title: Antimicrobial and anticancer efficacy of antineoplastic agent capped gold nanoparticles.
abstract: Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E. coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.
authors.affiliation: Department of Chemistry, University College of Engineering-Villupuram, Anna University Chennai, Chennai 600025, India.
authors.forename: V
authors.initials: V
authors.lastname: Selvaraj
authors.forename: A Nirmala
authors.initials: AN
authors.lastname: Grace
authors.forename: M
authors.initials: M
authors.lastname: Alagar
authors.forename: I
authors.initials: I
authors.lastname: Hamerton
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D003102:Colloids / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013866:Thioguanine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003102:Colloids; D006046:Gold; D013866:Thioguanine