Handling accumulated internal Cl- at inhibitory synapses.
A study in this issue finds that under conditions of intense activity at specific inhibitory synapses, the voltage gated Cl- channel CIC-2 is vital for allowing efflux of accumulated internal Cl-.
Smart
Trevor G
TG
D000818:Animals; D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D051379:Mice; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000090007:CLC-2 Chloride Channels; D018118:Chloride Channels; D002712:Chlorides; D005680:gamma-Aminobutyric Acid