title: Hemodynamics model of fluid-solid interaction in internal carotid artery aneurysms.
abstract: The objective of this study is to present a relatively simple method to reconstruct cerebral aneurysms as 3D numerical grids. The method accurately duplicates the geometry to provide computer simulations of the blood flow. Initial images were obtained by using CT angiography and 3D digital subtraction angiography in DICOM format. The image was processed by using MIMICS software, and the 3D fluid model (blood flow) and 3D solid model (wall) were generated. The subsequent output was exported to the ANSYS workbench software to generate the volumetric mesh for further hemodynamic study. The fluid model was defined and simulated in CFX software while the solid model was calculated in ANSYS software. The force data calculated firstly in the CFX software were transferred to the ANSYS software, and after receiving the force data, total mesh displacement data were calculated in the ANSYS software. Then, the mesh displacement data were transferred back to the CFX software. The data exchange was processed in workbench software. The results of simulation could be visualized in CFX-post. Two examples of grid reconstruction and blood flow simulation for patients with internal carotid artery aneurysms were presented. The wall shear stress, wall total pressure, and von Mises stress could be visualized. This method seems to be relatively simple and suitable for direct use by neurosurgeons or neuroradiologists, and maybe a practical tool for planning treatment and follow-up of patients after neurosurgical or endovascular interventions with 3D angiography.
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China. shjwkk@sina.com
authors.forename: Xu
authors.initials: X
authors.lastname: Bai-Nan
authors.forename: Wang
authors.initials: W
authors.lastname: Fu-Yu
authors.forename: Liu
authors.initials: L
authors.lastname: Lei
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiao-Jun
authors.forename: Ju
authors.initials: J
authors.lastname: Hai-Yue
mesh_terms: D000465:Algorithms; D017542:Aneurysm, Ruptured / Q000473:pathology / Q000503:physiopathology; D015901:Angiography, Digital Subtraction; D001696:Biomechanical Phenomena; D001794:Blood Pressure / Q000502:physiology; D002533:Cerebral Angiography; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002532:Intracranial Aneurysm / Q000473:pathology / Q000503:physiopathology*; D008959:Models, Neurological; D015233:Models, Statistical; D009038:Motion; D011312:Pressure; D012984:Software
references.citation: J Vasc Surg. 1998 Apr;27(4):632-9
references.pmid: 9576075
references.citation: J Vasc Surg. 2002 Sep;36(3):589-97
references.pmid: 12218986
references.citation: Stroke. 2005 Sep;36(9):1933-8
references.pmid: 16081858
references.citation: AJNR Am J Neuroradiol. 2004 Jan;25(1):63-8
references.pmid: 14729530
references.citation: Stroke. 1997 Feb;28(2):398-403; discussion 403-4
references.pmid: 9040697
references.citation: AJNR Am J Neuroradiol. 2003 Aug;24(7):1436-45
references.pmid: 12917142
references.citation: AJNR Am J Neuroradiol. 2003 Apr;24(4):559-66
references.pmid: 12695182
references.citation: Stroke. 2004 Nov;35(11):2500-5
references.pmid: 15514200
references.citation: AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2550-9
references.pmid: 16286400
references.citation: J Vasc Surg. 2006 Mar;43(3):570-6; discussion 576
references.pmid: 16520175
references.citation: Neurosurgery. 1999 Dec;45(6):1315-20; discussion 1320-2
references.pmid: 10598698
references.citation: Cell. 1994 Sep 23;78(6):931-6
references.pmid: 7923362
references.citation: Stroke. 2003 Jan;34(1):187-92
references.pmid: 12511772
references.citation: Surgery. 1997 Aug;122(2):273-9; discussion 279-80
references.pmid: 9288132
references.citation: AJNR Am J Neuroradiol. 2004 Sep;25(8):1356-65
references.pmid: 15466332
references.citation: J Vasc Surg. 2003 Apr;37(4):724-32
references.pmid: 12663969
references.citation: J Biomech. 1998 Feb;31(2):179-84
references.pmid: 9593213
references.citation: J Endovasc Ther. 2004 Aug;11(4):494-502
references.pmid: 15298501
references.citation: Eur J Vasc Endovasc Surg. 2004 Aug;28(2):168-76
references.pmid: 15234698
references.citation: Am J Hypertens. 1993 Jul;6(7 Pt 2):283S-293S
references.pmid: 8398013