[Tumor-specific expression of PBOV1, a new gene in evolution].
We identified mRNA of the newly discovered gene PBOV1 in a multitude of samples from tumors of the brain, lung, liver, gallbladder, colon, small intestine, mammary gland, uterus, ovary, ureter, adrenals, parotid, thymus and spleen. However, out of 29 intact adult and 8 fetal tissues, only pancreas was characterized by weak expression of the gene. Our results demonstrated that the PBOV1 gene expression is tumor-specific and has a potential as tumor marker. It is worth mentioning that we had predicted that property on the basis of available evolutionary data.
Krukovskaia
L L
LL
Samusik
N D
ND
Shilov
E S
ES
Polev
D E
DE
Kozlov
A P
AP
D000328:Adult; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D055028:Comparative Genomic Hybridization; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005833:Genital Neoplasms, Female / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D013736:Testicular Neoplasms / Q000378:metabolism
D009363:Neoplasm Proteins; C420220:PBOV1 protein, human; D012333:RNA, Messenger