title: Neurodevelopmental and behavioral outcome of very low birth weight babies at corrected age of 2 years.
abstract: OBJECTIVE
  Neurodevelopmental and behavioral assessment of very low birth weight babies (VLBW) at corrected age (CA) of 2 years.
  
  
  METHODS
  127, 110, 99 and 101 babies ≤34 weeks and ≤1500 g were followed at CA of 3, 6, 9, 12 months respectively for developmental and neurological assessment. DASII (Developmental assessment scale for Indian infants) was used at CA of 18 months and preschool behavioural checklist (PBCL) at CA 2 years.
  
  
  RESULTS
  Of 101 VLBW babies available for follow up at CA 1 year, 3 (3%) babies had Cerebral Palsy (CP) and 3% (n = 3) had suspect abnormality (mild hypotonia), 11% (n = 11) had gross motor and 8% (n = 8) had language abnormality. Their mean mental (MeDQ) and motor (MoDQ) quotients were 80.4 ± 10.7 and 77.2 ± 13.3 and a score of < 70 was found in 17% (MeDQ) and 25.7% (MoDQ) VLBW babies. High PBCL score (mean 16.8 ± 5.4) was seen in 84%VLBW babies. On subgroup analysis, 2 babies (5%) in subgroup1 ( n = 54, ≤1200 g,) and 1 (1.6%) in subgroup 2 (n = 78, 1201-1500 g) had CP. Twelve (29%) in subgroup 1 had significant language delay (p = 0.004) as compared to 4 (15%) in subgroup 2 at 1 year. BSID and PBCL scores were comparable. Amongst ELBW babies (<1000 g), 6.6% (n = 1) had CP, 25% (n = 3) and 42% (n = 5) had low MeDQ and MoDQ respectively and all of them had high PBCL score. AGA and SGA had similar outcome.
  
  
  CONCLUSIONS
  VLBW babies need close and longer follow up due to high risk of neurodevelopmental and behavioral abnormality.
authors.affiliation: Department of Pediatrics, PGIMER, Chandigarh 160012, India. kanyapupul@yahoo.com
authors.forename: Kanya
authors.initials: K
authors.lastname: Mukhopadhyay
authors.forename: Prahbhjot
authors.initials: P
authors.lastname: Malhi
authors.forename: Rama
authors.initials: R
authors.lastname: Mahajan
authors.forename: Anil
authors.initials: A
authors.lastname: Narang
mesh_terms: D000367:Age Factors; D002547:Cerebral Palsy / Q000175:diagnosis / Q000453:epidemiology; D016009:Chi-Square Distribution; D002653:Child Behavior Disorders; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D007223:Infant; D018730:Infant Behavior; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D015278:Intensive Care Units, Pediatric; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000453:epidemiology; D011446:Prospective Studies; D018570:Risk Assessment; D012737:Sex Factors
references.citation: Hong Kong Med J. 2008 Feb;14(1):21-8
references.pmid: 18239239
references.citation: Arch Dis Child Fetal Neonatal Ed. 2000 May;82(3):F208-14
references.pmid: 10794788
references.citation: J Paediatr Child Health. 1999 Apr;35(2):175-80
references.pmid: 10365356
references.citation: Lancet. 2007 Jan 6;369(9555):43-50
references.pmid: 17208641
references.citation: Indian Pediatr. 1996 Aug;33(8):645-53
references.pmid: 8979547
references.citation: Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1632-9
references.pmid: 9855609
references.citation: Indian Pediatr. 2007 Apr;44(4):286-90
references.pmid: 17468524
references.citation: Indian Pediatr. 1999 Jul;36(7):669-76
references.pmid: 10740303
references.citation: Arch Dis Child Fetal Neonatal Ed. 1998 Jul;79(1):F12-20
references.pmid: 9797619
references.citation: J Child Psychol Psychiatry. 1986 Jan;27(1):7-32
references.pmid: 3949908
references.citation: Pediatrics. 1963 Nov;32:793-800
references.pmid: 14075621
references.citation: Pediatrics. 2007 Jan;119(1):37-45
references.pmid: 17200269
references.citation: Pediatrics. 2005 Apr;115(4):997-1003
references.pmid: 15805376
references.citation: Indian Pediatr. 1991 Aug;28(8):873-80
references.pmid: 1808074
references.citation: Pediatrics. 2000 Jun;105(6):1216-26
references.pmid: 10835060