title: Cyclooxygenase-2 network as predictive molecular marker for clinical pregnancy in in vitro fertilization.
abstract: The gene expression of human endometrium on the day of oocyte retrieval of pregnant and nonpregnant patients in a stimulated IVF cycle was compared in two independent groups with different GnRH-antagonist ovarian stimulation protocols. The present data suggest that increased gene expression of cyclooxygenase-2, together with the expression of other molecules in the cyclooxygenase-2 network, on the day of oocyte retrieval in GnRH-antagonist cycles coincides with a lower probability of achieving a clinical pregnancy in this cycle.
authors.affiliation: Department of Pathology, Vrije Universiteit Brussel and UZ Brussel, Jette, Belgium. ivvaeren@vub.ac.be
authors.forename: Inge
authors.initials: I
authors.lastname: Van Vaerenbergh
authors.forename: Christophe
authors.initials: C
authors.lastname: Blockeel
authors.forename: Leentje
authors.initials: L
authors.lastname: Van Lommel
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ghislain
authors.forename: Peter
authors.initials: P
authors.lastname: In't Veld
authors.forename: Frans
authors.initials: F
authors.lastname: Schuit
authors.forename: Human Mousavi
authors.initials: HM
authors.lastname: Fatemi
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
authors.forename: Claire
authors.initials: C
authors.lastname: Bourgain
mesh_terms: D015415:Biomarkers; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D004717:Endometrium / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D015415:Biomarkers; D051546:Cyclooxygenase 2