title: Breath analysis of hydrogen peroxide as a diagnostic tool.
abstract: The potential diagnostic significance of exhaled hydrogen peroxide (H(2)O(2)) in pulmonary and systemic disorders has received considerable interest over the last few decades. Despite large physiologic variability and low specificity, airway H(2)O(2) generation has been found to be consistently increased by inflammatory conditions. Furthermore, the level of exhaled H(2)O(2) has been associated with efficacy of treatment in various pulmonary diseases. To evaluate this potential biomarker, detection methods including standardization protocols have been developed. Despite these advances, more comprehensive and controlled studies are required. In this manuscript we review progress to date in the analytical measurement of exhaled H(2)O(2) and speculate on its potential clinical significance as a diagnostic tool.
authors.affiliation: Department of Cardiovascular Physiology, Medical University of Lodz, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Stolarek
authors.forename: Piotr
authors.initials: P
authors.lastname: Bialasiewicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Krol
authors.forename: Dariusz
authors.initials: D
authors.lastname: Nowak
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D019963:Clinical Chemistry Tests; D003933:Diagnosis; D045853:Exhalation / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000737:chemistry
chemical_list: D015415:Biomarkers; D006861:Hydrogen Peroxide