title: Sleep and daily functioning during androgen deprivation therapy for prostate cancer.
abstract: A limited body of evidence suggests that sleep problems are common in prostate cancer patients undergoing androgen deprivation therapy, yet little is known about sleep characteristics and the effects of poor sleep on daily functioning in this population. This study assessed sleep in 60 prostate cancer patients taking androgen deprivation therapy with wrist actigraphy and daily diaries for 7 days. The Epworth Sleepiness Scale and the general version of the Functional Assessment of Cancer Therapy scale were also administered. On average, total sleep time was 5.9 (SD = 1.4) h, and sleep efficiency was 75% (SD = 12.0) as assessed by actigraphy. There was generally poor concordance between actigraphy and daily diary for most sleep metrics. Subjects reported awakening, on average, 2.7 times per night, most commonly for nocturia and hot flashes. Assessment of daily functioning showed that participants had mild daytime sleepiness, which was predicted by total sleep time (F(1,47) = 4.5, P= 0.04) General quality of life was not impaired. This study supports more research on the predictors of poor sleep in order to identify effective interventions.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. hanisch@mail.med.upenn.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Hanisch
authors.forename: N S
authors.initials: NS
authors.lastname: Gooneratne
authors.forename: K
authors.initials: K
authors.lastname: Soin
authors.forename: P R
authors.initials: PR
authors.lastname: Gehrman
authors.forename: D J
authors.initials: DJ
authors.lastname: Vaughn
authors.forename: J C
authors.initials: JC
authors.lastname: Coyne
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D019584:Hot Flashes / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011788:Quality of Life; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000139:chemically induced*; D011795:Surveys and Questionnaires
chemical_list: D000726:Androgen Antagonists
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