Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether.
Six novel cleomiscosin A (a coumarino-lignoid), derivatives have been synthesized for the first time by using electrophilic substitution reaction to give nuclear nitrated and halogenated derivatives of cleomiscosin A in good yields. Structures of these compounds were established on the basis of IR, (1)H NMR, (13)C NMR and Mass spectral data. Some of the synthesized derivatives were tested for in-vitro target based anti-inflammatory study using primary macrophages cell culture bioassay system. The results showed that the compounds 1a, 3a and 4a (1 and 10 μg/mL) exhibited potent anti-inflammatory activity.
Sharma
Shelly
S
Process Chemistry and Chemical Engineering Department, Central Institute of Medicinal and Aromatic Plants, (Council of Scientific and Industrial Research), P.O. CIMAP, Lucknow-226015, Uttar Pradesh, India.
Chattopadhyay
S K
SK
Trivedi
Priyanka
P
Bawankule
D U
DU
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004987:Ethers; D005260:Female; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared
D000893:Anti-Inflammatory Agents; D003374:Coumarins; D004987:Ethers; D008024:Ligands; C041934:cleomiscosin A