title: The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.
abstract: BACKGROUND
  The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors.
  
  
  METHODS
  The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardiovascular events, death, and other important patient-centered outcomes. This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers. Participants will be followed for up to four years, and will undergo serial evaluation during the index hospitalization, at three months post-hospitalization, and at annual clinic visits, with telephone interviews occurring during the intervening six-month intervals. Biospecimens will be collected at each visit, along with information on lifestyle behaviors, quality of life and functional status, cognitive function, receipt of therapies, interim renal and cardiovascular events, electrocardiography and urinalysis.
  
  
  CONCLUSIONS
  ASSESS-AKI will characterize the short-term and long-term natural history of AKI, evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI, and identify a subset of high-risk patients who could be targeted for future clinical trials to improve outcomes after AKI.
authors.affiliation: Kaiser Permanente Northern California, Oakland, CA, USA. alan.s.go@kp.org
authors.forename: Alan S
authors.initials: AS
authors.lastname: Go
authors.forename: Chirag R
authors.initials: CR
authors.lastname: Parikh
authors.forename: T Alp
authors.initials: TA
authors.lastname: Ikizler
authors.forename: Steven
authors.initials: S
authors.lastname: Coca
authors.forename: Edward D
authors.initials: ED
authors.lastname: Siew
authors.forename: Vernon M
authors.initials: VM
authors.lastname: Chinchilli
authors.forename: Chi-Yuan
authors.initials: CY
authors.lastname: Hsu
authors.forename: Amit X
authors.initials: AX
authors.lastname: Garg
authors.forename: Michael
authors.initials: M
authors.lastname: Zappitelli
authors.forename: Kathleen D
authors.initials: KD
authors.lastname: Liu
authors.forename: W Brian
authors.initials: WB
authors.lastname: Reeves
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Ghahramani
authors.forename: Prasad
authors.initials: P
authors.lastname: Devarajan
authors.forename: Georgia Brown
authors.initials: GB
authors.lastname: Faulkner
authors.forename: Thida C
authors.initials: TC
authors.lastname: Tan
authors.forename: Paul L
authors.initials: PL
authors.lastname: Kimmel
authors.forename: Paul
authors.initials: P
authors.lastname: Eggers
authors.forename: John B
authors.initials: JB
authors.lastname: Stokes
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003625:Data Collection / Q000379:methods; D003627:Data Interpretation, Statistical; D018450:Disease Progression; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic; D008875:Middle Aged; D018579:Patient Selection; D011379:Prognosis; D011446:Prospective Studies; D012107:Research Design; D013995:Time; D055815:Young Adult
chemical_list: D015415:Biomarkers
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