Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease.
OBJECTIVE
To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.


METHODS
CAC was measured by electron beam tomography at the baseline and at a follow-up 6.0±0.5 years later. The study population included 443 participants with type 1 diabetes and 526 control subjects who were free of diagnosed coronary artery disease at baseline. The presence of renal disease was defined by the presence of albuminuria and/or low glomerular filtration rate.


RESULTS
In subjects without renal disease, serum UA predicted CAC progression (odds ratio 1.30 [95% CI 1.07-1.58], P=0.007) independent of conventional cardiovascular risk factors including diabetes and the presence of metabolic syndrome.


CONCLUSIONS
Serum UA levels predict the progression of coronary atherosclerosis and may be useful in identifying who is at risk for vascular disease in the absence of significant chronic kidney disease.
Rodrigues
Ticiana C
TC
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA.
Maahs
David M
DM
Johnson
Richard J
RJ
Jalal
Diana I
DI
Kinney
Gregory L
GL
Rivard
Christopher
C
Rewers
Marian
M
Snell-Bergeon
Janet K
JK
D000328:Adult; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007674:Kidney Diseases; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid
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