title: A new commercially viable synthetic route for donepezil hydrochloride: anti-Alzheimer's drug.
abstract: An economical new process has been developed for the synthesis of donepezil hydrochloride (1) an anti-Alzheimer's drug. The process involves Darzen reaction of pyridine-4-carboxaldehyde and 2-bromo-5,6-dimethoxy indanone affording epoxide 5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one (4) as a key intermediate. The one-pot deoxygenation of 4 and hydrogenation of the aryl moiety in high yield improved the overall yield of the process.
authors.affiliation: Chemical and Pharma Research Department, Jubilant Organosys Limited, Cairo 11562, Egypt.
authors.forename: Shailendra Kumar
authors.initials: SK
authors.lastname: Dubey
authors.forename: Manita
authors.initials: M
authors.lastname: Kharbanda
authors.forename: Sushil Kumar
authors.initials: SK
authors.lastname: Dubey
authors.forename: Chandra Shekhar
authors.initials: CS
authors.lastname: Mathela
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000077265:Donepezil; D006801:Humans; D007189:Indans / Q000138:chemical synthesis*; D018697:Nootropic Agents / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical / Q000191:economics / Q000379:methods*
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil