Examination of the offspring of a Japanese cow affected with L-type bovine spongiform encephalopathy.
The offspring of a beef cow affected with L-type bovine spongiform encephalopathy (L-BSE) was kept in a pen at a BSE-dedicated animal facility till the offspring was 48 months of age. The steer was then euthanized and subjected to a test for BSE. The abnormal isoform of the prion protein was not detected in the brain and spinal cord of the steer. Transmission of L-BSE was not observed during 4 years of observation, though the steer was born when the dam was in the terminal stages of the disease.
Yokoyama
Takashi
T
Prion Disease Research Center, National Institute of Animal Health, Ibaraki, Japan.
Okada
Hiroyuki
H
Murayama
Yuichi
Y
Masujin
Kentaro
K
Iwamaru
Yoshifumi
Y
Mohri
Shirou
S
D000818:Animals; D001921:Brain / Q000473:pathology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D005260:Female; D008297:Male; D018620:PrPSc Proteins / Q000302:isolation & purification* / Q000378:metabolism; D013116:Spinal Cord / Q000473:pathology
D018620:PrPSc Proteins