title: In vitro assessment of apheresis and pooled buffy coat platelet components suspended in plasma and SSP+ photochemically treated with amotosalen and UVA for pathogen inactivation (INTERCEPT Blood System™).
abstract: OBJECTIVE
  INTERCEPT Blood System™ is a pathogen inactivation system for blood components. The initial approval required a platelet component to be suspended in a combination of plasma and Platelet additive Solution/PAS-III. Improved platelet storage has been reported with Mg++ and K+ supplementation (PAS-IIIM). This study validated the use of INTERCEPT™/PAS-IIIM for apheresis and pooled buffy-coat platelet components.
  
  
  METHODS
  The platelet dose and pH throughout 5 days of storage met the European and French requirements for quality standards.
  
  
  CONCLUSIONS
  Additional metabolic and activation assessments of the treated platelets confirmed the previously reported superiority of PAS-IIIM over PAS-III, but extended it to the INTERCEPT™ process.
authors.affiliation: EFS Auvergne Loire, Saint- Etienne, France.
authors.forename: P
authors.initials: P
authors.lastname: Chavarin
authors.forename: F
authors.initials: F
authors.lastname: Cognasse
authors.forename: C
authors.initials: C
authors.lastname: Argaud
authors.forename: M
authors.initials: M
authors.lastname: Vidal
authors.forename: C
authors.initials: C
authors.lastname: De Putter
authors.forename: F
authors.initials: F
authors.lastname: Boussoulade
authors.forename: C
authors.initials: C
authors.lastname: Ripaud
authors.forename: S
authors.initials: S
authors.lastname: Acquart
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: O
authors.initials: O
authors.lastname: Garraud
mesh_terms: D001781:Blood Component Removal; D001792:Blood Platelets; D001793:Blood Preservation; D004203:Disinfection / Q000295:instrumentation / Q000379:methods; D005260:Female; D011564:Furocoumarins / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D011564:Furocoumarins; C118577:amotosalen