Four new sesquiterpenoids from the roots of Incarvillea arguta and their inhibitory activities against lipopolysaccharide-induced nitric oxide production.
Four new sesquiterpenoids, argutosines A-D (1-4), together with two known ones (5, 6), were isolated from the roots of Incarvillea arguta. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analysis. All the sesquiterpenoids were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Argutosines A, B and C (1-3) showed potent inhibitory activities with IC(50) values of 2.05, 0.55, and 9.87 microM, respectively.
Fu
Jian-Jun
JJ
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Qin
Jiang-Jiang
JJ
Zeng
Qi
Q
Huang
Ying
Y
Jin
Hui Zi
HZ
Zhang
Wei-Dong
WD
D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide