title: Multimedia modeling of human exposure to chemical substances: the roles of food web biomagnification and biotransformation.
abstract: The Risk Assessment IDentification And Ranking (RAIDAR) model is refined to calculate relative human exposures as expressed by total intake, intake fraction (iF), and total body burden (TBB) metrics. The RAIDAR model is applied to three persistent organic pollutants (POPs) and six petrochemicals using four mode-of-entry emission scenarios to evaluate the effect of metabolic biotransformation estimates on human exposure calculations. When biotransformation rates are assumed to be negligible, daily intake and iFs for the nine substances ranged over six orders of magnitude and TBBs ranged over 10 orders of magnitude. Including biotransformation estimates for fish, birds, and mammals reduced substance-specific daily intake and iF by up to 4.5 orders of magnitude and TBB by more than eight orders of magnitude. The RAIDAR iF calculations are compared to the European Union System for the Evaluation of Substances (EUSES) model iF calculations and differences are discussed, especially the treatment of food web bioaccumulation. Model selection and application assumptions result in different rankings of human exposure potential. These results suggest a need to critically consider model selection and to include reliable biotransformation rate estimates when assessing relative human exposure and ranking substances for priority setting. Recommendations for further model evaluations and revisions are discussed.
authors.affiliation: Centre for Environmental Modelling and Chemistry, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J7B8, Canada. jonarnot@trentu.ca
authors.forename: Jon A
authors.initials: JA
authors.lastname: Arnot
authors.forename: Don
authors.initials: D
authors.lastname: Mackay
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Parkerton
authors.forename: Rosemary T
authors.initials: RT
authors.lastname: Zaleski
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Warren
mesh_terms: D001711:Biotransformation; D001822:Body Burden; D004781:Environmental Exposure; D020387:Food Chain; D006536:Heptanes / Q000633:toxicity; D001556:Hexachlorocyclohexane / Q000633:toxicity; D006801:Humans; D008954:Models, Biological; D019212:Multimedia; D018570:Risk Assessment
chemical_list: D006536:Heptanes; D001556:Hexachlorocyclohexane; C469781:2,2,4,6,6-pentamethylheptane