Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses.
The development of novel immune adjuvants is emerging as a significant area of vaccine delivery based on the continued necessity to amplify immune responses to a wide array of new antigens that are poorly immunogenic. This article specifically focuses on the application of nanoparticles and microparticles as vaccine adjuvants. Many investigators are in agreement that the size of the particles is crucial to their adjuvant activities. However, reports on correlating the size of particle-based adjuvants and the resultant immune responses have been conflicting, with investigators on both sides of the fence with impressive data in support of the effectiveness of particles with small sizes (submicron) over those with larger sizes (micron) and vice versa, while other investigators reported data that showed submicron- and micron-sized particles are effective to the same degree as immune adjuvants. We have generated a list of biological, immunological and, more importantly, vaccine formulation parameters that may have contributed to the inconsistency from different studies and made recommendations on future studies attempting to correlate the size of particulate adjuvants and the immune responses induced. The information gathered could lead to strategies to optimize the performance of nano-microparticles as immune adjuvants.
Oyewumi
Moses O
MO
Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA. moyewumi@neoucom.edu
Kumar
Amit
A
Cui
Zhengrong
Z
D056704:Adaptive Immunity; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008863:Microspheres; D053758:Nanoparticles; D010316:Particle Size; D014612:Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D014612:Vaccines
Pharm Res. 2008 Mar;25(3):551-62
17912489
J Pharm Pharmacol. 2006 Jun;58(6):717-28
16734973
J Control Release. 2000 Jul 3;67(2-3):347-56
10825566
J Pharm Pharmacol. 2005 Jun;57(6):699-707
15969924
Adv Drug Deliv Rev. 2003 Feb 24;55(3):329-47
12628320
Pharm Res. 2001 May;18(5):709-12
11465430
J Biomed Mater Res. 2002 Jun 5;60(3):480-6
11920673
Curr Opin Immunol. 2000 Aug;12(4):456-63
10899018
Int J Pharm. 2002 Feb 21;233(1-2):239-52
11897428
Int J Pharm. 2005 Aug 11;299(1-2):155-66
15998569
Vaccine. 2004 Jun 23;22(19):2406-12
15193402
Pharm Res. 2004 Apr;21(4):671-4
15139524
Vaccine. 2000 Dec 8;19(9-10):1047-54
11137238
J Control Release. 2005 Feb 2;102(2):313-32
15653154
Vaccine. 2009 Jun 2;27(27):3643-9
19464545
J Aerosol Med. 2004 Summer;17(2):174-85
15294069
Int J Pharm. 2009 Sep 8;379(1):41-50
19524654
Drug Discov Today. 2008 Oct;13(19-20):882-7
18656548
Int J Pharm. 2008 Apr 2;353(1-2):131-8
18162346
J Immunol. 1997 Mar 15;158(6):2723-30
9058806
J Pharm Sci. 2006 Dec;95(12):2738-50
16927245
Am J Med. 2005 Oct;118 Suppl 10A:7S-15S
16271535
Int J Pharm. 2008 Dec 8;364(2):265-71
18662761
Pharm Res. 2003 Feb;20(2):212-20
12636159
Immunol Rev. 1997 Apr;156:199-209
9176709
Pharm Res. 2001 Mar;18(3):352-60
11442276
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8578-83
8710913
Methods. 2006 Sep;40(1):1-9
16997708
Biomaterials. 2009 Feb;30(5):879-91
19027152
J Control Release. 2010 Apr 19;143(2):207-14
20074597
Expert Rev Vaccines. 2003 Apr;2(2):269-83
12899577
Cancer Res. 1993 Aug 15;53(16):3765-70
8339289
Biotechnol Prog. 2008 Jul-Aug;24(4):807-14
