title: Long-term management of hepatitis C-seropositive subjects with AntiOxidant Biofactor (AOB), a fermented food supplement.
abstract: The efficacy of AntiOxidant Biofactor (AOB) for the management of apparently healthy subjects with chronic hepatitis C infection was investigated. A total of 60 subjects (35 males, 25 females) participated in the trial. AOB was given orally in 2 packs (3 g per pack) 3 times per day. 17 subjects had taken AOB for 3 years, 31 subjects up to 2 years, and 41 subjects up to one year. The initial mean (SD) serum alamine aminotransferase (ALT) level was 46.3+/-35.4 IU/L, and significant (p0.05, paired t-test) reductions in the mean serum ALT levels were observed at 6 months (38.6+/-21.5 IU/L), 18 months (31.9+/-18.1 IU/L), 2 years (31.2+/-14.6 IU/L), and 3 years (28.0+/-15.9 IU/L). Those presenting with high serum ALT levels (30 subjects) demonstrated significant levels (p0.05, paired t-test) of reduction in the mean serum ALT levels at 6, 12, 18, 24, and 36 months of treatment. No side effects were observed and the AOB treatment was well tolerated by all subjects.
authors.affiliation: Department of Medical Research-Lower Myanmar, No.5 Ziwaka Road, Yangon 11191, Myanmar.
authors.lastname: Myo-Khin
authors.lastname: Myat-Tin-Htwe-Kyaw
authors.lastname: Yi-Yi-Kyaw
authors.lastname: Ohmar-Lwin
authors.lastname: Myat-Phone-Kyaw
authors.lastname: Khin-May-Oo
authors.forename: Kunio
authors.initials: K
authors.lastname: Shimono
authors.forename: Norio
authors.initials: N
authors.lastname: Koide
authors.forename: Shigeru
authors.initials: S
authors.lastname: Okada
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D002052:Myanmar; D010636:Phenols / Q000009:adverse effects / Q000627:therapeutic use*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010636:Phenols; D010936:Plant Extracts; C501911:antioxidant biofactor AOB; D000410:Alanine Transaminase