Synthesis and characterization of chitosan hydrogels containing 5-aminosalicylic acid nanopendents for colon: specific drug delivery.
The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated for particle size, encapsulation efficiency, swellability, and in vitro drug release. The size of the hydrogel was found to nanorange. The integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The CS-Ac-PAMAM hydrogel was developed based on the modulation of ratio show promise as a system for controlled delivery of drug.
Saboktakin
Mohammad Reza
MR
Nanostructured Materials Synthesis Lab., International Research Institute of Arian Chemie Gostar, Tabriz, Iran. saboktakin123@yahoo.com
Tabatabaie
Roya M
RM
Maharramov
Abel
A
Ramazanov
Mohammad Ali
MA
D010131:Aminosalicylic Acid / Q000008:administration & dosage*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry*; D003106:Colon / Q000378:metabolism*; D016503:Drug Delivery Systems; D004591:Electrophoresis, Polyacrylamide Gel; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010316:Particle Size
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D010131:Aminosalicylic Acid; D048271:Chitosan