The use of FDG-PET to target tumors by radiotherapy.
Fluorodeoxyglucose positron emission tomography (FDG-PET) plays an increasingly important role in radiotherapy, beyond staging and selection of patients. Especially for non-small cell lung cancer, FDG-PET has, in the majority of the patients, led to the safe decrease of radiotherapy volumes, enabling radiation dose escalation and, experimentally, redistribution of radiation doses within the tumor. In limited-disease small cell lung cancer, the role of FDG-PET is emerging. For primary brain tumors, PET based on amino acid tracers is currently the best choice, including high-grade glioma. This is especially true for low-grade gliomas, where most data are available for the use of (11)C-MET (methionine) in radiation treatment planning. For esophageal cancer, the main advantage of FDG-PET is the detection of otherwise unrecognized lymph node metastases. In Hodgkin's disease, FDG-PET is essential for involved-node irradiation and leads to decreased irradiation volumes while also decreasing geographic miss. FDG-PET's major role in the treatment of cervical cancer with radiation lies in the detection of para-aortic nodes that can be encompassed in radiation fields. Besides for staging purposes, FDG-PET is not recommended for routine radiotherapy delineation purposes. It should be emphasized that using PET is only safe when adhering to strictly standardized protocols.
Lammering
Guido
G
MAASTRO Clinic, Radiation Oncology, Maastricht, The Netherlands. guido.lammering@maastro.nl
De Ruysscher
Dirk
D
van Baardwijk
Angela
A
Baumert
Brigitta G
BG
Borger
Jacques
J
Lutgens
Ludy
L
van den Ende
Piet
P
Ollers
Michel
M
Lambin
Philippe
P
D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000532:radiotherapy; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1394-401
18258380
Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):329-36
19782478
J Nucl Med. 1991 Apr;32(4):610-5
2013801
Radiology. 1993 Jan;186(1):45-53
8380108
Int J Radiat Oncol Biol Phys. 2005 Mar 1;61(3):649-55
15708242
Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):511-9
16168843
Lancet. 2002 Apr 20;359(9315):1388-93
11978336
Strahlenther Onkol. 2008 Oct;184(10):536-42
19016044
Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):456-65
18556143
Eur J Nucl Med Mol Imaging. 2007 Apr;34(4):453-62
17058078
Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):392-9
19646825
Radiology. 2004 Oct;233(1):93-100
15317953
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):771-8
17398018
J Clin Oncol. 1999 Mar;17(3):894-901
10071281
Ann Surg Oncol. 2003 Oct;10(8):954-60
14527917
Strahlenther Onkol. 2009 Apr;185(4):260-5
19370430
Strahlenther Onkol. 2006 Jul;182(7):369-75
16826354
Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):155-62
17707268
Eur J Nucl Med Mol Imaging. 2008 Nov;35(11):1989-99
18661128
Radiology. 1998 Mar;206(3):755-60
9494497
Radiat Oncol. 2008 Dec 24;3:44
19108742
Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):339-44
16765533
Radiother Oncol. 2010 May;95(2):203-8
20176406
Int J Radiat Oncol Biol Phys. 2005 Mar 15;61(4):1123-8
15752892
Haematologica. 2006 Apr;91(4):522-9
16585017
Radiother Oncol. 2009 Jun;91(3):386-92
19329207
Blood. 2007 Jan 15;109(2):486-91
17003382
Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):126-34
16904518
Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):222-7
16488553
Blood. 2008 Nov 15;112(10):3989-94
18757777
J Nucl Med. 2002 Dec;43(12):1667-73
12468518
Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1461-9
19419820
Radiother Oncol. 2007 Nov;85(2):178-86
17719110
Strahlenther Onkol. 2008 Sep;184(9):457-64
19016024
J Nucl Med. 2007 Apr;48(4):519-27
17401087
Head Neck. 2008 Apr;30(4):471-8
18023031
Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):103-11
18632217
Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):267-75
17707281
Int J Radiat Oncol Biol Phys. 2000 Aug 1;48(1):43-52
10924970
Acta Neurochir Suppl. 2004;91:1-7
15707021
Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):340-5
16168829
Strahlenther Onkol. 2008 Aug;184(8):406-10
18956517
J Nucl Med. 2004 Jul;45(7):1146-54
15235060
J Nucl Med. 2003 Nov;44(11):1784-8
14602860
Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1385-92
15817341
Eur J Haematol Suppl. 2005 Jul;(66):90-7
16007875
J Nucl Med. 2005 Dec;46(12):1948-58
16330557
Br J Surg. 2007 Dec;94(12):1515-20
17902092
Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1161-7
18440729
Gynecol Oncol. 2002 Oct;87(1):90-7
12468348
J Nucl Med. 2004 Jun;45(6):980-7
15181133
Radiother Oncol. 2005 Oct;77(1):5-10
16019093
Semin Oncol. 2005 Feb;32(1 Suppl 1):S11-8
15786021
J Nucl Med. 2003 Oct;44(10):1644-8
14530480
Nuklearmedizin. 1999;38(8):312-8
10615664
J Nucl Med. 1998 May;39(5):778-85
9591574
Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):988-94
15989999
Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1397-402
18374225
Radiother Oncol. 2004 Dec;73(3):269-75
15588870
Radiother Oncol. 2006 Nov;81(2):209-25
17064802
Radiother Oncol. 2006 Jun;79(3):270-7
16797755
J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1457-62
15377696
Gynecol Oncol. 2007 Jul;106(1):29-34
17482666
J Nucl Med. 2001 Nov;42(11):1596-604
11696627
J Neurosurg. 2004 Nov;101 Suppl 3:381-9
15537193
Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1402-7
18234432
Radiother Oncol. 2010 Feb;94(2):151-5
20116114
J Clin Oncol. 2000 Sep 15;18(18):3202-10
10986052
Int J Radiat Oncol Biol Phys. 1998 Jul 15;41(5):989-95
9719107
Int J Radiat Oncol Biol Phys. 2002 Feb 1;52(2):339-50
11872279
Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):435-48
16198064
Cancer. 2006 Feb 15;106(4):914-22
16411226
Eur J Nucl Med Mol Imaging. 2005 Jan;32(1):39-51
15309329
J Nucl Med. 2007 May;48(5):720-5
17475959
Eur J Nucl Med Mol Imaging. 2008 Dec;35(12):2320-33
18704407
Int J Radiat Oncol Biol Phys. 2001 Jun 1;50(2):287-93
11380213
Radiother Oncol. 2009 Apr;91(1):95-100
19285354
Radiother Oncol. 2006 Mar;78(3):254-61
16545881
Cancer. 2005 Dec 1;104(11):2484-91
16270319
Radiother Oncol. 2004 May;71(2):139-46
15110446
Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):853-63
14529793