[The state of cyclic nucleotide system and morphofunctional changes of lung and heart tissues in hypoxia of different genesis].
It was investigated the intercommunication of the functional state of cyclic nucleotides (CN) system and morphofunctional states of lung and heart tissues and influence on these state of lipid peroxidation processes and adenylate cyclase system activity under development in organism of the hypoxic states of different genesis. Obtained dates testify that with the changes of cAMP and cGMP concentrations, and also with their ratio the level of hyperhydratation of air-blood and blood-tissue barriers under the used influence on the organism are closely correlated. Intercommunication of the cyclic nucleotides system functioning and tissues oxygen consumption at the used influences carries sufficiently difficult and ambiguous character. It was shown that exactly at blood loss in lung and heart tissues there were the parallel diminishing of concentrations both cAMP and cGMP. It is accepted to correlate with a favorable histological dynamics. Exactly under these conditions the correlation of CN concentrations is possible to consider balanced and sent to limitation of displays of unfavorable influence of blood loss on investigated tissues ultrastructure. So, there is a tissue specific and depending from the type of influence on the organism character of intercommunication of the functional state of cyclic nucleotides system and morphofunctional states of lung and heart tissues.
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D000222:Adaptation, Physiological; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006470:Hemorrhage / Q000150:complications*; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000502:physiology; D008168:Lung / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP