title: Hemodynamic effects of stenting on wide-necked intracranial aneurysms.
abstract: BACKGROUND
  Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.
  
  
  METHODS
  Three idealized plexiglass aneurismal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics (CFD) simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.
  
  
  RESULTS
  The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac. Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.
  
  
  CONCLUSIONS
  Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
authors.forename: Yi-sen
authors.initials: YS
authors.lastname: Zhang
authors.forename: Xin-jian
authors.initials: XJ
authors.lastname: Yang
authors.forename: Sheng-zhang
authors.initials: SZ
authors.lastname: Wang
authors.forename: Ai-ke
authors.initials: AK
authors.lastname: Qiao
authors.forename: Jia-liang
authors.initials: JL
authors.lastname: Chen
authors.forename: Kun-ya
authors.initials: KY
authors.lastname: Zhang
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Liu
authors.forename: Yu-jing
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
authors.forename: Chuan-hui
authors.initials: CH
authors.lastname: Li
mesh_terms: D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D057446:Hydrodynamics; D002532:Intracranial Aneurysm / Q000628:therapy*; D015607:Stents