The origins of social impairments in autism spectrum disorder: studies of infants at risk.
Core impairments in social and communicative behaviors are among the defining characteristics of autism spectrum disorder (ASD), making this a model syndrome for investigating the mechanisms that underlie social cognition and behavior. Current research is exploring the origins of social impairments in prospective longitudinal studies of infants who are at high risk for ASD, defined as having an older sibling with the disorder. Behavioral studies that have followed these infants through to outcomes have found that during the early months of life they are no different from typically developing infants; they are socially interested, engaged and enjoy interactions with people. By the end of the first year risk signs for later ASD can be identified though no single marker has been identified. It seems that an aggregate of risk markers together may be needed to predict ASD. Other studies have compared infants at risk for ASD to low risk controls to identify neurocognitive endophenotypes. Several differences in subtle aspects of behavior and in brain organization have been found in infants younger than 12 months, though it is not known whether these differences are also risk markers for a later ASD diagnosis. The findings from these lines of research are used to provide a new view of ASD, as a disorder defined on the basis of alterations in the developmental trajectories across multiple domains. ASD is an emergent disorder that is characterized by the loss of social communication skills in the period between 9 and 24 months. Across children the rate, timing and severity of this loss is highly variable. Future research will lead to a greater understanding of the genetic and neurocognitive mechanisms that underlie these fundamental changes in the developmental patterns of individuals with ASD.
Tager-Flusberg
Helen
H
Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, United States. htagerf@bu.edu
D002657:Child Development; D002659:Child Development Disorders, Pervasive / Q000523:psychology*; D006801:Humans; D007223:Infant; D018730:Infant Behavior; D010641:Phenotype; D012306:Risk; D035781:Siblings; D012920:Social Behavior Disorders / Q000523:psychology*; D009626:Terminology as Topic
Autism Res. 2009 Jun;2(3):125-37
19582867
J Neurosci. 2004 Oct 20;24(42):9228-31
15496656
J Autism Dev Disord. 1994 Jun;24(3):247-57
8050980
Acta Paedopsychiatr. 1968;35(4):100-36
4880460
Prog Brain Res. 2007;164:355-83
17920442
Biol Psychiatry. 2007 Feb 15;61(4):512-20
17069771
Philos Trans R Soc Lond B Biol Sci. 2009 May 27;364(1522):1385-91
19528021
Nat Rev Genet. 2008 May;9(5):341-55
18414403
J Autism Dev Disord. 2007 Jan;37(1):133-44
17186366
Dev Sci. 2010 Jan 1;13(1):244-51
20121880
Arch Pediatr Adolesc Med. 2007 Apr;161(4):378-83
17404135
J Child Psychol Psychiatry. 2009 May;50(5):637-42
19298466
Autism Res. 2009 Feb;2(1):22-38
19358305
Biol Psychiatry. 2005 Jul 1;58(1):1-9
15935993
J Autism Dev Disord. 2007 Jan;37(1):25-36
17219059
Dev Neuropsychol. 2005;27(3):311-36
15843100
J Autism Dev Disord. 2007 Jan;37(1):98-107
17206522
J Autism Dev Disord. 2007 Jan;37(1):158-70
17191097
Adv Child Dev Behav. 2008;36:331-72
18808047
Biol Psychiatry. 2009 Nov 15;66(10):950-7
19765688
Dev Sci. 2009 Sep;12(5):798-814
19702771
J Child Psychol Psychiatry. 2006 Jun;47(6):629-38
16712640
J Autism Dev Disord. 2007 Aug;37(7):1323-36
17180460
Int J Dev Neurosci. 2005 Apr-May;23(2-3):143-52
15749241
J Autism Dev Disord. 1991 Mar;21(1):43-9
2037548
Science. 2009 Jul 17;325(5938):284-8
19608908
Am J Psychiatry. 1997 Feb;154(2):185-90
9016266
J Autism Dev Disord. 2008 Apr;38(4):731-8
17874180
J Autism Dev Disord. 2007 Mar;37(3):466-80
16897376
Biol Psychiatry. 2009 Jan 1;65(1):31-8
19064038
Child Dev. 2008 Nov-Dec;79(6):1606-24
19037935
J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):256-66.e1-2
20410715
Autism. 2008 Sep;12(5):457-72
18805942
J Autism Dev Disord. 2007 Jan;37(1):12-24
17211728
J Cogn Neurosci. 1997 Jul;9(4):548-54
23968217
Dev Psychopathol. 2005 Summer;17(3):679-97
16262987
J Autism Dev Disord. 1999 Jun;29(3):213-24
10425584
J Autism Dev Disord. 2007 Jan;37(1):122-32
17186367
Am J Psychiatry. 2003 Apr;160(4):636-45
12668349
J Autism Dev Disord. 2007 Jan;37(1):108-21
17191096
J Child Psychol Psychiatry. 2009 Jul;50(7):843-52
19527315
J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S69-78
16685188
J Child Psychol Psychiatry. 2006 May;47(5):511-23
16671934