title: COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  No drug has been proven efficacious to prevent the post-pericardiotomy syndrome (PPS), but colchicine seems safe and effective for the treatment and prevention of pericarditis. The aim of the COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS) trial is to test the efficacy and safety of colchicine for the primary prevention of the PPS.
  
  
  RESULTS
  The COPPS study is a multicentre, double-blind, randomized trial. On the third post-operative day, 360 patients (mean age 65.7 ± 12.3 years, 66% males), 180 in each treatment arm, were randomized to receive placebo or colchicine (1.0 mg twice daily for the first day followed by a maintenance dose of 0.5 mg twice daily for 1 month in patients ≥70 kg, and halved doses for patients <70 kg or intolerant to the highest dose). The primary efficacy endpoint was the incidence of PPS at 12 months. Secondary endpoint was the combined rate of disease-related hospitalization, cardiac tamponade, constrictive pericarditis, and relapses. Baseline characteristics were well balanced between the study groups. Colchicine significantly reduced the incidence of the PPS at 12 months compared with placebo (respectively, 8.9 vs. 21.1%; P = 0.002; number needed to treat = 8). Colchicine also reduced the secondary endpoint (respectively, 0.6 vs. 5.0%; P = 0.024). The rate of side effects (mainly related to gastrointestinal intolerance) was similar in the colchicine and placebo groups (respectively, 8.9 vs. 5.0%; P = 0.212).
  
  
  CONCLUSIONS
  Colchicine is safe and efficacious in the prevention of the PPS and its related complications and may halve the risk of developing the syndrome following cardiac surgery. ClinicalTrials.gov number, NCT00128427.
authors.affiliation: Department of Cardiology, Maria Vittoria Hospital, Via Cibrario 72, 10141 Torino, Italy. massimo_imazio@yahoo.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Imazio
authors.forename: Rita
authors.initials: R
authors.lastname: Trinchero
authors.forename: Antonio
authors.initials: A
authors.lastname: Brucato
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Rovere
authors.forename: Anna
authors.initials: A
authors.lastname: Gandino
authors.forename: Roberto
authors.initials: R
authors.lastname: Cemin
authors.forename: Stefania
authors.initials: S
authors.lastname: Ferrua
authors.forename: Silvia
authors.initials: S
authors.lastname: Maestroni
authors.forename: Edoardo
authors.initials: E
authors.lastname: Zingarelli
authors.forename: Alberto
authors.initials: A
authors.lastname: Barosi
authors.forename: Caterina
authors.initials: C
authors.lastname: Simon
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Sansone
authors.forename: Davide
authors.initials: D
authors.lastname: Patrini
authors.forename: Ettore
authors.initials: E
authors.lastname: Vitali
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferrazzi
authors.forename: David H
authors.initials: DH
authors.lastname: Spodick
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Adler
mesh_terms: D000368:Aged; D002305:Cardiac Tamponade / Q000209:etiology; D003078:Colchicine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000209:etiology; D011185:Postpericardiotomy Syndrome / Q000517:prevention & control*; D012008:Recurrence; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D050257:Tubulin Modulators; D003078:Colchicine