Mucin core protein expression in serrated polyps of the large intestine.
Sessile serrated adenoma (SSA) has been proposed as a precursor to microsatellite-unstable colorectal carcinoma. However, histological criteria dictating how to differentiate serrated lesions have not been completely established, and a histological overlap exists between SSA and hyperplastic polyps (HPs), particularly the microvesicular type. In this study, based on a critical review of histology, we aimed to elucidate the potential utility of the mucin phenotype in the identification of SSA. We evaluated mucin core protein expression (MUC2, MUC5AC, and MUC6) by immunohistochemical stain in 65 cases of microvesicular-type HPs, 51 SSAs, and 72 traditional serrated adenomas (TSAs). SSAs had clinicopathological and morphological features distinct from those of HPs and TSAs. MUC6 was more frequently positive in SSAs (39%) than in TSAs (4%) and HPs (19%) (P < 0.001 and P = 0.0107, respectively). Right-sided HPs more frequently expressed MUC6 than did left-sided HPs (60% vs. 4%, respectively; P < 0.0001), but SSAs and TSAs showed no regional differences. These findings suggest that determination of mucin core protein expression is insufficient for differentiating SSAs from other types of serrated polyps, and that microvesicular-type HPs of the right colon and SSAs may belong to the same mucin spectrum.
Fujita
Kohei
K
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Hirahashi
Minako
M
Yamamoto
Hidetaka
H
Matsumoto
Takayuki
T
Gushima
Masaki
M
Oda
Yoshinao
Y
Kishimoto
Junji
J
Yao
Takashi
T
Iida
Mitsuo
M
Tsuneyoshi
Masazumi
M
D000236:Adenoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000737:chemistry* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC / Q000032:analysis; D055262:Mucin-2 / Q000032:analysis; D055272:Mucin-6 / Q000032:analysis; D009077:Mucins / Q000032:analysis*; D012189:Retrospective Studies
C524625:MUC2 protein, human; C524678:MUC5AC protein, human; C524734:MUC6 protein, human; D055271:Mucin 5AC; D055262:Mucin-2; D055272:Mucin-6; D009077:Mucins
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