Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction.
Doxorubicin (ADRIAMYCIN, RUBEX) is a chemotherapeutic agent that is commonly administered to breast cancer patients in standard chemotherapy regimens. As true of all such therapeutic cytotoxic agents, it can damage normal, noncancerous cells and might affect biochemical processes in a manner that might lead to, or contribute to, chemotherapy-induced cognitive deficits when administered either alone or in combination with other agents.
Aluise
Christopher D
CD
University of Kentucky, Lexington 40506-0055, USA.
Sultana
Rukhsana
R
Tangpong
Jitbangjong
J
Vore
Mary
M
St Clair
Daret
D
Moscow
Jeffrey A
JA
Butterfield
D Allan
DA
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D015538:Nitrosation; D018384:Oxidative Stress
D000970:Antineoplastic Agents; D016207:Cytokines; D004317:Doxorubicin