title: Recent advances in the development of antimuscarinic agents for overactive bladder.
abstract: Pharmacologic therapies (primarily antimuscarinic agents) have been the mainstay of treatment for overactive bladder. In their traditional forms, these drugs produce variable efficacy, a moderate prevalence of side effects, and rare occurrences of cure. The search for newer and better formulations and derivatives of this class of medication (as well as novel therapies) is ongoing, fueled primarily by the high prevalence of overactive bladder and the tremendous number of healthcare dollars spent on current therapy. In the present article, we discuss recent advances in the development of new antimuscarinic agents, important progress in understanding the mechanism of action of this class of drug, and the impact these developments have had on clinical practice.
authors.affiliation: Division of Urology, University of Pennsylvania School of Medicine, 3400 Spruce Street, 9 Penn Tower, Philadelphia, PA 19104, USA. ariana.smith@uphs.upenn.edu
authors.forename: Ariana L
authors.initials: AL
authors.lastname: Smith
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Wein
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015995:Prevalence; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D018727:Muscarinic Antagonists