A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.
The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.
Saitoh
Tsuyoshi
T
Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.
Shimada
Chika
C
Takeiri
Masatoshi
M
Shiino
Mitsuhiro
M
Ohba
Shigeru
S
Obata
Rika
R
Ishikawa
Yuichi
Y
Umezawa
Kazuo
K
Nishiyama
Shigeru
S
D000818:Animals; D001549:Benzamides / Q000737:chemistry*; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006873:Hydroquinones / Q000737:chemistry*; D051379:Mice; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D001549:Benzamides; D003512:Cyclohexanones; D004852:Epoxy Compounds; D006873:Hydroquinones; D016328:NF-kappa B; C464444:dehydroxymethylepoxyquinomicin; D009569:Nitric Oxide