title: Obstetrical and neonatal outcomes of pregnancies following gastric bypass surgery: a retrospective cohort study in a French referral centre.
abstract: BACKGROUND
  The objective of this study was to analyze obstetrical and neonatal outcomes following Roux en Y Gastric Bypass procedures (RYGBP).
  
  
  METHODS
  A retrospective cohort study was conducted in a single French tertiary perinatal care and bariatric center. The study involved 24 pregnancies, following RYGBP (exposed group) and two different control groups (non-exposed groups). A body mass index (BMI)-matched control group included 120 pregnancies matched for age, parity, and pregnancy BMI. A normal BMI control group included 120 pregnancies with normal BMI (18.5-24.9 kg/m(2)), matched for age and parity. Hospital data were reviewed from all groups in the same 6-year period. Obstetrical and neonatal outcomes after RYGB were compared, separately, to the two different-matched control groups.
  
  
  RESULTS
  The median interval from RYGBP to conception was 26.6 (range: 3-74) months. Rates of perinatal complications did not differ significantly between the RYGBP group and normal BMI and BMI-matched controls groups. The rate of Cesarean section before labor was higher in the RYGBP patients than in the normal BMI control group (25% vs. 9.3% respectively, p = 0.04). Weight gain was lower in the RYGBP patients than normal BMI control group (5.8 kg vs. 13.2 kg respectively, p < 0.0001). Birthweight was also lower in the RYGBP group than those in normal BMI and BMI-matched controls groups (2,948.2 g vs. 3,368.2 g and 3,441.8 g, respectively, p < 0.0001).
  
  
  CONCLUSIONS
  RYGBP surgery was associated with reduced birthweight, suggesting a possible role of nutritional growth restriction in pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, Assistance Publique-Hôpitaux de Paris, Louis Mourier Hospital, 178 rue des Renouillers, 92700, Colombes, France.
authors.forename: Pietro
authors.initials: P
authors.lastname: Santulli
authors.forename: Laurent
authors.initials: L
authors.lastname: Mandelbrot
authors.forename: Enrico
authors.initials: E
authors.lastname: Facchiano
authors.forename: Chloé
authors.initials: C
authors.lastname: Dussaux
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Ceccaldi
authors.forename: Séverine
authors.initials: S
authors.lastname: Ledoux
authors.forename: Simon
authors.initials: S
authors.lastname: Msika
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D015390:Gastric Bypass / Q000009:adverse effects*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009765:Obesity / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
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