Cyano Diels-Alder and cyano ene reactions. Applications in a formal [2 + 2 + 2] cycloaddition strategy for the synthesis of pyridines.
Two metal-free, formal [2 + 2 + 2] cycloaddition strategies for the construction of polycyclic pyridine derivatives are described that proceed via pericyclic cascade mechanisms featuring the participation of unactivated cyano groups as enophile and dienophile cycloaddition partners.
Sakai
Takeo
T
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Danheiser
Rick L
RL
D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D011725:Pyridines / Q000138:chemical synthesis*
D003486:Cyanides; D011725:Pyridines
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