Effect of anastomotic length on the development of intimal hyperplasia in the distal anastomosis of bypass graft.
Many hemodynamic factors have been shown to be associated with increased intimal hyperplasia at the distal anastomosis of arterial bypass graft. However, the relationship between the length of anastomosis and the development of such a complication has not been studied before. The aim of this study was to assess this relationship at the distal anastomosis with a Dacron graft. Iliofemoral bypass using 6 mm Dacron grafts was performed in 10 German shepherd dogs. In accordance with preoperative randomization to individual animal legs, distal anastomoses were reconstructed using four different groups (A, B, C, and D), depending on the length of the arteriotomy: 3.0, 3.5, 4.0, and 4.5 times the internal diameter of the artery, respectively. The vessels were harvested 6 months after the operation, and specimens were processed for histologic and transmission electron microscopic (TEM) studies. Quantitative analysis was performed to assess the extent of intimal hyperplasia at three zones (heel, toe, and midzone of the arterial bed) of the distal anastomosis. Sixteen arterial bypasses were included in this study. Both light and TEM studies revealed evidence of intimal hyperplasia in the four groups. Quantitative analysis showed a significant decrease in intimal hyperplasia with increasing the length of the anastomosis at the heel, toe, or midzone of the arterial bed. Mean (mum +/- SD) intimal hyperplasia of the three zones together was significantly higher in group A than group B (585 +/- 106 vs 423 +/- 8.6, p < .001) and in group B than group C (423 +/- 8.6 vs 202 +/- 15, p < .001). However, the difference between group C and group D (202 +/- 15 vs 162 +/- 8.6; p = .13) was statistically insignificant. The present study showed that the length of the anastomosis is one of the hemodynamic factors involved in the development of intimal hyperplasia. Anastomotic techniques that resulted in the least intimal hyperplasia were end to side, with length 4 or 4.5 times the internal diameter of the artery.
Elsharawy
Mohamed A
MA
Department of Surgery, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. elsharawya@yahoo.co.uk
Naim
Magda M
MM
El-Daharawy
Mohamed Hussein Ali
MH
Shekidef
Mohammed Hassan Ali
MH
Ahmed
Ibrahim Hussein
IH
D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery* / Q000648:ultrastructure; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006965:Hyperplasia; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000601:surgery* / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D023421:Models, Animal; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D011859:Radiography; D013997:Time Factors; D017539:Tunica Intima / Q000648:ultrastructure; D014654:Vascular Patency
D011093:Polyethylene Terephthalates