title: Ameliorative effect of sesame lignans on nicotine toxicity in rats.
abstract: Nicotine causes oxidative and genotoxic damages in the tissues leading to several diseases. Any strategy through natural diet that prevents or slows the progression and severity of nicotine toxicity has a significant health impact. This work is designed to investigate natural antioxidants that play effective protective role against nicotine-induced toxicity. Experiments were conducted on male albino rats by injecting nicotine tartrate (3.5 mg/kg body wt./day for 15 days) subcutaneously and thereby supplementing sesame lignans (0.1 g/100g diet and 0.2 g/100g diet) orally to them. Significant (P<0.01) increase of total cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol, decrease of HDL-cholesterol, decrease in antioxidant enzymes and increase in concentration of lipid peroxidative product has been observed in plasma due to nicotine toxicity. Significant (P<0.01) decrease of total DNA contents and highly significant (P<0.001) DNA damage of liver tissue is also observed on nicotine treatment. Sesame lignans minimizes the above mentioned effects. The nicotine-induced oxidative and genotoxic damages on the tissues can be effectively attenuated by sesame lignans supplemented diet.
authors.affiliation: Department of Chemical Technology, University of Calcutta, Kolkata, India. kris_ami@yahoo.co.in
authors.forename: Krishna
authors.initials: K
authors.lastname: Chattopadhyay
authors.forename: Srinath
authors.initials: S
authors.lastname: Mondal
authors.forename: Brajadulal
authors.initials: B
authors.lastname: Chattopadhyay
authors.forename: Santinath
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D020552:Comet Assay; D004247:DNA / Q000032:analysis; D004249:DNA Damage; D004336:Drug Antagonism; D017705:Lignans / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009153:Mutagens / Q000633:toxicity*; D009538:Nicotine / Q000633:toxicity*; D018722:Nicotinic Agonists / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D031685:Sesamum / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017705:Lignans; D008055:Lipids; D009153:Mutagens; D018722:Nicotinic Agonists; D010936:Plant Extracts; D008315:Malondialdehyde; D009538:Nicotine; D004247:DNA; D002374:Catalase; D013482:Superoxide Dismutase