Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women.
There are limited data on diversity within the hepatitis C virus polymerase (NS5B). In concordance with its key functional role during the life cycle, NS5B intrapatient variability was low. Moreover, differences between NS5B nonsynonymous (dN) and synonymous (dS) mutation rates (dN - dS) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication in vivo.
Blackard
Jason T
JT
Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. jason.blackard@uc.edu
Ma
Gang
G
Limketkai
Berkeley N
BN
Welge
Jeffrey A
JA
Dryer
Peter D
PD
Martin
Christina M
CM
Hiasa
Yoichi
Y
Taylor
Lynn E
LE
Mayer
Kenneth H
KH
Jamieson
Denise J
DJ
Sherman
Kenneth E
KE
D000595:Amino Acid Sequence; D018791:CD4 Lymphocyte Count; D005260:Female; D014644:Genetic Variation; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006526:Hepatitis C / Q000276:immunology / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D017361:Viral Nonstructural Proteins / Q000235:genetics*; D012324:RNA-Dependent RNA Polymerase
D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase
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