Current perspectives of natural killer cell education by MHC class I molecules.
From the early days of natural killer (NK) cell research, it was clear that MHC genes controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject transplanted allogeneic bone marrow and to kill tumour cells. Although several mechanisms that are involved in this 'education' process have been clarified, most of the mechanisms have still to be identified. Here, we review the current understanding of the processes that are involved in NK cell education, including how the host MHC class I molecules regulate responsiveness and receptor repertoire formation in NK cells and the signalling pathways that are involved.
Höglund
Petter
P
Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Brodin
Petter
P
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D015395:Histocompatibility Antigens Class I
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