MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting.
The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.
De León-Rodríguez
Luis M
LM
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA.
Lubag
Angelo
A
Udugamasooriya
D Gomika
DG
Proneth
Bettina
B
Brekken
Rolf A
RA
Sun
Xiankai
X
Kodadek
Thomas
T
Dean Sherry
A
A
D000818:Animals; D000873:Anthracenes / Q000737:chemistry*; D045744:Cell Line, Tumor; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D008970:Molecular Weight; D034444:Peptoids / Q000737:chemistry* / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
D000873:Anthracenes; D034444:Peptoids; C501244:dendron; D005682:Gadolinium; D040301:Vascular Endothelial Growth Factor Receptor-2
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