Mechanisms underlying rapid aldosterone effects in the kidney.
The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.
Thomas
Warren
W
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ie
Harvey
Brian J
BJ
D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D053503:Epithelial Sodium Channels / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D051379:Mice; D011494:Protein Kinases / Q000502:physiology; D051381:Rats; D017978:Receptors, Growth Factor / Q000502:physiology; D018161:Receptors, Mineralocorticoid / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D053503:Epithelial Sodium Channels; D017978:Receptors, Growth Factor; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; D011494:Protein Kinases; D000254:Sodium-Potassium-Exchanging ATPase