title: Treatment of recurrent vulvar Paget disease with imiquimod cream: a case report and review of the literature.
abstract: BACKGROUND
  Extra-mammary Paget disease is one of the rare neoplastic conditions of the skin. The most common site of involvement is the vulva and presents itself with erythematous plaques. Surgery is the most important treatment option. In the recent years, there are publications of the topical use of imiquimod cream in extra-mammary cutaneous Paget disease. We report the case of a woman with recurrent vulvar Paget disease, who underwent successful treatment with imiquimod cream. We also review the reports of other patients with vulvar Paget disease who were treated with topical imiquimod cream.
  
  
  METHODS
  A 65-year-old woman presented to the Oncology Outpatient Clinic with an itchy lesion in her vulva for 2 years. In the gynecologic examination, a hyperkeratotic erythematous lesion was found starting from the right labium to involve clitoris, with a size of 4 × 3 cm. Pathology result was reported as Paget disease. She was operated and wide vulvar excision was performed with a safety margin of 2 cm. Then recurrence two times occurred. Because she refused surgery, imiquimod cream 5% was applied for treatment.
  
  
  CONCLUSIONS
  Imiquimod cream is an effective and safe therapeutic agent for both primary and recurring vulvar Paget disease.
authors.affiliation: Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad. Binnaz Sok. No:1/5 Kavaklidere, Ankara, Turkey. esratonguc@yahoo.com
authors.forename: Esra
authors.initials: E
authors.lastname: Tonguc
authors.forename: Tayfun
authors.initials: T
authors.lastname: Güngor
authors.forename: Turgut
authors.initials: T
authors.lastname: Var
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozat
authors.forename: Izzet
authors.initials: I
authors.lastname: Sahin
authors.forename: Levent
authors.initials: L
authors.lastname: Sirvan
mesh_terms: D000368:Aged; D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001623:Betamethasone / Q000627:therapeutic use; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000077271:Imiquimod; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D004643:Emollients; D001623:Betamethasone; D000077271:Imiquimod
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