Our clinical experience about prenatal diagnosis and neonatal outcomes of fetal central nervous system anomalies.
OBJECTIVE
To present a retrospective analysis of the prenatal diagnosis and the outcome of fetuses diagnosed with central nervous system (CNS) anomalies.


METHODS
We reviewed the medical records and ultrasound data of 69 cases diagnosed with CNS anomalies from 2007 to 2008. We described the prenatal diagnosis, associated findings, and outcome of these patients.


RESULTS
Sixty-nine patients were diagnosed with CNS anomalies. Of these, 31 had ventriculomegaly + hydrocephaly, 14 had spina bifida + meningomyelosel, 5 had choroid plexus cyst, 5 had Dandy Walker malformation, 3 had sacrocoxigeal teratoma, 2 had encephalosel, 1 had microcephaly, and 1 had Arnold Chiari malformation. Eight amniocentesis, three cord blood sampling, and two fetal reduction procedure were performed. Nine pregnancy termination and 36 delivery were performed. Neurosurgical correction was performed for neonates with spina bifida, hydrocephaly and sacrocoxigeal teratoma. Twenty-one neonates were discharged with cure, 4 neonates with follow-up, 7 neonates with paraplegia, and 13 neonates died.


CONCLUSIONS
The outcome of fetuses with CNS anomalies was shown to depend mainly on the degree of neural tube defect and the associated anomalies were the most important factors in surviving.
Ozkan
Zehra Sema
ZS
Department of Obstetric and Gynecology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. zehrasema@yahoo.com
Gilgin
Hasan
H
Aygün
Hatice Banu
HB
Deveci
Derya
D
Simşek
Mehmet
M
Kumru
Selahattin
S
Yüce
Hüseyin
H
D000293:Adolescent; D000328:Adult; D002490:Central Nervous System / Q000002:abnormalities* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000209:etiology; D009421:Nervous System Malformations / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000401:mortality; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D055815:Young Adult