Modulation of autoimmunity with artificial peptides.
The loss of immune tolerance to self antigens leads to the development of autoimmune responses. Since self antigens are often multiple and/or their sequences may be known, one approach to restore immune tolerance uses synthetic artificial peptides that interfere or compete with self peptides in the networks of cellular interactions that drive the autoimmune process. This review describes the rationale behind the use of artificial peptides in autoimmunity and their mechanisms of action. Examples of use of artificial peptides in preclinical studies and in the management of human autoimmune diseases are provided.
La Cava
Antonio
A
Division of Rheumatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. alacava@mednet.ucla.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity / Q000187:drug effects*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D010455:Peptides / Q000276:immunology / Q000494:pharmacology*
D010455:Peptides
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