title: Neuroendocrine-type prostatic adenocarcinoma with microsatellite instability in a patient with lynch syndrome.
abstract: Lynch syndrome is an autosomal-dominant cancer syndrome that can be identified with microsatellite instability molecular tests or immunohistochemical stains on pathologic material from patients who meet the Amsterdam Criteria II. The development of prostatic carcinoma in situ or invasive small cell carcinoma (SCC) of the prostate has not been previously reported in a patient with this syndrome. In this report, an 87-year-old White man with the Lynch syndrome had a prostate biopsy that revealed a mixed high-grade conventional adenocarcinoma and SCC of the prostate with high-grade prostatic intraepithelial neoplasia of the small cell neuroendocrine-type (HGPIN-NE), all showing MSH2 microsatellite instability and loss of MSH2 expression, a finding not previously published. These findings suggest that HGPIN-NE is a precursor of invasive SCC and also that prostatic SCC can develop in a patient with the Lynch syndrome.
authors.affiliation: University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Wagner
authors.forename: Zoran
authors.initials: Z
authors.lastname: Gatalica
authors.forename: Henry T
authors.initials: HT
authors.lastname: Lynch
authors.forename: Shane
authors.initials: S
authors.lastname: Kohl
authors.forename: Sonny L
authors.initials: SL
authors.lastname: Johansson
authors.forename: Subodh M
authors.initials: SM
authors.lastname: Lele
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000235:genetics / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D055847:Lynch Syndrome II / Q000235:genetics / Q000473:pathology*; D008297:Male; D053842:Microsatellite Instability; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000235:genetics / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology*; D014516:Ureteral Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein