title: Comparison of the surface wave method and the indentation method for measuring the elasticity of gelatin phantoms of different concentrations.
abstract: The speed of the surface Rayleigh wave, which is related to the viscoelastic properties of the medium, can be measured by noninvasive and noncontact methods. This technique has been applied in biomedical applications such as detecting skin diseases. Static spherical indentation, which quantifies material elasticity through the relationship between loading force and displacement, has been applied in various areas including a number of biomedical applications. This paper compares the results obtained from these two methods on five gelatin phantoms of different concentrations (5%, 7.5%, 10%, 12.5% and 15%). The concentrations are chosen because the elasticity of such gelatin phantoms is close to that of tissue types such as skin. The results show that both the surface wave method and the static spherical indentation method produce the same values for shear elasticity. For example, the shear elasticities measured by the surface wave method are 1.51, 2.75, 5.34, 6.90 and 8.40kPa on the five phantoms, respectively. In addition, by studying the dispersion curve of the surface wave speed, shear viscosity can be extracted. The measured shear viscosities are 0.00, 0.00, 0.13, 0.39 and 1.22Pa.s on the five phantoms, respectively. The results also show that the shear elasticity of the gelatin phantoms increases linearly with their prepared concentrations. The linear regressions between concentration and shear elasticity have R(2) values larger than 0.98 for both methods.
authors.affiliation: Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Qiang
authors.forename: James
authors.initials: J
authors.lastname: Greenleaf
mesh_terms: D000465:Algorithms; D000818:Animals; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D020342:Finite Element Analysis; D005780:Gelatin; D016014:Linear Models; D019047:Phantoms, Imaging; D013499:Surface Properties; D013552:Swine; D014783:Viscosity
chemical_list: D005780:Gelatin
references.citation: J Magn Reson Imaging. 2009 Nov;30(5):1145-50
references.pmid: 19856447
references.citation: Appl Opt. 1998 May 1;37(13):2788-97
references.pmid: 18273225
references.citation: Stud Health Technol Inform. 2003;94:137-43
references.pmid: 15455879
references.citation: Biophys J. 2002 May;82(5):2798-810
references.pmid: 11964265
references.citation: J Acoust Soc Am. 2007 Nov;122(5):2522-5
references.pmid: 18189542
references.citation: Nat Med. 1996 May;2(5):601-3
references.pmid: 8616724
references.citation: J Biomech. 1996 May;29(5):679-85
references.pmid: 8707798
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1979 Jul;47(1):175-81
references.pmid: 468657
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar;54(3):498-509
references.pmid: 17375819
references.citation: Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6603-8
references.pmid: 10359758
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Jun;57(6):1358-67
references.pmid: 20529711
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Jul;57(7):1696-700
references.pmid: 20639163
references.citation: Ultrasound Med Biol. 1981;7(4):385-7
references.pmid: 7027579
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan;56(1):55-62
references.pmid: 19213632
references.citation: Phys Med Biol. 2005 Dec 7;50(23):5597-618
references.pmid: 16306655
references.citation: J Biomech. 2010 Feb 10;43(3):442-8
references.pmid: 19889419
references.citation: Neuroimage. 2009 Jul 1;46(3):652-7
references.pmid: 19281851
references.citation: Acad Radiol. 2008 Dec;15(12):1526-33
references.pmid: 19000869
references.citation: J Acoust Soc Am. 2004 Dec;116(6):3734-41
references.pmid: 15658723
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Apr;51(4):396-409
references.pmid: 15139541
references.citation: Skin Res Technol. 2009 Feb;15(1):55-67
references.pmid: 19152580
references.citation: J Am Acad Dermatol. 1999 Mar;40(3):436-42
references.pmid: 10071315
references.citation: Annu Rev Biomed Eng. 2003;5:57-78
references.pmid: 12704084
references.citation: J Appl Physiol (1985). 1994 Feb;76(2):565-71
references.pmid: 8175564
references.citation: J Acoust Soc Am. 1999 May;105(5):2941-50
references.pmid: 10335643
references.citation: Med Eng Phys. 1997 Sep;19(6):512-7
references.pmid: 9394898
references.citation: J Neurotrauma. 2003 Nov;20(11):1163-77
references.pmid: 14651804
references.citation: Med Eng Phys. 2007 Apr;29(3):307-15
references.pmid: 16750415
references.citation: Ultrason Imaging. 2003 Jan;25(1):17-38
references.pmid: 12747425
references.citation: Ultrason Imaging. 1997 Apr;19(2):112-26
references.pmid: 9381628
references.citation: Ann Rheum Dis. 2001 Mar;60(3):262-8
references.pmid: 11171689
references.citation: Opt Express. 1998 Sep 14;3(6):199-211
references.pmid: 19384362
references.citation: J Rheumatol. 1998 Jan;25(1):84-8
references.pmid: 9458208
references.citation: Science. 1998 Apr 3;280(5360):82-5
references.pmid: 9525861
references.citation: Gastroenterol Clin Biol. 2008 Sep;32(6 Suppl 1):68-72
references.pmid: 18973848
references.citation: J Acoust Soc Am. 2006 Feb;119(2):1238-43
references.pmid: 16521784
references.citation: Opt Express. 2009 Nov 23;17(24):21762-72
references.pmid: 19997419
references.citation: J Acoust Soc Am. 1976 Dec;60(6):1409-11
references.pmid: 1010892
references.citation: J Biomech. 1972 Sep;5(5):541-51
references.pmid: 4667277
references.citation: Ultrasound Med Biol. 2003 Jul;29(7):1053-60
references.pmid: 12878252
references.citation: Ultrasound Med Biol. 2008 Sep;34(9):1373-86
references.pmid: 18395961
references.citation: J Acoust Soc Am. 2008 Dec;124(6):3377-80
references.pmid: 19206764