[Levetiracetam modifies the pattern of audiogenic locomotive response in Wistar and Krushinsky-Molodkina strain rats].
The novel antiepileptic drug levetiracetam (keppra, 80 mg/kg, i.p.) produces a pronounced anticonvulsant effect on all parameters of the audiogenic locomotion response in Wistar rats, leading to the prevention of acoustic seizures approximately in 50% animals. Keppra injection also led to a decrease in the intensity of single audiogenic convulsive episode, a twofold prolongation of the latency of motor reaction, and a change in the pattern of seizure reaction toward increasing number of rats with "one-wave" response. In contrast, a lack of sound resistant animals and the change from one- to two-wave audiogenic response were observed in Krushinsky-Molodkina strain rats.
Malikova
L A
LA
Fedotova
I B
IB
Surina
N M
NM
Poletaeva
I I
II
Raevskiĭ
K S
KS
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D000077287:Levetiracetam; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010889:Piracetam / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D013045:Species Specificity
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam