title: [Description and investigation of an outbreak of extended-spectrum beta-lactamase producing Escherichia coli strain in a neonatal unit].
abstract: An outbreak of colonization and infection with an Escherichia coli strain producing extended-spectrum beta-lactamase (ESBL) occurred in a neonatal unit : a high rate of cases was observed, 27/59 neonates were colonized : one of them developed meningitis with favourable outcome and another baby developed conjunctivitis. Despite intensive efforts to control the outbreak by standard methods of hand hygiene, patients screening and isolation, the spread was uncontrolled and the unit was closed to all admission in order to stop the outbreak. The investigation was not able to identify a single outbreak's source. Emergence and spread of ESBL producing E. coli strains from community and hospital acquired infections are a significant public health problem with difficult choice of treatment for serious infections.
authors.affiliation: Service de Pédiatrie Générale, Hôpital Armand Trousseau, 26, Avenue du Docteur Arnold-Netter, 75571 Paris cedex 12, France. beatrice.quinet@trs.aphp.fr
authors.forename: B
authors.initials: B
authors.lastname: Quinet
authors.forename: D
authors.initials: D
authors.lastname: Mitanchez
authors.forename: B
authors.initials: B
authors.lastname: Salauze
authors.forename: A
authors.initials: A
authors.lastname: Carbonne
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: S
authors.initials: S
authors.lastname: Fournier
authors.forename: D
authors.initials: D
authors.lastname: Moissenet
authors.forename: H
authors.initials: H
authors.lastname: Vu-Thien
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000453:epidemiology; D004196:Disease Outbreaks; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology*; D005602:France; D006271:Health Facility Closure; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D015931:Intensive Care, Neonatal; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology; D007711:Klebsiella pneumoniae / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents