title: The use of the Active Breathing Coordinator throughout radical non-small-cell lung cancer (NSCLC) radiotherapy.
abstract: OBJECTIVE
  To assess feasibility and reproducibility of an Active Breathing Coordinator (ABC) used throughout radical radiotherapy for non-small-cell lung cancer, and compare lung dosimetric parameters between free-breathing and ABC plans.
  
  
  METHODS
  A total of 18 patients, recruited into an approved study, had free-breathing and ABC breath-hold treatment plans generated. Lung volume, the percentage volume of lung treated to a dose of ≥20 Gy (V(20)), and mean lung dose (MLD) were compared. Treatment (64 Gy in 32 fractions, 5 days/week) was delivered in breath-hold. Repeat breath-hold computed tomography scans were used to assess change in gross tumor volume (GTV) size and position. Setup error was also measured and potential GTV-planning target volume (PTV) margins calculated.
  
  
  RESULTS
  Seventeen of 18 patients completed radiotherapy using ABC daily. Intrafraction tumor position was consistent, but interfraction variation had mean (range) values of 5.1 (0-25), 3.6 (0-9.7), and 3.5 (0-16.6) mm in the superoinferior (SI), right-left (RL), and anteroposterior (AP) directions, respectively. Tumor moved partially outside the PTV in 5 patients. Mean reduction in GTV from planning to end of treatment was 25% (p = 0.003). Potentially required PTV margins were 18.1, 11.9, and 11.9 mm in SI, RL, and AP directions. ABC reduced V(20) by 13% (p = 0.0001), V(13) by 12% (p = 0.001), and MLD by 13% (p < 0.001) compared with free-breathing; lung volume increased by 41% (p < 0.001).
  
  
  CONCLUSIONS
  Clinically significant movements of GTV were seen during radiotherapy for non-small-cell lung cancer using ABC. Image guidance is recommended with ABC. The use of ABC can reduce dose volume parameters determining lung toxicity, and might allow for equitoxic radiotherapy dose escalation.
authors.affiliation: Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Downs Road, Sutton, Surrey, UK. juliet.brock@icr.ac.uk
authors.forename: Juliet
authors.initials: J
authors.lastname: Brock
authors.forename: Helen A
authors.initials: HA
authors.lastname: McNair
authors.forename: Niki
authors.initials: N
authors.lastname: Panakis
authors.forename: Richard
authors.initials: R
authors.lastname: Symonds-Tayler
authors.forename: Phil M
authors.initials: PM
authors.lastname: Evans
authors.forename: Michael
authors.initials: M
authors.lastname: Brada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009068:Movement; D009929:Organ Size; D056888:Patient Positioning; D015272:Pulmonary Medicine / Q000295:instrumentation*; D020266:Radiotherapy, Conformal / Q000379:methods; D015203:Reproducibility of Results; D012119:Respiration; D014057:Tomography, X-Ray Computed / Q000379:methods; D047368:Tumor Burden