TGF-beta biology in mammary development and breast cancer.
Transforming growth factor-β1 (TGF-β) was first implicated in mammary epithelial development by Daniel and Silberstein in 1987 and in breast cancer cells and hormone resistance by Lippman and colleagues in 1988. TGF-β is critically important for mammary morphogenesis and secretory function through specific regulation of epithelial proliferation, apoptosis, and extracellular matrix. Differential TGF-β effects on distinct cell types are compounded by regulation at multiple levels and the influence of context on cellular responses. Studies using controlled expression and conditional-deletion mouse models underscore the complexity of TGF-β biology across the cycle of mammary development and differentiation. Early loss of TGF-β growth regulation in breast cancer evolves into fundamental deregulation that mediates cell interactions and phenotypes driving invasive disease. Two outstanding issues are to understand the mechanisms of biological control in situ and the circumstances by which TGF-β regulation is subverted in neoplastic progression.
Moses
Harold
H
Department of Cancer Biology and Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA.
Barcellos-Hoff
Mary Helen
MH
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000254:growth & development*; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D053773:Transforming Growth Factor beta1
Cancer Sci. 2008 Nov;99(11):2107-12
18808420
FASEB J. 1997 Oct;11(12):991-1002
9337152
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5076-81
9560231
J Virol. 1996 Dec;70(12):8624-9
8970987
Proc Natl Acad Sci U S A. 1995 May 9;92(10):4254-8
7753792
Cell. 2008 Apr 4;133(1):66-77
18394990
Breast Cancer Res. 2009;11(5):R72
19788752
Development. 1996 Dec;122(12):4013-22
9012521
Nature. 2003 Oct 9;425(6958):577-84
14534577
Radiat Res. 2006 Dec;166(6):839-48
17149983
J Cell Biol. 1993 Jan;120(1):245-51
8416990
Mol Carcinog. 2009 Mar;48(3):181-186
18655107
Cancer Res. 1987 Nov 15;47(22):6052-7
3664507
Int J Radiat Biol. 2007 Nov-Dec;83(11-12):803-11
18058368
Cell. 1997 Jun 27;89(7):1165-73
9215638
Oncogene. 2005 Jul 28;24(32):5053-68
15856015
Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):159-68
10708963
Dev Biol. 1989 Sep;135(1):20-30
2767334
Cancer Res. 2007 Dec 15;67(24):11517-27
18089780
Annu Rev Cell Dev Biol. 2005;21:659-93
16212511
Genes Dev. 2005 Dec 1;19(23):2783-810
16322555
J Cell Biol. 1988 May;106(5):1659-65
2967299
EMBO J. 2007 Sep 5;26(17):3957-67
17673906
J Cell Biol. 1993 Jan;120(1):253-60
8416992
Mol Reprod Dev. 1992 Jun;32(2):145-51
1637552
J Cell Physiol. 1998 Feb;174(2):186-93
9428805
Mol Cell Biol. 1990 Apr;10(4):1492-7
2108318
J Cell Biol. 1990 Jun;110(6):2209-19
2351697
Cancer Res. 1997 Nov 15;57(22):4987-91
9371488
Dev Biol. 1992 Aug;152(2):354-62
1644225
Cancer Res. 1991 Sep 1;51(17):4685-92
1873813
Nature. 1997 Oct 9;389(6651):631-5
9335507
EMBO J. 1993 May;12(5):1835-45
8491177
Am J Pathol. 1995 Nov;147(5):1228-37
7485387
Science. 1999 Oct 22;286(5440):771-4
10531062
J Cell Physiol. 2009 Apr;219(1):57-68
19086032
Cancer Cell. 2008 Jan;13(1):23-35
18167337
J Cell Biol. 1993 Aug;122(4):923-32
8349738
Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):41-58
