title: [Cutaneo-viscero-hemolytic loxoscelism with acute renal failure].
abstract: The Loxoscelism is caused by the bite of spider Loxosceles laeta gender, of worldwide distribution. The poisoning can cause lesions dermonecrotic and less frequently a systemic illness that can be fatal. The mechanism of venom action is multifactorial. The characteristic dermonecrotic lesion results from the direct effects of the venom on the celular and basal membrane components, as well as the extracelular matrix. The initial interaction between the poison and tissues, causes complement activation, migration of polymorphic neutrophils, liberation of proteolytic enzymes, cytoquines, aggregation platelet, and blood flow alterations that result in edema and ischemia, with development of necrosis. There is no a definitive treatment for loxoscelism. However, the value of specific antivenom, to decrease lesion size and limit systemic illness even when such administration is delayed. We present a case of cutaneous-visceral loxoscelismo with unfavorable evolution.
authors.affiliation: "Servicio de Nefrología y Medio Internol, HNC-UNC".
authors.forename: Flavia V
authors.initials: FV
authors.lastname: Alfaro
authors.forename: Beatriz
authors.initials: B
authors.lastname: Dotto
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sesin
authors.forename: Viviana
authors.initials: V
authors.lastname: Prettini
authors.forename: Jorge
authors.initials: J
authors.lastname: Sesin
authors.forename: Enrique
authors.initials: E
authors.lastname: Aliciardi
authors.forename: Juan C
authors.initials: JC
authors.lastname: Vergottini
authors.forename: Mauricio
authors.initials: M
authors.lastname: Gonzalez
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000369:Aged, 80 and over; D000818:Animals; D000997:Antivenins / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D001098:Spider Bites / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013112:Spiders
chemical_list: D000997:Antivenins