title: Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome.
abstract: A percutaneous renal biopsy was performed on a 3-year-old female Japanese domestic cat with pleural effusion, mild azotemia, hypoalbuminemia, hypercholesterolemia, and proteinuria. Glomerular lesions included mild diffuse hypercellularity and numerous capsular adhesions with segmental sclerosis/hyalinosis of glomerular tufts. Electron microscopy revealed many subendothelial dense deposits with characteristic outer protrusion of glomerular basement membrane. Diffuse and global granular deposits of IgG and C3 were detected along the capillary walls. Tubulo-interstitial changes were mild at the time of biopsy, but progression of the disease was predicted because of the many capsular adhesions of the glomerular tufts. The cat was fed a prescription diet without any other specific or symptomatic therapy after renal biopsy, and died 43 weeks after the biopsy. At necropsy, extensive tubulo-interstitial fibrosis and mononuclear cell infiltration had developed throughout the cortex and outer medulla, and most glomeruli had extensive global sclerosis or obsolescence with less prominent depositions of IgG and C3.
authors.affiliation: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kamiie
authors.forename: Atsuko
authors.initials: A
authors.lastname: Haishima
authors.forename: Kaoru
authors.initials: K
authors.lastname: Inoue
authors.forename: Kikumi
authors.initials: K
authors.lastname: Ogihara
authors.forename: Mihoko
authors.initials: M
authors.lastname: Ono
authors.forename: Kyohei
authors.initials: K
authors.lastname: Yasuno
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Aihara
authors.forename: Tamio
authors.initials: T
authors.lastname: Ohmuro
authors.forename: Kinji
authors.initials: K
authors.lastname: Shirota
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology / Q000662:veterinary*; D009404:Nephrotic Syndrome / Q000473:pathology / Q000662:veterinary*; D051437:Renal Insufficiency / Q000473:pathology / Q000662:veterinary*