Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism.
A 64-year-old Egyptian man who resides in the United States presented to the rheumatology clinic with 6 months history of episodic recurrent pauci--arthritis along with constitutional symptoms. His Mediterranean ancestry, anti-cyclic citrullinated peptide negativity, and cyclical palindromic rheumatism prompted an investigation for familial Mediterranean fever gene mutation. He was found to have heterozygous 694I gene mutation during MEFV analysis. He also met Liveneh 1 major and 1 minor criteria for the diagnosis of familial Mediterranean fever.
Patel
Nirupa J
NJ
Section of Rheumatology, Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA. nirujp@gmail.com
Karia
Vijay R
VR
Gedalia
Abraham
A
Espinoza
Luis R
LR
D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D015897:Comorbidity; D003598:Cytoskeletal Proteins / Q000235:genetics; D003937:Diagnosis, Differential; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010456:Peptides, Cyclic / Q000276:immunology*; D000071198:Pyrin
D000888:Antibodies, Anti-Idiotypic; D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D010456:Peptides, Cyclic; D000071198:Pyrin; C487763:cyclic citrullinated peptide