title: Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial.
abstract: BACKGROUND
  Immunoglobulin A (IgA) secretion in saliva decreases with age and may be the cause of increased vulnerability of the elderly to respiratory infections. The effect of oral intake of lactic acid bacteria on salivary secretory IgA (SIgA) in the elderly has not been reported. The objective of this study was to demonstrate the acceleration of salivary SIgA secretion by oral intake of Lactobacillus pentosus strain b240 (b240) in the elderly.
  
  
  RESULTS
  A total of 80 healthy elderly individuals were randomly allocated to either an intervention (i.e., b240) or a control (i.e., placebo) group. The elderly individuals in the b240 group were given a sterile water beverage (125 mL) containing heat-killed b240 (4 × 109 cells), while those in the placebo group were given only a sterile water beverage (125 mL); both groups received their respective beverages once daily for 12 weeks. Saliva was collected before initiation of the study and every 2 weeks thereafter. Saliva flow rate and SIgA concentration were determined, and the SIgA secretion rate was calculated. The mean salivary SIgA secretion rate in the b240 group steadily increased until week 4 (exhibiting a 20% elevation relative to that at week 0), and then remained stable until week 12. Changes in SIgA secretion rate over the intervention period were significantly greater in the b240 group than in the placebo group. The treatment groups exhibited no significant differences in adverse events.
  
  
  CONCLUSIONS
  Oral intake of L. pentosus strain b240 for 12 weeks significantly accelerated salivary SIgA secretion, thereby indicating its potential utility in the improvement of mucosal immunity and resistance against infection in the elderly.
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co,, Ltd,, Shiga, Japan. y_kotani@research.otsuka.co.jp.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kotani
authors.forename: Shoji
authors.initials: S
authors.lastname: Shinkai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okamatsu
authors.forename: Masamichi
authors.initials: M
authors.lastname: Toba
authors.forename: Kishiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshida
authors.forename: Taro
authors.initials: T
authors.lastname: Fukaya
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Paulo Hm
authors.initials: PH
authors.lastname: Chaves
authors.forename: Keiji
authors.initials: K
authors.lastname: Kakumoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kohda
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