Stress and use of over-the-counter analgesics: prevalence and association among Danish 25 to 44-year-olds from 1994 to 2005.
OBJECTIVE
To examine the prevalence of over-the-counter analgesic (OTCA) use and perceived stress among 25 to 44-year-old men and women from 1994 to 2005; to examine the association between stress and OTCA use over time, and to explore whether the association attenuates when controlled by stress-related symptoms.


METHODS
Cross-sectional studies were carried out in 1994, 2000 and 2005. The study population included men and women from ages 25 to 44 years (n (1994) = 1,781, n (2000) = 5,819, n (2005) = 4,831). The surveys were conducted by face-to-face interviews and the outcome measure was OTCA use. The independent variable was perceived stress and pain/discomfort symptoms were included as covariates.


RESULTS
There was a significant increase in OTCA use and often feeling stressed from 1994 to 2005. Although there was a significant association between stress and OTCA use for men in all three surveys, there was no association in 2000 when adjusted for symptoms. For women stress and OTCA use were not associated in 1994, while in 2000 and 2005 the association was significant, also after adjusting for symptoms.


CONCLUSIONS
The findings indicate that there may be an increasing overuse of OTCA in treating stress among 25 to 44-year-old men and women.
Koushede
Vibeke
V
Section for Social Pharmacy, Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Science, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark. vik@farma.ku.dk
Ekholm
Ola
O
Holstein
Bjørn E
BE
Andersen
Anette
A
Hansen
Ebba Holme
EH
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage* / Q000600:supply & distribution; D003430:Cross-Sectional Studies; D003718:Denmark; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D015995:Prevalence; D012737:Sex Factors; D013315:Stress, Psychological / Q000150:complications / Q000453:epidemiology*
D000700:Analgesics
J Am Coll Health. 2008 Mar-Apr;56(5):535-47
18400666
Scand J Work Environ Health. 2003 Dec;29(6):444-51
14712852
Ugeskr Laeger. 2009 Jan 5;171(1-2):24-8
19128560
Int J Epidemiol. 1994 Dec;23(6):1262-72
7721530
J Headache Pain. 2009 Jun;10(3):177-85
19326184
Pain. 2005 Jun;115(3):374-381
15911164
Soc Sci Med. 1994 Jan;38(2):373-81
8140464
Scand J Public Health. 2009 Sep;37(7):758-65
19622549
Am J Epidemiol. 2008 Sep 1;168(5):481-91; discussion 492-6
18611955
Mil Med. 2006 Aug;171(8):710-6
16933810
Annu Rev Clin Psychol. 2005;1:607-28
17716101
Eur J Public Health. 2005 Oct;15(5):528-35
16051660
J Adolesc Health. 2006 Sep;39(3):362-6
16919797
BMC Womens Health. 2004 Aug 25;4 Suppl 1:S29
15345092
Neurology. 2006 Jan 24;66(2):198-201
16434653
Prev Med. 1991 Mar;20(2):306-15
2057476
Ann Pharmacother. 1998 Apr;32(4):485-94
9562147
Qual Health Res. 2008 Feb;18(2):234-43
18216342
Scand J Public Health. 2008 Jun;36(4):369-79
18539691
J Psychiatry Neurosci. 1998 Jan;23(1):13-34
9505057
Soc Sci Med. 2002 Mar;54(5):767-82
11999492
Scand J Work Environ Health. 2006 Dec;32(6):473-81
17173203
Int J Behav Med. 1997;4(2):105-16
16250733
Pharmacoepidemiol Drug Saf. 2009 Jul;18(7):619-23
19358227
Pediatrics. 2007 Jul;120(1):110-7
17606568
Eur J Public Health. 2008 Apr;18(2):189-94
17984128
J Health Soc Behav. 1983 Jun;24(2):132-43
6886368
Pharmacoepidemiol Drug Saf. 2010 Apr;19(4):351-7
20014359
J Am Geriatr Soc. 1990 Sep;38(9):979-84
2212451