title: Octreotide in the treatment of neonatal postoperative chylothorax: report of three cases and literature review.
abstract: Chylothorax is a well-recognized complication after neonatal cardiothoracic surgery. Management strategies include cessation of enteral feedings, repeated aspiration, chest drainage, and total parenteral nutrition. Somatostatin and its analogue, octreotide, have been used with promising results. The authors present three cases of neonatal postoperative chylothorax in which octreotide was used. After literature review, we can say that octreotide is relatively safe, and may reduce clinical course and complications associated with neonatal postoperative chylothorax. One should be aware of possible association between octreotide and necrotizing enterocolitis. Prospective controlled trials supporting octreotide use are lacking.
authors.affiliation: Serviço de Cirurgia Pediátrica, Centro Hospitalar do Porto, Rua da Boavista, 827, 4050-111, Porto, Portugal. moreirapinto@gmail.com
authors.forename: João
authors.initials: J
authors.lastname: Moreira-Pinto
authors.forename: Paula
authors.initials: P
authors.lastname: Rocha
authors.forename: Angélica
authors.initials: A
authors.lastname: Osório
authors.forename: Berta
authors.initials: B
authors.lastname: Bonet
authors.forename: Fátima
authors.initials: F
authors.lastname: Carvalho
authors.forename: Carlos
authors.initials: C
authors.lastname: Duarte
authors.forename: Luísa
authors.initials: L
authors.lastname: Oliveira
mesh_terms: D002916:Chylothorax / Q000209:etiology / Q000628:therapy*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004322:Drainage / Q000379:methods*; D004933:Esophageal Atresia / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D015282:Octreotide / Q000008:administration & dosage*
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide
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