Current development of saliva/oral fluid-based diagnostics.
Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.
Yeh
Chih-Ko
CK
Department of Dental Diagnostic Science, University of Texas Health Science Center at San Antonio, USA.
Christodoulides
Nicolaos J
NJ
Floriano
Pierre N
PN
Miller
Craig S
CS
Ebersole
Jeffrey L
JL
Weigum
Shannon E
SE
McDevitt
John
J
Redding
Spencer W
SW
D015415:Biomarkers / Q000032:analysis; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D056656:Lab-On-A-Chip Devices; D012463:Saliva / Q000737:chemistry* / Q000166:cytology / Q000502:physiology
D015415:Biomarkers