The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting.
Adler
Sarah
S
Centre for Documentation and Evaluation of Alternatives to Animal Experiments, Federal Institute for Risk Assessment , Berlin, Germany. Sarah.Adler@bfr.bund.de
Bicker
Gerd
G
Bigalke
Hans
H
Bishop
Christopher
C
Blümel
Jörg
J
Dressler
Dirk
D
Fitzgerald
Joan
J
Gessler
Frank
F
Heuschen
Heide
H
Kegel
Birgit
B
Luch
Andreas
A
Milne
Catherine
C
Pickett
Andrew
A
Ratsch
Heidemarie
H
Ruhdel
Irmela
I
Sesardic
Dorothea
D
Stephens
Martin
M
Stiens
Gerhard
G
Thornton
Peter D
PD
Thürmer
René
R
Vey
Martin
M
Spielmann
Horst
H
Grune
Barbara
B
Liebsch
Manfred
M
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000826:Animal Testing Alternatives / Q000331:legislation & jurisprudence / Q000379:methods*; D000818:Animals; D001905:Botulinum Toxins / Q000633:toxicity*; D003964:Diaphragm / Q000187:drug effects / Q000502:physiology; D005060:Europe; D007928:Lethal Dose 50; D051379:Mice; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D015203:Reproducibility of Results
D001905:Botulinum Toxins; D000109:Acetylcholine