Parathelypteriside attenuates cognition deficits in d-galactose treated mice by increasing antioxidant capacity and improving long-term potentiation.
Parathelypteriside (PG), a stilbenoid compound, was extracted from Parathelypteris glanduligera (kze.) ching that exhibits antioxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effect of PG against the d-galactose (d-gal)-induced neurotoxicity in mice. It was found that long-term intraperitoneal (i.p.) injection of PG (5 or 10 mg/(kg day)) for two weeks significantly improved the behavioral performance of d-gal-treated mice in both Morris water maze test and step-down avoidance test. Biochemical examination revealed that PG reduced the increased levels of malondialdehyde (MDA), and attenuated the decreased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase in the hippocampus of d-gal-treated mice. Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB). Together, these results suggested that the natural product PG represented a potential source of medicine for the treatment of the neurodegenerative diseases.
Fu
Wei
W
Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, PR China.
Lei
Yong-Fang
YF
Chen
Jing-Lou
JL
Xiong
Chao-Mei
CM
Zhou
Dao-Nian
DN
Wu
Guang-Hua
GH
Chen
Jing
J
Cai
Ya-Ling
YL
Ruan
Jin-Lan
JL
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D015153:Blotting, Western; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004594:Electrophysiology; D005690:Galactose / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology* / Q000627:therapeutic use; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D017774:Long-Term Potentiation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D017382:Reactive Oxygen Species / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
D017362:Cyclic AMP Response Element-Binding Protein; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017382:Reactive Oxygen Species; D013267:Stilbenes; C555340:parathelypteriside; D008315:Malondialdehyde; D005690:Galactose