title: Effects of annual mass treatment with ivermectin for onchocerciasis on the prevalence of intestinal helminths.
abstract: We evaluated the effect of annual ivermectin (IV) distribution for onchocerciasis on the prevalence of soil transmitted helminth (STH) infections in school-aged (SAC) and preschool-aged (PAC) children by comparing children in villages that had received treatment for 13 years to those from socioeconomically similar villages in untreated areas. We enrolled 1,031 SAC and 211 PAC for Kato Katz examinations. Treated areas had a lower prevalence of Ascaris (SAC: 3% versus 12%, P < 0.0001; PAC: 3% versus 10%, P < 0.051) and Trichuris (SAC: 6% versus 10%, P = 0.012; PAC: 1% versus 8%, P = 0.019), but not hookworm (SAC: 38% versus 42%, P = 0.20; PAC: 21% versus 27%, P = 0.30). The prevalence of Ascaris or Trichuris in treated areas was below the WHO threshold for mass antihelminthic treatment (MDA), but not for hookworm. We conclude that benzimidazole MDA in IV treatment areas is indicated to effectively control hookworm.
authors.affiliation: Emory University School of Medicine, Division of Pediatric Infectious Diseases, Atlanta, Georgia, USA. gutmanjr@gmail.com
authors.forename: Julie
authors.initials: J
authors.lastname: Gutman
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Emukah
authors.forename: Njideka
authors.initials: N
authors.lastname: Okpala
authors.forename: Chinyere
authors.initials: C
authors.lastname: Okoro
authors.forename: Andrew
authors.initials: A
authors.lastname: Obasi
authors.forename: Emmanuel S
authors.initials: ES
authors.lastname: Miri
authors.forename: Frank O
authors.initials: FO
authors.lastname: Richards
mesh_terms: D000293:Adolescent; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006376:Helminths / Q000302:isolation & purification*; D006801:Humans; D007422:Intestines / Q000469:parasitology*; D007559:Ivermectin / Q000494:pharmacology / Q000627:therapeutic use*; D009855:Onchocerciasis / Q000188:drug therapy*; D015995:Prevalence
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin
references.citation: Am J Trop Med Hyg. 1988 Nov;39(5):480-3
references.pmid: 3195695
references.citation: Trans R Soc Trop Med Hyg. 1996 Nov-Dec;90(6):630-3
references.pmid: 9015498
references.citation: PLoS Negl Trop Dis. 2008 Sep 10;2(9):e293
references.pmid: 18820741
references.citation: Annu Rev Nutr. 2002;22:35-59
references.pmid: 12055337
references.citation: Am J Trop Med Hyg. 1998 Apr;58(4):470-5
references.pmid: 9574794
references.citation: Am J Trop Med Hyg. 1994 Jul;51(1):36-9
references.pmid: 8059913
references.citation: Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):232-4
references.pmid: 1909471
references.citation: Southeast Asian J Trop Med Public Health. 2006 Sep;37(5):865-74
references.pmid: 17333727
references.citation: JAMA. 2008 Apr 23;299(16):1937-48
references.pmid: 18430913
references.citation: Am J Trop Med Hyg. 1989 Mar;40(3):304-9
references.pmid: 2929853
references.citation: J Nutr. 2004 Feb;134(2):348-56
references.pmid: 14747671
references.citation: Trans R Soc Trop Med Hyg. 2002 Nov-Dec;96(6):600-4
references.pmid: 12625131
references.citation: BMC Infect Dis. 2009 Feb 19;9:20
references.pmid: 19228385
references.citation: Bull World Health Organ. 2004 Aug;82(8):563-71
references.pmid: 15375445
references.citation: Am J Trop Med Hyg. 1996 Nov;55(5):477-81
references.pmid: 8940976
references.citation: Parasitol Today. 1997 Nov;13(11):438-43
references.pmid: 15275146
references.citation: Am J Trop Med Hyg. 2002 Sep;67(3):266-72
references.pmid: 12408665
references.citation: Trans R Soc Trop Med Hyg. 2009 Mar;103(3):237-41
references.pmid: 18814894
references.citation: PLoS Negl Trop Dis. 2009;3(3):e402
references.pmid: 19333371
references.citation: J Helminthol. 2009 Sep;83(3):261-6
references.pmid: 19356265
references.citation: Parasitology. 2000;121 Suppl:S23-38
references.pmid: 11386688
references.citation: Ann Trop Med Parasitol. 1998 Apr;92 Suppl 1:S79-83
references.pmid: 9861272
references.citation: Curr Opin Infect Dis. 2006 Dec;19(6):588-93
references.pmid: 17075336
references.citation: Bull World Health Organ. 2003;81(1):35-42
references.pmid: 12640474
references.citation: Trans R Soc Trop Med Hyg. 2010 Feb;104(2):129-32
references.pmid: 19926104
references.citation: Am J Trop Med Hyg. 2004 May;70(5):556-61
references.pmid: 15155991
references.citation: BMJ. 2001 Dec 15;323(7326):1389-93
references.pmid: 11744561
references.citation: Am J Trop Med Hyg. 1980 Mar;29(2):217-9
references.pmid: 7369441
references.citation: Ethiop Med J. 1994 Jan;32(1):7-15
references.pmid: 8187782
references.citation: PLoS Negl Trop Dis. 2008 Mar 26;2(3):e126
references.pmid: 18365031
references.citation: Int J Epidemiol. 2001 Dec;30(6):1457-64
references.pmid: 11821364
references.citation: Ann Trop Med Parasitol. 2001 Jun;95(4):389-93
references.pmid: 11454248
references.citation: World Health Organ Tech Rep Ser. 2002;912:i-vi, 1-57, back cover
references.pmid: 12592987
references.citation: Wkly Epidemiol Rec. 2008 Aug 22;83(34):307-12
references.pmid: 18720576