Colorectal cancer in young patients in Israel: a distinct clinicopathological entity?
OBJECTIVE
This study was designed to characterize the entity of colorectal cancer (CRC) in young patients and to evaluate whether it has any unique epidemiological or clinicopathological features.


METHODS
The study population consisted of all consecutive young (≤50 years old at diagnosis) patients with CRC who were diagnosed during the years 1997-2007 and were treated at our institution, and a matching group of patients (>50 years at diagnosis). The medical files of these patients were reviewed, and the epidemiological, clinical, and pathological features of both groups were compared.


RESULTS
There were 406 patients: 203 in each group. The features of the older group were typical for patients with CRC, but the younger group showed female predominance, different ethnic composition, prevalence of family history of cancer and hereditary CRC syndromes, and lower incidence of polyps. The incidence of left-sided tumors and advanced stages (III-IV) at diagnosis was higher in the younger patients. Mucinous/signet ring histology, grade, stage, lymphatic and vascular invasion were all predictive of survival, whereas age was not.


CONCLUSIONS
Colorectal cancer in young patients was found to display a cluster of unique characteristics but fewer than previously reported and young age by itself was not found to impact patient outcome.
Shemesh-Bar
L
L
Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Tel-Aviv, Israel.
Kundel
Y
Y
Idelevich
E
E
Sulkes
J
J
Sulkes
A
A
Brenner
B
B
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
Fam Cancer. 2004;3(3-4):177-92
15516840
Tohoku J Exp Med. 2003 Feb;199(2):85-93
12705353
Am J Gastroenterol. 1997 Sep;92(9):1505-9
9317073
Dis Colon Rectum. 2004 Dec;47(12):2064-9
15657655
Am Surg. 2003 Oct;69(10):866-72
14570365
Br J Surg. 2003 Feb;90(2):205-14
12555297
Tumori. 2001 Mar-Apr;87(2):74-7
11401210
World J Surg. 2004 Jun;28(6):558-62
15366745
Colorectal Dis. 2004 May;6(3):191-4
15109385
Tech Coloproctol. 2004 Nov;8 Suppl 1:s147-8
15655603
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
17237035
Am J Surg. 2004 Mar;187(3):343-8
15006562
Cancer Chemother Rep. 1966 Mar;50(3):163-70
5910392
Lancet. 1993 Mar 20;341(8847):736-40
8095636
Fam Cancer. 2004;3(3-4):207-14
15516843
ANZ J Surg. 2001 Dec;71(12):707-10
11906383