title: [Paracetamol for perioperative analgesia. Old substance - new insights].
abstract: Since paracetamol was first synthesized in 1878 it has become one of the most popular and widely used drugs for the first-line treatment of fever and pain. The reasons for this popularity are a wide variety of formulations, an assumed positive safety record and the wide availability as an over-the-counter drug. However, recently several studies questioned the positive risk-benefit ratio of paracetamol for postoperative pain by observing several possible adverse effects and limitations. The aim of the present review is to give an update of the recent literature on the efficacy of paracetamol for postoperative pain and on the value of the clinical relevance of different adverse effects of paracetamol. Finally, based on the current findings the authors try to assess the role of paracetamol for the treatment of postoperative pain.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48129 Münster. pogatzki@anit.uni-muenster.de
authors.forename: P K
authors.initials: PK
authors.lastname: Zahn
authors.forename: R
authors.initials: R
authors.lastname: Sabatowski
authors.forename: S A
authors.initials: SA
authors.lastname: Schug
authors.forename: U M
authors.initials: UM
authors.lastname: Stamer
authors.forename: E M
authors.initials: EM
authors.lastname: Pogatzki-Zahn
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000473:pathology; D002626:Chemistry, Pharmaceutical; D002648:Child; D004338:Drug Combinations; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D019990:Perioperative Care; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D004338:Drug Combinations; D000082:Acetaminophen
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