title: Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To explore the serum anti-mullerian hormone (AMH) level in adolescent and young adult Chinese patients with polycystic ovary syndrome (PCOS), and to evaluate its diagnostic value for PCOS.
  
  
  METHODS
  Serum AMH was measured in a cohort of 47 adolescent and young adult Chinese patients with PCOS and 40 age-matched controls. Its diagnostic potential was evaluated by Receiver Operating Characteristic (ROC) curves.
  
  
  RESULTS
  The serum AMH level was higher in PCOS patients than in controls (9.85 ± 4.93 ng/mL vs. 7.13 ± 3.02 ng/mL, P = 0.002), and positively related to the mean ovarian volume in PCOS patients (r = 0.319, P = 0.029). The area under the ROC curve for AMH reached a value of 0.664 (0.551-0.778, 95% confidence interval). The best compromise between specificity (70%) and sensitivity (61.7%) was obtained with a cut-off value of 8 ng/mL.
  
  
  CONCLUSIONS
  Serum AMH levels are elevated in adolescent and young adult Chinese patients of PCOS. Serum AMH measurement offers a relatively poor diagnostic potency with a sensitivity of 61.7% and a specificity of 70% at 8 ng/mL.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Mo
authors.forename: Yaxiao
authors.initials: Y
authors.lastname: Chen
authors.forename: Meiying
authors.initials: M
authors.lastname: Wenig
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
references.citation: Mol Cell Endocrinol. 2008 Jan 30;282(1-2):95-100
references.pmid: 18191888
references.citation: Clin Endocrinol (Oxf). 2005 Sep;63(3):267-73
references.pmid: 16117813
references.citation: Am J Obstet Gynecol. 2007 Jan;196(1):77.e1-5
references.pmid: 17240243
references.citation: Reproduction. 2002 Nov;124(5):601-9
references.pmid: 12416998
references.citation: Mol Hum Reprod. 2004 Feb;10(2):77-83
references.pmid: 14742691
references.citation: Exp Biol Med (Maywood). 2004 May;229(5):369-77
references.pmid: 15096648
references.citation: Endocrinology. 1995 Nov;136(11):4951-62
references.pmid: 7588229
references.citation: Ultrasound Obstet Gynecol. 2008 Oct;32(5):700-3
references.pmid: 18773451
references.citation: J Clin Endocrinol Metab. 2004 Jan;89(1):318-23
references.pmid: 14715867
references.citation: Int J Gynaecol Obstet. 2007 May;97(2):129-34
references.pmid: 17368460
references.citation: Hum Reprod Update. 2005 Mar-Apr;11(2):143-60
references.pmid: 15705960
references.citation: Zhonghua Fu Chan Ke Za Zhi. 2007 Sep;42(9):590-4
references.pmid: 17983512
references.citation: J Reprod Fertil. 1987 Jul;80(2):509-16
references.pmid: 3309279
references.citation: Trends Endocrinol Metab. 2008 Nov;19(9):340-7
references.pmid: 18805020
references.citation: J Clin Endocrinol Metab. 2003 Dec;88(12):5957-62
references.pmid: 14671196
references.citation: Development. 1991 Oct;113(2):613-24
references.pmid: 1782869
references.citation: Hum Reprod. 2004 Jan;19(1):41-7
references.pmid: 14688154
references.citation: Cell. 1986 Jun 6;45(5):685-98
references.pmid: 3754790
references.citation: Eur J Obstet Gynecol Reprod Biol. 2008 Jul;139(1):59-64
references.pmid: 18378061
references.citation: Reproduction. 2006 Jan;131(1):1-9
references.pmid: 16388003
references.citation: J Clin Endocrinol Metab. 2006 Mar;91(3):941-5
references.pmid: 16368745
references.citation: Fertil Steril. 2002 Feb;77(2):357-62
references.pmid: 11821097
references.citation: Hum Reprod. 2006 Aug;21(8):2027-32
references.pmid: 16684838
references.citation: Neuro Endocrinol Lett. 2007 Dec;28(6):807-10
references.pmid: 18063948