title: DNA binding, antioxidant and antimicrobial activities of homo- and heteronuclear copper(II) and nickel(II) complexes with new oxime-type ligands.
abstract: Some homo- and heteronuclear Cu(II) and Ni(II) complexes of new oxime-type ligands were tested against several pathogenic microorganisms to assess their antimicrobial potentials. The antimicrobial activities of complexes were evaluated in terms of minimum inhibitory concentration (MIC; μg/μL) and it was observed that the complexes possess moderate antimicrobial properties. The binding of the complexes with DNA were also investigated by using UV-Vis spectroscopy. It was seen that three of the complexes could bind to DNA through an intercalative mode while the other complexes could have other mechanisms. Furthermore, the antioxidant efficiencies of the metal complexes were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radical scavening activities. Due to the observed IC(50) values, they are potential drugs to eliminate the radicals.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey. acolak@ktu.edu.tr
authors.forename: Ahmet
authors.initials: A
authors.lastname: Colak
authors.forename: Ülkü
authors.initials: Ü
authors.lastname: Terzi
authors.forename: Melek
authors.initials: M
authors.lastname: Col
authors.forename: Şengül Alpay
authors.initials: ŞA
authors.lastname: Karaoglu
authors.forename: Serdar
authors.initials: S
authors.lastname: Karaböcek
authors.forename: Aslıgül
authors.initials: A
authors.lastname: Küçükdumlu
authors.forename: Faik Ahmet
authors.initials: FA
authors.lastname: Ayaz
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*; D010851:Picrates; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D008024:Ligands; D010091:Oximes; D010851:Picrates; D003300:Copper; D009532:Nickel; D004247:DNA; C004931:1,1-diphenyl-2-picrylhydrazyl