title: Serum biological antioxidant potential predicts the prognosis of hemodialysis patients.
abstract: BACKGROUND
  It is well known that oxidative stress is enhanced in patients with end-stage renal disease. However, little is known about the relationship between serum antioxidant capacity and clinical outcome in hemodialysis (HD) patients.
  
  
  METHODS
  We examined the relationship between serum biomarkers of oxidative stress and clinical outcomes including all-cause mortality, hospitalization rate and incidence of cardiovascular events in HD patients. As biomarkers of oxidative stress, we measured serum levels of coenzyme Q10 (CoQ10) and biological antioxidant potential (BAP).
  
  
  RESULTS
  108 patients were observed for 30 months as the follow-up periods. The survival group (n = 83) showed significantly higher BAP values compared with those in death groups (n = 25; p < 0.05). When serum BAP levels were divided into two groups by their median value, the group with higher BAP values had a better survival rate than that with lower BAP values on the Kaplan-Meier survival analysis (p = 0.05). Although serum levels of CoQ10 did not show any association with clinical outcomes, lower BAP was selected as an independent risk factor for all-cause mortality as well as the absence of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers therapy by age-adjusted Cox regression analysis.
  
  
  CONCLUSIONS
  This study indicated that BAP could predict the prognosis of HD patients.
authors.affiliation: Department of Nephrology, Immunology, and Vascular Medicine, Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishii
authors.forename: Takayasu
authors.initials: T
authors.lastname: Ohtake
authors.forename: Koji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mochida
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ishioka
authors.forename: Machiko
authors.initials: M
authors.lastname: Oka
authors.forename: Kyoko
authors.initials: K
authors.lastname: Maesato
authors.forename: Ryota
authors.initials: R
authors.lastname: Ikee
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Moriya
authors.forename: Sumi
authors.initials: S
authors.lastname: Hidaka
authors.forename: Kent
authors.initials: K
authors.lastname: Doi
authors.forename: Eisei
authors.initials: E
authors.lastname: Noiri
authors.forename: Toshiro
authors.initials: T
authors.lastname: Fujita
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality; D015996:Survival Rate / Q000639:trends
chemical_list: D000975:Antioxidants; D015415:Biomarkers