title: Antifungal activities of some indole derivatives.
abstract: Nine indole derivatives were evaluated in vitro against Fusarium graminearum, Alternaria alternata, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp. cucumarinum, and Alternaria brassicae. Most of the compounds were found to possess antifungal activities. Especially compounds 2, 5, 8, and 9 exhibited broad-spectrum antifungal activities against the above-mentioned seven phytopathogenic fungi, and showed more potent activities than hymexazole, a commercial agricultural fungicide.
authors.affiliation: Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A & F University, Yangling 712100, PR China. orgxuhui@nwsuaf.edu.cn
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Yang
mesh_terms: D000528:Alternaria / Q000187:drug effects*; D000935:Antifungal Agents / Q000494:pharmacology*; D050197:Atherosclerosis / Q000188:drug therapy; D005670:Fusarium / Q000187:drug effects*; D006375:Helminthosporium / Q000187:drug effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055685:Pyricularia grisea / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D000960:Hypolipidemic Agents; D007211:Indoles