Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis.
OBJECTIVE
To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU).


METHODS
Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI.


RESULTS
Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index.


CONCLUSIONS
Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.
Le Roux
Karine
K
Department of Internal Medicine, Hôtel Dieu, Hospices Civils de Lyon, and University Claude Bernard Lyon 1, Lyon, France.
Kodjikian
Laurent
L
Marignier
Romain
R
Bancel
Julien
J
Broussolle
Christiane
C
Sève
Pascal
P
D000328:Adult; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D043025:Oligoclonal Bands / Q000276:immunology; D012189:Retrospective Studies; D013116:Spinal Cord / Q000276:immunology; D013129:Spinal Puncture; D015867:Uveitis, Intermediate / Q000276:immunology*; D055815:Young Adult
D007136:Immunoglobulins; D043025:Oligoclonal Bands