Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs.
We report the parallel synthesis of two natural cyclopeptides, isolated from the seeds of Annona squamosa, cyclosquamosin D (A1), and Met-cherimolacyclopeptide B (B) and their analogs. All of the compounds were screened for anti-inflammatory activity by evaluating their inhibitory effects on the production of pro-inflammatory cytokines using the lipopolysaccharide stimulated macrophage J774A.1 cell line. Compounds having significant anti-inflammatory activity in suppressing the secretion of IL-6 and TNF-α have been identified, some of which exhibit activity superior to that observed with the natural products.
Dellai
Afef
A
Faculté de Pharmacie, Laboratoire de Pharmacologie Marine, 5000 Monastir, Tunisia.
Maricic
Igor
I
Kumar
Vipin
V
Arutyunyan
Sergey
S
Bouraoui
Abderrahman
A
Nefzi
Adel
A
D000818:Animals; D031041:Annona / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; C555988:Met-cherimolacyclopeptide B; D010456:Peptides, Cyclic; D014409:Tumor Necrosis Factor-alpha; C527767:cyclosquamosin D
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