The effect of safranal on histamine (H(1)) receptors of guinea pig tracheal chains.
The effect of three concentrations of safranal on histamine (H(1)) receptors was tested on two groups of tracheal chains incubated with: 1) indomethacin, and 2) indomethacin, propranolol and atropine (n = 6). The EC(50) (effective concentration of histamine causing 50% of maximum response) obtained in the presence of chlorpheniramine and all concentrations of safranal in both groups were significantly greater than those of saline (p < 0.05 to p < 0.001). The EC(50) obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 μg/mL) in group 2 were greater than in group 1 (p < 0.05 to p < 0.001).
Boskabady
Mohammad Hossein
MH
Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran. boskabadymh@mums.ac.ir
Rahbardar
Mahbobaeh Ghasemzadeh
MG
Jafari
Zahra
Z
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002744:Chlorpheniramine / Q000494:pharmacology; D027622:Crocus / Q000737:chemistry*; D053138:Cyclohexenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D035264:Flowers; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000378:metabolism; D013729:Terpenes / Q000494:pharmacology*; D014132:Trachea
D053138:Cyclohexenes; D006634:Histamine H1 Antagonists; D010936:Plant Extracts; D011943:Receptors, Adrenergic, beta; D011969:Receptors, Histamine H1; D011976:Receptors, Muscarinic; D013729:Terpenes; D002744:Chlorpheniramine; C087963:safranal; D001285:Atropine; D006632:Histamine; D011433:Propranolol; D007213:Indomethacin