title: Assessment of antinociceptive, anti-inflammatory and antioxidant properties of Cymbopogon winterianus leaf essential oil.
abstract: The present study investigated the antinociceptive, anti-inflammatory and antioxidant effects of the leaf essential oil (LEO) of Cymbopogon winterianus Jowitt (Poaceae). In the acetic acid-induced writhing and formalin tests, the LEO (50, 100, and 200 mg/kg, p.o.) significantly reduced (p < 0.05) the number of writhings and paw licking times in the first (0-5 min) and second (15-30 min) phases, respectively. In contrast, the LEO did not alter the latency time for mice licking the rear paws in hot-plate test. The LEO inhibited the carrageenan-induced neutrophil migration to the peritoneal cavity in a dose-dependent manner (35.5%, 42.8%, and 66.1% at doses of 50, 100, and 200 mg/kg, respectively, p < 0.001). Moreover, LEO exhibited higher scavenging activity toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with an IC(50) (12.66 ± 0.56 μg/mL). Our present results demonstrated that the LEO has antinociceptive, anti-inflammatory, and antioxidant properties.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, Campus Universitário Prof. Aloísio de Campos, São Cristóvão, SE, Brazil.
authors.forename: Bárbara L S
authors.initials: BL
authors.lastname: Leite
authors.forename: Rangel R
authors.initials: RR
authors.lastname: Bonfim
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Sara M
authors.initials: SM
authors.lastname: Thomazzi
authors.forename: Adriano A S
authors.initials: AA
authors.lastname: Araújo
authors.forename: Arie F
authors.initials: AF
authors.lastname: Blank
authors.forename: Charles S
authors.initials: CS
authors.lastname: Estevam
authors.forename: Erica V F
authors.initials: EV
authors.lastname: Cambui
authors.forename: Leonardo R
authors.initials: LR
authors.lastname: Bonjardim
authors.forename: Ricardo L C
authors.initials: RL
authors.lastname: Albuquerque Júnior
authors.forename: Lucindo J
authors.initials: LJ
authors.lastname: Quintans-Júnior
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002351:Carrageenan; D031743:Cymbopogon / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D009822:Oils, Volatile; D010851:Picrates; D010938:Plant Oils; D002351:Carrageenan; C004931:1,1-diphenyl-2-picrylhydrazyl; D019342:Acetic Acid