Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus.
We describe the first reported case of a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by low-dose tacrolimus in a patient with autoimmune disease. A 41-year-old man with systemic lupus erythematosus (SLE) developed hyponatremia induced by SIADH after administration of tacrolimus (0.06 mg/kg per day). In this case, the hyponatremia promptly resolved upon withdrawal of tacrolimus. This case strongly suggests that SIADH is a potentially important complication of tacrolimus administration, irrespective of dosage, and should be borne in mind whenever the drug is used.
Suemori
Koichiro
K
Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan. suemori@m.ehime-u.ac.jp
Hasegawa
Hitoshi
H
Nanba
Chika
C
Kohno
Masashi
M
Matsumoto
Takuya
T
Kawamoto
Yusuke
Y
Murakami
Shinji
S
Sada
Eiji
E
Hashimoto
Koji
K
Yasukawa
Masaki
M
D000328:Adult; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008297:Male; D016559:Tacrolimus / Q000009:adverse effects*; D028761:Withholding Treatment
D007166:Immunosuppressive Agents; D016559:Tacrolimus