title: Age at onset of puberty predicts bone mass in young adulthood.
abstract: OBJECTIVE
  To determine whether the commencement and length of puberty influences dual x-ray absorptiometry (DXA) values of bone mineral content (BMC) and bone mineral density (BMD) in the axial and appendicular skeleton at skeletal maturity.
  
  
  METHODS
  From the Bone Mineral Density in Childhood Study, we identified children who began puberty and completed sexual and skeletal development and examined whether the timing and length of puberty influence DXA values of BMC and BMD at skeletal maturity.
  
  
  RESULTS
  A total of 78 girls and 85 boys began puberty and completed skeletal maturity; 4.4 ± 0.8 and 4.5 ± 0.8 years later, respectively. Multiple linear regression analyses indicated that the age of onset of puberty was a strong negative predictor of DXA bone measurements at skeletal maturity, independent of bone values at the beginning of puberty, and the length of puberty. This negative relation was observed for all BMC and BMD measurements at all skeletal sites, in both boys and girls (all P < .0001). In contrast, length of puberty had no relation to any measures of bone.
  
  
  CONCLUSIONS
  In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty.
authors.affiliation: Children's Hospital Los Angeles, Department of Radiology, Los Angeles, CA 90027, USA. vgilsanz@chla.usc.edu
authors.forename: Vicente
authors.initials: V
authors.lastname: Gilsanz
authors.forename: James
authors.initials: J
authors.lastname: Chalfant
authors.forename: Heidi
authors.initials: H
authors.lastname: Kalkwarf
authors.forename: Babette
authors.initials: B
authors.lastname: Zemel
authors.forename: Joan
authors.initials: J
authors.lastname: Lappe
authors.forename: Sharon
authors.initials: S
authors.lastname: Oberfield
authors.forename: John
authors.initials: J
authors.lastname: Shepherd
authors.forename: Tishya
authors.initials: T
authors.lastname: Wren
authors.forename: Karen
authors.initials: K
authors.lastname: Winer
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D015519:Bone Density; D002648:Child; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011627:Puberty; D055815:Young Adult
references.citation: Osteoporos Int. 1996;6(2):141-8
references.pmid: 8704353
references.citation: J Clin Endocrinol Metab. 2000 Mar;85(3):1032-7
references.pmid: 10720035
references.citation: Horm Res. 1998;50(6):309-14
references.pmid: 9973670
references.citation: J Clin Invest. 1994 Feb;93(2):799-808
references.pmid: 8113412
references.citation: N Engl J Med. 1997 Jul 10;337(2):91-5
references.pmid: 9211678
references.citation: J Bone Miner Res. 2005 Jul;20(7):1228-34
references.pmid: 15940377
references.citation: J Bone Miner Res. 2006 May;21(5):790-5
references.pmid: 16734395
references.citation: J Pediatr Endocrinol Metab. 2000 Jun;13(6):591-7
references.pmid: 10905382
references.citation: N Engl J Med. 2003 Mar 6;348(10):908-17
references.pmid: 12621135
references.citation: Calcif Tissue Int. 1988 Oct;43(4):260-2
references.pmid: 3145132
references.citation: J Pediatr. 1995 May;126(5 Pt 1):683-9
references.pmid: 7751989
references.citation: Nutr Rev. 1981 Feb;39(2):43-55
references.pmid: 7010232
references.citation: J Clin Endocrinol Metab. 1995 Dec;80(12):3689-98
references.pmid: 8530621
references.citation: South Med J. 2001 Jun;94(6):569-73
references.pmid: 11440324
references.citation: J Clin Endocrinol Metab. 1996 Mar;81(3):1152-5
references.pmid: 8772591
references.citation: J Clin Endocrinol Metab. 2004 Sep;89(9):4306-11
references.pmid: 15356025
references.citation: Adolesc Med. 2002 Feb;13(1):53-72, vi
references.pmid: 11841955
references.citation: Osteoporos Int. 2006;17(7):971-7
references.pmid: 16601918
references.citation: Osteoporos Int. 2007 Mar;18(3):369-74
references.pmid: 17077943
references.citation: J Clin Endocrinol Metab. 2007 Jun;92(6):2087-99
references.pmid: 17311856
references.citation: J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):345-56
references.pmid: 14623531
references.citation: J Clin Endocrinol Metab. 2000 Oct;85(10):3908-18
references.pmid: 11061556
references.citation: N Engl J Med. 1994 Oct 20;331(16):1056-61
references.pmid: 8090165
references.citation: Endocrinol Metab Clin North Am. 2003 Mar;32(1):39-63
references.pmid: 12699292
references.citation: Pediatrics. 2002 Jan;109(1):45-60
references.pmid: 11773541
references.citation: N Engl J Med. 1992 Feb 27;326(9):600-4
references.pmid: 1734250
references.citation: J Clin Endocrinol Metab. 2009 Sep;94(9):3424-31
references.pmid: 19531591