Structural genomics of histone tail recognition.
CONCLUSIONS
The structural genomics of histone tail recognition web server is an open access resource that presents within mini articles all publicly available experimental structures of histone tails in complex with human proteins. Each article is composed of interactive 3D slides that dissect the structural mechanism underlying the recognition of specific sequences and histone marks. A concise text html-linked to interactive graphics guides the reader through the main features of the interaction. This resource can be used to analyze and compare binding modes across multiple histone recognition modules, to evaluate the chemical tractability of binding sites involved in epigenetic signaling and design small molecule inhibitors.


BACKGROUND
http://www.thesgc.org/resources/histone_tails/


BACKGROUND
matthieu.schapira@utoronto.ca


BACKGROUND
Supplementary data are available at Bioinformatics online.
Wang
Minghua
M
Structural Genomics Consortium, University of Oxford, Headington, Oxford OX37DQ, UK.
Mok
Man Wai
MW
Harper
Hong
H
Lee
Wen Hwa
WH
Min
Jinrong
J
Knapp
Stefan
S
Oppermann
Udo
U
Marsden
Brian
B
Schapira
Matthieu
M
D001665:Binding Sites; D030562:Databases, Protein; D023281:Genomics / Q000379:methods*; D006657:Histones / Q000737:chemistry*; D011487:Protein Conformation
D006657:Histones