Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning.
Sweet solutions are commonly used in animal research to deliver drugs to test for addictive capacity and efficacy. In this study we compared the effects of a range of sucrose and saccharin concentrations on the performance of an operant assay. Our findings demonstrate that across a range of sucrose solutions some produce a success ratio which could mistakenly be labeled allodynic demonstrating the importance of choosing the correct reward solution.
Nolan
Todd A
TA
Center for Comprehensive Pain Research, University of Florida, Gainesville, FL, United States.
Caudle
Robert M
RM
Neubert
John K
JK
D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced*; D008297:Male; D009753:Nutritive Value; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D054772:Rats, Hairless; D017207:Rats, Sprague-Dawley; D012201:Reward; D012439:Saccharin / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013395:Sucrose / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology*; D013697:Thermosensing / Q000187:drug effects
D013549:Sweetening Agents; D013395:Sucrose; D012439:Saccharin
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