Hydrogen sulfide, the third gaseous signaling molecule with cardiovascular properties, is decreased in hemodialysis patients.
Hydrogen sulfide, H(2)S, is the third endogenous gas with cardiovascular properties, after nitric oxide and carbon monoxide. H(2)S is a potent vasorelaxant, and its deficiency is implicated in the pathogenesis of hypertension and atherosclerosis. Cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase catalyze H(2)S formation. Chronic kidney disease is characterized by high prevalence of hyperhomocysteinemia, hypertension, and high cardiovascular mortality, especially in hemodialysis patients. H(2)S levels are decreased in hemodialysis patients through transcriptional deregulation of genes encoding for the H(2)S-producing enzymes. Potential implications relate to the pathogenesis of the manifestations of the uremic syndrome, such as hypertension and atherosclerosis.
Perna
Alessandra F
AF
First Division of Nephrology, Department of Clinical and Experimental Internal Medicine, Second University of Medicine, Naples, Italy. alessandra.perna@unina2.it
Luciano
Maria Grazia
MG
Ingrosso
Diego
D
Raiola
Ilaria
I
Pulzella
Paola
P
Sepe
Immacolata
I
Lanza
Diana
D
Violetti
Eleonora
E
Capasso
Rosanna
R
Lombardi
Cinzia
C
De Santo
Natale G
NG
D002318:Cardiovascular Diseases / Q000209:etiology; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood* / Q000378:metabolism; D020138:Hyperhomocysteinemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D006435:Renal Dialysis; D013466:Sulfurtransferases / Q000378:metabolism; D014511:Uremia / Q000097:blood / Q000201:enzymology; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D013466:Sulfurtransferases; C021550:3-mercaptopyruvate sulphurtransferase; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide