title: Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort.
abstract: BACKGROUND
  The Surveillance, Epidemiology, and End Results database was analyzed to explore the pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy as well as the use of adjuvant radiation in this population.
  
  
  METHODS
  Identified were patients from 2004 to 2006 with clinically staged T1c-2cNx-0M0 prostate adenocarcinoma who underwent radical prostatectomy. All patients had complete clinical and pathologic data. The use of postoperative radiation was recorded. Logistic regression analysis was performed to identify unadjusted and adjusted predictors for extraprostatic disease or positive surgical margins and for adjuvant radiation use.
  
  
  RESULTS
  A total of 35,642 patients were identified. For those patients with Gleason 7 (4 + 3) and a prostate-specific antigen (PSA) level of ≥10.1 ng/mL or Gleason 8 to 10 with any PSA level, the rate of organ-confined disease with negative surgical margins was found to be <50%. Of those with indications for adjuvant radiation, 11.1% received the treatment.
  
  
  CONCLUSIONS
  This large population-based study detailed the risk of extraprostatic extension and positive surgical margins in a broad setting across multiple regions and communities, as well as the use of adjuvant radiation for these patients. As of 2006, 11.1% of patients who had indications for adjuvant radiation received this treatment, providing a useful baseline for future patterns of care studies.
authors.affiliation: Department of Radiation Oncology, State University of New York Downstate Medical Center, Brooklyn, New York, USA. david.schreiber@downstate.edu
authors.forename: David
authors.initials: D
authors.lastname: Schreiber
authors.forename: Justin
authors.initials: J
authors.lastname: Rineer
authors.forename: James B
authors.initials: JB
authors.lastname: Yu
authors.forename: Michelle
authors.initials: M
authors.lastname: Olsheski
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Nwokedi
authors.forename: David
authors.initials: D
authors.lastname: Schwartz
authors.forename: Kwang
authors.initials: K
authors.lastname: Choi
authors.forename: Marvin
authors.initials: M
authors.lastname: Rotman
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000532:radiotherapy; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D018426:SEER Program