Herpes simplex virus type 1/adeno-associated virus hybrid vectors.
Herpes simplex virus type 1 (HSV-1) amplicons can accommodate foreign DNA of any size up to 150 kbp and, therefore, allow extensive combinations of genetic elements. Genomic sequences as well as cDNA, large transcriptional regulatory sequences for cell type-specific expression, multiple transgenes, and genetic elements from other viruses to create hybrid vectors may be inserted in a modular fashion. Hybrid amplicons use genetic elements from HSV-1 that allow replication and packaging of the vector DNA into HSV-1 virions, and genetic elements from other viruses that either direct integration of transgene sequences into the host genome or allow episomal maintenance of the vector. Thus, the advantages of the HSV-1 amplicon system, including large transgene capacity, broad host range, strong nuclear localization, and availability of helper virus-free packaging systems are retained and combined with those of heterologous viral elements that confer genetic stability to the vector DNA. Adeno-associated virus (AAV) has the unique capability of integrating its genome into a specific site, designated AAVS1, on human chromosome 19. The AAV rep gene and the inverted terminal repeats (ITRs) that flank the AAV genome are sufficient for this process. HSV-1 amplicons have thus been designed that contain the rep gene and a transgene cassette flanked by AAV ITRs. These HSV/AAV hybrid vectors direct site-specific integration of transgene sequences into AAVS1 and support long-term transgene expression.
de Oliveira
Anna Paula
AP
Institute of Virology, University of Zurich, Zurich, Switzerland.
Fraefel
Cornel
C
J Virol. 1997 Oct;71(10):7750-7
9311860
J Virol. 1996 Oct;70(10):7190-7
8794366
J Virol. 2004 Oct;78(20):10977-86
15452218
J Virol. 2006 Apr;80(7):3293-300
16537596
J Virol. 2005 Jul;79(14):8847-60
15994778
J Virol. 1977 Aug;23(2):394-411
196115
J Virol. 1998 Jul;72(7):6195-8
9621089
J Virol. 2006 Jun;80(11):5241-50
16699004
Nat Med. 1997 Dec;3(12):1354-61
9396605
J Virol. 1994 May;68(5):2947-57
8151765
J Virol. 2002 Jul;76(14):7163-73
12072516
Curr Opin Mol Ther. 2004 Oct;6(5):482-90
15537049
Brain Res. 1996 Mar 25;713(1-2):99-107
8724980
Gene Ther. 2002 Nov;9(21):1447-54
12378407
J Virol. 2006 Mar;80(5):2358-68
16474142
J Virol. 1997 Nov;71(11):8780-9
9343238
J Virol. 1997 Sep;71(9):6850-62
9261410
J Virol. 2002 Aug;76(16):8446-54
12134047
J Gen Virol. 1992 Oct;73 ( Pt 10):2709-13
1328483
J Virol. 2006 Jul;80(13):6286-94
16775316
Mol Ther. 2006 Mar;13(3):463-83
16412695
J Virol. 2009 Jan;83(2):1009-17
18987147
J Virol. 1998 Apr;72(4):2777-87
9525597
Nucleic Acids Res. 2007;35(15):e98
17675302
J Virol. 1999 May;73(5):3994-4003
10196295
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11307-12
8876131
J Virol. 2001 Oct;75(20):9991-4
11559833
Nucleic Acids Res. 1999 Apr 1;27(7):1674-82
10075999
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1467-74
5227666
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2091-2
19211802
Nat Med. 1997 Sep;3(9):964-9
9288721
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7871-6
12796511
Hum Gene Ther. 1997 Feb 10;8(3):359-70
