The clinical-basic interface in defining pathogenesis in disorders of neurodevelopmental origin.
Human cognitive and social-emotional behaviors are heterogeneous, underscoring the challenges in modeling pathogenesis in disorders of neurodevelopmental origin in which these domains are dysfunctional. In general, animal models for these disorders are built to emulate our understanding of the clinical diagnosis, with mixed results. We suggest the utility of model systems lies in the use of different strategies to perturb hierarchical circuit development, to examine the behavioral dimensions that are most impacted, and to discern the capacity for, and heterogeneity of, neuroadaptation that will then inform treatment strategies.
Thompson
Barbara L
BL
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Levitt
Pat
P
D000818:Animals; D001927:Brain Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology*; D002658:Developmental Disabilities / Q000150:complications / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D004777:Environment; D006801:Humans; D013045:Species Specificity
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