title: Post-transplantation diabetes mellitus; frequency and related risk factors: a single center study.
abstract: Post-transplantation diabetes mellitus (PTDM) is a serious complication after organ transplantation, which could lead to cardiovascular morbidity and mortality. The rate of PTDM increased in recent years, probably due to new immunosuppressive drugs such as Tacrolimus. In this study, we retrospectively evaluated the frequency of PTDM and related risk factors in 644 non diabetic patients who underwent renal transplantation. Data was analyzed by chi-square and Fisher's exact test in SPSS software ver11.5. Among 644 patients PTDM developed in 10.2% similar to literature. PTDM was significantly correlated to age (P value = 0.000), positive familial history (P= 0.003) and HBV infection (P= 0.046). In conclusion, PTDM is not uncommon in Iranian patients and a positive family history of diabetes, HBV infection and older age increases the likelihood to develop PTDM.
authors.affiliation: Urmia University of Medical Sciences, Department of Internal Medicine, Imam Khomeini Training Hospital, Urmia, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ghafari
authors.forename: Reza
authors.initials: R
authors.lastname: PourAli
authors.forename: Nariman
authors.initials: N
authors.lastname: Sepehrvand
authors.forename: Sanaz
authors.initials: S
authors.lastname: Hatami
authors.forename: Vanooshe
authors.initials: V
authors.lastname: Modarres
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D002648:Child; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents