title: MT1-MMP and integrins: Hand-to-hand in cell communication.
abstract: Integrins are transmembrane adhesion receptors essential for cell communication with the environment and in particular with the extracellular matrix (ECM). ECM components can be processed by several enzymes; one of the largest families involved in this task being matrix metalloproteinases (MMPs). MT1-MMP (membrane type 1-matrix metalloproteinase) is a membrane-anchored MMP with important roles in processes such as tissue development, tumor invasion, and angiogenesis. In addition to its catalytic-dependent functions, MT1-MMP can interact, via its cytosolic tail, with intracellular components, and trigger signaling pathways that impact cell decisions. These features make MT1-MMP similar to integrins, because both are able to integrate events in the extracellular and intracellular milieus. Accordingly, it is probably no coincidence that MT1-MMP often associates and functionally cooperates with distinct integrins at specific cellular compartments. In this review, we discuss aspects of the molecular and functional interplay between MT1-MMP and integrins in distinct cellular and biological contexts.
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Gonzalo
authors.forename: Vanessa
authors.initials: V
authors.lastname: Moreno
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: Gálvez
authors.forename: Alicia G
authors.initials: AG
authors.lastname: Arroyo
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002450:Cell Communication; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D016023:Integrins; D053511:Matrix Metalloproteinase 14