Antifungal activities of some indole derivatives.
Nine indole derivatives were evaluated in vitro against Fusarium graminearum, Alternaria alternata, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp. cucumarinum, and Alternaria brassicae. Most of the compounds were found to possess antifungal activities. Especially compounds 2, 5, 8, and 9 exhibited broad-spectrum antifungal activities against the above-mentioned seven phytopathogenic fungi, and showed more potent activities than hymexazole, a commercial agricultural fungicide.
Xu
Hui
H
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A & F University, Yangling 712100, PR China. orgxuhui@nwsuaf.edu.cn
Wang
Qin
Q
Yang
Wen-Bin
WB
D000528:Alternaria / Q000187:drug effects*; D000935:Antifungal Agents / Q000494:pharmacology*; D050197:Atherosclerosis / Q000188:drug therapy; D005670:Fusarium / Q000187:drug effects*; D006375:Helminthosporium / Q000187:drug effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055685:Pyricularia grisea / Q000187:drug effects; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D000960:Hypolipidemic Agents; D007211:Indoles