[Effect of antioxidants lipin and quercetin on indices of lipid peroxidation and antioxidant system in recipients of renal allotransplants].
Activation of the free-radical oxidation processes (FROP) in the environment of activity inhibition of antioxidant defense system (ADS) plays an important role in pathogenesis of an ischemic-reperfusion damage (IRD) of renal allotransplant (RAT), causes its dysfunction and shortens long-term survival. Along with standard measures there was proposed intraoperative intravenous administration of antioxidant "cocktail", containing preparations lipin and quercetin, to recipient before switching on the kidney into the blood circulation and further during 3-5 days postoperatively. There were studied up the impact of lipin and quercetin on indices of peroxidal oxidation of lipids, and ADS activity of the RAT recipients in early postoperative period. There was established, that these preparations inhibit activity of the FROP, raise the ADS potential in the recipient organism, promoting IRD severity reduction of RAT and acceleration of its function restoration,
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D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D016030:Kidney Transplantation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009930:Organic Chemicals / Q000008:administration & dosage / Q000627:therapeutic use; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D014184:Transplantation, Homologous; D055815:Young Adult
D000975:Antioxidants; D009930:Organic Chemicals; C088310:lipine; D008315:Malondialdehyde; D011794:Quercetin; D002374:Catalase; D013482:Superoxide Dismutase