title: No evidence of microbleeds in ALS patients at 7 Tesla MRI.
abstract: There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht. E.Verstraete@umcutrecht.nl
authors.forename: Esther
authors.initials: E
authors.lastname: Verstraete
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Biessels
authors.forename: Martijn P
authors.initials: MP
authors.lastname: van Den Heuvel
authors.forename: Fredy
authors.initials: F
authors.lastname: Visser
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van Den Berg
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D001812:Blood-Brain Barrier / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002560:Cerebrovascular Circulation; D006485:Hemosiderin; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008833:Microcirculation; D008875:Middle Aged
chemical_list: D006485:Hemosiderin