title: Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses.
abstract: Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of the lymphotoxin beta receptor in these higher mammals was key to the development of these new functions. Here, we argue that lymphoid tissue inducer cells played a pivotal role not only in the development of organized lymphoid structures but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses that depend on an organized infrastructure to work. In this review, we concentrate on the role of this cell type in the making of a tolerant CD4 T cell repertoire and in the sustenance of CD4 T cell responses for protective immunity.
authors.affiliation: MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingha Medical School, Birmingham, UK.
authors.forename: Peter J L
authors.initials: PJ
authors.lastname: Lane
authors.forename: Fiona M
authors.initials: FM
authors.lastname: McConnell
authors.forename: David
authors.initials: D
authors.lastname: Withers
authors.forename: Fabrina
authors.initials: F
authors.lastname: Gaspal
authors.forename: Manoj
authors.initials: M
authors.lastname: Saini
authors.forename: Graham
authors.initials: G
authors.lastname: Anderson
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D005075:Biological Evolution; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*