title: Drainage of esophageal leakage using endoscopic vacuum therapy: a prospective pilot study.
abstract: OBJECTIVE
  Major leakage from an esophageal anastomosis is a life-threatening surgical complication. Endoscopically guided endoluminal vacuum therapy using polyurethane sponges is a new method for treating such leakage.
  
  
  METHODS
  Between June 2007 and June 2009, five patients (mean age 68 years) who developed anastomotic leakage after esophageal surgery were prospectively evaluated. After endoscopic diagnosis of a major leakage, polyurethane sponges were endoscopically positioned in the wound cavity of the anastomosis. Continuous suction was applied via drainage tubes fixed to the sponges. Initially sponges were endoscopically changed three times per week.
  
  
  RESULTS
  In all five patients treatment was successful. Median time to reduce levels of inflammation markers by 50 % was 10 days for white blood cell (WBC) count and 7 days for C-reactive protein (CRP). The smallest initial wound cavity size was 42 cm (3) and the largest was 157 cm (3). The median duration of drainage was 28 days, with a median of 9 sponge changes and a median time to total cavity closure of 42 days. Two patients needed anastomotic dilation by Savary-Miller bougienage due to stenosis found on further follow-up. One of these patients died of acute severe hemorrhage from an aortoanastomotic fistula after the dilation procedure.
  
  
  CONCLUSIONS
  Endoscopically assisted vacuum therapy is a well-tolerated and effective therapeutic option for treatment of major esophageal leaks after surgery. Additional surgery was avoided in all cases. However, the occurrence of a delayed aortoesophageal fistula calls for careful further investigation of this new technique.
authors.affiliation: Department of General Surgery and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Ahrens
authors.forename: T
authors.initials: T
authors.lastname: Schulte
authors.forename: J
authors.initials: J
authors.lastname: Egberts
authors.forename: C
authors.initials: C
authors.lastname: Schafmayer
authors.forename: J
authors.initials: J
authors.lastname: Hampe
authors.forename: A
authors.initials: A
authors.lastname: Fritscher-Ravens
authors.forename: D C
authors.initials: DC
authors.lastname: Broering
authors.forename: B
authors.initials: B
authors.lastname: Schniewind
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D004322:Drainage / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D016629:Esophagectomy / Q000009:adverse effects*; D004947:Esophagus / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011183:Postoperative Complications / Q000601:surgery*; D011446:Prospective Studies; D013396:Suction / Q000379:methods; D015503:Surgical Sponges; D016896:Treatment Outcome; D014618:Vacuum