SnoN in mammalian development, function and diseases.
SnoN (Ski-novel protein) was discovered as a nuclear proto-oncogene on the basis of its ability to induce transformation of chicken and quail embryonic fibroblasts. As a crucial negative regulator of transforming growth factor-β (TGF-β) signaling and also an activator of p53, it plays an important role in regulating cell proliferation, senescence, apoptosis, and differentiation. Recent studies of its expression patterns and functions in mouse models and mammalian cells have revealed important functions of SnoN in normal epithelial development and tumorigenesis. Evidence suggests that SnoN has both pro-oncogenic and anti-oncogenic functions by modulating multiple signaling pathways. These studies suggest that SnoN may have broad functions in the development and homeostasis of embryonic and postnatal tissues.
Jahchan
Nadine S
NS
Department of Molecular and Cell Biology, University of California, Berkeley, USA.
Luo
Kunxin
K
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D047108:Embryonic Development; D005260:Female; D005786:Gene Expression Regulation; D016158:Genes, p53; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D058990:Molecular Targeted Therapy; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D011519:Proto-Oncogenes; D015398:Signal Transduction / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C060615:SKIL protein, human; D015534:Trans-Activators; D016212:Transforming Growth Factor beta
J Biol Chem. 2007 Mar 2;282(9):6517-24
17202138
J Biol Chem. 2007 Mar 30;282(13):9475-9481
17276978
Oncogene. 1993 Feb;8(2):457-66
8426750
Cancer Res. 2005 Mar 15;65(6):2296-302
15781643
Nucleic Acids Res. 1989 Jul 25;17(14):5489-500
2762147
FEBS Lett. 1996 Nov 18;397(2-3):253-9
8955358
Nucleic Acids Res. 1997 Jul 15;25(14):2930-7
9207045
J Biol Chem. 2003 Aug 15;278(33):30540-7
12764135
BMC Cancer. 2006 Oct 24;6:252
17062133
Int J Dermatol. 2009 Jun;48(6):579-83
19538364
Cytokine Growth Factor Rev. 2001 Mar;12(1):1-8
11312113
J Biol Chem. 2005 Apr 1;280(13):13037-46
15677458
EMBO J. 2000 May 15;19(10):2280-91
10811619
Dev Dyn. 1996 Feb;205(2):114-25
8834472
Annu Rev Cell Dev Biol. 2005;21:659-93
16212511
Genes Dev. 2005 Dec 1;19(23):2783-810
16322555
J Am Soc Nephrol. 2006 Oct;17(10):2781-91
16959829
J Biol Chem. 2008 May 9;283(19):13269-79
18334480
Science. 1999 Oct 22;286(5440):771-4
10531062
Hum Pathol. 2008 Mar;39(3):403-9
18261624
J Virol. 1991 Sep;65(9):4929-35
1870207
Mol Cell Biol. 2007 Jan;27(1):324-39
17074815
Blood. 1995 Sep 15;86(6):2146-55
7662963
J Neurosci. 2009 Apr 1;29(13):4312-21
19339625
Kidney Int. 2006 May;69(10):1733-40
16625151
Nat Rev Cancer. 2006 Jul;6(7):506-20
16794634
J Biol Chem. 2006 Nov 3;281(44):33008-18
16966324
Nucleic Acids Res. 1993 Sep 25;21(19):4632-8
8233802
Mol Cell Biol. 2003 Aug;23(15):5446-59
12861029
J Biol Chem. 2009 Oct 23;284(43):29988-96
19717568
Lab Invest. 2005 Nov;85(11):1330-41
16200078
Cell Res. 2009 Jan;19(1):47-57
19114989
Am J Pathol. 2003 Oct;163(4):1539-49
14507660
Mol Cell Biol. 2005 Dec;25(24):10731-44
16314499
Curr Opin Genet Dev. 2004 Feb;14(1):65-70
15108807
Nat Genet. 2002 Jan;30(1):106-9
11731796
J Biol Chem. 2010 Jul 16;285(29):21969-77
20457602
Neuron. 2006 May 4;50(3):389-400
16675394
J Biol Chem. 2002 Aug 9;277(32):28483-90
12023281
EMBO J. 2009 Nov 18;28(22):3500-13
19745809
Cancer Res. 2010 May 15;70(10):4204-13
20460516
Cell. 1989 Oct 20;59(2):293-303
2553267
Genes Dev. 1997 Aug 15;11(16):2029-39
9284043
Am J Pathol. 2010 Mar;176(3):1139-47
20093492
Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12437-42
16109768
Mol Cell Neurosci. 2007 Apr;34(4):603-11
17292623
J Biol Chem. 2010 Feb 5;285(6):3633-3642
19966340