Treatment of subsyndromal depressive symptoms in middle-age and older patients with schizophrenia: effect of age on response.
OBJECTIVE
The authors hypothesized that age would moderate the response of patients with schizophrenia and subsyndromal depression (SSD) treated citalopram with depressive symptoms and other outcomes. Also, older patients would exhibit more side effects with citalopram.


METHODS
Participants of 40 years or older had schizophrenia or schizoaffective disorder with SSD. Patients randomly received flexible dosing of citalopram or placebo augmentation of their antipsychotic medication. Linear regression determined whether age had any moderating effect on depressive symptoms, global psychopathology, negative symptoms, mental functioning, and quality of life. Age-related side effects were examined.


RESULTS
There were no significant drug group by age interaction in depressive or psychotic symptoms, mental Short Form-12, or quality of life scores. Similarly, there were few age-related side effect differences.


CONCLUSIONS
Symptoms in younger and older patients with schizophrenia and SSD treated with citalopram seem to respond similarly. Adverse events do not seem to differ with age.
Kasckow
John
J
VA Pittsburgh Health Care System MIRECC and Behavioral Health Service, Pittsburgh, PA, USA. kasckowjw@upmc.edu
Fellows
Ian
I
Golshan
Shahrokh
S
Solorzano
Ellen
E
Meeks
Thomas
T
Zisook
Sidney
S
D000367:Age Factors; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015283:Citalopram / Q000008:administration & dosage / Q000009:adverse effects; D003863:Depression / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D010919:Placebos; D015283:Citalopram
Med Care. 1996 Mar;34(3):220-33
8628042
Drugs Aging. 2008;25(8):631-47
18665657
Am J Psychiatry. 2000 Feb;157(2):172-8
10671383
J Psychopharmacol. 2001 Jun;15(2):127-35
11448086
Schizophr Bull. 1987;13(2):261-76
3616518
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
14399272
Drugs Aging. 2007;24(10):801-14
17896830
Br J Psychiatry Suppl. 1993 Dec;(22):39-44
8110442
Schizophr Bull. 1984;10(3):388-98
6474101
J Clin Psychiatry. 2009 Apr;70(4):562-71
19192468