title: [Congenital gastroschisis--prenatal diagnosis and perinatal management].
abstract: The birth prevalence of gastroschisis is increasing world-wide. This situation applies particularly to young, slim women who smoke. At a first glance this is a paradox in light of the ever-increasing age of pregnant women among whom there are fewer and fewer smokers. In numerous studies it has been clearly demonstrated that not only (nutritional) teratogenic substances and environmental factors but also epidemiological causes can be held responsible for this phenomenon. Nowadays gastroschisis is detected prenatally in up to 90% of all foetuses. Advantages of a prenatal diagnosis include the identification of associated disorders and the determination of a high-risk constellation (IUGR, intraabdominal bowel dilatation or vanishing gut). This is essential for an adequate interdisciplinary counseling for the afflicted parents together with obstetricians, paediatric surgeons and neonatalogists. The efficacy of serial amnioexchanges with regard to a better neonatal outcome has as yet not been unambiguously clarified. The possibilities for surgical procedures on the foetus are limited and can at present only be considered as experimental attempts in animal models. From an obstetrical perspective the in utero transport and elective Caesarean section before completion of the 36 (th) week of gestation in a tertiary centre with appropriate facilities (paediatric surgery, neonatalogy) seem to be the course recommended by most authors in spite of inconclusive data. The survival rates for babies with gastroschisis after operative treatment (primary defect closure, silotechnique) are considerably high (>90%).
authors.affiliation: Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Campus Lübeck. jan.weichert@uk-sh.de
authors.forename: J
authors.initials: J
authors.lastname: Weichert
authors.forename: F O
authors.initials: FO
authors.lastname: Kahl
authors.forename: A
authors.initials: A
authors.lastname: Schröer
authors.forename: M K
authors.initials: MK
authors.lastname: Bohlmann
authors.forename: K
authors.initials: K
authors.lastname: Diedrich
authors.forename: D R
authors.initials: DR
authors.lastname: Hartge
mesh_terms: D005260:Female; D020139:Gastroschisis / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D018743:Perinatal Care / Q000379:methods*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*