Synthesis of highly fluorinated 2,2'-biphenols and 2,2'-bisanisoles.
Multiply fluorine-substituted iodo anisoles are efficiently coupled in an Ullmann-type reaction to provide the corresponding bisanisoles. The coupling is selective and even tolerates bromo moieties. Subsequent deprotection of hydroxy groups gives access to highly fluorinated biphenols.
Francke
Robert
R
Kekulé Institute for Organic Chemistry and Biochemistry, Bonn University, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
Schnakenburg
Gregor
G
Waldvogel
Siegfried R
SR