title: Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma.
abstract: We present a unique case of bilateral gonadoblastoma in a 23-year-old patient with Swyer syndrome. The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one. The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion. Most probably, the pathogenesis of this abdominal dissemination was iatrogenic, with implantation occurring mechanically as a result of the multiple laparoscopic biopsies performed on both of the streak gonads 2 months before the abdominal surgery. The pathogenesis of other benign abdominal implants is discussed.
authors.affiliation: Department of Pathology and Obstetrics and Gynecology, Università degli Studi di Sassari, Sardinia, Italy.
authors.forename: Giovanna A
authors.initials: GA
authors.lastname: Onida
authors.forename: Luisanna
authors.initials: L
authors.lastname: Bosincu
authors.forename: Salvatore
authors.initials: S
authors.lastname: Dessole
authors.forename: Alina
authors.initials: A
authors.lastname: Nicolae
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Preda
authors.forename: Paolo
authors.initials: P
authors.lastname: Cossu-Rocca
authors.forename: Jose
authors.initials: J
authors.lastname: Aneiros-Fernandez
authors.forename: Francisco F
authors.initials: FF
authors.lastname: Nogales
mesh_terms: D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications / Q000473:pathology; D018238:Gonadoblastoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology*; D010537:Peritoneum / Q000473:pathology; D012707:Sertoli Cell Tumor / Q000150:complications / Q000473:pathology*; D014565:Urogenital Neoplasms / Q000150:complications / Q000473:pathology*; D055815:Young Adult