Neuropsychological effects of macrolides.
Pharmacovigilance data collected from several European countries show that macrolides can provoke neuropsychological adverse effects such as hallucinations, delirium, manic episodes and sometimes depression, in both adults and children. These effects seem to be rare and are reversible on macrolide withdrawal. In practice, keep in mind that if neuropsychological disorders can be attributed to macrolides, treatment should be halted.
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004917:Erythromycin / Q000009:adverse effects; D006801:Humans; D048628:Ketolides / Q000009:adverse effects; D018942:Macrolides / Q000009:adverse effects*; D001523:Mental Disorders / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; C106791:telithromycin