title: Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.
abstract: A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines, a series of substituted aryl ureas were achieved in high yields. Acetoacetanilide substrates can be considered as masked reagents that liberate reactive isocyanates in situ.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Shaoxia
authors.initials: S
authors.lastname: Lin
authors.forename: Hongqian
authors.initials: H
authors.lastname: Ding
authors.forename: Fushun
authors.initials: F
authors.lastname: Liang
authors.forename: Baozhong
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D017953:Isocyanates / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism; D014508:Urea / Q000138:chemical synthesis*
chemical_list: D000083:Acetanilides; D017953:Isocyanates; D014508:Urea; D011392:Proline; C056965:acetoacetanilide