title: Pyogenic ventriculitis complicating Aggregatibacter aphrophilus infective endocarditis: A case report and literature review.
abstract: Pyogenic ventriculitis (PV) is an uncommon, but frequently fatal infection that results from inflammation of the ventricular ependymal lining associated with a purulent ventricular system. PV has been rarely reported as a secondary complication of infective endocarditis. Prompt diagnosis and treatment with appropriate culture-directed antibiotics with adequate central nervous system penetration is crucial when managing patients who are suspected of having PV. The present study reports on a fatal case of a previously well 42-year-old alcoholic woman with infective endocarditis caused by Aggregatibacter aphrophilus, with secondary brain abscess and spontaneous rupture into the ventricles causing PV.
authors.affiliation: Faculty of Medicine and Dentistry;
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Jung
authors.forename: Michael D
authors.initials: MD
authors.lastname: Parkins
authors.forename: Deirdre
authors.initials: D
authors.lastname: Church
references.citation: AJNR Am J Neuroradiol. 2001 Sep;22(8):1510-6
references.pmid: 11559498
references.citation: Infection. 1998 Nov-Dec;26(6):405-7
references.pmid: 9861570
references.citation: Microbes Infect. 2000 Jul;2(8):897-906
references.pmid: 10962273
references.citation: APMIS. 2003 Jun;111(6):653-7
references.pmid: 12969021
references.citation: Acta Neurochir (Wien). 1998;140(12):1263-70
references.pmid: 9932127
references.citation: Eur J Clin Microbiol Infect Dis. 2004 Jan;23(1):7-14
references.pmid: 14669073
references.citation: Annu Rev Med. 1997;48:25-33
references.pmid: 9046942
references.citation: Clin Infect Dis. 1997 Jun;24(6):1087-94
references.pmid: 9195062
references.citation: Am J Emerg Med. 2007 Jan;25(1):120-2
references.pmid: 17157709
references.citation: Int J Infect Dis. 2006 Mar;10(2):103-9
references.pmid: 16310393
references.citation: Pediatr Infect Dis J. 2008 Jan;27(1):84-5
references.pmid: 18162951
references.citation: J Microbiol Immunol Infect. 2002 Sep;35(3):184-6
references.pmid: 12380792
references.citation: Clin Infect Dis. 2001 Dec 15;33(12):2028-33
references.pmid: 11712094
references.citation: Int J Syst Evol Microbiol. 2006 Sep;56(Pt 9):2135-2146
references.pmid: 16957111
references.citation: Surg Neurol. 2005 May;63(5):442-9; discussion 449-50
references.pmid: 15883068
references.citation: J Clin Microbiol. 2006 Jan;44(1):257-9
references.pmid: 16390985