title: Mapping plasticity in the forepaw digit barrel subfield of rat brains using functional MRI.
abstract: The topographic organization of the forepaw barrel subfield in layer IV of rat primary somatosensory cortex (S1) is a good model for studying neural function and plasticity. The goal of this study was to test the feasibility of functional MRI (fMRI) to map the forepaw digit representations in the S1 of the rat and its plasticity after digit amputation. Three dimensional echo-planar imaging with 300 micron isotropic resolution at 11.7 T was used to achieve high signal-to-noise ratios and laminar layer resolution. By alternating electrical stimulation of the 2nd (D2) and 4th (D4) digits, functional activation in layer IV of the barrel subfields could be distinguished using a differential analysis. Furthermore, 2 and a half months after the amputation of the 3rd digit in baby rats, the overlapping area between D2 and D4 representations was increased. This indicates that the forepaw barrel subfield previously associated with the ablated digit is now associated with the representation of nearby digits, which is consistent with studies using electrophysiology and cytochrome oxidase staining.
authors.affiliation: Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Jun-Cheng
authors.initials: JC
authors.lastname: Weng
authors.forename: Kai-Hsiang
authors.initials: KH
authors.lastname: Chuang
authors.forename: Artem
authors.initials: A
authors.lastname: Goloshevsky
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Dodd
authors.forename: Kathryn
authors.initials: K
authors.lastname: Sharer
mesh_terms: D000671:Amputation, Surgical; D000818:Animals; D001931:Brain Mapping; D005552:Forelimb / Q000294:innervation*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009473:Neuronal Plasticity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000033:anatomy & histology*
references.citation: J Comp Neurol. 1987 Feb 8;256(2):246-56
references.pmid: 3558880
references.citation: Exp Brain Res. 1990;81(2):234-40
references.pmid: 1697807
references.citation: Magn Reson Med. 1997 Sep;38(3):378-88
references.pmid: 9339438
references.citation: Exp Brain Res. 1986;61(3):540-8
references.pmid: 3956614
references.citation: Magn Reson Med. 1993 Sep;30(3):387-92
references.pmid: 8412613
references.citation: Brain Res. 2008 Feb 21;1195:67-76
references.pmid: 18206862
references.citation: Brain Res. 1975 Jan 17;83(3):504-8
references.pmid: 1111817
references.citation: Neuroimage. 2006 May 1;30(4):1149-60
references.pmid: 16414284
references.citation: Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8381-3
references.pmid: 1518871
references.citation: Neurosci Lett. 1977 Nov;6(2-3):151-6
references.pmid: 19605044
references.citation: Neuroimage. 2008 Aug 1;42(1):28-35
references.pmid: 18550386
references.citation: Neuroimage. 2010 Jan 15;49(2):1667-76
references.pmid: 19770051
references.citation: Neuroimage. 2009 Jan 15;44(2):363-72
references.pmid: 18848997
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15182-7
references.pmid: 12407177
references.citation: Magn Reson Med. 2003 Apr;49(4):655-64
references.pmid: 12652536
references.citation: J Neurosci. 2004 Jan 21;24(3):634-41
references.pmid: 14736849
references.citation: Brain Res. 1976 Mar 12;104(2):309-15
references.pmid: 1260427
references.citation: Magn Reson Med. 1999 Feb;41(2):230-5
references.pmid: 10080267
references.citation: Neuroimage. 2000 Mar;11(3):188-202
references.pmid: 10694461
references.citation: J Neurophysiol. 1997 May;77(5):2780-7
references.pmid: 9163392
references.citation: Magn Reson Med. 2007 Feb;57(2):417-22
references.pmid: 17260372
references.citation: J Magn Reson Imaging. 2003 Jul;18(1):1-15
references.pmid: 12815634
references.citation: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10904-9
references.pmid: 11526212
references.citation: J Comp Neurol. 1986 Oct 15;252(3):404-14
references.pmid: 3793984
references.citation: J Comp Neurol. 1976 Nov 1;170(1):53-66
references.pmid: 977815
references.citation: J Comp Neurol. 1991 Jan 8;303(2):193-210
references.pmid: 1707420
references.citation: Neuroreport. 1996 Oct 2;7(14):2395-400
references.pmid: 8951859
references.citation: NMR Biomed. 2006 Aug;19(5):566-72
references.pmid: 16598695
references.citation: Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5951-5
references.pmid: 1631079
references.citation: Neuroimage. 2006 Jul 1;31(3):1238-46
references.pmid: 16632382
references.citation: Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5675-9
references.pmid: 1608978
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14114-9
references.pmid: 19666522
references.citation: Magn Reson Med. 2006 Feb;55(2):316-24
references.pmid: 16372281
references.citation: Magn Reson Med. 1999 Nov;42(5):919-28
references.pmid: 10542351
references.citation: Exp Brain Res. 1996 Mar;108(3):417-26
references.pmid: 8801121
references.citation: NMR Biomed. 2006 Feb;19(1):10-7
references.pmid: 16408324
references.citation: Neuroimage. 2005 Feb 1;24(3):667-77
references.pmid: 15652302
references.citation: Neuroimage. 2006 Apr 15;30(3):847-56
references.pmid: 16343952
references.citation: Cereb Cortex. 2008 Oct;18(10):2341-51
references.pmid: 18245039
references.citation: Neuron. 2001 Oct 25;32(2):359-74
references.pmid: 11684004
references.citation: Neuroimage. 2007 Aug 1;37(1):262-73
references.pmid: 17544301
references.citation: J Neurophysiol. 1994 Dec;72(6):2827-39
references.pmid: 7897492
references.citation: Annu Rev Neurosci. 1982;5:1-31
references.pmid: 6280572
references.citation: Magn Reson Med. 1993 Sep;30(3):380-6
references.pmid: 8412612
references.citation: Brain Res. 1970 Jan 20;17(2):205-42
references.pmid: 4904874
references.citation: Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1195-213
references.pmid: 10466146
references.citation: Neuroscience. 2010 Jan 13;165(1):252-64
references.pmid: 19799969
references.citation: J Neurosci. 2007 Aug 22;27(34):9181-91
references.pmid: 17715354
references.citation: Brain Res. 1983 Dec 19;289(1-2):65-70
references.pmid: 6661656
references.citation: Curr Opin Neurobiol. 2002 Oct;12(5):607-15
references.pmid: 12367643
references.citation: Proc R Soc Lond B Biol Sci. 1979 Mar 26;204(1154):41-55
references.pmid: 37512
references.citation: Exp Brain Res. 1995;103(2):183-97
references.pmid: 7789426
references.citation: Proc Natl Acad Sci U S A. 1980 Apr;77(4):2333-7
references.pmid: 6246540
references.citation: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):475-8
references.pmid: 8552664
references.citation: J Comp Neurol. 1991 Jan 8;303(2):211-24
references.pmid: 2013636
references.citation: NMR Biomed. 1994 Mar;7(1-2):69-74
references.pmid: 8068528
references.citation: J Neurosci. 2006 Nov 15;26(46):11821-32
references.pmid: 17108155
references.citation: J Comp Neurol. 1976 Mar 15;166(2):173-89
references.pmid: 770516
references.citation: Magn Reson Med. 2004 Mar;51(3):518-24
references.pmid: 15004793