Clinically effective CK-MB reporting: how to do it?
The clinical utility of measuring the Muscle Brain (MB) isoenzyme of creatine kinase (CK) in the diagnosis of myocardial injury is well established. CK/CK-MB measurement in combination or CK-MB alone is widely used and reporting the results of CK-MB in absolute unit is the common current practice. CK-MB is widely measured by "Immunoinhibition" in India, which gives falsely elevated CK-MB results in the following circumstances: Central nervous system damage, childbirth, macro CK-immunoglobulin complex, in patients with carcinoma of various organs, such as prostate carcinoma and other adenocarcinomas. But, reporting %CK-MB rather than the absolute CK-MB results assists in detection of macroCK (or CK variants), associated proliferative and autoimmune pathologies and their prognosis.
Vivekanandan
S
S
Department of Clinical Biochemistry, Global Hospitals & Health City, Chennai, India. sachidanandamv@yahoo.co.uk
Swaminathan
R
R
D052279:Creatine Kinase, MB Form / Q000097:blood*; D005189:False Positive Reactions; D006801:Humans; D007124:Immunoenzyme Techniques; D007194:India; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000201:enzymology; D011379:Prognosis
D007527:Isoenzymes; D052279:Creatine Kinase, MB Form