Isolation of putative biosynthetic intermediates of prenylated indole alkaloids from a thermophilic fungus Talaromyces thermophilus.
The putative key biosynthetic intermediates of prenylated indole alkaloids have long been proposed but never isolated. Two such alkaloids, named talathermophilins A and B (1 and 2), were isolated from a thermophilic fungus Talaromyces thermophilus strain YM1-3 and were identified by NMR and MS spectroscopic analyses. The ratio of 1 and 2 in the culture broths was unexpectedly rather constant (about 2:3), which even remained unchanged despite the addition of exogenous 1 or 2, suggesting that talathermophilins might be of special function for the extremophilic fungus.
Chu
Yan-Sheng
YS
Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, PR China.
Niu
Xue-Mei
XM
Wang
Yan-Li
YL
Guo
Ji-Peng
JP
Pan
Wen-Zheng
WZ
Huang
Xiao-Wei
XW
Zhang
Ke-Qin
KQ
D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D054876:Prenylation; D032901:Talaromyces / Q000737:chemistry* / Q000378:metabolism
D026121:Indole Alkaloids