title: Comprehensive geriatric assessment in Korean elderly cancer patients receiving chemotherapy.
abstract: BACKGROUND
  Growing evidence suggests that a comprehensive geriatric assessment (CGA) in older patients with cancer can detect unsuspected health problems, predict survival, and predict tolerance to chemotherapy. However, studies regarding CGA in cancer patients are scarce in Asia.
  
  
  METHODS
  We prospectively enrolled 65 elderly cancer patients who were candidates of systemic chemotherapy between July 2006 and March 2008. Baseline CGA data including demographic information, comorbidity, functional status by means of Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL), cognition, psychological state, nutritional status, and medication were collected and analyzed. Quality of life (QoL) was assessed by the EORTC questionnaire QLQ-C30.
  
  
  RESULTS
  Of the 65 patients, the median age was 71 years (range, 65-80), 49 (75%) were males, and 58 (89%) had Eastern Cooperative Oncology Group performance status (ECOG PS) 0 or 1. All patients had solid tumor, 74% received palliative chemotherapy, and 18% received adjuvant chemotherapy. Twenty-five percent of patients had Charlson's comorbidity index score of 2 or more, 23% were ADL dependent, and 14% were IADL dependent. Using Mini-Mental Status Exam (MMSE), it was found that 51% of patients had mild cognitive impairment (MMSE score 17-24), and 5% had cognitive impairment (≤ 16). Forty percent of patients had depression by Short form Geriatric Depression Scale (SGDS), 19% had malnutrition by Mini-Nutritional Assessment (MNA), and 23% had body mass index (BMI) less than 19.4 kg/m(2) (lowest 10%). Global health status/quality of life (QoL) was less than 50% in 39% of patients. Frail patients according to the Balducci classification had significantly poor ECOG PS and worse global health status/QoL.
  
  
  CONCLUSIONS
  CGA was feasible and could detect multiple unsuspected health problems including functional impairment and malnutrition in Korean elderly cancer patients receiving chemotherapy.
authors.affiliation: Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam, 463-707, Korea.
authors.forename: Yu Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Park
authors.forename: Keun-Wook
authors.initials: KW
authors.lastname: Lee
authors.forename: Kwang-Il
authors.initials: KI
authors.lastname: Kim
authors.forename: Soo-Mee
authors.initials: SM
authors.lastname: Bang
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Cheol-Ho
authors.initials: CH
authors.lastname: Kim
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007723:Korea; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life
references.citation: J Psychosom Res. 2004 Sep;57(3):297-305
references.pmid: 15507257
references.citation: Cancer. 2000 Aug 1;89(3):561-73
references.pmid: 10931455
references.citation: J Clin Oncol. 1998 Apr;16(4):1582-7
references.pmid: 9552069
references.citation: Gerontologist. 1969 Autumn;9(3):179-86
references.pmid: 5349366
references.citation: J Clin Oncol. 2007 May 10;25(14):1824-31
references.pmid: 17488980
references.citation: J Natl Cancer Inst. 1993 Mar 3;85(5):365-76
references.pmid: 8433390
references.citation: J Clin Oncol. 2003 Apr 1;21(7):1383-9
references.pmid: 12663731
references.citation: Am J Med. 1980 Oct;69(4):491-7
references.pmid: 7424938
references.citation: Eur J Cancer. 2007 Oct;43(15):2161-9
references.pmid: 17855074
references.citation: Ann Oncol. 2005 Nov;16(11):1795-800
references.pmid: 16093275
references.citation: Crit Rev Oncol Hematol. 2000 Sep;35(3):147-54
references.pmid: 10960797
references.citation: J Natl Cancer Inst. 1993 Oct 6;85(19):1580-4
references.pmid: 8411231
references.citation: J Cancer Res Clin Oncol. 2007 Dec;133(12):945-50
references.pmid: 17534661
references.citation: Crit Rev Oncol Hematol. 2001 Sep;39(3):269-73
references.pmid: 11500267
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Md State Med J. 1965 Feb;14:61-5
references.pmid: 14258950
references.citation: N Engl J Med. 2001 Oct 11;345(15):1091-7
references.pmid: 11596588
references.citation: N Engl J Med. 1999 Dec 30;341(27):2061-7
references.pmid: 10615079
references.citation: J Clin Oncol. 2005 Oct 1;23(28):6865-72
references.pmid: 16192578
references.citation: JAMA. 2005 Mar 2;293(9):1073-81
references.pmid: 15741529
references.citation: Qual Life Res. 2004 May;13(4):863-8
references.pmid: 15129896
references.citation: J Am Geriatr Soc. 1991 Feb;39(2):142-8
references.pmid: 1991946
references.citation: Cancer. 1991 May 1;67(9):2227-34
references.pmid: 2013029
references.citation: Crit Rev Oncol Hematol. 2008 Feb;65(2):156-63
references.pmid: 18082416
references.citation: Cancer. 2003 Feb 15;97(4):1107-14
references.pmid: 12569613
references.citation: J Am Geriatr Soc. 2007 Oct;55(10):1604-8
references.pmid: 17697101
references.citation: J Clin Oncol. 2002 Jan 15;20(2):494-502
references.pmid: 11786579
references.citation: Crit Rev Oncol Hematol. 2008 Jun;66(3):237-47
references.pmid: 18243010
references.citation: J Chronic Dis. 1987;40(5):373-83
references.pmid: 3558716
references.citation: Cancer. 1994 Oct 1;74(7 Suppl):1995-2003
references.pmid: 8087762
references.citation: Oncologist. 2000;5(3):224-37
references.pmid: 10884501
references.citation: Int J Radiat Oncol Biol Phys. 1996 Feb 1;34(3):565-70
references.pmid: 8621279
references.citation: Chest. 2000 May;117(5):1239-46
references.pmid: 10807806
references.citation: Nutrition. 1999 Feb;15(2):116-22
references.pmid: 9990575
references.citation: J Am Geriatr Soc. 2001 Jul;49(7):968-79
references.pmid: 11527490
references.citation: J Clin Oncol. 2005 Dec 20;23(36):9113-9
references.pmid: 16361618
references.citation: JAMA. 1998 Apr 15;279(15):1187-93
references.pmid: 9555758
references.citation: J Am Geriatr Soc. 2002 Jul;50(7):1233-9
references.pmid: 12133018
references.citation: Am J Med. 1992 Dec;93(6):663-9
references.pmid: 1466363
references.citation: J Clin Oncol. 1994 Nov;12(11):2447-52
references.pmid: 7964962
references.citation: Hanguk Nonyonhak. 2009;29(4):1479-1500
references.pmid: 25285028