MeCP2 and drug addiction.
Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in establishing drug addiction.
Feng
Jian
J
Nestler
Eric J
EJ
D019969:Amphetamine-Related Disorders / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000235:genetics / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008959:Models, Neurological; D009483:Neuropsychological Tests; D051381:Rats; D019966:Substance-Related Disorders / Q000235:genetics / Q000378:metabolism*
D000697:Central Nervous System Stimulants; C497393:Mecp2 protein, mouse; C497394:Mecp2 protein, rat; D051783:Methyl-CpG-Binding Protein 2