[Antiviral activity of 2,3-secotriterpenic hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type].
Novel hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type have been synthesized via interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of investigation of 2,3-secotriterpenic hydrazones antiviral activity to the strain "Indiana" of vesicular stomatitis virus on two models of mammal's line cell infection, acetylhydrazone 1-cyano-2,3-seco-19beta,28-epoxy-18alpha-olean-3-al has been found to have a high prophylactic activity 0.00016 microg/ml to vesicular stomatitis virus and to inhibit a virus reproduction in primarily infected cells in 0.21 microg/ml concentration.
Galaĭko
N V
NV
Tolmacheva
I A
IA
Grishko
V V
VV
Volkova
L V
LV
Prevozchikova
E N
EN
Pestereva
S A
SA
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D018353:Rhabdoviridae Infections / Q000188:drug therapy*; D013552:Swine; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus; D053978:Pentacyclic Triterpenes
D000998:Antiviral Agents; D006835:Hydrazones; D009828:Oleanolic Acid; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes