Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients.
BACKGROUND
Patients with late onset hypogonadism (LOH) also suffered from lower urinary tract symptoms (LUTS) and LOH symptoms. The objects of this study are to evaluate the efficacy of testosterone replace therapy (TRT) by testosterone ointment (Glowmin: GL) for LUTS in LOH patients.


METHODS
The Aging Male Symptom (AMS) scale, Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36), International Index of Erectile Function (IIEF-5) and the International Prostate Symptom Score (IPSS) were obtained from patients with LOH. A total of 41 patients with LOH have been treated with TRT using 6 mg/day of GL for 3 months. Serum free testosterone levels (FT) and these four scores were compared before and after TRT.


RESULTS
Serum FT levels and the scores for the four parameters of AMS, six of eight domains in SF-36, IIEF-5 and total IPSS improved significantly after 3 months TRT. In addition, all IPSS domains also improved significantly, and voiding disturbance seems to have improved more than storage disturbance (P = 0.0280 vs. 0.0483).


CONCLUSIONS
TRT by administration of GL is considered to be effective in the improvement of not only ED and LOH symptoms, but also LUTS (especially voiding disturbance) of patients with LOH.
Amano
Toshiyasu
T
Department of Urology, Nagano Red Cross Hospital, Nagano, Japan. amanot@nagano-med.jrc.or.jp
Imao
Tetsuya
T
Takemae
Katsurou
K
Iwamoto
Teruaki
T
Nakanome
Mariko
M
D000328:Adult; D017668:Age of Onset; D000368:Aged; D054796:Drug Dosage Calculations; D005837:Genitalia, Male / Q000187:drug effects* / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage; D010410:Penile Erection / Q000187:drug effects*; D010865:Pilot Projects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D018434:Sickness Impact Profile; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood; D016896:Treatment Outcome
D009824:Ointments; D013739:Testosterone