The rise and fall of horror autotoxicus and forbidden clones.
Cui and associates show that healthy individuals have natural autoantibodies (NAAs) specific for myeloperoxidase, proteinase 3, and glomerular basement membrane (GBM) with the same specificity as anti-neutrophil cytoplasmic antibodies and anti-GBM antibodies that are pathogenic. Although Ehrlich proposed horror autotoxicus and Burnet envisioned elimination of forbidden clones, NAAs are present in all healthy individuals and play beneficial homeostatic roles. Pathogenic autoimmunity is dysregulation of natural homeostatic autoimmunity rather than onset of a previously absent self-recognition.
Jennette
J Charles
JC
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7525, USA. jcj@med.unc.edu
Falk
Ronald J
RJ
D001323:Autoantibodies / Q000502:physiology*; D015551:Autoimmunity / Q000502:physiology; D050533:Glomerular Basement Membrane / Q000276:immunology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D053146:Myeloblastin / Q000276:immunology; D009195:Peroxidase / Q000276:immunology
D001323:Autoantibodies; D009195:Peroxidase; D053146:Myeloblastin