title: Selective proteolysis sets the tempo of the cell cycle.
abstract: Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control in all eukaryotes. This is achieved by the action of ubiquitin ligases (E3s), which remove both negative and positive regulators of the cell cycle. Though our current understanding of the plant cell cycle has improved a lot these recent years, the identity of the E3s regulating it and their mode of action is still in its infancy. Nevertheless, recent research in Arabidopsis revealed some novel findings in this area. Thus the anaphase promoting complex/cyclosome (APC/C) not only controls mitotic events, but is also important in post-mitotic cells for normal plant development and cell differentiation. Moreover conserved and novel E3s were identified that target cyclin-dependent kinase inhibitors at different plant developmental stages. Finally, environmental constrains and stress hormones negatively impact on the cell cycle by processes that also include E3s.
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Conventionné avec l'Université de Strasbourg, 67084 Strasbourg, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Marrocco
authors.forename: Marc
authors.initials: M
authors.lastname: Bergdoll
authors.forename: Patrick
authors.initials: P
authors.lastname: Achard
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Criqui
authors.forename: Pascal
authors.initials: P
authors.lastname: Genschik
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D059828:Plant Cells; D010937:Plant Growth Regulators / Q000378:metabolism; D010944:Plants / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism
chemical_list: D010937:Plant Growth Regulators; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases