A thermodynamic model of bone remodelling: the influence of dynamic loading together with biochemical control.
Understanding of the bone remodelling process has considerably increased during the last 20 years. Since the ability to simulate (and predict) the effects of bone remodelling offers substantial insights, several models have been proposed to describe this phenomenon. The strength of the presented model is that it includes biochemical control factors (e.g., the necessity of cell-to-cell contact, which is mediated by the RANKL-RANK-OPG chain during osteoclastogenesis) and mechanical stimulation, the governing equations are derived from interaction kinetics (e.g., mass is preserved in running reactions), and the parameters are measurable. Behaviour of the model is in accordance with experimental and clinical observations, such as the role of dynamic loading, the inhibitory effect of dynamic loading on osteoclastogenesis, the observation that polykaryon osteoclasts are activated and formed by a direct cell-to-cell contact, and the correct concentrations of osteoblasts, osteoclasts, and osteocytes. The model does not yet describe the bone remodelling process in complete detail, but the implemented simplifications describe the key features and further details of control mechanisms may be added.
Klika
V
V
Institute of Thermomechanics, v.v.i., Academy of Sciences of Czech Republic, 182 00 Prague, Czech Republic. klika@it.cas.cz
Marsik
F
F
D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D053244:Osteoprotegerin / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013314:Stress, Mechanical; D013816:Thermodynamics; D016474:Weight-Bearing / Q000502:physiology
D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human