title: A novel and non-destructive method to examine meniscus architecture using 9.4 Tesla MRI.
abstract: OBJECTIVE
  To investigate the ability of high-field (9.4 T) magnetic resonance (MR) imaging to delineate porcine knee meniscal tissue structure and meniscal tears.
  
  
  METHODS
  Porcine knees were obtained from a local abattoir, and eight medial menisci with no visible defects were dissected. Lesions simulating longitudinal tears were created on two of the menisci. MR images of the menisci were obtained at 9.4 T using a three-dimensional (3D)-FLASH sequence. A detailed 3D internal architecture of the intact and injured menisci was demonstrated on high-resolution MR images.
  
  
  RESULTS
  High-resolution 3D MR imaging allowed visualisation of internal architecture of the meniscus and disruption to the internal structural network in damage models. The architecture of the porcine knee meniscus revealed by the MR scans appeared similar to the structures visualised by histology in previously reported studies.
  
  
  CONCLUSIONS
  High-field MRI is a non-destructive technique to examine the internal structural components and damage/wear of meniscal tissue. It has tremendous potential in the field of functional cartilage/meniscus biomechanics and biotribology.
authors.affiliation: Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK. manyiwang@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Radjenovic
authors.forename: T W
authors.initials: TW
authors.lastname: Stapleton
authors.forename: R
authors.initials: R
authors.lastname: Venkatesh
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: E
authors.initials: E
authors.lastname: Ingham
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: Z
authors.initials: Z
authors.lastname: Jin
mesh_terms: D000818:Animals; D002102:Cadaver; D002356:Cartilage / Q000473:pathology; D007718:Knee Injuries / Q000473:pathology*; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008592:Menisci, Tibial / Q000473:pathology*; D013552:Swine; D000070600:Tibial Meniscus Injuries
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