title: Acanthosis nigricans in a patient with lung cancer: a case report.
abstract: Some skin lesions may accompany malignancies. Acanthosis nigricans, one such lesion, is a paraneoplastic dermatosis characterized by hyperpigmented and velvety verrucose plaques observed as symetric eruptions. With this report, we aim to present a rare case of concomitant lung cancer and acanthosis nigricans. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. A 65-year-old patient who had hyperpigmented, hypertrophic and symmetric verrucose lesions at the flexor surfaces of the lower and upper extremities, face, palms and the axillary region. Thoracic computed tomography demonstrated a hypodense mass lesion with a dimension of 5 x 5.5 cm at the center of basal segment bronchi of the left pulmonary lobe. Fiberoptic bronchoscopy showed that the access to the lower left lobe was almost completely obstructed by the endobronchial lesion. The result of the histopathologic examination of the endobronchial tissue biopsy was reported as non-small cell (adenocarcinoma) lung cancer. Result of the histopathologic analysis of the punch biopsy of the skin lesions was reported as acanthosis nigricans .There are no pathognomonic dermatological findings for lung cancer. In conclusion, there are skin lesions that accompany lung cancer and we believe that these should be considered for differential diagnosis.
authors.affiliation: Dişkapi Yildirim Bayazit Education and Reserch Hospital, Chest Diseases Clinic, 06200 Ankara, Turkey.
authors.forename: Duru
authors.initials: D
authors.lastname: Serap
authors.forename: Sever
authors.initials: S
authors.lastname: Ozlem
authors.forename: Yüceege
authors.initials: Y
authors.lastname: Melike
authors.forename: Dilli
authors.initials: D
authors.lastname: Alper
authors.forename: Albayrak
authors.initials: A
authors.lastname: Aynur
authors.forename: Arıkök
authors.initials: A
authors.lastname: Ata Türker
authors.forename: Sadik
authors.initials: S
authors.lastname: Ardıç
references.citation: Thorax. 1988 May;43(5):414-5
references.pmid: 2848329
references.citation: J Am Acad Dermatol. 2000 Feb;42(2 Pt 2):357-62
references.pmid: 10640933
references.citation: Ann Thorac Cardiovasc Surg. 2009 Dec;15(6):397-400
references.pmid: 20081750
references.citation: J Am Acad Dermatol. 1991 Aug;25(2 Pt 2):361-5
references.pmid: 1894773
references.citation: Gynecol Oncol. 2002 Feb;84(2):332-4
references.pmid: 11812096
references.citation: J Am Acad Dermatol. 2003 Sep;49(3):541-3
references.pmid: 12963928
references.citation: Diabetes Care. 2004 Jun;27(6):1412-6
references.pmid: 15161797
references.citation: Dermatologica. 1988;176(3):133-7
references.pmid: 3378650
references.citation: J Dermatol Surg Oncol. 1980 Nov;6(11):923-7
references.pmid: 6257767
references.citation: Int J Dermatol. 2005 Jan;44(1):45-7
references.pmid: 15663660
references.citation: J Am Acad Dermatol. 1994 Jul;31(1):1-19; quiz 20-2
references.pmid: 8021347
references.citation: Pol Arch Med Wewn. 2009 Mar;119(3):180-3
references.pmid: 19514649
references.citation: Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Nov;30(11):1991-5
references.pmid: 1484439
references.citation: Dermatol Clin. 2002 Jul;20(3):523-32
references.pmid: 12170885
references.citation: Cancer. 1962 Mar-Apr;15:364-82
references.pmid: 13882755
references.citation: Diabetes Care. 2002 Jun;25(6):1009-14
references.pmid: 12032107
references.citation: Curr Opin Oncol. 1999 Mar;11(2):139-44
references.pmid: 10188080