title: Thyroid volume in Swedish school children: a national, stratified, population-based survey.
abstract: OBJECTIVE
  Sweden has had a salt iodination program since 1936. This first national surveillance study on iodine nutrition infers an adequate level of urinary iodine concentration (UIC 125 μg/l) and the aim is now to evaluate thyroid volume (Tvol) in the same national sample.
  
  
  METHODS
  A stratified probability proportionate to size cluster sampling was used to obtain a representative national sample of Swedish children aged 6-12 years. Median Tvol obtained ultrasonographically and the prevalence of enlarged thyroid glands were compared with an international reference standard. Regional differences were evaluated through comparisons of Tvol between coastal and inland areas, urban and rural regions, and former goitre and non-goitre regions.
  
  
  RESULTS
  Tvol was correlated with age, body surface area (BSA), weight, height and body mass index for both sexes (P<0.0001) but not with UIC. The most important predictors for Tvol were age (girls: P<0.0001, boys: P=0.001) and BSA (girls: P<0.0001, boys: P<0.01). Median Tvol was higher in Sweden than in the reference study (P<0.0001). The prevalence of goitre was higher in Sweden (correlated to age 22.3%, BSA 15.7%, weight 17.6%, height 12.9%) than in the international reference (correlated to age 2.5%, BSA 2.5%, weight 2.5%, height 2.5%) (P<0.0001). Thyroids were larger in boys from urban and former non-goitre areas.
  
  
  CONCLUSIONS
  Tvols were higher in Swedish school children than in the international reference study although iodine intake is considered optimal in Sweden. These findings underline the importance of regular monitoring of iodine intake, especially with regard to the decreased intake of table salt that is likely to follow initiation of health campaigns.
authors.affiliation: Department of Endocrinology, Sahlgrenska University Hospital, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. helena.filipsson@telia.com
authors.forename: H
authors.initials: H
authors.lastname: Filipsson Nyström
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: G
authors.initials: G
authors.lastname: Berg
authors.forename: R
authors.initials: R
authors.lastname: Eggertsen
authors.forename: E
authors.initials: E
authors.lastname: Gramatkowski
authors.forename: M
authors.initials: M
authors.lastname: Hansson
authors.forename: L
authors.initials: L
authors.lastname: Hulthén
authors.forename: M
authors.initials: M
authors.lastname: Milakovic
authors.forename: E
authors.initials: E
authors.lastname: Nyström
mesh_terms: D000367:Age Factors; D002648:Child; D005260:Female; D006042:Goiter / Q000000981:diagnostic imaging / Q000453:epidemiology*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage; D008297:Male; D009929:Organ Size; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D012016:Reference Values; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D014505:Urban Population
chemical_list: D007455:Iodine