title: Acute postoperative endophthalmitis in a patient with Darier's disease.
abstract: A 58-year-old man with Darier's disease developed endophthalmitis 3 days following left-sided cataract extraction with intraocular lens implantation. Vitreous cultures were positive for Pseudomonas aeruginosa, similar to previously cultured hyperkeratotic plaques on the patient. Despite emergent vitrectomy and aggressive treatment with systemic, intravitreal, and topical fortified antibiotics, the patient required evisceration 19 days postoperatively. Bacterial overgrowth within hyperkeratotic plaques may increase the risk of endophthalmitis following intraocular surgery in patients with Darier's disease.
authors.affiliation: Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Aimee V
authors.initials: AV
authors.lastname: Chappelow
authors.forename: Gregory
authors.initials: G
authors.lastname: Kosmorsky
authors.forename: Craig
authors.initials: C
authors.lastname: Lewis
authors.forename: Julian D
authors.initials: JD
authors.lastname: Perry
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002386:Cataract / Q000150:complications*; D002387:Cataract Extraction / Q000009:adverse effects*; D007644:Darier Disease / Q000150:complications*; D009877:Endophthalmitis / Q000209:etiology* / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D017234:Eye Evisceration; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa
chemical_list: D000900:Anti-Bacterial Agents