High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies.
We performed a large case-control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin's lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.
Kang
Jun
J
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, South Korea.
Cho
Jeong Hyun
JH
Suh
Cheol Won
CW
Lee
Dae Ho
DH
Oh
Heung Bum
HB
Sohn
Yong Hak
YH
Chi
Hyun Sook
HS
Park
Chan Jeong
CJ
Jang
Sung Soo
SS
Lee
Kyoo Hyung
KH
Lee
Je-Hwan
JH
Lee
Jung Hee
JH
Lee
Sang Wook
SW
Chung
Young Hwa
YH
Kim
Tae Hyup
TH
Shin
Hai-Rim
HR
Huh
Jooryung
J
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000821:virology*; D016174:Hepacivirus / Q000472:pathogenicity; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology*; D006515:Hepatitis B virus / Q000472:pathogenicity; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology