Lycopene and ellagic acid prevent testicular apoptosis induced by cisplatin.
The aim of this study was to investigate the possible protective effects of lycopene (LC) and ellagic acid (EA) on cisplatin (CP)-induced testicular apoptosis in male rats. The control group was treated with placebo; LC, EA and CP groups were given alone LC, EA and CP, respectively; the CP+LC group was treated with a combination of CP and LC; and the CP+EA group was treated with a combination of CP and EA. Although CP significantly increased the number of Bax-positive (apoptotic) cells it had no effect on the number of Bcl-2-positive (antiapoptotic) cells compared with the control group. Administration of CP caused significant increase in lipid peroxidation and nonsignificant decrease in superoxide dismutase (SOD) activity along with some histopathological lesions in testicular tissue. However, combined treatments of LC or EA in addition to CP tended to prevent the CP-induced testicular apoptosis, histopathological lesions and lipid peroxidation.
Türk
Gaffari
G
Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey. gturk@firat.edu.tr
Ceribaşı
Ali Osman
AO
Sahna
Engin
E
Ateşşahin
Ahmet
A
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002338:Carotenoids / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D004610:Ellagic Acid / Q000494:pharmacology*; D006801:Humans; D007150:Immunohistochemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D013737:Testis / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D017392:Thiobarbituric Acid Reactive Substances; D004610:Ellagic Acid; D002338:Carotenoids; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D002945:Cisplatin; D000077276:Lycopene