title: Neuroadipology: a novel component of neuroendocrinology.
abstract: Adipose tissue is a dynamic endocrine and paracrine organ producing a large number of signalling proteins collectively termed adipokines. Some of them are mediators in the cross-talk between adipose tissue and the brain in regulating food intake and energy homoeostasis. However, the hypothalamus is not the only brain target for adipokines, and food intake is not the only biological effect of these signals. Rather, some adipokines support various cognitive functions and exert neurotrophic activity. Current data on adipose-derived neuropeptides, neurotrophic factors, pituitary hormones and hypothalamic releasing factors is highlighted in this review. We propose that adipose tissue is a member of the diffuse neuroendocrine system. Cumulatively, this is conceptualized as neuroadipology, a new example of a link between neurobiology and other topics, such as neuroimmunology and neuroendocrinology. Because adipose tissue is a bona fide endocrine organ, neuroadipology may be considered a new discipline in neuroendocrinology. It may have a wide-ranging potential within a variety of neuronal and metabolic functions in health and disease.
authors.affiliation: Division of Cell Biology, Medical University, Varna, Bulgaria. chaldakov@yahoo.com
authors.forename: George N
authors.initials: GN
authors.lastname: Chaldakov
authors.forename: Marco
authors.initials: M
authors.lastname: Fiore
authors.forename: Anton B
authors.initials: AB
authors.lastname: Tonchev
authors.forename: Luigi
authors.initials: L
authors.lastname: Aloe
mesh_terms: D054392:Adipokines / Q000502:physiology; D000273:Adipose Tissue / Q000502:physiology*; D001921:Brain / Q000502:physiology; D003071:Cognition; D004435:Eating; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009452:Neuroendocrinology; D015213:Neuroimmunomodulation; D009479:Neuropeptides / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology*; D010906:Pituitary Hormone-Releasing Hormones / Q000502:physiology; D010907:Pituitary Hormones / Q000502:physiology; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D009414:Nerve Growth Factors; D009479:Neuropeptides; D010906:Pituitary Hormone-Releasing Hormones; D010907:Pituitary Hormones