Biochemistry of the anterior, medial, and posterior genioglossus in the aged rat.
Age-related tongue weakness may contribute to swallowing deficits in the elderly. One contributing factor may be an alteration in muscle-fiber-type properties with aging. However, it is not clear how muscle fiber types within the aged tongue may vary from those found in young adults, or how fiber types may vary across the anteroposterior axis of the extrinsic tongue muscles. We examined the myosin heavy chain (MHC) composition of anterior, medial, and posterior sections of the genioglossus muscle (GG) in ten old male Fischer 344/Brown Norway rats and compared findings to previously reported data from young adult male rats. Significant differences (p < 0.01) between young adult and old rats were found in the distribution of MHC isoforms along the anteroposterior axis of the muscle. In the anterior, medial, and posterior regions, there was a significantly smaller proportion of type IIb MHC in the old rat GG muscles, while the proportion of type IIx MHC was significantly greater. In the medial region, the proportion of type I MHC was found to be significantly greater in the old rats. Thus, we found a shift to more slowly contracting muscle fibers in the aged rat tongue.
Schaser
Allison J
AJ
Division of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, K4/723 CSC ZN3, 600 Highland Avenue, Madison, WI 53792, USA. schaser@surgery.wisc.edu
Wang
Hao
H
Volz
Lana M
LM
Connor
Nadine P
NP
D000367:Age Factors; D000818:Animals; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry*; D018995:Myosin Heavy Chains / Q000032:analysis*; D051381:Rats; D011916:Rats, Inbred F344; D014059:Tongue / Q000737:chemistry*
D018995:Myosin Heavy Chains
Am J Physiol. 1997 Feb;272(2 Pt 1):C638-49
9124308
Dysphagia. 1994 Fall;9(4):218-20
7805419
J Appl Physiol (1985). 2003 Oct;95(4):1717-27
12970377
Okajimas Folia Anat Jpn. 1990 Mar;66(6):405-15
2139929
J Muscle Res Cell Motil. 1994 Aug;15(4):413-9
7806635
Histochem Cell Biol. 2001 May;115(5):359-72
11449884
J Muscle Res Cell Motil. 1989 Jun;10(3):197-205
2547831
J Gerontol A Biol Sci Med Sci. 2001 May;56(5):B209-17
11320101
Dysphagia. 2007 Jul;22(3):251-65
17457549
Scand J Med Sci Sports. 2003 Feb;13(1):48-55
12535317
Otolaryngol Clin North Am. 1990 Dec;23(6):1045-56
2074979
Clin Geriatr Med. 1992 Aug;8(3):569-77
1504946
J Commun Disord. 1999 Nov-Dec;32(6):373-95; quiz 395-6
10560713
J Physiol. 1993 Dec;472:595-614
8145163
Dysphagia. 1996 Summer;11(3):180-4
8755461
J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):M634-40
11078092
Otolaryngol Head Neck Surg. 2004 Feb;130(2):217-22
14990919
Dev Disabil Res Rev. 2008;14(2):77-86
18646019
Gastroenterology. 1992 Sep;103(3):823-9
1499933
Aging (Milano). 1996 Apr;8(2):99-105
8737607
Semin Speech Lang. 2006 Nov;27(4):245-59
17117351
Ann Otol Rhinol Laryngol. 2002 Nov;111(11):962-7
12450167
Biochem Biophys Res Commun. 2000 May 27;272(1):303-8
10872844
J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):174-82
4708452
Acta Physiol Scand. 1990 Sep;140(1):41-54
2275404
AJR Am J Roentgenol. 1991 Jun;156(6):1181-4
2028863
J Appl Physiol (1985). 1993 Nov;75(5):2337-40
8307894
Semin Neurol. 1996 Dec;16(4):309-17
9112310
J Appl Physiol (1985). 1994 Aug;77(2):493-501
8002492
S Afr J Commun Disord. 1999;46:55-64
10894004
J Speech Lang Hear Res. 2008 Aug;51(4):828-35
18658054
Am J Physiol. 1994 Jun;266(6 Pt 1):G972-7
8023945
Dysphagia. 2004 Spring;19(2):71-7
15382793
Acta Physiol Scand. 1995 Aug;154(4):469-77
7484173
J Histochem Cytochem. 2005 Apr;53(4):445-54
15805419
Dysphagia. 2007 Jul;22(3):210-4
17458585
Anat Rec. 1999 Dec 1;256(4):412-24
10589027
Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1419-25
12657575
Laryngoscope. 2002 Apr;112(4):589-602
12150508
J Am Geriatr Soc. 2005 Dec;53(12):2090-7
16398892
Med Sci Sports Exerc. 1994 Apr;26(4):432-9
8201898
J Appl Physiol (1985). 1997 Jan;82(1):93-101
9029203