[Role of CD69 in the pathogenesis of inflammation].
CD69 is a type II membrane protein expressed as a homodimer composed of heavily glycosylated subunits. CD69 is known as an early activation marker antigen of lymphocytes,and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In order to address the role of CD69 in the pathogenesis of arthritis and allergic airway inflammation, we established CD69-deficient mice. CD69-deficient mice displayed a markedly attenuated arthritic inflammatory response and airway inflammation. The administration of anti-CD69 antibody inhibited the induction of the antigen-induced airway inflammation and hyperresponsiveness. These results indicate that CD69 plays a crucial role in the pathogenesis of arthritis and allergic airway inflammation and that CD69 could be a possible therapeutic target for arthritis and asthma in human patients.
Hasegawa
Akihiro
A
Department of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University.
Nakayama
Toshinori
T
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D001168:Arthritis / Q000209:etiology; D001249:Asthma / Q000209:etiology; D007249:Inflammation / Q000209:etiology*; D037181:Lectins, C-Type / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D037181:Lectins, C-Type; D000099192:CD69 Antigens