title: Visuomotor cerebellum in human and nonhuman primates.
abstract: In this paper, we will review the anatomical components of the visuomotor cerebellum in human and, where possible, in non-human primates and discuss their function in relation to those of extracerebellar visuomotor regions with which they are connected. The floccular lobe, the dorsal paraflocculus, the oculomotor vermis, the uvula-nodulus, and the ansiform lobule are more or less independent components of the visuomotor cerebellum that are involved in different corticocerebellar and/or brain stem olivocerebellar loops. The floccular lobe and the oculomotor vermis share different mossy fiber inputs from the brain stem; the dorsal paraflocculus and the ansiform lobule receive corticopontine mossy fibers from postrolandic visual areas and the frontal eye fields, respectively. Of the visuomotor functions of the cerebellum, the vestibulo-ocular reflex is controlled by the floccular lobe; saccadic eye movements are controlled by the oculomotor vermis and ansiform lobule, while control of smooth pursuit involves all these cerebellar visuomotor regions. Functional imaging studies in humans further emphasize cerebellar involvement in visual reflexive eye movements and are discussed.
authors.affiliation: Department of Neuroscience, Erasmus MC, Rotterdam, the Netherlands. janvoogd@bart.nl
authors.forename: Jan
authors.initials: J
authors.lastname: Voogd
authors.forename: Caroline K L
authors.initials: CK
authors.lastname: Schraa-Tam
authors.forename: Jos N
authors.initials: JN
authors.lastname: van der Geest
authors.forename: Chris I
authors.initials: CI
authors.lastname: De Zeeuw
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000033:anatomy & histology* / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology; D006801:Humans; D009068:Movement / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology; D011323:Primates / Q000033:anatomy & histology / Q000502:physiology*; D011698:Pursuit, Smooth / Q000502:physiology; D012018:Reflex / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012438:Saccades / Q000502:physiology; D014785:Vision, Ocular / Q000502:physiology*
references.citation: J Comp Neurol. 1988 Feb 1;268(1):13-28
references.pmid: 3346381
references.citation: Exp Brain Res. 1980;38(1):29-36
references.pmid: 6766109
references.citation: Prog Brain Res. 2006;151:231-68
references.pmid: 16221591
references.citation: J Comp Neurol. 1993 Apr 1;330(1):130-46
references.pmid: 8468400
references.citation: Exp Brain Res. 2006 Sep;174(2):312-23
references.pmid: 16636788
references.citation: Exp Brain Res. 2009 Jan;192(2):175-87
references.pmid: 18797855
references.citation: J Neurophysiol. 2003 Aug;90(2):1011-26
references.pmid: 12904501
references.citation: Exp Brain Res. 2000 May;132(2):243-59
references.pmid: 10853949
references.citation: Annu Rev Neurosci. 2001;24:981-1004
references.pmid: 11520925
references.citation: Ann N Y Acad Sci. 1996 Jun 19;781:553-79
references.pmid: 8694444
references.citation: J Comp Neurol. 1990 Dec 8;302(2):330-48
references.pmid: 1705268
references.citation: Brain Res. 1974 Nov 22;80(3):512-6
references.pmid: 4547632
references.citation: J Comp Neurol. 1985 May 1;235(1):1-25
references.pmid: 3989000
references.citation: J Comp Neurol. 1995 May 22;356(1):23-50
references.pmid: 7543121
references.citation: J Comp Neurol. 1988 May 22;271(4):473-92
references.pmid: 2454970
references.citation: J Neurosci. 2010 Mar 10;30(10):3715-27
references.pmid: 20220005
references.citation: J Comp Neurol. 1989 Dec 8;290(2):262-77
references.pmid: 2480371
references.citation: Prog Brain Res. 2008;171:177-86
references.pmid: 18718298
references.citation: J Comp Neurol. 1990 Nov 22;301(4):618-42
references.pmid: 2273101
references.citation: J Comp Neurol. 1993 Jan 1;327(1):63-82
references.pmid: 7679420
references.citation: Vis Neurosci. 1993 Jan-Feb;10(1):59-72
references.pmid: 8424928
references.citation: Neuron. 2007 Jun 21;54(6):973-85
references.pmid: 17582336
references.citation: Cereb Cortex. 2005 Jul;15(7):913-20
references.pmid: 15459083
references.citation: J Neurophysiol. 2000 Sep;84(3):1289-302
references.pmid: 10980003
references.citation: J Neurophysiol. 1994 Aug;72(2):974-98
references.pmid: 7983549
references.citation: Brain Res. 1994 Feb 28;638(1-2):12-20
references.pmid: 7515317
references.citation: Brain Res Bull. 2003 Jun 15;60(5-6):511-41
references.pmid: 12787870
references.citation: J Neurophysiol. 2010 Jan;103(1):519-30
references.pmid: 19923249
references.citation: Ann N Y Acad Sci. 1992 May 22;656:775-82
references.pmid: 1599183
references.citation: Brain Res. 1967 Mar;4(2):151-88
references.pmid: 4961812
references.citation: J Comp Neurol. 2002 Mar 5;444(2):144-58
references.pmid: 11835187
references.citation: Prog Brain Res. 2008;171:167-72
references.pmid: 18718296
references.citation: Science. 1988 Nov 4;242(4879):771-3
references.pmid: 3142040
references.citation: Prog Brain Res. 1979;50:431-42
references.pmid: 317846
references.citation: J Comp Neurol. 1992 Mar 15;317(3):250-70
references.pmid: 1577999
references.citation: J Comp Neurol. 2010 May 15;518(10):1764-91
references.pmid: 20235174
references.citation: J Comp Neurol. 1992 Jan 1;315(1):98-116
references.pmid: 1371782
references.citation: Eur J Neurosci. 1998 Jul;10(7):2328-36
references.pmid: 9749761
references.citation: J Neurophysiol. 1998 Oct;80(4):1911-31
references.pmid: 9772249
references.citation: J Comp Neurol. 1986 Dec 15;254(3):410-24
references.pmid: 3491843
references.citation: J Comp Neurol. 1985 May 1;235(1):26-37
references.pmid: 3989003
references.citation: J Comp Neurol. 1995 May 22;356(1):1-22
references.pmid: 7629304
references.citation: Physiol Rev. 1987 Jul;67(3):797-857
references.pmid: 3299410
references.citation: Brain Cogn. 2008 Dec;68(3):229-40
references.pmid: 18835077
references.citation: J Comp Neurol. 1977 Aug 15;174(4):607-30
references.pmid: 903421
references.citation: Vision Res. 2004 Dec;44(28):3419-27
references.pmid: 15536010
references.citation: J Neurophysiol. 1995 Feb;73(2):632-50
references.pmid: 7760123
references.citation: Arch Ital Biol. 1967 Nov;105(4):441-79
references.pmid: 5585723
references.citation: J Comp Neurol. 1985 May 15;235(3):343-59
references.pmid: 3998215
references.citation: Exp Brain Res. 2005 Aug;165(2):203-16
references.pmid: 15864563
references.citation: J Neurosci. 2003 Aug 27;23(21):7904-16
references.pmid: 12944521
references.citation: J Neurophysiol. 1993 Jan;69(1):57-73
references.pmid: 8433134
references.citation: Exp Brain Res. 2002 Nov;147(2):252-63
references.pmid: 12410340
references.citation: Exp Brain Res. 1992;88(2):455-8
references.pmid: 1577117
