Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.
Fleming
Fraser F
FF
Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530, USA. flemingf@duq.edu
Yao
Lihua
L
Ravikumar
P C
PC
Funk
Lee
L
Shook
Brian C
BC
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002403:Cathepsins / Q000037:antagonists & inhibitors; D002491:Central Nervous System Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D019380:Anti-HIV Agents; D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D054873:Dipeptidyl-Peptidase IV Inhibitors; D009570:Nitriles; D014969:Xanthine Oxidase; D002403:Cathepsins
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