title: MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression.
abstract: OBJECTIVE
  To determine whether MRI and conventional (clinical and laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA).
  
  
  METHODS
  55 patients with RA with disease duration <1 year participated in this 3-year follow-up study. Patients were evaluated at baseline, 3, 6, 12 and 36 months by swollen and tender joint count, disease activity score based on 28-joint count, erythrocyte sedimentation rate (ESR), C reactive protein, MRI measures of synovitis, bone marrow oedema and tenosynovitis of the dominant wrist, as well as conventional x-rays of the hands and wrists.
  
  
  RESULTS
  All measures of inflammation decreased during the follow-up period. ESR, MRI synovitis and MRI bone marrow oedema were independent predictors of 3-year radiographic progression adjusted for age, sex and anti-citrullinated protein antibodies. The 1-year cumulative measures of MRI synovitis and bone marrow oedema provided an improved explanation of variation (adjusted R(2)) in radiographic change compared with the baseline MRI values (adjusted R(2)=0.32 and 0.20 vs 0.11 and 0.04, respectively).
  
  
  CONCLUSIONS
  Both baseline and 1-year cumulative measures of MRI synovitis and bone marrow oedema independently predicted 3-year radiographic progression. These results confirm that MRI synovitis and MRI bone marrow oedema precede radiographic progression in patients with early RA.
authors.affiliation: Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. pernilleboyesen@gmail.com
authors.forename: Pernille
authors.initials: P
authors.lastname: Bøyesen
authors.forename: Espen A
authors.initials: EA
authors.lastname: Haavardsholm
authors.forename: Mikkel
authors.initials: M
authors.lastname: Ostergaard
authors.forename: Désirée
authors.initials: D
authors.lastname: van der Heijde
authors.forename: Sølve
authors.initials: S
authors.lastname: Sesseng
authors.forename: Tore K
authors.initials: TK
authors.lastname: Kvien
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001855:Bone Marrow Diseases / Q000175:diagnosis* / Q000209:etiology; D018450:Disease Progression; D004487:Edema / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012720:Severity of Illness Index; D013585:Synovitis / Q000175:diagnosis* / Q000209:etiology