title: Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease.
abstract: OBJECTIVE
  To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.
  
  
  METHODS
  CAC was measured by electron beam tomography at the baseline and at a follow-up 6.0±0.5 years later. The study population included 443 participants with type 1 diabetes and 526 control subjects who were free of diagnosed coronary artery disease at baseline. The presence of renal disease was defined by the presence of albuminuria and/or low glomerular filtration rate.
  
  
  RESULTS
  In subjects without renal disease, serum UA predicted CAC progression (odds ratio 1.30 [95% CI 1.07-1.58], P=0.007) independent of conventional cardiovascular risk factors including diabetes and the presence of metabolic syndrome.
  
  
  CONCLUSIONS
  Serum UA levels predict the progression of coronary atherosclerosis and may be useful in identifying who is at risk for vascular disease in the absence of significant chronic kidney disease.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA.
authors.forename: Ticiana C
authors.initials: TC
authors.lastname: Rodrigues
authors.forename: David M
authors.initials: DM
authors.lastname: Maahs
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
authors.forename: Diana I
authors.initials: DI
authors.lastname: Jalal
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Kinney
authors.forename: Christopher
authors.initials: C
authors.lastname: Rivard
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
authors.forename: Janet K
authors.initials: JK
authors.lastname: Snell-Bergeon
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007674:Kidney Diseases; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
references.citation: J Am Soc Nephrol. 2005 Dec;16(12):3553-62
references.pmid: 16251237
references.citation: Nephrol Dial Transplant. 2010 Jun;25(6):1865-9
references.pmid: 20064950
references.citation: Diabete Metab. 1993;19(1 Pt 2):159-66
references.pmid: 8314420
references.citation: N Engl J Med. 2008 Oct 23;359(17):1811-21
references.pmid: 18946066
references.citation: Metabolism. 2008 May;57(5):625-9
references.pmid: 18442624
references.citation: Clin J Am Soc Nephrol. 2008 May;3(3):706-13
references.pmid: 18272826
references.citation: Am J Physiol Renal Physiol. 2008 Oct;295(4):F1134-41
references.pmid: 18701632
references.citation: Diabetes. 2009 Jul;58(7):1668-71
references.pmid: 19411615
references.citation: Am J Cardiol. 2007 Jul 1;100(1):115-21
references.pmid: 17599452
references.citation: JAMA. 2001 May 16;285(19):2486-97
references.pmid: 11368702
references.citation: JAMA. 2000 May 10;283(18):2404-10
references.pmid: 10815083
references.citation: Diabetes. 2003 Nov;52(11):2833-9
references.pmid: 14578303
references.citation: Mayo Clin Proc. 2006 Nov;81(11):1427-34
references.pmid: 17120397
references.citation: Diabetes Care. 2009 Sep;32(9):1716-20
references.pmid: 19542211
references.citation: AJR Am J Roentgenol. 2004 May;182(5):1327-32
references.pmid: 15100140