Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys.
Vaccines based on adenovirus (Ad) vectors are currently in development against several pathogens. However, neutralizing antibodies (NAb) to human adenovirus type 5 (AdHu5), the best-studied vector, are highly prevalent in humans worldwide. Less-prevalent adenoviruses, including human and simian serotypes, provide alternative vaccine platforms. In this study, sera from 200 Brazilian human subjects and New-World monkeys were tested for NAb titers to human serotypes AdHu5 and AdHu26 and chimpanzee-origin Ad viruses of serotype 6 (AdC6) and serotype 68 (AdC68). Seroprevalence rates of NAb in humans were 69.5% for AdHu5, 44% for AdHu26, 21% for AdC6 and 23.5% for AdC68. In addition, NAb titers to human Ad were consistently higher than those found to simian serotypes. Surprisingly, sera from some New-World monkey species were able to neutralize AdC6 and/or AdC68. A possible explanation for these findings and the implications for the development of Ad-vector vaccines are discussed in detail.
Ersching
Jonatan
J
Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil.
Hernandez
Malva I M
MI
Cezarotto
Fabrizzio S
FS
Ferreira
Jovino D S
JD
Martins
Amely B
AB
Switzer
William M
WM
Xiang
Zhiquan
Z
Ertl
Hildegund C J
HC
Zanetti
Carlos R
CR
Pinto
Aguinaldo R
AR
D000257:Adenoviridae Infections / Q000276:immunology* / Q000662:veterinary*; D000260:Adenoviruses, Human / Q000276:immunology*; D000261:Adenoviruses, Simian / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D001938:Brazil; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051078:Platyrrhini; D018419:Primate Diseases / Q000276:immunology* / Q000821:virology; D016036:Seroepidemiologic Studies; D055815:Young Adult
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral