Reversible histone methylation regulates brain gene expression and behavior.
Epigenetic chromatin remodeling, including reversible histone methylation, regulates gene transcription in brain development and synaptic plasticity. Aberrant chromatin modifications due to mutant chromatin enzymes or chemical exposures have been associated with neurological or psychiatric disorders such as mental retardation, schizophrenia, depression, and drug addiction. Some chromatin enzymes, such as histone demethylases JARID1C and UTX, are coded by X-linked genes which are not X-inactivated in females. The higher expression of JARID1C and UTX in females could contribute to sex differences in brain development and behavior.
Xu
Jun
J
Tufts University, Department of Biomedical Sciences, North Grafton, MA 01536, USA. jun.xu@tufts.edu
Andreassi
Megan
M
D001921:Brain / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D005260:Female; D015870:Gene Expression; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism; D008745:Methylation; D009473:Neuronal Plasticity / Q000235:genetics
D006657:Histones
Cell. 2007 Feb 23;128(4):693-705
17320507
Nature. 2007 Apr 19;446(7138):882-7
17392792
Cell. 2007 Jul 13;130(1):77-88
17632057
J Med Genet. 2008 Dec;45(12):787-93
18697827
Biol Psychiatry. 2009 Feb 1;65(3):198-203
18814864
Hum Mol Genet. 1994 Jun;3(6):879-84
7951230
Chem Biol. 2006 Jun;13(6):563-7
16793513
Nature. 2007 Oct 11;449(7163):731-4
17713478
Hum Mol Genet. 2002 Jun 1;11(12):1409-19
12023983
PLoS Genet. 2008 Jan;4(1):e9
18208332
Curr Opin Genet Dev. 2006 Jun;16(3):219-24
16650758
Nature. 1995 Nov 30;378(6556):505-8
7477409
Trends Mol Med. 2008 Aug;14(8):341-50
18635399
Curr Opin Neurobiol. 2005 Oct;15(5):500-6
16150588
Am J Med Genet A. 2008 Feb 15;146A(4):505-11
18203167
Horm Res. 2006;65(1):47-56
16397401
Mol Endocrinol. 1995 Feb;9(2):243-54
7776974
Curr Biol. 2007 May 1;17(9):808-12
17462898
Mol Cell. 2008 Aug 22;31(4):520-530
18722178
Cell. 2006 May 5;125(3):483-95
16603237
Science. 2010 Jan 8;327(5962):213-6
20056891
Cell. 2007 Mar 23;128(6):1063-76
17320161
Hum Mol Genet. 2008 Mar 1;17(5):735-46
18045775
Annu Rev Genomics Hum Genet. 2008;9:109-27
18489256
J Biol Chem. 1999 May 28;274(22):15633-45
10336460
Oncogene. 1993 Nov;8(11):3149-56
8414517
Epigenetics. 2009 Jan;4(1):47-53
19029819
Science. 2007 Oct 19;318(5849):447-50
17761849
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20912-7
19934035
Nat Struct Mol Biol. 2010 Jan;17(1):38-43
20023638
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19176-81
17142323
Biochem Biophys Res Commun. 2008 Feb 8;366(2):563-7
18078810
Nat Cell Biol. 2005 Nov;7(11):1113-7
16227968
Nat Rev Mol Cell Biol. 2009 Oct;10(10):697-708
19738629
Nature. 2003 Jun 19;423(6942):825-37
12815422
Am J Hum Genet. 2005 Feb;76(2):227-36
15586325
Eur J Neurosci. 2005 Jun;21(11):3017-22
15978012
J Neurosci. 2006 Feb 22;26(8):2335-42
16495461
Mol Cell. 2008 Mar 28;29(6):653-63
18374642
Nature. 2007 Oct 11;449(7163):689-94
17851529
Nature. 2007 Nov 8;450(7167):309-13
17994099
Biol Psychiatry. 2007 Jun 15;61(12):1351-60
17161381
Nature. 2007 Aug 2;448(7153):553-60
17603471
J Neurosci. 2010 Mar 10;30(10):3589-99
20219993
Nat Rev Genet. 2005 Jan;6(1):46-57
15630421
Mol Cell. 2010 Apr 23;38(2):165-78
20346720
Nature. 2007 May 31;447(7144):601-5
17468742
J Neurochem. 2005 Jul;94(2):324-36
15998284
Curr Opin Cell Biol. 2008 Jun;20(3):316-25
18440794
Nature. 2007 Dec 13;450(7172):1106-10
18033247
Hum Mol Genet. 1996 Sep;5(9):1361-6
8872478
Nature. 2005 Sep 15;437(7057):436-9
16079795
