Modeling nosocomial transmission of rotavirus in pediatric wards.
Nosocomial transmission of viral and bacterial infections is a major problem worldwide, affecting millions of patients (and causing hundreds of thousands of deaths) per year. Rotavirus infections affect most children worldwide at least once before age five. We present here deterministic and stochastic models for the transmission of rotavirus in a pediatric hospital ward and draw on published data to compare the efficacy of several possible control measures in reducing the number of infections during a 90-day outbreak, including cohorting, changes in healthcare worker-patient ratio, improving compliance with preventive hygiene measures, and vaccination. Although recently approved vaccines have potential to curtail most nosocomial rotavirus transmission in the future, even short-term improvement in preventive hygiene compliance following contact with symptomatic patients may significantly limit transmission as well, and remains an important control measure, especially where resources are limited.
Kribs-Zaleta
Christopher M
CM
CNRS, UMR5558, Laboratoire de Biométrie et Biologie Évolutive, Université Lyon 1, Université de Lyon, Villeurbanne, France. kribs@uta.edu
Jusot
Jean-François
JF
Vanhems
Philippe
P
Charles
Sandrine
S
D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D004196:Disease Outbreaks / Q000517:prevention & control; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D017757:Infectious Disease Transmission, Professional-to-Patient / Q000517:prevention & control; D008954:Models, Biological; D012401:Rotavirus / Q000254:growth & development*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology
N Engl J Med. 2006 Jan 5;354(1):23-33
16394299
Am J Epidemiol. 1992 Aug 1;136(3):328-43
1415152
J Theor Biol. 2007 Dec 7;249(3):487-99
17905310
Med J Aust. 1996 Apr 1;164(7):395-8
8609848
N Engl J Med. 2006 Jan 5;354(1):11-22
16394298
PLoS One. 2008;3(12):e4036
19112501
Clin Infect Dis. 2001 Nov 15;33(10):1739-46
11595995
Aust Paediatr J. 1989 Jun;25(3):156-60
2764838
Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18420-5
19841263
Pediatr Infect Dis J. 2006 Jan;25(1 Suppl):S12-21
16397425
Proc Biol Sci. 2007 Feb 22;274(1609):599-604
17476782
Ann Biol Clin (Paris). 2000 Sep-Oct;58(5):601-6
11022103
J Infect Dis. 2005 Dec 1;192(11):2004-11
16267774
Pediatr Infect Dis J. 2001 Feb;20(2):184-8
11224839
Nat Rev Microbiol. 2007 Jul;5(7):529-39
17571094
Crit Care Med. 2001 Feb;29(2):405-12
11246324
J Math Biol. 1990;28(4):365-82
2117040
Infect Control Hosp Epidemiol. 1997 Feb;18(2):84-92
9120248
Clin Perform Qual Health Care. 1998 Apr-Jun;6(2):70-2
10180124
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13343-8
16141326
Infect Control Hosp Epidemiol. 2003 Jul;24(7):520-5
12887241
Bull Math Biol. 2007 Oct;69(7):2227-48
17453305
Math Biosci Eng. 2004 Jun;1(1):1-13
20369956
Pediatr Infect Dis J. 2007 Mar;26(3):233-7
17484220
Emerg Infect Dis. 1998 Jul-Sep;4(3):416-20
9716961
J Pediatr. 1977 May;90(5):698-702
192867
MMWR Morb Mortal Wkly Rep. 2009 Oct 23;58(41):1146-9
19847149
Eur J Pediatr. 1996 Nov;155(11):954-8
8911896
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6908-13
10359812
Lancet. 2000 Oct 14;356(9238):1307-12
11073019
Pediatr Infect Dis J. 1988 Feb;7(2):103-9
2830585
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1938-43
10677558
J Pediatr. 2006 Oct;149(4):441-7
17011311
Theor Popul Biol. 2003 Dec;64(4):439-49
14630481
Pathol Biol (Paris). 2004 Apr;52(3):131-7
15063932
J Hosp Infect. 1999 Oct;43(2):131-47
10549313
Emerg Infect Dis. 2004 Oct;10(10):1827-34
15504271
Comput Biomed Res. 1997 Aug;30(4):307-22
9339324