title: 3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.
abstract: We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
authors.affiliation: Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
authors.forename: Kung
authors.initials: K
authors.lastname: Ban
authors.forename: Sandra
authors.initials: S
authors.lastname: Duffy
authors.forename: Yelena
authors.initials: Y
authors.lastname: Khakham
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Andrew
authors.initials: A
authors.lastname: Hughes
authors.forename: Oliver
authors.initials: O
authors.lastname: Montagnat
authors.forename: Kasiram
authors.initials: K
authors.lastname: Katneni
authors.forename: Eileen
authors.initials: E
authors.lastname: Ryan
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Baell
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008862:Microsomes, Liver / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects*; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D014227:Triazines; C093444:1,2,4-triazine