Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.
Four highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1, 3 and 4, wherein, 3 showed activity with an EC(50) value of 0.13μg/mL and a therapeutic index (TI) of 75.1.
Zhang
Ling
L
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Luo
Rong-Hua
RH
Wang
Fei
F
Dong
Ze-Jun
ZJ
Yang
Liu-Meng
LM
Zheng
Yong-Tang
YT
Liu
Ji-Kai
JK
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry
D019380:Anti-HIV Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C554984:trigonothyrin D; C554985:trigonothyrin E; C011309:mezerein