title: Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder.
abstract: Previous studies suggest that deficits in neural synchronization and temporal integration are characteristic of schizophrenia. These phenomena have been rarely studied in SPD, which shares phenomenological and genetic similarities with schizophrenia. Event-related potentials (ERPs) were obtained using an auditory oddball task from 21 patients with schizophrenia, 19 subjects with SPD and 19 healthy control subjects. Inter-trial coherence (ITC) and event-related spectral perturbation (ERSP) were measured across trials to target tones using time-frequency analysis. ITC measures phase locking or consistency, while ERSP measures changes in power relative to baseline activity. P300 latency and amplitude were also measured from the averaged ERP to target tones. In the time-frequency analysis, subjects with SPD showed intact power but a deficit in the ITC in delta and theta frequencies compared to control subjects. Patients with schizophrenia showed deficits for both ERSP and ITC in the delta and theta frequencies. While patients with schizophrenia showed reduced P300 amplitude and delayed latency for averaged ERPs, subjects with SPD did not differ from either group. Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration.
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, United States.
authors.forename: Yong-Wook
authors.initials: YW
authors.lastname: Shin
authors.forename: Giri
authors.initials: G
authors.lastname: Krishnan
authors.forename: William P
authors.initials: WP
authors.lastname: Hetrick
authors.forename: Colleen A
authors.initials: CA
authors.lastname: Brenner
authors.forename: Anantha
authors.initials: A
authors.lastname: Shekhar
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Malloy
authors.forename: Brian F
authors.initials: BF
authors.lastname: O'Donnell
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D016022:Case-Control Studies; D003700:Delta Rhythm; D004569:Electroencephalography; D058407:Electroencephalography Phase Synchronization; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000503:physiopathology* / Q000523:psychology; D013826:Theta Rhythm
references.citation: Neurosci Lett. 2008 Aug 8;440(3):304-8
references.pmid: 18571323
references.citation: Science. 2002 Jan 25;295(5555):690-4
references.pmid: 11809976
references.citation: Psychiatry Res. 1995 Apr 28;56(3):229-36
references.pmid: 7568545
references.citation: Nature. 2003 Oct 23;425(6960):828-32
references.pmid: 14574410
references.citation: Schizophr Res. 1993 Dec;11(1):81-92
references.pmid: 8297808
references.citation: Biol Psychol. 2009 Mar;80(3):292-9
references.pmid: 19028546
references.citation: Neuroimage. 2009 Oct 1;47(4):1711-9
references.pmid: 19371786
references.citation: Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):468-84
references.pmid: 6187540
references.citation: Biol Psychiatry. 2008 Sep 1;64(5):392-400
references.pmid: 18436196
references.citation: Arch Gen Psychiatry. 1993 Oct;50(10):781-8
references.pmid: 8215802
references.citation: Biol Psychiatry. 1996 Aug 1;40(3):165-72
references.pmid: 8830949
references.citation: Trends Neurosci. 2009 Jan;32(1):9-18
references.pmid: 19012975
references.citation: Arch Gen Psychiatry. 1999 Nov;56(11):1001-5
references.pmid: 10565499
references.citation: Electroencephalogr Clin Neurophysiol. 1980 Sep;49(5-6):497-505
references.pmid: 6158431
references.citation: Clin Neurophysiol. 2000 May;111(5):837-49
references.pmid: 10802455
references.citation: Hum Brain Mapp. 2001 Nov;14(3):166-85
references.pmid: 11559961
references.citation: J Neurosci. 2007 Apr 4;27(14):3839-44
references.pmid: 17409248
references.citation: Psychiatry Clin Neurosci. 2001 Oct;55(5):451-7
references.pmid: 11555339
references.citation: Biol Psychol. 2003 Jan;62(1):65-87
references.pmid: 12505768
references.citation: Neuroreport. 2000 Apr 7;11(5):1097-103
references.pmid: 10790889
references.citation: Biol Psychiatry. 2000 Oct 1;48(7):702-5
references.pmid: 11032982
references.citation: Biol Psychiatry. 1994 Jan 15;35(2):96-103
references.pmid: 8167215
references.citation: Schizophr Bull. 1987;13(2):261-76
references.pmid: 3616518
references.citation: Psychophysiology. 2003 Sep;40(5):684-701
references.pmid: 14696723
references.citation: Arch Gen Psychiatry. 2000 Jan;57(1):57-64
references.pmid: 10632233
references.citation: Schizophr Bull. 2007 Jan;33(1):69-94
references.pmid: 17135482
references.citation: Schizophr Bull. 1991;17(4):555-64
references.pmid: 1805349
references.citation: Neuropsychobiology. 1997;35(2):108-14
references.pmid: 9097303
references.citation: Neuron. 2006 Oct 5;52(1):155-68
references.pmid: 17015233
references.citation: Biol Psychiatry. 2008 Apr 15;63(8):744-7
references.pmid: 18083143
references.citation: Neuron. 2005 Jan 6;45(1):147-56
references.pmid: 15629709
references.citation: Neuroscience. 2007 Jun 8;146(4):1435-44
references.pmid: 17459593
references.citation: Brain Cogn. 2005 Jun;58(1):94-108
references.pmid: 15878730
references.citation: Brain Res. 2008 Oct 15;1235:133-42
references.pmid: 18621027
references.citation: Brain Cogn. 2008 Jul;67(2):150-61
references.pmid: 18262701
references.citation: Int J Psychophysiol. 2009 Jan;71(1):75-83
references.pmid: 18725254
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14843-8
references.pmid: 17785415
references.citation: Biol Psychiatry. 1999 Jul 1;46(1):94-101
references.pmid: 10394478
references.citation: Schizophr Res. 1998 Aug 17;32(3):183-90
references.pmid: 9720123
references.citation: Biol Psychol. 2002 Oct;61(1-2):111-38
references.pmid: 12385672
references.citation: Schizophr Bull. 2008 Sep;34(5):927-43
references.pmid: 18562344
references.citation: Biol Psychol. 1995 Oct;41(2):103-46
references.pmid: 8534788
references.citation: J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):33-40
references.pmid: 8845699
references.citation: Psychophysiology. 2009 May;46(3):566-77
references.pmid: 19298628
references.citation: J Neurosci Methods. 2004 Mar 15;134(1):9-21
references.pmid: 15102499