Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms.
This review focuses on the short and bewildered history of Brazilian scientist Carlos Chagas's discovery and subsequent developments, the anatomopathological features of chronic Chagas cardiomyopathy (CCC), an overview on the controversies surrounding theories concerning its pathogenesis, and studies that support the microvascular hypothesis to further explain the pathological features and clinical course of CCC. It is our belief that knowledge of this particular and remarkable cardiomyopathy will shed light not only on the microvascular involvement of its pathogenesis, but also on the pathogenetic processes of other cardiomyopathies, which will hopefully provide a better understanding of the various changes that may lead to an end-stage heart disease with similar features. This review is written to celebrate the 100th anniversary of the discovery of Chagas disease.
Rossi
Marcos A
MA
Department of Pathology, Laboratory of Cellular and Molecular Cardiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. marossi@fmrp.usp.br
Tanowitz
Herbert B
HB
Malvestio
Lygia M
LM
Celes
Mara R
MR
Campos
Erica C
EC
Blefari
Valdecir
V
Prado
Cibele M
CM
D002598:Chagas Cardiomyopathy / Q000266:history* / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D055806:Microvessels / Q000473:pathology*
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