title: Development of Practical Methodologies for the Synthesis of Functionalized Benzoboroxoles.
abstract: 2-Formylphenylboronic acids upon reaction with activated olefins such as acrylates, methyl vinyl ketone, and acrylonitrile, etc. provide functionalized benzoboroxoles. The corresponding homologated benzoboroxoles were synthesized via the reaction of 2-formylphenylboronic acids with α-bromomethylacrylates.
authors.affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN 55812.
authors.forename: J Sravan
authors.initials: JS
authors.lastname: Kumar
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Bashian
authors.forename: Michael A
authors.initials: MA
authors.lastname: Corsello
authors.forename: Subash C
authors.initials: SC
authors.lastname: Jonnalagadda
authors.forename: Venkatram R
authors.initials: VR
authors.lastname: Mereddy
references.citation: Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2708-2714
references.pmid: 29711605
references.citation: Cancer Cell. 2005 Nov;8(5):407-19
references.pmid: 16286248
references.citation: J Med Chem. 2006 Jul 27;49(15):4447-50
references.pmid: 16854048
references.citation: Tetrahedron Lett. 2010 Feb 3;51(5):779-782
references.pmid: 20161580
references.citation: Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32
references.pmid: 19303290
references.citation: J Med Chem. 1990 Feb;33(2):819-23
references.pmid: 1967653
references.citation: Chem Soc Rev. 2007 Oct;36(10):1581-8
references.pmid: 17721583
references.citation: J Biol Chem. 1984 Dec 25;259(24):15106-14
references.pmid: 6392293
references.citation: Chem Rev. 2003 Mar;103(3):811-92
references.pmid: 12630854
references.citation: J Am Chem Soc. 2006 Apr 5;128(13):4226-7
references.pmid: 16568987
references.citation: Med Res Rev. 2003 May;23(3):346-68
references.pmid: 12647314
references.citation: Br J Cancer. 2006 Oct 23;95(8):961-5
references.pmid: 17047643
references.citation: Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1492-5
references.pmid: 20084659
references.citation: J Med Chem. 1996 May 10;39(10):2087-94
references.pmid: 8642568