A look at autoimmunity and inflammation in the eye.
Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.
Caspi
Rachel R
RR
Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892, USA. rcaspi@helix.nih.gov
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D004195:Disease Models, Animal; D005123:Eye / Q000033:anatomy & histology / Q000276:immunology* / Q000473:pathology; D005544:Forecasting; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000276:immunology / Q000473:pathology; D014605:Uveitis / Q000276:immunology / Q000473:pathology
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