Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.
OBJECTIVE
To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS).


METHODS
DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every 6 months in DPPOS for a median 10.0-year follow-up.


RESULTS
Controlled for factors associated with diabetes risk, continuous antidepressant use compared with no use was associated with diabetes risk in the placebo (adjusted hazard ratio 2.34 [95% CI 1.32-4.15]) and lifestyle (2.48 [1.45-4.22]) arms, but not in the metformin arm (0.55 [0.25-1.19]).


CONCLUSIONS
Continuous antidepressant use was significantly associated with diabetes risk in the placebo and lifestyle arms. Measured confounders and mediators did not account for this association, which could represent a drug effect or reflect differences not assessed in this study between antidepressant users and nonusers.
Rubin
Richard R
RR
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. dppmail@biostat.bsc.gwu.edu
Ma
Yong
Y
Peyrot
Mark
M
Marrero
David G
DG
Price
David W
DW
Barrett-Connor
Elizabeth
E
Knowler
William C
WC
D000928:Antidepressive Agents / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans
D000928:Antidepressive Agents
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