Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus Willd on learning and memory in young and old mice: a comparative evaluation.
A dose dependent enhancement of memory was observed with A. racemosus and C. pluricaulis treatment as compared to control group when tested on second day. A. racemosus and C. pluricaulis at the dose of 200 mg/kg, po showed significantly higher percent retentions, than piracetam. Multiple treatment with A. racemosus and C. pluricaulis for three days also demonstrated significant dose dependent increase in percent retentions as compared to control group. The effect was more prominent with C. pluricaulis as compared with piracetam and A. racemosus. A significantly lower percent retention in aged mice was observed as compared to young mice. Aged mice (18-20 months) showed higher transfer latency (TL) values on first and second day (after 24 h) as compared to young mice, indicating impairment in learning and memory. Pretreatment with A. racemosus and C. pluricaulis for 7 days enhanced memory in aged mice, as significant increase in percent retention was observed. Significantly higher retention was observed with C. pluricaulis (200 mg/kg; po) as compared with piracetam (10 mg/kg/; po). Post-trial administration of C. pluricaulis and A. racemosus extract demonstrated significant decrease in latency time during retention trials. Hippocampal regions associated with the learning and memory functions showed dose dependent increase in AChE activity in CA 1 with A. reacemosus and CA3 area with C. pluracaulis treatment. The underlying mechanism of these actions of A. racemosus and C. pluricaulis may be attributed to their antioxidant, neuroprotective and cholinergic properties.
Sharma
Komal
K
B.N. PG College of Pharmacy, Udaipur 313 001, India.
Bhatnagar
Maheep
M
Kulkarni
S K
SK
D000109:Acetylcholine / Q000032:analysis; D000375:Aging / Q000523:psychology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018678:Cholinergic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D031254:Convolvulus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D007859:Learning Disabilities / Q000188:drug therapy* / Q000473:pathology; D019668:Liliaceae / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008515:Medicine, Ayurvedic; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D018697:Nootropic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010889:Piracetam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012997:Solvents
D000975:Antioxidants; D018678:Cholinergic Agents; D018697:Nootropic Agents; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D000109:Acetylcholine; D010889:Piracetam