An experimental and computational study on the epimeric contribution to the infrared spectrum of budesonide.
Budesonide is a mixture of 22R and 22S epimers. The epimeric content of budesonide was reported in both British and European pharmacopoeias to be within the range of 60-49/40-51 for R and S epimers, respectively. In this work, contribution of the two epimers to the overall infrared spectrum of budesonide has been investigated by quantum chemical calculations.
Ali
H R H
HR
Department of Pharmaceutical Analytical Chemistry, University of Assiut, Egypt. hareha11374@gmail.com
Edwards
H G M
HG
Kendrick
J
J
Munshi
T
T
Scowen
I J
IJ
D019819:Budesonide / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D013237:Stereoisomerism; D014732:Vibration; D014961:X-Ray Diffraction
D019819:Budesonide