references.citation: Neurosci Res. 1988 Jun;5(5):424-38
references.pmid: 3399147
references.citation: J Neurophysiol. 2008 Jan;99(1):220-30
references.pmid: 17977929
references.citation: J Comp Neurol. 2000 Oct 16;426(2):209-28
references.pmid: 10982464
references.citation: J Neurophysiol. 2007 Feb;97(2):1114-26
references.pmid: 17093114
references.citation: Cerebellum. 2009 Sep;8(3):403-15
references.pmid: 19472026
references.citation: J Neurophysiol. 2003 Apr;89(4):2146-58
references.pmid: 12686582
references.citation: Prog Brain Res. 2006;151:1-42
references.pmid: 16221584
references.citation: Annu Rev Neurosci. 1995;18:409-41
references.pmid: 7605068
references.citation: Ophthalmologica. 2002 Nov-Dec;216(6):399-405
references.pmid: 12566881
references.citation: J Neurophysiol. 2002 Jun;87(6):2700-14
references.pmid: 12037172
references.citation: J Comp Neurol. 1989 Nov 1;289(1):53-73
references.pmid: 2478597
references.citation: Exp Brain Res. 1979 Jan 2;34(1):91-105
references.pmid: 83242
references.citation: Hum Brain Mapp. 2004 Jun;22(2):155-64
references.pmid: 15108303
references.citation: J Neurophysiol. 2005 Jan;93(1):108-16
references.pmid: 15317840
references.citation: Neurosci Res. 2008 Mar;60(3):250-8
references.pmid: 18164087
references.citation: Prog Brain Res. 2006;151:461-501
references.pmid: 16221598
references.citation: J Neurophysiol. 1990 Jan;63(1):37-59
references.pmid: 2299385
references.citation: Brain Res. 2007 Mar 2;1135(1):107-21
references.pmid: 17210146
references.citation: J Comp Neurol. 1989 Feb 1;280(1):1-14
references.pmid: 2465325
references.citation: J Neurosci. 2008 Jan 30;28(5):1140-52
references.pmid: 18234892
references.citation: Prog Brain Res. 2006;151:407-40
references.pmid: 16221596
references.citation: J Neurophysiol. 1986 Oct;56(4):1129-46
references.pmid: 3783233
references.citation: J Comp Neurol. 2001 Apr 23;433(1):48-61
references.pmid: 11283948
references.citation: Brain Res. 1989 Jul 17;492(1-2):176-86
references.pmid: 2752296
references.citation: J Neurophysiol. 1994 Jul;72(1):31-46
references.pmid: 7965015
references.citation: Cerebellum. 2003;2(2):101-9
references.pmid: 12880177
references.citation: Neurosci Lett. 2009 Oct 2;462(1):10-3
references.pmid: 19559754
references.citation: Vis Neurosci. 2001 Sep-Oct;18(5):725-40
references.pmid: 11925008
references.citation: Acta Astronaut. 1992 Jul;27:25-30
references.pmid: 11537592
references.citation: J Comp Neurol. 1979 Jan 1;183(1):33-45
references.pmid: 102667
references.citation: Neurosci Lett. 2002 Apr 12;322(3):173-6
references.pmid: 11897166
references.citation: J Neurophysiol. 1987 Aug;58(2):359-78
references.pmid: 3655873
references.citation: J Neurosci. 2004 Oct 6;24(40):8771-85
references.pmid: 15470143
references.citation: J Comp Neurol. 1990 Mar 8;293(2):299-330
references.pmid: 19189718
references.citation: J Neurophysiol. 1985 Nov;54(5):1326-45
references.pmid: 4078618
references.citation: J Comp Neurol. 1987 Nov 8;265(2):224-41
references.pmid: 3320110
references.citation: Neuroscience. 2006 Dec 1;143(2):615-26
references.pmid: 16973298
references.citation: Neuroscience. 2008 Sep 22;156(1):216-21
references.pmid: 18706489
references.citation: J Neuroimaging. 2008 Apr;18(2):158-67
references.pmid: 18318793
references.citation: Ann N Y Acad Sci. 1996 Jun 19;781:489-98
references.pmid: 8694438
