title: High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies.
abstract: We performed a large case-control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin's lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, South Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Kang
authors.forename: Jeong Hyun
authors.initials: JH
authors.lastname: Cho
authors.forename: Cheol Won
authors.initials: CW
authors.lastname: Suh
authors.forename: Dae Ho
authors.initials: DH
authors.lastname: Lee
authors.forename: Heung Bum
authors.initials: HB
authors.lastname: Oh
authors.forename: Yong Hak
authors.initials: YH
authors.lastname: Sohn
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Chan Jeong
authors.initials: CJ
authors.lastname: Park
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Jang
authors.forename: Kyoo Hyung
authors.initials: KH
authors.lastname: Lee
authors.forename: Je-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Young Hwa
authors.initials: YH
authors.lastname: Chung
authors.forename: Tae Hyup
authors.initials: TH
authors.lastname: Kim
authors.forename: Hai-Rim
authors.initials: HR
authors.lastname: Shin
authors.forename: Jooryung
authors.initials: J
authors.lastname: Huh
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000821:virology*; D016174:Hepacivirus / Q000472:pathogenicity; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology*; D006515:Hepatitis B virus / Q000472:pathogenicity; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology