Flavonoid glycosides from Microtea debilis and their cytotoxic and anti-inflammatory effects.
Two new 5-O-glucosylflavones, 5-O-β-D-glucopyranosyl cirsimaritin (1) and 5, 4'-O-β-D-diglucopyranosyl cirsimaritin (2), four known flavonoids, cirsimarin (3), cirsimaritin (4), salvigenin (5), 4', 5-dihydroxy-7-methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages. Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC(50) values of 7.1, 13.1, 6.1, and 6.8 μM, respectively.
Bai
Naisheng
N
Naturex, Inc, 375 Huyler St, South Hackensack, NJ 07606, United States.
He
Kan
K
Roller
Marc
M
Lai
Ching-Shu
CS
Shao
Xi
X
Pan
Min-Hsiung
MH
Bily
Antoine
A
Ho
Chi-Tang
CT
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D056945:Hep G2 Cells; D006801:Humans; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D009573:Nitrites / Q000378:metabolism; D029602:Phytolaccaceae / Q000737:chemistry*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
C560460:5,4'-O-beta-D-diglucopyranosyl cirsimaritin; C560459:5-O-beta-D-glucopyranosyl cirsimaritin; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D005960:Glucosides; D008070:Lipopolysaccharides; D009573:Nitrites; D010936:Plant Extracts