references.citation: Exp Brain Res. 1986;62(1):29-45
references.pmid: 3956636
references.citation: Arch Ital Biol. 1990 Jul;128(2-4):273-93
references.pmid: 1702611
references.citation: J Comp Neurol. 1975 Apr 1;160(3):363-97
references.pmid: 1112929
references.citation: J Neurophysiol. 2000 Dec;84(6):2945-60
references.pmid: 11110823
references.citation: Hum Brain Mapp. 2006 Apr;27(4):296-305
references.pmid: 16080162
references.citation: Science. 1984 Jul 6;225(4657):74-6
references.pmid: 6610214
references.citation: Prog Brain Res. 1997;114:299-320
references.pmid: 9193151
references.citation: J Neurophysiol. 1996 Jan;75(1):454-68
references.pmid: 8822570
references.citation: Brain Res. 1994 Aug 8;653(1-2):345-50
references.pmid: 7526963
references.citation: Brain Res. 1985 Dec 16;359(1-2):281-91
references.pmid: 4075149
references.citation: J Comp Neurol. 1986 Nov 22;253(4):415-39
references.pmid: 3793998
references.citation: J Comp Neurol. 1987 Apr 1;258(1):52-69
references.pmid: 3571536
references.citation: J Neurophysiol. 2004 Jun;91(6):2484-500
references.pmid: 14749311
references.citation: Exp Brain Res. 2005 May;162(4):526-31
references.pmid: 15864569
references.citation: Exp Brain Res. 1993;93(1):157-64
references.pmid: 8467885
references.citation: J Comp Neurol. 2003 Nov 10;466(2):278-98
references.pmid: 14528453
references.citation: Neurology. 2000 Jan 11;54(1):148-55
references.pmid: 10636141
references.citation: J Neurophysiol. 1988 Aug;60(2):664-86
references.pmid: 3171646
references.citation: J Comp Neurol. 1985 May 1;235(1):38-47
references.pmid: 3989004
references.citation: J Neurosci. 2003 Oct 29;23(30):9742-51
references.pmid: 14586001
references.citation: J Comp Neurol. 1993 Nov 1;337(1):94-112
references.pmid: 8276995
references.citation: Prog Brain Res. 2006;151:205-30
references.pmid: 16221590
references.citation: J Neurophysiol. 2002 Feb;87(2):802-18
references.pmid: 11826048
references.citation: Ann N Y Acad Sci. 1981;374:20-30
references.pmid: 6978631
references.citation: Hum Brain Mapp. 2002 Jun;16(2):63-70
references.pmid: 11954056
references.citation: J Neurophysiol. 2009 Oct;102(4):2039-54
references.pmid: 19625543
references.citation: J Comp Neurol. 1994 Nov 1;349(1):51-72
references.pmid: 7852626
references.citation: J Comp Neurol. 1988 Nov 22;277(4):608-20
references.pmid: 3209748
references.citation: Brain Res. 1989 Nov 13;502(1):75-87
references.pmid: 2479453
references.citation: J Neurosci. 2003 Jun 1;23(11):4645-56
references.pmid: 12805304
references.citation: Brain Res. 1978 Jun 9;148(1):31-42
references.pmid: 77706
references.citation: J Comp Neurol. 1994 Nov 15;349(3):448-63
references.pmid: 7852635
references.citation: J Comp Neurol. 2003 Nov 3;466(1):31-47
references.pmid: 14515239
references.citation: Exp Brain Res. 2008 Mar;185(4):535-44
references.pmid: 17962925
references.citation: Vision Res. 1972 Feb;12(2):183-93
references.pmid: 5033683
references.citation: J Neurosci. 2007 Sep 5;27(36):9696-710
references.pmid: 17804630
references.citation: J Neurosci. 1999 Dec 15;19(24):10931-9
references.pmid: 10594074
references.citation: J Neurosci. 2010 Jun 16;30(24):8111-26
references.pmid: 20554862
references.citation: J Neurophysiol. 2009 Feb;101(2):934-47
references.pmid: 19196922
references.citation: J Comp Neurol. 1996 Sep 09;373(1):90-107
references.pmid: 8876465
