Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors.
Uterine neoplasms showing an exclusive sex cord-like differentiation or focal low-grade sarcoma differentiation, designated as uterine tumors resembling ovarian sex cord tumors (UTROSCTs), are rare, with only 48 cases described earlier in international literature. Generally, this entity is characterized by benign behavior. In this study, we report the clinical and pathologic features of 2 peculiar new cases of UTROSCTs. In these examples, the pathologic diagnosis of UTROSCT was made incidentally after the clinical diagnosis of a leiomyoma and endometrial polyp. On examination of small biopsies, the diagnosis was facilitated by specific immunohistochemical analysis using markers for the sex cord component. In 1 of these cases, the patient, because of her young age and her desire to preserve her fertility, was only treated by minimally invasive hysteroscopic surgery. In the other case, the neoplasm seemed to be the consequence of tamoxifen treatment for breast carcinoma. After diagnosis, in this second case, the woman underwent hysterectomy that showed a residue of the tumor and cervical metastasis from the earlier breast carcinoma. The differential diagnosis of UTROSCT and the role of immunohistochemistry in confirming a diagnosis are discussed.
Giordano
Giovanna
G
Department of Pathology and Laboratory Medicine, Pathology Section, University of Parma, Viale A. Gramsci 14, Parma, Italy. giovanna.giordano@unipr.it
Lombardi
Mariano
M
Brigati
Francesca
F
Mancini
Cristina
C
Silini
Enrico Maria
EM
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D018275:Carcinoma, Lobular / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology; D013629:Tamoxifen / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000556:secondary; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen