title: Long-term outcomes of dismembered pyeloplasty for midline-crossing giant hydronephrosis caused by ureteropelvic junction obstruction in children.
abstract: OBJECTIVE
  To assess the long-term surgical outcomes of dismembered pyeloplasty for congenital midline-crossing giant hydronephrosis (GH) caused by ureteropelvic junction obstruction (UPJO).
  
  
  METHODS
  From June 1986 to September 2005, 167 unilateral UPJO pediatric patients who underwent dismembered pyeloplasty performed by a single surgeon were retrospectively analyzed. The patients were followed up for more than 5 years. Differential renal function (DRF) assessed by DTPA renal scan more than 3 years postoperatively was compared between GH and non-GH children. Improvement in renal parenchymal thickness (RPT) on ultrasonography at 5 years postsurgery was also compared. In GH children, surgical outcomes were compared based on the age at operation and whether preoperative nephrostomy was performed.
  
  
  RESULTS
  DRF measured more than 3 years postoperatively was 33 ± 14% versus 48 ± 12% (P < .05), and the improvement of RPT was 4 ± 2 mm (181%) versus 5 ± 4 mm (168%) in GH (n = 25) and non-GH (n = 142) children, respectively (P = .305). GH patients who underwent pyeloplasty before 12 months of age (n = 13) experienced more improvement in RPT (192% vs 102%) compared with GH patients who underwent surgery after 12 months of age (n = 12) (P < .05). The surgical outcomes for RPT improvement or long-term DRF were not different based on whether preoperative nephrostomy was performed. No children developed hypertension or elevated serum creatinine.
  
  
  CONCLUSIONS
  Long-term surgical outcomes after dismembered pyeloplasty for GH were satisfactory. In children with GH caused by UPJO, early relief of obstruction allows comparable nephron sparing.
authors.affiliation: Department of Urology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
authors.forename: Minki
authors.initials: M
authors.lastname: Baek
authors.forename: Kwanjin
authors.initials: K
authors.lastname: Park
authors.forename: Hwang
authors.initials: H
authors.lastname: Choi
mesh_terms: D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology / Q000601:surgery*; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D007677:Kidney Function Tests; D007682:Kidney Pelvis / Q000002:abnormalities / Q000473:pathology / Q000601:surgery*; D008297:Male; D009403:Nephrostomy, Percutaneous; D011877:Radionuclide Imaging; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014513:Ureter / Q000002:abnormalities / Q000473:pathology / Q000601:surgery; D014517:Ureteral Obstruction / Q000150:complications* / Q000601:surgery; D013520:Urologic Surgical Procedures / Q000379:methods*
chemical_list: D003404:Creatinine