[New alkyl cationic glycerolipids with heterocyclic polar domain are responsible for disorders in the leukemia cells cycle and cells apoptosis].
A series of new modifications of alkyl cationic glycerolipids with hetero polar domain has been synthesized. The most active compound rac-N-(4-[(2-ethoxy-3-octadecyloxy)prop-1-yloxycarbonyl]butyl)-N'-etylimidazoliyiodid in micromolar concentrations causes a delay of cell cycle in phase G1, DNA fragmentation and apoptosis of cell line leukemia.
Markova
A A
AA
Pliavnik
N V
NV
Tatarskiĭ
V V
VV
Shtil'
A A
AA
Serebrennikova
G A
GA
D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects*; D016193:G1 Phase / Q000187:drug effects*; D005989:Glycerides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism*
D005989:Glycerides; D006571:Heterocyclic Compounds