title: Opening of DNA double helix at room temperature: Application of alpha-cyclodextrin self-aggregates.
abstract: Self-aggregation of alpha-cyclodextrin (alpha-CD) can induce DNA opening at room temperature (25 degrees C) owing to the hydroxyl groups on the surface of the spherical aggregates of alpha-CD, which promote hydrogen bonding with the flipped-out bases in DNA duplex prohibiting them from reverting back.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, 741252, WB, India.
authors.forename: Syed S
authors.initials: SS
authors.lastname: Jaffer
authors.forename: Prasun
authors.initials: P
authors.lastname: Ghosh
authors.forename: Anindita
authors.initials: A
authors.lastname: Das
authors.forename: Pradipta
authors.initials: P
authors.lastname: Purkayastha
mesh_terms: D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D013696:Temperature; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D047391:alpha-Cyclodextrins; D004247:DNA; C032613:alpha-cyclodextrin