Hydrophilic polymer matrices in optical array sensing.
Whether in a glass chip or multi-well plate, differential array sensors are performed as a series of experiments and their output is compared among each other to obtain the differential signals evaluated by pattern recognition methods. To increase the practicality of performing a large number of experiments the sensor elements are often used as semi-wet gels displaying properties of both the solution and the solid state. Due to their semi-wet nature, such array sensors are easier to handle while offering a mechanical support, the affinity of hydrophilic matrices for water aids in analyte transport, and the tunable hydrophilic/hydrophobic nature of the matrices can be used adjusting the preference of the chemosensor membrane for different analytes.
Anzenbacher
Pavel
P
Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA. pavel@bgsu.edu
Liu
Yuan-Li
YL
Kozelkova
Maria E
ME
D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D046208:Microchip Analytical Procedures; D011108:Polymers / Q000737:chemistry*
D020100:Hydrogels; D011108:Polymers