title: Recent advances in hydrogen research as a therapeutic medical gas.
abstract: Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. Therapeutic hydrogen has been applied by different delivery methods including straightforward inhalation, drinking hydrogen dissolved in water and injection with hydrogen-saturated saline. This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. It is not an overstatement to say that hydrogen's impact on therapeutic and preventive medicine could be enormous in the future.
authors.affiliation: Department of Surgery, Taipei-Veterans General Hospital and National Yang-Ming University School of Medicine, Taiwan.
authors.forename: Chien-Sheng
authors.initials: CS
authors.lastname: Huang
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kawamura
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Atsunori
authors.initials: A
authors.lastname: Nakao
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D035843:Biomedical Research / Q000639:trends*; D002617:Chemical Industry / Q000379:methods; D018890:Chemoprevention / Q000379:methods; D004195:Disease Models, Animal; D005740:Gases / Q000627:therapeutic use*; D006801:Humans; D006859:Hydrogen / Q000737:chemistry / Q000502:physiology / Q000627:therapeutic use*; D051034:Inhibitor of Apoptosis Proteins / Q000627:therapeutic use; D008954:Models, Biological
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005740:Gases; D051034:Inhibitor of Apoptosis Proteins; D006859:Hydrogen