Cardiovascular risk factors in relatives of type 2 diabetics with normal glucose tolerance test and elevated one-hour plasma glucose.
BACKGROUND
To investigate the effect of elevated one hour post-load plasma glucose on cardiovascular risk factors, in normal glucose tolerance (NGT) people, who are first degree relatives of type 2 diabetics.


METHODS
A cross-sectional study on 1475 NGT subjects (Arian ethnicity), who had one hour post-load plasma glucose was carried out. We compared the mean of age, sex, body mass index, waist circumference, blood pressure, lipid profile, and area under the curve of glucose (AUC-G) of 1190 out of 1475 NGT subjects with one hour plasma glucose (1hpG) ≥155 mg/dL, and 285 NGT subjects with 1hpG < 155 mg/dL.


RESULTS
The mean age, body mass index, waist circumference, blood pressure, lipid profile (but not low HDL-cholesterol), and area under the curve of glucose (AUC-G) was significantly higher in NGT subjects with 1hpG ≥155 mg/dL (P < 0.05). Normal glucose tolerance people (first degree relatives of type 2 diabetic patients) with 1hpG ≥155 mg/dL were older and heavier than those with 1hpG < 155 mg/dL. Cardiovascular risk factors (but not low HDL and hypertension) were more prevalent in those with elevated one hour post-load group (P < 0.05).


CONCLUSIONS
NGT subjects with elevated one hour post-load plasma glucose (1hpG ≥155 mg/dL) had higher prevalence of most cardiovascular risk factors in comparison with those with 1hpG < 155 mg/dL.
Taheri
Nader
N
Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Iraj
Bijan
B
Amini
Massoud
M
Amini
Payvand
P
Aminorroaya
Ashraf
A
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D001786:Blood Glucose