Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations.
The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation traversing the European house mouse hybrid zone to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01 cM apart (that is, recombination is expected only once in 10 000 meioses), disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed. We conclude that studies on MHC genes in wild-living vertebrates can give substantially different results depending on the MHC gene examined and that the level of polymorphism in a related species is a poor criterion for gene choice.
Cížková
D
D
Department of Population Biology, Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic. dejsha@seznam.cz
Gouy de Bellocq
J
J
Baird
S J E
SJ
Piálek
J
J
Bryja
J
J
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016000:Cluster Analysis; D017931:DNA Primers / Q000235:genetics; D019143:Evolution, Molecular; D040461:Gene Components; D014644:Genetic Variation; D005828:Genetics, Population; D006824:Hybridization, Genetic; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D012641:Selection, Genetic; D016415:Sequence Alignment
D017931:DNA Primers
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