title: Online coupling of enantioselective capillary gas chromatography with proton nuclear magnetic resonance spectroscopy.
abstract: The hyphenation of enantioselective capillary gas chromatography and mass spectrometry is not always sufficient to distinguish between structural isomers, thus requiring peak identification by NMR spectroscopy. Here the first online coupling of enantioselective capillary gas chromatography with proton nuclear resonance spectroscopy is described for the unfunctionalized chiral alkane 2,4-dimethylhexane resolved on octakis(6-O-methyl-2,3-di-O-pentyl)-gamma-cyclodextrin at 60 degrees C. NMR allows constitutional and configurational isomers (diastereomers and enantiomers) to be distinguished. Enantiomers display identical spectra at different retention times, which enable an indirect identification of these unfunctionalized alkanes. The presented method is still at an early development stage, and will require instrumental optimization in the future.
authors.affiliation: Institute of Organic Chemistry, University of Tübingen, Tübingen D-72076, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Kühnle
authors.forename: Diana
authors.initials: D
authors.lastname: Kreidler
authors.forename: Karsten
authors.initials: K
authors.lastname: Holtin
authors.forename: Harri
authors.initials: H
authors.lastname: Czesla
authors.forename: Paul
authors.initials: P
authors.lastname: Schuler
authors.forename: Volker
authors.initials: V
authors.lastname: Schurig
authors.forename: Klaus
authors.initials: K
authors.lastname: Albert