MicroRNA expression and its implication for the diagnosis and therapeutic strategies of gastric cancer.
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicated that miRNAs are aberrantly expressed in a variety of human cancers and crucial to tumorigenesis. We herein provide a brief review of miRNA biogenesis, function, deregulation and their possible role as oncogenes or tumor suppressors in the pathogenesis of gastric cancer. The role of miRNAs in the carcinogenic effect of Helicobacter pylori infection was also discussed. Finally, we comment on the potential role of miRNAs in improving the current management of gastric cancer.
Wang
Jianbo
J
Department of Radiation Oncology, Qilu Hospital of Shandong University, West Wenhua Rd 107, 250012 Jinan, China.
Wang
Qingwei
Q
Liu
Hong
H
Hu
Bo
B
Zhou
Wei
W
Cheng
Yufeng
Y
D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D016481:Helicobacter Infections / Q000235:genetics / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000382:microbiology / Q000628:therapy
D035683:MicroRNAs