[Paracetamol for perioperative analgesia. Old substance - new insights].
Since paracetamol was first synthesized in 1878 it has become one of the most popular and widely used drugs for the first-line treatment of fever and pain. The reasons for this popularity are a wide variety of formulations, an assumed positive safety record and the wide availability as an over-the-counter drug. However, recently several studies questioned the positive risk-benefit ratio of paracetamol for postoperative pain by observing several possible adverse effects and limitations. The aim of the present review is to give an update of the recent literature on the efficacy of paracetamol for postoperative pain and on the value of the clinical relevance of different adverse effects of paracetamol. Finally, based on the current findings the authors try to assess the role of paracetamol for the treatment of postoperative pain.
Zahn
P K
PK
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48129 Münster. pogatzki@anit.uni-muenster.de
Sabatowski
R
R
Schug
S A
SA
Stamer
U M
UM
Pogatzki-Zahn
E M
EM
D000082:Acetaminophen / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000473:pathology; D002626:Chemistry, Pharmaceutical; D002648:Child; D004338:Drug Combinations; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D019990:Perioperative Care; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment
D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D004338:Drug Combinations; D000082:Acetaminophen
Anesthesiology. 2005 Dec;103(6):1296-304
16306743
Cochrane Database Syst Rev. 2008 Oct 08;(4):CD004602
18843665
Health Technol Assess. 2010 Mar;14(17):1-153, iii-iv
20346263
Hepatology. 2005 Dec;42(6):1364-72
16317692
Anesthesiology. 1999 Feb;90(2):411-21
9952146
BMJ. 2008 Jun 14;336(7657):1324
18556283
Br J Anaesth. 2007 Mar;98(3):372-9
17284514
Pharmacotherapy. 2008 Oct;28(10):1205-10
18823215
Thorax. 2000 Apr;55(4):266-70
10722764
Drugs. 2009;69(1):101-13
19192939
Br J Clin Pharmacol. 1998 Sep;46(3):237-43
9764964
Clin Ther. 2006 May;28(5):783-93
16861100
N Engl J Med. 1991 Jan 17;324(3):155-60
1984193
Lancet Neurol. 2009 May;8(5):434-40
19297248
Minerva Anestesiol. 2009 Nov;75(11):644-53
19881460
Lancet. 2008 Sep 20;372(9643):1039-48
18805332
Pediatrics. 2007 Apr;119(4):766-71
17403848
Ann Surg. 1996 Apr;223(4):420-7
8633921
Eur J Clin Pharmacol. 2010 Jul;66(7):713-9
20300741
JAMA. 2006 Jul 5;296(1):87-93
16820551
Eur Respir J. 2000 Nov;16(5):817-23
11153577
Br J Anaesth. 2005 Apr;94(4):505-13
15681586
Pharmacotherapy. 2007 Sep;27(9):1219-30
17723075
Int J Biochem Cell Biol. 2005 Aug;37(8):1727-37
15878691
Pharmacoepidemiol Drug Saf. 2002 Dec;11(8):687-93
12512245
Paediatr Anaesth. 2009 Apr;19(4):289-95
19335341
Eur J Pain. 2006 May;10(4):287-333
16095934
J Pediatr Gastroenterol Nutr. 2008 Oct;47(4):395-405
18852631
Br J Anaesth. 2005 May;94(5):642-8
15790675
J Clin Pharm Ther. 2007 Oct;32(5):449-55
17875110
Hypertension. 2005 Sep;46(3):500-7
16103274
Pharmacoepidemiol Drug Saf. 2009 May;18(5):417-9
19248080
J Clin Gastroenterol. 2009 Apr;43(4):342-9
19169150
Trends Pharmacol Sci. 2009 Oct;30(10):503-8
19762092
Circulation. 2006 Mar 28;113(12):1578-87
16534006
Lancet. 2006 Aug 19;368(9536):704
16920476
J Asthma. 2008 Oct;45(8):675-6
18951259
Curr Opin Anaesthesiol. 2009 Oct;22(5):588-93
19606021
J Cardiothorac Vasc Anesth. 2005 Jun;19(3):306-9
16130055
Am J Respir Crit Care Med. 2004 Apr 1;169(7):836-41
14711794
Ann Emerg Med. 2006 Sep;48(3):315-8
16934651
Drug Saf. 2003;26(13):925-35
14583068
Prostaglandins. 1989 Mar;37(3):311-5
2664901
Addict Biol. 2002 Apr;7(2):191-206
12006215
Pain. 2004 Jan;107(1-2):86-90
14715393
Br J Anaesth. 2005 Jul;95(1):59-68
15668207
Crit Care Med. 1997 Jan;25(1):78-84
8989180
Obstet Gynecol. 2010 Jan;115(1):109-115
20027042
Eur J Clin Pharmacol. 2010 Jan;66(1):97-103
19779704
J Pharmacol Exp Ther. 2005 Oct;315(1):1-7
15879007
Pharmacoepidemiol Drug Saf. 2010 May;19(5):511-7
20333776
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31
12242329
Paediatr Anaesth. 2008 Oct;18(10):915-21
18811827
Eur Respir J. 2008 Nov;32(5):1231-6
18579547
Paediatr Drugs. 2000 May-Jun;2(3):223-38
10937472
CNS Drug Rev. 2006 Fall-Winter;12(3-4):250-75
17227290
N Engl J Med. 2009 Nov 26;361(22):2105-7
19940297
Eur J Clin Pharmacol. 2004 Aug;60(6):431-7
15197519
Int J Epidemiol. 2009 Jun;38(3):706-14
19332503
Z Gastroenterol. 2009 Sep;47(9):807-13
19750427
Paediatr Anaesth. 2007 Jul;17(7):684-7
17564651
Eur J Clin Pharmacol. 2010 Sep;66(9):855-8
20607221
FASEB J. 2008 Feb;22(2):383-90
17884974
Eur J Clin Pharmacol. 2003 Aug;59(4):297-302
12845506
Mol Nutr Food Res. 2009 Jun;53(6):770-9
19194968
Pharmacogenomics. 2010 Jun;11(6):843-64
20504256
Br J Clin Pharmacol. 2005 Mar;59(3):371-4
15752384
Br J Clin Pharmacol. 1992 Jul;34(1):79-81
1633071
Int J Epidemiol. 2010 Jun;39(3):790-4
20356852
Br J Anaesth. 2010 Jan;104(1):80-8
20007794
Handb Exp Pharmacol. 2010;(196):369-405
20020268
Intensive Care Med. 2000 Sep;26(9):1408
11089781
Am J Ther. 2005 Jan-Feb;12(1):46-55
15662292
Anesth Analg. 2010 Apr 1;110(4):1170-9
20142348
Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001547
19160199
Haematologica. 2006 Dec;91(12):1621-7
17145598
J Allergy Clin Immunol. 2009 Oct;124(4):649-51
19767081
Clin Pharmacol Ther. 2006 Apr;79(4):371-8
16580905
Emerg Med J. 2008 Apr;25(4):213-6
18356351
Am J Ther. 2002 May-Jun;9(3):225-33
11941382
Pain Med. 2010 Mar;11(3):369-78
20447306
Acta Anaesthesiol Scand. 2006 Jul;50(6):673-7
16987360
Acta Anaesthesiol Scand. 2001 Jan;45(1):20-9
11152028
Br J Anaesth. 2005 Jun;94(6):710-4
15833778
Acta Anaesthesiol Scand. 2004 Aug;48(7):867-70
15242431
N Engl J Med. 2008 Jul 17;359(3):285-92
18635433
Inflammopharmacology. 2010 Apr;18(2):47-55
20213329
Am J Emerg Med. 2003 Jan;21(1):48-50
12563581
BMJ. 2006 May 13;332(7550):1133
16690670
Pain. 2008 Jul 15;137(2):441-451
18417292