title: [The significance of Toll-like receptors in the development of ischemic lesion].
abstract: A role of immune processes in the development of ischemic lesion is reviewed. Special attention is drawn to key receptors of innate immunity--Toll-like receptors (TLR). Main types of these receptors, their ligands, key mechanisms involved in the TLR signal transduction are characterized. The data of experimental and clinical studies of innate immunity factors in the development of ischemic stroke and myocardial infarction are summarized. The authors discuss the similarity of results, the main causes of which may be the evolutional conservatism of TLR and presence of the common pathological process (artery atherosclerosis) in different vascular beds as a common cause that underlie brain and myocardial ischemia.
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Shurdumova
authors.forename: E V
authors.initials: EV
authors.lastname: Konstantinova
mesh_terms: D050197:Atherosclerosis / Q000276:immunology*; D002545:Brain Ischemia / Q000150:complications / Q000276:immunology*; D006801:Humans; D008024:Ligands; D020521:Stroke / Q000209:etiology / Q000276:immunology*; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D008024:Ligands; D051193:Toll-Like Receptors