title: Ningbo thyroid dysfunction prevalence study: a cross-sectional survey in an employees-cohort.
abstract: BACKGROUND
  The prevalence and the spectrum of thyroid dysfunction in the mainland of China are not adequately understood. We performed a population-based study to determine the prevalence of major thyroid dysfunctions including overt and subclinical hyper- and hypothyroidism in a stable cohort.
  
  
  METHODS
  All active and retired employees aged 20 years and older (11 067) of Sinopec Zhenhai Refining & Chemical Company in Ningbo participated in the cross-sectional survey with a questionnaire and blood samples.
  
  
  RESULTS
  A total of 10 405 individuals attended for screening. Using biochemical definitions 95.5% were euthyroid. The prevalence of former diagnosed hyperthyroidism was 1.1% in females and 0.4% in males, hypothyroidism 1.7% and 0.3%, and thyroid surgery 1.2% and 0.3%, respectively. In both sex the prevalence increased with age. Twenty-four percent of individuals with thyroid surgery or medications had abnormal thyroid-stimulating hormone (TSH) levels. In individuals without a history of thyroid disease, the prevalence of pathological TSH values in females and males were TSH > or = 10 mU/L 0.60% and 0.29%; TSH 4.8-9.9 mU/L 5.71% and 2.25%; TSH < 0.3 mU/L 0.87% and 0.41%, respectively. Overt hyper- and hypothyroidism were uncommon (0.2%, 0.3%, respectively). The prevalence of subclinical hyper- and hypothyroidism was 0.4% and 3.4%, respectively. Subclinical hypothyroidism was more common in females (male 2.4% vs. female 5.8%, P < 0.001) and with increasing age (P < 0.001).
  
  
  CONCLUSIONS
  The prevalence of thyroid dysfunction is 4.5% in the cohort. Among individuals with thyroid medications or surgery, only 75.7% were within the normal range of TSH. These results indicate that thyroid dysfunction is common in Chinese adults.
authors.affiliation: Department of Endocrinology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Second Military Medical University, Shanghai 200003, China.
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Mao
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Liu
authors.forename: Chang-Xi
authors.initials: CX
authors.lastname: Chen
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Zhu
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology / Q000378:metabolism; D007037:Hypothyroidism / Q000453:epidemiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013959:Thyroid Diseases / Q000453:epidemiology* / Q000378:metabolism*; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000378:metabolism; D055815:Young Adult
chemical_list: D013972:Thyrotropin