Imidazole-catalyzed monoacylation of symmetrical diamines.
An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.
Verma
Sanjeev K
SK
Process Technology Development Division, Defence R & D Establishment, Jhansi Road, Gwalior-474002 (MP) India.
Acharya
B N
BN
Kaushik
M P
MP
D000215:Acylation; D000605:Amino Alcohols / Q000737:chemistry; D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000605:Amino Alcohols; D003959:Diamines; D007093:Imidazoles; C029899:imidazole