references.citation: Ann N Y Acad Sci. 1996 Jun 19;781:532-40
references.pmid: 8694442
references.citation: J Comp Neurol. 1982 Aug 1;209(2):139-75
references.pmid: 7130451
references.citation: J Neurosci. 1986 Feb;6(2):346-54
references.pmid: 3485189
references.citation: Neurosci Lett. 1989 Oct 23;105(1-2):27-33
references.pmid: 2484730
references.citation: Prog Brain Res. 2003;142:69-89
references.pmid: 12693255
references.citation: J Comp Neurol. 1994 Nov 15;349(3):428-47
references.pmid: 7852634
references.citation: J Comp Neurol. 1991 Jun 8;308(2):224-48
references.pmid: 1716269
references.citation: J Neurophysiol. 2002 Apr;87(4):1836-49
references.pmid: 11929905
references.citation: Exp Brain Res. 2002 Feb;142(4):439-62
references.pmid: 11845241
references.citation: Neuroimage. 1999 Sep;10(3 Pt 1):233-60
references.pmid: 10458940
references.citation: Exp Brain Res. 1989;74(1):63-79
references.pmid: 2924842
references.citation: Cortex. 2011 Jan;47(1):59-80
references.pmid: 19833328
references.citation: Brain Res. 1984 Mar 5;294(2):281-98
references.pmid: 6200186
references.citation: J Physiol. 1977 Mar;265(3):833-54
references.pmid: 300801
references.citation: J Comp Neurol. 1989 Jan 22;279(4):629-52
references.pmid: 2465324
references.citation: J Neurophysiol. 1999 Sep;82(3):1178-86
references.pmid: 10482737
references.citation: Clin Physiol Funct Imaging. 2009 Jul;29(4):245-54
references.pmid: 19281500
references.citation: Brain Res. 1983 Aug 1;272(1):37-48
references.pmid: 6616198
references.citation: Ann N Y Acad Sci. 2009 May;1164:19-28
references.pmid: 19645876
references.citation: Proc Natl Acad Sci U S A. 2008 May 20;105(20):7309-14
references.pmid: 18477700
references.citation: Ann N Y Acad Sci. 2009 May;1164:282-92
references.pmid: 19645913
references.citation: Exp Brain Res. 1994;102(1):57-68
references.pmid: 7895799
references.citation: Neuroscience. 2002;110(3):527-40
references.pmid: 11906791
references.citation: Cereb Cortex. 2010 Jan;20(1):214-28
references.pmid: 19465740
references.citation: J Comp Neurol. 1994 Nov 1;349(1):111-28
references.pmid: 7852621
references.citation: Brain. 2003 Jul;126(Pt 7):1562-78
references.pmid: 12805122
references.citation: J Neurophysiol. 1980 Dec;44(6):1058-76
references.pmid: 7452323
references.citation: Cerebellum. 2010 Jun;9(2):174-82
references.pmid: 20012388
references.citation: Prog Brain Res. 2000;124:221-32
references.pmid: 10943128
references.citation: Neuroimage. 2002 Nov;17(3):1315-24
references.pmid: 12414271
references.citation: J Physiol. 1990 Sep;428:595-614
references.pmid: 2231425
references.citation: Prog Brain Res. 2003;142:19-33
references.pmid: 12693252
references.citation: Prog Brain Res. 1979;50:653-65
references.pmid: 551460
references.citation: Brain Res Bull. 1996;41(1):1-29
references.pmid: 8883912
references.citation: Brain Res Dev Brain Res. 2003 Feb 16;140(2):223-36
references.pmid: 12586428
references.citation: Neurosci Res. 1991 May;10(4):290-5
references.pmid: 1652724
references.citation: J Comp Neurol. 1992 Jun 15;320(3):398-414
references.pmid: 1377203
references.citation: J Neurophysiol. 1988 Mar;59(3):952-77
references.pmid: 3367205
references.citation: Prog Neurobiol. 2004 Jan;72(1):27-53
references.pmid: 15019175
references.citation: J Physiol. 1994 Jul 1;478 ( Pt 1):37-54
references.pmid: 7965834