Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity.
Optimal fat mass is necessary for normal gonadotropin levels in adults, and both undernutrition and overnutrition suppress gonadotropins: thus, the gonadotropin response to relative adipose mass is biphasic. Adult obesity is associated with blunted luteinizing hormone (LH) pulse amplitude that is partially attributable to increased LH clearance rate. Testosterone appears to have a biphasic effect on gonadotropin production in females. Moderate elevations of testosterone appear to stimulate LH production at both the hypothalamic and pituitary level, while very high levels of testosterone suppress LH. Thus, obesity per se appears to suppress gonadotropin production, and moderate hyperandrogenemia in women appears to stimulate LH. The ordinary hypergonadotropic hyperandrogenism of obese women appears to be an exception to this model because it is usually due to polycystic ovary syndrome (PCOS), a condition in which intrinsic functional ovarian hyperandrogenism and excess adiposity share a common origin that involves insulin-resistant hyperinsulinemia. LH elevation seems to be secondary to hyperandrogenemia and is absent in the most obese cases. Overweight early pubertal girls have significant blunting of sleep-related LH production, which is the first hormonal change of puberty. The data are compatible with the possibility that excess adiposity may paradoxically subtly suppress hypothalamic-pituitary-gonadal function in early puberty although it is known to contribute to the early onset of puberty.
Rosenfield
Robert L
RL
Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA. robros@peds.bsd.uchicago.edu
Bordini
Brian
B
D000375:Aging / Q000502:physiology*; D000728:Androgens / Q000502:physiology*; D000818:Animals; D005260:Female; D006062:Gonadotropins / Q000096:biosynthesis*; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology; D009765:Obesity / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology; D011627:Puberty / Q000502:physiology*; D012741:Sexual Maturation / Q000502:physiology
D000728:Androgens; D006062:Gonadotropins; D007986:Luteinizing Hormone
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