MR water quantitative priors improves the accuracy of optical breast imaging.
Magnetic resonance (MR) guided optical breast imaging is a promising modality to improve the specificity of breast imaging, because it provides high-resolution quantitative maps of total hemoglobin, oxygen saturation, water content, and optical scattering. These properties have been shown to distinguish malignant from benign lesions. However, the optical detection hardware required for deep tissue imaging has poor spectral sensitivity which limits accurate water quantification; this reduces the accuracy of hemoglobin quantification. We present a methodology to improve optical quantification by utilizing the ability of Dixon MR imaging to quantitatively estimate water and fat; this technique effectively reduces optical crosstalk between water and oxyhemoglobin. The techniques described in this paper reduce hemoglobin quantification error by as much as 38%, as shown in a numerical phantom, and an experimental phantom. Error is reduced by as much 20% when imperfect MR water quantification is given. These techniques may also increase contrast between diseased and normal tissue, as shown in breast tissue in vivo. It is also shown that using these techniques may permit fewer wavelengths to be used with similar quantitative accuracy, enabling higher temporal resolution. In addition, it is shown that these techniques can improve the ability of MRI to quantify water in the presence of bias in the Dixon water/fat separation.
Carpenter
Colin M
CM
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA. colincarpenter@stanford.edu
Pogue
Brian W
BW
Jiang
Shudong
S
Wang
Jia
J
Hargreaves
Brian A
BA
Rakow-Penner
Rebecca
R
Daniel
Bruce L
BL
Paulsen
Keith D
KD
D001940:Breast / Q000737:chemistry / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D010108:Oxyhemoglobins / Q000032:analysis; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D014867:Water / Q000032:analysis
D006454:Hemoglobins; D010108:Oxyhemoglobins; D014867:Water; D010100:Oxygen
Opt Express. 2007 Jun 25;15(13):8043-58
19547132
J Biomed Opt. 2005 Sep-Oct;10(5):051504
16292948
Phys Med Biol. 2002 Aug 21;47(16):2847-61
12222850
Phys Med Biol. 2004 Apr 7;49(7):1165-81
15128196
Opt Lett. 2003 Dec 1;28(23):2339-41
14680175
Phys Med Biol. 2005 Jun 21;50(12):2837-58
15930606
IEEE Trans Med Imaging. 2009 Jan;28(1):30-42
19116186
Radiology. 2007 May;243(2):350-9
17400760
Appl Opt. 2003 Jun 1;42(16):3117-28
12790463
J Biomed Opt. 2002 Jan;7(1):72-9
11818014
J Biomed Opt. 2006 Jul-Aug;11(4):041102
16965130
Magn Reson Med. 2004 Jan;51(1):35-45
14705043
Appl Opt. 2005 Apr 1;44(10):1948-56
15813531
J Magn Reson Imaging. 2008 Dec;28(6):1483-91
19025936
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8828-33
16731633
Radiology. 2001 Jan;218(1):261-6
11152812
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12349-54
14514888
Technol Cancer Res Treat. 2003 Dec;2(6):563-9
14640767
J Biomed Opt. 2006 Jul-Aug;11(4):044005
16965162
Magn Reson Med. 1991 Apr;18(2):371-83
2046518
J Biomed Opt. 1997 Apr;2(2):147-53
23014867
Med Phys. 1993 Mar-Apr;20(2 Pt 1):299-309
8497214
Med Phys. 1995 Jun;22(6):691-701
7565358
Appl Opt. 1995 Dec 1;34(34):8026-37
21068901
J Biomed Opt. 2008 Jul-Aug;13(4):041305
19021313
Opt Lett. 2007 Apr 15;32(8):933-5
17375158
J Biomed Opt. 2000 Apr;5(2):221-8
10938787
Acad Radiol. 2005 Aug;12(8):934-47
16023382
J Magn Reson Imaging. 2008 Jan;27(1):192-7
18064714
Radiology. 1984 Oct;153(1):189-94
6089263
Adv Exp Med Biol. 2003;530:85-99
14562707
Phys Med Biol. 2004 Jun 21;49(12):N155-63
15272687
Radiology. 2008 Dec;249(3):1081
19011199
Appl Opt. 2005 Apr 10;44(11):2082-93
15835357
J Biomed Opt. 2009 Mar-Apr;14(2):024020
19405750
J Biomed Opt. 2002 Jan;7(1):60-71
11818013
Med Phys. 2007 Jun;34(6):2085-98
17654912
Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2767-72
10706610
Appl Opt. 2003 Sep 1;42(25):5181-90
12962399
J Magn Reson Imaging. 1995 Nov-Dec;5(6):695-701
8748488
Opt Express. 2008 Oct 27;16(22):17903-14
18958072