What can we learn about cardioprotection from the cardiac mitochondrial proteome?
This review will summarize proteomic methods that are useful in studying the role of mitochondria in cardioprotection. The strengths and weaknesses of some of the different approaches are discussed. We focus on the cardiac mitochondrial proteome with emphasis on changes associated with cell death and protection, and we summarize how proteomic data have contributed to addressing the role of mitochondria in cardioprotection.
Gucek
Marjan
M
NHLBI Proteomics Core, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
Murphy
Elizabeth
E
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D016923:Cell Death; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods
D002316:Cardiotonic Agents; D024101:Mitochondrial Proteins
J Proteome Res. 2008 Jul;7(7):3054-9
18543960
Nat Biotechnol. 2009 Jun;27(6):557-9
19483679
Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H144-52
19429812
Mol Biotechnol. 2008 Nov;40(3):306-15
18780189
Circ Res. 2006 Jul 7;99(1):93-101
16741159
Cardiovasc Res. 2008 Oct 1;80(1):20-9
18558627
Circ Res. 2010 Jun 11;106(11):1681-91
20413785
Physiol Genomics. 2009 Jul 9;38(2):125-37
19454556
Cardiovasc Res. 2010 Oct 1;88(1):83-92
20558438
J Proteome Res. 2009 Jun;8(6):2838-50
19290621
Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2402-8
16687609
Circ Res. 2008 Oct 24;103(9):983-91
18802025
Biochemistry. 2006 Feb 28;45(8):2524-36
16489745
Nat Methods. 2007 Oct;4(10):798-806
17901869
J Pharmacol Exp Ther. 2005 Dec;315(3):1314-9
16144979
Mol Cell Proteomics. 2006 Apr;5(4):608-19
16415296
Circ Res. 2010 Feb 19;106(3):504-13
20035080
Biochem J. 2001 Jun 1;356(Pt 2):395-402
11368766
Arch Biochem Biophys. 2008 Jun 1;474(1):22-31
18284913
J Neurochem. 2003 Dec;87(6):1427-35
14713298
Circulation. 2008 Mar 4;117(9):1172-82
18285568
J Proteome Res. 2009 Oct;8(10):4665-75
19694452
Mol Cell. 2005 Jul 22;19(2):197-207
16039589
Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H496-9
15764678
J Mol Cell Cardiol. 2009 Feb;46(2):268-77
19027023
Biochem J. 2004 Sep 15;382(Pt 3):923-32
15339253
Circ Res. 2006 Oct 13;99(8):878-83
16960097
Nat Med. 2004 Nov;10(11):1200-7
15489859
Am J Physiol Cell Physiol. 2007 Feb;292(2):C689-97
16928776
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2637-45
18408135
Circ Res. 2008 May 9;102(9):1082-90
18356542
Drug Metabol Drug Interact. 2006;21(3-4):245-58
16841516
Biochem J. 2006 Mar 15;394(Pt 3):627-34
16371007
J Biol Chem. 2004 Aug 27;279(35):36192-200
15192091
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):726-31
20080742
Science. 2008 Sep 12;321(5895):1493-5
18787169
Proteomics. 2008 Oct;8(19):4066-82
18763707
Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2863-7
11356646
Mol Cell Proteomics. 2011 Feb;10(2):M110.000117
20495213
FASEB J. 2006 Aug;20(10):1715-7
16809435
Sci STKE. 2002 Oct 15;2002(154):pl16
12381836
Circ Res. 2009 Mar 27;104(6):796-804
19229060
Annu Rev Pharmacol Toxicol. 2009;49:199-221
18834307
Mitochondrion. 2004 Mar;3(4):187-204
16120354
Circ Res. 2006 Sep 29;99(7):706-14
16946135
Proteomics. 2007 Dec;7(24):4579-88
18072194
Circ Res. 2007 Nov 26;101(11):1155-63
17916778
ACS Chem Biol. 2010 Jan 15;5(1):105-19
20047291
Antioxid Redox Signal. 2008 Mar;10(3):579-99
18052718
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6297-302
19325130
Science. 2009 Feb 6;323(5915):793-7
19131594
Physiol Rev. 2008 Apr;88(2):581-609
18391174
Electrophoresis. 2004 Aug;25(15):2520-5
15300771
Circ Res. 2002 Mar 8;90(4):390-7
11884367
Circ Res. 2010 Feb 5;106(2):285-96
20133913
Cell. 2003 Nov 26;115(5):629-40
14651853
Genes Dev. 2007 Apr 1;21(7):784-96
17374715
Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H75-91
19855063
J Clin Invest. 2010 May;120(5):1441-53
20364086
J Proteome Res. 2008 Sep;7(9):3789-802
18707151
Mol Cell. 2006 Aug;23(4):607-18
16916647
J Biol Chem. 2004 Apr 16;279(16):15805-13
14739304
Annu Rev Biomed Eng. 2009;11:49-79
19400705
Biochim Biophys Acta. 2009 Jul;1787(7):774-80
19362067
Proteomics. 2008 Apr;8(8):1564-75
18348319
Proteomics. 2006 May;6(10):3154-69
16586429
Circ Res. 2006 Feb 17;98(3):403-11
16397145
Biochim Biophys Acta. 2009 Jan;1789(1):45-57
18603028
Sci STKE. 2001 Jun 12;2001(86):pl1
11752655
Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E422-32
18984854
J Proteome Res. 2009 Jun;8(6):2679-95
19351177
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9
19528654
Circ Res. 2003 May 2;92(8):873-80
12663490
Circulation. 2009 Jul 21;120(3):245-54
19581491
Biochem J. 2010 Aug 15;430(1):49-59
20533907
Mol Cell Proteomics. 2009 Jun;8(6):1324-37
19208617
Cardiovasc Res. 2005 Aug 1;67(2):234-44
15919068
J Biol Chem. 2010 Jul 30;285(31):23532-6
20558729
Oncogene. 2007 Apr 19;26(18):2606-20
17072346
Circ Res. 2005 Jul 8;97(1):78-85
15961716
J Clin Invest. 2004 Jun;113(11):1535-49
15173880
Clin Exp Pharmacol Physiol. 2008 Jul;35(7):812-9
18346168
J Physiol. 2009 Feb 15;587(Pt 4):851-72
19103678