Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.
Little is known about the role of GABA(B) receptors (GABA(B)Rs) in the maintenance of memories associated with using abused substances. We have embarked on a series of studies designed to determine if enhancing the efficacy of GABA-occupied GABA(B)Rs with positive allosteric modulators (PAMs) can negate previously established conditioned place preference (CPP) induced by methamphetamine. In the current study, we evaluated the effects of acute administration of GABA(B)R PAMs, GS39783 and CGP7930. We determined that post-conditioning treatments with these PAMs, administered in the home cage, blocked the subsequent expression of methamphetamine-induced CPP. These data indicate that selectively augmenting GABA-occupied GABA(B)R signaling is sufficient to reduce memory maintenance and/or the salience of contextual cues previously associated with methamphetamine.
Voigt
Robin M
RM
Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, United States. rvoigt@lumc.edu
Herrold
Amy A
AA
Riddle
Jennifer L
JL
Napier
T Celeste
TC
D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D003213:Conditioning, Psychological / Q000187:drug effects*; D003517:Cyclopentanes / Q000494:pharmacology; D058786:GABA-B Receptor Agonists / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D010636:Phenols / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
C438607:2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol; D000697:Central Nervous System Stimulants; D003517:Cyclopentanes; D058786:GABA-B Receptor Agonists; C478058:N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine; D010636:Phenols; D011743:Pyrimidines; D008694:Methamphetamine
Behav Pharmacol. 2004 Sep;15(5-6):397-401
15343066
Ann N Y Acad Sci. 1992 Jun 28;654:400-15
1632593
Psychopharmacology (Berl). 2005 Feb;177(4):409-17
15630589
Neuropsychopharmacology. 1998 May;18(5):403-4
9536455
J Neurochem. 2006 Mar;96(5):1416-22
16441514
Neuroreport. 2002 Jul 2;13(9):1107-10
12151750
Pharmacol Biochem Behav. 1996 Feb;53(2):303-8
8808136
Psychopharmacology (Berl). 1992;107(4):523-9
1603895
Mol Neurobiol. 2007 Feb;35(1):95-112
17519508
Neuropharmacology. 2005 Mar;48(3):343-53
15721166
Prog Neurobiol. 1998 Dec;56(6):613-72
9871940
Pharmacol Biochem Behav. 2004 Oct;79(2):343-8
15501311
Neuropsychopharmacology. 2007 Feb;32(2):388-98
16710312
J Clin Psychiatry. 2003 Dec;64(12):1440-8
14728105
Eur J Neurosci. 2005 Apr;21(7):2035-9
15869498
Eur J Pharmacol. 2007 Nov 28;574(2-3):148-57
17698060
Psychopharmacology (Berl). 2004 Apr;173(1-2):105-11
14712341
Biol Psychiatry. 2009 May 15;65(10):900-4
19111278
Drug Alcohol Depend. 2007 Jan 5;86(1):55-66
16762517
Drug Alcohol Depend. 2009 Jan 1;99(1-3):231-9
18945553
PLoS One. 2008 Jan 30;3(1):e1506
18231593
Life Sci. 2001 Jul 20;69(9):1093-102
11508652
Life Sci. 2001 Dec 7;70(3):349-56
12005267
Psychopharmacology (Berl). 1987;92(3):398-401
2819919
Behav Neural Biol. 1989 Sep;52(2):170-9
2552976
Ann Clin Psychiatry. 2008 Jul-Sep;20(3):145-55
18633741
Alcohol Alcohol. 2002 Sep-Oct;37(5):478-84
12217943
Mol Pharmacol. 2001 Nov;60(5):963-71
11641424
J Pharmacol Exp Ther. 2004 Sep;310(3):952-63
15113848
Eur Neuropsychopharmacol. 2004 Jan;14(1):59-64
14659988
Brain Res. 1995 Jun 19;683(2):209-14
7552356
Eur Neuropsychopharmacol. 2009 Jul;19(7):487-98
19250803
J Neurochem. 2002 Nov;83(3):645-54
12390526
Drug Alcohol Depend. 2007 Jul 10;89(2-3):206-13
17234367
Psychopharmacology (Berl). 2009 Jan;202(1-3):403-9
18695929
Synapse. 2009 Feb;63(2):87-94
19016239
Eur J Pharmacol. 2008 Dec 3;599(1-3):58-64
18848829
Eur J Pharmacol. 2007 Oct 1;571(2-3):166-73
17610868
Pharmacol Rep. 2008 Nov-Dec;60(6):834-43
19211975
Drug Alcohol Depend. 2006 Dec 1;85(3):177-84
16740370
Psychopharmacology (Berl). 2005 May;179(3):688-99
15668819
Physiol Rev. 2004 Jul;84(3):835-67
15269338
Behav Neural Biol. 1994 Mar;61(2):181-5
8204084
J Comp Neurol. 1999 Mar 15;405(3):299-321
10076927
Am J Psychiatry. 1999 Jan;156(1):11-8
9892292
Curr Drug Abuse Rev. 2008 Nov;1(3):303-27
19430578
J Psychopharmacol. 2002 Dec;16(4):313-9
12503830
Behav Pharmacol. 2005 Nov;16(7):553-8
16170232
Addict Biol. 2007 Sep;12(3-4):227-462
17678505