The effects of tertiary and quaternary infections on the epidemiology of dengue.
The epidemiology of dengue is characterised by irregular epidemic outbreaks and desynchronised dynamics of its four co-circulating virus serotypes. Whilst infection by one serotype appears to convey life-long protection to homologous infection, it is believed to be a risk factor for severe disease manifestations upon secondary, heterologous infection due to the phenomenon of Antibody-Dependent Enhancement (ADE). Subsequent clinical infections are rarely reported and, since the majority of dengue infections are generally asymptomatic, it is not clear if and to what degree tertiary or quaternary infections contribute to dengue epidemiology. Here we investigate the effect of third and subsequent infections on the transmission dynamics of dengue and show that although the qualitative patterns are largely equivalent, the system more readily exhibits the desynchronised serotype oscillations and multi-annual epidemic outbreaks upon their inclusion. More importantly, permitting third and fourth infections significantly increases the force of infection without resorting to high basic reproductive numbers. Realistic age-prevalent patterns and seroconversion rates are therefore easier reconciled with a low value of dengue's transmission potential if allowing for more than two infections; this should have important consequences for dengue control and intervention measures.
Wikramaratna
Paul S
PS
Department of Zoology, University of Oxford, Oxford, United Kingdom.
Simmons
Cameron P
CP
Gupta
Sunetra
S
Recker
Mario
M
D017677:Age Distribution; D003716:Dengue Virus / Q000145:classification* / Q000502:physiology*; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D019595:Severe Dengue / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D013997:Time Factors
Am J Trop Med Hyg. 1997 May;56(5):566-72
9180609
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7711-6
17460037
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2238-43
18250338
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):790-4
9892712
Southeast Asian J Trop Med Public Health. 2004 Dec;35(4):913-7
15916090
Philos Trans R Soc Lond B Biol Sci. 1999 Apr 29;354(1384):757-68
10365401
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9422-7
17517625
Am J Trop Med Hyg. 2003 Feb;68(2):191-202
12641411
PLoS One. 2009 Aug 26;4(8):e6763
19707544
Vaccine. 2004 Mar 12;22(9-10):1275-80
15003657
Am J Trop Med Hyg. 2001 Sep;65(3):180-3
11561700
Emerg Infect Dis. 2005 May;11(5):740-1
15898172
J Infect Dis. 2000 Jan;181(1):2-9
10608744
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Dec;72(6 Pt 2):066201
16486034
Am J Trop Med Hyg. 1988 Jan;38(1):172-80
3341519
Science. 1994 Feb 18;263(5149):961-3
8310293
Am J Trop Med Hyg. 1986 Nov;35(6):1263-79
3789275
Proc Biol Sci. 2009 Jul 22;276(1667):2541-8
19369266
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15259-64
16217017
Lancet. 2007 Apr 28;369(9571):1452-1459
17467515
J Infect Dev Ctries. 2009 Oct 26;3(9):711-22
19858573
Trop Med Int Health. 2006 Jun;11(6):935-42
16772016
Am J Trop Med Hyg. 2007 Nov;77(5):910-3
17984352
Am J Epidemiol. 1991 Jun 1;133(11):1168-78
2035520
PLoS Negl Trop Dis. 2009 Jul 21;3(7):e481
19621090
PLoS Med. 2009 Sep;6(9):e1000139
19721696
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14234-9
16966609
Parasite Immunol. 1994 Jul;16(7):361-70
7970875
Rev Saude Publica. 2003 Aug;37(4):477-84
12937709
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11802-7
16868086
Trop Med Int Health. 2006 Mar;11(3):332-40
16553913
Am J Trop Med Hyg. 2005 Feb;72(2):209-20
15741559
J Infect Dis. 1979 Oct;140(4):527-33
117061