title: T2* magnetic resonance imaging sequences reflect brain tissue iron deposition following intracerebral hemorrhage.
abstract: OBJECTIVE
  To examine the utility of magnetic resonance imaging (MRI) T2* sequences as a measure of iron overload in the brain following intracerebral hemorrhage (ICH).
  
  
  METHODS
  We examined the time course of T2* changes in the brain around intracerebral hemorrhages in a series of patients. We also performed a series of experiments in an animal model of ICH, examining the time course of T2* changes along with correlation of these changes with histological markers of ferric iron deposition.
  
  
  RESULTS
  We found that T2* changes in the brain occur with increasing intensity and spatial distribution over a three month period. Experimental ICH in the rat model induces similar changes, and these changes correlate tightly with histological markers of ferric iron deposition.
  
  
  CONCLUSIONS
  MRI T2* changes after ICH can be used to measure the degree of iron overload in the brain. The T2* sequence may be useful as a measure of interventions aimed at reducing ICH-related brain injury by reducing iron deposition.
authors.affiliation: Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Guohua
authors.initials: G
authors.lastname: Xi
authors.forename: Ya
authors.initials: Y
authors.lastname: Hua
authors.forename: Oren
authors.initials: O
authors.lastname: Sagher
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