Clinical impact of a highly prevalent Pseudomonas aeruginosa clone in Dutch cystic fibrosis patients.
Studies suggest that infection with highly prevalent Pseudomonas aeruginosa clones in cystic fibrosis (CF) is associated with an unfavourable clinical outcome. We studied the clinical characteristics of patients infected with a recently described, highly prevalent P. aeruginosa clone (ST406) in two CF centres in The Netherlands. Multilocus sequence typing data were available for 219 patients, of whom 40 (18.3%) were infected with ST406 and 179 with other sequence types. ST406 infection was independently associated with age, having a sibling with ST406 infection and use of inhaled antibiotics, but not with unfavourable clinical outcome, suggesting that high transmissibility is not necessarily associated with high virulence.
de Vrankrijker
A M M
AM
Department of Paediatric Respiratory Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands. a.m.m.devrankrijker@umcutrecht.nl
Brimicombe
R W
RW
Wolfs
T F W
TF
Heijerman
H G M
HG
van Mansfeld
R
R
van Berkhout
F T
FT
Willems
R J L
RJ
Bonten
M J M
MJ
van der Ent
C K
CK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D058885:Multilocus Sequence Typing; D009426:Netherlands / Q000453:epidemiology; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000235:genetics*; D035781:Siblings; D055815:Young Adult