title: High squamous intraepithelial lesion and cancer of lower genital tract in women with anogenital warts.
abstract: OBJECTIVE
  The aim of this paper was to determine the incidence of high-grade squamous intraepithelial lesion (HSIL) and cancer of lower genital tract in patients with anogenital warts and their treatment.
  
  
  METHODS
  Between 1 September 1988 and 30 June 1994, 221 consecutive women with anogenital warts were prospectively examined in the colposcopy outpatient clinic. In 2004, the same group of patients was re-examined.
  
  
  RESULTS
  There were abnormal cytological findings in 111 (50.2%) patients; 31 patients (14.0%) had HSIL, and 6 of them (2.7%) had cancer. There were abnormal colposcopic findings in 152 (68.8%) women; 78 women (35.3%) had abnormal histological findings. In the histological findings, HSIL was found in 41 (18.5%) women and cancer in 6 (2.7%).
  
  
  CONCLUSIONS
  In spite of the fact that anogenital warts are caused by HPV types of low oncogenic risk (6/11), there is an increased incidence of HSIL and cancer in these women. Therefore, women with anogenital warts belong to an increased risk group regarding the cancer of lower genital tract, especially if they are associated with HPV types of a high oncogenic risk.
authors.affiliation: Department of Gynecology and Obstetrics, Clinical Hospital Osijek, J. Huttler 4, 31000 Osijek, Croatia. milojkovic_dr@net.hr
authors.forename: Miodrag
authors.initials: M
authors.lastname: Milojkovic
authors.forename: Dimitrije
authors.initials: D
authors.lastname: Milojkovic
authors.forename: Mico
authors.initials: M
authors.lastname: Rosso
authors.forename: Bojana Vujic
authors.initials: BV
authors.lastname: Vakanjac
mesh_terms: D000328:Adult; D001004:Anus Diseases / Q000821:virology*; D003218:Condylomata Acuminata / Q000150:complications* / Q000821:virology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000473:pathology; D014623:Vaginal Diseases / Q000821:virology*; D014626:Vaginal Smears; D014845:Vulvar Diseases / Q000821:virology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000473:pathology