title: Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus.
abstract: We describe the first reported case of a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by low-dose tacrolimus in a patient with autoimmune disease. A 41-year-old man with systemic lupus erythematosus (SLE) developed hyponatremia induced by SIADH after administration of tacrolimus (0.06 mg/kg per day). In this case, the hyponatremia promptly resolved upon withdrawal of tacrolimus. This case strongly suggests that SIADH is a potentially important complication of tacrolimus administration, irrespective of dosage, and should be borne in mind whenever the drug is used.
authors.affiliation: Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan. suemori@m.ehime-u.ac.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Suemori
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Chika
authors.initials: C
authors.lastname: Nanba
authors.forename: Masashi
authors.initials: M
authors.lastname: Kohno
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawamoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Murakami
authors.forename: Eiji
authors.initials: E
authors.lastname: Sada
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masaki
authors.initials: M
authors.lastname: Yasukawa
mesh_terms: D000328:Adult; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008297:Male; D016559:Tacrolimus / Q000009:adverse effects*; D028761:Withholding Treatment
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus