title: Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders.
abstract: Neurodegenerative disorders (ND) belong to the most devastating diseases in the industrialized western world. Alzheimer disease (AD) is the most prevalent among these disorders followed by Parkinson disease (PD). Huntington disease (HD) is an autosomal dominantly inherited condition with a single mutation that causes disease in almost 100% of all cases. In this review we used previously published proteomics studies on AD, PD and HD to find cellular pathways changed similarly in ND and aging. All studies employed large gel two dimensional gel electrophoresis for protein separation and mass spectrometry for protein identification. Altered proteins were subjected to a KEGG pathway analysis and altered pathways determined for each disorder and aging. We found that besides the mitochondrial oxidative phosphorylation, the proteasome system are altered in aging and ND. The proteasome facilitates protein degradation which is commonly perturbed in ND which may link neurodegeneration to its largest risk factor-aging.
authors.affiliation: Institute for Human Genetics, Charité, University Medicine Berlin, Berlin, Germany. claus.zabel@charite.de
authors.forename: Claus
authors.initials: C
authors.lastname: Zabel
authors.forename: Huu Phuc
authors.initials: HP
authors.lastname: Nguyen
authors.forename: Sascha C
authors.initials: SC
authors.lastname: Hin
authors.forename: Daniela
authors.initials: D
authors.lastname: Hartl
authors.forename: Lei
authors.initials: L
authors.lastname: Mao
authors.forename: Joachim
authors.initials: J
authors.lastname: Klose
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D019636:Neurodegenerative Diseases / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D010085:Oxidative Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D012307:Risk Factors
chemical_list: D046988:Proteasome Endopeptidase Complex