Postoperative recurrence as an associated factor of malignant transformation of oral dysplastic leukoplakia.
OBJECTIVE
To evaluate the clinically associated factors of malignant transformation in patients who received laser surgery for oral dysplastic leukoplakia.


METHODS
The clinicopathological data of patients receiving laser surgery for dysplastic leukoplakia from 2002 to 2008 and HPV genomic DNA extracted from paraffin-embedded specimens were analyzed statistically.


RESULTS
A total 114 patients, 90 males and 24 females with an average age of 49.7 ± 12.2 years were enrolled. The follow-up period ranged from 1.07 to 7.43 years (mean 3.4 ± 1.3 years). Thirteen cases had malignant transformation (11.4%). Multiple-focus lesions, non-homogeneous leukoplakia, high-grade dysplasia and recurrence after laser treatment were significant factors in univariate analysis. Multivariate analysis showed that recurrence (relative risk = 9.40) was the independent prognostic factor for malignant transformation.


CONCLUSIONS
Recurrence after laser treatment is an independent prognostic factor predicting malignant transformation of dysplastic oral leukoplakia.
Yang
Shih-Wei
SW
Department of Otolaryngology, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China. sweeyang @ gmail.com
Wu
Chang-Jer
CJ
Lee
Yun-Shien
YS
Chen
Tai-An
TA
Tsai
Chi-Neu
CN
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000706:statistics & numerical data; D054020:Lasers, Gas; D007972:Leukoplakia, Oral / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology*; D018307:Neoplasms, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors