Cell-based biosensors: current trends of the development.
In the last decade, a number of laboratories have developed devices that combine electronic components with living cells, including neurons. These devices can be used as cell-based biosensors or labs-on-a-chip for testing of the tumor cell sensitivity to anti-cancer drugs, detection of toxins and chemical substances and pre-clinical evaluation of new drugs. Here we review briefly the existing types of the cell-based biosensors and the strategies employed to improve these complex devices. We argue that, for the neuron-based biosensors, introduction of structure in the connections of the synaptic network should significantly improve the utility of such devices.
Baranauskas
G
G
Department of Chemistry, Materials and Chemical Engineering ""G.Natta"", Politecnico di Milano, Milano - Italy.
Gusmeroli
R
R
Spinelli
A S
AS
Giordano
C
C
Raimondi
M T
MT