title: Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant.
abstract: Splenic rupture (SR) is a rare adverse event observed in patients treated with G-CSF as a peripheral hematopoietic stem cell (PHSC) mobilizing agent, mostly in myeloma multiple and amiloidosis; to date, to our knowledge, it has not been previously described in plasma-cell leukemia (PCL). We report a case of a woman with PCL, who presented a SR after PHSC mobilization with Cyclophosphamide+G-CSF. The spleen removed showed hematopoietic foci and amiloid material. In the course of a second mobilization, 2 months after, the patient died from sepsis. We considered it important to report this case, in order to keep in mind the possibility of SR in patients with malignant gammopathy.
authors.affiliation: Servicio de Hematología, Hospital V Arrixaca, Murcia, Spain. mariac.funes@carm.es
authors.forename: Consuelo
authors.initials: C
authors.lastname: Funes
authors.forename: Faustino
authors.initials: F
authors.lastname: Garcia-Candel
authors.forename: Maria Juliana
authors.initials: MJ
authors.lastname: Majado
authors.forename: Consuelo
authors.initials: C
authors.lastname: González-García
authors.forename: Agueda
authors.initials: A
authors.lastname: Bas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Salido
authors.forename: Jose M
authors.initials: JM
authors.lastname: Moraleda
authors.forename: Alfonso
authors.initials: A
authors.lastname: Morales
mesh_terms: D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000150:complications*; D008875:Middle Aged; D013161:Splenic Rupture / Q000209:etiology*; D013163:Splenomegaly / Q000139:chemically induced; D014182:Transplantation, Autologous
chemical_list: D016179:Granulocyte Colony-Stimulating Factor