title: Nicolau syndrome: an iatrogenic cutaneous necrosis.
abstract: Nicolau syndrome is an uncommon complication of intramuscular injection leading to variable degrees of necrosis of skin and the underlying tissues. We report here two cases of this syndrome. Our first case was a 25 year-old male who developed intense pain and purplish discoloration of the skin in the right hip after intramuscular diclofenac injection. The second case was a 60 year-old male who developed intense pain and discoloration of skin, not only at the injection site, but also on the left scapular area and left elbow after receiving chlorpheniramine maleate injection intramuscularly. These cases highlight the need for awareness about this condition and the need to exercise utmost care during the administration of any parenteral injections by dermatologists.
authors.affiliation: Department of Dermatology, Adichunchanagiri Institute of Medical Sciences, BG Nagar, Karnataka, India.
authors.forename: Kc
authors.initials: K
authors.lastname: Nischal
authors.forename: Hb
authors.initials: H
authors.lastname: Basavaraj
authors.forename: Mr
authors.initials: M
authors.lastname: Swaroop
authors.forename: Dp
authors.initials: D
authors.lastname: Agrawal
authors.forename: Bd
authors.initials: B
authors.lastname: Sathyanarayana
authors.forename: Np
authors.initials: N
authors.lastname: Umashankar
references.citation: Clin Exp Dermatol. 2008 Aug;33(5):555-8
references.pmid: 18627396
references.citation: Int J Dermatol. 2006 Nov;45(11):1326-8
references.pmid: 17076716
references.citation: Eur J Dermatol. 1999 Mar;9(2):132-3
references.pmid: 10066964
references.citation: J Orthop Surg (Hong Kong). 2006 Apr;14(1):104-7
references.pmid: 16598099
references.citation: Acta Orthop Belg. 2008 Dec;74(6):860-4
references.pmid: 19205337
references.citation: J Postgrad Med. 2008 Oct-Dec;54(4):332-4
references.pmid: 18953160
references.citation: Hautarzt. 2005 Oct;56(10):968-9
references.pmid: 16142495
references.citation: J Burn Care Res. 2006 Jul-Aug;27(4):541-4
references.pmid: 16819362
references.citation: Eur J Pediatr. 2009 Dec;168(12):1541-2
references.pmid: 19277707
references.citation: J Dtsch Dermatol Ges. 2007 Dec;5(12):1122-3
references.pmid: 18042092
references.citation: Joint Bone Spine. 2003 Sep;70(5):390-2
references.pmid: 14563471
references.citation: J Eur Acad Dermatol Venereol. 2001 Nov;15(6):585-8
references.pmid: 11843224
references.citation: Int J Dermatol. 2005 Dec;44(12):1069-70
references.pmid: 16409285
references.citation: Plast Reconstr Surg. 2003 Dec;112(7):1970-1
references.pmid: 14663268
references.citation: J Dermatol. 2008 Jan;35(1):18-20
references.pmid: 18181770
references.citation: Praxis (Bern 1994). 2006 Sep 27;95(39):1499-503
references.pmid: 17061464
references.citation: Z Hautkr. 1985 Oct 15;60(20):1639-45
references.pmid: 2932865
references.citation: J Drugs Dermatol. 2006 Apr;5(4):377-8
references.pmid: 16673810
references.citation: Acta Derm Venereol. 2005;85(4):372-3
references.pmid: 16191871