NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.
Allergic airway inflammation is a disease in which T helper 2 (Th2) cells have a critical function. The molecular mechanisms controlling Th2 differentiation and function are of paramount importance in biology and immunology. Recently, a network of PB1-containing adapters and kinases has been shown to be essential in this process owing to its function in regulating cell polarity and the activation of critical transcription factors. Here, we show in vivo data showing that T-cell-specific NBR1-deficient mice show impaired lung inflammation and have defective Th2 differentiation ex vivo with alterations in T-cell polarity and the selective inhibition of Gata3 and nuclear factor of activated T c1 activation. These results establish NBR1 as a novel PB1 adapter in Th2 differentiation and asthma.
Yang
Jun-Qi
JQ
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Liu
Hongzhu
H
Diaz-Meco
Maria T
MT
Moscat
Jorge
J
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism*; D000534:Alum Compounds / Q000633:toxicity; D000818:Animals; D015153:Blotting, Western; D002454:Cell Differentiation / Q000276:immunology*; D016764:Cell Polarity / Q000276:immunology; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D050990:GATA3 Transcription Factor / Q000037:antagonists & inhibitors; D006801:Humans; D047468:Immunoprecipitation; D047908:Intracellular Signaling Peptides and Proteins; D019169:Jurkat Cells; D051379:Mice; D018345:Mice, Knockout; D050778:NFATC Transcription Factors / Q000378:metabolism; D010047:Ovalbumin / Q000633:toxicity; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000502:physiology*; D018418:Th2 Cells / Q000276:immunology* / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D000534:Alum Compounds; D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D050778:NFATC Transcription Factors; C486326:Nbr1 protein, mouse; D011506:Proteins; C446402:ovalbumin-alum; D010047:Ovalbumin
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