title: Synthesis and antimicrobial studies of thiazolotriazinones.
abstract: A series of 6-substituted phenyl thiazolo-1,2,4-triazinones (8) were obtained by the initial reaction of 6-substituted arylmethyl-3-mercapto-1,2,4-triazin-5-ones (5) with substituted phenacyl bromides (6) and further followed by PPA cyclization. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, Mass and analytical data. Compounds 8a, 8e, 8f and 8h exhibited good antimicrobial activity.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013843:Thiazines; D014227:Triazines