title: Carrier frequency of GJB2 gene mutations c.35delG, c.235delC and c.167delT among the populations of Eurasia.
abstract: Hearing impairment is one of the most common disorders of sensorineural function and the incidence of profound prelingual deafness is about 1 per 1000 at birth. GJB2 gene mutations make the largest contribution to hereditary hearing impairment. The spectrum and prevalence of some GJB2 mutations are known to be dependent on the ethnic origin of the population. This study presents data on the carrier frequencies of major GJB2 mutations, c.35delG, c.167delT and c.235delC, among 2308 healthy persons from 18 various populations of Eurasia: Russians, Bashkirs, Tatars, Chuvashes, Udmurts, Komi-Permyaks and Mordvins (Volga-Ural region of Russia); Belarusians and Ukrainians (East Europe); Abkhazians, Avars, Cherkessians and Ingushes (Caucasus); Kazakhs, Uighurs and Uzbeks (Central Asia); and Yakuts and Altaians (Siberia). The data on c.35delG and c.235delC mutation prevalence in the studied ethnic groups can be used to investigate the prospective founder effect in the origin and prevalence of these mutations in Eurasia and consequently in populations around the world.
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russian Federation. dzhemilev@anrb.ru
authors.forename: Lilya U
authors.initials: LU
authors.lastname: Dzhemileva
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Barashkov
authors.forename: Olga L
authors.initials: OL
authors.lastname: Posukh
authors.forename: Rita I
authors.initials: RI
authors.lastname: Khusainova
authors.forename: Vita L
authors.initials: VL
authors.lastname: Akhmetova
authors.forename: Ildus A
authors.initials: IA
authors.lastname: Kutuev
authors.forename: Irina R
authors.initials: IR
authors.lastname: Gilyazova
authors.forename: Vera N
authors.initials: VN
authors.lastname: Tadinova
authors.forename: Sardana A
authors.initials: SA
authors.lastname: Fedorova
authors.forename: Irina M
authors.initials: IM
authors.lastname: Khidiyatova
authors.forename: Simeon L
authors.initials: SL
authors.lastname: Lobov
authors.forename: Elza K
authors.initials: EK
authors.lastname: Khusnutdinova
mesh_terms: D001209:Asia, Central / Q000208:ethnology; D044466:Asian People / Q000235:genetics*; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics*; D003638:Deafness / Q000208:ethnology / Q000235:genetics*; D005061:Europe, Eastern / Q000208:ethnology; D005787:Gene Frequency; D006580:Genetic Carrier Screening / Q000379:methods*; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D012426:Russia / Q000208:ethnology; D044465:White People / Q000235:genetics*
chemical_list: D017630:Connexins; C000607042:GJB2 protein, human; D000072259:Connexin 26