Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors.
A series of novel bis-salicylaldehydes were synthesised and evaluated as tyrosinase inhibitors using a tyrosinase-dependent L-DOPA oxidation assay. The bis-salicylaldehydes exhibited greater inhibitory activity than salicylaldehyde. Our data suggests that these novel compounds may serve as a structural template for the design and development of novel tyrosinase inhibitors.
Delogu
Giovanna
G
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Cagliari, Cagliari, CA, Italy. delogug@unica.it
Podda
Gianni
G
Corda
Marcella
M
Fadda
Maria Benedetta
MB
Fais
Antonella
A
Era
Benedetta
B
D000363:Agaricales / Q000201:enzymology*; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010084:Oxidation-Reduction
D000447:Aldehydes; D004791:Enzyme Inhibitors; C013243:salicylaldehyde; D014442:Monophenol Monooxygenase