title: Oxidative stress in obstructive nephropathy.
abstract: Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.
authors.affiliation: Department of Pathology, University Medical Center, Utrecht, The Netherlands.
authors.forename: Amélie
authors.initials: A
authors.lastname: Dendooven
authors.forename: David A
authors.initials: DA
authors.lastname: Ishola
authors.forename: Tri Q
authors.initials: TQ
authors.lastname: Nguyen
authors.forename: Dionne M
authors.initials: DM
authors.lastname: Van der Giezen
authors.forename: Robbert Jan
authors.initials: RJ
authors.lastname: Kok
authors.forename: Roel
authors.initials: R
authors.lastname: Goldschmeding
authors.forename: Jaap A
authors.initials: JA
authors.lastname: Joles
mesh_terms: D000098:Acetophenones / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005355:Fibrosis; D007668:Kidney / Q000473:pathology; D051379:Mice; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D014517:Ureteral Obstruction / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D000098:Acetophenones; D004791:Enzyme Inhibitors; C056165:acetovanillone; D019255:NADPH Oxidases
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