Acanthosis nigricans in a patient with lung cancer: a case report.
Some skin lesions may accompany malignancies. Acanthosis nigricans, one such lesion, is a paraneoplastic dermatosis characterized by hyperpigmented and velvety verrucose plaques observed as symetric eruptions. With this report, we aim to present a rare case of concomitant lung cancer and acanthosis nigricans. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. A 65-year-old patient who had hyperpigmented, hypertrophic and symmetric verrucose lesions at the flexor surfaces of the lower and upper extremities, face, palms and the axillary region. Thoracic computed tomography demonstrated a hypodense mass lesion with a dimension of 5 x 5.5 cm at the center of basal segment bronchi of the left pulmonary lobe. Fiberoptic bronchoscopy showed that the access to the lower left lobe was almost completely obstructed by the endobronchial lesion. The result of the histopathologic examination of the endobronchial tissue biopsy was reported as non-small cell (adenocarcinoma) lung cancer. Result of the histopathologic analysis of the punch biopsy of the skin lesions was reported as acanthosis nigricans .There are no pathognomonic dermatological findings for lung cancer. In conclusion, there are skin lesions that accompany lung cancer and we believe that these should be considered for differential diagnosis.
Serap
Duru
D
Dişkapi Yildirim Bayazit Education and Reserch Hospital, Chest Diseases Clinic, 06200 Ankara, Turkey.
Ozlem
Sever
S
Melike
Yüceege
Y
Alper
Dilli
D
Aynur
Albayrak
A
Ata Türker
Arıkök
A
Ardıç
Sadik
S
Thorax. 1988 May;43(5):414-5
2848329
J Am Acad Dermatol. 2000 Feb;42(2 Pt 2):357-62
10640933
Ann Thorac Cardiovasc Surg. 2009 Dec;15(6):397-400
20081750
J Am Acad Dermatol. 1991 Aug;25(2 Pt 2):361-5
1894773
Gynecol Oncol. 2002 Feb;84(2):332-4
11812096
J Am Acad Dermatol. 2003 Sep;49(3):541-3
12963928
Diabetes Care. 2004 Jun;27(6):1412-6
15161797
Dermatologica. 1988;176(3):133-7
3378650
J Dermatol Surg Oncol. 1980 Nov;6(11):923-7
6257767
Int J Dermatol. 2005 Jan;44(1):45-7
15663660
J Am Acad Dermatol. 1994 Jul;31(1):1-19; quiz 20-2
8021347
Pol Arch Med Wewn. 2009 Mar;119(3):180-3
19514649
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Nov;30(11):1991-5
1484439
Dermatol Clin. 2002 Jul;20(3):523-32
12170885
Cancer. 1962 Mar-Apr;15:364-82
13882755
Diabetes Care. 2002 Jun;25(6):1009-14
12032107
Curr Opin Oncol. 1999 Mar;11(2):139-44
10188080