Plant DNA recombinases: a long way to go.
DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity. DNA recombinases, a special group of proteins bind to single stranded DNA (ssDNA) nonspecifically and search the double stranded DNA (dsDNA) molecule for a stretch of DNA that is homologous with the bound ssDNA. Recombinase A (RecA) has been well characterized at genetic, biochemical, as well as structural level from prokaryotes. Two homologues of RecA called Rad51 and Dmc1 have been detected in yeast and higher eukaryotes and are known to mediate the homologous recombination in eukaryotes. The biochemistry and mechanism of action of recombinase is important in understanding the process of homologous recombination. Even though considerable progress has been made in yeast and human recombinases, understanding of the plant recombination and recombinases is at nascent stage. Since crop plants are subjected to different breeding techniques, it is important to know the homologous recombination process. This paper focuses on the properties of eukaryotes recombinases and recent developments in the field of plant recombinases Dmc1 and Rad51.
Chittela
Rajani Kant
RK
Plant Biochemistry Section, Molecular Biology Division, Bhabha Atomic Research Center, Trombay, Mumbai 400 085, India.
Sainis
Jayashree K
JK
Plant J. 2001 Jan;25(1):31-41
11169180
DNA Res. 1994;1(1):15-26
7584025
Oncogene. 1996 May 16;12(10):2165-70
8668342
Genetics. 1991 May;128(1):163-73
1648001
Mol Cell. 2001 Feb;7(2):273-82
11239456
Science. 1993 Mar 26;259(5103):1896-9
8456314
J Biol Chem. 1997 Jul 11;272(28):17675-85
9211918
J Mol Biol. 1990 Nov 20;216(2):335-52
2147722
Chromosoma. 2002 Jul;111(2):96-105
12111332
Nat Genet. 1993 Jul;4(3):239-43
8358431
Plant Physiol. 2005 Oct;139(2):896-908
16169964
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11221-6
9326590
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):463-8
9012806
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11731-5
9326679
EMBO J. 2000 Dec 15;19(24):6675-85
11118202
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8537-42
15937124
Nature. 2002 Nov 21;420(6913):287-93
12442171
Nucleic Acids Res. 1998 Apr 1;26(7):1653-9
9512535
Genetics. 1992 Oct;132(2):553-66
1330826
Mol Cell. 2004 May 7;14(3):363-74
15125839
Plant Mol Biol. 1995 May;28(2):281-92
7599313
Microbiol Mol Biol Rev. 2002 Dec;66(4):630-70, table of contents
12456786
Plant Physiol. 2005 Jun;138(2):965-76
15923332
Plant Mol Biol. 2008 Nov;68(4-5):479-91
18695945
Plant Cell. 1999 May;11(5):809-24
10330467
Annu Rev Genet. 2001;35:53-82
11700277
J Mol Biol. 1988 Mar 20;200(2):329-49
3373533
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8433-9
11459986
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6577-80
8341671
Chromosoma. 2003 Jul;112(1):17-25
12811575
Proc Natl Acad Sci U S A. 1979 Jan;76(1):126-30
370822
Plant Mol Biol. 2005 Jan;57(1):1-11
15821864
J Biol Chem. 1993 Jan 15;268(2):1292-7
8419331
DNA Repair (Amst). 2006 Jan 5;5(1):1-12
16202663
Proc Natl Acad Sci U S A. 1965 Feb;53:451-9
14294081
Cell. 1996 Nov 15;87(4):757-66
8929543
EMBO Rep. 2001 Apr;2(4):287-91
11306548
J Mol Biol. 2002 Feb 8;316(1):35-49
11829501
Nature. 1992 Jan 23;355(6358):318-25
1731246
FEBS J. 2006 Apr;273(7):1497-506
16689935
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2959-64
11880641
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8189-95
11459952
Biochim Biophys Acta. 1996 Jul 24;1312(3):231-6
