BRCA1 and BRCA2 families and the risk of skin cancer.
BRCA1 and BRCA2 mutation carriers have elevated risks of breast and ovarian cancers. The risks for cancers at other sites remain unclear. Melanoma has been associated with BRCA2 mutations in some studies, however, few surveys have included non-melanoma skin cancer. We followed 2729 women with a BRCA1 or BRCA2 mutation for an average of 5.0 years. These women were asked to report new cases of cancer diagnosed in themselves or in their family. The risks of skin cancer were compared for probands with BRCA1 and BRCA2 mutations. Of 1779 women with a BRCA1 mutation, 29 developed skin cancer in the follow-up period (1.6%). Of the 950 women with a BRCA2 mutation, 28 developed skin cancer (3.0%) (OR = 1.83 for BRCA2 versus BRCA1; 95% CI 1.08-3.10; P = 0.02). The odds ratio for basal cell carcinoma was higher (OR = 3.8; 95% CI 1.5-9.4; P = 0.002). BRCA2 mutation carriers are at increased risk for skin cancer, compared with BRCA1 carriers, in particular for basal cell carcinoma.
Ginsburg
Ophira M
OM
Department of Medicine, Division of Medical Oncology, University of Toronto, Toronto, ON, Canada.
Kim-Sing
Charmaine
C
Foulkes
William D
WD
Ghadirian
Parviz
P
Lynch
Henry T
HT
Sun
Ping
P
Narod
Steven A
SA
D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology
D019313:BRCA1 Protein; D024682:BRCA2 Protein
Am J Hum Genet. 2003 Jan;72(1):1-12
12474142
Br J Cancer. 2000 Aug;83(4):463-6
10945492
Am J Hum Genet. 1997 Jul;61(1):120-8
9245992
Anticancer Res. 2000 Jan-Feb;20(1B):559-61
10769725
N Engl J Med. 1997 May 15;336(20):1401-8
9145676
J Natl Cancer Inst. 1994 Nov 2;86(21):1600-8
7932824
J Natl Cancer Inst. 2003 Jan 1;95(1):75-6; author reply 77-8
12509407
J Am Acad Dermatol. 1994 May;30(5 Pt 1):774-8
8176018
Int J Cancer. 2002 Nov 10;102(2):188-91
12385017
Breast Cancer Res. 2003;5(6):R175-86
14580253
Science. 2004 Dec 24;306(5705):2187-91; author reply 2187-91
15622557
Lancet. 1998 Oct 24;352(9137):1337-9
9802270
Am J Hum Genet. 1995 Jan;56(1):265-71
7825587
J Natl Cancer Inst. 2003 Jan 1;95(1):76-7; author reply 77-8
12509408
Lancet. 1994 Mar 19;343(8899):692-5
7907678
J Natl Cancer Inst. 2004 Jan 7;96(1):15-21
14709734
Science. 2004 Dec 24;306(5705):2187-91; author reply 2187-91
15622558
Cancer Res. 2000 Jan 15;60(2):409-16
10667595
Ann Oncol. 2004 Dec;15(12):1834-41
15550590
Fam Cancer. 2009;8(1):29-32
18679827
Cancer Res. 1996 Aug 1;56(15):3409-14
8758903
Br J Cancer. 2007 Jan 15;96(1):11-5
17213823
J Natl Cancer Inst. 2003 Jan 1;95(1):73-4; author reply 77-8
12509405
J Natl Cancer Inst. 2003 Jan 1;95(1):78-9
12509410
Fam Cancer. 2007;6(4):453-61
17624602
Cancer Biol Ther. 2005 Dec;4(12):1409-14
16357511
Br J Cancer. 2001 Feb;84(4):475-7
11207040
Clin Cancer Res. 2000 Nov;6(11):4259-64
11106241
Clin Cancer Res. 2004 May 1;10(9):2918-21
15131025
J Natl Cancer Inst. 2004 Jan 7;96(1):68-70
14709740
J Natl Cancer Inst. 2003 Feb 5;95(3):214-21
12569143
J Natl Cancer Inst. 2003 Jan 1;95(1):74-5; author reply 77-8
12509406
J Natl Cancer Inst. 2006 Dec 6;98(23):1675-7
17148764
J Natl Cancer Inst. 1999 Aug 4;91(15):1310-6
10433620
Eur J Cancer. 1999 Aug;35(8):1248-57
10615237
Breast Cancer Res Treat. 2003 Sep;81(1):71-9
14531499
Cancer Res. 2002 Jul 1;62(13):3789-93
12097290
Int J Cancer. 2002 Mar 1;98(1):42-4
11857383
Am J Hum Genet. 1999 Sep;65(3):921-4
10441598
Am J Hum Genet. 2001 Mar;68(3):700-10
11179017
J Natl Cancer Inst. 2002 Aug 21;94(16):1221-6
12189225
Am J Hum Genet. 2000 Apr;66(4):1259-72
10739756
J Natl Cancer Inst. 2002 Sep 18;94(18):1358-65
12237281
J Natl Cancer Inst. 2002 Sep 18;94(18):1365-72
12237282
J Mol Med (Berl). 1997 Oct;75(10):758-61
9383000