Mitochondria and viruses.
Mitochondria are involved in a variety of cellular metabolic processes, and their functions are regulated by extrinsic and intrinsic stimuli including viruses. Recent studies have shown that mitochondria play a central role in the primary host defense mechanisms against viral infections, and a number of novel viral and mitochondrial proteins are involved in these processes. Some viral proteins localize in mitochondria and interact with mitochondrial proteins to regulate cellular responses. This review summarizes recent findings on the functions and roles of these molecules as well as mitochondrial responses to viral infections.
Ohta
Akane
A
Department of Virology, Graduate School of Medicine, Nagoya University, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
Nishiyama
Yukihiro
Y
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008928:Mitochondria / Q000276:immunology* / Q000821:virology*; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000276:immunology*
Protein Sci. 2007 Apr;16(4):695-703
17384234
J Virol. 1998 Sep;72(9):7583-8
9696857
Mol Cell. 2005 Feb 4;17(3):393-403
15694340
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9411-6
15192152
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8653-8
19433799
Nature. 2008 Dec 4;456(7222):605-10
19052620
J Virol. 2002 Apr;76(8):3936-42
11907233
J Virol. 2009 Apr;83(8):3420-8
19193783
Biochem Pharmacol. 2002 Nov 15;64(10):1425-30
12417255
J Virol. 2002 Jan;76(2):802-16
11752170
J Biol Chem. 2003 Dec 26;278(52):52437-45
14563855
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8744-9
9238048
J Virol. 2007 Oct;81(20):11054-68
17686858
J Virol. 1997 Apr;71(4):3039-47
9060664
Arch Virol. 2005 Aug;150(8):1579-90
15789261
J Virol. 2007 Oct;81(19):10486-95
17652400
J Gen Virol. 2001 Apr;82(Pt 4):871-882
11257193
Immunity. 2008 May;28(5):651-61
18439848
J Virol. 2006 Apr;80(8):3752-64
16571792
Immunol Rev. 2009 Jan;227(1):189-202
19120485
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14345-50
14610284
Virus Res. 2002 Jun;86(1-2):87-92
12076832
J Virol. 2002 Sep;76(17):8939-52
12163613
Genes Dev. 2007 Apr 15;21(8):929-41
17403773
Virology. 1996 Jan 15;215(2):152-64
8560762
Science. 2001 Apr 27;292(5517):727-30
11326099
Physiol Rev. 2007 Jan;87(1):99-163
17237344
Immunity. 2008 Oct 17;29(4):538-50
18818105
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5
17709747
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9035-40
17517627
Can J Biochem Cell Biol. 1985 Nov;63(11):1194-7
4084857
J Exp Med. 2004 Mar 1;199(5):629-40
14993250
EMBO J. 2002 Dec 16;21(24):6801-10
12486001
Nature. 2008 Jan 31;451(7178):573-7
18200010
Cell. 1996 Jul 12;86(1):147-57
8689682
Mol Cell. 2005 Sep 16;19(6):727-40
16153868
Sci Signal. 2009 Aug 18;2(84):ra47
19690333
J Virol. 2007 Oct;81(20):11426-40
17670831
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10410-5
11517326
Annu Rev Immunol. 2001;19:475-96
11244044
J Virol. 2001 Mar;75(6):2535-43
11222676
Oncogene. 2008 Jan 17;27(4):421-33
17653091
Cell Death Differ. 2005 Aug;12 Suppl 1:905-15
15761473
J Virol. 2000 Mar;74(5):2151-60
10666244
J Exp Med. 2001 Oct 15;194(8):1097-110
11602639
J Virol. 2007 Jan;81(2):514-24
17079289
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):582-7
17190814
Virus Res. 2009 Nov;145(2):307-11
19682511
J Virol. 2002 Nov;76(22):11491-504
12388711
Adv Exp Med Biol. 1996;406:83-97
8910674
