Macrocycles as a tool: a facile and one-pot synthesis of silver nanoparticles using cucurbituril designed for cancer therapeutics.
Silver nanoparticles made easy: A simple, effective, and one-pot method toward the synthesis of a defined macrocycle-silver nanoparticle system in water has been described (see figure). Interestingly, cucurbituril (CB)[7]-protected AgNPs showed significantly increased cytotoxicity against MCF-7 and NCI-H358 cancer cells, as demonstrated by models in vitro.
Premkumar
Thathan
T
Department of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, South Korea.
Lee
Yeonju
Y
Geckeler
Kurt E
KE
D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000627:therapeutic use; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D012834:Silver / Q000737:chemistry*; D012972:Sodium Hydroxide / Q000737:chemistry; D014867:Water / Q000737:chemistry; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D007093:Imidazoles; D012834:Silver; D012972:Sodium Hydroxide; D014867:Water; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils