title: Our clinical experience about prenatal diagnosis and neonatal outcomes of fetal central nervous system anomalies.
abstract: OBJECTIVE
  To present a retrospective analysis of the prenatal diagnosis and the outcome of fetuses diagnosed with central nervous system (CNS) anomalies.
  
  
  METHODS
  We reviewed the medical records and ultrasound data of 69 cases diagnosed with CNS anomalies from 2007 to 2008. We described the prenatal diagnosis, associated findings, and outcome of these patients.
  
  
  RESULTS
  Sixty-nine patients were diagnosed with CNS anomalies. Of these, 31 had ventriculomegaly + hydrocephaly, 14 had spina bifida + meningomyelosel, 5 had choroid plexus cyst, 5 had Dandy Walker malformation, 3 had sacrocoxigeal teratoma, 2 had encephalosel, 1 had microcephaly, and 1 had Arnold Chiari malformation. Eight amniocentesis, three cord blood sampling, and two fetal reduction procedure were performed. Nine pregnancy termination and 36 delivery were performed. Neurosurgical correction was performed for neonates with spina bifida, hydrocephaly and sacrocoxigeal teratoma. Twenty-one neonates were discharged with cure, 4 neonates with follow-up, 7 neonates with paraplegia, and 13 neonates died.
  
  
  CONCLUSIONS
  The outcome of fetuses with CNS anomalies was shown to depend mainly on the degree of neural tube defect and the associated anomalies were the most important factors in surviving.
authors.affiliation: Department of Obstetric and Gynecology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. zehrasema@yahoo.com
authors.forename: Zehra Sema
authors.initials: ZS
authors.lastname: Ozkan
authors.forename: Hasan
authors.initials: H
authors.lastname: Gilgin
authors.forename: Hatice Banu
authors.initials: HB
authors.lastname: Aygün
authors.forename: Derya
authors.initials: D
authors.lastname: Deveci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Simşek
authors.forename: Selahattin
authors.initials: S
authors.lastname: Kumru
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Yüce
mesh_terms: D000293:Adolescent; D000328:Adult; D002490:Central Nervous System / Q000002:abnormalities* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000209:etiology; D009421:Nervous System Malformations / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000401:mortality; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D055815:Young Adult