16310402
Mol Cell Biol. 1989 Mar;9(3):1255-62
2725496
Development. 1992 May;115(1):49-58
1638991
Cancer Sci. 2007 Oct;98(10):1512-20
17645776
Cell. 2003 Jun 13;113(6):685-700
12809600
JAMA. 2009 Oct 21;302(15):1685-92
19843904
Cancer Res. 2005 Mar 15;65(6):2296-302
15781643
Mol Biol Cell. 1999 Apr;10(4):1221-34
10198068
Cell. 1987 Feb 13;48(3):417-28
2879636
J Biol Chem. 1992 Jul 5;267(19):13702-7
1618868
Cancer Cell. 2007 Mar;11(3):259-73
17349583
Cancer Res. 1997 Dec 15;57(24):5564-70
9407968
Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4315-30
16857807
J Biol Chem. 1995 Mar 3;270(9):4689-96
7876240
Science. 2006 Oct 13;314(5797):298-300
17038622
Cancer Res. 2002 May 15;62(10):2778-90
12019154
Am J Pathol. 2005 Aug;167(2):409-17
16049327
Genes Dev. 2000 Jan 15;14(2):163-76
10652271
J Biol Chem. 1989 Aug 15;264(23):13660-4
2474534
Science. 2004 Feb 6;303(5659):848-51
14764882
Genes Dev. 1995 Sep 15;9(18):2266-78
7557380
Am J Pathol. 2002 Jun;160(6):2081-93
12057913
Cell. 2008 Jul 25;134(2):215-30
18662538
Science. 1987 Jul 17;237(4812):291-3
3474783
Am J Pathol. 2003 Oct;163(4):1539-49
14507660
Exp Cell Res. 1990 Sep;190(1):127-32
2387324
Cancer Res. 2002 Jan 15;62(2):497-505
11809701
Cancer Res. 2008 Mar 15;68(6):1809-19
18339861
Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12747-52
16908841
Mol Endocrinol. 1996 Sep;10(9):1077-83
8885242
Nat Rev Drug Discov. 2004 Dec;3(12):1011-22
15573100
Cancer Res. 1992 Aug 1;52(15):4261-4
1322240
J Cell Biochem. 2007 May 1;101(1):9-33
17340614
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71
2424019
J Clin Invest. 2002 Jun;109(12):1607-15
12070308
Mol Cell. 2008 Sep 26;31(6):918-24
18922473
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3412-5
2014262
N Engl J Med. 1993 Jun 3;328(22):1592-8
8487801
Oncogene. 1999 Dec 2;18(51):7280-6
10602482
J Biol Chem. 2001 Apr 20;276(16):12477-80
11278251
Cell. 1999 Feb 5;96(3):319-28
10025398
Endocrinology. 1990 Dec;127(6):2963-8
2249636
Breast Cancer Res Treat. 2009 Jun;115(3):453-95
18841463
Genes Dev. 1999 Sep 1;13(17):2196-206
10485843
J Clin Invest. 2009 Jun;119(6):1571-82
19451693
Cell Tissue Res. 1992 Apr;268(1):167-77
1499048
Nature. 1989 Mar 9;338(6211):158-60
2493139
Crit Rev Oncog. 1993;4(5):493-540
8241322
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4966-71
15051869
Genes Dev. 1993 Dec;7(12A):2308-17
8253379
J Cell Physiol. 1993 Apr;155(1):210-21
8385676
Cell Cycle. 2009 Oct 15;8(20):3319-27
19806012
Gastroenterology. 2002 Jul;123(1):352-64
12105863
Oncogene. 2006 Jun 8;25(24):3408-23
16186809
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8430-5
12808151
Oncogene. 2006 Jan 5;25(1):1-7
16278683
Mol Cell Biol. 2008 Nov;28(22):6889-902
18794361
EMBO J. 2009 Jan 21;28(2):88-98
19096363
Cancer Res. 2008 Oct 15;68(20):8304-11
18922902
Endocrinology. 1997 Jun;138(6):2466-73
9165037
Biochem Biophys Res Commun. 1996 Mar 27;220(3):879-85
8607860
Mol Cell. 2000 Dec;6(6):1365-75
11163210
Dev Biol. 1995 Mar;168(1):47-61
7883078
Development. 2000 Jul;127(14):3107-18
10862748
Mol Biol Cell. 1992 Oct;3(10):1057-65
1421565
Cancer Res. 2004 Dec 15;64(24):9002-11
15604265
Oncogene. 2001 Apr 26;20(18):2264-72
11402321
Carcinogenesis. 1993 Oct;14(10):2019-25
8222048