Sensitivity of CFD based hemodynamic results in rabbit aneurysm models to idealizations in surrounding vasculature.
Computational fluid dynamics (CFD) studies provide a valuable tool for evaluating the role of hemodynamics in vascular diseases such as cerebral aneurysms and atherosclerosis. However, such models necessarily only include isolated segments of the vasculature. In this work, we evaluate the influence of geometric approximations in vascular anatomy on hemodynamics in elastase induced saccular aneurysms in rabbits. One representative high aspect ratio (AR-height/neck width) aneurysm and one low AR aneurysm were created at the origin of the right common carotid artery in two New Zealand white rabbits. Three-dimensional (3D) reconstructions of the aneurysm and surrounding arteries were created using 3D rotational angiographic data. Five models with varying extents of neighboring vasculature were created for both the high and low AR cases. A reference model included the aneurysm sac, left common carotid artery (LCCA), aortic arch, and downstream trifurcation/quadrification. Three-dimensional, pulsatile CFD studies were performed and streamlines, wall shear stress (WSS), oscillatory shear index, and cross sectional velocity were compared between the models. The influence of the vascular domain on intra-aneurysmal hemodynamics varied between the low and high AR cases. For the high AR case, even a simple model including only the aneurysm, a small section of neighboring vasculature, and simple extensions captured the main features of the steamline and WSS distribution predicted by the reference model. However, the WSS distribution in the low AR case was more strongly influenced by the extent of vasculature. In particular, it was necessary to include the downstream quadrification and upstream LCCA to obtain good predictions of WSS. The findings in this work demonstrate the accuracy of CFD results can be compromised if insufficient neighboring vessels are included in studies of hemodynamics in elastase induced rabbit aneurysms. Consideration of aspect ratio, hemodynamic parameters of interest, and acceptable magnitude of error when selecting the vascular domain will increase reliability of the results while decreasing computational time.
Zeng
Zijing
Z
Department of Mechanical Engineering and Materials Science, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA. ziz3@pitt.edu
Kallmes
David F
DF
Durka
Michael J
MJ
Ding
Yonghong
Y
Lewis
Debra
D
Kadirvel
Ramanathan
R
Robertson
Anne M
AM
D000792:Angiography; D000818:Animals; D001158:Arteries / Q000503:physiopathology; D002533:Cerebral Angiography / Q000379:methods; D003198:Computer Simulation; D006439:Hemodynamics; D057446:Hydrodynamics; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging*; D008954:Models, Biological; D011817:Rabbits; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical
J Biomech Eng. 2001 Oct;123(5):464-73
11601732
AJNR Am J Neuroradiol. 2005 Oct;26(9):2357-63
16219845
J Physiol. 1955 Mar 28;127(3):553-63
14368548
AJNR Am J Neuroradiol. 2006 Jan;27(1):139-41
16418373
Ann Biomed Eng. 2008 Sep;36(9):1515-30
18629648
AJNR Am J Neuroradiol. 2006 Sep;27(8):1703-9
16971618
J Biomech Eng. 1996 Feb;118(1):74-82
8833077
Stroke. 1997 Feb;28(2):398-403; discussion 403-4
9040697
Neurosurgery. 2001 Mar;48(3):495-502; discussion 502-3
11270538
AJNR Am J Neuroradiol. 2003 Apr;24(4):559-66
12695182
Stroke. 2007 Jun;38(6):1924-31
17495215
AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2550-9
16286400
JAMA. 1999 Dec 1;282(21):2035-42
10591386
J Neurosurg. 2003 Sep;99(3):447-51
12959428
Ann Biomed Eng. 2002 Apr;30(4):483-97
12086000
Circ Res. 1974 Feb;34(2):193-203
4272693
Am J Physiol. 1999 May;276(5):C1100-7
10329958
Neurosurgery. 2008 Mar;62(3):602-9; discussion 602-9
18301349
AJR Am J Roentgenol. 2000 Feb;174(2):349-54
10658703
Neurosurgery. 2006 Nov;59(5):1094-100; discussion 1100-1
17143243
Brain. 2001 Feb;124(Pt 2):249-78
11157554
Neurosurgery. 1999 Jul;45(1):119-29; discussion 129-30
10414574
J Gen Physiol. 1977 Apr;69(4):449-61
853286
AJNR Am J Neuroradiol. 2003 Apr;24(4):591-6
12695186
Stroke. 2009 Mar;40(3):952-8
19150864
Stroke. 1978 Nov-Dec;9(6):583-7
741491
J Neurosurg. 2005 Oct;103(4):662-80
16266049
Circulation. 2000 May 30;101(21):2532-8
10831529
J Biomech Eng. 2007 Dec;129(6):863-72
18067390
Acta Neurochir Suppl (Wien). 1990;48:1-57
2389684
Stroke. 2004 Nov;35(11):2500-5
15514200
Stroke. 1984 Sep-Oct;15(5):846-50
6474536
AJNR Am J Neuroradiol. 2007 May;28(5):864-9
17494658
Neuroradiology. 2007 Dec;49(12):1041-53
17882410
AJNR Am J Neuroradiol. 2005 Aug;26(7):1757-63
16091526
AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1833-7
11733310
AJNR Am J Neuroradiol. 2008 Sep;29(8):1566-9
18599579
J Biomech Eng. 2002 Aug;124(4):378-87
12188204