Research ethics in the era of personalized medicine: updating science's contract with society.
With the completed sequence of the human genome has come the prospect of substantially improving the quality of life for millions through personalized medicine approaches. Still, any advances in this direction require research involving human subjects. For decades science and ethics have enjoyed an allegiance reflected in a common set of ethical principles and procedures guiding the conduct of research with human subjects. Some of these principles emphasize avoiding harm over maximizing benefit. In this paper we revisit the priority given to these ethical principles - particularly the principles that support a cautious approach to science - and propose a reframing of the 'social contract' between science and society that emphasizes reciprocity and meeting public needs.
Meslin
Eric M
EM
Indiana University Center for Bioethics, IU School of Medicine, Indianapolis, Ind. 46202, USA. emeslin@iupui.edu
Cho
Mildred K
MK
D032984:Ethics, Research; D016045:Human Genome Project; D006801:Humans; D057285:Precision Medicine; D012952:Societies
Med J Aust. 2007 Mar 5;186(5):220-1
17391080
Public Health Genomics. 2010;13(4):207-14
20395689
Am J Public Health. 2009 Dec;99(12):2128-34
19833988
N Engl J Med. 2010 Jul 15;363(3):204-7
20538622
J Law Med Ethics. 2005 Spring;33(1):15-21
15934662
McGill Law J. 2000 May;45(2):437-60
12688281
Philos Public Aff. 1978 Spring;7(3):187-205
11662480
JAMA. 1998 Dec 9;280(22):1951-8
9851484
Genet Med. 2008 Oct;10(10):709-10
18813136
Am J Med Genet A. 2008 Feb 1;146A(3):305-11
18203186
Soc Sci Med. 2005 Jan;60(2):331-44
15522489
IRB. 2001 Jul-Aug;23(4):9-12
11831280
EMBO Rep. 2006 Jul;7(7):661-6
16819458
Science. 2009 Jul 3;325(5936):28-30
19574366
Nature. 1999 Dec 2;402(6761 Suppl):C81-4
10591229
J Clin Epidemiol. 2005 Nov;58(11):1081-8
16223649
Scand J Public Health. 2004;32(3):224-9
15204184
Genet Med. 2009 Aug;11(8):568-9
19606051
Clin Pharmacol Ther. 2008 Sep;84(3):362-9
18500243
Nature. 2010 Apr 1;464(7289):649-50
20360688
J Med Ethics. 2005 Jul;31(7):415-8
15994363
Med Soc (Berkeley). 1996;:1-466
11619509
Pathobiology. 2008;75(6):323-9
19096227