Association study of interferon-γ, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease.
OBJECTIVE
The increased production of proinflammatory mediators such as cytokines and prostaglandins may interact at multiple levels with neurodegeneration in Alzheimer disease (AD). This study was undertaken to evaluate the possible role of interferon-γ (IFN-γ) T+874A, cytoplasmic phospholipase A₂ (cPLA2) BanI, and cyclooxygenase-2 (COX-2) G-765C polymorphisms in AD.


METHODS
The study included 237 probable patients with AD who met the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-AD and Related Disorders Association, and 245 probands in the healthy comparison (HC) group.


RESULTS
No significant difference in mean age or in the distribution of genders between AD and HC groups was found. The COX-2 G/G genotype was significantly more frequent in the AD, when compared with the HC group. There was no significant correlation between IFN-γ or cPLA2 genotypes and AD.


CONCLUSIONS
Our findings indicate that the COX-2 G/G genotype is associated with AD and support the involvement of COX-2 in AD etiology.
Fehér
Agnes
A
Department of Psychiatry, University of Szeged, Hungary. fehera@nepsy.szote.u-szeged.hu
Juhász
Anna
A
Rimanóczy
Agnes
A
Kálmán
János
J
Janka
Zoltán
Z
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015577:Geriatric Assessment; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D054510:Phospholipases A2, Cytosolic / Q000235:genetics*; D011110:Polymorphism, Genetic
D007371:Interferon-gamma; D051546:Cyclooxygenase 2; D054510:Phospholipases A2, Cytosolic