title: Percutaneous osteoplasty with a bone marrow nail for fractures of long bones: experimental study.
abstract: OBJECTIVE
  To develop percutaneous osteoplasty with the use of a bone marrow nail for fixation of long-bone fractures, and to evaluate its feasibility and safety in vivo and in vitro.
  
  
  METHODS
  Six long bones in three healthy swine were used in the in vivo study. Acrylic cement was injected through an 11-gauge bone biopsy needle and a catheter into a covered metallic stent placed within the long bone, creating a bone marrow nail. In the in vitro study, we determined the bending, tug, and compression strengths of the acrylic cement nails 9 cm long and 8 mm in diameter (N = 10). The bending strength of the artificially fractured bones (N = 6) restored with the bone marrow nail and cement augmentation was then compared with that of normal long bones (N = 6).
  
  
  RESULTS
  Percutaneous osteoplasty with a bone marrow nail was successfully achieved within 1 hour for all swine. After osteoplasty, all swine regained the ability to run until they were euthanized. Blood tests and pathologic findings showed no adverse effects. The mean bending, tug, and compression strengths of the nail were 91.4 N/mm(2) (range, 75.0-114.1 N/mm(2)), 20.9 N/mm(2) (range, 6.6-30.4 N/mm(2)), and 103.0 N/mm(2) (range, 96.3-110.0 N/mm(2)), respectively. The bending strength ratio of artificially fractured bones restored with bone marrow nail and cement augmentation to normal long bone was 0.32.
  
  
  CONCLUSIONS
  Percutaneous osteoplasty with use of a bone marrow nail and cement augmentation appears to have potential in treating fractures of non-weight-bearing long bones.
authors.affiliation: Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayamashi, Wakayama 641-8510, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Nakata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawai
authors.forename: Morio
authors.initials: M
authors.lastname: Sato
authors.forename: Guang
authors.initials: G
authors.lastname: Cao
authors.forename: Shinya
authors.initials: S
authors.lastname: Sahara
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Tanihata
authors.forename: Isao
authors.initials: I
authors.lastname: Takasaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Minamiguchi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakai
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001706:Biopsy / Q000295:instrumentation; D001843:Bone Cements / Q000494:pharmacology*; D001853:Bone Marrow / Q000601:surgery*; D001858:Bone Nails; D002404:Catheterization; D057785:Catheters; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005593:Fracture Fixation, Internal / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D017102:Fracture Healing; D006810:Humeral Fractures / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008422:Materials Testing; D020366:Methylmethacrylate / Q000494:pharmacology*; D009339:Needles; D011474:Prosthesis Design; D011859:Radiography; D015607:Stents; D013314:Stress, Mechanical; D013552:Swine; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors
chemical_list: D001843:Bone Cements; D020366:Methylmethacrylate