title: Clinical characterization and prognostic factors of primary lymphoma of bone in case of Chinese patients.
abstract: Primary lymphoma of bone (PLB) is a very rare neoplasm. Many aspects of this entity have not been well defined or reported in Chinese population. The purpose of our study is to identify the prognostic factors of PLB. Twenty-five patients newly diagnosed with PLB were included in this retrospective study. The main pathologic subtype of PLB was diffuse large B-cell lymphoma (DLBCL), followed by anaplastic large-cell lymphoma. The pelvis was the most commonly involved site (13 cases, 52%). The 5-year overall survival (OS) rate was 55.0%. Cox regression analysis demonstrated that IPI score was an independent prognostic factor of survival (RR = 8.46, P = 0.013). The mean survival time (MST) was 90.3 months for patients with radiation and 54.0 months for those without radiotherapy (P = 0.033). Patients who received the anti-CD20 monoclonal antibody rituximab therapy showed a favorable survival trend, but not significant benefit (MST: 74.5 months vs. 68.6 months, P = 0.149). Some clinical characteristics in the Chinese population are different from those in westerners. The frequency of T-cell subtypes is higher, and the pelvis is the most commonly involved site. Irradiation plus chemotherapy may be better than chemotherapy alone. The role of bisphosphonates and rituximab in PLB therapy warrants further investigation.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Tong-Yu
authors.initials: TY
authors.lastname: Lin
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Li
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Jiang
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Xu
authors.forename: Hui-Qiang
authors.initials: HQ
authors.lastname: Huang
authors.forename: Yue
authors.initials: Y
authors.lastname: Lv
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Sun
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Xia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
references.citation: Ann Oncol. 1997 Aug;8(8):727-37
references.pmid: 9332679
references.citation: Cases J. 2009 Jun 26;2:6384
references.pmid: 19829800
references.citation: Cancer. 1999 Mar 1;85(5):1166-78
references.pmid: 10091803
references.citation: Cancer Treat Rev. 2008;34 Suppl 1:S19-24
references.pmid: 18486348
references.citation: Jpn J Clin Oncol. 2007 Mar;37(3):216-23
references.pmid: 17472971
references.citation: Ann Oncol. 2007 Jan;18(1):129-135
references.pmid: 17018705
references.citation: J Clin Pathol. 2009 Sep;62(9):820-4
references.pmid: 19734480
references.citation: Cancer. 2006 Jun 15;106(12):2652-6
references.pmid: 16700039
references.citation: Int J Oncol. 2006 Jun;28(6):1571-5
references.pmid: 16685458
references.citation: Leuk Lymphoma. 2006 Jan;47(1):65-70
references.pmid: 16321829
references.citation: Aust N Z J Med. 1994 Dec;24(6):701-4
references.pmid: 7717923
references.citation: Ir J Med Sci. 2008 Sep;177(3):247-51
references.pmid: 18516662
references.citation: J Clin Oncol. 2007 Feb 10;25(5):579-86
references.pmid: 17242396
references.citation: Leukemia. 1999 Dec;13(12):2094-8
references.pmid: 10602434
references.citation: Leuk Lymphoma. 2008 Nov;49(11):2125-32
references.pmid: 19021055
references.citation: Eur J Haematol. 2006 Nov;77(5):365-71
references.pmid: 16879606
references.citation: J Cancer Res Clin Oncol. 2005 Mar;131(3):163-8
references.pmid: 15605165
references.citation: Int J Radiat Oncol Biol Phys. 1997 Mar 15;37(5):1087-93
references.pmid: 9169817
references.citation: Leuk Lymphoma. 2010 Jan;51(1):39-49
references.pmid: 19860629