[Autoantibodies to glutamate, GABA, dopamine and serotonin in the dynamics of development of chronic brain epileptization in mice C578l/6].
In experiments on mice C57Bl/6 was studied the possibility of production of glutamate, GABA, dopamine and serotonin autoantibodies in the dynamics of development of chronic brain epileptization--pharmacological kindling, induced by daily administration of pentylenetetrazol in subconvulsive dose (30 mg/kg) during 24 days. 14 days after the start of the kindling autoantibodies to glutamate was detected in all experimental animals, to CABA--in 60% of mice, to serotonine--in 70%, and to dopamine--in 90%. After 24 days--the number of animals with autoantibodies to glutamate and dopamine was decreased, to serotonin--increased, and to GABA--was not altered. It was shown the relationship between detection neurotransmitters autoantibodies and severity of the convulsive reaction.
Vetrilé
L A
LA
Kuznetsova
L V
LV
Klishina
N Iu
NIu
Karpova
M N
MN
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004298:Dopamine / Q000276:immunology*; D004827:Epilepsy / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012701:Serotonin / Q000276:immunology*; D005680:gamma-Aminobutyric Acid / Q000276:immunology*
D001323:Autoantibodies; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D004298:Dopamine