Noncationic dipeptide mimic oligomers as cell penetrating nonpeptides (CPNP).
Small oligomers of constrained dipeptide mimics have been synthesized as new vectors for intracellular delivery. They are highly internalized by cells and delivered to the lysosomes by an energy-dependent pathway. This new class of vectors referred to as cell penetrating nonpeptides (CPNP) possess the distinctive feature of being noncationic.
Vezenkov
Lubomir L
LL
Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Universités Montpellier 1 et 2, Montpellier, France.
Maynadier
Marie
M
Hernandez
Jean-François
JF
Averlant-Petit
Marie-Christine
MC
Fabre
Olivier
O
Benedetti
Ettore
E
Garcia
Marcel
M
Martinez
Jean
J
Amblard
Muriel
M
D001692:Biological Transport; D045744:Cell Line, Tumor; D004151:Dipeptides / Q000737:chemistry*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D057786:Peptidomimetics / Q000737:chemistry* / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D013841:Thiazepines / Q000737:chemistry
D004151:Dipeptides; D057786:Peptidomimetics; D011108:Polymers; D013841:Thiazepines