title: Effect of low-level laser irradiation on unresponsive oral lichen planus: early preliminary results in 13 patients.
abstract: OBJECTIVE
  To detail the efficacy of low-level laser therapy (LLLT) for the management of oral lichen planus (OLP) unresponsive to standard therapy.
  
  
  BACKGROUND
  OLP is an inflammatory disease that can be painful, mainly in the atrophic and erosive forms. Numerous drugs have been used with dissimilar results, but most treatments are empiric. However, to date, the most commonly used and useful agents for the treatment of OLP are topical corticosteroids.
  
  
  METHODS
  The investigators studied a prospective cohort of 13 patients affected by OLP, who received biostimulation with a pulsed diode laser (GaAs). Patients were exposed to a 904-nm pulsed infrared laser (4 J/cm(2) energy density per minute; spot size, 0.8 cm). Outcome variables, statistically evaluated, were as follows: the size of lesions, visual analogue score of pain, and stability of the obtained result in the follow-up period.
  
  
  RESULTS
  We detailed significant reduction in lesion size and in reported pain. No reported complications or therapy side effects were observed in any of the patients treated.
  
  
  CONCLUSIONS
  This study suggests that LLLT could be a possible treatment for patients with unresponsive OLP. These results, although not conclusive, are a step forward for enhanced management of this quite common condition; however, it would be interesting to the results would be the same with a greater number of patients or in a different clinical setting.
authors.affiliation: Oral Medicine Unit, Dentistry Section, Department of Biological Sciences and Human Oncology, University of Turin, Turin, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Cafaro
authors.forename: Gianni
authors.initials: G
authors.lastname: Albanese
authors.forename: Paolo G
authors.initials: PG
authors.lastname: Arduino
authors.forename: Carbone
authors.initials: C
authors.lastname: Mario
authors.forename: Gianluca
authors.initials: G
authors.lastname: Massolini
authors.forename: Marco
authors.initials: M
authors.lastname: Mozzati
authors.forename: Roberto
authors.initials: R
authors.lastname: Broccoletti
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D054023:Lasers, Semiconductor; D017676:Lichen Planus, Oral / Q000532:radiotherapy*; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000528:radiation effects; D010147:Pain Measurement; D011446:Prospective Studies; D016896:Treatment Outcome