Synthesis of the natural enantiomer of neplanocin B.
(-)-Neplanocin B, the natural isomer of a component of the neplanocin family was diasteroselectively synthesized from 2,3-O-isopropylidene-D-1,4-ribonolactone. However, when evaluated against several DNA and RNA viruses in cell culture experiments, it did not show any antiviral activity.
Hamon
Nadège
N
Institut des Biomolécules Max Mousseron, UMR CNRS-UM, Université Montpellier, France.
Uttaro
Jean-Pierre
JP
Mathé
Christophe
C
Périgaud
Christian
C
D000192:Actinomycetales / Q000737:chemistry; D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013237:Stereoisomerism; D014777:Virus Diseases / Q000188:drug therapy; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; C031097:neplanocin B; D000241:Adenosine