A new isoflavone glycoside from the stem bark of Sophora japonica.
A new isoflavone glycoside, 6-methoxy-7-hydroxy-4'-O-beta-D-glucosyl isoflavone, glycitein-4'-O-beta-D-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory effects of all the isolated compounds on aldose reductase were evaluated in vitro. Among these compounds, daidzein (1), puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC(50) values of 3.2, 6.4, and 1.9 microM, respectively.
Park
Hyun Young
HY
College of Pharmacy, Kangwon National University, Chuncheon, 200-701, Korea.
Kim
Soo Hee
SH
Kim
Gi Beom
GB
Sim
Jae Young
JY
Lim
Soon Sung
SS
Kim
Myong Jo
MJ
Chun
Wanjoo
W
Kwon
Yong Soo
YS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000201:enzymology; D024301:Plant Bark; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora / Q000737:chemistry*; D013057:Spectrum Analysis
D004791:Enzyme Inhibitors; D005419:Flavonoids; D006027:Glycosides; D007529:Isoflavones; D000449:Aldehyde Reductase