title: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children.
abstract: Our objective was to compare the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Forty children aged 1-11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts to an 8-week course of ultramicronized griseofulvin dosed at 10-12 mg/kg/day. At weeks 2, 4, and 8, subjects returned to the clinic for evaluation and scalp cultures. Subjects then returned for follow-up visits 4 weeks after completing treatment. Overall, by 8 weeks, 30 of 33 (90.9%) treated children demonstrated mycological cure. Selenium sulfide shampoo 1% and ciclopirox shampoo 1% were equally effective as adjunctive treatments for tinea capitis in children in our study.
authors.affiliation: Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chen
authors.forename: Laine H
authors.initials: LH
authors.lastname: Koch
authors.forename: James E
authors.initials: JE
authors.lastname: Dice
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Dempsey
authors.forename: Alan B
authors.initials: AB
authors.lastname: Moskowitz
authors.forename: Myra L
authors.initials: ML
authors.lastname: Barnes-Eley
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Hubbard
authors.forename: Judith V
authors.initials: JV
authors.lastname: Williams
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D000077768:Ciclopirox; D004311:Double-Blind Method; D005260:Female; D006203:Hair Preparations / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011728:Pyridones / Q000627:therapeutic use*; D018036:Selenium Compounds / Q000627:therapeutic use*; D014006:Tinea Capitis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D006203:Hair Preparations; D011728:Pyridones; D018036:Selenium Compounds; D000077768:Ciclopirox; C025698:selenium disulfide