title: Age- and gender-related changes in contractile properties of non-atrophied EDL muscle.
abstract: BACKGROUND
  In humans, ageing causes skeletal muscles to become atrophied, weak, and easily fatigued. In rodent studies, ageing has been associated with significant muscle atrophy and changes in the contractile properties of the muscles. However, it is not entirely clear whether these changes in contractile properties can occur before there is significant atrophy, and whether males and females are affected differently.
  
  
  RESULTS
  We investigated various contractile properties of whole isolated fast-twitch EDL muscles from adult (2-6 months-old) and aged (12-22 months-old) male and female mice. Atrophy was not present in the aged mice. Compared with adult mice, EDL muscles of aged mice had significantly lower specific force, longer tetanus relaxation times, and lower fatiguability. In the properties of absolute force and muscle relaxation times, females were affected by ageing to a greater extent than males. Additionally, EDL muscles from a separate group of male mice were subjected to eccentric contractions of 15% strain, and larger force deficits were found in aged than in adult mice.
  
  
  CONCLUSIONS
  Our findings provide further insight into the muscle atrophy, weakness and fatiguability experienced by the elderly. We have shown that even in the absence of muscle atrophy, there are definite alterations in the physiological properties of whole fast-twitch muscle from ageing mice, and for some of these properties the alterations are more pronounced in female mice than in male mice.
authors.affiliation: School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Chan
authors.forename: Stewart I
authors.initials: SI
authors.lastname: Head
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D006728:Hormones / Q000378:metabolism; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism / Q000502:physiology*; D009126:Muscle Relaxation / Q000502:physiology; D009133:Muscular Atrophy / Q000378:metabolism / Q000503:physiopathology*; D012727:Sex Characteristics
chemical_list: D006728:Hormones
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