title: Prevalence of human papillomavirus genotypes in northern Taiwanese women.
abstract: The prevalence of Human Papillomavirus (HPV) in the general population of northern Taiwan is described. A total of 343 consecutive cervical swabs from women visiting the medical center for routine gynecologic care were included. Cervical cell cytology was examined by the Papanicolaou (Pap) test, and a PCR-based hybridization gene chip analysis was used to identify HPV genotypes. The HPV prevalence in the overall population was 32.4%. When divided into two groups according to cytology, 20.9% of women with normal cytology were HPV positive while 75.3% of women with abnormal cytology were HPV positive. Among positive samples, 68.5% were single type infections while 31.5% harbored multiple HPV types. A total of 32 types of HPV were identified; the leading five were HPV16 (5.8%), HPV58 (5.3%), HPV53 (4.1%), HPV52 (3.8%), and HPV18 (2.3%). Our results constitute baseline data and may provide important implications for future prophylactic programs. The relatively high prevalence of HPV 58, 53, and 52 among northern Taiwanese women has important implications for vaccine development.
authors.affiliation: Department of Laboratory Medicine, Lin-kou Chang Gung Memorial Hospital, Taoyuan, Taiwan. kctsao@adm.cgmh.org.tw
authors.forename: Kuo-Chien
authors.initials: KC
authors.lastname: Tsao
authors.forename: Chung-Guei
authors.initials: CG
authors.lastname: Huang
authors.forename: Yung-Bin
authors.initials: YB
authors.lastname: Kuo
authors.forename: Ting-Chang
authors.initials: TC
authors.lastname: Chang
authors.forename: Chien-Feng
authors.initials: CF
authors.lastname: Sun
authors.forename: C Allen
authors.initials: CA
authors.lastname: Chang
authors.forename: Su-Li
authors.initials: SL
authors.lastname: Yang
authors.forename: Err-Cheng
authors.initials: EC
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D004279:DNA, Viral