title: International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.
abstract: The 2009 International Society of Urological Pathology consensus conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the substaging of pT2 prostate cancers according to the TNM 2002/2010 system, reporting of tumor size/volume and zonal location of prostate cancers were coordinated by working group 2. A survey circulated before the consensus conference demonstrated that 74% of the 157 participants considered pT2 substaging of prostate cancer to be of clinical and/or academic relevance. The survey also revealed a considerable variation in the frequency of reporting of pT2b substage prostate cancer, which was likely a consequence of the variable methodologies used to distinguish pT2a from pT2b tumors. Overview of the literature indicates that current pT2 substaging criteria lack clinical relevance and the majority (65.5%) of conference attendees wished to discontinue pT2 substaging. Therefore, the consensus was that reporting of pT2 substages should, at present, be optional. Several studies have shown that prostate cancer volume is significantly correlated with other clinicopathological features, including Gleason score and extraprostatic extension of tumor; however, most studies fail to demonstrate this to have prognostic significance on multivariate analysis. Consensus was reached with regard to the reporting of some quantitative measure of the volume of tumor in a prostatectomy specimen, without prescribing a specific methodology. Incorporation of the zonal and/or anterior location of the dominant/index tumor in the pathology report was accepted by most participants, but a formal definition of the identifying features of the dominant/index tumor remained undecided.
authors.affiliation: Department of Pathology, University Health Network and University of Toronto, Toronto, ON, Canada. theo.vdkwast@uhn.on.ca
authors.forename: Theo H
authors.initials: TH
authors.lastname: van der Kwast
authors.forename: Mahul B
authors.initials: MB
authors.lastname: Amin
authors.forename: Athanase
authors.initials: A
authors.lastname: Billis
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
authors.forename: David
authors.initials: D
authors.lastname: Griffiths
authors.forename: Peter A
authors.initials: PA
authors.lastname: Humphrey
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Wheeler
authors.forename: John R
authors.initials: JR
authors.lastname: Srigley
authors.forename: Lars
authors.initials: L
authors.lastname: Egevad
authors.forename: Brett
authors.initials: B
authors.lastname: Delahunt
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D038622:Internationality; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D011468:Prostatectomy / Q000379:methods* / Q000592:standards; D011471:Prostatic Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D012955:Societies, Medical; D013048:Specimen Handling