title: International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease.
abstract: The International Society of Urological Pathology Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to extraprostatic extension (pT3a disease), bladder neck invasion, lymphovascular invasion and the definition of pT4 were coordinated by working group 3. It was agreed that prostate cancer can be categorized as pT3a in the absence of adipose tissue involvement when cancer bulges beyond the contour of the gland or beyond the condensed smooth muscle of the prostate at posterior and posterolateral sites. Extraprostatic extension can also be identified anteriorly. It was agreed that the location of extraprostatic extension should be reported. Although there was consensus that the amount of extraprostatic extension should be quantitated, there was no agreement as to which method of quantitation should be employed. There was overwhelming consensus that microscopic urinary bladder neck invasion by carcinoma should be reported as stage pT3a and that lymphovascular invasion by carcinoma should be reported. It is recommended that these elements are considered in the development of practice guidelines and in the daily practice of urological surgical pathology.
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic & Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA. MAGIC@ccf.org
authors.forename: Cristina
authors.initials: C
authors.lastname: Magi-Galluzzi
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Evans
authors.forename: Brett
authors.initials: B
authors.lastname: Delahunt
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
authors.forename: David F
authors.initials: DF
authors.lastname: Griffiths
authors.forename: Theo H
authors.initials: TH
authors.lastname: van der Kwast
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Wheeler
authors.forename: John R
authors.initials: JR
authors.lastname: Srigley
authors.forename: Lars L
authors.initials: LL
authors.lastname: Egevad
authors.forename: Peter A
authors.initials: PA
authors.lastname: Humphrey
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology* / Q000601:surgery; D001900:Boston; D006801:Humans; D038622:Internationality; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D012955:Societies, Medical; D013048:Specimen Handling / Q000379:methods*; D001743:Urinary Bladder / Q000473:pathology