title: Defining the risks of mesenchymal stromal cell therapy.
abstract: Abstract We address the issue of the potential for malignant transformation of cultured mesenchymal stromal cells (MSC) commonly used in clinical cell-therapy protocols and describe the culture conditions under which tumorigenesis is likely to be an extremely uncommon event.
authors.affiliation: Texas A&M Health Science College of Medicine, Institute for Regenerative Medicine at Scott & White, Temple, TX 76502, USA. Prockop@medicine.tamhsc.edu
authors.forename: Darwin J
authors.initials: DJ
authors.lastname: Prockop
authors.forename: Malcolm
authors.initials: M
authors.lastname: Brenner
authors.forename: Willem E
authors.initials: WE
authors.lastname: Fibbe
authors.forename: Edwin
authors.initials: E
authors.lastname: Horwitz
authors.forename: Katarina
authors.initials: K
authors.lastname: Le Blanc
authors.forename: Donald G
authors.initials: DG
authors.lastname: Phinney
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Simmons
authors.forename: Luc
authors.initials: L
authors.lastname: Sensebe
authors.forename: Armand
authors.initials: A
authors.lastname: Keating
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D018929:Cell Culture Techniques; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence; D002986:Clinical Trials as Topic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects*; D059630:Mesenchymal Stem Cells / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D012307:Risk Factors; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology / Q000637:transplantation; D019098:Telomerase / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019098:Telomerase