[Study of phosphorylated ERK1/2 on nasal polyps].
OBJECTIVE
To study the expression of phosphorylated extracellular regulator kinase (ERK1/2) on nasal polyps.


METHODS
The immunohistochemistry and Western-blot were used to study the phosphorylation of ERK1/2 on the normal nasal mucosa and nasal polyps.


RESULTS
The phosphorylated ERK1/2 was mainly expressed on the hyperplastic epithelium, inflammatory cells, glandular epithelium and endothelium of nasal polyps by immunohistochemistry, which was much stronger on nasal polyps than that of normal mucosa. The expression of phosphorylated ERK1/2 was 4.2 times than that of normal mucosa.


CONCLUSIONS
The study indicated that the phosphorylation of ERK1/2 might play an important role on the occurrence and progression of nasal polyps.
Wang
Tiansheng
T
Department of Otolaryngology,the Third Xiangya Hospital,Central South University, Changsha, 410013, China. tswheaven@hotmail.com
Chu
Ling
L
Chen
Jiangbo
J
Chen
Yu
Y
Liu
Gengsheng
G
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D009298:Nasal Polyps / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D055815:Young Adult
C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3