Lung cancer and environmental chemical exposure: a review of our current state of knowledge with reference to the role of hormones and hormone receptors as an increased risk factor for developing lung cancer in man.
Lung cancer is a dominant cause of cancer mortality. The etiology of lung cancer is mainly related to cigarette smoking, airborne genotoxic carcinogens, and arsenic, but its sex-specific incidence suggests that other mechanisms, such as hormones, may also be involved in the process of carcinogenesis. A number of agents commonly present in the living environment can have dual biological effects: not only are they genotoxic / carcinogenic, but they are also hormonally active as xenoestrogens. This dualism may explain sex-specific differences reported in both types and incidence of lung cancer. In a novel approach to investigate the complexity of lung cancer, etiology, including systems biology, will be used as a tool for a simultaneous interpretation of measurable environmental and biological parameters. Using this approach, the etiology of human lung cancer can be more thoroughly investigated using the available data from oncology and environmental health. The information gained could be applied in the introduction of preventive measures, in personalized medicine, and in more relevant legislation, which should be adjusted to reflect the current knowledge on the complex environmental interactions underlying this life-threatening disease.
Fucic
Alexsandra
A
Institute for Medical Research and Occupational Health, Zagreb, Croatia. afucic@imi.hr
Gamulin
Marija
M
Ferencic
Zeljko
Z
Rokotov
Dinko Stancic
DS
Katic
Jelena
J
Bartonova
Alena
A
Lovasic
Ingrid Belac
IB
Merlo
Domenico Franco
DF
D016902:Air Pollution, Indoor / Q000009:adverse effects; D000398:Air Pollution, Radioactive / Q000009:adverse effects; D002274:Carcinogens, Environmental / Q000378:metabolism / Q000633:toxicity*; D015984:Causality; D004781:Environmental Exposure / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D011886:Radon / Q000633:toxicity; D011987:Receptors, Steroid / Q000187:drug effects* / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism / Q000633:toxicity*
D002274:Carcinogens, Environmental; D004968:Estrogens, Non-Steroidal; D011987:Receptors, Steroid; D015262:Xenobiotics; D011886:Radon