Influence of deltamethrin on nonspecific cellular and humoral defense mechanisms in rainbow trout (Oncorhynchus mykiss).
The influence of deltamethrin on the innate immunity in rainbow trout was examined. Fish were immersed in deltamethrin at doses of 1, 2, and 4 microg/L for 30 min. The results showed that deltamethrin at doses of 2 and 4 microg/L decreased phagocytic activity of spleen macrophages and proliferative response of pronephros lymphocytes at days 1, 2, and 5 after immersion. Deltamethrin at these doses decreased the lysozyme activity, total protein, and immunoglobulin levels in serum. The greatest immunosuppressive influence of deltamethrin at dose 4 microg/L was observed at the end of the study.
Siwicki
Andrzej K
AK
Department of Infection Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn-Kortowo II, Poland. aksiw@infish.com.pl
Terech-Majewska
Elzbieta
E
Grudniewska
Joanna
J
Malaczewska
Joanna
J
Kazun
Krzysztof
K
Lepa
Agnieszka
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007113:Immunity, Innate / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009570:Nitriles / Q000633:toxicity*; D017686:Oncorhynchus mykiss / Q000276:immunology*; D011722:Pyrethrins / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014874:Water Pollutants, Chemical; C017180:decamethrin