Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
Wadelin
Frances
F
Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, UK.
Fulton
Joel
J
McEwan
Paul A
PA
Spriggs
Keith A
KA
Emsley
Jonas
J
Heery
David M
DM
D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D020224:Expressed Sequence Tags; D006801:Humans; D007938:Leukemia / Q000503:physiopathology*; D008969:Molecular Sequence Data; D005810:Multigene Family; D018365:Neoplasm, Residual; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D015398:Signal Transduction; D013347:Subcellular Fractions / Q000378:metabolism
D000951:Antigens, Neoplasm; C404944:PRAME protein, human; D018168:Receptors, Retinoic Acid
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