title: Erythropoietin is involved in angiogenesis in human primary melanoma.
abstract: In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis and tumour thickness. These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis.
authors.affiliation: Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Perra
authors.forename: Vito
authors.initials: V
authors.lastname: Longo
authors.forename: Cristina
authors.initials: C
authors.lastname: Maxia
authors.forename: Tiziana
authors.initials: T
authors.lastname: Annese
authors.forename: Franca
authors.initials: F
authors.lastname: Piras
authors.forename: Daniela
authors.initials: D
authors.lastname: Murtas
authors.forename: Paola
authors.initials: P
authors.lastname: Sirigu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004921:Erythropoietin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology; D017467:Receptors, Erythropoietin / Q000378:metabolism; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D017467:Receptors, Erythropoietin; D004921:Erythropoietin
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