title: Sol-gel phosphate-based glass for drug delivery applications.
abstract: Development of controlled, targeted drug delivery systems represents one of the frontier areas of biomaterials science, where a multidisciplinary approach is of direct benefit to human healthcare. We demonstrate herein the potential of sol-gel derived phosphate-based glass for use in drug delivery applications. Our low-temperature sol-gel synthesis of phosphate-based glasses has made it possible to incorporate relatively unstable functional molecules for controlled release. We demonstrate the potential of this approach by incorporating the chemotherapy agent cisplatin in a CaO-Na(2)O-P(2)O(5) glass. X-ray absorption spectroscopy is used to show that the chlorine ligands of cisplatin undergo exchange with oxygen during the synthesis, consistent with binding to the phosphate groups of the sol-gel. UV-visible spectroscopy reveals the subsequent release of cisplatin into an aqueous medium.
authors.affiliation: School of Physical Sciences, Ingram Building, University of Kent Canterbury, Kent, CT2 7NH, UK. dmp@kent.ac.uk
authors.forename: David M
authors.initials: DM
authors.lastname: Pickup
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Newport
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D044367:Phase Transition; D010710:Phosphates / Q000737:chemistry*; D056928:X-Ray Absorption Spectroscopy
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D010710:Phosphates; D002945:Cisplatin