title: Esomeprazole-induced photoallergic dermatitis.
abstract: There are no published case reports of esomeprazole-induced photoallergic dermatitis. We report here a 58-year-old lady with prior history of propylthiouracil and carbimazole-induced photoallergy, who presented with heartburn and dysphagia. She was diagnosed to have erosive esophagitis and was treated with esomeprazole, following which she developed photoallergic dermatitis. It improved on cessation of the drug and did not recur on subsequent treatment with ranitidine. Naranjo score for this adverse drug event was 8, thereby making it a probable adverse drug reaction. This reaction may be due to sulphur moiety, which is common to all these drugs. Physicians must be aware of this possible side-effect, especially in patients with prior history of photoallergy to other drugs.
authors.affiliation: Department of Gastroenterology,Seth GS Medical College & KEM Hospital, Mumbai, India. akashshukla@kem.edu
authors.forename: A
authors.initials: A
authors.lastname: Shukla
authors.forename: A
authors.initials: A
authors.lastname: Mahapatra
authors.forename: N
authors.initials: N
authors.lastname: Gogtay
authors.forename: U
authors.initials: U
authors.lastname: Khopkar
mesh_terms: D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D017454:Dermatitis, Photoallergic / Q000209:etiology*; D064098:Esomeprazole / Q000009:adverse effects*; D005260:Female; D006356:Heartburn / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D011899:Ranitidine; D064098:Esomeprazole