[Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke].
OBJECTIVE
To study the relationship between angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and the risk factor for essential hypertension (EH) with concurrent ischemic stroke in southern Chinese population.


METHODS
The G9570A polymorphism in ACE2 gene were detected in 139 patients with EH and stroke using polymerase chain reaction-restriction fragment length polymorphism. Detailed clinical and biochemistrical data of the patients, including the pulse pressure, high sensitivity C-reactive protein (hsCRP), intima-media thickness (IMT), high-density lipoprotein cholesterol (HDL-C) and uric acid levels, were collected to study the relationship between ACE2 gene and the risk factor of EH and stroke.


RESULTS
The levels of hsCRP (OR=1.022), uric acid (OR=1.224), IMT and pulse pressure was positively correlated to the incidence of EH and stroke. The pulse pressure, hsCRP, IMT, and HDL-C levels in male stroke patients carrying A allele was significantly higher than those in patients carrying G allele (P<0.05). In female stroke patients, the pulse pressure, hsCRP, IMT, and HDL-C levels were also significantly different with regard to the genotype of ACE2 gene (P<0.05).


CONCLUSIONS
The patients with EH and ischemic stroke carrying the A/AA allele of ACE2 gene have higher risks than those carrying other allele, and can be also more vulnerable to stroke recurrence.
Chen
Dong-li
DL
Department of Cardiology, Centrical Laboratory, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China. chendongliqq@163.com
Zhang
Cao-jin
CJ
Fu
Yong-heng
YH
Mo
Yu-jing
YJ
Chen
Fu-rong
FR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000085962:Angiotensin-Converting Enzyme 2; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2