title: Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation.
abstract: Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated membranoproliferative glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I membranoproliferative glomerulonephritis. Salivary gland biopsy demonstrated mild lymphocytic infiltration, indicating chronic GVHD. Improvement of the proteinuria and recovery of renal function were achieved within 11 months of treatment with oral prednisolone and azathioprine.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Republic of Korea.
authors.forename: Ju Youn
authors.initials: JY
authors.lastname: Kim
authors.forename: Min Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Biro
authors.initials: B
authors.lastname: Kim
authors.forename: Cheol Whee
authors.initials: CW
authors.lastname: Park
authors.forename: Yoon Sik
authors.initials: YS
authors.lastname: Chang
authors.forename: Sungjin
authors.initials: S
authors.lastname: Chung
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006086:Graft vs Host Disease / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D011239:Prednisolone; D001379:Azathioprine
references.citation: Clin Nephrol. 2007 Jan;67(1):5-11
references.pmid: 17269593
references.citation: Am J Kidney Dis. 1995 Sep;26(3):532-4
references.pmid: 7645565
references.citation: Clin Nephrol. 1992 Mar;37(3):115-8
references.pmid: 1563114
references.citation: Nat Rev Nephrol. 2009 Apr;5(4):236-40
references.pmid: 19322189
references.citation: Clin Nephrol. 2002 Sep;58(3):231-7
references.pmid: 12356194
references.citation: Bone Marrow Transplant. 1995 Aug;16(2):303-5
references.pmid: 7581152