[Hypercoagulability and ischemic stroke in young patients].
BACKGROUND
Hypercoagulable states have been reported as an established risk factor for cerebral venous thrombosis, but they have also been proposed as a predisposing factor for cerebral ischemia of arterial origin, especially among young patients. This may have implications on therapeutic management and secondary prevention. We have studied the frequency of prothrombotic abnormalities in young patients with ischaemic stroke, as other classic risk factors are less common in this group.


METHODS
Observational study with sequential inclusion of patients under 55 with stroke or transient ischaemic attack (TIA) admitted to the Stroke Unit from January 2005 through December 2007. We analysed demographic data, severity and subtype of stroke, risk factors, including the presence of hypercoagulable states, and outcome.


RESULTS
We included 100 patients, of whom 65 were men. The mean age was 42.6 ± 8.9 years, 46% with a hypercoagulable state, and no sex differences. Acquired hyperhomocysteinemia was the most common abnormality (18%), followed by protein C or S deficiency (8%), factor V Leiden mutation (5%) and methyl-tetrahydro-folate-reductase (MTHFR) C677T mutation (5%). Other findings included anticardiolipin antibodies (3%), presence of lupus anticoagulant (2%), thrombocytosis (3%) and G20210A prothrombin gene mutation (3%). No association was found between these states and the presence of other vascular risk factors, or more severe stroke or worse outcomes. There was an increased presence of these abnormalities in patients who were classified as atherothrombotic stroke (p = 0.04).


CONCLUSIONS
The hypercoagulable states are common in young patients with ischaemic stroke, being present in up to 46% of them.
Martínez-Martínez
M
M
Servicio de Neurología, Centro de Ictus, Hospital Universitario La Paz, IdiPaz, Renevas, Universidad Autónoma de Madrid, Madrid, España.
Cazorla-García
R
R
Rodríguez de Antonio
L A
LA
Martínez-Sánchez
P
P
Fuentes
B
B
Diez-Tejedor
E
E
D000328:Adult; D000375:Aging / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D019851:Thrombophilia / Q000150:complications / Q000235:genetics / Q000503:physiopathology*