9048203
Virology. 2000 Sep 15;275(1):1-8
11017782
J Virol. 1997 Mar;71(3):1897-905
9032320
J Cell Biol. 1997 Mar 10;136(5):1007-21
9060466
J Virol. 2001 Feb;75(4):1928-40
11160692
Hum Gene Ther. 1995 Dec;6(12):1531-41
8664378
J Virol. 2001 Jan;75(2):821-33
11134295
J Virol. 1996 Jul;70(7):4495-501
8676474
Science. 1993 May 14;260(5110):926-32
8493530
Expert Opin Biol Ther. 2007 Jul;7(7):975-95
17665988
J Virol. 1996 Apr;70(4):2449-59
8642650
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5453-8
18378902
Hum Gene Ther. 1998 May 20;9(8):1181-6
9625257
Gene Ther. 2008 Jun;15(11):817-22
18401436
J Virol. 1999 Mar;73(3):2517-26
9971837
J Virol. 2005 Sep;79(17):11082-94
16103159
Hum Gene Ther. 2004 Jan;15(1):47-61
14965377
Proc Natl Acad Sci U S A. 1985 Feb;82(3):694-8
2983310
J Virol. 1995 Dec;69(12):7472-82
7494253
Virology. 1985 Nov;147(1):217-22
2998066
Clin Microbiol Rev. 2008 Oct;21(4):583-93
18854481
Gene Ther. 2001 Jun;8(11):864-73
11423934
Nat Med. 1999 Jan;5(1):78-82
9883843
J Virol. 1997 Feb;71(2):1079-88
8995628
Hum Gene Ther. 2002 Jan 20;13(2):261-73
11812282
J Virol. 2000 Oct;74(20):9441-50
11000213
J Gene Med. 2000 Nov-Dec;2(6):395-408
11199260
Virology. 1993 Nov;197(1):459-62
8212585
J Virol. 2005 Sep;79(18):11990-2001
16140775
J Virol. 1990 Jun;64(6):3012-8
2159559
J Virol. 1995 Apr;69(4):2038-46
7884849
Lancet. 2007 Jun 23;369(9579):2097-105
17586305
Gene Ther. 2004 May;11(10):829-37
14985784
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3428-32
10688913
Biotechniques. 2001 Aug;31(2):394-402, 404-5
11515376
J Virol. 1998 Feb;72(2):1438-45
9445046
J Virol. 1995 Nov;69(11):6917-24
7474109
Hum Gene Ther. 1995 Oct;6(10):1329-41
8590738
J Virol. 2006 Jan;80(1):38-50
16352529
J Virol. 2005 Oct;79(19):12218-30
16160148
J Med Virol. 1999 Nov;59(3):406-11
10502275
J Virol. 1999 Nov;73(11):9515-20
10516060
J Virol. 2003 May;77(9):5324-32
12692234
J Virol. 1998 Jan;72(1):309-19
9420229
Gene Ther. 2007 Aug;14(15):1143-51
17495946
J Virol. 1986 May;58(2):513-21
3009865
J Virol. 1981 Jan;37(1):191-206
6260973
J Virol. 2001 Nov;75(21):10250-8
11581393
J Virol. 2005 Sep;79(18):11776-87
16140755
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7966-72
8755586
Curr Gene Ther. 2007 Oct;7(5):347-60
17979681
Mol Med. 1997 Dec;3(12):813-25
9440115
J Virol. 1979 Feb;29(2):448-57
219240
Contrib Microbiol. 2000;4:68-84
10941571
J Virol. 1999 Dec;73(12):10426-39
10559361
J Virol. 1996 Dec;70(12):8422-30
8970963
J Virol. 1996 May;70(5):3227-34
8627803
Mol Ther. 2004 Aug;10(2):302-17
15294177
Virology. 1995 Jun 1;209(2):692-5
7778304
Annu Rev Genet. 2004;38:819-45
15568995
Gene Ther. 2005 Jun;12(11):873-80
15829993
J Virol. 2000 May;74(9):3953-66
10756007
J Virol. 2005 Jan;79(2):1071-83
15613336
J Virol. 2005 Dec;79(23):14516-25
16282451
J Virol. 2004 Aug;78(16):8917-21
15280500
Mol Biol Cell. 2002 Aug;13(8):2795-809
12181347
J Cell Sci. 2006 Jan 1;119(Pt 1):23-30
16339172
Exp Neurol. 1998 Apr;150(2):183-94
9527887
Gene Ther. 1997 Oct;4(10):1120-5
9415320
Hum Gene Ther. 2003 May 1;14(7):611-26
12804144
Gene Ther. 2001 May;8(9):704-12
11406765
Pharm Res. 2008 Mar;25(3):489-99
17763830
EMBO J. 1991 Dec;10(12):3941-50
