title: Squamous cell carcinoma arising from a localized vulval lesion of Hailey-Hailey disease after tacrolimus therapy.
abstract: Hailey-Hailey disease (HHD) is a rare, autosomal dominant intraepidermal blistering disorder characterized by recurrent vesicles and erosions affecting mostly the intertriginous areas. We report a case of HHD affecting exclusively the vulva from which an invasive squamous cell carcinoma developed after tacrolimus therapy.
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany. vvonfelbert@ukaachen.de
authors.forename: Verena
authors.initials: V
authors.lastname: von Felbert
authors.forename: Monika
authors.initials: M
authors.lastname: Hampl
authors.forename: Carolina
authors.initials: C
authors.lastname: Talhari
authors.forename: Rainer
authors.initials: R
authors.lastname: Engers
authors.forename: Mosaad
authors.initials: M
authors.lastname: Megahed
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008197:Lymph Node Excision; D016506:Pemphigus, Benign Familial / Q000188:drug therapy*; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects*; D014845:Vulvar Diseases / Q000188:drug therapy*; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus