title: Arrhythmias in a contemporary fontan cohort: prevalence and clinical associations in a multicenter cross-sectional study.
abstract: OBJECTIVE
  Our aim was to examine the prevalence of arrhythmias and identify independent associations of time to arrhythmia development.
  
  
  BACKGROUND
  Since introduction of the Fontan operation in 1971, long-term results have steadily improved with newer modifications. However, atrial arrhythmias are frequent and contribute to ongoing morbidity and mortality. Data are lacking regarding the prevalence of arrhythmias and risk factors for their development in the current era.
  
  
  METHODS
  The Pediatric Heart Network Fontan Cross-Sectional study evaluated data from 7 centers, with 520 patients age 6 to 18 years (mean 8.6 +/- 3.4 years after the Fontan operation), including echocardiograms, electrocardiograms, exercise testing, parent-reported Child Health Questionnaire (CHQ) results, and medical history.
  
  
  RESULTS
  Supraventricular tachycardias were present in 9.4% of patients. Intra-atrial re-entrant tachycardia (IART) was present in 7.3% (32 of 520). The hazard of IART decreased until 4 to 6 years post-Fontan, and then increased with age thereafter. Cardiac anatomy and resting heart rate (including marked bradycardia) were not associated with IART. We identified 3 independent associations of time to occurrence of IART: lower CHQ physical summary score (p < 0.001); predominant rhythm (p = 0.002; highest risk with paced rhythm), and type of Fontan operation (p = 0.037; highest risk with atriopulmonary connection). Time to IART did not differ between patients with lateral tunnel and extracardiac conduit types of Fontan repair. Ventricular tachycardia was noted in 3.5% of patients.
  
  
  CONCLUSIONS
  Overall prevalence of IART was lower in this cohort (7.3%) than previously reported. Lower functional status, an atriopulmonary connection, and paced rhythm were determined to be independently associated with development of IART after Fontan. (Relationship Between Functional Health Status and Ventricular Performance After Fontan-Pediatric Heart Network; NCT00132782).
authors.affiliation: The Hospital for Sick Children, Toronto, Ontario, Canada. Elizabeth.stephenson@gmail.com
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stephenson
authors.forename: Minmin
authors.initials: M
authors.lastname: Lu
authors.forename: Charles I
authors.initials: CI
authors.lastname: Berul
authors.forename: Susan P
authors.initials: SP
authors.lastname: Etheridge
authors.forename: Salim F
authors.initials: SF
authors.lastname: Idriss
authors.forename: Renee
authors.initials: R
authors.lastname: Margossian
authors.forename: John H
authors.initials: JH
authors.lastname: Reed
authors.forename: Ashwin
authors.initials: A
authors.lastname: Prakash
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Sleeper
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Vetter
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Blaufox
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D018729:Fontan Procedure / Q000009:adverse effects*; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors
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