Regulatory T cells and T helper subsets in breast-fed infants with hematochezia caused by allergic colitis.
The objective of our study was to investigate the prevalence of CD4 T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence of activated CD4CD25 cells and FoxP3 regulatory cells, and a shift to TH2 direction in balance compared with controls. These alterations are normalized upon cessation of AC symptoms on elemental L-amino acid formula. These findings suggest the importance of antigen exposure in AC in infancy.
Cseh
Aron
A
Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary.
Molnár
Kriszta
K
Pintér
Petra
P
Szalay
Balazs
B
Szebeni
Beata
B
Treszl
Andras
A
Arató
Andras
A
Vásárhelyi
Barna
B
Veres
Gabor
G
D000596:Amino Acids / Q000494:pharmacology / Q000627:therapeutic use; D000941:Antigens / Q000276:immunology; D001942:Breast Feeding; D015704:CD4 Antigens; D016022:Case-Control Studies; D003092:Colitis / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology; D006471:Gastrointestinal Hemorrhage / Q000276:immunology*; D006801:Humans; D007223:Infant; D041943:Infant Formula; D053645:Interleukin-2 Receptor alpha Subunit; D008213:Lymphocyte Activation; D008297:Male; D008895:Milk, Human / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D058408:Th1-Th2 Balance
D000596:Amino Acids; D000941:Antigens; D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit