Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats.
Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes' anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic-like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury.
Mahesh
Radhakrishnan
R
Department of Pharmacy, FD-III, Birla Institute of Technology & Science, Pilani 333 031, India.
Pandey
Dilip Kumar
DK
Katiyar
Shruti
S
Kukade
Gaurav
G
Viyogi
Shruti
S
Rudra
Anjuman
A
D000054:Acceleration / Q000009:adverse effects*; D000639:Amitriptyline / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology; D001522:Behavior, Animal / Q000187:drug effects*; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D016642:Bupropion / Q000494:pharmacology / Q000627:therapeutic use; D015283:Citalopram / Q000494:pharmacology / Q000627:therapeutic use; D003511:Cyclohexanols / Q000494:pharmacology / Q000627:therapeutic use; D005106:Exploratory Behavior / Q000187:drug effects; D005239:Fear / Q000187:drug effects; D008297:Male; D009473:Neuronal Plasticity; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D012919:Social Behavior; D000069470:Venlafaxine Hydrochloride
D000928:Antidepressive Agents; D003511:Cyclohexanols; D014179:Neurotransmitter Uptake Inhibitors; D016642:Bupropion; D015283:Citalopram; D000639:Amitriptyline; D012701:Serotonin; D000069470:Venlafaxine Hydrochloride; D009638:Norepinephrine