title: The elemental sulfur-responsive protein (SipA) from the hyperthermophilic archaeon Pyrococcus furiosus is regulated by sulfide in an iron-dependent manner.
abstract: The gene (sipA) encoding the sulfur-induced protein A (PF2025) is highly upregulated during growth of Pyrococcus furiosus on elemental sulfur (S(0)). Expression of sipA is regulated by sulfide, the product of S(0) reduction, but in an iron-dependent manner. SipA is proposed to play a role in intracellular iron sulfide detoxification.
authors.affiliation: Department of Biochemistry and Molecular Biology, Life Sciences Bldg., University of Georgia, Athens, GA 30602-7229, USA.
authors.forename: Sonya M
authors.initials: SM
authors.lastname: Clarkson
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Newcomer
authors.forename: Everett G
authors.initials: EG
authors.lastname: Young
authors.forename: Michael W W
authors.initials: MW
authors.lastname: Adams
mesh_terms: D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation / Q000187:drug effects; D019848:Gene Expression Regulation, Archaeal / Q000187:drug effects / Q000502:physiology; D006358:Hot Temperature; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D020027:Pyrococcus furiosus / Q000235:genetics / Q000378:metabolism*; D013440:Sulfides / Q000378:metabolism / Q000494:pharmacology*; D013455:Sulfur / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D019843:Archaeal Proteins; D008565:Membrane Proteins; D013440:Sulfides; D013455:Sulfur; D007501:Iron; D010088:Oxidoreductases; C442124:SipA protein, Pyrococcus furiosus
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