title: Disruptive effect of amphetamines on Pavlovian to instrumental transfer.
abstract: Reward-seeking behavior can be powerfully modulated by exposure to a conditioned stimulus (CS) that was previously associated with that reward. This can be demonstrated in a Pavlovian to instrumental transfer (PIT) task where presentation of a CS (e.g., tone and light) previously paired with a rewarding unconditioned stimulus (US; e.g., food) leads to increases in a behavioral response, such as a lever press, that was also paired with the same US. The transfer effect can be enhanced in rats by exposing them repeatedly to amphetamine after they have undergone Pavlovian conditioning and instrumental training. However, it is not clear if amphetamine injections given immediately after Pavlovian conditioning, which are predicted to enhance memory consolidation for the CS-US association, would also enhance the transfer effect. We tested this hypothesis by giving male, Sprague-Dawley rats i.p. injections of saline or drug (0.5, 1.0, or 3.0 mg/kg amphetamine or methamphetamine) immediately following Pavlovian conditioning sessions. We found that amphetamine, but not methamphetamine, enhanced Pavlovian approach behavior. During a subsequent PIT test done under extinction conditions, we found that rats given either drug, particularly at the highest dose, exhibited deficits in PIT relative to saline-treated controls. These results suggest that treatment with amphetamines after Pavlovian conditioning sessions, when memory consolidation of the CS-US association is hypothesized to occur, inhibits the ability of the CS to subsequently elicit reward-seeking behavior.
authors.affiliation: Neuroscience Program, University of Illinois, Urbana-Champaign, IL 61820, USA.
authors.forename: Darien A
authors.initials: DA
authors.lastname: Hall
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Gulley
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D014163:Transfer, Psychology / Q000187:drug effects*
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D000661:Amphetamine
references.citation: Am J Psychiatry. 1998 Jan;155(1):124-6
references.pmid: 9433350
references.citation: J Pharmacol Exp Ther. 1997 Aug;282(2):561-73
references.pmid: 9262316
references.citation: J Exp Psychol Anim Behav Process. 1983 Jul;9(3):225-47
references.pmid: 6153052
references.citation: Neuropsychopharmacology. 1996 May;14(5):325-37
references.pmid: 8703301
references.citation: Neurosci Biobehav Rev. 2010 Jul;34(8):1277-95
references.pmid: 20385164
references.citation: BMC Biol. 2006 Apr 13;4:8
references.pmid: 16613600
references.citation: Ann N Y Acad Sci. 2007 May;1104:147-71
references.pmid: 17360797
references.citation: Learn Mem. 2008 Apr 25;15(5):299-303
references.pmid: 18441288
references.citation: Psychopharmacology (Berl). 2003 Feb;165(4):359-69
references.pmid: 12491026
references.citation: J Neurosci. 2001 Nov 15;21(22):9018-26
references.pmid: 11698612
references.citation: Life Sci. 1999;64(9):775-84
references.pmid: 10075110
references.citation: Neurobiol Learn Mem. 2006 Nov;86(3):305-10
references.pmid: 16750404
references.citation: J Pharmacol Exp Ther. 1995 Jul;274(1):90-6
references.pmid: 7616454
references.citation: J Neurosci. 2001 Oct 1;21(19):7831-40
references.pmid: 11567074
references.citation: J Neurosci. 2000 Nov 1;20(21):8122-30
references.pmid: 11050134
references.citation: J Pharmacol Exp Ther. 1973 Oct;187(1):27-33
references.pmid: 4795731
references.citation: Curr Opin Neurobiol. 2004 Apr;14(2):156-62
references.pmid: 15082319
references.citation: Psychopharmacologia. 1974;39(1):57-66
references.pmid: 4138622
references.citation: Psychopharmacology (Berl). 2009 Mar;202(4):699-709
references.pmid: 18850090
references.citation: Psychopharmacology (Berl). 2008 Jan;195(4):469-78
references.pmid: 17874316
references.citation: Learn Mem. 2006 Mar-Apr;13(2):123-6
references.pmid: 16547159
references.citation: Pharmacol Biochem Behav. 1973 Jan-Feb;1(1):67-71
references.pmid: 4204513
references.citation: Neuropharmacology. 2009;56 Suppl 1:186-95
references.pmid: 18708077
references.citation: J Neurosci. 2001 May 1;21(9):3251-60
references.pmid: 11312310
references.citation: Psychopharmacology (Berl). 1981;75(2):134-43
references.pmid: 6798603
references.citation: Eur J Neurosci. 2001 May;13(10):1984-92
references.pmid: 11403692
references.citation: Ann N Y Acad Sci. 2007 May;1104:1-20
references.pmid: 17344542
references.citation: J Neurosci. 1999 Nov 1;19(21):9579-86
references.pmid: 10531460
references.citation: Eur J Neurosci. 2009 Apr;29(7):1461-76
references.pmid: 19309320
references.citation: Neuropsychopharmacology. 2006 Dec;31(12):2716-27
references.pmid: 16971900
references.citation: Eur J Neurosci. 2007 Mar;25(5):1557-67
references.pmid: 17425582
references.citation: Learn Mem. 2008 Jul 14;15(7):483-91
references.pmid: 18626092
references.citation: Neurobiol Learn Mem. 2007 May;87(4):644-58
references.pmid: 17258476
references.citation: Am J Psychiatry. 2000 Nov;157(11):1789-98
references.pmid: 11058476
references.citation: Am J Psychiatry. 2002 Oct;159(10):1642-52
references.pmid: 12359667
references.citation: Eur J Neurosci. 2007 Dec;26(11):3141-9
references.pmid: 18005062
references.citation: Behav Brain Res. 2004 Aug 31;153(2):397-408
references.pmid: 15265635
references.citation: J Neurosci. 2006 Jun 14;26(24):6583-8
references.pmid: 16775146
references.citation: Am J Psychiatry. 1999 Jan;156(1):11-8
references.pmid: 9892292
references.citation: Eur J Neurosci. 2003 Apr;17(8):1680-94
references.pmid: 12752386
references.citation: J Neurosci. 2007 Dec 19;27(51):13977-81
references.pmid: 18094235
references.citation: Learn Mem. 2008 Aug 06;15(8):597-602
references.pmid: 18685151
references.citation: J Exp Psychol. 1948 Apr;38(2):173-7
references.pmid: 18913666
references.citation: J Neurosci. 2005 Jan 26;25(4):962-70
references.pmid: 15673677
references.citation: Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91
references.pmid: 8401595
references.citation: Drug Alcohol Depend. 2008 Sep 1;97(1-2):1-20
references.pmid: 18479844
references.citation: Brain Res. 1992 Feb 7;571(2):330-7
references.pmid: 1377088
references.citation: J Exp Anal Behav. 1994 Mar;61(2):169-80
references.pmid: 7513346
references.citation: Pharmacol Biochem Behav. 2007 Jan;86(1):140-9
references.pmid: 17275894