Evidence of involvement of the human Par-4 (PAWR) gene in major depressive disorder.
QBJECTIVES: The aim of the study was to examine the associations between genetic variations in the human PAWR gene and major depressive disorder (MDD) as well as the response to antidepressant treatment.


METHODS
Six-hundred and two patients with MDD and 543 controls were included in the study; among the MDD patients, 268 were followed-up for a further 8 weeks in order to assess their response to treatment with selective serotonin reuptake inhibitors (SSRIs). Six polymorphisms (rs17005769, rs4842318, rs7305141, rs2307223, rs8176874 and rs2307220) of the PAWR gene were investigated with regard to their association with MDD and antidepressant treatment efficacy.


RESULTS
One polymorphism, rs8176874, was in genotypic (uncorrected P=0.005) and allelic (uncorrected P=0.0015) association with MDD. Several haplotypes spanning rs7305141-rs2307223-rs8176874 were also significantly associated with MDD after correction for multiple testing (corrected P<0.05). However, neither single-marker nor haplotype-based analyses suggested an association between the studied markers and SSRI treatment response.


CONCLUSIONS
Genetic variations in the PAWR gene are related to susceptibility to MDD but not to SSRI treatment response.
Liou
Ying-Jay
YJ
Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chen
Tai-Jui
TJ
Tsai
Shih-Jen
SJ
Yu
Younger W-Y
YW
Chen
Shiow-Yi
SY
Cheng
Chih-Ya
CY
Hong
Chen-Jee
CJ
D000328:Adult; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects / Q000235:genetics; D018179:Receptors, Thrombin / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
D018179:Receptors, Thrombin; D017367:Selective Serotonin Reuptake Inhibitors; C112908:protease-activated receptor 4