title: Difference in the effects of tandospirone on ataxia in various types of spinocerebellar degeneration: an open-label study.
abstract: The aim of this study was to investigate the effects of tandospirone on ataxia in various types of spinocerebellar degeneration (SCD). Fifteen milligram per day of tandospirone was administered to 39 patients with SCD (spinocerebellar atrophy (SCA) 1, five patients; SCA2, six patients; Machado-Joseph disease (MJD), 14 patient; SCA6, five patients; multiple system atrophy-cerebellar type (MSA-C), seven patients; and multiple system atrophy-Parkinson type (MSA-P), two patients). All patients were assessed before and 4 weeks after administration of the drug using the international cooperative ataxia rating scale total score (ARS), total length traveled (TLT) of body stabilometry, and a self-rating depression scale. Statistically, ARS showed a significant difference in MJD (p = 0.005) and SCA6 (p = 0.043). TLT also showed a significant difference in MJD (p = 0.002) and SCA6 (p = 0.043). Eight of 39 patients (SCA1, 1/5; SCA2, 0/6; MJD, 4/14; SCA6, 3/5; MSA-C, 0/7; and MSA-P, 0/2) showed more than a five point reduction in ARS, and 13 of 39 patients (SCA1, 0/5; SCA2, 1/6; MJD, 8/14; SCA6, 4/5; MSA-C, 0/7; and MSA-P, 0/2) showed a reduction of TLT. Our data indicate that the effects of tandospirone on ataxia are different between types of SCD. Therefore, tandospirone is useful for cerebellar ataxia in patients with MJD and SCA6.
authors.affiliation: Hokuyukai Neurology Hospital, Niju-yon-ken 2-2-4-30, Nishi-ku, Sapporo, 063-0802, Japan. atakei@med.hokudai.ac.jp
authors.forename: Asako
authors.initials: A
authors.lastname: Takei
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hamada
authors.forename: Sanae
authors.initials: S
authors.lastname: Homma
authors.forename: Keiko
authors.initials: K
authors.lastname: Hamada
authors.forename: Kunio
authors.initials: K
authors.lastname: Tashiro
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hamada
mesh_terms: D000328:Adult; D000368:Aged; D001259:Ataxia / Q000188:drug therapy* / Q000209:etiology*; D003863:Depression / Q000139:chemically induced; D005260:Female; D006801:Humans; D054833:Isoindoles / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D013132:Spinocerebellar Degenerations / Q000145:classification / Q000150:complications*
chemical_list: D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; C055267:tandospirone
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