Secondary deuterium isotope effects on the acidity of glycine.
Secondary deuterium isotope effects (IE) on the acidity (pK(a)) of glycine were measured by ¹³C NMR titration. It was found that deuteration decreases the pK(a) by 0.034 ± 0.002. The experimental data are supported by theoretical calculations, which, in turn, allowed to relate the acidity decrease to the lowering of glycine vibrational frequencies upon deuteration.
Romero
Jonathan
J
Department of Chemistry, Universidad Nacional de Colombia, Bogotá, Colombia. jromerof@unal.edu.co
Reyes
Andrés
A
Wist
Julien
J
D003903:Deuterium / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D014732:Vibration
D003903:Deuterium; D005998:Glycine