Platform technologies for tubular organ regeneration.
As a result of recent successes in regenerative medicine approaches to engineering multiple disparate tubular organs, methodology commonalities are emerging. Principal themes include the importance of a biodegradable scaffold seeded with a population of smooth muscle cells. Such composites trigger a regenerative response following in vivo implantation, resulting in de novo organogenesis. In this review, we examine bladder regeneration as a foundational platform technology to highlight key principles applicable to the regeneration of any tubular organ, and illustrate how these general concepts underlie current strategies to regenerate components of gastrointestinal, vascular, pulmonary and genitourinary systems. We focus on identifying the elements of this platform that have facilitated the transition of tubular organ regeneration from academic proof-of-concept to commercial viability.
Basu
Joydeep
J
Bioprocess Research and Assay Development, Tengion Inc., 3929 Westpoint Blvd., Suite G, Winston-Salem, NC 27103, USA. joydeep.basu@tengion.com
Ludlow
John W
JW
D000818:Animals; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering; D009927:Tissue and Organ Procurement