Effects of supervised aerobic exercise training on serum adiponectin and parameters of lipid and glucose metabolism in subjects with moderate dyslipidemia.
OBJECTIVE
To examine the effects of supervised aerobic exercise training on serum adiponectin and lipids, including triglyceride (TG)-rich lipoproteins, in moderate dyslipidemic subjects.


METHODS
Twenty-five dyslipidemic patients [mean body mass index (BMI)=24.6 kg/m²; mean age= 39 years; mean total cholesterol=226 mg/dL; mean TG=149 mg/dL] without metabolic syndrome, diabetes, and hypertension underwent supervised aerobic exercise training (60 min/day, 2 to 3 times/week) at an intensity of 60-80% of age-predicted maximal heart rate for 16 weeks. Lipoprotein cholesterol levels were measured by our established anion-exchange HPLC method.


RESULTS
Aerobic exercise training significantly decreased BMI, cholesterol levels of LDL- and IDL-, and markedly reduced VLDL-cholesterol at week 8 (-45%) and week 16 (-50%), but changes in TG and HDL-cholesterol were not significant. Adiponectin significantly increased by 51% and HOMA-R was significantly decreased at week 16, although changes in these parameters were not significant at week 8. There was no significant relationship between changes in adiponectin and in VLDL- or IDL- cholesterol, but changes in adiponectin were inversely but insignificantly associated with changes in BMI (r=-0.343, p=0.095).


CONCLUSIONS
These results suggest that supervised aerobic exercise training two to three times/week in the presence of body weight loss increases serum adiponectin with an improved lipid profile and insulin sensitivity at week 16 in non-obese moderate dyslipidemic patients, and that VLDL-cholesterol is markedly decreased by supervised aerobic exercise training.
Yoshida
Hiroshi
H
Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan. hyoshida@jikei.ac.jp
Ishikawa
Toshitsugu
T
Suto
Michiko
M
Kurosawa
Hideo
H
Hirowatari
Yuji
Y
Ito
Kumie
K
Yanai
Hidekatsu
H
Tada
Norio
N
Suzuki
Masato
M
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D050171:Dyslipidemias / Q000378:metabolism* / Q000473:pathology; D015444:Exercise; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011379:Prognosis; D014280:Triglycerides / Q000097:blood*
D052242:Adiponectin; D001786:Blood Glucose; D008074:Lipoproteins; D014280:Triglycerides; C030087:lipoprotein triglyceride