title: Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique.
abstract: After the removal of the giant cell tumor (GCT) of bone, it is necessary to fill the defects with adequate biomaterials. A new functional bone repair material with both stimulating osteoblast growth and inhibiting osteoclast activity has been developed with phosphorylated chitosan (P-chitosan) and disodium (1 --> 4)-2-deoxy-2-sulfoamino-beta-D-glucopyranuronan (S-chitosan) as the additives of poly(lactic acid-co-glycolic acid) (PLGA)/calcium phosphate (TCP) scaffolds based on a double-nozzle low-temperature deposition manufacturing technique. A computer-assisted design model was used and the optimal fabrication parameters were determined through the manipulation of a pure PLGA/TCP system. The microscopic structures, water absorbability and mechanical properties of the samples with different P-chitosan and S-chitosan concentrations were characterized correspondingly. The results suggested that this unique composite porous scaffold material is a potential candidate for the repair of large bone defects after a surgical removal of GCT.
authors.affiliation: Key Laboratory for Advanced Materials Processing Technology, Ministry of Education & Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Kai
authors.forename: Xinluan
authors.initials: X
authors.lastname: Wang
authors.forename: Kumta Shekhar
authors.initials: KS
authors.lastname: Madhukar
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.forename: Yongnian
authors.initials: Y
authors.lastname: Yan
authors.forename: Renji
authors.initials: R
authors.lastname: Zhang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000042:Absorption; D001859:Bone Neoplasms / Q000601:surgery / Q000628:therapy; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D048271:Chitosan; D017076:Computer-Aided Design; D018212:Giant Cell Tumor of Bone / Q000601:surgery / Q000628:therapy; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048271:Chitosan; C020243:calcium phosphate