Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for sustained drug delivery.
In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery.
Jain
Subheet
S
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. subheetjain@rediffmail.com
Kaur
Amanpreet
A
Puri
Richa
R
Utreja
Puneet
P
Jain
Anubhuti
A
Bhide
Mahesh
M
Ratnam
Rakesh
R
Singh
Vinay
V
Patil
A S
AS
Jayaraman
N
N
Kaushik
Gaurav
G
Yadav
Subodh
S
Khanduja
K L
KL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage; D008297:Male; D051379:Mice; D013055:Spectrophotometry, Infrared
D000894:Anti-Inflammatory Agents, Non-Steroidal; D050091:Dendrimers; D004337:Drug Carriers; D007660:Ketoprofen