title: Assessing mobility at home in people with early Parkinson's disease using an instrumented Timed Up and Go test.
abstract: Gait and mobility problems are prominent features of Parkinson's Disease (PD), and are difficult to observe clinically in early stages of PD. We previously reported that gait changes were measurable in early to mid-stage PD subjects, when we used inertial sensors during an instrumented Timed Up and Go test (iTUG). With the advent of wearable inertial sensors, home assessment of mobility has become possible. We tested six people with early PD and eight control subjects using the iTUG in the home and laboratory. Our objectives were to 1) investigate the feasibility of testing subjects at home, and 2) compare performance at home versus laboratory. We found that home iTUG testing is feasible and the patients with PD were more affected than the healthy control subjects when tested at home.
authors.affiliation: Functional and Applied Biomechanics Laboratory, Rehabilitation Medicine Department, National Institutes of Health-Clinical Center, Bethesda, MD 20892, USA. zampierigallac@mail.nih.gov
authors.forename: Cris
authors.initials: C
authors.lastname: Zampieri
authors.forename: Arash
authors.initials: A
authors.lastname: Salarian
authors.forename: Patricia
authors.initials: P
authors.lastname: Carlson-Kuhta
authors.forename: John G
authors.initials: JG
authors.lastname: Nutt
authors.forename: Fay B
authors.initials: FB
authors.lastname: Horak
mesh_terms: D001696:Biomechanical Phenomena; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods*; D010300:Parkinson Disease / Q000150:complications*; D010865:Pilot Projects; D011187:Posture
references.citation: Mov Disord. 2008;23 Suppl 2:S426-30
references.pmid: 18668623
references.citation: Neurorehabil Neural Repair. 2007 Jul-Aug;21(4):327-40
references.pmid: 17369513
references.citation: J Geriatr Psychiatry Neurol. 2003 Mar;16(1):53-8
references.pmid: 12641374
references.citation: IEEE Trans Biomed Eng. 2007 Dec;54(12):2296-9
references.pmid: 18075046
references.citation: IEEE Trans Neural Syst Rehabil Eng. 2010 Jun;18(3):303-10
references.pmid: 20388604
references.citation: Disabil Rehabil. 2008;30(16):1205-12
references.pmid: 18608387
references.citation: J Biomech. 2002 May;35(5):689-99
references.pmid: 11955509
references.citation: Mov Disord. 2006 Jan;21(1):34-44
references.pmid: 16127718
references.citation: Arch Neurol. 2002 Nov;59(11):1724-8
references.pmid: 12433259
references.citation: Trends Neurosci. 2002 Jun;25(6):302-6
references.pmid: 12086748
references.citation: J Neurol Neurosurg Psychiatry. 2010 Feb;81(2):171-6
references.pmid: 19726406