Tumour necrosis factor-alpha polymorphisms and hepatocellular carcinoma: a meta-analysis.
The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. To summarize the quantitative association between polymorphisms of the tumour necrosis factor-alpha (TNFA) gene and HCC, a meta-analysis of relevant studies was performed. Ten case-control studies involving 1421 HCC cases were identified from the Medline, Embase and Current Contents databases. Combined results based on all studies showed that patients with HCC had a significantly lower frequency of the TNFA gene polymorphism -308GG than healthy controls. When stratifying for race, results were similar among Asians and Caucasians. When comparing with hepatitis B virus infection cases, no statistical association was found. This meta-analysis suggests that TNFA -308GG gene polymorphism is associated with a modest decrease in the risk of HCC.
Qin
H
H
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Liu
B
B
Shi
T
T
Liu
Y
Y
Sun
Y
Y
Ma
Y
Y
D044466:Asian People / Q000208:ethnology; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics*; D016206:Databases, Bibliographic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000208:ethnology
D014409:Tumor Necrosis Factor-alpha