Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form.
Herein we report that Aβ aggregates, not Aβ monomer, can convert Z-DNA back to B-form, and curcumin, a well-known Aβ aggregation inhibitor, can stop DNA Z-B transition studied by means of biophysical and biochemical methods.
Geng
Jie
J
Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022.
Zhao
Chuanqi
C
Ren
Jinsong
J
Qu
Xiaogang
X
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology; D043542:DNA, Z-Form / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D055503:Protein Multimerization
D016229:Amyloid beta-Peptides; D043542:DNA, Z-Form; D004791:Enzyme Inhibitors; D003474:Curcumin