title: SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos.
abstract: Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.
authors.affiliation: Graduate Institute of Basic Medical Sciences, Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan.
authors.forename: Ying-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Chuan-Kai
authors.initials: CK
authors.lastname: Chou
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Hung
authors.forename: I-Shing
authors.initials: IS
authors.lastname: Yu
authors.forename: Hsien-An
authors.initials: HA
authors.lastname: Pan
authors.forename: Shu-Wha
authors.initials: SW
authors.lastname: Lin
authors.forename: Pao-Lin
authors.initials: PL
authors.lastname: Kuo
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000473:pathology / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009028:Morula / Q000473:pathology; D011247:Pregnancy; D058112:Septins / Q000172:deficiency / Q000235:genetics*; D013077:Sperm Head / Q000473:pathology* / Q000502:physiology; D020554:Sperm Injections, Intracytoplasmic
chemical_list: C555146:SEPT12 protein, mouse; D058112:Septins