Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse.
The Ladybird-like homeobox gene 2 (Lbx2) belongs to the homeodomain-containing family of transcription factor that are known to play crucial role in various developmental processes. During early mouse embryogenesis, Lbx2 was shown to be expressed in the developing eye, brain and urogenital system. Although Lbx2 was detected in the testis and epididymis throughout development, no data was available regarding its expression in the female gonad. Here we have determined Lbx2 expression throughout mouse ovarian development by in situ hybridization. In contrast to the strong expression in the male fetal gonad, no Lbx2 signal could be detected in the fetal ovary. Soon after birth, however, Lbx2 expression was detected at different levels in various ovarian compartments (oocyte, granulosa cells, theca cells) where its expression was highly dynamic depending on the stage of follicular maturation. Our data would be consistent with a role for LBX2 in ovarian maturation and folliculogenesis.
Moisan
Vanessa
V
Reproduction, Perinatal and Child Health, CHUQ Research Centre, CHUL Room T1-49, 2705 Laurier Blvd, Quebec City, QC G1V 4G2, Canada. Vanessa.Moisan@crchul.ulaval.ca
Robert
Nicholas M
NM
Tremblay
Jacques J
JJ
D000375:Aging / Q000378:metabolism; D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D038081:Organogenesis; D006080:Ovarian Follicle / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*
D018398:Homeodomain Proteins; C121637:Lbx2h protein, mouse
Mol Hum Reprod. 2006 May;12(5):283-9
16597639
Mol Cell Endocrinol. 2007 Feb;265-266:3-9
17208359
Gene Expr Patterns. 2006 Mar;6(3):241-6
16378763
Mech Dev. 1995 Nov;53(3):345-56
8645601
Nature. 2000 Feb 24;403(6772):909-13
10706291
Trans Am Clin Climatol Assoc. 2003;114:51-63; discussion 64-5
12813911
Development. 2000 Jan;127(2):413-24
10603357
BMC Dev Biol. 2009 Feb 12;9:13
19216761
Development. 2007 Jan;134(1):199-209
17164425
Development. 1997 May;124(9):1653-64
9165114
Mech Dev. 1999 Jun;84(1-2):181-4
10473138
Cell. 1988 Sep 23;54(7):1081-90
3046753
Development. 1998 Sep;125(18):3699-708
9716535
Hum Mol Genet. 2008 May 1;17(9):1278-91
18250097
Dev Biol. 2004 Dec 15;276(2):431-40
15581876
Cell Mol Life Sci. 2006 Mar;63(5):579-90
16416028
Development. 2004 Feb;131(4):933-42
14736745
Science. 2004 Aug 20;305(5687):1157-9
15326356
Development. 2000 Jan;127(2):437-45
10603359
Hum Mol Genet. 2005 Jul 15;14(14):2053-62
15944199
Nature. 1999 Feb 4;397(6718):405-9
9989404
Mol Reprod Dev. 2005 Dec;72(4):550-6
16155958
Gene. 1993 Dec 15;135(1-2):215-21
7903947
Science. 2003 Jul 11;301(5630):215-8
12855809
Genes Dev. 2009 Aug 1;23(15):1737-42
19651985
BMC Dev Biol. 2008 Feb 27;8:22
18304314
Dev Dyn. 2004 Jun;230(2):210-5
15162500
Nat Genet. 2002 Nov;32(3):359-69
12379852
Biol Reprod. 2008 Sep;79(3):442-9
18509161
BMC Biol. 2007 Oct 26;5:47
17963489
Dev Biol. 2004 Jun 1;270(1):122-34
15136145
Mol Cell Biol. 1988 Nov;8(11):4598-607
2905420
Development. 2000 Nov;127(21):4645-54
11023867
Mech Dev. 2002 Sep;117(1-2):259-63
12204267
Mol Cell Endocrinol. 2005 Jan 31;230(1-2):87-93
15664455
Gene Expr Patterns. 2005 Aug;5(6):756-62
15963769
BMC Dev Biol. 2008 Jul 24;8:72
18651984
N Engl J Med. 2004 Jan 22;350(4):367-78
14736929
Biol Reprod. 1994 Feb;50(2):225-32
8142540
Genesis. 2007 Jun;45(6):361-8
17492753
Hum Reprod Update. 2006 Jan-Feb;12(1):65-76
16143663
Cell. 2005 Feb 11;120(3):369-82
15707895