title: Postdischarge secobarbital after ED migraine treatment decreases pain and improves resolution.
abstract: OBJECTIVE
  The objective of the study was to determine whether the addition of postdischarge oral secobarbital to standard emergency department (ED) migraine headache therapy improves pain relief and headache resolution compared with placebo.
  
  
  METHODS
  The setting is an urban ED with 70 000 yearly visits.
  
  
  METHODS
  This is an Institutional Review Board-approved, randomized, nonconsecutive, double-blinded, concealed, and placebo-controlled clinical trial. Patients with a clinical diagnosis of migraine underwent standard ED treatment and were discharged with 2 tablets of either secobarbital 100 mg or placebo. At home arrival, subjects recorded headache pain on a visual analog scale (VAS), took 1 tablet, and went to bed, taking the second tablet after 1 hour if not asleep. Upon awakening, subjects completed a second VAS and survey.
  
  
  METHODS
  The VAS data were analyzed using 2-tailed t test with unequal variance. Headache resolution data were analyzed using Fisher exact test.
  
  
  RESULTS
  Fifty subjects were enrolled. Complete data and follow-up were available for 30 subjects (60%). Fourteen subjects received placebo; 16 received secobarbital. Secobarbital subjects reported an average headache pain decrease of 25 mm (-13 to -38) compared with an average increase of 3 mm (-13 to 19) in the placebo group (P = .01). Ninety-four percent of the secobarbital group vs 50% of the placebo group had complete or partial headache resolution (P < .02). All subjects in the secobarbital group reported some relief.
  
  
  CONCLUSIONS
  Addition of postdischarge oral secobarbital to a standard ED migraine treatment regimen decreased headache pain at 24 hours after discharge and improved the rate of headache resolution compared with placebo.
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, TX, USA. robert.gerhardt@amedd.army.mil
authors.forename: Robert T
authors.initials: RT
authors.lastname: Gerhardt
authors.forename: Erik
authors.initials: E
authors.lastname: Hermstad
authors.forename: Donald M
authors.initials: DM
authors.lastname: Crawford
authors.forename: John
authors.initials: J
authors.lastname: Rayfield
authors.forename: James
authors.initials: J
authors.lastname: Pfaff
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Hunter
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D010351:Patient Discharge; D012631:Secobarbital / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006993:Hypnotics and Sedatives; D012631:Secobarbital