title: Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning.
abstract: Sweet solutions are commonly used in animal research to deliver drugs to test for addictive capacity and efficacy. In this study we compared the effects of a range of sucrose and saccharin concentrations on the performance of an operant assay. Our findings demonstrate that across a range of sucrose solutions some produce a success ratio which could mistakenly be labeled allodynic demonstrating the importance of choosing the correct reward solution.
authors.affiliation: Center for Comprehensive Pain Research, University of Florida, Gainesville, FL, United States.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Nolan
authors.forename: Robert M
authors.initials: RM
authors.lastname: Caudle
authors.forename: John K
authors.initials: JK
authors.lastname: Neubert
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced*; D008297:Male; D009753:Nutritive Value; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D054772:Rats, Hairless; D017207:Rats, Sprague-Dawley; D012201:Reward; D012439:Saccharin / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013395:Sucrose / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology*; D013697:Thermosensing / Q000187:drug effects
chemical_list: D013549:Sweetening Agents; D013395:Sucrose; D012439:Saccharin
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