title: On the potential of a new IVUS elasticity modulus imaging approach for detecting vulnerable atherosclerotic coronary plaques: in vitro vessel phantom study.
abstract: Peak cap stress amplitude is recognized as a good indicator of vulnerable plaque (VP) rupture. However, such stress evaluation strongly relies on a precise, but still lacking, knowledge of the mechanical properties exhibited by the plaque components. As a first response to this limitation, our group recently developed, in a previous theoretical study, an original approach, called iMOD (imaging modulography), which reconstructs elasticity maps (or modulograms) of atheroma plaques from the estimation of strain fields. In the present in vitro experimental study, conducted on polyvinyl alcohol cryogel arterial phantoms, we investigate the benefit of coupling the iMOD procedure with the acquisition of intravascular ultrasound (IVUS) measurements for detection of VP. Our results show that the combined iMOD-IVUS strategy: (1) successfully detected and quantified soft inclusion contours with high positive predictive and sensitivity values of 89.7 ± 3.9% and 81.5 ± 8.8%, respectively, (2) estimated reasonably cap thicknesses larger than ∼300 µm, but underestimated thinner caps, and (3) quantified satisfactorily Young's modulus of hard medium (mean value of 109.7 ± 23.7 kPa instead of 145.4 ± 31.8 kPa), but overestimated the stiffness of soft inclusions (mean Young`s moduli of 31.4 ± 9.7 kPa instead of 17.6 ± 3.4 kPa). All together, these results demonstrate a promising benefit of the new iMOD-IVUS clinical imaging method for in vivo VP detection.
authors.affiliation: Laboratory TIMC-DynaCell, UJF, CNRS UMR 5525, In3S, Grenoble, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Le Floc'h
authors.forename: Guy
authors.initials: G
authors.lastname: Cloutier
authors.forename: Gérard
authors.initials: G
authors.lastname: Finet
authors.forename: Philippe
authors.initials: P
authors.lastname: Tracqui
authors.forename: Roderic I
authors.initials: RI
authors.lastname: Pettigrew
authors.forename: Jacques
authors.initials: J
authors.lastname: Ohayon
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*; D055119:Elastic Modulus; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008954:Models, Biological; D009336:Necrosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D017711:Nonlinear Dynamics; D019047:Phantoms, Imaging; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D011142:Polyvinyl Alcohol; D015203:Reproducibility of Results; D012421:Rupture / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D018084:Ultrasonography, Interventional / Q000295:instrumentation*
chemical_list: D011142:Polyvinyl Alcohol
references.citation: Ultrasound Med Biol. 2007 Aug;33(8):1199-205
references.pmid: 17466446
references.citation: Circulation. 2002 Aug 13;106(7):804-8
references.pmid: 12176951
references.citation: IEEE Trans Image Process. 2007 May;16(5):1437-45
references.pmid: 17491471
references.citation: Cardiol Rev. 2001 Jan-Feb;9(1):31-5
references.pmid: 11174913
references.citation: Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
references.pmid: 10807742
references.citation: IEEE Trans Biomed Eng. 2001 Jan;48(1):116-20
references.pmid: 11235583
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2008 Feb;55(2):319-26
references.pmid: 18334339
references.citation: J Am Coll Cardiol. 2005 Sep 20;46(6):937-54
references.pmid: 16168274
references.citation: IEEE Trans Med Imaging. 1998 Jun;17(3):419-28
references.pmid: 9735905
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 1992;39(2):262-7
references.pmid: 18263145
references.citation: Ultrasound Med Biol. 2005 Jan;31(1):85-91
references.pmid: 15653234
