Molecular pathology of wound healing.
Skin-wound healing is an orchestrated biological phenomena consisting of three sequential phases, inflammation, proliferation, and maturation. Many biological substances are involved in the process of wound repair, and this short and simplified overview of wound healing can be adopted to determine wound vitality or wound age in forensic medicine. With the development of genetically engineered animals, essential molecules for skin-wound healing have been identified. Especially, cytokines, and growth factors are useful candidates and markers for the determination of wound vitality or age. Moreover, bone marrow-derived progenitor cells would give significant information to wound age determination. In this review article, some interesting observations are presented, possibly contributing to the future practice of forensic pathologists.
Kondo
Toshikazu
T
Department of Forensic Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Japan. kondot@wakayama-med.ac.jp
Ishida
Yuko
Y
D000375:Aging / Q000473:pathology; D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000502:physiology; D016207:Cytokines / Q000235:genetics / Q000502:physiology; D049429:Forensic Pathology; D006097:Granulation Tissue / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D018919:Neovascularization, Physiologic; D011506:Proteins / Q000235:genetics / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000293:injuries / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000378:metabolism / Q000473:pathology*
D018925:Chemokines; D016207:Cytokines; D018840:HSP70 Heat-Shock Proteins; D011506:Proteins; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C050087:oxygen-regulated proteins