Stemming vision loss with stem cells.
Dramatic advances in the field of stem cell research have raised the possibility of using these cells to treat a variety of diseases. The eye is an excellent target organ for such cell-based therapeutics due to its ready accessibility, the prevalence of vasculo- and neurodegenerative diseases affecting vision, and the availability of animal models to demonstrate proof of concept. In fact, stem cell therapies have already been applied to the treatment of disease affecting the ocular surface, leading to preservation of vision. Diseases in the back of the eye, such as macular degeneration, diabetic retinopathy, and inherited retinal degenerations, present greater challenges, but rapidly emerging stem cell technologies hold the promise of autologous grafts to stabilize vision loss through cellular replacement or paracrine rescue effects.
Marchetti
Valentina
V
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.
Krohne
Tim U
TU
Friedlander
David F
DF
Friedlander
Martin
M
D000818:Animals; D004195:Disease Models, Animal; D005123:Eye / Q000033:anatomy & histology / Q000473:pathology; D006801:Humans; D008268:Macular Degeneration / Q000628:therapy*; D012162:Retinal Degeneration / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*
Cell Stem Cell. 2009 Oct 2;5(4):396-408
19796620
Arch Ophthalmol. 2008 Feb;126(2):227-32
18268214
Science. 2006 Mar 31;311(5769):1880-5
16574858
Arch Ophthalmol. 2003 Jan;121(1):132-3
12523905
N Engl J Med. 2006 Oct 5;355(14):1419-31
17021318
Curr Stem Cell Res Ther. 2007 Dec;2(4):301-9
18220914
Blood. 2004 May 1;103(9):3420-7
14726407
Trends Pharmacol Sci. 2010 Jan;31(1):36-45
19896224
Angiogenesis. 2007;10(2):133-40
17332988
Exp Gerontol. 2005 Aug-Sep;40(8-9):745-8
16051457
J Clin Invest. 2004 Sep;114(6):765-74
15372100
Gene Ther. 2002 Jun;9(11):754-8
12032704
PLoS One. 2008 Apr 30;3(4):e2078
18446208
Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3595-602
16877434
Exp Neurol. 2008 Dec;214(2):347-61
18926821
Science. 1997 Feb 14;275(5302):964-7
9020076
Science. 2000 Mar 17;287(5460):2032-6
10720333
Br J Ophthalmol. 2002 Feb;86(2):174-80
11815343
Blood. 1999 Dec 1;94(11):3928-40
10572110
Science. 2003 Feb 7;299(5608):890-3
12574630
Science. 2009 May 8;324(5928):797-801
19325077
Surv Ophthalmol. 1977 Sep-Oct;22(2):88-100
335549
Cell Stem Cell. 2010 Jun 4;6(6):504-5
20578343
Ophthalmology. 1995 Oct;102(10):1476-85
9097795
Invest Ophthalmol Vis Sci. 1998 May;39(6):1021-7
9579482
N Engl J Med. 2004 Sep 16;351(12):1187-96
15371576
Nat Biotechnol. 2008 Jan;26(1):101-6
18059259
Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1186-92
15498828
Ann Hematol. 2009 Jun;88(6):581-8
19030858
Atherosclerosis. 2005 Aug;181(2):285-93
16039282
Graefes Arch Clin Exp Ophthalmol. 1989;227(1):72-7
2920910
Acta Neurobiol Exp (Wars). 2007;67(4):359-65
18320714
Prog Retin Eye Res. 2003 Sep;22(5):607-55
12892644
Stem Cells Dev. 2009 Apr;18(3):399-409
18665766
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):178-83
11773625
Stem Cells. 2010 Apr;28(4):695-703
20166150
Cloning Stem Cells. 2004;6(3):217-45
15671670
J Comp Neurol. 2010 Mar 1;518(5):636-46
20034055
Blood. 2005 Oct 1;106(7):2347-55
15985545
Circ Res. 2003 Nov 14;93(10):980-9
14525810
Blood. 2005 Mar 15;105(6):2400-2
15572598
Mol Ther. 2009 Sep;17(9):1594-604
19584817
J Public Health (Oxf). 2005 Dec;27(4):348-52
16234264
Stem Cells. 2006 Dec;24(12):2868-76
16902198
N Engl J Med. 2006 Oct 5;355(14):1474-85
17021323
PLoS One. 2007 Mar 28;2(3):e338
17396165
Nat Med. 2001 Apr;7(4):430-6
11283669
Ophthalmology. 2007 Mar;114(3):551-60
17324697
Eur J Ophthalmol. 1999 Jul-Sep;9(3):217-30
10544978
Arch Ophthalmol. 2004 Apr;122(4):598-614
15078679
Cornea. 2000 May;19(3):378-83
10832703
Arch Ophthalmol. 2004 Apr;122(4):477-85
15078664
Nat Protoc. 2009;4(6):811-24
19444239
Trends Immunol. 2004 Dec;25(12):677-86
15530839
Mol Vis. 2006 Jul 12;12:774-90
16862071
Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4914-9
14578417
J Cell Biol. 1986 Jul;103(1):49-62
2424919
Neurosci Lett. 2009 Jul 24;458(3):126-31
19379795
Arch Ophthalmol. 2004 Apr;122(4):564-72
15078675
Acta Paediatr Jpn. 1994 Dec;36(6):649-55
7871975
Circ Res. 2001 Feb 2;88(2):167-74
11157668
Circulation. 2004 Mar 16;109(10):1215-8
15007007
PLoS One. 2009 Dec 03;4(12):e8152
19997644
Stem Cells. 2010 Mar 31;28(3):489-500
20014120
Cell Stem Cell. 2009 Jun 5;4(6):472-6
19481515
Science. 2008 Dec 5;322(5907):1498-501
19056975
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16698-703
19706890
Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1301-14
1694836
Am J Ophthalmol. 2010 May;149(5):800-6.e1
20189158
Curr Stem Cell Res Ther. 2008 Dec;3(4):229-36
19075753
J Cell Sci. 2009 Sep 1;122(Pt 17):3169-79
19671662
Mol Vis. 2009;15:283-95
19204785
Stem Cells. 2009 Dec;27(12):2992-3000
19839055
Invest Ophthalmol Vis Sci. 2007 Feb;48(2):597-604
17251455
Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4908-13
14578416
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5970-8
20484577
J Clin Invest. 2006 Dec;116(12):3266-76
17111048
Stem Cells. 2009 Mar;27(3):642-52
19074417
Eye (Lond). 1989;3 ( Pt 6):719-26
2630352
Invest Ophthalmol Vis Sci. 2003 Jan;44(1):106-16
12506062
Stem Cells. 2006 Jun;24(6):1594-604
16556707
Biochem Biophys Res Commun. 2009 Mar 6;380(2):230-5
19167364
Trends Immunol. 2002 Nov;23(11):549-55
12401408
Exp Eye Res. 2006 Jun;82(6):959-67
16310191
Exp Eye Res. 2008 Jun;86(6):957-65
18472095
N Engl J Med. 2006 Oct 5;355(14):1432-44
17021319
Science. 2000 Dec 1;290(5497):1779-82
11099419
Nature. 2006 Nov 9;444(7116):203-7
17093405
Cloning Stem Cells. 2006 Fall;8(3):189-99
17009895
Blood. 2004 Oct 1;104(7):2010-9
15213103
Biochem Biophys Res Commun. 2005 Jan 21;326(3):578-85
15596138
Stem Cells. 2009 Oct;27(10):2427-34
19658190
Science. 2002 Oct 11;298(5592):361-2; author reply 362-3
12392027
Nature. 2008 Nov 13;456(7219):250-4
18830243
Bull World Health Organ. 2004 Nov;82(11):844-51
15640920
Nat Med. 2002 Jun;8(6):607-12
12042812
Invest Ophthalmol Vis Sci. 2006 Mar;47(3):909-16
16505023
Transplantation. 2001 Nov 15;72(9):1478-85
11707733
Pediatr Res. 2006 Apr;59(4 Pt 2):26R-32R
16549545
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6685-90
19346468
Am J Ophthalmol. 1989 Jan 15;107(1):1-6
2912110
Science. 2000 Feb 25;287(5457):1442-6
10688785
Angiogenesis. 2003;6(4):283-7
15166496
Exp Hematol. 1988 Sep;16(8):660-6
3261250
N Engl J Med. 2010 Jul 8;363(2):147-55
20573916
Exp Eye Res. 2009 Apr;88(4):747-51
19061887
Ophthalmology. 1989 May;96(5):709-22; discussion 722-3
2748125
Bone Marrow Transplant. 2001 May;27(10):1081-6
11438825
Cell. 2007 Nov 30;131(5):861-72
18035408
Stem Cells. 2010 Mar 31;28(3):597-610
20014040
Ophthalmology. 1984 Jun;91(6):564-79
6462622
Science. 2010 Jan 29;327(5965):542-5
20110496
Stem Cells. 2009 Mar;27(3):577-605
19056906
Exp Hematol. 2008 Jun;36(6):672-80
18358589
Physiol Rev. 2005 Jul;85(3):845-81
15987797
Stem Cells. 2006 Feb;24(2):246-57
16123388
N Engl J Med. 1999 Jun 3;340(22):1697-703
10352161
Cell Stem Cell. 2008 Oct 9;3(4):382-8
18940730
Ann Thorac Surg. 2000 Sep;70(3):829-34
11016318
J Clin Invest. 2009 Mar;119(3):611-23
19188685
Nat Med. 2002 Sep;8(9):1004-10
12145646
Science. 2007 Dec 21;318(5858):1917-20
18029452