title: Predictors of the progression of dementia severity in brazilian patients with Alzheimer's disease and vascular dementia.
abstract: Introduction. This study evaluates the progression of dementia and identifies prognostic risk factors for dementia. Methods. A group of 80 Brazilian community residents with dementia (34 with Alzheimer's disease and 46 with vascular dementia) was assessed over the course of 2 years. Data were analyzed with Cox regression survival analysis. Results. The data showed that education predicted cognitive decline (HR = 1.2; P < .05) when analyzed without controlling for vascular risk factors. After the inclusion of vascular risk factors, education (HR = 1.32; P < .05) and hypertension were predictive for cognitive decline (HR = 38; P < .05), and Alzheimer's disease diagnosis was borderline predictive (P = .055). Conclusion. Vascular risk factors interacted with the diagnosis of vascular dementia. Education was a strong predictor of decline.
authors.affiliation: Dementia Outpatient Clinic and Behavioral Sciences Program, Neurology Service and Medical Sciences Post-Graduation Course, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul School of Medicine, Porto Alegre 90035-903, Brazil.
authors.forename: Márcia L
authors.initials: ML
authors.lastname: Chaves
authors.forename: Ana L
authors.initials: AL
authors.lastname: Camozzato
authors.forename: Cristiano
authors.initials: C
authors.lastname: Köhler
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kaye
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