The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma.
The E-cadherin-catenin complex provides cell-cell adhesion. In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohistochemistry and compared to their presence in 219 colon carcinomas. The expression data were correlated to clinical information from the patients' records. There were statistically significant differences in protein expression between the rectal and the colon carcinomas regarding membranous beta-catenin, gamma-catenin, p120-catenin, and E-cadherin, as well as nuclear beta-catenin. In the rectal carcinomas, there was a significant inverse association between the expression of p120-catenin in cell membranes of the primary tumors and the occurrence of local recurrence, while membranous protein expression of beta-catenin was inversely related to distant metastases.
Aamodt
Rolf
R
Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Norway.
Bondi
Johan
J
Andersen
Solveig Norheim
SN
Bakka
Arne
A
Bukholm
Geir
G
Bukholm
Ida R K
IR
Am J Clin Pathol. 1999 Jan;111(1):29-37
9894451
J Cell Biol. 2003 Nov 10;163(3):547-57
14610057
J Cell Biol. 1991 Apr;113(1):173-85
2007622
Annu Rev Cell Dev Biol. 2003;19:207-35
14570569
J Cell Biol. 1985 Jan;100(1):327-32
3880756
Jpn J Cancer Res. 1994 Mar;85(3):266-73
8188525
Oncogene. 2004 Oct 18;23(48):7947-56
15489912
Nat Cell Biol. 2000 Feb;2(2):76-83
10655586
Anticancer Res. 1997 Mar-Apr;17(2B):1349-54
9137497
Cancer Res. 1994 Jul 1;54(13):3544-52
8012979
Eur J Cancer. 1999 Jan;35(1):60-5
10211089
Cancer Res. 1993 Jul 15;53(14):3241-5
8324734
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10069-74
17537911
Nat Cell Biol. 2000 Feb;2(2):84-9
10655587
Mol Cell Biol. 1994 Dec;14(12):8333-42
7526156
Nat Cell Biol. 2006 Dec;8(12):1398-406
17072303
Cancer Res. 1993 Apr 1;53(7):1690-5
8453643
Curr Opin Cell Biol. 1993 Oct;5(5):806-11
8240824
Science. 1991 Nov 29;254(5036):1359-61
1962194
J Cell Biol. 2003 Nov 10;163(3):525-34
14610055
Cell. 1991 Jul 12;66(1):107-19
2070412
Oncogene. 1992 Dec;7(12):2439-45
1334250
Int J Colorectal Dis. 2006 Apr;21(3):231-7
15937692
Differentiation. 2002 Dec;70(9-10):583-9
12492499
Histopathology. 2007 Mar;50(4):453-64
17448021
J Cell Biol. 1977 Nov;75(2 Pt 1):464-74
264120
Int J Cancer. 1996 Sep 27;68(1):14-20
8895533
Am J Pathol. 1989 Jul;135(1):101-10
2774055
J Cell Sci. 1994 Dec;107 ( Pt 12):3655-63
7706414
J Cell Biol. 1994 Jun;125(6):1327-40
8207061
Am J Pathol. 1993 Apr;142(4):981-6
7682766
Genes Dev. 2000 Jun 1;14(11):1319-31
10837025
Cancer Lett. 1998 Oct 23;132(1-2):193-201
10397474
J Cell Biol. 1994 Jun;125(6):1341-52
8207062
J Pathol. 1998 Jul;185(3):262-6
9771479
FEBS Lett. 2009 Feb 18;583(4):627-32
19166851
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
18093941
Genes Dev. 2000 Aug 1;14(15):1837-51
10921899
J Pathol. 1992 Nov;168(3):287-91
1469507
Cancer Res. 1994 Jan 1;54(1):291-6
8261454
APMIS. 2004 Jan;112(1):49-56
14961975
Proc Natl Acad Sci U S A. 1995 May 23;92(11):5067-71
7761449
J Surg Oncol. 2006 Feb 1;93(2):151-60
16425303
Mol Cell Biol Res Commun. 1999 Aug;2(2):77-85
10542129
Biochim Biophys Acta. 2008 Mar;1778(3):562-71
18206110
Mol Cell Biol. 1999 May;19(5):3614-23
10207085
Am J Pathol. 1994 Apr;144(4):667-74
8160768
Lab Invest. 1995 May;72(5):506-12
7745946
Int J Cancer. 2004 Oct 10;111(6):921-8
15300804
Am J Pathol. 1996 Jan;148(1):39-46
8546224
Virchows Arch. 2001 Dec;439(6):725-51
11787845
Nat Rev Cancer. 2009 Apr;9(4):265-73
19262571
Scand J Gastroenterol. 2000 Aug;35(8):839-46
10994623
Virchows Arch. 1994;424(4):375-81
8205352
Br J Cancer. 1999 Jun;80(7):1046-51
10362114
J Biol Chem. 1991 Mar 5;266(7):4514-20
1999432
EMBO J. 1989 Jun;8(6):1711-7
2788574
Hepatogastroenterology. 1999 Jan-Feb;46(25):232-5
10228798