Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats.
In rat experimental varicocele, polydeoxyribonucleotide (PDRN) induces vascular endothelial growth factor (VEGF) production, thereby enhancing testicular function. This may point to a new therapeutic approach in human varicocele.
Minutoli
Letteria
L
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy.
Arena
Salvatore
S
Bonvissuto
Giulio
G
Bitto
Alessandra
A
Polito
Francesca
F
Irrera
Natasha
N
Arena
Francesco
F
Fragalà
Eugenia
E
Romeo
Carmelo
C
Nicotina
Piero Antonio
PA
Fazzari
Carmine
C
Marini
Herbert
H
Implatini
Alessandra
A
Grimaldi
Silvia
S
Cantone
Noemi
N
Di Benedetto
Vincenzo
V
Squadrito
Francesco
F
Altavilla
Domenica
D
Morgia
Giuseppe
G
D000818:Animals; D008297:Male; D011089:Polydeoxyribonucleotides / Q000494:pharmacology* / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D043705:Receptor, Adenosine A2A / Q000378:metabolism*; D013737:Testis / Q000473:pathology; D015854:Up-Regulation / Q000502:physiology*; D014646:Varicocele / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D011089:Polydeoxyribonucleotides; D020011:Protective Agents; D043705:Receptor, Adenosine A2A; D042461:Vascular Endothelial Growth Factor A