Satellite signaling at synapses.
Neural function requires effective communication between neurons and their targets at synapses. Thus, proper formation, growth and plasticity of synapses are critical to behavior. A retrograde (muscle to neuron) BMP signal is required to promote synaptic growth, homeostasis and stability at Drosophila neuromuscular junctions (NMJs).(1-4) We recently demonstrated that this signal constitutes an instructive signal that sculpts synaptic growth in a graded manner and uncovered a presynaptic endocytic mechanism that modulates BMP signaling levels. In the absence of this regulation, excessive BMP signaling results in overgrown NMJs with a proliferation of ectopic boutons.(5).
O'Connor-Giles
Kate M
KM
Laboratory of Genetics, University of Wisconsin - Madison, Madison, Wisconsin 53706, USA. oconnorgiles@wisc.edu
Ganetzky
Barry
B
D000818:Animals; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology; D008959:Models, Neurological; D009132:Muscles / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology; D009474:Neurons / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C483010:nwk protein, Drosophila
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