title: A preformed scleral search coil for measuring mouse eye movements.
abstract: Mice are excellent subjects for use of genetic-manipulation techniques to study the basis of pathological and normal physiology and behavior; however behavioral analyses of associated phenotypes is often limited. To improve the accuracy and specificity of repeated measurements of vestibular function, we developed a miniaturized, contact-lens scleral search coil to measure mouse eye movements. We describe the physical attributes and document its functionality by measuring vestibuloocular responses in normal mice. This coil should greatly improve the sensitivity and documentation of vestibular dysfunction in mouse models of pathology and dysfunction while allowing screening of significant numbers of subjects.
authors.affiliation: Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA. kaneko@uw.edu
authors.forename: Chris R S
authors.initials: CR
authors.lastname: Kaneko
authors.forename: Sam
authors.initials: S
authors.lastname: Rosenfeld
authors.forename: Ethan
authors.initials: E
authors.lastname: Fontaine
authors.forename: Alex
authors.initials: A
authors.lastname: Markov
authors.forename: James O
authors.initials: JO
authors.lastname: Phillips
authors.forename: John
authors.initials: J
authors.lastname: Yarno
mesh_terms: D000818:Animals; D003261:Contact Lenses; D053483:Eye Movement Measurements / Q000295:instrumentation*; D005133:Eye Movements / Q000502:physiology*; D051379:Mice; D012590:Sclera / Q000502:physiology*; D014741:Video Recording
references.citation: J Neurophysiol. 1998 Feb;79(2):835-47
references.pmid: 9463445
references.citation: Optom Vis Sci. 1999 Jun;76(6):408-18
references.pmid: 10416936
references.citation: N Engl J Med. 2005 Apr 14;352(15):1557-64
references.pmid: 15829536
references.citation: Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1516-21
references.pmid: 17234811
references.citation: Brain Res. 2003 May 16;972(1-2):75-83
references.pmid: 12711080
references.citation: Neuron. 2003 Sep 11;39(6):1031-42
references.pmid: 12971901
references.citation: Nat Rev Neurosci. 2002 Nov;3(11):896-902
references.pmid: 12415297
references.citation: Nat Genet. 1998 Aug;19(4):390-4
references.pmid: 9697703
references.citation: Hear Res. 2007 Feb;224(1-2):51-60
references.pmid: 17208398
references.citation: Eur J Neurosci. 2001 Oct;14(7):1129-42
references.pmid: 11683905
references.citation: Brain Res. 2001 Feb 2;890(2):296-305
references.pmid: 11164796
references.citation: Hear Res. 2004 May;191(1-2):34-40
references.pmid: 15109702
references.citation: J Biol Chem. 1998 Jul 24;273(30):18693-6
references.pmid: 9668038
references.citation: Neuroscience. 2000;95(3):903-11
references.pmid: 10670457
references.citation: J Neurosci Methods. 2000 Jun 30;99(1-2):101-10
references.pmid: 10936649
references.citation: J Med Genet. 2000 Aug;37(8):581-7
references.pmid: 10922384
references.citation: Exp Eye Res. 2003 Dec;77(6):731-9
references.pmid: 14609561
references.citation: Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17078-82
references.pmid: 12466504
references.citation: Hematology. 2004 Aug;9(4):301-5
references.pmid: 15621739
references.citation: J Neurophysiol. 2004 May;91(5):2066-78
references.pmid: 14724264
references.citation: Genomics. 2001 Jun 1;74(2):228-33
references.pmid: 11386759
references.citation: Dev Dyn. 2002 Apr;223(4):517-25
references.pmid: 11921339
references.citation: Genetics. 1998 Oct;150(2):815-22
references.pmid: 9755211
references.citation: Laryngoscope. 2001 Jan;111(1):84-6
references.pmid: 11192904
references.citation: Neurosci Lett. 1999 May 28;267(2):93-6
references.pmid: 10400220
references.citation: Pharmacol Res. 1996 Feb;33(2):135-40
references.pmid: 8870029
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7705-10
references.pmid: 9636214