[Pathogenesis and new strategy in treatment of neuronal conductivity impairments in compression-ischemic neuropathies: a clinical and experimental study].
Compression-ischemic neuropathies remain one of the most actual problems of contemporary neurology due to the prevalence and commonly poor outcome. In the present work, we studied pathogenetic mechanisms of the formation and restoration of neural conductivity in the compression-ischemic model in rabbits and analyzed some features of therapeutic efficacy of the anticholinesterase drug neuromidin in clinical treatment of compression-ischemic neuropathies. We observed a generalized reaction of the nervous system to the acute limb compression in experimental animals. The ability of neuromidin to improve the central conductivity has been clearly shown. The results obtained allow recommending neuromidin in the treatment of patients with compression-ischemic neuropathies owing to its central and peripheral effects.
Zhivolupov
S A
SA
Shapkova
E Iu
EIu
Samartsev
I N
IN
Fedorov
K V
KV
D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007511:Ischemia / Q000150:complications* / Q000473:pathology; D008297:Male; D009408:Nerve Compression Syndromes / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D009431:Neural Conduction / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits
D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; C049860:amiridine