Anti-cocaine vaccine development.
Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At present, there are no effective pharmacological agents available to treat the addiction by blocking cocaine or reversing its effects. In order to help motivated addicts conquer their addiction, vaccines against cocaine are being developed and one has progressed to clinical trials. This article will discuss the concept of antidrug vaccines in general, the successes and limitations of the various anti-cocaine vaccine approaches, the results of the clinical trials with an anti-cocaine vaccine and some new vaccine-mediated approaches to combat cocaine addiction.
Kinsey
Berma M
BM
Veterans Affairs Medical Center, TX, USA.
Kosten
Thomas R
TR
Orson
Frank M
FM
D000569:Americas; D002986:Clinical Trials as Topic; D003042:Cocaine / Q000276:immunology*; D005060:Europe; D006801:Humans; D019966:Substance-Related Disorders / Q000517:prevention & control* / Q000628:therapy*; D014612:Vaccines / Q000276:immunology*
D014612:Vaccines; D003042:Cocaine
Neuropsychopharmacology. 2008 Oct;33(11):2715-25
18199998
JAMA. 1997 Dec 10;278(22):1895-906
9396651
Protein Eng Des Sel. 2010 Jul;23(7):537-47
20436035
J Addict Dis. 2010 Apr;29(2):200-16
20407977
Immunopharmacology. 1994 Jan-Feb;27(1):79-84
8206756
Biol Pharm Bull. 2005 Jun;28(6):1038-42
15930741
J Org Chem. 2001 Jun 15;66(12):4115-21
11397142
Biochemistry. 1964 Jul;3:996-1008
14214095
Chem Pharm Bull (Tokyo). 1995 Nov;43(11):1902-11
8575031
J Pharmacol Exp Ther. 2009 Aug;330(2):449-57
19478136
Hum Vaccin. 2009 Apr;5(4):206-13
19276653
Biol Psychiatry. 2005 Jul 15;58(2):158-64
16038686
Toxicol Appl Pharmacol. 1997 Aug;145(2):363-71
9266810
Nat Med. 1996 Oct;2(10):1129-32
8837612
Chem Biol Interact. 2010 Sep 6;187(1-3):421-4
20219449
Pharmacol Biochem Behav. 1997 Sep;58(1):215-20
9264094
Biol Psychiatry. 2010 Jan 1;67(1):59-65
19846066
Exp Clin Psychopharmacol. 2000 May;8(2):163-7
10843298
Addict Biol. 2007 Jun;12(2):133-51
17508985
Pharmacol Rev. 1973 Jun;25(2):281-91
4581045
Immunopharmacology. 1992 May-Jun;23(3):173-9
1500284
Biull Eksp Biol Med. 1993 Jun;115(6):645-6
7690618
Science. 1993 Mar 26;259(5103):1899-901
8456315
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1988-92
11172063
Ther Drug Monit. 2000 Jun;22(3):266-70
10850392
J Pharmacol Exp Ther. 2000 Jun;293(3):952-61
10869397
J Comput Aided Mol Des. 2008 Sep;22(9):661-71
17989928
Eur J Immunol. 2001 Dec;31(12):3816-24
11745403
Psychopharmacology (Berl). 2000 Feb;148(3):251-62
10755738
CA Cancer J Clin. 2005 Sep-Oct;55(5):281-99; quiz 322-3, 325
16166074
J Pharmacol Exp Ther. 2001 Mar;296(3):789-96
11181908
Arch Gen Psychiatry. 2009 Oct;66(10):1116-23
19805702
Expert Rev Vaccines. 2002 Oct;1(3):363-71
12901575
Bioorg Med Chem Lett. 2001 Jan 22;11(2):87-90
11206477
Curr Top Med Chem. 2001 Aug;1(3):175-82
11895133
Am J Psychiatry. 2005 Aug;162(8):1432-40
16055764
Nature. 1995 Dec 14;378(6558):727-30
7501020
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6202-6
10823960
Immunology. 2000 May;100(1):48-56
10809958
Vaccine. 2010 Mar 2;28(10):2161-2168
20060511
J Mol Biol. 2007 Jan 19;365(3):722-31
17084858
Vaccine. 2009 May 14;27(22):2981-8
19428909
Eur J Immunol. 2006 Mar;36(3):770-8
16435281
Psychopharmacology (Berl). 2001 Jan;153(3):334-40
11271406