Structure of a stacked anthraquinone-DNA complex.
The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs.
De Luchi
Daniela
D
Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Spain.
Usón
Isabel
I
Wright
Glenford
G
Gouyette
Catherine
C
Subirana
Juan A
JA
D000880:Anthraquinones / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D013237:Stereoisomerism
D000880:Anthraquinones; D004247:DNA
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