title: Burden on UK secondary care of rotavirus disease and seasonal infections in children.
abstract: OBJECTIVE
  Rotavirus is a common infection affecting children under 5 years, which leads to a significant disease burden. This burden is potentially exacerbated by the seasonality of rotavirus, particularly in the context of the seasonality of other common childhood infections. The primary study objective was to describe the pattern and burden of seasonal infections amongst children under 5 years of age with particular attention placed on rotavirus and other gastrointestinal infections.
  
  
  METHODS
  A retrospective analysis of all routine inpatient data relating to selected seasonal infections in the UK was conducted between 2001/02 and 2007/08 using data from Capse Healthcare Knowledge Systems (CHKS, England, Northern Ireland and Wales) and Information Services Division (ISD, Scotland). Admissions with selected diagnoses were extracted based on International Classification of Diseases (ICD)-10 coding. All episodes were processed using a HRG grouper and costs applied according to the NHS National Tariff.
  
  
  RESULTS
  In the financial year 2007/08, the total number of admissions in the UK for children under 5 years for the selected seasonal infections was 64,879 of which 32,126 admissions were associated with gastrointestinal infections including rotavirus gastroenteritis (RVGE). Seasonal peaks of gastrointestinal infections and RVGE occurred in the spring quarter and respiratory syncytial virus (RSV) and influenza in the winter quarter. Admissions for gastrointestinal infection including RVGE accounted for 35 003 bed days with 9922 due to RVGE. The total cost for admissions involving a diagnosis of seasonal infection was £56 million. Of this, it was estimated that infections with an ICD-10 classification of rotavirus represented a cost of £8.6 million.
  
  
  CONCLUSIONS
  Rotavirus contributes to the significant burden that seasonal infections place on inpatient paediatric resources during the winter and spring months. This study may be limited by issues of clinical coding and the infrequency of confirmatory microbiological testing in real-world practice. Vaccination might be considered as a means of reducing this clinical and economic burden particularly where long-term effectiveness and ease of administration are proven.
authors.affiliation: Cardiff Research Consortium Ltd, UK. rhys.pockett@capita.co.uk
authors.forename: Christopher
authors.initials: C
authors.lastname: Morgan
authors.forename: Nick
authors.initials: N
authors.lastname: Adlard
authors.forename: Stuart
authors.initials: S
authors.lastname: Carroll
authors.forename: Latha
authors.initials: L
authors.lastname: Parvataneni
mesh_terms: D002675:Child, Preschool; D017281:Cost of Illness; D003695:Delivery of Health Care / Q000191:economics*; D005759:Gastroenteritis / Q000191:economics / Q000453:epidemiology / Q000821:virology; D017048:Health Care Costs; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000191:economics* / Q000453:epidemiology / Q000628:therapy; D007297:Inpatients; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000191:economics* / Q000453:epidemiology / Q000628:therapy; D012621:Seasons; D006113:United Kingdom / Q000453:epidemiology