title: Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea.
abstract: To examine whether dietary supplementation with omega-3 fatty acids from Clupeonella grimmi can relieve symptoms of dysmenorrhoea, we carried out a cross-over clinical trial on 36 girls aged 18-22 years. They were randomly allocated into 2 groups of 18. Group A received 15 mL fish oil daily (550 mg eicosapentaenoic acid; 205 mg decosahexaenoic acid) while Group B received placebo. After 3 months, the treatment regimens were swapped. The treatment groups reported a significant difference after 3 months of supplementation with fish oil (visual analogue scale score 20.9 compared with 61.8 for the placebo (P= 0.001). There was also a marked reduction in low back pain and abdominal pain (P < 0.05), and participants needed significantly fewer rescue doses of ibuprofen while using fish oil.
authors.affiliation: Department of Pharmacology, Babol University of Medical Sciences, Babol, islamic Republic of Iran. moghadamnia@yahoo.com
authors.forename: A A
authors.initials: AA
authors.lastname: Moghadamnia
authors.forename: N
authors.initials: N
authors.lastname: Mirhosseini
authors.forename: M Haji
authors.initials: MH
authors.lastname: Abadi
authors.forename: A
authors.initials: A
authors.lastname: Omranirad
authors.forename: S
authors.initials: S
authors.lastname: Omidvar
mesh_terms: D002626:Chemistry, Pharmaceutical; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D015118:Eicosapentaenoic Acid / Q000737:chemistry / Q000627:therapeutic use*; D004655:Emulsions; D005260:Female; D006801:Humans; D007492:Iran; D010147:Pain Measurement; D017060:Patient Satisfaction; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004655:Emulsions; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid