title: Human metapneumovirus genotypes and severity of disease in young children (n = 100) during a 7-year study in Dijon hospital, France.
abstract: Human metapneumovirus is a cause of respiratory tract infections at all ages. Our objectives were to analyze the distribution of the A and B genotypes over 7 years in Dijon and to investigate a possible association between hMPV genotypes and disease severity. During 2002-2009, we genotyped the 100 isolates from children <3 years old with hMPV. Phylogenetic analysis indicated a change in the distribution of hMPV genotype over the years. Severity was then measured by detailed clinical evaluation. The hospitalization rate was greater when genotype B was involved 72.5% versus 53.3% (P = 0.054). Those infected with genotype B tended to have a higher clinical score, as measured by Vicente et al. 2006 (P = 0.07). We showed that, although clinical severity is not clearly associated with hMPV genotype in this study, pathological signs on chest X-ray were observed more often in B subgroup (P < 0.01).
authors.affiliation: Laboratoire de Virologie, Centre Hospitalier Universitaire, Dijon, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Pitoiset
authors.forename: Magali
authors.initials: M
authors.lastname: Darniot
authors.forename: Frédéric
authors.initials: F
authors.lastname: Huet
authors.forename: Serge-Ludwig
authors.initials: SL
authors.lastname: Aho
authors.forename: Pierre
authors.initials: P
authors.lastname: Pothier
authors.forename: Catherine
authors.initials: C
authors.lastname: Manoha
mesh_terms: D016000:Cluster Analysis; D005260:Female; D005602:France; D005838:Genotype; D006760:Hospitalization / Q000706:statistics & numerical data; D006761:Hospitals; D006801:Humans; D007223:Infant; D008297:Male; D029121:Metapneumovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D018184:Paramyxoviridae Infections / Q000473:pathology* / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D013902:Radiography, Thoracic; D012141:Respiratory Tract Infections / Q000473:pathology* / Q000821:virology*; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index
chemical_list: D012367:RNA, Viral
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