Sniffing out the contributions of the olfactory tubercle to the sense of smell: hedonics, sensory integration, and more?
Since its designation in 1896 as a putative olfactory structure, the olfactory tubercle has received little attention in terms of elucidating its role in the processing and perception of odors. Instead, research on the olfactory tubercle has mostly focused on its relationship with the reward system. Here we provide a comprehensive review of research on the olfactory tubercle-with an emphasis on the likely role of this region in olfactory processing and its contributions to perception. Further, we propose several testable hypotheses regarding the likely involvement of the olfactory tubercle in both basic (odor detection, discrimination, parallel processing of olfactory information) and higher-order (social odor processing, hedonics, multi-modal integration) functions. Together, the information within this review highlights an understudied yet potentially critical component in central odor processing.
Wesson
Daniel W
DW
Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA. dwesson@nki.rfmh.org
Wilson
Donald A
DA
D000818:Animals; D006801:Humans; D009812:Odorants; D009833:Olfactory Pathways / Q000502:physiology*; D010465:Perception / Q000502:physiology*; D012677:Sensation / Q000502:physiology*; D012903:Smell / Q000502:physiology*
Brain Res Brain Res Rev. 2005 Dec 15;50(2):305-35
16229895
J Comp Physiol Psychol. 1978 Oct;92(5):917-27
282297
J Neurophysiol. 2009 Mar;101(3):1613-9
18922946
J Comp Neurol. 2004 Aug 23;476(3):290-300
15269971
Eur J Neurosci. 2010 Feb;31(4):659-72
20141530
J Comp Neurol. 1991 Apr 15;306(3):447-61
1713925
Brain Res. 1975 Apr 25;88(1):64-8
1122403
J Comp Neurol. 1981 Mar 20;197(1):81-98
6164702
Psychopharmacology (Berl). 2009 Aug;205(2):293-303
19404615
J Comp Neurol. 1990 Apr 22;294(4):607-22
2341628
Neuroscience. 1988 Oct;27(1):1-39
3059226
Brain Cogn. 2004 Jun;55(1):11-29
15134840
J Comp Neurol. 1993 Jan 8;327(2):205-19
8425942
Brain Res Bull. 1982 Jun;8(6):711-9
6182961
J Comp Neurol. 1989 Jun 15;284(3):405-28
2474005
Cereb Cortex. 2008 Jun;18(6):1239-52
17878174
Otolaryngol Head Neck Surg. 1988 Feb;98(2):116-20
3128753
Trends Neurosci. 2004 Aug;27(8):468-74
15271494
Neuron. 2005 Apr 21;46(2):285-96
15848806
J Neurosci. 2006 Jan 25;26(4):1247-59
16436612
Neurosci Biobehav Rev. 2006;30(5):613-50
16457886
Rev Neurosci. 2001;12(2):111-20
11392453
Brain Res. 1977 Nov 11;136(2):355-9
922489
Neuroreport. 2001 Mar 5;12(3):565-8
11234764
PLoS Biol. 2008 Oct 28;6(10):e258
18959481
J Comp Neurol. 1984 Feb 20;223(2):203-22
6200519
Int J Dev Neurosci. 1986;4(3):251-71
3455589
J Comp Neurol. 1984 Oct 1;228(4):571-97
6490970
Eur J Neurosci. 2001 May;13(9):1767-80
