title: Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.
abstract: Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.
authors.affiliation: Department of Sexual Health and HIV Medicine, Directorate of Infection, Birmingham Heartlands Hospital, Birmingham, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Taylor
authors.forename: Ashini N
authors.initials: AN
authors.lastname: Jayasuriya
authors.forename: Amanda
authors.initials: A
authors.lastname: Berry
authors.forename: Gerry
authors.initials: G
authors.lastname: Gilleran
authors.forename: Ngozi E
authors.initials: NE
authors.lastname: Dufty
authors.forename: Laura
authors.initials: L
authors.lastname: Else
authors.forename: David J
authors.initials: DJ
authors.lastname: Back
authors.forename: Erasmus J
authors.initials: EJ
authors.lastname: Smit
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000378:metabolism*; D000069454:Darunavir; D004352:Drug Resistance, Microbial; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000821:virology*; D013449:Sulfonamides / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D013449:Sulfonamides; D000069454:Darunavir