title: 1,5-Anhydroglucitol levels are low irrespective of plasma glucose levels in patients with chronic liver disease.
abstract: BACKGROUND
  Serum 1,5-anhydroglucitol (1,5-AG) is a known marker reflecting recent glycaemic control. In this study, we examined serum 1,5-AG levels in chronic liver disease (CLD) patients with and without diabetes mellitus.
  
  
  METHODS
  Eighty patients with CLD were compared with 667 subjects without CLD. Glycaemic control of the CLD patients was evaluated by estimated glycated haemoglobin (HbA(1C)) calculated using the equation by Rohlfing et al. from mean plasma glucose because CLD patients have apparently low HbA(1C).
  
  
  RESULTS
  When the study participants were divided into subgroups stratified by HbA(1C) levels, the CLD patients whose estimated HbA(1C) levels were less than 7.0% showed significantly lower 1,5-AG than their counterparts of the control subjects. Stepwise multivariable analysis revealed that estimated HbA(1C) was the significant explanatory variable for 1,5-AG in the CLD patients. However, in the CLD patients with estimated HbA(1C) less than 5.8%, only hepaplastin test was the significant explanatory variable for 1,5-AG.
  
  
  CONCLUSIONS
  Serum 1,5-AG levels are low irrespective of plasma glucose levels in the CLD patients with and without diabetes. The CLD patients who had low serum 1,5-AG levels were associated with deteriorated liver function.
authors.affiliation: Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. koga_m@kich.itami.hyogo.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
authors.forename: Jun
authors.initials: J
authors.lastname: Murai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Mikio
authors.initials: M
authors.lastname: Mukai
authors.forename: Daishu
authors.initials: D
authors.lastname: Toya
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hideo
authors.initials: H
authors.lastname: Kanehara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Bando
authors.forename: Soji
authors.initials: S
authors.lastname: Kasayama
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D002908:Chronic Disease; D003847:Deoxyglucose / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose