[Delayed influenza mortality in elderly persons].
OBJECTIVE
Analysis of influenza morbidity and mortality including delayed mortality as well as study of the association between increased mortality in elderly and influenza incidence.


METHODS
Epidemiologic methods of research as well as reporting forms No. 2 and C51 for Moscow for the period 1999-2005 were used. Analysis was performed for 28,801,565 cases of influenza illness as well as for 41,310 fatal cases, of which 6048 cases due to cardiovascular and respiratory diseases were extracted. Retrospective epidemiologic analysis of perennial and within-year incidence of influenza and mortality due to mentioned diseases in Moscow was performed. Correlation analysis was done using Spearman rank correlation coefficient and Pearson correlation coefficient.


RESULTS
Delayed mortality concept was introduced. Existence of delayed mortality after influenza illness in persons >60 year old with ischemic heart disease, acute myocardial infarction and cerebrovascular disease was proved. It was established that vaccination against influenza in persons aged >60 years with underlying cardiovascular diseases during epidemic season could prevent 246 deaths each year.


CONCLUSIONS
Delayed mortality was detected only in patients with cardiovascular diseases, whereas in patients with respiratory diseases direct complications due to influenza developed. Influenza immunization of elderly persons could yield marked economic effect as cost of treatment of one case of acute myocardial infarction or attack of cerebrovascular disease is significantly higher than cost of vaccination.
Saltykova
T S
TS
D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000821:virology; D015897:Comorbidity; D006801:Humans; D007251:Influenza, Human / Q000150:complications / Q000401:mortality*; D008875:Middle Aged; D009031:Moscow / Q000453:epidemiology; D012307:Risk Factors; D014611:Vaccination