title: Complete assignment of the 1H and 13C NMR spectra of antimicrobial 4-arylamino- 3-nitrocoumarin derivatives.
abstract: Herein, we describe the synthesis and complete assignment of the (1)H and (13)C NMR chemical shifts of a series of antimicrobial 4-arylamino-3-nitrocoumarin derivatives based on a combination of (1)H and (13)C NMR, (1)H-(1)H-COSY, NOESY, HSQC and HMBC experiments. Conformational effects upon the chemical shifts of the coumarin moiety arising from the anisotropy of the aryl side group are briefly discussed. This study provides the first complete and fully assigned NMR data for this important group of antimicrobial compounds and bridges the gap existing in the literature with regard to NMR structural data for 4-arylamino-3-nitrocoumarins.
authors.affiliation: Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia.
authors.forename: Vidoslav
authors.initials: V
authors.lastname: Dekić
authors.forename: Niko
authors.initials: N
authors.lastname: Radulović
authors.forename: Rastko
authors.initials: R
authors.lastname: Vukićević
authors.forename: Biljana
authors.initials: B
authors.lastname: Dekić
authors.forename: Danielle
authors.initials: D
authors.lastname: Skropeta
authors.forename: Radosav
authors.initials: R
authors.lastname: Palić
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry*; D002247:Carbon Isotopes; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011522:Protons; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: C446262:3-nitrocoumarin; D000890:Anti-Infective Agents; D002247:Carbon Isotopes; D003374:Coumarins; D009574:Nitro Compounds; D011522:Protons