title: The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor.
abstract: The first total synthesis of aspergillusol A, an alpha-glucosidase inhibitor, was accomplished in an overall high yielding reaction sequence. A convergent synthetic approach was adopted; the erythritol segment of the molecule was derived from L-arabinose, whereas hydroxyphenylpyruvic acid oxime was built up from 4-hydroxybenzaldehyde.
authors.affiliation: Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. nullah@kfupm.edu.sa
authors.forename: Nisar
authors.initials: N
authors.lastname: Ullah
authors.forename: Shamsuddeen A
authors.initials: SA
authors.lastname: Haladu
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; C545427:aspergillusol A; D014443:Tyrosine