title: The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats.
abstract: This study was designed to investigate the effects of strontium-substituted hydroxyapatite coatings with 10 mol% Ca(2+) replaced by Sr(2+) (10% SrHA) on implant fixation in ovariectomized (OVX) rats. Coatings of HA and 10% SrHA were prepared on the surface of titanium implant using sol-gel dip methods, and then characterized by Scanning Electron Microscope, Atomic Force Microscope, X-ray diffraction, X-ray Photoemission Spectroscopy, and an automatic scratch tester. Twelve weeks after bilateral ovariectomy, twenty OVX rats accepted implant insertion in the proximal tibiae, half with HA-coated implants and the other half with 10% SrHA coated implants. After 12-week healing period, 10% SrHA coated implants revealed improved osseointegration compared to HA, with the bone area ratio and bone-to-implant contact increased by 70.9% and 49.9% in histomorphometry, the bone volume ratio and percent osseointegration by 73.7% and 45.2% in micro-CT evaluation, and the maximal push-out force and ultimate shear strength by 107.2% and 132.9% in push out test. These results demonstrated that 10% SrHA coatings could enhance implant osseointegration in OVX rats, and suggested the feasibility of using SrHA coatings to improve implant fixation in osteoporotic bone.
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, Sichuan University West China College of Stomatology, 14 Section 3 Ren Min Nan Lu, Chendgu 610041, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Songsong
authors.initials: S
authors.lastname: Zhu
authors.forename: En
authors.initials: E
authors.lastname: Luo
authors.forename: Jihua
authors.initials: J
authors.lastname: Li
authors.forename: Ge
authors.initials: G
authors.lastname: Feng
authors.forename: Yunmao
authors.initials: Y
authors.lastname: Liao
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000268:Adhesiveness / Q000187:drug effects; D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D005260:Female; D006882:Hydroxyapatites / Q000494:pharmacology*; D020007:Implants, Experimental; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D010052:Ovariectomy; D056951:Photoelectron Spectroscopy; D019919:Prosthesis Implantation / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013324:Strontium / Q000494:pharmacology*; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D014961:X-Ray Diffraction; D055114:X-Ray Microtomography
chemical_list: D020099:Coated Materials, Biocompatible; D006882:Hydroxyapatites; C076185:strontium hydroxyapatite; D013324:Strontium