title: In-hospital mortality of disseminated tuberculosis in patients infected with the human immunodeficiency virus.
abstract: BACKGROUND
  Tuberculosis (TB) is a cause of significant morbidity and mortality in patients with AIDS. The goal of our study was to determine predictors of in-hospital mortality in patients with AIDS and disseminated tuberculosis in a middle-income country.
  
  
  METHODS
  We conducted a retrospective cohort study in a tertiary care center, for patients with AIDS in southern Brazil. From 1996 to 2008, all patients with the diagnosis of disseminated TB were included.
  
  
  RESULTS
  Eighty patients were included. In-hospital mortality was 35% (N = 28). On multivariate Cox regression analysis, low basal albumin (P < .01) was associated with death, and fever at admission was related to better survival (P < .01).
  
  
  CONCLUSIONS
  Albumin levels or fever are independent predictors of survival in patients with HIV and disseminated TB. They can serve as indirect markers of immunodeficiency in patients with disseminated TB and AIDS.
authors.affiliation: Infectious Disease Service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Rodrigo Pires
authors.initials: RP
authors.lastname: dos Santos
authors.forename: Caroline
authors.initials: C
authors.lastname: Deutschendorf
authors.forename: Karin
authors.initials: K
authors.lastname: Scheid
authors.forename: Luciano Zubaran
authors.initials: LZ
authors.lastname: Goldani
mesh_terms: D000418:Albumins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001938:Brazil; D018450:Disease Progression; D005260:Female; D005334:Fever; D006678:HIV / Q000276:immunology* / Q000472:pathogenicity; D015658:HIV Infections / Q000150:complications / Q000401:mortality* / Q000473:pathology / Q000503:physiopathology; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014376:Tuberculosis / Q000150:complications / Q000401:mortality* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000418:Albumins; D015415:Biomarkers
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