Effect of dihydrocapsiate on resting metabolic rate in humans.
BACKGROUND
Dihydrocapsiate is a capsinoid found in chili peppers. Dihydrocapsiate is similar to capsaicin, which is known for its thermogenic properties.


OBJECTIVE
The objective was to determine the acute and chronic effect of dihydrocapsiate on resting metabolic rate (RMR).


METHODS
Seventy-eight healthy subjects in a double-blind, parallel-arm trial were randomly assigned to 3 groups receiving 0 (placebo), 3, or 9 mg dihydrocapsiate/d for 28 d. After a 10-h overnight fast, RMR was measured by indirect calorimetry for 30 min before and 120 min after ingestion of dihydrocapsiate.


RESULTS
RMR was similar in the 3 groups before dosing on day 1 [1714 ± 41 kcal/d (0 mg), 1760 ± 41 kcal/d (3 mg), and 1694 ± 38 kcal/d (9 mg)] and after acute dosing (41 ± 17, 55 ± 17, and 3 ± 24 kcal/d for 3-mg, 9-mg, and placebo groups, respectively). When the chronic effect of dihydrocapsiate on RMR was calculated from the average 2-h RMR on day 28 minus the 30-min preingestion RMR at baseline, a borderline effect in subjects receiving 3 mg dihydrocapsiate/d compared with placebo was observed (61 ± 24 kcal/d compared with -1 ± 12 kcal/d, P = 0.054), whereas no significant increase in RMR in comparison with placebo was noted for the 9-mg/d dose (48 ± 23 kcal/d compared with -1 ± 12 kcal/d, P = 0.12). When data from both groups were combined, the thermic effect of dihydrocapsiate reached significance (53 ± 9 kcal/d compared with -1 ± 12 kcal/d in the placebo group, P = 0.04). Fat oxidation was unaffected by dihydrocapsiate.


CONCLUSIONS
After 1 mo of supplementation, dihydrocapsiate had a small thermogenic effect of ≈50 kcal/d, which is in the range of day-to-day RMR variability. This trial was registered at clinicaltrials.gov as NCT00999297.
Galgani
Jose E
JE
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Ravussin
Eric
E
D000328:Adult; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001481:Basal Metabolism / Q000187:drug effects*; D002211:Capsaicin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002212:Capsicum / Q000737:chemistry*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D012016:Reference Values; D022722:Thermogenesis / Q000187:drug effects*
D019440:Anti-Obesity Agents; D010936:Plant Extracts; D002211:Capsaicin
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