title: In vivo femtosecond laser subsurface scleral treatment in rabbit eyes.
abstract: OBJECTIVE
  The progression of glaucoma can be reduced or delayed by reducing intraocular pressure (IOP). The properties of femtosecond laser surgery, such as markedly reduced collateral tissue damage, coupled with the ability to achieve isolated subsurface surgical effects in the sclera, make this technology a promising candidate in glaucoma management. In this pilot study we demonstrate the in vivo creation of partial thickness subsurface drainage channels with the femtosecond laser in the sclera of rabbit eyes in order to increase aqueous humor (AH) outflow.
  
  
  METHODS
  A femtosecond laser beam tuned to a 1.7 microm wavelength was scanned along a rectangular raster pattern to create the partial thickness subsurface drainage channels in the sclera of one eye of each of the four rabbits included in this pilot study. IOP was measured before and 20 minutes after the laser treatment to evaluate the acute effect of the procedure.
  
  
  RESULTS
  OCT images verified the creation of the partial thickness subsurface scleral channels in the eyes of the in vivo rabbits. Comparison of pre- and postoperative IOP measurements in treated and control eyes revealed a reduction in the intraocular pressure due to the increased rate of AH outflow resulted in by the presence of the partial thickness scleral channels.
  
  
  CONCLUSIONS
  The creation of partial thickness subsurface drainage channels was demonstrated in the sclera of in vivo rabbit eyes with a 1.7 microm wavelength femtosecond laser. Reduction in IOP achieved by the partial thickness channels suggests potential utility in the treatment of elevated IOP.
authors.affiliation: Department of Ophthalmology, University of California-Irvine, Irvine, California 92626, USA.
authors.forename: Dongyul
authors.initials: D
authors.lastname: Chai
authors.forename: Gautam
authors.initials: G
authors.lastname: Chaudhary
authors.forename: Eric
authors.initials: E
authors.lastname: Mikula
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.forename: Ron
authors.initials: R
authors.lastname: Kurtz
authors.forename: Tibor
authors.initials: T
authors.lastname: Juhasz
mesh_terms: D000818:Animals; D004322:Drainage / Q000379:methods; D005901:Glaucoma / Q000601:surgery*; D007429:Intraocular Pressure; D053685:Laser Therapy / Q000295:instrumentation*; D007834:Lasers; D011817:Rabbits; D012590:Sclera / Q000601:surgery*; D014130:Trabeculectomy / Q000295:instrumentation* / Q000379:methods
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