Effects of feed-borne Fusarium mycotoxins and an organic mycotoxin adsorbent on immune cell dynamics in the jejunum of chickens infected with Eimeria maxima.
An experiment was conducted to explore the effects of Fusarium mycotoxins, common animal feed contaminants, on intestinal immune responses to coccidia (Eimeria) in chickens. Effects of feed-borne Fusarium mycotoxins and a polymeric glucomannan mycotoxin adsorbent (GMA) on immune cell populations were studied in the jejunum of broiler breeder pullets using an Eimeria maxima infection model. Birds were fed a control diet, a diet naturally contaminated with Fusarium mycotoxins, contaminated diet plus 0.2% GMA, or control diet plus 0.2% GMA. Contaminated diets contained up to 6.5μg/g deoxynivalenol (DON), 0.47μg/g 15-acetyl-DON and 0.73μg/g zearalenone. Birds received a primary oral inoculation (1000 oocysts/bird) with E. maxima USDA strain 68 at 2 weeks of age and a secondary oral inoculation (30,000 oocysts/bird) with the same strain at 4 weeks of age. Diet-related differences in CD4(+) cell, CD8(+) cell and macrophage recruitment pattern into the jejunum were observed following both the primary and secondary infections. It was concluded that feed-borne Fusarium mycotoxins and GMA have the potential to modulate immune response to coccidial infections.
Girgis
George N
GN
Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada N1G 2W1.
Barta
John R
JR
Girish
Channarayapatna K
CK
Karrow
Niel A
NA
Boermans
Herman J
HJ
Smith
Trevor K
TK
D000327:Adsorption; D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002645:Chickens / Q000276:immunology* / Q000469:parasitology*; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D004539:Eimeria; D005260:Female; D005506:Food Contamination; D005670:Fusarium / Q000472:pathogenicity*; D007583:Jejunum / Q000187:drug effects* / Q000276:immunology* / Q000469:parasitology; D008351:Mannans / Q000008:administration & dosage; D009183:Mycotoxins / Q000633:toxicity*; D011201:Poultry Diseases / Q000276:immunology* / Q000469:parasitology
D008351:Mannans; D009183:Mycotoxins; C022901:(1-6)-alpha-glucomannan