Catalytic intramolecular aromatic C-H alkenylation of arenes with non-activated ketones: synthesis of 4-alkylene quinolin-2-ones.
The catalytic intramolecular aromatic C-H alkenylation of arenes with non-activated ketone carbonyls has been realized for the first time, leading to the synthesis of antiviral 4-alkylene quinolin-2-ones, where the quaternary carbon adjacent to the ketone carbonyl plays an essential role in this catalytic reaction.
Wang
Yeming
Y
Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
Li
Wei-Qi
WQ
Che
Guangbo
G
Bi
Xihe
X
Liao
Peiqiu
P
Zhang
Qian
Q
Liu
Qun
Q
D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry*
D000475:Alkenes; D007659:Ketones; D015363:Quinolones; D002244:Carbon; D006859:Hydrogen