Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice.
Nesfatin-1 was recently identified as a peptide with anorexigenic effects that is localized in the hypothalamus and adipocytes. Not much is known about the effect of nesfatin-1 on gut motility. Food intake was measured after intracerebroventricular administration of nesfatin-1 in food-deprived mice. Antral and duodenal motility was assessed by using a manometric method in conscious fed mice. We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour.
Atsuchi
Kaori
K
Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Asakawa
Akihiro
A
Ushikai
Miharu
M
Ataka
Koji
K
Tsai
Minglun
M
Koyama
Kenichiro
K
Sato
Yuki
Y
Kato
Ikuo
I
Fujimiya
Mineko
M
Inui
Akio
A
D000818:Animals; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007276:Injections, Intraventricular; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000008:administration & dosage* / Q000378:metabolism; D000080866:Nucleobindins
D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C000630651:Nucb1 protein, mouse; D000080866:Nucleobindins