title: Probabilistic muscle characterization using quantitative electromyography: application to facioscapulohumeral muscular dystrophy.
abstract: Based on quantitative electromyography, a muscle can be categorized as normal or affected by a neuromuscular disorder. The objective of this work was to compare the utility of probabilistic to conventional means and outlier methods of categorization of myopathic and normal muscles. Various sets of motor unit potential (MUP) features detected in biceps brachii muscles of control subjects and patients with facioscapulohumeral muscular dystrophy were used to categorize them as normal or myopathic based on conventional means and outlier categorization (CMC) as well as a new probabilistic muscle categorization (PMC). The sensitivity, specificity, and accuracy provided by each categorization method were compared. The categorizations made using PMC were significantly more accurate (by at least 10%) compared with CMC (P < 10(-10)) for muscles evaluated in this study. Area, duration, and thickness were highly discriminative MUP features.
authors.affiliation: Department of Epidemiology and Biostatistics, University of Western Ontario, 339 Windermere Road, London, Ontario N6A 5A5, Canada. lpino@uwo.ca
authors.forename: Lou Joseph
authors.initials: LJ
authors.lastname: Pino
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Stashuk
authors.forename: Simon
authors.initials: S
authors.lastname: Podnar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001132:Arm; D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D018482:Muscle, Skeletal / Q000503:physiopathology*; D020391:Muscular Dystrophy, Facioscapulohumeral / Q000175:diagnosis / Q000503:physiopathology*; D011336:Probability; D012680:Sensitivity and Specificity; D055815:Young Adult