Gene Expr Patterns. 2006 Jan;6(2):146-55
16325480
Mol Cell. 2005 Sep 16;19(6):857-64
16140033
Nature. 2003 Jan 9;421(6919):177-82
12483227
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8023-8
17463086
Arch Biochem Biophys. 2007 Apr 1;460(1):56-66
17353003
Cell. 2007 Mar 9;128(5):877-87
17320162
Neuron. 2009 Dec 10;64(5):678-91
20005824
Curr Opin Genet Dev. 2008 Apr;18(2):159-68
18281209
Science. 1996 Mar 8;271(5254):1423-7
8596916
Endocrinology. 2005 Aug;146(8):3280-5
15905317
Cell. 2008 Oct 31;135(3):549-60
18984165
Nat Genet. 2009 May;41(5):521-3
19330029
Horm Behav. 2003 Sep;44(3):242-57
14609546
Hum Mutat. 2006 Apr;27(4):389
16541399
Brain. 2003 Nov;126(Pt 11):2431-46
12958079
Nat Rev Neurosci. 2007 May;8(5):355-67
17453016
Chromosome Res. 2009;17(5):637-48
19802704
Eur J Hum Genet. 2006 May;14(5):583-6
16538222
Cytogenet Cell Genet. 1998;80(1-4):37-40
9678332
Horm Behav. 2008 Sep;54(4):565-70
18590732
Clin Genet. 2007 Jul;72(1):19-22
17594395
Curr Opin Genet Dev. 2008 Jun;18(3):273-9
18662779
Am J Med Genet C Semin Med Genet. 2007 Nov 15;145C(4):383-92
17910072
Clin Genet. 2007 Aug;72(2):145-9
17661819
Nature. 1997 Jun 12;387(6634):705-8
9192895
J Neurosci. 2008 Apr 23;28(17):4521-7
18434530
J Med Genet. 2005 Oct;42(10):780-6
16199551
PLoS One. 2008 Jul 02;3(7):e2553
18596936
Nat Cell Biol. 2007 Mar;9(3):347-53
17277772
Hum Mol Genet. 1996 Sep;5(9):1355-60
8872477
Biol Reprod. 2007 Nov;77(5):754-64
17634443
Genes Dev. 2007 Mar 1;21(5):537-51
17311883
Cell. 2007 Feb 9;128(3):505-518
17289570
J Neurosci. 2007 Oct 17;27(42):11254-62
17942719
Front Neuroendocrinol. 2009 Jan;30(1):1-9
19028515
Trends Genet. 2001 Dec;17(12):697-701
11718922
Behav Brain Funct. 2007 May 21;3:24
17517138
Endocrinology. 1997 Nov;138(11):4768-73
9348204
Nat Genet. 2006 Jan;38(1):47-53
16341221
J Neurosci. 2009 Feb 4;29(5):1496-502
19193896
Front Neuroendocrinol. 2005 Sep;26(2):85-102
16083951
Nature. 2007 Nov 1;450(7166):119-23
17943087
Nat Genet. 1998 Mar;18(3):212-3
9500539
Nature. 2001 Jul 26;412(6845):449-52
11473321
Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R27-32
15809269
Nat Struct Mol Biol. 2010 Apr;17(4):445-50
20208542
Cytogenet Genome Res. 2002;99(1-4):36-43
12900543
Cell. 2007 Oct 5;131(1):58-69
17884155
Genes Brain Behav. 2008 Aug;7(6):609-17
18363850
Genes Dev. 2006 Jul 15;20(14):1848-67
16847345
Neuron. 2008 Dec 26;60(6):961-74
19109904
Genome Res. 2010 May;20(5):614-22
20363980
Mol Cell. 2007 Apr 13;26(1):89-101
17434129
Annu Rev Biochem. 2010;79:155-79
20373914
Behav Genet. 2010 Mar;40(2):211-9
20155394
Nat Neurosci. 2006 Apr;9(4):519-25
16501568
Hum Mol Genet. 1998 Apr;7(4):737-42
9499428
Nature. 2010 Apr 29;464(7293):1351-6
20428171
Mol Biol Cell. 2007 Jun;18(6):2356-66
17429066
Hum Mol Genet. 2004 Sep 1;13(17):1849-55
15238507
Mol Cell. 2007 Nov 30;28(4):665-76
18042460
Cell. 2007 Mar 23;128(6):1077-88
17320160
Nat Rev Mol Cell Biol. 2007 Apr;8(4):307-18
17342184
Endocrinology. 2005 Apr;146(4):1650-73
15618360
Nature. 2005 Mar 17;434(7031):400-4
15772666
Eur J Hum Genet. 2005 May;13(5):641-8
15741991
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4465-70
11904358
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5942-6
17389367
Behav Brain Res. 2010 Mar 17;208(1):47-55
19896504
Endocrinology. 2004 Mar;145(3):1046-9
14645115
Nat Genet. 1994 Aug;7(4):491-6
7951318
J Biol Chem. 2006 Jul 28;281(30):21209-21215
16717091
Nat Neurosci. 2004 Oct;7(10):1034-9
15452574
Hum Mol Genet. 1996 Nov;5(11):1695-701
8922996
J Neurosci. 2002 Oct 15;22(20):9005-14
12388607
Dev Cell. 2005 Jan;8(1):31-42
15669143