title: Inhibitory effects of acylated acyclic sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor-alpha-induced cytotoxicity.
abstract: Four new acylated acyclic sesquiterpene oligoglycosides (1-4) were isolated from the pericarps of Sapindus rarak DC. together with four known acyclic sesquiterpene oligoglycosides, mukuroziosides Ia (5), Ib (6), IIa (7), and IIb (8). Their structures were elucidated on the basis of chemical and physicochemical evidence. These newly isolated compounds (1-4) were found to show inhibitory effects on tumor necrosis factor-alpha-induced cytotoxicity in L929 cells at concentrations of 30-100 microM.
authors.affiliation: Pharmaceutical Research and Technology Institute, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xie
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Masaki
authors.initials: M
authors.lastname: Okamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
authors.forename: Dan
authors.initials: D
authors.lastname: Yuan
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Takao
authors.initials: T
authors.lastname: Hayakawa
mesh_terms: D000215:Acylation; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D032127:Sapindus / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D003603:Cytotoxins; D006027:Glycosides; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha