title: Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease.
abstract: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation and it is thought that neutrophils play a major role in the disease pathogenesis. Genetic polymorphism of the vitamin-D-binding protein (VDBP) gene is considered one of the candidates for variation in susceptibility to COPD. To evaluate the potential influences of VDBP gene polymorphisms on COPD, a case-control study was conducted in the Han population of north-east China. The VDBP polymorphic site was genotyped in 100 COPD patients and 100 controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. A significantly higher proportion of VDBP-1F homozygosity was found in COPD patients, while the frequency of VDBP-2 homozygosity was significantly lower in COPD patients, which seemed to suggest that VDBP-2 homozygocity provided a protective effect. These data suggest that the VDBP gene may be involved in COPD susceptibility in Chinese Han population.
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: L-H
authors.initials: LH
authors.lastname: Shen
authors.forename: X-M
authors.initials: XM
authors.lastname: Zhang
authors.forename: D-J
authors.initials: DJ
authors.lastname: Su
authors.forename: S-P
authors.initials: SP
authors.lastname: Yao
authors.forename: B-Q
authors.initials: BQ
authors.lastname: Yu
authors.forename: H-W
authors.initials: HW
authors.lastname: Wang
authors.forename: F-Z
authors.initials: FZ
authors.lastname: Lu
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D012129:Respiratory Function Tests; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D014809:Vitamin D-Binding Protein