title: Intensive insulin therapy versus conventional insulin therapy for critically ill trauma patients admitted to ICU.
abstract: OBJECTIVE
  The objective of our study was to evaluate the beneficial effect of IIT in reducing mortality and morbidity in critically ill trauma patients admitted to ICU.
  
  
  METHODS
  Nested cohort study within a Randomized Controlled Trial. All trauma patients with GCS < or = 9 included in the original trial were included in this study. Primary outcome was ICU mortality.
  
  
  RESULTS
  There was no difference in ICU mortality between IIT and CIT groups (6.5% vs. 5.5%, p = 0.67). After adjustment for baseline characteristics, IIT therapy was also not associated with mortality (Adjusted Hazard Ratio 1.33, 95% CI 0.35-5.05). IIT therapy was associated with a significant increase in the incidence of hypoglycemia as compared to CIT, at least one hypoglycemia episode occurred in 18.5% of patients in IIT and 1.3% in the CIT group (P < 0.0001).
  
  
  CONCLUSIONS
  IIT was not associated with survival improvement in trauma patients admitted to ICU and was associated with increased incidence of hypoglycemia.
authors.affiliation: Department of Intensive Care Medicine, College of Medicine, King Abdulaziz Medical City and King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
authors.forename: Abdulaziz S
authors.initials: AS
authors.lastname: Aldawood
authors.forename: Hani M
authors.initials: HM
authors.lastname: Tamim
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Alsultan
authors.forename: Asgar H
authors.initials: AH
authors.lastname: Rishu
authors.forename: Yaseen M
authors.initials: YM
authors.lastname: Arabi
mesh_terms: D000328:Adult; D015331:Cohort Studies; D016638:Critical Illness; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology; D007328:Insulin / Q000008:administration & dosage*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D014947:Wounds and Injuries / Q000097:blood / Q000188:drug therapy* / Q000401:mortality
chemical_list: D007328:Insulin