title: Amyloid Precursor Protein Binding Protein-1 Is Up-regulated in Brains of Tg2576 Mice.
abstract: Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of amyloid precursor protein and serves as a bipartite activation enzyme for the ubiquitin-like protein, NEDD8. Previously, it has been reported that APP-BP1 rescues the cell cycle S-M checkpoint defect in Ts41 hamster cells, that this rescue is dependent on the interaction of APP-BP1 with hUba3. The exogenous expression of APP-BP1 in neurons has been reported to cause DNA synthesis and apoptosis via a signaling pathway that is dependent on APP-BP1 binding to APP. These results suggest that APP-BP1 overexpression contributes to neurodegeneration. In the present study, we explored whether APP-BP1 expression was altered in the brains of Tg2576 mice, which is an animal model of Alzheimer's disease. APP-BP1 was found to be up-regulated in the hippocampus and cortex of 12 month-old Tg2576 mice compared to age-matched wild-type mice. In addition, APP-BP1 knockdown by siRNA treatment reduced cullin-1 neddylation in fetal neural stem cells, suggesting that APP-BP1 plays a role in cell cycle progression in the cells. Collectively, these results suggest that increased expression of APP-BP1, which has a role in cell cycle progression in neuronal cells, contributes to the pathogenesis of Alzheimer's disease.
authors.affiliation: Department of Food and Nutrition, Kookmin University College of Natural Sciences, Seoul 136-702, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Yang
authors.forename: Yuyoung
authors.initials: Y
authors.lastname: Joo
authors.forename: Bo-Hyun
authors.initials: BH
authors.lastname: Hong
authors.forename: Sung-Ji
authors.initials: SJ
authors.lastname: Ha
authors.forename: Ran-Sook
authors.initials: RS
authors.lastname: Woo
authors.forename: Sang Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Yoo-Hun
authors.initials: YH
authors.lastname: Suh
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Kim
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