Cytidine-Ag+-purine base complexes as studied by electrospray ionization mass spectrometry.
The complexes of cytidine (C) with Ag(+) and adenosine (A), guanosine (G), inosine (In) and caffeine (Caf) were studied by electrospray ionization mass spectrometry (ESI-MS). Both collision-induced dissociation (CID) "in- source" and CID MS/MS experiments were performed. The stability of [C + G + Ag](+) and [C + In + Ag](+) ions in the gas phase was found to be much higher than that of [C + A + Ag](+) and [C + Caf + Ag](+) ions. It is reasonable to conclude that guanosine and inosine form bidentate complex with silver cation, by N7 atom and O=C6 oxygen atom, whereas adenosine and caffeine form monodentate complexes, by N3 atom of adenine and N9 atom of caffeine.
Frańska
Magdalena
M
Poznań University of Technology, Institute of Chemistry, Piotrowo 3, 60-965 Poznań, Poland. Magdalena.Franska@put.poznan.pl
D003562:Cytidine / Q000737:chemistry*; D004355:Drug Stability; D011687:Purines / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D011687:Purines; D012834:Silver; D003562:Cytidine