title: A multicomponent approach to the synthesis of 1,3-dicarbonylic compounds.
abstract: A general synthesis of 1,3-dicarbonylic compounds using multicomponent reactions of isocyanides is described. The process involves a Passerini three-component condensation of glyoxal derivatives, isocyanides and acetic acid, followed by metal mediated reductive or solvolytic removal of the acid component. Noteworthy, reductive deacetoxylation of Passerini glyoxylamide adducts was successfully achieved using photochemically activated SmI(2). This procedure constitutes a novel convenient method for the direct synthesis of malonic retro-peptidic subunits.
authors.affiliation: Laboratorio de Química Orgánica y Bioorgánica (L.O.B.O.), Departamento de Química Orgánica e Inorgánica, Facultad de Veterinaria, Universidad de Extremadura, 10071, Cáceres, Spain.
authors.forename: Ana G
authors.initials: AG
authors.lastname: Neo
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Carrillo
authors.forename: Jose
authors.initials: J
authors.lastname: Delgado
authors.forename: Stefano
authors.initials: S
authors.lastname: Marcaccini
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Marcos
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003998:Dicarboxylic Acids / Q000138:chemical synthesis*; D008314:Malonates / Q000138:chemical synthesis
chemical_list: D003998:Dicarboxylic Acids; D008314:Malonates; C008314:malonamide
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