title: High body mass index in adolescent girls precedes psoriasis hospitalization.
abstract: Psoriasis is associated with being overweight, but the temporal relationship is not known. This historical cohort study tested whether severe psoriasis resulting in hospitalization in adulthood was preceded by excess increase in age-adjusted body mass index, a known risk factor in childhood for being overweight in adulthood. The study cohort was based on the Copenhagen School Health Records Register, birth years 1930 to 1984 (309,152 schoolchildren). Cases were found through the Danish National Patient Register for the period 1977 to 2001. A total of 1074 (0.36%) of the schoolchildren were identified as having psoriasis, with at least one hospital admission. Multivariate analysis demonstrated an association between excess increase in body mass index and psoriasis in females only. Being overweight in adolescence was the main factor behind this observation. The female group showed a significant association between psoriasis and body mass index at ages 12 (p = 0.028) and 13 years (p = 0.010). This was not the case for males or for body mass index measured at ages 11 years and below.
authors.affiliation: Department of Dermatology, Roskilde Hospital, Roskilde, Dernmark. lebr@regionsjaelland.dk
authors.forename: Lars Erik
authors.initials: LE
authors.lastname: Bryld
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
authors.forename: Klaus Kaae
authors.initials: KK
authors.lastname: Andersen
authors.forename: Gregor B E
authors.initials: GB
authors.lastname: Jemec
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Baker
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D016013:Likelihood Functions; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000209:etiology*; D011565:Psoriasis / Q000453:epidemiology* / Q000209:etiology*; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors