title: Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction.
abstract: A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Chang
authors.initials: C
authors.lastname: Sun
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003486:Cyanides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013871:Thiones / Q000737:chemistry*
chemical_list: D003486:Cyanides; D007097:Imines; D011759:Pyrrolidines; D013871:Thiones; C032519:pyrrolidine