A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles.
An efficient and highly versatile method for the synthesis of diverse regiospecific 1-arylbenzotriazoles being important medicinal scaffolds, by the copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes of 2-haloaryldiazonium salts in PEG-water has been developed. A very simple reaction protocol, large number of substrate affordability and excellent yields are the main features of this methodology.
Mukhopadhyay
Chhanda
C
Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata-700009, India. cmukhop@yahoo.co.in
Tapaswi
Pradip Kumar
PK
Butcher
Ray J
RJ
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D011092:Polyethylene Glycols / Q000737:chemistry*; D013237:Stereoisomerism; D014226:Triazenes / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D008024:Ligands; D014226:Triazenes; D014230:Triazoles; D014867:Water; D011092:Polyethylene Glycols; C402345:1,3-diphenyl-1-triazene; D003300:Copper; C012771:benzotriazole