title: Reproducibility of viscoelastic property and intraocular pressure measurements obtained with the Ocular Response Analyzer.
abstract: OBJECTIVE
  To analyse the reproducibility of corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) obtained with the ocular response analyzer (ORA).
  
  
  METHODS
  This is a prospective study, nonmasked, of eight successive examinations with the ORA device in 60 normal eyes. Using 30 eyes (one eye per subject), the reproducibility was assessed by comparing the first series of four examinations to the second four and by calculating the within-subject coefficient of variation. The correlation and difference with the fellow eye were analysed, respectively.
  
  
  RESULTS
  The mean values were 10.7 ± 1.8 mmHg, CRF; 10.6 ± 1.6 mmHg, CH; 15.9 ± 3.9 mmHg, IOPg and 16.2 ± 3.7 mmHg, IOPcc. The reproducibility was significantly different for CRF (5.2 ± 5.9%), CH (7.3 ± 8.6%), IOPg (7.7 ± 6.7%) and IOPcc (10.1 ± 8.0%); p < 0.001. Considering the reproducibility, CRF correlated with CH (rs = 0.55; p < 0.001) and showed to be independent of IOPg and IOPcc. The score spread was best for CRF (2.6 ± 1.5 mmHg; 24.0%) compared to IOPg (4.3 ± 1.5 mmHg; 28.1%) and CH (3.1 ± 1.7 mmHg; 29.9%) and worst for IOPcc (5.5 ± 2.5 mmHg; 34.4%). The lowest difference with the fellow eye was observed for CRF (5.0%; p = 0.09). The correlation with the fellow eye was high, especially for IOPcc and CRF (rs > 0.9; p < 0.001) followed by IOPg and CH (rs > 0.8; p < 0.001).
  
  
  CONCLUSIONS
  The ORA device provides reproducible information on viscoelastic properties of the cornea in normal eyes notably CRF and CH. IOPcc was less reproducible. Four measurements per eye were necessary to reach a 10% precision and six for 5%.
authors.affiliation: Quinze-Vingts National Ophthalmology Hospital, Department of Ophthalmology, Paris, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Kopito
authors.forename: Thomas
authors.initials: T
authors.lastname: Gaujoux
authors.forename: Romain
authors.initials: R
authors.lastname: Montard
authors.forename: Olivier
authors.initials: O
authors.lastname: Touzeau
authors.forename: Cécile
authors.initials: C
authors.lastname: Allouch
authors.forename: Vincent
authors.initials: V
authors.lastname: Borderie
authors.forename: Laurent
authors.initials: L
authors.lastname: Laroche
mesh_terms: D000293:Adolescent; D000328:Adult; D001696:Biomechanical Phenomena / Q000502:physiology; D003315:Cornea / Q000502:physiology*; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D004548:Elasticity / Q000502:physiology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008875:Middle Aged; D025341:Principal Component Analysis; D011446:Prospective Studies; D015203:Reproducibility of Results; D055815:Young Adult