title: Langerhans cell histiocytosis of the petrous bone with sudden sensorineural hearing loss. Case report.
abstract: A 56-year-old woman with Langerhans cell histiocytosis of the petrous bone presented with sudden onset of sensorineural hearing loss and vertigo without other neurological impairment, mimicking idiopathic sudden sensorineural hearing loss. Differential diagnosis was difficult until neuroimaging demonstrated a lesion of the petrous bone. The patient eventually underwent removal of the lesion via the transpetrosal approach, and received postoperative chemotherapy consisting of vinblastine, methotrexate, 6-mercaptopurine, and prednisolone. Although her hearing did not recover, complete remission was achieved, and the patient is currently free from disease. Physicians need to be aware that patients with sudden onset of hearing loss may have an unexpected and hidden disease which requires neuroimaging and histological examinations for definitive diagnosis and appropriate treatment.
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan. suzuhyde@med.uoeh-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Nobusuke
authors.initials: N
authors.lastname: Hohchi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Wakasugi
authors.forename: Minori
authors.initials: M
authors.lastname: Shibata
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ohkubo
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Tsukada
mesh_terms: D000208:Acute Disease; D001847:Bone Diseases / Q000150:complications* / Q000473:pathology / Q000628:therapy; D004359:Drug Therapy, Combination; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D010579:Petrous Bone / Q000473:pathology*; D016896:Treatment Outcome; D014717:Vertigo / Q000209:etiology* / Q000473:pathology