title: Structure of a stacked anthraquinone-DNA complex.
abstract: The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs.
authors.affiliation: Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Spain.
authors.forename: Daniela
authors.initials: D
authors.lastname: De Luchi
authors.forename: Isabel
authors.initials: I
authors.lastname: Usón
authors.forename: Glenford
authors.initials: G
authors.lastname: Wright
authors.forename: Catherine
authors.initials: C
authors.lastname: Gouyette
authors.forename: Juan A
authors.initials: JA
authors.lastname: Subirana
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D013237:Stereoisomerism
chemical_list: D000880:Anthraquinones; D004247:DNA
references.citation: Methods Enzymol. 1997;276:307-26
references.pmid: 27754618
references.citation: Acta Crystallogr B. 2002 Jun;58(Pt 3 Pt 1):380-8
references.pmid: 12037359
references.citation: J Med Chem. 2008 Sep 25;51(18):5566-74
references.pmid: 18754611
references.citation: J Med Chem. 1992 Apr 17;35(8):1418-29
references.pmid: 1573635
references.citation: J Biomol Struct Dyn. 1987 Dec;5(3):557-79
references.pmid: 2482757
references.citation: J Biol Inorg Chem. 2005 Aug;10(5):476-82
references.pmid: 15926069
references.citation: Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55
references.pmid: 15299926
references.citation: Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21
references.pmid: 9757107
references.citation: Biochemistry. 2000 Sep 12;39(36):10950-7
references.pmid: 10998231
references.citation: Nat Struct Biol. 1997 May;4(5):382-9
references.pmid: 9145109