title: Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line.
abstract: Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner.
authors.affiliation: Molecular Research Lab, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shamileh
authors.initials: S
authors.lastname: Fouladdel
authors.forename: Ali
authors.initials: A
authors.lastname: Khalaj
authors.forename: Neda
authors.initials: N
authors.lastname: Adibpour
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Azizi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001737:Biuret / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001737:Biuret