title: Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.
abstract: The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC(50)=0.006 μM) and good selectivity over HS27 fibroblast cell line.
authors.affiliation: Life/Health Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
authors.forename: Junsang
authors.initials: J
authors.lastname: Lee
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Nam
authors.forename: Hwan
authors.initials: H
authors.lastname: Kim
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
authors.forename: So Ha
authors.initials: SH
authors.lastname: Lee
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Cho
authors.forename: Tae Bo
authors.initials: TB
authors.lastname: Sim
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Hah
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Kim
authors.forename: Jinsung
authors.initials: J
authors.lastname: Tae
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000188:drug therapy; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002867:Chromones; D011799:Quinazolines