Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits.
Sixty-two codeine-prescribed breastfeeding mothers from a pharmacogenetic study were interviewed regarding the communication of individual CYP2D6 genotype results and overall research findings. All participants wanted to receive the results of their individual genetic tests; however, individuals placed different values on the usefulness of this information toward future medical decisions. Receiving one's pharmacogenetic test results was not associated with a negative psychosocial impact. Thirty-three percent of the participants wished to withhold these results from their physicians. Participants' expectations seem to dictate the extent of transparency of pharmacogenetic research results.
Madadi
P
P
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada.
Joly
Y
Y
Avard
D
D
Chitayat
D C
DC
Smith
M A
MA
Ross
C J D
CJ
Carleton
B C
BC
Hayden
M R
MR
Koren
G
G
D000328:Adult; D001942:Breast Feeding / Q000009:adverse effects / Q000523:psychology; D003061:Codeine / Q000009:adverse effects* / Q000378:metabolism; D015331:Cohort Studies; D003142:Communication; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods / Q000523:psychology; D006801:Humans; D007231:Infant, Newborn; D057240:Patient Preference / Q000523:psychology; D010465:Perception; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends; D010865:Pilot Projects; D011369:Professional-Patient Relations; D011795:Surveys and Questionnaires
D019389:Cytochrome P-450 CYP2D6; D003061:Codeine