Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.
BACKGROUND
Marked inter-individual variation has been observed with respect to the risk of weight gain and related metabolic disturbances during antipsychotic treatment, which in part could be explained by heritability. Such adverse effects have been proposed to occur through drug-induced mechanisms involving both the central nervous system and different peripheral tissues.


METHODS
We genotyped tagSNPs in several genes ( ADIPOQ, PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3, FTO and FABP3) that regulate lipid and energy homeostasis for their possible association to antipsychotic-induced weight gain.


RESULTS
In a sample of 160 patients of German origin with schizophrenia who had been monitored with respect to body weight, we found marked association between antipsychotic-related changes in BMI and 6 markers in the adiponectin gene ( ADIPOQ).


CONCLUSIONS
These findings support previous observations (in patients' serum) that adiponectin is involved in antipsychotic-mediated metabolic adverse effects.
Jassim
G
G
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Fernø
J
J
Theisen
F M
FM
Haberhausen
M
M
Christoforou
A
A
Håvik
B
B
Gebhardt
S
S
Remschmidt
H
H
Mehler-Wex
C
C
Hebebrand
J
J
Lehellard
S
S
Steen
V M
VM
D052242:Adiponectin / Q000235:genetics; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006706:Homeostasis / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
D052242:Adiponectin; D014150:Antipsychotic Agents; D005819:Genetic Markers