8703992
J Biol Chem. 2000 Feb 11;275(6):3970-6
10660552
EMBO J. 1999 Nov 15;18(22):6552-60
10562567
Trends Biochem Sci. 2001 Feb;26(2):131-6
11166572
Cell. 1995 Aug 11;82(3):453-61
7634335
Genetics. 1997 May;146(1):401-7
9136028
Plant Cell. 1995 Dec;7(12):2151-61
8718625
Genetics. 1995 Aug;140(4):1389-406
7498778
Nucleic Acids Res. 1993 Apr 11;21(7):1665
8479919
DNA Res. 1995;2(2):89-93
7584052
Mol Cell. 1998 Apr;1(5):697-705
9660953
J Biol Chem. 2001 Nov 9;276(45):41906-12
11551925
Mol Gen Genet. 1998 Feb;257(3):283-91
9520262
Mol Cell. 1998 Apr;1(5):707-18
9660954
Plant J. 1997 Jan;11(1):1-14
9025299
J Mol Biol. 1985 Sep 20;185(2):295-309
4057248
EMBO J. 1991 Jun;10(6):1571-8
2026150
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10684-8
10485886
Genesis. 2000 Mar;26(3):167-73
10705376
Microbiol Rev. 1994 Sep;58(3):401-65
7968921
Trends Genet. 2005 Mar;21(3):172-81
15734576
EMBO J. 2000 Mar 1;19(5):1148-56
10698955
Plant Mol Biol. 2005 Apr;57(6):819-33
15952068
Genes Dev. 1995 Apr 15;9(8):925-34
7774810
J Mol Biol. 1999 Nov 5;293(4):769-80
10543966
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1711-6
11172016
J Mol Biol. 1985 Jan 20;181(2):281-95
3981638
J Biol Chem. 2003 Jan 24;278(4):2469-78
12427746
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8000-4
11607492
Nature. 2004 May 27;429(6990):433-7
15164066
EMBO J. 1994 Jan 15;13(2):484-9
8313893
J Biol Chem. 2005 Dec 9;280(49):40980-4
16204247
Trends Biochem Sci. 1998 Jul;23(7):247-51
9697414
Mol Cell. 1998 May;1(6):783-93
9660962
EMBO J. 1990 Oct;9(10):3077-84
2209538
Prog Nucleic Acid Res Mol Biol. 1981;26:265-79
7025096
EMBO J. 1994 Dec 1;13(23):5764-71
7988572
Plant J. 1997 Jun;11(6):1195-206
9225463
Plant J. 2004 Jun;38(6):954-68
15165187
Plant Mol Biol. 2007 Sep;65(1-2):31-42
17562186
Plant Cell. 1992 Mar;4(3):319-332
12297648
Mutat Res. 2004 Mar;566(2):131-67
15164978
Curr Genet. 1997 Feb;31(2):144-57
9021132
Biochim Biophys Acta. 1998 Jul 9;1398(3):353-8
9655934
Mutat Res. 2002 Nov 30;509(1-2):49-78
12427531
Mol Cell Biol. 1997 Dec;17(12):7151-8
9372947
DNA Repair (Amst). 2006 Mar 7;5(3):381-91
16388992
Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7417-22
9207106
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10596-601
15249667
EMBO J. 1990 Nov;9(11):3437-45
2170114
Nucleic Acids Res. 1996 Feb 1;24(3):470-7
8602360
Genetics. 1966 Jun;53(6):1137-50
5335129
Plant Cell. 1999 Sep;11(9):1623-34
10488231
Science. 1994 Aug 26;265(5176):1241-3
8066464
Nucleic Acids Res. 2008 Aug;36(13):4266-76
18583359
Mol Cell Biol. 1999 Dec;19(12):8686-93
10567591
Cell. 1992 May 1;69(3):457-70
1581961
Nucleic Acids Res. 1998 Mar 1;26(5):1179-84
9469824
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10477-81
9724728
Nature. 1992 Jan 23;355(6358):374-6
1731253
Plant Cell. 2003 Aug;15(8):1807-16
12897254
Nat Rev Genet. 2008 Jan;9(1):27-37
18040271
Proc Natl Acad Sci U S A. 1985 Jan;82(2):297-301
2982147
Mol Cell Biol. 1996 Dec;16(12):7133-43
8943369
J Mol Biol. 1986 Oct 20;191(4):677-97
2949085
Genomics. 1997 Dec 15;46(3):476-9
9441753
Cell. 1992 May 1;69(3):439-56
1581960
Biochemistry. 1989 Feb 7;28(3):1062-9
2523733
Plant J. 2005 Feb;41(4):533-45
15686518
J Biol Chem. 2001 Mar 23;276(12):8798-806
11124265
Plant Physiol. 2006 Mar;140(3):1059-69
16415210
Mol Cell Biol. 1992 Jul;12(7):3235-46
1620128
Biochemistry. 2005 Apr 26;44(16):6052-8
15835894
Nat Struct Mol Biol. 2004 Aug;11(8):791-6
15235592