title: Increased biomagnetic activity in healthy elderly with subjective memory complaints.
abstract: OBJECTIVE
  Subjective memory complaints (SMCs) are frequently reported by elderly people with or without objective cognitive impairment (OMI) as assessed by neuropsychological tests. We investigate whether SMCs are associated with altered brain biomagnetic patterns even in the absence of OMI.
  
  
  METHODS
  We report spatio-temporal patterns of brain magnetic activity recorded with magnetoencephalography during a memory task in 51 elderly participants divided into the following groups: patients with mild cognitive impairment (MCI) with SMC and OMI, individuals with SMC but not OMI, and healthy controls without neither SMC nor OMI. Exclusion criteria for all three groups included a diagnosis of depression or any other psychiatric condition.
  
  
  RESULTS
  No statistically significant differences were found between MCI patients and participants with SMC. However, the SMC showed higher activation, between 200 and 900 ms after stimulus onset, than the control group in posterior ventral regions and in the dorsal pathway. MCI patients showed higher activation than the control group in the posterior part of the ventral pathway.
  
  
  CONCLUSIONS
  These findings suggest that similar physiological mechanisms may underlie SMC and MCI, which could be two stages in a cognitive continuum.
  
  
  CONCLUSIONS
  MEG provide different neurophysiological profiles between SMC and control subjects.
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain; Departamento de Psicología Básica II, Universidad Complutense de Madrid, Spain. Electronic address: fmaestuu@psi.ucm.es.
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestu
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Baykova
authors.affiliation: Centro de Prevención del Deterioro Cognitivo del Ayuntamiento de Madrid, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Ruiz
authors.affiliation: Centro de Prevención del Deterioro Cognitivo del Ayuntamiento de Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Montejo
authors.affiliation: Centro de Prevención del Deterioro Cognitivo del Ayuntamiento de Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Montenegro
authors.affiliation: Centro de Prevención del Deterioro Cognitivo del Ayuntamiento de Madrid, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: Llanero
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain; Departamento de Psicología Básica II, Universidad Complutense de Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Solesio
authors.affiliation: Hospital Universitario San Carlos, Servicio de Geriatría Unidad de Memoria, Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Gil
authors.affiliation: Hospital Universitario San Carlos, Servicio de Geriatría Unidad de Memoria, Madrid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Yubero
authors.affiliation: Departamento de Psiquiatría, Universidad Complutense de Madrid, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Paul
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Pozo
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain; Departamento de Psicología Básica II, Universidad Complutense de Madrid, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Nevado
mesh_terms: D000368:Aged / Q000502:physiology*; D001921:Brain / Q000503:physiopathology; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology* / Q000523:psychology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology