Can we see epithelium tissue structure below the surface using an optical probe?
This paper answers the question of whether it is possible to detect changes below the surface in epithelium layered structures using a Stochastic Decomposition Method (SDM) that models the scattered light reflected from the layered structure over an area (2-D scan) illuminated by an optical sensor (fibre) emitting light at either one wavelength or with white light. Our technique correlates the differential changes in the reflected tissue texture with the morphological and physical changes that occur in the tissue occurring inside the structure. This work has great potential for detecting changes in mucosal structures and may lead to enhanced endoscopy when the disease is developing to the outside of the mucosal structure and hence becoming hidden during colonoscopy or endoscopic examination. Tests are performed on layered tissue phantoms, and the results obtained show great effectiveness of the model and method in picking up changes in the morphology of the layered tissue phantoms occurring below the surface. We also establish the robustness of the model to changes in viewing depth by testing it on phantoms viewed at different depths. We show that the model is robust to within a 4-mm-deep viewing range.
Cohen
Fernand S
FS
Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA, USA.
Taslidere
Ezgi
E
Murthy
Sreekant
S
D002278:Carcinoma in Situ / Q000175:diagnosis*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D042241:Early Diagnosis; D006801:Humans; D008027:Light; D019047:Phantoms, Imaging; D011230:Precancerous Conditions / Q000175:diagnosis*; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes
J Biomed Opt. 2007 Jul-Aug;12(4):044011
17867815
Phys Med Biol. 2005 Mar 21;50(6):1071-93
15798309
Photochem Photobiol. 2000 Jun;71(6):730-6
10857369
Lasers Surg Med. 1994;15(4):351-7
7885168
Curr Opin Gastroenterol. 2005 Jan;21(1):70-9
15687888
IEEE Trans Ultrason Ferroelectr Freq Control. 2008 Jan;55(1):50-63
18334313
Gut. 2003 Jun;52 Suppl 4:iv12-6
12746263
Br J Surg. 2007 Jan;94(1):6-16
17205497
Appl Opt. 2005 Apr 20;44(12):2288-99
15861834
Med Biol Eng Comput. 2009 Nov;47(11):1197-206
19820979
J Gastroenterol Hepatol. 2002 Feb;17 Suppl:S85-104
12000596
CA Cancer J Clin. 1985 Nov-Dec;35(6):322-44
3931866
World J Surg. 2000 Sep;24(9):1081-90
11036286
J Biomed Opt. 2008 Sep-Oct;13(5):054039
19021419
Appl Opt. 2006 Jul 1;45(19):4776-90
16799693
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:1956-9
17946925
Appl Opt. 1996 Sep 1;35(25):5211-9
21102960
Best Pract Res Clin Gastroenterol. 2005 Dec;19(6):941-61
16338651
IEEE Trans Ultrason Ferroelectr Freq Control. 2001 Mar;48(2):355-63
11370349
IEEE Trans Ultrason Ferroelectr Freq Control. 1997;44(2):460-72
18244144
Best Pract Res Clin Gastroenterol. 2002 Dec;16(6):999-1012
12473303
IEEE Trans Biomed Eng. 1996 Feb;43(2):113-22
8682522
Med Biol Eng Comput. 2010 May;48(5):415-22
20107915
J Opt Soc Am A Opt Image Sci Vis. 2007 Apr;24(4):1011-25
17361287
Gastroenterol Clin North Am. 2006 Sep;35(3):605-19
16952743
J Biomed Opt. 2003 Jul;8(3):484-94
12880355
J Fam Pract. 1992 Aug;35(2):194-200
1645113
Dig Dis Sci. 2007 Jun;52(6):1387-93
17415641
Gastroenterology. 2004 Sep;127(3):706-13
15362025
World J Surg. 2000 Sep;24(9):1022-8
11036277
Best Pract Res Clin Gastroenterol. 2006 Feb;20(1):41-57
16473800
Int J Oncol. 2004 Jan;24(1):59-63
14654941
World J Surg. 1987 Dec;11(6):804-9
3433796
Hum Pathol. 1991 Jan;22(1):70-4
1985081