The trafficking of Na(V)1.8.
The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel Na(V)1.8 is selectively expressed in sensory neurons. It has been reported that Na(V)1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropathic [24] pain conditions. Thus Na(V)1.8 has been a promising target to treat chronic pain. Here we discuss the recent advances in the study of trafficking mechanism of Na(V)1.8. These pieces of information are particularly important as such trafficking machinery could be new targets for painkillers.
Swanwick
Richard S
RS
Division of Cell & Molecular Biology, Imperial College London, London SW7 2AZ, UK.
Pristerá
Alessandro
A
Okuse
Kenji
K
D033942:Adaptor Proteins, Vesicular Transport / Q000502:physiology; D000818:Animals; D017306:Annexin A2 / Q000502:physiology; D015815:Cell Adhesion Molecules; D002462:Cell Membrane / Q000378:metabolism; D058966:Contactins / Q000502:physiology; D015232:Dinoprostone / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D051379:Mice; D062559:NAV1.8 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000502:physiology; D021122:Protein Subunits / Q000378:metabolism; D021381:Protein Transport; D009418:S100 Proteins / Q000502:physiology; D015222:Sodium Channels / Q000378:metabolism*; D000099248:S100 Calcium Binding Protein A10
D033942:Adaptor Proteins, Vesicular Transport; D017306:Annexin A2; D015815:Cell Adhesion Molecules; D058966:Contactins; D015232:Dinoprostone; D062559:NAV1.8 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; D021122:Protein Subunits; D009418:S100 Proteins; D015222:Sodium Channels; D000099248:S100 Calcium Binding Protein A10; C545704:Pdzd2 protein, mouse; C568317:SCN10A protein, human; C568318:Scn10a protein, mouse
FEBS Lett. 2004 Jan 30;558(1-3):114-8
14759526
J Biol Chem. 1987 Aug 5;262(22):10663-71
3038891
J Biol Chem. 1990 Aug 25;265(24):14464-8
2143760
EMBO J. 2002 Sep 2;21(17):4439-48
12198146
Eur J Neurosci. 2005 Jul;22(1):39-49
16029194
Biochim Biophys Acta. 1996 Oct 11;1313(3):283-9
8898866
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17190-5
16286649
Mol Cell Neurosci. 2005 Apr;28(4):636-49
15797711
J Cell Biol. 2002 Sep 30;158(7):1251-62
12356869
PLoS One. 2008 Apr 09;3(4):e1961
18398477
Brain Res Mol Brain Res. 2003 Feb 20;110(2):298-304
12591166
Nat Cell Biol. 2009 Aug;11(8):919-21
19648976
Mol Cell Neurosci. 2009 Nov;42(3):219-25
19607921
Neuron. 1999 Mar;22(3):537-48
10197533
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5
17483457
EMBO J. 2001 Nov 1;20(21):5950-61
11689435
Int J Biochem Cell Biol. 2007;39(3):490-6
17194618
Nat Neurosci. 1999 Jun;2(6):541-8
10448219
J Cell Sci. 2008 Oct 1;121(Pt 19):3243-52
18782866
Neuron. 2005 Mar 3;45(5):765-79
15748851
Nat Rev Neurosci. 2004 Oct;5(10):771-81
15378037
Mol Pain. 2009 Mar 25;5:14
19320998
Nat Genet. 2010 Feb;42(2):149-52
20062061
J Cell Biol. 2000 Sep 4;150(5):1113-24
10973999
Traffic. 2006 Feb;7(2):168-81
16420525
Cell Mol Biol (Noisy-le-grand). 2005 Sep 05;51(2):201-14
16171556
Neuropharmacology. 2005 Dec;49(8):1220-7
16182323
Prog Neurobiol. 2005 Jun;76(2):99-125
16099088
J Biol Chem. 1998 Jul 31;273(31):19679-84
9677396
J Neurosci. 2004 Aug 18;24(33):7387-99
15317864
Eur J Neurosci. 2000 Nov;12(11):3985-90
11069594
PLoS One. 2010 Aug 04;5(8):e11931
20694152
Pain. 2009 Mar;142(1-2):13-6
19128880
Science. 2009 Jun 19;324(5934):1536-40
19443737
Neurosci Lett. 2001 Aug 17;309(1):1-4
11489532
EMBO J. 1988 Aug;7(8):2435-42
2973411
Nature. 2002 Jun 6;417(6889):653-6
12050667
Pflugers Arch. 2008 Jan;455(4):575-82
17638009
J Neurosci. 2006 Oct 11;26(41):10499-507
17035534
Cell. 1986 Aug 1;46(3):437-44
2425982
J Biol Chem. 2004 Apr 16;279(16):16044-9
14761957
Neuroscience. 2003;121(2):441-50
14522002
J Neurophysiol. 2006 Jul;96(1):97-108
16598065
Traffic. 2010 Mar;11(3):405-17
20028484
J Pharmacol Exp Ther. 2006 Dec;319(3):1096-103
16966471
J Neurosci. 2001 Oct 1;21(19):7517-25
11567041
Mol Pharmacol. 2005 Jul;68(1):137-44
15805225
EMBO Rep. 2003 Apr;4(4):412-8
12671685
Int J Biochem Cell Biol. 2009 Jul;41(7):1471-81
19401147
J Physiol. 1999 Apr 15;516 ( Pt 2):433-46
10087343
J Neurosci. 2001 May 1;21(9):3063-72
11312291
Pain. 2002 Jan;95(1-2):143-52
11790477