title: Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis.
abstract: OBJECTIVE
  To determine which brain regions are relevant to deterioration in abstract reasoning as measured by Raven's Colored Progressive Matrices (CPM) in the context of dementia.
  
  
  METHODS
  MR images of 37 consecutive patients including 19 with Alzheimer's disease (AD) and 18 with amnestic mild cognitive impairment (aMCI) were retrospectively analyzed. All patients were administered the CPM. Regional grey matter (GM) volume was evaluated according to the regimens of voxel-based morphometry, during which a non-linear registration algorithm called Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra was employed. Multiple regression analyses were used to map the regions where GM volumes were correlated with CPM scores.
  
  
  RESULTS
  The strongest correlation with CPM scores was seen in the left middle frontal gyrus while a region with the largest volume was identified in the left superior temporal gyrus. Significant correlations were seen in 14 additional regions in the bilateral cerebral hemispheres and right cerebellum.
  
  
  CONCLUSIONS
  Deterioration of abstract reasoning ability in AD and aMCI measured by CPM is related to GM loss in multiple regions, which is in close agreement with the results of previous activation studies.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. tyoshiu@radiol.med.kyushu-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.forename: Akio
authors.initials: A
authors.lastname: Hiwatashi
authors.forename: Koji
authors.initials: K
authors.lastname: Yamashita
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ohyagi
authors.forename: Akira
authors.initials: A
authors.lastname: Monji
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Takayama
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kamano
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kawashima
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kira
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis*; D003704:Dementia / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
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