title: The shibire(ts) mutant of Drosophila: a probe for the study of embryonic development.
abstract: A temperature-sensitive mutant strain (shibire) has been used to probe the normal developmental process in Drosophila melanogaster. At high temperatures lethality occurs during embryonic development. Heat pulses given early disrupt cellular blastoderm formation in these mutants. Even in the absence of cells, the embryo begins morphogenetic movements characteristic of gastrulation. With heat pulses given later, the embryonic cells proliferate without normal differentiation.
authors.affiliation: Thimann Laboratories, University of California, Santa Cruz, California 95064, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Swanson
authors.forename: C A
authors.initials: CA
authors.lastname: Poodry
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics*; D034281:Dynamins / Q000235:genetics*; D047108:Embryonic Development; D005260:Female; D046529:Microscopy, Electron, Transmission; D009154:Mutation; D010641:Phenotype
chemical_list: D029721:Drosophila Proteins; D034281:Dynamins; C439628:shi protein, Drosophila