Ameliorative effect of sesame lignans on nicotine toxicity in rats.
Nicotine causes oxidative and genotoxic damages in the tissues leading to several diseases. Any strategy through natural diet that prevents or slows the progression and severity of nicotine toxicity has a significant health impact. This work is designed to investigate natural antioxidants that play effective protective role against nicotine-induced toxicity. Experiments were conducted on male albino rats by injecting nicotine tartrate (3.5 mg/kg body wt./day for 15 days) subcutaneously and thereby supplementing sesame lignans (0.1 g/100g diet and 0.2 g/100g diet) orally to them. Significant (P<0.01) increase of total cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol, decrease of HDL-cholesterol, decrease in antioxidant enzymes and increase in concentration of lipid peroxidative product has been observed in plasma due to nicotine toxicity. Significant (P<0.01) decrease of total DNA contents and highly significant (P<0.001) DNA damage of liver tissue is also observed on nicotine treatment. Sesame lignans minimizes the above mentioned effects. The nicotine-induced oxidative and genotoxic damages on the tissues can be effectively attenuated by sesame lignans supplemented diet.
Chattopadhyay
Krishna
K
Department of Chemical Technology, University of Calcutta, Kolkata, India. kris_ami@yahoo.co.in
Mondal
Srinath
S
Chattopadhyay
Brajadulal
B
Ghosh
Santinath
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D020552:Comet Assay; D004247:DNA / Q000032:analysis; D004249:DNA Damage; D004336:Drug Antagonism; D017705:Lignans / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009153:Mutagens / Q000633:toxicity*; D009538:Nicotine / Q000633:toxicity*; D018722:Nicotinic Agonists / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D031685:Sesamum / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D017705:Lignans; D008055:Lipids; D009153:Mutagens; D018722:Nicotinic Agonists; D010936:Plant Extracts; D008315:Malondialdehyde; D009538:Nicotine; D004247:DNA; D002374:Catalase; D013482:Superoxide Dismutase