Pathological analysis of umbilical cord ulceration associated with fetal duodenal and jejunal atresia.
Umbilical cord ulceration is a serious complication of fetal intestinal atresia. To elucidate the relationship between fetal intestinal atresia and umbilical cord ulceration grade, we pathologically examined umbilical cords in 15 duodenal and 5 jejunal atresia cases and 28 control cases. Microscopic examination of the umbilical cords of patients with intestinal atresia revealed high-grade ulceration and a significant increase in macrophage numbers (P = 0.0087). Transudation of red blood cells was not associated with any specific clinical diagnosis, but was seen in all high-grade ulceration cases. It is suggested that clinical symptoms become apparent following gradual pathological changes.
Ichinose
M
M
Department of Obstetrics and Gynecology, Japan Red Cross Medical Center, Tokyo, Japan. mamaichinose-tky@umin.ac.jp
Takemura
T
T
Andoh
K
K
Sugimoto
M
M
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002452:Cell Count; D003238:Connective Tissue / Q000473:pathology; D004380:Duodenal Obstruction / Q000151:congenital / Q000473:pathology; D004912:Erythrocytes; D005122:Exudates and Transudates; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000276:immunology / Q000473:pathology; D007583:Jejunum / Q000002:abnormalities; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D012720:Severity of Illness Index; D014456:Ulcer / Q000276:immunology / Q000473:pathology; D014470:Umbilical Cord / Q000002:abnormalities / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule