title: Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies.
abstract: The current study evaluated 23 children (ages 2-16 years) with recurrent food intolerance and allergies for CoQ10 deficiency and mitochondrial abnormalities. Muscle biopsies were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain (MRC) activities. Group 2 (age >10 years; n = 9) subjects had significantly decreased muscle CoQ10 than Group 1 (age <10 y; n = 14) subjects (p = 0.001) and 16 controls (p<0.05). MRC activities were significantly lower in Group 2 than in Group 1 (p<0.05). Muscle CoQ10 levels in study subjects were significantly correlated with duration of illness (adjusted r(2) = 0.69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression.
authors.affiliation: Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.org
authors.forename: Michael V
authors.initials: MV
authors.lastname: Miles
authors.forename: Philip E
authors.initials: PE
authors.lastname: Putnam
authors.forename: Lili
authors.initials: L
authors.lastname: Miles
authors.forename: Peter H
authors.initials: PH
authors.lastname: Tang
authors.forename: Antonius J
authors.initials: AJ
authors.lastname: DeGrauw
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Wong
authors.forename: Paul S
authors.initials: PS
authors.lastname: Horn
authors.forename: Heather L
authors.initials: HL
authors.lastname: Foote
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004579:Electron Transport; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D005260:Female; D005512:Food Hypersensitivity / Q000209:etiology*; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D028361:Mitochondrial Diseases / Q000150:complications*; D052097:Quadriceps Muscle / Q000378:metabolism / Q000473:pathology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000172:deficiency
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10