19194892
J Anat. 1996 Dec;189 ( Pt 3):503-5
8982823
Vaccine. 2003 Feb 14;21(9-10):883-90
12547598
J Pharm Sci. 2009 Mar;98(3):812-43
18661544
J Pharm Sci. 1986 Apr;75(4):361-4
3723356
Int J Pharm. 2006 Mar 27;311(1-2):203-8
16413708
Methods. 2006 Sep;40(1):30-8
16997711
Bioconjug Chem. 1998 Jul-Aug;9(4):418-50
9667945
Vaccine. 1996 Oct;14(15):1442-50
8994320
Nat Rev Immunol. 2006 Feb;6(2):148-58
16491139
J Control Release. 2002 May 17;81(1-2):173-84
11992690
J Microencapsul. 1998 Jan-Feb;15(1):107-19
9463812
Vaccine. 2008 May 23;26(22):2680-8
18430493
Expert Rev Vaccines. 2009 May;8(5):547-57
19397412
Vaccine. 1996 Sep;14(13):1251-6
8961514
Vaccine. 1996 Nov;14(16):1523-30
9014294
Vaccine. 1996 Dec;14(17-18):1677-85
9032899
Biomacromolecules. 2005 May-Jun;6(3):1375-9
15877355
J Control Release. 1998 Dec 4;56(1-3):63-73
9801430
J Microencapsul. 2004 Dec;21(8):829-39
15799539
Trends Immunol. 2009 Jan;30(1):23-32
19059004
Nat Biotechnol. 2007 Oct;25(10):1159-64
17873867
J Immunol. 2004 Nov 15;173(10):6143-50
15528351
Eur J Pharm Biopharm. 2003 Jan;55(1):115-24
12551712
Biomacromolecules. 2009 Mar 9;10(3):651-7
19203184
Curr Drug Deliv. 2008 Oct;5(4):230-42
18855591
Eur J Pharm Sci. 2009 Nov 5;38(4):362-9
19733658
Biomaterials. 2007 Dec;28(35):5344-57
17825905
Int J Pharm. 2010 Jun 30;393(1-2):197-202
20416366
J Virol. 2001 Oct;75(19):9037-43
11533167
Hum Vaccin. 2008 Jan-Feb;4(1):44-9
18438105
Curr Opin Microbiol. 2010 Feb;13(1):106-12
20079678
Int J Pharm. 2005 Mar 3;291(1-2):79-86
15707734
Mol Pharm. 2007 Jan-Feb;4(1):73-84
17274665
J Control Release. 2001 Sep 11;76(1-2):149-68
11532321
Crit Rev Ther Drug Carrier Syst. 1995;12(1):1-99
8521523
Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):518-31
19941919
J Control Release. 2006 May 1;112(1):26-34
16529839
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):811-6
10639162
Pharm Res. 2002 Feb;19(2):132-9
11883639
Nat Rev Drug Discov. 2003 Sep;2(9):727-35
12951579
Pharm Res. 2002 Jul;19(7):939-46
12180545
Int J Pharm. 2005 Sep 14;301(1-2):149-60
16023313
Pharm Res. 1998 Feb;15(2):270-5
9523314
Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):378-93
19922750
Immunol Cell Biol. 2004 Oct;82(5):488-96
15479434
Vaccine. 2008 Feb 26;26(9):1214-27
18243435
Vaccine. 2002 Nov 22;21(1-2):67-77
12443664
Adv Drug Deliv Rev. 2001 Apr 25;47(2-3):165-96
11311991
Biologicals. 2009 Jun;37(3):141-7
19285425
Biomaterials. 1997 Feb;18(4):327-35
9068895
Adv Drug Deliv Rev. 1998 Dec 1;34(2-3):305-320
10837683
Vaccine. 2007 May 10;25(19):3752-62
17336431
Int J Pharm. 2008 Dec 8;364(2):272-80
18555624
Biomacromolecules. 2005 Sep-Oct;6(5):2590-600
16153096
Adv Drug Deliv Rev. 2008 May 22;60(8):915-28
18325628
Methods. 2006 Sep;40(1):20-9
16997710
J Immunol. 2004 Sep 1;173(5):3148-54
15322175
J Control Release. 2010 Jan 4;141(1):93-100
19729045
J Immunol Methods. 2009 Aug 31;348(1-2):1-8
19545572
J Control Release. 2010 Jun 1;144(2):118-26
20156497
Eur J Immunol. 2008 May;38(5):1404-13
18389478
Vaccine. 2005 Dec 1;23(48-49):5599-617
16099080
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5
19139407
Trends Biotechnol. 2000 May;18(5):203-11
10758515
Vaccine. 2003 Mar 7;21(11-12):1250-5
12559806
Expert Rev Vaccines. 2007 Jun;6(3):391-400
17542754
Int J Pharm. 2005 Jul 25;298(2):315-22
15961266