title: Training pathologists in mouse pathology.
abstract: Expertise in the pathology of mice has expanded from traditional regulatory and drug safety screening (toxicologic pathology) primarily performed by veterinary pathologists to the highly specialized area of mouse research pathobiology performed by veterinary and medical pathologists encompassing phenotyping of mutant mice and analysis of research experiments exploiting inbred mouse strains and genetically engineered lines. With increasing use of genetically modified mice in research, mouse pathobiology and, by extension, expert mouse research-oriented pathologists have become integral to the success of basic and translational biomedical research. Training for today's research-oriented mouse pathologist must go beyond knowledge of anatomic features of mice and strain-specific background diseases to the specialized genetic nomenclature, husbandry, and genetics, including the methodology of genetic engineering and complex trait analysis. While training can be accomplished through apprenticeships in formal programs, these are often heavily service related and do not provide the necessary comprehensive training. Specialty courses and short-term mentoring with expert specialists are opportunities that, when combined with active practice and publication, will lead to acquisition of the skills required for cutting-edge mouse-based experimental science.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA. john.sundberg@jax.org
authors.forename: J P
authors.initials: JP
authors.lastname: Sundberg
authors.forename: J M
authors.initials: JM
authors.lastname: Ward
authors.forename: H
authors.initials: H
authors.lastname: HogenEsch
authors.forename: A Yu
authors.initials: AY
authors.lastname: Nikitin
authors.forename: P M
authors.initials: PM
authors.lastname: Treuting
authors.forename: J B
authors.initials: JB
authors.lastname: Macauley
authors.forename: P N
authors.initials: PN
authors.lastname: Schofield
mesh_terms: D000818:Animals; D005818:Genetic Engineering; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D010341:Pathology, Veterinary / Q000193:education*; D012106:Research / Q000193:education
references.citation: Vet Pathol. 2010 Nov;47(6):1016-20
references.pmid: 20587689
references.citation: Mamm Genome. 2008 Jun;19(6):413-9
references.pmid: 18797968
references.citation: Toxicol Pathol. 2007 Apr;35(3):447-8
references.pmid: 17474065
references.citation: Cancer Res. 2004 Apr 1;64(7):2307-16
references.pmid: 15059877
references.citation: Vet Pathol. 2009 Nov;46(6):1241-4
references.pmid: 19605899
references.citation: Comp Med. 2004 Dec;54(6):617-21
references.pmid: 15679258
references.citation: Nat Biotechnol. 2009 Jan;27(1):24-5
references.pmid: 19131991
references.citation: Nature. 2010 May 27;465(7297):410
references.pmid: 20505705
references.citation: J Invest Dermatol. 2009 Jul;129(7):1599-601
references.pmid: 19521404
references.citation: Nature. 2010 Jun 3;465(7298):526
references.pmid: 20520665
references.citation: J Mammary Gland Biol Neoplasia. 2000 Oct;5(4):421-37
references.pmid: 14973386
references.citation: Vet Pathol. 2009 Nov;46(6):1245-7
references.pmid: 19890103
references.citation: Cancer Res. 2004 Mar 15;64(6):2270-305
references.pmid: 15026373
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D512-5
references.pmid: 14681470
references.citation: J Vet Diagn Invest. 2007 Jul;19(4):455-6
references.pmid: 17609364
references.citation: Vet Pathol. 2009 Nov;46(6):1230-40
references.pmid: 19605915