Image-guided radiofrequency ablation for the treatment of early-stage non-small cell lung neoplasm in high-risk patients.
Lung cancer is the most common cause of cancer-related mortality in the United States. Surgical resection with a lobectomy is the standard treatment for stage I non-small cell lung cancer. With an aging population, however, there are a significant number of patients who have other comorbidities that preclude surgical resection. Image-guided radiofrequency ablation is a new emerging modality of treatment which may be applicable in this high-risk group of patients. In this article, we review the principles of radiofrequency ablation, the common devices in use, the results of ablate and resect studies, future directions, and the results of treatment for stage I non-small cell lung neoplasm.
Pennathur
Arjun
A
The Heart, Lung, and Esophageal Surgery Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. apennathur@aol.com
Abbas
Ghulam
G
Schuchert
Matthew J
MJ
Landreneau
Rodney J
RJ
Luketich
James D
JD
D000367:Age Factors; D000375:Aging; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D015897:Comorbidity; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D019060:Minimally Invasive Surgical Procedures; D010414:Pennsylvania; D011013:Pneumonectomy / Q000295:instrumentation / Q000379:methods; D011856:Radiographic Image Enhancement / Q000295:instrumentation / Q000379:methods; D018570:Risk Assessment; D016896:Treatment Outcome
J Thorac Cardiovasc Surg. 2009 Jan;137(1):160-6
19154919
Anticancer Res. 2004 Jan-Feb;24(1):339-43
15015618
Ann Surg Oncol. 2007 Aug;14(8):2400-5
17505859
J Thorac Cardiovasc Surg. 2003 Apr;125(4):929-37
12698158
Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):149-54
9422571
Chest. 2005 Nov;128(5):3507-11
16304306
J Thorac Cardiovasc Surg. 2007 Nov;134(5):1306-12
17976467
Radiographics. 2005 Oct;25 Suppl 1:S69-83
16227498
Radiology. 2007 Apr;243(1):268-75
17392258
Expert Rev Med Devices. 2008 Sep;5(5):613-21
18803472
Lancet Oncol. 2008 Jul;9(7):621-8
18565793
Ann Thorac Surg. 2009 Nov;88(5):1601-6; discussion 1607-8
19853119
Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):119-130
12182981
Ann Thorac Surg. 2009 Apr;87(4):1030-6; discussion 1036-9
19324124
Ann Thorac Surg. 2010 Jan;89(1):265-8
20103250
Ann Surg Oncol. 2004 Feb;11(2):207-12
14761926
Ann Thorac Surg. 1995 Sep;60(3):615-22; discussion 622-3
7677489
Radiology. 2004 Jan;230(1):125-34
14645875
J Thorac Cardiovasc Surg. 2006 May;131(5):1002-6
16678582
J Thorac Cardiovasc Surg. 2007 Oct;134(4):857-64
17903496
J Thorac Cardiovasc Surg. 1997 Apr;113(4):691-8; discussion 698-700
9104978
Eur J Cardiothorac Surg. 2006 Jul;30(1):177-83
16723242
Radiology. 2010 Jan;254(1):301-7
20032160
Ann Thorac Surg. 2006 Jul;82(1):365-71
16798261
J Thorac Cardiovasc Surg. 2005 Mar;129(3):639-44
15746749
Semin Thorac Cardiovasc Surg. 2008 Winter;20(4):279-84
19251165
Eur Radiol. 2003 Nov;13(11):2540-7
12707797
Int J Radiat Oncol Biol Phys. 1993 Oct 20;27(3):517-23
8226143
Chest. 2010 Apr;137(4):890-7
19858232
Int J Radiat Oncol Biol Phys. 1983 Mar;9(3):373-82
6841190