N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas.
Absence of N-acetylaspartate (NAA) is one important diagnostic criterion of MR spectroscopy (MRS) that may suggest that an intracranial mass lesion is a metastasis. We report two cases of histopathology-confirmed intracranial metastatic mucinous adenocarcinoma, which predominantly showed a large metabolite peak at 2.0 ppm, mimicking an NAA peak of normal brain tissue. This finding could be of help in the interpretation of MRS in cases of intracranial enhancing mass lesions, metastases or gliomas.
Liu
Xiang
X
Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, PO Box 648, Rochester, NY 14642, USA. xiang_liu@urmc.rochester.edu
Germin
Barbara I
BI
Zhong
Jianhui
J
Ekholm
Sven
S
D000230:Adenocarcinoma / Q000175:diagnosis*; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D001706:Biopsy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006023:Glycoproteins / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D009362:Neoplasm Metastasis
D006023:Glycoproteins; D001224:Aspartic Acid; C000179:N-acetylaspartate