Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis.
OBJECTIVE
To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis.


METHODS
We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for genotypes GG/T vs T/T, GG/GG vs T/T, GG/T + GG/GG vs T/T, GG/GG vs T/T + GG/T, and GG allele vs T allele in a fixed/random effect model.


RESULTS
We identified 8 studies (6439 cases and 4798 controls) in Caucasian populations using PubMed search. We found no association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Stratification of cases by age showed that NOD1/CARD4 insertion/deletion polymorphism was associated with inflammatory bowel disease in younger age group at onset (< 40 years) (GG vs T: OR = 0.68, 95% CI: 0.50-0.93, P = 0.02; GG/T + GG/GG vs T/T: OR = 0.71, 95% CI: 0.59-0.85, P = 0.0003).


CONCLUSIONS
This meta-analysis demonstrates an association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease in the younger age group at onset (< 40 years) in Caucasian populations.
Lu
Wei-Guo
WG
Department of Clinical Pharmacology, The Third Hospital Affiliated to Nantong University, Wuxi 214041, Jiangsu Province, China.
Zou
Yan-Feng
YF
Feng
Xiao-Liang
XL
Yuan
Feng-Lai
FL
Gu
Yuan-Long
YL
Li
Xia
X
Li
Cheng-Wan
CW
Jin
Cheng
C
Li
Jian-Ping
JP
D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D016254:Mutagenesis, Insertional; D053474:Nod1 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic
C119067:NOD1 protein, human; D053474:Nod1 Signaling Adaptor Protein
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