Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
Eight new germacrane-type sesquiterpenoids, volvalerenals A-E (2-6) and volvalerenic acids A-C (7-9), along with four known compounds, were isolated from a chloroform extract of the roots of Valeriana officinalis var. latifolia. The structures and relative configurations of 2-9 were elucidated on the basis of spectroscopic data interpretation. The effects of all compounds isolated on acetylcholinesterase were evaluated.
Wang
Peng-Cheng
PC
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Ran
Xin-Hui
XH
Chen
Rui
R
Luo
Huai-Rong
HR
Liu
Yu-Qing
YQ
Zhou
Jun
J
Zhao
You-Xing
YX
D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013619:Tacrine / Q000494:pharmacology; D014632:Valerian / Q000737:chemistry*
D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D045788:Sesquiterpenes, Germacrane; D013619:Tacrine