The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.
BACKGROUND
Exposure of the immature mammalian brain to stress factors, including stress levels of glucocorticoids, either prenatally or postnatally, is regarded as a major regulatory factor in short- and long-term brain function and, in human, as a major aetiological factor in neuropsychiatric disorders. Experimental human studies are not feasible and animal studies are required to demonstrate causality and elucidate mechanisms. A number of studies have been conducted and reviewed in rodents but there are relatively few studies in primates.


OBJECTIVE
Here we present an overview of our published studies and some original data on the effects of: (1) prenatal stress on hypothalamic-pituitary-adrenal (HPA) re/activity and hippocampus neuroanatomy in juvenile-adolescent rhesus macaques; (2) prenatal dexamethasone (DEX) on HPA activity, behaviour and prefrontal cortex neuroanatomy in infant-adolescent common marmosets; (3) postnatal daily parental separation stress on HPA re/activity, behaviour, sleep and hippocampus and prefrontal cortex neuroanatomy in infant-adolescent common marmoset.


RESULTS
Prenatal stress increased basal cortisol levels and reduced neurogenesis in macaque. Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset. Postnatal social stress increased basal cortisol levels, reduced social play, increased awakening and reduced hippocampal glucocorticoid and mineralocorticoid receptor expression in marmoset.


CONCLUSIONS
Perinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset. The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.
Pryce
Christopher R
CR
Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zürich, Schwerzenbach, Switzerland.
Aubert
Yves
Y
Maier
Claudia
C
Pearce
Peter C
PC
Fuchs
Eberhard
E
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002144:Callithrix; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008253:Macaca mulatta; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D013315:Stress, Psychological / Q000150:complications*
D005938:Glucocorticoids; D003907:Dexamethasone
Front Biosci. 2006 Sep 01;11:2746-58
16720347
Brain Pathol. 2006 Jul;16(3):209-17
16911478
Dev Psychobiol. 2001 May;38(4):239-51
11319730
Eur Neuropsychopharmacol. 2010 Jan;20(1):1-17
19748235
Nature. 2001 Mar 15;410(6826):372-6
11268214
Endocrinology. 2008 Dec;149(12):6343-55
18755792
Psychoneuroendocrinology. 2007 May;32(4):331-49
17363175
J Child Psychol Psychiatry. 2007 Mar-Apr;48(3-4):245-61
17355398
Dev Psychobiol. 1993 Dec;26(8):433-46
8293890
Sleep Med Rev. 2001 Jun;5(3):237-246
12530989
Ann N Y Acad Sci. 2004 Dec;1032:245-9
15677420
Biol Psychiatry. 2004 Feb 15;55(4):367-75
14960289
Am J Psychiatry. 2000 Jan;157(1):115-8
10618023
Biol Psychiatry. 2010 Jun 1;67(11):1106-9
20132928
J Evol Biol. 2008 Nov;21(6):1763-78
18808441
Child Dev. 1999 Mar-Apr;70(2):263-74
10218255
Neurosci Biobehav Rev. 1997 Jan;21(1):1-10
8994205
Psychiatry Res. 1984 May;12(1):27-33
6589657
Int J Mol Med. 1998 Nov;2(5):607-14
9858661
Endocr Rev. 1998 Jun;19(3):269-301
9626555
Brain Pathol. 2008 Oct;18(4):497-503
18422980
J Intern Med. 2007 May;261(5):453-60
17444884
FASEB J. 2002 Jul;16(9):1017-26
12087063
J Neuropathol Exp Neurol. 1999 Sep;58(9):932-45
10499436
Arch Gen Psychiatry. 1978 Apr;35(4):429-31
727894
Int J Neuropsychopharmacol. 2009 Jul;12(6):761-72
19102816
J Clin Endocrinol Metab. 2002 Feb;87(2):691-9
11836307
Biol Psychiatry. 2004 Jul 15;56(2):72-9
15231438
Neuroendocrinology. 1992 Feb;55(2):204-13
1320217
Neuropsychopharmacology. 2009 May;34(6):1381-94
18615010
Dev Psychopathol. 1999 Summer;11(3):457-66
10532619
Am J Phys Anthropol. 2007;Suppl 45:133-61
18046747
Arch Gen Psychiatry. 1992 Aug;49(8):651-68; discussion 669-70
1386215
Ann N Y Acad Sci. 1994 Nov 30;746:275-88; discussion 289-93
7825883
Dev Psychobiol. 1993 Jul;26(5):293-304
8339867
Eur J Endocrinol. 2004 Nov;151 Suppl 3:U49-62
15554887
Psychoneuroendocrinology. 2004 Feb;29(2):141-61
14604597
Hippocampus. 2002;12(5):578-84
12440573
Arch Gen Psychiatry. 2000 Aug;57(8):769-75
10920465
Brain Behav Immun. 2005 Jul;19(4):296-308
15944068
Lab Anim. 1979 Apr;13(2):131-3
113619
Behav Brain Funct. 2010 Mar 22;6:18
20307270
Dev Psychobiol. 2002 Sep;41(2):178-85
12209659
Biol Psychiatry. 1996 Mar 15;39(6):400-10
8679785
Br J Psychiatry. 1998 Apr;172:324-6
9715334
Am J Obstet Gynecol. 2003 Feb;188(2):413-8
12592249
Brain Res Dev Brain Res. 1990 May 1;53(2):157-67
2357788
Nat Rev Neurosci. 2009 Jun;10(6):434-45
19401723
Prog Brain Res. 2001;133:131-42
11589126
J Neurobiol. 1999 Sep 5;40(3):302-15
10440731
Am J Phys Anthropol. 2009;140 Suppl 49:137-54
19890864
Int J Dev Neurosci. 1998 Jun-Jul;16(3-4):199-207
9785116
Biol Psychiatry. 2003 Nov 15;54(10):1025-34
14625144
J Pediatr. 2003 Oct;143(4 Suppl):S35-45
14597912
Steroids. 1997 Jan;62(1):89-94
9029721
Sleep Med Rev. 2002 Apr;6(2):125-38
12531148
Psychiatry Res. 1991 Aug;38(2):201-14
1754633
Horm Metab Res. 2007 Jun;39(6):413-9
17578757
Am J Psychiatry. 2002 Jul;159(7):1133-45
12091191
Endocr Rev. 2009 Dec;30(7):753-89
19837868
Physiol Behav. 1998 Feb 15;63(4):591-9
9523903
Cochrane Database Syst Rev. 2000;(2):CD000065
10796110
Trends Neurosci. 2002 Oct;25(10):518-24
12220880
Nat Neurosci. 2004 Aug;7(8):847-54
15220929
Biol Psychiatry. 2002 Dec 1;52(11):1037-46
12460687
Horm Behav. 2009 Oct;56(4):364-75
19616002
Brain Res Mol Brain Res. 1993 May;18(3):195-200
8497182
Neuropsychopharmacology. 2004 Apr;29(4):641-8
15034558
Prog Brain Res. 2008;167:17-34
18037004
Annu Rev Psychol. 2007;58:145-73
16903808
J Psychiatr Res. 1994 Jul-Aug;28(4):341-56
7877114
Neurosci Biobehav Rev. 2005;29(4-5):649-74
15925698
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):57-71
12732223
J Neuroendocrinol. 1999 Jul;11(7):513-20
10444308
J Abnorm Psychol. 1976 Aug;85(4):341-9
821983
Endocrinology. 2007 Apr;148(4):1813-22
17218413
Nat Neurosci. 2002 Nov;5(11):1242-7
12379862
Am J Psychiatry. 2000 Feb;157(2):190-5
10671386
Br J Psychiatry. 1996 Nov;169(5):637-40
8932895
Brain Res Dev Brain Res. 1993 Oct 15;75(2):185-92
8261610
Pediatrics. 1992 Sep;90(3 Pt 2):491-7
1513614
Behav Brain Funct. 2007 Jul 10;3:33
17623072
Biol Psychiatry. 1996 Sep 1;40(5):317-37
8874833
Early Hum Dev. 1991 Jun;25(3):197-208
1935741
J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):34-41
16723223
J Med Primatol. 2009 Jun;38(3):213-8
19374665
Psychol Med. 2010 Feb;40(2):335-45
19476689
Biol Psychiatry. 1995 Jun 15;37(12):859-65
7548460
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12796-801
11675510
Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10
11422885
Biol Psychiatry. 1995 Sep 15;38(6):391-403
8547459
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7
11005874
Brain Res Brain Res Rev. 2000 Mar;31(2-3):130-7
10719141