title: Thyroxine suppression therapy for benign, non-functioning solitary thyroid nodules: a quality-effects meta-analysis.
abstract: Levothyroxine (LT4) suppressive therapy for solitary thyroid nodules is not popularly advocated presently because its clinical efficacy and safety are currently considered controversial. This meta-analysis aims to address efficacy issues by using rigorous methods to arrive at a pooled estimate. On the basis of the analysis, it is estimated that LT4 therapy is clearly associated with up to a two-fold increase in the chance of nodule reduction. This translates to a number needed to treat (NNT) of 6 or a 50% decrease in the risk of cancer given nodule reduction. Keeping this definition of efficacy in mind and a low incidence of adverse events with low level LT4 suppression, such an intervention might be appropriate in patients selected on the basis of a low risk for adverse effects.
authors.affiliation: Department of Medicine, Mubarak Al-Kabeer Teaching Hospital, Kuwait.
authors.forename: Altayyeb
authors.initials: A
authors.lastname: Yousef
authors.forename: Justin
authors.initials: J
authors.lastname: Clark
authors.forename: Suhail A R
authors.initials: SA
authors.lastname: Doi
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D012074:Remission Induction; D012307:Risk Factors; D016606:Thyroid Nodule / Q000401:mortality / Q000628:therapy*; D013974:Thyroxine / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D013974:Thyroxine