Multiple sclerosis-associated fatigue.
Fatigue is an extremely prevalent issue for multiple sclerosis (MS) patients. Fatigue can affect quality of life, depression, anxiety, motor function and sleep patterns. There are a number of available rating scales designed to detect and assess fatigue. However, the pathophysiology of fatigue is still not completely understood and the treatment of this symptom remains difficult. A number of clinical trials for fatigue in MS have shown some benefit with different interventions, including medication, physical activity and cognitive-behavioral therapy. Nonetheless, further research and the development of more targeted therapies are needed to improve the management of fatigue.
Krupp
Lauren B
LB
Stony Brook University Medical Center, Department of Neurology, Stony Brook, NY 11794-8121, USA. lkrupp@notes.cc.sunysb.edu
Serafin
Dana J
DJ
Christodoulou
Christopher
C
D005221:Fatigue / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology