title: Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action.
abstract: The peer-reviewed marine pharmacology literature in 2007-8 is covered in this review, which follows a similar format to the previous 1998-2006 reviews of this series. The preclinical pharmacology of structurally characterized marine compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 74 marine natural products. Additionally, 59 marine compounds were reported to affect the cardiovascular, immune and nervous systems as well as to possess anti-inflammatory effects. Finally, 65 marine metabolites were shown to bind to a variety of receptors and miscellaneous molecular targets, and thus upon further completion of mechanism of action studies, will contribute to several pharmacological classes. Marine pharmacology research during 2007-8 remained a global enterprise, with researchers from 26 countries, and the United States, contributing to the preclinical pharmacology of 197 marine compounds which are part of the preclinical marine pharmaceuticals pipeline. Sustained preclinical research with marine natural products demonstrating novel pharmacological activities, will probably result in the expansion of the current marine pharmaceutical clinical pipeline, which currently consists of 13 marine natural products, analogs or derivatives targeting a limited number of disease categories.
authors.affiliation: Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA. amayer@midwestern.edu
authors.forename: Alejandro M S
authors.initials: AM
authors.lastname: Mayer
authors.forename: Abimael D
authors.initials: AD
authors.lastname: Rodríguez
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008386:Marine Biology; D009420:Nervous System / Q000187:drug effects; D004364:Pharmaceutical Preparations; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000935:Antifungal Agents; D000962:Antimalarials; D000981:Antiprotozoal Agents; D000995:Antitubercular Agents; D000998:Antiviral Agents; D001688:Biological Products; D004364:Pharmaceutical Preparations
references.citation: Int J Dev Neurosci. 2007 Feb;25(1):63-8
references.pmid: 17092682
references.citation: J Herb Pharmacother. 2007;7(1):73-86
references.pmid: 17594989
references.citation: Biotechnol J. 2008 Jul;3(7):904-15
references.pmid: 18543244
references.citation: Nat Prod Rep. 2007 Feb;24(1):31-86
references.pmid: 17268607
references.citation: Biochim Biophys Acta. 2007 Nov;1770(11):1513-9
references.pmid: 17804167
references.citation: Glycobiology. 2008 Dec;18(12):1016-27
references.pmid: 18796647
references.citation: J Antibiot (Tokyo). 2008 Jan;61(1):40-2
references.pmid: 18305359
references.citation: Bioorg Med Chem Lett. 2008 Oct 15;18(20):5377-80
references.pmid: 18824352
references.citation: Chem Biodivers. 2008 Jan;5(1):93-100
references.pmid: 18205129
references.citation: J Nat Prod. 2007 Jun;70(6):984-8
references.pmid: 17441769
references.citation: J Nat Prod. 2007 Jan;70(1):124-7
references.pmid: 17253864
references.citation: J Nat Prod. 2007 Feb;70(2):196-201
references.pmid: 17315959
references.citation: Mar Biotechnol (NY). 2004 Jan-Feb;6(1):37-52
references.pmid: 14583811
references.citation: J Biosci Bioeng. 2007 Aug;104(2):111-6
references.pmid: 17884655
references.citation: Org Lett. 2008 Jun 5;10(11):2099-102
references.pmid: 18454539
references.citation: J Nat Prod. 2008 Sep;71(9):1579-84
references.pmid: 18683985
references.citation: J Nat Prod. 2008 Sep;71(9):1616-9
references.pmid: 18763828
references.citation: Mini Rev Med Chem. 2008 Oct;8(11):1088-94
references.pmid: 18855725
references.citation: J Nat Prod. 2008 Nov;71(11):1819-24
references.pmid: 18973388
references.citation: Eur J Cancer. 2004 Dec;40(18):2676-704
references.pmid: 15571951
references.citation: Phytochemistry. 2008 Oct;69(13):2490-4
references.pmid: 18718619
references.citation: Steroids. 2007 Dec;72(14):908-13
references.pmid: 17889913
references.citation: Bioorg Med Chem. 2007 Nov 1;15(21):6627-31
references.pmid: 17765551
references.citation: J Nat Prod. 2007 Mar;70(3):412-6
references.pmid: 17309301
references.citation: Phytother Res. 2007 May;21(5):423-6
references.pmid: 17236179
references.citation: J Biochem Mol Biol. 2007 Sep 30;40(5):832-8
references.pmid: 17927919
references.citation: J Am Chem Soc. 2008 Apr 2;130(13):4507-16
references.pmid: 18331040
references.citation: Biol Pharm Bull. 2008 Apr;31(4):691-5
references.pmid: 18379064
references.citation: Fitoterapia. 2008 Jul;79(5):374-7
references.pmid: 18504078
references.citation: Appl Microbiol Biotechnol. 2008 Dec;81(4):755-64
references.pmid: 18813920
references.citation: Curr Opin Investig Drugs. 2007 Jul;8(7):525-30
references.pmid: 17659472
references.citation: Mar Drugs. 2008;6(3):407-17
references.pmid: 19005576
references.citation: Int Immunopharmacol. 2007 Dec 15;7(13):1825-33
references.pmid: 17996695
references.citation: J Nat Prod. 2008 Feb;71(2):232-40
references.pmid: 18220352
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jul;132(3):315-39
references.pmid: 12161166
references.citation: J Nat Prod. 2008 Oct;71(10):1714-9
references.pmid: 18817444
references.citation: Curr Med Chem. 2007;14(16):1789-803
references.pmid: 17627517
references.citation: Expert Opin Pharmacother. 2008 Jun;9(9):1575-83
references.pmid: 18518786
references.citation: J Nat Prod. 2007 Jul;70(7):1110-3
references.pmid: 17567172
references.citation: Bioorg Med Chem Lett. 2008 Jun 15;18(12):3589-92
references.pmid: 18487046
references.citation: Biochemistry. 2007 Oct 9;46(40):11410-20
references.pmid: 17867706
references.citation: Planta Med. 2007 Nov;73(14):1464-8
references.pmid: 17948168
references.citation: Methods. 2007 Aug;42(4):358-76
references.pmid: 17560324
references.citation: J Nat Prod. 2007 Mar;70(3):432-5
references.pmid: 17311456
references.citation: J Nat Prod. 2007 Jan;70(1):83-8
references.pmid: 17253854
references.citation: Mar Drugs. 2008 Jan 22;6(1):1-11
references.pmid: 18648669
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2007 Aug;147(4):645-56
references.pmid: 17543561
references.citation: Trends Pharmacol Sci. 2010 Jun;31(6):255-65
references.pmid: 20363514
references.citation: Biofouling. 2007;23(1-2):131-7
references.pmid: 17453737
references.citation: J Nat Prod. 2008 Nov;71(11):1793-9
references.pmid: 18939864
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2008 Apr;377(2):139-48
references.pmid: 18270688
references.citation: J Antibiot (Tokyo). 2008 Apr;61(4):250-3
references.pmid: 18503206
references.citation: J Antibiot (Tokyo). 2008 Mar;61(3):192-4
references.pmid: 18503198
references.citation: J Nutr. 2008 Mar;138(3):476-81
references.pmid: 18287352
references.citation: Org Lett. 2008 Feb 21;10(4):629-31
references.pmid: 18205372
references.citation: J Nat Prod. 2007 Apr;70(4):689-710
references.pmid: 17362037
references.citation: Nat Prod Rep. 2007 Dec;24(6):1225-44
references.pmid: 18033577
references.citation: J Agric Food Chem. 2007 Oct 17;55(21):8516-22
references.pmid: 17894451
references.citation: J Neurosci Res. 2008 Apr;86(5):1169-77
references.pmid: 18092356
references.citation: Carbohydr Res. 2007 Nov 5;342(15):2326-30
references.pmid: 17631282
references.citation: J Invertebr Pathol. 2008 Oct;99(2):141-5
references.pmid: 18501924
references.citation: FEBS J. 2007 Jan;274(1):125-36
references.pmid: 17140417
references.citation: Peptides. 2008 Oct;29(10):1700-7
references.pmid: 18588930
references.citation: Prog Lipid Res. 2008 Jan;47(1):50-61
references.pmid: 18023422
references.citation: J Agric Food Chem. 2007 Aug 22;55(17):6923-8
references.pmid: 17655246
references.citation: Arch Pharm Res. 2007 Jul;30(7):812-5
references.pmid: 17703730
references.citation: J Med Chem. 2007 Nov 15;50(23):5600-7
references.pmid: 17941622
references.citation: J Nat Prod. 2008 Sep;71(9):1625-9
references.pmid: 18693761
references.citation: J Nat Prod. 2007 Dec;70(12):1850-3
references.pmid: 18044840
references.citation: J Nat Prod. 2008 Oct;71(10):1732-7
references.pmid: 18842058
references.citation: J Nat Prod. 2008 May;71(5):750-4
references.pmid: 18361518
references.citation: Steroids. 2007 Sep;72(9-10):682-5
references.pmid: 17610922
references.citation: J Antibiot (Tokyo). 2007 Nov;60(11):667-73
references.pmid: 18057695
references.citation: J Nat Prod. 2007 Feb;70(2):169-78
references.pmid: 17315957
references.citation: J Org Chem. 2007 Feb 16;72(4):1218-25
references.pmid: 17253745
references.citation: Phytochemistry. 2008 Aug;69(11):2193-9
references.pmid: 18572208
references.citation: J Nat Prod. 2007 Dec;70(12):2042-4
references.pmid: 18052030
references.citation: J Org Chem. 2007 Dec 7;72(25):9842-5
references.pmid: 17988148
references.citation: J Nat Prod. 2008 Oct;71(10):1754-9
references.pmid: 18831569
references.citation: J Nat Prod. 2007 Nov;70(11):1812-5
references.pmid: 17979246
references.citation: Toxicon. 2007 Sep 15;50(4):490-7
references.pmid: 17570456
references.citation: Eur J Cancer. 2006 Sep;42(14):2241-70
references.pmid: 16901686
references.citation: J Nat Prod. 2008 Apr;71(4):570-5
references.pmid: 18321059
references.citation: J Nat Prod. 2007 Mar;70(3):353-60
references.pmid: 17291041
references.citation: Curr Opin Pharmacol. 2008 Oct;8(5):557-63
references.pmid: 18524678
references.citation: Biol Pharm Bull. 2007 Sep;30(9):1792-5
references.pmid: 17827742
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2005 Mar-Apr;140(3-4):265-86
references.pmid: 15919242
references.citation: J Nat Prod. 2007 May;70(5):846-8
references.pmid: 17378608
references.citation: Nat Prod Rep. 2007 Apr;24(2):278-97
references.pmid: 17389998
references.citation: Molecules. 2008 Aug 12;13(8):1671-95
references.pmid: 18794778
references.citation: J Invertebr Pathol. 2008 Nov;99(3):286-93
references.pmid: 18621054
references.citation: Mol Immunol. 2007 Mar;44(8):1961-8
references.pmid: 17092560
references.citation: J Nat Prod. 2007 Jul;70(7):1210-3
references.pmid: 17602526
references.citation: Nat Prod Rep. 2008 Feb;25(1):35-94
references.pmid: 18250897
references.citation: J Agric Food Chem. 2007 Aug 22;55(17):6984-8
references.pmid: 17665931
references.citation: Eur J Cancer. 2008 Nov;44(16):2357-87
references.pmid: 18701274
references.citation: Anticancer Agents Med Chem. 2008 Aug;8(6):646-82
references.pmid: 18690828
references.citation: J Nat Prod. 2007 Jun;70(6):936-40
references.pmid: 17497807
references.citation: J Antibiot (Tokyo). 2008 Jan;61(1):18-26
references.pmid: 18305355
references.citation: J Nat Prod. 2007 Apr;70(4):563-6
references.pmid: 17319723
references.citation: Phytother Res. 2007 Feb;21(2):153-6
references.pmid: 17128433
references.citation: J Org Chem. 2007 Feb 16;72(4):1211-7
references.pmid: 17256905
references.citation: Bioorg Med Chem Lett. 2008 Dec 1;18(23):6130-4
references.pmid: 18938081
references.citation: Biochem Pharmacol. 2008 Feb 1;75(3):603-17
references.pmid: 17919455
references.citation: Curr Med Chem. 2007;14(4):479-500
references.pmid: 17305548
references.citation: Biopolymers. 2007;88(2):208-16
references.pmid: 17285588
references.citation: Phytochemistry. 2008 Oct;69(14):2621-6
references.pmid: 18804825
references.citation: Curr Pharm Des. 2007;13(6):653-60
references.pmid: 17346180
references.citation: Bioorg Med Chem. 2007 Nov 1;15(21):6834-45
references.pmid: 17765547
references.citation: J Antibiot (Tokyo). 2008 Mar;61(3):149-57
references.pmid: 18503193
references.citation: Biosci Biotechnol Biochem. 2006 Nov;70(11):2807-11
references.pmid: 17090915
references.citation: J Nat Prod. 2008 Sep;71(9):1530-7
references.pmid: 18698821
references.citation: Mar Drugs. 2008 Jan 23;6(1):12-24
references.pmid: 18648671
references.citation: J Am Chem Soc. 2007 Mar 14;129(10):3007-12
references.pmid: 17311384
references.citation: Org Lett. 2007 Aug 2;9(16):3045-8
references.pmid: 17630753
references.citation: Science. 2009 Aug 28;325(5944):1089-93
references.pmid: 19713519
references.citation: Bioorg Med Chem. 2008 Sep 1;16(17):7921-6
references.pmid: 18693022
references.citation: J Nat Prod. 2007 Nov;70(11):1753-60
references.pmid: 17963357
references.citation: BMC Complement Altern Med. 2008 Jul 10;8:38
references.pmid: 18613983
references.citation: Int J Biol Macromol. 2007 Oct 1;41(4):369-75
references.pmid: 17602734
references.citation: Angew Chem Int Ed Engl. 2008;47(7):1202-23
references.pmid: 18076006
references.citation: J Nat Prod. 2008 Mar;71(3):300-8
references.pmid: 18198837
references.citation: Int J Cancer. 2003 Jun 20;105(3):291-9
references.pmid: 12704660
references.citation: J Nat Prod. 2007 Apr;70(4):628-31
references.pmid: 17346077
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2007 May;145(4):553-81
references.pmid: 17392033
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2008 Sep;151(1):110-7
references.pmid: 18593604
references.citation: J Org Chem. 2007 Sep 14;72(19):7386-9
references.pmid: 17715964
references.citation: Phytochemistry. 2007 Apr;68(7):954-79
references.pmid: 17336349
references.citation: Biochim Biophys Acta. 2009 May;1790(5):283-308
references.pmid: 19303911
references.citation: J Antibiot (Tokyo). 2008 Jun;61(6):379-86
references.pmid: 18667786
references.citation: Mol Immunol. 2007 Mar;44(8):1922-34
references.pmid: 17067680
references.citation: FEMS Microbiol Lett. 2008 Feb;279(2):243-50
references.pmid: 18093138
