title: Psychiatric symptoms associated with focal hand dystonia.
abstract: Myoclonus dystonia and idiopathic dystonia are associated with a greater frequency of obsessive compulsive disorder (OCD) and major depression. We investigated the frequency of OCD in 39 patients with primary focal hand dystonia (FHD) using a semistructured interview. OCD and subsyndromal OCD was diagnosed in 5 of 39 (12.82%) patients with FHD, whereas OCD occurs in 2.3% of the general population. Recurrent depression occurred in (7 of 39) 17.95% of patients with FHD along with a family history of depression in (16 of 39) 41.02%. Overlapping mechanisms manifesting as FHD may also predispose to OC symptoms and likely implicates a common striatal dysfunction.
authors.affiliation: Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK. voonv@gmail.com
authors.forename: Valerie
authors.initials: V
authors.lastname: Voon
authors.forename: Tracy R
authors.initials: TR
authors.lastname: Butler
authors.forename: Vindhya
authors.initials: V
authors.lastname: Ekanayake
authors.forename: Cecile
authors.initials: C
authors.lastname: Gallea
authors.forename: Rezvan
authors.initials: R
authors.lastname: Ameli
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Murphy
authors.forename: Mark
authors.initials: M
authors.lastname: Hallett
mesh_terms: D000328:Adult; D003863:Depression / Q000209:etiology*; D020821:Dystonic Disorders / Q000150:complications* / Q000473:pathology*; D005260:Female; D006225:Hand / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000209:etiology*; D011569:Psychiatric Status Rating Scales