Chlamydia trachomatis and cervical intraepithelial neoplasia in married women in a Middle Eastern community.
The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia (CIN). Data were collected in a case-control study for 60 patients with CIN in biopsy and 85 control subjects with normal colposcopy and biopsy. Serum antibodies to C trachomatis were associated with an increased risk for CIN [odds ratio (OR) = 7.3; 95% confidence interval (CI) 1.5-35.2)]. There was also a significant association between presence of inclusion bodies for C. trachomatis and CIN (OR = 5.5; 95% CI 2.4-12.4). These results indicate a strong association between CIN and chlamydial cervicitis.
Valadan
M
M
Department of Obstetrics and Gynaecology, Mirza Koochak Khan Hospital, Islamic Republic of Iran. mehrnaz_valadan@yahoo.com
Yarandi
F
F
Eftekhar
Z
Z
Danvish
S
S
Fathollahi
M S
MS
Mirsalehian
A
A
D000328:Adult; D000368:Aged; D001706:Biopsy; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002690:Chlamydia Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002692:Chlamydia trachomatis; D003127:Colposcopy; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D014623:Vaginal Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*