title: Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice.
abstract: Taurine, a sulfur-containing beta-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardiac and skeletal muscles. Meanwhile, taurine deficiency leads various pathologies, including dilated cardiomyopathy, in cat and fox. However, the essential role of taurine depletion on pathogenesis has not been fully clarified. To address the physiological role of taurine in mammalian tissues, taurine transporter-(TauT-) knockout models were recently generated. TauTKO mice exhibited loss of body weight, abnormal cardiac function and the reduced exercise capacity with tissue taurine depletion. In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice.
authors.affiliation: Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
authors.forename: Shohei
authors.initials: S
authors.lastname: Oishi
authors.forename: Mika
authors.initials: M
authors.lastname: Takai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Uozumi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Schaffer
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D010805:Physical Conditioning, Animal; D013654:Taurine / Q000172:deficiency; D000099247:Taurine Transporters
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D013654:Taurine; D000099247:Taurine Transporters
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