title: Genetic liability, environment, and the development of fussiness in toddlers: the roles of maternal depression and parental responsiveness.
abstract: Using a longitudinal, prospective adoption design, the authors of this study examined the effects of the environment (adoptive parents' depressive symptoms and responsiveness) and genetic liability of maternal depression (inferred by birth mothers' major depressive disorder [MDD]) on the development of fussiness in adopted children between 9 and 18 months old. The sample included 281 families linked through adoption, with each family including 4 individuals (i.e., adopted child, birth mother, adoptive father and mother). Results showed that adoptive mothers' depressive symptoms when their child was 9 months old were positively associated with child fussiness at 18 months. A significant interaction between birth mothers' MDD and adoptive mothers' responsiveness indicated that children of birth mothers with MDD showed higher levels of fussiness at 18 months when adoptive mothers had been less responsive to the children at 9 months. However, in the context of high levels of adoptive mothers' responsiveness, children of birth mothers with MDD did not show elevated fussiness at 18 months. Findings are discussed in terms of gene-environment interactions in the intergenerational risk transmission of depression.
authors.affiliation: Department of Psychology, University of California, Riverside, 900 University Ave., Riverside, CA 92521, USA. misaki.natsuaki@ucr.edu
authors.forename: Misaki N
authors.initials: MN
authors.lastname: Natsuaki
authors.forename: Xiaojia
authors.initials: X
authors.lastname: Ge
authors.forename: Leslie D
authors.initials: LD
authors.lastname: Leve
authors.forename: Jenae M
authors.initials: JM
authors.lastname: Neiderhiser
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Shaw
authors.forename: Rand D
authors.initials: RD
authors.lastname: Conger
authors.forename: Laura V
authors.initials: LV
authors.lastname: Scaramella
authors.forename: John B
authors.initials: JB
authors.lastname: Reid
authors.forename: David
authors.initials: D
authors.lastname: Reiss
mesh_terms: D000300:Adoption / Q000523:psychology; D000367:Age Factors; D016241:Child of Impaired Parents; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology*; D004777:Environment; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008960:Models, Psychological; D010287:Parent-Child Relations; D016487:Parenting; D011247:Pregnancy
references.citation: Dev Psychopathol. 1998 Spring;10(2):283-300
references.pmid: 9635225
references.citation: J Pers Soc Psychol. 1989 Mar;56(3):317-25
references.pmid: 2926632
references.citation: J Gerontol B Psychol Sci Soc Sci. 2005 Mar;60 Spec No 1:65-76
references.pmid: 15863711
references.citation: Pediatrics. 1998 Nov;102(5 Suppl E):1298-304
references.pmid: 9794973
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17316-21
references.pmid: 15563601
references.citation: Arch Gen Psychiatry. 2005 Feb;62(2):173-81
references.pmid: 15699294
references.citation: Psychol Bull. 2001 May;127(3):291-324
references.pmid: 11393298
references.citation: Dev Psychopathol. 2006 Winter;18(1):17-34
references.pmid: 16478550
references.citation: Br J Psychiatry. 2001 Aug;179:116-21
references.pmid: 11483472
references.citation: Br J Psychiatry. 1989 Sep;155:294-304
references.pmid: 2692760
references.citation: Twin Res Hum Genet. 2007 Feb;10(1):84-95
references.pmid: 17539368
references.citation: Clin Psychol Rev. 2004 Jul;24(3):339-60
references.pmid: 15245835
references.citation: Psychol Rev. 1999 Jul;106(3):458-90
references.pmid: 10467895
