A hydrotropic β-cyclodextrin grafted hyperbranched polyglycerol co-polymer for hydrophobic drug delivery.
The development of successful formulations for poorly water soluble drugs remains a longstanding, critical, and challenging issue in cancer therapy. A β-cyclodextrin (CD) functionalized hyperbranched polyglycerol (HPG) has been prepared as a potential water insoluble drug carrier. The HPG-g-CD molecules could self-assemble into multimolecular spherical micelles in water, the size of which ranged from 200 to 300 nm, with good dispersity. A high loading capacity and high encapsulation efficiency of paclitaxel, as a model, were obtained. The release profiles of different co-polymer compositions showed a burst release followed by continuous extended release. Furthermore, MTT analysis showed that HPG-g-CD had good biocompatibility, indicating that HPG-g-CD may be considered a promising hydrophobic drug delivery system.
Zhang
Xuejiao
X
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Zhang
Xinge
X
Wu
Zhongming
Z
Gao
Xiujun
X
Cheng
Cui
C
Wang
Zhen
Z
Li
Chaoxing
C
D002152:Calorimetry, Differential Scanning; D017666:Deuterium Oxide / Q000737:chemistry; D016503:Drug Delivery Systems; D005990:Glycerol / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D017239:Paclitaxel / Q000494:pharmacology; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D044967:Serum; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D047392:beta-Cyclodextrins / Q000737:chemistry*
D011108:Polymers; D047392:beta-Cyclodextrins; C043941:polyglycerol; D017666:Deuterium Oxide; D017239:Paclitaxel; D005990:Glycerol