title: Reaction time variability in HIV-positive individuals.
abstract: Progression of HIV/AIDS is frequently associated with frontal/subcortical dysfunction and mean reaction time (RT) slowing. Beyond group means, within-subject variability of RT has been found to be particularly sensitive to frontal/subcortical dysfunction in other populations. However, the possible relevance of RT variability to HIV/AIDS patients remains unknown. This study evaluated the relationships between RT variability and indicators such as neurocognitive, behavioral, and immunological status. A total of 46 HIV-positive adults on antiretroviral medication regimens were included in this study. Overall performance of this sample was poorer than normative means on measures of RT latency, RT variability, and traditional neurocognitive domains. Results demonstrated that the measures of RT variability were associated with global cognition, medication adherence rates, and peak immunological dysfunction, above and beyond the effects of RT latency. These preliminary findings suggest that measures of RT variability may provide enhanced sensitivity to neurocognitive disease burden in HIV/AIDS relative to more traditional measures of mean RT or cognitive function.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, USA. ettenhofer@gmail.com
authors.forename: Mark L
authors.initials: ML
authors.lastname: Ettenhofer
authors.forename: Jessica
authors.initials: J
authors.lastname: Foley
authors.forename: Nina
authors.initials: N
authors.lastname: Behdin
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Levine
authors.forename: Steven A
authors.initials: SA
authors.lastname: Castellon
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hinkin
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D003071:Cognition / Q000502:physiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006679:HIV Seropositivity / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*
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