The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma.
BACKGROUND
The purpose of the present study was to detect the presence of BASC-like stem cell-related indicators, such as clara cell secretory protein (CCSP), Octamer-4 (OCT4) and Bmi-1, and evaluate their implications in the prognosis of patients with lung adenocarcinoma.


METHODS
Specimens of 134 cases of lung adenocarcinoma were collected after radical surgery from January 1999 to June 2004.


RESULTS
One hundred and twenty-six cases showed cells that were positive for CCSP, 99 cases positive for OCT4, 91 cases simultaneous expression of CCSP and OCT4 and 74 cases positive for Bmi-1. Bmi-1 was significantly higher in patients at stage III compared to patients at stages I and II. The pattern of survival curves showed that Bmi-1 was a significant prognostic factor of poor overall survival in lung adenocarcinoma patients (P = 0.0000), and the patients with OCT4(+) expression showed a greater increase in mortality than OCT4(-) patients (P = 0.0103). The results of univariate and multivariate Cox analysis revealed that the pathological stages of tumor node metastases (P = 0.037), OCT4 (P = 0.046) and Bmi-1 expression (P = 0.001) were independent prognostic factors.


CONCLUSIONS
OCT4 and Bmi-1 may be good biomarkers to predict the prognosis of patients with completely resected lung adenocarcinoma.
Zhang
Xue-Yan
XY
Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
Dong
Qiang-Gang
QG
Huang
Jin-Su
JS
Huang
Ai-Mi
AM
Shi
Chun-Lei
CL
Jin
Bo
B
Sha
Hui-Fang
HF
Feng
Jiu-Xian
JX
Geng
Qin
Q
Zhou
Jin
J
Xu
Hui-Li
HL
Han
Bao-hui
BH
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate; D014598:Uteroglobin / Q000378:metabolism*; D055815:Young Adult
C069077:BMI1 protein, human; D009687:Nuclear Proteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin; D063150:Polycomb Repressive Complex 1