Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.
This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha 2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of breast cancer (stages T0 - T1, T2 and T3) compared with normal control tissues (n = 33). Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases. Significant up-regulation of cofilin 1 mRNA was associated with stages T0 - T1 and T2; up-regulation seen at stage T3 was not significant compared with control tissue. Fascin mRNA levels were significantly reduced at all three tumour stages (T0 - T1, T2 and T3) compared with control tissue. In conclusion, some components of the actin cytoskeletal system might hold significant potential as targets in future cancer therapies.
Zhang
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Department of Obstetrics and Gynaecology, Tongji Hospital of Tongji University, Shanghai, China.
Tong
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D000185:Actinin / Q000235:genetics / Q000378:metabolism; D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D051338:Cofilin 1 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D018226:Fibroadenoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015870:Gene Expression; D006801:Humans; D008408:Mastectomy; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D020648:Peptide Elongation Factor 1 / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D055815:Young Adult
C111453:ACTN4 protein, human; C495810:CFL1 protein, human; D002352:Carrier Proteins; D051338:Cofilin 1; C503234:EEF1A2 protein, human; C502658:FSCN1 protein, human; D008840:Microfilament Proteins; D020648:Peptide Elongation Factor 1; D012333:RNA, Messenger; D000185:Actinin