title: Right man, right time, right place?--on the time course of the mediator orchestra in septic shock.
abstract: Appropriate timing of treatment assumes particular importance in critical care. Lange and colleagues recently reported on the time course of the different nitric oxide synthase (NOS) isoforms, nitrosative stress, and poly(ADP-ribosylation) during Pseudomonas aeruginosa pneumonia-induced ovine septic shock. Initially, endothelial NOS expression was increased together with markers of peroxynitrite formation, DNA damage, and nuclear factor-kappa-B activation. Later on, measurable NOS activity and nitric oxide production resulted mainly from inducible NOS activation. These results emphasize the need for long-term, large-animal studies investigated over days so that future therapeutic interventions can be better tailored and matched to the exact time course of the activation of the mediator orchestra.
authors.affiliation: Aneszteziológiai és Intenzív Terápiás Klinika, Semmelweis University, H-1125 Budapest, Kútvölgyi út 4, Hungary. bhauser1@gmail.com
authors.forename: Balázs
authors.initials: B
authors.lastname: Hauser
authors.forename: Peter
authors.initials: P
authors.lastname: Radermacher
mesh_terms: D000818:Animals; D003422:Critical Care / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D019001:Nitric Oxide Synthase / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012772:Shock, Septic / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D017382:Reactive Oxygen Species; D019001:Nitric Oxide Synthase
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