title: Upfront VIP-reinforced-ABVD (VIP-rABVD) is not superior to CHOP/21 in newly diagnosed peripheral T cell lymphoma. Results of the randomized phase III trial GOELAMS-LTP95.
abstract: Peripheral T-Cell lymphomas (PTCL) are relatively rare diseases but appear to be highly aggressive and display worse remission and survival rates than B-cell lymphomas. Despite unsatisfactory results with the cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) regimen, it remains the reference front-line therapy in these diseases, but has not been challenged in phase III trials. The Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang (GOELAMS) devised an alternative therapeutic schedule including etoposide, ifosfamide, cisplatin alternating with doxorubicin, bleomycin, vinblastine, dacarbazine (VIP-reinforced-ABVD; VIP-rABVD) and compared it to CHOP/21 as front-line treatment in non-cutaneous PTCL. All newly diagnosed patients were eligible. The primary objective was to improve the 2-year event-free survival (EFS) rate. Secondary objectives were to compare the response rate, overall survival, and toxicities as well as identify prognostic factors. Eighty-eight patients were identified between 1996 and 2002. Both arms were well balanced for patients' characteristics in terms of histological and clinical presentation. No significant difference was observed between the two arms in terms of 2-year EFS. Anaplastic large cell lymphoma type and Ann Arbor stage I-II were identified as two independent favourable prognostic factors influencing survival. VIP-rABVD was not superior to CHOP/21 in terms of EFS as first-line treatment of PTCL, confirming that CHOP/21 remains the reference regimen in these lymphomas.
authors.affiliation: Centre Hospitalo-Universitaire Grenoble, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Simon
authors.forename: Michel
authors.initials: M
authors.lastname: Peoch
authors.forename: Philippe
authors.initials: P
authors.lastname: Casassus
authors.forename: Eric
authors.initials: E
authors.lastname: Deconinck
authors.forename: Philippe
authors.initials: P
authors.lastname: Colombat
authors.forename: Bernard
authors.initials: B
authors.lastname: Desablens
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
authors.forename: Houchingue
authors.initials: H
authors.lastname: Eghbali
authors.forename: Charles
authors.initials: C
authors.lastname: Foussard
authors.forename: Jerome
authors.initials: J
authors.lastname: Jaubert
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Vilque
authors.forename: Jean François
authors.initials: JF
authors.lastname: Rossi
authors.forename: Virginie
authors.initials: V
authors.lastname: Lucas
authors.forename: Vincent
authors.initials: V
authors.lastname: Delwail
authors.forename: Antoine
authors.initials: A
authors.lastname: Thyss
authors.forename: Frederic
authors.initials: F
authors.lastname: Maloisel
authors.forename: Noel
authors.initials: N
authors.lastname: Milpied
authors.forename: Steven
authors.initials: S
authors.lastname: le Gouill
authors.forename: Thierry
authors.initials: T
authors.lastname: Lamy
authors.forename: Rémy
authors.initials: R
authors.lastname: Gressin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003606:Dacarbazine / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects; D016411:Lymphoma, T-Cell, Peripheral / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D016019:Survival Analysis; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D055815:Young Adult
chemical_list: D001761:Bleomycin; D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide; D011241:Prednisone