title: Pharmacokinetics, antifungal activity and clinical efficacy of anidulafungin in the treatment of fungal infections.
abstract: BACKGROUND
  Anidulafungin is one of three available intravenous echinocandins that plays an important role in the treatment of serious fungal infections. Currently, anidulafungin is approved for the treatment of esophageal candidiasis, candidemia and other invasive Candida infections including intra-abdominal abscesses and peritonitis.
  
  
  METHODS
  This paper covers a comprehensive review of anidulafungin.
  
  
  RESULTS
  The reader will be provided the most recent data available regarding the pharmacology, pharmacokinetics, in vitro activity and clinical utility of anidulafungin for the treatment of serious fungal infections.
  
  
  CONCLUSIONS
  Echinocandin antifungals, such as anidulafungin, are now considered first line for the treatment of candidemia and invasive candidiasis, particularly in critically ill patients or those who have previously received azole therapy. Anidulafungin has potent in vitro activity against Candida and Aspergillus species, predictable pharmacokinetics that does not require dosage adjustment, few drug interactions and is well tolerated. Because of these favorable characteristics, anidulafungin is an important addition to our antifungal armamentarium.
authors.affiliation: University of Connecticut School of Pharmacy, Storrs, CT, USA.
authors.forename: Effie L
authors.initials: EL
authors.lastname: Kuti
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Kuti
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D054714:Echinocandins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin
references.citation: Diagn Microbiol Infect Dis. 2003 Feb;45(2):131-5
references.pmid: 12614985
references.citation: Antimicrob Agents Chemother. 2005 Dec;49(12):5058-68
references.pmid: 16304173
references.citation: Antimicrob Agents Chemother. 2005 Feb;49(2):767-9
references.pmid: 15673762
references.citation: Antimicrob Agents Chemother. 2009 Sep;53(9):3690-9
references.pmid: 19546367
references.citation: Antimicrob Agents Chemother. 2009 Jan;53(1):112-22
references.pmid: 18955538
references.citation: J Clin Microbiol. 2008 Aug;46(8):2620-9
references.pmid: 18579718
references.citation: J Electron Microsc (Tokyo). 2002;51(4):247-55
references.pmid: 12227555
references.citation: Antimicrob Agents Chemother. 2010 Jun;54(6):2497-506
references.pmid: 20385855
references.citation: J Antibiot (Tokyo). 1990 Apr;43(4):433-7
references.pmid: 2141016
references.citation: Antimicrob Agents Chemother. 2008 May;52(5):1873-5
references.pmid: 18347112
references.citation: Drug Resist Updat. 2007 Jun;10(3):121-30
references.pmid: 17569573
references.citation: Clin Infect Dis. 2005 Nov 15;41(10):1455-60
references.pmid: 16231257
references.citation: J Clin Pharmacol. 2007 Mar;47(3):305-14
references.pmid: 17322142
references.citation: Antimicrob Agents Chemother. 2008 Jul;52(7):2305-12
references.pmid: 18443110
references.citation: Antimicrob Agents Chemother. 2009 Mar;53(3):1149-56
references.pmid: 19029327
references.citation: Ther Clin Risk Manag. 2007 Mar;3(1):71-97
references.pmid: 18360617
references.citation: Clin Infect Dis. 2009 Mar 1;48(5):503-35
references.pmid: 19191635
references.citation: Antimicrob Agents Chemother. 2005 Nov;49(11):4795-7
references.pmid: 16251335
references.citation: J Clin Pharmacol. 2005 Dec;45(12):1373-82
references.pmid: 16291712
references.citation: Eur J Clin Microbiol Infect Dis. 1988 Dec;7(6):732-5
references.pmid: 2850912
references.citation: Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):573-81
references.pmid: 17696807
references.citation: J Clin Microbiol. 2009 Jun;47(6):1942-6
references.pmid: 19386851
references.citation: N Engl J Med. 2007 Jun 14;356(24):2472-82
references.pmid: 17568028
references.citation: Antimicrob Agents Chemother. 2008 Feb;52(2):539-50
references.pmid: 18070979
references.citation: J Clin Microbiol. 1998 Oct;36(10):2950-6
references.pmid: 9738049
references.citation: J Acquir Immune Defic Syndr. 2008 Jul 1;48(3):304-9
references.pmid: 18545153
references.citation: Antimicrob Agents Chemother. 2007 Jun;51(6):2253-6
references.pmid: 17420211
references.citation: J Electron Microsc (Tokyo). 2005 Jan;54(1):67-77
references.pmid: 15695488
