Cocaine selectively increases proliferation in the adult murine hippocampus.
Cocaine abuse continues to be a significant problem in the USA and elsewhere. Cocaine is an indirect agonist for dopamine, norepinephrine and serotonin with numerous potential downstream effects, including processes and signals associated with adult neurogenesis. Since drug addiction is associated with brain plasticity, we hypothesized that cocaine exposure would alter cellular proliferation in two adult neurogenic regions (the subventricular and subgranular zones). We used bromodeoxyuridine (BrdU) to track newly generated cells in the brains of adult mice after chronic cocaine or saline exposures. No differences were found in the number or migration patterns of BrdU-labeled cells in the forebrain neurogenic areas. However, cocaine produced a significant increase in the number of hippocampal BrdU-labeled cells.
Lloyd
Steven A
SA
Department of Psychology, North Georgia College & State University, 82 College Circle, Dunlap Hall, Room 202B, Dahlonega, GA 30597, USA. salloyd@northgeorgia.edu
Balest
Zachary R
ZR
Corotto
Frank S
FS
Smeyne
Richard J
RJ
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000473:pathology*; D004195:Disease Models, Animal; D018765:Dopamine Uptake Inhibitors / Q000633:toxicity; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology
D018765:Dopamine Uptake Inhibitors; D003042:Cocaine
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