title: Association study of interferon-γ, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease.
abstract: OBJECTIVE
  The increased production of proinflammatory mediators such as cytokines and prostaglandins may interact at multiple levels with neurodegeneration in Alzheimer disease (AD). This study was undertaken to evaluate the possible role of interferon-γ (IFN-γ) T+874A, cytoplasmic phospholipase A₂ (cPLA2) BanI, and cyclooxygenase-2 (COX-2) G-765C polymorphisms in AD.
  
  
  METHODS
  The study included 237 probable patients with AD who met the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-AD and Related Disorders Association, and 245 probands in the healthy comparison (HC) group.
  
  
  RESULTS
  No significant difference in mean age or in the distribution of genders between AD and HC groups was found. The COX-2 G/G genotype was significantly more frequent in the AD, when compared with the HC group. There was no significant correlation between IFN-γ or cPLA2 genotypes and AD.
  
  
  CONCLUSIONS
  Our findings indicate that the COX-2 G/G genotype is associated with AD and support the involvement of COX-2 in AD etiology.
authors.affiliation: Department of Psychiatry, University of Szeged, Hungary. fehera@nepsy.szote.u-szeged.hu
authors.forename: Agnes
authors.initials: A
authors.lastname: Fehér
authors.forename: Anna
authors.initials: A
authors.lastname: Juhász
authors.forename: Agnes
authors.initials: A
authors.lastname: Rimanóczy
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Janka
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015577:Geriatric Assessment; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D054510:Phospholipases A2, Cytosolic / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007371:Interferon-gamma; D051546:Cyclooxygenase 2; D054510:Phospholipases A2, Cytosolic