title: Customization of normal data base specific for 3-tesla MRI is mandatory in VSRAD analysis.
abstract: A voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) was used for quantitative analysis of parahippocampal atropy with 1.5-tesla (T) MRI in a voxel-wise manner. The analysis of images acquired under a different imaging condition provides an error factor that has a calculated value. Clinical application of 3T-MRI is necessary for establishing a normal data base (N-DB) specific for 3T-MRI data, which permits appropriate application of VSRAD. We established an N-DB specific for 3T-MRI for use in VSRAD. The "Z-score of the parahippocampal gyrus" was 0.79 +/- 0.32, and the N-DB of each age group did not have a big deflection when we analyzed a group of physically unimpaired persons in an N-DB specific for 3T-MRI. Therefore, we were able to confirm the validity of the customized N-DB. The "Z-score of the parahippocampal gyrus" was 1.62 +/- 0.47 for the N-DB of VSRAD. The numerical value was high for the group of physically unimpaired persons.
authors.affiliation: Department of Radiological Technology, University of Tokyo Hospital, Tokyo, Japan. car6_pa2_rw@yahoo.co.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Goto
authors.forename: Yuuichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Naoto
authors.initials: N
authors.lastname: Hayashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Masumoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yoshirou
authors.initials: Y
authors.lastname: Satake
authors.forename: Kenji
authors.initials: K
authors.lastname: Ino
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yano
authors.forename: Kyouhito
authors.initials: K
authors.lastname: Iida
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mima
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D000367:Age Factors; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D002490:Central Nervous System / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000502:physiology; D016208:Databases, Factual; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020534:Parahippocampal Gyrus / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D011859:Radiography
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