Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): a comparative study with TMPyP4.
The cationic porphyrin TPrPyP4, with four propyl substituents in the pyridinium rings, is evaluated in vitro by spectroscopic and polymerase-stop assays as a G4-DNA ligand and in cultured cells as a modulator of gene transcription. A comparison with the widely used TMPyP4 is presented.
Cogoi
Susanna
S
Department of Biomedical Science and Technology, University of Udine, 33100 Udine, Italy.
Xodo
Luigi E
LE
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D020128:Inhibitory Concentration 50; D051379:Mice; D011166:Porphyrins / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D011166:Porphyrins; D004247:DNA