Expression of Dpp6 in mouse embryonic craniofacial development.
Dipeptidyl-peptidase-like protein 6 (DPP6), a member of the dipeptidyl aminopeptidase family, plays distinct roles in brain development, but its expression in embryonic craniofacial development is unknown. The expression pattern of Dpp6 in the maxillofacial region during mouse embryonic craniofacial development was analyzed by whole-mount in situ hybridization on sections and by real-time PCR analysis. Dpp6 expression was detected during mouse embryonic craniofacial development in embryos 11-13.5 days post-coitum (dpc). Real-time PCR showed high Dpp6 expression present in 11.5-13.5dpc, and this then decreased as development of maxillofacial region progressed. The expression pattern of Dpp6 suggests that Dpp6 may be involved in embryonic craniofacial development.
Du
Juan
J
Molecular Laboratory for Gene Therapy and Tooth Regeneration, Capital Medical University School of Stomatology, Beijing, PR China.
Fan
Zhipeng
Z
Ma
Xin
X
Gao
Yuanrong
Y
Wu
Yan
Y
Liu
Shuhong
S
Shen
Yan
Y
Fan
Ming
M
Wang
Songlin
S
D000818:Animals; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics*; D005145:Face / Q000196:embryology*; D017403:In Situ Hybridization; D008445:Maxillofacial Development; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012333:RNA, Messenger; C569992:DPP6 protein, mouse; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases