title: Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain.
abstract: Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Tadasu
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsunoda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takasaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tabuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Uehara
authors.forename: Hiroko
authors.initials: H
authors.lastname: Itoh
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000818:Animals; D015870:Gene Expression; D005786:Gene Expression Regulation; D008297:Male; D009186:Myelin Sheath / Q000235:genetics*; D009836:Oligodendroglia; D020411:Oligonucleotide Array Sequence Analysis; D017397:Prefrontal Cortex / Q000254:growth & development*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics; D012741:Sexual Maturation / Q000235:genetics*
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