Probiotics for photoprotection.
Specific strains of probiotic, have been identified as beneficial to influence the composition and/or metabolic activity of the endogenous microbiota and some of these strains have been also shown to inhibit the growth of a wide range of enteropathogens. The first aim of using probiotics has been to improve the composition of the intestinal microbiota from a potentially harmful composition towards a composition that would be beneficial to the host.Beyond their capacity to influence positively the composition of the intestinal microbiota, several lines of evidence suggest that some probiotic bacteria can modulate the immune system both at the local and systemic levels thereby improving immune defense mechanisms and/or downregulate immune disorders such as allergies or intestinal inflammation.Skin reflects the general health status and aging. Different human trials widely suggest that probiotic supplementation might be useful in the management of atopic dermatitis. Based on these properties it appears that, beyond the gut, probiotics might exert their benefits at the skin level.In a randomized double blind placebo-controlled clinical trial, we investigated whether the probiotic bacteria Lactobacillus johnsonii NCC 533 (La1) could modulate the cutaneous immune homeostasis altered by solar-simulated UV exposure in humans. After, UV exposure to twice 1.5 MED, we demonstrated that La1 intake facilitated an earlier recovery of Epidermal cells allostimulatory function. Thus, this clinical data strengthen the assumption that certain probiotics can contribute to modulate skin immune system leading to the preservation of the skin homeostasis. Altogether the data affords the possibility of designing new strategies based on a nutritional approach for the prevention of UV-induced damaging effects.
Guéniche
Audrey
A
Philippe
David
D
Bastien
Philippe
P
Blum
Stephanie
S
Buyukpamukcu
Elif
E
Castiel-Higounenc
Isabelle
I
Br J Dermatol. 2003 Feb;148(2):291-9
12588382
Lancet. 2001 Apr 7;357(9262):1076-9
11297958
J Nutr. 2005 May;135(5):1294-8
15867327
J Appl Bacteriol. 1995 Oct;79(4):475-9
7592140
FEMS Microbiol Lett. 1993 Jul 1;110(3):299-305
8354463
J Exp Med. 1996 Dec 1;184(6):2417-22
8976197
FEMS Immunol Med Microbiol. 2003 Sep 22;38(2):165-72
13129651
J Pediatr Gastroenterol Nutr. 1995 Aug;21(2):177-81
7472904
Am J Clin Nutr. 2000 Apr;71(4):861-72
10731490
Appl Environ Microbiol. 1997 Jul;63(7):2747-53
9212421
Gut. 2000 Jul;47(1):79-87
10861268
Photochem Photobiol. 1995 Sep;62(3):389-401
8570698
J Appl Bacteriol. 1989 May;66(5):365-78
2666378
Photochem Photobiol. 1996 Apr;63(4):394-6
8934747
FEMS Immunol Med Microbiol. 1994 Nov;10(1):55-63
7874079
Front Biosci. 2002 Mar 01;7:d684-703
11861222
Exp Gerontol. 2000 May;35(3):307-16
10832052
J Allergy Clin Immunol. 2007 Apr;119(4):1019-21
17289135
Infect Immun. 1996 Dec;64(12):5403-5
8945595
J Clin Invest. 2003 Sep;112(5):648-51
12952911
Clin Chim Acta. 2006 Feb;364(1-2):1-11
16153626
J Pediatr Gastroenterol Nutr. 2001 Oct;33 Suppl 2:S17-25
11698781
Mutat Res. 2005 Apr 1;571(1-2):185-205
15748647
Am J Clin Nutr. 1999 May;69(5):1046S-1051S
10232647
Antonie Van Leeuwenhoek. 2002 Aug;82(1-4):279-89
12369194
Clin Exp Allergy. 2000 Nov;30(11):1604-10
11069570
J Exp Med. 1996 Apr 1;183(4):1491-500
8666907
Appl Environ Microbiol. 1998 Nov;64(11):4573-80
9797324
J Food Prot. 1999 Dec;62(12):1435-44
10606148
Pediatr Allergy Immunol. 2001;12 Suppl 14:56-9
11380901
Pediatrics. 2005 Aug;116(2):e221-8
15995003
J Invest Dermatol. 1999 May;112(5):692-8
10233758
J Dairy Sci. 1995 Mar;78(3):491-7
7782506
Lancet. 2003 May 31;361(9372):1869-71
12788576
Eur J Immunol. 1997 Apr;27(4):984-9
9130654
Am J Clin Nutr. 2001 Feb;73(2 Suppl):444S-450S
11157355
Semin Immunol. 2005 Aug;17(4):273-83
15953735
Nutr Rev. 1995 May;53(5):127-30
7666984
Nutrition. 2003 Sep;19(9):716-21
12921879
Curr Issues Intest Microbiol. 2002 Mar;3(1):15-22
12022809
Clin Diagn Lab Immunol. 2001 Jul;8(4):695-701
11427413
Nat Immunol. 2006 Mar;7(3):265-73
16444257
Nat Immunol. 2002 Dec;3(12):1135-41
12415265
J Immunol. 1985 Jan;134(1):129-37
3964811
Am J Gastroenterol. 2000 Jan;95(1 Suppl):S11-3
10634221
N Engl J Med. 2003 Apr 24;348(17):1681-91
12711744
J Immunol. 2002 Jan 1;168(1):171-8
11751960
Pediatr Res. 1992 Aug;32(2):141-4
1324462
J Nutr. 2000 Feb;130(2S Suppl):396S-402S
10721914
Eur J Dermatol. 2008 Sep-Oct;18(5):504-11
18693151
Am J Gastroenterol. 2003 Apr;98(4):865-70
12738469
Immunology. 1988 Jan;63(1):17-23
3123370
Digestion. 2005;72(1):57-68
16113543
J Clin Microbiol. 2006 Nov;44(11):4025-31
16971641
J Dairy Sci. 1998 Jan;81(1):48-53
9493081