title: Two new drimane sesquiterpenoids from compound Changweikang and their inhibitory activity against nitric oxide production.
abstract: Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, PR China.
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Liu
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Xiao-po
authors.initials: XP
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Sheng
authors.forename: Jun-qing
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Sheng-li
authors.initials: SL
authors.lastname: Kang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D029624:Ferns / Q000737:chemistry; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008958:Models, Molecular; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D000081223:Polycyclic Sesquiterpenes; D028502:Polygonum / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C554912:changweikangic acid A; C554913:changweikangic acid B; C437376:drimane; D009569:Nitric Oxide