title: Preparation and antimicrobial activity of scleraldehyde from Schizophyllum commune.
abstract: The present study investigates the antimicrobial activity of oxidized schizophyllan (scleraldehyde) against Gram-positive and Gram-negative bacteria by diffusion and tube dilution analysis. Schizophyllan is a natural polysaccharide produced by fungi of the genus Schizophyllum. Periodate oxidation specifically cleaves the vicinal glycols in scleraldehyde to form their dialdehyde derivatives. The antibacterial activity exhibited by scleraldehyde was defined using various tests such as the disc diffusion assay, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). MIC and MBC values were found to be in the range of 3.0-8.0 mg/mL. Hence, the present studies establish that the scleraldehyde possesses effective antibacterial properties and can be used as a biopreservative for preservation of raw hides and skins.
authors.affiliation: Centre for Human and Organizational Resources Development, Central Leather Research Institute, Council of Scientific and Industrial Research, Adyar, Chennai 600 020, India.
authors.forename: Gladstone Christopher
authors.initials: GC
authors.lastname: Jayakumar
authors.forename: Swarna V
authors.initials: SV
authors.lastname: Kanth
authors.forename: B
authors.initials: B
authors.lastname: Chandrasekaran
authors.forename: J
authors.initials: J
authors.lastname: Raghava Rao
authors.forename: B U
authors.initials: BU
authors.lastname: Nair
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D006041:Goats; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D011310:Preservatives, Pharmaceutical; D012567:Schizophyllum / Q000737:chemistry*; D012867:Skin; D014021:Tissue Preservation / Q000379:methods
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D011134:Polysaccharides; D011310:Preservatives, Pharmaceutical