title: Incidence and severity of oral mucositis in patients undergoing haematopoietic SCT--results of a multicentre study.
abstract: Oral mucositis (OM) is a common side effect experienced during haematopoietic SCT (HSCT), and it can have a significant impact on the quality of life of patients. A descriptive nurse-led study was undertaken in 19-member centres of the Italian national transplant group (GITMO) evaluating incidence, severity and duration of OM in patients undergoing HSCT. Data from 1841 patients between 2002 and 2006 was analyzed. Initial medical history and oral cavity assessment was performed. Assessment was repeated on the day of transplant, then daily, using the WHO (World Health Organisation) oral toxicity scale. A total of 71% of the patients evaluated developed mucositis and 21.6% developed severe mucositis. Duration of OM in most cases lasted for 10-14 days and resolved along with marrow reconstitution. Oral mucostitis is a frequent side effect in patients undergoing HSCT. The onset of severe mucositis seems to be related to the conditioning regimen used. This database provides a descriptive overview of the incidence and severity of mucositis and has encouraged participating centres to adopt routine evaluation and measurement of the oral cavity. The assessment tools are still used in some centres, providing a basis for further collaborative research projects.
authors.affiliation: Experimental Paediatrics, Department of Paediatrics, Doctoral School in Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy. liliana.vagliano@unito.it
authors.forename: L
authors.initials: L
authors.lastname: Vagliano
authors.forename: C
authors.initials: C
authors.lastname: Feraut
authors.forename: G
authors.initials: G
authors.lastname: Gobetto
authors.forename: A
authors.initials: A
authors.lastname: Trunfio
authors.forename: A
authors.initials: A
authors.lastname: Errico
authors.forename: V
authors.initials: V
authors.lastname: Campani
authors.forename: G
authors.initials: G
authors.lastname: Costazza
authors.forename: A
authors.initials: A
authors.lastname: Mega
authors.forename: V
authors.initials: V
authors.lastname: Matozzo
authors.forename: M
authors.initials: M
authors.lastname: Berni
authors.forename: F
authors.initials: F
authors.lastname: Alberani
authors.forename: M M
authors.initials: MM
authors.lastname: Banfi
authors.forename: L
authors.initials: L
authors.lastname: Martinelli
authors.forename: S
authors.initials: S
authors.lastname: Munaron
authors.forename: L
authors.initials: L
authors.lastname: Orlando
authors.forename: L
authors.initials: L
authors.lastname: Lubiato
authors.forename: S
authors.initials: S
authors.lastname: Leanza
authors.forename: R
authors.initials: R
authors.lastname: Guerrato
authors.forename: A
authors.initials: A
authors.lastname: Rossetti
authors.forename: M
authors.initials: M
authors.lastname: Messina
authors.forename: L
authors.initials: L
authors.lastname: Barzetti
authors.forename: G
authors.initials: G
authors.lastname: Satta
authors.forename: V
authors.initials: V
authors.lastname: Dimonte
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000451:nursing; D006801:Humans; D015994:Incidence; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013280:Stomatitis / Q000453:epidemiology* / Q000209:etiology; D019172:Transplantation Conditioning / Q000009:adverse effects* / Q000451:nursing