title: [Functional imaging of deep brain stimulation in idiopathic Parkinson's disease].
abstract: Functional brain imaging allows the effects of deep brain stimulation (DBS) on the living human brain to be investigated. In patients with advanced Parkinson's disease (PD), positron emission tomography (PET) studies were undertaken at rest as well as under motor, cognitive or behavioral activation. DBS leads to a reduction of abnormal PD-related network activity in the motor system, which partly correlates with the improvement of motor symptoms. The local increase of energy consumption within the direct target area suggests a predominant excitatory influence of the stimulation current on neuronal tissue. Remote effects of DBS of the subthalamic nucleus (STN) on frontal association cortices indicate an interference of stimulation energy with associative and limbic basal ganglia loops. Taken together, functional brain imaging provides very valuable data for advancement of the DBS technique in PD therapy.
authors.affiliation: Zentrum der Neurologie und Neurochirurgie, Klinik für Neurologie, Goethe-Universität, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland. hilker@med.uni-frankfurt.de
authors.forename: R
authors.initials: R
authors.lastname: Hilker
mesh_terms: D000339:Affect / Q000502:physiology; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D046690:Deep Brain Stimulation; D004298:Dopamine / Q000378:metabolism; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008032:Limbic System / Q000000981:diagnostic imaging / Q000503:physiopathology; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D009474:Neurons / Q000000981:diagnostic imaging / Q000502:physiology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods*; D020531:Subthalamic Nucleus / Q000000981:diagnostic imaging / Q000503:physiopathology; D014705:Verbal Behavior / Q000502:physiology
chemical_list: D019788:Fluorodeoxyglucose F18; D004298:Dopamine
references.citation: J Neuropathol Exp Neurol. 2001 Jan;60(1):15-24
references.pmid: 11202172
references.citation: Brain. 2004 Mar;127(Pt 3):602-15
references.pmid: 14736753
references.citation: Brain. 2002 Sep;125(Pt 9):1995-2004
references.pmid: 12183345
references.citation: Mov Disord. 2003 Jan;18(1):41-8
references.pmid: 12518299
references.citation: Neuroimage. 2005 Nov 15;28(3):598-606
references.pmid: 16081302
references.citation: Neurology. 2008 Sep 2;71(10):708-13
references.pmid: 18650492
references.citation: Mov Disord. 2006 Jun;21 Suppl 14:S305-27
references.pmid: 16810676
references.citation: Brain. 1996 Apr;119 ( Pt 2):585-91
references.pmid: 8800950
references.citation: Brain. 2007 Aug;130(Pt 8):2129-45
references.pmid: 17584773
references.citation: Ann Neurol. 2003 Oct;54(4):445-50
references.pmid: 14520655
references.citation: Hum Brain Mapp. 2009 Jan;30(1):112-21
references.pmid: 18041743
references.citation: Neurology. 2003 Sep 23;61(6):816-21
references.pmid: 14504327
references.citation: Brain. 2001 Aug;124(Pt 8):1601-9
references.pmid: 11459751
references.citation: Ann Neurol. 1997 Sep;42(3):283-91
references.pmid: 9307248
references.citation: Neurology. 2009 Nov 24;73(21):1746-51
references.pmid: 19933975
references.citation: Science. 2007 Nov 23;318(5854):1309-12
references.pmid: 17962524
references.citation: Ann Neurol. 2001 Feb;49(2):155-64
references.pmid: 11220735
references.citation: Brain. 2006 Oct;129(Pt 10):2667-78
references.pmid: 16844713
references.citation: Arch Neurol. 1999 Aug;56(8):997-1003
references.pmid: 10448806
references.citation: J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1217-21
references.pmid: 16107354
references.citation: Neurology. 2009 Jan 6;72(1):42-9
references.pmid: 19122029
references.citation: Brain. 2000 Jun;123 ( Pt 6):1142-54
references.pmid: 10825353
references.citation: Hum Brain Mapp. 2009 Dec;30(12):3901-9
references.pmid: 19479730
references.citation: Neuroimage. 2006 May 15;31(1):301-7
references.pmid: 16466936
references.citation: Neuroreport. 2003 Jul 1;14(9):1287-9
references.pmid: 12824777
references.citation: J Cereb Blood Flow Metab. 1994 Sep;14(5):783-801
references.pmid: 8063874
references.citation: Neuroimage. 2004 Feb;21(2):608-15
references.pmid: 14980563
references.citation: Neurology. 2006 Apr 25;66(8):1192-9
references.pmid: 16636237
references.citation: J Cereb Blood Flow Metab. 2004 Jan;24(1):7-16
references.pmid: 14688612
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10661-6
references.pmid: 17556546