title: Sesame oil accelerates kidney healing following gentamicin-induced kidney injury in rats.
abstract: OBJECTIVE
  We investigated the therapeutic effect of a single dose of sesame oil against gentamicin-induced renal damage in rats.
  
  
  METHODS
  Experimental rats were subcutaneously injected with gentamicin (100 mg/kg/day for 7 days) to induce renal injury. Sesame oil (1, 2 or 4 ml/kg) was given orally 24 h after the last dose of gentamicin. Control rats were treated with saline only. Renal injury, histopathological examination, histochemical staining, osteopontin expression, superoxide anion, nitric oxide, peroxynitrite radical and lipid peroxidation were assessed 24 h after sesame oil administration.
  
  
  RESULTS
  Serum blood urea nitrogen and creatinine as well as renal osteopontin expression, superoxide anion, nitric oxide, peroxynitrite radical and lipid peroxidation levels were higher in gentamicin-treated rats than in control rats. Sesame oil significantly decreased all the tested parameters compared with gentamicin-alone rats. Furthermore, histopathological and histochemical staining showed that renal tubules had recovered and regenerated in the sesame oil-treated rats.
  
  
  CONCLUSIONS
  We hypothesize that a single dose of sesame oil inhibits oxidative stress to shorten the recovery period and allow the regeneration of renal tubules after the onset of gentamicin-induced renal injury in rats.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University College of Medicine, Tainan, Taiwan, ROC.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Periasamy
authors.forename: Chuan-Teng
authors.initials: CT
authors.lastname: Liu
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D049109:Cell Proliferation / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D005839:Gentamicins; D017665:Hydroxyl Radical / Q000378:metabolism; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009573:Nitrites / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012715:Sesame Oil / Q000494:pharmacology / Q000627:therapeutic use*; D013481:Superoxides / Q000378:metabolism
chemical_list: D005839:Gentamicins; D009573:Nitrites; D053495:Osteopontin; D013481:Superoxides; D017665:Hydroxyl Radical; D012715:Sesame Oil; D003404:Creatinine