title: An eye for discovery.
abstract: Vision research has often led to significant advances in our understanding of biology. There has also been particular success in translating basic research in the eye into breakthrough clinical therapies that mark important milestones for ophthalmology and also for medical research. Anti-VEGF therapy for age-related macular degeneration was named as one of the top ten science advancements of the year 2006. Only two years later, successful transfer of the RPE65 gene into retinal pigment epithelium of patients with Leber congenital amaurosis was noted as one of the most important clinical applications of gene therapy. The articles in this Review series outline current developments in vision research and highlight its continued importance in ophthalmology and medicine.
authors.affiliation: Department of Ophthalmology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stahl
authors.forename: Lois E H
authors.initials: LE
authors.lastname: Smith
mesh_terms: D000375:Aging; D005128:Eye Diseases / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D009885:Ophthalmology / Q000639:trends*; D057905:Stem Cell Research; D033581:Stem Cell Transplantation; D014793:Visual Cortex / Q000502:physiology; D014796:Visual Perception
references.citation: N Engl J Med. 2006 Oct 5;355(14):1419-31
references.pmid: 17021318
references.citation: J Clin Invest. 2010 Sep;120(9):3073-83
references.pmid: 20811163
references.citation: Science. 2006 Dec 22;314(5807):1850-5
references.pmid: 17185566
references.citation: J Clin Invest. 2010 Sep;120(9):3054-63
references.pmid: 20811161
references.citation: J Clin Invest. 2006 Dec;116(12):3266-76
references.pmid: 17111048
references.citation: Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10457-61
references.pmid: 7479819
references.citation: Proc Natl Acad Sci U S A. 1996 May 14;93(10):4851-6
references.pmid: 8643492
references.citation: J Clin Invest. 2010 Sep;120(9):3012-21
references.pmid: 20811157
references.citation: Clin Biochem. 2006 Mar;39(3):249-58
references.pmid: 16332362
references.citation: J Clin Invest. 2003 Apr;111(8):1171-80
references.pmid: 12697736
references.citation: J Clin Invest. 2004 Sep;114(6):765-74
references.pmid: 15372100
references.citation: Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2542-6
references.pmid: 16723468
references.citation: Br J Exp Pathol. 1948 Feb;29(1):58-69
references.pmid: 18865105
references.citation: Lancet. 1980 Apr 26;1(8174):896-8
references.pmid: 6103257
references.citation: J Clin Invest. 2010 Sep;120(9):3064-72
references.pmid: 20811162
references.citation: Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1231-7
references.pmid: 1973155
references.citation: Arch Ophthalmol. 1967 Mar;77(3):405-9
references.pmid: 4960032
references.citation: Br J Ophthalmol. 1996 Jan;80(1):9-14
references.pmid: 8664242
references.citation: Arch Ophthalmol. 2007 Jan;125(1):30-7
references.pmid: 17210849
references.citation: N Engl J Med. 2006 Oct 5;355(14):1474-85
references.pmid: 17021323
references.citation: J Clin Invest. 2010 Sep;120(9):3042-53
references.pmid: 20811160
references.citation: Arch Ophthalmol. 1996 Jan;114(1):66-71
references.pmid: 8540853
references.citation: J Clin Invest. 2010 Sep;120(9):3033-41
references.pmid: 20811159
references.citation: Arch Ophthalmol. 2004 Apr;122(4):598-614
references.pmid: 15078679
references.citation: Arch Ophthalmol. 2004 Apr;122(4):477-85
references.pmid: 15078664
references.citation: Nature. 2005 Jun 23;435(7045):1102-7
references.pmid: 15973409
references.citation: N Engl J Med. 2008 May 22;358(21):2240-8
references.pmid: 18441370
references.citation: N Engl J Med. 2006 Oct 5;355(14):1432-44
references.pmid: 17021319
references.citation: Arch Ophthalmol. 2007 Jan;125(1):74-9
references.pmid: 17210855
references.citation: Ophthalmol Clin North Am. 2003 Dec;16(4):639-45
references.pmid: 14741004
references.citation: Acta Physiol Scand. 1966 Jun;67(2):201-7
references.pmid: 5963406
references.citation: Bull World Health Organ. 2004 Nov;82(11):844-51
references.pmid: 15640920
references.citation: J Clin Invest. 2010 Sep;120(9):3022-32
references.pmid: 20811158
references.citation: N Engl J Med. 2008 May 22;358(21):2231-9
references.pmid: 18441371
references.citation: Science. 2002 Feb 8;295(5557):1077-9
references.pmid: 11834836
references.citation: Nat Med. 2008 Oct;14(10):1067-76
references.pmid: 18836459