The orbital fibroblast: a key player and target for therapy in graves' ophthalmopathy.
Orbital fibroblasts play a key role in the pathogenesis of Graves' ophthalmopathy (GO). We discuss some major aspects by which orbital fibroblasts contribute to GO and the important role of PDGF-BB herein. Finally, we propose the orbital fibroblast, and especially the PDGF system acting on orbital fibroblasts, as an important therapeutic target in GO.
van Steensel
Leendert
L
Department of Immunology, Erasmus MC, Rotterdam, the Netherlands.
Dik
Willem A
WA
D058846:Antibodies, Monoclonal, Murine-Derived / Q000494:pharmacology*; D000077214:Becaplermin; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D016503:Drug Delivery Systems; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D049970:Graves Ophthalmopathy / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D008297:Male; D009915:Orbit / Q000166:cytology / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000276:immunology / Q000378:metabolism*; D020574:Proto-Oncogene Proteins c-sis; D000069283:Rituximab; D012680:Sensitivity and Specificity
D058846:Antibodies, Monoclonal, Murine-Derived; D015415:Biomarkers; D016207:Cytokines; D007155:Immunologic Factors; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D000069283:Rituximab