title: Burden of human papillomavirus infection and related comorbidities in men: implications for research, disease prevention and health promotion among Hispanic men.
abstract: Genital human papillomavirus (HPV) infection is one of the most commonly diagnosed sexually transmitted infections world-wide. Over the last two decades, research has established a strong causal link between specific types of HPV infection and cancer, particularly cervical, anal, vulvar/vaginal, penile, and oropharyngeal cancer. Limited epidemiological studies of anogenital HPV infection have been conducted in Hispanic populations (including Puerto Rico), and population-based incidence and prevalence estimates of HPV infection among Hispanics are limited. Studies that evaluate knowledge and awareness of HPV among men are also scarce. With the world-wide introduction of two new prophylactic vaccines against high-risk HPVs causing cervical cancer, and the recent FDA approval of the quadrivalent vaccine in preventing genital warts in men, there is an urgency to determine the burden of HPV in Hispanic populations before vaccine programs are implemented on a widespread basis. Knowledge and acceptability of the vaccine prior to implementation of these programs are also necessary to allow a targeted assessment. This review article summarizes existing research on HPV infection and HPV-related morbidities in men, with a particular emphasis on Hispanic men in the United States and Puerto Rico. Three major areas are discussed: (1) genital warts, (2) HPV and related cancers and (3) biobehavioral and psychosocial factors related to HPV infection and vaccination. Specific recommendations for advancing HPV research and knowledge among Hispanic populations also are suggested.
authors.affiliation: Center for Evaluation and Sociomedical Research, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico. vivian.colon@upr.edu
authors.forename: Vivian
authors.initials: V
authors.lastname: Colón-López
authors.forename: Ana P
authors.initials: AP
authors.lastname: Ortiz
authors.forename: Joel
authors.initials: J
authors.lastname: Palefsky
mesh_terms: D035843:Biomedical Research; D017281:Cost of Illness; D006293:Health Promotion; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000517:prevention & control* / Q000523:psychology / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000517:prevention & control* / Q000523:psychology
references.citation: J Adolesc Health. 2010 Apr;46(4 Suppl):S12-9
references.pmid: 20307839
references.citation: BMC Cancer. 2009 Apr 28;9:129
references.pmid: 19400958
references.citation: Semin Cancer Biol. 2004 Dec;14(6):453-71
references.pmid: 15489139
references.citation: J Community Health. 2000 Feb;25(1):67-78
references.pmid: 10706210
references.citation: Herpes. 2004 Apr;11(1):8-11
references.pmid: 15115631
references.citation: Am J Public Health. 2002 Mar;92(3):378-81
references.pmid: 11867314
references.citation: Public Health Genomics. 2009;12(5-6):291-307
references.pmid: 19684442
references.citation: Int J Cancer. 2006 Oct 15;119(8):1934-9
references.pmid: 16708372
references.citation: J Infect Dis. 2010 May 1;201(9):1340-3
references.pmid: 20350160
references.citation: Br J Cancer. 2001 Jul 6;85(1):46-54
references.pmid: 11437401
references.citation: CA Cancer J Clin. 2003 Jan-Feb;53(1):5-26
references.pmid: 12568441
references.citation: Gynecol Oncol. 2007 Nov;107(2 Suppl 1):S2-5
references.pmid: 17938014
references.citation: J Natl Cancer Inst. 2005 Jun 15;97(12):896-905
references.pmid: 15956651
references.citation: Cancer. 2008 Nov 15;113(10 Suppl):2892-900
references.pmid: 18980293
references.citation: Perspect Sex Reprod Health. 2004 Jan-Feb;36(1):6-10
references.pmid: 14982671
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Mar;99(3):311-5
references.pmid: 15716837
references.citation: Genitourin Med. 1997 Jun;73(3):174-80
references.pmid: 9306896
references.citation: Sex Transm Dis. 2007 Jul;34(7):479-84
references.pmid: 17413536
references.citation: J Natl Cancer Inst. 2009 Aug 19;101(16):1120-30
references.pmid: 19648510
references.citation: Arch Otolaryngol Head Neck Surg. 2009 Feb;135(2):180-8
references.pmid: 19221247
references.citation: Vaccine. 2008 Aug 19;26 Suppl 10:K17-28
references.pmid: 18847554
references.citation: J Pediatr Adolesc Gynecol. 2009 Aug;22(4):205-15
references.pmid: 19646665
references.citation: JAMA. 2004 Jul 14;292(2):171-9
references.pmid: 15249566
references.citation: N Engl J Med. 2002 Apr 11;346(15):1105-12
references.pmid: 11948269
references.citation: Sex Transm Dis. 2001 May;28(5):277-80
references.pmid: 11354266
references.citation: J Infect Dis. 2005 Feb 1;191 Suppl 1:S42-54
references.pmid: 15627230
references.citation: Dis Markers. 2007;23(4):261-72
references.pmid: 17627061
references.citation: Gynecol Oncol. 2010 May;117(2 Suppl):S15-9
references.pmid: 20138345
references.citation: Int J STD AIDS. 2001 Apr;12(4):211-5
references.pmid: 11319969
references.citation: Infect Agent Cancer. 2010 May 14;5:10
references.pmid: 20470399
references.citation: Prev Med. 2007 Aug-Sep;45(2-3):107-14
references.pmid: 17628649
references.citation: J Natl Cancer Inst. 2003 Dec 3;95(23):1772-83
references.pmid: 14652239
references.citation: Int J Addict. 1990 Jun;25(6):665-91
references.pmid: 2265869
references.citation: AIDS. 2008 Jun 19;22(10):1203-11
references.pmid: 18525266
references.citation: J Infect Dis. 1997 Aug;176(2):353-61
references.pmid: 9237700
references.citation: Sex Transm Dis. 2009 Jan;36(1):58-62
references.pmid: 18830138
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1710-6
references.pmid: 16030106
references.citation: J Infect Dis. 2006 Oct 15;194(8):1044-57
references.pmid: 16991079
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1077-83
references.pmid: 19318438
references.citation: Vaccine. 2006 Aug 31;24 Suppl 3:S3/11-25
references.pmid: 16949997
references.citation: Am J Obstet Gynecol. 2008 May;198(5):500.e1-7
references.pmid: 18455524
references.citation: Int J Epidemiol. 2010 Feb;39(1):166-81
references.pmid: 20022926
references.citation: Sex Transm Dis. 2008 Apr;35(4):357-60
references.pmid: 18360316
references.citation: Cancer. 2008 Nov 15;113(10 Suppl):2883-91
references.pmid: 18980292
references.citation: Lancet Oncol. 2010 Aug;11(8):781-9
references.pmid: 20451455
references.citation: Ethn Health. 2009 Dec;14(6):607-24
references.pmid: 19953392
references.citation: Cir Cir. 2007 May-Jun;75(3):151-5
references.pmid: 17659164
references.citation: Vaccine. 2008 Aug 19;26 Suppl 10:K53-61
references.pmid: 18847557
references.citation: P R Health Sci J. 2011 Jun;30(2):65-8
references.pmid: 21682148
references.citation: Head Neck. 2004 Sep;26(9):778-84
references.pmid: 15350023
references.citation: Oral Oncol. 2000 Jan;36(1):106-15
references.pmid: 10889929
references.citation: Cancer Causes Control. 1999 Feb;10(1):27-33
references.pmid: 10334639
references.citation: J Dent Res. 2009 Apr;88(4):300-6
references.pmid: 19407148
references.citation: Br J Cancer. 2002 Mar 4;86(5):705-11
references.pmid: 11875730
references.citation: Curr Opin HIV AIDS. 2009 Jan;4(1):52-6
references.pmid: 19339939
references.citation: Sex Transm Infect. 2010 Jun;86(3):241-6
references.pmid: 19951936
references.citation: Contraception. 2009 Aug;80(2):158-62
references.pmid: 19631791
references.citation: Int J Cancer. 2009 Mar 15;124(6):1251-7
references.pmid: 19089913
references.citation: Cancer. 2008 Nov 15;113(10 Suppl):2901-9
references.pmid: 18980273
references.citation: Arch Med Res. 2008 Feb;39(2):189-97
references.pmid: 18164962
references.citation: Epidemiol Rev. 2004;26:22-35
references.pmid: 15234945
references.citation: J Infect Dis. 2009 May 1;199(9):1263-9
references.pmid: 19320589
references.citation: Sex Transm Dis. 2004 Oct;31(10):601-7
references.pmid: 15388997
references.citation: Gynecol Oncol. 2007 Nov;107(2 Suppl 1):S24-6
references.pmid: 17938015
references.citation: Cancer. 2007 Oct 1;110(7):1429-35
references.pmid: 17724670
references.citation: Sex Transm Infect. 2002 Jun;78(3):215-8
references.pmid: 12238658
references.citation: Clin Infect Dis. 2002 Nov 1;35(9):1127-34
references.pmid: 12384848
references.citation: J Am Board Fam Med. 2009 Jan-Feb;22(1):34-42
references.pmid: 19124631
references.citation: Sex Transm Dis. 2010 Jun;37(6):386-91
references.pmid: 20081557
references.citation: Int J STD AIDS. 2005 Oct;16(10):667-70
references.pmid: 16212712
references.citation: J Infect Dis. 2009 Apr 1;199(7):965-73
references.pmid: 19239366
references.citation: J Infect Dis. 2009 Feb 1;199(3):362-71
references.pmid: 19133808
references.citation: J Infect Dis. 2003 Apr 1;187(7):1064-70
references.pmid: 12660920
references.citation: Int J Cancer. 2006 Jun 15;118(12):3030-44
references.pmid: 16404738
references.citation: Braz J Otorhinolaryngol. 2006 Mar-Apr;72(2):272-82
references.pmid: 16951865
references.citation: P R Health Sci J. 2010 Sep;29(3):241-9
references.pmid: 20799511