references.citation: Mini Rev Med Chem. 2008 Jul;8(8):740-54
references.pmid: 18673130
references.citation: J Org Chem. 2007 Sep 14;72(19):7343-51
references.pmid: 17715978
references.citation: J Nat Prod. 2007 Jan;70(1):111-3
references.pmid: 17253860
references.citation: Bioorg Med Chem Lett. 2007 Aug 1;17(15):4387-91
references.pmid: 17587569
references.citation: J Antibiot (Tokyo). 2008 Mar;61(3):142-8
references.pmid: 18503192
references.citation: J Nat Prod. 2007 Sep;70(9):1454-7
references.pmid: 17845000
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2007 Apr;146(4):521-9
references.pmid: 17292649
references.citation: Curr Opin Drug Discov Devel. 2007 Mar;10(2):145-52
references.pmid: 17436549
references.citation: Antiviral Res. 2008 Jan;77(1):64-71
references.pmid: 17888523
references.citation: J Nat Prod. 2007 Mar;70(3):397-401
references.pmid: 17328572
references.citation: J Asian Nat Prod Res. 2008 May-Jun;10(5-6):521-9
references.pmid: 18470804
references.citation: J Nat Prod. 2007 Apr;70(4):504-9
references.pmid: 17309298
references.citation: J Med Food. 2008 Sep;11(3):443-53
references.pmid: 18800890
references.citation: J Nat Prod. 2008 Dec;71(12):2049-52
references.pmid: 19012435
references.citation: J Nat Prod. 2008 Sep;71(9):1544-50
references.pmid: 18715036
references.citation: Mar Biotechnol (NY). 2008 May-Jun;10(3):278-89
references.pmid: 18172723
references.citation: Bioorg Med Chem Lett. 2007 Oct 1;17(19):5366-9
references.pmid: 17716892
references.citation: Int J Biol Macromol. 2008 Nov 1;43(4):346-51
references.pmid: 18694781
references.citation: Org Lett. 2008 Jun 19;10(12):2481-4
references.pmid: 18498148
references.citation: J Appl Microbiol. 2008 Jun;104(6):1675-84
references.pmid: 18194244
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2008 Feb;149(2):394-400
references.pmid: 18055243
references.citation: J Nat Prod. 2007 Jul;70(7):1188-90
references.pmid: 17564467
references.citation: J Nat Prod. 2007 Nov;70(11):1691-5
references.pmid: 17988093
references.citation: Biochem Pharmacol. 2007 Nov 1;74(9):1330-9
references.pmid: 17868650
references.citation: Biomacromolecules. 2007 Jun;8(6):1765-74
references.pmid: 17458931
references.citation: Bioorg Med Chem. 2008 Feb 1;16(3):1073-83
references.pmid: 18006319
references.citation: J Nat Prod. 2008 Jan;71(1):28-30
references.pmid: 18088100
references.citation: J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):133-7
references.pmid: 18253881
references.citation: Tetrahedron Lett. 2008 Oct 27;49(44):6282-6285
references.pmid: 19865468
references.citation: J Ethnopharmacol. 2008 Oct 30;120(1):92-7
references.pmid: 18725281
references.citation: J Nat Prod. 2007 Oct;70(10):1593-600
references.pmid: 17910513
references.citation: Z Naturforsch C J Biosci. 2008 Sep-Oct;63(9-10):636-8
references.pmid: 19040098
references.citation: Bioorg Med Chem. 2008 Mar 15;16(6):2939-44
references.pmid: 18178092
references.citation: J Nat Prod. 2008 Mar;71(3):334-9
references.pmid: 18177008
references.citation: Anticancer Res. 2001 Jul-Aug;21(4A):2489-500
references.pmid: 11724312
references.citation: Bioorg Med Chem. 2007 Sep 1;15(17):5877-87
references.pmid: 17582775
references.citation: Org Lett. 2007 Apr 12;9(8):1525-8
references.pmid: 17373804
references.citation: Mar Drugs. 2007 Jun 25;5(2):40-51
references.pmid: 18463723