title: Triterpene saponins from Cyclamen persicum.
abstract: A new triterpene saponin 3-O-beta-D-glucopyranosyl-(1 --> 4)-alpha-L-arabinopyranosyl-16alpha-hydroxy-13beta,28-epoxy-oleanan-30-al (1), along with four known triterpene glycosides (2-5) were isolated from Cyclamen persicum. Their structures were characterized by a combination of 1D- and 2D-NMR (1H-1H COSY, TOCSY, NOESY, HSQC, and HMBC) and MS spectrocopic data. The cytotoxicity of compounds 2 and 4 was evaluated using two human colon cancer cell lines HT-29 and HCT 116.
authors.affiliation: Laboratoire de Pharmacognosie, Unité de Molécules d'Intérĉt Biologique (UMIB UPRES EA 3660), Faculté de Pharmacie, Universitá de Bourgogne, BP 87900, 21079 Dijon Cedex, France.
authors.forename: Ghezala
authors.initials: G
authors.lastname: Mihci-Gaidi
authors.forename: David
authors.initials: D
authors.lastname: Pertuit
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mirjolet
authors.forename: Olivier
authors.initials: O
authors.lastname: Duchamp
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: Marie-Aleth
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D045744:Cell Line, Tumor; D031824:Cyclamen / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000633:toxicity*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D012503:Saponins; D014315:Triterpenes