The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control.
Age-related macular degeneration is the most common cause of blindness in the UK. Cellular replacement of retinal pigment epithelium cells is a potential therapeutic option to treat the cellular loss and dysfunction which is characteristic of age-related macular degeneration and other progressive retinopathies. A supportive scaffold, natural or artificial, may be required to facilitate cell delivery to the eye. Research to improve the biomimetic properties of such scaffolds, in order to optimise cell attachment and functionality following implantation, is ongoing. This short review will focus on the potential of biomaterials for ocular tissue engineering and how surface modification and the physical properties of these scaffolds can be tailored to help realise the full clinical potential of retinal pigment epithelium cell transplantation.
Treharne
Andrew J
AJ
School of Chemistry, University of Southampton, UK.
Grossel
Martin C
MC
Lotery
Andrew J
AJ
Thomson
Heather A
HA
D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology / Q000601:surgery*; D011108:Polymers / Q000737:chemistry; D055213:Retinal Pigment Epithelium / Q000637:transplantation*; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*; D006113:United Kingdom
D001672:Biocompatible Materials; D011108:Polymers