Infectious diseases not immune to genome-wide association.
Two genome-wide association studies for meningococcal disease and tuberculosis identify new loci associated with susceptibility to these infectious diseases. They highlight a role for the acquired and innate immune systems in host control of several human pathogens and demonstrate that denser genotyping platforms and population-specific reference panels are necessary for genetic studies in African populations.
de Bakker
Paul I W
PI
Telenti
Amalio
A
D000349:Africa; D003141:Communicable Diseases / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population / Q000639:trends; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data / Q000639:trends; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D055552:Infectious Disease Medicine / Q000379:methods / Q000639:trends*
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