title: Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk - a meta-analysis.
abstract: A number of studies have evaluated two functional polymorphisms on p53 Arg72Pro and GSTP1 Ile105Val, in relation to esophageal cancer susceptibility. However, the results remain conflicting rather than conclusive. This meta-analysis on 2919 cases and 4074 controls for p53 Arg72Pro and 1885 cases and 2194 controls for GSTP1 Ile105Val from 13 published case-control studies showed that no significant general main effects for GSTP1 Ile105Val on esophageal cancer risk. However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity. In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, may contribute to esophageal cancer development, especially in Asian. Additional well-designed large studies were required for the validation of this association.
authors.affiliation: Department of Laboratory, The 82th Hospital of the People's Liberation Army, Huaian,China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhao
authors.forename: Furu
authors.initials: F
authors.lastname: Wang
authors.forename: Shunlin
authors.initials: S
authors.lastname: Shan
authors.forename: Yiqi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xueming
authors.initials: X
authors.lastname: Qiu
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Jiao
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.forename: Yunxiang
authors.initials: Y
authors.lastname: Du
mesh_terms: D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D015201:Meta-Analysis as Topic; D011110:Polymorphism, Genetic / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
references.citation: Head Neck. 2002 Jun;24(6):575-81
references.pmid: 12112555
references.citation: Mutat Res. 2004 Nov;567(2-3):447-74
references.pmid: 15572290
references.citation: Int J Cancer. 1994 Apr 1;57(1):38-46
references.pmid: 8150539
references.citation: Carcinogenesis. 1998 Mar;19(3):433-6
references.pmid: 9525277
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Eur J Gastroenterol Hepatol. 2003 Jan;15(1):41-7
references.pmid: 12544693
references.citation: Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Feb;19(1):10-3
references.pmid: 11836677
references.citation: Cancer Genet Cytogenet. 2005 Jul 15;160(2):160-3
references.pmid: 15993272
references.citation: Science. 1991 Jul 5;253(5015):49-53
references.pmid: 1905840
references.citation: Nat Rev Cancer. 2001 Dec;1(3):233-40
references.pmid: 11902578
references.citation: Jpn J Cancer Res. 1999 Jan;90(1):81-5
references.pmid: 10076569
references.citation: Science. 1990 Nov 30;250(4985):1233-8
references.pmid: 1978757
references.citation: Nature. 1992 Mar 19;356(6366):215-21
references.pmid: 1552940
references.citation: Cancer Res. 2009 Apr 1;69(7):2956-65
references.pmid: 19339270
references.citation: Cancer Detect Prev. 2003;27(2):139-46
references.pmid: 12670526
references.citation: Int J Cancer. 1994 Jul 15;58(2):192-6
references.pmid: 8026880
references.citation: Int J Cancer. 1993 Jul 9;54(5):713-9
references.pmid: 8325701
references.citation: J Natl Cancer Inst. 2003 Sep 17;95(18):1404-13
references.pmid: 13130116
references.citation: Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1480-4
references.pmid: 8108434
references.citation: Mol Carcinog. 2008 Feb;47(2):100-4
references.pmid: 17918207
references.citation: Cancer Detect Prev. 2006;30(5):423-31
references.pmid: 17064856
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):294-300
references.pmid: 16492918
references.citation: Cancer Res. 1999 Feb 1;59(3):586-9
references.pmid: 9973204
references.citation: Dis Esophagus. 2010 Jan;23(1):36-9
references.pmid: 19302219
references.citation: Int J Cancer. 2007 Oct 15;121(8):1643-58
references.pmid: 17674367
references.citation: Int J Cancer. 2000 Sep 20;89(5):458-64
references.pmid: 11008209
references.citation: Mol Cell Biol. 1999 Feb;19(2):1092-100
references.pmid: 9891044
references.citation: Int J Cancer. 2000 Jun 1;86(5):626-31
references.pmid: 10797282
references.citation: Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):1013-8
references.pmid: 9829710
references.citation: Mol Cell Biol. 1987 Feb;7(2):961-3
references.pmid: 3547088
references.citation: Oncol Rep. 2003 Sep-Oct;10(5):1615-23
references.pmid: 12883749
references.citation: Clin Cancer Res. 2005 Jul 1;11(13):4749-53
references.pmid: 16000570
references.citation: Mol Carcinog. 1999 Feb;24(2):128-36
references.pmid: 10078940
references.citation: Cancer Causes Control. 2004 Dec;15(10):1077-83
references.pmid: 15801491
references.citation: Cancer Genet Cytogenet. 2003 Jan 1;140(1):23-30
references.pmid: 12550754
references.citation: Carcinogenesis. 2007 Jun;28(6):1323-8
references.pmid: 17277236
references.citation: Oncol Rep. 2004 May;11(5):1115-20
references.pmid: 15069555
references.citation: Surg Today. 2005;35(1):7-18
references.pmid: 15622457
references.citation: Biochem Biophys Res Commun. 1997 Sep 18;238(2):397-402
references.pmid: 9299520
references.citation: Cancer Res. 2005 Oct 15;65(20):9582-7
references.pmid: 16230424
references.citation: Int J Cancer. 1998 Oct 23;79(5):517-20
references.pmid: 9761122
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Jun;9(6):551-6
references.pmid: 10868687
references.citation: Eur J Biochem. 1994 Sep 15;224(3):893-9
references.pmid: 7925413
references.citation: Br J Cancer. 1993 Jun;67(6):1413-7
references.pmid: 8512826
references.citation: Cancer Res. 1992 Nov 1;52(21):6092-7
references.pmid: 1394236
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):11-22
references.pmid: 14744727
references.citation: Cell. 1997 Jan 24;88(2):243-51
references.pmid: 9008165
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Aug;9(8):827-33
references.pmid: 10952100