Extrinsic regulation of satellite cell specification.
Cellular commitment during vertebrate embryogenesis is controlled by an interplay of intrinsic regulators and morphogenetic signals. These mechanisms recruit a subset of cells in the developing organism to become the ancestors of skeletal muscle. Signals that control progression through the myogenic lineage converge on a battery of hierarchically organized transcription factors which modulate the cells to either remain in a primitive state or allow their commitment and differentiation into skeletal muscle fibers. A small population of cells will retain a largely unspecified state throughout development. Such stem cells, in conjunction with more committed myogenic progenitors, form a heterogeneous population that colonizes adult skeletal muscle as satellite cells. The satellite cell pool is responsible for the remarkable regenerative capacity of skeletal muscle. Similar to their counterparts during embryonic development, satellite cells are capable of self-renewal and can give rise to myogenic progeny. Impaired satellite cell homeostasis has been associated with numerous muscular disorders. Due to intense research efforts in the past two decades, the complex biology of muscle stem cells has now revealed some of its secrets and new avenues for the development of therapeutic molecules have emerged. In the present review we focus on the extrinsic mechanisms that control self-renewal, specification and differentiation of satellite cells and their significance for the development of biologic drugs.
Bentzinger
C Florian
CF
The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario K1 H 8L6, Canada. fbentzinger@ohri.ca
von Maltzahn
Julia
J
Rudnicki
Michael A
MA
D002454:Cell Differentiation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D024510:Muscle Development / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology / Q000196:embryology*; D012038:Regeneration / Q000502:physiology; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction; D055153:Stem Cell Niche
D036341:Intercellular Signaling Peptides and Proteins
Am J Pathol. 2004 Mar;164(3):1007-19
14982854
Exp Cell Res. 2010 Nov 1;316(18):3050-8
20570674
Aging (Albany NY). 2009 May 13;1(5):451-7
20157530
Nature. 2005 Feb 17;433(7027):760-4
15716955
Biochem Biophys Res Commun. 2000 May 27;272(1):138-43
10872817
Exp Cell Res. 1979 Sep;122(2):317-26
510407
Nature. 1997 May 1;387(6628):83-90
9139826
Exp Cell Res. 1984 May;152(1):154-60
6714317
Dev Biol. 1987 Jul;122(1):11-20
3297850
J Physiol. 1999 Apr 15;516 ( Pt 2):583-92
10087355
FEBS Lett. 2002 Jul 3;522(1-3):156-60
12095637
Eur Cytokine Netw. 1990 Oct-Nov;1(4):215-9
1966552
Cell Stem Cell. 2008 Jan 10;2(1):22-31
18371418
Anim Sci J. 2010 Feb;81(1):11-20
20163667
Am J Physiol Cell Physiol. 2000 Jan;278(1):C174-81
10644525
J Biol Chem. 2008 Jul 11;283(28):19371-8
18453534
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7479-84
19383783
Lancet. 2002 Feb 23;359(9307):687-95
11879882
J Cell Physiol. 1989 Feb;138(2):311-5
2918032
Cell. 2003 Jun 27;113(7):841-52
12837243
Drugs Today (Barc). 2007 Mar;43(3):149-55
17380212
Neurosci Lett. 1995 Dec 29;202(1-2):121-4
8787846
Development. 2005 Feb;132(4):689-701
15659485
Curr Top Dev Biol. 1998;38:225-87
9399080
Am J Physiol Cell Physiol. 2006 Jun;290(6):C1487-94
16684931
Growth Horm IGF Res. 2010 Aug;20(4):275-81
20494600
Nat Biotechnol. 2008 Jul;26(7):743-51
18612293
FEBS Lett. 2007 Jun 12;581(14):2727-32
17531227
Genes Dev. 2005 Jun 15;19(12):1426-31
15964993
Annu Rev Cell Dev Biol. 2004;20:61-86
15473835
J Biophys Biochem Cytol. 1961 Feb;9:493-5
13768451
J Gerontol A Biol Sci Med Sci. 2003 Oct;58(10):M911-6
14570858
FASEB J. 2005 Jun;19(8):934-42
15923403
Dev Biol. 2010 Aug 1;344(1):259-71
20478295
Nature. 2002 Nov 28;420(6914):418-21
12459784
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):945-50
16418263
Aging Cell. 2009 Dec;8(6):676-89
19732043
Dev Biol. 1996 Apr 10;175(1):84-94
8608871
Nature. 2006 Jun 29;441(7097):1075-9
16810242
Eur J Cancer. 2010 May;46(7):1232-40
20307969
Pediatr Res. 2004 Dec;56(6):831-41
15531741
Nature. 2005 Jun 16;435(7044):954-8
15843802
Trends Mol Med. 2008 Feb;14(2):82-91
18218339
J Appl Physiol (1985). 2006 Jun;100(6):1778-84
16439513
Curr Opin Investig Drugs. 2006 Apr;7(4):371-80
16625824
Dev Biol. 2001 Nov 1;239(1):79-94
11784020
Science. 2007 Aug 10;317(5839):807-10
17690295
Endocrinology. 2002 Feb;143(2):511-6
11796505
Dev Biol. 2007 Apr 1;304(1):246-59
17239845
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4318-22
18334646
Nature. 2005 Jun 16;435(7044):948-53
15843801
Cell Stem Cell. 2009 Jun 5;4(6):535-47
19497282
J Cell Physiol. 2009 Dec;221(3):526-34
19688776
Biol Res. 2004;37(4):635-9
15712402
Physiol Rev. 2004 Jan;84(1):209-38
14715915
Curr Opin Genet Dev. 2005 Aug;15(4):371-80
15950454
J Neuroimmunol. 1995 Mar;57(1-2):85-91
7706442
J Cell Sci. 2006 Sep 15;119(Pt 18):3822-32
16926191
J Lab Clin Med. 1997 Nov;130(5):476-86
9390635
Mol Ther. 2002 May;5(5 Pt 1):517-27
11991742
Genome Res. 1997 Sep;7(9):910-6
9314496
Cell Stem Cell. 2008 Jan 10;2(1):50-9
18371421
J Biol Chem. 1986 Mar 25;261(9):4337-45
3456347
Cold Spring Harb Symp Quant Biol. 2008;73:323-31
19329572
Dev Biol. 2006 Jun 1;294(1):50-66
16554047
Am J Physiol. 1989 Jun;256(6 Pt 1):C1262-6
2735398
Genes Dev. 1997 Aug 15;11(16):2040-51
9284044
Nat Med. 2007 Feb;13(2):204-10
17237794
Mol Cell Biol. 2003 Sep;23(17):6037-48
12917328
J Intern Med. 2009 Oct;266(4):372-89
19765181
J Cell Biol. 2001 Oct 1;155(1):123-31
11581289
Mol Pharm. 2009 May-Jun;6(3):895-904
19317416
Cell Cycle. 2010 May 15;9(10):1871-2
20436299
Development. 2009 Oct;136(19):3205-14
19736321
J Anat. 2003 Jan;202(1):59-68
12587921
J Clin Invest. 2010 Feb;120(2):403-7
20101091
Cell. 2007 Jun 1;129(5):999-1010
17540178
J Muscle Res Cell Motil. 2009 Dec;30(7-8):243-53
20195710
Muscle Nerve. 1982 Feb;5(2):152-61
7070396
Int J Biochem Cell Biol. 2007;39(3):469-77
17137828
Mol Biol Cell. 2007 Apr;18(4):1397-409
17287398
Semin Cell Dev Biol. 2007 Dec;18(6):870-82
18023213
Endocrinology. 1996 Apr;137(4):1385-94
8625915