A genomic glance at the components of the mRNA export machinery in Plasmodium falciparum.
Nuclear export of mRNAs is one of the steps critically important for gene expression and different steps of mRNA processing are linked to the export of the mRNA out of the nucleus. This coupling probably provides a quality control mechanism as well as a higher efficiency for the synthesis of mRNAs. The mRNA is synthesized in the nucleus and then exported to the cytoplasm through the nuclear pore complexes (NPCs), which are embedded in the nuclear envelope. The Mex67-Mtr2 complex in yeast and its counterpart Tap-p15 in higher eukaryotes function as an mRNA exporter through the NPC. Some of the DEAD box proteins such as UAP56 and Dbp5 have been implicated in mRNA export also. In this report using the bioinformatics approach we have analyzed the components of the mRNA export machinery in Plasmodium falciparum and also highlighted the salient features of some of the components. Further detailed studies on various components of nuclear mRNA export in Plasmodium falciparum will be essential to understand this important pathway.
Tuteja
Renu
R
Malaria Group; International Centre for Genetic Engineering and Biotechnology; Aruna Asaf Ali Marg, New Delhi India.
Mehta
Jatin
J
Gene. 2006 Jul 5;376(1):1-12
16713133
Mol Cell. 2001 Apr;7(4):887-98
11336711
RNA. 2003 Jul;9(7):847-57
12810918
Mol Cell Biol. 2004 Dec;24(23):10479-91
15542855
RNA. 1997 May;3(5):527-37
9149233
Cell Cycle. 2004 Dec;3(12):1612-37
15611647
J Biol Chem. 2000 Mar 24;275(12):8361-8
10722667
Genes Dev. 1997 Jul 15;11(14):1864-72
9242493
Nat Rev Mol Cell Biol. 2003 Oct;4(10):757-66
14570049
J Cell Biol. 2000 Aug 21;150(4):695-706
10952996
Parasitol Int. 2009 Dec;58(4):481-5
19751846
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2450-5
12604785
Mol Cell Proteomics. 2004 Feb;3(2):145-55
14645504
Arch Biochem Biophys. 2008 Oct 15;478(2):143-53
18722339
EMBO Rep. 2001 Oct;2(10):926-32
11571268
Mol Cell. 1998 Feb;1(3):359-69
9660920
Nature. 2001 Oct 11;413(6856):648-52
11675790
Traffic. 2005 Mar;6(3):187-98
15702987
EMBO J. 1997 Jun 2;16(11):3256-71
9214641
Nucleic Acids Res. 2009 Jan;37(Database issue):D211-5
18940856
Nat Cell Biol. 2006 Jul;8(7):711-6
16783363
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1030-5
11158589
EMBO J. 2001 Mar 15;20(6):1320-30
11250898
EMBO Rep. 2000 Jul;1(1):53-8
11256625
EMBO J. 1998 May 1;17(9):2651-62
9564047
J Cell Biol. 2003 Mar 31;160(7):1029-40
12668658
J Cell Biol. 1994 Mar;124(5):627-35
7509815
RNA. 2000 Apr;6(4):638-50
10786854
J Cell Biol. 1999 Feb 8;144(3):389-401
9971735
Mol Cell Biol. 2006 Dec;26(23):8697-709
17000757
Cell Cycle. 2010 Jan 1;9(1):104-20
20016272
Nature. 2002 Oct 3;419(6906):498-511
12368864
Science. 2006 Nov 3;314(5800):815-7
17082456
Annu Rev Cell Dev Biol. 1999;15:607-60
10611974
Mol Cell. 2004 Dec 3;16(5):749-60
15574330
Curr Opin Struct Biol. 2005 Apr;15(2):221-6
15837182
Annu Rev Biochem. 1995;64:865-96
7574503
Annu Rev Biochem. 1993;62:289-321
8352591
Nature. 2005 Mar 10;434(7030):214-7
15759000
J Cell Biol. 2000 Feb 21;148(4):635-51
10684247
Mol Cell Biol. 2000 Dec;20(23):8996-9008
11073998
Science. 2004 Jan 2;303(5654):95-8
14631048
Nature. 2002 May 16;417(6886):304-8
11979277
EMBO J. 1996 Oct 15;15(20):5584-94
8896452
Curr Biol. 1998 Mar 12;8(6):305-14
9512417
J Biol Chem. 1995 Feb 24;270(8):3619-24
7876098
Cell. 2006 Jun 16;125(6):1041-53
16777596
J Biol Chem. 2002 Dec 27;277(52):50597-606
12372823
Cell. 1997 Mar 7;88(5):585-8
9054498
Mol Cell. 2003 Mar;11(3):837-43
12667464
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12887-92
15306682
Trends Parasitol. 2009 Jan;25(1):37-43
18986839
EMBO J. 2002 Jun 17;21(12):2843-53
12065398
J Cell Biol. 1993 Nov;123(4):771-83
8227139
J Cell Biol. 2000 Nov 27;151(5):1057-66
11086007
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17628-33
15585580
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6436-40
6579529
Genes Dev. 2003 Feb 15;17(4):461-75
12600940
Cell. 2007 Aug 10;130(3):512-23
17693259
Cell. 2006 Aug 25;126(4):713-25
16923391
Curr Biol. 2001 Oct 30;11(21):1716-21
11696332
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
9254694
FEBS J. 2007 Sep;274(18):4670-9
17824953
Cell Mol Life Sci. 2003 Aug;60(8):1659-88
14504656
EMBO J. 2002 Mar 1;21(5):1177-87
11867546
Mol Cell. 2007 Dec 14;28(5):850-9
18082609
J Cell Biol. 2003 Aug 4;162(3):391-401
12885761
EMBO J. 2000 Nov 1;19(21):5824-34
11060033
Mol Cell Biol. 2002 Dec;22(23):8241-53
12417727
J Cell Biol. 1990 Oct;111(4):1571-82
2211825
Genes Dev. 2003 Dec 15;17(24):3011-6
14681208
EMBO J. 2008 Jan 9;27(1):277-89
18059478
Nucleic Acids Res. 2007 Jan;35(Database issue):D298-300
17135201
Nature. 2000 Sep 21;407(6802):401-5
11014198
Methods. 2006 Aug;39(4):329-41
16908185
Commun Integr Biol. 2009 May;2(3):245-60
19641745
Mol Cell. 2005 Nov 23;20(4):645-51
16307927
J Cell Biol. 2002 Sep 2;158(5):915-27
12196509