Three-dimensional structures of DNA-bound transcriptional regulators.
Our understanding of the detailed mechanisms of specific promoter/enhancer DNA-binding site recognition by transcriptional regulatory factors is primarily based on three-dimensional structural studies using the methods of X-ray crystallography and NMR. Vast amount of accumulated experimental data have revealed the basic principles of protein-DNA complex formation paving the way for better modeling and prediction of DNA-binding properties of transcription factors. In this review, our intent is to provide a general overview of the three-dimensional structures of DNA-bound transcriptional regulators starting from the basic principles of specific DNA recognition and ending with high-order multiprotein-DNA complexes.
Shrivastava
Tripti
T
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. tshrivastava@unmc.edu
Tahirov
Tahir H
TH
D020816:Amino Acid Motifs; D000818:Animals; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
D014157:Transcription Factors; D004247:DNA