title: Isolation of putative biosynthetic intermediates of prenylated indole alkaloids from a thermophilic fungus Talaromyces thermophilus.
abstract: The putative key biosynthetic intermediates of prenylated indole alkaloids have long been proposed but never isolated. Two such alkaloids, named talathermophilins A and B (1 and 2), were isolated from a thermophilic fungus Talaromyces thermophilus strain YM1-3 and were identified by NMR and MS spectroscopic analyses. The ratio of 1 and 2 in the culture broths was unexpectedly rather constant (about 2:3), which even remained unchanged despite the addition of exogenous 1 or 2, suggesting that talathermophilins might be of special function for the extremophilic fungus.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, PR China.
authors.forename: Yan-Sheng
authors.initials: YS
authors.lastname: Chu
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Guo
authors.forename: Wen-Zheng
authors.initials: WZ
authors.lastname: Pan
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Huang
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D054876:Prenylation; D032901:Talaromyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D026121:Indole Alkaloids