Direct MRI detection of the neuronal magnetic field: the effect of the dendrite branch.
In recent years, neuronal current MRI (nc-MRI) was proposed as a new imaging method to directly map the magnetic field change caused by neuronal activity. Nc-MRI could offer improved spatial and temporal resolution compared to blood hemodynamics-based functional magnetic resonance imaging (fMRI). In this paper, with a finite current dipole as the model of dendrite or dendrite branch, we investigated the spatial distribution of the magnetic field generated by synchronously activated neurons to evaluate the possibility of nc-MRI. Our simulations imply that the existence of a dendrite branch may not only increase the strength of the neuronal magnetic field (NMF), but also raise the non-uniform and unsymmetry of the NMF; therefore, it can enhance the detectability of the neuronal current magnetic field by MRI directly. The results show that the signal phase shift is enlarged, but it is unstable and is still very small, <<1 radian, while the magnitude signal may be strong enough for a typical MRI voxel to be detected. We suggest making further efforts to measure the magnitude signal which may induce a large effect in an nc-MRI experiment.
Huang
Ying-Ling
YL
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, People's Republic of China.
Xiong
Hong-Chuan
HC
Yao
De-Zhong
DZ
D000328:Adult; D003712:Dendrites / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008954:Models, Biological