title: [Porosome: a new organelle and the universal secretion machine in cells].
abstract: A new cell organelle, porosome, discovered in the mid 1990's and its demonstration as the universal secretory machinery in cells is described. In contrast to the generally accepted belief that the secretory vesicle membrane is totally incorporated into the plasma membrane during cell secretion, it has been shown that secretory vesicles transiently dock and fuse with the porosome base via SNARE proteins to expel vesicular contents under intravesicular pressure which is generated by active transport of water through water channels located at the secretory vesicle membrane.
authors.forename: I L
authors.initials: IL
authors.lastname: Lazrishvili
authors.forename: M G
authors.initials: MG
authors.lastname: Zhvaniia
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002477:Cells / Q000378:metabolism* / Q000648:ultrastructure*; D008561:Membrane Fusion; D015388:Organelles / Q000378:metabolism*; D016062:Porosity; D050600:SNARE Proteins / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism
chemical_list: D050600:SNARE Proteins