title: Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.
abstract: As endosymbionts, the mitochondria are unique among organelles. This review provides insights into mitochondrial behavior and introduces the idea of a unified collective, an interconnected reticulum reminiscent of the Borg, a fictional humanoid species from the Star Trek television series whereby decisions are made within their network (or "hive"), linked to signaling cascades that coordinate the cross-talk between mitochondrial and cellular processes ("subspace domain"). Similarly, mitochondrial dynamics are determined by two distinct processes, namely the local regulation of fission/fusion and the global control of their behavior through cellular signaling pathways. Indeed, decisions within the hive provide each mitochondrial unit with autonomous control of their own degradation, whereby mitochondrial fusion is inactivated and they become substrates for autophagy. Decisions within the subspace domain couple signaling pathways involved in the functional integration of mitochondria with complex cellular transitions, including developmental cues, mitosis, and apoptosis.
authors.affiliation: University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
authors.forename: Emelie
authors.initials: E
authors.lastname: Braschi
authors.forename: Heidi M
authors.initials: HM
authors.lastname: McBride
mesh_terms: D000818:Animals; D004194:Disease; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D015398:Signal Transduction
references.citation: J Biol Chem. 2005 May 13;280(19):18598-603
references.pmid: 15760898
references.citation: Nat Cell Biol. 2010 Feb;12(2):119-31
references.pmid: 20098416
references.citation: Cell. 2001 Sep 21;106(6):735-44
references.pmid: 11572779
references.citation: Mol Cell. 2004 Oct 8;16(1):59-68
references.pmid: 15469822
references.citation: Circulation. 2010 May 11;121(18):2012-22
references.pmid: 20421521
references.citation: Cell. 2006 Jul 14;126(1):177-89
references.pmid: 16839885
references.citation: Nature. 2008 Dec 4;456(7222):605-10
references.pmid: 19052620
references.citation: Annu Rev Genet. 2006;40:159-85
references.pmid: 16771627
references.citation: EMBO Rep. 2009 Jul;10(7):748-54
references.pmid: 19407830
references.citation: EMBO J. 2006 Aug 9;25(15):3618-26
references.pmid: 16874301
references.citation: Dev Cell. 2001 Oct;1(4):515-25
references.pmid: 11703942
references.citation: J Cell Biol. 2010 Apr 19;189(2):211-21
references.pmid: 20404107
references.citation: EMBO J. 2008 Jan 23;27(2):433-46
references.pmid: 18200046
references.citation: PLoS One. 2008 Jan 23;3(1):e1487
references.pmid: 18213395
references.citation: J Cell Biol. 1999 Nov 29;147(5):981-94
references.pmid: 10579719
references.citation: J Cell Biol. 2007 Apr 9;177(1):39-49
references.pmid: 17403926
references.citation: Nature. 2010 Feb 11;463(7282):744-5
references.pmid: 20148026
references.citation: Mol Cell. 2005 Sep 16;19(6):727-40
references.pmid: 16153868
references.citation: Nature. 1981 Apr 9;290(5806):457-65
references.pmid: 7219534
references.citation: Sci Signal. 2009 Aug 18;2(84):ra47
references.pmid: 19690333
references.citation: J Cell Biol. 2009 Dec 28;187(7):959-66
references.pmid: 20038677
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2653-8
references.pmid: 16477035
references.citation: EMBO J. 2001 Aug 1;20(15):4107-21
references.pmid: 11483514
references.citation: J Cell Biol. 2003 Jan 20;160(2):189-200
references.pmid: 12527753
references.citation: J Cell Sci. 2010 Feb 15;123(Pt 4):619-26
references.pmid: 20103533
references.citation: Cell Metab. 2010 May 5;11(5):412-26
references.pmid: 20444421
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15803-8
references.pmid: 18838687
references.citation: N Engl J Med. 2010 Jun 3;362(22):2132-4
references.pmid: 20519686
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43
references.pmid: 18230723
references.citation: Cell. 2005 Sep 9;122(5):669-82
references.pmid: 16125763
references.citation: J Exp Med. 2008 Sep 29;205(10):2397-408
references.pmid: 18809716
references.citation: Cell. 2007 Aug 10;130(3):548-62
references.pmid: 17693261
references.citation: J Biol Chem. 2010 Apr 9;285(15):11740-52
references.pmid: 20164189
references.citation: EMBO J. 2009 Jun 3;28(11):1589-600
references.pmid: 19360003
references.citation: Hum Mol Genet. 2009 Oct 15;18(R2):R169-76
references.pmid: 19808793
references.citation: J Biol Chem. 2010 Apr 16;285(16):11818-26
references.pmid: 20172858
references.citation: J Exp Biol. 2003 Jun;206(Pt 12):1985-92
references.pmid: 12756280
references.citation: J Cell Biol. 2009 Sep 21;186(6):805-16
references.pmid: 19752021
references.citation: Curr Opin Cell Biol. 2009 Aug;21(4):560-7
references.pmid: 19423315
references.citation: J Biol Chem. 1998 Aug 7;273(32):20150-5
