title: Behavior, brain, and genome in genomic disorders: finding the correspondences.
abstract: OBJECTIVE
  Within the last decade or so, there has been an acceleration of research attempting to connect specific genetic lesions to the patterns of brain structure and activation. This article comments on observations that have been made based on these recent data and discusses their importance for the field of investigations into developmental disorders.
  
  
  METHODS
  In making these observations, the authors focus on one specific genomic lesion, the well-studied, yet still incompletely understood, 22q11.2 deletion syndrome.
  
  
  RESULTS
  The authors demonstrate the degree of variability in the phenotype that occurs at both the brain and behavioral levels of genomic disorders and describe how this variability is, on close inspection, represented at the genomic level.
  
  
  CONCLUSIONS
  The authors emphasize the importance of combining genetic/genomic analyses and neuroimaging for research and for future clinical diagnostic purposes and for the purposes of developing individualized, patient-tailored treatment and remediation approaches.
authors.affiliation: Yale University, New Haven, CT, USA. Elena.Grigorenko@Yale.Edu
authors.forename: Elena L
authors.initials: EL
authors.lastname: Grigorenko
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Urban
authors.forename: Einar
authors.initials: E
authors.lastname: Mencl
mesh_terms: D001921:Brain / Q000503:physiopathology*; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D002658:Developmental Disabilities / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D004062:DiGeorge Syndrome / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D010641:Phenotype
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