The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor.
The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor, was accomplished in an overall high yielding reaction sequence. A convergent synthetic approach was adopted; the erythritol segment of the molecule was derived from L-arabinose, whereas hydroxyphenylpyruvic acid oxime was built up from 4-hydroxybenzaldehyde.
Ullah
Nisar
N
Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. nullah@kfupm.edu.sa
Haladu
Shamsuddeen A
SA
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; C545427:aspergillusol A; D014443:Tyrosine