[A case of del(16)(q22) in a patient with acute myeloid leukemia with complex karyotype].
Inversion of chromosome 16 [inv(16)(p13.1q22)] and t(16;16)(p13.1;q22) are associated with acute myelomonocytic leukemia (AMML) with eosinophilia and a favorable prognosis. On the other hand, patients with del(16)(q22) usually present with MDS or chronic myelomonocytic leukemia (CMML), which can evolve to AMML without eosinophilia, and this chromosomal aberration is associated with older age, a complex karyotype, and a poor prognosis. We report a case of AML with del(16)(q22) which showed a complex karyotype, absence of eosinophilia in bone marrow study and a poor response to chemotherapy.
Kim
Minki
M
Department of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, Korea.
Lee
Ji Won
JW
Lee
Jin Kyung
JK
Hong
Young Jun
YJ
Hong
Seok Il
SI
Kang
Hye Jin
HJ
Cho
Eun Hae
EH
Chang
Yoon Hwan
YH
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002872:Chromosome Deletion; D002885:Chromosomes, Human, Pair 16; D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D055017:Monocyte-Macrophage Precursor Cells / Q000166:cytology; D011379:Prognosis
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D003630:Daunorubicin