title: Highly efficient iridium-catalyzed asymmetric hydrogenation of unprotected β-enamine esters.
abstract: A highly efficient and enantioselective hydrogenation of unprotected β-enamine esters catalyzed by Ir-(S,S)-f-Binaphane complex has been developed. This methodology provides straightforward access to free β-amino acids in high yields with excellent enantioselectivities up to 97% ee and high reactivities (TON > 5000).
authors.affiliation: Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
authors.forename: Guohua
authors.initials: G
authors.lastname: Hou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Miaofeng
authors.initials: M
authors.lastname: Ma
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000588:Amines; D004952:Esters; D007495:Iridium