Evaluation of a novel isotope biomarker for dietary consumption of sweets.
Carbon isotopic signatures ("δ¹³C") might reflect consumption of corn- and cane-based sweeteners. The authors hypothesized that the δ¹³C value of human serum is higher for individuals with high versus low intakes of corn- and cane-based sweeteners (measured as sweetened beverage intake). They conducted a cross-sectional study within the Atherosclerosis Risk in Communities Magnetic Resonance Imaging study (Maryland, 2005-2006). Diet was assessed by food frequency questionnaire, and blinded serum samples were assayed by natural abundance stable isotope mass spectroscopy. Studied were 186 participants (53% male; mean age, 71 years; mean body mass index, 30 kg/m²). Serum δ¹³C values for individuals with high sweetened beverage intakes were significantly higher than for those with low intakes (-19.15‰ vs. -19.47‰, P < 0.001). Serum δ¹³C value increased 0.20‰ for every serving/day of sweetened beverages (P < 0.01). The association between sweetened beverages and serum δ¹³C value remained significant after adjustment for confounding by corn-based product intake (P < 0.001). Serum δ¹³C values were also associated with waist circumference, body mass index, and waist-to-hip ratio. This study provides the first known evidence that the δ¹³C value of human serum differs between persons consuming low and high amounts of sweets. Within the proper framework, serum δ¹³C value could be developed into an objective biomarker promoting more reliable assessment of dietary sweets intake.
Yeung
Edwina H
EH
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Saudek
Christopher D
CD
Jahren
A Hope
AH
Kao
Wen Hong Linda
WH
Islas
Melissa
M
Kraft
Rebecca
R
Coresh
Josef
J
Anderson
Cheryl A M
CA
D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D050197:Atherosclerosis / Q000097:blood*; D001628:Beverages / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight; D002247:Carbon Isotopes; D003430:Cross-Sectional Studies; D004034:Diet Surveys; D019422:Dietary Sucrose / Q000097:blood*; D004219:District of Columbia / Q000453:epidemiology; D002149:Energy Intake; D005260:Female; D005504:Food Analysis / Q000379:methods; D005518:Food Preferences; D006801:Humans; D008297:Male; D008396:Maryland / Q000453:epidemiology; D008875:Middle Aged; D015596:Nutrition Assessment; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D011795:Surveys and Questionnaires; D013549:Sweetening Agents; D055105:Waist Circumference; D049629:Waist-Hip Ratio
D015415:Biomarkers; D002247:Carbon Isotopes; D019422:Dietary Sucrose; D013549:Sweetening Agents
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