Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.
Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.
Taylor
Stephen
S
Department of Sexual Health and HIV Medicine, Directorate of Infection, Birmingham Heartlands Hospital, Birmingham, UK.
Jayasuriya
Ashini N
AN
Berry
Amanda
A
Gilleran
Gerry
G
Dufty
Ngozi E
NE
Else
Laura
L
Back
David J
DJ
Smit
Erasmus J
EJ
D000328:Adult; D019380:Anti-HIV Agents / Q000378:metabolism*; D000069454:Darunavir; D004352:Drug Resistance, Microbial; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000821:virology*; D013449:Sulfonamides / Q000378:metabolism*
D019380:Anti-HIV Agents; D013449:Sulfonamides; D000069454:Darunavir