title: Age-related effects on cortical thickness patterns of the Rhesus monkey brain.
abstract: The Rhesus monkey is a useful model for examining age-related as well as other neurological and developmental effects on the brain, because of the extensive neuroanatomical homology to the human brain, the reduced occurrence of neurological diseases such as Alzheimer's disease, and the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. In this study, cortical thickness measurements based on a cortical surface modeling technique were applied for the first time to investigate cortical thickness patterns in the rhesus monkey brain, and were used to evaluate regional age related effects across a wide range of ages. Age related effects were observed in several cortical areas, in particular in the somato-sensory and motor cortices, where a robust negative correlation of cortical thickness with age was observed, similar to that found in humans. In contrast, results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions.
authors.affiliation: Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Bang-Bon
authors.initials: BB
authors.lastname: Koo
authors.forename: Steven P
authors.initials: SP
authors.lastname: Schettler
authors.forename: Donna E
authors.initials: DE
authors.lastname: Murray
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Killiany
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Rosene
authors.forename: Dae-Shik
authors.initials: DS
authors.lastname: Kim
authors.forename: Itamar
authors.initials: I
authors.lastname: Ronen
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000473:pathology*; D013003:Somatosensory Cortex / Q000473:pathology*
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