title: Quality of life and cognitive dysfunction in people with schizophrenia.
abstract: The main purpose of the present study was to examine the relationship between quality of life (QOL) and cognitive dysfunction in schizophrenia. Subjects were 61 stabilized outpatients. Quality of life and cognitive function were assessed using the Quality of Life Scale (QLS) and the Brief Assessment of Cognition in Schizophrenia (BACS), respectively. Clinical symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS). The BACS composite score and the BACS Verbal memory score were positively correlated with the QLS total score and two subscales. The BACS Attention and speed of information processing score had positive correlation with the QLS total and all the subscales scores. The PANSS Positive and Negative syndrome scores also had significant correlations with the QLS total score and all of the subscales. In addition, the CDSS score was negatively correlated with the QLS total score and some of the subscales. Stepwise regression analysis showed that the BACS Attention and speed of information processing score was an independent predictor of the QLS total score but it was less associated with the QLS than the PANSS Negative syndrome score and the CDSS score. The results suggest that negative and depressive symptoms are important factors on patients' QOL and also support the view that cognitive performance provides a determinant of QOL in patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Institute of Health Bioscience, The University of Tokushima Graduate School, Japan. y-aiueo@ktd.biglobe.ne.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ueoka
authors.forename: Masahito
authors.initials: M
authors.lastname: Tomotake
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kaneda
authors.forename: Kyoko
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Masahito
authors.initials: M
authors.lastname: Nakataki
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Shinya
authors.initials: S
authors.lastname: Tayoshi
authors.forename: Ken
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Satsuki
authors.initials: S
authors.lastname: Sumitani
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohmori
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012189:Retrospective Studies; D012559:Schizophrenia / Q000150:complications*; D011795:Surveys and Questionnaires; D055815:Young Adult