title: Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins.
abstract: Multiplexed SERS imaging of receptor proteins on the surface of mammalian cells has been carried out using functionalized silver nanoparticles. Deconvolution of four differently functionalized nanoparticles is readily achieved, and using this approach, receptor co-localization can be probed and protein-protein interactions can be elucidated at the surface of cells.
authors.affiliation: Steacie Institute for Molecular Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, K1A 0R6, Canada.
authors.forename: David C
authors.initials: DC
authors.lastname: Kennedy
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Hoop
authors.forename: Li-Lin
authors.initials: LL
authors.lastname: Tay
authors.forename: John Paul
authors.initials: JP
authors.lastname: Pezacki
mesh_terms: D000818:Animals; D051244:Caveolin 3 / Q000737:chemistry; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018613:Microscopy, Confocal; D032383:Myocytes, Cardiac / Q000166:cytology; D051381:Rats; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman
chemical_list: D051244:Caveolin 3; D008024:Ligands; D008565:Membrane Proteins; D018343:Receptors, Adrenergic, beta-2; D012834:Silver