Muscle contraction: A mechanical perspective.
In this paper we present a purely mechanical analog of the conventional chemo-mechanical modeling of muscle contraction. We abandon the description of kinetics of the power stroke in terms of jump processes and instead resolve the continuous stochastic evolution on an appropriate energy landscape. In general physical terms, we replace hard spin chemical variables by soft spin variables representing mechanical snap-springs. This allows us to treat the case of small and even disappearing barriers and, more importantly, to incorporate the mechanical representation of the power stroke into the theory of Brownian ratchets. The model provides the simplest non-chemical description for the main stages of the biochemical Lymn-Taylor cycle and may be used as a basis for the artificial micro-mechanical reproduction of the muscle contraction mechanism.
Marcucci
L
L
CNRS-UMR, Ecole Polytechnique, Palaiseau, France. lorenzo.marcucci@gmail.com
Truskinovsky
L
L
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D020134:Catalytic Domain; D003198:Computer Simulation; D004548:Elasticity; D004734:Energy Metabolism; D007551:Isotonic Contraction / Q000502:physiology; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D009132:Muscles / Q000737:chemistry / Q000378:metabolism*; D013269:Stochastic Processes; D013314:Stress, Mechanical; D013816:Thermodynamics
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate
Nat Cell Biol. 2002 Jan;4(1):59-65
11740494
Prog Biophys Mol Biol. 1978;33(1):55-82
146885
J Muscle Res Cell Motil. 1996 Aug;17(4):507-11
8884605
Ann N Y Acad Sci. 2005 Jun;1047:232-47
16093500
Adv Protein Chem. 2005;71:161-93
16230112
Phys Rev Lett. 1993 Sep 6;71(10):1477-1481
10054418
Phys Rev Lett. 2006 Jul 21;97(3):038101
16907545
J Theor Biol. 2000 May 7;204(1):67-82
10772849
Nature. 2002 Feb 7;415(6872):659-62
11832949
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13927-32
16172377
Pflugers Arch. 1996 Nov-Dec;433(1-2):1-8
9019709
Biochemistry. 1971 Dec 7;10(25):4617-24
4258719
Biophys J. 2003 Aug;85(2):818-27
12885630
Phys Rev Lett. 1994 Apr 18;72(16):2652-2655
10055938
Biophys J. 1995 Aug;69(2):524-37
8527667
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Dec;78(6 Pt 1):061131
19256826
Nature. 1954 May 22;173(4412):971-3
13165697
Nature. 1954 May 22;173(4412):973-6
13165698
Nature. 2002 Jan 10;415(6868):129-31
11805818
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2770-5
10077586
Prog Biophys Biophys Chem. 1957;7:255-318
13485191
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jul;74(1 Pt 1):011912
16907132
J Gen Physiol. 2004 Jun;123(6):643-56
15173218
Proc Biol Sci. 2010 Jan 7;277(1678):19-27
19812088
Biophys J. 1998 May;74(5):2459-73
9591672
J Physiol. 2002 Nov 15;545(1):145-51
12433956
Phys Rev Lett. 1994 Mar 14;72(11):1766-1769
10055695
Phys Rev Lett. 1994 May 9;72(19):2984-2987
10056038
Nature. 1971 Oct 22;233(5321):533-8
4939977
Biophys J. 1995 May;68(5):1966-79
7612839
Ann Biomed Eng. 2008 Oct;36(10):1624-40
18642081
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20114-9
18077437
Biophys J. 2006 Nov 1;91(9):3359-69
16891364
Phys Rev E Stat Nonlin Soft Matter Phys. 2010 May;81(5 Pt 1):051915
20866269
Biophys J. 1980 Feb;29(2):195-227
6455168