title: The effect of oral clonidine premedication on nausea and vomiting after ear surgery.
abstract: OBJECTIVE
  Postoperative nausea and vomiting (PONV) is a most distressing adverse event for surgical patients with a considerable economic impact .The aim of the present study was to evaluate the effect of clonidine given orally for PONV in patients undergoing anesthesia for outpatient ear surgery.
  
  
  METHODS
  Sixty patients 30.2 +/- 9.9 years, scheduled for ear surgery, were randomly assigned to one of two groups (clonidine or placebo) in a double-blinded manner. Anesthesia was standardized laryngeal mask airway, fentanyl, propofol, halothane, nitrous oxide.
  
  
  RESULTS
  A complete response, defined as no PONV and no need for rescue antiemetic medication, during the first 24 h after anesthesia was 33% with placebo and 67% with clonidine, respectively (P. 0.01). No clinically adverse event was observed in any of the groups.
  
  
  CONCLUSIONS
  Oral premedication with clonidine reduced the rate of PONV in patients undergoing outpatient ear surgery.
authors.affiliation: Tehran University of Medical Sciences, Amir Alam Hospital, Tehran, Iran. taheria@sina.tums.ac.ir
authors.forename: Arman
authors.initials: A
authors.lastname: Taheri
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Javadimanesh
authors.forename: Haleh
authors.initials: H
authors.lastname: Ashraf
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003000:Clonidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004423:Ear / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies
chemical_list: D003000:Clonidine