title: Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for sustained drug delivery.
abstract: In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery.
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India. subheetjain@rediffmail.com
authors.forename: Subheet
authors.initials: S
authors.lastname: Jain
authors.forename: Amanpreet
authors.initials: A
authors.lastname: Kaur
authors.forename: Richa
authors.initials: R
authors.lastname: Puri
authors.forename: Puneet
authors.initials: P
authors.lastname: Utreja
authors.forename: Anubhuti
authors.initials: A
authors.lastname: Jain
authors.forename: Mahesh
authors.initials: M
authors.lastname: Bhide
authors.forename: Rakesh
authors.initials: R
authors.lastname: Ratnam
authors.forename: Vinay
authors.initials: V
authors.lastname: Singh
authors.forename: A S
authors.initials: AS
authors.lastname: Patil
authors.forename: N
authors.initials: N
authors.lastname: Jayaraman
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kaushik
authors.forename: Subodh
authors.initials: S
authors.lastname: Yadav
authors.forename: K L
authors.initials: KL
authors.lastname: Khanduja
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage; D008297:Male; D051379:Mice; D013055:Spectrophotometry, Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D050091:Dendrimers; D004337:Drug Carriers; D007660:Ketoprofen