Proteomics and systems biology: application in drug discovery and development.
Studies of complex biological systems aimed at understanding their functions at a global level are the goals of systems biology. Proteomics, generally regarded as the comprehensive study of the expression of all the proteins at a particular time in different organs, tissues, and cell types is a key enabling technology for the systems biology approach. Rapid advances in this regard have been made following the success of the human genome project as well as those of various animals and microorganisms. Possibly, one of the most promising outcomes from studies on the human genome and proteome is the identification of potential new drugs for the treatment of different diseases and tailoring the drugs for individualized patient therapy. Following the identification of a new drug candidate, knowledge on organ and system-level responses helps prioritize the drug targets and design clinical trials based on their efficacy and safety. Toxicoproteomics is playing an important role in that respect. In essence, over the past decade, proteomics has played a major role in drug discovery and development. In this review article, we explain systems biology, discuss the current proteomic technologies, and highlight some important applications of proteomics and systems biology approaches in drug discovery and development.
Chakravarti
Bulbul
B
Department of Biology and Department of Chemistry, York College, City University of New York, New York, CA, USA. bulbul_chakravarti@kgi.edu
Mallik
Buddhadeb
B
Chakravarti
Deb N
DN
D000818:Animals; D002986:Clinical Trials as Topic; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D049490:Systems Biology / Q000379:methods*; D014116:Toxicology
D010750:Phosphoproteins