[The possible mechanisms of acetylcholine receptor desensitization].
The postsynaptic mechanisms initiating the development of two acetylcholine receptor states (I and D) which determine the desensitization are discussed. Attention is focused on the processes of receptor endocytosis as the major mechanism of desensitization. General processes and differences in the development of the D state during the desensitization and long-term depression are analyzed. A mathematical model taking into account the membrane and intracellular receptor states is used. This model makes it possible to analyze the influence of some intracellular substances on the receptor internalization and recycling.
Murzina
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D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D021381:Protein Transport; D011950:Receptors, Cholinergic / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology
D002352:Carrier Proteins; D011950:Receptors, Cholinergic; D000109:Acetylcholine