title: Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis.
abstract: OBJECTIVE
  To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU).
  
  
  METHODS
  Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI.
  
  
  RESULTS
  Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index.
  
  
  CONCLUSIONS
  Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.
authors.affiliation: Department of Internal Medicine, Hôtel Dieu, Hospices Civils de Lyon, and University Claude Bernard Lyon 1, Lyon, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Le Roux
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.forename: Romain
authors.initials: R
authors.lastname: Marignier
authors.forename: Julien
authors.initials: J
authors.lastname: Bancel
authors.forename: Christiane
authors.initials: C
authors.lastname: Broussolle
authors.forename: Pascal
authors.initials: P
authors.lastname: Sève
mesh_terms: D000328:Adult; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D043025:Oligoclonal Bands / Q000276:immunology; D012189:Retrospective Studies; D013116:Spinal Cord / Q000276:immunology; D013129:Spinal Puncture; D015867:Uveitis, Intermediate / Q000276:immunology*; D055815:Young Adult
chemical_list: D007136:Immunoglobulins; D043025:Oligoclonal Bands