HCV genotype distribution and possible transmission risks in Lahore, Pakistan.
OBJECTIVE
To investigate the prevalence of hepatitis C virus (HCV) genotypes and their association with possible transmission routes in the general population of Lahore, as the data exclusively related to this city is limited.


METHODS
Complete data regarding patient's history, possible route of infection and biochemical tests was collected from the public hospital for 1364 patients. SPSS version 16 windows software was used for data analysis by univariate and multivariate techniques.


RESULTS
Age range < or = 40 years showed high prevalence of HCV infection. HCV genotype 3a was dominant (55.9%), followed by 1a (23.6%), 4a (12.5%), 3b (3.2%), untypable (2.5%), 4b (1.2%) and mixed type (1.2%). Blood transfusion, dental surgery and barber shops were the main risk factors for HCV transmission. Genotype prevalence was independent of age (P = 0.971) and gender (P = 0.122) while risk factors showed a significant association with age (P = 0.000) and genotypes (P = 0.000). We observed an independent association of risk factors and genotype 3a, while patients with genotype 1 and 4 were mostly infected due to dental surgery blood transfusion and barber shops. Risk factors of intravenous drug use and sexual exposure were exclusively found in < or = 40 years age group.


CONCLUSIONS
An increase in genotypes 1a and 4a suggest migration of people, possibly from Balochistan and the northern war-zone area. Government should focus on public education regarding infection routes.
Ahmad
Waqar
W
Applied and Functional Genomics Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore 53700, Pakistan.
Ijaz
Bushra
B
Javed
Fouzia-Tahir
FT
Jahan
Shah
S
Shahid
Imran
I
Khan
Fawad-Mumtaz
FM
Hassan
Sajida
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification*; D006526:Hepatitis C / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D015819:Substance Abuse, Intravenous / Q000150:complications
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