title: Phenolic dimers and an indole alkaloid from Campylospermum flavum (Ochnaceae).
abstract: From the leaves and stem bark of Campylospermum flavum (Ochnaceae), three compounds, namely 4‴-O-methylagathisflavone, flavumchalcone, and flavumindole have been isolated together with 10 known compounds, including three flavonoids, two biflavonoids, two alkaloids, two nitrile glucosides, and glucopyranosyl-β-sistosterol. The structures of these compounds and their relative configurations were established by 1D and 2D NMR experiments. The methanolic crude extracts of leaves and stem bark of C. flavum and compounds displayed a significant cytotoxicity towards Artemia salina larvae.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon.
authors.forename: Joseph Thierry
authors.initials: JT
authors.lastname: Ndongo
authors.forename: Mohamed
authors.initials: M
authors.lastname: Shaaban
authors.forename: Joséphine Ngo
authors.initials: JN
authors.lastname: Mbing
authors.forename: Dominique Ngono
authors.initials: DN
authors.lastname: Bikobo
authors.forename: Alex de Théodore
authors.initials: Ade T
authors.lastname: Atchadé
authors.forename: Dieudonné Emmanuel
authors.initials: DE
authors.lastname: Pegnyemb
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001156:Artemia / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002163:Cameroon; D002176:Candida albicans / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D043842:Ochnaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C554979:4'''-O-methylagathisflavone; D000470:Alkaloids; D047188:Chalcones; D003603:Cytotoxins; D005419:Flavonoids; D005960:Glucosides; D026121:Indole Alkaloids; C554980:flavumchalcone; C554981:flavumindole