Using expression genetics to study the neurobiology of ethanol and alcoholism.
Recent simultaneous progress in human and animal model genetics and the advent of microarray whole genome expression profiling have produced prodigious data sets on genetic loci, potential candidate genes, and differential gene expression related to alcoholism and ethanol behaviors. Validated target genes or gene networks functioning in alcoholism are still of meager proportions. Genetical genomics, which combines genetic analysis of both traditional phenotypes and whole genome expression data, offers a potential methodology for characterizing brain gene networks functioning in alcoholism. This chapter will describe concepts, approaches, and recent findings in the field of genetical genomics as it applies to alcohol research.
Farris
Sean P
SP
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Wolen
Aaron R
AR
Miles
Michael F
MF
D000437:Alcoholism / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology; D020869:Gene Expression Profiling / Q000379:methods; D055106:Genome-Wide Association Study; D006801:Humans; D009446:Neurobiology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods
D000431:Ethanol
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