The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule?
She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.
Trcek
Tatjana
T
Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Singer
Robert H
RH
D000818:Animals; D002454:Cell Differentiation; D003593:Cytoplasm / Q000378:metabolism*; D004330:Drosophila / Q000166:cytology / Q000196:embryology; D011485:Protein Binding; D014176:Protein Biosynthesis; D021381:Protein Transport; D012319:RNA Polymerase II / Q000378:metabolism; D020871:RNA Stability; D034443:RNA Transport; D012261:Ribonucleoproteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D014158:Transcription, Genetic
D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D012319:RNA Polymerase II
Cell. 2009 Feb 20;136(4):719-30
19239891
EMBO J. 2000 Dec 1;19(23):6592-601
11101531
J Biol Chem. 2001 Apr 20;276(16):12959-66
11278368
Genes Dev. 2003 Jun 1;17(11):1402-14
12782658
Mol Biol Cell. 2009 Apr;20(8):2265-75
19244342
Mol Cell Biol. 2007 Dec;27(23):8340-51
17893325
Nat Struct Mol Biol. 2007 Sep;14(9):796-806
17676063
Genes Dev. 2000 Oct 15;14(20):2635-49
11040217
Genes Dev. 2008 Apr 15;22(8):1037-50
18413716
Trends Cell Biol. 2002 Oct;12(10):466-72
12441250
Curr Biol. 1999 Mar 25;9(6):333-6
10209102
Curr Opin Cell Biol. 1992 Dec;4(6):975-8
1485968
Science. 1997 Jul 18;277(5324):383-7
9219698
Science. 2009 Nov 27;326(5957):1212-6
19965463
EMBO Rep. 2008 Aug;9(8):781-7
18566598
Genes Dev. 2008 Aug 1;22(15):2022-7
18676807
Mol Cell Biol. 2005 Jun;25(11):4752-66
15899876
Curr Biol. 2003 Feb 4;13(3):199-207
12573215
J Cell Biol. 2003 Jan 6;160(1):77-87
12507992
Genes Dev. 2010 Sep 1;24(17):1914-26
20713510
Nature. 2003 Oct 16;425(6959):737-41
14562106
Genes Dev. 1998 Feb 1;12(3):357-69
9450930
Cell. 1996 Mar 8;84(5):687-97
8625407
Cell. 2007 Oct 5;131(1):174-87
17923096
J Biol Chem. 2002 May 31;277(22):19639-48
11893740
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7045-50
11416185
Cell. 2009 May 15;137(4):708-20
19450518
Nature. 2004 Apr 29;428(6986):959-63
15118729