Small-molecule regulators that mimic transcription factors.
Transcription factors (TFs) are responsible for decoding and expressing the information stored in the genome, which dictates cellular function. Creating artificial transcription factors (ATFs) that mimic endogenous TFs is a major goal at the interface of biology, chemistry, and molecular medicine. Such molecular tools will be essential for deciphering and manipulating transcriptional networks that lead to particular cellular states. In this minireview, the framework for the design of functional ATFs is presented and current challenges in the successful implementation of ATFs are discussed.
Rodríguez-Martínez
José A
JA
Department of Biochemistry and Genome Center, University of Wisconsion-Madison, WI 53706, USA.
Peterson-Kaufman
Kimberly J
KJ
Ansari
Aseem Z
AZ
D000818:Animals; D006801:Humans; D057786:Peptidomimetics / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000187:drug effects
D057786:Peptidomimetics; D014157:Transcription Factors
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