Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study.
OBJECTIVE
The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women.


METHODS
Eighty postmenopausal women affected by the metabolic syndrome were enrolled prospectively in the study and treated with diet plus supplementation of myo-inositol (2 g BID plus diet: intervention group) or with diet plus placebo (control group) for 6 months. They were evaluated at baseline and after 6 months for insulin resistance (homeostasis model assessment ratio [HOMA] insulin resistance), lipid profile, and blood pressure.


RESULTS
Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. In the group treated with myo-inositol, a decrease in diastolic blood pressure (-11%), HOMA index (-75%), and serum triglycerides (-20%) and an improvement in high-density lipoprotein cholesterol (22%) were shown.


CONCLUSIONS
Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women.
Giordano
Domenico
D
Policlinico Hospital, Reggio di Calabria, Italy.
Corrado
Francesco
F
Santamaria
Angelo
A
Quattrone
Simona
S
Pintaudi
Basilio
B
Di Benedetto
Antonino
A
D'Anna
Rosario
R
D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007294:Inositol / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000188:drug therapy*; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D007294:Inositol