title: Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives.
abstract: A series of new 2-substituted [4-(1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one derivatives 7a-h to 9a-h were designed and synthesized from methyl (4-oxo-3,4-dihydrophthalazin-1-yl)acetate (4), which in was turn prepared from phthalic anhydride. The structure of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. Several of these compounds showed antimicrobial activity.
authors.affiliation: Advinus Therapeutics Pvt. Ltd., 21 & 22, Peenya II phase, Bangalore, 560 058 Karnataka, India.
authors.forename: Ajjanna M
authors.initials: AM
authors.lastname: Sridhara
authors.forename: Kallam R Venugopala
authors.initials: KR
authors.lastname: Reddy
authors.forename: Jathi
authors.initials: J
authors.lastname: Keshavayya
authors.forename: Palusa Sanath Kumar
authors.initials: PS
authors.lastname: Goud
authors.forename: Bankavadi C
authors.initials: BC
authors.lastname: Somashekar
authors.forename: Prosenjit
authors.initials: P
authors.lastname: Bose
authors.forename: Sanenahalli K
authors.initials: SK
authors.lastname: Peethambar
authors.forename: Satish Kumar
authors.initials: SK
authors.lastname: Gaddam
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000890:Anti-Infective Agents; D010793:Phthalazines