title: AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents.
abstract: Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-Gd(III) complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.
authors.affiliation: Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, 15121, Alessandria, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gugliotta
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
mesh_terms: D001381:Azepines / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D014867:Water / Q000737:chemistry
chemical_list: C511496:6-amino-6-methylperhydro-1,4-diazepine; D001381:Azepines; D002614:Chelating Agents; D003287:Contrast Media; D050091:Dendrimers; D014867:Water; D005682:Gadolinium