title: [Oligonucleotides with peptide internucleotide linkage. A novel class of modified oligonucleotides].
abstract: Oligonucleotide analogues with replacement of one or more internucleotide phosphodiester linkages with glycine, L- and D-alanine residues have been synthesized (C3'-NH-C(O)-CH(X)-NH-C(O)-C4', X = H, (S)-CH3 and (R)-CH3). The stability of the duplexes formed by the modified oligonucleotides and their wild-type complements have been studied. Incorporation of glycine and L-alanine residues have been shown to substantially decrease the stability the modified duplexes in comparison with that of the wild-type ones (DeltaT(m) approximately -2 degrees C per modification), while the analogs with D-alanine-containing linkages appeared to form duplexes with increased stability (DeltaT(m), approximately +0.2 degrees C per modification).
authors.forename: A M
authors.initials: AM
authors.lastname: Varizhuk
authors.forename: S V
authors.initials: SV
authors.lastname: Kochetkova
authors.forename: N A
authors.initials: NA
authors.lastname: Kolganova
authors.forename: É N
authors.initials: ÉN
authors.lastname: Timofeev
authors.forename: V L
authors.initials: VL
authors.lastname: Florent'ev
mesh_terms: D000409:Alanine / Q000737:chemistry; D005998:Glycine / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D020135:Peptide Nucleic Acids; D000409:Alanine; D005998:Glycine