[Molecular aspects of antineoplasic action of vitamin D].
The effects of the environment, particularly dietary factors, may influence in the development and prevention of cancer. Vitamin D (colecalciferol) has been associated for years with calcium homeostasis regulation, but many epidemiological, biochemical and genetic studies reveal non classic effects of vitamin D, such as vitamin D involvement in the progression of different types of cancer. The aim of the present article was to give a review about the molecular mechanisms of the antineoplasic action of vitamin D. These effects are still not completely established, but it is well known that vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis and alters cellular adhesion. To maintain suitable vitamin D levels seems to be necessary for many physiological processes, and not only for bone homeostasis. Clinical studies might determine vitamin D levels that can also protect against the cancer development.
Bohl
Luciana Paola
LP
Laboratorio de Metabolismo Fosfocálcico Dr. F Calas, Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas, UNC. 20 Piso, Pabellón Argentina, CiudaI Universitaria, Córdoba, Argentina.
Liaudat
Ana Cecilia
AC
Picotto
Gabriela
G
Tolosa de Talamoni
Nori Graciela
NG
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002117:Calcitriol / Q000502:physiology / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D014807:Vitamin D / Q000502:physiology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014807:Vitamin D; D002117:Calcitriol