title: Hydroa vacciniforme with mucosal involvement and recalcitrant periodontitis and multiple virus re-activators after sun-exposure.
abstract: An 8-year-old boy presented with hydroa vacciniforme with recurrent oral mucosal ulcers and treatment-resistant gingivitis/periodontitis. Symptoms of oral mucosal involvement and gingivitis/periodontitis mirrored the severity of the skin lesions in sun-exposed areas. Although Epstein-Barr virus was negative in the skin lesions, Epstein-Barr virus DNA was detected in the gingival lesions when skin disease activity increased. Human herpes viruses-6 and -7 were also positive in the gingival lesions. Notably, human parvovirus B19 DNA was detected in both skin and gingival lesions. Impairment of systemic immunity was not detected. This report describes a rare case of hydroa vacciniforme with mucosal involvement and periodontal disease accompanied by multiple local virus re-activation.
authors.affiliation: Department of Dermatology, Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Nishizawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Satoh
authors.forename: Kaoru
authors.initials: K
authors.lastname: Takayama
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yokozeki
mesh_terms: D002648:Child; D004279:DNA, Viral / Q000302:isolation & purification; D005891:Gingivitis / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D006837:Hydroa Vacciniforme / Q000473:pathology / Q000821:virology*; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology / Q000821:virology*; D019226:Oral Ulcer / Q000473:pathology / Q000821:virology*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D010518:Periodontitis / Q000473:pathology / Q000821:virology*; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology / Q000821:virology; D013472:Sunlight / Q000009:adverse effects*; D014775:Virus Activation
chemical_list: D004279:DNA, Viral