title: Posterior versus anterior circulation strokes: comparison of clinical, radiological and outcome characteristics.
abstract: OBJECTIVE
  Physicians treating patients with posterior circulation strokes (PCS) tended to debate more on whether or not to introduce anticoagulation rather than performing investigations to identify stroke aetiology, as in patients with anterior circulation strokes (ACS). Recent findings suggest that stroke aetiologies of PCS and ACS are more alike than dissimilar, suggesting that PCS deserve the same investigations as ACS. The characteristics and current diagnostic evaluation between patients with PCS and ACS were compared.
  
  
  METHODS
  312 consecutive patients with first ever ACS and 93 patients with first ever PCS were prospectively analysed.
  
  
  RESULTS
  Patients with ACS and PCS did not differ in terms of demographic characteristics, prevalence of vascular risk factors, diagnostic evaluation or stroke aetiology. The median National Institutes of Health Stroke Scale score was 8 in ACS and 4 in PCS (p=0.004). Brain imaging revealed more often pathological findings in ACS than PCS. The proportion of non-thrombolysed patients with a favourable clinical outcome (modified Rankin score 0-2) was similar in ACS and PCS (67.0% vs 78.4%; p=0.08). In non-thrombolysed patients, stroke severity was an independent predictor of clinical outcome both in ACS (OR 1.60, 95% CI 1.2 to 2.1; p<0.0001) and in PCS (OR 1.22, 95% CI 1.03 to 1.44; p=0.02) while age predicted poor outcome only in ACS (OR 1.11, 95% CI 1.01 to 1.22; p=0.007). In thrombolysed patients, stroke severity was the only outcome predictor in ACS (OR 1.14, 95% CI 1.04 to 1.25; p=0.004) while we identified no statistically relevant predictor of PCS outcome.
  
  
  CONCLUSIONS
  In PCS and ACS, baseline variables, aetiology and outcome are more alike than different.
authors.affiliation: Department of Neurology, University of Bern, Bern, Switzerland. gianmarcodemarchis@me.com
authors.forename: Gian Marco
authors.initials: GM
authors.lastname: De Marchis
authors.forename: Adrian
authors.initials: A
authors.lastname: Kohler
authors.forename: Nora
authors.initials: N
authors.lastname: Renz
authors.forename: Marcel
authors.initials: M
authors.lastname: Arnold
authors.forename: Marie-Luise
authors.initials: ML
authors.lastname: Mono
authors.forename: Simon
authors.initials: S
authors.lastname: Jung
authors.forename: Urs
authors.initials: U
authors.lastname: Fischer
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Karameshev
authors.forename: Caspar
authors.initials: C
authors.lastname: Brekenfeld
authors.forename: Jan
authors.initials: J
authors.lastname: Gralla
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schroth
authors.forename: Heinrich P
authors.initials: HP
authors.lastname: Mattle
authors.forename: Krassen
authors.initials: K
authors.lastname: Nedeltchev
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D020771:Anterior Cerebral Artery / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020769:Posterior Cerebral Artery / Q000473:pathology*; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D012959:Socioeconomic Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D015912:Thrombolytic Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome