title: Neuroeconomic approaches to mental disorders.
abstract: The pervasiveness of decision-making in every area of human endeavor highlights the importance of understanding choice mechanisms and their detailed relationship to underlying neurobiological function. This review surveys the recent and productive application of game-theoretic probes (economic games) to mental disorders. Such games typically possess concrete concepts of optimal play, thus providing quantitative ways to track when subjects' choices match or deviate from optimal. This feature equips economic games with natural classes of control signals that should guide learning and choice in the agents that play them. These signals and their underlying physical correlates in the brain are now being used to generate objective biomarkers that may prove useful for exposing and understanding the neurogenetic basis of normal and pathological human cognition. Thus, game-theoretic probes represent some of the first steps toward producing computationally principled, objective measures of cognitive function and dysfunction useful for the diagnosis, treatment, and understanding of mental disorders.
authors.affiliation: Department of Neuroscience and Computational Psychiatry Unit, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Kenneth T
authors.initials: KT
authors.lastname: Kishida
authors.forename: Brooks
authors.initials: B
authors.lastname: King-Casas
authors.forename: P Read
authors.initials: PR
authors.lastname: Montague
mesh_terms: D000818:Animals; D003657:Decision Making; D004467:Economics; D005717:Games, Experimental; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000523:psychology*; D009488:Neurosciences
references.citation: J Affect Disord. 2003 Sep;76(1-3):183-9
references.pmid: 12943948
references.citation: Psychopharmacology (Berl). 2002 Jan;159(2):216-21
references.pmid: 11862352
references.citation: J Neurosci. 2010 Mar 3;30(9):3339-46
references.pmid: 20203193
references.citation: Biol Psychiatry. 2003 Jan 1;53(1):65-74
references.pmid: 12513946
references.citation: Neuropsychopharmacology. 2003 Apr;28(4):795-806
references.pmid: 12655327
references.citation: Biol Psychiatry. 2002 Jun 15;51(12):995-1004
references.pmid: 12062884
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4389-94
references.pmid: 20160081
references.citation: Neuroimage. 2004 Aug;22(4):1694-703
references.pmid: 15275925
references.citation: Schizophr Bull. 2005 Jan;31(1):21-42
references.pmid: 15888423
references.citation: Neuron. 2004 Oct 14;44(2):365-78
references.pmid: 15473973
references.citation: Science. 2005 Apr 1;308(5718):78-83
references.pmid: 15802598
references.citation: Neuron. 2008 Feb 7;57(3):463-73
references.pmid: 18255038
references.citation: Neuroimage. 2006 Nov 1;33(2):725-31
references.pmid: 16959497
references.citation: Neuron. 2002 Jul 18;35(2):395-405
references.pmid: 12160756
references.citation: Drug Alcohol Depend. 2008 Aug 1;96(3):256-62
references.pmid: 18468814
references.citation: Am J Psychiatry. 1996 May;153(5):714-7
references.pmid: 8615422
references.citation: J Cogn Neurosci. 2004 Dec;16(10):1746-72
references.pmid: 15701226
references.citation: Trends Cogn Sci. 2003 Jan;7(1):38-42
references.pmid: 12517357
references.citation: Neuroimage. 2007 Oct 15;38(1):223-7
references.pmid: 17707125
references.citation: J Neurophysiol. 1998 Jul;80(1):1-27
references.pmid: 9658025
references.citation: JAMA. 2003 Sep 3;290(9):1153-4
references.pmid: 12952995
references.citation: Neuropsychologia. 2004;42(9):1168-77
references.pmid: 15178169
references.citation: Nature. 2006 Aug 31;442(7106):1042-5
