title: Treatment choice, duration, and cost in patients with interstitial cystitis and painful bladder syndrome.
abstract: OBJECTIVE
  In order to better understand provider treatment patterns for interstitial cystitis (IC)/painful bladder syndrome, we sought to document the therapies utilized and their associated expenditures using a national dataset.
  
  
  METHODS
  A cohort was created by applying the ICD-9 diagnosis of IC (595.1) to INGENIX claims for the year 1999. Subjects were followed for 5 years, and patterns of care and related expenditures were evaluated.
  
  
  RESULTS
  Of 553,910 adults insured in 1999, 89 subjects had a diagnosis of IC with 5-year follow-up data. All subjects were treated with oral medication(s), 26% received intravesical treatments, and 22% underwent hydrodistension. Total expenditures per subject were $2,808.
  
  
  CONCLUSIONS
  The majority of IC expenditures were attributable to oral medical therapy. Hydrodistension and intravesical instillations were utilized in less than 25% of patients. Hydrodistension was used more frequently among subjects with a new diagnosis; this may reflect its utilization as part of a diagnostic algorithm.
authors.affiliation: Department of Urology, UCLA, Box 951738, Los Angeles, CA 90095-1738, USA.
authors.forename: Jennifer T
authors.initials: JT
authors.lastname: Anger
authors.forename: Nasim
authors.initials: N
authors.lastname: Zabihi
authors.forename: J Quentin
authors.initials: JQ
authors.lastname: Clemens
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Payne
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Saigal
authors.forename: Larissa V
authors.initials: LV
authors.lastname: Rodriguez
mesh_terms: D000283:Administration, Intravesical; D000284:Administration, Oral; D018759:Adrenergic Uptake Inhibitors / Q000191:economics / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000588:Amines / Q000191:economics / Q000627:therapeutic use; D000639:Amitriptyline / Q000191:economics / Q000627:therapeutic use; D000925:Anticoagulants / Q000191:economics / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000191:economics / Q000627:therapeutic use; D018856:Cystitis, Interstitial / Q000188:drug therapy* / Q000191:economics; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000191:economics / Q000627:therapeutic use*; D009294:Narcotics / Q000191:economics / Q000627:therapeutic use*; D010426:Pentosan Sulfuric Polyester / Q000191:economics / Q000627:therapeutic use; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000191:economics / Q000627:therapeutic use
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000588:Amines; D000925:Anticoagulants; D003509:Cyclohexanecarboxylic Acids; D018727:Muscarinic Antagonists; D009294:Narcotics; D000639:Amitriptyline; D010426:Pentosan Sulfuric Polyester; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
references.citation: Urology. 2000 Dec 20;56(6):940-5
references.pmid: 11113737
references.citation: Arch Intern Med. 2007 Oct 8;167(18):1922-9
references.pmid: 17923590
references.citation: J Urol. 2000 Aug;164(2):423-7
references.pmid: 10893601
references.citation: Urology. 2005 Nov;66(5):935-40
references.pmid: 16286098
references.citation: Ann Chir Gynaecol Fenn. 1975;64(2):75-7
references.pmid: 1137336
references.citation: Urology. 1997 May;49(5A Suppl):64-75
references.pmid: 9146004
references.citation: Clin Obstet Gynecol. 2003 Dec;46(4):797-803
references.pmid: 14595221
references.citation: J Urol. 1999 Feb;161(2):553-7
references.pmid: 9915447
references.citation: J Urol. 2005 Nov;174(5):1837-40
references.pmid: 16217303
references.citation: Urology. 2005 Sep;66(3):494-9
references.pmid: 16140064
references.citation: Drug Saf. 2005;28(7):583-600
references.pmid: 15963006
references.citation: J Urol. 2007 Jun;177(6):2042-9
references.pmid: 17509284
references.citation: J Urol. 2004 Aug;172(2):533-6
references.pmid: 15247722
references.citation: South Med J. 2000 Feb;93(2):238-42
references.pmid: 10701800
references.citation: Int Braz J Urol. 2006 Sep-Oct;32(5):513-20
references.pmid: 17081319
references.citation: Urology. 2008 May;71(5):776-80; discussion 780-1
references.pmid: 18329077
references.citation: J Urol. 2003 Sep;170(3):810-5
references.pmid: 12913705
references.citation: Med Clin North Am. 2004 Mar;88(2):467-81, xii
references.pmid: 15049588
references.citation: J Urol. 2005 Aug;174(2):576-80
references.pmid: 16006901
references.citation: Urology. 1997 May;49(5A Suppl):2-9
references.pmid: 9145997