title: Comparison of cancer care for hepatocellular carcinoma at two tertiary-care referral centers from high and low endemic regions for viral hepatitis.
abstract: BACKGROUND
  Risk factors for hepatocellular carcinoma (HCC) have geographic variability but differences in care have not been described. We reviewed the presentation, management, and outcomes of HCC patients from two tertiary-referral centers in Central Saudi Arabia and Atlantic Canada during 1997-2002.
  
  
  METHODS
  Data were extracted from health records of 96 Saudi and 80 Canadian consecutive patients with HCC.
  
  
  RESULTS
  Mean age (± SEM) of the two groups were similar (64 + 1 and 65 + 1 years) with 93% versus 75% males amongst Canadian and Saudi patients, respectively. In Canada, underlying disease was alcohol-related cirrhosis (45%), cryptogenic cirrhosis (26%), or hepatitis C (13%). For Saudis, HCC cases were attributed to hepatitis C (47%), cryptogenic cirrhosis (27%), and hepatitis B (21%). At initial presentation, Saudi patients had more vascular invasion and distant metastases while Canadians had more advanced liver disease. The tumor-specific prognostic classifications were comparable. Due to center-specific expertise or preference, symptomatic treatment was more common amongst Saudi patients (83% versus 42%) while more Canadians underwent local palliative interventions (52% versus 12%). Frequency of potentially curative therapies including resection and transplantation were similar at both centers. There was no difference in overall median survival (14 versus 10 months) amongst Canadian and Saudi patients.
  
  
  CONCLUSIONS
  This study validates divergence in HCC presentation between low and high endemic regions for viral hepatitis. In addition, for the first time, differences in cancer care of HCC are documented.
authors.affiliation: Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: Fahad
authors.initials: F
authors.lastname: Alsohaibani
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Porter
authors.forename: Hamad
authors.initials: H
authors.lastname: Al-Ashgar
authors.forename: Mark
authors.initials: M
authors.lastname: Walsh
authors.forename: Robert
authors.initials: R
authors.lastname: Berry
authors.forename: Michele
authors.initials: M
authors.lastname: Molinari
authors.forename: Kevork Minas
authors.initials: KM
authors.lastname: Peltekian
mesh_terms: D000368:Aged; D002173:Cancer Care Facilities; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification; D006509:Hepatitis B / Q000150:complications* / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology / Q000821:virology; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000473:pathology / Q000821:virology; D008113:Liver Neoplasms / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D005791:Patient Care; D011379:Prognosis; D015996:Survival Rate
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