title: Elevated c-Src and c-Yes expression in malignant skin cancers.
abstract: BACKGROUND
  Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers. However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas.
  
  
  OBJECTIVE
  To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).
  
  
  METHODS
  We examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and c-Yes. In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining.
  
  
  RESULTS
  Western blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin. Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis.
  
  
  CONCLUSIONS
  c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers.
authors.affiliation: Molecular Cancer Research Center, College of Medicine, Soonchunhyang University, Chunan, Korea.
authors.forename: Jang Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Pyon
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Sang Han
authors.initials: SH
authors.lastname: Lee
authors.forename: Hae Seon
authors.initials: HS
authors.lastname: Nam
authors.forename: Chul Han
authors.initials: CH
authors.lastname: Kim
authors.forename: Sang Gue
authors.initials: SG
authors.lastname: Kang
authors.forename: Yoon Jin
authors.initials: YJ
authors.lastname: Lee
authors.forename: Mi Youn
authors.initials: MY
authors.lastname: Park
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Jeong
authors.forename: Moon Kyun
authors.initials: MK
authors.lastname: Cho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D000081247:CSK Tyrosine-Protein Kinase; D002280:Basal Cell Carcinoma / Q000201:enzymology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000201:enzymology* / Q000473:pathology; D008875:Middle Aged; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D051575:Proto-Oncogene Proteins c-yes / Q000032:analysis*; D056910:Republic of Korea; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology; D019061:src-Family Kinases
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D051575:Proto-Oncogene Proteins c-yes; C489834:YES1 protein, human; D019061:src-Family Kinases; C000631346:CSK protein, human
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