The role of Helicobacter pylori infection in skin diseases: facts and controversies.
Helicobacter pylori is a Gram-negative bacterium that is considered a causative agent of peptic ulcer disease, gastric lymphoma, and gastric carcinoma. H pylori triggers an intense leucocyte infiltration of the gastric submucosa, an action that is mediated by proinflammatory cytokines. Because this pathogenetic mechanism is common to many other diseases, H pylori seroprevalence has also been investigated in other diseases. H pylori seropositivity is associated with various dermatologic disorders. Although the precise role of H pylori is unknown in these diseases, the organism can be eradicated, using simple and reliable drug regimens. This contribution highlights the dermatologic diseases associated with H pylori seropositivity.
Tüzün
Yalçin
Y
Department of Dermatology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. yalcintuzun@yahoo.com
Keskin
Sadiye
S
Kote
Eneida
E
D001528:Behcet Syndrome / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D002908:Chronic Disease; D005260:Female; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D012393:Rosacea / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D016036:Seroepidemiologic Studies; D017192:Skin Diseases, Bacterial / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D014581:Urticaria / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology