NF-kappaB: much learned, much to learn.
Although NF-kappaB (nuclear factor kappaB) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-kappaB: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-kappaB signaling by some of the leading investigators in the field.
Razani
Bahram
B
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.
Cheng
Genhong
G
D000222:Adaptation, Physiological; D006801:Humans; D007113:Immunity, Innate; D016328:NF-kappa B / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction
D016328:NF-kappa B