Effect of the statin therapy on biochemical laboratory tests--a chemometrics study.
Statins are the first-line choice for lowering total and LDL cholesterol levels and very important medicaments for reducing the risk of coronary artery disease. The aim of this study is therefore assessment of the results of biochemical tests characterizing the condition of 172 patients before and after administration of statins. For this purpose, several chemometric tools, namely principal component analysis, cluster analysis, discriminant analysis, logistic regression, KNN classification, ROC analysis, descriptive statistics and ANOVA were used. Mutual relations of 11 biochemical laboratory tests, the patient's age and gender were investigated in detail. Achieved results enable to evaluate the extent of the statin treatment in each individual case. They may also help in monitoring the dynamic progression of the disease.
Durceková
Tatiana
T
Department of Chemistry, University of SS Cyril and Methodius, J. Herdu 2, Trnava, SK-917 01, Slovak Republic. tatjana@centrum.sk
Mocák
Ján
J
Boronová
Katarína
K
Balla
Ján
J
D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000175:diagnosis; D002623:Chemistry Techniques, Analytical; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry*; D006949:Hyperlipidemias / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D025341:Principal Component Analysis; D012372:ROC Curve; D012044:Regression Analysis; D012306:Risk
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008074:Lipoproteins