title: Chaetoglocins A-D, four new metabolites from the endophytic fungus Chaetomium globosum.
abstract: Chaetoglocins A-D (1- 4), four new secondary metabolites, were isolated from the solid-fermentation culture of Chaetomium globosum (strain no. IFB-E036), an endophytic fungus residing inside the root of Cynodon dactylon. The structures of these compounds were elucidated on the basis of detailed spectroscopic evidence and by comparing spectroscopic data with those in the literature. Compounds 1 and 2 displayed antimicrobial activity against the gram-positive bacteria with minimum inhibitory concentrations (MIC) between 8 and 32 µg/mL.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, P. R. China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Su Hai
authors.initials: SH
authors.lastname: Xu
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Yong Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Wu Yang
authors.initials: WY
authors.lastname: Huang
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D031744:Cynodon; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D038821:Mycorrhizae / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products