Rotenoids from Lablab purpureus L. and their bioefficacy against human disease vectors.
Various plant parts of Lablab purpureu s L. were collected and analyzed separately for their rotenoid content. Among the plant parts, the maximum content was in the roots and minimum in the seeds. The identity of different rotenoids was confirmed by melting point, mixed melting point, UV, and infrared spectral studies and gas-liquid chromatography. Six rotenoids (deguelin, dehydrodeguelin, rotenol, rotenone, tephrosin, and sumatrol) were isolated, identified, and quantified both in vivo and in vitro. Toxicological studies of extracts showed bioefficacy against causal agents of malaria, dracunculiasis, and amoebiasis.
Kamal
Raka
R
Laboratory of Medicinal Plant Biotechnology, Department of Botany and Biotechnology, University of Rajasthan, Jaipur, 302004, India. rakakamal@hotmail.com
Mathur
N
N
D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D033342:Copepoda / Q000187:drug effects*; D004748:Entamoeba histolytica / Q000187:drug effects*; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012402:Rotenone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
D000981:Antiprotozoal Agents; D007306:Insecticides; D010936:Plant Extracts; D012402:Rotenone
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