title: [Endothelial dysfunction in urolithiasis patients].
abstract: To characterize endothelial dysfunction in operated nephrolithiasis patients, we studied NO, VEGF, ET-1, IL-6 concentration in the blood serum and NO in the urine of nephrolithiasis patients divided into three groups by the type of surgical treatment before operation, 7-10 days and 1 month after it. We used beta-2 microglobulin as an indicator of tubular dysfunction. We found a significant rise of a concentration of the endothelial dysfunction markers ET-1, IL-6 and VEGF in the blood serum (p < 0.05), showing endothelial dysfunction in nephrolithiasis patients, especially in early postoperative period after multiple exposure to short-wave lithotripsy. One month after open surgery or lithotripsy a complete recovery of endothelial function was not recorded.
authors.forename: P V
authors.initials: PV
authors.lastname: Glybochko
authors.forename: A A
authors.initials: AA
authors.lastname: Svistunov
authors.forename: A N
authors.initials: AN
authors.lastname: Rossolovskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Ponukalin
authors.forename: N B
authors.initials: NB
authors.lastname: Zakharova
authors.forename: B I
authors.initials: BI
authors.lastname: Bliumberg
authors.forename: O L
authors.initials: OL
authors.lastname: Berezinets
mesh_terms: D000328:Adult; D019332:Endothelin-1 / Q000097:blood*; D004727:Endothelium / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood* / Q000652:urine; D013997:Time Factors; D052878:Urolithiasis / Q000097:blood* / Q000601:surgery / Q000652:urine; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D019332:Endothelin-1; C508600:IL6 protein, human; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D009569:Nitric Oxide