title: Infiltrants inhibit progression of natural caries lesions in vitro.
abstract: To define the optimized material properties of caries-infiltrating resins (infiltrants), we evaluated the effects of infiltrant composition and penetration coefficient (PC) on the inhibition of the progression of natural approximal caries lesions in vitro. Non-cavitated natural enamel lesions were etched (15% HCl gel) and infiltrated for 5 min with experimental resins varying in PC (cm/sec): PC63, PC185, PC204, and PC391. As a positive control (PosC), lesions were covered with flowable composite resin, whereas untreated lesions served as negative controls (NegC). Specimens were exposed to a demineralizing solution (pH 4.95) for 400 days. Progression of mineral loss was analyzed by transverse wavelength-independent microradiography. Percentage progressions of NegC [median (25th/75th percentile), 24 (10/56)], PC63 [9 (3/39)], and PC185 [12 (9/24)] were significantly higher compared with those of PosC [1 (-8/8)], PC204 [-2 (-4/2)], and PC391 [0 (-5/9)] (p < 0.05). Thus, infiltrants with PC > 200 cm/sec are capable of inhibiting lesion progression.
authors.affiliation: Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrechts-Universität zu Kiel, Arnold-Heller-Str. 3, Haus 26, 24105 Kiel, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Paris
authors.forename: H
authors.initials: H
authors.lastname: Meyer-Lueckel
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry; D003188:Composite Resins / Q000737:chemistry*; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D003743:Dental Enamel / Q000648:ultrastructure; D003764:Dental Materials / Q000737:chemistry*; D018450:Disease Progression; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D008852:Microradiography; D008903:Minerals / Q000032:analysis; D010539:Permeability; D010756:Phosphoric Acids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D013997:Time Factors; D017001:Tooth Demineralization / Q000473:pathology / Q000517:prevention & control
chemical_list: D003188:Composite Resins; D003764:Dental Materials; C420130:Excite cement; D008689:Methacrylates; D008903:Minerals; D010756:Phosphoric Acids; D011109:Polymethacrylic Acids; C452226:tetric flow composite resin; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; C030242:phosphoric acid; D006851:Hydrochloric Acid