Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection.
We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly higher than those in patients without pneumonia. This tendency was also present for IL-6, IL-8, IL-10, IL-13, and MCP-1 in patients with pneumonia. Among patients with pneumonia, the levels of MCP-1 were significantly higher in the group of patients with pneumonia with severe respiratory failure than patients with mild pneumonia.
Takano
T
T
Department of Pediatrics, Osaka General Medical Center, Sumiyoshi-ku, Osaka, Japan. takano@gh.opho.jp
Tajiri
H
H
Kashiwagi
Y
Y
Kimura
S
S
Kawashima
H
H
D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000150:complications / Q000276:immunology*; D008297:Male; D011014:Pneumonia / Q000276:immunology / Q000473:pathology
D016207:Cytokines
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