[Usefulness of endothelin-1 determinations in the diagnosis of cardiovascular diseases].
Factor involved in the pathogenesis of cardiovascular diseases, especially coronary heart disease is the endothelium. The balance between endothelial substances originating from the action, and narrowed the extension is the essence of vascular hemostasis. The main dish is shrinking substances endothelin-1 (ET-1). The aim of the study was to determine the role of signs ET-1 levels in the diagnosis of cardiovascular diseases, especially coronary heart disease. In numerous reports described the impact of increased blood pressure, caused by the press on blood vessels. Most authors reported higher concentrations of ET-1 in serum of patients with ischemic heart disease, particularly its unstable character. High values were observed in patients with myocardial infarction. ET-1 level in the blood is markedly increased in patients with heart failure, correlating with NYHA functional class. High concentrations of ET-1 in many disease entities, and thus its low specificity makes the need for further research on the importance of this substance in the diagnosis of cardiovascular diseases.
Celiński
Rafał
R
Uniwersytet Rzeszowski, Instytut Fizjoterapii.
D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis*; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis; D019332:Endothelin-1 / Q000097:blood*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis; D012680:Sensitivity and Specificity
D015415:Biomarkers; D019332:Endothelin-1