Evaluation of predictive models for stable solid solution formation.
The objective of this study was to evaluate predictive models for stable solid solution formation and to find a quick and successful approach for miscibility screenings. The results show that the interpretation of the chemical structure and the crystallinity by X-ray powder diffraction measurements as well as the determination of melting point depressions and melting enthalpies are beneficial tools to predict the miscibility of drugs and carriers. A combined approach of prediction tools is highly appropriate, as no single technique may yield all the required information. Nevertheless, the evaluation of the melting behavior via differential scanning calorimetry has the highest impact.
Albers
Jessica
J
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany.
Matthée
Karin
K
Knop
Klaus
K
Kleinebudde
Peter
P
D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D044367:Phase Transition; D012995:Solubility; D012996:Solutions / Q000737:chemistry; D013816:Thermodynamics; D044366:Transition Temperature
D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012996:Solutions