[Continuous versus intermittent azithromycin administration for treatment of Mycoplasma pneumonia-induced pneumonia: effects and drug resistance in rats].
OBJECTIVE
To evaluate the efficacy and drug resistance of azithromycin administered via continuous infusion versus intermittent administration in rats with Mycoplasma pneumonia-induced pneumonia.


METHODS
Pneumonia was induced in rats by intranasal administration of mycoplasma suspension. The rats with established pneumonia were randomly divided into continuous and intermittent infusion groups with intraperitoneal azithromycin injection on a daily basis for 6 consecutive days, or for 3 consecutive days followed by a 3-day rest (which was repeated twice), respectively. The bronchoalveolar lavage (BAL) and venous blood were collected before and at 3, 6, 9, and 12 days during or after the treatments for MIC test. The rats were killed for lung pathological examination, and the plasma samples were obtained for drug assays by HPLC.


RESULTS
Pathological examination of the lungs demonstrated better improvement in the intermittent group than in continuous group. At 12 days of the treatment, the MIC value was higher in the continuous group than in the intermittent group.


CONCLUSIONS
Intermittent azithromycin administration produces better therapeutic effect against Mycoplasma pneumonia than continuous drug delivery in rats with less likeliness of inducing drug resistance.
Wei
Wei
W
Department of Pharmacy, No.81 Hospital of PLA, Nanjing 210002, China. weiwei100513@163.com
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D017963:Azithromycin / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004334:Drug Administration Schedule; D024881:Drug Resistance, Bacterial; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy* / Q000382:microbiology*; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D017963:Azithromycin