The role of plasminogen activator inhibitor-1 and angiotensin-converting enzyme gene polymorphisms in bronchopulmonary dysplasia.
BACKGROUND
Bronchopulmonary dysplasia (BPD) is a multifactorial disease of preterm infants that is characterized by airway injury, inflammation, and parencymal remodeling. Activation of the coagulation cascade leads to intraalveolar fibrin deposition in many inflammatory pulmonary disorders. Increased fibrin formation or decreased fibrinolysis may cause extravascular fibrin deposition. Extravascular fibrin deposits in septae and alveoli due to the altered fibrin turnover are the pathological hallmarks of BPD, which strongly indicate the importance of the imbalance in the competing activities of coagulation and fibrinolysis.


OBJECTIVE
We investigated the predictive value of variations in plasminogen activator inhibitor-1 (PAI-1) and angiotensin-converting enzyme (ACE) genes as molecular determinants for BPD in neonates.


METHODS
The study group comprised 98 preterm infants with BPD and a control group including 94 preterm infants without BPD. Restriction fragment size analyses were performed by visualizing digested polymerase chain reaction products for ACE and PAI-1 genotypes.


RESULTS
No significant associations were found between ACE, PAI-1 gene polymorphisms, and BPD phenotype in our population.


CONCLUSIONS
The two gene polymorphisms (PAI-1 and ACE) had no role in the development of BPD in our study. Further studies with other genes are required for the identification of molecular predisposing factors for BPD that may help in the development of new treatments.
Ince
Deniz Anuk
DA
Department of Pediatrics, Baskent University School of Medicine, Ankara, Turkey. denizanuk@yahoo.com
Atac
Fatma Belgin
FB
Ozkiraz
Servet
S
Dilmen
Ugur
U
Gulcan
Hande
H
Tarcan
Aylin
A
Ozbek
Namik
N
D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000196:embryology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000502:physiology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D007703:Peptidyl-Dipeptidase A
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