Chaetoglocins A-D, four new metabolites from the endophytic fungus Chaetomium globosum.
Chaetoglocins A-D (1- 4), four new secondary metabolites, were isolated from the solid-fermentation culture of Chaetomium globosum (strain no. IFB-E036), an endophytic fungus residing inside the root of Cynodon dactylon. The structures of these compounds were elucidated on the basis of detailed spectroscopic evidence and by comparing spectroscopic data with those in the literature. Compounds 1 and 2 displayed antimicrobial activity against the gram-positive bacteria with minimum inhibitory concentrations (MIC) between 8 and 32 µg/mL.
Ge
Hui Ming
HM
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, P. R. China.
Zhang
Qiang
Q
Xu
Su Hai
SH
Guo
Zhi Kai
ZK
Song
Yong Chun
YC
Huang
Wu Yang
WY
Tan
Ren Xiang
RX
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D031744:Cynodon; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D038821:Mycorrhizae / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001688:Biological Products