title: Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation.
abstract: In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies.
authors.affiliation: Institut des Biomolécules Max Mousseron UMR 5247 CNRS-Universités Montpellier I et II, Faculté de Pharmacie, 15 Av Ch Flahault, 34093 Montpellier cedex 5, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Berger
authors.forename: Sharon
authors.initials: S
authors.lastname: Wein
authors.forename: Jean-Frederic
authors.initials: JF
authors.lastname: Duckert
authors.forename: Marjorie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Siham
authors.initials: S
authors.lastname: El Fangour
authors.forename: Roger
authors.initials: R
authors.lastname: Escale
authors.forename: Thierry
authors.initials: T
authors.lastname: Durand
authors.forename: Henri
authors.initials: H
authors.lastname: Vial
authors.forename: Yen
authors.initials: Y
authors.lastname: Vo-Hoang
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001550:Benzamidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D001550:Benzamidines