Calcium, inorganic phosphates, alkaline and acid phosphatase activities in breast cancer patients in Calabar, Nigeria.
BACKGROUND
Breast cancer is the commonest malignancy of women in Nigeria. Change in serum levels of some biochemical parameters could assist diagnosis and follow-up of breast cancer.


OBJECTIVE
To determine serum levels of calcium, inorganic phosphates, alkaline phosphatase (ALP) and acid phosphatase (ACP) activities in patients with breast cancer, and change in the serum levels over time.


METHODS
Total serum calcium and inorganic phosphates, and serum ALP and ACP activities were determined in 25 women with breast cancer and 25 age-matched controls using colorimetric and enzymatic methods, over 6 months with bimonthly analysis.


RESULTS
The serum calcium level, ALP and ACP activities were significantly higher (p<0.05) in the study group than in the control group. No significant difference was seen in the inorganic phosphate levels of both groups. There were significant increases in serum calcium levels, ALP and ACP activities in the study group with time (p<0.05), whereas no significant increase was observed in the control group.


CONCLUSIONS
Breast cancer patients have higher calcium levels and higher ALP and ACP activities. The increase in the levels of these parameters with time shows that they could be of importance in monitoring treatment and disease progress in a resource-poor setting.
Usoro
Nathaniel I
NI
Surgery Department University of Calabar Teaching Hospital, Nigeria. natusoro@yahoo.com
Omabbe
Maxwell C
MC
Usoro
Chinyere A O
CA
Nsonwu
Augusta
A
D000135:Acid Phosphatase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000201:enzymology* / Q000473:pathology; D002118:Calcium / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006784:Hospitals, Teaching; D006801:Humans; D009549:Nigeria; D010710:Phosphates / Q000097:blood*
D010710:Phosphates; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002118:Calcium
Gan To Kagaku Ryoho. 2006 Feb;33(2):223-6
16484860
Cancer. 1989 Mar 15;63(6):1179-82
2645038
BMJ. 2000 Sep 9;321(7261):624-8
10977847
Clin Chim Acta. 2001 Feb;304(1-2):147-51
11165211
CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
15761078
J Biol Chem. 1953 Jan;200(1):89-97
13034762
Eur J Surg Oncol. 1998 Apr;24(2):139-42
9591031
Cancer Res. 1968 Jan;28(1):150-4
5635367
West Afr J Med. 2000 Jul-Sep;19(3):179-91
11126081
J Endocrinol Invest. 2001 May;24(5):315-20
11407650
BMC Fam Pract. 2001;2:2
11545676
World J Surg Oncol. 2006 Feb 21;4:11
16504034
Recent Prog Horm Res. 1986;42:705-50
3016837
Ann Intern Med. 1989 Nov 15;111(10):807-12
2817628
J Coll Physicians Surg Pak. 2006 Jan;16(1):49-52
16441990
Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):544-50
15701839
Clin Chim Acta. 1973 Jun 14;46(1):49-54
4732888
Am J Health Syst Pharm. 2001 Nov 15;58 Suppl 3:S4-7
11757205
N Engl J Med. 1992 Jul 30;327(5):319-28
1620171
Biochem J. 1932;26(2):292-7
16744823
Semin Oncol. 2000 Feb;27(1):34-44
10697020
Clin Exp Metastasis. 1993 Sep;11(5):359-67
8375111
Invasion Metastasis. 1995;15(3-4):116-24
8621267
Clin Lab. 2001;47(1-2):67-71
11214225