title: Intracranial volume and whole brain volume in infants with unicoronal craniosynostosis.
abstract: OBJECTIVE
  Craniosynostosis has been hypothesized to result in alterations of the brain and cerebral blood flow due to reduced intracranial volume, potentially leading to cognitive deficits. In this study we test the hypothesis that intracranial volume and whole brain volume in infants with unilateral coronal synostosis differs from those in unaffected infants.
  
  
  METHODS
  Our study sample consists of magnetic resonance images acquired from 7- to 72-week-old infants with right unilateral coronal synostosis prior to surgery (n  =  10) and age-matched unaffected infants (n  =  10). We used Analyze 9.0 software to collect three cranial volume measurements. We used nonparametric tests to determine whether the three measures differ between the two groups. Correlations were calculated between age and the three volume measures in each group to determine whether the growth trajectory of the measurements differ between children with right unicoronal synostosis and unaffected infants.
  
  
  RESULTS
  Our results show that the three volume measurements are not reduced in infants with right unicoronal synostosis relative to unaffected children. Correlation analyses between age and various volume measures show similar correlations in infants with right unicoronal synostosis compared with unaffected children.
  
  
  CONCLUSIONS
  Our results show that the relationship between brain size and intracranial size in infants with right unicoronal synostosis is similar to that in unaffected children, suggesting that reduced intracranial volume is not responsible for alterations of the brain in craniosynostosis.
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Hill
authors.forename: S
authors.initials: S
authors.lastname: Vaddi
authors.forename: Amanda
authors.initials: A
authors.lastname: Moffitt
authors.forename: A A
authors.initials: AA
authors.lastname: Kane
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Marsh
authors.forename: Jayesh
authors.initials: J
authors.lastname: Panchal
authors.forename: Joan T
authors.initials: JT
authors.lastname: Richtsmeier
authors.forename: Kristina
authors.initials: K
authors.lastname: Aldridge
mesh_terms: D000367:Age Factors; D001921:Brain / Q000254:growth & development / Q000473:pathology*; D016022:Case-Control Studies; D003393:Cranial Sutures / Q000002:abnormalities; D003398:Craniosynostoses / Q000473:pathology* / Q000503:physiopathology; D005624:Frontal Bone / Q000002:abnormalities*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D009929:Organ Size; D010294:Parietal Bone / Q000002:abnormalities*
references.citation: J Anat. 2005 Apr;206(4):373-85
references.pmid: 15817105
references.citation: Childs Nerv Syst. 2000 Nov;16(10-11):645-58
references.pmid: 11151714
references.citation: Plast Reconstr Surg. 1998 Sep;102(3):619-28; discussion 629-32
references.pmid: 9727425
references.citation: Neurosurgery. 1981 Oct;9(4):366-72
references.pmid: 7301080
references.citation: AJNR Am J Neuroradiol. 2003 Jan;24(1):45-51
references.pmid: 12533326
references.citation: J Neurosurg. 1982 Sep;57(3):370-7
references.pmid: 7097333
references.citation: Neurosurg Clin N Am. 1991 Jul;2(3):569-85
references.pmid: 1821305
references.citation: Childs Nerv Syst. 2007 Mar;23(3):269-81
references.pmid: 17186250
references.citation: Childs Nerv Syst. 1998 Jun;14(6):247-55
references.pmid: 9694336
references.citation: Childs Nerv Syst. 2005 Oct;21(10):861-70
references.pmid: 15791470
references.citation: Plast Reconstr Surg. 2007 May;119(6):1874-1881
references.pmid: 17440368
references.citation: Plast Reconstr Surg. 1987 Jan;79(1):24-32
references.pmid: 3797514
references.citation: Childs Nerv Syst. 2005 Oct;21(10):913-21
references.pmid: 15871027
references.citation: Br J Plast Surg. 1992 Jul;45(5):394-7
references.pmid: 1638296
references.citation: Front Oral Biol. 2008;12:79-90
references.pmid: 18391496
references.citation: Semin Pediatr Neurol. 2004 Dec;11(4):262-7
references.pmid: 15828710
references.citation: J Neurosurg. 2005 Aug;103(2 Suppl):137-41
references.pmid: 16370279
references.citation: Surg Neurol. 1984 Sep;22(3):249-52
references.pmid: 6463834
references.citation: Plast Reconstr Surg. 1992 Sep;90(3):377-81
references.pmid: 1513883
references.citation: J Anat. 2002 Jul;201(1):31-9
references.pmid: 12171474
references.citation: Cleft Palate Craniofac J. 1999 Jul;36(4):314-21
references.pmid: 10426597
references.citation: J Exp Zool B Mol Dev Evol. 2006 Jul 15;306(4):360-78
references.pmid: 16526048
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2005 Aug;285(2):690-8
references.pmid: 15977220
references.citation: Plast Reconstr Surg. 2004 Feb;113(2):557-65
references.pmid: 14758218
references.citation: Pediatr Neurosurg. 2002 Dec;37(6):310-20
references.pmid: 12422046
references.citation: J Neurosurg. 1999 Oct;91(4):617-25
references.pmid: 10507384
references.citation: J Craniofac Surg. 1998 May;9(3):234-9
references.pmid: 9693554
references.citation: J Pediatr Psychol. 2004 Dec;29(8):651-68
references.pmid: 15491988
references.citation: Cleft Palate Craniofac J. 1998 May;35(3):194-6
references.pmid: 9603551
references.citation: J Neurosurg. 2007 Aug;107(2 Suppl):103-10
references.pmid: 18459881
references.citation: J Craniofac Surg. 1990 Jan;1(1):1-3
references.pmid: 2088558
references.citation: Surg Neurol. 2007;68 Suppl 2:S18-21; discussion S21
references.pmid: 18037036
references.citation: Pediatr Neurosurg. 1995;22(5):235-40
references.pmid: 7547454