title: Outcomes in total elbow arthroplasty in patients with haemophilia at the University of California, San Francisco: a retrospective review.
abstract: Severe haemophilic arthropathy of the elbow is a significant cause of morbidity among adults with haemophilia. However, previous reports of total elbow arthroplasty (TEA) in the haemophilic population have been based on small numbers of patients with relatively short-term follow-up. The records of seven total elbow arthroplasties in six adult men with haemophilia at the University of California, San Francisco who underwent TEA over a period of 25 years were retrospectively reviewed. Type of haemophilia, age at time of TEA, HIV infection status, pre- and postoperative range-of-motion (ROM) scores, complications (including infections), need for subsequent surgical revision and functional outcomes were recorded. Four patients had severe factor VIII deficiency and two patients had severe factor IX deficiency. None of the patients had an inhibitor. The mean age at the time of surgery was 34 years (range, 22-46 years) and the mean follow-up period was 118 months (range, 37-176 months). One of the six patients had TEA in both elbows. Five of the six patients were infected with HIV. There were no immediate perioperative complications. At a mean of 19.2 months postoperatively, ROM had improved in five of seven TEAs: mean flexion had increased from 110.7° (SD = 15.0) to 120.1° (SD = 14.5), whereas mean preoperative extension increased from -44.3° (SD = 21.5) to -36.9° (SD = 27.0). One patient required a revision at 30 months because of ulnar component loosening. This same patient sustained a staph epidermidis infection and ultimate removal of the prosthesis 15 years postoperatively. At a mean of 118 months postoperatively, five of six patients continued to report reduced pain and preserved functionality, with ability to perform normal daily activities. TEA resulted in favourable results in six of seven procedures. Our findings support the viability of TEA for individuals with severe haemophilic arthropathy of the elbow, especially to reduce pain and preserve or restore functionality.
authors.affiliation: Adult Comprehensive Hemophilia Treatment Center, University of California, San Francisco, CA 94143-0106, USA.
authors.forename: M
authors.initials: M
authors.lastname: Marshall Brooks
authors.forename: P
authors.initials: P
authors.lastname: Tobase
authors.forename: S
authors.initials: S
authors.lastname: Karp
authors.forename: D
authors.initials: D
authors.lastname: Francis
authors.forename: P F
authors.initials: PF
authors.lastname: Fogarty
mesh_terms: D000328:Adult; D057929:Arthroplasty, Replacement, Elbow; D006467:Hemophilia A / Q000503:physiopathology / Q000601:surgery*; D002836:Hemophilia B / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010147:Pain Measurement; D011183:Postoperative Complications; D016059:Range of Motion, Articular; D012189:Retrospective Studies; D055815:Young Adult