Enantioselective 1,6-conjugate addition to cyclic dienones catalyzed by the Cu-DiPPAM complex.
In the presence of a Cu/DiPPAM catalytic system, various diorganozinc reagents realize 1,6-asymmetric conjugate addition on various cyclic five- and six-membered cyclic dienones, with complete regioselectivity and high ee's (93-99%).
Wencel-Delord
Joanna
J
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France.
Alexakis
Alexandre
A
Crévisy
Christophe
C
Mauduit
Marc
M