All serotypes of dengue virus induce HLA-A2 major histocompatibility complex class I promoter activity in human liver cells.
In contrast to many viruses that escape the host's immune responses by suppressing the major histocompatibility complex (MHC) class I pathway, flaviviruses have been shown to up-regulate the cell surface expression of MHC class I complex. The mechanism by which dengue virus (DV) achieves this up-regulation remains unclear. Our investigation on the HLA-A2 gene in human liver cells demonstrated that all four serotypes of dengue virus, DV1 to DV4, resulted in variable degrees of promoter induction. This illustrates the importance of MHC class I transcription regulation in primary infections by different DV serotypes that may have even greater impact in secondary infections, associated with increased disease severity.
Othman
Shatrah
S
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Rahman
Noorsaadah A
NA
Yusof
Rohana
R
D002460:Cell Line; D003716:Dengue Virus / Q000276:immunology*; D005786:Gene Expression Regulation; D015789:HLA-A2 Antigen / Q000235:genetics / Q000276:immunology*; D022781:Hepatocytes / Q000276:immunology* / Q000821:virology; D006801:Humans; D008285:Major Histocompatibility Complex; D015854:Up-Regulation
D015789:HLA-A2 Antigen