Regulatory T cell immunotherapy for transplantation tolerance: step into clinic.
Recent studies in animal models have demonstrated that adoptive transfer of antigen-specific CD4+CD25+ regulatory T cells (Tregs) can prevent or even cure autoimmune diseases, and appear to induce transplantation tolerance. Thus, adoptive cell therapy using ex vivo induced and expanded patient-specific CD4+CD25+Tregs has emerged as a promising individualized medicine for the treatment of inflammatory disease. Here we discuss our current efforts on the pursuit of regulatory T cell therapy for the induction of transplantation tolerance.
Jiang
Shuiping
S
Laboratory of Translational Research Centre, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. shuiping.jiang@chinatregs2008.com
Tsang
Julia
J
Tam
Paul
P
D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D017321:Clinical Trials, Phase I as Topic; D006086:Graft vs Host Disease / Q000276:immunology / Q000628:therapy*; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000637:transplantation*; D023001:Transplantation Tolerance / Q000276:immunology*
D015704:CD4 Antigens; D053645:Interleukin-2 Receptor alpha Subunit