title: Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia.
abstract: Gestational trophoblastic neoplasia (GTN) includes invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The overall cure rate in treating these tumors is currently >90%. Thorough evaluation and staging allow selection of appropriate therapy that maximizes chances for cure while minimizing toxicity. Nonmetastatic (stage I) and low-risk metastatic (stages II and III, score <7) GTN can be treated with single-agent chemotherapy resulting in a survival rate approaching 100%. High-risk GTN (stages II-IV, score ≥7) requires initial multiagent chemotherapy with or without adjuvant radiation and surgery to achieve a survival rate of 80-90%.
authors.affiliation: John I. Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. jlurain@nmff.org
authors.forename: John R
authors.initials: JR
authors.lastname: Lurain
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis; D003609:Dactinomycin / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000145:classification* / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009367:Neoplasm Staging / Q000379:methods; D011247:Pregnancy; D012074:Remission Induction; D017211:Treatment Failure
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D003609:Dactinomycin; D002955:Leucovorin; D008727:Methotrexate