Prediction of preeclampsia and delivery of small for gestational age babies based on a combination of clinical risk factors in high-risk women.
OBJECTIVE
To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women.


METHODS
Individual risk scores based on clinical risk factors were calculated using logistic regression and validated in 1687 women with obesity in first pregnancy, chronic hypertension, or previous preeclampsia.


RESULTS
The risk of preeclampsia varied from 7% in obese primiparae without hypertension to 30% when previous preeclampsia and chronic hypertension occurred together. A prediction model incorporating these risk factors had a sensitivity of 48 and 89% for preeclampsia delivered <34 weeks' gestation.


CONCLUSIONS
Multiple clinical risk factors increase the risk of preeclampsia and SGA.
Seed
Paul T
PT
Division of Reproduction and Endocrinology, St Thomas' Hospital, King's College London, London, UK. paul.seed@kcl.ac.uk
Chappell
Lucy C
LC
Black
Michael A
MA
Poppe
Katrina K
KK
Hwang
Yuan-Chun
YC
Kasabov
Nikola
N
McCowan
Lesley
L
Shennan
Andrew H
AH
Wu
Steven H
SH
Poston
Lucilla
L
North
Robyn A
RA
D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D005260:Female; D005544:Forecasting; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011225:Pre-Eclampsia / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D018570:Risk Assessment; D012307:Risk Factors; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins; D014810:Vitamin E; D001205:Ascorbic Acid