Cerebral microbleeds and dilative remodeling of the basilar artery: a magnetic resonance imaging study.
This study was conducted to examine the relationship between cerebral microbleeds (CMBs), one of the manifestations of small-vessel diseases (SVDs), and basilar artery (BA) dilatation on magnetic resonance imaging (MRI). Clinical information and MRI images were reviewed for 149 outpatients aged 46-90 years, excluding those who had a previous symptomatic cerebrovascular event. CMBs were evaluated on T2∗-weighted MRI, and BA diameters were measured as the maximal width of the flow void on axial T2-weighted MRI to assess dilatation. Patients were divided into 2 groups, with CMBs and without CMBs, and clinical information and BA diameters were compared between the groups. Regression analyses of the data also were performed. The 2 groups had significant differences in mean blood pressure (MBP), low-density lipoprotein (LDL) and uricemic acid levels, and BA diameter. Adjusted logistic regression analysis showed that MBP (odds ratio [OR], 1.059 per 1 mm Hg; 95% confidence interval [CI], 1.019-1.101; P = .0035), LDL (OR, 0.976 per 1 mg/dL; 95% CI, 0.960-0.994; P = .0072), and BA diameter (OR, 3.266 per 1 mm; 95% CI, 1.504-7.103; P = .0028) each had an independent association with the presence of CMB. Adjusted multiple regression analysis showed that only BA diameter (β coefficient, 0.240; 95% CI, 0.775-3.734; P = .0031) was independently associated with the number of CMBs. Our data indicate that CMB, a manifestation of SVD, shows a strong association with BA dilatation.
Ichikawa
Hiroo
H
Department of Neurology, Showa University School of Medicine, Tokyo, Japan. h_ichikawa0527@yahoo.co.jp
Mukai
Masanori
M
Katoh
Hirotaka
H
Hieda
Sotaro
S
Murakami
Hidetomo
H
Kawamura
Mitsuru
M
D000368:Aged; D000369:Aged, 80 and over; D001488:Basilar Artery / Q000473:pathology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D059345:Cerebral Small Vessel Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007564:Japan; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D018810:Magnetic Resonance Angiography; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood; D014664:Vasodilation
D015415:Biomarkers; D008077:Lipoproteins, LDL; D014527:Uric Acid