Copper-catalyzed regio- and enantioselective synthesis of chiral enol acetates and β-substituted aldehydes.
The in situ transformation of α,β-unsaturated aldehydes into α-chloroallylic acetates and subsequent copper-catalyzed regio- and enantioselective (up to 94% ee) allylic alkylation with Grignard reagents provides chiral enol acetates and chiral β-substituted aldehydes in a one-pot protocol.
Fañanás-Mastral
Martín
M
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Feringa
Ben L
BL