Current techniques for MR imaging of atherosclerosis.
Vessel wall imaging of large vessels has the potential to identify culprit atherosclerotic plaques that lead to cardiovascular events. Comprehensive assessment of atherosclerotic plaque size, composition, and biological activity is possible with magnetic resonance imaging (MRI). Magnetic resonance imaging of the atherosclerotic plaque has demonstrated high accuracy and measurement reproducibility for plaque size. The accuracy of in vivo multicontrast MRI for identification of plaque composition has been validated against histological findings. Magnetic resonance imaging markers of plaque biological activity such as neovasculature and inflammation have been demonstrated. In contrast to other plaque imaging modalities, MRI can be used to study multiple vascular beds noninvasively over time. In this review, we compare the status of in vivo plaque imaging by MRI to competing imaging modalities. Recent MR technological improvements allow fast, accurate, and reproducible plaque imaging. An overview of current MRI techniques required for carotid plaque imaging including hardware, specialized pulse sequences, and processing algorithms are presented. In addition, the application of these techniques to coronary, aortic, and peripheral vascular beds is reviewed.
Balu
Niranjan
N
Department of Radiology, University of Washington, Seattle, WA, USA.
Wang
Jinnan
J
Dong
Li
L
Baluyot
Florence
F
Chen
Huijun
H
Yuan
Chun
C
D050197:Atherosclerosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001808:Blood Vessels / Q000473:pathology*; D016893:Carotid Stenosis / Q000175:diagnosis; D003324:Coronary Artery Disease / Q000175:diagnosis; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D058729:Peripheral Arterial Disease / Q000175:diagnosis; D058226:Plaque, Atherosclerotic / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional