MicroRNAs and lung cancer: Biology and applications in diagnosis and prognosis.
MicroRNAs are tiny non-coding RNA molecules which play important roles in the epigenetic control of cellular processes by preventing the translation of proteins from messenger RNAs (mRNAs). A single microRNA can target different mRNAs, and an mRNA can be targeted by multiple microRNAs. Such complex interplays underlie many molecular pathways in cells, and specific roles for many microRNAs in physiological as well as pathological phenomena have been identified. Changes in expression of microRNAs have been associated with a wide variety of disease conditions, and microRNA-based biomarkers are being developed for the identification and monitoring of such states. This review provides a general overview of the current state of knowledge about the biology of microRNAs, and specific information about microRNAs with regard to the diagnosis and prognosis of lung cancer.
Mallick
Reema
R
Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA.
Patnaik
Santosh Kumar
SK
Yendamuri
Sai
S
J Clin Oncol. 2009 Apr 20;27(12):2030-7
19273703
BMC Mol Biol. 2009 Feb 22;10:12
19232136
Anal Chem. 2007 Sep 15;79(18):7192-7
17708676
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61
16461460
Nature. 2009 Dec 24;462(7276):1075-8
20010806
Ann Oncol. 2008 Jun;19(6):1053-9
18304967
Nat Cell Biol. 2008 Dec;10(12):1470-6
19011622
Cancer Res. 2009 Jul 1;69(13):5553-9
19549910
Nat Struct Mol Biol. 2006 Dec;13(12):1097-101
17099701
Nat Genet. 2005 May;37(5):495-500
15806104
RNA. 2004 Oct;10(10):1507-17
15383676
Biochem Biophys Res Commun. 2008 Sep 5;373(4):607-12
18602365
Cancer Cell. 2008 Jan;13(1):48-57
18167339
Clin Cancer Res. 2009 Sep 1;15(17):5473-7
19706812
J Thorac Oncol. 2007 Aug;2(8):706-14
17762336
Nature. 2000 Mar 16;404(6775):293-6
10749213
Nucleic Acids Res. 2009 May;37(8):2461-70
19255090
Cell Cycle. 2008 Aug 15;7(16):2601-8
18719372
Eur J Cancer. 2009 Aug;45(12):2197-206
19493678
Nat Struct Mol Biol. 2009 Sep;16(9):953-60
19684602
RNA. 2006 May;12(5):913-20
16540696
Nat Cell Biol. 2005 Jul;7(7):719-23
15937477
Eur Respir J. 2009 Feb;33(2):352-9
19010987
Urol Oncol. 2010 Nov-Dec;28(6):655-61
19375957
EMBO Rep. 2006 Sep;7(9):904-10
16906129
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24
19168627
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90
19597153
Lung Cancer. 2010 Feb;67(2):170-6
19446359
Cancer Cell. 2006 Mar;9(3):189-98
16530703
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
19474385
Cell. 2010 Jan 8;140(1):111-22
20085706
Methods Mol Biol. 2006;342:129-38
16957372
J Mol Diagn. 2008 Sep;10(5):415-23
18687792
Cancer Res. 2004 Jun 1;64(11):3753-6
15172979
Lung Cancer. 2007 Dec;58(3):392-6
17728006
Clin Cancer Res. 2010 Jan 15;16(2):430-41
20068076
Cell. 1993 Dec 3;75(5):843-54
8252621
J Biol Chem. 2009 Feb 27;284(9):5731-41
19073608
EMBO J. 2006 Feb 8;25(3):522-32
16424907
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10
17890317
Lung Cancer. 2009 Nov;66(2):169-75
19223090
Biosens Bioelectron. 2008 Dec 1;24(4):923-8
18799303
Nucleic Acids Res. 2005 Nov 27;33(20):e179
16314309
Clin Cancer Res. 2010 Jan 15;16(2):610-9
20068099
Cell. 2005 Nov 18;123(4):631-40
16271387
FASEB J. 2009 Sep;23(9):3243-50
19465468
Nat Cell Biol. 2007 Jun;9(6):654-9
17486113
Nat Biotechnol. 2008 Apr;26(4):462-9
18362881
Oncogene. 2008 Jun 19;27(27):3845-55
18246122
Nat Protoc. 2006;1(1):302-7
17406249
Gynecol Oncol. 2008 Jul;110(1):13-21
18589210
PLoS One. 2010 Feb 15;5(2):e9219
20169152
Cancer Res. 2010 Jan 1;70(1):36-45
20028859
Biochem Biophys Res Commun. 2009 Oct 16;388(2):177-80
19679101
CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
15761078
Chemistry. 2010 Jan 18;16(3):1010-6
19938021
Cell. 2007 Jun 29;129(7):1401-14
17604727
Oncology. 2009;76(3):162-9
19209007
Cancer Res. 2005 Nov 1;65(21):9628-32
16266980
EMBO J. 2004 Oct 13;23(20):4051-60
15372072
Mol Cell. 2007 Oct 26;28(2):328-36
17964270
Clin Cancer Res. 2009 Feb 15;15(4):1177-83
19228723
Cancer Res. 2009 Jul 15;69(14):5776-83
19584273
Cell. 2005 Jan 14;120(1):15-20
15652477
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
12434020
PLoS One. 2009 Jul 14;4(7):e6229
19597549
Nature. 2005 Aug 4;436(7051):740-4
15973356
Cell Res. 2008 Oct;18(10):997-1006
18766170
Clin Lung Cancer. 2009 Jan;10(1):42-6
19289371
BMC Res Notes. 2009 May 19;2:89
19454029
RNA Biol. 2007 Jun;4(2):76-84
17637574
Cancer Res. 2008 Oct 15;68(20):8535-40
18922928
Nat Methods. 2006 Jan;3(1):41-6
16369552
J Clin Invest. 2008 Jul;118(7):2600-8
18521189
Int J Cancer. 2010 Dec 15;127(12):2870-8
21351266
J Natl Compr Canc Netw. 2008 Mar;6(3):333-44
18377851
Genes Dev. 2003 Dec 15;17(24):3011-6
14681208
Biochem Biophys Res Commun. 2009 Oct 23;388(3):483-9
19654003
J Clin Oncol. 2010 Apr 1;28(10):1721-6
20194856
Cancer Cell. 2009 Dec 8;16(6):498-509
19962668
PLoS One. 2010 Mar 10;5(3):e9637
20224791
PLoS One. 2008;3(11):e3694
19002258
Oncogene. 2010 Mar 18;29(11):1580-7
19966857
Cell. 2006 Sep 22;126(6):1203-17
16990141
Science. 2001 Aug 3;293(5531):834-8
11452083
Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1183-7
19293314
Nat Struct Mol Biol. 2010 Jan;17(1):5-10
20051982