title: Is decompressive surgery effective for spinal cord sarcoidosis accompanied with compressive cervical myelopathy?
abstract: METHODS
  A retrospective multicenter study of series of 12 patients with spinal cord sarcoidosis who underwent surgery.
  
  
  OBJECTIVE
  To evaluate the postoperative outcomes of patients with cervical spinal cord sarcoidosis accompanied with compressive myelopathy and effect of decompressive surgery on the prognosis of sarcoidosis.
  
  
  BACKGROUND
  Sarcoidosis is a chronic, multisystem noncaseating granulomatous disease. It is difficult to differentiate spinal cord sarcoidosis from cervical compressive myelopathy. There are no studies regarding the coexistence of compressive cervical myelopathy with cervical spinal cord sarcoidosis and the effect of decompressive surgery.
  
  
  METHODS
  Nagoya Spine Group database included 1560 cases with cervical myelopathy treated with cervical laminectomy or laminoplasty from 2001 to 2005. A total of 12 patients (0.08% of cervical myelopathy) were identified spinal cord sarcoidosis treated with decompressive surgery. As a control subject, 8 patients with spinal cord sarcoidosis without compressive lesion who underwent high-dose steroid therapy without surgery were recruited.
  
  
  RESULTS
  In the surgery group, enhancing lesions on magnetic resonance imaging (MRI) were mostly seen at C5-C6, coincident with the maximum compression level in all cases. Postoperative recovery rates in the surgery group at 1 week and 4 weeks were -7.4% and -1.1%, respectively. Only 5 cases had showed clinical improvement, and the condition of these 5 patients had worsened again at averaged 7.4 weeks after surgery. Postoperative oral steroid therapy was initiated at an average of 6.4 weeks and the average initial dose was 54.0 mg in the surgery group, while 51.3 mg in the nonsurgery group. The recovery rate of the Japanese Orthopedic Association score, which increased after steroid therapy, was better in the nonsurgery group (62.5%) than in the surgery group (18.6%) with significant difference (P < 0.01).
  
  
  CONCLUSIONS
  The effect of decompression for spinal cord sarcoidosis with compressive myelopathy was not evident. Early diagnosis for sarcoidosis from other organ and steroid therapy should be needed.
authors.affiliation: Department of Orthopaedic Surgery, Nagoya University School of Medicine, Aichi Prefecture, Japan. jsakai@ncgg.go.jp
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Sakai
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Matsuyama
authors.forename: Shiro
authors.initials: S
authors.lastname: Imagama
authors.forename: Zenya
authors.initials: Z
authors.lastname: Ito
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Wakao
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Watanabe
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kato
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Yukawa
authors.forename: Keigo
authors.initials: K
authors.lastname: Ito
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akiko
authors.initials: A
authors.lastname: Tsuboi
authors.forename: Tokumi
authors.initials: T
authors.lastname: Kanemura
authors.forename: Go
authors.initials: G
authors.lastname: Yoshida
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D002574:Cervical Vertebrae / Q000601:surgery*; D016208:Databases, Factual; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D013117:Spinal Cord Compression / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D013118:Spinal Cord Diseases / Q000188:drug therapy / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones