title: Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.
abstract: Little is known about the role of GABA(B) receptors (GABA(B)Rs) in the maintenance of memories associated with using abused substances. We have embarked on a series of studies designed to determine if enhancing the efficacy of GABA-occupied GABA(B)Rs with positive allosteric modulators (PAMs) can negate previously established conditioned place preference (CPP) induced by methamphetamine. In the current study, we evaluated the effects of acute administration of GABA(B)R PAMs, GS39783 and CGP7930. We determined that post-conditioning treatments with these PAMs, administered in the home cage, blocked the subsequent expression of methamphetamine-induced CPP. These data indicate that selectively augmenting GABA-occupied GABA(B)R signaling is sufficient to reduce memory maintenance and/or the salience of contextual cues previously associated with methamphetamine.
authors.affiliation: Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, United States. rvoigt@lumc.edu
authors.forename: Robin M
authors.initials: RM
authors.lastname: Voigt
authors.forename: Amy A
authors.initials: AA
authors.lastname: Herrold
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Riddle
authors.forename: T Celeste
authors.initials: TC
authors.lastname: Napier
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D003213:Conditioning, Psychological / Q000187:drug effects*; D003517:Cyclopentanes / Q000494:pharmacology; D058786:GABA-B Receptor Agonists / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D010636:Phenols / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C438607:2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol; D000697:Central Nervous System Stimulants; D003517:Cyclopentanes; D058786:GABA-B Receptor Agonists; C478058:N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine; D010636:Phenols; D011743:Pyrimidines; D008694:Methamphetamine
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