Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa.
It is not known whether the apolipoprotein E (ApoE) &#x03B5;4 allelic variant is associated with human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African population, where HIV clade C is predominant. ApoE genotyping was performed on 144 participants in a larger study of HIV-associated neurocognitive disorders (HAND). There was a lower frequency of the &#x03B5;2 and &#x03B5;3 alleles in the HIV-positive group, compared to a group of 300 community-based newborn infants. There were no differences in ApoE genotype across different categories of HAND. The &#x03B5;4 allelic variant was less common in individuals with HAD than in those without HAD. These findings suggest that the &#x03B5;4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa.
Joska
John A
JA
Department of Psychiatry and Mental Health, University of Cape Town, South Africa. John.Joska@uct.ac.za
Combrinck
Marc
M
Valcour
Victor G
VG
Hoare
Jacqueline
J
Leisegang
Felicity
F
Mahne
Anna Cecilia
AC
Myer
Landon
L
Stein
Dan J
DJ
D015526:AIDS Dementia Complex / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000483:Alleles; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013019:South Africa
D044966:Anti-Retroviral Agents; D053327:Apolipoprotein E4
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