New insights into the molecular mechanisms of general anaesthetics.
This paper provides new insights of how general anaesthetic research should be carried out in the future by an analysis of what we know, what we do not know and what we would like to know. I describe previous hypotheses on the mechanism of action of general anaesthetics (GAs) involving membranes and protein receptors. I provide the reasons why the GABA type A receptor, the NMDA receptor and the glycine receptor are strong candidates for the sites of action of GAs. I follow with a review on attempts to provide a mechanism of action, and how future research should be conducted with the help of physical and chemical methods.
Chau
P-L
PL
Bioinformatique Structurale, CNRS URA 2185, Institut Pasteur, Paris, France. pc104@pasteur.fr
D018681:Anesthetics, General / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D017354:Point Mutation; D011485:Protein Binding; D011963:Receptors, GABA-A / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D018681:Anesthetics, General; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate