[Merkel cell carcinoma revisited: a new example of viro-induced human tumour].
Merkel cell carcinoma (MCC) is a neuroendocrine carcinoma of the skin of poor outcome. A new type of virus, isolated in 2008, was found to be strongly associated with CCM. This virus, belonging to the family of polyomavirus, was called MCPyV for Merkel Carcinoma Polyomavirus. Recent data favour a causative role of MCPyV in oncogenesis. MCC represents thus a new model for the understanding of the mechanisms of oncogenesis. The distinct molecular viral signature in every case of MCC represents an original tool for the follow-up of the disease. New therapeutic perspectives are to be drawn using this model.
Sastre-Garau
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Service de pathologie, département de biologie des tumeurs, institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France. xavier.sastre@curie.net
D015266:Carcinoma, Merkel Cell / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000821:virology*; D002472:Cell Transformation, Viral / Q000235:genetics; D002999:Clone Cells / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D004198:Disease Susceptibility; D005814:Genes, Viral; D006801:Humans; D016867:Immunocompromised Host; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000821:virology; D009856:Oncogene Proteins, Viral / Q000502:physiology; D009857:Oncogenes; D011120:Polyomavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D027601:Polyomavirus Infections / Q000235:genetics / Q000821:virology*; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000235:genetics / Q000821:virology*; D014466:Ultraviolet Rays / Q000009:adverse effects; D016662:Virus Integration
D004273:DNA, Neoplasm; D004279:DNA, Viral; D009856:Oncogene Proteins, Viral