SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos.
Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.
Lin
Ying-Hung
YH
Graduate Institute of Basic Medical Sciences, Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan.
Chou
Chuan-Kai
CK
Hung
Yu-Ching
YC
Yu
I-Shing
IS
Pan
Hsien-An
HA
Lin
Shu-Wha
SW
Kuo
Pao-Lin
PL
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009028:Morula / Q000473:pathology; D011247:Pregnancy; D058112:Septins / Q000172:deficiency / Q000235:genetics*; D013077:Sperm Head / Q000473:pathology* / Q000502:physiology; D020554:Sperm Injections, Intracytoplasmic
C555146:SEPT12 protein, mouse; D058112:Septins