title: Prevalence of hematological abnormalities in patients with Sheehan's syndrome: response to replacement of glucocorticoids and thyroxine.
abstract: Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients with Sheehan's syndrome. Forty patients of Sheehan's syndrome and an equal number of age and parity matched healthy controls were studied for prevalence of hematological abnormalities. Hemoglobin concentration, hematocrit, red cell, white cell and platelet count were significantly decreased in patients with Sheehan's syndrome compared to controls. Frequency of anemia, leucopenia, thrombocytopenia and pancytopenia was significantly higher in these patients compared to controls. After achieving euthyroid and eucortisol state, there was a complete recovery of these hematological abnormalities. We conclude that anemia and other cytopenias are common in patients with Sheehan's syndrome and replacement with thyroxine and glucocorticoids results in complete recovery of these abnormalities.
authors.affiliation: Department of Endocrinology, Sher-I- Kashmir Institute of Medical Sciences Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.forename: Shahnaz Ahmad
authors.initials: SA
authors.lastname: Mir
authors.forename: Mir Iftikhar
authors.initials: MI
authors.lastname: Bashir
authors.forename: Javid Rasool
authors.initials: JR
authors.lastname: Bhat
authors.forename: Jeelani
authors.initials: J
authors.lastname: Samoon
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Zargar
mesh_terms: D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000188:drug therapy* / Q000196:embryology*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000196:embryology*; D008297:Male; D010198:Pancytopenia / Q000188:drug therapy / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D013974:Thyroxine
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