Social interaction modulates autonomic, inflammatory, and depressive-like responses to cardiac arrest and cardiopulmonary resuscitation.
Psychological factors, including depression and social isolation, are important determinants of cardiovascular health. The current study uses a well-validated mouse model of cardiac arrest/cardiopulmonary resuscitation (CA/CPR) to examine the effect of social environment on several pathophysiological and behavioral responses to cerebral ischemia. Male experimental mice were either housed in pairs with an ovariectomized female or socially isolated for the duration of the experiment. Cardiac arrest increased the mRNA expression of the proinflammatory cytokines TNF-α, IL-1β, and IL-6, as well as the microglia marker MAC-1; expression of each of these factors, except IL-6, was further increased among socially isolated mice. Furthermore, socially isolated animals exposed to the CA/CPR procedure displayed significantly higher levels of neuronal cell death and microglia staining within the hippocampus at 7 d following surgery. Social isolation also exacerbated CA/CPR-induced depressive-like behavior and cardiac autonomic dysregulation. In the absence of ischemic damage, social environment had no significant effect on the expression of neuronal cell death, autonomic cardiac control, or behavior. Together, these data suggest that social factors influence the pathophysiological trajectory following cardiac arrest.
Norman
Greg J
GJ
Department of Psychology and Neuroscience, Ohio State University, Columbus, OH 43210, USA. norman.106@osu.edu
Zhang
Ning
N
Morris
John S
JS
Karelina
Kate
K
Berntson
Gary G
GG
DeVries
A Courtney
AC
D000818:Animals; D016887:Cardiopulmonary Resuscitation; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003863:Depression / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005786:Gene Expression Regulation; D006323:Heart Arrest / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010052:Ovariectomy; D012333:RNA, Messenger / Q000235:genetics; D012919:Social Behavior
D016207:Cytokines; D018836:Inflammation Mediators; D012333:RNA, Messenger
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4525-30
19246380
Science. 1988 Jul 29;241(4865):540-5
3399889
Circulation. 2009 May 19;119(19):2597-605
19414637
Neurol Clin. 2006 Feb;24(1):1-21
16443127
J Cereb Blood Flow Metab. 2009 Oct;29(10):1673-82
19553908
Neuroscience. 2009 Feb 6;158(3):1098-111
18597949
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5895-900
19307557
J Neuroimmunol. 2004 Feb;147(1-2):87-90
14741434
Med Sci Monit. 2004 Jul;10(7):CR307-15
15232505
Psychophysiology. 1994 Nov;31(6):572-85
7846218
Stroke. 1998 Nov;29(11):2311-7
9804639
Psychosom Med. 1984 Jan-Feb;46(1):7-14
6701256
Circulation. 2007 Feb 6;115(5):e69-171
17194875
Circulation. 2002 Jul 30;106(5):562-8
12147537
Brain Pathol. 2000 Jan;10(1):145-52
10668904
Stroke. 2009 Nov;40(11):3601-7
19762688
Acta Neurol Scand. 2005 Jun;111(6):360-5
15876336
Exp Neurol. 2009 Dec;220(2):276-82
19733169
Genome Biol. 2007;8(9):R189
17854483
Psychophysiology. 1997 Nov;34(6):623-48
9401419
Rev Neurosci. 2000;11(1):53-8
10716655
Br J Sports Med. 2009 Sep;43(9):702-7
19734506
Psychosom Med. 2010 Jul;72(6):519-26
20466999
Stroke. 2003 Jan;34(1):138-43
12511765
Mol Psychiatry. 2008 Oct;13(10):913-5
18800053
Crit Care Med. 2009 Feb;37(2):403-9
19114905
Arch Intern Med. 2006 Jan 23;166(2):195-200
16432088
Circulation. 2009 Jul 14;120(2):134-40, 3p following 140
19564557
Resuscitation. 1996 Apr;31(2):135-40
8733020
Clin Auton Res. 2008 Dec;18(6):308-17
18850312
J Cereb Blood Flow Metab. 2006 May;26(5):654-65
16121126
Resuscitation. 2009 Oct;80(10):1119-23
19631442
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H59-68
18456734
J Cereb Blood Flow Metab. 2008 May;28(5):927-38
18000511
Psychophysiology. 2008 Jul;45(4):643-52
18282204
Stroke. 2008 Oct;39(10):2910-7
18658035
Nat Rev Immunol. 2009 Jun;9(6):418-28
19461672
Biol Psychol. 2007 Feb;74(2):224-42
17182165