title: Impact of measuring fractional flow reserve on decision-making in the cath lab in a cohort of patients being considered for coronary revascularization.
abstract: BACKGROUND
  Fractional flow reserve (FFR) is an accepted standard to detect the functional significance of coronary stenoses. Recent trials suggest that revascularization of moderate coronary stenoses can be safely deferred if the FFR is > or = 0.75 and FFR can be used to guide therapy in multivessel disease.
  
  
  OBJECTIVE
  In a cohort of patients with moderate angiographic coronary disease, we sought to examine the influence of FFR on lesion revascularization and the impact of multivessel FFR assessment on revascularization strategy.
  
  
  RESULTS
  Patients with FFR measurements taken between April 2005 to October 2007 were included. Out of 300 cases performed in this time, 264 patients were included. Patients were 62 +/- 11 years and 1.3 +/- 0.54 vessels were examined per case. 92.7% of lesions with a FFR < 0.75 underwent revascularizati on an d 93% of lesions with a FFR > or = 0.75 had intervention deferred. FFR was 0.71 +/- 0.07 in the revascularization group (9 coronary artery bypass graft surgery, 64 percutaneous coronary interventions) and 0.86 +/- 0.06 in the deferred group (p < 0.001). Overall, 75% of patients avoided revascularization of at least one vessel on the basis of the FFR.
  
  
  CONCLUSIONS
  Measurement of FFR is clinically useful with a high impact on clinical decision-making in the catheterization laboratory. FFR can be used to reclassify patients with multivessel stenoses, reducing the need for revascularization in the majority of cases.
authors.affiliation: The Rayne Institute, 3rd Floor Lambeth Wing, St. Thomas' Hospital, KCL, London, SE1 7EH, United Kingdom. tim.lockie@gstt.nhs.uk
authors.forename: Tim
authors.initials: T
authors.lastname: Lockie
authors.forename: Divaka
authors.initials: D
authors.lastname: Perera
authors.forename: Kalpa
authors.initials: K
authors.lastname: De Silva
authors.forename: Ian
authors.initials: I
authors.lastname: Webb
authors.forename: Suzanne
authors.initials: S
authors.lastname: Pattinson
authors.forename: Simon
authors.initials: S
authors.lastname: Redwood
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000379:methods*; D015331:Cohort Studies; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D003657:Decision Making; D005260:Female; D053805:Fractional Flow Reserve, Myocardial / Q000502:physiology*; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D012720:Severity of Illness Index; D015607:Stents