Study of intra-abdominal fat distribution in sigmoid colon cancer in Japanese patients by use of MDCT data.
To assess the relationship between intra-abdominal fat and sigmoid colon cancer, we investigated the intra-abdominal fat distribution in 172 examples of sigmoid colon cancer and 767 examples of various other pathologies by using data from multidetector-row computed tomography. One significant finding was that the intra-abdominal fat area in sigmoid colon cancer presents a small secondary peak in the pelvis on the profile of the intra-abdominal fat, which we called the pelvic sub-peak. The presence or absence of the pelvic sub-peak was determined based on the sub-peak ratio, which was calculated by dividing the maximum peak by the sub-peak value on the profile of the intra-abdominal fat area. The pelvic sub-peak was defined as having a sub-peak ratio >or=0.1. The pelvic sub-peak frequency was higher for all male patients than for female patients. The frequency of the pelvic sub-peak in sigmoid colon cancer was 77.5% (79/102) for men and 50.0% (35/70) for women. Among both men and women, frequencies of the pelvic sub-peak were significantly higher in patients with sigmoid colon cancer than in non-tumor cases (P < 0.001). Furthermore, the frequency of the pelvic sub-peak was almost the same in sigmoid colon cancer as in rectal cancer. No causal relationship between sigmoid colon cancer and a pelvic sub-peak could be confirmed in the present study; however, patients with sigmoid colon cancer tended to exhibit a unique pattern of fat accumulation.
Ogura
Toshihiro
T
School of Radiological Technology, Gunma Prefectural College of Health Sciences, Maebashi, Gunma, Japan. togura@gchs.ac.jp
Tachikawa
Tomohiro
T
Nishimura
Yoshiko
Y
Suda
Satoshi
S
Shimomura
Younosuke
Y
Oya
Masatoshi
M
Kono
Atsushi
A
D050153:Abdominal Fat / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000000981:diagnostic imaging; D012811:Sigmoid Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
Metabolism. 2001 Apr;50(4):425-35
11288037
Horm Metab Res. 2002 Nov-Dec;34(11-12):616-21
12660870
Radiology. 1999 Apr;211(1):283-6
10189485
Int J Obes. 1983;7(5):437-45
6642855
Int J Obes (Lond). 2008 Feb;32(2):304-14
17878894
Diabetes Metab Rev. 1997 Mar;13(1):3-13
9134345
Am J Clin Nutr. 1988 Dec;48(6):1351-61
3202084
Int J Obes Relat Metab Disord. 1994 Apr;18(4):219-34
8044196
Atherosclerosis. 1994 Jun;107(2):239-46
7980698
Metabolism. 1987 Jan;36(1):54-9
3796297
Circ J. 2002 Nov;66(11):987-92
12419927
Hypertension. 1990 Nov;16(5):484-90
2228147
J Nutr. 2002 Nov;132(11 Suppl):3451S-3455S
12421869
J Atheroscler Thromb. 2005;12(6):301
16394611
Nihon Hoshasen Gijutsu Gakkai Zasshi. 2005 Jun 20;61(6):840-6
15995615
Arch Intern Med. 1989 Jul;149(7):1514-20
2662932