Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis.
The present study aimed to investigate the presence of corpus callosum (CC) volume deficits in a population-based recent-onset psychosis (ROP) sample, and whether CC volume relates to interhemispheric communication deficits. For this purpose, we used voxel-based morphometry comparisons of magnetic resonance imaging data between ROP (n =122) and healthy control (n = 94) subjects. Subgroups (38 ROP and 39 controls) were investigated for correlations between CC volumes and performance on the Crossed Finger Localization Test (CFLT). Significant CC volume reductions in ROP subjects versus controls emerged after excluding substance misuse and non-right-handedness. CC reductions retained significance in the schizophrenia subgroup but not in affective psychoses subjects. There were significant positive correlations between CC volumes and CFLT scores in ROP subjects, specifically in subtasks involving interhemispheric communication. From these results, we can conclude that CC volume reductions are present in association with ROP. The relationship between such deficits and CFLT performance suggests that interhemispheric communication impairments are directly linked to CC abnormalities in ROP.
Chaim
Tiffany M
TM
Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Schaufelberger
Maristela S
MS
Ferreira
Luiz K
LK
Duran
Fábio L S
FL
Ayres
Adriana M
AM
Scazufca
Marcia
M
Menezes
Paulo R
PR
Amaro
Edson
E
Leite
Claudia C
CC
Murray
Robin M
RM
McGuire
Philip K
PK
Rushe
Teresa M
TM
Busatto
Geraldo F
GF
D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders / Q000209:etiology*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000150:complications* / Q000473:pathology*; D013223:Statistics as Topic; D014163:Transfer, Psychology / Q000502:physiology*; D055815:Young Adult