title: Current development of saliva/oral fluid-based diagnostics.
abstract: Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.
authors.affiliation: Department of Dental Diagnostic Science, University of Texas Health Science Center at San Antonio, USA.
authors.forename: Chih-Ko
authors.initials: CK
authors.lastname: Yeh
authors.forename: Nicolaos J
authors.initials: NJ
authors.lastname: Christodoulides
authors.forename: Pierre N
authors.initials: PN
authors.lastname: Floriano
authors.forename: Craig S
authors.initials: CS
authors.lastname: Miller
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Ebersole
authors.forename: Shannon E
authors.initials: SE
authors.lastname: Weigum
authors.forename: John
authors.initials: J
authors.lastname: McDevitt
authors.forename: Spencer W
authors.initials: SW
authors.lastname: Redding
mesh_terms: D015415:Biomarkers / Q000032:analysis; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D056656:Lab-On-A-Chip Devices; D012463:Saliva / Q000737:chemistry* / Q000166:cytology / Q000502:physiology
chemical_list: D015415:Biomarkers