title: MRI-based multiscale models for the hemodynamic and structural evaluation of surgically reconstructed aortic arches.
abstract: The surgical reconstruction of the aortic arch is necessary in pediatric patients suffering from different types of congenital heart malformations, in particular, coarctation of the aorta. Among the reconstruction techniques used in surgical practice end-to-end anastomosis (E/E), Gore-tex graft interposition (GGI) and Gore-tex patch graft aortoplasty (GPGA) are compared in this study with a control model, employing a computational fluid-structure-interaction scheme. This study analyzes the impact of introducing synthetic materials on aortic hemodynamics and wall mechanics. Three-dimensional (3D) geometries of a porcine aortic arch were derived from magnetic resonance imaging (MRI) images. Inlet conditions were derived from MRI velocimetry. A multiscale approach was used for the imposition of outlet conditions, wherein a lumped parameter net provided an active afterload. Evidence was found that ring-like repairs increased blood velocity, whereas GPGA limited it. Vortex presence was greater and longer lasting in GGI. The highest power losses corresponded to GPGA. GGI had an intermediate effect, while E/E dissipated only slightly more than the control case. Wall stresses peak in a longitudinal strip on the subject's left side of the vessel, particularly in the frontal area. There was a concentration of stress at the suture lines. All surgical techniques performed equally well in restoring physiological pressures.
authors.affiliation: Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London - UK.
authors.forename: S
authors.initials: S
authors.lastname: Pittaccio
authors.forename: F
authors.initials: F
authors.lastname: Migliavacca
authors.forename: R
authors.initials: R
authors.lastname: Balossino
authors.forename: G
authors.initials: G
authors.lastname: Dubini
authors.forename: E-T
authors.initials: ET
authors.lastname: Frund
authors.forename: V
authors.initials: V
authors.lastname: Hjortdal
authors.forename: M
authors.initials: M
authors.lastname: Smerup
authors.forename: E
authors.initials: E
authors.lastname: Morre-Pedersen
authors.forename: M R
authors.initials: MR
authors.lastname: De Leval