Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders.
The cerebral cortex has a central role in cognitive and emotional processing. As such, understanding the mechanisms that govern its development and function will be central to understanding the bases of severe neuropsychiatric disorders, particularly those that first appear in childhood. In this review, I highlight recent progress in elucidating genetic, molecular and cellular mechanisms that control cortical development. I discuss basic aspects of cortical developmental anatomy, and mechanisms that regulate cortical size and area formation, with an emphasis on the roles of fibroblast growth factor (Fgf) signaling and specific transcription factors. I then examine how specific types of cortical excitatory projection neurons are generated, and how their axons grow along stereotyped pathways to their targets. Next, I address how cortical inhibitory (GABAergic) neurons are generated, and point out the role of these cells in controlling cortical plasticity and critical periods. The paper concludes with an examination of four possible developmental mechanisms that could contribute to some forms of neurodevelopmental disorders, such as autism.
Rubenstein
John L R
JL
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94158-2324, USA. john.rubenstein@ucsf.edu
D000342:Affective Symptoms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001321:Autistic Disorder / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D001369:Axons / Q000473:pathology / Q000502:physiology; D019521:Body Patterning / Q000235:genetics / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D054081:Malformations of Cortical Development, Group II / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D009433:Neural Inhibition / Q000235:genetics / Q000502:physiology; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D011247:Pregnancy; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000502:physiology
C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; D005680:gamma-Aminobutyric Acid; D005346:Fibroblast Growth Factors