title: Fetal epigenetic mechanisms and innate immunity in asthma.
abstract: Allergy and asthma are chronic inflammatory diseases that result from complex gene-environment interactions. Recent evidence points to the importance of prenatal and postnatal developmental processes in the maturation of balanced immune responses. Novel data indicate that epigenetic mechanisms contribute to the development of T-helper-cell function. Environmental factors, including diesel exhaust particles, vitamins, and tobacco smoke, operate through such mechanisms. Furthermore, the role of environmental microbes provides another-and maybe an even more important-group of exogenous exposures that operate in this critical time frame. A better understanding of fetal immuno-maturation conditions will provide the basis for the development of novel allergo-protective clinical strategies.
authors.affiliation: Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Germany.
authors.forename: Petra Ina
authors.initials: PI
authors.lastname: Pfefferle
authors.forename: Olaf
authors.initials: O
authors.lastname: Pinkenburg
authors.forename: Harald
authors.initials: H
authors.lastname: Renz
mesh_terms: D001249:Asthma / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D044127:Epigenesis, Genetic / Q000276:immunology*; D005260:Female; D047109:Fetal Development / Q000276:immunology*; D005333:Fetus / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
references.citation: Eur J Immunol. 2004 Dec;34(12):3604-13
references.pmid: 15484194
references.citation: Clin Exp Allergy. 2005 Mar;35(3):397-402
references.pmid: 15784121
references.citation: Science. 2010 Jan 15;327(5963):291-5
references.pmid: 20075244
references.citation: Toxicol Sci. 2008 Mar;102(1):76-81
references.pmid: 18042818
references.citation: J Immunol. 2003 Sep 1;171(5):2510-6
references.pmid: 12928400
references.citation: PLoS One. 2009 Nov 09;4(11):e7711
references.pmid: 19898617
references.citation: J Allergy Clin Immunol. 2009 Jul;124(1):170; author reply 170-1
references.pmid: 19427684
references.citation: J Allergy Clin Immunol. 2008 Jan;121(1):116-121.e11
references.pmid: 18206506
references.citation: Clin Exp Allergy. 2002 Jan;32(1):43-50
references.pmid: 12002736
references.citation: Immunity. 2004 Dec;21(6):865-76
references.pmid: 15589174
references.citation: J Immunol. 2007 Jun 15;178(12):7805-13
references.pmid: 17548618
references.citation: Am J Respir Crit Care Med. 2008 Mar 15;177(6):567-73
references.pmid: 18187692
references.citation: Epidemiology. 2006 Mar;17(2):138-44
references.pmid: 16477253
references.citation: J Toxicol Sci. 2009;34 Suppl 2:SP341-8
references.pmid: 19571489
references.citation: Curr Opin Allergy Clin Immunol. 2008 Dec;8(6):557-64
references.pmid: 18978472
references.citation: J Allergy Clin Immunol. 2010 Jan;125(1):108-15.e1-3
references.pmid: 19969338
references.citation: Curr Opin Allergy Clin Immunol. 2009 Feb;9(1):38-43
references.pmid: 19106699
references.citation: J Allergy Clin Immunol. 2008 Aug;122(2):391-9, 399.e1-5
references.pmid: 18571707
references.citation: Gut. 2004 Nov;53(11):1602-9
references.pmid: 15479680
references.citation: J Allergy Clin Immunol. 2007 Jun;119(6):1514-21
references.pmid: 17481709
references.citation: Clin Exp Allergy. 2007 Mar;37(3):348-57
references.pmid: 17359385
references.citation: Annu Rev Immunol. 2006;24:607-56
references.pmid: 16551261
references.citation: Immunol Allergy Clin North Am. 2008 Aug;28(3):631-47, ix-x
references.pmid: 18572111
references.citation: EMBO J. 2006 Jun 7;25(11):2443-52
references.pmid: 16724115
references.citation: J Clin Invest. 2008 Oct;118(10):3462-9
references.pmid: 18802477
references.citation: Respir Res. 2006 Mar 21;7:40
references.pmid: 16551363
references.citation: J Allergy Clin Immunol. 2009 Nov;124(5):1078-87
references.pmid: 19895995
references.citation: J Exp Med. 2005 Mar 21;201(6):981-91
references.pmid: 15781587
references.citation: Nat Immunol. 2002 Jul;3(7):652-8
references.pmid: 12055627
references.citation: J Exp Med. 2009 Dec 21;206(13):2869-77
references.pmid: 19995952
references.citation: Mol Cell Biol. 2003 Aug;23(15):5293-300
references.pmid: 12861015
references.citation: J Infect Dis. 2009 Jun 15;199(12):1846-50
references.pmid: 19426111
references.citation: Pediatr Allergy Immunol. 2006 Feb;17(1):4-10
references.pmid: 16426248
references.citation: Hum Genet. 2008 Jun;123(5):455-68
references.pmid: 18401594
references.citation: Am J Respir Crit Care Med. 2010 Jul 1;182(1):25-33
references.pmid: 20194818
references.citation: J Immunol. 2002 Mar 15;168(6):2820-7
references.pmid: 11884451
references.citation: Clin Exp Allergy. 2009 Jan;39(1):20-32
references.pmid: 19128351
references.citation: Ann Epidemiol. 2008 May;18(5):343-50
references.pmid: 18433665
references.citation: Allergy. 2010 Jan;65(1):7-15
references.pmid: 19796189
references.citation: J Biol Chem. 2010 Jan 22;285(4):2545-53
references.pmid: 19923223
references.citation: Brain Behav Immun. 2006 Jul;20(4):317-24
references.pmid: 16226007
references.citation: Pediatr Res. 2001 Jan;49(1):81-3
references.pmid: 11134496
references.citation: Clin Exp Immunol. 2006 Feb;143(2):249-59
references.pmid: 16412048
references.citation: Chest. 2005 Apr;127(4):1232-41
references.pmid: 15821200
references.citation: Allergy. 2003 Oct;58(10):1053-8
references.pmid: 14510725
references.citation: PLoS One. 2009;4(2):e4488
references.pmid: 19221603
references.citation: Crit Rev Oncol Hematol. 2005 Jul;55(1):1-11
references.pmid: 15886007
references.citation: Adv Exp Med Biol. 2009;653:15-34
references.pmid: 19799109
references.citation: J Periodontol. 2008 Aug;79(8 Suppl):1514-9
references.pmid: 18673005