[Effects of blokade of the dopaminergic D1/D2 receptors on the single and network neuronal activity in the frontal and visual cortices and behavior of cats].
The results obtained at the levels of single and network neuronal activity in the frontal and visual cortices of cats with different types of behavior revealed features of activity of these structures in normal conditions and after local introductions of antagonists of DI/D2 receptors (SCH23390 and raclopride) into the n. accumbens and frontal cortex. Under the influence of the antagonists, long-latency reactions were characterized by a significant increase in the average frequency of neuronal activity in the frontal cortex, whereas in the visual cortex the average frequency decreased as compared to norm. At the same time, the network activity of the same neurons in the frontal cortex did not change but weakened in the visual cortex, which was expressed in a reduction of the number of neuronal interactions within the visual cortex and between the neurons of the frontal and visual cortices. Normally, during the long-latency conditioned reactions, the average frequency of single neuronal activity and the rate of neuronal interactions in the structures under study were significantly higher as compared to the loss of conditioned reactions. Administration of the dopamine antagonists did not change these features. The results suggest different dopamine modulations of the network activity of the cortical zones under study during the conditioned performance, which is expressed in responsiveness of the cortical projection of a trigger signal (the visual cortex) and visual-frontal networks generated in the course of training.
Kuleshova
E P
EP
Zaleshin
A V
AV
Sidorina
V V
VV
Merzhanova
G Kh
GKh
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology; D002415:Cats; D003214:Conditioning, Classical; D065127:Dopamine D2 Receptor Antagonists; D005260:Female; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009415:Nerve Net / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D020891:Raclopride / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D001552:Benzazepines; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D020891:Raclopride