references.citation: J Biomed Mater Res. 2002;63(6):854-61
references.pmid: 12418034
references.citation: Cardiovasc Res. 1999 Feb;41(2):369-75
references.pmid: 10341836
references.citation: Circulation. 2003 Jun 24;107(24):3018-21
references.pmid: 12810617
references.citation: IEEE Trans Med Imaging. 2009 Jul;28(7):1126-37
references.pmid: 19164080
references.citation: Physiol Rev. 2006 Apr;86(2):515-81
references.pmid: 16601268
references.citation: Ultrasound Med Biol. 2006 Feb;32(2):201-10
references.pmid: 16464666
references.citation: J Am Coll Cardiol. 2002 Feb 20;39(4):604-9
references.pmid: 11849858
references.citation: Circ Res. 1992 Oct;71(4):850-8
references.pmid: 1516158
references.citation: JACC Cardiovasc Imaging. 2008 Nov;1(6):752-61
references.pmid: 19356512
references.citation: Phys Med Biol. 2002 Jun 21;47(12):2147-64
references.pmid: 12118606
references.citation: IEEE Trans Med Imaging. 2006 May;25(5):590-601
references.pmid: 16689263
references.citation: Med Eng Phys. 2003 May;25(4):289-98
references.pmid: 12649013
references.citation: J Am Coll Cardiol. 1998 Sep;32(3):663-4
references.pmid: 9741508
references.citation: Eur Heart J. 2002 Mar;23(5):405-13
references.pmid: 11846498
references.citation: Circulation. 2003 Oct 7;108(14):1664-72
references.pmid: 14530185
references.citation: Ultrasound Med Biol. 2005 Dec;31(12):1631-45
references.pmid: 16344126
references.citation: Ultrasound Med Biol. 2004 Jun;30(6):761-71
references.pmid: 15219956
references.citation: Circulation. 2001 Jul 17;104(3):365-72
references.pmid: 11457759
references.citation: J Am Coll Cardiol. 2007 Sep 4;50(10):933-9
references.pmid: 17765119
references.citation: J Biomech. 1995 May;28(5):501-12
references.pmid: 7775487
references.citation: Phys Med Biol. 2008 Jan 7;53(1):147-63
references.pmid: 18182693
references.citation: J Interv Cardiol. 2006 Feb;19(1):11-5
references.pmid: 16483334
references.citation: Circulation. 2002 Oct 8;106(15):2026-34
references.pmid: 12370230
references.citation: Phys Med Biol. 2005 Apr 7;50(7):1611-28
references.pmid: 15798347
references.citation: IEEE Trans Inf Technol Biomed. 2008 May;12(3):277-89
references.pmid: 18693495
references.citation: Am J Physiol. 1997 Jan;272(1 Pt 2):H425-37
references.pmid: 9038965
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar;54(3):498-509
references.pmid: 17375819
references.citation: IEEE Trans Biomed Eng. 2010 Jun;57(6):1520-8
references.pmid: 20172784
references.citation: Cardiovasc Eng. 2006 Sep;6(3):93-102
references.pmid: 16967325
references.citation: J Mech Behav Biomed Mater. 2009 Oct;2(5):542-9
references.pmid: 19627861
references.citation: Cardiovasc Eng. 2008 Dec;8(4):191-202
references.pmid: 19048372
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14678-83
references.pmid: 17003118
references.citation: Coron Artery Dis. 2001 Dec;12(8):655-63
references.pmid: 11811331
references.citation: J Biomech Eng. 1998 Oct;120(5):602-7
references.pmid: 10412437
references.citation: J Biomed Mater Res B Appl Biomater. 2006 Nov;79(2):305-11
references.pmid: 16680682
references.citation: Circulation. 2002 Mar 5;105(9):1135-43
references.pmid: 11877368
references.citation: J Acoust Soc Am. 2004 Aug;116(2):1276-86
references.pmid: 15376693
references.citation: Circulation. 1993 Apr;87(4):1179-87
references.pmid: 8462145
references.citation: Coron Artery Dis. 2004 Feb;15(1):13-20
references.pmid: 15201616
references.citation: J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C13-8
references.pmid: 16631505
references.citation: Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H717-27
references.pmid: 18586893
references.citation: J Magn Reson Imaging. 2007 Sep;26(3):460-79
references.pmid: 17729343