title: Peripartum serum leptin and soluble leptin receptor levels in women with gestational diabetes.
abstract: The purpose of the study was to clarify the alterations in serum leptin and soluble leptin receptor levels at term and early postpartum in gestational diabetes mellitus (GDM). Twenty women with normal pregnancy and 20 with GDM were recruited and blood samples were taken on the day of delivery and Days 1, 3 and 5 after delivery. Serum leptin levels were significantly higher in women with GDM than in the controls before delivery and decreased significantly after delivery (p < 0.001). After delivery there were no significant differences in serum leptin concentrations between women with GDM and the controls. Serum soluble leptin receptor concentrations did not differ neither between the two groups, nor before or after delivery. Leptin may play a role in GDM through a positive correlation with insulin resistance.
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Danqing
authors.initials: D
authors.lastname: Chen
authors.forename: Guiyu
authors.initials: G
authors.lastname: Xia
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Minyue
authors.initials: M
authors.lastname: Dong
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D020738:Leptin / Q000097:blood*; D058725:Peripartum Period / Q000097:blood*; D011247:Pregnancy; D054411:Receptors, Leptin / Q000097:blood*; D012016:Reference Values; D012680:Sensitivity and Specificity; D012995:Solubility; D047929:Term Birth; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020738:Leptin; D054411:Receptors, Leptin