title: Dairy products and plasma cholesterol levels.
abstract: Cholesterol synthesized in the body or ingested is an essential lipid component for human survival from our earliest life. Newborns ingest about 3-4 times the amount per body weight through mother's milk compared to the dietary intake of adults. A birth level of 1.7 mmol/L plasma total cholesterol will increase to 4-4.5 mmol/L during the nursing period and continue to increase from adulthood around 40% throughout life. Coronary artery disease and other metabolic disorders are strongly associated with low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol as well as triacylglycerol concentration. Milk fat contains a broad range of fatty acids and some have a negative impact on the cholesterol rich lipoproteins. The saturated fatty acids (SFAs), such as palmitic acid (C16:0), myristic acid (C14:0), and lauric acid (C12:0), increase total plasma cholesterol, especially LDL, and constitute 11.3 g/L of bovine milk, which is 44.8% of total fatty acid in milk fat. Replacement of dairy SFA and trans-fatty acids with polyunsaturated fatty acids decreases plasma cholesterol, especially LDL cholesterol, and is associated with a reduced risk of cardiovascular disease. Available data shows different effects on lipoproteins for different dairy products and there is uncertainty as to the impact a reasonable intake amount of dairy items has on cardiovascular risk. The aim of this review is to elucidate the effect of milk components and dairy products on total cholesterol, LDL, HDL, and the LDL/HDL quotients. Based on eight recent randomized control trials of parallel or cross-over design and recent reviews it can be concluded that replacement of saturated fat mainly (but not exclusively) derived from high-fat dairy products with low-fat dairy products lowers LDL/HDL cholesterol and total/HDL cholesterol ratios. Whey, dairy fractions enriched in polar lipids, and techniques such as fermentation, or fortification of cows feeding can be used to produce dairy products with more beneficial effects on plasma lipid profile.
authors.affiliation: Laboratory of Gastroenterology and Nutrition, Department of Clinical Sciences, Medicine, BioMedical Centre B11, Lund University, Lund, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Ohlsson
references.citation: Eur J Nutr. 2009 Jun;48(4):191-203
references.pmid: 19259609
references.citation: J Med Invest. 2007 Aug;54(3-4):385-8
references.pmid: 17878693
references.citation: Am J Clin Nutr. 2004 Apr;79(4):564-9
references.pmid: 15051598
references.citation: Nutr Rev. 2009 May;67(5):273-83
references.pmid: 19386031
references.citation: Folia Microbiol (Praha). 2008;53(5):378-94
references.pmid: 19085072
references.citation: Am J Clin Nutr. 2003 May;77(5):1146-55
references.pmid: 12716665
references.citation: Nutrition. 2009 Mar;25(3):340-9
references.pmid: 19036562
references.citation: J Nutr. 2005 Jul;135(7):1678-82
references.pmid: 15987849
references.citation: Biochem Biophys Res Commun. 2001 Feb 16;281(1):11-7
references.pmid: 11178953
references.citation: J Atheroscler Thromb. 2005;12(2):73-6
references.pmid: 15942116
references.citation: Am J Clin Nutr. 2007 Mar;85(3):678-87
references.pmid: 17344487
references.citation: Eur J Cardiovasc Prev Rehabil. 2007 Oct;14(5):701-6
references.pmid: 17925631
references.citation: Ann Nutr Metab. 2009;54 Suppl 1:33-8
references.pmid: 19641348
references.citation: Am J Clin Nutr. 2009 Oct;90(4):960-8
references.pmid: 19710195
references.citation: Am J Clin Nutr. 2010 Mar;91(3):535-46
references.pmid: 20071648
references.citation: J Perinatol. 2008 May;28(5):335-40
references.pmid: 18337737
references.citation: FASEB J. 1992 May;6(8):2600-7
references.pmid: 1592210
references.citation: Eur J Clin Nutr. 2002 Nov;56(11):1094-101
references.pmid: 12428175
references.citation: J Lipid Res. 2006 Jan;47(1):154-71
references.pmid: 16251722
references.citation: Am J Clin Nutr. 2010 Jan;91(1):46-63
references.pmid: 19939984
references.citation: Metabolism. 2003 Jun;52(6):771-7
references.pmid: 12800105
references.citation: J Nutr. 2004 Oct;134(10):2611-6
references.pmid: 15465755
references.citation: Am J Clin Nutr. 2009 May;89(5):1425-32
references.pmid: 19211817
references.citation: J Nutr Biochem. 2000 May;11(5):244-9
references.pmid: 10876096
references.citation: Int J Epidemiol. 2008 Dec;37(6):1204-8
references.pmid: 18725363
references.citation: Eur J Clin Nutr. 2009 May;63 Suppl 2:S5-21
references.pmid: 19424218
references.citation: Br J Nutr. 2010 Sep;104(5):716-23
references.pmid: 20377924
references.citation: J Am Coll Nutr. 2008 Dec;27(6):735S-40S
references.pmid: 19155433
references.citation: Br J Nutr. 2004 Nov;92(5):791-7
references.pmid: 15533268
references.citation: Am J Clin Nutr. 2003 Mar;77(3):605-11
references.pmid: 12600850
references.citation: J Indian Med Assoc. 1980 Oct 16;75(8):153-6
references.pmid: 7264326
references.citation: PLoS One. 2010 Mar 02;5(3):e9434
references.pmid: 20209147
references.citation: Br Med J. 1979 Nov 10;2(6199):1173-8
references.pmid: 519351
references.citation: Am J Clin Nutr. 1994 Dec;60(6 Suppl):986S-990S
references.pmid: 7977157
references.citation: J Nutr. 2005 Sep;135(9):2075-8
references.pmid: 16140878
references.citation: Am J Clin Nutr. 1996 Feb;63(2):249-53
references.pmid: 8561067
references.citation: J Am Coll Nutr. 2005 Dec;24(6 Suppl):537S-46S
references.pmid: 16373953
references.citation: Am J Clin Nutr. 2008 Mar;87(3):558-66
references.pmid: 18326592
references.citation: J Dairy Res. 2009 Nov;76(4):469-74
references.pmid: 19825213
references.citation: Obes Rev. 2009 Jul;10(4):475-86
references.pmid: 19493303
references.citation: Ann Nutr Metab. 2005 Jan-Feb;49(1):42-8
references.pmid: 15761214
references.citation: Am J Med. 2002 Apr 1;112(5):343-7
references.pmid: 11904107
references.citation: J Dairy Sci. 2009 Oct;92(10):4745-55
references.pmid: 19762790
references.citation: J Pediatr Gastroenterol Nutr. 1998 Nov;27(5):560-7
references.pmid: 9822324
references.citation: Am J Clin Nutr. 2000 Mar;71(3):674-81
references.pmid: 10702159
references.citation: J Nutr. 2004 Jul;134(7):1729-35
references.pmid: 15226461
references.citation: Am J Clin Nutr. 1999 Jun;69(6):1135-43
references.pmid: 10357731
references.citation: Am J Clin Nutr. 2008 Mar;87(3):593-9
references.pmid: 18326596
references.citation: Atherosclerosis. 2003 Jan;166(1):73-84
references.pmid: 12482553
references.citation: Int J Food Sci Nutr. 2008 Mar;59(2):155-65
references.pmid: 17886080
references.citation: Br J Nutr. 2009 Nov;102(9):1267-75
references.pmid: 19682399
references.citation: J Am Coll Nutr. 2004 Apr;23(2):169-76
references.pmid: 15047684
references.citation: Asia Pac J Clin Nutr. 2009;18(3):351-8
references.pmid: 19786383
references.citation: Eur J Clin Nutr. 2005 Sep;59(9):1059-63
references.pmid: 16015270
references.citation: Am J Clin Nutr. 2001 Feb;73(2):246-52
references.pmid: 11157320
references.citation: Lipids Health Dis. 2009 Oct 16;8:44
references.pmid: 19835602
references.citation: J Epidemiol Community Health. 2002 Jun;56(6):471-2
references.pmid: 12011208
references.citation: Obesity (Silver Spring). 2007 Nov;15(11):2605-13
references.pmid: 18070751
references.citation: PLoS Med. 2010 Mar 23;7(3):e1000252
references.pmid: 20351774
references.citation: Atherosclerosis. 2008 Mar;197(1):12-24
references.pmid: 18160071
references.citation: Am J Clin Nutr. 1984 Nov;40(5):1103-19
references.pmid: 6496390
references.citation: Nutr Metab Cardiovasc Dis. 2011 Jan;21(1):39-45
references.pmid: 19819118
references.citation: J Nutr. 2002 Dec;132(12):3642-9
references.pmid: 12468601
references.citation: Prog Lipid Res. 1996 Mar;35(1):53-92
references.pmid: 9039426
references.citation: J Dairy Sci. 2007 Feb;90(2):706-15
references.pmid: 17235147
references.citation: Int J Vitam Nutr Res. 1979;49(2):229-30
references.pmid: 582448
references.citation: J Epidemiol Community Health. 2007 Aug;61(8):695-8
references.pmid: 17630368
references.citation: J Lipid Res. 1997 Sep;38(9):1746-54
references.pmid: 9323584
references.citation: Dig Dis Sci. 2010 Dec;55(12):3377-83
references.pmid: 20393874
references.citation: Pharmacol Res. 2010 Mar;61(3):208-12
references.pmid: 19931617
references.citation: Br J Nutr. 2003 Feb;89(2):239-48
references.pmid: 12575908
references.citation: J Dairy Sci. 2006 Apr;89(4):1302-10
references.pmid: 16537962