Genetic variants in the renin-angiotensin system and blood pressure reactions to the cold pressor test.
OBJECTIVE
The purpose of this study was to examine the association between genetic variants in the renin-angiotensin system and blood pressure (BP) responses to the cold pressor test (CPT).


METHODS
The CPT was conducted among 1998 Han Chinese participants. BP measurements were obtained before and after the CPT using a standard sphygmomanometer according to a standard protocol. The association between SNP genotypes and BP responses to the CPT was assessed using a mixed linear model.


RESULTS
Of 68 SNPs genotyped in six renin-angiotensin system genes, two were strongly associated with DBP responses to CPT (P ≤ 0.001; false discovery rate q value < 0.05): rs2006765 and rs943580 in the angiotensinogen (AGT) gene. Compared to C allele carriers of rs2006765, the TT homozygotes had a significantly decreased DBP response to the CPT. For participants with the TT genotype, percentage DBP responses were 5.68% (4.25-7.10%), compared to corresponding responses of 9.17% (8.66-9.68%) among participants with the CC+CT genotype. In addition, SNP rs4681443 of the angiotensin type 1 receptor (AGTR1) gene was significantly associated with percentage SBP responses to CPT (P ≤ 0.001; q-value <0.05).


CONCLUSIONS
Briefly, our study identified variants in the AGT and AGTR1 genes that may influence BP responses to CPT in the Han Chinese population. These results show that genetic variants in the renin-angiotensin system play an important role in BP responses to CPT and, therefore, in predicting future hypertension.
Wang
Laiyuan
L
Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hou
Liping
L
Li
Hongfan
H
Chen
Jing
J
Kelly
Tanika N
TN
Jaquish
Cashell E
CE
Rao
Dabeeru C
DC
Hixson
James E
JE
Hu
Dongsheng
D
Chen
Chung-Shiuan
CS
Gu
Charles
C
Chen
Shufeng
S
Lu
Xiangfeng
X
Whelton
Paul K
PK
He
Jiang
J
Lu
Fanghong
F
Huang
Jianfeng
J
Liu
De-Pei
DP
Gu
Dongfeng
D
D000328:Adult; D001794:Blood Pressure; D003080:Cold Temperature; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012084:Renin-Angiotensin System / Q000235:genetics*
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