Effects of Scutellariae radix and Aloe vera gel extracts on immunoglobulin E and cytokine levels in atopic dermatitis NC/Nga mice.
OBJECTIVE
The present study aimed to investigate the effects of Scutellariae radix (SR) and Aloe vera gel (AV), alone or in combination, on levels of immunoglobulin E (IgE) and inflammatory cytokines in spontaneous atopic dermatitis(AD)-like skin lesions.


METHODS
After spontaneous AD-like skin lesion was developed by adaptation to conventional conditions, mice were randomly assigned to control, SR (50 mg/kg, p.o.), AV (0.8 mg/kg, p.o.) and SRAV (50 mg of SR and 0.8 mg of AV/kg, p.o.) groups, and were treated for 6 weeks.


RESULTS
SR and SRAV suppressed IL-5 levels compared with control, but had no effects on IgE levels (P<0.05). AV increased IgE levels, but decreased both IL-5 and IL-10 compared with control (P<0.05).


CONCLUSIONS
These results suggest that SR and AV modulate immunological responses in AD, mainly through influencing IL-5 or IL-10 levels.
Kim
Jinkyung
J
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea.
Lee
In seok
Is
Park
Soojin
S
Choue
Ryowon
R
D000504:Aloe; D000818:Animals; D016207:Cytokines / Q000097:blood*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology*; D031364:Scutellaria baicalensis; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology
D016207:Cytokines; D007155:Immunologic Factors; D010936:Plant Extracts; D007073:Immunoglobulin E