title: Identification of promoter regions and regulatory sites.
abstract: Promoter sequences are the main regulatory elements of gene expression. Their recognition by computer algorithms is fundamental for understanding gene expression patterns, cell specificity and development. This chapter describes the advanced approaches to identify promoters in animal, plant and bacterial sequences. Also, we discuss an approach to identify statistically significant regulatory motifs in genomic sequences.
authors.affiliation: Department of Computer Science, Royal Holloway, London, UK.
authors.forename: Victor V
authors.initials: VV
authors.lastname: Solovyev
authors.forename: Ilham A
authors.initials: IA
authors.lastname: Shahmuradov
authors.forename: Asaf A
authors.initials: AA
authors.lastname: Salamov
mesh_terms: D000465:Algorithms; D000818:Animals; D001419:Bacteria / Q000235:genetics; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010944:Plants / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors; D004247:DNA