title: Osseous metaplasia late in the course of nephrogenic systemic fibrosis.
abstract: Osseous metaplasia has recently been described in several cases of nephrogenic systemic fibrosis, sometimes in association with unusual clinical features such as painful hyperkeratotic spicules, palpable bony masses, and disease regression. Some authors have suggested that it may mainly occur late in the disease course or even be a marker for involuting nephrogenic systemic fibrosis. Here, we present a 27-year-old woman with a 7-year history of nephrogenic systemic fibrosis, who developed cutaneous osseous metaplasia.
authors.affiliation: Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA. dberk@dom.wustl.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Berk
authors.forename: Alicia
authors.initials: A
authors.lastname: Miller
authors.forename: Debra
authors.initials: D
authors.lastname: Scarlett
authors.forename: Franz J
authors.initials: FJ
authors.lastname: Wippold
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Bayliss
authors.forename: Dongsi
authors.initials: D
authors.lastname: Lu
mesh_terms: D000328:Adult; D000700:Analgesics / Q000009:adverse effects; D002114:Calcinosis / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000473:pathology*; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000473:pathology; D008679:Metaplasia / Q000473:pathology; D054989:Nephrogenic Fibrosing Dermopathy / Q000188:drug therapy / Q000473:pathology*; D000069583:Pregabalin; D011796:Quinacrine / Q000627:therapeutic use; D012867:Skin / Q000473:pathology*; D013792:Thalidomide / Q000627:therapeutic use; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives
chemical_list: D000700:Analgesics; D006886:Hydroxychloroquine; D013792:Thalidomide; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D011796:Quinacrine