title: Effect of dihydrocapsiate on resting metabolic rate in humans.
abstract: BACKGROUND
  Dihydrocapsiate is a capsinoid found in chili peppers. Dihydrocapsiate is similar to capsaicin, which is known for its thermogenic properties.
  
  
  OBJECTIVE
  The objective was to determine the acute and chronic effect of dihydrocapsiate on resting metabolic rate (RMR).
  
  
  METHODS
  Seventy-eight healthy subjects in a double-blind, parallel-arm trial were randomly assigned to 3 groups receiving 0 (placebo), 3, or 9 mg dihydrocapsiate/d for 28 d. After a 10-h overnight fast, RMR was measured by indirect calorimetry for 30 min before and 120 min after ingestion of dihydrocapsiate.
  
  
  RESULTS
  RMR was similar in the 3 groups before dosing on day 1 [1714 ± 41 kcal/d (0 mg), 1760 ± 41 kcal/d (3 mg), and 1694 ± 38 kcal/d (9 mg)] and after acute dosing (41 ± 17, 55 ± 17, and 3 ± 24 kcal/d for 3-mg, 9-mg, and placebo groups, respectively). When the chronic effect of dihydrocapsiate on RMR was calculated from the average 2-h RMR on day 28 minus the 30-min preingestion RMR at baseline, a borderline effect in subjects receiving 3 mg dihydrocapsiate/d compared with placebo was observed (61 ± 24 kcal/d compared with -1 ± 12 kcal/d, P = 0.054), whereas no significant increase in RMR in comparison with placebo was noted for the 9-mg/d dose (48 ± 23 kcal/d compared with -1 ± 12 kcal/d, P = 0.12). When data from both groups were combined, the thermic effect of dihydrocapsiate reached significance (53 ± 9 kcal/d compared with -1 ± 12 kcal/d in the placebo group, P = 0.04). Fat oxidation was unaffected by dihydrocapsiate.
  
  
  CONCLUSIONS
  After 1 mo of supplementation, dihydrocapsiate had a small thermogenic effect of ≈50 kcal/d, which is in the range of day-to-day RMR variability. This trial was registered at clinicaltrials.gov as NCT00999297.
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors.forename: Jose E
authors.initials: JE
authors.lastname: Galgani
authors.forename: Eric
authors.initials: E
authors.lastname: Ravussin
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001481:Basal Metabolism / Q000187:drug effects*; D002211:Capsaicin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002212:Capsicum / Q000737:chemistry*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D012016:Reference Values; D022722:Thermogenesis / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts; D002211:Capsaicin
references.citation: Biosci Biotechnol Biochem. 2001 Dec;65(12):2735-40
references.pmid: 11826971
references.citation: Br J Nutr. 2003 Aug;90(2):419-23
references.pmid: 12908903
references.citation: Int J Obes. 1987;11(3):239-49
references.pmid: 3667060
references.citation: Neuropharmacology. 2003 Jun;44(7):958-67
references.pmid: 12726827
references.citation: Science. 2003 Aug 1;301(5633):598; author reply 598
references.pmid: 12893926
references.citation: Int J Obes (Lond). 2008 Dec;32 Suppl 7:S109-19
references.pmid: 19136979
references.citation: Biochem Biophys Res Commun. 1987 Jan 15;142(1):259-64
references.pmid: 3814133
references.citation: Public Health Nutr. 2005 Oct;8(7A):994-1009
references.pmid: 16277816
references.citation: Br J Nutr. 2010 Jan;103(1):38-42
references.pmid: 19671203
references.citation: Am J Clin Nutr. 2006 Apr;83(4):859-63
references.pmid: 16600939
references.citation: Proc Soc Exp Biol Med. 1986 Nov;183(2):250-6
references.pmid: 2876434
references.citation: N Engl J Med. 2009 Apr 9;360(15):1518-25
references.pmid: 19357407
references.citation: Br J Nutr. 2003 Sep;90(3):651-59
references.pmid: 13129472
references.citation: Biosci Biotechnol Biochem. 2007 Feb;71(2):380-9
references.pmid: 17284861
references.citation: J Clin Invest. 1986 Dec;78(6):1568-78
references.pmid: 3782471
references.citation: Proc Soc Exp Biol Med. 1988 Jun;188(2):229-33
references.pmid: 3375268
references.citation: J Clin Endocrinol Metab. 1992 Jul;75(1):15-20
references.pmid: 1320047
references.citation: J Clin Invest. 1993 Jan;91(1):344-9
references.pmid: 8380813
references.citation: Am J Clin Nutr. 2009 Jan;89(1):45-50
references.pmid: 19056576
references.citation: Annu Rev Nutr. 1987;7:187-208
references.pmid: 3300732
references.citation: Am J Physiol. 1988 Jul;255(1 Pt 1):E23-7
references.pmid: 2898892
references.citation: Public Health Nutr. 2004 Feb;7(1A):245-50
references.pmid: 14972063
references.citation: N Engl J Med. 2009 Apr 9;360(15):1500-8
references.pmid: 19357405
references.citation: Biosci Biotechnol Biochem. 2010;74(2):274-8
references.pmid: 20139632
references.citation: J Nat Prod. 1999 Feb;62(2):335-6
references.pmid: 10075779
references.citation: Endocr Rev. 2006 Dec;27(7):750-61
references.pmid: 17122359
references.citation: N Engl J Med. 2009 Apr 9;360(15):1509-17
references.pmid: 19357406
references.citation: J Appl Physiol (1985). 2003 Dec;95(6):2408-15
references.pmid: 12959953
references.citation: Int J Obes Relat Metab Disord. 1993 Dec;17(12):693-700
references.pmid: 8118473