title: [Quadrature coils for magnetic resonance spectroscopy in the detection of prostate cancer: single voxel acquisition does not improve the diagnostic accuracy of multivoxel images].
abstract: OBJECTIVE
  To determine the viability of quadrature coils for detecting prostate cancer using single voxel and multivoxel spectroscopy images.
  
  
  METHODS
  We used a quadrature coil on a 1.5T MR scanner to evaluate 23 patients with suspected prostate cancer and prostate specific antigen levels greater than 4ng/ml (mean 12±8ng/ml), independently of findings at digital rectal examination. We acquired T2-weighted images and MR spectroscopy images. We also acquired single voxel studies in areas in which the T2-weighted images or the multivoxel images were altered. We used a citrate solution to verify the spectroscopic calibration.
  
  
  RESULTS
  Using spectroscopy images and a (Co+Cr)/Cit cutoff of 1.40 in single voxel spectroscopy, we achieved a sensitivity of 92%, specificity of 55%, a negative predictive value of 86%, and a positive predictive value of 69%. Using a cutoff of 0.75 decreased specificity slightly (45%). The (Co+Cr)/Cit ratio calculated for the single volume obtained from the most abnormal area in the T2-weighted images and in the multivoxel spectroscopy slices was not significantly different between cancerous and non-cancerous tissues (ANOVA, p=0.1), although there was a clear trend toward increased coefficients with hyperplasia and neoplastic degeneration.
  
  
  CONCLUSIONS
  The quadrature coil enables multivoxel and single voxel spectroscopic images of clinically and technically acceptable quality to be obtained. Using single voxel spectroscopy does not improve the diagnostic performance of multivoxel spectroscopy and T2-weighted images.
authors.affiliation: CIBER, Bioingeniería, Biomateriales y Nanomedicina, ISCIII, Madrid, España.
authors.forename: M C
authors.initials: MC
authors.lastname: Martínez-Bisbal
authors.forename: B
authors.initials: B
authors.lastname: Martínez-Granados
authors.forename: A I
authors.initials: AI
authors.lastname: Catalá-Gregori
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
authors.forename: B
authors.initials: B
authors.lastname: Celda
authors.forename: L
authors.initials: L
authors.lastname: Martí-Bonmatí
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results