Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study.
OBJECTIVE
Cell therapy for stress urinary incontinence (SUI) management has been experienced with encouraging results.


METHODS
We conducted an open prospective study on 12 women presenting severe SUI with fixed urethra, after previous failed surgical management. Patients underwent intrasphincteric injections of autologous progenitor muscular cells isolated from a biopsy of deltoid muscle. Primary endpoint focused on safety (measurement of Q(max) variation after 3 months). Secondary endpoints assessed side effects and efficacy.


RESULTS
No variation was diagnosed on Q(max) measurements. Efficacy data show that three of 12 patients are dry at 12 months, seven other patients are improved on pad test but not on voiding diary, and two patients were slightly worsened by the procedure. Quality of life was improved in half of patients.


CONCLUSIONS
Cell therapy for severe multioperated cases of SUI is a mini-invasive, feasible, and safe procedure that can improve urinary condition in as a second line therapy.
Sèbe
Philippe
P
Department of Urology, Tenon Hospital, Groupe Hospitalo-Universitaire EST, Assistance Publique-Hôpitaux de Paris, University Paris VI, 4 rue de la Chine, 75970, Paris Cedex 20, France.
Doucet
Christelle
C
Cornu
Jean-Nicolas
JN
Ciofu
Calin
C
Costa
Pierre
P
de Medina
Sixtina Gil Diez
SG
Pinset
Christian
C
Haab
Francois
F
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D032446:Myoblasts / Q000637:transplantation*; D011446:Prospective Studies; D011788:Quality of Life; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000628:therapy*
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