title: One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.
abstract: An efficient microwave-assisted one-pot two-step protocol was developed for the construction of disubstituted 2-amino-1H-imidazoles. This process involves the sequential formation of 2,3-dihydro-2-hydroxyimidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and α-bromoketones, followed by cleavage of the pyrimidine ring with hydrazine.
authors.affiliation: Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.
authors.forename: D S
authors.initials: DS
authors.lastname: Ermolat'ev
authors.forename: B
authors.initials: B
authors.lastname: Savaliya
authors.forename: A
authors.initials: A
authors.lastname: Shah
authors.forename: E
authors.initials: E
authors.lastname: Van der Eycken
mesh_terms: D002384:Catalysis / Q000528:radiation effects*; D002621:Chemistry / Q000379:methods*; D006358:Hot Temperature; D007093:Imidazoles / Q000138:chemical synthesis*; D008872:Microwaves; D011743:Pyrimidines / Q000737:chemistry
chemical_list: D007093:Imidazoles; D011743:Pyrimidines; C012180:2-aminopyrimidine; C014973:2-aminoimidazole