[Immunophysiological mechanism of origin and maintenance of tumor growth in humans].
A new concept of malignant tumor growth is presented. In consists in the fact that the tumor cells in the body occur in specific immune tolerance. As s result, they form around the center of regeneration, which consists of activated towards the regeneration cells of the immune system, which support the formation and growth of the tumor. In the early stages of differentiation, precancerous cells are not able to attract immune cells and form the focus of regeneration, so the majority of them die. At the outbreak of chronic inflammation, which contains a high percentage of regeneration of activated immune cells, the conditions exists for the formation of a focus of regeneration and, hence, growth and activation of precancerous cells and their transformation into high-grade malignant cells. This concept defines new approaches to treatment. For effective cancer therapy is necessary to neutralize the regenerator chamber in the tumor tissue. The effectiveness of the regeneration of damaged human tissues can be achieved through regenerator chamber similar to that created in the malignant tissue, and the introduction of a stem cell.
Lebedev
K A
KA
Poniakina
I D
ID
D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology