title: Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion.
abstract: Simple oil-in-water emulsion led to structural complexity at both the surface and interior of the PLGA microsphere. A golf ball-like dimpled surface comes from the heteroaggregation of volatile nonsolvent colloid originating from the inside of the organic droplet as supported by in situ optical microscopy. The internal porous structure and encapsulation of hydrophobic agent inside the microparticle implies its potential application as a drug carrier.
authors.affiliation: Division of Advanced Materials Engineering and Institute for Rare Metals, Kongju National University, Cheonan, Chungnam, 331-717, Korea.
authors.forename: Mi Ri
authors.initials: MR
authors.lastname: Kim
authors.forename: Seungwoo
authors.initials: S
authors.lastname: Lee
authors.forename: Jung-Ki
authors.initials: JK
authors.lastname: Park
authors.forename: Kuk Young
authors.initials: KY
authors.lastname: Cho
mesh_terms: D004655:Emulsions; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004655:Emulsions; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid