[Combined cycloferon treatment of tuberculosis in patients infected with HIV].
Outcome of treatment of 102 patients co-infected with HIV and tuberculosis hospitalized at Second Municipal Tuberculosis Hospital (St. Petersburg) is analyzed. The median period of follow up was 8 weeks. In order to select the optimum treatment scheme, all patients were divided into three groups (I-III). Group I (51 patients) received, in addition to antituberculosis medications, cycloferon 600 mg tablets on alternate days. Group II (16 patients) received alpha and gamma interferons (Interal injection, 3 MU and Ingaron injection, 500,000 on alternate days) in combination with antituberculosis medications. Control group III (35 patients) received antituberculosis treatment plus placebo. Assessment of the outcome of TB treatment upon 8 weeks of follow up showed a remarkable improvement of clinical and immunological conditions in the patients who received interferons and cycloferon.
Ivanov
A K
AK
Sologub
T V
TV
Panteleev
A M
AM
Sukhanov
D S
DS
Romantsov
M G
MG
Kovalenko
A L
AL
D000166:Acridines / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007369:Interferon Inducers / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use; D007371:Interferon-gamma / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D055815:Young Adult
D000166:Acridines; D007369:Interferon Inducers; D016898:Interferon-alpha; D007371:Interferon-gamma; C026430:10-carboxymethyl-9-acridanone