Deep brain stimulation of the lateral cerebellar nucleus produces frequency-specific alterations in motor evoked potentials in the rat in vivo.
The cerebral cortex is tightly and reciprocally linked to the cerebellum and the ascending dentato-thalalmo-cortical pathway influences widespread cortical regions. Using a rodent model of middle cerebral artery stroke, we showed previously that chronic, 20 Hz stimulation of the contralateral lateral cerebellar nucleus (LCN) improved motor recovery, while 50 Hz stimulation did not. Using motor evoked potentials (MEP) elicited by intracortical microstimulation, we now show the effect of LCN stimulation on motor cortex excitability as a function of pulse frequency in propofol-anesthetized rats. MEPs were recorded serially, at 15-s intervals, with cerebellar stimulation delivered in 10-min blocks at rates of 20, 30, 40, 50 or 100 Hz. Stimulation at 20, 30, 40 or 50 Hz enhanced the average MEP response across the block, with the maximal overall increase observed during 30 Hz stimulation. However, the effect varied as a function of both repeated trials within the block and LCN stimulation frequency, such that 40 Hz and 50 Hz stimulation showed a reduced effect over time. Stimulation at 100 Hz produced a transient increase in MEP amplitude in some animals; however the overall effect across the block was a trend towards reduced cortical excitability. These results suggest that direct stimulation of the LCN can yield frequency-dependent changes in cortical excitability and may provide a therapeutic approach to modulating cortical activity for the treatment of strokes or other focal cortical lesions, movement disorders and epilepsy.
Baker
Kenneth B
KB
Department of Neuroscience (NC-30), Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.
Schuster
Daniel
D
Cooperrider
Jessica
J
Machado
Andre G
AG
D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology*; D003265:Contingent Negative Variation / Q000502:physiology; D046690:Deep Brain Stimulation; D004566:Electrodes; D004576:Electromyography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000502:physiology*; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
Curr Biol. 2004 Nov 9;14(21):1907-15
15530391
Brain Res. 2009 Jul 14;1280:107-16
19445910
Exp Brain Res. 1976 Mar 15;24(5):495-507
1253863
Stroke. 2006 Jun;37(6):1471-6
16675743
J Neurophysiol. 2003 Jan;89(1):634-9
12522208
Top Stroke Rehabil. 2008 Mar-Apr;15(2):160-72
18430685
J Neurosurg. 2008 Apr;108(4):707-14
18377250
J Neurophysiol. 2003 Jun;89(6):3205-14
12783955
Stroke. 2009 May;40(5):1926-31
19359643
J Neurol Neurosurg Psychiatry. 1994 Jan;57(1):108-10
8301289
Brain. 1950 Jun;73(2):125-40
14791783
Brain Stimul. 2008 Jul;1(3):151-63
20633382
Nat Neurosci. 1998 May;1(1):64-8
10195111
Neurol Res. 2003 Dec;25(8):780-8
14669519
Neurosci Lett. 2004 May 6;361(1-3):106-10
15135905
J Neurophysiol. 2008 Sep;100(3):1498-512
18596180
Brain Res. 1975 May 2;88(2):233-41
1148824
Brain. 1999 Oct;122 ( Pt 10):1919-31
10506093
Exp Brain Res. 1982;47(3):365-80
6889975
Neurosurgery. 1987 Jan;20(1):193-5
3808262
J Neurosci Res. 2006 Feb 1;83(2):177-80
16385580
J Neurophysiol. 2000 Jul;84(1):585-90
10899231
Trans Am Neurol Assoc. 1973;98:192-6
4206369
J Comp Neurol. 1978 Apr 1;178(3):495-517
19626723
Acta Neurochir (Wien). 1995;136(1-2):75-81
8748831
Neurorehabil Neural Repair. 2007 Jan-Feb;21(1):14-24
17172550
Neuroscientist. 2003 Feb;9(1):64-75
12580341
Brain Res. 1971 Mar 19;27(1):97-109
4251989
Neurol Res. 2003 Dec;25(8):801-10
14669522
Physiol Rev. 1974 Oct;54(4):957-1006
4370744
Neurosurgery. 1987 Jan;20(1):195-7
3808263
Neuron. 2007 Oct 25;56(2):209-25
17964241
Lancet Neurol. 2003 Aug;2(8):493-502
12878437
Exp Brain Res. 1998 Mar;119(2):179-90
9535568
Neurosci Lett. 1981 Mar 10;22(2):137-44
7231805
Brain Res. 1983 May;286(3):267-97
6189562
Cogn Behav Neurol. 2006 Mar;19(1):41-7
16633018
J Comp Neurol. 1981 Apr 1;197(2):217-36
7276233
Brain Res. 1975 Nov 7;98(1):73-92
1175060
Clin Neurol Neurosurg. 2004 Sep;106(4):318-29
15297008
Appl Neurophysiol. 1983;46(1-4):57-61
6608318
Neuroscience. 2002;111(4):863-70
12031409
Stroke. 2006 Aug;37(8):2115-22
16809569
J Neurol. 2001 Apr;248(4):315-21
11374097
Exp Brain Res. 2004 Dec;159(4):418-24
15558250
J Neural Transm (Vienna). 2009 Apr;116(4):423-9
19238517
J Physiol. 1979 Dec;297(0):559-80
119847
Stroke. 2000 Jun;31(6):1210-6
10835434
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):769-74
6381652
Brain. 2005 Mar;128(Pt 3):490-9
15634731
Brain. 1979 Mar;102(1):127-46
106923
Stroke. 2006 Nov;37(11):2850-3
17008618