Evidence of the involvement of K+ channels and PPARgamma receptors in the antidepressant-like activity of diphenyl diselenide in mice.
OBJECTIVE
This study investigated the involvement of different types of K(+) channels and PPARgamma receptors in the antidepressant-like effect of diphenyl diselenide in mice.


METHODS
Mice were pretreated with subeffective doses of K(+) channel inhibitors (tetraethylammonium, glibenclamide, charybdotoxin and apamin), openers (cromakalim, minoxidil), GW 9662 (a PPARgamma antagonist) or vehicle. Thirty minutes later the mice received diphenyl diselenide in either an effective or a subeffective dose, 30 min before a tail-suspension test.


RESULTS
Pre-treatment with tetraethylammonium, charybdotoxin or apamin combined with a subeffective dose of diphenyl diselenide was effective in decreasing the immobility time in the mouse tail-suspension test. The reduction in the immobility time elicited by an effective dose of diphenyl diselenide in this test was prevented by the pretreatment of mice with minoxidil and GW 9662.


CONCLUSIONS
Diphenyl diselenide elicited an antidepressant-like effect and this action was mediated, at least in part, by modulation of K(+) channels and PPARgamma receptors.
Wilhelm
Ethel A
EA
Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Brazil.
Jesse
Cristiano R
CR
Bortolatto
Cristiani F
CF
Barbosa
Nilda B V
NB
Nogueira
Cristina W
CW
D000813:Anilides / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D001555:Benzene Derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D019806:Cromakalim / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy*; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008914:Minoxidil / Q000494:pharmacology; D016566:Organoselenium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D047495:PPAR gamma / Q000037:antagonists & inhibitors*; D026902:Potassium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D015221:Potassium Channels / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
C457499:2-chloro-5-nitrobenzanilide; D000813:Anilides; D000928:Antidepressive Agents; D001555:Benzene Derivatives; D016566:Organoselenium Compounds; D047495:PPAR gamma; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D014665:Vasodilator Agents; D019806:Cromakalim; C061132:diphenyldiselenide; D008914:Minoxidil