[Cryosurgery combined with Iodine-125 seed implantation in the treatment of unresectable lung cancer.].
BACKGROUND
As many lung cancer patients lose surgical possibility, it is important to explore new treatments to improve prognosis. The study is to observe adverse reactions and therapeutic effects of cryosurgery combined iodine-125 seeds implantation in treating advanced lung cancer patients.


METHODS
One hundred forty unresectable pulmonary cancer patients received percutaneous cryosurgery and iodine-125 implantation under CT guidance. Patients were followed-up 1 year, with CT scan, therapeutic effect, complications and survival time monitoriy.


RESULTS
The one hundred forty patients successfully received cryosurgery combined with iodine-125 seed implantation and one-year follow-up. The patients with 6 m posttreatment had complete remission (CR) of 93.4%, partial remission (PR) of 70.1%, stable disease (SD) of 7.4%, and progressive disease (PD) of 5.7%. The half-year and one-year survival rates were 94.3% and 65.7% respectively. The average KPS was improved from 66.9 to 76.3.


CONCLUSIONS
Cryosurgery combined with iodine-125 seed implantation is effective in treating unresectable lung cancer, providing a promising treatment protocol for unresectable lung cancer patients.
Zhou
Hongtao
H
Department of Microsurgery, Guangzhou Fuda Cancer Hospital, Guangzhou 510300, China.
Niu
Lizhi
L
Zhou
Liang
L
Mu
Feng
F
Zhang
Changming
C
Liang
Bing
B
Yang
Daming
D
Xu
Kecheng
K