Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development.
We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women.
Rhee
Jee Eun
JE
Division of AIDS, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Korea.
Shin
Mi Yeong
MY
Kim
Choong Mo
CM
Kee
Hye Young
HY
Chung
Jae Keun
JK
Min
Sang-Kee
SK
Kim
Seong-Joon
SJ
Jang
Dai-Ho
DH
Kim
Sung Soon
SS
Choi
Byeong-Sun
BS
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D053918:Papillomavirus Vaccines / Q000276:immunology; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control; D055815:Young Adult
D004279:DNA, Viral; D053918:Papillomavirus Vaccines