Determinants of serum-induced SIRT1 expression in older men: the CHAMP study.
Circulating factors that have an effect on SIRT1 expression are influenced by caloric restriction. To determine the association between frailty and such circulating factors, we measured serum-induced SIRT1 expression from a nested cohort of frail (n = 77) and robust (n = 82) participants from Concord Health and Ageing in Men Project, a population-based study of community-dwelling men older than 70 years. Serum-induced SIRT1 expression was not different between frail and robust men (103.1 ± 17.0 versus 100.4 ± 19.3 μg/L). However, subsequent analyses showed that men with the lowest values (first quartile) were less likely to be frail (odds ratio = 0.5, 95% confidence interval = 0.2-1.0, p = .04) and had higher total body lean mass (p = .001) than the other participants. Serum-induced SIRT1 expression did not correlate with age, diseases, medications, albumin, fasting glucose, or lipids. Overall, there was no association between frailty and serum-induced SIRT1 expression; however, post hoc analysis suggested that there might be a paradoxical association between low serum-induced SIRT1 expression and robustness.
Le Couteur
David G
DG
Centre for Education and Research on Ageing, Concord Repatriation General Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia. david.lecouteur@sydney.edu.au
Benson
Vicky L
VL
McMahon
Aisling C
AC
Blyth
Fiona
F
Handelsman
David J
DJ
Seibel
Markus J
MJ
Kennerson
Marina
M
Naganathan
Vasi
V
Cumming
Robert G
RG
de Cabo
Rafael
R
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D016330:Frail Elderly; D006801:Humans; D008297:Male; D044967:Serum / Q000502:physiology*; D056564:Sirtuin 1 / Q000096:biosynthesis*
C447939:SIRT1 protein, human; D056564:Sirtuin 1
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