references.citation: Psychol Bull. 1990 Jul;108(1):50-76
references.pmid: 2200073
references.citation: Am J Psychiatry. 2008 Sep;165(9):1148-54
references.pmid: 18558644
references.citation: Dev Psychol. 1999 Jan;35(1):223-31
references.pmid: 9923477
references.citation: J Child Psychol Psychiatry. 1997 Jan;38(1):81-99
references.pmid: 9232459
references.citation: Twin Res Hum Genet. 2005 Aug;8(4):328-36
references.pmid: 16176717
references.citation: J Fam Psychol. 2008 Aug;22(4):529-40
references.pmid: 18729667
references.citation: Psychol Rev. 1998 Oct;105(4):792-802
references.pmid: 9830380
references.citation: Dev Psychopathol. 2007 Fall;19(4):1073-87
references.pmid: 17931435
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):543-9
references.pmid: 17987668
references.citation: Dev Psychol. 2007 Jan;43(1):222-37
references.pmid: 17201521
references.citation: J Am Acad Child Adolesc Psychiatry. 2006 Jul;45(7):841-8
references.pmid: 16832321
references.citation: Br J Psychiatry. 2002 Jun;180:502-8
references.pmid: 12042228
references.citation: Child Dev. 1988 Aug;59(4):852-67
references.pmid: 3168624
references.citation: Annu Rev Psychol. 2003;54:205-28
references.pmid: 12172001
references.citation: Psychol Bull. 1992 May;111(3):387-412
references.pmid: 1594718
references.citation: Dev Psychol. 1999 Mar;35(2):569-79
references.pmid: 10082027
references.citation: Am J Psychiatry. 1995 Jun;152(6):833-42
references.pmid: 7755111
references.citation: Dev Sci. 2007 Jan;10(1):1-11
references.pmid: 17181692
references.citation: Biol Psychiatry. 2005 Aug 1;58(3):211-7
references.pmid: 16084841
references.citation: Science. 2003 Jul 18;301(5631):386-9
references.pmid: 12869766
references.citation: Dev Psychopathol. 2009 Spring;21(2):417-39
references.pmid: 19338691
references.citation: New Dir Child Dev. 1989 Spring;(43):49-61
references.pmid: 2710392
references.citation: J Child Psychol Psychiatry. 1991 May;32(4):609-26
references.pmid: 1864892
references.citation: Int J Methods Psychiatr Res. 2004;13(2):93-121
references.pmid: 15297906
references.citation: Arch Gen Psychiatry. 2005 May;62(5):473-81
references.pmid: 15867100
references.citation: Dev Psychol. 1997 Nov;33(6):1040-53
references.pmid: 9383626
references.citation: Dev Psychol. 2006 Jul;42(4):627-42
references.pmid: 16802896
references.citation: Biol Psychiatry. 2008 Feb 15;63(4):406-14
references.pmid: 17698041
references.citation: Monogr Soc Res Child Dev. 1985;50(1-2):167-93
references.pmid: 4069127
references.citation: Child Dev. 1979 Sep;50(3):794-803
references.pmid: 498854
references.citation: Child Dev. 1995 Dec;66(6):1798-816
references.pmid: 8556900
references.citation: J Child Psychol Psychiatry. 2008 Dec;49(12):1313-20
references.pmid: 19120710
references.citation: Am J Psychiatry. 2003 Sep;160(9):1566-77
references.pmid: 12944328
references.citation: Child Dev. 2010 Jan-Feb;81(1):340-56
references.pmid: 20331671
references.citation: J Am Acad Child Adolesc Psychiatry. 1993 Mar;32(2):287-90
references.pmid: 8444756
references.citation: Dev Psychol. 2001 May;37(3):387-403
references.pmid: 11370914
references.citation: Br J Clin Psychol. 1995 Feb;34(1):17-36
references.pmid: 7757037
references.citation: J Child Psychol Psychiatry. 2003 Oct;44(7):1006-14
references.pmid: 14531583
references.citation: J Abnorm Child Psychol. 1998 Apr;26(2):95-107
references.pmid: 9634132
references.citation: Soc Psychiatry Psychiatr Epidemiol. 1998 Feb;33(2):80-8
references.pmid: 9503991
references.citation: J Fam Psychol. 2001 Mar;15(1):38-52
references.pmid: 11322084
references.citation: Child Dev. 1995 Feb;66(1):55-68
references.pmid: 7497829