title: The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis.
abstract: BACKGROUND
  Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. Heterozygous carriers of ATM-mutations have an increased risk for the development of breast cancer. The purpose of this study is to evaluate the association between ATM exon39 5557G > A (D1853N, rs1801516) polymorphism and breast cancer susceptibility with the use of a meta-analysis.
  
  
  METHODS
  By searching PubMed and Embase databases, a total of 9 epidemiological studies with 4,191 cases and 3,780 controls were identified. Crude odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) for ATM D1853N polymorphism and breast cancer risk were calculated using fixed- or random-effects model based on the degree of heterogeneity among studies.
  
  
  RESULTS
  No significant association between the ATM D1853N polymorphism and breast cancer risk was observed in overall analysis (GA versus GG: OR = 1.18; 95% CI, 0.90-1.53; AA versus GG: OR = 0.77; 95% CI, 0.58-1.03; dominant model: OR = 1.16; 95% CI, 0.89-1.51; and recessive model: OR = 0.78; 95% CI, 0.59-1.04, respectively).
  
  
  CONCLUSIONS
  Our results indicate that ATM D1853N polymorphism is not a risk factor for developing breast cancer.
authors.affiliation: Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Lin-Bo
authors.initials: LB
authors.lastname: Gao
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Pan
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Rao
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Li
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Liang
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Lv
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases
references.citation: Stat Med. 2002 Jun 15;21(11):1539-58
references.pmid: 12111919
references.citation: Int J Radiat Biol. 1994 Dec;66(6 Suppl):S177-82
references.pmid: 7836845
references.citation: Nat Genet. 2006 Aug;38(8):873-5
references.pmid: 16832357
references.citation: DNA Repair (Amst). 2004 Aug-Sep;3(8-9):883-7
references.pmid: 15279773
references.citation: Cancer Res. 1994 Sep 1;54(17):4586-9
references.pmid: 8062246
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Am J Hum Genet. 2000 Feb;66(2):494-500
references.pmid: 10677309
references.citation: BMC Cancer. 2008 Apr 23;8:117
references.pmid: 18433505
references.citation: Genes Chromosomes Cancer. 1999 Jul;25(3):212-21
references.pmid: 10379867
references.citation: Med Oncol. 2011 Sep;28(3):733-7
references.pmid: 20396981
references.citation: Cancer Genet Cytogenet. 1996 Dec;92(2):130-4
references.pmid: 8976369
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Br J Cancer. 1999 Mar;79(7-8):1304-7
references.pmid: 10098776
references.citation: Breast Cancer Res Treat. 2011 Feb;125(3):827-35
references.pmid: 20640595
references.citation: Science. 1995 Jun 23;268(5218):1749-53
references.pmid: 7792600
references.citation: Nat Genet. 2007 Mar;39(3):352-8
references.pmid: 17293864
references.citation: Breast Cancer Res Treat. 2008 Jan;107(2):281-8
references.pmid: 17351744
references.citation: Cancer Res. 2001 Oct 15;61(20):7608-15
references.pmid: 11606401
references.citation: N Engl J Med. 1987 May 21;316(21):1289-94
references.pmid: 3574400
references.citation: N Engl J Med. 1991 Dec 26;325(26):1831-6
references.pmid: 1961222
references.citation: Mutat Res. 2000 Apr;462(2-3):167-78
references.pmid: 10767628
references.citation: Cancer Res. 1995 Jul 15;55(14):3003-7
references.pmid: 7606718
references.citation: Cancer. 2004 Apr 1;100(7):1345-51
references.pmid: 15042666
references.citation: Adv Cancer Res. 2001;83:209-54
references.pmid: 11665719
references.citation: Eur J Cancer. 2010 May;46(8):1333-43
references.pmid: 20400292
references.citation: Cancer Res. 1994 Dec 1;54(23):6270-4
references.pmid: 7954477
references.citation: Breast Cancer Res Treat. 2008 Jan;107(2):243-8
references.pmid: 17393301
references.citation: Genome Med. 2009 Jan 22;1(1):12
references.pmid: 19348699
references.citation: Breast Cancer Res Treat. 2011 Jan;125(2):571-4
references.pmid: 20640596
references.citation: Cancer Res. 1998 Apr 1;58(7):1376-9
references.pmid: 9537233
references.citation: BMC Cancer. 2006 Aug 16;6:209
references.pmid: 16914028
references.citation: Genes Chromosomes Cancer. 1990 Nov;2(4):339-40
references.pmid: 2268581
references.citation: Cancer Res. 2003 Dec 15;63(24):8717-25
references.pmid: 14695186
references.citation: J Cancer Res Clin Oncol. 2008 Aug;134(8):873-82
references.pmid: 18264724
references.citation: Int J Cancer. 2005 Aug 10;116(1):69-72
references.pmid: 15756685