Control of neurotransmitter release: From Ca2+ to voltage dependent G-protein coupled receptors.
This review discusses two theories that try to explain mechanisms of control of neurotransmitter release in fast synapses: the Ca(2+) hypothesis and the Ca(2+) voltage hypothesis. The review summarizes experimental results that are incompatible with predictions from the Ca(2+) hypothesis and concludes that Ca(2+) is involved in the control of the amount of release but not in the control of the time course of evoked release, i.e., initiation and termination of evoked release. Results summarizing direct effects of changes in membrane potential on the release machinery are then presented. These changes in membrane potential affect the affinity (for the transmitter) of presynaptic autoinhibitory G-protein coupled receptors (GPCRs). The voltage dependence of these GPCRs and their pivotal role in determining the time course of evoked release is discussed.
Parnas
Itzchak
I
Department of Neurobiology, Institute of life Science, The Hebrew University, Edmon Safra Campus, Jerusalem, Israel. parnas@huji.ac.il
Parnas
Hanna
H
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
D015220:Calcium Channels; D018377:Neurotransmitter Agents; D043562:Receptors, G-Protein-Coupled; D002118:Calcium
Curr Opin Neurobiol. 1999 Jun;9(3):305-13
10395573
J Neurophysiol. 2005 Sep;94(3):1912-9
15888526
J Physiol. 1980 Nov;308:79-97
6112267
Eur J Neurosci. 2009 Oct;30(7):1219-26
19769588
J Physiol. 1968 Mar;195(2):481-92
4296699
J Physiol. 1973 Jan;228(2):459-97
4346994
Physiol Rev. 1989 Jul;69(3):864-989
2568648
Neuron. 2004 Sep 30;44(1):5-21
15450156
Eur J Neurosci. 1996 Jan;8(1):116-26
8713455
Neuron. 2008 Sep 25;59(6):861-72
18817727
J Physiol. 1967 Sep;192(2):407-36
4383089
Biophys J. 1981 Mar;33(3):323-51
6261850
Science. 1996 Oct 25;274(5287):594-7
8849448
J Neurophysiol. 1972 Nov;35(6):903-14
4347420
J Biol Chem. 2003 Jun 20;278(25):22482-91
12684524
Neuron. 2003 Oct 9;40(2):331-46
14556712
J Biol Chem. 1993 May 5;268(13):9824-38
8387506
Biochem Biophys Res Commun. 2008 Dec 26;377(4):1216-21
18983826
Nat Neurosci. 2005 May;8(5):597-605
15834421
Biophys J. 1985 Sep;48(3):485-98
2412607
J Membr Biol. 1994 Dec;142(3):267-79
7707358
Epileptic Disord. 1999 Mar;1(1):7-19
10937127
J Neurophysiol. 1999 Jun;81(6):3044-53
10368419
Nature. 1994 Oct 6;371(6497):513-5
7935764
Biophys J. 1981 Mar;33(3):289-321
7225510
J Pharmacol Exp Ther. 1986 Nov;239(2):522-8
3772807
Ann N Y Acad Sci. 1991;635:365-81
1683754
J Neurosci. 2003 Aug 6;23(18):7059-68
12904466
J Physiol. 1999 Feb 1;514 ( Pt 3):769-82
9882749
Biophys J. 1996 Apr;70(4):2030-2
8785362
Neurosci Lett. 1991 Apr 29;125(2):215-8
1908959
J Neurosci. 2002 May 1;22(9):3426-33
11978819
Annu Rev Pharmacol Toxicol. 1997;37:205-37
9131252
J Biol Chem. 1999 Oct 8;274(41):29519-28
10506217
J Physiol. 1954 Jun 28;124(3):553-9
13175198
J Theor Biol. 1981 Jul 7;91(1):125-69
6117676
J Neurophysiol. 2003 Apr;89(4):1954-67
12686574
Synapse. 2008 Jun;62(6):476-80
18361445
Br J Pharmacol. 2004 May;142(1):113-24
15066904
Proc R Soc Lond B Biol Sci. 1973 Jul 3;183(1073):421-5
4147099
Proc R Soc Lond B Biol Sci. 1977 Feb 11;196(1122):59-72
15274
J Physiol. 1991 Jun;437:201-20
1653851
Biophys J. 1992 Mar;61(3):671-82
1354503
Cell Signal. 1997 Dec;9(8):551-73
9429760
Annu Rev Neurosci. 1999;22:443-85
10202545
Pharmacol Rev. 1998 Dec;50(4):723-60
9860808
Physiol Rev. 1999 Jul;79(3):1019-88
10390521
Science. 2000 Aug 11;289(5481):953-7
10937999
J Physiol. 1980 Jun;303:299-314
6253620
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15200-5
14630950
J Physiol. 1957 Oct 30;138(3):434-44
13481883
Br J Pharmacol. 2006 Jan;147 Suppl 1:S56-62
16402121
Biophys Chem. 1988 Feb;29(1-2):85-93
2896021
J Physiol. 1995 Feb 1;482 ( Pt 3):511-20
7738845
J Physiol. 2009 Feb 1;587(3):513-20
19074969
