One-pot desulfurative-fluorination-bromination. Synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes.
A unique one-pot, high-yield desulfurative-fluorination-bromination reaction which leads to the synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes is reported. A single dithiolane reactant can be used to produce both 2,5-dibromo-3-(1,1-difluoroalkyl)thiophene and 3-(1,1-difluoroalkyl)thiophene with longer alkyl chains.
Turkman
Nashaat
N
Department of Chemistry and Biochemistry, Box 19065, The University of Texas at Arlington, Arlington, Texas 76019-0065, USA.
An
Lingling
L
Pomerantz
Martin
M