Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy.
Filamentous M13 phage can be engineered to display cancer cell-targeting or tumor-homing peptides through phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer drugs to deliver them to the cancer cells. We studied the evolution of structures of the complexes between anionic filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric photosensitizer zinc naphthalocyanine. At specific phage-liposome ratios, multiple phage nanofibers and liposomes are interwoven into a "nanoweb." The chemical and biological properties of the phage-liposome nanoweb were evaluated for possible application in drug delivery. This study highlights the ability of phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells.
Kalarical Janardhanan
Sreeram
S
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, USA.
Narayan
Shoba
S
Abbineni
Gopal
G
Hayhurst
Andrew
A
Mao
Chuanbin
C
D017104:Bacteriophage M13 / Q000737:chemistry* / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry; D019151:Peptide Library; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*
D008081:Liposomes; D019151:Peptide Library; D017319:Photosensitizing Agents
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