Separating the good and evil of cardiac growth by CIB1 and calcineurin.
Ca(2+)-calcineurin-NFAT signaling plays a major role in promoting pathological cardiac hypertrophy. Heineke et al. (2010) show that CIB1 strongly enhances calcineurin activation and cardiac hypertrophy upon pathological stress, likely by functioning as a scaffold protein that exposes calcineurin to the L-Type Ca(2+) channel and the sarcolemma.
Frost
Robert J A
RJ
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, 75390-9148, USA.
Olson
Eric N
EN
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