Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives.
A series of new 2-substituted [4-(1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one derivatives 7a-h to 9a-h were designed and synthesized from methyl (4-oxo-3,4-dihydrophthalazin-1-yl)acetate (4), which in was turn prepared from phthalic anhydride. The structure of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. Several of these compounds showed antimicrobial activity.
Sridhara
Ajjanna M
AM
Advinus Therapeutics Pvt. Ltd., 21 & 22, Peenya II phase, Bangalore, 560 058 Karnataka, India.
Reddy
Kallam R Venugopala
KR
Keshavayya
Jathi
J
Goud
Palusa Sanath Kumar
PS
Somashekar
Bankavadi C
BC
Bose
Prosenjit
P
Peethambar
Sanenahalli K
SK
Gaddam
Satish Kumar
SK
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D000890:Anti-Infective Agents; D010793:Phthalazines