Phosphatase activity controls the ups and downs of cerebellar learning.
Investigations of the cellular substrate for cerebellar learning have focused largely on a single form of plasticity, kinase-dependent long-term depression (LTD). In this issue of Neuron, Schonewille et al. provide evidence that calcineurin, a protein phosphatase required for long-term potentiation (LTP) and other cellular processes, may be just as important.
Carey
Megan R
MR
Champalimaud Neuroscience Programme, Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, P-2780-156 Oeiras, Portugal. mcarey@ineurophd.org
Regehr
Wade G
WG