[Computer simulation of thyroid regulatory mechanisms in health and malignancy].
The paper describes a computer model for regulation of the number of thyroid follicular cells in health and malignancy. The authors'computer program for mathematical simulation of the regulatory mechanisms of a thyroid follicular cellular community cannot be now referred to as good commercial products. For commercialization of this product, it is necessary to draw up a direct relation of the introduced corrected values from the actually existing normal values, such as the peripheral blood concentrations of thyroid hormones or the mean values of endocrine tissue mitotic activity. However, the described computer program has been also used in researches by our scientific group in the study of thyroid cancer. The available biological experimental data and theoretical provisions on thyroid structural and functional organization at the cellular level allow one to construct mathematical models for quantitative analysis of the regulation of the size of a cellular community of a thyroid follicle in health and abnormalities, by using the method for simulation of the regulatory mechanisms of living systems and the equations of cellular community regulatory communities.
Abduvaliev
A A
AA
Gil'dieva
M S
MS
Khidirov
B N
BN
Saĭdalieva
M
M
Saatov
T S
TS
D002452:Cell Count; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D012984:Software; D013961:Thyroid Gland / Q000166:cytology* / Q000502:physiology; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000503:physiopathology