title: A concise total synthesis of amphidinolide T2.
abstract: RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0% overall yield.
authors.affiliation: Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Huoming
authors.initials: H
authors.lastname: Li
authors.forename: Jinlong
authors.initials: J
authors.lastname: Wu
authors.forename: Jialu
authors.initials: J
authors.lastname: Luo
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Dai
mesh_terms: D002384:Catalysis; D006900:Hydroxylation; D007773:Lactates / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D008024:Ligands; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D007773:Lactates; D007783:Lactones; D008024:Ligands; D018942:Macrolides; C578435:amphidinolide T2; D000097442:Amphidinolides; C028444:methyl lactate