Current concepts of follicle-stimulating hormone receptor gene regulation.
Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and granulosa cells of the ovary. Thus, both the magnitude and the target of hormone response are controlled by mechanisms that determine FSHR levels and cell-specific expression, which are supported by transcription of its gene. The present review examines the status of FSHR/Fshr gene regulation, emphasizing the importance of distal sequences in FSHR/Fshr transcription, new insights gained from the influx of genomics data and bioinformatics, and emerging trends that offer direction in deciphering the FSHR/Fshr regulatory landscape.
George
Jitu W
JW
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Dille
Elizabeth A
EA
Heckert
Leslie L
LL
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D011962:Receptors, FSH / Q000235:genetics / Q000378:metabolism*; D050436:Regulatory Elements, Transcriptional / Q000502:physiology
D011962:Receptors, FSH