Glycosaminoglycan characterization by electrospray ionization mass spectrometry including fourier transform mass spectrometry.
Electrospray ionization mass spectrometry (ESI MS) is a versatile analytical technique in glycomics of glycosaminoglycans (GAGs). Combined with enzymology, ESI MS is used for assessing changes in disaccharide composition of GAGs biosynthesized under different environmental or physiological conditions. ESI coupled with high-resolution mass analyzers such as a Fourier transform mass spectrometer (FTMS) permits accurate mass measurement of large oligosaccharides and intact GAGs as well as structural characterization of GAG oligosaccharides using information-rich fragmentation methods such as electron detachment dissociation. The first part of this chapter describes methods for disaccharide compositional profiling using ESI MS and the second part is dedicated to FTMS and tandem MS methods of GAG compositional and structural analysis.
Laremore
Tatiana N
TN
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, USA.
Leach
Franklin E
FE
Solakyildirim
Kemal
K
Amster
I Jonathan
IJ
Linhardt
Robert J
RJ
D006025:Glycosaminoglycans / Q000737:chemistry*; D006801:Humans; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
D006025:Glycosaminoglycans
Mass Spectrom Rev. 2009 Mar-Apr;28(2):254-72
18956477
Anal Chem. 2010 Jan 15;82(2):516-22
20000724
Anal Chem. 2007 Mar 1;79(5):2015-22
17253657
Curr Protoc Mol Biol. 2001 May;Chapter 17:Unit17.13B
18265142
Glycoconj J. 2009 Feb;26(2):211-8
18777207
J Am Soc Mass Spectrom. 2008 Feb;19(2):294-304
18055211
Anal Chem. 2003 May 15;75(10):2445-55
12918989
Anal Chem. 2008 Dec 1;80(23):9204-12
19551986
Acta Biochim Pol. 2003;50(3):735-42
14515153
J Am Soc Mass Spectrom. 2008 Jun;19(6):790-8
18499037
Anal Chem. 2009 Jun 1;81(11):4349-55
19402671
Proteomics. 2009 Feb;9(3):686-95
19137549
Electrophoresis. 2004 Jul;25(13):2010-6
15237401
Biochemistry. 1999 Sep 7;38(36):11804-13
10512637
Biochimie. 2003 Jan-Feb;85(1-2):101-7
12765780
Rapid Commun Mass Spectrom. 2002;16(21):2015-24
12391574
Anal Bioanal Chem. 2011 Jan;399(2):737-45
20407891
Anal Bioanal Chem. 2009 Dec;395(8):2489-98
19826794
J Proteome Res. 2008 Apr;7(4):1650-9
18311910
J Am Chem Soc. 2008 Feb 27;130(8):2617-25
18247611
Chem Biol. 2008 Sep 22;15(9):881-92
18804025
Int J Mass Spectrom. 2008 Oct 1;276(2-3):110-115
19802340
Proteomics. 2009 Jul;9(13):3435-44
19557760
Anal Chem. 2003 Jul 1;75(13):3226-31
12964773
Methods Mol Biol. 2010;600:9-30
19882118
J Proteome Res. 2007 Nov;6(11):4374-87
17915907
J Biol Chem. 2009 Sep 18;284(38):25714-22
19596853
Glycobiology. 2003 Nov;13(11):733-42
12799343
J Biol Chem. 1991 Jan 15;266(2):747-51
1898736
Glycoconj J. 2006 Nov;23(7-8):555-63
17006646
J Biol Chem. 2007 Aug 31;282(35):25376-84
17597060
J Am Soc Mass Spectrom. 2007 Feb;18(2):234-44
17074503
Anal Biochem. 2010 Jun 15;401(2):236-41
20211145
Anal Chem. 2005 Sep 15;77(18):5902-11
16159120