title: Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits.
abstract: Sixty-two codeine-prescribed breastfeeding mothers from a pharmacogenetic study were interviewed regarding the communication of individual CYP2D6 genotype results and overall research findings. All participants wanted to receive the results of their individual genetic tests; however, individuals placed different values on the usefulness of this information toward future medical decisions. Receiving one's pharmacogenetic test results was not associated with a negative psychosocial impact. Thirty-three percent of the participants wished to withhold these results from their physicians. Participants' expectations seem to dictate the extent of transparency of pharmacogenetic research results.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Madadi
authors.forename: Y
authors.initials: Y
authors.lastname: Joly
authors.forename: D
authors.initials: D
authors.lastname: Avard
authors.forename: D C
authors.initials: DC
authors.lastname: Chitayat
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: C J D
authors.initials: CJ
authors.lastname: Ross
authors.forename: B C
authors.initials: BC
authors.lastname: Carleton
authors.forename: M R
authors.initials: MR
authors.lastname: Hayden
authors.forename: G
authors.initials: G
authors.lastname: Koren
mesh_terms: D000328:Adult; D001942:Breast Feeding / Q000009:adverse effects / Q000523:psychology; D003061:Codeine / Q000009:adverse effects* / Q000378:metabolism; D015331:Cohort Studies; D003142:Communication; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods / Q000523:psychology; D006801:Humans; D007231:Infant, Newborn; D057240:Patient Preference / Q000523:psychology; D010465:Perception; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends; D010865:Pilot Projects; D011369:Professional-Patient Relations; D011795:Surveys and Questionnaires
chemical_list: D019389:Cytochrome P-450 CYP2D6; D003061:Codeine