title: Effect of atorvastatin on chronic periodontitis: a randomized pilot study.
abstract: OBJECTIVE
  We studied the effect of atorvastatin (ATV) treatment on bone loss prevention in subjects with chronic periodontitis.
  
  
  METHODS
  In this controlled double-blind study, 38 subjects with chronic periodontitis were randomized into two groups, paired by age to receive ATV (20 mg) or placebo daily for 3 months. Periodontal mechanical treatment was carried out in both groups at baseline. Clinical and radiographic parameters and bone turnover markers were assessed at baseline and at 3 months.
  
  
  RESULTS
  Periodontal disease conditions improved in both groups. After comparing the figures of change, significant improvements were observed in cholesterol levels (Δ=-58.5 ± 37.6 versusΔ=5.4 ± 41.2 mg/dl, p<0.0002), low-density lipoprotein levels (Δ=-48.1 ± 31.7 versusΔ=1.9 ± 42.8 mg/dl, p<0.002), dental mobility (Δ=-0.17 ± 0.11 versusΔ=-0.06 ± 0.11%, p<0.04), and the distance from the crestal alveolar bone to the cemento-enamel junction (Δ=-0.75 ± 0.7 versusΔ=0.09 ± 0.4 mm, p<0.0006) in the ATV group.
  
  
  CONCLUSIONS
  The results suggest that ATV might have beneficial effects on bone alveolar loss and tooth mobility in subjects with periodontal disease.
authors.affiliation: Department of Medical Sciences, University of Guanajuato, Leon, Mexico. eugeniafajardo@yahoo.com
authors.forename: Martha Eugenia
authors.initials: ME
authors.lastname: Fajardo
authors.forename: Miriam Lucía
authors.initials: ML
authors.lastname: Rocha
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Sánchez-Marin
authors.forename: Emanuel Jaime
authors.initials: EJ
authors.lastname: Espinosa-Chávez
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000517:prevention & control*; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000069059:Atorvastatin; D055113:Chronic Periodontitis / Q000188:drug therapy*; D003773:Dental Plaque / Q000517:prevention & control; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D005889:Gingival Recession / Q000517:prevention & control; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011758:Pyrroles / Q000627:therapeutic use*; D019252:Radiography, Dental, Digital; D018709:Statistics, Nonparametric; D014086:Tooth Mobility / Q000517:prevention & control
chemical_list: D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D008055:Lipids; D011758:Pyrroles; D000069059:Atorvastatin