title: Severe cardiac conduction disturbances and pacemaker implantation in patients with hypertrophic cardiomyopathy.
abstract: The aims of this study were to determine the prevalence of severe cardiac conduction disturbances in a cohort of 451 patients with hypertrophic cardiomyopathy and to describe the characteristics of, and outcomes in, those who required a permanent pacemaker. A pacemaker was implanted in 48 patients (11%): 20 had sinus node dysfunction and 28 had an atrioventricular conduction disturbance. Primary bradyarrhythmia (which was not related to iatrogenic atrioventricular block or therapeutic ablation of the atrioventricular node) was the reason for permanent pacemaker implantation in 36 patients (8%). In 18% of cases, at least one other family member had a permanent pacemaker. In this patient series, a high prevalence of severe cardiac conduction disturbance leading to permanent pacemaker implantation was observed. Severe cardiac conduction disturbance in hypertrophic cardiomyopathy may also have a familial component.
authors.affiliation: Instituto de Investigación Biomédica de A Coruña, A Coruña, España. rbarrialesv@gmail.com
authors.forename: Roberto
authors.initials: R
authors.lastname: Barriales-Villa
authors.forename: Raúl
authors.initials: R
authors.lastname: Centurión-Inda
authors.forename: Xusto
authors.initials: X
authors.lastname: Fernández-Fernández
authors.forename: Martín F
authors.initials: MF
authors.lastname: Ortiz
authors.forename: Luisa
authors.initials: L
authors.lastname: Pérez-Alvarez
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodríguez García
authors.forename: Manuel
authors.initials: M
authors.lastname: Hermida-Prieto
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Monserrat
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000628:therapy*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012189:Retrospective Studies; D012720:Severity of Illness Index