title: Update on the mechanisms of gastric acid secretion.
abstract: Acid-related disorders represent a major healthcare concern. In recent years, our understanding of the physiologic processes underlying gastric acid secretion has improved notably. The identity of several apical ion transport proteins, which are necessary for acid secretion to take place, has been resolved. The recent developments have uncovered potential therapeutic targets for the treatment of acid-related disorders. This brief review provides an update on the mechanisms of gastric acid secretion, with a particular focus on apical ion transport.
authors.affiliation: Departments of Surgery and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Sascha
authors.initials: S
authors.lastname: Kopic
authors.forename: John P
authors.initials: JP
authors.lastname: Geibel
mesh_terms: D000818:Animals; D002712:Chlorides / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase / Q000502:physiology*; D006632:Histamine / Q000502:physiology; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000502:physiology; D026901:Membrane Transport Proteins / Q000502:physiology; D010295:Parietal Cells, Gastric / Q000502:physiology; D054328:Proton Pump Inhibitors / Q000494:pharmacology; D044169:Receptors, Calcium-Sensing / Q000502:physiology
chemical_list: D002712:Chlorides; D051657:KCNQ1 Potassium Channel; D026901:Membrane Transport Proteins; D054328:Proton Pump Inhibitors; D044169:Receptors, Calcium-Sensing; D006632:Histamine; D017506:H(+)-K(+)-Exchanging ATPase
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