title: Prevalence of benign cutaneous disease among Oxford renal transplant recipients.
abstract: BACKGROUND
  The burden of malignant and benign cutaneous disease among renal transplant recipients (RTR) is substantial. Little attention is given to non-malignant skin problems in the literature despite their potential impact on quality of life or on aesthetics - which may contribute to poor compliance with immunosuppressive medications post-transplantation.
  
  
  OBJECTIVE
  The aim of this study was to examine prevalence of benign cutaneous disease in a group of RTRs and identify risk factors for individual cutaneous conditions.
  
  
  METHODS
  All cutaneous findings were recorded in a single full body skin examination of 308 RTRs. Data on medical, transplant and medication history were obtained from questionnaire and medical records. Odds ratios were calculated to look at associations between benign cutaneous diseases and various potential risk factors after controlling for gender, age, time since transplantation and skin type.
  
  
  RESULTS
  Cutaneous infections such as viral warts (38%), fungal infection (18%) and folliculitis (27%) were common and usually chronic. A range of pilosebaceous unit disorders were observed with hypertrichosis being strongly associated with ciclosporin (P<0.0001). Other iatrogenic cutaneous effects included gingival hyperplasia (27%) and purpura (41%). We identified seborrhoeic warts and skin tags in 55% and 33% respectively. Inflammatory dermatoses were rare (<2%) apart from seborrhoeic dermatitis (9.5%).
  
  
  CONCLUSIONS
  In this first comprehensive study on prevalence of benign cutaneous diseases in a UK transplant population, a wide range of skin disorders was identified. It is therefore important that RTRs have access to dermatology services post-transplantation for appropriate management of benign cutaneous conditions as well as early detection of cutaneous malignancy and education regarding risks of sun exposure.
authors.affiliation: Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, UK. aoife.lally@royalfree.nhs.uk
authors.forename: A
authors.initials: A
authors.lastname: Lally
authors.forename: D
authors.initials: D
authors.lastname: Casabonne
authors.forename: B
authors.initials: B
authors.lastname: Imko-Walczuk
authors.forename: R
authors.initials: R
authors.lastname: Newton
authors.forename: F
authors.initials: F
authors.lastname: Wojnarowska
mesh_terms: D000328:Adult; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D012871:Skin Diseases / Q000453:epidemiology* / Q000209:etiology; D011795:Surveys and Questionnaires