title: Ovarian steroid hormones: what's hot in the stem cell pool?
abstract: The vital role of ovarian hormones in the development of the normal breast foreshadowed their importance in mammary stem cell regulation. Two recent papers reveal that 17β-estradiol and progesterone control the size and repopulating ability of the mammary stem cell compartment. This likely occurs via paracrine signaling from steroid receptor-positive luminal cells to steroid receptor-negative stem cells. These findings illuminate roles for the female sex steroids in mobilizing the stem cell pool in the normal breast, and also provide a crucial link between the known hormonal risks of breast cancer and the potential stem cell origin of this disease.
authors.affiliation: Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Cittelly
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Richer
authors.forename: Carol A
authors.initials: CA
authors.lastname: Sartorius
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D048429:Cell Size; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D010052:Ovariectomy; D011374:Progesterone / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D011374:Progesterone; D004958:Estradiol
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9744-9
references.pmid: 12897242
references.citation: Nature. 2010 Jun 10;465(7299):803-7
references.pmid: 20445538
references.citation: Cancer Res. 1997 Nov 15;57(22):4987-91
references.pmid: 9371488
references.citation: Endocrinology. 2009 Jul;150(7):3318-26
references.pmid: 19342456
references.citation: Nature. 2010 Jun 10;465(7299):798-802
references.pmid: 20383121
references.citation: J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):3-15
references.pmid: 12160084
references.citation: Cancer Cell. 2007 Mar;11(3):259-73
references.pmid: 17349583
references.citation: Crit Rev Oncol Hematol. 2004 Jul;51(1):1-28
references.pmid: 15207251
references.citation: Cancer Res. 1999 Sep 1;59(17):4276-84
references.pmid: 10485472
references.citation: Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5774-9
references.pmid: 18391223
references.citation: J Natl Cancer Inst. 2006 Jul 19;98(14):1011-4
references.pmid: 16849684
references.citation: Nat Med. 2009 Aug;15(8):907-13
references.pmid: 19648928