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6
19926846
J Virol. 1997 Jul;71(7):5579-92
9188632
J Virol. 1998 Nov;72(11):8772-81
9765421
Cell Death Differ. 2008 Oct;15(10):1564-71
18551131
Mitochondrion. 2002 Feb;1(4):349-59
16120289
J Biol Chem. 2002 Mar 15;277(11):9219-25
11741880
Cell. 2005 Sep 9;122(5):669-82
16125763
Virology. 2004 Feb 20;319(2):212-24
14980482
Mol Immunol. 2008 Apr;45(8):2277-87
18207245
Virology. 1996 Nov 1;225(1):227-30
8918551
Nature. 1999 Jun 3;399(6735):483-7
10365962
Int Rev Immunol. 2003 Sep-Dec;22(5-6):451-76
12959754
Cell. 2000 Jul 7;102(1):33-42
10929711
Nature. 1988 Sep 29;335(6189):440-2
3262202
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5663-8
19293378
J Immunol. 2005 Dec 15;175(12):8226-35
16339562
J Gen Virol. 1988 Jun;69 ( Pt 6):1405-10
2838578
J Biol Chem. 2004 Nov 26;279(48):50295-301
15371414
J Virol. 2002 Mar;76(5):2469-79
11836425
J Immunol. 2005 Sep 1;175(5):2851-8
16116171
Genes Dev. 1996 Feb 15;10(4):461-77
8600029
Oncogene. 2001 Nov 26;20(54):7836-46
11753666
J Neurovirol. 2005 Apr;11(2):190-8
16036797
J Virol. 1991 Jun;65(6):2968-78
1851867
J Gen Virol. 2007 Jun;88(Pt 6):1656-1666
17485524
Int J Cancer. 2002 Feb 20;97(6):732-9
11857347
Mitochondrion. 2009 Feb;9(1):1-8
18992370
J Mol Biol. 2003 Oct 3;332(5):1123-30
14499614
Curr Biol. 2002 May 14;12(10):838-43
12015121
Cell Death Differ. 2005 Nov;12 Suppl 2:1478-80
16247494
Cancer Gene Ther. 2007 Jun;14(6):533-42
17415379
Virology. 2002 Aug 15;300(1):39-49
12202204
J Biol Chem. 2010 Feb 19;285(8):5569-80
20022954
EMBO Rep. 2010 Feb;11(2):133-8
20019757
Mol Cell. 2001 Sep;8(3):613-21
11583623
EMBO J. 2006 Jul 26;25(14):3257-63
16858409
Cytokine. 2008 Sep;43(3):350-8
18703349
Science. 2007 Jun 1;316(5829):1345-8
17540903
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7253-8
17438296
J Mol Cell Cardiol. 2009 Jun;46(6):821-31
19265700
Virol J. 2009 Dec 01;6:213
19951438
J Gen Virol. 2006 Aug;87(Pt 8):2155-2159
16847111
J Biol Chem. 2003 May 16;278(20):18256-64
12595532
Nature. 1991 May 23;351(6324):317-20
2034275
J Virol. 2004 May;78(9):4599-608
15078942
J Biol Chem. 2004 Jul 16;279(29):30081-91
15138279
J Clin Invest. 2003 May;111(10):1547-54
12750404
Oncogene. 1998 Sep 10;17(10):1195-205
9771962
J Virol. 1998 Jun;72(6):4686-93
9573232
PLoS Biol. 2005 Dec;3(12):e404
16277553
Exp Cell Res. 2004 Oct 1;299(2):486-97
15350546
Cell. 1992 May 15;69(4):597-604
1339309
J Gen Virol. 1999 Oct;80 ( Pt 10):2737-2740
10573168
Immunol Rev. 2009 Jan;227(1):75-86
19120477
Cancer Res. 1994 May 15;54(10):2808-11
8168114
J Biol Chem. 2002 Dec 20;277(51):49360-5
12381734
Mitochondrion. 2009 Jun;9(3):222-6
19269351
J Virol. 1998 Oct;72(10):8392-5
9733891
Nature. 1999 Feb 4;397(6718):441-6
9989411
Biochem Biophys Res Commun. 2004 May 28;318(2):461-9
15120623
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17264-9
15563593
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8479-83
8397406
Cell. 2002 Nov 1;111(3):331-42
12419244
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6629-34
15100416
J Biol Chem. 2010 Feb 12;285(7):4695-708
19955184
Virology. 2004 Jan 5;318(1):169-82
14972545
EMBO Rep. 2007 Feb;8(2):188-93
17186027
Cell. 1990 Dec 21;63(6):1129-36
2175676
Proc Natl Acad Sci U S A. 2004 May 25;101(21):7988-93
15148411
Oncogene. 2008 Jan 10;27(3):285-99
17700538
Neurosci Lett. 2003 Nov 20;351(3):201-5
14623140
Microbes Infect. 2002 Jun;4(7):707-12
12067830
