Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma.
We present a unique case of bilateral gonadoblastoma in a 23-year-old patient with Swyer syndrome. The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one. The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion. Most probably, the pathogenesis of this abdominal dissemination was iatrogenic, with implantation occurring mechanically as a result of the multiple laparoscopic biopsies performed on both of the streak gonads 2 months before the abdominal surgery. The pathogenesis of other benign abdominal implants is discussed.
Onida
Giovanna A
GA
Department of Pathology and Obstetrics and Gynecology, Università degli Studi di Sassari, Sardinia, Italy.
Bosincu
Luisanna
L
Dessole
Salvatore
S
Nicolae
Alina
A
Preda
Ovidiu
O
Cossu-Rocca
Paolo
P
Aneiros-Fernandez
Jose
J
Nogales
Francisco F
FF
D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications / Q000473:pathology; D018238:Gonadoblastoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology*; D010537:Peritoneum / Q000473:pathology; D012707:Sertoli Cell Tumor / Q000150:complications / Q000473:pathology*; D014565:Urogenital Neoplasms / Q000150:complications / Q000473:pathology*; D055815:Young Adult