Persistence of human bocavirus DNA in immunocompromised children.
Human bocavirus is frequently detected in immunocompetent as well as in immunocompromised children. However, the course of infection in immunocompromised children is still poorly investigated. In the present study, we describe 4 cases of repeat human bocavirus detection in the presence of severe immunodeficiency. In the view of homologous viral sequences identified in serial samples, possible persistence and reactivation in these patients are discussed.
Schenk
Thomas
T
Department of Virology, Freiburg University Medical Center, Freiburg, Germany.
Maier
Barbara
B
Hufnagel
Markus
M
Strahm
Brigitte
B
Kontny
Udo
U
Neumann-Haefelin
Dieter
D
Falcone
Valeria
V
D000293:Adolescent; D002675:Child, Preschool; D004279:DNA, Viral / Q000378:metabolism*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D056661:Human bocavirus / Q000235:genetics*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000821:virology; D010322:Parvoviridae Infections / Q000276:immunology / Q000821:virology*; D016133:Polymerase Chain Reaction; D019562:Viral Load
D004279:DNA, Viral