[Regulation of cell survival by RAF kinases].
The RAF proteins (A-RAF, B-RAF et C-RAF) are a family of kinases that play a key role in the regulation of various aspects of cell physiology, among which cell proliferation, differentiation and survival. We review the literature regarding their anti-apoptotic effects, and we summarize the current view regarding how alterations in these mechanisms contribute to human carcinogenesis. Finally, we discuss new therapeutic perspectives based on the manipulation of cell survival by the RAF kinase pathway. double dagger.
Galmiche
Antoine
A
Laboratoire de biochimie, Inserm ERI12, CHU Nord Amiens, 80054 Amiens Cedex 1, France. galmiche.antoine@ chu-amiens. fr
Ezzoukhry
Zakaria
Z
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival / Q000502:physiology*; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D009369:Neoplasms / Q000201:enzymology; D014158:Transcription, Genetic; D048490:raf Kinases / Q000235:genetics / Q000378:metabolism*
D048490:raf Kinases