title: Topographical differences in distribution and responsiveness of trigeminal sensitivity within the human nasal mucosa.
abstract: The study was designed to provide a topographical map of the sensitivity of the human nasal respiratory epithelium towards trigeminal chemosensory stimuli. As an electrophysiological measure of intranasal trigeminal activation at the level of the epithelium, we used the so-called negative mucosa potential (NMP), a measure that represents the sum of generator potentials of trigeminal receptor neurons after chemical stimulation. Sixty subjects participated (30 men and 30 women; mean age 23.5 years). Measurements were made in response to stimulation with menthol, CO(2), ethanol, and cinnamaldehyde, which are known to activate trigeminal receptors to various degrees. Recordings of the NMP were made from five intranasal sites: the anterior septum, the posterior septum, the tip of the middle turbinate, the tip of the lower turbinate, and the lateral side wall of the posterior nasal cavity. The recording electrode was positioned under endoscopic control. The largest NMP amplitudes were recorded at the anterior septum in response to stimulation with CO(2). Comparing all recording sites, significant differences were observed between responses at the posterior septum and the lateral side wall of the posterior nasal cavity in response to stimulation by ethanol, menthol, and CO(2). These findings suggest that the presence of topographical and chemosensory differences in the responsiveness of the nasal mucosa to irritants.
authors.affiliation: Smell & Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School "Technische Universität Dresden", Dresden, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Meusel
authors.forename: Simona
authors.initials: S
authors.lastname: Negoias
authors.forename: Mandy
authors.initials: M
authors.lastname: Scheibe
authors.forename: Thomas
authors.initials: T
authors.lastname: Hummel
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D002245:Carbon Dioxide / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D000432:Methanol / Q000494:pharmacology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D013223:Statistics as Topic; D013268:Stimulation, Chemical; D014276:Trigeminal Nerve / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
chemical_list: D002245:Carbon Dioxide; D000431:Ethanol; D000432:Methanol
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