title: Guaroa virus infection among humans in Bolivia and Peru.
abstract: Guaroa virus (GROV) was first isolated from humans in Colombia in 1959. Subsequent isolates of the virus have been recovered from febrile patients and mosquitoes in Brazil, Colombia, and Panama; however, association of the virus with human disease has been unclear. As part of a study on the etiology of febrile illnesses in Peru and Bolivia, 14 GROV strains were isolated from patients with febrile illnesses, and 3 additional cases were confirmed by IgM seroconversion. The prevalence rate of GROV antibodies among Iquitos residents was 13%; the highest rates were among persons with occupations such as woodcutters, fisherman, and oil-field workers. Genetic characterization of representative GROV isolates indicated that strains from Peru and Bolivia form a monophyletic group that can be distinguished from strains isolated earlier in Brazil and Colombia. This study confirms GROV as a cause of febrile illness in tropical regions of Central and South America.
authors.affiliation: Naval Medical Research Center Detachment, Lima, Peru. patricia.aguilar@med.navy.mil
authors.forename: Patricia V
authors.initials: PV
authors.lastname: Aguilar
authors.forename: Amy C
authors.initials: AC
authors.lastname: Morrison
authors.forename: Claudio
authors.initials: C
authors.lastname: Rocha
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Watts
authors.forename: Luis
authors.initials: L
authors.lastname: Beingolea
authors.forename: Victor
authors.initials: V
authors.lastname: Suarez
authors.forename: Jorge
authors.initials: J
authors.lastname: Vargas
authors.forename: Cristhopher
authors.initials: C
authors.lastname: Cruz
authors.forename: Carolina
authors.initials: C
authors.lastname: Guevara
authors.forename: Joel M
authors.initials: JM
authors.lastname: Montgomery
authors.forename: Robert B
authors.initials: RB
authors.lastname: Tesh
authors.forename: Tadeusz J
authors.initials: TJ
authors.lastname: Kochel
mesh_terms: D001838:Bolivia / Q000453:epidemiology; D006801:Humans; D016851:Orthobunyavirus / Q000502:physiology*; D010568:Peru / Q000453:epidemiology
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