title: Small peptide recognition sequence for intracellular sorting.
abstract: Increasing evidence indicate that complex arrays of short signals and recognition peptide sequence ensure accurate trafficking and distribution of transmembrane receptors and/or proteins and their ligands into intracellular compartments. Internalization and subsequent trafficking of cell-surface receptors into the cell interior is mediated by specific short-sequence peptide signals within the cytoplasmic domains of these receptor proteins. The short signals usually consist of small linear amino acid sequences, which are recognized by adaptor coat proteins along the endocytic and sorting pathways. In recent years, much has been learned about the function and mechanisms of endocytic pathways responsible for the trafficking and molecular sorting of membrane receptors and their ligands into intracellular compartments, however, the significance and scope of the short-sequence motifs in these cellular events is not well understood. Here a particular emphasis has been given to the functions of short-sequence signal motifs responsible for the itinerary and destination of membrane receptors and proteins moving into subcellular compartments.
authors.affiliation: Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA. kpandey@tulane.edu
authors.forename: Kailash N
authors.initials: KN
authors.lastname: Pandey
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D021941:Caveolae / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000378:metabolism; D006801:Humans; D021382:Protein Sorting Signals / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*
chemical_list: D021382:Protein Sorting Signals
references.citation: Nat Rev Mol Cell Biol. 2004 Jan;5(1):23-32
references.pmid: 14708007
references.citation: Traffic. 2007 May;8(5):512-22
references.pmid: 17451554
references.citation: Neuron. 2006 Jul 6;51(1):71-84
references.pmid: 16815333
references.citation: Mol Cell Endocrinol. 2002 Apr 25;190(1-2):19-27
references.pmid: 11997175
references.citation: J Cell Sci. 1999 Dec;112 ( Pt 23):4257-69
references.pmid: 10564644
references.citation: Nat Rev Mol Cell Biol. 2007 Mar;8(3):185-94
references.pmid: 17318224
references.citation: J Biol Chem. 1990 Feb 25;265(6):3116-23
references.pmid: 1968060
references.citation: Nature. 2008 Dec 18;456(7224):976-979
references.pmid: 19140243
references.citation: J Cell Sci. 2006 Jun 1;119(Pt 11):2321-31
references.pmid: 16723738
references.citation: Mol Cell Neurosci. 2005 Apr;28(4):747-56
references.pmid: 15797721
references.citation: J Cell Biol. 1990 Oct;111(4):1393-407
references.pmid: 2120240
references.citation: J Cell Biol. 1992 Apr;117(2):311-25
references.pmid: 1560028
references.citation: EMBO J. 2002 Sep 16;21(18):4915-26
references.pmid: 12234931
references.citation: J Cell Sci. 2005 Jun 1;118(Pt 11):2495-505
references.pmid: 15923662
references.citation: Cell. 1992 Jun 26;69(7):1143-57
references.pmid: 1535555
references.citation: J Biol Chem. 2000 Jun 2;275(22):17187-94
references.pmid: 10747918
references.citation: Curr Opin Cell Biol. 2004 Aug;16(4):379-91
references.pmid: 15261670
references.citation: Mol Cell Biol. 2006 Apr;26(8):3231-42
references.pmid: 16581796
references.citation: J Cell Biol. 1998 Jul 13;142(1):59-67
references.pmid: 9660863
references.citation: Cell. 1991 Dec 20;67(6):1203-9
references.pmid: 1760845
references.citation: Mol Biol Cell. 2007 May;18(5):1887-96
references.pmid: 17360967
references.citation: J Biol Chem. 2001 Mar 9;276(10):7079-85
references.pmid: 11112783
references.citation: J Biol Chem. 1998 Aug 14;273(33):21316-23
references.pmid: 9694892
references.citation: Annu Rev Pharmacol Toxicol. 2004;44:559-609
references.pmid: 14744258
references.citation: Traffic. 2005 Feb;6(2):157-70
references.pmid: 15634215
references.citation: J Cell Biol. 2005 Jan 3;168(1):155-63
references.pmid: 15623579
references.citation: Am J Physiol Cell Physiol. 2003 Oct;285(4):C750-62
references.pmid: 12801889
references.citation: Nat Rev Mol Cell Biol. 2003 May;4(5):409-14
references.pmid: 12728274
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2760-5
references.pmid: 15701692
references.citation: Nat Rev Mol Cell Biol. 2002 Aug;3(8):600-14
references.pmid: 12154371
references.citation: J Biol Chem. 1996 May 24;271(21):12185-90
references.pmid: 8647812
references.citation: J Cell Biol. 2002 Sep 2;158(5):833-9
references.pmid: 12213832
references.citation: J Biol Chem. 2002 Mar 1;277(9):7356-62
references.pmid: 11729201
references.citation: J Biol Chem. 2006 Feb 17;281(7):4348-53
references.pmid: 16368683
references.citation: Mol Biol Cell. 2001 Oct;12(10):2907-20
references.pmid: 11598180
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8072-7
references.pmid: 12060753
