title: Development of a nomogram for identification of asthma among adults in epidemiologic studies.
abstract: BACKGROUND
  The criteria used to identify persons with asthma in epidemiologic studies are varying and, depending on the method used, can be challenging and resource consuming.
  
  
  OBJECTIVE
  To develop a nomogram (scoring system) to identify adult patients with asthma using a combination of variables collected via a validated questionnaire.
  
  
  METHODS
  We studied the first 268 women aged 40 to 69 years in the Shanghai Women's Asthma and Allergy Study who reported signs and symptoms of asthma and underwent either methacholine challenge testing or test of reversibility during the asthma screening survey between 2003 and 2007. These women were defined as having definite asthma (n=106) or not (n=162). Multivariable logistic regression analysis was performed to develop a predictive model for identifying asthma using survey information alone.
  
  
  RESULTS
  Clinically relevant questions were used for the predictive multivariable logistic regression model and included the following: ever wheezing or whistling in the chest, current medication use for asthma, self-reported ever asthma, self-reported ever allergic rhinitis, family history of allergy, and age. The area under the receiver operating characteristic curve of the prediction model was 0.75 (95% confidence interval, 0.69-0.81). A nomogram was developed to assess the individual probability of asthma based on individually weighted variables in the predictive model.
  
  
  CONCLUSIONS
  In clinical or epidemiologic studies, this asthma nomogram could be used as a tool to assess the probability of asthma for an individual patient by incorporating asthma-related predictor variables obtained through a field questionnaire.
authors.affiliation: Department of Medicine, Division of Allergy Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8300, USA.
authors.forename: Xinqing
authors.initials: X
authors.lastname: Deng
authors.forename: Tebeb
authors.initials: T
authors.lastname: Gebretsadik
authors.forename: Meiling
authors.initials: M
authors.lastname: Jin
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.forename: John W
authors.initials: JW
authors.lastname: Christman
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wen
authors.forename: William D
authors.initials: WD
authors.lastname: Dupont
authors.forename: Dale
authors.initials: D
authors.lastname: Plummer
authors.forename: Jeremy
authors.initials: J
authors.lastname: Stephens
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Tina V
authors.initials: TV
authors.lastname: Hartert
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D002681:China; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D008875:Middle Aged; D049451:Nomograms; D018579:Patient Selection; D012135:Respiratory Sounds; D012220:Rhinitis; D057566:Self Report
references.citation: Respir Med. 2001 Aug;95(8):685-92
references.pmid: 11530958
references.citation: J Clin Epidemiol. 2003 Mar;56(3):238-47
references.pmid: 12725878
references.citation: Am Rev Respir Dis. 1991 Nov;144(5):1202-18
references.pmid: 1952453
references.citation: Thorax. 2000 May;55(5):352-4
references.pmid: 10770813
references.citation: Eur Respir J. 1997 Nov;10(11):2495-501
references.pmid: 9426085
references.citation: Respir Res. 2005 Dec 28;6:153
references.pmid: 16381607
references.citation: J Investig Allergol Clin Immunol. 1998 Nov-Dec;8(6):376-82
references.pmid: 10028486
references.citation: J Asthma. 2007 Jun;44(5):371-5
references.pmid: 17613632
references.citation: Eur J Epidemiol. 2001;17(1):19-29
references.pmid: 11523572
references.citation: J Clin Oncol. 2008 Mar 10;26(8):1364-70
references.pmid: 18323559
references.citation: Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36
references.pmid: 7663792
references.citation: Lancet. 2006 Aug 26;368(9537):733-43
references.pmid: 16935684
references.citation: Am Rev Respir Dis. 1990 Sep;142(3):549-54
references.pmid: 2202246
references.citation: Respir Med. 2004 Sep;98(9):826-31
references.pmid: 15338793
references.citation: Chest. 2004 May;125(5):1657-64
references.pmid: 15136373
references.citation: J Outcome Meas. 2000-2001;4(4):740-62
references.pmid: 11394584
references.citation: Am Rev Respir Dis. 1992 Sep;146(3):633-7
references.pmid: 1519839
references.citation: Am J Respir Crit Care Med. 2000 Jan;161(1):309-29
references.pmid: 10619836
references.citation: Pediatr Pulmonol. 2007 Jan;42(1):100
references.pmid: 17123321
references.citation: Respir Med. 1997 Feb;91(2):83-8
references.pmid: 9122516
references.citation: Allergy. 2007 Feb;62(2):142-8
references.pmid: 17298422
references.citation: J Korean Med Sci. 2003 Feb;18(1):48-52
references.pmid: 12589086
references.citation: Int J Epidemiol. 1996 Jun;25(3):609-16
references.pmid: 8671563
references.citation: Pediatr Allergy Immunol. 2007 May;18(3):188-95
references.pmid: 17432997
references.citation: Pediatr Allergy Immunol. 1997 May;8(2):75-82
references.pmid: 9617776
references.citation: Eur Respir J. 2005 Jul;26(1):28-35
references.pmid: 15994386
references.citation: Eur Respir J. 1998 Mar;11(3):599-605
references.pmid: 9596109
references.citation: J Pediatr (Rio J). 2006 Sep-Oct;82(5):341-6
references.pmid: 16951799
references.citation: Am Rev Respir Dis. 1986 Sep;134(3):625-7
references.pmid: 3752719
references.citation: Clin Exp Allergy. 2000 Aug;30(8):1181-7
references.pmid: 10931127
references.citation: Am J Epidemiol. 2008 Jun 1;167(11):1387-96
references.pmid: 18397914
references.citation: Eur Respir J. 1999 Oct;14(4):951-7
references.pmid: 10573248
references.citation: Allergy. 1996 May;51(5):331-6
references.pmid: 8836338
references.citation: Ann Allergy Asthma Immunol. 2009 Nov;103(5):363-9; quiz 369-72, 400
references.pmid: 19927533