title: Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.
abstract: OBJECTIVE
  A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population.
  
  
  METHODS
  Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Result. SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944.
  
  
  CONCLUSIONS
  This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS.
authors.affiliation: Laboratory of Rheumatology, Puerta de Hierro University Hospital, C/Joaquín Rodrigo 2, Majadahonda 28222, Madrid, Spain. malejandra_sanchez@yahoo.es
authors.forename: Alejandra
authors.initials: A
authors.lastname: Sánchez
authors.forename: Magdalena
authors.initials: M
authors.lastname: Szczypiorska
authors.forename: Xavier
authors.initials: X
authors.lastname: Juanola
authors.forename: Nerea
authors.initials: N
authors.lastname: Bartolomé
authors.forename: Jordi
authors.initials: J
authors.lastname: Gratacós
authors.forename: Pedro
authors.initials: P
authors.lastname: Zarco
authors.forename: Eduardo
authors.initials: E
authors.lastname: Collantes
authors.forename: Marta
authors.initials: M
authors.lastname: Artieda
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez
authors.forename: Diego
authors.initials: D
authors.lastname: Tejedor
authors.forename: Juan
authors.initials: J
authors.lastname: Mulero
mesh_terms: D000328:Adult; D000483:Alleles; D021901:DNA, Intergenic / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012042:Registries; D013030:Spain; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: D021901:DNA, Intergenic