title: Retinitis pigmentosa associated with asteroid hyalosis.
abstract: BACKGROUND
  Asteroid hyalosis (AH) is a condition in which cream-colored or white spherical particles are suspended in the vitreous body. Asteroid hyalosis is considered not to cause decreased vision or any other visual symptoms except in rare cases. There have been a few reports of AH in patients with retinitis pigmentosa (RP).
  
  
  METHODS
  To assess the prevalence of AH in patients with RP, 320 patients with typical forms of RP were studied. One patient was offered a standard three-port vitrectomy, and the spherical particles obtained from her vitrectomy sample were analyzed using an energy-dispersive x-ray spectrometer.
  
  
  RESULTS
  Ten patients (two men and eight women) developed AH. Among them, four had bilateral AH and two had rapidly increasing vitreous opacity that led to decreased vision. One patient was a 48-year-old woman with progressive AH in the left eye. After treatment with a vitrectomy, her vision improved from 0.4 to 0.8. The spherical particles were composed of mainly calcium and phosphorus.
  
  
  CONCLUSIONS
  The prevalence of AH in RP was higher than in previous reports, and we encountered two rare cases of progressive AH with decreased vision. We conclude that AH might lead to decreased vision in patients with RP.
authors.affiliation: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Toshio
authors.initials: T
authors.lastname: Hisatomi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murakami
authors.forename: Masanori
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Ri-ichiro
authors.initials: R
authors.lastname: Kohno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Hata
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000032:analysis; D005128:Eye Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017553:Phosphorus Compounds / Q000032:analysis; D015995:Prevalence; D012174:Retinitis Pigmentosa / Q000150:complications*; D012189:Retrospective Studies; D013052:Spectrometry, X-Ray Emission; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014821:Vitrectomy; D014822:Vitreous Body / Q000737:chemistry / Q000473:pathology*
chemical_list: D017553:Phosphorus Compounds; D002118:Calcium