title: Portal inflammation is associated with advanced histological changes in alcoholic and non-alcoholic fatty liver disease.
abstract: BACKGROUND
  Fatty liver disease (FLD), of either alcoholic (AFLD) or non-alcoholic (NAFLD) aetiologies, is characterised histologically by features that are lobulocentric that typically affect zone 3, in contrast with portal-based inflammation characteristics of other forms of chronic liver disease.
  
  
  OBJECTIVE
  The authors aimed to determine the prevalence and significance of portal inflammation in a cohort of adults diagnosed as having AFLD and NAFLD.
  
  
  METHODS
  From a histology database, the authors identified 160 patients with biopsy proven AFLD and 214 with NAFLD diagnosed between 1991 and 2001. All liver biopsies were reviewed by one pathologist to evaluate various histological features.
  
  
  RESULTS
  More than a mild degree of portal inflammation was found in 47% of AFLD compared with 30% in NAFLD subgroup. A higher degree of portal inflammation in AFLD was associated with a higher mean corpuscular volume, gamma glutamyl transferase (GGT) and alkaline phosphatase, and a lower platelet count and albumin, whereas in NAFLD this was associated with age, presence of diabetes, hypertension, body mass index (BMI), higher fasting blood glucose, cholesterol, alanine transaminase, GGT and ferritin. On regression analysis, portal inflammation was associated with the severity of steatosis (p=0.005), presence of ballooning (p=0.030) in NAFLD and severity of fibrosis in both AFLD and NAFLD (p<0.001).
  
  
  CONCLUSIONS
  Portal inflammation is a common component of histological spectrum of both AFLD and NAFLD. In both conditions portal inflammation is associated with clinical and histological features suggestive of advanced disease.
authors.affiliation: Department of Pathology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
authors.forename: Emad A
authors.initials: EA
authors.lastname: Rakha
authors.forename: Louise
authors.initials: L
authors.lastname: Adamson
authors.forename: Emily
authors.initials: E
authors.lastname: Bell
authors.forename: Keith
authors.initials: K
authors.lastname: Neal
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Ryder
authors.forename: Philip V
authors.initials: PV
authors.lastname: Kaye
authors.forename: Guruprasad P
authors.initials: GP
authors.lastname: Aithal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D015331:Cohort Studies; D005234:Fatty Liver / Q000150:complications* / Q000473:pathology; D005235:Fatty Liver, Alcoholic / Q000150:complications / Q000473:pathology; D005260:Female; D006521:Hepatitis, Chronic / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult