title: Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.
abstract: OBJECTIVE
  To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS).
  
  
  METHODS
  DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every 6 months in DPPOS for a median 10.0-year follow-up.
  
  
  RESULTS
  Controlled for factors associated with diabetes risk, continuous antidepressant use compared with no use was associated with diabetes risk in the placebo (adjusted hazard ratio 2.34 [95% CI 1.32-4.15]) and lifestyle (2.48 [1.45-4.22]) arms, but not in the metformin arm (0.55 [0.25-1.19]).
  
  
  CONCLUSIONS
  Continuous antidepressant use was significantly associated with diabetes risk in the placebo and lifestyle arms. Measured confounders and mediators did not account for this association, which could represent a drug effect or reflect differences not assessed in this study between antidepressant users and nonusers.
authors.affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. dppmail@biostat.bsc.gwu.edu
authors.forename: Richard R
authors.initials: RR
authors.lastname: Rubin
authors.forename: Yong
authors.initials: Y
authors.lastname: Ma
authors.forename: Mark
authors.initials: M
authors.lastname: Peyrot
authors.forename: David G
authors.initials: DG
authors.lastname: Marrero
authors.forename: David W
authors.initials: DW
authors.lastname: Price
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
authors.forename: William C
authors.initials: WC
authors.lastname: Knowler
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans
chemical_list: D000928:Antidepressive Agents
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