[Current models of thrombopoiesis].
Platelets are essential corpuscular blood components required for hemostasis. They are released from precursor cells in the bone marrow by cellular fragmentation into the blood stream. Although some aspects of platelet biogenesis are well known, studying its occurrence in vivo has been mostly unsatisfactory. This article reviews some recent findings: It first introduces current models of thrombopoiesis including open questions on cell biology. Second, it presents current findings on the release of megakaryocytes over the endothelial barrier into the blood stream where platelet production takes place outside the bone marrow. Finally, it reports on the translation of the more basic science into an improved understanding of novel parameters from automated blood counters surveying platelet volume (MPV), distribution width (PDW), mass (PCT) and the immature platelet fraction (IPF) into clinics where platelet counts are often the only accessible parameter to evaluate the risk of bleeding. Combining the comprehension of these parameters with a more refined image of how and where platelets are born might help find the cause and best therapy when platelet counts are low.
Schulze
H
H
Labor für Pädiatrische Molekularbiologie, Klinik für Allgemeine Pädiatrie, Otto-Heubner Centrum für Kinder- und Jugendmedizin, Ziegelstr. 5-9, 10098 Berlin. harald.schulze@charite.de
D001792:Blood Platelets / Q000166:cytology; D001854:Bone Marrow Cells / Q000166:cytology; D003585:Cell Biology; D048429:Cell Size; D004730:Endothelium, Vascular / Q000166:cytology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology; D010976:Platelet Count; D034061:Thrombopoiesis / Q000502:physiology*
Am J Hematol. 1978;4(4):303-12
717392
Br J Haematol. 2006 Sep;134(5):453-66
16856888
Blood. 1965 Dec;26(6):720-31
5844145
Blood. 1995 Jan 15;85(2):402-13
7529062
Blood. 2008 Feb 1;111(3):981-6
18223171
Scand J Haematol. 1971;8(3):223-30
5094000
Blood. 1995 Jul 15;86(2):419-31
7605981
Blood. 2005 Dec 15;106(13):4066-75
16118320
Int J Hematol. 2008 Oct;88(3):255-267
18751873
Curr Opin Hematol. 2007 Sep;14(5):419-26
17934346
Platelets. 2006 Nov;17(7):435-40
17074718
Eur J Haematol Suppl. 1998;61:3-23
9658684
Acta Anat (Basel). 1957;29(3):267-90
13434640
Blood. 2002 Aug 15;100(4):1310-7
12149212
Blood. 1998 Sep 1;92(5):1608-16
9716588
J Clin Invest. 2005 Dec;115(12):3348-54
16322779
J Exp Med. 1937 Jan 31;65(2):177-203
19870594
Semin Hematol. 2006 Jan;43(1 Suppl 1):S94-100
16427392
Clin Chem. 1997 Jun;43(6 Pt 1):1072-6
9191563
Blood. 2010 May 6;115(18):3801-9
20086251
Blood. 2008 May 1;111(9):4605-16
18230754
J Thromb Haemost. 2007 Jul;5 Suppl 1:318-27
17635743
Blood. 2006 May 15;107(10):3868-75
16434494
J Cell Biol. 1999 Dec 13;147(6):1299-312
10601342
Blood. 1982 Jul;60(1):213-9
7082839
Br J Haematol. 2004 Jul;126(1):93-9
15198738
Nat Med. 2004 Jan;10(1):64-71
14702636
J Biol Chem. 2008 May 16;283(20):14109-19
18347012
Vet Clin Pathol. 2008 Sep;37(3):266-71
18761517
Scand J Haematol. 1978 Nov;21(5):369-75
734350
Science. 2007 Sep 21;317(5845):1767-70
17885137