[Effect of H3R agonist, IMETIT on allergic rhinitis in guinea pigs].
OBJECTIVE
To discuss the treatment of H3R agonist, IMETIT, on the allergic rhinitis(AR) ,and the influence to mRNA of Substance P(SP) and Substance P Receptor (SP-R) in AR model of guinea pigs.


METHODS
The severity of AR was assessed by allergic symptoms (sneezing, nasal rubbing and nose blocking). The changes in the nasal mucosa were studied by pathological methods. The expression of SP positive cell was detected by immunohistochemistry, and the expression of SP-R mRNA was detected by reverse transcriptive polymerase chain reaction (RT-PCR).


RESULTS
Histamine H3R agonists, IMETIT can effectively improve the AR symptoms, sneezing, nasal itching, nasal congestion, reduce the pathological changes in the nasal mucosa, cut down the SP secretion and SP-R mRNA expression.


CONCLUSIONS
Histamine H3R agonist, IMETIT can effectively relieve the symptoms of AR in guinea pigs, which is related to reducing SP secretion and SP-R mRNA expression.
Yang
Xudong
X
Xuzhou Medical College, Xuzhou, 221002, China.
Sun
Guangming
G
Xu
Xuegu
X
Li
Peihua
P
Liu
Wen
W
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D018100:Receptors, Histamine H3 / Q000187:drug effects; D018040:Receptors, Neurokinin-1 / Q000235:genetics / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D007093:Imidazoles; D018100:Receptors, Histamine H3; D018040:Receptors, Neurokinin-1; D013373:Substance P; C077430:imetit; D013890:Thiourea