An efficient synthesis of hydantoins via sustainable integration of coupled domino processes.
A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).
Gao
Meng
M
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, PR China.
Yang
Yan
Y
Wu
Yan-Dong
YD
Deng
Cong
C
Shu
Wen-Ming
WM
Zhang
Dong-Xue
DX
Cao
Li-Ping
LP
She
Neng-Fang
NF
Wu
An-Xin
AX