J Physiol. 1952 Apr;116(4):507-15
14946716
Nature. 2006 Jun 8;441(7094):761-5
16625207
J Physiol. 1997 Oct 15;504 ( Pt 2):251-8
9365901
Trends Pharmacol Sci. 2008 Aug;29(8):421-9
18621424
Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1486-91
8643659
Nat Neurosci. 2005 Apr;8(4):421-5
15778713
Bull Math Biol. 2000 Jul;62(4):717-57
10938630
Curr Opin Neurobiol. 2009 Jun;19(3):254-62
19581079
Annu Rev Biochem. 1987;56:615-49
3113327
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1692-7
9990086
J Physiol. 2000 Sep 1;527 Pt 2:203-12
10970423
Trends Neurosci. 1988 Oct;11(10):458-64
2469165
Physiol Rev. 2000 Apr;80(2):555-92
10747201
J Theor Biol. 1997 Oct 7;188(3):261-76
9344731
J Biol Chem. 1985 Mar 25;260(6):3440-50
3838314
Science. 2006 May 19;312(5776):1008-9
16709774
Neuron. 2008 Nov 6;60(3):469-76
18995821
J Physiol. 1985 Oct;367:143-62
2414438
J Neurosci. 1989 Oct;9(10):3558-67
2795140
Trends Pharmacol Sci. 1997 Mar;18(3):95-9
9133779
Eur J Neurosci. 2005 Jan;21(1):278-82
15654866
Curr Opin Neurobiol. 2005 Jun;15(3):266-74
15919191
Neuron. 2009 May 28;62(4):539-54
19477155
J Theor Biol. 1986 Apr 21;119(4):481-99
2875222
Annu Rev Pharmacol Toxicol. 1993;33:109-47
8388192
Eur J Neurosci. 2007 Oct;26(8):2160-8
17953614
J Physiol. 1987 Jul;388:487-94
2888884
J Neurosci. 2009 Sep 30;29(39):12196-209
19793978
Neuron. 2008 Nov 6;60(3):456-68
18995820
Nat Neurosci. 2005 Apr;8(4):426-34
15750590
Annu Rev Pharmacol Toxicol. 1998;38:201-27
9597154
J Physiol. 2003 Mar 15;547(Pt 3):665-89
12562955
J Physiol. 1967 Nov;193(2):419-32
6065887
Sci STKE. 2003 Nov 25;2003(210):pe52
14645810
Pflugers Arch. 1984 Nov;402(3):225-34
6151642
J Neurophysiol. 1999 Feb;81(2):634-42
10036266
Science. 2009 Jan 23;323(5913):474-7
19164740
Science. 2001 Apr 13;292(5515):293-7
11303105
Science. 2006 Mar 3;311(5765):1290-3
16513983
J Physiol. 1991 Jan;432:327-41
1653322
Nature. 1989 Jul 13;340(6229):153-6
2567963
J Physiol. 1968 Mar;195(2):471-80
4296698
Nat Methods. 2007 Aug;4(8):619-28
17664946
J Neurosci. 2005 Mar 23;25(12):3113-25
15788768
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:483-95
14278409
Nature. 2005 Jun 30;435(7046):1239-43
15902207
FEBS Lett. 1988 Dec 5;241(1-2):119-25
3197827
Annu Rev Neurosci. 2004;27:509-47
15217342
Neuron. 2007 May 24;54(4):567-81
17521570
Trends Neurosci. 2007 Feb;30(2):54-61
17169441
Trends Neurosci. 1997 May;20(5):204-12
9141196
Pflugers Arch. 1982 Dec;395(4):261-70
6130509
Pharmacol Ther. 1993 Jun;58(3):319-79
7504306
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17149-54
12486235
J Neurosci. 1999 Jan 15;19(2):511-9
9880571
J Neurosci. 2002 Mar 1;22(5):1648-67
11880495
J Neurosci. 1986 Mar;6(3):782-9
2870141
Curr Opin Neurobiol. 2009 Jun;19(3):245-53
19559598
J Physiol. 2008 Feb 15;586(4):1005-15
18063666
J Biol Chem. 2006 Aug 25;281(34):24204-15
16760467
Trends Neurosci. 2000 Feb;23(2):60-8
10652546
Nature. 1989 Nov 23;342(6248):433-5
2573839
Curr Opin Neurobiol. 2001 Jun;11(3):320-6
11399430
Bull Math Biol. 1991;53(4):537-55
1681970
J Physiol. 1985 Oct;367:163-81
2865362
Eur J Neurosci. 2006 Apr;23(8):2048-56
16630052
Science. 2010 Mar 26;327(5973):1614-8
20150444
J Neurophysiol. 1974 Jul;37(4):594-608
4837770
Annu Rev Neurosci. 1987;10:633-93
2436546
J Neurophysiol. 1990 Jan;63(1):173-80
2153771
J Physiol. 1997 Jun 1;501 ( Pt 2):251-62
9192298
J Neurosci. 1994 Oct;14(10):5885-902
7931551
J Physiol. 2001 Nov 1;536(Pt 3):717-25
11691867
Nature. 2006 Nov 2;444(7115):106-9
17065983
Neuron. 2003 Mar 6;37(5):801-11
12628170
J Biol Chem. 2002 Oct 25;277(43):40375-83
12177051
Proc Natl Acad Sci U S A. 2005 May 17;102(20):7368-73
15878995
Pflugers Arch. 1986 Feb;406(2):121-30
2421235
Nature. 2000 Aug 24;406(6798):889-93
10972290
Pflugers Arch. 1982 Oct;395(1):1-5
6129610
Prog Neurobiol. 1989;32(1):1-9
2563912
Neuron. 2008 Sep 25;59(6):882-901
18817729