Inherited predisposition to cancer: introduction and overview.
The past three decades have witnessed an explosion in information regarding the genetic mutations underlying predisposition to common malignancies. Discoveries are now being made regarding genomic variants associated with disease risk for, and outcome following, treatment for cancer. Responsible translation of these discoveries to medical practice requires attention to principles of clinical utility as well as social and ethical aspects.
Robson
Mark
M
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Offit
Kenneth
K
D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D017410:Practice Guidelines as Topic; D057285:Precision Medicine