The culture of olfactory ensheathing cells (OECs)--a distinct glial cell type.
Olfactory ensheathing cells (OECs) have become a popular candidate for the transplant-mediated repair of the damaged CNS. In this review a description is made of the origins of these cells and a historical development of their purification and maintenance in culture. In addition, we illustrate the cellular and molecular characteristics of OECs and emphasise that although they share many properties with Schwann cells, they possess several inherent differences which may allow them to be more beneficial for CNS repair. In summary, OECs are distinct glial cells and the detailed understanding of their biological and molecular properties is essential in ensuring their clinical efficacy after cell transplantation. This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair.
Higginson
Jennifer R
JR
Institute of Infection, Immunity and Inflammation College of Medical, Veterinary & Life Sciences, Glasgow Biomedical Research Centre, 120 University Place, Glasgow, UK.
Barnett
Susan C
SC
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D006801:Humans; D009457:Neuroglia / Q000166:cytology* / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology* / Q000502:physiology*; D009831:Olfactory Mucosa / Q000166:cytology / Q000502:physiology; D012583:Schwann Cells / Q000166:cytology / Q000502:physiology
Exp Neurol. 1994 Jun;127(2):232-44
8033963
J Gen Physiol. 1956 Mar 20;39(4):473-96
13295549
Virus Res. 2009 Sep;144(1-2):195-201
19433119
J Neurosci Res. 2009 May 15;87(7):1556-64
19140223
Glia. 2005 Mar;49(4):577-87
15593099
Cell Res. 2008 Apr;18(4):479-90
18347613
Glia. 2010 Apr;58(5):546-58
19908289
Brain Res. 2010 Jun 14;1337:8-20
20399758
Mol Cell Neurosci. 2005 Feb;28(2):253-63
15691707
Mol Cell Biol. 1998 Nov;18(11):6245-52
9774641
Brain. 2005 Dec;128(Pt 12):2951-60
16219671
Glia. 2001 Apr 15;34(2):81-7
11307157
Glia. 1992;5(4):269-84
1534071
Neuroscience. 1982;7(12):3077-90
6761599
Glia. 2006 Mar;53(4):434-40
16345031
Glia. 2000 Dec;32(3):214-25
11102963
J Comp Neurol. 2007 Dec 10;505(5):572-85
17924534
J Neurosci. 1998 Dec 15;18(24):10514-24
9852589
J Anat. 1982 Jan;134(Pt 1):149-68
7076541
Development. 1990 May;109(1):91-103
2209471
J Neurosci Res. 1993 Jun 15;35(3):274-87
8350389
Cell Tissue Res. 2002 Sep;309(3):337-45
12195289
Anat Rec. 1984 Oct;210(2):385-91
6507903
J Comp Neurol. 2003 Mar 31;458(2):175-94
12596257
J Comp Neurol. 2002 Apr 22;446(1):68-80
11920721
Glia. 2004 Jan 15;45(2):111-23
14730705
J Neurosci. 2010 Mar 24;30(12):4246-55
20335460
J Neurotrauma. 2011 Aug;28(8):1611-82
20146557
EMBO J. 1984 Oct;3(10):2243-7
6542000
Stem Cells Dev. 2010 Jun;19(6):853-66
19905894
Glia. 2005 Jan 1;49(1):24-35
15390106
Dev Biol. 1988 Nov;130(1):237-49
3181629
Glia. 2001 Mar 15;33(4):334-42
11246232
Glia. 2007 Jan 15;55(2):144-51
17078028
Glia. 2005 Apr 1;50(1):12-20
15599940
J Neurotrauma. 2009 Feb 11;26(2):155-77
19196079
Eur J Neurosci. 1999 Mar;11(3):769-80
10103071
Dev Biol. 1993 Feb;155(2):337-50
7679359
J Neurosci. 2007 Jul 4;27(27):7208-21
17611274
Brain Res. 2008 Nov 13;1240:31-8
18817757
Neurosci Lett. 2009 Jun 12;456(3):137-42
19429149
Stem Cells. 2009 Sep;27(9):2196-208
19544421
Glia. 2002 Mar 15;37(4):349-64
11870874
Glia. 1995 Jul;14(3):163-73
7591028
J Neurosci Res. 1997 Dec 1;50(5):665-72
9418955
Glia. 2004 Aug 1;47(2):130-7
15185392
Neuroscience. 1992;47(1):213-20
1374539
Exp Neurol. 2003 Nov;184(1):237-46
14637095
J Comp Neurol. 2007 Jul 10;503(2):209-23
17492622
Xenotransplantation. 2010 Jan-Feb;17(1):71-80
20149190
Dev Biol. 1996 Jan 10;173(1):327-43
8575633
Dev Biol. 1973 Jun;32(2):401-16
4789698
J Biophys Biochem Cytol. 1957 Nov 25;3(6):839-50
13481018
Glia. 2008 Apr;56(5):539-51
18240311
Brain Res. 1993 Jan 22;601(1-2):213-20
8431768
Int J Dev Biol. 1993 Jun;37(2):327-36
8398680
Mol Ther. 2010 Feb;18(2):394-403
19935779
Brain Res Rev. 2007 Nov;56(1):236-58
17884174
Methods Mol Biol. 2008;438:95-102
18369752
Glia. 2007 May;55(7):734-45
17348025
Glia. 2003 Mar;41(4):393-403
12555206
J Neurosci. 2007 Jul 4;27(27):7154-67
17611269
Glia. 2010 Jan 15;58(2):125-34
19606497
J Neurocytol. 1979 Feb;8(1):1-18
438867
Glia. 2006 Apr 15;53(6):649-59
16470843
Glia. 2003 Feb;41(3):224-36
12528178
Dev Biol. 1988 Oct;129(2):516-31
3417050
J Neurosci Res. 2001 Sep 15;65(6):520-8
11550220
Brain. 2000 Aug;123 ( Pt 8):1581-8
10908188
Glia. 1990;3(6):433-49
2148546
BMC Neurosci. 2007 Sep 18;8:74
17877797
J Neurosci Res. 2000 Jul 15;61(2):172-85
10878590
Neuron. 2000 Oct;28(1):15-8
11086978
Trends Neurosci. 2004 Jan;27(1):54-60
14698611
J Neurosci Res. 2000 Jun 1;60(5):571-8
10820427
Neuroscience. 1985 Jan;14(1):237-54
3974880
Brain. 2008 Sep;131(Pt 9):2376-86
18689435
Eur J Neurosci. 1993 Sep 1;5(9):1172-80
8281321