title: Dabigatran inhibits Staphylococcus aureus coagulase activity.
abstract: The ability of Staphylococcus aureus to clot plasma through conformational activation of prothrombin by staphylocoagulase is used to distinguish S. aureus from coagulase-negative staphylococci. We show that while the direct thrombin inhibitor dabigatran inhibits staphylocoagulase activity, the clinical use of dabigatran etexilate is not expected to interfere with direct tube coagulase testing.
authors.affiliation: Center for Molecular and Vascular Biology, University of Leuven, B-3000 Leuven, Belgium. thomas.vanassche@med.kuleuven.be
authors.forename: Thomas
authors.initials: T
authors.lastname: Vanassche
authors.forename: Jan
authors.initials: J
authors.lastname: Verhaegen
authors.forename: Willy E
authors.initials: WE
authors.lastname: Peetermans
authors.forename: Marc F
authors.initials: MF
authors.lastname: Hoylaerts
authors.forename: Peter
authors.initials: P
authors.lastname: Verhamme
mesh_terms: D001562:Benzimidazoles / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D003030:Coagulase / Q000037:antagonists & inhibitors*; D000069604:Dabigatran; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D013211:Staphylococcus aureus / Q000201:enzymology*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D001562:Benzimidazoles; D003030:Coagulase; D004791:Enzyme Inhibitors; D015091:beta-Alanine; D000069604:Dabigatran
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