title: A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
abstract: A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2. This endogenous CPA regulates PPARgamma functions required for adipogenesis, glucose homeostasis, and vascular wall biology.
authors.affiliation: Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Oishi-Tanaka
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Glass