title: The effect of safranal on histamine (H(1)) receptors of guinea pig tracheal chains.
abstract: The effect of three concentrations of safranal on histamine (H(1)) receptors was tested on two groups of tracheal chains incubated with: 1) indomethacin, and 2) indomethacin, propranolol and atropine (n = 6). The EC(50) (effective concentration of histamine causing 50% of maximum response) obtained in the presence of chlorpheniramine and all concentrations of safranal in both groups were significantly greater than those of saline (p < 0.05 to p < 0.001). The EC(50) obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 μg/mL) in group 2 were greater than in group 1 (p < 0.05 to p < 0.001).
authors.affiliation: Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran. boskabadymh@mums.ac.ir
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Boskabady
authors.forename: Mahbobaeh Ghasemzadeh
authors.initials: MG
authors.lastname: Rahbardar
authors.forename: Zahra
authors.initials: Z
authors.lastname: Jafari
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002744:Chlorpheniramine / Q000494:pharmacology; D027622:Crocus / Q000737:chemistry*; D053138:Cyclohexenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D035264:Flowers; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000378:metabolism; D013729:Terpenes / Q000494:pharmacology*; D014132:Trachea
chemical_list: D053138:Cyclohexenes; D006634:Histamine H1 Antagonists; D010936:Plant Extracts; D011943:Receptors, Adrenergic, beta; D011969:Receptors, Histamine H1; D011976:Receptors, Muscarinic; D013729:Terpenes; D002744:Chlorpheniramine; C087963:safranal; D001285:Atropine; D006632:Histamine; D011433:Propranolol; D007213:Indomethacin