Indoloditerpenes from an algicolous isolate of Aspergillus oryzae.
Two new indoloditerpene derivatives asporyzin A (1) and asporyzin B (2), one new indoloditerpene asporyzin C (3), and three known related indoloditerpenes JBIR-03 (4), emindole SB (5), and emeniveol (6) were isolated from an endophytic fungus Aspergillus oryzae, isolated from the marine red alga Heterosiphonia japonica. Their structures were unambiguously established by spectroscopic techniques. In addition, all the isolates were evaluated preliminarily for insecticidal and antimicrobial activities in order to probe into their chemical defensive function. Compound 4 was more active against brine shrimp than the others, and 3 possessed potent activity against Escherichia coli.
Qiao
Ming-Feng
MF
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Ji
Nai-Yun
NY
Liu
Xiang-Hong
XH
Li
Ke
K
Zhu
Qing-Mei
QM
Xue
Qin-Zhao
QZ
D000110:Acetylcholinesterase / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001236:Aspergillus oryzae / Q000737:chemistry*; D001921:Brain / Q000201:enzymology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification; D008968:Molecular Conformation; D000461:Rhodophyta / Q000382:microbiology
D000890:Anti-Infective Agents; D004224:Diterpenes; D007211:Indoles; D007306:Insecticides; C526003:JBIR-03; C555991:asporyzin A; C555992:asporyzin B; C555993:asporyzin C; D000110:Acetylcholinesterase