title: Associations between retinal nerve fiber layer abnormalities and optic nerve examination.
abstract: OBJECTIVE
  Retinal nerve fiber layer (RNFL) abnormalities detected by optical coherence tomography (OCT) are useful markers for axonal loss and visual dysfunction in multiple sclerosis (MS), but their role in routine clinical management is not well-studied.
  
  
  METHODS
  Clinical and OCT examinations were performed on 240 patients attending a neurology clinic. Using OCT 5th percentile to define abnormal RNFL thickness, we compared eyes classified by neurologists as having optic atrophy to RNFL thickness, and afferent pupillary defect (APD) to RNFL thickness ratios of eye pairs.
  
  
  RESULTS
  Mean RNFL thickness was less in eyes classified by neurologists as having optic atrophy (79.4 ± 21 μm; n=63) vs those without (97.0 ± 15 μm; n=417; p < 0.001, t test) and in eyes with an APD (84.1 ± 16 μm; n=44) than without an APD (95.8 ± 17 μm; n=436; p < 0.001). Physicians' diagnostic accuracy for detecting pallor in eyes with an abnormal RNFL thickness was 79% (sensitivity=0.56; specificity=0.82). Accuracy for detecting a RAPD in patients with mean RNFL ratio (affected eye to unaffected eye) <0.90 was 73% (sensitivity=0.30; specificity=0.86). Ability to detect visual pathway injury via assessment of atrophy and APD differed between neurologists.
  
  
  CONCLUSIONS
  OCT reveals RNFL abnormality in many patients in whom eyes are not classified by neurologic examiners as having optic atrophy. Further study is needed to define the role of OCT measures in the context of examinations for optic atrophy and APD by neuroophthalmologists. OCT-measured RNFL thickness is likely to have an important future role in the clinical setting.
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: D
authors.initials: D
authors.lastname: Cettomai
authors.forename: G
authors.initials: G
authors.lastname: Hiremath
authors.forename: J
authors.initials: J
authors.lastname: Ratchford
authors.forename: A
authors.initials: A
authors.lastname: Venkatesan
authors.forename: B M
authors.initials: BM
authors.lastname: Greenberg
authors.forename: J
authors.initials: J
authors.lastname: McGready
authors.forename: C A
authors.initials: CA
authors.lastname: Pardo
authors.forename: D A
authors.initials: DA
authors.lastname: Kerr
authors.forename: E
authors.initials: E
authors.lastname: Frohman
authors.forename: L J
authors.initials: LJ
authors.lastname: Balcer
authors.forename: J C
authors.initials: JC
authors.lastname: McArthur
authors.forename: P A
authors.initials: PA
authors.lastname: Calabresi
mesh_terms: D000328:Adult; D005123:Eye / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D011237:Predictive Value of Tests; D011681:Pupil Disorders / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014786:Vision Disorders
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