyburide