title: Tick-borne meningoencephalitis in a 4.5-month-old infant.
abstract: BACKGROUND
  The course of tick-borne encephalitis (TBE) in children is supposed to be mild though severe neurological sequelae have been reported. Only occasionally infants are affected.
  
  
  METHODS
  Case report, review of literature.
  
  
  RESULTS
  We describe the first case of tick-borne encephalitis in a 4.5-month-old male infant in Germany. 11 days after a tick-bite he developed acute illness with fever, focal and generalized seizures. Meningoencephalitis caused by the TBE virus was diagnosed by cerebrospinal fluid (CSF) pleocytosis and detection of TBE-RNA in the CSF. Neurological follow-up showed no abnormalities.
  
  
  CONCLUSIONS
  The acute meningoencephalitis in the present case and the neurological short and long term morbidity of 3 additional published cases of TBE suggest the considerable burden of this disease in infancy. As parents can transmit the tick to their infant informations about exposure-prophylactic measurements are recommended.
authors.affiliation: Pediatrics, Medical Center Coburg, Ketschendorferstraße 33, Coburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Leistner
authors.forename: P
authors.initials: P
authors.lastname: Dahlem
mesh_terms: D000818:Animals; D001733:Bites and Stings / Q000150:complications; D003937:Diagnosis, Differential; D004675:Encephalitis, Tick-Borne / Q000175:diagnosis* / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D012307:Risk Factors; D012640:Seizures / Q000209:etiology; D013987:Ticks