[Synthesis and properties of the myelopeptides with differentiating activity].
The bone marrow myelopeptides Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro (MP-4) and Val-Asp-Pro-Pro (MP-6) have been synthesised by a classical method and by a solid phase synthesis. The differentiating activity of MP-4 and MP-6 in human leukemia cells HL-60 and K-562 has been studied. Both peptides induce terminal differentiation of these cell lines but the mechanism of action of peptides MP-4 and MP-6 is distinguished.
Fonina
L A
LA
Kudriavtseva
E V
EV
Bespalova
Zh D
ZhD
Efremov
M A
MA
Mikhaĭlova
A A
AA
Kirilina
E A
EA
D002454:Cell Differentiation / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D009842:Oligopeptides; C502954:phenylalanyl-arginyl-prolyl-arginyl-isoleucyl-methionyl-threonyl-proline; C502956:valyl-aspartyl-prolyl-proline