title: Scaffolding proteins and non-proliferative functions of ERK1/2.
abstract: Studies of ERK1/2 generally focus on the regulation of nuclear ERK1/2 function mainly related to proliferation, whereas less attention has been drawn to the role ERK1/2 plays in the cytosol. Scaffolding proteins for ERK1/2 have been shown to control the time point and also the intracellular location of ERK1/2 activation. Hence, by concentrating ERK1/2 within subcellular compartments, scaffolding proteins restrict the substrate specificity of ERK1/2 and thus optimize the cell response for specific signal transduction programs in order to manipulate specific cellular functions. We have presented evidence that the F-actin binding protein calponin represents a new type of ERK1/2 scaffold, controlling the activation of a subfraction of ERK1/2 which is connected solely to contractile and/or migratory events in a cell.
authors.affiliation: Department of Health Sciences; Boston University; Boston, MA USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Appel
authors.forename: Kathleen G
authors.initials: KG
authors.lastname: Morgan
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