references.pmid: 16929307
references.citation: Neuron. 2006 May 18;50(4):655-63
references.pmid: 16701214
references.citation: J Autism Dev Disord. 2007 Aug;37(7):1279-88
references.pmid: 17080271
references.citation: Neuroreport. 2009 Mar 4;20(4):388-92
references.pmid: 19218873
references.citation: Annu Rev Neurosci. 2006;29:417-48
references.pmid: 16776592
references.citation: Annu Rev Neurosci. 2000;23:473-500
references.pmid: 10845072
references.citation: Biol Psychiatry. 2007 Jun 1;61(11):1260-71
references.pmid: 17046722
references.citation: J Neurosci. 1996 Mar 1;16(5):1936-47
references.pmid: 8774460
references.citation: Science. 2008 Jun 27;320(5884):1739
references.pmid: 18535210
references.citation: Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3721-6
references.pmid: 18316737
references.citation: J Cogn Neurosci. 2002 Jul 1;14(5):785-94
references.pmid: 12167262
references.citation: Drug Alcohol Depend. 2007 Feb 23;87(1):94-7
references.pmid: 16930862
references.citation: Science. 2009 May 15;324(5929):948-50
references.pmid: 19443783
references.citation: PLoS One. 2009 May 20;4(5):e5535
references.pmid: 19461999
references.citation: J Abnorm Psychol. 2008 May;117(2):406-13
references.pmid: 18489216
references.citation: Science. 2007 Jan 26;315(5811):515-8
references.pmid: 17255512
references.citation: Nat Neurosci. 2004 Apr;7(4):404-10
references.pmid: 15004564
references.citation: Ann N Y Acad Sci. 2008 Oct;1141:270-83
references.pmid: 18991963
references.citation: Brain. 2008 May;131(Pt 5):1311-22
references.pmid: 18390562
references.citation: Nature. 2005 Jun 2;435(7042):673-6
references.pmid: 15931222
references.citation: Trends Cogn Sci. 2007 Apr;11(4):153-7
references.pmid: 17300981
references.citation: Science. 1981 Mar 27;211(4489):1390-6
references.pmid: 7466396
references.citation: Neuron. 2002 Oct 10;36(2):265-84
references.pmid: 12383781
references.citation: Annu Rev Psychol. 2004;55:87-124
references.pmid: 14744211
references.citation: J Neurosci. 2007 Aug 1;27(31):8366-77
references.pmid: 17670983
references.citation: J Affect Disord. 2004 Oct 15;82(2):203-8
references.pmid: 15488248
references.citation: Neuroimage. 2004 Oct;23(2):744-51
references.pmid: 15488424
references.citation: Science. 2003 Jun 13;300(5626):1755-8
references.pmid: 12805551
references.citation: Nat Rev Neurosci. 2005 May;6(5):363-75
references.pmid: 15832198
references.citation: Drug Alcohol Depend. 2007 Oct 8;90(2-3):183-92
references.pmid: 17434690
references.citation: Nature. 2006 Jan 26;439(7075):466-9
references.pmid: 16421576
references.citation: Annu Rev Neurosci. 2005;28:109-26
references.pmid: 16033325
references.citation: Curr Opin Neurobiol. 2008 Apr;18(2):117-9
references.pmid: 18771730
references.citation: Nat Neurosci. 2005 Nov;8(11):1611-8
references.pmid: 16222226
references.citation: Soc Cogn Affect Neurosci. 2006 Sep;1(2):136-42
references.pmid: 18985124
references.citation: Nature. 2004 Oct 14;431(7010):760-7
references.pmid: 15483596
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):545-56
references.pmid: 18545266
references.citation: Proc Natl Acad Sci U S A. 1950 Jan;36(1):48-9
references.pmid: 16588946
references.citation: Neuron. 2008 May 22;58(4):639-50
references.pmid: 18498743
references.citation: J Psychopharmacol. 2005 Jul;19(4):366-74
references.pmid: 15982991
references.citation: Proc Natl Acad Sci U S A. 2007 May 29;104(22):9493-8
references.pmid: 17519340
references.citation: Neuropsychologia. 2000;38(1):11-21
references.pmid: 10617288
references.citation: Neuroimage. 2005 Dec;28(4):797-814
