Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats.
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
Doi
Maho
M
Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Detistry and Pharmaceucial Sciences, and Department of Pharmacy, Okayama University Hospital, Okayama 760-8530, Japan.
Miyazaki
Ikuko
I
Nagamachi
Tomoko
T
Shinomiya
Kazuaki
K
Matsunaga
Hisashi
H
Sendo
Toshiaki
T
Kawasaki
Hiromu
H
Asanuma
Masato
M
Gomita
Yutaka
Y
Kitamura
Yoshihisa
Y
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D018692:Antimanic Agents / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D018891:Dentate Gyrus / Q000166:cytology* / Q000187:drug effects; D003863:Depression / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D007099:Imipramine / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology
D000929:Antidepressive Agents, Tricyclic; D018692:Antimanic Agents; D012965:Sodium Chloride; D000324:Adrenocorticotropic Hormone; D008094:Lithium; D007099:Imipramine