title: Mass spectrometry in high-throughput proteomics: ready for the big time.
abstract: Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected challenges ahead and promising strategies for success.
authors.affiliation: Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. tommy.nilsson@mcgill.ca
authors.forename: Tommy
authors.initials: T
authors.lastname: Nilsson
authors.forename: Matthias
authors.initials: M
authors.lastname: Mann
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
authors.forename: John R
authors.initials: JR
authors.lastname: Yates
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: John J M
authors.initials: JJ
authors.lastname: Bergeron
mesh_terms: D030562:Databases, Protein; D006801:Humans; D013058:Mass Spectrometry / Q000639:trends*; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D020543:Proteome
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