Obesity and diabetes genetic variants associated with gestational weight gain.
OBJECTIVE
We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain.


METHODS
A total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and obesity.


RESULTS
Among Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele carriers.


CONCLUSIONS
We found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain.
Stuebe
Alison M
AM
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. astuebe@med.unc.edu
Lyon
Helen
H
Herring
Amy H
AH
Ghosh
Joyee
J
Wise
Alison
A
North
Kari E
KE
Siega-Riz
Anna Maria
AM
D000328:Adult; D000483:Alleles; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D015992:Body Mass Index; D027682:Cation Transport Proteins; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008137:Longitudinal Studies; D015999:Multivariate Analysis; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D015430:Weight Gain; D044465:White People / Q000235:genetics; D000075703:Zinc Transporter 8; D001741:Black or African American
D027682:Cation Transport Proteins; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8
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