A preformed scleral search coil for measuring mouse eye movements.
Mice are excellent subjects for use of genetic-manipulation techniques to study the basis of pathological and normal physiology and behavior; however behavioral analyses of associated phenotypes is often limited. To improve the accuracy and specificity of repeated measurements of vestibular function, we developed a miniaturized, contact-lens scleral search coil to measure mouse eye movements. We describe the physical attributes and document its functionality by measuring vestibuloocular responses in normal mice. This coil should greatly improve the sensitivity and documentation of vestibular dysfunction in mouse models of pathology and dysfunction while allowing screening of significant numbers of subjects.
Kaneko
Chris R S
CR
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA. kaneko@uw.edu
Rosenfeld
Sam
S
Fontaine
Ethan
E
Markov
Alex
A
Phillips
James O
JO
Yarno
John
J
D000818:Animals; D003261:Contact Lenses; D053483:Eye Movement Measurements / Q000295:instrumentation*; D005133:Eye Movements / Q000502:physiology*; D051379:Mice; D012590:Sclera / Q000502:physiology*; D014741:Video Recording
J Neurophysiol. 1998 Feb;79(2):835-47
9463445
Optom Vis Sci. 1999 Jun;76(6):408-18
10416936
N Engl J Med. 2005 Apr 14;352(15):1557-64
15829536
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1516-21
17234811
Brain Res. 2003 May 16;972(1-2):75-83
12711080
Neuron. 2003 Sep 11;39(6):1031-42
12971901
Nat Rev Neurosci. 2002 Nov;3(11):896-902
12415297
Nat Genet. 1998 Aug;19(4):390-4
9697703
Hear Res. 2007 Feb;224(1-2):51-60
17208398
Eur J Neurosci. 2001 Oct;14(7):1129-42
11683905
Brain Res. 2001 Feb 2;890(2):296-305
11164796
Hear Res. 2004 May;191(1-2):34-40
15109702
J Biol Chem. 1998 Jul 24;273(30):18693-6
9668038
Neuroscience. 2000;95(3):903-11
10670457
J Neurosci Methods. 2000 Jun 30;99(1-2):101-10
10936649
J Med Genet. 2000 Aug;37(8):581-7
10922384
Exp Eye Res. 2003 Dec;77(6):731-9
14609561
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17078-82
12466504
Hematology. 2004 Aug;9(4):301-5
15621739
J Neurophysiol. 2004 May;91(5):2066-78
14724264
Genomics. 2001 Jun 1;74(2):228-33
11386759
Dev Dyn. 2002 Apr;223(4):517-25
11921339
Genetics. 1998 Oct;150(2):815-22
9755211
Laryngoscope. 2001 Jan;111(1):84-6
11192904
Neurosci Lett. 1999 May 28;267(2):93-6
10400220
Pharmacol Res. 1996 Feb;33(2):135-40
8870029
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7705-10
9636214