references.citation: J Cell Sci. 2001 Apr;114(Pt 8):1455-71
references.pmid: 11282022
references.citation: Mol Biol Cell. 2003 Feb;14(2):516-28
references.pmid: 12589051
references.citation: J Cell Biol. 2003 Oct 27;163(2):203-8
references.pmid: 14581447
references.citation: Curr Opin Cell Biol. 1994 Oct;6(5):726-33
references.pmid: 7530464
references.citation: J Mol Biol. 2005 Jan 7;345(1):1-20
references.pmid: 15567406
references.citation: Clin Nucl Med. 2008 Jun;33(6):398-401
references.pmid: 18496445
references.citation: Mol Biol Cell. 2003 Mar;14(3):858-70
references.pmid: 12631709
references.citation: Annu Rev Cell Dev Biol. 1999;15:705-32
references.pmid: 10611976
references.citation: Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):679-93
references.pmid: 16710756
references.citation: Nature. 2005 Jul 7;436(7047):78-86
references.pmid: 15889048
references.citation: J Biol Chem. 2007 Oct 12;282(41):29855-65
references.pmid: 17715130
references.citation: Mol Biol Cell. 2002 Mar;13(3):1071-82
references.pmid: 11907283
references.citation: Mol Biol Cell. 2002 Nov;13(11):4001-12
references.pmid: 12429842
references.citation: Curr Opin Cell Biol. 2007 Aug;19(4):417-25
references.pmid: 17631994
references.citation: Cell Signal. 2006 Oct;18(10):1560-71
references.pmid: 16725309
references.citation: Biochem Biophys Res Commun. 2007 Dec 21;364(3):540-8
references.pmid: 17963729
references.citation: Cell. 1986 Apr 11;45(1):15-24
references.pmid: 3955657
references.citation: Nat Cell Biol. 2006 Apr;8(4):317-28
references.pmid: 16565709
references.citation: J Immunol. 2008 May 15;180(10):6713-24
references.pmid: 18453591
references.citation: Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1242-7
references.pmid: 17227843
references.citation: Annu Rev Biochem. 2002;71:405-34
references.pmid: 12045102
references.citation: Mol Cell Biochem. 2010 Jan;334(1-2):81-98
references.pmid: 19941037
references.citation: Biochem J. 2000 May 1;347 Pt 3:613-21
references.pmid: 10769163
references.citation: Annu Rev Biochem. 2003;72:395-447
references.pmid: 12651740
references.citation: Cancer Res. 2005 Sep 15;65(18):8233-41
references.pmid: 16166299
references.citation: J Virol. 2008 Apr;82(7):3181-91
references.pmid: 18216114
references.citation: J Neurosci Res. 2004 Mar 15;75(6):835-44
references.pmid: 14994344
references.citation: J Cell Sci. 2005 Sep 1;118(Pt 17):3959-71
references.pmid: 16105874
references.citation: EMBO J. 1991 Nov;10(11):3247-53
references.pmid: 1655415
references.citation: Curr Opin Cell Biol. 2005 Oct;17(5):509-16
references.pmid: 16099636
references.citation: J Biol Chem. 2002 Nov 15;277(46):44044-9
references.pmid: 12221107
references.citation: J Clin Monit Comput. 2005 Oct;19(4-5):319-28
references.pmid: 16328946
references.citation: Biochem J. 2005 May 15;388(Pt 1):103-13
references.pmid: 15574117
references.citation: Traffic. 2001 Feb;2(2):111-23
references.pmid: 11247302
references.citation: J Biol Chem. 2002 Feb 15;277(7):4618-27
references.pmid: 11704663
references.citation: J Biol Chem. 1996 Nov 15;271(46):29009-15
references.pmid: 8910552
references.citation: Trends Cardiovasc Med. 2000 Oct;10(7):317-20
references.pmid: 11343973
references.citation: J Biol Chem. 1992 Aug 25;267(24):17110-5
references.pmid: 1324923
references.citation: Traffic. 2008 Jan;9(1):1-9
references.pmid: 17908284
references.citation: Cell. 1990 Nov 30;63(5):1061-72
references.pmid: 2257624
references.citation: J Cell Biol. 1996 Feb;132(4):565-76
references.pmid: 8647888
references.citation: Peptides. 2005 Jun;26(6):901-32
references.pmid: 15911062
references.citation: Biosci Rep. 2009 Feb;29(1):1-11
references.pmid: 19143591
references.citation: Nat Struct Biol. 2002 Apr;9(4):241-4
references.pmid: 11914729
references.citation: Curr Opin Cell Biol. 2007 Aug;19(4):436-45
references.pmid: 17662591
references.citation: Nature. 2003 Mar 6;422(6927):37-44
references.pmid: 12621426
references.citation: Traffic. 2008 Jun;9(6):893-909
references.pmid: 18397183
references.citation: J Biol Chem. 1999 Dec 17;274(51):36153-8
references.pmid: 10593899
references.citation: J Cell Biol. 2003 Dec 22;163(6):1281-90
references.pmid: 14691137
references.citation: Cell Signal. 2006 Oct;18(10):1549-59
references.pmid: 16677801
references.citation: Mol Endocrinol. 2001 Sep;15(9):1624-35
references.pmid: 11518811
references.citation: Cell. 2002 May 17;109(4):523-35
references.pmid: 12086608
references.citation: J Neurosci. 1999 Sep 1;19(17):7507-15
references.pmid: 10460257
references.citation: J Biol Chem. 1999 Jul 2;274(27):18851-6
references.pmid: 10383380
references.citation: Mol Biol Cell. 2001 Nov;12(11):3573-88
references.pmid: 11694590
references.citation: J Biol Chem. 2006 Jun 2;281(22):15044-9
references.pmid: 16533808