Inflammatory mediators gene polymorphisms in preeclampsia.
OBJECTIVE
To assess a possible relation between proinflammatory mediators (IL-1R1, IL-12, IL-18, TLR-2, and TLR-4) gene polymorphisms and preeclampsia (PE).


METHODS
Genotyping was performed on 109 preeclamptic patients and 174 healthy fertile women with at least two previous successful pregnancies (controls). χ(2) or Fisher's exact test were used to compare genotype frequencies. The control group included 174 pregnant women matched by race to the study group.


RESULTS
Genotypic and allelic distributions for all six polymorphisms were similar between the study and control groups. IL-1R1 (PstI, rs2234650): p = 0.82 ; IL-12 (+1188, rs3212227): p = 0.93; IL-18 (-137, rs187238): p = 0.74 ; IL-18 (-607, rs1946519): p = 0.22; TLR-2 (+2258, rs5743708): p = 0.97; and TLR-4 (+896, rs4986790): p = 0.23.


CONCLUSIONS
The analyzed gene polymorphisms are not associated with PE.
Franchim
Camila S
CS
Department of Obstetrics, Sao Paulo Federal University, Sao Paulo, Brazil.
Sass
Nelson
N
Mattar
Rosiane
R
Pendeloski
Karen P T
KP
Lin
Lawrence Hsu
LH
Torloni
Maria R
MR
Daher
Silvia
S
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D018836:Inflammation Mediators; D018664:Interleukin-12 / Q000235:genetics*; D020382:Interleukin-18 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
D018836:Inflammation Mediators; D020382:Interleukin-18; D017472:Receptors, Interleukin-1; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D018664:Interleukin-12