title: No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial.
abstract: OBJECTIVE
  We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.
  
  
  METHODS
  Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 microg/day calcitriol or placebo and followed-up for 2 years.
  
  
  RESULTS
  At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point.
  
  
  CONCLUSIONS
  At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis.
authors.affiliation: Department of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Bizzarri
authors.forename: Dario
authors.initials: D
authors.lastname: Pitocco
authors.forename: Nicola
authors.initials: N
authors.lastname: Napoli
authors.forename: Enrico
authors.initials: E
authors.lastname: Di Stasio
authors.forename: Daria
authors.initials: D
authors.lastname: Maggi
authors.forename: Silvia
authors.initials: S
authors.lastname: Manfrini
authors.forename: Concetta
authors.initials: C
authors.lastname: Suraci
authors.forename: Maria Gisella
authors.initials: MG
authors.lastname: Cavallo
authors.forename: Marco
authors.initials: M
authors.lastname: Cappa
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ghirlanda
authors.forename: Paolo
authors.initials: P
authors.lastname: Pozzilli
mesh_terms: D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000378:metabolism; D002117:Calcitriol / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D055815:Young Adult
chemical_list: D002096:C-Peptide; D002117:Calcitriol; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin
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