[Free radical oxidation and the mechanisms of antioxidant defense in normal cells and tumor diseases (a lecture)].
The paper gives update on free radical oxidation and an antioxidant defense system in normal cells and cancers. It describes steps of oxidative stress: the emergence of free radicals, the development of chain reactions, and their inhibition by enzymatic and nonenzymatic reactions. A role of iron is shown in lipid peroxidation. The characteristics of major natural antioxidants and their implication in the regulation of the oxidant-antioxidant system in oncological care are given.
Gorozhanskaia
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D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species