Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion.
Simple oil-in-water emulsion led to structural complexity at both the surface and interior of the PLGA microsphere. A golf ball-like dimpled surface comes from the heteroaggregation of volatile nonsolvent colloid originating from the inside of the organic droplet as supported by in situ optical microscopy. The internal porous structure and encapsulation of hydrophobic agent inside the microparticle implies its potential application as a drug carrier.
Kim
Mi Ri
MR
Division of Advanced Materials Engineering and Institute for Rare Metals, Kongju National University, Cheonan, Chungnam, 331-717, Korea.
Lee
Seungwoo
S
Park
Jung-Ki
JK
Cho
Kuk Young
KY
D004655:Emulsions; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
D004655:Emulsions; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid