Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats.
Perinatal exposure to polychlorinated biphenyls (PCBs) leads to significant alterations of neural and hormonal systems. These alterations have been shown to impair motor and sensory development. Less is known about the influence of PCB exposure on developing emotional and motivational systems involved in social interactions and social learning. The present study examined the impact of perinatal PCB exposure (mixture of congeners 47 and 77) on social recognition in juvenile animals, conspecific-directed investigation in adults and on neural and hormonal systems involved in social functions. We used a standard habituation-dishabituation paradigm to evaluate juvenile recognition and a social port paradigm to monitor adult social investigation. Areal measures of the periventricular nucleus (PVN) of the hypothalamus were obtained to provide correlations with related hormone and brain systems. PCB exposed rats were significantly impaired in social recognition as indicated by persistent conspecific-directed exploration by juvenile animals regardless of social experience. As adults, PCB exposure led to a dampening of the isolation-induced enhancement of social investigation. There was not a concomitant alteration of social investigation in pair-housed PCB exposed animals at this stage of development. Interestingly, PVN area was significantly decreased in juvenile animals exposed to PCB during the perinatal period. Shifts in hypothalamic regulation of hormones involved in social behavior and stress could be involved in the behavioral changes observed. Overall, the results suggest that PCB exposure impairs context or experience-dependent modulation of social approach and investigation. These types of social-context deficits are similar to behavioral deficits observed in social disorders such as autism and other pervasive developmental disorders.
Jolous-Jamshidi
Banafsheh
B
Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403-0208, USA.
Cromwell
Howard C
HC
McFarland
Ashley M
AM
Meserve
Lee A
LA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D008297:Male; D009042:Motivation / Q000187:drug effects; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000473:pathology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012919:Social Behavior; D012934:Social Isolation
D011078:Polychlorinated Biphenyls
Environ Health Perspect. 2010 Jun;118(6):796-802
20146964
Bull Environ Contam Toxicol. 1992 May;48(5):715-20
1324039
Environ Health Perspect. 2009 Sep;117(9):1454-60
19750113
Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):830-9
16702358
Nature. 2010 Mar 18;464(7287):413-7
20182426
Physiol Behav. 2005 Jan 31;84(1):81-6
15642610
Environ Int. 2007 Apr;33(3):397-405
17270272
Environ Health Perspect. 2008 Oct;116(10):1416-22
18941588
Physiol Behav. 2007 Aug 15;91(5):658-66
17498760
Toxicology. 2004 Oct 15;203(1-3):99-107
15363586
Toxicol Appl Pharmacol. 2009 Aug 15;239(1):46-54
19464308
Behav Brain Res. 2009 Jun 25;200(2):323-35
19150375
Horm Behav. 2007 Mar;51(3):364-72
17274994
Prog Neurobiol. 2008 Jan;84(1):1-24
18053631
Physiol Behav. 1986;37(6):869-73
3786481
Anim Behav. 1999 Sep;58(3):629-634
10479378
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Oct;27(4):286-300
19953400
Behav Neurosci. 1999 Jun;113(3):602-11
10443786
Ann Ist Super Sanita. 2006;42(4):410-6
17361063
Dev Psychobiol. 2008 May;50(4):322-31
18393285
ILAR J. 2009;50(1):43-50
19106451
Eur Neuropsychopharmacol. 1991 Dec;1(4):555-60
1668316
Toxicol Sci. 2004 Dec;82(2):577-89
15456922
Environ Health Perspect. 1996 Apr;104 Suppl 2:299-305
9182036
Toxicol Sci. 2005 Jul;86(1):125-31
15843507
Dev Psychobiol. 1982 Jan;15(1):1-8
7054012
Environ Health Perspect. 2005 Jun;113(6):700-7
15929892
Toxicol Ind Health. 2000 Sep;16(7-8):305-33
11693948
Arch Environ Contam Toxicol. 1975-1976;3(4):479-90
816261
Neurotoxicol Teratol. 1988 May-Jun;10(3):193-7
3211096
Appl Anim Behav Sci. 2000 Apr 3;67(3):241-254
10736532
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7646-51
17460041
J Comp Neurol. 2009 Nov 10;517(2):156-65
19731312
Front Behav Neurosci. 2009 Jun 29;3:10
19587848
Pharmacol Biochem Behav. 1997 Nov;58(3):643-7
9329053
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1173-7
19563853
Tohoku J Exp Med. 2007 Jun;212(2):151-7
17548959
Eur Neuropsychopharmacol. 1991 May;1(2):123-6
1821701
Reprod Toxicol. 2008 Aug;25(4):447-54
18502095
Front Neuroendocrinol. 2009 Oct;30(4):497-518
19341763
Endocrinology. 2008 Jul;149(7):3256-63
18356275
Neurotoxicol Teratol. 1987 Jan-Feb;9(1):51-7
3627077
Brain Pathol. 2007 Oct;17(4):448-59
17919130
Toxicology. 1999 Oct 29;138(1):11-7
10566587
Ross Fiziol Zh Im I M Sechenova. 2001 Jun;87(6):730-51
11534200
Neurotoxicol Teratol. 1997 Sep-Oct;19(5):383-9
9380005
Contemp Top Lab Anim Sci. 2003 Mar;42(2):29-30
19757622
Growth Dev Aging. 1996 Autumn-Winter;60(3-4):131-43
9007564
Biol Reprod. 2008 Jun;78(6):1091-101
18305224
Physiol Behav. 2001 Oct;74(3):363-70
11714501
J Neuroendocrinol. 2008 Jun;20(6):858-65
18601710
Rev Environ Health. 2006 Jan-Mar;21(1):1-23
16700427
Toxicol Sci. 2002 Jan;65(1):52-61
11752685
Neurotoxicology. 2010 Jan;31(1):17-25
19854214
Neuropharmacology. 2007 Mar;52(3):724-32
17097693
Prog Neuropsychopharmacol Biol Psychiatry. 1999 Jul;23(5):915-28
10509384
Physiol Behav. 2010 Feb 9;99(2):260-8
19758571
Physiol Behav. 2008 Oct 20;95(3):471-5
18680757
J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):351-72
18368561
Physiol Behav. 2005 Jun 2;85(2):83-91
15878184
Pol J Vet Sci. 2006;9(2):101-8
16780177
Toxicol Sci. 2007 Jul;98(1):178-86
17434953
Neurotoxicol Teratol. 2006 Mar-Apr;28(2):260-77
16487679
Toxicol Appl Pharmacol. 1995 Nov;135(1):77-88
7482542
Neurotoxicol Teratol. 1999 Jul-Aug;21(4):435-43
10440487
Neurotoxicology. 1998 Aug-Oct;19(4-5):517-25
9745906
Environ Health Perspect. 2002 Oct;110(10):A593-8
12361940
Environ Health Perspect. 2006 Feb;114(2):194-201
16451854
Arch Toxicol. 1998 Apr;72(5):314-7
9630019
Behav Neurosci. 2004 Apr;118(2):298-305
15113254
Dev Psychobiol. 1999 Mar;34(2):129-38
10086231
Neurosci Biobehav Rev. 2005;29(4-5):843-65
15893378
Endocrine. 2001 Mar;14(2):235-46
11394642
Physiol Behav. 2002 Apr 15;75(5):689-96
12020734
Rev Environ Health. 2007 Oct-Dec;22(4):313-28
18351230
Dev Psychobiol. 1992 May;25(4):261-74
1624056
Rev Environ Contam Toxicol. 2009;201:137-58
19484591
Neurotoxicology. 2009 May;30(3):331-7
19442816
Stress. 2009 May;12(3):250-8
18951246
Physiol Behav. 2009 Aug 4;98(1-2):247-50
19447123