Clinical genetics of hereditary colorectal cancer.
Colorectal cancer (CRC) is a common disease, and approximately 25% of patients have a familial component. High-penetrance singlegene germline mutations conferring a true hereditary susceptibility account for around 5% to 6% of all cases. Lynch syndrome is the most common hereditary form of colorectal cancer. Much of the hereditary component in the remaining familial cases of CRC is likely polygenic, and many of the genetic changes involved are as yet unidentified. This article addresses the most clinically important CRC genetic syndromes.
Power
Derek G
DG
Clinical Genetics, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Gloglowski
Emily
E
Lipkin
Steven M
SM
D015510:Clinical Medicine; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D010580:Peutz-Jeghers Syndrome / Q000175:diagnosis / Q000235:genetics / Q000601:surgery