title: Platelet glycoprotein IIIa (platelet antigen 1/platelet antigen 2) polymorphism and 1-year outcome in patients with stable coronary artery disease.
abstract: Platelet glycoprotein IIb/IIIa is a membrane receptor which plays a key role in coronary artery disease and thrombotic events. However, there is a considerable controversy regarding the clinical impact of glycoprotein IIIa platelet antigen 1 (PlA1)/platelet antigen 2 (PlA2) polymorphism as a risk factor for myocardial infarction. To evaluate the association between glycoprotein IIIa PlA1/PlA2 polymorphism and 1-year cardiovascular events occurrence in aspirin-treated patients with stable coronary artery disease. We prospectively included 188 postacute coronary syndrome patients (183 men) aged 59 ± 10 years and receiving aspirin (250 mg/day). The clinical outcome at 1 year was the composite end point of nonfatal myocardial infarction, stroke, recurrent unstable angina or cardiac death. Genotyping for PlA1/PlA2 polymorphism was conducted using PCR and restriction fragment length polymorphism analysis. The genotype distribution of glycoprotein IIIa PlA1/PlA2 polymorphism was PlA1/PlA1, 55.3%; PlA1/PlA2, 39.3% and PlA2/PlA2, 4%. Incidence of composite end point in homozygous PlA1/PlA1 carriers was significantly higher than in PlA2/PlA2 and PlA1/PlA2 patients [14.4 vs. 3.6% odds ratio 4.5 (1.2-16.6, 95% confidence interval); P = 0.012]. Multivariate analysis identified three strong predictive factors of cardiac death: age more than 65 years [odds ratio = 6.8, (1.4-34, 95% confidence interval); P = 0.018], ventricular ejection fraction less than 50% [odds ratio = 8.6, (1.7-42.6, 95% confidence interval); P = 0.008] and homozygous PlA1/PlA1 genotype [odds ratio = 8.8, (1.0-78.6, 95% confidence interval); P = 0.014]. Our results demonstrated that glycoprotein IIIa PlA1/PlA1 genotype carriers have a significantly increased risks of acute vascular ischemic events associated with a poor prognosis at 1 year. These postacute coronary syndrome patients might require an optimized secondary antithrombotic prophylaxis strategy.
authors.affiliation: Department of Cardiology A, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
authors.forename: Faouzi
authors.initials: F
authors.lastname: Addad
authors.forename: Ismail
authors.initials: I
authors.lastname: Elalamy
authors.forename: Tahar
authors.initials: T
authors.lastname: Chakroun
authors.forename: Fatma
authors.initials: F
authors.lastname: Abderrazek
authors.forename: Zohra
authors.initials: Z
authors.lastname: Dridi
authors.forename: Sonia
authors.initials: S
authors.lastname: Hamdi
authors.forename: Mohssen
authors.initials: M
authors.lastname: Hassine
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ben-Farhat
authors.forename: Grigoris
authors.initials: G
authors.lastname: Gerotziafas
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hatmi
authors.forename: Habib
authors.initials: H
authors.lastname: Gamra
mesh_terms: D000367:Age Factors; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics*; D023381:Endpoint Determination; D005260:Female; D005838:Genotype; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D016896:Treatment Outcome
chemical_list: D039661:Integrin beta3; D001241:Aspirin