Orthopedic complications related to growth hormone therapy in a pediatric population.
Since the introduction of recombinant growth hormone, its use has diversified and multiplied. Growth hormone is now the recommended therapy for a growing indication to all forms of short stature because of its direct and indirect role on bone growth. Hereby, we discuss the orthopedic complications associated with growth hormone treatment in pediatric patients. These complications include carpal tunnel syndrome, Legg-Calve-Perthes' disease, scoliosis, and slipped capital femoral epiphysis. Their incidence rates recorded in several growth hormone therapy-related pharmacovigilance studies will be summarized in this study with focused discussion on their occurrence in the pediatric and adolescent age groups. The pathogenesis of these complications is also reviewed.
Haidar
Rachid K
RK
Department of Surgery, American University of Beirut, Lebanon. rh00@aub.edu.lb
Nasrallah
Mona P
MP
Der-Boghossian
Asdghig H
AH
Ghanem
Ismat B
IB
D000293:Adolescent; D002349:Carpal Tunnel Syndrome / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004839:Epiphyses, Slipped / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects*; D006801:Humans; D007861:Lebanon / Q000453:epidemiology; D007873:Legg-Calve-Perthes Disease / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D012600:Scoliosis / Q000139:chemically induced* / Q000453:epidemiology
D019382:Human Growth Hormone