title: Paraneoplastic Acanthosis Nigricans: The importance of exhaustive and repeated malignancy screening.
abstract: Paraneoplastic acanthosis nigricans (P-AN) characteristically has a sudden onset, rapid progression, and extensive cutaneous involvement. The association between P-AN and internal malignancy is well established and the most common association is with adenocarcinoma of gastrointestinal origin. We present the case of an 81-year-old man with a 12-month history of anorexia, weight loss, and clinical evidence of extensive acanthosis nigricans. After exhaustive and repeated investigations a papillary thyroid carcinoma and a follicular adenoma were identified and he improved upon its resection. To our knowledge, P-AN in association with thyroid neoplasm has been reported on only one previous occasion.
authors.affiliation: Barts and The London NHS Trust, London, UK.
authors.forename: Narmita
authors.initials: N
authors.lastname: Talsania
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Harwood
authors.forename: D
authors.initials: D
authors.lastname: Piras
authors.forename: Rino
authors.initials: R
authors.lastname: Cerio
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D000236:Adenoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome