title: Endometrial cancer--prospective potential to make diagnostic process more specific.
abstract: OBJECTIVE
  The incidence of carcinoma of endometrium in younger patients has increased tendency. Experimental data support that mutation of tumor suppressor gene TP53 plays an important role in endometrial carcinogenesis
  
  
  METHODS
  Exons 2-11 of the gene TP53 into tissues of endometrial carcinoma and precancerous lesions were analyzed by DNA sequencing and restriction analysis.
  
  
  RESULTS
  A polymorphism CCC/CGC at codon 72 was identified in exon 4 of TP53 gene of all precancerous lesions and carcinomas of endometrium.
  
  
  CONCLUSIONS
  Our results also suggest presence of endometrial glandular dysplasia or serous histological type of endometrial carcinoma into examined samples. Given the course and prognosis of serous endometrial carcinoma, it is necessary and useful to identify this type of cancer in the mixed types of endometrial carcinomas. DNA analysis has potential to make diagnostic process more specific and affect to adjuvant therapy and survival of patients.
authors.affiliation: Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.
authors.forename: Vanda
authors.initials: V
authors.lastname: Repiska
authors.forename: Edward
authors.initials: E
authors.lastname: Radzo
authors.forename: Czaba
authors.initials: C
authors.lastname: Biro
authors.forename: Katarina
authors.initials: K
authors.lastname: Bevizova
authors.forename: Daniel
authors.initials: D
authors.lastname: Bohmer
authors.forename: Stefan
authors.initials: S
authors.lastname: Galbavy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53