title: Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.
abstract: Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and 1D and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 microM, respectively.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Room 539, Chicago, Illinois 60612, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Sturdy
authors.forename: Aleksej
authors.initials: A
authors.lastname: Krunic
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Cho
authors.forename: Scott
authors.initials: S
authors.lastname: Franzblau
authors.forename: Jimmy
authors.initials: J
authors.lastname: Orjala
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002522:Chlorocebus aethiops; D000458:Cyanobacteria / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005618:Fresh Water; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000880:Anthraquinones; D000995:Antitubercular Agents; C552229:eucapsitrione
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