[Perinatal outcomes in pregnant women with diabetes mellitus and different level of autoantibodies to insulin and its receptors].
The levels of idiotypic (AB1) and antiidiotypic (AB2) antibodies were investigated in pregnants (n = 248) suffer from diabetes. It was proved that AB2 to insulin conditionally can be regards as antibodies to insulin receptor. It was shown that condition of newborns much depends on levels of these antibodies and their proportion. Condition of newborns from women with isolated high levels of AB1 to insulin was much better in comparison with ones from mothers with isolated high levels of AB2 to insulin. Conception about mechanisms of acting of AB1 and AB2 to insulin on fetus was represented.
Protsenko
A M
AM
Budykina
T S
TS
Morozov
S G
SG
Rybakov
A S
AS
Gribova
I E
IE
Protsenko
A N
AN
D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn; D007328:Insulin / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011254:Pregnancy in Diabetics / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007074:Immunoglobulin G; D007328:Insulin