Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.
Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.
Klein
Anders Bue
AB
Neurobiology Research Unit, The Neuroscience Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Trajkovska
Viktorija
V
Erritzoe
David
D
Haugbol
Steven
S
Madsen
Jacob
J
Baaré
William
W
Aznar
Susana
S
Knudsen
Gitte M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001596:Benzylamines; D001921:Brain / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005462:Fluorine Radioisotopes; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007650:Ketanserin / Q000031:analogs & derivatives; D008279:Magnetic Resonance Imaging; D008297:Male; D008715:Methionine; D008875:Middle Aged; D019579:Neocortex / Q000378:metabolism; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D049268:Positron-Emission Tomography; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D014633:Valine; D055815:Young Adult
D001596:Benzylamines; D019208:Brain-Derived Neurotrophic Factor; D005462:Fluorine Radioisotopes; C420885:N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine; D044402:Receptor, Serotonin, 5-HT2A; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; C071983:altanserin; D007650:Ketanserin; D008715:Methionine; D014633:Valine