title: The persistent challenge of lupus nephritis.
abstract: Systemic lupus erythematosus has long been considered the prototypic autoimmune disease. Although the etiology remains enigmatic, there has been vigorous definition of the clinical features and the natural history. In this issue, we review the persistent challenge of lupus nephritis and, in particular, features of diagnosis as well as treatment options. It is clear that major therapeutic advances have occurred but there is still a considerable unmet need in the population. This issue does not review all the clinical problems of lupus nephritis, but rather attempts to place the most recent data in perspective for the clinician.
authors.affiliation: Reumatologia, Dipartimento di Clinica e Terapia Medica, Sezione di Reumatologia, Sapienza Università di Roma, V.le del Policlinico 155, 00161, Rome, Italy. guido.valesini@uniroma1.it
authors.forename: Guido
authors.initials: G
authors.lastname: Valesini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Conti
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D015551:Autoimmunity; D015415:Biomarkers / Q000378:metabolism; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D008181:Lupus Nephritis / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D019653:Myeloablative Agonists / Q000627:therapeutic use; D012074:Remission Induction; D000069283:Rituximab; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058846:Antibodies, Monoclonal, Murine-Derived; D015415:Biomarkers; D019653:Myeloablative Agonists; D051193:Toll-Like Receptors; D000069283:Rituximab; D003520:Cyclophosphamide; D009173:Mycophenolic Acid
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