Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0·005). Similar associations were seen with the double-strand break repair (P = 0·02) and nucleotide excision repair (P = 0·04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP ≤ 0·05), or because of high level of statistical significance (P ≤ 0·005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.
Shen
Min
M
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
Menashe
Idan
I
Morton
Lindsay M
LM
Zhang
Yawei
Y
Armstrong
Bruce
B
Wang
Sophia S
SS
Lan
Qing
Q
Hartge
Patricia
P
Purdue
Mark P
MP
Cerhan
James R
JR
Grulich
Andrew
A
Cozen
Wendy
W
Yeager
Meredith
M
Holford
Theodore R
TR
Vajdic
Claire M
CM
Davis
Scott
S
Leaderer
Brian
B
Kricker
Anne
A
Severson
Richard K
RK
Zahm
Shelia H
SH
Chatterjee
Nilanjan
N
Rothman
Nathaniel
N
Chanock
Stephen J
SJ
Zheng
Tongzhang
T
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D004273:DNA, Neoplasm
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