Modeling of dispersed-drug delivery from planar polymeric systems: optimizing analytical solutions.
Analytical solutions for the case of controlled dispersed-drug release from planar non-erodible polymeric matrices, based on Refined Integral Method, are presented. A new adjusting equation is used for the dissolved drug concentration profile in the depletion zone. The set of equations match the available exact solution. In order to illustrate the usefulness of this model, comparisons with experimental profiles reported in the literature are presented. The obtained results show that the model can be employed in a broad range of applicability.
Helbling
Ignacio M
IM
Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas, Centro Científico Tecnológico, Ruta Nacional 168, Paraje El Pozo 3000, Santa Fe, Argentina. ihelbling@santafe-conicet.gov.ar
Ibarra
Juan C D
JC
Luna
Julio A
JA
Cabrera
María I
MI
Grau
Ricardo J A
RJ
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D007700:Kinetics; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012996:Solutions
D003692:Delayed-Action Preparations; D011108:Polymers; D012996:Solutions