title: [Current approaches to treating acute gastroduodenal ulcer bleedings].
abstract: The aim of the work was analysis of treatment of 560 patients with a gastrointestinal bleeding from acute ulcers. For estimation of patients was used universal integrated scale APACHE III. Tactics of treatment depend on secretory functions of a stomach and group of polyorganical difunction. At 428 (76,5%) patients with acute ulcers on the background increase secretion of stomach was treatment antysecretion therapy. At 132 (23,5%) patients with acute ulcers on the background of normal ore decrease secretion of stomach was treatment Cytoflavin - the metabolic preparation possessing antyoxidation, cytoprotection and immunomodulaytion activity. For studying antyoxidation and antihypoxation actions of Cytoflavin estimated of microcirculation mucous of a stomach with the laser Doppler floymetrya before course of treatment, observed increase of index efficiency of microcirculation and increase a blood-groove in a stomach at patients with acute peptic ulcers on a background of treatment of Cytoflavin. After course of treatment of Cytoflavin decrease in points on system APACHE III on 5,5-25% at all patients that has led to decrease mortality on 20% in this group of patients.
authors.forename: V A
authors.initials: VA
authors.lastname: Stupin
authors.forename: S V
authors.initials: SV
authors.lastname: Siluianov
authors.forename: G O
authors.initials: GO
authors.lastname: Smirnov
authors.forename: M A
authors.initials: MA
authors.lastname: Sobirov
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D004338:Drug Combinations; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000098:blood supply; D006801:Humans; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D013386:Succinates / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate