title: Predictive value of middle cerebral artery to uterine artery pulsatility index ratio in preeclampsia.
abstract: OBJECTIVE
  To determine the predictive value of middle cerebral artery (MCA) to uterine artery pulsatility index (PI) ratio in preeclamptic patients.
  
  
  METHODS
  This prospective cross-sectional study was performed on 64 preeclamptic and 131 normal pregnancies at or beyond 26 weeks of gestation between June 2007-August 2008 in the high-risk pregnancy unit of Dr. Zekai Tahir Burak Women Health Teaching and Research Hospital, Ankara. Doppler blood flow velocimetry of the uterine and umbilical arteries and fetal MCA was measured. The ratios between the PI of MCA and the mean PI value of both uterine arteries were calculated and values below the fifth percentile were considered as brain-sparing. The ratios between the PI of MCA and PI of the umbilical artery were calculated and values lower than 1.08 were considered as brain-sparing and the results were related to perinatal outcome. Statistical analysis were performed using the SPSS Software (SPSS, Chicago, IL, USA) version 9.0 for Windows. Odds ratio with 95% confidence interval (95%) was also used for statistical analysis.
  
  
  RESULTS
  In 11 (42.3%) of the preeclamptic pregnancies that had abnormal MCA/uterine artery PI, 4 of them had severe preeclampsia and 7 had mild preeclampsia. In the low MCA/uterine artery PI ratio group, a statistically significantly higher rate of Cesarean section (66 vs. 88.46%), NICU admission (26.3 vs. 57.6%), preterm birth (52.6 vs. 92.3%) was found. Abnormal MCA/uterine artery PI ratio and abnormal MCA/umbilical artery PI ratio in the prediction of adverse outcome of pregnancy was compared. In the prediction of preterm birth, which was better for the MCA/uterine artery, there was a significant difference between the ratios (P = 0.005).
  
  
  CONCLUSIONS
  Our results suggest that MCA/uterine artery PI ratio is a good predictor of neonatal outcome in preeclamptic patients in the third trimester and could be used to identify fetuses at risk of morbidity and mortality.
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Dr. Zekai Tahir Burak Women Health Teaching and Research Hospital, 06100 Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Eser
authors.forename: Ebru
authors.initials: E
authors.lastname: Zulfıkaroglu
authors.forename: Suleyman
authors.initials: S
authors.lastname: Eserdag
authors.forename: Sevtap
authors.initials: S
authors.lastname: Kılıc
authors.forename: Nurı
authors.initials: N
authors.lastname: Danısman
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002585:Cesarean Section; D003430:Cross-Sectional Studies; D005260:Female; D005333:Fetus / Q000098:blood supply; D006801:Humans; D015931:Intensive Care, Neonatal; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000196:embryology / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D047928:Premature Birth; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology*; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055815:Young Adult