title: Rechallenging with anthracyclines and taxanes in metastatic breast cancer.
abstract: Adjuvant use of anthracycline-taxane combination therapy is an accepted strategy in the management of high-risk early-stage breast cancer. However, the introduction of this regimen raises the question of how best to manage those patients who relapse following adjuvant therapy, and whether there is a role for rechallenging in the metastatic setting with the same agent, or class of agent, that has been utilized in the adjuvant setting. This Review examines the evidence for rechallenging with both anthracyclines and taxanes, and highlights the issues that need to be examined in the context of future clinical trials.
authors.affiliation: Cancer Research UK Laboratories, Department of Oncology, MRC Cyclotron Building, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 ONN, UK. c.palmieri@imperial.ac.uk
authors.forename: Carlo
authors.initials: C
authors.lastname: Palmieri
authors.forename: Jonathan
authors.initials: J
authors.lastname: Krell
authors.forename: Colin R
authors.initials: CR
authors.lastname: James
authors.forename: Catherine
authors.initials: C
authors.lastname: Harper-Wynne
authors.forename: Vivek
authors.initials: V
authors.lastname: Misra
authors.forename: Susan
authors.initials: S
authors.lastname: Cleator
authors.forename: David
authors.initials: D
authors.lastname: Miles
mesh_terms: D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy; D019233:Retreatment; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D018943:Anthracyclines; D043823:Taxoids
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