title: Study on the mechanism of potential response of a ketamine-sensitive membrane electrode.
abstract: The response mechanism of a simple device for the rapid detection of ketamine with 'in the field' capabilities is investigated. The mechanism is a membranous ketamine ionic selective electrode (ISE) with partly carboxylated PVC as matrix and ortho-nitrophenyloctyl ether (o-NPOE) as plasticizer. The experimental results reveal that the inclusion of the plasticizer in the membrane significantly increased the response. A mechanism is proposed where the infiltration of a target species into the membrane is capable of producing a superior response. This response process is non-selective for species with similar molecular structure and size. This new research addresses some omissions and misapprehension in the literature where the mechanism was reported as an ion-exchange-induced response. In this research the ion-exchange-induced response was measurable after the elimination of the infiltration-induced response extending to lower concentration ranges and thus providing the potential for better sensitivity and selectivity.
authors.affiliation: Institute of Analytical Chemistry, Department of Chemistry, Suzhou University, Suzhou, PR China.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Ling
authors.forename: Ya
authors.initials: Y
authors.lastname: Yang
authors.forename: Shizhong
authors.initials: S
authors.lastname: Bian
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Tu
mesh_terms: D000700:Analgesics / Q000032:analysis*; D004987:Ethers / Q000737:chemistry; D017736:Ion-Selective Electrodes; D007649:Ketamine / Q000032:analysis*; D010968:Plasticizers / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry
chemical_list: C519952:2-nitrophenyl octyl ether; D000700:Analgesics; D004987:Ethers; D010968:Plasticizers; D007649:Ketamine; D011143:Polyvinyl Chloride