title: Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study.
abstract: OBJECTIVE
  Cell therapy for stress urinary incontinence (SUI) management has been experienced with encouraging results.
  
  
  METHODS
  We conducted an open prospective study on 12 women presenting severe SUI with fixed urethra, after previous failed surgical management. Patients underwent intrasphincteric injections of autologous progenitor muscular cells isolated from a biopsy of deltoid muscle. Primary endpoint focused on safety (measurement of Q(max) variation after 3 months). Secondary endpoints assessed side effects and efficacy.
  
  
  RESULTS
  No variation was diagnosed on Q(max) measurements. Efficacy data show that three of 12 patients are dry at 12 months, seven other patients are improved on pad test but not on voiding diary, and two patients were slightly worsened by the procedure. Quality of life was improved in half of patients.
  
  
  CONCLUSIONS
  Cell therapy for severe multioperated cases of SUI is a mini-invasive, feasible, and safe procedure that can improve urinary condition in as a second line therapy.
authors.affiliation: Department of Urology, Tenon Hospital, Groupe Hospitalo-Universitaire EST, Assistance Publique-Hôpitaux de Paris, University Paris VI, 4 rue de la Chine, 75970, Paris Cedex 20, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sèbe
authors.forename: Christelle
authors.initials: C
authors.lastname: Doucet
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Cornu
authors.forename: Calin
authors.initials: C
authors.lastname: Ciofu
authors.forename: Pierre
authors.initials: P
authors.lastname: Costa
authors.forename: Sixtina Gil Diez
authors.initials: SG
authors.lastname: de Medina
authors.forename: Christian
authors.initials: C
authors.lastname: Pinset
authors.forename: Francois
authors.initials: F
authors.lastname: Haab
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D032446:Myoblasts / Q000637:transplantation*; D011446:Prospective Studies; D011788:Quality of Life; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000628:therapy*
references.citation: Eur Urol. 2007 Jan;51(1):67-74
references.pmid: 17014950
references.citation: Urology. 2004 Nov;64(5):1037-41
references.pmid: 15533514
references.citation: BJU Int. 2004 Jul;94 Suppl 1:8-13
references.pmid: 15139858
references.citation: Transplantation. 2003 Oct 15;76(7):1053-60
references.pmid: 14557752
references.citation: Eur Urol. 2003 Apr;43(4):391-404
references.pmid: 12667721
references.citation: N Engl J Med. 2008 Mar 6;358(10):1029-36
references.pmid: 18322284
references.citation: Lancet. 2001 Jan 27;357(9252):279-80
references.pmid: 11214133
references.citation: Neurourol Urodyn. 2003;22(4):264-8
references.pmid: 12808699
references.citation: Mol Ther. 2005 Dec;12(6):1130-41
references.pmid: 16125468
references.citation: Cell Transplant. 2007;16(6):563-77
references.pmid: 17912948
references.citation: Lancet. 2006 Jan 7;367(9504):57-67
references.pmid: 16399154
references.citation: Ann Intern Med. 2008 Mar 18;148(6):459-73
references.pmid: 18268288
references.citation: Neurourol Urodyn. 1993;12(2):131-7
references.pmid: 7920669
references.citation: J Urol. 2001 Jan;165(1):271-6
references.pmid: 11125423
references.citation: J Urol. 1996 Jul;156(1):3-17
references.pmid: 8648827
references.citation: Neurourol Urodyn. 2000;19(3):279-87
references.pmid: 10797585
references.citation: Cell Transplant. 2007;16(7):741-9
references.pmid: 18019363
references.citation: Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jun;19(6):881-3
references.pmid: 18204978
references.citation: J Urol. 2003 May;169(5):1662-9
references.pmid: 12686804
references.citation: Urology. 2003 Jan;61(1):37-49
references.pmid: 12559262
references.citation: Exp Gerontol. 2004 Sep;39(9):1259-65
references.pmid: 15489048