1,5-Anhydroglucitol levels are low irrespective of plasma glucose levels in patients with chronic liver disease.
BACKGROUND
Serum 1,5-anhydroglucitol (1,5-AG) is a known marker reflecting recent glycaemic control. In this study, we examined serum 1,5-AG levels in chronic liver disease (CLD) patients with and without diabetes mellitus.


METHODS
Eighty patients with CLD were compared with 667 subjects without CLD. Glycaemic control of the CLD patients was evaluated by estimated glycated haemoglobin (HbA(1C)) calculated using the equation by Rohlfing et al. from mean plasma glucose because CLD patients have apparently low HbA(1C).


RESULTS
When the study participants were divided into subgroups stratified by HbA(1C) levels, the CLD patients whose estimated HbA(1C) levels were less than 7.0% showed significantly lower 1,5-AG than their counterparts of the control subjects. Stepwise multivariable analysis revealed that estimated HbA(1C) was the significant explanatory variable for 1,5-AG in the CLD patients. However, in the CLD patients with estimated HbA(1C) less than 5.8%, only hepaplastin test was the significant explanatory variable for 1,5-AG.


CONCLUSIONS
Serum 1,5-AG levels are low irrespective of plasma glucose levels in the CLD patients with and without diabetes. The CLD patients who had low serum 1,5-AG levels were associated with deteriorated liver function.
Koga
Masafumi
M
Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. koga_m@kich.itami.hyogo.jp
Murai
Jun
J
Saito
Hiroshi
H
Mukai
Mikio
M
Toya
Daishu
D
Tanaka
Nobuyoshi
N
Kanehara
Hideo
H
Bando
Yukihiro
Y
Kasayama
Soji
S
D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D002908:Chronic Disease; D003847:Deoxyglucose / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis
D001786:Blood Glucose; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose