title: K+(ATP) channels-independent analgesic action of Crotalus durissus cumanensis venom.
abstract: The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 microg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 microg/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinociceptive mechanism of CDCM.
authors.affiliation: Department of Pharmacy, Federal University of Ceara, Fortaleza, Ceara, Brazil.
authors.forename: Ticiana Praciano
authors.initials: TP
authors.lastname: Pereira
authors.forename: Adriana Rolim
authors.initials: AR
authors.lastname: Campos
authors.forename: Luzia Kalyne A M
authors.initials: LK
authors.lastname: Leal
authors.forename: Taiana Magalhães
authors.initials: TM
authors.lastname: Pierdoná
authors.forename: Marcos H
authors.initials: MH
authors.lastname: Toyama
authors.forename: Helena Serra Azul
authors.initials: HS
authors.lastname: Monteiro
authors.forename: Alice Maria Costa
authors.initials: AM
authors.lastname: Martins
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D017839:Crotalus / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology; D054086:KATP Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D012910:Snake Venoms / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D054086:KATP Channels; D026902:Potassium Channel Blockers; D012910:Snake Venoms; D005905:Glyburide