title: A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation.
abstract: Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3(+)DR(+)-Tregs among the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3(+)DR(+)-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly reduced suppressive activity of their circulating CD4(+)CD127(low+/-)CD25(+)-Treg cell pool. Our findings propose that the FoxP3(+)DR(+)-Treg subset may be decisively responsible for the suppressive activity of the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool and that the immunologic mechanisms leading to preterm labor necessitating preterm delivery may be similar to those leading to allograft rejection after transplantation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, Voss-Strasse 9, 69115 Heidelberg, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Kisielewicz
authors.forename: Matthias
authors.initials: M
authors.lastname: Schaier
authors.forename: Edgar
authors.initials: E
authors.lastname: Schmitt
authors.forename: Friederike
authors.initials: F
authors.lastname: Hug
authors.forename: Gertrud M
authors.initials: GM
authors.lastname: Haensch
authors.forename: Stefan
authors.initials: S
authors.lastname: Meuer
authors.forename: Martin
authors.initials: M
authors.lastname: Zeier
authors.forename: Christof
authors.initials: C
authors.lastname: Sohn
authors.forename: Andrea
authors.initials: A
authors.lastname: Steinborn
mesh_terms: D018791:CD4 Lymphocyte Count; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006084:Graft Rejection / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D053699:Interleukin-7 Receptor alpha Subunit / Q000378:metabolism; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D007752:Obstetric Labor, Premature / Q000276:immunology* / Q000503:physiopathology*; D011247:Pregnancy; D047928:Premature Birth / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D006684:HLA-DR Antigens; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D053699:Interleukin-7 Receptor alpha Subunit