Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps.
The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.
Hariharan
Mahesh
M
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
McCullagh
Martin
M
Schatz
George C
GC
Lewis
Frederick D
FD
D004277:DNA, Single-Stranded / Q000737:chemistry*; D019281:Dimerization; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D055668:Photochemical Processes; D013941:Thymine / Q000737:chemistry*
D004277:DNA, Single-Stranded; D009841:Oligonucleotides; C477371:locked nucleic acid; D013941:Thymine