Searching for new strategies for the pharmacological treatment of chronic pain.
Chronic pain is poorly managed and represents a huge unmet medical need that affects humans globally. The traditional multifaceted drug regimens for controlling chronic pain are marginally effective, produce highly variable results and display for the most parts unacceptable side effects. Research efforts over the last decade have identified peroxynitrite (PN) as a critical signaling molecule in the development of pain. Targeting PN is a novel evidence-based approach to develop novel therapeutics for managing chronic pain.
Salvemini
Daniela
D
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA. salvemd@slu.edu
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D002908:Chronic Disease; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D016194:Receptors, N-Methyl-D-Aspartate; D030421:Peroxynitrous Acid
Arch Biochem Biophys. 2009 Apr 15;484(2):238-44
19017525
Neuroscience. 2002;111(2):389-97
11983324
Anticancer Drugs. 1995 Apr;6 Suppl 3:4-13
7606036
Pain. 2004 May;109(1-2):132-42
15082135
Cell Mol Life Sci. 2000 Oct;57(11):1489-92
11092442
Nat Rev Drug Discov. 2002 May;1(5):367-74
12120412
J Neurosci. 2008 Sep 17;28(38):9486-94
18799680
Nat Rev Drug Discov. 2003 Mar;2(3):175-6
12619637
Pain Med. 2001 Mar;2(1):8-14
15102312
Nat Rev Drug Discov. 2007 Aug;6(8):662-80
17667957
Curr Opin Investig Drugs. 2002 Mar;3(3):441-8
12054094
Life Sci. 2010 Apr 10;86(15-16):604-14
19576230
Trends Pharmacol Sci. 2009 Apr;30(4):194-202
19261337
Drugs. 2003;63(15):1549-63
12887262
J Clin Invest. 2006 Jan;116(1):4-15
16395396
Br J Pharmacol. 2003 Oct;140(3):445-60
14522841
J Pharmacol Exp Ther. 2004 Jun;309(3):869-78
14988418
Antioxid Redox Signal. 2010 Sep 15;13(6):877-918
20095865
Drug News Perspect. 1998 May;11(4):204-14
15616662