title: [Solar elastosis in cutaneous squamous cell carcinoma].
abstract: BACKGROUND
  Solar elastosis, or basophilic degeneration of collagen, may be a histologic sign of chronic sun damage.
  
  
  METHODS
  We reviewed 222 cases of squamous cell carcinoma (SCC) to identify the presence of solar elastosis and its possible invasion of the upper, middle, or deep reticular dermis. We also analyzed clinical variables such as SCC location, location in exposed areas of the skin, age, sex, and immunosuppression. Patients included had undergone surgical excision of an SCC.
  
  
  RESULTS
  Severe solar elastosis was found in most cases (182 patients, 82%): 87 extended to the middle reticular dermis and 95 had reached the deep reticular dermis. Only 6 (2.7%) patients had no solar elastosis. In some cases elastosis was so severe that it had affected the subcutaneous cellular tissue or venous or arteriolar walls. Deeper solar elastosis was significantly associated with older age and female sex.
  
  
  CONCLUSIONS
  Solar elastosis was found in most patients with SCC and seems to indicate chronic severe solar damage. Exposure to ultraviolet radiation would be the main cause of SCC, although other factors might also be implicated, particularly in patients who did not have severe solar elastosis. Systemic or localized immunosuppression was associated with nearly all the SCC cases studied, consistent with the marked immunosuppressant effects of sun exposure, the aging process, or both.
authors.affiliation: Servicio Dermatología, Hospital Universitario Virgen de la Arrixaca, Murcia, España. raulcorb@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Corbalán-Vélez
authors.forename: J A
authors.initials: JA
authors.lastname: Ruiz-Macia
authors.forename: C
authors.initials: C
authors.lastname: Brufau
authors.forename: I
authors.initials: I
authors.lastname: Oviedo-Ramírez
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Barba
authors.forename: J M
authors.initials: JM
authors.lastname: López-Lozano
authors.forename: F J
authors.initials: FJ
authors.lastname: Carapeto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003094:Collagen; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D003094:Collagen