title: The Gln27Glu polymorphism in β2-adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis.
abstract: BACKGROUND
  β2-adrenoceptor (β2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population. We evaluated Gln27Glu polymorphism in the β2AR gene in obese Saudi populations to investigate the association of β2AR gene with obesity and other related metabolic parameters.
  
  
  METHODS
  We studied possible association of Gln27Glu in β2AR gene with body mass index (BMI), anthropometric measurements and other metabolic parameters. The β2AR gene polymorphism (Gln27Glu) was identified by sequencing PCR products representing locus of interest. Based on BMI, the subjects were divided into three groups, normal weight, overweight and obese. The genotype and allele frequency were calculated separately for each group.
  
  
  RESULTS
  The allelic frequency of Glu27 did not differ amongst the three groups, though the Glu27 homozygote (Glu/Glu) were more in obese subjects and had higher concentration of triglyceride, leptin and insulin compared to in the Gln27 heterozygotes and Gln/Gln homozygotes.
  
  
  CONCLUSIONS
  In this study we were able to provide evidence on the influence of Gln27Glu genetic variant of β2AR gene on lipid phenotypes, insulin and leptin levels in the Saudi populations.
authors.affiliation: Department of Zoology, Center for Scientific and Medical Female Colleges, King Saud University, Riyadh, Saudi Arabia. mahadaghestani@yahoo.com
authors.forename: Maha H
authors.initials: MH
authors.lastname: Daghestani
authors.forename: Arjumand
authors.initials: A
authors.lastname: Warsy
authors.forename: Mazin H
authors.initials: MH
authors.lastname: Daghestani
authors.forename: Ali N
authors.initials: AN
authors.lastname: Al-odaib
authors.forename: Abdelmoneim
authors.initials: A
authors.lastname: Eldali
authors.forename: Nadia A
authors.initials: NA
authors.lastname: Al-Eisa
authors.forename: Sabah
authors.initials: S
authors.lastname: Al-zhrani
mesh_terms: D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D000886:Anthropometry; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D006946:Hyperinsulinism / Q000235:genetics*; D015228:Hypertriglyceridemia / Q000235:genetics*; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012529:Saudi Arabia; D055815:Young Adult
chemical_list: D020738:Leptin; D008055:Lipids