title: The Role of Adipokines in Understanding the Associations between Obesity and Depression.
abstract: Objective. Two major causes of disability, major depression and obesity, share overlapping psychosocial and pathophysiological etiologies. Studies are now focused on biological mechanisms linking the two illnesses, and there is interest in the role that adipokines may have in mediating the association between obesity and depression. We reviewed the literature to look at what is currently known about this association, focusing on the adipokines leptin, adiponectin, and resistin. Methods. A MEDLINE search, citing articles from 1966 onward, supplemented by a review of bibliographies, was conducted to identify relevant studies. Results. This paper identified plausible pathways underlying a link between adipokines and depression. Only a few studies have yet been conducted specifically examining these biomarkers in patients with depression, but the results are intriguing. Conclusion. This paper is one of the first to examine the association between adipokines and depression. It provides an overview of the physiological role of adipokines and summarizes the data suggesting that they may be dysregulated in major depression. This area of research may become increasingly important as new treatment strategies are developed.
authors.affiliation: Mood Disorders Program, Centre for Mountain Health Services, McMaster University, D150-A, 100 West 5th Street, St. Joseph's Healthcare, Hamilton, ON, Canada L8N 3K7.
authors.forename: Valerie H
authors.initials: VH
authors.lastname: Taylor
authors.forename: Glenda M
authors.initials: GM
authors.lastname: Macqueen
references.citation: J Diabetes Complications. 2003 Mar-Apr;17(2):108-13
references.pmid: 12614978
references.citation: Proc Nutr Soc. 2002 Nov;61(4):473-87
references.pmid: 12691177
references.citation: J Clin Psychiatry. 2009 Aug;70(8):1078-90
references.pmid: 19497250
references.citation: Psychosom Med. 2005 May-Jun;67 Suppl 1:S26-8
references.pmid: 15953796
references.citation: CNS Drugs. 2001;15(5):361-73
references.pmid: 11475942
references.citation: Curr Opin Pharmacol. 2007 Dec;7(6):648-52
references.pmid: 18032111
references.citation: Pharmacol Biochem Behav. 2006 Oct;85(2):474-9
references.pmid: 17126386
references.citation: Psychiatry Res. 2002 Dec 30;113(3):255-68
references.pmid: 12559482
references.citation: Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
references.pmid: 10092513
references.citation: Trends Endocrinol Metab. 2002 Mar;13(2):84-9
references.pmid: 11854024
references.citation: Eur J Endocrinol. 2004 Mar;150(3):339-44
references.pmid: 15012619
references.citation: Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33
references.pmid: 12736161
references.citation: FEBS Lett. 2005 Sep 26;579(23):5163-9
references.pmid: 16140297
references.citation: J Clin Psychiatry. 2010 Aug;71(8):1007-16
references.pmid: 20156411
references.citation: N Engl J Med. 1991 Aug 29;325(9):606-12
references.pmid: 1713648
references.citation: J Comp Neurol. 1998 Jun 15;395(4):535-47
references.pmid: 9619505
references.citation: J Clin Endocrinol Metab. 2003 Jun;88(6):2714-8
references.pmid: 12788878
references.citation: J Affect Disord. 1988 May-Jun;14(3):213-22
references.pmid: 2838538
references.citation: Br J Psychiatry. 1991 Jan;158:59-63
references.pmid: 1673078
references.citation: Dig Dis Sci. 2009 Sep;54(9):1847-56
references.pmid: 19052866
references.citation: Biochem Biophys Res Commun. 2002 Jan 25;290(3):1084-9
references.pmid: 11798186
references.citation: Psychosom Med. 2001 Mar-Apr;63(2):267-72
references.pmid: 11292274
references.citation: PLoS One. 2008 Jan 02;3(1):e1392
references.pmid: 18167551
references.citation: Nature. 2001 Jan 18;409(6818):292-3
references.pmid: 11201721
references.citation: Clin Sci (Lond). 2005 Sep;109(3):243-56
references.pmid: 16104844
