title: [New alkyl cationic glycerolipids with heterocyclic polar domain are responsible for disorders in the leukemia cells cycle and cells apoptosis].
abstract: A series of new modifications of alkyl cationic glycerolipids with hetero polar domain has been synthesized. The most active compound rac-N-(4-[(2-ethoxy-3-octadecyloxy)prop-1-yloxycarbonyl]butyl)-N'-etylimidazoliyiodid in micromolar concentrations causes a delay of cell cycle in phase G1, DNA fragmentation and apoptosis of cell line leukemia.
authors.forename: A A
authors.initials: AA
authors.lastname: Markova
authors.forename: N V
authors.initials: NV
authors.lastname: Pliavnik
authors.forename: V V
authors.initials: VV
authors.lastname: Tatarskiĭ
authors.forename: A A
authors.initials: AA
authors.lastname: Shtil'
authors.forename: G A
authors.initials: GA
authors.lastname: Serebrennikova
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects*; D016193:G1 Phase / Q000187:drug effects*; D005989:Glycerides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D005989:Glycerides; D006571:Heterocyclic Compounds