title: Regret and the negative evaluation of decision outcomes in major depression.
abstract: Disruption of normal emotional experience is central to the phenomenology of depression. Twenty-three depressed outpatients and 23 control subjects performed a computerized decision-making task, during which affective ratings were assessed online to identify various dimensions of emotional experience. We sought to contrast regret (the comparison of the outcomes of selected and nonselected options) with the general negative appraisal of task events. The experience of regret was reduced in depressed patients, an effect that was particularly related to self-reported apathy scores. In an exploratory analysis, we observed that females had a general downward shift in their ratings, as compared with males, but disappointment and regret effects were of similar magnitude. The possible contribution of the orbitofrontal cortex to the phenomenology of regret is discussed. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.
authors.affiliation: University of Cambridge, Cambridge, England. henry.chase@nottingham.ac.uk
authors.forename: Henry W
authors.initials: HW
authors.lastname: Chase
authors.forename: Nathalie
authors.initials: N
authors.lastname: Camille
authors.forename: Albert
authors.initials: A
authors.lastname: Michael
authors.forename: Edward T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Robbins
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Sahakian
mesh_terms: D000339:Affect; D000704:Analysis of Variance; D057565:Apathy; D016022:Case-Control Studies; D003657:Decision Making; D003866:Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D010865:Pilot Projects; D012016:Reference Values; D012054:Reinforcement, Psychology; D012647:Self-Assessment; D012718:Set, Psychology; D012737:Sex Factors
references.citation: Arch Gen Psychiatry. 1961 Jun;4:561-71
references.pmid: 13688369
references.citation: Biol Psychiatry. 2005 Feb 15;57(4):319-27
references.pmid: 15705346
references.citation: Cereb Cortex. 2006 Jul;16(7):916-28
references.pmid: 16207933
references.citation: Arch Gen Psychiatry. 2008 Feb;65(2):179-88
references.pmid: 18250256
references.citation: J Affect Disord. 2009 Nov;118(1-3):69-78
references.pmid: 19261334
references.citation: Psychol Bull. 2000 Nov;126(6):910-24
references.pmid: 11107882
references.citation: Neuropsychopharmacology. 1999 Apr;20(4):322-39
references.pmid: 10088133
references.citation: Psychiatry Res. 1991 Aug;38(2):143-62
references.pmid: 1754629
references.citation: Brain Struct Funct. 2009 Oct;213(6):535-51
references.pmid: 19760243
references.citation: Brain Res Cogn Brain Res. 2005 Aug;24(3):723-6
references.pmid: 16099374
references.citation: J Behav Ther Exp Psychiatry. 2008 Dec;39(4):567-76
references.pmid: 18342834
references.citation: Trends Cogn Sci. 2007 Jun;11(6):258-65
references.pmid: 17475537
references.citation: J Neurosci. 2008 Nov 19;28(47):12341-8
references.pmid: 19020027
references.citation: Psychol Bull. 1997 Jan;121(1):133-48
references.pmid: 9000895
references.citation: Neuropsychologia. 2005;43(8):1214-21
references.pmid: 15817179
references.citation: Brain. 2008 Aug;131(Pt 8):2084-93
references.pmid: 18579575
references.citation: Semin Clin Neuropsychiatry. 1996 Oct;1(4):304-314
references.pmid: 10320433
references.citation: Science. 2004 May 21;304(5674):1167-70
references.pmid: 15155951
references.citation: J Consult Clin Psychol. 1988 Dec;56(6):893-7
references.pmid: 3204199
references.citation: Br J Psychiatry. 1979 Apr;134:382-9
references.pmid: 444788
references.citation: Am J Psychiatry. 2009 Jun;166(6):702-10
references.pmid: 19411368
references.citation: Am J Psychiatry. 2007 Apr;164(4):608-16
references.pmid: 17403974
references.citation: Biol Psychiatry. 2008 Apr 1;63(7):686-92
references.pmid: 17916330
references.citation: Psychol Med. 2010 Mar;40(3):433-40
references.pmid: 19607754
references.citation: Brain. 2007 Sep;130(Pt 9):2367-74
references.pmid: 17586866
references.citation: J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):314-9
references.pmid: 9706539
references.citation: Psychol Sci. 2004 May;15(5):325-30
references.pmid: 15102142
references.citation: Nat Neurosci. 2005 Sep;8(9):1255-62
references.pmid: 16116457
references.citation: Psychol Med. 2001 May;31(4):679-93
references.pmid: 11352370