references.pmid: 9685359
references.citation: J Alzheimers Dis. 2010;20 Suppl 2:S513-26
references.pmid: 20463395
references.citation: EMBO Rep. 2010 Feb;11(2):133-8
references.pmid: 20019757
references.citation: J Neurosci. 2009 Jul 15;29(28):9090-103
references.pmid: 19605646
references.citation: EMBO Rep. 2007 Oct;8(10):939-44
references.pmid: 17721437
references.citation: Hum Mol Genet. 2009 Feb 15;18(4):737-52
references.pmid: 19039036
references.citation: J Biol Chem. 2007 Jul 27;282(30):21583-7
references.pmid: 17553808
references.citation: Genes Dev. 2008 Jun 15;22(12):1577-90
references.pmid: 18559474
references.citation: Mitochondrion. 2010 Jun;10(4):316-20
references.pmid: 20206303
references.citation: Science. 2007 Nov 9;318(5852):977-80
references.pmid: 17991864
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11960-5
references.pmid: 19617534
references.citation: Cell Death Differ. 2010 Nov;17(11):1785-94
references.pmid: 20489733
references.citation: FASEB J. 2009 Nov;23(11):3917-27
references.pmid: 19638400
references.citation: PLoS Biol. 2010 Jan 26;8(1):e1000298
references.pmid: 20126261
references.citation: Science. 1995 Feb 10;267(5199):836-7
references.pmid: 7846528
references.citation: Nat Cell Biol. 2009 Aug;11(8):958-66
references.pmid: 19578372
references.citation: Nat Immunol. 2005 Oct;6(10):981-8
references.pmid: 16127453
references.citation: J Cell Biol. 1998 Oct 19;143(2):359-73
references.pmid: 9786948
references.citation: J Cell Sci. 2007 Apr 1;120(Pt 7):1178-88
references.pmid: 17341580
references.citation: Semin Cell Dev Biol. 2010 Aug;21(6):575-81
references.pmid: 20079451
references.citation: J Cell Biol. 2007 Jul 2;178(1):71-84
references.pmid: 17606867
references.citation: Cell Death Differ. 1997 Aug;4(6):443-56
references.pmid: 16465265
references.citation: Biochim Biophys Acta. 1999 Feb 9;1410(2):159-70
references.pmid: 10076024
references.citation: Mol Biol Cell. 2008 Jun;19(6):2457-64
references.pmid: 18353967
references.citation: Science. 2009 Apr 3;324(5923):102-5
references.pmid: 19342591
references.citation: PLoS One. 2010 Apr 07;5(4):e10054
references.pmid: 20383334
references.citation: Curr Biol. 2008 Jan 22;18(2):102-8
references.pmid: 18207745
references.citation: Nature. 2007 Nov 29;450(7170):736-40
references.pmid: 18046414
references.citation: Diabetologia. 2010 Jan;53(1):160-9
references.pmid: 19847394
references.citation: J Cell Biol. 2007 May 7;177(3):439-50
references.pmid: 17470634
references.citation: Curr Biol. 2004 Feb 17;14(4):340-5
references.pmid: 14972687
references.citation: J Theor Biol. 1967 Mar;14(3):255-74
references.pmid: 11541392
references.citation: Mol Biol Cell. 2009 Dec;20(23):5026-35
references.pmid: 19812251
references.citation: Nature. 1996 May 23;381(6580):335-41
references.pmid: 8692274
references.citation: J Biol Chem. 2007 Apr 13;282(15):11521-9
references.pmid: 17301055
references.citation: Annu Rev Biochem. 2007;76:751-80
references.pmid: 17362197
references.citation: Dev Cell. 2002 Jan;2(1):55-67
references.pmid: 11782314
references.citation: Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63
references.pmid: 16025099
references.citation: J Biol Chem. 2009 Jun 26;284(26):17783-95
references.pmid: 19411255
references.citation: J Cell Biol. 2008 Aug 11;182(3):573-85
references.pmid: 18695047
references.citation: Biochim Biophys Acta. 2009 Jan;1793(1):20-6
references.pmid: 18691613
references.citation: Diabetologia. 2010 Aug;53(8):1783-94
references.pmid: 20461356
references.citation: Curr Biol. 2004 Jul 27;14(14):1272-6
references.pmid: 15268858
references.citation: Biophys J. 2009 May 6;96(9):3509-18
references.pmid: 19413957
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):378-83
references.pmid: 19966284
references.citation: EMBO Rep. 2006 Oct;7(10):1019-22
references.pmid: 16936636
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5018-23
references.pmid: 20194754
references.citation: J Biol Chem. 2004 Apr 9;279(15):15323-9
references.pmid: 14732705
references.citation: Mol Cell Endocrinol. 2010 May 14;320(1-2):25-33
references.pmid: 20144685
references.citation: Biochem J. 2010 May 13;428(2):133-45
references.pmid: 20462400
references.citation: Mitochondrion. 2002 May;1(5):425-35
references.pmid: 16120295
references.citation: J Cell Biol. 2009 Dec 28;187(7):1023-36
references.pmid: 20038678
references.citation: Cell Res. 2008 Sep;18(9):900-10
references.pmid: 18591963
references.citation: Cell. 2010 Apr 16;141(2):280-9
references.pmid: 20403324
references.citation: Hum Mol Genet. 2010 Apr 15;19(R1):R28-37
references.pmid: 20385539
references.citation: Nature. 2005 Oct 20;437(7062):1167-72
references.pmid: 16177806
references.citation: Nature. 2010 Mar 4;464(7285):104-7
references.pmid: 20203610