Seeing beyond the average cell: branching process models of cell proliferation, differentiation, and death during mouse brain development.
We develop a family of branching process models to study cerebral cortical development at the level of individual neural stem and progenitor cells (NS/PCs) and the neurons they produce. Population-level data about "the average NS/PC" is incorporated as constraints for exploring (i) heterogeneity in the proliferative neural cell types and (ii) variability in daughter cell fate decision making. Preliminary studies demonstrate this variability, generate testable hypotheses about heterogeneity, and motivate new experiments moving forward.
MacMillan
Hugh R
HR
Department of Mathematical Sciences, Clemson University, Clemson, SC 29634-0975, USA. hughrobertmacmillan@gmail.com
McConnell
Michael J
MJ
D000818:Animals; D016923:Cell Death / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008959:Models, Neurological; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology*
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