title: [Impact of topic administration of nitric oxide donor gel in the clitoridian blood flow, assessed by Doppler ultra-sound].
abstract: OBJECTIVE
  This study aims to evaluate of the impact of NO molecules in Pluronic F-127 gel, applied topically in the clitoris, on the clitoridian blood flow of healthy volunteer women, using the Doppler ultra-sound.
  
  
  METHODS
  A total of 20 healthy women over 18 years old and sexually active with no sexual hormones alteration were enrolled. The Doppler ultra-sound procedure was performed on the artery of the clitoris in patients without the NO donor gel, and then after fifteen minutes of its application the same procedure was done again, to compare the values.
  
  
  RESULTS
  The hemodynamic results showed, that this formulation was responsible for the increase of the systolic and diastolic speeds in about 2,5 times after 15 min of the administration of the gel. The initial resistance index was increased in 1.2 due to the local venous congestion in only 15 min after the administration of gel. Indicating that this product can be used to promote the dilatation of the artery of the clitoris to treat women with sexual dysfunction.
  
  
  CONCLUSIONS
  The use of topic hidrogel as a donor drug in the clitoris of women resulting in a local vasodilatation, without systemic effects. These findings suggest that this preparation may be useful in the management of selected cases of female sexual dysfunction.
authors.affiliation: Sección Urología Femenina, División Urología, Facultad de Ciencias Médicas, Universidade Estadual de Campinas, Unicamp, Sao Paulo, Brasil.
authors.forename: S
authors.initials: S
authors.lastname: Souto
authors.forename: P
authors.initials: P
authors.lastname: Palma
authors.forename: C
authors.initials: C
authors.lastname: Riccetto
authors.forename: A B
authors.initials: AB
authors.lastname: Seabra
authors.forename: M
authors.initials: M
authors.lastname: Oliveira
authors.forename: T
authors.initials: T
authors.lastname: Palma
authors.forename: R
authors.initials: R
authors.lastname: Capmartin
mesh_terms: D000287:Administration, Topical; D002987:Clitoris / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects*; D005079:Excipients; D005260:Female; D005782:Gels; D006801:Humans; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D020442:Poloxamer; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000187:drug effects; D018608:Ultrasonography, Doppler; D055815:Young Adult
chemical_list: D005079:Excipients; D005782:Gels; D020030:Nitric Oxide Donors; D020442:Poloxamer