Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer.
Estrogen-dependent breast cancer (EDBC) is a kind of common malignant tumor in postmenopausal women with growing tendency in recent years. Aromatase (AR) is the key enzyme responsible for estrogen biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for EDBC. AR inhibitors (AIs) are divided into steroidal and nonsteroidal compounds, and the latter shows high inhibitory potency against AR. This review summarizes recent advancement in nonsteroidal AIs.
Jiao
J
J
Department of Medicinal Chemistry, College of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, PR China.
Xiang
H
H
Liao
Q
Q
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D001141:Aromatase / Q000737:chemistry* / Q000378:metabolism; D047072:Aromatase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002867:Chromones / Q000737:chemistry / Q000627:therapeutic use; D003374:Coumarins / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D000077289:Letrozole; D009570:Nitriles / Q000737:chemistry / Q000627:therapeutic use; D011960:Receptors, Estrogen / Q000378:metabolism*; D013449:Sulfonamides / Q000737:chemistry / Q000627:therapeutic use; D014230:Triazoles / Q000737:chemistry / Q000627:therapeutic use
D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D002867:Chromones; D003374:Coumarins; D005419:Flavonoids; D009570:Nitriles; D011960:Receptors, Estrogen; D013449:Sulfonamides; D014230:Triazoles; C060523:vorozole; D000077289:Letrozole; C030123:coumarin; D001141:Aromatase; C012655:nimesulide