title: Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T.
abstract: Arterial spin labeling (ASL) is a promising non-invasive magnetic resonance imaging (MRI) technique for measuring regional cerebral blood flow (rCBF) or perfusion in vivo. To evaluate the feasibility of ASL as a biomarker for clinical trials, it is important to examine test-retest reproducibility. We investigated both inter- and intra-session reproducibility of perfusion MRI using a pulsed ASL (PASL) sequence PICORE Q2TIPS with an echo-planar imaging (EPI) readout. Structural MRI regions of interest (ROIs) were extracted individually by automated parcellation and segmentation methods using FreeSurfer. These cortical and subcortical ROIs were used to assess regional perfusion stability. Our results indicated regional variability in grey matter rCBF. Although rCBF measurements were characterized by intersubject variation, our results also indicated relatively less within-subject variability estimated as within-subject standard deviation (SD(W)) (intersession SD(W): 2.0 to 8.8; intrasession SD(W): 2.8 to 9.6) and acceptable reliabilities as measured using intraclass correlation coefficient (ICC) (intersession ICC: 0.68 to 0.94; intrasession ICC: 0.66 to 0.95) for regional MRI perfusion measurements using the PICORE Q2TIPS technique. Overall, our findings suggest that PASL is a technique with good within and between session reproducibility. Further reproducibility studies in target populations relevant for specific clinical trials of neurovascular related agents will be important and the present results provide a framework for such assessments.
authors.affiliation: IU Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA. ywang1@iupui.edu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Saykin
authors.forename: Josef
authors.initials: J
authors.lastname: Pfeuffer
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Mosier
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Sungeun
authors.initials: S
authors.lastname: Kim
authors.forename: Gary D
authors.initials: GD
authors.lastname: Hutchins
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D015203:Reproducibility of Results; D013113:Spin Labels
chemical_list: D013113:Spin Labels
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