Alsmaphorazines A and B, novel indole alkaloids from Alstonia pneumatophora.
Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), and their structures were determined on the basis of the 2D NMR and MS spectral analysis. These alkaloids possessed a new skeleton consisting of an 1,2-oxazinane and an isoxazolidine chromophore. The absolute configuration of alsmaphorazine B was determined by using CD spectral analysis. Alsmaphorazine A inhibited the NO production in the LPS-stimulated J774.1 cells dose-dependently without affecting the cell viability.
Koyama
Koichiro
K
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku,Tokyo 142-8501, Japan.
Hirasawa
Yusuke
Y
Nugroho
Alfarius Eko
AE
Hosoya
Takahiro
T
Hoe
Teh Chin
TC
Chan
Kit-Lam
KL
Morita
Hiroshi
H
D031051:Alstonia / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D026121:Indole Alkaloids; C554256:alsmaphorazine A; C554257:alsmaphorazine B