[Gastric neuroendocrine tumors in a woman with systemic lupus erythematosus].
METHODS
A 56-year-old woman presented with pronounced petechia. She complained about recurrent fever and night sweat for two weeks, having felt unwell during the past years.


METHODS
Laboratory examinations showed thrombocytopenia, leukopenia and considerably elevated liver enzymes. Antinuclear antibodies and antibodies against double-stranded DNA were positive. Sonography showed a slightly enlarged liver with multiple surrounding lymph nodes, splenomegaly and chronic-atrophic thyroiditis. Gastroscopy revealed several polypes which were immunohistochemically classified as neuroendocrine tumors (NET).


METHODS
Systemic lupus erythematosus (SLE) with involvement of several organs was diagnosed and high doses of steroids were given. The steroid was then gradually reduced and changed to azathioprine. The NET were removed endoscopically.


CONCLUSIONS
Neuroendocrine tumors are rare and localised to the stomach in only 2 - 4 %. Only three cases of gastric NET in the context of SLE with autoimmune gastritis have been reported so far in the literature.
Döcker
D
D
Medizinische Klinik I, Klinikum am Steinenberg, Kreiskliniken Reutlingen gGmbH, Reutlingen. braun_b@kreisklinikenreutlingen.de
Marx
U
U
Braun
B
B
D000974:Antibodies, Antinuclear / Q000032:analysis; D001379:Azathioprine / Q000627:therapeutic use; D004247:DNA / Q000276:immunology; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000601:surgery; D013256:Steroids / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000150:complications* / Q000601:surgery
D000974:Antibodies, Antinuclear; D007166:Immunosuppressive Agents; D013256:Steroids; D004247:DNA; D001379:Azathioprine