title: Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs.
abstract: The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN). It was found that SN-1 targeted trophozoites and had a synergistic effect when combined with CQ and QN; however, it had an antagonist effect when used with the other combinations.
authors.affiliation: Malaria Group, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Pabón
authors.forename: Eric
authors.initials: E
authors.lastname: Deharo
authors.forename: Silvia
authors.initials: S
authors.lastname: Blair
mesh_terms: D000655:Amodiaquine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000962:Antimalarials / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D037621:Artemisinins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D053626:Atovaquone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004357:Drug Synergism; D004912:Erythrocytes / Q000469:parasitology; D005434:Flow Cytometry; D006801:Humans; D010840:Phytosterols / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D032322:Solanum / Q000737:chemistry*; D053058:Trophozoites / Q000187:drug effects
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D010840:Phytosterols; D000655:Amodiaquine; C047386:desethylamodiaquine; D002738:Chloroquine; C031327:artemisinin; D011803:Quinine; D053626:Atovaquone