[¹¹C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results.
OBJECTIVE
Based on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [(11)C]acetate PET.


METHODS
Two male patients were investigated 3 and 12 weeks after hip arthroplasty with muscle [(11)C]acetate PET/CT performed at rest and exercise. Median muscle SUV(mean) were calculated on three non-consecutive transverse PET slices.


RESULTS
The four exercise PET/CT showed, compared with rest, consistent increase in [(11)C]acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12 weeks after surgery, but four muscles showed only minor activity increase at 3 weeks. At 3 months, functional recovery of the latter four muscles was observed.


CONCLUSIONS
Consistent increase in [(11)C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation.
Buchegger
Franz
F
Service of Nuclear Medicine, University Hospital of Geneva, Geneva, Switzerland. Franz.Buchegger@hcuge.ch
Ratib
Osman
O
Willi
Jean-Pierre
JP
Steiner
Charles
C
Seimbille
Yann
Y
Zaidi
Habib
H
Graf
Véronique
V
Peter
Robin
R
Jung
Maximilien
M
D000085:Acetates / Q000493:pharmacokinetics; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D002250:Carbon Radioisotopes; D005081:Exercise Therapy; D006615:Hip / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D020127:Recovery of Function / Q000502:physiology; D012146:Rest; D014057:Tomography, X-Ray Computed
D000085:Acetates; D002250:Carbon Radioisotopes
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