title: The association between conventional antidepressants and the metabolic syndrome: a review of the evidence and clinical implications.
abstract: Major depressive disorder is a prevalent recurrent medical syndrome associated with inter-episodic dysfunction. The metabolic syndrome is comprised of several established risk factors for cardiovascular disease (i.e. abdominal obesity, dyslipidaemia, dysglycaemia and hypertension). The criterion items of the metabolic syndrome collectively represent a multi-dimensional risk factor for cardiovascular disease and type 2 diabetes mellitus. Extant evidence indicates that both major depressive disorder and the metabolic syndrome, albeit distinct, often co-occur and are possibly subserved by overlapping pathophysiology and causative mechanisms. Conventional antidepressants exert variable effects on constituent elements of the metabolic syndrome, inviting the need for careful consideration prior to treatment selection and sequencing. Initiating and maintaining antidepressant therapy should include routine surveillance for clinical and/or biochemical evidence suggestive of the metabolic syndrome.
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. roger.mcintyre@uhn.on.ca
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
authors.forename: Ka Young
authors.initials: KY
authors.lastname: Park
authors.forename: Candy W Y
authors.initials: CW
authors.lastname: Law
authors.forename: Farah
authors.initials: F
authors.lastname: Sultan
authors.forename: Amanda
authors.initials: A
authors.lastname: Adams
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Lourenco
authors.forename: Aaron K S
authors.initials: AK
authors.lastname: Lo
authors.forename: Joanna K
authors.initials: JK
authors.lastname: Soczynska
authors.forename: Hanna
authors.initials: H
authors.lastname: Woldeyohannes
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alsuwaidan
authors.forename: Jinju
authors.initials: J
authors.lastname: Yoon
authors.forename: Sidney H
authors.initials: SH
authors.lastname: Kennedy
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D018687:Antidepressive Agents, Second-Generation
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