title: Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.
abstract: NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.
authors.affiliation: Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Piña-Crespo
authors.forename: Maria
authors.initials: M
authors.lastname: Talantova
authors.forename: Ileana
authors.initials: I
authors.lastname: Micu
authors.forename: Bradley
authors.initials: B
authors.lastname: States
authors.forename: H-S Vincent
authors.initials: HS
authors.lastname: Chen
authors.forename: Shichun
authors.initials: S
authors.lastname: Tu
authors.forename: Nobuki
authors.initials: N
authors.lastname: Nakanishi
authors.forename: Gary
authors.initials: G
authors.lastname: Tong
authors.forename: Dongxian
authors.initials: D
authors.lastname: Zhang
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Heinemann
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Zamponi
authors.forename: Peter K
authors.initials: PK
authors.lastname: Stys
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Lipton
mesh_terms: D000818:Animals; D002460:Cell Line; D002490:Central Nervous System / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D005998:Glycine / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009186:Myelin Sheath / Q000502:physiology*; D021122:Protein Subunits / Q000819:agonists / Q000235:genetics / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000819:agonists / Q000494:pharmacology
chemical_list: C409466:NR1 NMDA receptor; C464437:NR3A NMDA receptor; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinant Proteins; D005998:Glycine