Maltose, a promising osmotic agent in peritoneal dialysis solution.
Peritoneal dialysis has undergone considerable development from a technological point of view, and osmotic agent has played the essential role in peritoneal dialysis fluid. Because the most commonly used osmotic agent is glucose and icodextrin, there are some disadvantages related to the use of glucose-based solutions and icodextrin. So it is urgent to develop a new peritoneal dialysis osmotic agent. According to these characteristics of glucose and icodextrin, it is promising to explore a better osmotic agent of peritoneal dialysis solution which is able to allow maintenance of the maximum ultrafiltration gradient, and prevent toxicity or accumulation of unwanted substances in the blood, being non-toxic or less-toxic, furthermore the metabolite should not cause significant metabolic disturbance. Maltose may be one of promising osmotic agent and may put an important influence on development of peritoneal dialysis.
Shu
Zhan-Jun
ZJ
Department of Nephrology & Renal Institute, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Peng
You-Ming
YM
Sun
Lin
L
Xiao
Li
L
Liu
Ying-hong
YH
Li
Jun
J
Ling
Guang-hui
GH
Tang
Wen-bin
WB
Halmurat
Upur
U
Liu
Fu-you
FY
D015314:Dialysis Solutions / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008320:Maltose / Q000494:pharmacology / Q000627:therapeutic use*; D009995:Osmosis / Q000187:drug effects; D010530:Peritoneal Dialysis / Q000379:methods*
D015314:Dialysis Solutions; D008320:Maltose