title: A model for the preferential delivery of isoflurane to the spinal cord of the goat.
abstract: To identify the blood supply of the caprine central nervous system, six anaesthetised goats were perfused with coloured suspension into the brachiocephalic artery, the aorta, the iliac artery and the femoral artery. The subsequent distribution indicated that the brain and the main segments of the spinal cord were supplied by the brachiocephalic artery and aorta, respectively. Ten similarly anaesthetised goats then received emulsified isoflurane randomly via either the proximal part of the descending aorta (arterial group) or an ear vein (venous group). In the arterial group, the isoflurane partial pressure (P(iso)) in femoral arterial blood was almost double the P(iso) in jugular venous blood. The model showed that preferential delivery of isoflurane to the goat spinal cord in situ was possible and could be used for further research into the mechanisms of anaesthetic action, particularly factors affecting immobility.
authors.affiliation: Laboratory of Anaesthesia and Critical Care Medicine, State Key Laboratory of Biotherapy of Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Gong
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Chai
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Luo
authors.forename: Nan-Fu
authors.initials: NF
authors.lastname: Luo
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D002490:Central Nervous System / Q000098:blood supply; D004655:Emulsions; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D006041:Goats / Q000502:physiology*; D007530:Isoflurane / Q000008:administration & dosage*; D007601:Jugular Veins / Q000502:physiology; D008297:Male; D023421:Models, Animal; D010313:Partial Pressure; D011897:Random Allocation; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
chemical_list: D018685:Anesthetics, Inhalation; D004655:Emulsions; D007530:Isoflurane