Purinergic signaling in cochleovestibular hair cells and afferent neurons.
Purinergic signaling in the mammalian cochleovestibular hair cells and afferent neurons is reviewed. The scope includes P2 and P1 receptors in the inner hair cells (IHCs) of the cochlea, the type I spiral ganglion neurons (SGNs) that convey auditory signals from IHCs, the vestibular hair cells (VHCs) in the vestibular end organs (macula in the otolith organs and crista in the semicircular canals), and the vestibular ganglion neurons (VGNs) that transmit postural and rotatory information from VHCs. Various subtypes of P2X ionotropic receptors are expressed in IHCs as well as P2Y metabotropic receptors that mobilize intracellular calcium. Their functional roles still remain speculative, but adenosine 5'-triphosphate (ATP) could regulate the spontaneous activity of the hair cells during development and the receptor potentials of mature hair cells during sound stimulation. In SGNs, P2Y metabotropic receptors activate a nonspecific cation conductance that is permeable to large cations as NMDG(+) and TEA(+). Remarkably, this depolarizing nonspecific conductance in SGNs can also be activated by other metabotropic processes evoked by acetylcholine and tachykinin. The molecular nature and the role of this depolarizing channel are unknown, but its electrophysiological properties suggest that it could lie within the transient receptor potential channel family and could regulate the firing properties of the afferent neurons. Studies on the vestibular partition (VHC and VGN) are sparse but have also shown the expression of P2X and P2Y receptors. There is still little evidence of functional P1 (adenosine) receptors in the afferent system of the inner ear.
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Hear Res. 1998 May;119(1-2):1-13
9641314
J Comp Neurol. 2005 Apr 4;484(2):133-43
15736235
Brain Res Dev Brain Res. 2001 Feb 28;126(2):173-82
11248351
Development. 2007 Apr;134(7):1407-17
17329369
Hear Res. 1999 Feb;128(1-2):190-6
10082298
Hear Res. 1994 Jun 1;76(1-2):87-100
7928720
J Neurophysiol. 2003 Sep;90(3):2069-73
12966182
Acta Otolaryngol. 2000 Sep;120(6):704-9
11099145
Eur J Neurosci. 2005 Jun;21(11):2912-22
15978003
Hear Res. 2005 Mar;201(1-2):132-44
15721568
J Neurosci. 1994 Nov;14(11 Pt 2):6992-7007
7965094
Hear Res. 2010 Aug;267(1-2):89-95
20430087
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H21-8
18502908
Neuropharmacology. 2002 Mar;42(3):386-95
11897117
Nature. 2007 Nov 1;450(7166):50-5
17972875
Trends Neurosci. 2009 Mar;32(3):128-41
19232752
Neurosci Lett. 2003 Feb 13;337(3):135-8
12536042
Cell Tissue Res. 2007 Jun;328(3):461-71
17285327
Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G604-16
12631560
Neuroreport. 1999 Aug 20;10(12):2579-86
10574373
Neuroreport. 1998 Jan 26;9(2):279-82
9507969
Nature. 2009 Oct 22;461(7267):1126-9
19847265
Hear Res. 2003 Jan;175(1-2):165-70
12527134
Audiol Neurootol. 2003 Jan-Feb;8(1):28-37
12566690
Histochem Cell Biol. 2006 Jun;125(6):681-92
16341871
J Biol Chem. 2005 Sep 9;280(36):32035-47
15994335
Neuroscience. 2005;130(2):485-96
15664705
Physiol Rev. 2002 Oct;82(4):1013-67
12270951
J Physiol. 1996 Mar 15;491 ( Pt 3):707-18
8815205
Hear Res. 1995 Apr;84(1-2):177-93
7642450
Acta Otolaryngol. 2009 Feb;129(2):116-26
18607956
J Neurophysiol. 2009 Sep;102(3):1821-33
19571200
Histochem Cell Biol. 2010 Feb;133(2):137-47
19882163
Acta Otolaryngol. 2009 Dec;129(12):1340-50
19922080
Acta Otolaryngol. 2009 Dec;129(12):1351-8
19922081
Neuroreport. 1991 Feb;2(2):69-72
1883987
J Neurosci. 2005 Apr 20;25(16):4052-61
15843607
J Physiol. 2003 Oct 15;552(Pt 2):525-33
14561834
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18724-9
16344488
Histochem Cell Biol. 2010 Apr;133(4):437-48
20229053
Eur J Neurosci. 2002 Dec;16(11):2095-102
12473077
J Assoc Res Otolaryngol. 2001 Dec;2(4):362-76
11833609
Neurosci Lett. 1993 Oct 1;160(2):185-9
8247351
J Comp Neurol. 1998 Apr 20;393(4):403-14
9550147
Acta Otolaryngol. 2008;128(12):1286-93
18607942
Hear Res. 1997 Nov;113(1-2):198-206
9387999
Hear Res. 1994 Aug;78(2):181-8
7982811
Hear Res. 1995 Oct;90(1-2):119-25
8974988
Am J Physiol Cell Physiol. 2002 May;282(5):C1121-35
11940528
J Comp Neurol. 2000 Jun 5;421(3):289-301
10813788
Neuroreport. 2003 May 6;14(6):817-23
12858039
Hear Res. 1995 Oct;90(1-2):106-118
8974987
Purinergic Signal. 2010 Jun;6(2):273-81
20806018
Int Tinnitus J. 2007;13(1):21-8
17691659
Acta Otolaryngol. 2001 Jan;121(1):10-5
11270486
Acta Otolaryngol. 2010 Feb;130(2):196-203
20095091
Nat Rev Neurosci. 2006 Jun;7(6):423-36
16715052
Hear Res. 2010 Feb;260(1-2):81-8
19995597
Hear Res. 2002 Aug;170(1-2):127-38
12208547
Acta Otolaryngol. 1997 Jul;117(4):545-52
9288210
Neuroreport. 2002 Oct 28;13(15):1979-84
12395104
Annu Rev Biochem. 2007;76:387-417
17579562
J Invest Dermatol. 2006 Sep;126(9):1982-93
16741513
J Histochem Cytochem. 2002 Nov;50(11):1435-42
12417608
Ann Otol Rhinol Laryngol. 1978 Mar-Apr;87(2 Pt 1):185-90
206175
Nature. 2004 Dec 9;432(7018):723-30
15483558
Acta Otolaryngol. 2009 Oct;129(10):1050-60
19065290
Hear Res. 2003 Sep;183(1-2):97-108
13679142
Brain Res. 2006 Aug 9;1104(1):55-63
16815340
J Assoc Res Otolaryngol. 2004 Mar;5(1):58-65
14976588
Hear Res. 2003 May;179(1-2):21-32
12742235
J Neurosci. 1999 Oct 1;19(19):8377-88
10493739
Cell Calcium. 2005 Sep-Oct;38(3-4):233-52
16098585