title: Short-range mechanical properties of skeletal and cardiac muscles.
abstract: Striated muscles are disproportionately stiff for small movements. This facet of their behavior can be demonstrated by measuring the force produced when the muscle is stretched more than about 1% of its initial length. When this is done, it can be seen that force rises rapidly during the initial phases of the movement and much less rapidly during the latter stages of the stretch. Experiments performed using chemically permeabilized skeletal and cardiac muscles show that the initial stiffness of the preparations increases in proportion with isometric force as the free Ca²(+) concentration in the bathing solution is raised from a minimal to a saturating value. This is strong evidence that the short-range mechanical properties of activated muscle result from stretching myosin cross-bridges that are attached between the thick and thin filaments. Relaxed intact muscles also exhibit short-range mechanical properties but the molecular mechanisms underlying this behavior are less clear. This chapter summarizes some of the interesting features of short-range mechanical properties in different types of muscle preparation, describes some of the likely underlying mechanisms and discusses the potential physiological significance of the behavior.
authors.affiliation: Department of Physiology & Center for Muscle Biology, University of Kentucky, Lexington, KY 40503, USA. k.s.campbell@uky.edu
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Campbell
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D006321:Heart / Q000502:physiology; D006706:Homeostasis; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology; D009126:Muscle Relaxation / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D018995:Myosin Heavy Chains / Q000502:physiology; D009218:Myosins / Q000378:metabolism; D051381:Rats; D012518:Sarcomeres / Q000502:physiology / Q000648:ultrastructure; D013314:Stress, Mechanical
chemical_list: D018995:Myosin Heavy Chains; D009218:Myosins; D002118:Calcium
references.citation: Pflugers Arch. 1976 Jun 29;364(1):71-6
references.pmid: 1085439
references.citation: J Biomech. 1996 May;29(5):627-33
references.pmid: 8707789
references.citation: J Muscle Res Cell Motil. 1999 Aug;20(5-6):433-42
references.pmid: 10555062
references.citation: J Mol Cell Cardiol. 2009 Jan;46(1):39-46
references.pmid: 19007786
references.citation: Biophys J. 2008 Jan 1;94(1):327-8; discussion 329-30
references.pmid: 17921211
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):759-69
references.pmid: 6629912
references.citation: Annu Rev Physiol. 1970;32:87-138
references.pmid: 4906128
references.citation: J Mol Cell Cardiol. 2000 Dec;32(12):2151-62
references.pmid: 11112991
references.citation: J Biomech. 1997 Nov-Dec;30(11-12):1179-82
references.pmid: 9456388
references.citation: Biophys J. 1994 Dec;67(6):2411-21
references.pmid: 7696481
references.citation: J Muscle Res Cell Motil. 2000 Apr;21(3):301-2
references.pmid: 10952178
references.citation: Prog Neurobiol. 1993 Dec;41(6):705-21
references.pmid: 8140258
references.citation: J Physiol. 2007 Oct 15;584(Pt 2):677-92
references.pmid: 17823208
references.citation: Biophys J. 2007 Sep 15;93(6):2102-9
references.pmid: 17513381
references.citation: Biophys J. 1995 Mar;68(3):1027-44
references.pmid: 7756523
references.citation: Biophys J. 2006 Dec 1;91(11):4102-9
references.pmid: 16950846
references.citation: J Physiol. 1984 Aug;353:265-85
references.pmid: 6481624
references.citation: Biophys J. 2003 Jun;84(6):3807-15
references.pmid: 12770886
references.citation: J Physiol. 1977 Jul;269(2):441-515
references.pmid: 302333
references.citation: J Physiol. 2002 Jun 1;541(Pt 2):335-42
references.pmid: 12042342
references.citation: J Gen Physiol. 1981 Oct;78(4):365-82
references.pmid: 6974762
references.citation: J Appl Physiol (1985). 2004 Jul;97(1):446-53
references.pmid: 15220325
references.citation: Proc Natl Acad Sci U S A. 1988 May;85(9):3265-9
references.pmid: 2966401
references.citation: J Physiol. 1992;451:503-23
references.pmid: 1403822
references.citation: N Engl J Med. 2004 May 6;350(19):1953-9
references.pmid: 15128895
references.citation: J Physiol. 1996 Nov 1;496 ( Pt 3):827-36
references.pmid: 8930847
references.citation: Biophys J. 2002 Jun;82(6):3118-27
references.pmid: 12023235
references.citation: Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2528-34
references.pmid: 15548726
references.citation: Biophys J. 1990 Feb;57(2):209-21
references.pmid: 2317547
references.citation: Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2857-64
references.pmid: 12907419
references.citation: Biophys J. 1994 Dec;67(6):2422-35
references.pmid: 7779179
references.citation: Acta Physiol Scand. 1981 Jun;112(2):113-20
references.pmid: 6976066
references.citation: J Physiol. 1990 Dec;431:141-71
references.pmid: 2100305
references.citation: Biophys J. 2002 Feb;82(2):929-43
references.pmid: 11806934
references.citation: J Physiol. 2001 Aug 15;535(Pt 1):279-88
references.pmid: 11507177
references.citation: Acta Physiol Scand. 2003 Dec;179(4):389-98
references.pmid: 14656377
references.citation: J Appl Physiol (1985). 1989 Jul;67(1):390-6
references.pmid: 2759968
references.citation: J Physiol. 1932 Apr 26;74(4):455-70
references.pmid: 16994291
references.citation: J Physiol. 1998 Aug 1;510 ( Pt 3):941-62
references.pmid: 9660904
references.citation: Pflugers Arch. 2008 Mar;455(6):995-1005
references.pmid: 17994251
references.citation: Am J Physiol. 1987 Sep;253(3 Pt 1):C484-93
references.pmid: 3631253
references.citation: Biophys J. 1998 Dec;75(6):2971-83
references.pmid: 9826617
references.citation: Am J Physiol Cell Physiol. 2004 Jun;286(6):C1353-7
references.pmid: 14749216
references.citation: J Physiol. 1968 Dec;199(3):637-84
references.pmid: 5710425
references.citation: Circ Res. 1994 Mar;74(3):408-15
references.pmid: 8118949
references.citation: J Appl Physiol (1985). 2001 May;90(5):1927-35
references.pmid: 11299287
references.citation: J Physiol. 1974 Jul;240(2):331-50
references.pmid: 4424163
references.citation: J Physiol. 2000 Jun 1;525 Pt 2:531-48
references.pmid: 10835052