title: Analysis of Gγ-158(C→T) polymorphism in hemoglobin E/β-thalassemia major in Southern China.
abstract: BACKGROUND
  The Gγ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about Gγ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This study aimed to explore the association between HbE/β-thalassemia major and this polymorphism in Southern China.
  
  
  RESULTS
  The frequency of the Gγ-158(C→T) polymorphism has been evaluated in 32 patients with HbE/β-thalassemia major from Southern China. Further analysis of the Gγ-158(C→T) polymorphism revealed the prominent frequency of this polymorphic pattern among HbE/β-thalassemia major patients (65.63%). The presence of this polymorphism was strongly correlated with the increase of HbF synthesis.
  
  
  CONCLUSIONS
  The frequency of the Gγ-158(C→T) polymorphism was relatively high in Southern Chinese patients with HbE/β-thalassemia major, often accompanying with high production of HbF. This feature appears to be different with reports in other races and regions.
authors.forename: Rong Rong
authors.initials: RR
authors.lastname: Liu
authors.forename: Ming Yue
authors.initials: MY
authors.lastname: Wang
authors.forename: Yong Rong
authors.initials: YR
authors.lastname: Lai
mesh_terms: D005319:Fetal Hemoglobin / Q000032:analysis; D006446:Hemoglobin E / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D017086:beta-Thalassemia / Q000235:genetics*
chemical_list: D006446:Hemoglobin E; D005319:Fetal Hemoglobin
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