Illicit drug use and risk for USA300 methicillin-resistant Staphylococcus aureus infections with bacteremia.
To assess the association of illicit drug use and USA300 methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, a multicenter study was conducted at 4 Veterans Affairs medical centers during 2004-2008. The study showed that users of illicit drugs were more likely to have USA300 MRSA bacteremia (in contrast to bacteremia caused by other S. aureus strains) than were patients who did not use illicit drugs (adjusted relative risk 3.0; 95% confidence interval 1.9-4.4). The association of illicit drug use with USA300 MRSA bacteremia decreased over time (p = 0.23 for trend). Notably, the proportion of patients with USA300 MRSA bacteremia who did not use illicit drugs increased over time. This finding suggests that this strain has spread from users of illicit drugs to other populations.
Kreisel
Kristen M
KM
Department of Epidemiology and Preventive Medicine, University of Maryland Baltimore, Baltimore, MD 21201, USA. kris03222001@yahoo.com
Johnson
J Kristie
JK
Stine
O Colin
OC
Shardell
Michelle D
MD
Perencevich
Eli N
EN
Lesse
Alan J
AJ
Gordin
Fred M
FM
Climo
Michael W
MW
Roghmann
Mary Claire
MC
D000368:Aged; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000635:transmission; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology / Q000635:transmission; D058872:Epidemics; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D008875:Middle Aged; D017720:Molecular Epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000635:transmission; D019966:Substance-Related Disorders / Q000150:complications*; D014481:United States / Q000453:epidemiology