title: Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development.
abstract: We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women.
authors.affiliation: Division of AIDS, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Korea.
authors.forename: Jee Eun
authors.initials: JE
authors.lastname: Rhee
authors.forename: Mi Yeong
authors.initials: MY
authors.lastname: Shin
authors.forename: Choong Mo
authors.initials: CM
authors.lastname: Kim
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Kee
authors.forename: Jae Keun
authors.initials: JK
authors.lastname: Chung
authors.forename: Sang-Kee
authors.initials: SK
authors.lastname: Min
authors.forename: Seong-Joon
authors.initials: SJ
authors.lastname: Kim
authors.forename: Dai-Ho
authors.initials: DH
authors.lastname: Jang
authors.forename: Sung Soon
authors.initials: SS
authors.lastname: Kim
authors.forename: Byeong-Sun
authors.initials: BS
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D053918:Papillomavirus Vaccines / Q000276:immunology; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D053918:Papillomavirus Vaccines