Pharmacologic development of male hormonal contraceptive agents.
The world population continues to increase dramatically despite the existence of contraceptive technology. The use of male hormonal contraception may help in preventing un intended pregnancies and managing future population growth. Male hormonal contraception relies on the administration of exogenous hormones to suppress spermatogenesis. Clinical trials have tested several regimens using testosterone, alone or in combination with a progestin. These regimens were shown to be >90% effective in preventing conception and were not associated with serious adverse events.
Roth
M Y
MY
Center for Research in Reproduction and Contraception, University of Washington,Seattle, Washington, USA. mylang@u.washington.edu
Amory
J K
JK
D000818:Animals; D003272:Contraceptive Agents, Male / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D015195:Drug Design; D015507:Drugs, Investigational / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013092:Spermatogenesis-Blocking Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
D003272:Contraceptive Agents, Male; D015507:Drugs, Investigational; D013092:Spermatogenesis-Blocking Agents
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