1657596
Science. 1992 Jun 12;256(5063):1550-2
1317968
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12381-5
12221283
Mol Ther. 2005 Nov;12(5):803-12
16112910
J Virol. 2002 Jul;76(14):7150-62
12072515
Hum Gene Ther. 2002 Jul 20;13(11):1391-412
12162821
Mol Ther. 2002 Jul;6(1):12-8
12095298
Cancer Res. 2004 Jan 1;64(1):273-8
14729634
J Virol. 2003 Feb;77(3):1904-15
12525625
J Gene Med. 2004 Feb;6 Suppl 1:S212-22
14978764
J Virol. 2008 Apr;82(7):3311-9
18216103
Hum Gene Ther. 2007 Feb;18(2):171-82
17328683
Front Biosci. 2008 Jan 01;13:2653-9
17981740
Hum Gene Ther. 1999 Apr 10;10(6):1031-9
10223736
Nat Med. 1999 Jan;5(1):71-7
9883842
J Virol. 1994 Mar;68(3):2011-5
8107263
J Virol. 2002 May;76(10):4785-91
11967295
Mol Ther. 2008 Jan;16(1):81-8
17998902
J Virol. 1988 Mar;62(3):912-21
2828686
J Virol. 1990 Dec;64(12):6070-9
2173780
Curr Gene Ther. 2004 Dec;4(4):409-16
15578990
J Virol. 2007 May;81(9):4732-43
17314170
J Cell Biol. 2006 Sep 25;174(7):1009-21
17000878
Biochem Soc Trans. 2004 Nov;32(Pt 5):697-701
15493991
J Virol. 1997 Oct;71(10):7951-9
9311886
J Virol. 1996 Jul;70(7):4311-6
8676453
Gene Ther. 2003 Sep;10(19):1691-702
12923568
J Virol. 1986 Mar;57(3):933-41
3005637
Micron. 2002;33(4):327-37
11814872
Nat Biotechnol. 2001 Nov;19(11):1067-70
11689853
Hum Gene Ther. 2001 Jan 20;12(2):161-7
11177553
Mol Ther. 2000 Oct;2(4):394-403
11020356
Curr Top Microbiol Immunol. 1996;218:1-23
8794242
Biotechnol Prog. 2005 Jan-Feb;21(1):154-60
15903253
Mol Ther. 2001 Oct;4(4):289-96
11592830
Mol Cell Biol. 2000 Jul;20(13):4922-31
10848617
EMBO J. 1992 Dec;11(13):5071-8
1334463
J Neurochem. 1997 May;68(5):1792-803
9109503
J Virol Methods. 2001 Aug;96(2):97-105
11445141
Virology. 1984 Apr 15;134(1):52-63
6324476
Gene Ther. 1999 Jun;6(6):986-93
10455400
J Virol. 2009 Feb;83(4):1660-8
19073727
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13525-30
11707592
J Virol. 2000 Mar;74(6):2777-85
10684294
Oral Dis. 1997 May;3 Suppl 1:S177-9
9456684
J Virol. 1997 Jul;71(7):5432-40
9188615
J Virol. 2006 Jan;80(1):505-13
16352574
J Clin Invest. 2001 Aug;108(4):503-10
11518721
Mol Ther. 2006 Apr;13(4):671-82
16442847
Hum Gene Ther. 2005 Apr;16(4):408-16
15871672
Hum Gene Ther. 2005 Jul;16(7):781-91
16000060
EMBO Rep. 2006 Sep;7(9):911-8
16906131
J Neurochem. 2009 May;109(3):838-45
19250335
Rev Med Virol. 2007 Sep-Oct;17(5):313-26
17573668
Cell. 1982 Aug;30(1):295-304
6290080
Mol Ther. 2007 Apr;15(4):649-50
17372595
Virus Res. 2009 Aug;143(2):222-34
19651457
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11288-94
8876128
J Virol. 1993 Dec;67(12):7373-82
7901428
J Virol. 2002 Jun;76(11):5411-21
11991970
Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8979-83
8090756
Mol Ther. 2008 Oct;16(10):1648-56
18682697
J Virol. 1987 Jul;61(7):2198-207
3035220
J Virol. 2005 Jan;79(1):193-201
15596815
PLoS Pathog. 2009 Mar;5(3):e1000340
19282980
Hear Res. 1999 Aug;134(1-2):1-8
10452370
Mol Ther. 2003 May;7(5 Pt 1):604-12
12718903
Gene Ther. 2007 Jul;14(14):1078-91
17460718
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10039-43
7937833
Hum Gene Ther. 2000 Nov 20;11(17):2389-401
11096443
Methods. 2002 Oct;28(2):158-67
12413414
