title: Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor.
abstract: Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.
authors.affiliation: Department of Physiology, Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, South Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Jang
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Shin
authors.forename: Junyang
authors.initials: J
authors.lastname: Jung
authors.forename: Sang Hwa
authors.initials: SH
authors.lastname: Lee
authors.forename: Su-Yeong
authors.initials: SY
authors.lastname: Seo
authors.forename: Duk Joon
authors.initials: DJ
authors.lastname: Suh
authors.forename: Hwan Tae
authors.initials: HT
authors.lastname: Park
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D002478:Cells, Cultured; D020934:Ciliary Neurotrophic Factor / Q000494:pharmacology / Q000502:physiology*; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism*; D020869:Gene Expression Profiling; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D021381:Protein Transport; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000378:metabolism*
chemical_list: D020934:Ciliary Neurotrophic Factor; C449760:Dpysl3 protein, rat; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger