Tunable acoustophoretic band-pass particle sorter.
Acoustophoretic separation in microchannels offers a promising avenue for high-throughput, label-free, cell and particle separation for many applications. However, previous acoustophoretic separation approaches have been limited to a single size separation threshold, analogous to a binary filter, (i.e., high-pass or low-pass). Here, we describe a tunable acoustophoretic separation architecture capable of sorting cells and particles based on a range of sizes, analogous to a band-pass filter. The device is capable of sorting an arbitrary range of particle sizes between 3 and 10 mum in diameter with high efficiency (transfer fraction=0.98+/-0.02) at a throughput of approximately 10(8) particleshmicrochannel.
Adams
Jonathan D
JD
Soh
H Tom
HT
Biotechnol Bioeng. 1997 May 5;54(3):239-50
18634090
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20708-12
18093921
Ultrasonics. 2009 Jan;49(1):112-9
18701122
Anal Bioanal Chem. 2010 Aug;397(8):3249-67
20419490
Anal Chem. 2009 Aug 1;81(15):6089-95
19591449
Chem Soc Rev. 2010 Mar;39(3):1203-17
20179832
Biotechniques. 2001 Jun;30(6):1322-6, 1328, 1330-1
11414226
Anal Chem. 2008 May 1;80(9):3135-43
18363383
Lab Chip. 2010 Feb 21;10(4):438-45
20126683
Anal Chem. 2010 Apr 1;82(7):3094-8
20199060
Anal Chem. 2009 Aug 1;81(15):6195-200
19572705
Appl Phys Lett. 2009 Dec 21;95(25):254103
20087428
Lab Chip. 2008 Jul;8(7):1178-84
18584095
Anal Chem. 2009 Mar 1;81(5):1964-8
19245266
Curr Opin Biotechnol. 2003 Feb;14(1):5-12
12565996
Ultrasound Med Biol. 2007 Jan;33(1):145-51
17189057
Lab Chip. 2010 Mar 7;10(5):563-70
20162231
Lab Chip. 2005 Jan;5(1):20-2
15616735
Anal Chem. 2007 Jul 15;79(14):5117-23
17569501
Chem Soc Rev. 2007 Mar;36(3):492-506
17325788