Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain.
Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.
Matsuoka
Tadasu
T
Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Sumiyoshi
Tomiki
T
Tsunoda
Masahiko
M
Takasaki
Ichiro
I
Tabuchi
Yoshiaki
Y
Uehara
Takashi
T
Itoh
Hiroko
H
Suzuki
Michio
M
Kurachi
Masayoshi
M
D000818:Animals; D015870:Gene Expression; D005786:Gene Expression Regulation; D008297:Male; D009186:Myelin Sheath / Q000235:genetics*; D009836:Oligodendroglia; D020411:Oligonucleotide Array Sequence Analysis; D017397:Prefrontal Cortex / Q000254:growth & development*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics; D012741:Sexual Maturation / Q000235:genetics*
J Neurosci. 2005 Jun 1;25(22):5376-81
15930386
Biol Psychiatry. 2005 Dec 15;58(12):921-9
16043134
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):3-18
12732219
Methods. 2010 Apr;50(4):S1-5
20215014
Neurobiol Dis. 2006 Mar;21(3):531-40
16213148
Schizophr Res. 2002 May 1;55(1-2):41-54
11955962
Synapse. 2008 Jan;62(1):1-7
17948890
Lancet. 2003 Sep 6;362(9386):798-805
13678875
Nat Neurosci. 1999 Oct;2(10):861-3
10491603
Nature. 1997 Feb 13;385(6617):634-6
9024661
J Cell Biochem. 2007 Dec 15;102(6):1472-85
17440958
Nat Rev Neurosci. 2008 Dec;9(12):947-57
19002191
Schizophr Res. 2005 Sep 15;77(2-3):261-70
15890497
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4746-51
11296301
BMC Med Genomics. 2009 May 20;2:28
19457239
Neuropsychopharmacology. 1993 Aug;9(1):67-75
8397725
Ann Neurol. 1987 Jun;21(6):530-9
3606042
Cereb Cortex. 2005 Feb;15(2):187-93
15238436