references.citation: Ann N Y Acad Sci. 2010 Apr;1193:160-3
references.pmid: 20398023
references.citation: J Hepatol. 2006 Mar;44(3):537-43
references.pmid: 16310276
references.citation: Physiol Res. 2003;52(1):61-6
references.pmid: 12625808
references.citation: Neuroendocrinology. 2001 Apr;73(4):243-7
references.pmid: 11340338
references.citation: Neurosci Lett. 2006 Oct 30;407(3):211-3
references.pmid: 16973279
references.citation: Eur J Endocrinol. 2002 Nov;147(5):571-4
references.pmid: 12444887
references.citation: Nat Rev Cancer. 2004 Aug;4(8):579-91
references.pmid: 15286738
references.citation: Eur J Pharmacol. 2004 Jun 16;493(1-3):41-4
references.pmid: 15189762
references.citation: Med Hypotheses. 2008;70(4):902-3
references.pmid: 17920209
references.citation: Nat Neurosci. 2005 May;8(5):566-70
references.pmid: 15856064
references.citation: J Biol Chem. 2001 Jul 13;276(28):25651-3
references.pmid: 11373275
references.citation: Diabetes Obes Metab. 2004 May;6(3):163-70
references.pmid: 15056123
references.citation: Horm Metab Res. 1996 Dec;28(12):714-7
references.pmid: 9013749
references.citation: Int J Obes (Lond). 2006 Jan;30(1):6-13
references.pmid: 16344843
references.citation: Ann Intern Med. 2001 Aug 21;135(4):306-7
references.pmid: 11511160
references.citation: Acta Psychiatr Scand Suppl. 2007;(433):58-71
references.pmid: 17280572
references.citation: Mediators Inflamm. 2010;2010:573594
references.pmid: 20490354
references.citation: Br J Nutr. 2004 Sep;92(3):347-55
references.pmid: 15469638
references.citation: Int J Obes Relat Metab Disord. 2003 Aug;27(8):875-88
references.pmid: 12861227
references.citation: Mol Cell Endocrinol. 2010 Mar 25;316(2):154-64
references.pmid: 19804814
references.citation: Biochem Biophys Res Commun. 2001 Dec 21;289(5):1328-33
references.pmid: 11741341
references.citation: Obes Res. 2002 Nov;10(11):1095-103
references.pmid: 12429872
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1159-62
references.pmid: 16678955
references.citation: J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):414-9
references.pmid: 18426966
references.citation: Mol Psychiatry. 2006 Oct;11(10):892-902
references.pmid: 16880826
references.citation: J Clin Invest. 2005 May;115(5):1111-9
references.pmid: 15864338
references.citation: EMBO J. 2000 Aug 1;19(15):4046-55
references.pmid: 10921885
references.citation: J Clin Invest. 2000 Jun;105(12):1827-32
references.pmid: 10862798
references.citation: Biochem Biophys Res Commun. 2003 Feb 21;301(4):1045-50
references.pmid: 12589818
references.citation: Brain Behav Immun. 2003 Aug;17(4):276-85
references.pmid: 12831830
references.citation: Forum Nutr. 2010;63:123-132
references.pmid: 19955780
references.citation: J Psychiatr Res. 1998 Nov-Dec;32(6):403-10
references.pmid: 9844957
references.citation: Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1593-8
references.pmid: 16423896
references.citation: J Psychiatr Res. 2007 Apr-Jun;41(3-4):344-50
references.pmid: 16497334
references.citation: Curr Diab Rep. 2003 Aug;3(4):293-8
references.pmid: 12866991
references.citation: BMJ. 1998 Dec 12;317(7173):1608-9
references.pmid: 9848897
references.citation: N Engl J Med. 2001 Nov 1;345(18):1345-6
references.pmid: 11794158
references.citation: Mol Cell Endocrinol. 2010 Mar 25;316(2):129-39
references.pmid: 19723556
references.citation: Ann N Y Acad Sci. 2004 Dec;1032:1-7
references.pmid: 15677391
references.citation: Expert Opin Ther Targets. 2005 Apr;9(2):245-51
references.pmid: 15934913
references.citation: J Affect Disord. 2006 Jan;90(1):21-7
references.pmid: 16324751
references.citation: Curr Opin Lipidol. 2003 Dec;14(6):561-6
references.pmid: 14624132
references.citation: Endocrinology. 2004 Dec;145(12):5589-97
references.pmid: 15319349
references.citation: Nature. 2001 Jan 18;409(6818):307-12
references.pmid: 11201732
references.citation: J Clin Invest. 2003 Jan;111(2):225-30
references.pmid: 12531878