title: Field effect regulation of DNA translocation through a nanopore.
abstract: Field effect regulation of DNA nanoparticle translocation through a nanopore using a gate electrode is investigated using a continuum model, composed of the coupled Poisson-Nernst-Planck equations for the ionic mass transport and the Navier-Stokes equations for the hydrodynamic field. The field effect regulation of the DNA translocation relies on the induced electroosmotic flow (EOF) and the particle-nanopore electrostatic interaction. When the electrical double layers (EDLs) formed adjacent to the DNA nanoparticle and the nanopore wall are overlapped, the particle-nanopore electrostatic interaction could dominate over the EOF effect, which enables the DNA trapping inside the nanopore when the applied electric field is relatively low. However, the particle-nanopore electrostatic interaction becomes negligible if the EDLs are not overlapped. When the applied electric field is relatively high, a negative gate potential can slow down the DNA translocation by an order of magnitude, compared to a floating gate electrode. The field effect control offers a more flexible and electrically compatible approach to regulate the DNA translocation through a nanopore for DNA sequencing.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Old Dominion University, Norfolk, Virginia 23529, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ai
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Bingkai
authors.initials: B
authors.lastname: Zhang
authors.forename: Shizhi
authors.initials: S
authors.lastname: Qian
mesh_terms: D004247:DNA / Q000737:chemistry*; D004566:Electrodes; D053841:Electroosmosis; D057446:Hydrodynamics; D017136:Ion Transport; D053758:Nanoparticles / Q000737:chemistry; D058608:Nanopores; D017422:Sequence Analysis, DNA / Q000379:methods*; D055672:Static Electricity
chemical_list: D004247:DNA