title: Total colonoscopy detects early colorectal cancer more frequently than advanced colorectal cancer in patients with fecal occult blood.
abstract: The efficacy of total colonoscopy following a positive result of the fecal occult blood test (FOBT) for the early detection of colorectal cancer and polyps was evaluated. A total of 1,491 patients with positive FOBT results underwent total colonoscopy at the Institute of Gastroenterology, Nippon Medical School, Musashi Kosugi Hospital, from April 2002 through July 2009. Abnormalities were found in 1,312 of the 1,491 patients (88.0%). Ninety-six of the 1,491 patients (6.4%) were found to have early cancer, but 59 patients (4.0%) were found to have advanced cancer. The early cancers were treated with endoscopic mucosal resection or endoscopic submucosal dissection in 81 patients, with laparoscopy-assisted colectomy in 10 patients, and with open surgery in 5 patients. Fifty-one of the 59 patients with advanced colorectal cancer underwent conventional open surgery, and 8 patients underwent laparoscopic surgery. The cancers detected were more likely to be early cancers than advanced cancers. In addition to malignancies, other abnormalities found included inner or external hemorrhoids, diverticula of the colon, ulcerative colitis, ischemic colitis, infectious colitis, and colorectal polyps. Our results show that a high percentage of lesions detected with total colonoscopy following a positive FOBT result are early colorectal cancers and polyps.
authors.affiliation: Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Japan. Otakuji0128@aol.com
authors.forename: Takuji
authors.initials: T
authors.lastname: Ozaki
authors.forename: Akira
authors.initials: A
authors.lastname: Tokunaga
authors.forename: Naoto
authors.initials: N
authors.lastname: Chihara
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshino
authors.forename: Hideki
authors.initials: H
authors.lastname: Bou
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.forename: Masanori
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Eiji
authors.initials: E
authors.lastname: Uchida
mesh_terms: D017677:Age Distribution; D000368:Aged; D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009780:Occult Blood