The possible role of cytokines in chemotherapy-induced cognitive deficits.
roinflammatory cytokines play a significant role in the body's immune response to pathogens, including malignant cells. Proinflammatory cytokines are associated with tumor invasion and progressive disease and are released in response to many antineoplastic agents. Exogenous administration and endogenous production ofcytokines is related to a pattern of behaviors known as sickness behavior that has a significant impact on patients' quality of life. The behavioral patterns associated with sickness behavior include inability to concentrate and impaired learning. Identification of sequelae specific to individual cytokine activity provides novel targets for investigation.
Myers
Jamie S
JS
University of Kansas School of Nursing, Kansas City 66160, USA. jamyers@swbell.net
D000970:Antineoplastic Agents / Q000009:adverse effects*; D003072:Cognition Disorders / Q000139:chemically induced*; D016207:Cytokines / Q000378:metabolism*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D055809:Illness Behavior; D018836:Inflammation Mediators / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology
D000970:Antineoplastic Agents; D016207:Cytokines; D018836:Inflammation Mediators