Hydoroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus.
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to possess significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 micronM, respectively.
Ryoo
In-Ja
IJ
Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Yun
Bong-Sik
BS
Lee
In-Kyoung
IK
Kim
Young-Hee
YH
Lee
Ik-Soo
IS
Ahn
Jong-Seok
JS
Bae
KiHwan
K
Yoo
Ick-Dong
ID
D031584:Hibiscus / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D019272:Leukocyte Elastase / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D010936:Plant Extracts; D053491:Proteinase Inhibitory Proteins, Secretory; D019272:Leukocyte Elastase