title: Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients.
abstract: BACKGROUND
  Patients with late onset hypogonadism (LOH) also suffered from lower urinary tract symptoms (LUTS) and LOH symptoms. The objects of this study are to evaluate the efficacy of testosterone replace therapy (TRT) by testosterone ointment (Glowmin: GL) for LUTS in LOH patients.
  
  
  METHODS
  The Aging Male Symptom (AMS) scale, Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36), International Index of Erectile Function (IIEF-5) and the International Prostate Symptom Score (IPSS) were obtained from patients with LOH. A total of 41 patients with LOH have been treated with TRT using 6 mg/day of GL for 3 months. Serum free testosterone levels (FT) and these four scores were compared before and after TRT.
  
  
  RESULTS
  Serum FT levels and the scores for the four parameters of AMS, six of eight domains in SF-36, IIEF-5 and total IPSS improved significantly after 3 months TRT. In addition, all IPSS domains also improved significantly, and voiding disturbance seems to have improved more than storage disturbance (P = 0.0280 vs. 0.0483).
  
  
  CONCLUSIONS
  TRT by administration of GL is considered to be effective in the improvement of not only ED and LOH symptoms, but also LUTS (especially voiding disturbance) of patients with LOH.
authors.affiliation: Department of Urology, Nagano Red Cross Hospital, Nagano, Japan. amanot@nagano-med.jrc.or.jp
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Amano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Imao
authors.forename: Katsurou
authors.initials: K
authors.lastname: Takemae
authors.forename: Teruaki
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakanome
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D054796:Drug Dosage Calculations; D005837:Genitalia, Male / Q000187:drug effects* / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage; D010410:Penile Erection / Q000187:drug effects*; D010865:Pilot Projects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D018434:Sickness Impact Profile; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood; D016896:Treatment Outcome
chemical_list: D009824:Ointments; D013739:Testosterone