title: Four new cembrane diterpenes isolated from an Okinawan soft coral Lobophytum crassum with inhibitory effects on nitric oxide production.
abstract: Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of alpha-methylene-gamma-lactone, exhibited the significant effect on NO production.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Mpanzu
authors.initials: M
authors.lastname: Wanzola
authors.forename: Takaaki
authors.initials: T
authors.lastname: Furuta
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Kohno
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukumitsu
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yasukochi
authors.forename: Kosuke
authors.initials: K
authors.lastname: Watari
authors.forename: Chiaki
authors.initials: C
authors.lastname: Tanaka
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D009569:Nitric Oxide