title: Amelanotic Anorectal Malignant Melanoma: Case Report with Immunohistochemical Study and Literature Review.
abstract: Epithelioid cell tumors presenting in the gastrointestinal tract are uncommon, but when they arise, arriving at a correct diagnosis is important. We report a case of anal malignant melanoma in an 82-year-old man who microscopically showed an epithelioid malignant tumor simulating a gastrointestinal stromal tumor. C-kit stain and Melan-A were diffusely and strongly positive, while HMB-45 was focally positive. This case illustrates the potential pitfall of relying on a single antibody or inadequate panel of immunohistochemical stains to confirm the diagnosis. We recommend to apply an adequate immunohistochemical panel which includes S-100 protein, HMB-45 and Melan-A in order to make an accurate diagnosis, and discuss the differential diagnosis and surgical treatment modalities.
authors.affiliation: Department of Pathology, Hospital de Dénia, Denia, Spain.
authors.forename: Juan B
authors.initials: JB
authors.lastname: Laforga Canales
authors.forename: Joan M
authors.initials: JM
authors.lastname: Gasent Blesa