Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
BACKGROUND
Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.


METHODS
To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.


RESULTS
The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults.


CONCLUSIONS
Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
Crawford
Stephen O
SO
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA.
Hoogeveen
Ron C
RC
Brancati
Frederick L
FL
Astor
Brad C
BC
Ballantyne
Christie M
CM
Schmidt
Maria Inês
MI
Young
Jeffery Hunter
JH
D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006019:Glycolysis; D006801:Humans; D007333:Insulin Resistance; D019344:Lactic Acid / Q000097:blood*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity; D010085:Oxidative Phosphorylation; D011859:Radiography; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D019344:Lactic Acid
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