title: Hydoroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus.
abstract: In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to possess significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 micronM, respectively.
authors.affiliation: Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
authors.forename: In-Ja
authors.initials: IJ
authors.lastname: Ryoo
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Ik-Soo
authors.initials: IS
authors.lastname: Lee
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Ahn
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Ick-Dong
authors.initials: ID
authors.lastname: Yoo
mesh_terms: D031584:Hibiscus / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D019272:Leukocyte Elastase / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D053491:Proteinase Inhibitory Proteins, Secretory; D019272:Leukocyte Elastase