Thymoma with nuclear expression of thyroid transcription factor-1: a potential diagnostic pitfall on core biopsy.
The clinicopathologic features of the first case of a thymoma with a strong nuclear expression of thyroid transcription factor-1 are reported. The thymoma was classified as type AB according to the WHO-system. No definitive correlation between the different histologic patterns or neoplastic cell types and thyroid transcription factor-1 expression was discerned. No immunohistochemical evidence of neuroendocrine differentiation was identified with synaptophysin, chromogranin A, and CD56.
Yan
Benedict
B
Department of Pathology, National University Hospital Systems, Singapore.
Seng
Sim Chee
SC
Petersson
Fredrik
F
D000943:Antigens, Differentiation / Q000378:metabolism; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis*; D013953:Thymus Neoplasms / Q000378:metabolism / Q000473:pathology; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000096:biosynthesis*
D000943:Antigens, Differentiation; C000614412:NKX2-1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors