miRNAkey: a software for microRNA deep sequencing analysis.
BACKGROUND
MicroRNAs (miRNAs) are short abundant non-coding RNAs critical for many cellular processes. Deep sequencing (next-generation sequencing) technologies are being readily used to receive a more accurate depiction of miRNA expression profiles in living cells. This type of analysis is a key step towards improving our understanding of the complexity and mode of miRNA regulation.


RESULTS
miRNAkey is a software package designed to be used as a base-station for the analysis of miRNA deep sequencing data. The package implements common steps taken in the analysis of such data, as well as adds unique features, such as data statistics and multiple read determination, generating a novel platform for the analysis of miRNA expression. A user-friendly graphical interface is applied to determine the analysis steps. The tabular and graphical output contains general and detailed reports on the sequence reads and provides an accurate picture of the differentially expressed miRNAs in paired samples.


METHODS
See http://ibis.tau.ac.il/miRNAkey


BACKGROUND
nshomron@post.tau.ac.il


BACKGROUND
Supplementary data are available at Bioinformatics online.
Ronen
Roy
R
Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Gan
Ido
I
Modai
Shira
S
Sukacheov
Alona
A
Dror
Gideon
G
Halperin
Eran
E
Shomron
Noam
N
D001483:Base Sequence; D019295:Computational Biology; D030561:Databases, Nucleic Acid; D020869:Gene Expression Profiling; D035683:MicroRNAs / Q000737:chemistry*; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software
D035683:MicroRNAs