Clinical significance of runt-related transcription factor 1 polymorphism in prostate cancer.
OBJECTIVE
To investigate the association of RUNX1 rs2253319 with clinicopathological characteristics of prostate cancer (PCa) and disease recurrence after radical prostatectomy (RP).


METHODS
Taking advantage of the systematic stage and grade for each tumor in a cohort of 314 patients with localized PCa receiving RP, we evaluated the associations of RUNX1 rs2253319 with age at diagnosis, preoperative prostate-specific antigen (PSA) level, Gleason score, surgical margin, pathologic stage, status of lymph node metastasis, and PSA recurrence after RP.


RESULTS
The minor allele, T, and the minor homozygote TT genotype of RUNX1 rs2253319 were significantly associated with a 1.49- to 2.76-fold higher risk for advanced pathologic stage and a 3.35- to 9.52-fold higher risk for lymph node metastasis. RUNX1 rs2253319 TT genotype was also associated with poorer PSA-free survival compared with the major homozygote CC genotype in Kaplan-Meier analysis (log-rank test, P= 0.038) and multivariate Cox proportional hazards model adjusting for age and PSA concentration (P= 0.045).


CONCLUSIONS
RUNX1 rs2253319 is associated with adverse clinicopathological features and might be a prognostic factor for the recurrence of PSA in patients with PCa receiving RP.
Huang
Shu-Pin
SP
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, China.
Lan
Yu-Hsuan
YH
Lu
Te-Ling
TL
Pao
Jiunn-Bey
JB
Chang
Ta-Yuan
TY
Lee
Hong-Zin
HZ
Yang
Wen-Hui
WH
Hsieh
Chi-Jeng
CJ
Chen
Lu-Min
LM
Huang
Li-Chia
LC
Ting
Wen-Chien
WC
Bao
Bo-Ying
BY
D000368:Aged; D000483:Alleles; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D004812:Epidemiologic Methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
D050676:Core Binding Factor Alpha 2 Subunit