Braak staging in mouse models of Alzheimer's disease.
In the present paper by David E. Hurtado and colleagues report on a new mouse model for AD bearing Aβ and MAPT pathology by crossing PS19 and PDAPP Tg mice. Here, we tried to highlight the importance and necessity of the critical and systematic analysis of models such as the Braak like staging in AD mouse models.
Granic
Ivica
I
Department of Molecular Neurobiology, University of Groningen, POB 14, 9728 AA Haren, The Netherlands.
Masman
Marcelo F
MF
Luiten
Paul G M
PG
Eisel
Ulrich L M
UL
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D016875:tau Proteins
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