Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines.
The clinical significance of pyran and pyrimidine condensed systems and the raise in problem of multidrug resistant bacterial pathogens has directed us to synthesize pyranopyrimidine derivatives via the reactions of the versatile, 2-amino-4-(4-methoxyphenyl)-4H-substituted chromene-3-carbonitrile with the appropriate reagents. The newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR, Mass spectra and Elemental analysis. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv [ATCC-27294] and antibacterial activity against Staphylococcus aureus [ATCC-25923] and Streptococcus pyogenes [MTCC-443] as gram-positive, Escherichia coli [ATCC-25922] and Pseudomonas aeruginosa [MTCC-441] as gram-negative bacterial strains and antifungal activity against Aspergillus niger [MTCC-282]. Several derivatives exhibited pronounced antitubercular and antimicrobial activities.
Kamdar
Nimesh R
NR
Department of Chemistry, Veer Narmad South Gujarat University, Surat-395007, Gujarat, India. nimesh_r_kamdar@yahoo.co.in
Haveliwala
Dhaval D
DD
Mistry
Prashant T
PT
Patel
Saurabh K
SK
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D011743:Pyrimidines