Rhabdomyolysis induced by rosuvastatin and sildenafil.
A 66-year-old man with diabetes and hypertension using statin was admitted to the hospital with progressive myalgia. He had been on rosuvastatin for five months. After beginning the use of phosphodiesterase-5 inhibitors, he presented with severe muscle pain and maintained penile erection. Several days after interruption of therapy, muscle pain and penile erection disappeared. This case demonstrates the interaction of sildenafil with rosuvastatin might result in myopathy.
Pennisi
Giovanni
G
Department of Neurosciences, University of Catania, Catania, Italy; and Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy.
Vacante
Marco
M
Russo
Cristina
C
Malaguarnera
Mariano
M
D000368:Aged; D004347:Drug Interactions; D005464:Fluorobenzenes / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D010146:Pain / Q000139:chemically induced; D010410:Penile Erection / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D011687:Purines / Q000009:adverse effects; D011743:Pyrimidines / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D000068718:Rosuvastatin Calcium; D000068677:Sildenafil Citrate; D013449:Sulfonamides / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects*
D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D013449:Sulfonamides; D013450:Sulfones; D000068718:Rosuvastatin Calcium; D000068677:Sildenafil Citrate