title: Clinical significance of runt-related transcription factor 1 polymorphism in prostate cancer.
abstract: OBJECTIVE
  To investigate the association of RUNX1 rs2253319 with clinicopathological characteristics of prostate cancer (PCa) and disease recurrence after radical prostatectomy (RP).
  
  
  METHODS
  Taking advantage of the systematic stage and grade for each tumor in a cohort of 314 patients with localized PCa receiving RP, we evaluated the associations of RUNX1 rs2253319 with age at diagnosis, preoperative prostate-specific antigen (PSA) level, Gleason score, surgical margin, pathologic stage, status of lymph node metastasis, and PSA recurrence after RP.
  
  
  RESULTS
  The minor allele, T, and the minor homozygote TT genotype of RUNX1 rs2253319 were significantly associated with a 1.49- to 2.76-fold higher risk for advanced pathologic stage and a 3.35- to 9.52-fold higher risk for lymph node metastasis. RUNX1 rs2253319 TT genotype was also associated with poorer PSA-free survival compared with the major homozygote CC genotype in Kaplan-Meier analysis (log-rank test, P= 0.038) and multivariate Cox proportional hazards model adjusting for age and PSA concentration (P= 0.045).
  
  
  CONCLUSIONS
  RUNX1 rs2253319 is associated with adverse clinicopathological features and might be a prognostic factor for the recurrence of PSA in patients with PCa receiving RP.
authors.affiliation: Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, China.
authors.forename: Shu-Pin
authors.initials: SP
authors.lastname: Huang
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Lan
authors.forename: Te-Ling
authors.initials: TL
authors.lastname: Lu
authors.forename: Jiunn-Bey
authors.initials: JB
authors.lastname: Pao
authors.forename: Ta-Yuan
authors.initials: TY
authors.lastname: Chang
authors.forename: Hong-Zin
authors.initials: HZ
authors.lastname: Lee
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Yang
authors.forename: Chi-Jeng
authors.initials: CJ
authors.lastname: Hsieh
authors.forename: Lu-Min
authors.initials: LM
authors.lastname: Chen
authors.forename: Li-Chia
authors.initials: LC
authors.lastname: Huang
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Ting
authors.forename: Bo-Ying
authors.initials: BY
authors.lastname: Bao
mesh_terms: D000368:Aged; D000483:Alleles; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D004812:Epidemiologic Methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit