Development and evaluation of emulsions from Carapa guianensis (Andiroba) oil.
Carapa guianensis, a popular medicinal plant known as "Andiroba" in Brazil, has been used in traditional medicine as an insect repellent and anti-inflammatory product. Additionally, this seed oil has been reported in the literature as a repellent against Aedes aegypti. The aim of this work is to report on the emulsification of vegetable oils such as "Andiroba" oil by using a blend of nonionic surfactants (Span 80® and Tween 20®), using the critical hydrophilic-lipophilic balance (HLB) and pseudo-ternary diagram as tools to evaluate the system's stability. The emulsions were prepared by the inverse phase method. Several formulations were made according to a HLB spreadsheet design (from 4.3 to 16.7), and the products were stored at 25°C and 4°C. The emulsion stabilities were tested both long- and short-term, and the more stable one was used for the pseudo-ternary diagram study. The emulsions were successfully obtained by a couple of surfactants, and the HLB analysis showed that the required HLB of the oil was 16.7. To conclude, the pseudo-ternary diagram identified several characteristic regions such as emulsion, micro-emulsion, and separation of phases.
Ferreira
Magda R A
MR
Departamento de Farmácia-Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte-UFRN, Av. Coronel Gustavo Cordeiro de Farias, s/n, Petrópolis, 59010-180, Natal, Rio Grande do Norte, Brazil.
Santiago
Rosilene R
RR
de Souza
Tatiane P
TP
Egito
Eryvaldo S T
ES
Oliveira
Elquio E
EE
Soares
Luiz A L
LA
D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions / Q000138:chemical synthesis*; D006601:Hexoses / Q000737:chemistry*; D029582:Meliaceae / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry*
D004655:Emulsions; D006601:Hexoses; D010938:Plant Oils; D011136:Polysorbates; C018665:sorbitan monooleate
J Ethnopharmacol. 2008 Mar 28;116(3):495-500
18281172
J Am Mosq Control Assoc. 2004 Dec;20(4):456-7
15669392
AAPS PharmSciTech. 2006 Mar;7(1):E146-E152
28290036
J Colloid Interface Sci. 2000 Oct 1;230(1):213-215
10998309
Int J Cosmet Sci. 2007 Jun;29(3):211-8
18489351
AAPS PharmSciTech. 2007 Nov 02;8(4):E91
18181551
Int J Pharm. 2002 Apr 26;237(1-2):241-9
11955821
Adv Drug Deliv Rev. 2000 Dec 6;45(1):89-121
11104900
Inflamm Res. 2006 Nov;55(11):457-64
17122962
J Ethnopharmacol. 2007 May 30;112(1):122-6
17368776
Rev Inst Med Trop Sao Paulo. 2004 Sep-Oct;46(5):253-6
15517027
Int J Pharm. 2007 Nov 1;344(1-2):158-60
17614224
Adv Colloid Interface Sci. 2004 May 20;108-109:259-72
15072945
J Ethnopharmacol. 1993 Sep;40(1):53-75
8246531
Adv Colloid Interface Sci. 2004 May 20;108-109:227-58
15072944
AAPS PharmSciTech. 2006 May 12;7(2):E45
16796362
J Am Mosq Control Assoc. 2006 Dec;22(4):699-701
17304939
Fitoterapia. 2005 Dec;76(7-8):629-36
16253435