Healthcare associated infection: novel strategies and antimicrobial implants to prevent surgical site infection.
This report is based on a Hygienist Panel Meeting held at St Anne's Manor, Wokingham on 24-25 June 2009. The panel agreed that greater use should be made of antiseptics to reduce reliance on antibiotics with their associated risk of antibiotic resistance. When choosing an antiseptic for clinical use, the Biocompatibility Index, which considers both the microbiocidal activity and any cytotoxic effects of an antiseptic agent, was considered to be a useful tool. The need for longer and more proactive post-discharge surveillance of surgical patients was also agreed to be a priority, especially given the current growth of day-case surgery. The introduction of surgical safety checklists, such as the World Health Organization's Safe Surgery Saves Lives initiative, is a useful contribution to improving safety and prevention of SSIs and should be used universally. Considering sutures as 'implants', with a hard or non-shedding surface to which micro-organisms can form biofilm and cause surgical site infections, was felt to be a useful concept.
Leaper
David
D
Wound Healing Research Unit, Cardiff University, Cardiff, UK. profdavidleaper@doctors.org.uk
McBain
Andrew J
AJ
Kramer
Axel
A
Assadian
Ojan
O
Sanchez
Jose Luis Alfonso
JL
Lumio
Jukka
J
Kiernan
Martin
M
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis / Q000379:methods; D000985:Antisepsis / Q000379:methods; D001422:Bacterial Adhesion; D018441:Biofilms; D006801:Humans; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013537:Sutures
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local
J Wound Care. 2008 Jan;17(1):24-7
18210953
Acta Chir Scand. 1977;143(2):71-3
899592
N Engl J Med. 2004 Apr 1;350(14):1422-9
15070792
J Wound Care. 2006 Mar;15(3):104-8
16550663
Surg Infect (Larchmt). 2007 Apr;8(2):209-14
17437366
Am J Surg. 1984 Feb;147(2):197-204
6364858
Antimicrob Agents Chemother. 2000 Jul;44(7):1818-24
10858336
N Engl J Med. 2009 Jan 29;360(5):491-9
19144931
Surg Infect (Larchmt). 2004 Fall;5(3):281-8
15684799
N Engl J Med. 2000 Jan 20;342(3):161-7
10639541
Surg Infect (Larchmt). 2002;3 Suppl 1:S55-63
12573040
AANA J. 1999 Apr;67(2):155-63
10488289
Surg Infect (Larchmt). 2002;3 Suppl 1:S79-87
12573042
Surg Infect (Larchmt). 2008 Aug;9(4):451-7
18687027
Prog Surg. 1970;8:14-37
4984024
Ann Thorac Surg. 2007 Jul;84(1):232-6
17588420
Arch Surg. 1983 Mar;118(3):322-7
6218796
J Neurosurg Pediatr. 2008 Aug;2(2):111-7
18671615
Lancet. 1986 May 24;1(8491):1208-9
2871441
J Am Coll Surg. 2006 Oct;203(4):481-9
17000391
Graefes Arch Clin Exp Ophthalmol. 2005 Sep;243(9):951-4
15834610
Cir Pediatr. 2008 Oct;21(4):199-202
18998368
Surg Clin North Am. 1980 Feb;60(1):27-40
7361226
J Immunol. 2005 Dec 1;175(11):7512-8
16301659
Acta Chir Scand. 1979;145(7):431-4
539325
J Antimicrob Chemother. 2008 Jun;61(6):1281-7
18364400
Surg Infect (Larchmt). 2007 Jun;8(3):359-65
17635059
Am J Epidemiol. 1985 Feb;121(2):206-15
4014116
Antimicrob Agents Chemother. 2004 Aug;48(8):2973-9
15273108
Wound Repair Regen. 2007 Jul-Aug;15(4):474-81
17650090
Ann Surg. 1973 Jun;177(6):679-88
4267743
Antibiot Khimioter. 1994 May;39(5):45-8
7857161
Skin Pharmacol Physiol. 2004 May-Jun;17(3):141-6
15087593
Surgery. 2009 Mar;145(3):330-4
19231586
Surg Infect (Larchmt). 2002;3 Suppl 1:S45-53
12573039
J Plast Reconstr Aesthet Surg. 2009 Jun;62(6):771-3
18450530
Skin Pharmacol Physiol. 2007;20(6):292-6
17717425
J Clin Microbiol. 2007 Nov;45(11):3833-6
17913935
Surg Gynecol Obstet. 1962 Sep;115:266-75
14449384
Ann Surg. 1981 Jul;194(1):35-41
7018429
Arch Intern Med. 2004 Apr 26;164(8):842-50
15111369
J Dtsch Dermatol Ges. 2009 Sep;7(9):759-65
19228295
Anesthesiology. 2004 Feb;100(2):274-80
14739800
Klin Khir. 1993;(1):49-51
10912033
Surg Infect (Larchmt). 2005 Fall;6(3):313-21
16201941
J Chemother. 2001 Nov;13 Spec No 1(1):96-101
11936388