Synthesis of dibenzo[b,f][1,4]oxazepin-11(10H)-ones via intramolecular cyclocarbonylation reactions using PdI(2)/Cytop 292 as the catalytic system.
The intramolecular cyclocarbonylation of substituted 2-(2-iodophenoxy)anilines was catalyzed by PdI(2) and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phospha-adamantane (Cytop 292) in an efficient manner. A series of substituted dibenzo[b,f][1,4]oxazepin-11(10H)-ones were prepared in good yields under mild reaction conditions.
Yang
Qian
Q
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.
Cao
Hong
H
Robertson
Al
A
Alper
Howard
H
D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010077:Oxazepines / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
C554871:1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phospha-adamantane; D000814:Aniline Compounds; D010077:Oxazepines; D010165:Palladium; D000218:Adamantane