The role of FSH and TSH in bone loss and its clinical relevance.
Osteoporosis, a global health problem, is now frequently recognized to be secondary to alterations in the pituitary-bone axis. This review examines the current evidence for how dysregulation of the pituitary-bone axis leads to osteoporotic bone loss. Specifically, perimenopausal bone loss in the context of follicle-stimulating hormone action, and hyperthyroid bone loss in the context of thyroid-stimulating hormone action are explored. From the reviewed scientific findings, recommendations for early diagnosis and better clinical management of bone loss are made.
Agrawal
Manasi
M
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. drmanasiagrawal@gmail.com
Zhu
Guangyu
G
Sun
Li
L
Zaidi
Mone
M
Iqbal
Jameel
J
D000818:Animals; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010024:Osteoporosis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D047648:Perimenopause / Q000502:physiology; D013972:Thyrotropin / Q000502:physiology*
D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
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