Random discrete competing events vs. dynamic bistable switches in cell proliferation in differentiation.
Several recent experiments related to fundamental aspects of cell behaviour, such as passing of the restriction point of cell cycle, which are generally interpreted in accordance with the dynamic paradigm implying the use of differential equations operating with the concentrations of cellular components and rate constants of their interactions, are shown in the present paper to be consistent with a simple model based on discrete competing stochastic events interpreted as assembly of alternative complexes of transcription factors at gene promoters. The model conforms to the transition probability model of cell cycle and to the stochastic approaches to cell differentiation and integrates them with the restriction point concept.
Golubev
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Research Institute for Experimental Medicine, Saint-Petersburg, Russia. lxglbv@rambler.ru
D000465:Algorithms; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D019927:Cyclin E / Q000502:physiology; D050684:E2F Transcription Factors / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000502:physiology; D011336:Probability; D011401:Promoter Regions, Genetic / Q000502:physiology; D013269:Stochastic Processes; D014157:Transcription Factors / Q000502:physiology
D019927:Cyclin E; D050684:E2F Transcription Factors; D046912:Multiprotein Complexes; D014157:Transcription Factors