title: Recurrence of Chlamydiasuis infection in pigs after short-term antimicrobial treatment.
abstract: The effect of short-term antimicrobial treatment on natural excretion of Chlamydia suis in rectal swabs and C. suis and Chlamydophila psittaci in nasal swabs was investigated in 47 clinically normal piglets by quantitative real-time PCR. Pigs were treated IM with 4 mg/kg enrofloxacin for 5 days (n = 22) or 2.5mg/kg enrofloxacin for 3 days followed by 100mg/mL tiamulin (n = 25). Antimicrobial treatment reduced the number of pigs positive for chlamydiae and the quantity of chlamydial DNA in positive swabs for a few days, but chlamydial excretion recurred in both groups. Short-term antimicrobial treatment at dosages recommended for treatment of other bacterial infections in pig herds was not effective in eliminating naturally occurring subclinical chlamydial infection in pigs.
authors.affiliation: Institute of Molecular Pathogenesis in the Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany. petra.reinhold@fli.bund.de
authors.forename: Petra
authors.initials: P
authors.lastname: Reinhold
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Liebler-Tenorio
authors.forename: Stephanie
authors.initials: S
authors.lastname: Sattler
authors.forename: Konrad
authors.initials: K
authors.lastname: Sachse
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D002691:Chlamydophila psittaci; D004224:Diterpenes / Q000627:therapeutic use; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012008:Recurrence; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D024841:Fluoroquinolones; D000077422:Enrofloxacin; C014224:tiamulin