Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials.
Persons living with HIV/AIDS (PLHA) of color are under-represented in AIDS clinical trials (ACTs), which may limit the generalizability of research findings and denies many individuals access to high levels of care and new treatments available through ACTs. Disproportionately low rates of recruitment in health care settings and by providers are a major barrier to ACTs for this group. Moreover, PLHA of color are more likely than their white peers to decline to participate, mainly due to fear and mistrust (although willingness is also high), negative social norms about ACTs, and difficulty navigating the unfamiliar ACT system. We describe a small number of successful behavioral and structural interventions to increase the participation of PLHA of color in screening for and enrollment into ACTs. HIV care settings, clinical trials sites, and trial sponsors are uniquely positioned to develop procedures, supports, and trials to increase the proportion of PLHA of color in ACTs.
Gwadz
Marya Viorst
MV
New York University College of Nursing, 726 Broadway, New York, NY 10003, USA. marya.gwadz@nyu.edu
Colon
Pablo
P
Ritchie
Amanda S
AS
Leonard
Noelle R
NR
Cleland
Charles M
CM
Riedel
Marion
M
Bowens
DeShannon
D
Banfield
Angela D
AD
Chang
Patricia
P
Quiles
Robert
R
Mildvan
Donna
D
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000208:ethnology; D001741:Black or African American; D002986:Clinical Trials as Topic; D005006:Ethnicity; D015658:HIV Infections / Q000188:drug therapy / Q000208:ethnology* / Q000517:prevention & control; D007722:Health Knowledge, Attitudes, Practice; D006297:Health Services Accessibility; D054625:Healthcare Disparities / Q000208:ethnology; D006630:Hispanic or Latino; D006801:Humans; D008913:Minority Groups; D054525:Minority Health; D010349:Patient Compliance; D010358:Patient Participation; D018579:Patient Selection; D045808:Refusal to Participate / Q000208:ethnology; D035502:Trust