title: PROlocalizer: integrated web service for protein subcellular localization prediction.
abstract: Subcellular localization is an important protein property, which is related to function, interactions and other features. As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed. We developed the PROlocalizer service that integrates 11 individual methods to predict altogether 12 localizations for animal proteins. The method allows the submission of a number of proteins and mutations and generates a detailed informative document of the prediction and obtained results. PROlocalizer is available at http://bioinf.uta.fi/PROlocalizer/ .
authors.affiliation: Department of Signal Processing, Tampere University of Technology, Tampere, Finland.
authors.forename: Kirsti
authors.initials: K
authors.lastname: Laurila
authors.forename: Mauno
authors.initials: M
authors.lastname: Vihinen
mesh_terms: D000818:Animals; D006801:Humans; D020407:Internet; D042541:Intracellular Space / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D021381:Protein Transport; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012984:Software
chemical_list: D011506:Proteins
references.citation: Proteins. 2006 Aug 15;64(3):643-51
references.pmid: 16752418
references.citation: Proteomics. 2004 Jun;4(6):1571-80
references.pmid: 15174127
references.citation: J Mol Biol. 2000 Jul 21;300(4):1005-16
references.pmid: 10891285
references.citation: Nat Protoc. 2007;2(4):953-71
references.pmid: 17446895
references.citation: Biochem Biophys Res Commun. 2007 Apr 20;355(4):1006-11
references.pmid: 17346678
references.citation: J Mol Biol. 2004 Jul 16;340(4):783-95
references.pmid: 15223320
references.citation: BMC Bioinformatics. 2005 Oct 14;6:256
references.pmid: 16225690
references.citation: J Mol Biol. 2004 May 14;338(5):1027-36
references.pmid: 15111065
references.citation: BMC Genomics. 2009 Mar 23;10:122
references.pmid: 19309509
references.citation: J Mol Biol. 2003 May 2;328(3):567-79
references.pmid: 12706717
references.citation: Bioinformatics. 2005 Nov 1;21(21):3963-9
references.pmid: 16144808
references.citation: Nucleic Acids Res. 2007 Jul;35(Web Server issue):W585-7
references.pmid: 17517783
references.citation: Genomics Proteomics Bioinformatics. 2004 Nov;2(4):209-15
references.pmid: 15901249
references.citation: Bioinformatics. 2002 Aug;18(8):1109-15
references.pmid: 12176834
references.citation: J Mol Biol. 1999 Sep 24;292(3):741-58
references.pmid: 10497036
references.citation: J Mol Biol. 2003 Jul 4;330(2):443-56
references.pmid: 12823981
references.citation: Protein Eng. 1998 Dec;11(12):1155-61
references.pmid: 9930665
references.citation: Biomol Eng. 2007 Jun;24(2):155-68
references.pmid: 17376740
references.citation: Trends Biochem Sci. 2000 Jul;25(7):340-1
references.pmid: 10871885
references.citation: Bioinformatics. 2004 Mar 1;20(4):547-56
references.pmid: 14990451
references.citation: Proc Int Conf Intell Syst Mol Biol. 1998;6:175-82
references.pmid: 9783223
references.citation: J Mol Biol. 2003 May 2;328(3):581-92
references.pmid: 12706718
references.citation: Trends Biochem Sci. 1999 Jan;24(1):34-6
references.pmid: 10087920
references.citation: PLoS One. 2010 Apr 01;5(4):e9931
references.pmid: 20368981
references.citation: BMC Bioinformatics. 2006 Dec 18;7 Suppl 5:S3
references.pmid: 17254308
references.citation: J Biol Chem. 2005 Apr 15;280(15):14427-32
references.pmid: 15647269
references.citation: Curr Opin Struct Biol. 1999 Dec;9(6):754-9
references.pmid: 10607673
references.citation: Hum Mutat. 2009 May;30(5):703-14
references.pmid: 19267389
references.citation: Brief Bioinform. 2002 Dec;3(4):361-76
references.pmid: 12511065
references.citation: J Mol Biol. 2005 Apr 22;348(1):85-100
references.pmid: 15808855
references.citation: Protein Eng. 1999 May;12(5):387-94
references.pmid: 10360979
references.citation: Curr Protein Pept Sci. 2002 Dec;3(6):615-22
references.pmid: 12470215
references.citation: Trends Cell Biol. 1998 Oct;8(10):410-5
references.pmid: 9789330
references.citation: J Mol Biol. 2001 Jan 19;305(3):567-80
references.pmid: 11152613
references.citation: EMBO Rep. 2000 Nov;1(5):411-5
references.pmid: 11258480
references.citation: Curr Opin Chem Biol. 2004 Feb;8(1):49-53
references.pmid: 15036156
references.citation: Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W362-5
references.pmid: 16845026