Inhibitory effects of acylated acyclic sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor-alpha-induced cytotoxicity.
Four new acylated acyclic sesquiterpene oligoglycosides (1-4) were isolated from the pericarps of Sapindus rarak DC. together with four known acyclic sesquiterpene oligoglycosides, mukuroziosides Ia (5), Ib (6), IIa (7), and IIb (8). Their structures were elucidated on the basis of chemical and physicochemical evidence. These newly isolated compounds (1-4) were found to show inhibitory effects on tumor necrosis factor-alpha-induced cytotoxicity in L929 cells at concentrations of 30-100 microM.
Morikawa
Toshio
T
Pharmaceutical Research and Technology Institute, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Xie
Yuanyuan
Y
Ninomiya
Kiyofumi
K
Okamoto
Masaki
M
Muraoka
Osamu
O
Yuan
Dan
D
Yoshikawa
Masayuki
M
Hayakawa
Takao
T
D000215:Acylation; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D032127:Sapindus / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*
D003603:Cytotoxins; D006027:Glycosides; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha