Prevalence of human papillomavirus genotypes in northern Taiwanese women.
The prevalence of Human Papillomavirus (HPV) in the general population of northern Taiwan is described. A total of 343 consecutive cervical swabs from women visiting the medical center for routine gynecologic care were included. Cervical cell cytology was examined by the Papanicolaou (Pap) test, and a PCR-based hybridization gene chip analysis was used to identify HPV genotypes. The HPV prevalence in the overall population was 32.4%. When divided into two groups according to cytology, 20.9% of women with normal cytology were HPV positive while 75.3% of women with abnormal cytology were HPV positive. Among positive samples, 68.5% were single type infections while 31.5% harbored multiple HPV types. A total of 32 types of HPV were identified; the leading five were HPV16 (5.8%), HPV58 (5.3%), HPV53 (4.1%), HPV52 (3.8%), and HPV18 (2.3%). Our results constitute baseline data and may provide important implications for future prophylactic programs. The relatively high prevalence of HPV 58, 53, and 52 among northern Taiwanese women has important implications for vaccine development.
Tsao
Kuo-Chien
KC
Department of Laboratory Medicine, Lin-kou Chang Gung Memorial Hospital, Taoyuan, Taiwan. kctsao@adm.cgmh.org.tw
Huang
Chung-Guei
CG
Kuo
Yung-Bin
YB
Chang
Ting-Chang
TC
Sun
Chien-Feng
CF
Chang
C Allen
CA
Yang
Su-Li
SL
Chan
Err-Cheng
EC
D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology; D014626:Vaginal Smears; D055815:Young Adult
D004279:DNA, Viral