title: Effect of hemodialysis and peritoneal dialysis on redox status in chronic renal failure patients: a comparative study.
abstract: OBJECTIVE
  To investigate the effects of hemodialysis (HD) and periotoneal dialysis (PD) on oxidative stress in chronic renal failure patients (CRF).
  
  
  METHODS
  20 HD patients (M/F: 8/12, 36 ± 12 years) and 20 PD patients (M/F: 10/10, 40 ± 8 years) were compared with 20 end stage renal failure patients (CRF) (M/F: 4/16, 61 ± 13 years).
  
  
  RESULTS
  Thiobarbituric acid reactive substances (TBARS) values were elevated in HD and decreased in PD compared to CRF (P < 0.05). TBARS-VLDL and TBARS-HDL2 were decreased in HD and PD, compared to CRF (p < 0.05). TBARS-LDL were higher in HD compared to CRF (p < 0.05). No significant difference in TBARS-HDL3 values between the three groups. Carbonyls were increased in HD (p < 0.05) and PD (p < 0.01) compared to CRF. Plasma superoxide dismutase activity (SOD) was decreased in HD compared to CRF and PD (P < 0.05). Glutathion peroxidase activity (GSH-Px) was decreased in HD and PD (P < 0.005), compared to CRF. Decrease in catalase activity was noted only in PD compared to CRF (P < 0.05). An increase in nitric oxide was noted in HD compared to CRF (p < 0.05). Albumin concentrations were higher in HD and PD compared to CRF (P < 0.001). Whereas uric acid concentrations were decreased in HD (P < 0.001) compared to CRF and PD. Bilirubin values were similar in all groups. Increased values of iron were noted in HD and PD, compared to PD (p < 0.001).
  
  
  CONCLUSIONS
  HD and PD aggravate oxidative stress generated by uremia. HD accentuates lipid and protein peroxidation, while PD aggravates protein oxidation. However, the activity of antioxidant enzymes was altered by both dialysis treatments.
authors.affiliation: Laboratoire de Nutrition Clinique et Métabolique, Département de Biologie, Faculté des Sciences, Université d'Oran 31100, Algérie. khmekki@hotmail.com
authors.forename: Khedidja
authors.initials: K
authors.lastname: Mekki
authors.forename: Warda
authors.initials: W
authors.lastname: Taleb
authors.forename: Nassima
authors.initials: N
authors.lastname: Bouzidi
authors.forename: Abbou
authors.initials: A
authors.lastname: Kaddous
authors.forename: Malika
authors.initials: M
authors.lastname: Bouchenak
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D002374:Catalase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008074:Lipoproteins / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D050050:Protein Carbonylation; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014511:Uremia / Q000097:blood / Q000628:therapy; D055815:Young Adult
chemical_list: C422455:ALB protein, human; D006023:Glycoproteins; D008074:Lipoproteins; D012709:Serum Albumin; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D007501:Iron; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000075462:Serum Albumin, Human
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