The role of the mTOR pathway in regulating food intake.
mTOR is a principal effector of nutrient action, integrating nutritional inputs from glucose, amino acids and fatty acids, as well as growth factor and hormonal signals. The mTOR signaling pathway plays a vital role in regulating cell growth and proliferation, and has been studied extensively in a variety of metabolic and cancer models. However, only recently has the mTOR signaling pathway become implicated in the regulation of food intake. This review focuses on recent studies describing the role of hypothalamic and gastric mTOR signaling in suppressing food intake, and discusses the potential mechanisms through which this regulation occurs.
Wiczer
Brian M
BM
University of Cincinnati, Department of Cancer and Cell Biology, Metabolic Diseases Institute, College of Medicine, 2180 East Galbraith Road, Building D/Room 284, Cincinnati, OH 45237, USA. wiczerbn@ucmail.uc.edu
Thomas
George
G
D000818:Animals; D000855:Anorexia / Q000378:metabolism; D001069:Appetite Regulation / Q000502:physiology*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D009752:Nutritional Status / Q000502:physiology*; D009765:Obesity / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism* / Q000502:physiology*
D058570:TOR Serine-Threonine Kinases