title: Study of an integrated non-motor symptoms questionnaire for Parkinson's disease.
abstract: BACKGROUND
  Although the validity of non-motor symptoms screening questionnaire (NMSQuest) for Parkinson's disease has been verified in several recent researches, the specificity of the questionnaire is still in doubt. This study aimed to compare the non-motor symptoms (NMS) in Parkinson's disease (PD) with a medically ill control group.
  
  
  METHODS
  In this study, the first comprehensive clinic-based NMS screening questionnaire for PD developed by the Parkinson's Disease Non-Motor Group (PDNMG) was used. Data from 90 PD patients and 270 sex-and age-matched control subjects, including stroke (n = 90), heart disease (n = 90) and diabetes (n = 90) were analyzed.
  
  
  RESULTS
  Compared with control group, NMS was more common in PD; on an average, most PD patients reported more than 12 non-motor items. There was a correlation of total NMS score in PD patients with Hoehn & Yahr Staging, but not with age, sex distribution, disease duration, or age at disease onset. Additionally, depression, constipation and impaired olfaction which occurred prior to the motor symptoms of PD were reported in this study.
  
  
  CONCLUSIONS
  NMS are more common in PD patients. There are some NMS that occurred at the preclinical stage of PD and might predict the onset of motor symptoms of PD patients.
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Zhi-ying
authors.initials: ZY
authors.lastname: Xiao
authors.forename: Jia-zhen
authors.initials: JZ
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D011795:Surveys and Questionnaires