Silica nanoparticles as a delivery system for nucleic acid-based reagents.
The transport of nucleic acid-based reagents is predicated upon developing structurally stable delivery systems that can preferentially bind and protect DNA and RNA, and release their cargo upon reaching their designated sites. Recent advancements in tailoring the size, shape, and external surface functionalization of silica materials have led to increased biocompatibility and efficiency of delivery. In this Feature Article, we highlight recent research progress in the use of silica nanoparticles as a delivery vehicle for nucleic acid-based reagents.
Hom
Christopher
C
Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, 609 Charles E. Young Drive East, Los Angeles, CA, 90095, USA. fuyut@microbio.ucla.edu ; ; Tel: (+310) 206-7318.
Lu
Jie
J
Tamanoi
Fuyuhiko
F