Arterial stiffness: a brief review.
Physical stiffening of the large arteries is the central paradigm of vascular aging. Indeed, stiffening in the larger central arterial system, such as the aortic tree, significantly contributes to cardiovascular diseases in older individuals and is positively associated with systolic hypertension, coronary artery disease, stroke, heart failure and atrial fibrillation, which are the leading causes of mortality in the developed countries and also in the developing world as estimated in 2010 by World Health Organizations. Thus, better, less invasive and more accurate measures of arterial stiffness have been developed, which prove useful as diagnostic indices, pathophysiological markers and predictive indicators of disease. This article presents a review of the structural determinants of vascular stiffening, its pathophysiologic determinants and its implications for vascular research and medicine. A critical discussion of new techniques for assessing vascular stiffness is also presented.
Shirwany
Najeeb A
NA
Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, 73104, USA.
Zou
Ming-hui
MH
D000375:Aging / Q000502:physiology; D000818:Animals; D001158:Arteries / Q000378:metabolism / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D003935:Diagnostic Techniques, Cardiovascular; D004032:Diet; D004548:Elasticity; D004730:Endothelium, Vascular / Q000503:physiopathology; D005947:Glucose / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D009490:Neurosecretory Systems / Q000503:physiopathology; D012307:Risk Factors; D014655:Vascular Resistance
D007328:Insulin; D005947:Glucose
Ageing Res Rev. 2002 Feb;1(1):1-15
12039445
J Biol Chem. 1994 Apr 1;269(13):9889-97
8144582
J Hypertens Suppl. 1996 Dec;14(5):S147-57
9120672
J Vasc Surg. 1994 Mar;19(3):426-34
8126855
Circ Res. 2000 Feb 18;86(3):E50-4
10679490
Hypertension. 2004 Jul;44(1):22-4
15173129
Vasc Med. 1999;4(3):181-6
10512598
Ann Biomed Eng. 1984;12(2):119-34
6439084
Kidney Int Suppl. 2003 Nov;(87):S24-31
14531770
Hum Mol Genet. 1999 Dec;8(13):2551-5
10556304
J Clin Invest. 1996 Dec 1;98(11):2572-9
8958220
Hypertension. 2005 Apr;45(4):652-8
15699456
J Appl Physiol (1985). 2008 Nov;105(5):1632-42
18719233
Arterioscler Thromb Vasc Biol. 2005 May;25(5):932-43
15731494
Hypertension. 2003 Feb;41(2):378-81
12574111
Circ Res. 1964 May;14:400-13
14156860
Diabetologia. 1996 Oct;39(10):1131-9
8896999
QJM. 2002 Feb;95(2):67-74
11861952
Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2021-6
12958045
J Clin Pathol. 2001 Feb;54(2):139-45
11215283
JAMA. 1999 Feb 17;281(7):634-9
10029125
Circulation. 1998 Dec 1;98(22):2453-60
9832492
Stroke. 2003 Jul;34(7):1623-7
12791939
Am J Hypertens. 1998 Jul;11(7):856-60
9683048
Circulation. 2002 Nov 26;106(22):2848-53
12451013
Am J Hypertens. 2005 Jan;18(1 Pt 2):3S-10S
15683725
Circulation. 1997 Jul 1;96(1):308-15
9236450
Circulation. 2003 Jan 21;107(2):346-54
12538439
Hypertension. 1998 May;31(5):1083-7
9576118
Curr Atheroscler Rep. 2000 Sep;2(5):430-6
11122775
Hypertension. 2001 Dec 1;38(6):1461-6
11751736
Hypertension. 2001 Sep;38(3):444-8
11566920
Curr Atheroscler Rep. 2002 May;4(3):228-37
11931721
Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2566-72
11116054
Hypertension. 2003 Sep;42(3):322-8
12874090
J Am Coll Cardiol. 1999 Dec;34(7):2007-14
10588217
Exp Gerontol. 2004 Feb;39(2):249-54
15036419
Mech Ageing Dev. 2001 May 31;122(7):735-55
11322995
Am J Hypertens. 1997 Dec;10(12 Pt 1):1326-34
9443767
N Engl J Med. 1999 Jan 7;340(1):14-22
9878640
Am J Pathol. 1991 Nov;139(5):1119-29
1951629
Circulation. 1996 Aug 15;94(4):698-703
8772690
Hypertension. 1995 Sep;26(3):503-8
7649589
Hippokratia. 2009 Apr;13(2):70-5
19561773
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):29-33
14551151
Circulation. 1995 Apr 1;91(7):1981-7
7895356
J Clin Invest. 1997 Sep 1;100(5):1230-9
9276741
Hypertension. 2000 Oct;36(4):477-83
11040222
Circ Res. 1995 Nov;77(5):863-8
7554139
Am J Hypertens. 2001 Aug;14(8 Pt 1):755-60
11497190
Circulation. 1994 Aug;90(2):669-76
8044936
Physiol Res. 2000;49(1):11-8
10805400
J Am Coll Cardiol. 2004 Apr 21;43(8):1388-95
15093872
Circ Res. 2003 May 2;92(8):827-39
12730128
J Hypertens. 1998 Jan;16(1):31-5
9533414
J Biol Chem. 2000 Dec 15;275(50):39027-31
10976109
Diabetologia. 2001 Apr;44(4):433-6
11357473
Physiol Rev. 1993 Apr;73(2):413-67
8475195
Tohoku J Exp Med. 1996 Oct;180(2):115-30
9111761
Am J Hypertens. 2001 Aug;14(8 Pt 1):798-803
11497197
Circulation. 2005 Jun 28;111(25):3384-90
15967850
Circ J. 2006 Oct;70(10):1231-9
16998252
J Biomech Eng. 1998 Oct;120(5):602-7
10412437
J Am Coll Cardiol. 2001 Mar 15;37(4):975-84
11263624
Hypertension. 1986 Jul;8(7):553-9
3013773
Circ Res. 2002 Feb 22;90(3):251-62
11861412
J Physiol. 2000 May 15;525 Pt 1:263-70
10811742
Am J Cardiol. 2001 Nov 1;88(9):980-6
11703993
Genet Epidemiol. 2001 Apr;20(3):373-82
11255245
Circulation. 1997 Mar 4;95(5):1132-7
9054841
Kidney Int. 1995 Jul;48(1):111-7
7564067
Hypertension. 1996 Dec;28(6):1081-4
8952600
Circulation. 2004 Feb 10;109(5):594-600
14769680
Circulation. 2003 Jan 28;107(3):490-7
12551876
Hypertension. 2001 Jun;37(6):1429-33
11408390
Heart Fail Rev. 2002 Jan;7(1):51-62
11790922
Eur Heart J. 2006 Nov;27(21):2588-605
17000623
J Appl Physiol (1985). 2008 Nov;105(5):1652-60
18772322
Lancet. 2001 Oct 27;358(9291):1400-4
11705484
Circulation. 1997 Dec 16;96(12):4254-60
9416890
Ann N Y Acad Sci. 1992 Nov 21;663:63-70
1482102
Circulation. 1999 Jul 27;100(4):354-60
10421594
JAMA. 2007 Feb 21;297(7):709-15
17312290