Opening of DNA double helix at room temperature: Application of alpha-cyclodextrin self-aggregates.
Self-aggregation of alpha-cyclodextrin (alpha-CD) can induce DNA opening at room temperature (25 degrees C) owing to the hydroxyl groups on the surface of the spherical aggregates of alpha-CD, which promote hydrogen bonding with the flipped-out bases in DNA duplex prohibiting them from reverting back.
Jaffer
Syed S
SS
Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, 741252, WB, India.
Ghosh
Prasun
P
Das
Anindita
A
Purkayastha
Pradipta
P
D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D013696:Temperature; D047391:alpha-Cyclodextrins / Q000737:chemistry*
D047391:alpha-Cyclodextrins; D004247:DNA; C032613:alpha-cyclodextrin