New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention.
Bacterial translocation from the gastrointestinal tract is an important pathway initiating late-onset sepsis and necrotizing enterocolitis in very low-birth-weight infants. The emerging intestinal microbiota, nascent intestinal epithelia, naive immunity, and suboptimal nutrition (lack of breast milk) have roles in facilitating bacterial translocation. Feeding lactoferrin, probiotics, or prebiotics has presented exciting possibilities to prevent bacterial translocation in preterm infants, and clinical trials will identify the most safe and efficacious prevention and treatment strategies.
Sherman
Michael P
MP
University of Missouri, Department of Child Health, Children's Hospital, 404 Keene Street, Neonatology Suite 206, Columbia, MO 65201, USA. ShermanMP@health.missouri.edu
D018988:Bacterial Translocation; D020345:Enterocolitis, Necrotizing / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000382:microbiology*; D007422:Intestines / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use*
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