Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant.
Splenic rupture (SR) is a rare adverse event observed in patients treated with G-CSF as a peripheral hematopoietic stem cell (PHSC) mobilizing agent, mostly in myeloma multiple and amiloidosis; to date, to our knowledge, it has not been previously described in plasma-cell leukemia (PCL). We report a case of a woman with PCL, who presented a SR after PHSC mobilization with Cyclophosphamide+G-CSF. The spleen removed showed hematopoietic foci and amiloid material. In the course of a second mobilization, 2 months after, the patient died from sepsis. We considered it important to report this case, in order to keep in mind the possibility of SR in patients with malignant gammopathy.
Funes
Consuelo
C
Servicio de Hematología, Hospital V Arrixaca, Murcia, Spain. mariac.funes@carm.es
Garcia-Candel
Faustino
F
Majado
Maria Juliana
MJ
González-García
Consuelo
C
Bas
Agueda
A
Salido
Eduardo
E
Moraleda
Jose M
JM
Morales
Alfonso
A
D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000150:complications*; D008875:Middle Aged; D013161:Splenic Rupture / Q000209:etiology*; D013163:Splenomegaly / Q000139:chemically induced; D014182:Transplantation, Autologous
D016179:Granulocyte Colony-Stimulating Factor