Can autophagy promote longevity?
Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.
Madeo
Frank
F
Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
Tavernarakis
Nektarios
N
Kroemer
Guido
G
D000375:Aging / Q000502:physiology; D000818:Animals; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000502:physiology; D031204:Caloric Restriction; D016922:Cellular Senescence / Q000502:physiology; D019610:Cytoprotection / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology; D007109:Immunity / Q000502:physiology; D008136:Longevity / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D017526:Receptor, IGF Type 1 / Q000235:genetics; D000077185:Resveratrol; D012441:Saccharomyces cerevisiae / Q000502:physiology; D020123:Sirolimus / Q000494:pharmacology; D056564:Sirtuin 1 / Q000235:genetics; D013095:Spermidine / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D013267:Stilbenes; D016159:Tumor Suppressor Protein p53; D017526:Receptor, IGF Type 1; D056564:Sirtuin 1; D000077185:Resveratrol; D013095:Spermidine; D020123:Sirolimus
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