title: Cognitive dysfunction and associated factors in patients with chronic schizophrenia.
abstract: BACKGROUND
  Deficits in neurocognitive function are a hallmark of schizophrenia. They are associated with clinical manifestations and the course of the illness. A study of cognitive dysfunction in Indian patients with schizophrenia is of significance in view of a more benign course and outcome of the illness in this region.
  
  
  OBJECTIVE
  To study cognitive deficits and associated factors in patients with chronic schizophrenia and compare them with those in the normal population.
  
  
  METHODS
  We compared 100 patients with chronic schizophrenia with 100 matched normal controls on multiple measures of attention, executive function and memory.
  
  
  RESULTS
  Compared to normal individuals, patients with schizophrenia performed poorly in all cognitive tests. Cognitive deficits in patients were related to gender, education, age, duration of illness, and presence of positive and negative symptoms.
  
  
  CONCLUSIONS
  The neurocognitive profile of Indian patients with chronic schizophrenia resembles those of patients in developed countries.
authors.affiliation: Psychologist, Hunter New England Area Health Service, Australia.
authors.forename: Latha
authors.initials: L
authors.lastname: Srinivasan
authors.forename: R
authors.initials: R
authors.lastname: Thara
authors.forename: S N
authors.initials: SN
authors.lastname: Tirupati
references.citation: Biol Psychiatry. 2000 Jul 15;48(2):137-46
references.pmid: 10903410
references.citation: Dev Neuropsychol. 2003;23(3):317-37
references.pmid: 12740188
references.citation: J Clin Psychiatry. 1999;60 Suppl 23:25-8
references.pmid: 10625197
references.citation: Psychiatr Serv. 2003 Aug;54(8):1129-35
references.pmid: 12883141
references.citation: Arch Clin Neuropsychol. 1987;2(1):13-32
references.pmid: 14589568
references.citation: Schizophr Bull. 1987;13(2):261-76
references.pmid: 3616518
references.citation: Arch Gen Psychiatry. 1997 Feb;54(2):159-65
references.pmid: 9040284
references.citation: Acta Psychiatr Scand. 1999 Aug;100(2):85-95
references.pmid: 10480194
references.citation: Schizophr Res. 1997 May 3;25(1):1-10
references.pmid: 9176922
references.citation: Schizophr Res. 2004 May 1;68(1):1-9
references.pmid: 15037334
references.citation: Am J Psychiatry. 1996 Mar;153(3):321-30
references.pmid: 8610818
references.citation: Appl Neuropsychol. 2003;10(3):153-62
references.pmid: 12890641
references.citation: Neurology. 2003 Jun 24;60(12):1909-15
references.pmid: 12821732
references.citation: Schizophr Bull. 2000;26(1):119-36
references.pmid: 10755673
references.citation: J Psychiatry Neurosci. 2000 Mar;25(2):117-24
references.pmid: 10740985
references.citation: Neuropsychologia. 2000;38(12):1565-75
references.pmid: 11074079
references.citation: Indian J Psychiatry. 1993 Jan;35(1):27-30
references.pmid: 21776163
references.citation: Curr Psychiatry Rep. 2001 Oct;3(5):423-8
references.pmid: 11559481
references.citation: Arch Gen Psychiatry. 1991 Mar;48(3):239-46
references.pmid: 1671741
references.citation: Acta Psychiatr Scand Suppl. 2000;401:3-38
references.pmid: 10887978