Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs.
The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN). It was found that SN-1 targeted trophozoites and had a synergistic effect when combined with CQ and QN; however, it had an antagonist effect when used with the other combinations.
Pabón
Adriana
A
Malaria Group, Universidad de Antioquia, Medellín, Colombia.
Deharo
Eric
E
Blair
Silvia
S
D000655:Amodiaquine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000962:Antimalarials / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D037621:Artemisinins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D053626:Atovaquone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004357:Drug Synergism; D004912:Erythrocytes / Q000469:parasitology; D005434:Flow Cytometry; D006801:Humans; D010840:Phytosterols / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D032322:Solanum / Q000737:chemistry*; D053058:Trophozoites / Q000187:drug effects
D000962:Antimalarials; D037621:Artemisinins; D010840:Phytosterols; D000655:Amodiaquine; C047386:desethylamodiaquine; D002738:Chloroquine; C031327:artemisinin; D011803:Quinine; D053626:Atovaquone