2,2,2-Trifluoro-N-(1a,2,7,7a-tetrahydronaphtho[2,3-b]oxiren-3-yl)acetamide by X-ray powder diffraction.
The title compound, C(12)H(10)F(3)NO(2), an important precursor in the preparation of benzovesamicol analogues for the diagnosis of Alzheimer's disease, was prepared by the epoxidation of 5,8-dihydronaphthalen-1-amine using 3-chloroperoxybenzoic acid. The structure was determined by X-ray powder diffraction, multinuclear NMR spectroscopy and FT-IR spectroscopy. A pair of molecules form intermolecular N-H...O hydrogen bonds, involving the amino and oxirene groups, to produce a dimer.
Rukiah
Mwaffak
M
Department of Chemistry, Atomic Energy Commission of Syria (AECS), PO Box 6091, Damascus, Syrian Arab Republic. cscientific@aec.org.sy
Assaad
Thaer
T
D000081:Acetamides / Q000737:chemistry*; D019281:Dimerization; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
C552506:2,2,2-trifluoro-N-(1a,2,7,7a-tetrahydronaphtho(2,3-b)oxiren-3-yl)acetamide; D000081:Acetamides; D009281:Naphthalenes