[The expression of CEACAM-1 and CXCL-14 in infantile hemangioma].
OBJECTIVE
To examine the expression of CEACAM-land CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma.


METHODS
The expression of CEACAM-1 and CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating hemangiomas, involuting hemangiomas, involuted hemangiomas. The mean optical density was measured by image analysis system.


RESULTS
The expression of CEACAM-1 in early stage of proliferating hemangiomas was weak or negative, while it was strong in involuting hemangiomas and positive in the involuted stage. The differences between different stages had a statistically significance (P < 0.05). The expression of CXCL-14 was weak or negative in stage of proliferating hemangiomas, positive in involuting hemangiomas and strong in the involuted stage. The differences between different stages had a statistically significance (P < 0.05).


CONCLUSIONS
CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma.
Xu
Guang-Qi
GQ
Department of Aesthetic Plastic and Burn Surgery Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Lü
Ren-Rong
RR
Huo
Ran
R
Guo
Xuan
X
D015703:Antigens, CD / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D019743:Chemokines, CXC / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male
D015703:Antigens, CD; C069847:CD66 antigens; C118056:CXCL14 protein, human; D015815:Cell Adhesion Molecules; D019743:Chemokines, CXC