title: Standardization of relative cerebral blood volume (rCBV) image maps for ease of both inter- and intrapatient comparisons.
abstract: Relative cerebral blood volume (rCBV) measured using dynamic susceptibility contrast MRI suffers from interpatient and interstudy variability for the same tissue type. Traditionally, when a more quantitative assessment of rCBV is required, as for comparison across studies and patients, the rCBV values are normalized to the rCBV in a reference region such as normal-appearing white matter. However, this technique of normalization is subjective and time consuming and introduces user-dependent variability. In this study, we demonstrate that a method called standardization, applied to rCBV maps, is an objective means of translating all rCBV values to a consistent scale. This approach reduces interpatient and interstudy variability for the same tissue type, thus enabling easy and accurate visual and quantitative comparison across studies. One caveat to this approach is that it is not appropriate for the evaluation of global changes in blood volume, since systematic differences are removed in the process of standardization.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
authors.forename: Devyani
authors.initials: D
authors.lastname: Bedekar
authors.forename: Todd
authors.initials: T
authors.lastname: Jensen
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Schmainda
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001810:Blood Volume / Q000502:physiology*; D001811:Blood Volume Determination / Q000379:methods*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
references.citation: Top Magn Reson Imaging. 1999 Apr;10(2):114-24
references.pmid: 10551626
references.citation: Radiology. 2008 Nov;249(2):601-13
references.pmid: 18780827
references.citation: J Magn Reson Imaging. 2005 May;21(5):512-9
references.pmid: 15834910
references.citation: Magn Reson Med. 1999 Dec;42(6):1072-81
references.pmid: 10571928
references.citation: Radiology. 2002 Mar;222(3):715-21
references.pmid: 11867790
references.citation: Magn Reson Med. 2000 Jun;43(6):845-53
references.pmid: 10861879
references.citation: AJNR Am J Neuroradiol. 2006 Apr;27(4):859-67
references.pmid: 16611779
references.citation: Radiology. 2006 Feb;238(2):658-67
references.pmid: 16396838
references.citation: AJNR Am J Neuroradiol. 2004 Oct;25(9):1524-32
references.pmid: 15502131
references.citation: AJNR Am J Neuroradiol. 2003 Nov-Dec;24(10):1989-98
references.pmid: 14625221
references.citation: Magn Reson Med. 2006 Mar;55(3):514-23
references.pmid: 16463343
references.citation: Med Phys. 2006 Sep;33(9):3426-34
references.pmid: 17022239
references.citation: Cancer Cell. 2007 Jan;11(1):83-95
references.pmid: 17222792
references.citation: AJNR Am J Neuroradiol. 2000 May;21(5):881-90
references.pmid: 10815664
references.citation: Clin Cancer Res. 2000 Jun;6(6):2189-200
references.pmid: 10873068
references.citation: AJNR Am J Neuroradiol. 2000 May;21(5):901-9
references.pmid: 10815666
references.citation: IEEE Trans Med Imaging. 2000 Feb;19(2):143-50
references.pmid: 10784285
references.citation: Magn Reson Med. 2003 May;49(5):848-55
references.pmid: 12704767