title: [Effect of H3R agonist, IMETIT on allergic rhinitis in guinea pigs].
abstract: OBJECTIVE
  To discuss the treatment of H3R agonist, IMETIT, on the allergic rhinitis(AR) ,and the influence to mRNA of Substance P(SP) and Substance P Receptor (SP-R) in AR model of guinea pigs.
  
  
  METHODS
  The severity of AR was assessed by allergic symptoms (sneezing, nasal rubbing and nose blocking). The changes in the nasal mucosa were studied by pathological methods. The expression of SP positive cell was detected by immunohistochemistry, and the expression of SP-R mRNA was detected by reverse transcriptive polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  Histamine H3R agonists, IMETIT can effectively improve the AR symptoms, sneezing, nasal itching, nasal congestion, reduce the pathological changes in the nasal mucosa, cut down the SP secretion and SP-R mRNA expression.
  
  
  CONCLUSIONS
  Histamine H3R agonist, IMETIT can effectively relieve the symptoms of AR in guinea pigs, which is related to reducing SP secretion and SP-R mRNA expression.
authors.affiliation: Xuzhou Medical College, Xuzhou, 221002, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Yang
authors.forename: Guangming
authors.initials: G
authors.lastname: Sun
authors.forename: Xuegu
authors.initials: X
authors.lastname: Xu
authors.forename: Peihua
authors.initials: P
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D018100:Receptors, Histamine H3 / Q000187:drug effects; D018040:Receptors, Neurokinin-1 / Q000235:genetics / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D007093:Imidazoles; D018100:Receptors, Histamine H3; D018040:Receptors, Neurokinin-1; D013373:Substance P; C077430:imetit; D013890:Thiourea