title: Common acute lymphoblastic leukemia Ph+ following Langerhans cell histiocytosis in a multi-malformed child with INV (9) (p12;q13) (mat): case report.
abstract: The occurrence of Langerhans cell histiocytosis (LCH) and another malignancy in the same patient is infrequent but has been recognized. The genetic changes that could be responsible for LCH and/or concomitant leukemia development are obscure. To the best of our knowledge, this is the first description of constitutional maternally derived inv (9) (p12;q13) in an LCH patient, and also of the development of common ALL Ph after LCH diagnosis and therapy. The potential significance of these findings [inv (9)+LCH+ALL Ph+] and their mutual relationship are unknown. Therefore, cooperative studies of large numbers of patients are needed to identify the common risk factors, if any.
authors.affiliation: Division of Molecular Medicine, Laboratory of Molecular Oncology, Ruder Boskovic Institute, 10000 Zagreb, Croatia. jpavelic@irb.hr
authors.forename: Jasminka
authors.initials: J
authors.lastname: Pavelić
authors.forename: Srdjana
authors.initials: S
authors.lastname: Culić
authors.forename: Vida
authors.initials: V
authors.lastname: Culić
mesh_terms: D002675:Child, Preschool; D007446:Chromosome Inversion / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015897:Comorbidity; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000235:genetics; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics