Risk of dementia associated with elevated plasma homocysteine in a latin american population.
The relationship between total homocysteine (tHcy) and dementia risk remains controversial, as the association varies among populations and dementia subtypes. We studied a Venezuelan population that has high prevalence of both elevated tHcy and dementia. We tested the hypotheses that (1) elevated tHcy is associated with increased dementia risk, (2) the risk is greater for vascular dementia (VaD) than for Alzheimer's disease (AD), and (3) a history of stroke may partly explain this association. 2100 participants (>/=55 years old) of the Maracaibo Aging Study underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. Elevated tHcy was significantly associated with dementia, primarily VaD. When history of stroke and other confounding factors were taken into account, elevated tHcy remained a significant risk factor in older (>66 years), but not in younger (55-66 years) subjects. Ongoing studies of this population may provide insight into the mechanism by which tHcy increases risk for dementia.
Chacón
Inara J
IJ
Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
Molero
Aldrín E
AE
Pino-Ramírez
Gloria
G
Luchsinger
José A
JA
Lee
Joseph H
JH
Maestre
Gladys E
GE
J Lipid Res. 1990 Mar;31(3):545-8
2341813
Neurology. 2004 Jun 8;62(11):1972-6
15184599
Neuroepidemiology. 2002 Jul-Aug;21(4):194-201
12065882
Lancet. 1995 Nov 25;346(8987):1395-8
7475822
Dement Geriatr Cogn Disord. 2003;16(4):269-75
14512723
Neurology. 1992 Mar;42(3 Pt 1):473-80
1549205
Neurology. 1984 Jul;34(7):939-44
6610841
Free Radic Biol Med. 2004 Jun 15;36(12):1532-41
15182855
J Neurosci Res. 2005 Jun 15;80(6):869-76
15898106
N Engl J Med. 1998 Apr 9;338(15):1042-50
9535670
J Chromatogr. 1987 Nov 27;422:43-52
3437026
Clin Biochem. 2006 Oct;39(10):1007-15
16959233
Clin Biochem. 2007 Aug;40(12):859-63
17532313
Semin Vasc Med. 2005 May;5(2):110-23
16047264
Arch Latinoam Nutr. 2007 Mar;57(1):26-32
17824196
Arch Gerontol Geriatr. 2009 Mar-Apr;48(2):142-5
18221800
Atherosclerosis. 2004 Oct;176(2):337-44
15380457
Lancet. 2007 Jun 2;369(9576):1876-1882
17544768
Neurology. 2002 May 28;58(10):1471-5
12034781
N Engl J Med. 2002 Feb 14;346(7):476-83
11844848
Bone. 2007 Mar;40(3):730-6
17141597
J Nutr. 2006 Jun;136(6 Suppl):1731S-1740S
16702348
Nutr Rev. 1999 Jan;57(1):25-31
10047703
Am J Clin Nutr. 2007 Feb;85(2):511-7
17284751
Curr Opin Psychiatry. 2007 Jul;20(4):380-5
17551353
Neurodegener Dis. 2005;2(6):299-304
16909012
JAMA. 2004 Feb 4;291(5):565-75
14762035
Ann Neurol. 1995 Feb;37(2):254-9
7847867
Am J Med. 2005 Feb;118(2):161-7
15694902
Neurol Sci. 2007 Oct;28(5):259-63
17972040
JAMA. 1993 Dec 8;270(22):2693-8
8133587
J Neurol Sci. 2004 Mar 15;218(1-2):109-14
14759642
Am J Psychiatry. 2001 Jun;158(6):848-56
11384888
J Vasc Surg. 2005 May;41(5):853-60
15886671
Stroke. 2002 Oct;33(10):2351-6
12364720
Arch Gerontol Geriatr. 2005 Mar-Apr;40(2):139-46
15680498
Arch Neurol. 2008 May;65(5):642-9
18474741
Neuroepidemiology. 2007;29(1-2):107-12
17940342
Clin Chem Lab Med. 2005;43(10):1096-100
16197304
Dement Geriatr Cogn Disord. 2007;23(5):321-6
17374950
FEBS Lett. 2006 May 29;580(13):2994-3005
16697371
N Engl J Med. 2006 Jun 29;354(26):2764-72
16807413
Stroke. 2005 Jun;36(6):1207-11
15879345
Ann Intern Med. 1999 Sep 7;131(5):352-5
10475888
Am J Clin Nutr. 2005 Sep;82(3):636-43
16155278
Am J Clin Nutr. 2003 Apr;77(4):826-33
12663279
Semin Vasc Med. 2005 May;5(2):98-109
16047263