title: Progress toward novel treatments for chronic kidney disease.
abstract: Chronic kidney failure remains a major health problem worldwide. Although current treatment is focused on the renin-angiotensin system, it is essential that new treatments targeted toward novel pathophysiological mechanisms are developed if we are to make significant progress in this area. In this review, we have outlined several promising new areas while emphasizing that large, randomized, well-controlled clinical trials are essential to reach a meaningful conclusion about the efficacy and safety of novel treatment.
authors.affiliation: Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. shahsudhirv@uams.edu
authors.forename: Sudhir V
authors.initials: SV
authors.lastname: Shah
mesh_terms: D000577:Amides / Q000627:therapeutic use; D000925:Anticoagulants; D000959:Antihypertensive Agents; D001639:Bicarbonates / Q000627:therapeutic use; D002908:Chronic Disease; D004791:Enzyme Inhibitors; D005650:Fumarates / Q000627:therapeutic use; D006025:Glycosaminoglycans / Q000627:therapeutic use; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D007502:Iron Chelating Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000517:prevention & control; D008301:Maleimides / Q000627:therapeutic use; D010431:Pentoxifylline / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011728:Pyridones / Q000627:therapeutic use; D012084:Renin-Angiotensin System; D000092502:Renin Inhibitors
chemical_list: D000577:Amides; D000925:Anticoagulants; D000959:Antihypertensive Agents; D001639:Bicarbonates; D004791:Enzyme Inhibitors; D005650:Fumarates; D006025:Glycosaminoglycans; D007211:Indoles; D007502:Iron Chelating Agents; D008301:Maleimides; D010431:Pentoxifylline; D010726:Phosphodiesterase Inhibitors; D011493:Protein Kinase C; D011728:Pyridones; D000092502:Renin Inhibitors; C446481:aliskiren; C099154:ruboxistaurin; C007858:glucuronyl glucosamine glycan sulfate; C093844:pirfenidone