Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease.
Patterns of HIV-1 protease inhibitor (PI) resistance-associated mutations (RAMs) and effects on PI susceptibility associated with the L76V mutation were studied in a large database. Of 20,501 sequences with ≥1 PI RAM, 3.2% contained L76V; L76V was alone in 0.04%. Common partner mutations included M46I, I54V, V82A, I84V, and L90M. L76V was associated with a 2- to 6-fold decrease in susceptibility to lopinavir, darunavir, amprenavir, and indinavir and a 7- to 8-fold increase in susceptibility to atazanavir and saquinavir.
Young
Thomas P
TP
Abbott Molecular, 1300 East Touhy Avenue, Des Plaines, IL 60018-3315, USA. tom.young@abbott.com
Parkin
Neil T
NT
Stawiski
Eric
E
Pilot-Matias
Tami
T
Trinh
Roger
R
Kempf
Dale J
DJ
Norton
Michael
M
D000998:Antiviral Agents / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology; D000069454:Darunavir; D005663:Furans; D016333:HIV Protease / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D019469:Indinavir / Q000493:pharmacokinetics; D061466:Lopinavir; D009154:Mutation; D011744:Pyrimidinones / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology
D000998:Antiviral Agents; D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D013449:Sulfonamides; D061466:Lopinavir; C095108:amprenavir; D019469:Indinavir; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1; D000069454:Darunavir
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