Effect of atorvastatin on chronic periodontitis: a randomized pilot study.
OBJECTIVE
We studied the effect of atorvastatin (ATV) treatment on bone loss prevention in subjects with chronic periodontitis.


METHODS
In this controlled double-blind study, 38 subjects with chronic periodontitis were randomized into two groups, paired by age to receive ATV (20 mg) or placebo daily for 3 months. Periodontal mechanical treatment was carried out in both groups at baseline. Clinical and radiographic parameters and bone turnover markers were assessed at baseline and at 3 months.


RESULTS
Periodontal disease conditions improved in both groups. After comparing the figures of change, significant improvements were observed in cholesterol levels (Δ=-58.5 ± 37.6 versusΔ=5.4 ± 41.2 mg/dl, p<0.0002), low-density lipoprotein levels (Δ=-48.1 ± 31.7 versusΔ=1.9 ± 42.8 mg/dl, p<0.002), dental mobility (Δ=-0.17 ± 0.11 versusΔ=-0.06 ± 0.11%, p<0.04), and the distance from the crestal alveolar bone to the cemento-enamel junction (Δ=-0.75 ± 0.7 versusΔ=0.09 ± 0.4 mm, p<0.0006) in the ATV group.


CONCLUSIONS
The results suggest that ATV might have beneficial effects on bone alveolar loss and tooth mobility in subjects with periodontal disease.
Fajardo
Martha Eugenia
ME
Department of Medical Sciences, University of Guanajuato, Leon, Mexico. eugeniafajardo@yahoo.com
Rocha
Miriam Lucía
ML
Sánchez-Marin
Francisco Javier
FJ
Espinosa-Chávez
Emanuel Jaime
EJ
D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000517:prevention & control*; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000069059:Atorvastatin; D055113:Chronic Periodontitis / Q000188:drug therapy*; D003773:Dental Plaque / Q000517:prevention & control; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D005889:Gingival Recession / Q000517:prevention & control; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011758:Pyrroles / Q000627:therapeutic use*; D019252:Radiography, Dental, Digital; D018709:Statistics, Nonparametric; D014086:Tooth Mobility / Q000517:prevention & control
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D008055:Lipids; D011758:Pyrroles; D000069059:Atorvastatin