title: Cadherins in cerebellar development: translation of embryonic patterning into mature functional compartmentalization.
abstract: Cadherins are cell adhesion molecules with multiple morphogenic functions in brain development, for example, in neuroblast migration and aggregation, axon navigation, neural circuit formation, and synaptogenesis. More than 100 members of the cadherin superfamily are expressed in the developing and mature brain. Most of the cadherins investigated, in particular classic cadherins and δ-protocadherins, are expressed in the cerebellum. For several cadherin subtypes, expression begins at early embryonic stages and persists until mature stages of cerebellar development. At intermediate stages, distinct Purkinje cell clusters exhibit unique rostrocaudal and mediolateral expression profiles for each cadherin. In the chicken, mouse, and other species, the Purkinje cell clusters are separated by intervening raphes of migrating granule cells. This pattern of Purkinje cell clusters/raphes is, at least in part, continuous with the parasagittal striping pattern that is apparent in the mature cerebellar cortex, for example, for zebrin II/aldolase C. Moreover, subregions of the deep cerebellar nuclei, vestibular nuclei and the olivary complex also express cadherins differentially. Neuroanatomical evidence suggests that the nuclear subregions and cortical domains that express the same cadherin subtype are connected to each other, to form neural subcircuits of the cerebellar system. Cadherins thus provide a molecular code that specifies not only embryonic structures but also functional cerebellar compartmentalization. By following the implementation of this code, it can be revealed how mature functional architecture emerges from embryonic patterning during cerebellar development. Dysfunction of some cadherins is associated with psychiatric diseases and developmental impairments and may also affect cerebellar function.
authors.affiliation: Institute of Anatomy I, University of Jena School of Medicine, Jena University Hospital, Teichgraben 7, 07743, Jena, Germany. redies@mti.uni-jena.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Redies
authors.forename: Franziska
authors.initials: F
authors.lastname: Neudert
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D019521:Body Patterning / Q000502:physiology*; D001927:Brain Diseases / Q000378:metabolism; D015820:Cadherins / Q000145:classification / Q000378:metabolism*; D002531:Cerebellum / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D004622:Embryo, Mammalian; D051379:Mice; D009434:Neural Pathways / Q000502:physiology; D055495:Neurogenesis; D011689:Purkinje Cells / Q000378:metabolism*
chemical_list: D015820:Cadherins
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