title: Insulin-like growth factor-1 and zinc status of goitrous primary-school children in Arak, Islamic Republic of Iran.
abstract: Despite a successful national salt iodinization programme, endemic goitre still persists in Iranian children. In a cross-sectional study in Arak the prevalence of goitre was 5.2% in a sample of 6520 primary-school children. Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (ICF-1) and serum zinc. The mean urinary iodine levels of goitrous children and healthy children were 17.4 microg/dL and 15.3 microg/dL respectively, suggesting that iodine consumption was adequate. No significant differences were found between goitrous and healthy schoolchildren in mean levels of urinary iodine, serum IGF-1 or serum zinc. Other factors need be evaluated to, explain the residual prevalence of goitre.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran. rezvanfar@gmail.com
authors.forename: M R
authors.initials: MR
authors.lastname: Rezvanfar
authors.forename: H
authors.initials: H
authors.lastname: Farahany
authors.forename: M
authors.initials: M
authors.lastname: Rafiee
authors.forename: B
authors.initials: B
authors.lastname: Eshratee
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D006043:Goiter, Endemic / Q000453:epidemiology* / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000378:metabolism; D007455:Iodine / Q000172:deficiency / Q000627:therapeutic use / Q000652:urine; D007492:Iran; D008297:Male; D008403:Mass Screening; D009313:National Health Programs; D015995:Prevalence; D017673:Sodium Chloride, Dietary / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D013334:Students / Q000706:statistics & numerical data; D013963:Thyroid Hormones / Q000097:blood / Q000172:deficiency; D015032:Zinc / Q000097:blood / Q000172:deficiency
chemical_list: D017673:Sodium Chloride, Dietary; D013963:Thyroid Hormones; C034024:iodized salt; D007334:Insulin-Like Growth Factor I; D007455:Iodine; D015032:Zinc