Analysis of Syk expression in bovine lymphoma and persistent lymphocytosis induced by bovine leukemia virus.
Spleen tyrosine kinase (Syk) is closely related to various cell reactions. In B-cells, Syk is involved in early B-cell receptor signaling, which affects cellular survival, proliferation and differentiation. Although the kinetics of Syk mRNA and its activity are variable in different types of tumor cells, Syk may have a relation to tumor progression in many human tumors, including B-cell lymphoma/leukemia. In this study we examined whether Syk mRNA expression was changed in bovine leukemia virus (BLV)-induced persistent lymphocytosis (PL) and lymphoma. As a result, we demonstrated that the Syk mRNA expression was significantly increased in PL samples, whereas it was decreased in tumor samples. Moreover one cow, which Syk mRNA expression has been lowest among PL cattle, developed lymphoma three months later and the expression significantly decreased. These data suggest that Syk mRNA expression dynamics is closely related to BLV-induced disease.
Murakami
Hironobu
H
Laboratory of Veterinary Epizootiology, School of Veterinary Medicine, Nihon University, Kanagawa, Japan.
Kuroiwa
Toshihiro
T
Suzuki
Kazuhiko
K
Miura
Yasuo
Y
Sentsui
Hiroshi
H
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism* / Q000821:virology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D001909:Leukemia Virus, Bovine / Q000502:physiology*; D008223:Lymphoma / Q000378:metabolism / Q000662:veterinary*; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D000072377:Syk Kinase
D047908:Intracellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase