title: [Current developments in xenon research. Importance for anesthesia and intensive care medicine].
abstract: The noble gas xenon exerts favorable anesthetic properties along with remarkable hemodynamic stability in healthy patients undergoing elective surgery. It represents the nearly ideal anesthetic and provides safe and well controllable anesthesia although the exact mechanism by which xenon produces anesthesia remains to be elucidated. In addition xenon offers organ protective properties for vital organs including the brain, heart and kidneys which seem to be synergistic when used in combination with therapeutic hypothermia. As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting.
authors.affiliation: Klinik für Anästhesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074 Aachen. abruecken@ukaachen.de
authors.forename: A
authors.initials: A
authors.lastname: Brücken
authors.forename: M
authors.initials: M
authors.lastname: Coburn
authors.forename: S
authors.initials: S
authors.lastname: Rex
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
authors.forename: M
authors.initials: M
authors.lastname: Fries
mesh_terms: D000769:Anesthesia, Inhalation / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002316:Cardiotonic Agents; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003422:Critical Care; D006801:Humans; D007036:Hypothermia, Induced; D007674:Kidney Diseases / Q000517:prevention & control; D018696:Neuroprotective Agents; D014978:Xenon / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D018685:Anesthetics, Inhalation; D002316:Cardiotonic Agents; D018696:Neuroprotective Agents; D014978:Xenon
references.citation: Br J Anaesth. 2010 Mar;104(3):351-8
references.pmid: 20118146
references.citation: Anesthesiology. 2006 Apr;104(4):770-6
references.pmid: 16571973
references.citation: BMC Neurosci. 2004 Dec 08;5:55
references.pmid: 15588278
references.citation: Br J Anaesth. 2007 Jun;98(6):756-62
references.pmid: 17485435
references.citation: J Am Soc Nephrol. 2009 Apr;20(4):713-20
references.pmid: 19144758
references.citation: Ann Neurol. 2005 Aug;58(2):182-93
references.pmid: 16049939
references.citation: Anesthesiology. 2005 May;102(5):929-36
references.pmid: 15851879
references.citation: Mol Pharmacol. 2004 Feb;65(2):443-52
references.pmid: 14742687
references.citation: Anesth Analg. 2008 Jan;106(1):129-34, table of contents
references.pmid: 18165567
references.citation: Br J Anaesth. 2008 May;100(5):605-11
references.pmid: 18344556
references.citation: Anesthesiology. 2010 Mar;112(3):614-22
references.pmid: 20124979
references.citation: Anaesthesia. 2002 Oct;57(10):960-6
references.pmid: 12358954
references.citation: Neuroimage. 2010 Jan 1;49(1):720-30
references.pmid: 19703572
references.citation: Crit Care Resusc. 2005 Sep;7(3):233-7
references.pmid: 16545051
references.citation: Crit Care Med. 2008 Feb;36(2):588-95
references.pmid: 18216607
references.citation: Anesth Analg. 2004 Nov;99(5):1398-1401
references.pmid: 15502037
references.citation: Br J Anaesth. 2007 Feb;98(2):236-40
references.pmid: 17210733
references.citation: Eur J Anaesthesiol. 2010 Jul;27(7):660-5
references.pmid: 20134325
references.citation: Anesthesiology. 2010 Mar;112(3):623-30
references.pmid: 20179498
references.citation: Br J Anaesth. 2008 May;100(5):667-75
references.pmid: 18344553
references.citation: Anesthesiology. 2002 Mar;96(3):699-704
references.pmid: 11873047
references.citation: J Physiol. 1946 Dec 6;105(3):197-204
references.pmid: 16991720
references.citation: Br J Anaesth. 2005 Feb;94(2):198-202
references.pmid: 15531620
references.citation: Anesth Analg. 2007 Nov;105(5):1200-6, table of contents
references.pmid: 17959941
references.citation: Br J Anaesth. 2002 Jul;89(1):112-22
references.pmid: 12173224
references.citation: Br J Anaesth. 2008 Jun;100(6):787-91
references.pmid: 18397921
references.citation: Nat Rev Neurosci. 2008 May;9(5):370-86
references.pmid: 18425091
references.citation: Acta Anaesthesiol Scand. 2005 Apr;49(4):494-501
references.pmid: 15777297
references.citation: Anesthesiology. 2006 Jan;104(1):211; author reply 211-2
references.pmid: 16394725
references.citation: Lancet. 1990 Jun 16;335(8703):1413-5
references.pmid: 1972207
references.citation: Anesthesiology. 2007 Jun;106(6):1128-33
references.pmid: 17525587
references.citation: Resuscitation. 2009 May;80(5):584-90
references.pmid: 19328617
references.citation: Br J Anaesth. 2000 Jan;84(1):43-7
references.pmid: 10740546
references.citation: Anesth Analg. 1997 Oct;85(4):931-6
references.pmid: 9322482
references.citation: Anesth Analg. 2009 Feb;108(2):593-600
references.pmid: 19151294
references.citation: Br J Pharmacol. 2005 Jan;144(1):123-32
references.pmid: 15644876
references.citation: Anesthesiology. 2006 Jul;105(1):187-97
references.pmid: 16810011
references.citation: Anesthesiology. 2007 Nov;107(5):756-67
references.pmid: 18073551
references.citation: Anesthesiology. 2006 Nov;105(5):936-43
references.pmid: 17065887
references.citation: Eur J Anaesthesiol. 2005 Nov;22(11):870-4
references.pmid: 16225724
references.citation: Br J Anaesth. 2007 Jun;98(6):722-7
references.pmid: 17468494
references.citation: Br J Anaesth. 2006 Apr;96(4):427-36
references.pmid: 16500952
references.citation: Science. 1951 May 18;113(2942):580-2
references.pmid: 14834873
references.citation: Can J Anaesth. 2005 Nov;52(9):940-3
references.pmid: 16251559
references.citation: Anesth Analg. 2000 Dec;91(6):1327-32
references.pmid: 11093973
references.citation: Nature. 1998 Nov 26;396(6709):324
references.pmid: 9845069
references.citation: Anesthesiology. 2006 Mar;104(3):458-65
references.pmid: 16508392
references.citation: Anesthesiology. 2003 Oct;99(4):876-81
references.pmid: 14508320
references.citation: Crit Care Med. 2008 Aug;36(8):2420-6
references.pmid: 18664790
references.citation: Anesth Analg. 2000 Nov;91(5):1250-5
references.pmid: 11049917
references.citation: Anesthesiology. 2003 Jan;98(1):6-13
references.pmid: 12502972
references.citation: Acta Anaesthesiol Scand. 2008 Oct;52(9):1194-203
references.pmid: 18823457
references.citation: Anesthesiology. 2007 Nov;107(5):768-75
references.pmid: 18073552
references.citation: Anesthesiology. 2007 Mar;106(3):463-71
references.pmid: 17325504
references.citation: Life Sci. 2003 Mar 14;72(17):1909-18
references.pmid: 12597990
references.citation: Eur J Pharmacol. 2004 Aug 2;496(1-3):71-6
references.pmid: 15288577
references.citation: Stroke. 2006 Feb;37(2):501-6
references.pmid: 16373643