Parametric imaging of cancer with optical coherence tomography.
We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images.
McLaughlin
Robert A
RA
University of Western Australia, School of Electrical, Electronic and Computer Engineering, Crawley, West Australia, Australia. robertm@ee.uwa.edu.au
Scolaro
Loretta
L
Robbins
Peter
P
Saunders
Christobel
C
Jacques
Steven L
SL
Sampson
David D
DD
D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014407:Tumor Cells, Cultured