Clustered K+ channel complexes in axons.
Voltage-gated K+ (Kv) channels regulate diverse neuronal properties including action potential threshold, amplitude, and duration, frequency of firing, neurotransmitter release, and resting membrane potential. In axons, Kv channels are clustered at a variety of functionally important sites including axon initial segments, juxtaparanodes of myelinated axons, nodes of Ranvier, and cerebellar basket cell terminals. These channels are part of larger protein complexes that include cell adhesion molecules and scaffolding proteins. These interacting proteins play important roles in recruiting K+ channels to distinct axonal domains. Here, I review the composition, functions, and mechanism of localization of these K+ channel complexes in axons.
Rasband
Matthew N
MN
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States. Rasband@bcm.edu
D000818:Animals; D001369:Axons / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D046912:Multiprotein Complexes / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism*; D025941:Protein Interaction Mapping; D021381:Protein Transport
D046912:Multiprotein Complexes; D015221:Potassium Channels
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