title: Prognostic value of baseline C-reactive protein levels in patients undergoing coronary revascularization.
abstract: BACKGROUND
  C-reactive protein (CRP) is a lowly expressed marker for inflammatory response. This study aimed to evaluate the prognostic value of baseline CRP levels in patients undergoing coronary revascularization in the context of modern medical treatment.
  
  
  METHODS
  This was a retrospective study in a single center. Four hundred and fourteen patients were enrolled, who underwent coronary revascularization and received adequate medication for secondary prevention of coronary heart disease. The study compared the follow-up clinical outcomes between high level CRP group (CRP > 5 mg/L) and low level one. The median follow-up time was 551 days.
  
  
  RESULTS
  Compared with low CRP group, the relative risk (RR) of the major adverse cardiovascular and cerebral events (MACCE) in high CRP group was 5.131 (95%CI: 1.864-14.123, P = 0.002). There were no significant differences in death, myocardial infarction and stroke during the follow-up between two groups, but a higher risk of re-revascularization was found in high CRP group (RR 6.008, 95%CI: 1.667-21.665, P = 0.006). Cox regression analysis showed that only CRP level could contribute to MACCE during the follow-up. MACCE-free rate was much lower in high CRP group (Kaplan-Meier log-rank P < 0.001).
  
  
  CONCLUSIONS
  In the context of modern medical treatment, the baseline level of CRP is an independent predictor for long-term prognosis in patients with coronary revascularization.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lü
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Kang
authors.forename: Jian-Zeng
authors.initials: JZ
authors.lastname: Dong
authors.forename: Cheng-Xiong
authors.initials: CX
authors.lastname: Gu
authors.forename: Fang-Jiong
authors.initials: FJ
authors.lastname: Huang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Lü
authors.forename: Xue-Si
authors.initials: XS
authors.lastname: Wu
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Ma
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein