Ovarian reserve in young women with low birth weight and normal puberty: a pilot case-control study.
OBJECTIVE
Studies indicate that women born small for gestational age (SGA) have impaired ovarian function. The origin of this ovarian dysfunction is still debatable. The aim of this study was to compare ovarian ageing between girls born appropriate for gestational age (AGA) and SGA. Therefore, we measured Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), E2, Anti-Müllerian hormone (AMH) levels and the pituitary response to endogenous Gonadotropin-releasing hormone (GnRH) in adolescent girls born SGA and AGA.


METHODS
A case-controlled pilot study consisting of seven SGA women (birth weight < 10th percentile AGA) and 13 AGA women with regular menstrual cycles, age 19.9 ± 0.42). Early follicular FSH, LH, Oestradiol (E2) and AMH levels were measured. After baseline samples, 100 μg GnRH was administered intravenously and at 30, 60 and 90 min blood samples were taken to measure gonadotropin levels and to compute the response to endogenous GnRH.


RESULTS
Mean follicular phase LH, FSH, E2 and AMH levels did not significantly differ between young women born SGA and AGA. Furthermore, the response to endogenous GnRH showed no significant differences either.


CONCLUSIONS
We concluded against extension of this pilot study. Based on our observations it seems unlikely that limited ovarian reserve is a predominated problem in adolescent SGA.
Sadrzadeh-Broer
Sheda
S
Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, VU University medical centre (VUmc), Amsterdam, The Netherlands.
Kuijper
Esther A M
EA
Van Weissenbruch
Mirjam M
MM
Lambalk
Cornelis B
CB
D000293:Adolescent; D000375:Aging / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001724:Birth Weight; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000502:physiology*; D010865:Pilot Projects; D010902:Pituitary Gland / Q000502:physiology; D011627:Puberty; D055815:Young Adult
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone