Fibroblast growth factor (FGF)-21 signals through both FGF receptor-1 and 2.
Fibroblast growth factor (FGF)-21 is a member of the FGF superfamily based on sequence homology. However, unlike most members of this family it does not show any mitogenic activity in all cell types tested. The objective of this study is to identify and characterize receptors for this molecule. Sequencing of the cDNA clones from 3T3-L1 adipocytes indicates that the only isoforms for FGFR-1 and 2 expressed in 3T3-L1 cells are 1IIIc and 2IIIc, respectively, suggesting that FGF-21 regulates glucose metabolism in 3T3-L1 adipocytes through FGFR-1IIIc and FGFR-2IIIc.
Ren
GuiPing
G
College of Life Science, Northeast Agricultural University, Harbin, China.
Yin
JieChao
J
Wang
WenFei
W
Li
Lu
L
Li
DeShan
D
D041721:3T3-L1 Cells; D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D002454:Cell Differentiation; D017931:DNA Primers; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D051379:Mice; D034741:RNA, Small Interfering; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D015398:Signal Transduction
D017931:DNA Primers; D034741:RNA, Small Interfering; D017468:Receptors, Fibroblast Growth Factor; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors