Association of a Notch 3 gene polymorphism with migraine susceptibility.
BACKGROUND
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4, respectively, of the Notch 3 gene in migraine.


RESULTS
The first part of the study, in a population of 275 migraineurs and 275 control individuals, found a significant association between the C381T variant and migraine, specifically in migraine without aura (MO) sufferers. The G684A variant was also found to be significantly associated with migraine, specifically in migraine with aura (MA) sufferers. A follow-up study in 300 migraineurs and 300 control individuals did not show replicated association of the C381T variant with migraineurs. However, the G684A variant was again shown to be significantly associated with migraine, specifically with MA.


CONCLUSIONS
Further investigation of the G684A variant and the Notch 3 gene is warranted to understand their role in migraine.
Menon
S
S
Genomics Research Centre, Griffith Institute of Healthand Medical Research, Griffith University, Gold Coast, Queensland, Australia 4215.
Cox
H C
HC
Kuwahata
M
M
Quinlan
S
S
MacMillan
J C
JC
Haupt
L M
LM
Lea
R A
RA
Griffiths
L R
LR
D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D000071656:Receptor, Notch3; D051880:Receptors, Notch / Q000235:genetics*
C499374:NOTCH3 protein, human; D000071656:Receptor, Notch3; D051880:Receptors, Notch