Extract of passion fruit (Passiflora edulis) seed containing high amounts of piceatannol inhibits melanogenesis and promotes collagen synthesis.
The effect of passion fruit, the fruit of Passiflora edulis , on melanin inhibition and collagen synthesis was studied using cultured human melanoma and fibroblast cells. Passion fruit was divided into three parts, rind (PF-R), pulp (PF-P), and seed (PF-S), and each part was extracted using 80% ethanol. The concentration of polyphenols was higher in PF-S than in PF-R or PF-P. Treatment of melanoma cells with PF-S led to inhibition of melanogenesis. In addition, the production of total soluble collagen was elevated in dermal fibroblast cells cultured in the presence of PF-S. PF-R and PF-P did not yield these effects. Furthermore, the removal of polyphenols from PF-S led to the abolishment of the effects described above. We discovered that piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is present in passion fruit seeds in large amounts and that this compound is the major component responsible for the PF-S effects observed on melanogenesis and collagen synthesis.
Matsui
Yuko
Y
Research Institute, Morinaga and Company, Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan.
Sugiyama
Kenkichi
K
Kamei
Masanori
M
Takahashi
Toshio
T
Suzuki
Tamio
T
Katagata
Yohtaro
Y
Ito
Tatsuhiko
T
D045744:Cell Line, Tumor; D003094:Collagen / Q000096:biosynthesis*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008543:Melanins / Q000096:biosynthesis*; D029598:Passiflora / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D013267:Stilbenes / Q000494:pharmacology*
D008543:Melanins; D010936:Plant Extracts; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene; D003094:Collagen