Fatty acids, membrane viscosity, serotonin and ischemic heart disease.
Novel markers for ischemic heart disease are under investigation by the scientific community at international level.This work focuses on a specific platelet membrane fatty acid condition of viscosity which is linked to molecular aspects such as serotonin and G proteins, factors involved in vascular biology.A suggestive hypothesis is considered about the possibility to use platelet membrane viscosity, in relation to serotonin or, indirectly, the fatty acid profile, as indicator of ischemic risk.
Cocchi
Massimo
M
Institute Paolo Sotgiu Quantitative and Evolutionary Psychiatry and Cardiology, L.U.de.S. University, Via dei Faggi 4-Quartiere La Sguancia-Lugano-Pazzallo 6900, Switzerland. massimo.cocchi@unibo.it
Tonello
Lucio
L
Lercker
Giovanni
G
D000465:Algorithms; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry*; D005227:Fatty Acids / Q000097:blood*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008560:Membrane Fluidity / Q000502:physiology*; D017202:Myocardial Ischemia / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D012701:Serotonin / Q000097:blood / Q000502:physiology*; D014783:Viscosity
D015415:Biomarkers; D005227:Fatty Acids; D012701:Serotonin; D019204:GTP-Binding Proteins
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