The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility.
OBJECTIVE
To explore the roles of leptin, monocyte chemotactic protein (MCP)-1, and tumour necrosis factor (TNF)-α in the peritoneal fluid (PF) in the pathogenesis of endometriosis-associated infertility.


METHODS
Leptin, MCP-1, and TNF-α levels in the PF from 28 infertile women with endometriosis (study group), 23 women with fallopian-associated infertility (controls), and 24 women with myoma (controls) were determined by performing enzyme-linked immunosorbent assay (ELISA).


RESULTS
Leptin and TNF-α levels in the PF showed no significant difference among three groups. The MCP-1 level in patients with endometriosis was higher than those in fallopian-associated infertility group and myoma group (P < 0.01). There was a positive correlation between leptin and MCP-1 levels in the PF of patients with endometriosis (P < 0.05).


CONCLUSIONS
Peritoneal leptin and MCP-1 play important roles in the pathogenesis of infertility in the early stage of endometriosis.
Tao
Yu
Y
Department of Obstetrics/Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Zhang
Qiang
Q
Huang
Wei
W
Zhu
HuiLi
H
Zhang
Dongxue
D
Luo
Wanying
W
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry / Q000473:pathology; D018932:Chemokine CCL2 / Q000378:metabolism*; D004715:Endometriosis / Q000150:complications / Q000276:immunology* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D020738:Leptin / Q000378:metabolism*; D009214:Myoma / Q000276:immunology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha