Potential pathomechanisms of ADHD based on neurometabolite changes.
Attention deficit hyperactivity disorder (ADHD) is a most common psychiatric disorder in the childhood. The exact pathomechanisms related to ADHD core symptoms--hyperactivity, impulsivity and inattention--are still unclear. The developmental dysfunction of cortical-striatal-thalamic-cortical network combined with the dysregulation of catecholamine neurotransmitters could be responsible for symptoms of the disorder. Magnetic resonance spectroscopy is a method which allows a partial view on molecular mechanisms of biochemical and metabolic processes in human brain by in vivo measurement. We address the hypothesis of a potential pathomechanisms associated with ADHD symptoms which is based on the studies concerning magnetic resonance spectroscopy method and ADHD.
Husarova
Veronika
V
Clinic of Psychiatry, Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. nika.husarova@gmail.com
Ondrejka
Igor
I
Tonhajzerova
Ingrid
I
D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009415:Nerve Net / Q000378:metabolism / Q000503:physiopathology
D002395:Catecholamines