title: Pituitary carcinoma diagnosed on fine needle aspiration: Report of a case and review of pathogenesis.
abstract: Pituitary carcinoma (PC) is a very rare entity (0.2% of all pituitary tumors), with only about 140 cases reported in English literature. There are no reliable histological, immunohistochemical or ultrastructural features distinguishing pituitary adenoma (PA) from PC. By definition, a diagnosis of PC is made after a patient with PA develops non-contiguous central nervous system (CNS) or systemic metastases. To date, only three cases of PC have been reportedly diagnosed on fine needle aspiration (FNA). Two of the reported cases were diagnosed on FNA of the cervical lymph nodes and one on FNA of the vertebral bone lesion. Herein, we present a case of PC, diagnosed on FNA of the liver lesion. In this case, we describe cytologic features of PC and compare them to histologic features of the tumor in the pituitary. Clinical behavior of tumor, pathogenesis of metastasis and immunochemical and prognostic markers will also be described.
authors.affiliation: Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Yakoushina
authors.forename: Ehud
authors.initials: E
authors.lastname: Lavi
authors.forename: R S
authors.initials: RS
authors.lastname: Hoda
references.citation: Pituitary. 2011 Mar;14(1):92-7
references.pmid: 18949563
references.citation: J Neurooncol. 2009 Apr;92(2):219-22
references.pmid: 19034384
references.citation: BMC Cancer. 2001;1:12
references.pmid: 11570981
references.citation: J Child Neurol. 2008 Dec;23(12):1467-71
references.pmid: 19073854
references.citation: Acta Cytol. 2006 Mar-Apr;50(2):225-30
references.pmid: 16610696
references.citation: Am J Surg Pathol. 2003 Apr;27(4):477-86
references.pmid: 12657932
references.citation: J Neurooncol. 2001 Jun;53(2):107-14
references.pmid: 11716064
references.citation: Cytojournal. 2005 Sep 20;2:16
references.pmid: 16174291
references.citation: Eur J Endocrinol. 2006 Oct;155(4):523-34
references.pmid: 16990651
references.citation: Endocr Pathol. 2007 Winter;18(4):217-22
references.pmid: 18026859
references.citation: AJR Am J Roentgenol. 2006 Jun;186(6):1548-50
references.pmid: 16714642
references.citation: Neurosurgery. 1998 Jun;42(6):1378-82; discussion 1382-3
references.pmid: 9632200
references.citation: Neuroendocrinology. 2006;83(3-4):179-88
references.pmid: 17047381
references.citation: Neurosurg Focus. 2004 Apr 15;16(4):E7
references.pmid: 15191336
references.citation: Neurosurgery. 2006 Aug;59(2):341-53; discussion 341-53
references.pmid: 16883174
references.citation: Endocrine. 2005 Oct;28(1):27-35
references.pmid: 16311407
references.citation: J Clin Endocrinol Metab. 2004 Feb;89(2):574-80
references.pmid: 14764764
references.citation: J Clin Endocrinol Metab. 2005 May;90(5):3089-99
references.pmid: 15741248
references.citation: Ultrastruct Pathol. 2001 May-Jun;25(3):227-42
references.pmid: 11465479
references.citation: Diagn Cytopathol. 1994;11(1):68-73
references.pmid: 7956665
references.citation: Pituitary. 1999 May;1(3-4):147-51
references.pmid: 11081192