title: Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate.
abstract: BACKGROUND
  Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis.
  
  
  RESULTS
  We present a case report of a patient with nasopharyngeal carcinoma who was treated with high-dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later.
  
  
  CONCLUSIONS
  Systemic high-dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Carole
authors.initials: C
authors.lastname: Fakhry
authors.forename: Gopal
authors.initials: G
authors.lastname: Bajaj
authors.forename: Nafi
authors.initials: N
authors.lastname: Aygun
authors.forename: William
authors.initials: W
authors.lastname: Westra
authors.forename: Maura
authors.initials: M
authors.lastname: Gillison
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D055756:Meningeal Carcinomatosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D008727:Methotrexate / Q000008:administration & dosage*; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D009361:Neoplasm Invasiveness; D011879:Radiotherapy Dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate