[Potentialities of non-invasive diagnosis of liver cirrhosis in children with the use of serological markers].
The study included 95 children with chronic hepatic disorders of different etiology. All of them underwent hepatic puncture biopsy for morphological studies and calculation of histological sclerosis index based on the Knoddel scale. Commercial enzyme immunoassay kits were used to measure hyaluronic acid (HA), type IV collagen (CIV), matrix metalloproteinase-1 (MMP-2), transforming growth factor-beta 1 (TGF), and leptin levels as non-invasive markers of fibrosis. It was shown that concentrations of TGF and MMP-2 at early stages of hepatic fibrosis, HA and CIV at its later stages are of diagnostic value.
Surkov
A N
AN
Kucherenko
A G
AG
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D024141:Collagen Type IV / Q000097:blood; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007223:Infant; D020738:Leptin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D012680:Sensitivity and Specificity; D053773:Transforming Growth Factor beta1 / Q000097:blood
D015415:Biomarkers; D024141:Collagen Type IV; D020738:Leptin; D053773:Transforming Growth Factor beta1; D006820:Hyaluronic Acid; D020778:Matrix Metalloproteinase 2