Total antioxidant capacity of diet in relation to cognitive function and decline.
BACKGROUND
Epidemiologic evidence on the association of individual antioxidant vitamins and cognition is inconsistent.


OBJECTIVE
We evaluated the total antioxidant capacity of diets on the basis of the ferric-reducing antioxidant power (FRAP) assay in relation to cognition in older women.


METHODS
Starting in 1995, we used a telephone-based cognitive assessment to evaluate cognitive function on 3 occasions at 2-y intervals in 16,010 participants aged ≥70 y in the Nurses' Health Study. In 1980, and every 4 y thereafter, we collected dietary information by using a semiquantitative food-frequency questionnaire (FFQ). For each participant, we combined FFQ data with food- and supplement-specific FRAP values to obtain FRAP scores; these data were averaged from 1980 until the initial cognitive interview to reflect long-term diets. We used multivariable-adjusted linear regression to estimate mean differences in initial cognitive function and slopes of decline across quintiles of FRAP scores.


RESULTS
In multivariable-adjusted models, there was an association between higher total FRAP scores and better cognitive function at the first interview (P for trend = 0.003 for global scores with all cognitive tests combined; mean difference = 0.04 standard units; 95% CI: 0.01, 0.08 standard units, comparing the highest and lowest quintiles). A weaker association was observed for dietary FRAP scores (excluding supplements) and initial global scores (P for trend = 0.05). However, prospective analyses of cognitive decline indicated no associations with total or dietary FRAP scores in models adjusted for multiple potential confounders (P for trend = 0.3 and 0.5 for global scores, respectively).


CONCLUSIONS
We observed no clear evidence of a consistent association between the total antioxidant capacity of diets and cognition in this cohort of older women.
Devore
Elizabeth E
EE
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. edevore@partners.org
Kang
Jae Hee
JH
Stampfer
Meir J
MJ
Grodstein
Francine
F
D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000517:prevention & control; D004032:Diet; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D011446:Prospective Studies; D012044:Regression Analysis; D011795:Surveys and Questionnaires
D000975:Antioxidants
Neurology. 2006 Oct 24;67(8):1370-6
17060562
N Engl J Med. 2005 Jun 9;352(23):2379-88
15829527
Anal Biochem. 1996 Jul 15;239(1):70-6
8660627
Arch Neurol. 1991 Mar;48(3):278-81
2001185
Mol Aspects Med. 2002 Feb-Jun;23(1-3):1-38
12079769
Neuroepidemiology. 2006;26(2):93-101
16352912
Redox Rep. 2004;9(3):145-52
15327744
Neurology. 2007 Feb 27;68(9):670-6
17325274
Am J Clin Nutr. 2007 Jun;85(6):1634-42
17556703
Brain. 1991 Dec;114 ( Pt 6):2521-42
1782529
Arch Neurol. 1995 Nov;52(11):1087-99
7487561
Neurology. 2004 Nov 9;63(9):1705-7
15534261
Nutrition. 2010 May;26(5):534-41
19783122
Arch Neurol. 2002 Jul;59(7):1125-32
12117360
Alzheimers Dement. 2007 Apr;3(2 Suppl):S16-22
19595969
JAMA. 2004 Sep 22;292(12):1454-61
15383516
Neurology. 1989 Sep;39(9):1159-65
2771064
Am J Clin Nutr. 2008 May;87(5):1247-53
18469246
J Nutr Health Aging. 2007 May-Jun;11(3):230-7
17508099
Neurobiol Aging. 2005 Mar;26(3):335-40
15639311
Neurology. 2009 Jun 9;72(23):2029-35
19506226
Arch Gen Psychiatry. 2001 Sep;58(9):859-60
11545669
N Engl J Med. 2005 Jan 20;352(3):245-53
15659724
Ann Neurol. 2005 May;57(5):713-20
15852398
Arch Neurol. 1992 Dec;49(12):1253-8
1449404
Am J Epidemiol. 1997 Jan 1;145(1):33-41
8982020
Am J Epidemiol. 1999 Mar 15;149(6):531-40
10084242
J Neurosci. 1998 Oct 1;18(19):8047-55
9742171
Int J Neurosci. 1991 Apr;57(3-4):167-78
1938160
Arch Intern Med. 2006 Dec 11-25;166(22):2462-8
17159011
J Nutr. 2007 Jan;137(1):93-8
17182807
Eur J Clin Nutr. 2010 Feb;64(2):161-8
19904292
Int J Epidemiol. 1989 Dec;18(4):858-67
2621022
Cell Tissue Res. 1997 Dec;290(3):471-80
9369525
Am J Epidemiol. 1985 Jul;122(1):51-65
4014201
Am J Clin Nutr. 2000 Feb;71(2):621S-629S
10681270
J Neurosci. 1999 Sep 15;19(18):8114-21
10479711
Am J Clin Nutr. 1997 Apr;65(4 Suppl):1220S-1228S; discussion 1229S-1231S
9094926
Brain Res. 1995 Sep 25;693(1-2):88-94
8653426
Arch Intern Med. 2007 Nov 12;167(20):2184-90
17998490
Am J Clin Nutr. 2006 Jul;84(1):95-135
16825686
Circulation. 2009 Jun 2;119(21):2772-80
19451353