Curr Gene Ther. 2005 Jun;5(3):285-97
15975006
PLoS Pathog. 2009 Mar;5(3):e1000352
19325890
Hum Gene Ther. 2001 Oct 10;12(15):1867-79
11589829
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2211-5
2156265
J Gene Med. 2006 Sep;8(9):1131-40
16810631
Hum Gene Ther. 1998 Dec 10;9(18):2745-60
9874273
J Invest Dermatol. 1997 May;108(5):803-8
9129236
Gene Ther. 1995 Aug;2(6):429-32
7584119
J Virol. 1991 May;65(5):2476-83
1850024
Virology. 1986 Jul 15;152(1):110-7
3012864
J Virol. 2004 Feb;78(3):1540-51
14722308
Virology. 2000 Jul 5;272(2):338-46
10873777
J Neurosci Res. 1990 Nov;27(3):427-39
2129047
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5808-12
8016070
Mol Ther. 2006 Mar;13(3):580-8
16412694
Mol Cell. 2007 May 25;26(4):479-89
17531807
J Virol. 2005 Oct;79(20):13047-59
16189007
Hum Gene Ther. 1999 Sep 20;10(14):2325-35
10515452
J Neurosurg. 1993 Jul;79(1):104-10
8391069
J Virol. 1989 Mar;63(3):1023-30
2536816
J Gen Virol. 1988 Jun;69 ( Pt 6):1147-56
2838568
J Virol. 2006 Dec;80(24):12312-23
17035316
Nucleic Acids Res. 2003 Nov 1;31(21):6206-13
14576307
J Virol. 2008 May;82(10):4974-90
18337577
J Virol. 2006 Aug;80(16):8211-24
16873277
Mol Ther. 2006 Sep;14(3):316-27
16824801
J Virol. 1990 Apr;64(4):1630-8
2157048
J Virol. 2002 Jan;76(2):791-801
11752169
J Virol. 2006 Nov;80(22):10919-30
16943285
J Virol. 2000 Feb;74(3):1524-32
10627564
J Virol Methods. 2005 Jan;123(1):65-72
15582700
Gene Ther. 2003 Aug;10(17):1528-34
12900769
J Virol. 1999 Dec;73(12):10010-9
10559315
Infect Immun. 1970 Dec;2(6):716-22
16557905
J Virol. 2002 Dec;76(24):12792-802
12438604
Eur J Neurosci. 2003 Jul;18(2):403-11
12887422
J Virol. 1998 Apr;72(4):3330-9
9525660
J Virol. 1997 Sep;71(9):6555-9
9261376
J Virol. 1974 Jul;14(1):8-19
4365321
J Virol Methods. 2004 Nov;121(2):209-15
15381358
Mol Ther. 2008 Sep;16(9):1525-38
18628754
Hum Gene Ther. 1997 Apr 10;8(6):747-54
9113514
Cell. 2004 Jan 23;116(2):281-97
14744438
Gene Ther. 1997 Nov;4(11):1132-41
9425435
J Virol. 2001 Jun;75(12):5697-702
11356979
EMBO J. 1982;1(7):863-7
6329712
J Virol. 2006 Mar;80(5):2118-26
16474120
Hum Gene Ther. 2005 May;16(5):541-50
15916479
Hum Gene Ther. 1999 Jan 20;10(2):201-13
10022545
Hum Gene Ther. 2003 Jul 20;14(11):1049-63
12885345
Cancer Res. 1988 Jun 1;48(11):3123-9
2835153
Virus Res. 2006 May;117(2):202-8
16417939
J Virol. 1991 Mar;65(3):1066-81
1847436
J Virol. 2004 Jan;78(1):441-53
14671124
Virology. 1977 Jun 15;79(2):292-301
194407
Biotechniques. 2005 Sep;39(3):381-91
16206910
J Virol. 2006 Feb;80(4):1874-85
16439543
J Virol. 2006 Feb;80(4):1672-9
16439524
J Gen Virol. 2000 Jan;81(Pt 1):1-19
10640537
Gene Ther. 1996 Dec;3(12):1124-32
8986439
Virology. 1964 Feb;22:262-9
14165331
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11335-9
18682563
J Mol Biol. 2006 Apr 21;358(1):38-45
16516232
J Virol. 1981 Oct;40(1):241-7
6270377
Hum Gene Ther. 2002 Jul 1;13(10):1235-43
12133276
Nature. 2008 Aug 7;454(7205):780-3
18596690
J Biol Chem. 2006 Mar 17;281(11):7110-7
16407234
J Virol. 2004 Jun;78(12):6344-59
15163728
J Virol. 2001 Feb;75(3):1236-51
11152497
Hum Gene Ther. 2003 Jun 10;14(9):897-906
12828860
Curr Gene Ther. 2004 Dec;4(4):385-408
15578989