title: Four new sesquiterpenoids from the roots of Incarvillea arguta and their inhibitory activities against lipopolysaccharide-induced nitric oxide production.
abstract: Four new sesquiterpenoids, argutosines A-D (1-4), together with two known ones (5, 6), were isolated from the roots of Incarvillea arguta. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analysis. All the sesquiterpenoids were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Argutosines A, B and C (1-3) showed potent inhibitory activities with IC(50) values of 2.05, 0.55, and 9.87 microM, respectively.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide