title: Pediatric dosimetry for intrapleural lung injections of (32)P chromic phosphate.
abstract: Intracavitary injections of (32)P chromic phosphate are used in the therapy of pleuropulmonary blastoma and pulmonary sarcomas in children. The lung dose, however, has never been calculated despite the potential risk of lung toxicity from treatment. In this work the dosimetry has been calculated in target tissue and lung for pediatric phantoms. Pleural cavities were modeled in the Monte Carlo code MCNP within the pediatric MIRD phantoms. Both the depth-dose curves in the pleural lining and into the lung as well as 3D dose distributions were calculated for either homogeneous or inhomogeneous (32)P activity distributions. Dose-volume histograms for the lung tissue and isodose graphs were generated. The results for the 2D depth-dose curve to the pleural lining and tumor around the pleural cavity correspond well with the point kernel model-based recommendations. With a 2 mm thick pleural lining, one-third of the lung parenchyma volume gets a dose more than 30 Gy (V(30)) for 340 MBq (32)P in a 10 year old. This is close to lung tolerance. Younger children will receive a larger dose to the lung when the lung density remains equal to the adult value; the V(30) relative lung volume for a 5 year old is 35% at an activity of 256 MBq and for a 1 year old 165 MBq yields a V(30) of 43%. At higher densities of the lung tissue V(30) stays below 32%. All activities yield a therapeutic dose of at least 225 Gy in the pleural lining. With a more normal pleural lining thickness (0.5 mm instead of 2 mm) the injected activities will have to be reduced by a factor 5 to obtain tolerable lung doses in pediatric patients. Previous dosimetry recommendations for the adult apply well down to lung surface areas of 400 cm(2). Monte Carlo dosimetry quantitates the three-dimensional dose distribution, providing a better insight into the maximum tolerable activity for this therapy.
authors.affiliation: Erasmus MC, Department of Nuclear Medicine, Rotterdam, The Netherlands. M.Konijnenberg@erasmusmc.nl
authors.forename: Mark W
authors.initials: MW
authors.lastname: Konijnenberg
authors.forename: Arthur
authors.initials: A
authors.lastname: Olch
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D017608:Chromium Compounds / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007267:Injections; D008168:Lung / Q000473:pathology / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008954:Models, Biological; D009010:Monte Carlo Method; D058958:Organs at Risk / Q000473:pathology / Q000528:radiation effects*; D019047:Phantoms, Imaging; D010710:Phosphates / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D010994:Pleura / Q000473:pathology / Q000528:radiation effects; D035422:Pleural Cavity / Q000473:pathology / Q000528:radiation effects*; D018202:Pulmonary Blastoma / Q000473:pathology / Q000532:radiotherapy; D011829:Radiation Dosage; D011874:Radiometry; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy
chemical_list: D017608:Chromium Compounds; D010710:Phosphates; C509370:chromic phosphate, 32P-labeled