Primary bilateral Burkitt lymphoma of the lactating breast: a case report and review of the literature.
Burkitt lymphoma (BL) is a highly aggressive neoplasm, which frequently affects the ileocecal region in the sporadic form and the jaw in the endemic form; however, the breast is a rare primary site of this tumor. Here we describe a case of primary bilateral breast BL presenting during lactation in a 23-year-old woman. Excisional biopsy of breast masses demonstrated a B-cell lymphoma with a characteristic 'starry sky' pattern highly suggestive of BL. The neoplastic cells strongly expressed CD20 and CD10, and showed proliferative activity as measured by Ki-67. An IGH-MYC gene fusion indicating the presence of a typical Burkitt translocation t(8;14)(q24;q32) in the tumor tissue was detected by fluorescent in situ hybridization. The present case, along with a comprehensive review of the literature, demonstrates that BL of the breast should be considered in the differential diagnosis of lesions of the breast during lactation. Whether hormonal or antigenic factors trigger Burkitt lymphomagenesis in the lactating breast warrants further investigation.
Negahban
Shahrzad
S
Institute of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran.
Ahmadi
Nasrollah
N
Oryan
Ahmad
A
Khojasteh
Habib N
HN
Aledavood
Azita
A
Soleimanpour
Hossein
H
Mohammadianpanah
Mohammad
M
Oschlies
Ilske
I
Gesk
Stefan
S
Siebert
Reiner
R
Daneshbod
Khosrow
K
Daneshbod
Yahya
Y
D018951:Antigens, CD20 / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D002051:Burkitt Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D007774:Lactation; D007775:Lactation Disorders / Q000175:diagnosis*; D015260:Neprilysin / Q000032:analysis; D050596:Oncogene Fusion / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics; D055815:Young Adult
D018951:Antigens, CD20; D019394:Ki-67 Antigen; D016271:Proto-Oncogene Proteins c-myc; D015260:Neprilysin
Am J Dis Child. 1975 Oct;129(10):1219-23
1190147
J Pediatr Hematol Oncol. 2010 Mar;32(2):e75-8
20168249
Cancer. 1972 Jun;29(6):1705-12
4555557
Clin Imaging. 2001 Sep-Oct;25(5):309-11
11682286
Cancer. 2007 Jul 1;110(1):25-30
17541937
Jpn J Clin Oncol. 2003 Aug;33(8):399-403
14523060
Cancer. 1977 May;39(5):2033-40
322851
Breast Cancer. 2005;12(3):234-7
16110296
Arch Gynecol Obstet. 2009 Aug;280(2):297-300
19107501
JAMA. 1977 Jan 10;237(2):151
318712
Med Oncol. 2000 Aug;17(3):233-6
10962537
Dtsch Med Wochenschr. 1980 Mar 21;105(12):413-7
7363786
West Afr J Med. 2005 Jul-Sep;24(3):280-2
16276714
Obstet Gynecol. 1980 Oct;56(4):533-6
7422203
Clin Imaging. 2006 Jan-Feb;30(1):57-9
16377487
Br J Surg. 1967 Sep;54(9):776-80
6047810
Breast J. 2006 Mar-Apr;12(2):177-8
16509847
Gan No Rinsho. 1986 Aug;32(9):1023-7
3528559
Cancer. 1989 Apr 15;63(8):1624
2924269
Arch Gynecol Obstet. 2009 May;279(5):743-6
18797899
AJR Am J Roentgenol. 2006 Apr;186(4):1029-32
16554574
Blood. 2008 Sep 15;112(6):2248-60
18612102
Cancer. 1987 Dec 15;60(12):3033-41
3315180
Diagn Cytopathol. 2002 Jul;27(1):60-2
12112818
Ann Diagn Pathol. 2006 Jun;10(3):144-8
16730308
Conn Med. 1995 Nov;59(11):651-5
8565509
Am J Hematol. 2006 Feb;81(2):147-8
16432857
Br J Haematol. 2001 Nov;115(2):253-6
11703318
Orv Hetil. 1996 Jun 16;137(24):1315-7
8927329
Ann Pathol. 1998 Jul;18(3):237-8
9706354
Acta Haematol. 1980;63(6):330-2
6774568
Radiographics. 2007 Oct;27 Suppl 1:S101-24
18180221
Leuk Lymphoma. 2003 Jul;44(7):1173-8
12916870
Am J Surg Pathol. 1994 Mar;18(3):288-95
8116797
Ann Hematol. 2003 Jul;82(7):397-404
12764549
Cancer. 1991 Sep 1;68(5):1031-4
1655211
Cancer. 1992 Nov 15;70(10):2451-9
1423175
Pediatr Radiol. 1995;25(1):56-7
7761167
Semin Oncol. 1999 Jun;26(3):357-64
10375092
Pathol Res Pract. 1996 Jan;192(1):37-43
8685040
Blood. 2004 Nov 15;104(10):3009-20
15265787
J Natl Med Assoc. 1994 May;86(5):365-8
8046764
Cancer. 1972 Jan;29(1):252-60
5007387
Cancer. 1990 Dec 15;66(12):2602-11
2249200