Apollo-taking the lead in telomere protection.
The single-stranded overhangs at the ends of telomeres are thought to be critical for telomere maintenance, but how they are generated has been largely unclear. Two studies (one in this issue of Molecular Cell, Wu et al., 2010) have now implicated the Apollo nuclease in maintaining the overhang specifically at those telomeres generated by leading-strand DNA synthesis.
Sarthy
Jay F
JF
Howard Hughes Medical Institute and Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Baumann
Peter
P