title: Restoration of nasal cytology after endoscopic turbinoplasty versus laser-assisted turbinoplasty.
abstract: BACKGROUND
  Insult from surgical trauma leads to a degeneration of the nasal epithelium, resulting in morphological-volumetric changes involving the entire cell or a specific cell component. Alterations in normal nasal mucosa were assessed by nasal cytology and other functional tests after either endoscopic turbinoplasty or laser-assisted turbinoplasty for reducing inferior turbinate enlargement.
  
  
  METHODS
  A total of 150 patients with chronic nasal obstruction due to inferior turbinate hypertrophy were randomly assigned to undergo laser-assisted turbinoplasty or endoscopic turbinoplasty. Preoperative and postoperative assessment at 1 and 3 months follow-up included active anterior rhinomanometry, measurement of mucociliary transport time (MCTt), and nasal cytology to determine whether improved nasal breathing was accompanied by a restoration of preoperative nasal cytology and MCTt. One year after the operation, nasal cytology was repeated to definitively evaluate the presence of surgery-related cytological damage.
  
  
  RESULTS
  At both postoperative visits, nasal resistance had decreased similarly in both treatment groups; mean MCTt was significantly shorter in the endoscopic turbinoplasty-treated group (p < 0.05); at both visits, the number of altered ciliated cells had increased in the laser-assisted turbinoplasty-treated group but decreased in the endoscopic turbinoplasty-treated group, which, unlike the laser-assisted turbinoplasty-treated group, was also noted to have progressed toward a significant improvement in the goblet-to-ciliated cell ratio (p < 0.01).
  
  
  CONCLUSIONS
  When compared with laser-assisted turbinoplasty, endoscopic turbinoplasty is a conservative technique for inferior turbinate reduction that allows better restoration of preoperative nasal cytology and shorter MCTt.
authors.affiliation: Department of Otorhinolaryngology, University of Foggia, Foggia, Italy. m.cassano@unifg.it
authors.forename: Michele
authors.initials: M
authors.lastname: Cassano
authors.forename: Carla
authors.initials: C
authors.lastname: Granieri
authors.forename: Alessandro Maselli
authors.initials: AM
authors.lastname: Del Giudice
authors.forename: Francesco
authors.initials: F
authors.lastname: Mora
authors.forename: Emily
authors.initials: E
authors.lastname: Fiocca-Matthews
authors.forename: Pasquale
authors.initials: P
authors.lastname: Cassano
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D016923:Cell Death; D004724:Endoscopy / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D053685:Laser Therapy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D009297:Nasal Mucosa / Q000293:injuries / Q000473:pathology* / Q000601:surgery; D025363:Rhinomanometry; D013529:Surgical Wound Dehiscence / Q000209:etiology* / Q000517:prevention & control; D014420:Turbinates / Q000473:pathology / Q000601:surgery*