title: A diverse development of 5-HT1A receptor binding is relevant to behavioral differences observed in adult mice of two genetically closely related inbred strains.
abstract: Only few genetic loci were supposed to be crucial for strong behavioral differences, especially in locomotion and aggression, in two closely related mice inbred strains: AB/Halle (ABH) and AB/Gatersleben (ABG). Previously we reported remarkable strain differences in 5-HT1A receptor binding in adult mice. In the present study, we were interested if the strain-specific 5-HT1A receptor binding pattern is already present very early in ontogeny which could indirectly hint at a gene that is differentially regulated in these 2 mouse strains. Since the 5-HT1A receptor is involved in the regulation of locomotion and aggression, one genetic determinate for the behavioral differences in ABH and ABG mice would have been found. Therefore, we measured [³H]8-OH-DPAT specific binding at postnatal day (PND) 1 and 21 (weanlings) using in vitro autoradiography. 5-HT1A receptor binding was not significantly different at PND 1 between strains. However, in weanlings the same 5-HT1A receptor binding pattern was observed as in adults, i.e. ABH mice display a higher forebrain 5-HT1A receptor binding compared to ABG mice. So the strain-specific forebrain 5-HT1A receptor binding pattern develops during the first 3 postnatal weeks and genetically driven mechanisms seem to be crucial. However, early environmental influences, e.g. differences in maternal care, can't be excluded.
authors.affiliation: Experimentelle Psychiatrie, Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum der TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Lydia.Guenther@uniklinikum-dresden.de
authors.forename: Lydia
authors.initials: L
authors.lastname: Günther
authors.forename: Markus
authors.initials: M
authors.lastname: Donix
authors.forename: Monika
authors.initials: M
authors.lastname: Jähkel
authors.forename: Jochen
authors.initials: J
authors.lastname: Oehler
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000374:Aggression / Q000502:physiology; D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000502:physiology; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013045:Species Specificity
chemical_list: D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin