Update on the mechanisms of gastric acid secretion.
Acid-related disorders represent a major healthcare concern. In recent years, our understanding of the physiologic processes underlying gastric acid secretion has improved notably. The identity of several apical ion transport proteins, which are necessary for acid secretion to take place, has been resolved. The recent developments have uncovered potential therapeutic targets for the treatment of acid-related disorders. This brief review provides an update on the mechanisms of gastric acid secretion, with a particular focus on apical ion transport.
Kopic
Sascha
S
Departments of Surgery and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Geibel
John P
JP
D000818:Animals; D002712:Chlorides / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase / Q000502:physiology*; D006632:Histamine / Q000502:physiology; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000502:physiology; D026901:Membrane Transport Proteins / Q000502:physiology; D010295:Parietal Cells, Gastric / Q000502:physiology; D054328:Proton Pump Inhibitors / Q000494:pharmacology; D044169:Receptors, Calcium-Sensing / Q000502:physiology
D002712:Chlorides; D051657:KCNQ1 Potassium Channel; D026901:Membrane Transport Proteins; D054328:Proton Pump Inhibitors; D044169:Receptors, Calcium-Sensing; D006632:Histamine; D017506:H(+)-K(+)-Exchanging ATPase
J Biol Chem. 2009 Jul 24;284(30):20147-54
19491099
Am J Physiol. 1990 Oct;259(4 Pt 1):G536-43
1699427
J Clin Invest. 2000 Dec;106(12):1447-55
11120752
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17955-60
19004773
Biochemistry. 2005 Apr 12;44(14):5267-84
15807521
Gastroenterology. 1995 Oct;109(4):1134-41
7557078
Am J Physiol Cell Physiol. 2000 Aug;279(2):C375-82
10913004
J Physiol Sci. 2009 Jan;59(1):23-9
19340558
EMBO J. 2001 Mar 15;20(6):1289-99
11250895
Am J Physiol Cell Physiol. 2002 Apr;282(4):C805-16
11880269
FEBS Lett. 2004 Sep 24;575(1-3):105-8
15388342
Pflugers Arch. 2009 Nov;459(1):39-46
19621238
J Biochem. 2005 Sep;138(3):293-301
16169880
Genomics. 1991 Oct;11(2):435-42
1663071
Cell Physiol Biochem. 2007;19(1-4):33-42
17310098
Am J Physiol Cell Physiol. 2000 Dec;279(6):C1787-94
11078693
Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G838-43
16798725
Am J Physiol Cell Physiol. 2001 Jun;280(6):C1599-606
11350755
Pflugers Arch. 2009 Jan;457(3):609-22
18536934
J Biol Chem. 2010 Jun 11;285(24):18769-80
20360010
Endocrinology. 2008 Feb;149(2):498-505
17974627
Gastroenterology. 2003 Dec;125(6):1774-84
14724830
Mol Biol Rep. 2010 Mar;37(3):1329-33
19306073
J Biol Chem. 1990 Jun 5;265(16):9027-32
2160952
Clin Gastroenterol Hepatol. 2007 Dec;5(12):1385-91
17950677
J Clin Invest. 2000 Jun;105(12):1741-9
10862789
Am J Physiol Cell Physiol. 2005 Aug;289(2):C493-505
15800055
J Cell Sci. 2002 Mar 15;115(Pt 6):1251-8
11884524
Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15
7690557
J Physiol. 2002 Dec 15;545(3):751-66
12482884
Biochim Biophys Acta. 1996 Apr 24;1311(2):133-42
8630331
J Biol Chem. 1985 Jun 25;260(12):7540-50
2987257
Toxicol Pathol. 2008 Jul;36(5):727-37
18648100
J Biol Chem. 2006 Aug 18;281(33):23740-7
16754665
Biochim Biophys Acta. 1986 Aug 29;888(1):116-25
3741886
Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G1093-103
12736153
Am J Respir Cell Mol Biol. 1995 Jun;12(6):597-604
7766424
Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G37-G44
18483181
Hum Mol Genet. 1995 Mar;4(3):407-13
7795595
J Physiol. 2007 Oct 1;584(Pt 1):333-45
17673510
Cell Physiol Biochem. 2010;25(2-3):195-202
20110680
Am J Physiol. 1995 Jan;268(1 Pt 1):C191-200
7840147
Ann N Y Acad Sci. 2003 Apr;986:1-8
12763767
Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G664-9
15961860
Annu Rev Physiol. 2003;65:103-31
12500969
Cell Physiol Biochem. 2007;19(1-4):21-32
17310097
Gastroenterology. 1999 Jan;116(1):118-26
9869609
J Biol Chem. 2007 Mar 2;282(9):6068-74
17178714
Nature. 2007 Dec 13;450(7172):1036-42
18075584
J Biol Chem. 2000 Mar 24;275(12):8324-30
10722662
J Cell Biol. 2005 Apr 11;169(1):21-8
15809309
J Gen Physiol. 2009 Apr;133(4):421-38
19289574
J Biol Chem. 1987 Oct 15;262(29):14190-6
2888765
Nature. 2002 Aug 8;418(6898):605-11
12167852
EMBO J. 2009 Jun 3;28(11):1637-43
19387495
Biochemistry. 2007 May 8;46(18):5398-417
17425287
Nat Genet. 1996 Jan;12(1):17-23
8528244
Nat Rev Mol Cell Biol. 2006 Jun;7(6):426-36
16723978
J Clin Invest. 1994 Jan;93(1):347-54
7506713
Am J Physiol Cell Physiol. 2003 Oct;285(4):C968-76
12773316
Am J Physiol Cell Physiol. 2004 Mar;286(3):C495-506
14602583
Gastroenterology. 2008 Apr;134(4):1058-69
18395087
J Physiol. 2009 Aug 1;587(Pt 15):3955-65
19491250
J Biol Chem. 2000 Apr 14;275(15):11164-73
10753923
Gastroenterology. 1997 Jan;112(1):280-6
8978369
J Physiol. 2006 Jul 1;574(Pt 1):7-15
16644800