Adaptive immunity and adipose tissue biology.
Studies of immunity typically focus on understanding how hematopoietic cells interact within conventional secondary lymphoid tissues. However, immune reactions and their regulation occur in various environments within the body. Adipose tissue is one tissue that can influence and be influenced by adjacent and embedded lymphocytes. Despite the abundance and wide distribution of such tissue, and despite a growing obesity epidemic, studies of these interactions have been only marginally appreciated in the past. Here, we review advances in understanding of lymphoid structures within adipose tissue, the relationship between adipose tissue and adaptive immune function, and evidence for how this relationship contributes to obesity-associated diseases.
Kaminski
Denise A
DA
Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Randall
Troy D
TD
D056704:Adaptive Immunity; D000273:Adipose Tissue / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
Nat Rev Immunol. 2008 Jul;8(7):523-32
18566595
Science. 1994 Apr 29;264(5159):703-7
8171322
Am Heart J. 2007 Jun;153(6):907-17
17540190
Science. 1995 Jul 28;269(5223):543-6
7624777
Cell Tissue Res. 2002 Dec;310(3):321-30
12457231
Aliment Pharmacol Ther. 2006 Jun 1;23(11):1511-23
16696799
Am J Pathol. 2006 Nov;169(5):1739-52
17071597
Clin Immunol. 2002 Oct;105(1):81-92
12483997
Trends Immunol. 2001 Feb;22(2):83-7
11286708
Eur J Immunol. 2009 Jul;39(7):1893-901
19585513
Nature. 2010 Apr 29;464(7293):1367-70
20200518
Annu Rev Immunol. 2008;26:627-50
18370924
Nat Med. 2009 Aug;15(8):930-9
19633656
Mol Cell. 1998 Aug;2(2):275-81
9734366
Springer Semin Immunopathol. 2005 Mar;26(4):385-404
15609021
Nature. 2010 Apr 29;464(7293):1362-6
20200520
Dev Immunol. 1991;1(3):203-12
1821697
Curr Opin Immunol. 2001 Apr;13(2):195-201
11228413
J Immunol. 2009 Jul 15;183(2):1155-65
19553538
J Clin Invest. 2000 Jun;105(12):1683-5
10862783
Cardiovasc Res. 2008 Dec 1;80(3):463-70
18694873
Immunity. 2002 Jan;16(1):67-76
11825566
J Immunol. 2010 Mar 15;184(6):3127-33
20173021
J Immunol. 2002 Feb 1;168(3):986-90
11801629
J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7
17374712
Nature. 1997 Oct 9;389(6651):610-4
9335502
Nat Med. 2006 Feb;12(2):178-80
16462800
Curr Opin Clin Nutr Metab Care. 2004 Nov;7(6):629-33
15534430
Int Immunol. 1991 Jun;3(6):543-50
1679664
Eur J Immunol. 2009 Sep;39(9):2629-35
19662632
J Immunol. 2009 Apr 1;182(7):3945-6
19299688
Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1892-8
12426221
Nat Med. 2009 Aug;15(8):914-20
19633658
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2152-6
6609359
N Engl J Med. 2007 Jan 18;356(3):213-5
17229948
Immunity. 2005 Jul;23(1):1-2
16039572
J Clin Endocrinol Metab. 1997 Oct;82(10):3408-13
9329377
Blood. 2007 May 1;109(9):3749-56
17234743
Anat Rec. 1995 Feb;241(2):163-74
7710133
Nat Rev Immunol. 2004 May;4(5):371-9
15122202
Eur J Endocrinol. 2006 May;154(5):691-7
16645016
J Clin Invest. 1997 Dec 1;100(11):2777-82
9389742
Diabetes Metab. 2008 Dec;34(6 Pt 2):658-63
19195627
J Clin Invest. 2004 Aug;114(3):427-37
15286809
Clin Exp Immunol. 2008 Jan;151(1):130-8
17991290
J Nutr. 2007 May;137(5):1236-43
17449587
Immunity. 2009 May;30(5):731-43
19427241
J Reticuloendothel Soc. 1980 Dec;28(6):585-99
6450834
Obes Rev. 2010 Jan;11(1):11-8
19656312
J Lipid Res. 1972 Jan;13(1):2-11
5059196
J Autoimmun. 2008 Nov;31(3):252-6
18502610
Immunity. 2007 Feb;26(2):241-55
17307705
Science. 1993 Jan 1;259(5091):87-91
7678183
Nature. 2010 Jan 28;463(7280):540-4
20023630
Trends Immunol. 2010 Jun;31(6):228-35
20434953
Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1262-8
19240255
Cell Physiol Biochem. 2008;22(5-6):531-8
19088435
J Exp Med. 2006 Oct 30;203(11):2541-50
17060475
J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S31-6
18987268
J Exp Med. 1992 Feb 1;175(2):397-404
1370683
World J Gastroenterol. 2000 Apr;6(2):169-176
11819552
Nat Med. 2009 Aug;15(8):921-9
19633657
Immunity. 2006 Jan;24(1):19-28
16413920
J Exp Med. 2008 Dec 22;205(13):3053-64
19075288
J Leukoc Biol. 2006 Sep;80(3):546-54
16822853
Cell Metab. 2010 Apr 7;11(4):248-52
20374955
Autoimmunity. 2006 Mar;39(2):137-41
16698670
Perit Dial Int. 2005 Jan-Feb;25(1):48-57
15770926
J Exp Med. 2009 Jan 16;206(1):233-48
19139167
Life Sci. 2006 Aug 8;79(11):1056-61
16650442
Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1608-14
19644053
Ann N Y Acad Sci. 2009 Sep;1173:260-7
19758160
Trends Immunol. 2008 Jan;29(1):34-40
18289504
Anat Rec. 1996 Feb;244(2):235-45
8808398
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2691-8
17690315
Circulation. 2007 Feb 27;115(8):1029-38
17296858
Perit Dial Int. 2005 Jan-Feb;25(1):30-2
15770922
Blood. 2009 Jun 25;113(26):6638-47
19363220
Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E656-65
17578888
Scand J Immunol. 2010 Feb;71(2):115-22
20384863
Circ Res. 2008 Aug 29;103(5):467-76
18658050
Int J Obes (Lond). 2008 Mar;32(3):451-63
17895881
Nature. 1998 Aug 27;394(6696):897-901
9732873