title: Alsmaphorazines A and B, novel indole alkaloids from Alstonia pneumatophora.
abstract: Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), and their structures were determined on the basis of the 2D NMR and MS spectral analysis. These alkaloids possessed a new skeleton consisting of an 1,2-oxazinane and an isoxazolidine chromophore. The absolute configuration of alsmaphorazine B was determined by using CD spectral analysis. Alsmaphorazine A inhibited the NO production in the LPS-stimulated J774.1 cells dose-dependently without affecting the cell viability.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku,Tokyo 142-8501, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Koyama
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Teh Chin
authors.initials: TC
authors.lastname: Hoe
authors.forename: Kit-Lam
authors.initials: KL
authors.lastname: Chan
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D026121:Indole Alkaloids; C554256:alsmaphorazine A; C554257:alsmaphorazine B