title: Preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography imaging in head and neck cancer: does it really improve initial N staging?
abstract: CONCLUSIONS
  In our experience PET-CT cannot yet reliably predict the need for surgical neck dissection in patients with N0 neck. According to the results of PET-CT the neck dissection should be extended towards unusual lymph node areas.
  
  
  OBJECTIVE
  To analyze the value of PET-CT for the initial N staging, comparing PET-CT data with histopathological results of the modified radical neck dissection.
  
  
  METHODS
  Fifty patients with previously untreated head and neck squamous cell carcinoma were eligible for inclusion in this study. Modified radical unilateral or bilateral neck dissection was performed in all patients. PET-CT findings and histological findings were compared to determine their diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value.
  
  
  RESULTS
  In all, 105 levels had pathologically diagnosed metastases: PET-CT was positive in 87 levels and negative in 18 levels. Also, 399 levels had negative postoperative histology findings: PET-CT was positive in 24 levels and negative in 375 levels. The false-positive over-staged and the false-negative under-staged rates were 27% and 12%, respectively.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, North Hospital, University Hospital Centre, Saint-Etienne, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Richard
authors.forename: Nathalie
authors.initials: N
authors.lastname: Prevot
authors.forename: Andrei P
authors.initials: AP
authors.lastname: Timoshenko
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dumollard
authors.forename: Francis
authors.initials: F
authors.lastname: Dubois
authors.forename: Christian
authors.initials: C
authors.lastname: Martin
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Prades
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18