title: Embryology of the conduction system for the electrophysiologist.
abstract: It is critical for interventional electrophysiologists to thoroughly appreciate the topographic and developmental anatomy of the heart and its conduction system. Not only is understanding cardiac anatomy important to prevent complications from collateral damage and to help guide catheter placement, but developmental anatomy allows a deeper appreciation of the arrhythmogenic substrate. In this article, we briefly review the relevant stages of cardiac development for electrophysiologists. The potential location of normal and abnormal conduction patterns resulting from heterogeneous developmental origin is discussed.
authors.affiliation: Mayo Medical School.
authors.forename: Sultan
authors.initials: S
authors.lastname: Mirzoyev
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McLeod
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Asirvatham
references.citation: Dev Dyn. 2000 Jul;218(3):414-25
references.pmid: 10878607
references.citation: Heart. 2003 Jul;89(7):806-14
references.pmid: 12807866
references.citation: Development. 1997 Jun;124(11):2099-117
references.pmid: 9187138
references.citation: Am J Cardiol. 1983 Dec 1;52(10):1264-6
references.pmid: 6650414
references.citation: Circ Res. 2009 Sep 25;105(7):620-30
references.pmid: 19797194
references.citation: Annu Rev Physiol. 2001;63:235-57
references.pmid: 11181956
references.citation: Dev Dyn. 1995 Dec;204(4):358-71
references.pmid: 8601030
references.citation: Circ Res. 1994 Jun;74(6):1065-70
references.pmid: 8187276
references.citation: Am J Pathol. 1974 Feb;74(2):331-44
references.pmid: 4811758
references.citation: Chest. 2000 Jun;117(6):1740-8
references.pmid: 10858411
references.citation: Circ Res. 1999 Jun 25;84(12):1365-79
references.pmid: 10381888
references.citation: Circ Res. 1997 May;80(5):749-50
references.pmid: 9130456
references.citation: Dev Dyn. 2004 Apr;229(4):763-70
references.pmid: 15042700
references.citation: Pediatr Cardiol. 2004 May-Jun;25(3):191-200
references.pmid: 15360112
references.citation: J Biol Chem. 1985 Jun 10;260(11):6514-7
references.pmid: 2987225
references.citation: Science. 1998 Jul 3;281(5373):108-11
references.pmid: 9651244
references.citation: Cardiovasc Res. 1996 Apr;31(4):480-91
references.pmid: 8689639
references.citation: Pediatr Res. 2005 Feb;57(2):169-76
references.pmid: 15611355
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1272-80
references.pmid: 17075847
references.citation: J Physiol. 2003 Sep 15;551(Pt 3):801-13
references.pmid: 12847206
references.citation: Birth Defects Res C Embryo Today. 2003 Feb;69(1):46-57
references.pmid: 12768657
references.citation: Heart Rhythm. 2005 Aug;2(8):875-86
references.pmid: 16051128
references.citation: Circ Res. 1989 Aug;65(2):360-9
references.pmid: 2752545
references.citation: J Cardiovasc Electrophysiol. 1999 Nov;10(11):1525-33
references.pmid: 10571372
references.citation: J Thorac Cardiovasc Surg. 1998 Jul;116(1):36-46
references.pmid: 9671895
references.citation: Dev Biol. 1982 Jan;89(1):25-40
references.pmid: 7054008
references.citation: J Am Coll Cardiol. 1988 May;11(5):1035-40
references.pmid: 3128586
references.citation: Minerva Cardioangiol. 1992 Oct;40(10):353-8
references.pmid: 1488132
references.citation: Europace. 2009 Nov;11 Suppl 5:v15-21
references.pmid: 19861386
references.citation: Circ Arrhythm Electrophysiol. 2009 Apr;2(2):195-207
references.pmid: 19808465
references.citation: Circ Res. 2005 Apr 15;96(7):776-83
references.pmid: 15761198
references.citation: Circ Res. 1998 Apr 6;82(6):629-44
references.pmid: 9546372
references.citation: Folia Morphol (Warsz). 1997;56(1):31-9
references.pmid: 9409077
references.citation: Br Heart J. 1986 Oct;56(4):380-4
references.pmid: 3094566
references.citation: Circ Res. 2006 Jun 23;98(12):1547-54
references.pmid: 16709902
references.citation: Clin Anat. 2003 Sep;16(5):389-95
references.pmid: 12903060
references.citation: Chest. 1990 Jul;98(1):129-32
references.pmid: 2361378
references.citation: Cardiol Young. 2001 Nov;11(6):632-42
references.pmid: 11813915
references.citation: Physiol Rev. 2003 Oct;83(4):1223-67
references.pmid: 14506305
references.citation: Mech Dev. 2001 Oct;108(1-2):105-19
references.pmid: 11578865
references.citation: Circ Res. 1996 Jan;78(1):110-7
references.pmid: 8603493
references.citation: Science. 1983 Jun 3;220(4601):1059-61
references.pmid: 6844926
references.citation: Acta Cardiol. 1985;40(2):229-35
references.pmid: 3873158
references.citation: Heart. 2002 Jul;88(1):104-10
references.pmid: 12067964
references.citation: Cardiovasc Res. 1997 Oct;36(1):101-10
references.pmid: 9415278
references.citation: Dev Biol. 1977 Apr;56(2):397-411
references.pmid: 849806
references.citation: Dev Genet. 1999;24(1-2):82-90
references.pmid: 10079513
references.citation: Annu Rev Physiol. 1999;61:283-310
references.pmid: 10099690
references.citation: N Engl J Med. 1998 Sep 3;339(10):659-66
references.pmid: 9725923
references.citation: Anat Rec. 1992 Jan;232(1):97-111
references.pmid: 1536469
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13214-8
references.pmid: 10557300
references.citation: Am J Cardiol. 1988 Oct 1;62(10 Pt 1):733-5
references.pmid: 3138904
references.citation: ScientificWorldJournal. 2007 Nov 12;7:1777-98
references.pmid: 18040540
references.citation: J Cardiovasc Electrophysiol. 2003 Aug;14(8):803-9
references.pmid: 12890038