title: Systems biology of cell behavior.
abstract: Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation against experimental data. This chapter outlines a universal approach to systems biology that allows the linking of intracellular molecular machinery and cellular activity. This procedure is achieved by applying mathematical modeling to molecular modules of a cell in the light of systems biology techniques.
authors.affiliation: Systems Biology Lab, Department of Engineering, University of Leicester, Leicester, UK.
authors.forename: Najl V
authors.initials: NV
authors.lastname: Valeyev
authors.forename: Declan G
authors.initials: DG
authors.lastname: Bates
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Umezawa
authors.forename: Antonina N
authors.initials: AN
authors.lastname: Gizatullina
authors.forename: Nikolay V
authors.initials: NV
authors.lastname: Kotov
mesh_terms: D002118:Calcium / Q000378:metabolism; D002455:Cell Division; D002468:Cell Physiological Phenomena; D002633:Chemotaxis; D042541:Intracellular Space / Q000378:metabolism; D008564:Membrane Potentials; D008954:Models, Biological; D010247:Paramecium / Q000166:cytology / Q000378:metabolism; D013269:Stochastic Processes; D049490:Systems Biology / Q000379:methods*
chemical_list: D002118:Calcium