title: The value of apelin-36 and brain natriuretic peptide measurements in patients with first ST-elevation myocardial infarction.
abstract: BACKGROUND
  We aimed to assess apelin-novel endogenous ligand for the angiotensin-like 1 receptor in patients with ST-elevation myocardial infarction (STEMI) and to compare its value with B-type natriuretic peptide (BNP).
  
  
  METHODS
  In 78 consecutive patients with first STEMI treated with primary PCI, plasma apelin-36 (RIA) and BNP (MEIA) concentrations were measured twice: on admission and on the fifth day of hospitalization. Left ventricle ejection fraction (LVEF) was assessed on admission and composite endpoint (CEP)-after 1 year follow-up.
  
  
  RESULTS
  During the 5-day interval median plasma BNP level significantly increased and median plasma apelin concentration significantly decreased. BNP, but not apelin, correlated with low LVEF (<50%). In ROC analysis only BNP measurements were diagnostic for low LVEF. In ANOVA test, in patients with CEP, a significant decrease in apelin (but not BNP) concentrations measured in 5-day interval was found. ROC analysis identified only second BNP measurement as significant to estimate adverse outcome 0.627 in the prediction of CEP (95% confidence interval=0.507-0.736).
  
  
  CONCLUSIONS
  Following STEMI there is a decrease of plasma apelin-36 concentration and an increase of plasma BNP concentration. BNP is better, than apelin diagnostic value for the detection of impaired LVEF. Both BNP and apelin have prognostic value, although both needs further evaluation.
authors.affiliation: Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.tycinska@gmail.com
authors.forename: Agnieszka M
authors.initials: AM
authors.lastname: Tycinska
authors.forename: Bozena
authors.initials: B
authors.lastname: Sobkowicz
authors.forename: Barbara
authors.initials: B
authors.lastname: Mroczko
authors.forename: Robert
authors.initials: R
authors.lastname: Sawicki
authors.forename: Wlodzimierz J
authors.initials: WJ
authors.lastname: Musial
authors.forename: Slawomir
authors.initials: S
authors.lastname: Dobrzycki
authors.forename: Ewa
authors.initials: E
authors.lastname: Waszkiewicz
authors.forename: Malgorzata A
authors.initials: MA
authors.lastname: Knapp
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D000368:Aged; D000073861:Apelin; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000378:metabolism
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D020097:Natriuretic Peptide, Brain