title: Novel 'nano in nano' composites for sustained drug delivery: biodegradable nanoparticles encapsulated into nanofiber non-wovens.
abstract: Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.
authors.affiliation: Department of Pharmaceutics and Biopharmacy, Philipps-Universität Marburg, 35037 Marburg, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Beck-Broichsitter
authors.forename: Marcel
authors.initials: M
authors.lastname: Thieme
authors.forename: Juliane
authors.initials: J
authors.lastname: Nguyen
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmehl
authors.forename: Tobias
authors.initials: T
authors.lastname: Gessler
authors.forename: Werner
authors.initials: W
authors.lastname: Seeger
authors.forename: Seema
authors.initials: S
authors.lastname: Agarwal
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiner
authors.forename: Thomas
authors.initials: T
authors.lastname: Kissel
mesh_terms: D004396:Coloring Agents / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004553:Electric Conductivity; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011098:Polyglactin 910 / Q000737:chemistry*; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013500:Surface Tension; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D004396:Coloring Agents; D003374:Coumarins; D013844:Thiazoles; C517282:coumarin 6; D011098:Polyglactin 910