Planar cell polarity signaling, cilia and polarized ciliary beating.
Planar cell polarity signaling governs a wide array of polarized cell behaviors in animals. Recent reports now show that PCP signaling is essential for the directional beating of motile cilia. Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very different ways. This review will synthesize these recent papers and place them in context with previous studies of PCP signaling in polarized cellular morphogenesis and collective cell movement.
Wallingford
John B
JB
Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology & Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C1000, TX 78712, USA. wallingford@mail.utexas.edu
D000818:Animals; D016764:Cell Polarity; D002923:Cilia / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction
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