Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles.
Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient.
La Marca
A
A
Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, 41100 Modena, Italy. antlamarca@libero.it
Sighinolfi
G
G
Giulini
S
S
Traglia
M
M
Argento
C
C
Sala
C
C
Masciullo
C
C
Volpe
A
A
Toniolo
D
D
D000293:Adolescent; D000328:Adult; D000375:Aging; D054304:Anti-Mullerian Hormone / Q000097:blood*; D003276:Contraceptives, Oral / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D008875:Middle Aged; D012016:Reference Values; D044465:White People
D003276:Contraceptives, Oral; D054304:Anti-Mullerian Hormone