title: A new isoflavone glycoside from the stem bark of Sophora japonica.
abstract: A new isoflavone glycoside, 6-methoxy-7-hydroxy-4'-O-beta-D-glucosyl isoflavone, glycitein-4'-O-beta-D-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory effects of all the isolated compounds on aldose reductase were evaluated in vitro. Among these compounds, daidzein (1), puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC(50) values of 3.2, 6.4, and 1.9 microM, respectively.
authors.affiliation: College of Pharmacy, Kangwon National University, Chuncheon, 200-701, Korea.
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Park
authors.forename: Soo Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Gi Beom
authors.initials: GB
authors.lastname: Kim
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Sim
authors.forename: Soon Sung
authors.initials: SS
authors.lastname: Lim
authors.forename: Myong Jo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Wanjoo
authors.initials: W
authors.lastname: Chun
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Kwon
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000201:enzymology; D024301:Plant Bark; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D006027:Glycosides; D007529:Isoflavones; D000449:Aldehyde Reductase