references.citation: Antimicrob Agents Chemother. 2005 Dec;49(12):5146-8
references.pmid: 16304189
references.citation: Antimicrob Agents Chemother. 2009 Sep;53(9):4035-9
references.pmid: 19596890
references.citation: Int J Antimicrob Agents. 2009 Sep;34(3):282-3
references.pmid: 19369040
references.citation: Antimicrob Agents Chemother. 2005 Aug;49(8):3572-4
references.pmid: 16048988
references.citation: Antimicrob Agents Chemother. 2009 Dec;53(12):5102-7
references.pmid: 19770284
references.citation: J Clin Microbiol. 2009 Oct;47(10):3323-5
references.pmid: 19710267
references.citation: Antimicrob Agents Chemother. 2006 Sep;50(9):3160-1
references.pmid: 16940118
references.citation: J Clin Microbiol. 2006 Mar;44(3):760-3
references.pmid: 16517851
references.citation: Clin Microbiol Infect. 2009 Mar;15(3):274-9
references.pmid: 19210699
references.citation: Antimicrob Agents Chemother. 2008 Jan;52(1):321-8
references.pmid: 17938191
references.citation: Antimicrob Agents Chemother. 2008 Jul;52(7):2673-6
references.pmid: 18443124
references.citation: Antimicrob Agents Chemother. 2005 Feb;49(2):830-2
references.pmid: 15673781
references.citation: Antimicrob Agents Chemother. 2010 Jan;54(1):426-39
references.pmid: 19884370
references.citation: Pharmacotherapy. 2009 Jan;29(1):17-30
references.pmid: 19113794
references.citation: Antimicrob Agents Chemother. 1997 Apr;41(4):863-5
references.pmid: 9087508
references.citation: Antimicrob Agents Chemother. 2006 Nov;50(11):3695-700
references.pmid: 16954319
references.citation: Antimicrob Agents Chemother. 1994 Jul;38(7):1480-9
references.pmid: 7979276
references.citation: Antimicrob Agents Chemother. 1996 Aug;40(8):1811-6
references.pmid: 8843286
references.citation: Antimicrob Agents Chemother. 2004 Jun;48(6):2021-4
references.pmid: 15155194
references.citation: Curr Med Res Opin. 2009 Feb;25(2):385-93
references.pmid: 19192983
references.citation: J Infect Dis. 2004 Oct 15;190(8):1464-71
references.pmid: 15378439
references.citation: J Clin Pharmacol. 2004 Jun;44(6):590-8
references.pmid: 15145966
references.citation: Antimicrob Agents Chemother. 1997 Nov;41(11):2471-9
references.pmid: 9371352
references.citation: Clin Infect Dis. 2004 Sep 15;39(6):770-5
references.pmid: 15472806
references.citation: Antimicrob Agents Chemother. 2008 Apr;52(4):1556-8
references.pmid: 18212099
references.citation: Curr Opin Pharmacol. 2007 Oct;7(5):491-7
references.pmid: 17616480
references.citation: Antimicrob Agents Chemother. 1998 Apr;42(4):873-8
references.pmid: 9559799
references.citation: Antimicrob Agents Chemother. 2009 May;53(5):2005-13
references.pmid: 19237647
references.citation: J Clin Pharmacol. 2005 Feb;45(2):227-33
references.pmid: 15647416
references.citation: J Clin Pharmacol. 2007 Apr;47(4):461-70
references.pmid: 17389555
references.citation: Antimicrob Agents Chemother. 2009 Feb;53(2):794-5
references.pmid: 19064891
references.citation: Antimicrob Agents Chemother. 2003 Apr;47(4):1376-81
references.pmid: 12654673
references.citation: Antimicrob Agents Chemother. 2010 Feb;54(2):943-4
references.pmid: 19933794
references.citation: J Antimicrob Chemother. 2010 Feb;65(2):374-6
references.pmid: 19996140
references.citation: Antimicrob Agents Chemother. 2006 Feb;50(2):632-8
references.pmid: 16436720
references.citation: Clin Infect Dis. 2004 Aug 1;39(3):309-17
references.pmid: 15306996
references.citation: Antimicrob Agents Chemother. 1998 Nov;42(11):2898-905
references.pmid: 9797223
references.citation: J Clin Microbiol. 2010 May;48(5):1592-9
references.pmid: 20335424
references.citation: Antimicrob Agents Chemother. 2009 Jun;53(6):2382-91
references.pmid: 19307368
references.citation: Antimicrob Agents Chemother. 2007 May;51(5):1616-20
references.pmid: 17307976
references.citation: Antimicrob Agents Chemother. 2005 Feb;49(2):721-7
references.pmid: 15673756
references.citation: Antimicrob Agents Chemother. 2001 Oct;45(10):2845-55
references.pmid: 11557479
references.citation: Drug Resist Updat. 2011 Jun;14(3):164-76
references.pmid: 21353623
references.citation: Antimicrob Agents Chemother. 2000 Dec;44(12):3381-8
references.pmid: 11083644
references.citation: Expert Opin Drug Saf. 2006 Nov;5(6):751-8
references.pmid: 17044802
references.citation: J Med Chem. 1995 Aug 18;38(17):3271-81
references.pmid: 7650681