title: Role of physical activity and diet in incidence of hypertension: a population-based study in Portuguese adults.
abstract: OBJECTIVE
  To evaluate longitudinally the role of physical activity (PA) (type and intensity) and diet (measured using DASH score, nutrients and food intake) in hypertension incidence.
  
  
  METHODS
  As part of the EPIPorto study, 549 participants (≥40 years), resident in Porto, Portugal, at risk of developing hypertension, were evaluated. Blood pressure (BP) measurements were obtained twice (1999-2003 and 2005-2008), with a median interval of 3.8 years. Hypertension was defined as systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg, and/or if the subjects were under anti-hypertensive therapy. Validated questionnaires were used to assess usual PA and dietary intake during the previous year. Poisson regression was used to calculate the incident rate ratios (IRRs) and respective 95% confidence intervals (95% CIs).
  
  
  RESULTS
  In our population, the crude incidence rate (95% confidence interval (CI)) per 100 person-years of hypertension was 6.23 (5.26-7.20). After adjustment for several confounders, an inverse, though not significant, association was found across increasing tertiles of leisure-time PA and IRR (95% CI): 1 (reference); 0.77 (0.51-1.16); and 0.74 (0.48-1.11). No significant associations between the DASH score and hypertension incidence were observed. However, potassium intake (mg/1000 kcal) was shown to be inversely associated with hypertension development (upper tertile: >1863.0 for women and >1657.2 for men) vs first tertile (IRR=0.65 (0.44-0.96), P for trend=0.025). Additionally, in multivariate analysis, a significantly inverse association between the consumption of fruits/vegetables/pulses and hypertension incidence was found (upper vs first tertile: IRR=0.61 (0.40-0.93), P for trend=0.024).
  
  
  CONCLUSIONS
  In Portuguese adults, after adjustment for several confounders, the development of hypertension was inversely associated with potassium and fruits/vegetables/pulses intake. A dose-response is inherent to these inverse associations.
authors.affiliation: Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Camões
authors.forename: A
authors.initials: A
authors.lastname: Oliveira
authors.forename: M
authors.initials: M
authors.lastname: Pereira
authors.forename: M
authors.initials: M
authors.lastname: Severo
authors.forename: C
authors.initials: C
authors.lastname: Lopes
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018672:Community Health Planning; D004032:Diet; D004435:Eating; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D005638:Fruit / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D016012:Poisson Distribution; D011174:Portugal / Q000453:epidemiology; D011188:Potassium; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D014675:Vegetables / Q000378:metabolism
chemical_list: D011188:Potassium