title: A child with serious Chikungunya virus (CHIKV) infection requiring intensive care, after an outbreak.
abstract: A 5 1/2-yr-old boy presented with high grade fever for 4 days, and cervical adenitis, body ache, arthralgia, followed by sudden onset of breathlessness. He had clinical, electrocardiographic and echo evidence of myocarditis and congestive cardiac failure. An enzyme-linked immunosorbent assay (MAC-IgM ELISA) with serum collected 5 days after disease onset showed IgM antibodies to CHIKV. He was managed conservatively and started showing symptomatic improvement by 3 days. At discharge, a repeat Echocardiogram (a week later) showed normal left ventricular (LV) function with mild Mitral regurgitation. On follow up, after 2 months, child remains asymptomatic. Other common aetiological agents were screened for and found negative. This may indicate a probable cardiac tropism for the virus.
authors.affiliation: Department of Pediatrics, Govt. TD Medical College, Alappuzha, Kerala, 688005, India. rpmpgi@gmail.com
authors.forename: P Ramesh
authors.initials: PR
authors.lastname: Menon
authors.forename: Krishnan
authors.initials: K
authors.lastname: C
authors.forename: Jayaram
authors.initials: J
authors.lastname: Sankar
authors.forename: K M
authors.initials: KM
authors.lastname: Gopinathan
authors.forename: Girija
authors.initials: G
authors.lastname: Mohan
mesh_terms: D018354:Alphavirus Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D065632:Chikungunya Fever; D002675:Child, Preschool; D004196:Disease Outbreaks; D006333:Heart Failure / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D056189:Viral Tropism
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