title: The distribution of CD56(dim) CD16+ and CD56(bright) CD16- cells are associated with prolactin levels during pregnancy and menstrual cycle in healthy women.
abstract: OBJECTIVE
  The pregnancy and menstrual cycle (MC) are the main physiologic events linked to the human reproduction. An adequate neuroendocrine axis is mandatory for the homeostasis in both events. To analyze the distribution of NK, T, Treg cells, expression of their receptors and to associate with hormone levels in pregnant and MC in healthy women.
  
  
  METHODS
  We studied two groups of healthy women: 13 pregnant women followed up at 1st, 2nd and 3rd trimesters and 11 women in the 5th and 21st day of the MC. The distribution of NK, T, Treg cells population, expression of their receptors and hormone levels were quantified.
  
  
  RESULTS
  In pregnant women, we found an association of NK cells CD56(dim) CD16(+) with prolactin levels. This finding was also was observed for CD56(brigthCD16-) being statistical significant during 1st trimester for both subpopulations. During MC, correlation of CD56(dim) CD16(+) , CD56(bright) CD16(-) cells with prolactin in follicular and luteal phase was found.
  
  
  CONCLUSIONS
  This is the first report where these cell subpopulations have been analyzed prospectively. Even we can argue the random effect for the small number of women is interesting that prolactin showed the more consistent correlation with CD56(dim) CD16(+) , CD56(brigth) CD16(-) cells during both events studied.
authors.affiliation: Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, CUCS, Universidad de Guadalajara, Jalisco, México.
authors.forename: Erika A
authors.initials: EA
authors.lastname: Martínez-García
authors.forename: Pedro E
authors.initials: PE
authors.lastname: Sánchez-Hernández
authors.forename: Bernardo
authors.initials: B
authors.lastname: Chavez-Robles
authors.forename: Lourdes
authors.initials: L
authors.lastname: Nuñez-Atahualpa
authors.forename: Beatriz T
authors.initials: BT
authors.lastname: Martín-Márquez
authors.forename: Victor E
authors.initials: VE
authors.lastname: Arana-Argaez
authors.forename: Trinidad
authors.initials: T
authors.lastname: García-Iglesias
authors.forename: Laura
authors.initials: L
authors.lastname: González-López
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Gamez-Nava
authors.forename: Marcelo H
authors.initials: MH
authors.lastname: Petri
authors.forename: Juan
authors.initials: J
authors.lastname: Velazquez-Rodriguez
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Paramo
authors.forename: Ingrid P
authors.initials: IP
authors.lastname: Davalos-Rodriguez
authors.forename: Adrian
authors.initials: A
authors.lastname: Daneri-Navarro
authors.forename: Mónica
authors.initials: M
authors.lastname: Vázquez-Del Mercado
mesh_terms: D000328:Adult; D019002:CD56 Antigen / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D058851:GPI-Linked Proteins / Q000032:analysis; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008597:Menstrual Cycle / Q000097:blood* / Q000276:immunology; D011247:Pregnancy / Q000097:blood* / Q000276:immunology; D011388:Prolactin / Q000097:blood*; D017452:Receptors, IgG / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D019002:CD56 Antigen; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; C522918:NCAM1 protein, human; D017452:Receptors, IgG; D011388:Prolactin