Direct C-H arylation of electron-deficient heterocycles with arylboronic acids.
A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.
Seiple
Ian B
IB
Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Su
Shun
S
Rodriguez
Rodrigo A
RA
Gianatassio
Ryan
R
Fujiwara
Yuta
Y
Sobel
Adam L
AL
Baran
Phil S
PS
D001897:Boronic Acids / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*
D001897:Boronic Acids; D006571:Heterocyclic Compounds; D002244:Carbon; D006859:Hydrogen
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