Neurogranin and synaptic plasticity balance.
Learning-related modifications of synaptic transmission at CA1 hippocampal excitatory synapses are activity- and NMDA receptor (NMDAR)-dependent. While a postsynaptic increase in Ca(2+) is absolutely required for synaptic plasticity induction, the molecular mechanisms underlying the transduction of synaptic signals to postsynaptic changes are not clearly understood. In our recent study, we found that the postsynaptic calmodulin (CaM)-binding protein neurogranin (Ng) enhances synaptic strength in an activity- and NMDAR-dependent manner. Furthermore we have shown that Ng is not only required for the induction of long-term potentiation (LTP), but its mediated synaptic potentiation also mimics and occludes LTP. Our results demonstrate that Ng plays an important role in the regulation of hippocampal synaptic plasticity and synaptic function. Here, we summarize our findings and further discuss their possible implications in aging-related synaptic plasticity deficits.
Zhong
Ling
L
Department of Cell Biology, Neurobiology and Anatomy; Medical College of Wisconsin; Milwaukee, WI USA.
Gerges
Nashaat Z
NZ
Science. 1992 May 22;256(5060):1199-202
1317063
Hippocampus. 1993 Jan;3(1):57-66
8364683
Neurosci Lett. 1995 Feb 6;185(1):1-4
7537357
Hippocampus. 1997;7(6):602-12
9443057
J Neurosci. 2001 Aug 15;21(16):6008-17
11487624
Science. 1999 Jun 11;284(5421):1811-6
10364548
Neuron. 1995 Aug;15(2):427-34
7646894
Hippocampus. 1997;7(5):549-58
9347351
J Neurosci. 2001 Aug 15;21(16):6423-9
11487666
EMBO J. 2009 Oct 7;28(19):3027-39
19713936
Nature. 1998 Jun 18;393(6686):695-8
9641681
J Neurosci. 2002 Jul 1;22(13):5525-35
12097504
Neuron. 2000 Mar;25(3):649-62
10774732
Acta Biomed. 2007;78 Suppl 1:58-66
17465325
Cold Spring Harb Symp Quant Biol. 1992;57:527-39
1339689
J Neurobiol. 1999 Oct;41(1):92-101
10504196
J Neurosci. 1990 Dec;10(12):3782-92
2269883
Science. 2000 Mar 24;287(5461):2262-7
10731148
J Biol Chem. 1994 Sep 2;269(35):22420-6
8071370
Nat Rev Neurosci. 2002 Mar;3(3):175-90
11994750
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14112-7
10570207
Nature. 1993 Jan 7;361(6407):31-9
8421494
Science. 1998 Feb 6;279(5352):870-3
9452388
Cell. 2001 Nov 30;107(5):617-29
11733061
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18212-6
15608060
Eur J Neurosci. 2000 Sep;12(9):3276-82
10998111
Nature. 1994 Jun 9;369(6480):486-8
7515479
J Neurosci. 1998 Nov 1;18(21):8863-74
9786992
Neuron. 2005 Jun 16;46(6):905-16
15953419
J Neurosci. 1996 Sep 1;16(17):5382-92
8757251
J Neurosci. 2004 Nov 24;24(47):10660-9
15564582
Neuron. 2000 Mar;25(3):635-47
10774731
Nat Neurosci. 2000 Dec;3(12):1291-300
11100150
J Mol Neurosci. 1994 Fall;5(3):133-48
7654517
Nature. 1995 Jun 1;375(6530):400-4
7760933
Neurobiol Aging. 1993 May-Jun;14(3):249-58
8321393
J Neurosci. 2001 Jun 1;21(11):4066-73
11356894
FASEB J. 1990 Apr 1;4(6):1567-76
2108074
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6270-3
293720
J Neurochem. 2001 Nov;79(4):859-67
11723178