Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol.
Two efficient routes are reported for the synthesis of both enantiomers of trifluoroalaninol in enantiopure form. The first pathway involves a Strecker-type reaction performed from a chiral trifluoromethyloxazolidine (Fox). The second route, which is more direct, involves, as a key step, the reduction of chiral oxazolidines or imines derived from ethyl trifluoropyruvate.
Pytkowicz
Julien
J
Université de Cergy-Pontoise, Laboratoire SOSCO, F-95000, Cergy-Pontoise, France.
Stéphany
Olivier
O
Marinkovic
Sinisa
S
Inagaki
Sébastien
S
Brigaud
Thierry
T
D010080:Oxazoles / Q000737:chemistry*; D011412:Propanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D019289:Pyruvic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
D010080:Oxazoles; D011412:Propanolamines; C513102:ethyl trifluoropyruvate; C064210:oxazolidine; C034448:2-aminopropanol; D019289:Pyruvic Acid