title: Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia.
abstract: OBJECTIVE
  The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia.
  
  
  METHODS
  A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine.
  
  
  RESULTS
  Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls.
  
  
  CONCLUSIONS
  In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yonsei University Health System, Seoul, Korea.
authors.forename: Ga Hyun
authors.initials: GH
authors.lastname: Son
authors.forename: Jeong Hyeon
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung Hae
authors.initials: JH
authors.lastname: Hwang
authors.forename: Young Han
authors.initials: YH
authors.lastname: Kim
authors.forename: Yong Won
authors.initials: YW
authors.lastname: Park
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Kwon
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000652:urine*; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012720:Severity of Illness Index
chemical_list: D008565:Membrane Proteins; C113267:nephrin