High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries.
Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. A total of 1,294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age 70-74, and leveled off at older age; female incidence increased from 0.50/100,000 at age 30-34 to 16.5/100,000 at age 80-84. However, age-specific incidence of second HN cancers after a first HN cancer in men was around 200-300/100,000 between age 40-44 and age 70-74 and tended to decline at subsequent ages (150/100,000 at age 80-84); in women, incidence of second HN cancers was around 200-300/100,000 between age 45-49 and 80-84. The patterns of age-specific incidence were consistent for different subsites of second HN cancer and sexes; moreover, they were similar for age-specific incidence of first primary HN cancer in patients who subsequently developed a second HN cancer. The incidence of second HN cancers does not increase with age, but remains constant, or if anything, decreases with advancing age.
Bosetti
Cristina
C
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. cristina.bosetti@marionegri.it
Scelo
Ghislaine
G
Chuang
Shu-Chun
SC
Tonita
Jon M
JM
Tamaro
Sharon
S
Jonasson
Jon G
JG
Kliewer
Erich V
EV
Hemminki
Kari
K
Weiderpass
Elisabete
E
Pukkala
Eero
E
Tracey
Elizabeth
E
Olsen
Jorgen H
JH
Pompe-Kirn
Vera
V
Brewster
David H
DH
Martos
Carmen
C
Chia
Kee-Seng
KS
Brennan
Paul
P
Hashibe
Mia
M
Levi
Fabio
F
La Vecchia
Carlo
C
Boffetta
Paolo
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries
J Natl Cancer Inst. 2002 Apr 3;94(7):529; author reply 529-30
11929954
Head Neck. 1999 May;21(3):204-10
10208662
IARC Sci Publ. 1987;(82):1-406
3329634
Int J Cancer. 2005 Sep 20;116(5):820-3
15838829
Br J Cancer. 2005 Jul 11;93(1):159-66
15970927
Cancer. 1992 Jul 1;70(1):14-9
1606536
Int J Cancer. 1994 Feb 1;56(3):320-3
8314317
Am J Epidemiol. 2008 Feb 15;167(4):468-73
18056925
Cancer. 1953 Sep;6(5):963-8
13094644
Int J Cancer. 2007 Aug 1;121(3):694-7
17417783
IARC Sci Publ. 1991;(95):64-81
1894333
Epidemiology. 2009 Mar;20(2):175-80
19057388
Nat Genet. 2000 Dec;26(4):411-4
11101836
Br J Cancer. 1981 Jul;44(1):1-14
6789853
Br J Cancer. 1957 Jun;11(2):161-9
13460138
Br J Cancer. 1994 Apr;69(4):784-7
8142267
J Oral Pathol Med. 2003 Sep;32(8):443-9
12901724
Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):249-56
10750662
Int J Cancer. 2006 Dec 1;119(11):2702-4
16991126
Int J Cancer. 2008 Nov 15;123(10):2390-6
18729183
Br J Cancer. 1981 Jul;44(1):15-23
6789854
Oral Oncol. 2003 Apr;39(3):232-9
12618195
Cancer Causes Control. 1998 Aug;9(4):463-4; discussion 465
9794180
Nat Genet. 2000 Dec;26(4):390-1
11101827
J Natl Cancer Inst. 2001 Aug 15;93(16):1264-6
11504772
Cancer. 1995 Mar 15;75(6):1343-53
7882285
Eur J Cancer Prev. 2008 Oct;17(5):385-8
18714177
Epidemiology. 2003 Sep;14(5):552-8
14501270
Int J Cancer. 2000 Dec 15;88(6):998-1002
11093827
Cancer Res. 2003 Apr 15;63(8):1727-30
12702551