Peripartum serum leptin and soluble leptin receptor levels in women with gestational diabetes.
The purpose of the study was to clarify the alterations in serum leptin and soluble leptin receptor levels at term and early postpartum in gestational diabetes mellitus (GDM). Twenty women with normal pregnancy and 20 with GDM were recruited and blood samples were taken on the day of delivery and Days 1, 3 and 5 after delivery. Serum leptin levels were significantly higher in women with GDM than in the controls before delivery and decreased significantly after delivery (p < 0.001). After delivery there were no significant differences in serum leptin concentrations between women with GDM and the controls. Serum soluble leptin receptor concentrations did not differ neither between the two groups, nor before or after delivery. Leptin may play a role in GDM through a positive correlation with insulin resistance.
Chen
Danqing
D
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xia
Guiyu
G
Xu
Ping
P
Dong
Minyue
M
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D020738:Leptin / Q000097:blood*; D058725:Peripartum Period / Q000097:blood*; D011247:Pregnancy; D054411:Receptors, Leptin / Q000097:blood*; D012016:Reference Values; D012680:Sensitivity and Specificity; D012995:Solubility; D047929:Term Birth; D013997:Time Factors; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D020738:Leptin; D054411:Receptors, Leptin