title: Primary Spindle Cell Sarcoma of the Breast.
abstract: BACKGROUND: Primary pure breast sarcoma is a rare disease and constitutes 0.2-1.0% of all mammary malignancies. The establishment of a diagnosis of soft tissue sarcoma is difficult in adults. Immunohistochemical analysis usually proves to be helpful in indistinguishable cases. The simplistic step is to classify sarcomas on a simple descriptive basis as spindle cell sarcomas, myxoid sarcomas, pleomorphic sarcomas, and small round cell sarcomas. CASE REPORT: Here, we present a rare case of primary spindle cell sarcoma of the breast. A 43-year-old woman was admitted to our clinic with a 2-month history of a left breast lump. Histopathological examination showed a tumor of 2.5 cm in diameter and of nuclear and histological grade 2. In the immunohistochemical examination, vimentin positivity, high nuclear overexpression of P53, high Ki-67 and S-100, desmin, leukocyte common antigen, keratin, and smooth muscle antigen, CD34, HMB45 and EMA negativity were detected. CONCLUSION: Most invasive breast neoplasms are epithelial tumors, and mesenchymal breast tumors are rarely seen. In primary breast sarcoma, adequate surgical tumor excision, tumor grade, and tumor diameter seem to be the most important prognostic factors.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Diyarbakir, Turkey.
authors.forename: Timucin
authors.initials: T
authors.lastname: Cil
authors.forename: Abdullah
authors.initials: A
authors.lastname: Altintas
authors.forename: Semir
authors.initials: S
authors.lastname: Pasa
authors.forename: Huseyin
authors.initials: H
authors.lastname: Buyukbayram
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Isikdogan
references.citation: J Clin Oncol. 2003 Jul 1;21(13):2583-8
references.pmid: 12829679
references.citation: J Surg Oncol. 2004 Sep 1;87(3):121-5
references.pmid: 15334638
references.citation: Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):383-90
references.pmid: 10661345
references.citation: Eur J Surg Oncol. 1988 Jun;14(3):241-7
references.pmid: 2836236
references.citation: Cancer. 2005 Aug 15;104(4):856-63
references.pmid: 15981282
references.citation: Geburtshilfe Frauenheilkd. 1993 Nov;53(11):811-3
references.pmid: 8293949
references.citation: Surg Clin North Am. 1996 Apr;76(2):383-92
references.pmid: 8610270
references.citation: Am J Surg. 2003 Oct;186(4):359-61
references.pmid: 14553850
references.citation: Cancer. 1962 Mar-Apr;15:418-24
references.pmid: 13867580
references.citation: Ann Surg. 1985 Apr;201(4):527-32
references.pmid: 3977455
references.citation: Int J Radiat Oncol Biol Phys. 1993 Oct 20;27(3):671-5
references.pmid: 8226163
references.citation: Cancer. 1990 Sep 1;66(5):941-4
references.pmid: 2386920
references.citation: Pathol Res Pract. 1984 Jan;178(3):215-26
references.pmid: 6326068