Modular synthesis of polyphenolic benzofurans, and application in the total synthesis of malibatol a and shoreaphenol.
A modular strategy for the synthesis of hexacyclic dimeric resveratrol polyphenolic benzofurans is reported. The developed synthetic technology was applied to the total synthesis of malibatol A, shoreaphenol, and other biologically relevant poly-phenols.
Chen
David Y-K
DY
Chemical Synthesis Laboratory at Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, No. 03-08, 138667, Singapore. david_chen@ices.a-star.edu.sg
Kang
Qiang
Q
Wu
T Robert
TR
D001572:Benzofurans / Q000138:chemical synthesis; D057930:Click Chemistry / Q000379:methods*; D053958:Dipterocarpaceae / Q000737:chemistry*; D005419:Flavonoids; D010636:Phenols / Q000138:chemical synthesis*; D059808:Polyphenols; D013267:Stilbenes / Q000138:chemical synthesis*
D001572:Benzofurans; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013267:Stilbenes; C111734:malibatol A
Curr Drug Metab. 2008 Oct;9(8):710-29
18855609
Org Lett. 2003 Apr 17;5(8):1191-2
12688716
J Am Chem Soc. 2010 Jun 2;132(21):7540-8
20462209
Angew Chem Int Ed Engl. 2007;46(43):8186-91
17890663
FEBS J. 2008 Nov;275(22):5512-26
18959740
Arch Biochem Biophys. 2008 Aug 15;476(2):107-12
18284912
Org Biomol Chem. 2009 Jul 7;7(13):2788-95
19532996
Arch Toxicol. 2009 Jan;83(1):11-21
19002670
J Am Chem Soc. 2009 Feb 11;131(5):1753-65
19143488
J Nat Prod. 1998 Mar;61(3):351-3
9544565
Angew Chem Int Ed Engl. 2009;48(19):3440-3
19280619
Chem Pharm Bull (Tokyo). 2001 Jun;49(6):785-7
11411540