Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome.
OBJECTIVE
To explore the serum anti-mullerian hormone (AMH) level in adolescent and young adult Chinese patients with polycystic ovary syndrome (PCOS), and to evaluate its diagnostic value for PCOS.


METHODS
Serum AMH was measured in a cohort of 47 adolescent and young adult Chinese patients with PCOS and 40 age-matched controls. Its diagnostic potential was evaluated by Receiver Operating Characteristic (ROC) curves.


RESULTS
The serum AMH level was higher in PCOS patients than in controls (9.85 ± 4.93 ng/mL vs. 7.13 ± 3.02 ng/mL, P = 0.002), and positively related to the mean ovarian volume in PCOS patients (r = 0.319, P = 0.029). The area under the ROC curve for AMH reached a value of 0.664 (0.551-0.778, 95% confidence interval). The best compromise between specificity (70%) and sensitivity (61.7%) was obtained with a cut-off value of 8 ng/mL.


CONCLUSIONS
Serum AMH levels are elevated in adolescent and young adult Chinese patients of PCOS. Serum AMH measurement offers a relatively poor diagnostic potency with a sensitivity of 61.7% and a specificity of 70% at 8 ng/mL.
Li
Lin
L
Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Chen
Xiaoli
X
Mo
Yaqin
Y
Chen
Yaxiao
Y
Wenig
Meiying
M
Yang
Dongzi
D
D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
D015415:Biomarkers; D054304:Anti-Mullerian Hormone
Mol Cell Endocrinol. 2008 Jan 30;282(1-2):95-100
18191888
Clin Endocrinol (Oxf). 2005 Sep;63(3):267-73
16117813
Am J Obstet Gynecol. 2007 Jan;196(1):77.e1-5
17240243
Reproduction. 2002 Nov;124(5):601-9
12416998
Mol Hum Reprod. 2004 Feb;10(2):77-83
14742691
Exp Biol Med (Maywood). 2004 May;229(5):369-77
15096648
Endocrinology. 1995 Nov;136(11):4951-62
7588229
Ultrasound Obstet Gynecol. 2008 Oct;32(5):700-3
18773451
J Clin Endocrinol Metab. 2004 Jan;89(1):318-23
14715867
Int J Gynaecol Obstet. 2007 May;97(2):129-34
17368460
Hum Reprod Update. 2005 Mar-Apr;11(2):143-60
15705960
Zhonghua Fu Chan Ke Za Zhi. 2007 Sep;42(9):590-4
17983512
J Reprod Fertil. 1987 Jul;80(2):509-16
3309279
Trends Endocrinol Metab. 2008 Nov;19(9):340-7
18805020
J Clin Endocrinol Metab. 2003 Dec;88(12):5957-62
14671196
Development. 1991 Oct;113(2):613-24
1782869
Hum Reprod. 2004 Jan;19(1):41-7
14688154
Cell. 1986 Jun 6;45(5):685-98
3754790
Eur J Obstet Gynecol Reprod Biol. 2008 Jul;139(1):59-64
18378061
Reproduction. 2006 Jan;131(1):1-9
16388003
J Clin Endocrinol Metab. 2006 Mar;91(3):941-5
16368745
Fertil Steril. 2002 Feb;77(2):357-62
11821097
Hum Reprod. 2006 Aug;21(8):2027-32
16684838
Neuro Endocrinol Lett. 2007 Dec;28(6):807-10
18063948