title: The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
abstract: GPR55 is an orphan G protein-coupled receptor that may be engaged by some lipid ligands such as lysophosphatidylinositol and cannabinoid-type compounds. Very little is known about its expression pattern and physio-pathological relevance, and its pharmacology and signaling are still rather controversial. Here we analyzed the expression and function of GPR55 in cancer cells. Our data show that GPR55 expression in human tumors from different origins correlates with their aggressiveness. Moreover, GPR55 promotes cancer cell proliferation, both in cell cultures and in xenografted mice, through the overactivation of the extracellular signal-regulated kinase cascade. These findings reveal the importance of GPR55 in human cancer, and suggest that it could constitute a new biomarker and therapeutic target in oncology.
authors.affiliation: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Andradas
authors.forename: M M
authors.initials: MM
authors.lastname: Caffarel
authors.forename: E
authors.initials: E
authors.lastname: Pérez-Gómez
authors.forename: M
authors.initials: M
authors.lastname: Salazar
authors.forename: M
authors.initials: M
authors.lastname: Lorente
authors.forename: G
authors.initials: G
authors.lastname: Velasco
authors.forename: M
authors.initials: M
authors.lastname: Guzmán
authors.forename: C
authors.initials: C
authors.lastname: Sánchez
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: C524885:GPR55 protein, human; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled; D048049:Extracellular Signal-Regulated MAP Kinases
references.citation: J Soc Gynecol Investig. 2001 Jan-Feb;8(1):1-13
references.pmid: 11223350
references.citation: Brain Res Mol Brain Res. 1999 Feb 5;64(2):193-8
references.pmid: 9931487
references.citation: Br J Pharmacol. 2010 Jun;160(3):762-71
references.pmid: 20590578
references.citation: Nat Rev Cancer. 2007 Feb;7(2):79-94
references.pmid: 17251915
references.citation: Bioorg Med Chem Lett. 2001 Feb 26;11(4):587-90
references.pmid: 11229777
references.citation: Trends Pharmacol Sci. 2009 Mar;30(3):156-63
references.pmid: 19233486
references.citation: Br J Pharmacol. 2010 Feb;159(4):787-96
references.pmid: 20136833
references.citation: Cancer Res. 2006 Jul 1;66(13):6615-21
references.pmid: 16818634
references.citation: J Clin Pathol. 1993 Feb;46(2):189-90
references.pmid: 8459046
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2699-704
references.pmid: 18263732
references.citation: Pain. 2008 Sep 30;139(1):225-236
references.pmid: 18502582
references.citation: FEBS Lett. 2009 Jun 18;583(12):2071-6
references.pmid: 19464294
references.citation: Nat Rev Mol Cell Biol. 2002 Jan;3(1):30-40
references.pmid: 11823796
references.citation: J Biochem. 2010 May;147(5):671-8
references.pmid: 20051382
references.citation: Cancer Cell. 2006 Apr;9(4):287-300
references.pmid: 16616334
references.citation: FASEB J. 2009 Jan;23(1):183-93
references.pmid: 18757503
references.citation: Cancer Res. 2004 Sep 15;64(18):6503-10
references.pmid: 15374961
references.citation: Trends Pharmacol Sci. 2008 Nov;29(11):582-9
references.pmid: 18814923
references.citation: J Cell Sci. 2008 May 15;121(Pt 10):1704-1717
references.pmid: 18445684
references.citation: Vitam Horm. 2009;81:111-37
references.pmid: 19647110
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16511-6
references.pmid: 19805329
references.citation: Br J Pharmacol. 2007 Dec;152(7):1092-101
references.pmid: 17876302
references.citation: Biochem Biophys Res Commun. 2007 Nov 3;362(4):928-34
references.pmid: 17765871
references.citation: Br J Pharmacol. 2010 Jun;160(3):604-14
references.pmid: 20136841
references.citation: J Biol Chem. 2009 Oct 23;284(43):29817-27
references.pmid: 19723626
references.citation: J Biol Chem. 2009 May 1;284(18):12328-38
references.pmid: 19286662
references.citation: Eur J Biochem. 1994 Apr 1;221(1):383-9
references.pmid: 8168525
references.citation: J Biochem. 2009 Jan;145(1):13-20
references.pmid: 18845565
references.citation: Oncogene. 1998 May 7;16(18):2357-65
references.pmid: 9620553
references.citation: Clin Cancer Res. 2006 Nov 15;12(22):6598-602
references.pmid: 17121877
references.citation: Oncogene. 2005 Oct 6;24(44):6626-36
references.pmid: 16103885