Cancer metabolism: the Warburg effect today.
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with consequences for diagnosis and therapy. This review presents facts and perspectives on the Warburg effect for the 21st century.
Ferreira
Leonardo M R
LM
Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Rua dos Estudos, 3001-401 Coimbra, Portugal. leonardo_m_r_ferreira@yahoo.com
D000818:Animals; D019069:Cell Respiration / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005285:Fermentation / Q000502:physiology; D006019:Glycolysis / Q000502:physiology; D049674:History, 21st Century; D006801:Humans; D009369:Neoplasms / Q000266:history* / Q000378:metabolism*