The antifungal activity of human parotid secretion is species-specific.
Candida albicans is the major fungal colonizer of the oral cavity and causes oral candidiasis in immunocompromised patient populations. While antifungal proteins in saliva have been identified and the virulence factors of C. albicans have been well studied, little is known about the role saliva plays in the preferential colonization of the oral cavity by C. albicans. We report that the fungistatic activity of human parotid secretion toward six C. albicans strains is considerably lower than towards nine non-C. albicans fungal species (average IC₅₀ values >1000 mg/l and <70 mg/l, respectively). The species-specific activity of parotid secretion suggests that saliva may play a determining role in oral fungal colonization patterns.
Hanasab
Homan
H
Department of Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA.
Jammal
Daniel
D
Oppenheim
Frank G
FG
Helmerhorst
Eva J
EJ
D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000276:immunology*; D015169:Colony Count, Microbial; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D010306:Parotid Gland / Q000502:physiology*; D012463:Saliva / Q000737:chemistry / Q000276:immunology*
D000935:Antifungal Agents
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