title: Stereoselective construction of a steroid 5α,7α-oxymethylene derivative and its use in the synthesis of eplerenone.
abstract: A new and practical method for a stereoselective construction of a steroid 5α,7α-oxymethylene derivative has been developed and successfully applied to the stereoselective synthesis of eplerenone (8). Starting with available 11α-hydroxyl canrenone (1), eplerenone (8) was synthesised in seven steps with a 48% overall yield.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Hongli
authors.initials: H
authors.lastname: Chen
authors.forename: Huijin
authors.initials: H
authors.lastname: Feng
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000077545:Eplerenone; D008968:Molecular Conformation; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D013148:Spironolactone; D000077545:Eplerenone