Apoptosis: embedded in membranes.
Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.
Bogner
Christian
C
Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Room 4H-41, Hamilton, Ontario, Canada L8N 3Z5.
Leber
Brian
B
Andrews
David W
DW
D017209:Apoptosis / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D020836:Protein Structure, Quaternary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051020:bcl-X Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein