[Modulation of platelet tyrosine phosphatases by arachidonic acid metabolites in diabetes mellitus complicated with acute pyogenic inflammation].
To estimate the ability of intracellular tyrosine phosphatases modulation by arachidonic acid metabolites in patients with diabetes mellitus 2 type during foot wounds healing the inhibitory analysis of platelets aggregation induced by ATP plus inhibitors of tyrosine phosphatases, cyclooxygenases and 5-lipoxygenases was performed in 16 patients during hospitalization, at 3-5, 10-14 and 30 days of therapy. It was shown that foot wound healing in diabetic patients was associated with optimization of proteins tyrosine phosphorylation and cells arachidonic acid metabolism. It means the diagnostic significance of tyrosine phosphorylation and eicosanoids to interpret the result of wound healing at diabetes mellitus.
Barinova
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D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000201:enzymology / Q000601:surgery; D017719:Diabetic Foot / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology / Q000601:surgery; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D017027:Protein Tyrosine Phosphatases; D002118:Calcium