title: Examination of the offspring of a Japanese cow affected with L-type bovine spongiform encephalopathy.
abstract: The offspring of a beef cow affected with L-type bovine spongiform encephalopathy (L-BSE) was kept in a pen at a BSE-dedicated animal facility till the offspring was 48 months of age. The steer was then euthanized and subjected to a test for BSE. The abnormal isoform of the prion protein was not detected in the brain and spinal cord of the steer. Transmission of L-BSE was not observed during 4 years of observation, though the steer was born when the dam was in the terminal stages of the disease.
authors.affiliation: Prion Disease Research Center, National Institute of Animal Health, Ibaraki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Kentaro
authors.initials: K
authors.lastname: Masujin
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Iwamaru
authors.forename: Shirou
authors.initials: S
authors.lastname: Mohri
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D005260:Female; D008297:Male; D018620:PrPSc Proteins / Q000302:isolation & purification* / Q000378:metabolism; D013116:Spinal Cord / Q000473:pathology
chemical_list: D018620:PrPSc Proteins