title: Ultrasonographic findings in Cairn Terriers with preclinical renal dysplasia.
abstract: Renal dysplasia is a hereditary disease characterized by abnormal differentiation of renal tissue. The ultrasonographic appearance of dysplastic canine kidneys has been reported in the late stage of the disease where inflammatory and degenerative changes are already present and the dogs are in chronic renal failure. In this study, we describe the ultrasonographic appearance of the kidneys of five related Cairn Terriers affected with renal dysplasia before the onset of clinical or laboratory evidence of renal failure. Common findings included poor corticomedullary definition and multifocal hyperechoic speckles in the renal medulla, or a diffusely hyperechoic medulla. Severity of ultrasonographic changes was related to the severity of histopathologic findings. The ability to detect dysplastic changes before clinical signs develop makes ultrasound a potentially useful screening method for canine renal dysplasia.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA 19104-6010, USA. gsseiler@ncsu.edu
authors.forename: Gabriela S
authors.initials: GS
authors.lastname: Seiler
authors.forename: James
authors.initials: J
authors.lastname: Rhodes
authors.forename: Rachel
authors.initials: R
authors.lastname: Cianciolo
authors.forename: Margret L
authors.initials: ML
authors.lastname: Casal
mesh_terms: D000375:Aging; D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D005260:Female; D007839:Functional Laterality; D052177:Kidney Diseases, Cystic / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008297:Male; D007690:Polycystic Kidney Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D014463:Ultrasonography / Q000379:methods / Q000662:veterinary*
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