title: Frequencies of micronuclei (MNi), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) in farmers exposed to pesticides in Çanakkale, Turkey.
abstract: This study aimed to determine the incidence of micronuclei (MNi), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) in peripheral blood lymphocytes due to direct exposure to pesticides among 46 farmers in Çanakkale, Turkey. 48 non-exposed individuals living in the same socioeconomic conditions were chosen as control. In addition, a cytokinesis-block proliferation index (CBPI) was calculated. MNi and NBUDs frequencies were significantly higher among the farmers (p < 0.05). Although the NPB frequency of the farmers was higher than the controls, there was no statistical difference. Multiple linear regression analysis showed that apart from gender, no significant effects of various confounding factors were observed. Regarding CBPI, data obtained for the controls were higher than that of the farmers; however, there was no statistically significant difference.
authors.affiliation: Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of Medical Biology, Terzioglu Campus, 17100, Çanakkale, Turkey. coskunafm@yahoo.com
authors.forename: Mahmut
authors.initials: M
authors.lastname: Coskun
authors.forename: Munevver
authors.initials: M
authors.lastname: Coskun
authors.forename: Akin
authors.initials: A
authors.lastname: Cayir
authors.forename: Ozturk
authors.initials: O
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D000383:Agriculture; D004249:DNA Damage; D005260:Female; D006801:Humans; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D015162:Micronucleus Tests; D008875:Middle Aged; D009153:Mutagens / Q000633:toxicity*; D016273:Occupational Exposure / Q000032:analysis*; D010575:Pesticides / Q000633:toxicity*; D014421:Turkey; D055815:Young Adult
chemical_list: D009153:Mutagens; D010575:Pesticides