title: Surgical resection in combination with lung volume reduction surgery for stage I non-small cell lung cancer.
abstract: Surgical resection remains the favored option of treatment for stage I lung cancer patients. Co-existing obstructive lung disease can reduce lung function and increase the risk of surgery. Severe emphysema may preclude resection of lung cancer due to concerns about low values of postoperative lung function. However, many patients will experience stable or improved lung function simply by resecting hyper-expanded and relatively functionless lung. This so-called "lung volume reduction effect" may occur after standard resection or after rare instances of formal lung volume reduction surgery concurrent with pulmonary resection of the tumor. This review explores these possibilities and informs the readers of pioneering work in this area.
authors.affiliation: Division of Cardiothoracic Surgery, Barnes-Jewish Hospital, Washington University School of Medicine, Saint Louis, Missouri, USA.
authors.forename: Wael N
authors.initials: WN
authors.lastname: Yacoub
authors.forename: Bryan F
authors.initials: BF
authors.lastname: Meyers
mesh_terms: D000465:Algorithms; D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D005541:Forced Expiratory Volume; D006305:Health Status Indicators; D006801:Humans; D008168:Lung / Q000473:pathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000601:surgery*; D011013:Pneumonectomy / Q000295:instrumentation / Q000379:methods; D011300:Preoperative Care; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology / Q000601:surgery*; D013906:Thoracoscopy