title: The role of serotonin in respiratory function and dysfunction.
abstract: Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.
authors.affiliation: Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2 M), Unité Mixte de Recherche 6231, CNRS-Université Aix-Marseille II & III, Faculté Saint Jérôme, Marseille, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Hilaire
authors.forename: Nicolas
authors.initials: N
authors.lastname: Voituron
authors.forename: Clément
authors.initials: C
authors.lastname: Menuet
authors.forename: Ronaldo M
authors.initials: RM
authors.lastname: Ichiyama
authors.forename: Hari H
authors.initials: HH
authors.lastname: Subramanian
authors.forename: Mathias
authors.initials: M
authors.lastname: Dutschmann
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002658:Developmental Disabilities / Q000150:complications / Q000378:metabolism; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012119:Respiration; D012120:Respiration Disorders / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012701:Serotonin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin
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