title: Microarray analysis of temperature-induced transcriptome of Streptococcus suis serotype 2.
abstract: Streptococcus suis serotype 2 (S. suis S2) is able to cause human infections ranging from superficial wounded skin infections to severe invasive infections such as meningitis and streptococcal toxic shock-like syndrome. During its infection cycle, S. suis S2 must acclimatize itself to temperature shift. Herein, a whole-genome DNA microarray was used to investigate the global transcriptional regulation of an invasive strain of S. suis S2 grown to late-exponential phase at 29°C or 40°C relative to 37°C. The differentially regulated genes that were detected included those encoding virulence factors, antigenic proteins, ATP-binding-cassette transporters, and proteins of unknown functions. Our data provided a global profile of gene transcription induced by temperature alteration and shed light on some unforeseen lines for further pathogenesis investigation.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China.
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Zeng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Yuling
authors.initials: Y
authors.lastname: Zheng
authors.forename: Zhaobiao
authors.initials: Z
authors.lastname: Guo
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Tang
authors.forename: Ruifu
authors.initials: R
authors.lastname: Yang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Zhou
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D015536:Down-Regulation; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012329:RNA, Bacterial / Q000235:genetics; D013290:Streptococcal Infections / Q000382:microbiology*; D017011:Streptococcus suis / Q000145:classification / Q000235:genetics* / Q000502:physiology; D013696:Temperature; D059467:Transcriptome / Q000235:genetics*; D015854:Up-Regulation; D037521:Virulence Factors / Q000235:genetics
chemical_list: D012329:RNA, Bacterial; D037521:Virulence Factors