[Wound healing potential of chitosan and its N-sulfosuccinoyl derivatives].
Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control.
Alekseeva
T P
TP
Rakhmetova
A A
AA
Bogoslovskaia
O A
OA
Ol'khovskaia
I P
IP
Levov
A N
AN
Il'ina
A V
AV
Varlamov
V P
VP
Baĭtukalov
T A
TA
Glushchenko
N N
NN
D000818:Animals; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005782:Gels; D051379:Mice; D012867:Skin / Q000187:drug effects* / Q000293:injuries; D013329:Structure-Activity Relationship; D013386:Succinates / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D005782:Gels; D013386:Succinates; D048271:Chitosan; C024599:thiosuccinic acid