The influence of diet on the assimilation efficiency of 47 polychlorinated biphenyl congeners in Japanese koi (Cyprinus carpio).
The influence of diet on polychlorinated biphenyl (PCB) assimilation was investigated by measuring dietary assimilation efficiencies (AEs) for 47 PCB congeners in juvenile koi (Cyprinus carpio) fed five experimental diets. Two of the diets were naturally contaminated and were obtained by collecting mayflies from Lake Erie (ON, Canada) and emerald shiners from the Detroit River (MI, USA). The remaining diets consisted of commercial fish pellets (lipid contents from 6.7 to 24%) that were contaminated by spiking with a PCB mixture. Experimental fish were held individually to quantify the amount of food consumed per fish and, following a 48-h fasting period to facilitate food digestion and assimilation; AEs were determined by mass balance. Fish fed the benthic invertebrate food exhibited the highest PCB AEs (70-101%) and were significantly elevated compared to the other diet treatments (AEs ranging from 23 to 87%). The PCB AEs for fish fed emerald shiners did not differ from those fed pellet formulations. Variation among PCB AEs was not related to diet lipid content. For all diet treatments, PCB AEs were significantly related to chemical hydrophobicity. The relationship between chemical AE and n-octanol/water partition coefficient (K(OW)) was best explained by a linear model compared to a two-phase resistance model. Overall, PCB AEs were observed to be dependent on both diet type and chemical hydrophobicity, with both factors contributing nearly equally to the variation measured in this toxicokinetic parameter.
Liu
Jian
J
Great Lakes Institute for Environmental Research, University of Windsor, Windsor, 401 Sunset Avenue, Windsor, ON, Canada, N9B 3P4.
Haffner
G Douglas
GD
Great Lakes Institute for Environmental Research, University of Windsor, Windsor, 401 Sunset Avenue, Windsor, ON, Canada, N9B 3P4.
Drouillard
Ken G
KG
Great Lakes Institute for Environmental Research, University of Windsor, Windsor, 401 Sunset Avenue, Windsor, ON, Canada, N9B 3P4.
D000818:Animals; D002347:Carps / Q000378:metabolism*; D004032:Diet; D057927:Hydrophobic and Hydrophilic Interactions; D011078:Polychlorinated Biphenyls / Q000737:chemistry / Q000493:pharmacokinetics*
D011078:Polychlorinated Biphenyls
Giesy JP, Kannan K. 1998. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): Implications for risk assessment. Crit Rev Toxicol 28: 511-569.
Liem AKD, Furst P, Rappe C. 2000. Exposure of populations to dioxins and related compounds. Food Addit Contam: Part A 17: 241-259.
Harrison HL, Loucks OL, Mitchell JW, Parkhurs DF, Tracy CR, Watts DG, Yannacon VJ. 1970. Systems studies of DDT transport. Science 170: 503-508.
Arnot JA, Gobas FAPC. 2006. A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms. Environ Rev 14: 257-297.
Qiao P, Gobas FAPC, Farrell AP. 2000. Relative contributions of aqueous and dietary uptake of hydrophobic chemicals to the body burden in juvenile rainbow trout. Arch Environ Contam Toxicol 39: 369-377.
Gobas FAPC, Clark KE, Shu WY, Mackay D. 1989. Bioconcentration of polybrominated benzenes and biphenyls and related superhydrophobic chemicals in fish: Role of bioavailability and elimination into the feces. Environ Toxicol Chem 8: 231-245.
Saloranta TM, Nae K, Barton DN, Armitage JM, Cousins IT, Haario H. 2008. Modeling the effects and uncertainties of contaminated sediment remediation scenarios in a Norwegian fjord by Markov chain Monte Carlo simulation. Environ Sci Technol 42: 200-206.
Gobas FAPC, Z'Graggen M, Zhang X. 1995. Time response of the Lake Ontario ecosystem to virtual elimination of PCBs. Environ Sci Technol 29: 2038-2046.
Arnot JA, Mackay D. 2008. Policies for chemical hazard and risk priority setting: Can persistence, bioaccumulation, toxicity, and quantity information be combined? Environ Sci Technol 42: 4648-4654.
Feldman RS, Titus JE. 2001. Polychlorinated biphenyl accumulation differs among pumpkinseed sunfish during experimental field exposure: the role of invertebrate prey. Aquat Toxicol 51: 389-404.
Connolly JP, Pedersen CJ. 1988. A thermodynamic-based evaluation of organic chemical accumulation in aquatic organisms. Environ Sci Technol 22: 99-103.
Barber MC. 2008. Dietary uptake models used for modeling the bioaccumulation of organic contaminants in fish. Environ Toxicol Chem 27: 755-777.
Arnot JA, Gobas FAPC. 2004. A food web bioaccumulation model for organic chemicals in aquatic ecosystems. Environ Toxicol Chem 23: 2343-2355.
Drouillard KG, Paterson G, Haffner GD. 2009. A combined food web toxicokinetics and species bioenergetic model for predicting seasonal PCB elimination by yellow perch (Perca flavescens). Environ Sci Technol 43: 2858-2864.
Gobas FAPC, Muir DCG, Mackay D. 1988. Dynamics of dietary bioaccumulation and fecal elimination of hydrophobic organic chemicals in fish. Chemosphere 17: 943-962.
