T cells that trigger acute experimental autoimmune encephalomyelitis also mediate subsequent disease relapses and predominantly produce IL-17.
Earlier studies showed that donor T cells that initiated a murine adoptive EAE persisted in the CNS of the recipients throughout the subsequent relapsing cycles. To clarify the functions of the persistent donor T cells in EAE relapsing disease, anti-Thy-1 antibodies were used to deplete these cells. Results showed that such treatment abrogated subsequent relapsing cycles in these animals. In addition, it was evident that a shift in cytokine profile occurred during acute and relapsing disease phases. These results unambiguously support the appropriateness of targeting T cells with specificity for the priming antigen in design of therapeutic approaches for MS.
Li
Jinzhu
J
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Zhao
Xiaoqing
X
Hao
Hui-Wen
HW
Shaw
Michael K
MK
Tse
Harley Y
HY
D019264:Adoptive Transfer; D000818:Animals; D002469:Cell Separation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism; D005434:Flow Cytometry; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology*; D051379:Mice; D012008:Recurrence; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D018800:Thy-1 Antigens / Q000276:immunology / Q000378:metabolism
D020381:Interleukin-17; D018800:Thy-1 Antigens
Nat Rev Immunol. 2002 Feb;2(2):85-95
11910899
Nature. 2003 Feb 13;421(6924):744-8
12610626
Curr Allergy Asthma Rep. 2003 Jan;3(1):86-93
12543000
Eur J Immunol. 1997 Nov;27(11):2927-34
9394820
J Neuroimmunol. 2005 Dec 30;170(1-2):105-14
16257061
J Immunol. 1998 Oct 15;161(8):4437-46
9780223
J Exp Med. 2008 Apr 14;205(4):799-810
18391061
J Exp Med. 1999 Apr 5;189(7):1033-42
10190894
J Autoimmun. 2000 Jun;14(4):278-82
10882053
J Immunol. 2000 Jan 15;164(2):670-8
10623809
Lab Invest. 1994 Nov;71(5):671-9
7526038
Mol Immunol. 2008 Feb;45(4):1191-6
17697713
Eur J Immunol. 1998 Dec;28(12):3893-903
9862326
J Exp Med. 1999 Apr 5;189(7):1021-4
10190892
J Exp Med. 1996 Apr 1;183(4):1777-88
8666934
Cell Immunol. 1985 Mar;91(1):240-54
2578895
J Neuroimmunol. 2007 Feb;183(1-2):96-103
17240458
Neurology. 1996 Apr;46(4):907-11
8780061
J Neurosci Res. 2007 Jun;85(8):1685-93
17465017
J Neuroimmunol. 1993 Jul;46(1-2):113-21
7689581
J Exp Med. 1995 Jul 1;182(1):75-85
7540658
J Neurosci Res. 1996 Sep 15;45(6):690-9
8892080
Nature. 1984 May 24-30;309(5966):356-8
6203039
J Immunol. 2009 Dec 1;183(11):7547-56
19890052
J Immunol. 2003 Feb 15;170(4):1690-8
12574332
J Neuroimmunol. 1993 Jul;46(1-2):129-36
7689583