Multiple indicators of ambient and personal ultraviolet radiation exposure and risk of non-Hodgkin lymphoma (United States).
Recent epidemiologic studies have suggested that ultraviolet radiation (UV) may protect against non-Hodgkin lymphoma (NHL), but few, if any, have assessed multiple indicators of ambient and personal UV exposure. Using the US Radiologic Technologists study, we examined the association between NHL and self-reported time outdoors in summer, as well as average year-round and seasonal ambient exposures based on satellite estimates for different age periods, and sun susceptibility in participants who had responded to two questionnaires (1994-1998, 2003-2005) and who were cancer-free as of the earlier questionnaire. Using unconditional logistic regression, we estimated the odds ratio (OR) and 95% confidence intervals for 64,103 participants with 137 NHL cases. Self-reported time outdoors in summer was unrelated to risk. Lower risk was somewhat related to higher average year-round and winter ambient exposure for the period closest in time, and prior to, diagnosis (ages 20-39). Relative to 1.0 for the lowest quartile of average year-round ambient UV, the estimated OR for successively higher quartiles was 0.68 (0.42-1.10); 0.82 (0.52-1.29); and 0.64 (0.40-1.03), p-trend=0.06), for this age period. The lower NHL risk associated with higher year-round average and winter ambient UV provides modest additional support for a protective relationship between UV and NHL.
Freedman
D Michal
DM
National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA. freedmam@mail.nih.gov
Kimlin
Michael G
MG
Hoffbeck
Richard W
RW
Alexander
Bruce H
BH
Linet
Martha S
MS
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014466:Ultraviolet Rays; D014481:United States
BMJ. 1997 May 17;314(7092):1451-5
9167561
Photochem Photobiol. 2010 May-Jun;86(3):481-91
20550646
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1678S-88S
15585788
J Natl Cancer Inst. 2005 Feb 2;97(3):199-209
15687363
Int J Epidemiol. 2006 Apr;35(2):495-7
16330477
Eur J Cancer. 2007 Nov;43(16):2388-95
17686627
Int J Cancer. 2004 Dec 10;112(5):865-71
15386383
Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):464-71
19190171
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1569-76
20501763
Int J Epidemiol. 2008 Oct;37(5):1080-94
18511490
Int J Cancer. 2004 Jun 20;110(3):429-34
15095310
J Photochem Photobiol B. 2007 Mar 1;86(3):234-9
17142054
J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9
17623801
J Natl Cancer Inst. 2005 Feb 2;97(3):161-3
15687354
Int J Cancer. 2007 Jun 1;120(11):2445-51
17311289
Am J Epidemiol. 2007 Jun 1;165(11):1255-64
17327216
Cancer Causes Control. 2007 Nov;18(9):1031-7
17653828
Cancer Causes Control. 2010 Aug;21(8):1265-75
20373010
Cancer Causes Control. 2006 Oct;17(8):1045-52
16933055
Int J Cancer. 2008 Jan 1;122(1):144-54
17708556
J Natl Cancer Inst. 1996 Mar 6;88(5):298-300
8614009
Int J Biometeorol. 2000 Nov;44(4):186-9
11131290
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):396-400
17337644