title: Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters.
abstract: Recent developments in the management of chronic lymphocytic leukemia (CLL) patients have made necessary the availability of dependable prognostic factors. We have developed a prognostic index derived from the multivariate analysis of 339 stage A patients at diagnosis, exhaustively studied for classical and recent predictive markers. Only 4 biologic parameters were found to be independent predictors of progression-free survival (PFS): serum thymidine kinase (sTK), lymphocytosis, β2-microglobulin, and CD38 expression. Two groups were distinguishable: cases with no or 1 risk factor (among whom 85% did not progress after 7 years), and cases with 2 or more factors showing a median PFS of 20 months. Finally, we propose an easy, fast, cost-effective strategy for a trustworthy prognostication in stage A patients, who currently represent more than 80% of the CLL population, allowing physicians to adapt follow-up individually.
authors.affiliation: Université Paris13, Unité de Formation et de Recherche Santé-Médecine-Biologie Humaine (UFR SMBH), Bobigny, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Letestu
authors.forename: Vincent
authors.initials: V
authors.lastname: Lévy
authors.forename: Virginie
authors.initials: V
authors.lastname: Eclache
authors.forename: Fanny
authors.initials: F
authors.lastname: Baran-Marszak
authors.forename: Dominique
authors.initials: D
authors.lastname: Vaur
authors.forename: Dina
authors.initials: D
authors.lastname: Naguib
authors.forename: Olivier
authors.initials: O
authors.lastname: Schischmanoff
authors.forename: Sandrine
authors.initials: S
authors.lastname: Katsahian
authors.forename: Florence
authors.initials: F
authors.lastname: Nguyen-Khac
authors.forename: Frédéric
authors.initials: F
authors.lastname: Davi
authors.forename: Hélène
authors.initials: H
authors.lastname: Merle-Béral
authors.forename: Xavier
authors.initials: X
authors.lastname: Troussard
authors.forename: Florence
authors.initials: F
authors.lastname: Ajchenbaum-Cymbalista
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis*; D015999:Multivariate Analysis; D011379:Prognosis