references.pmid: 16290016
references.citation: Horm Behav. 2010 Mar;57(3):368-74
references.pmid: 20080100
references.citation: Neuroimage. 2006 May 15;31(1):440-57
references.pmid: 16466680
references.citation: Neuron. 2007 Oct 4;56(1):14-8
references.pmid: 17920011
references.citation: Schizophr Res. 1999 Jan 4;35(1):69-75
references.pmid: 9988842
references.citation: J Abnorm Psychol. 1980 Jun;89(3):320-32
references.pmid: 7410699
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15631-4
references.pmid: 17909184
references.citation: Neuroimage. 2000 Feb;11(2):157-66
references.pmid: 10679187
references.citation: Neuron. 2006 Mar 2;49(5):765-75
references.pmid: 16504951
references.citation: Science. 1974 Sep 27;185(4157):1124-31
references.pmid: 17835457
references.citation: Biol Psychiatry. 2004 Jun 15;55(12):1179-87
references.pmid: 15184037
references.citation: Science. 2005 Dec 9;310(5754):1680-3
references.pmid: 16339445
references.citation: Biol Psychiatry. 2008 Jun 1;63(11):1054-60
references.pmid: 17949691
references.citation: Neurosci Biobehav Rev. 2009 Mar;33(3):305-13
references.pmid: 18930761
references.citation: Brain Res Brain Res Rev. 2003 Oct;43(2):224-30
references.pmid: 14572916
references.citation: Neuron. 2008 Sep 11;59(5):829-38
references.pmid: 18786365
references.citation: Arch Gen Psychiatry. 2005 Jul;62(7):761-8
references.pmid: 15997017
references.citation: Neuroreport. 2009 Jul 15;20(11):984-9
references.pmid: 19521264
references.citation: J Theor Biol. 1964 Jul;7(1):17-52
references.pmid: 5875340
references.citation: Neuropsychopharmacology. 2006 May;31(5):1075-84
references.pmid: 16407905
references.citation: J Neurosci. 2009 Mar 18;29(11):3627-41
references.pmid: 19295166
references.citation: Science. 2006 Jan 6;311(5757):47-52
references.pmid: 16400140
references.citation: J Theor Biol. 1964 Jul;7(1):1-16
references.pmid: 5875341
references.citation: Neuron. 2001 Feb;29(2):537-45
references.pmid: 11239442
references.citation: Science. 2009 May 29;324(5931):1160-4
references.pmid: 19478175
references.citation: Science. 2004 Jun 18;304(5678):1782-7
references.pmid: 15205529
references.citation: Science. 1997 Mar 14;275(5306):1593-9
references.pmid: 9054347
references.citation: Nature. 1999 Jul 15;400(6741):233-8
references.pmid: 10421364
references.citation: Annu Rev Psychol. 2007;58:259-89
references.pmid: 17002553
references.citation: Neuron. 2005 Jul 7;47(1):129-41
references.pmid: 15996553
references.citation: Nat Neurosci. 2008 Apr;11(4):514-20
references.pmid: 18311134
references.citation: Psychopharmacology (Berl). 2002 May;161(3):324-30
references.pmid: 12021836
references.citation: Drug Alcohol Depend. 2005 Apr 4;78(1):83-90
references.pmid: 15769561
references.citation: J Pers Disord. 2009 Aug;23(4):399-409
references.pmid: 19663659
references.citation: Science. 1999 Nov 26;286(5445):1692-5
references.pmid: 10576727
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3788-92
references.pmid: 20142490
references.citation: Trends Cogn Sci. 2003 Dec;7(12):527-33
references.pmid: 14643368
references.citation: Neuroimage. 2003 Aug;19(4):1439-48
references.pmid: 12948701
references.citation: Science. 2004 Oct 15;306(5695):447-52
references.pmid: 15486291
references.citation: Nat Neurosci. 2005 Sep;8(9):1129-30
references.pmid: 16127442
references.citation: Judgm Decis Mak. 2008 Oct 1;3(7):483-492
references.pmid: 20305741
references.citation: Neuroimage. 2001 Jul;14(1 Pt 1):170-81
references.pmid: 11525326
references.citation: Science. 2008 Aug 8;321(5890):806-10
references.pmid: 18687957