Parathyroid adenoma and chondrosarcoma after treatment of pediatric Hodgkin disease.
Treatment of Hodgkin disease (HD) with chemoradiotherapy in children is associated with increased risk for developing secondary neoplasms. Parathyroid adenoma (PTA) and chondrosarcoma (CS) are quite rare types of secondary neoplasms after HD. We describe a 5-year-old boy with stage IV HD, successfully treated with MOPP (mechlorethamine, vincristine, procarbazine, and prednisone)/ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy followed by 35 Gy mantle radiotherapy who developed primary hyperparathyroidism because of benign PTA at the age of 20 years, and died of CS in thoracic vertebrae at the age of 22 years. Consecutive occurrence of PTA and CS after treatment of pediatric HD, to the best of our knowledge, has not been reported earlier.
Keskin
Ebru Yilmaz
EY
Department of Pediatric Hematology, Gazi University, Medical School, Ankara, Turkey. eykeskin@gazi.edu.tr
Gursel
Turkiz
T
Uluoglu
Omer
O
Albayrak
Meryem
M
Kaya
Zuhre
Z
Coskun
Ugur
U
Kocak
Ulker
U
D000236:Adenoma / Q000175:diagnosis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002675:Child, Preschool; D002813:Chondrosarcoma / Q000175:diagnosis*; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D010282:Parathyroid Neoplasms / Q000175:diagnosis*; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D014747:Vinblastine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D011241:Prednisone