title: Contribution of chitinases to Listeria monocytogenes pathogenesis.
abstract: Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.
authors.affiliation: UIC Department of Microbiology and Immunology (MC790), 835 S. Wolcott Ave., Chicago, IL 60612-7344, USA.
authors.forename: Swarnava
authors.initials: S
authors.lastname: Chaudhuri
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Bruno
authors.forename: Francis
authors.initials: F
authors.lastname: Alonzo
authors.forename: Bobbi
authors.initials: B
authors.lastname: Xayarath
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Cianciotto
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Freitag
mesh_terms: D000818:Animals; D018938:Caco-2 Cells / Q000382:microbiology; D002686:Chitin / Q000378:metabolism; D002688:Chitinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008089:Listeria monocytogenes / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D008088:Listeriosis / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000382:microbiology
chemical_list: D002686:Chitin; D002688:Chitinases
references.citation: Curr Top Microbiol Immunol. 2009;337:173-95
references.pmid: 19812983
references.citation: FEMS Immunol Med Microbiol. 2008 Jul;53(2):151-65
references.pmid: 18462388
references.citation: Nat Rev Microbiol. 2009 Sep;7(9):623-8
references.pmid: 19648949
references.citation: Microbes Infect. 2007 Aug;9(10):1236-43
references.pmid: 17720602
references.citation: MMWR Morb Mortal Wkly Rep. 2004 Apr 30;53(16):338-43
references.pmid: 15123986
references.citation: Epidemiol Infect. 2006 Aug;134(4):744-51
references.pmid: 16318652
references.citation: Nature. 2005 Dec 8;438(7069):863-6
references.pmid: 16341015
references.citation: Int J Med Microbiol. 2001 May;291(2):145-57
references.pmid: 11437337
references.citation: Appl Environ Microbiol. 2010 Oct;76(19):6470-6
references.pmid: 20675445
references.citation: MMWR Morb Mortal Wkly Rep. 2009 Apr 10;58(13):333-7
references.pmid: 19357633
references.citation: J Bacteriol. 2002 Aug;184(15):4177-86
references.pmid: 12107135
references.citation: J Bacteriol. 2009 Nov;191(22):6911-7
references.pmid: 19734310
references.citation: Clin Microbiol Infect. 2010 Jan;16(1):16-23
references.pmid: 20002687
references.citation: Infect Immun. 1990 Nov;58(11):3770-8
references.pmid: 2172168
references.citation: Infect Immun. 2006 Feb;74(2):1323-38
references.pmid: 16428782
references.citation: Infect Immun. 2009 Jul;77(7):2612-23
references.pmid: 19451247
references.citation: Trends Parasitol. 2003 Jul;19(7):305-11
references.pmid: 12855381
references.citation: J Appl Microbiol. 2009 Dec 1;107(6):2080-7
references.pmid: 19583793
references.citation: Anim Health Res Rev. 2005 Dec;6(2):211-7
references.pmid: 16583783
references.citation: Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19146-51
references.pmid: 17148602
references.citation: Clin Microbiol Rev. 2001 Jul;14(3):584-640
references.pmid: 11432815
references.citation: Infect Immun. 2008 Nov;76(11):4968-77
references.pmid: 18765724
references.citation: Trends Microbiol. 2008 Aug;16(8):388-96
references.pmid: 18619843
references.citation: MMWR Morb Mortal Wkly Rep. 1998 Dec 25;47(50):1085-6
references.pmid: 9883769
references.citation: MMWR Morb Mortal Wkly Rep. 1999 Jan 8;47(51-52):1117-8
references.pmid: 9921730
references.citation: Appl Environ Microbiol. 2008 Jun;74(12):3823-30
references.pmid: 18424542
references.citation: Crit Rev Food Sci Nutr. 2009 Mar;49(3):237-53
references.pmid: 19093268
references.citation: Infect Immun. 2002 Mar;70(3):1087-96
references.pmid: 11854187
references.citation: Lab Invest. 2008 Aug;88(8):883-95
references.pmid: 18490894