title: A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.
abstract: The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saitoh
authors.forename: Chika
authors.initials: C
authors.lastname: Shimada
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeiri
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Shiino
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ohba
authors.forename: Rika
authors.initials: R
authors.lastname: Obata
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishiyama
mesh_terms: D000818:Animals; D001549:Benzamides / Q000737:chemistry*; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006873:Hydroquinones / Q000737:chemistry*; D051379:Mice; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001549:Benzamides; D003512:Cyclohexanones; D004852:Epoxy Compounds; D006873:Hydroquinones; D016328:NF-kappa B; C464444:dehydroxymethylepoxyquinomicin; D009569:Nitric Oxide