Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood.
Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T cells using chimeric antigen receptors, and generating cord blood-derived natural killer cells and regulatory T cells.
Hanley
Patrick J
PJ
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.
Cruz
Conrad Russell
CR
Shpall
Elizabeth J
EJ
Bollard
Catherine M
CM
D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects; D005312:Fetal Blood / Q000166:cytology; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D019172:Transplantation Conditioning / Q000009:adverse effects; D014777:Virus Diseases / Q000209:etiology / Q000276:immunology / Q000628:therapy*
D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins
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