title: Low DHA and plasmalogens associated with a precise PUFA-rich diet devoid of DHA.
abstract: OBJECTIVE
  Fatty acids, being multi-functional and partially diet-dependent, are crucial for health yet optimal dietary composition remains controversial. Previous work suggests that nutritionally-dependent populations live with significant fatty acid abnormalities despite abundant polyunsaturated fatty acid intake.
  
  
  METHODS
  An analysis of fasting plasma phospholipids, including plasmalogens, and total fatty acids was conducted on twelve tube-fed people receiving a uniform diet which meets current polyunsaturated fatty acid intake recommendations, specifically, linoleic acid as 8.1% of energy and alpha-linolenic acid as 1.3% of energy for at least two years.
  
  
  RESULTS
  Eicosapentaenoic- and docosahexaenoic acid-related phospholipids were low. In addition, C16:0- and C18:0-related plasmalogens, components of phospholipids, were low. Essential fatty acid deficiency as classically defined was not present.
  
  
  CONCLUSIONS
  Based upon extensive clinical investigations in neuro-typical people, abnormalities of these key cell-membrane components may have undesirable clinical consequences. In particular, docosahexaenoic acid sufficiency needs to be assured. Comprehensive re-evaluation of current recommendations may be necessary.
authors.affiliation: Department of Pediatrics, University of Wisconsin, USA. norris.glick@dhs.wisconsin.gov
authors.forename: Norris R
authors.initials: NR
authors.lastname: Glick
authors.forename: Milton H
authors.initials: MH
authors.lastname: Fischer
mesh_terms: D000328:Adult; D000368:Aged; D004032:Diet; D004281:Docosahexaenoic Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D010955:Plasmalogens / Q000097:blood*
chemical_list: D010743:Phospholipids; D010955:Plasmalogens; D004281:Docosahexaenoic Acids