11359528
Brain Struct Funct. 2007 Sep;212(2):121-32
17717687
J Neurophysiol. 2007 Mar;97(3):1969-76
17215504
Nat Neurosci. 2001 Apr;4(4):355-6
11276223
Neuroscience. 2001;102(1):11-21
11226666
J Neurosci. 2003 Oct 15;23(28):9305-11
14561857
Neuroscience. 1987 Oct;23(1):103-20
3683859
J Comp Neurol. 1980 Dec 1;194(3):519-34
7451680
Semin Cell Biol. 1994 Feb;5(1):65-74
8186397
Synapse. 2002 Oct;46(1):4-10
12211093
Chem Senses. 2001 Jun;26(5):551-76
11418502
J Comp Neurol. 1988 Sep 22;275(4):553-79
3192757
J Neurosci. 1984 Jun;4(6):1626-38
6374062
J Comp Neurol. 1982 Mar 1;205(3):207-18
7076893
Neuroscience. 2007 Mar 30;145(3):1059-76
17270353
J Comp Neurol. 1987 Nov 1;265(1):1-24
3693600
Annu Rev Neurosci. 2006;29:163-201
16776583
Brain Res. 1997 Jan 9;744(2):253-71
9027385
Brain Res Bull. 2008 Mar 18;75(2-4):467-73
18331916
J Comp Neurol. 2007 Jul 1;503(1):1-34
17480025
Physiol Rev. 2006 Apr;86(2):409-33
16601265
J Neurosci. 2008 Jun 25;28(26):6664-9
18579740
Exp Brain Res. 1986;62(3):515-27
2424778
Ann N Y Acad Sci. 2009 Jul;1170:647-57
19686207
J Comp Neurol. 1978 Sep 15;181(2):375-95
80412
J Neurophysiol. 2001 Dec;86(6):2986-97
11731555
Neuroimaging Clin N Am. 2001 May;11(2):237-50, viii
11489737
BMC Neurosci. 2005 May 31;6:38
15927048
PLoS One. 2010 Jan 15;5(1):e8741
20090902
Neuroscience. 1993 Oct;56(4):841-64
8284038
J Neurophysiol. 1998 Mar;79(3):1425-40
9497422
Curr Opin Psychiatry. 2010 Mar;23(2):97-102
20051859
J Neurophysiol. 1993 Apr;69(4):1331-7
8492167
Behav Brain Res. 1997 Mar;84(1-2):117-27
9079778
J Neurophysiol. 1995 Aug;74(2):733-50
7472378
Neuropeptides. 1999 Jun;33(3):206-11
10657493
Neuroscience. 1990;34(3):707-31
2352648
J Comp Neurol. 2005 Jul 25;488(2):224-31
15924345
J Neurosci. 2009 Aug 19;29(33):10287-98
19692603
J Neurosci. 2008 Sep 10;28(37):9227-38
18784303
Nat Neurosci. 2008 Dec;11(12):1378-80
18978781
Physiol Behav. 1986;36(2):319-24
3961008
Neuroscience. 1982;7(11):2609-35
7155344
J Chem Neuroanat. 2002 Feb;23(2):75-104
11841914
Neuron. 2005 Dec 22;48(6):1039-53
16364906
J Neurophysiol. 2007 Nov;98(5):2716-28
17855583
Experientia. 1968 Sep 15;24(9):958-9
5709053
J Neurochem. 1979 Jul;33(1):299-302
458455
Cells Tissues Organs. 2009;190(5):256-85
19287129
Neuron. 2001 Nov 20;32(4):723-35
11719211
J Comp Neurol. 1999 Jun 14;408(4):532-48
10340503
Electroencephalogr Clin Neurophysiol. 1979 Jun;46(6):665-74
87311
Brain Res Bull. 1980 Jul-Aug;5(4):383-9
7407635
J Neurophysiol. 1988 Jun;59(6):1770-82
3404204
J Neurosci. 1982 Oct;2(10):1439-45
7119866
J Comp Neurol. 1983 Apr 20;215(4):465-71
6134758
J Anat. 1970 Sep;107(Pt 2):215-37
5487119
Nat Neurosci. 2009 Jan;12(1):77-84
19043410
Brain Res Bull. 1983 Jun;10(6):775-93
6616269
J Comp Neurol. 1978 Apr 15;178(4):711-40
