Ciliary blood flow and aqueous humor production.
Aqueous humor production is a metabolically active process sustained by the delivery of oxygen and nutrients and removal of metabolic waste by the ciliary circulation. This article describes our investigations into the relationship between ciliary blood flow and aqueous humor production. The results presented indicate that there is a dynamic relationship between ciliary blood flow and aqueous humor production, with production being blood flow independent above a critical level of perfusion, and blood flow dependent below it. The results also show that the plateau portion of the relationship shifts up or down depending on the level of secretory stimulation or inhibition, and that oxygen is one critical factor provided by ciliary blood flow. Also presented is a theoretical model of ocular hydrodynamics incorporating these new findings.
Kiel
J W
JW
Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. kiel@uthscsa.edu
Hollingsworth
M
M
Rao
R
R
Chen
M
M
Reitsamer
H A
HA
D000704:Analysis of Variance; D001082:Aqueous Humor / Q000378:metabolism*; D002924:Ciliary Body / Q000033:anatomy & histology / Q000098:blood supply*; D003198:Computer Simulation; D004728:Endothelium, Corneal / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D057446:Hydrodynamics; D007429:Intraocular Pressure / Q000502:physiology; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology
D010100:Oxygen
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