No evidence of microbleeds in ALS patients at 7 Tesla MRI.
There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.
Verstraete
Esther
E
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht. E.Verstraete@umcutrecht.nl
Biessels
Geert-Jan
GJ
van Den Heuvel
Martijn P
MP
Visser
Fredy
F
Luijten
Peter R
PR
van Den Berg
Leonard H
LH
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D001812:Blood-Brain Barrier / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002560:Cerebrovascular Circulation; D006485:Hemosiderin; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008833:Microcirculation; D008875:Middle Aged
D006485:Hemosiderin