title: The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients.
abstract: Cytochrome P450 (CYP) 1A2 gene polymorphisms are thought to be involved in the metabolism of theophylline (TP). We aimed to investigate the effect of CYP1A2*1C, CYP1A2*1D, CYP1A2*1E, and CYP1A2*1F polymorphisms of the CYP1A2 on TP metabolism by PCR-RFLP in 100 Turkish patients with chronic obstructive pulmonary disease (COPD) receiving TP. One hundred and one healthy volunteers were included as control group. The genotype frequencies of the CYP1A2*1D and CYP1A2*1F were found to be significantly different in the patients compared to the controls. The "T" allele at -2467 delT and the "C" allele at -163 C > A in the CYP1A2 displayed association with a significantly increased risk for COPD. "T" allele at - 2467 delT was also associated with a high risk of disease severity in COPD. In conclusion, our data suggest that genetic alterations in CYP1A2 may play a role both in the pharmacogenetics of TP and in the development of COPD.
authors.affiliation: Department of Chest Diseases, Medical Park Hospital, Antalya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uslu
authors.forename: Candan
authors.initials: C
authors.lastname: Ogus
authors.forename: Tulay
authors.initials: T
authors.lastname: Ozdemir
authors.forename: Turker
authors.initials: T
authors.lastname: Bilgen
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tosun
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Keser
mesh_terms: D000368:Aged; D000483:Alleles; D001993:Bronchodilator Agents / Q000097:blood* / Q000627:therapeutic use; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D013806:Theophylline / Q000097:blood* / Q000627:therapeutic use; D014421:Turkey; D044465:White People / Q000235:genetics*
chemical_list: D001993:Bronchodilator Agents; D013806:Theophylline; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2