title: Phosphatase activity controls the ups and downs of cerebellar learning.
abstract: Investigations of the cellular substrate for cerebellar learning have focused largely on a single form of plasticity, kinase-dependent long-term depression (LTD). In this issue of Neuron, Schonewille et al. provide evidence that calcineurin, a protein phosphatase required for long-term potentiation (LTP) and other cellular processes, may be just as important.
authors.affiliation: Champalimaud Neuroscience Programme, Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, P-2780-156 Oeiras, Portugal. mcarey@ineurophd.org
authors.forename: Megan R
authors.initials: MR
authors.lastname: Carey
authors.forename: Wade G
authors.initials: WG
authors.lastname: Regehr