title: Phosphotyrosine signaling: evolving a new cellular communication system.
abstract: Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. lim@cmp.ucsf.edu
authors.forename: Wendell A
authors.initials: WA
authors.lastname: Lim
authors.forename: Tony
authors.initials: T
authors.lastname: Pawson
mesh_terms: D000818:Animals; D056897:Choanoflagellata / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D019000:Phosphotyrosine / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases
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