Upper-body morbidity following breast cancer treatment is common, may persist longer-term and adversely influences quality of life.
BACKGROUND
Impairments in upper-body function (UBF) are common following breast cancer. However, the relationship between arm morbidity and quality of life (QoL) remains unclear. This investigation uses longitudinal data to describe UBF in a population-based sample of women with breast cancer and examines its relationship with QoL.


METHODS
Australian women (n=287) with unilateral breast cancer were assessed at three-monthly intervals, from six- to 18-months post-surgery (PS). Strength, endurance and flexibility were used to assess objective UBF, while the Disability of the Arm, Shoulder and Hand questionnaire and the Functional Assessment of Cancer Therapy-Breast questionnaire were used to assess self-reported UBF and QoL, respectively.


RESULTS
Although mean UBF improved over time, up to 41% of women revealed declines in UBF between six- and 18-months PS. Older age, lower socioeconomic position, treatment on the dominant side, mastectomy, more extensive lymph node removal and having lymphoedema each increased odds of declines in UBF by at least two-fold (p<0.05). Lower baseline and declines in perceived UBF between six- and 18-months PS were each associated with poorer QoL at 18-months PS (p<0.05).


CONCLUSIONS
Significant upper-body morbidity is experienced by many following breast cancer treatment, persisting longer term, and adversely influencing the QoL of breast cancer survivors.
Hayes
Sandra C
SC
School of Public Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Queensland, 4059, Australia. sc.hayes@qut.edu.au
Rye
Sheree
S
Battistutta
Diana
D
DiSipio
Tracey
T
Newman
Beth
B
D001315:Australia; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000209:etiology / Q000523:psychology; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D011594:Psychometrics; D011788:Quality of Life; D016059:Range of Motion, Articular; D020127:Recovery of Function; D015203:Reproducibility of Results; D012647:Self-Assessment; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D034941:Upper Extremity
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