title: Prediction of preeclampsia and delivery of small for gestational age babies based on a combination of clinical risk factors in high-risk women.
abstract: OBJECTIVE
  To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women.
  
  
  METHODS
  Individual risk scores based on clinical risk factors were calculated using logistic regression and validated in 1687 women with obesity in first pregnancy, chronic hypertension, or previous preeclampsia.
  
  
  RESULTS
  The risk of preeclampsia varied from 7% in obese primiparae without hypertension to 30% when previous preeclampsia and chronic hypertension occurred together. A prediction model incorporating these risk factors had a sensitivity of 48 and 89% for preeclampsia delivered <34 weeks' gestation.
  
  
  CONCLUSIONS
  Multiple clinical risk factors increase the risk of preeclampsia and SGA.
authors.affiliation: Division of Reproduction and Endocrinology, St Thomas' Hospital, King's College London, London, UK. paul.seed@kcl.ac.uk
authors.forename: Paul T
authors.initials: PT
authors.lastname: Seed
authors.forename: Lucy C
authors.initials: LC
authors.lastname: Chappell
authors.forename: Michael A
authors.initials: MA
authors.lastname: Black
authors.forename: Katrina K
authors.initials: KK
authors.lastname: Poppe
authors.forename: Yuan-Chun
authors.initials: YC
authors.lastname: Hwang
authors.forename: Nikola
authors.initials: N
authors.lastname: Kasabov
authors.forename: Lesley
authors.initials: L
authors.lastname: McCowan
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Shennan
authors.forename: Steven H
authors.initials: SH
authors.lastname: Wu
authors.forename: Lucilla
authors.initials: L
authors.lastname: Poston
authors.forename: Robyn A
authors.initials: RA
authors.lastname: North
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D005260:Female; D005544:Forecasting; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011225:Pre-Eclampsia / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D018570:Risk Assessment; D012307:Risk Factors; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014810:Vitamin E; D001205:Ascorbic Acid