title: Occurrence of synthetic musk fragrances in human blood from 11 cities in China.
abstract: We measured two nitro musk fragrances (musk xylene) and musk ketone) and five polycyclic musk fragrances (galaxolide [HHCB], tonalide [AHTN], celestolide [ADBI], traseolide [ATII], and phantolide [AHMI]) in human blood samples from 11 cities of China (n = 204). Possible temporal trends in musk concentrations and associations with personal factors, such as gender, age, and others, were studied. Galaxolide (HHCB) showed the highest median concentration (0.85 ng/g) followed by AHTN (0.53 ng/g) with high detection frequency (91 and 77%, respectively). Concentrations of the other synthetic musk fragrances, including musk ketone and musk xylene, were all below the quantification limits. The results suggested that musk concentrations were not significantly relative to gender and body weight but positively correlated with age groups and locations. Apparent differences were also observed in the ratios of HHCB to AHTN concentrations among different cities.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing, 100085, People's Republic of China.
authors.forename: Zhengjun
authors.initials: Z
authors.lastname: Hu
authors.forename: Yali
authors.initials: Y
authors.lastname: Shi
authors.forename: Hongyun
authors.initials: H
authors.lastname: Niu
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Cai
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001578:Benzopyrans / Q000097:blood; D002681:China; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D005260:Female; D006801:Humans; D007189:Indans / Q000097:blood; D008297:Male; D008875:Middle Aged; D013764:Tetrahydronaphthalenes / Q000097:blood; D055815:Young Adult
chemical_list: C110695:5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane; D001578:Benzopyrans; D005229:Fatty Acids, Monounsaturated; D007189:Indans; D013764:Tetrahydronaphthalenes; C008563:musk; C033118:acetyl tert-butyl dimethylindan; C033119:galaxolide; C033117:phantolid; C033116:acetyl methyl tetramethyl tetralin