title: Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol.
abstract: Two efficient routes are reported for the synthesis of both enantiomers of trifluoroalaninol in enantiopure form. The first pathway involves a Strecker-type reaction performed from a chiral trifluoromethyloxazolidine (Fox). The second route, which is more direct, involves, as a key step, the reduction of chiral oxazolidines or imines derived from ethyl trifluoropyruvate.
authors.affiliation: Université de Cergy-Pontoise, Laboratoire SOSCO, F-95000, Cergy-Pontoise, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Pytkowicz
authors.forename: Olivier
authors.initials: O
authors.lastname: Stéphany
authors.forename: Sinisa
authors.initials: S
authors.lastname: Marinkovic
authors.forename: Sébastien
authors.initials: S
authors.lastname: Inagaki
authors.forename: Thierry
authors.initials: T
authors.lastname: Brigaud
mesh_terms: D010080:Oxazoles / Q000737:chemistry*; D011412:Propanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D019289:Pyruvic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010080:Oxazoles; D011412:Propanolamines; C513102:ethyl trifluoropyruvate; C064210:oxazolidine; C034448:2-aminopropanol; D019289:Pyruvic Acid