title: Transcriptional regulation during CD8 T-cell immune responses.
abstract: Naïve CD8 T cells differentiate in response to antigen stimulation. They acquire the capacity to express multiple effector molecules and mediate effector functions that contribute to infection control. Once antigen loads are reduced they revert progressively to a less activated status and eventually reach a steady-state referred to as "memory" that is very different from that of naive cells. Indeed, these "memory" cells are "ready-to-go" populations that acquired the capacity to respond more efficiently to antigen stimulation. They modify their cell cycle machinery in order to divide faster; they likely improve DNA repair and other cell survival mechanisms in order to survive during division and thus to generate much larger clones of effector cells; finally, they also mediate effector functions much faster. These modifications are the consequence of changes in the expression of multiple genes, i.e., on the utilization of a new transcription program.
authors.affiliation: INSERM U591 Faculté de Médecine René Descartes Paris, France.
authors.forename: Ivana
authors.initials: I
authors.lastname: Munitic
authors.forename: César
authors.initials: C
authors.lastname: Evaristo
authors.forename: Hsueh Cheng
authors.initials: HC
authors.lastname: Sung
authors.forename: Benedita
authors.initials: B
authors.lastname: Rocha
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D050436:Regulatory Elements, Transcriptional; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors