title: Ciliary blood flow and aqueous humor production.
abstract: Aqueous humor production is a metabolically active process sustained by the delivery of oxygen and nutrients and removal of metabolic waste by the ciliary circulation. This article describes our investigations into the relationship between ciliary blood flow and aqueous humor production. The results presented indicate that there is a dynamic relationship between ciliary blood flow and aqueous humor production, with production being blood flow independent above a critical level of perfusion, and blood flow dependent below it. The results also show that the plateau portion of the relationship shifts up or down depending on the level of secretory stimulation or inhibition, and that oxygen is one critical factor provided by ciliary blood flow. Also presented is a theoretical model of ocular hydrodynamics incorporating these new findings.
authors.affiliation: Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. kiel@uthscsa.edu
authors.forename: J W
authors.initials: JW
authors.lastname: Kiel
authors.forename: M
authors.initials: M
authors.lastname: Hollingsworth
authors.forename: R
authors.initials: R
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: H A
authors.initials: HA
authors.lastname: Reitsamer
mesh_terms: D000704:Analysis of Variance; D001082:Aqueous Humor / Q000378:metabolism*; D002924:Ciliary Body / Q000033:anatomy & histology / Q000098:blood supply*; D003198:Computer Simulation; D004728:Endothelium, Corneal / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D057446:Hydrodynamics; D007429:Intraocular Pressure / Q000502:physiology; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D010100:Oxygen
references.citation: Exp Eye Res. 1999 Oct;69(4):413-29
references.pmid: 10504275
references.citation: Am J Physiol. 1981 Aug;241(2):G143-9
references.pmid: 7270691
references.citation: Trends Pharmacol Sci. 2004 Mar;25(3):152-7
references.pmid: 15019271
references.citation: Arch Ophthalmol. 1960 Apr;63:707-14
references.pmid: 14444370
references.citation: J Ocul Pharmacol Ther. 2007 Feb;23(1):21-6
references.pmid: 17341146
references.citation: Invest Ophthalmol Vis Sci. 1980 May;19(5):518-21
references.pmid: 6768691
references.citation: Exp Eye Res. 1990 Dec;51(6):651-61
references.pmid: 2265676
references.citation: Acta Physiol Scand. 1968 Aug;73(4):511-22
references.pmid: 4179191
references.citation: Exp Eye Res. 2006 Mar;82(3):405-15
references.pmid: 16198336
references.citation: Invest Ophthalmol Vis Sci. 2009 May;50(5):2301-7
references.pmid: 19182250
references.citation: Ophthalmologica. 1963;146:137-42
references.pmid: 14061447
references.citation: Acta Physiol Scand. 1968 May-Jun;73(1):204-19
references.pmid: 4175033
references.citation: J Physiol. 1914 Sep 8;48(5):357-79
references.pmid: 16993262
references.citation: Exp Eye Res. 2001 Sep;73(3):355-64
references.pmid: 11520110
references.citation: Br J Pharmacol. 2006 Jan;147 Suppl 1:S172-81
references.pmid: 16402102
references.citation: Exp Eye Res. 1992 May;54(5):731-6
references.pmid: 1623958
references.citation: Invest Ophthalmol Vis Sci. 1991 Dec;32(13):3145-66
references.pmid: 1748546
references.citation: Am J Ophthalmol. 1976 Jul;82(1):59-63
references.pmid: 779486
references.citation: Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3728-34
references.pmid: 12454044
references.citation: Invest Ophthalmol Vis Sci. 1996 May;37(6):966-75
references.pmid: 8631640
references.citation: Gastroenterology. 1983 Sep;85(3):529-34
references.pmid: 6873601
references.citation: Acta Physiol Scand. 1952 Jul 17;26(1):57-69
references.pmid: 12985397
references.citation: Invest Ophthalmol Vis Sci. 1992 Jul;33(8):2399-410
references.pmid: 1634337
references.citation: Invest Ophthalmol Vis Sci. 1988 Apr;29(4):621-5
references.pmid: 2895754
references.citation: Pharmacol Rev. 1998 Sep;50(3):413-92
references.pmid: 9755289
references.citation: Invest Ophthalmol Vis Sci. 1980 Apr;19(4):423-8
references.pmid: 6153641
references.citation: J Appl Physiol (1985). 1987 Dec;63(6):2554-7
references.pmid: 3436887
references.citation: Am J Ophthalmol. 1981 Sep;92(3):407-15
references.pmid: 7294101
references.citation: Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1837-40
references.pmid: 11431451
references.citation: Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1325-40
references.pmid: 3610551
references.citation: Invest Ophthalmol Vis Sci. 2003 Sep;44(9):3967-71
references.pmid: 12939316
references.citation: Acta Physiol Scand. 1951 Apr 25;22(2-3):83-6
references.pmid: 14933129
references.citation: Invest Ophthalmol Vis Sci. 1977 Oct;16(10):912-24
references.pmid: 409693
references.citation: Invest Ophthalmol Vis Sci. 1985 Dec;26(12):1781-4
references.pmid: 4066215
references.citation: Invest Ophthalmol Vis Sci. 1979 Feb;18(2):133-44
references.pmid: 104933
references.citation: Invest Ophthalmol Vis Sci. 1996 May;37(6):958-65
references.pmid: 8631639
references.citation: Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1571-80
references.pmid: 16565394
references.citation: Circ Res. 1980 Dec;47(6):807-13
references.pmid: 6254686
references.citation: Exp Eye Res. 1966 Jul;5(3):208-20
references.pmid: 5914653
references.citation: Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2697-703
references.pmid: 12147605
references.citation: Am J Physiol. 1982 Jun;242(6):G565-9
references.pmid: 7091329
references.citation: Br J Pharmacol. 2001 Sep;134(2):241-5
references.pmid: 11564641
references.citation: Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1614-20
references.pmid: 19875657
references.citation: Dig Dis Sci. 1982 Aug;27(8):675-9
references.pmid: 7094790
references.citation: Nature. 1972 Jul 21;238(5360):158-9
references.pmid: 4558458
references.citation: Exp Eye Res. 1969 Jul;8(3):284-91
references.pmid: 4979354
references.citation: Invest Ophthalmol Vis Sci. 1994 Jul;35(8):3325-31
references.pmid: 8045722
references.citation: Invest Ophthalmol. 1963 Dec;2:584-90
references.pmid: 14106749
references.citation: Invest Ophthalmol Vis Sci. 1995 Mar;36(3):579-85
references.pmid: 7890489
references.citation: Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2485-9
references.pmid: 9804159
references.citation: Exp Eye Res. 1973 Jan 1;15(1):15-29
references.pmid: 4630581
references.citation: Curr Eye Res. 1984 Dec;3(12):1391-5
references.pmid: 6525879
references.citation: Invest Ophthalmol Vis Sci. 1980 Jan;19(1):43-8
references.pmid: 7350133