Dihydro-resveratrol--a potent dietary polyphenol.
Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562).
Gakh
Andrei A
AA
Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA. gakhaa@ornl.gov
Anisimova
Natalia Yu
NY
Kiselevsky
Mikhail V
MV
Sadovnikov
Sergey V
SV
Stankov
Ivan N
IN
Yudin
Mikhail V
MV
Rufanov
Konstantin A
KA
Krasavin
Mikhail Yu
MY
Sosnov
Andrey V
AV
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D019587:Dietary Supplements; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*; D014920:Wine
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol