title: Prophylactic treatment for hypertension and seizure in a case of allogeneic hematopoietic stem cell transplantation after posterior reversible encephalopathy syndrome.
abstract: A six-yr-old boy developed PRES after induction chemotherapy for the relapse of acute lymphoblastic leukemia. Two months after PRES, he underwent BMT from an unrelated HLA-mismatched donor. There were many risk factors for PRES in the BMT including the long-term use of FK506 and methylprednisolone, grade III graft-versus-host disease, thrombotic microangiopathy, and sepsis. Prophylactic treatment for hypertension with nicardipine in conjunction with close monitoring of the magnesium level and the use of valproic acid might be an effective management approach to prevent post-transplant PRES.
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. fukuyama@shinshu-u.ac.jp
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yozo
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Motoki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Inaba
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Higuchi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Koike
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D008279:Magnetic Resonance Imaging; D008297:Male; D054038:Posterior Leukoencephalopathy Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D011859:Radiography; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014184:Transplantation, Homologous; D061349:Unrelated Donors
chemical_list: D000927:Anticonvulsants; D000959:Antihypertensive Agents