title: [Study of phosphorylated ERK1/2 on nasal polyps].
abstract: OBJECTIVE
  To study the expression of phosphorylated extracellular regulator kinase (ERK1/2) on nasal polyps.
  
  
  METHODS
  The immunohistochemistry and Western-blot were used to study the phosphorylation of ERK1/2 on the normal nasal mucosa and nasal polyps.
  
  
  RESULTS
  The phosphorylated ERK1/2 was mainly expressed on the hyperplastic epithelium, inflammatory cells, glandular epithelium and endothelium of nasal polyps by immunohistochemistry, which was much stronger on nasal polyps than that of normal mucosa. The expression of phosphorylated ERK1/2 was 4.2 times than that of normal mucosa.
  
  
  CONCLUSIONS
  The study indicated that the phosphorylation of ERK1/2 might play an important role on the occurrence and progression of nasal polyps.
authors.affiliation: Department of Otolaryngology,the Third Xiangya Hospital,Central South University, Changsha, 410013, China. tswheaven@hotmail.com
authors.forename: Tiansheng
authors.initials: T
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Chu
authors.forename: Jiangbo
authors.initials: J
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Gengsheng
authors.initials: G
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D009298:Nasal Polyps / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D055815:Young Adult
chemical_list: C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3