Association of apolipoprotein E polymorphisms with temporal lobe epilepsy in a Chinese Han population.
Apolipoprotein E (ApoE) has been implicated as one of the susceptibility genes for temporal lobe epilepsy (TLE). Previous studies indicate that ApoE ɛ4 is associated with several disease-related traits including the increased risk of late posttraumatic seizures, earlier onset of TLE, refractory complex partial seizures, and postictal confusion. Contradictory data were also reported regarding the association between ApoE polymorphisms and TLE. The present study was designed to investigate whether ApoE ɛ4 is a risk factor for TLE and the above clinical variables, as well as to determine whether -491A/T polymorphism may independently alter the risk for TLE in a Chinese Han population. The ApoE and -491A/T polymorphisms were genotyped in 558 controls and 735 patients including 560 TLE patients using polymerase chain reaction-restriction fragment length polymorphism. A significant association was detected between prior trauma and the ApoE ɛ4 allele in TLE patients. However, no significant differences were observed in the genotype and haplotype distributions and allele frequencies of these two polymorphisms between cases and controls. Furthermore, there were no significant associations between these two polymorphisms and the other clinical variables examined. The study illustrates that the ApoE ɛ4 allele may be involved in the development of TLE in those patients with prior trauma in the Chinese Han population.
Fu
Yuan-Hui
YH
College of Life Sciences & Bioengineering, Beijing Jiaotong University, 3 Shangyuan Residence, Haidian District, Beijing 100044, PR China.
Lv
Rui-Juan
RJ
Jin
Li-Ri
LR
Lu
Qiang
Q
Shao
Xiao-Qiu
XQ
He
Jin-Sheng
JS
Wu
Li-Wen
LW
Zhang
Li-Shu
LS
Hu
Hong-Gang
HG
D000328:Adult; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D001930:Brain Injuries / Q000150:complications / Q000235:genetics; D015331:Cohort Studies; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D055815:Young Adult
D053327:Apolipoprotein E4; D001057:Apolipoproteins E