Novel 'nano in nano' composites for sustained drug delivery: biodegradable nanoparticles encapsulated into nanofiber non-wovens.
Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.
Beck-Broichsitter
Moritz
M
Department of Pharmaceutics and Biopharmacy, Philipps-Universität Marburg, 35037 Marburg, Germany.
Thieme
Marcel
M
Nguyen
Juliane
J
Schmehl
Thomas
T
Gessler
Tobias
T
Seeger
Werner
W
Agarwal
Seema
S
Greiner
Andreas
A
Kissel
Thomas
T
D004396:Coloring Agents / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004553:Electric Conductivity; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011098:Polyglactin 910 / Q000737:chemistry*; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013500:Surface Tension; D013844:Thiazoles / Q000737:chemistry*
D004396:Coloring Agents; D003374:Coumarins; D013844:Thiazoles; C517282:coumarin 6; D011098:Polyglactin 910