title: Fragile privileges: autoimmunity in brain and eye.
abstract: Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease.
authors.affiliation: Max-Planck-Institute of Neurobiology, Martinsried, Germany. hwekerle@neuro.mpg.de
authors.forename: Hartmut
authors.initials: H
authors.lastname: Wekerle
authors.forename: De-ming
authors.initials: DM
authors.lastname: Sun
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000473:pathology; D005123:Eye / Q000276:immunology* / Q000473:pathology; D006801:Humans
references.citation: J Immunol. 1978 Mar;120(3):689-93
references.pmid: 632581
references.citation: Immunology. 1998 Sep;95(1):47-55
references.pmid: 9767456
references.citation: Nat Rev Mol Cell Biol. 2010 May;11(5):366-78
references.pmid: 20414258
references.citation: J Immunol. 2001 Jan 1;166(1):313-21
references.pmid: 11123307
references.citation: Nat Rev Immunol. 2008 Oct;8(10):753-63
references.pmid: 18787560
references.citation: Proc Natl Acad Sci U S A. 1990 Oct;87(20):7968-72
references.pmid: 1700423
references.citation: Nature. 2006 Jul 20;442(7100):299-302
references.pmid: 16855590
references.citation: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18625-30
references.pmid: 18000062
references.citation: Nature. 2009 Nov 5;462(7269):94-8
references.pmid: 19829296
references.citation: J Neuroimmunol. 1989 Jul;23(2):125-32
references.pmid: 2786005
references.citation: Eur J Immunol. 1992 Jan;22(1):165-73
references.pmid: 1530916
references.citation: J Immunol. 1977 Mar;118(3):809-14
references.pmid: 321682
references.citation: Am J Physiol. 1984 Jun;246(6 Pt 2):F835-44
references.pmid: 6742132
references.citation: Adv Immunol. 1977;25:1-54
references.pmid: 345773
references.citation: Proc Natl Acad Sci U S A. 1998 May 12;95(10):5779-84
references.pmid: 9576961
references.citation: Eur J Neurosci. 1996 Dec;8(12):2582-90
references.pmid: 8996807
references.citation: Cell Tissue Res. 2009 Jan;335(1):75-96
references.pmid: 18633647
references.citation: Cell Tissue Res. 2010 Jan;339(1):47-57
references.pmid: 19697064
references.citation: J Immunol. 1993 Nov 15;151(10):5162-71
references.pmid: 8228216
references.citation: Brain Res Brain Res Rev. 1999 Jul;30(1):77-105
references.pmid: 10407127
references.citation: Nat Neurosci. 2006 Jul;9(7):917-24
references.pmid: 16732273
references.citation: Immunology. 1990 Nov;71(3):383-9
references.pmid: 1702748
references.citation: Semin Immunopathol. 2008 Apr;30(2):165-77
references.pmid: 18305941
references.citation: Nat Med. 2003 Feb;9(2):206-12
references.pmid: 12514742
references.citation: J Exp Med. 1981 May 1;153(5):1058-67
references.pmid: 6788883
references.citation: Curr Opin Immunol. 1993 Jun;5(3):428-32
references.pmid: 8347303
references.citation: Springer Semin Immunopathol. 1999;21(2):95-111
references.pmid: 10457584
references.citation: J Exp Med. 1999 Nov 1;190(9):1215-26
references.pmid: 10544194
references.citation: J Immunol. 2003 Aug 1;171(3):1266-71
references.pmid: 12874214
references.citation: Nat Med. 1999 Jul;5(7):843-7
references.pmid: 10395334
references.citation: Eur J Immunol. 1982 Jun;12(6):480-4
references.pmid: 6981513
references.citation: Nat Med. 2009 Jun;15(6):626-32
references.pmid: 19483694
references.citation: Immunity. 2001 May;14(5):547-60
references.pmid: 11371357
references.citation: Eur J Immunol. 1981 Mar;11(3):195-9
references.pmid: 6165588
references.citation: J Exp Med. 2005 Jun 6;201(11):1805-14
references.pmid: 15939794
references.citation: J Exp Med. 2005 May 16;201(10):1615-25
references.pmid: 15883173