Exploratory study on oxygen consumption on-kinetics during treadmill walking in women with systemic lupus erythematosus.
OBJECTIVE
To determine whether oxygen consumption (V o(2)) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls.


METHODS
Exploratory case-control study.


METHODS
Medical school exercise physiology laboratory.


METHODS
Convenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10).


METHODS
None.


METHODS
V o(2) on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs).


RESULTS
Time to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE.


CONCLUSIONS
V o(2) on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.
Keyser
Randall E
RE
George Mason University, Fairfax, VA, USA. rkeyser@gmu.edu
Rus
Violeta
V
Mikdashi
Jamal A
JA
Handwerger
Barry S
BS
D000328:Adult; D015308:Anaerobic Threshold; D016022:Case-Control Studies; D005080:Exercise Test; D017079:Exercise Tolerance; D005221:Fatigue / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology* / Q000534:rehabilitation*; D008875:Middle Aged; D010101:Oxygen Consumption
J Appl Physiol (1985). 1992 May;72(5):1764-72
1601784
J Appl Physiol (1985). 1996 Dec;81(6):2500-8
9018498
Eur J Appl Physiol Occup Physiol. 1975 Aug 15;34(3):141-8
1181176
J Lab Clin Med. 1969 Sep;74(3):369-79
4896818
J Appl Physiol (1985). 2008 Aug;105(2):575-80
18483168
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003534
16034902
J Appl Physiol (1985). 2007 Sep;103(3):771-8
17495116
Br J Sports Med. 2003 Aug;37(4):315-20
12893716
J Physiol. 2006 Dec 15;577(Pt 3):985-96
16990406
Exp Physiol. 2000 Jan;85(1):109-16
10662900
J Lab Clin Med. 1968 Jun;71(6):919-33
5654777
J Rheumatol. 2002 Mar;29(3):474-81
11908559
Med Sci Sports. 1979 Winter;11(4):338-44
530025
Arch Physiol Biochem. 2003 Dec;111(5):461-6
16026035
Aviat Space Environ Med. 1990 Mar;61(3):236-9
2317178
Arthritis Rheum. 2005 Dec 15;53(6):838-44
16342102
J Rheumatol. 1990 Nov;17(11):1450-2
2273484
J Appl Physiol (1985). 1995 Jun;78(6):2228-34
7665422
Med Sci Sports Exerc. 2002 Oct;34(10):1563-9
12370556
Am Heart J. 1973 Apr;85(4):546-62
4632004
J Rheumatol. 1999 Dec;26(12):2591-4
10606367
Rheumatology (Oxford). 2000 Nov;39(11):1249-54
11085805
Int J Tissue React. 1986;8(2):111-7
3700003
J Appl Physiol (1985). 2001 Aug;91(2):891-6
11457807
J Appl Physiol. 1971 Feb;30(2):261-3
5539892
Thorax. 1995 Aug;50(8):829-33
7570432
J Physiol. 2004 Dec 1;561(Pt 2):623-35
15358808
J Appl Physiol (1985). 2003 Dec;95(6):2537-43
14600163
J Appl Physiol (1985). 2005 Dec;99(6):2463-8; author reply 2468-9
16288106
Arch Phys Med Rehabil. 2003 Nov;84(11):1595-603
14639557
Arch Neurol. 1989 Oct;46(10):1121-3
2803071
Arthritis Rheum. 2003 Feb 15;49(1):16-22
12579589
Rheumatology (Oxford). 2003 Sep;42(9):1050-4
12730519
Sports Med. 1999 May;27(5):313-27
10368878
J Appl Physiol (1985). 2004 Mar;96(3):1033-8
14657038
Int J Sports Med. 2006 Jul;27(7):517-25
16802246
Circulation. 1987 Dec;76(6 Pt 2):VI18-28
3119250
Circulation. 1987 Dec;76(6 Pt 2):VI29-39
3315297
J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun;52(6):1506-13
6809716
Circulation. 1974 Apr;49(4):696-702
4817710
Med Sci Sports Exerc. 1996 Oct;28(10):1221-8
8897377
Med Sci Sports Exerc. 2010 Jan;42(1):127-34
20010121
Med Sci Sports Exerc. 2008 Mar;40(3):462-74
18379208
J Appl Physiol (1985). 2000 Sep;89(3):899-907
10956332
Aviat Space Environ Med. 1986 Jan;57(1):17-22
3942565
Diabetes Care. 1999 Oct;22(10):1640-6
10526728
J Clin Endocrinol Metab. 2004 Dec;89(12):6198-207
15579778
J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):921-9
6806226
J Rheumatol. 1995 Aug;22(8):1483-7
7473470
Arthritis Rheum. 2008 Jan;58(1):26-35
18163497
Med Sci Sports Exerc. 2003 Jul;35(7):1108-17
12840630
J Appl Physiol Respir Environ Exerc Physiol. 1978 Jan;44(1):90-2
627505
Arthritis Rheum. 2007 Dec 15;57(8):1348-57
18050225
Eur J Appl Physiol. 2004 May;91(5-6):545-54
14648126
Arthritis Rheum. 1982 Nov;25(11):1271-7
7138600
J Card Fail. 2001 Dec;7(4):302-10
11782852
Lupus. 2008 Feb;17(2):100-4
18250132
Eur J Appl Physiol Occup Physiol. 1991;63(2):94-100
1748111
J Rheumatol. 1990 Feb;17(2):210-9
2319520
Eur J Appl Physiol. 2004 May;91(5-6):669-76
14652761
J Appl Physiol (1985). 1986 Jun;60(6):2020-7
3087938
Med Sci Sports Exerc. 1994 Nov;26(11):1354-8
7837956
J Appl Physiol (1985). 2010 Apr;108(4):913-22
20150562
Med J Aust. 1964 Aug 22;2:320-1
14194486
Lab Invest. 1970 Apr;22(4):301-8
5429531
Med Sci Sports Exerc. 1994 Nov;26(11):1319-26
7741865
Hum Pathol. 1982 Aug;13(8):745-57
7049895
Chest. 1992 May;101(5 Suppl):211S-218S
1576837
Biophys J. 1990 Mar;57(3):485-98
2306498
Arch Phys Med Rehabil. 2003 Dec;84(12):1831-8
14669191
Med Sci Sports Exerc. 1995 Sep;27(9):1292-301
8531628
N Engl J Med. 1999 Jan 28;340(4):272-7
9920951
Eur Heart J. 1984 Sep;5(9):752-5
6499863