Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction.
A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.
Zhu
Xu
X
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Xu
Xiao-Ping
XP
Sun
Chang
C
Wang
Hai-Ying
HY
Zhao
Kai
K
Ji
Shun-Jun
SJ
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003486:Cyanides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013871:Thiones / Q000737:chemistry*
D003486:Cyanides; D007097:Imines; D011759:Pyrrolidines; D013871:Thiones; C032519:pyrrolidine