title: Catalytic asymmetric synthesis of quaternary α-hydroxy trifluoromethyl phosphonate via chiral aluminum(III) catalyzed hydrophosphonylation of trifluoromethyl ketones.
abstract: The chiral hydrogenated tridentate Schiff base-aluminum(III) complex has been first applied in the catalytic enantioselective hydrophosphonylation of trifluoromethyl ketones. The side reactions related to phospha-Brook rearrangement were completely avoided, and the corresponding quaternary α-hydroxy trifluoromethyl phosphonates have been first synthesized in good yields with high enantioselectivities (up to 90% ee).
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Hui
authors.forename: Weiliang
authors.initials: W
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D002384:Catalysis; D017611:Fluorine Compounds / Q000737:chemistry*; D006900:Hydroxylation; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D008745:Methylation; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D010766:Phosphorylation; D013237:Stereoisomerism
chemical_list: D017611:Fluorine Compounds; D007659:Ketones; D008024:Ligands; D009943:Organophosphorus Compounds; C554302:alpha-hydroxy trifluoromethyl phosphonate; D000535:Aluminum