A new strategy for the synthesis of poly-substituted 3-H, 3-fluoro, or 3-trifluoromethyl pyridines via the tandem C-F bond cleavage protocol.
A new strategy for the synthesis of poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines based on C-F bond breaking of the anionically activated fluoroalkyl group is described. A series of 2,6-disubstituted 4-amino pyridines were prepared through this domino process in high yields under noble metal-free conditions, making this method a supplement to pyridine synthesis.
Chen
Zixian
Z
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Zhu
Jiangtao
J
Xie
Haibo
H
Li
Shan
S
Wu
Yongming
Y
Gong
Yuefa
Y
D002244:Carbon / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D005461:Fluorine / Q000737:chemistry*; D017611:Fluorine Compounds / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis*
D017611:Fluorine Compounds; D011725:Pyridines; C407065:trifluoromethylpyridine; D005461:Fluorine; D002244:Carbon