[Therapy for olfactory disorder associated with URTI along with nasal and accessory nasal diseases].
OBJECTIVE
To observe the effect of intranasal jet nebulizing inhalation with budesonide suspension on 20 patients with olfactory disorder due to upper respiratory tract infections (URTI) or nasal and accessory nasal diseases.


METHODS
We tested the twenty patients with upper respiratory infection, naso sinusitis, allergic rhinitis, olfactory cleft disease induced olfactory loss by medical history, physical examination, olfactory tests and medical imaging. Budesonide suspension doses of 1 mg daily was administered by means of intranasal nebulization for 15 days. Olfactory function was assessed by T&T Olfactometry and olfactory event-related potentials before and after treatment, and only T&T Olfactometry was used after every 5 times for inhalation of budesonide.


RESULTS
Of the patients with olfactory disorder, olfactory function was recovered in 90% after the course of treatment, including cured in 25%, improved in 50%, and slightly improved in 15%. And apparent effect was observed to appeared mostly after nebulizing inhalation for 10 times.


CONCLUSIONS
The above findings suggest that intranasal nebulizing inhalation with budesonide may be an effective therapy in the treatment of URTI-related or nasal and accessory nasal diseases related olfactory disorder. It is worth using the therapy.
Guan
Jing
J
Department of Otolaryngology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Ni
Daofeng
D
Wang
Jian
J
Zhu
Yingying
Y
Xu
Chunxiao
C
Chien
Xingming
X
Liu
Jianfeng
J
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology / Q000628:therapy*; D012141:Respiratory Tract Infections / Q000150:complications / Q000628:therapy; D012220:Rhinitis / Q000150:complications / Q000628:therapy*; D012903:Smell; D055815:Young Adult