1,1-Dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles.
The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.
Berciano
Beatriz Pacheco
BP
Univ Paris-Sud, Orsay F-91405, France.
Lebrequier
Sabrina
S
Besselièvre
François
F
Piguel
Sandrine
S
D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001393:Azoles / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure
D000475:Alkenes; D000480:Alkynes; D001393:Azoles; D017605:Bromine Compounds; D006571:Heterocyclic Compounds; D003300:Copper