Hemorheologic profile in healthy women undergoing controlled ovarian stimulation.
We investigated the hemorheologic profile in 110 women undergoing controlled ovarian stimulation and provide evidence that smokers and women with body mass index>25 kg/m2 exhibit alterations of rheologic profile. A progressive increase of whole-blood viscosity throughout the ovarian stimulation cycle was observed; deformability and aggregation of erythrocytes decreased from baseline to the beginning of recombinant FSH administration, then remained unchanged throughout the next days; hematocrit mildly decreased during the last days of recombinant FSH administration; and fibrinogen and cholesterol levels decreased and increased, respectively, throughout the stimulation cycle.
Fatini
Cinzia
C
Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. cinzia.fatini@unifi.it
Mannini
Lucia
L
Sticchi
Elena
E
Milanini
Maria Novella
MN
Cioni
Gabriele
G
Alessandrello Liotta
Agatina
A
Abbate
Rosanna
R
Noci
Ivo
I
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000009:adverse effects; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000009:adverse effects; D018056:Hemorheology / Q000187:drug effects*; D006728:Hormones / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000628:therapy*; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects; D010062:Ovulation Induction; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D014652:Vascular Diseases / Q000139:chemically induced / Q000453:epidemiology; D055815:Young Adult
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D006728:Hormones; D005640:Follicle Stimulating Hormone; D016729:Leuprolide