Mol Cell Biol. 2004 May;24(9):3938-48
15082787
Nature. 2009 Oct 8;461(7265):788-92
19776740
Nat Immunol. 2005 Oct;6(10):981-8
16127453
PLoS Pathog. 2008 May 30;4(5):e1000018
18516228
J Virol. 2003 Jan;77(1):631-41
12477866
Exp Neurol. 1998 Dec;154(2):276-88
9878167
Nature. 2001 Jul 5;412(6842):95-9
11452314
Oncogene. 1999 Dec 9;18(52):7543-51
10602513
J Exp Med. 2002 Nov 4;196(9):1127-39
12417624
Nat Immunol. 2004 Jul;5(7):730-7
15208624
J Virol. 2004 Jun;78(12):6420-30
15163735
Cell Death Differ. 2009 Nov;16(11):1419-25
19696789
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7829-34
11427719
J Virol. 2004 Jul;78(13):7097-111
15194786
J Virol. 2007 Jun;81(12):6459-70
17428859
J Virol. 2008 Jul;82(13):6172-89
18417577
Biochimie. 2002 Feb-Mar;84(2-3):203-14
12022951
J Virol. 2007 Jun;81(12):6346-55
17428862
Virology. 2008 Jun 5;375(2):561-72
18329683
J Neurosci. 2006 Apr 12;26(15):4054-62
16611822
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2770-5
19196953
Biochem Cell Biol. 1986 Dec;64(12):1303-9
2436639
J Exp Med. 2004 Apr 5;199(7):993-1003
15067035
Virology. 2004 Nov 10;329(1):53-67
15476874
Biochem Biophys Res Commun. 2002 Sep 27;297(3):682-7
12270148
Biochimie. 2002 Feb-Mar;84(2-3):177-85
12022948
J Virol. 2000 Nov;74(21):10104-11
11024139
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17717-22
16301520
J Virol. 2007 Dec;81(24):13315-24
17913820
PLoS One. 2009;4(5):e5466
19404494
Virus Res. 2005 Apr;109(1):65-9
15826914
J Gen Virol. 2000 Feb;81(Pt 2):401-6
10644838
Retrovirology. 2008 Jul 09;5:62
18613978
Genes Cells. 2000 Dec;5(12):1017-27
11168588
Oncogene. 1999 Nov 25;18(50):6965-73
10597295
Arch Virol. 1993;133(3-4):259-73
8257288
J Virol. 1992 Aug;66(8):4720-31
1629952
J Cell Biochem. 1997 Aug 1;66(2):245-55
9213225
Cell Death Differ. 2002 Nov;9(11):1172-84
12404116
Virology. 1994 Jun;201(2):404-7
8184552
J Virol. 2006 Dec;80(24):12332-42
17020950
EMBO J. 2006 Sep 20;25(18):4207-14
16946700
J Virol. 2003 Jul;77(13):7214-24
12805420
J Virol. 2004 Jun;78(12):6304-12
15163724
J Virol. 2006 Apr;80(7):3341-8
16537601
Trends Cell Biol. 2009 Sep;19(9):455-64
19716304
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):637-42
11805321
Nature. 2006 May 4;441(7089):101-5
16625202
Microbiol Immunol. 2003;47(1):91-9
12636258
PLoS Pathog. 2007 Dec;3(12):e174
18069888
J Virol. 2005 Apr;79(7):4170-9
15767418
Microbes Infect. 1999 Jul;1(8):601-7
10611736
Nature. 2008 Oct 2;455(7213):674-8
18724357
Rev Med Virol. 2004 Jan-Feb;14(1):33-46
14716690
J Cell Biochem. 2000 May;78(2):334-49
10842327
Science. 2006 Nov 10;314(5801):994-7
17038590
Mol Cell Biol. 2008 Aug;28(16):5014-26
18559423
J Virol. 2009 Feb;83(3):1299-311
19036819
J Virol. 2007 Jan;81(2):964-76
17093192
Virus Genes. 2002 Jun;24(3):257-66
12086147
Cell. 1998 Aug 21;94(4):491-501
9727492
J Virol. 2009 Mar;83(6):2601-10
19129438
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):690-4
9012846
Science. 1995 Apr 21;268(5209):429-31
7716549
Nature. 1991 Aug 29;352(6338):824-7
1715519
Cell. 2009 Aug 7;138(3):576-91
19631370
Virol J. 2008 Oct 22;5:125
18940012
PLoS Pathog. 2005 Sep;1(1):e10
16201011
J Exp Med. 2000 Jan 3;191(1):33-46
10620603
J Gen Virol. 2006 Jul;87(Pt 7):1935-1945
16760395
EMBO J. 2002 Jun 3;21(11):2602-15
12032073
J Virol. 2010 Mar;84(5):2421-31
20032188
J Virol. 1999 Jun;73(6):5181-5
10233985
Nature. 2005 Oct 20;437(7062):1167-72
16177806
Cell Death Differ. 2010 Apr;17(4):655-65
19816509