[Effect of cysteine lithium salt on lipid peroxidation in the model of dopaminergic system disorder].
The antioxidant activity of a newly synthesized compound, cysteine lithium salt, was discovered using methyl oleate oxidation model of dopaminergic system disorder. Experimental data show that injection of the synthesized compound in animals with experimentally induced L-DOPA brings to normalization effect conditioned by inhibiting free radical reactions in the nuclear and mitochondrial fractions of brain cells. Antioxidant effect of the synthesized compound is related to its chemical structure that contains cysteine--an agent involved in the biosynthesis of glutathione, which is a component of glutathione peroxidase and glutathione reductase enzymes participating in the antiradical protection system.
Ovsepian
L M
LM
Kazarian
G V
GV
Zakharian
A V
AV
Zakarian
G V
GV
L'vov
M V
MV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D007980:Levodopa / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008094:Lithium; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009829:Oleic Acids / Q000737:chemistry; D051381:Rats
D000975:Antioxidants; D008054:Lipid Peroxides; D009829:Oleic Acids; C005576:methyl oleate; D007980:Levodopa; D008094:Lithium; D003545:Cysteine; D004298:Dopamine