title: Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection.
abstract: OBJECTIVE
  the aim of this study was to evaluate a link between mesh infection and shrinkage.
  
  
  METHODS
  twenty-eight Wistar rats were implanted with synthetic meshes that were either non-absorbable (polypropylene (PP), n = 14) or absorbable (poly (D: ,L: -lactic acid) (PLA94), n = 14). A validated animal incisionnal abdominal hernia model of mesh infection was used. Fourteen meshes (n = 7 PLA94 and n = 7 PP meshes) were infected intraoperatively with 10e6 CFU Escherichia coli, and compared with 14 non-infected meshes (n = 7 PLA94 and n = 7 PP meshes) (control groups). Explantations were performed on day 30. Shrinkage was evaluated by a reproducible numerical analysis of mesh area. Infection and histological study were evaluated on day 30.
  
  
  RESULTS
  non-infected meshes were less shrunk than infected meshes for both non-absorbable (5.0 ± 1.7% versus 21.6 ± 6.1%, p < 0.05) and absorbable meshes (2.4 ± 0.9% versus 11.0 ± 2.5%, p < 0.05).
  
  
  CONCLUSIONS
  this study highlights a link between infection and shrinkage in the model used.
authors.affiliation: Department of Obstetrics and Gynecology, Carémeau Hospital, Nîmes, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Mamy
authors.forename: Vincent
authors.initials: V
authors.lastname: Letouzey
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lavigne
authors.forename: Xavier
authors.initials: X
authors.lastname: Garric
authors.forename: Jean
authors.initials: J
authors.lastname: Gondry
authors.forename: Pierre
authors.initials: P
authors.lastname: Mares
authors.forename: Renaud
authors.initials: R
authors.lastname: de Tayrac
mesh_terms: D000818:Animals; D004868:Equipment Failure; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000150:complications; D005260:Female; D046449:Hernia, Abdominal / Q000601:surgery*; D019344:Lactic Acid / Q000009:adverse effects*; D023421:Models, Animal; D011091:Polyesters; D011108:Polymers / Q000009:adverse effects*; D011126:Polypropylenes / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D013314:Stress, Mechanical; D013526:Surgical Mesh / Q000009:adverse effects* / Q000382:microbiology*
chemical_list: D011091:Polyesters; D011108:Polymers; D011126:Polypropylenes; D019344:Lactic Acid; C033616:poly(lactide)
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