Clinicopathological evaluation of downer dairy cows with fatty liver.
This study evaluated the relationship between severity of fatty liver and macromineral status in downer dairy cows and determined the usefulness of selected biochemical analytes for assessing prognosis. Blood and liver biopsy specimens were obtained from 36 Holstein downer cows shortly after the cows became recumbent and before they were treated. Liver tissue was examined histologically and serum activity of liver-derived enzymes and concentration of total lipids, triglycerides, bile acids, glucose, beta-hydroxybutyrate, acetoacetic acid, total bilirubin, non-esterified fatty acids (NEFA), cholesterol and macrominerals (Ca, Mg, K, Na, P) were determined. Fatty liver infiltration was severe in 44% of the cows and moderate in 44%. Serum activities of ornithine carbamoyltransferase and glutamate dehydrogenase, and NEFA/cholesterol ratio were good indicators of fatty liver. Cows with severe fatty liver had the lowest mean K values. The prognosis is guarded for downer cows with moderate and severe fatty liver and when total bilirubin concentration is high.
Kalaitzakis
Emmanouil
E
Clinic of Farm Animals, Aristotle University of Thessaloniki, Greece.
Panousis
Nikolaos
N
Roubies
Nikolaos
N
Giadinis
Nektarios
N
Kaldrymidou
Eleni
E
Georgiadis
Marios
M
Karatzias
Harilaos
H
D020155:3-Hydroxybutyric Acid / Q000378:metabolism; D000090:Acetoacetates / Q000378:metabolism; D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D019878:Carboxyl and Carbamoyl Transferases / Q000378:metabolism; D002417:Cattle / Q000378:metabolism; D002418:Cattle Diseases / Q000378:metabolism / Q000473:pathology*; D002784:Cholesterol / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005234:Fatty Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D007774:Lactation / Q000502:physiology*; D008099:Liver / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009751:Nutritional Requirements; D009752:Nutritional Status; D011379:Prognosis; D011644:Puerperal Disorders / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D012720:Severity of Illness Index; D014280:Triglycerides / Q000378:metabolism
D000090:Acetoacetates; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; C016635:acetoacetic acid; D002784:Cholesterol; D005969:Glutamate Dehydrogenase; D019878:Carboxyl and Carbamoyl Transferases; D001663:Bilirubin; D020155:3-Hydroxybutyric Acid
J Dairy Res. 2005 May;72(2):129-37
15909677
J Vet Intern Med. 2007 Jul-Aug;21(4):835-45
17708407
J Vet Med A Physiol Pathol Clin Med. 2004 Aug;51(6):294-9
15485565
J Biol Chem. 1957 May;226(1):497-509
13428781
J Vet Intern Med. 1997 Jul-Aug;11(4):231-7
9298478
Dtsch Tierarztl Wochenschr. 1993 Jun;100(6):225-30
8339707
Res Vet Sci. 1988 Nov;45(3):389-93
3212288
Dtsch Med Wochenschr. 1974 Apr 12;99(15):765-6
4834840
J Vet Intern Med. 1994 Nov-Dec;8(6):432-8
7884730
Acta Vet Scand. 1989;30(4):441-5
2640781
Dtsch Tierarztl Wochenschr. 1988 Apr;95(4):140-6
3292195
Clin Chem. 1976 Dec;22(12):2051-5
11903
Dtsch Tierarztl Wochenschr. 1993 May;100(5):177-81
8319543
Acta Vet Scand. 1983;24(4):337-48
6687103
Z Klin Chem Klin Biochem. 1974 May;12(5):226
4440114
J Dairy Sci. 1994 Jun;77(6):1521-8
8083410
Nord Vet Med. 1979 Mar;31(3):97-105
432107
Theriogenology. 2000 Sep 15;54(5):771-86
11101037
Zentralbl Veterinarmed A. 1984 Sep;31(8):567-76
6150588
J Clin Pathol. 1960 Mar;13:156-9
13821779
Dtsch Tierarztl Wochenschr. 1999 Jan;106(1):26-9
10028757
Res Vet Sci. 1989 Mar;46(2):231-7
2704889
Analyst. 1972 Feb;97(151):142-5
5037807
Res Vet Sci. 1980 May;28(3):373-6
7414092
J Dairy Sci. 2004 Oct;87(10):3105-24
15377589
Eur J Clin Chem Clin Biochem. 1991 Jul;29(7):435-56
1932364
Dtsch Tierarztl Wochenschr. 1991 Mar;98(3):79-82
2044469
Vet Q. 1999 Jun;21(3):71-7
10427630
J Vet Med Sci. 1994 Feb;56(1):21-6
7911334
Mol Cell Biol. 1997 Jul;17(7):3915-23
9199326
Clin Chim Acta. 1971 Jan;31(1):87-96
5544065
Vet Rec. 1980 Sep 20;107(12):281-4
7210422