In vivo study on the expression pattern of resistin in patients with abdominal aortic aneurysm.
OBJECTIVE
To study the expression pattern of resistin in abdominal aortic aneurysms and to correlate its plasma levels to aneurysm size and statin therapy.


METHODS
From 25 patients on regular and 38 patients without statin therapy tissue specimen and plasma samples were obtained for analysis.


RESULTS
Demographic data, past medical history, and body mass index showed no significant differences between the statin and no statin group. Immunohistochemistry showed positive stainings for resistin in all sections and in part colocalization to CD 68 positive cells. Patients with large aneurysms showed significant correlation of C-reactive protein (CRP) and interleukin 10 (IL-10) levels; patients on statin medication had significantly lower plasma levels of resistin and CRP.


CONCLUSIONS
In contrast to IL-10 and CRP plasma levels of resistin are not correlated to aneurysm diameter; yet statin therapy results in decrease of resistin and CRP, suggesting an anti-inflammatory action in patients with abdominal aortic aneurysms (AAAs).
Muehling
Bernd M
BM
Department of Thoracic and Vascular Surgery, University of Ulm, Ulm, Germany. bernd.muehling@uniklinik-ulm.de
Paintner
Agnes
A
Marx
Nikolaus
N
Barth
Thomas F E
TF
Babiak
Christina
C
Orend
Karl H
KH
D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001012:Aorta, Abdominal / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D002097:C-Reactive Protein / Q000032:analysis; D057510:Endovascular Procedures; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005858:Germany; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures
D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C508609:IL10 protein, human; D018836:Inflammation Mediators; C499624:RETN protein, human; D052243:Resistin; D016753:Interleukin-10; D002097:C-Reactive Protein