Aziridinomitosanes via lactam cyclization.
Aziridinomitosane ketones 4 and 24 are accessed by internal acyl anion equivalent-lactam cyclization of 29 in a convergent route. The key aziridinolactam 6 is prepared by tin-lithium exchange via the lithiated aziridine 11.
Wiedner
Susan D
SD
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.
Vedejs
Edwin
E
D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008937:Mitomycins / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D001388:Aziridines; D008937:Mitomycins; C435767:mitosane; C033132:aziridine