Target gene identification via nuclear receptor binding site prediction.
In spite of numerous advances in recent years, the complete list of direct target genes for nuclear receptors remains elusive. The integrated application of new computational and experimental methods reviewed in this chapter provides insight into the complex network of regulatory pathways mediated by nuclear receptors which is expected to improve the understanding of the physiology and the pathology of metabolism, development, homeostasis, and other fundamental processes.
Varga
Gabor
G
Discovery Informatics, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA. gvarga@lilly.com
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D019295:Computational Biology / Q000379:methods*; D005796:Genes; D006801:Humans; D051379:Mice; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear