title: Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment.
abstract: A long-term experimental animal model was developed by our research group for the evaluation of potential chemopreventive effects. The inhibitory effects of agents on carcinogen (7,12-dimethylbenz[a]anthracene (DMBA) induced molecular epidemiological biomarkers, in this case the expression of key onco/suppressor genes were investigated. The expression pattern of c-myc, Ha-ras, Bcl-2, K-ras protooncogene and p53 tumour suppressor gene were studied to elucidate early carcinogenic and potential chemopreventive effects. The consumption of so-called Claw of Dragon tea (CoD™ tea) containing the bark of Uncaria guianensis, Cat's Claw (Uncaria sp. U. tomentosa) and Palmer trumpet-tree (Tabebuia sp. T. avellanedae) was able to decrease the DMBA-induced onco/suppressor gene overexpression in a short-term animal experiment. In a following study CBA/Ca mice were treated with 20 mg/kg bw DMBA intraperitoneally (i.p.) and the expression patterns of onco/suppressor genes were examined at several time intervals. According to the examined gene expression patterns in this long-term experiment the chemopreventive effect of CoD™ tea consumption could be confirmed.
authors.affiliation: Institute of Public Health, Medical School, University of Pécs, Szigeti str. 12, H-7643 Pécs, Hungary. budfer2@gmail.com
authors.forename: Ferenc
authors.initials: F
authors.lastname: Budán
authors.forename: István
authors.initials: I
authors.lastname: Szabó
authors.forename: Tímea
authors.initials: T
authors.lastname: Varjas
authors.forename: Ghodratollah
authors.initials: G
authors.lastname: Nowrasteh
authors.forename: Tamás
authors.initials: T
authors.lastname: Dávid
authors.forename: Péter
authors.initials: P
authors.lastname: Gergely
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Varga
authors.forename: Kornélia
authors.initials: K
authors.lastname: Molnár
authors.forename: Balázs
authors.initials: B
authors.lastname: Kádár
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Orsós
authors.forename: István
authors.initials: I
authors.lastname: Kiss
authors.forename: István
authors.initials: I
authors.lastname: Ember
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000494:pharmacology*; D029663:Tabebuia / Q000737:chemistry*; D032070:Uncaria / Q000737:chemistry*
chemical_list: D016588:Anticarcinogenic Agents; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene