Post-licensure comparison of the safety profile of diphtheria/tetanus/whole cell pertussis/haemophilus influenza type b vaccine and a 5-in-1 diphtheria/tetanus/acellular pertussis/haemophilus influenza type b/polio vaccine in the United Kingdom.
General practitioner consultation data were used to compare the reactogenicity in infants of a 5-in-1 acellular pertussis vaccine (DTaP(5)/Hib/IPV) introduced in the United Kingdom in 2004 to the 4-in-1 whole cell-pertussis vaccine (DTwP/Hib) that it replaced. For each vaccine the incidence in the week following vaccination was compared to other periods to obtain a relative incidence. A lower relative incidence of crying, fever and local reactions was seen with DTaP(5)/Hib/IPV than DTwP/Hib. Although there were no other significant differences between vaccines the relative incidence was significantly above one on the day of vaccination for convulsions following DTwP/Hib and for apnoea/collapse following DTaP(5)/Hib/IPV.
Andrews
Nick
N
Statistics Unit, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom. nick.andrews@hpa.org.uk
Stowe
Julia
J
Wise
Lesley
L
Miller
Elizabeth
E
D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D058005:General Practitioners; D018073:Haemophilus Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D011358:Product Surveillance, Postmarketing; D006113:United Kingdom; D018074:Vaccines, Conjugate / Q000009:adverse effects
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D011054:Poliovirus Vaccine, Inactivated; D018074:Vaccines, Conjugate; C541234:diphtheria-tetanus-five component acellular pertussis-inactivated poliomyelitis -Haemophilus influenzae type b conjugate vaccine