title: Effects of supervised aerobic exercise training on serum adiponectin and parameters of lipid and glucose metabolism in subjects with moderate dyslipidemia.
abstract: OBJECTIVE
  To examine the effects of supervised aerobic exercise training on serum adiponectin and lipids, including triglyceride (TG)-rich lipoproteins, in moderate dyslipidemic subjects.
  
  
  METHODS
  Twenty-five dyslipidemic patients [mean body mass index (BMI)=24.6 kg/m²; mean age= 39 years; mean total cholesterol=226 mg/dL; mean TG=149 mg/dL] without metabolic syndrome, diabetes, and hypertension underwent supervised aerobic exercise training (60 min/day, 2 to 3 times/week) at an intensity of 60-80% of age-predicted maximal heart rate for 16 weeks. Lipoprotein cholesterol levels were measured by our established anion-exchange HPLC method.
  
  
  RESULTS
  Aerobic exercise training significantly decreased BMI, cholesterol levels of LDL- and IDL-, and markedly reduced VLDL-cholesterol at week 8 (-45%) and week 16 (-50%), but changes in TG and HDL-cholesterol were not significant. Adiponectin significantly increased by 51% and HOMA-R was significantly decreased at week 16, although changes in these parameters were not significant at week 8. There was no significant relationship between changes in adiponectin and in VLDL- or IDL- cholesterol, but changes in adiponectin were inversely but insignificantly associated with changes in BMI (r=-0.343, p=0.095).
  
  
  CONCLUSIONS
  These results suggest that supervised aerobic exercise training two to three times/week in the presence of body weight loss increases serum adiponectin with an improved lipid profile and insulin sensitivity at week 16 in non-obese moderate dyslipidemic patients, and that VLDL-cholesterol is markedly decreased by supervised aerobic exercise training.
authors.affiliation: Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan. hyoshida@jikei.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Michiko
authors.initials: M
authors.lastname: Suto
authors.forename: Hideo
authors.initials: H
authors.lastname: Kurosawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirowatari
authors.forename: Kumie
authors.initials: K
authors.lastname: Ito
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Yanai
authors.forename: Norio
authors.initials: N
authors.lastname: Tada
authors.forename: Masato
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D050171:Dyslipidemias / Q000378:metabolism* / Q000473:pathology; D015444:Exercise; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011379:Prognosis; D014280:Triglycerides / Q000097:blood*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008074:Lipoproteins; D014280:Triglycerides; C030087:lipoprotein triglyceride