Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products.
Two new dihydrofuranoisoflavanones, 2',4',5-trihydroxy-[5''-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2'',3'':7,8)]-(3S)-isoflavanone (1) and 2', 4', 5-trihydroxy-[5''-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2'',3'':7,8)]-(3R)-isoflavanone (2) as well as one already-known compound, (+)-catechin (3), were isolated from an n-BuOH soluble fraction from the leaves of Lespedeza maximowiczi. Spectroscopic data was used to elucidate the structures of compounds 1 and 2. All of the isolates were evaluated in vitro for their inhibitory activity on the formation of advanced glycation end products (AGEs). Among these, compounds 1, 2, and 3 exhibited inhibitory activity against AGEs formation with IC(50) values of 20.6, 18.4, and 5.6 microM, respectively.
Park
Hyun Young
HY
College of Pharmacy, Kangwon National University, Chuncheon, 200-701, Korea.
Kim
Gi Beom
GB
Kwon
Yong Soo
YS
D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D029884:Lespedeza / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D013057:Spectrum Analysis
D017127:Glycation End Products, Advanced; D007529:Isoflavones; D010936:Plant Extracts; C065753:isoflavanone