title: Cisplatin plus Docetaxel Chemotherapy for Thoracic Lymph Node Metastasis from Cancer of Unknown Primary - Experience of Three Cases.
abstract: The optimal chemotherapeutic regimen for cancer of unknown primary (CUP) remains uncertain. We encountered 3 cases with CUP who presented with thoracic lymph node metastasis. Detailed physical examination and diagnostic tests, including laboratory investigations, bronchoscopy, upper and lower gastrointestinal studies, computed tomography of the head, neck, abdomen and pelvis and (18)F-fluorodeoxyglucose positron emission tomography, failed to identify the primary site in these cases. The patients were treated with the cisplatin plus docetaxel chemotherapy regimen. Concomitant thoracic radiotherapy was conducted in one patient and surgical resection in another. All patients showed good response to the chemotherapy and achieved long-term disease-free survival.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kitaguchi
authors.forename: Orie
authors.initials: O
authors.lastname: Hatayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
authors.forename: Takayuki
authors.initials: T
authors.lastname: Honda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Oguchi