Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran.
A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.
Hammarson
Martin
M
Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, 412 96 Göteborg, Sweden.
Andersson
Johanna
J
Li
Shiming
S
Lincoln
Per
P
Andréasson
Joakim
J
D000970:Antineoplastic Agents / Q000378:metabolism; D001578:Benzopyrans / Q000378:metabolism*; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D007364:Intercalating Agents / Q000378:metabolism*; D008958:Models, Molecular; D009574:Nitro Compounds / Q000378:metabolism*; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D001578:Benzopyrans; D007211:Indoles; D007364:Intercalating Agents; D009574:Nitro Compounds; C088184:spiropyran; D004247:DNA