title: A rapid three-component MgI(2)-mediated synthesis of 3,3-pyrollidinyl spirooxindoles.
abstract: The rapid synthesis of 3,3-pyrollidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.
authors.affiliation: GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Helan
authors.forename: Allie
authors.initials: A
authors.lastname: Mills
authors.forename: David
authors.initials: D
authors.lastname: Drewry
authors.forename: Daniel
authors.initials: D
authors.lastname: Grant
mesh_terms: D007211:Indoles / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D007454:Iodides; D017616:Magnesium Compounds; D013141:Spiro Compounds; C510205:magnesium iodide