Nicolau syndrome: an iatrogenic cutaneous necrosis.
Nicolau syndrome is an uncommon complication of intramuscular injection leading to variable degrees of necrosis of skin and the underlying tissues. We report here two cases of this syndrome. Our first case was a 25 year-old male who developed intense pain and purplish discoloration of the skin in the right hip after intramuscular diclofenac injection. The second case was a 60 year-old male who developed intense pain and discoloration of skin, not only at the injection site, but also on the left scapular area and left elbow after receiving chlorpheniramine maleate injection intramuscularly. These cases highlight the need for awareness about this condition and the need to exercise utmost care during the administration of any parenteral injections by dermatologists.
Nischal
Kc
K
Department of Dermatology, Adichunchanagiri Institute of Medical Sciences, BG Nagar, Karnataka, India.
Basavaraj
Hb
H
Swaroop
Mr
M
Agrawal
Dp
D
Sathyanarayana
Bd
B
Umashankar
Np
N
Clin Exp Dermatol. 2008 Aug;33(5):555-8
18627396
Int J Dermatol. 2006 Nov;45(11):1326-8
17076716
Eur J Dermatol. 1999 Mar;9(2):132-3
10066964
J Orthop Surg (Hong Kong). 2006 Apr;14(1):104-7
16598099
Acta Orthop Belg. 2008 Dec;74(6):860-4
19205337
J Postgrad Med. 2008 Oct-Dec;54(4):332-4
18953160
Hautarzt. 2005 Oct;56(10):968-9
16142495
J Burn Care Res. 2006 Jul-Aug;27(4):541-4
16819362
Eur J Pediatr. 2009 Dec;168(12):1541-2
19277707
J Dtsch Dermatol Ges. 2007 Dec;5(12):1122-3
18042092
Joint Bone Spine. 2003 Sep;70(5):390-2
14563471
J Eur Acad Dermatol Venereol. 2001 Nov;15(6):585-8
11843224
Int J Dermatol. 2005 Dec;44(12):1069-70
16409285
Plast Reconstr Surg. 2003 Dec;112(7):1970-1
14663268
J Dermatol. 2008 Jan;35(1):18-20
18181770
Praxis (Bern 1994). 2006 Sep 27;95(39):1499-503
17061464
Z Hautkr. 1985 Oct 15;60(20):1639-45
2932865
J Drugs Dermatol. 2006 Apr;5(4):377-8
16673810
Acta Derm Venereol. 2005;85(4):372-3
16191871