[Preparation of As2O3 nanoparticles and its drug release characteristics in vitro].
OBJECTIVE
To prepare arsenic trioxide (As2O3)-loaded biodegradable polylactic-co-glycolic acid (PLGA) nanoparticles (NPS) and evaluate the glomeration ability, appearance, structure, surface and release characteristics of the NPs.


METHODS
With PLGA as the carrier material, As2O3 NPs (As2O3-NPS) were prepared with the method of matrix and ultrasound emulsification. According to the criteria of the diameter of the NPs, drug loading (DL) and embedding ratio (ER), the process of NP preparation was optimized by scanning electron microscopy (SEM), ultraviolet spectroscopy (UV), and XPS.


RESULTS
The As2O3-NPS prepared were uniformly spherical with an average diameter of 210-/+23 nm, DL of 29.6% and ER of 82.1%. The drug release assay in vitro showed a sustained drug-release capacity of the preparation.


CONCLUSIONS
As2O3-NPS may serve as a carrier of As2O3 to change the pharmacokinetics of As2O3 in vivo, allow slow drug release, and prolong the drug circulation time after intravenous injection, thereby producing better antitumor effects.
Xu
Li-shu
LS
Department of Gastroenterology, East District of Guangdong General Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Liu
Jian-hu
JH
Lin
Ping
P
Huang
Kai-hong
KH
Chen
Yin-ting
YT
Chen
Qi-kui
QK
D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D004337:Drug Carriers; D053758:Nanoparticles; D010087:Oxides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D010316:Particle Size; D011100:Polyglycolic Acid
D001152:Arsenicals; D004337:Drug Carriers; D010087:Oxides; D011100:Polyglycolic Acid; D000077237:Arsenic Trioxide