A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe.
The phylogenetic relationships of numerous branches within the core Y-chromosome haplogroup R-M207 support a West Asian origin of haplogroup R1b, its initial differentiation there followed by a rapid spread of one of its sub-clades carrying the M269 mutation to Europe. Here, we present phylogeographically resolved data for 2043 M269-derived Y-chromosomes from 118 West Asian and European populations assessed for the M412 SNP that largely separates the majority of Central and West European R1b lineages from those observed in Eastern Europe, the Circum-Uralic region, the Near East, the Caucasus and Pakistan. Within the M412 dichotomy, the major S116 sub-clade shows a frequency peak in the upper Danube basin and Paris area with declining frequency toward Italy, Iberia, Southern France and British Isles. Although this frequency pattern closely approximates the spread of the Linearbandkeramik (LBK), Neolithic culture, an advent leading to a number of pre-historic cultural developments during the past ≤10 thousand years, more complex pre-Neolithic scenarios remain possible for the L23(xM412) components in Southeast Europe and elsewhere.
Myres
Natalie M
NM
Sorenson Molecular Genealogy Foundation, Salt Lake City, UT, USA.
Rootsi
Siiri
S
Lin
Alice A
AA
Järve
Mari
M
King
Roy J
RJ
Kutuev
Ildus
I
Cabrera
Vicente M
VM
Khusnutdinova
Elza K
EK
Pshenichnov
Andrey
A
Yunusbayev
Bayazit
B
Balanovsky
Oleg
O
Balanovska
Elena
E
Rudan
Pavao
P
Baldovic
Marian
M
Herrera
Rene J
RJ
Chiaroni
Jacques
J
Di Cristofaro
Julie
J
Villems
Richard
R
Kivisild
Toomas
T
Underhill
Peter A
PA
D044466:Asian People / Q000235:genetics*; D005075:Biological Evolution; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004641:Emigration and Immigration; D005060:Europe; D018703:Founder Effect; D051456:Gene Flow; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D010802:Phylogeny; D044465:White People / Q000235:genetics*