Taurine and the renal system.
Taurine participates in a number of different physiologic and biologic processes in the kidney, often reflected by urinary excretion patterns. The kidney is key to aspects of taurine body pool size and homeostasis. This review will examine the renal-taurine interactions relative to ion reabsorption; renal blood flow and renal vascular endothelial function; antioxidant properties, especially in the glomerulus; and the role of taurine in ischemia and reperfusion injury. In addition, taurine plays a role in the renal cell cycle and apoptosis, and functions as an osmolyte during the stress response. The role of the kidney in adaptation to variations in dietary taurine intake and the regulation of taurine body pool size are described. Finally, the protective function of taurine against several kidney diseases is reviewed.
Chesney
Russell W
RW
Department of Pediatrics, University of Tennessee Health Science Center, and the Children's Foundation Research Center at Le Bonheur Children's Medical Center, 50 N, Dunlap, Memphis, Tennessee 38103, USA. rchesney@uthsc.edu
Han
Xiaobin
X
Patters
Andrea B
AB
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D006801:Humans; D007477:Ions / Q000378:metabolism; D007668:Kidney / Q000098:blood supply / Q000378:metabolism*; D007674:Kidney Diseases / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000378:metabolism; D009994:Osmolar Concentration; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*
D007477:Ions; D013654:Taurine
Adv Exp Med Biol. 2009;643:135-44
19239144
In Vitro Cell Dev Biol Anim. 1995 Jul-Aug;31(7):483-6
8528493
Kidney Int. 2001 Aug;60(2):408-11
11473617
Adv Exp Med Biol. 2009;643:451-61
19239177
Nephrol Dial Transplant. 2002 Mar;17(3):528-9
11865115
Am J Physiol Renal Physiol. 2004 Dec;287(6):F1140-7
15315938
Adv Exp Med Biol. 2009;643:47-55
19239135
J Clin Invest. 1982 Sep;70(3):598-607
6286728
J Clin Invest. 1991 Aug;88(2):656-62
1864974
Adv Exp Med Biol. 2009;643:359-68
19239167
Kidney Int. 1995 Sep;48(3):761-70
7474662
J Biomed Sci. 2010 Aug 24;17 Suppl 1:S30
20804606
J Intern Med. 1989 Sep;226(3):189-94
2794849
Diabetes Metab Res Rev. 2001 Sep-Oct;17(5):330-46
11747139
J Pediatr. 2008 Jan;152(1):4-6
18154887
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8230-4
1518851
Proc Soc Exp Biol Med. 1982 Sep;170(4):493-501
7122479
J Biomed Sci. 2010 Aug 24;17 Suppl 1:S2
20804594
Adv Exp Med Biol. 2009;643:75-84
19239138
J Nutr. 1988 Oct;118(10):1169-76
3054019
Am J Hypertens. 2003 Aug;16(8):673-80
12878374
Kidney Int. 1983 Nov;24(5):588-94
6663980
J Am Soc Nephrol. 2009 Jun;20(6):1323-32
19423693
Can J Physiol Pharmacol. 2003 Sep;81(9):903-9
14614528
Adv Exp Med Biol. 2009;643:145-56
19239145
Adv Exp Med Biol. 2009;643:105-12
19239141
Adv Exp Med Biol. 1998;442:261-8
9635040
Biochem Biophys Res Commun. 1994 Feb 28;199(1):346-52
8123033
J Biol Chem. 2002 Oct 18;277(42):39266-73
12163498
Neurochem Res. 2004 Jan;29(1):27-63
14992263
J Nutr. 1989 Oct;119(10):1452-60
2585136
Antioxid Redox Signal. 2002 Jun;4(3):501-7
12215218
Biochem Pharmacol. 1978;27(23):2689-92
728224
Amino Acids. 2000;19(3-4):499-507
11140355
Am J Physiol. 1975 Aug;229(2):298-302
1163658
Adv Exp Med Biol. 2003;526:49-56
12908583
Pediatr Res. 1997 May;41(5):624-31
9128282
J Clin Invest. 1976 Jan;57(1):183-93
1245598
Adv Exp Med Biol. 2006;583:493-8
17153636
Physiol Rev. 2007 Oct;87(4):1441-74
17928589
Adv Exp Med Biol. 2009;643:463-72
19239178
Adv Exp Med Biol. 2006;583:481-92
17153635
Am J Clin Nutr. 2000 Jan;71(1):54-8
10617946
Kidney Int. 1994 Oct;46(4):1025-30
7861697
Diab Vasc Dis Res. 2010 Oct;7(4):300-10
20667936
FASEB J. 2005 Oct;19(12):1657-67
16195374
Am J Physiol. 1989 Apr;256(4 Pt 2):F646-55
2705536
Physiol Rev. 1992 Jan;72(1):101-63
1731369
Pflugers Arch. 1976 Dec 28;367(2):123-8
1034908
N Engl J Med. 1996 May 30;334(22):1448-60
8618585
J Am Soc Nephrol. 2007 Mar;18(3):760-70
17267745
Adv Exp Med Biol. 2009;643:123-33
19239143
Kidney Int. 1990 Aug;38(2):219-26
2402115
Am J Physiol. 1992 Jan;262(1 Pt 2):F117-23
1733287
Am J Physiol. 1993 Jul;265(1 Pt 2):F137-45
8342611
Pediatr Nephrol. 1993 Feb;7(1):35-40
8382504
Mol Pharmacol. 1992 Oct;42(4):563-9
1435737
Pediatr Res. 1988 Jan;23(1):35-9
3340441
Nephrol Dial Transplant. 2000 Aug;15(8):1175-82
10910441
Am J Physiol. 1995 Sep;269(3 Pt 2):F429-38
7573492
Adv Exp Med Biol. 1996;403:223-32
8915359
Kidney Int. 2002 May;61(5):1750-9
11967024
Kidney Int. 1997 Sep;52(3):748-54
9291196
Adv Exp Med Biol. 2006;583:49-57
17153588
Kidney Int. 2006 Jul;70(2):329-37
16760912
Acta Physiol (Oxf). 2006 May-Jun;187(1-2):61-73
16734743
Pediatr Res. 1981 Jan;15(1):10-13
7208162
Pediatr Nephrol. 1993 Oct;7(5):635-8
8251338
Biochim Biophys Acta. 1997 Apr 10;1351(3):296-304
9130593
Jpn Circ J. 1991 May;55(5):500-8
2062001
Adv Exp Med Biol. 2009;643:523-32
19239184
Am J Kidney Dis. 1986 Nov;8(5):368-79
3538860
Genomics. 1995 Jan 1;25(1):314-7
7774940
Am J Physiol. 1982 Jan;242(1):R64-9
7058931
J Am Soc Nephrol. 2001 May;12(5):900-908
11316848