A rapid three-component MgI(2)-mediated synthesis of 3,3-pyrollidinyl spirooxindoles.
The rapid synthesis of 3,3-pyrollidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.
Helan
Victoria
V
GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA.
Mills
Allie
A
Drewry
David
D
Grant
Daniel
D
D007211:Indoles / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D007211:Indoles; D007454:Iodides; D017616:Magnesium Compounds; D013141:Spiro Compounds; C510205:magnesium iodide