Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: a clinical study and review of the literature.
Translocation (10;17)(p13-15;q12-21) in acute leukemia is rarely reported in the literature. Here, we present both a novel t(10;17) case study and a review of relevant literature on t(10;17) in acute leukemia (10 cases). In summary, we came to the following preliminary conclusions: t(10;17) is associated with poorly differentiated acute leukemia subtype [90%; eight cases of acute myeloid leukemia (AML M0, M1) and one case of acute undifferentiated leukemia], phagocytic activity by blasts occurs (30%), and the survival time was short in three of the seven t(10;17) cases for whom follow-up data were available (median, 8 months). More clinical studies concerning the prognosis, treatment response, and survival of patients with t(10;17) are necessary.
Oh
Seung Hwan
SH
Department of Laboratory Medicine, Inje University College of Medicine, Gaegeum-dong, Busanjin-gu, Busan, Korea.
Park
Tae Sung
TS
Cho
Sun Young
SY
Kim
Min Jin
MJ
Huh
Jungwon
J
Kim
Bomi
B
Song
Sae Am
SA
Lee
Ja Young
JY
Jun
Kyung Ran
KR
Shin
Jeong Hwan
JH
Kim
Hye Ran
HR
Lee
Jeong Nyeo
JN
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001752:Blast Crisis / Q000473:pathology; D002648:Child; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002886:Chromosomes, Human, Pair 17; D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism; D010586:Phagocytes / Q000473:pathology; D014178:Translocation, Genetic
D015703:Antigens, CD; D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D009195:Peroxidase; D003630:Daunorubicin