title: Selective synthesis of either isoindole- or isoindoline-1-carboxylic acid esters by Pd(0)-catalyzed enolate arylation.
abstract: Two efficient palladium-catalyzed intramolecular α-arylation reactions of α-amino acid esters have been developed that allow either 1-isoindolecarboxylic acid esters or the corresponding isoindolines to be selectively synthesized simply by a slight change of reaction conditions.
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, and Institut de Biomedicina, Universitat de Barcelona, 08028 Barcelona, Spain. dsole@ub.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Solé
authors.forename: Olga
authors.initials: O
authors.lastname: Serrano
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002264:Carboxylic Acids; D004952:Esters; D054833:Isoindoles; D010165:Palladium