632378
Neuron. 2007 Jan 18;53(2):279-92
17224408
J Neurosci. 2010 Feb 24;30(8):3013-21
20181598
Trends Neurosci. 2009 Oct;32(10):525-31
19758713
Science. 2008 Mar 28;319(5871):1842-5
18369149
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15206-11
17005727
Neuroscience. 2004;126(4):1033-41
15207336
Chem Senses. 2004 Mar;29(3):225-33
15047597
Brain Res. 1981 Aug;254(1):141-56
7272766
Cold Spring Harb Symp Quant Biol. 1990;55:599-610
2132840
BMC Neurosci. 2007 Nov 29;8:103
18047654
Neuropsychopharmacology. 2008 Jul;33(8):1827-34
17957218
Brain Res Rev. 2007 Nov;56(1):27-78
17574681
Semin Cell Dev Biol. 2006 Aug;17(4):411-23
16765614
Arch Neurol. 1998 Jan;55(1):84-90
9443714
Neuroscience. 1992;46(4):755-84
1371855
Brain Res. 1975 Nov 21;98(3):596-600
1182541
J Neurophysiol. 2009 Feb;101(2):1073-88
19091924
Prog Neurobiol. 2009 Jan 12;87(1):21-30
18929620
Neuroscience. 2010 Aug 11;169(1):415-21
20472036
J Anat. 1977 Apr;123(Pt 2):515-25
558181
J Comp Physiol Psychol. 1973 Jan;82(1):30-6
4567890
J Anat. 1968 Nov;103(Pt 3):413-32
4879162
Physiol Behav. 1972 Oct;9(4):573-9
4670856
J Neurosci. 2000 Sep 15;20(18):6974-82
10995842
Eur J Neurosci. 2007 Jul;26(2):463-75
17623023
Brain Res. 1977 Jun 24;129(1):152-7
68803
J Neurophysiol. 2000 Jan;83(1):537-51
10634894
J Comp Neurol. 2008 May 10;508(2):212-37
18311787
J Neurophysiol. 2008 Jul;100(1):2-7
18463176
Trends Neurosci. 2004 Mar;27(3):120-3; discussion 123-4
15046082
Nat Neurosci. 2007 May;10(5):631-9
17450136
Nat Neurosci. 2005 Jan;8(1):114-20
15608635
Am J Psychiatry. 2003 Oct;160(10):1726-39
14514480
J Neurophysiol. 1992 May;67(5):1222-9
1597708
Neuron. 2003 Jul 17;39(2):375-86
12873392
J Neurophysiol. 1989 Jun;61(6):1161-77
2746317
J Comp Neurol. 1988 Sep 22;275(4):580-603
3192758
J Comp Neurol. 1984 Feb 20;223(2):177-202
6200518
J Comp Neurol. 2004 Apr 5;471(3):314-32
14991564
Brain Behav Evol. 2008;71(3):216-30
18322362
Neuroscience. 2006 Dec 28;143(4):1065-83
17027173
Eur J Neurosci. 2002 Nov;16(10):1917-24
12453055
J Comp Neurol. 1983 May 20;216(3):264-91
6306065
J Comp Neurol. 1990 Mar 1;293(1):103-24
2312788
J Comp Neurol. 1994 Aug 15;346(3):403-34
7527806
J Comp Neurol. 2003 Mar 17;457(4):361-73
12561076
J Comp Neurol. 1993 Jan 8;327(2):220-32
8425943
J Comp Neurol. 1983 Mar 20;215(1):63-77
6853766
Int J Dev Neurosci. 1985;3(2):135-47
24874595
Brain Res. 2008 Jul 18;1220:2-32
17964556
Neuroscience. 1993 Nov;57(1):113-42
8278047
Trends Neurosci. 1998 Aug;21(8):323-31
9720596
Horm Behav. 2004 Sep;46(3):247-56
15325226
Nat Neurosci. 2009 Jul;12(7):932-8
19483688
Brain Behav Evol. 1977;14(4):241-50
871899
Ergeb Anat Entwicklungsgesch. 1970;43(6):3-62
4995376
CRC Crit Rev Clin Neurobiol. 1987;2(4):335-55
3297494