Burreau S, Axelman J, Broman D, Jakobsson E. 1997. Dietary uptake in pike (Esox lucius) of some polychlorinated biphenyls, polychlorinated naphthalenes, and polybrominated diphenyl ethers administered in natural diet. Environ Toxicol Chem 16: 2508-2513.
Fisk AT, Norstrom RJ, Cymbalisty CD, Muir DCG. 1998. Dietary accumulation and depuration of hydrophobic organochlorines: Bioaccumulation parameters and their relationship with the octanol/water partition coefficient. Environ Toxicol Chem 17: 951-961.
Tanabe S, Maruyama K, Tatsukawa R. 1982. Absorption efficiency and biological half-lives of individual chlorobiphenyls in carp (Cyprinus carpio) orally exposed to Kanechlor products. Agric Biol Chem 46: 891-898.
Gobas FAPC, McCorquodale JR, Haffner GD. 1993. Intestinal absorption and biomagnification of organochlorines. Environ Toxicol Chem 12: 567-576.
Gobas FAPC, Wilcockson JB, Russell RW, Haffner GD. 1999. Mechanism of biomagnification in fish under laboratory and field conditions. Environ Sci Technol 33: 133-141.
Clark KE, Gobas FAPC, Mackay D. 1990. Model of organic chemical uptake and clearance by fish from food and water. Environ Sci Technol 24: 1203-1213.
Dabrowska H, Fisher SW, Dabrowska K, Staubus AE. 1999. Dietary uptake efficiency of 2,2′,4,4′,5,5′-hexachlorobiphenyl in yellow perch and rainbow trout: Role of dietary and body lipids. Environ Toxicol Chem 18: 938-945.
Nichols JW, Fitzsimmons PN, Whiteman FW, Kuehl DW, Butterworth BC, Jenson CT. 2001. Dietary uptake kinetics of 2,2′,5,5′-tetrachlorobiphenyl in rainbow trout. Drug Metab Dispos 29: 1013-1022.
Drouillard KG, Ciborowski JJH, Lazar R, Haffner GD. 1996. Estimation of the uptake of organochlorides by the Mayfly Hexagenia limbata (Ephemeroptera: Ephemeridae). J Gt Lakes Res 22: 26-35.
Drouillard KG, Tomczak M, Reitsma S, Haffner GD. 2006. A river wide survey of polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and selected organochlorine pesticide residues in sediments of the Detroit River-1999. J Gt Lakes Res 32: 209-226.
Stalling DL, Norstrom RJ, Smith LM, Simon M. 1985. Patterns of PCDD, PCDF, and PCB contamination in Great Lakes fish and birds and their characterization by principal components analysis. Chemosphere 14: 627-643.
Bruggeman WA, Martron LBJM, Kooiman D, Hutzinger O. 1981. Accumulation and elimination kinetics of di-, tri- and tetra chlorobiphenyls by goldfish after dietary and aqueous exposure. Chemosphere 10: 811-832.
Daley JM, Leadley TA, Drouillard KG. 2009. Bioamplification of nine polychlorinated biphenyl (PCB) congeners in yellow perch eggs during incubation. Chemosphere 75: 1500-1505.
Drouillard KG, Hagen H, Haffner GD. 2004. Evaluation of chloroform/methanol and dichloromethane/hexane extractable lipids as surrogate measures of sample partition capacity for organochlorines in fish tissues. Chemosphere 55: 395-400.
Lazar R, Edwards RC, Metcalfe CD, Gobas FAPC, Haffner GD. 1992. A simple, novel method for the quantitative-analysis of coplanar (nonorthosubstituted) polychlorinated-biphenyls in environmental samples. Chemosphere 25: 493-504.
Clark KE, Mackay D. 1991. Dietary uptake and biomagnifications of four chlorinated hydrocarbons by guppies. Environ Toxicol Chem 10: 1205-1217.
Bruggeman WA, Opperhuizen A, Wijbenga A, Hutzinger O. 1984. Bioaccumulation of super-lipophilic chemicals in fish. Toxicol Environ Chem 7: 173-189.
Gobas FAPC, Zhang X, Wells R. 1993. Gastrointestinal magnification: The mechanism of biomagnification and food chain accumulation of organic chemicals. Environ Sci Technol 27: 2855-2863.
Buckman AH, Brown SB, Hoekstra PF, Solomon KR, Fisk AT. 2004. Toxicokinetics of three polychlorinated biphenyl technical mixtures in rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem 23: 1725-1736.
Sharifi M, Connell DW, Gabric A. 1997. Influence of dietary fat on the intestinal absorption of lipophilic compounds in goldfish (Carassius auratus). Ecotoxicol Environ Saf 38: 316-321.
Hawker DW, Connell DW. 1985. Relationships between partition coefficient, uptake rate constant, clearance rate constant, and time to equilibrium for bioaccumulation. Chemosphere 14: 1205-1219.
Iannuzzi TJ, Harrington NW, Shear NM, Curry CL, Carlson-Lynch H, Henning MH, Su SH, Rabbe DE. 1996. Distributions of key exposure factors controlling the uptake of xenobiotic chemicals in an estuarine food web. Environ Toxicol Chem 15: 1979-1992.
Ciavatta S, Lovato T, Ratto M, Pastres R. 2009. Global uncertainty and sensitivity analysis of a food web bioaccumulation model. Environ Toxicol Chem 28: 718-732.