title: [Vascular dementia].
abstract: Vascular dementia (VaD) constitutes the second most frequent cause of dementia following Alzheimer's disease (AD). In contrast to AD, VaD encompasses a variety of conditions and dementia mechanisms including multiple and strategic infarcts, widespread white matter lesions and hemorrhages. The diagnosis of VaD is based on the patient history, the clinical evaluation and neuroimaging. Treatment of VaD should account for the underlying vascular condition and is directed towards the control of vascular risk factors and stroke prevention. The need for early diagnosis and preventive treatment has promoted the concept of vascular cognitive impairment (VCI). Harmonization standards for the description and study of VCI have recently been published. A common and distinct subtype of VaD is subcortical ischemic vascular dementia (SIVD) which is related to cerebral small vessel disease. SIVD is clinically characterized by impairment of executive functions and processing speed with relatively preserved memory. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic variant of SIVD, represents an important differential diagnosis and may serve as a model of SIVD.
authors.affiliation: Neurologische Klinik und Poliklinik, Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland. Nils.Peters@med.uni-muenchen.de
authors.forename: N
authors.initials: N
authors.lastname: Peters
authors.forename: M
authors.initials: M
authors.lastname: Dichgans
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D046589:CADASIL / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D015161:Dementia, Multi-Infarct / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D033183:Interdisciplinary Communication; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008559:Memantine / Q000627:therapeutic use; D009483:Neuropsychological Tests; D010348:Patient Care Team; D011157:Population Dynamics; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy
chemical_list: D002800:Cholinesterase Inhibitors; D008559:Memantine
references.citation: Stroke. 2004 Jul;35(7):1603-8
references.pmid: 15155961
references.citation: Brain. 2004 Nov;127(Pt 11):2533-9
references.pmid: 15364702
references.citation: Lancet Neurol. 2003 Feb;2(2):89-98
references.pmid: 12849265
references.citation: Stroke. 2006 Sep;37(9):2220-41
references.pmid: 16917086
references.citation: Lancet Neurol. 2009 Nov;8(11):1006-18
references.pmid: 19782001
references.citation: Neurology. 1993 Feb;43(2):250-60
references.pmid: 8094895
references.citation: Lancet. 1998 Oct 24;352(9137):1347-51
references.pmid: 9802273
references.citation: Acta Psychiatr Scand. 2009 Apr;119(4):252-65
references.pmid: 19236314
references.citation: Am J Psychiatry. 2005 Nov;162(11):2078-85
references.pmid: 16263847
references.citation: Arch Intern Med. 2003 May 12;163(9):1069-75
references.pmid: 12742805
references.citation: Neurology. 1998 Aug;51(2):452-7
references.pmid: 9710018
references.citation: Lancet Neurol. 2007 Sep;6(9):782-92
references.pmid: 17689146
references.citation: Lancet Neurol. 2008 Apr;7(4):310-8
references.pmid: 18296124
references.citation: JAMA. 1997 Mar 12;277(10):813-7
references.pmid: 9052711
references.citation: J Am Geriatr Soc. 2008 Aug;56(8):1424-33
references.pmid: 18662209
references.citation: JAMA. 2005 Oct 19;294(15):1934-43
references.pmid: 16234500
references.citation: Neurology. 2001 Mar 13;56(5):628-34
references.pmid: 11245715
references.citation: Curr Atheroscler Rep. 2007 Oct;9(4):326-32
references.pmid: 18173961
references.citation: Br J Psychiatry. 2002 Mar;180:270-6
references.pmid: 11872521
references.citation: Neurology. 1998 Jul;51(1):159-62
references.pmid: 9674796
references.citation: Stroke. 2005 Dec;36(12):2559-65
references.pmid: 16269644
references.citation: Neuroepidemiology. 2003 May-Jun;22(3):161-4
references.pmid: 12739527
references.citation: Neuroepidemiology. 1995;14(5):240-57
references.pmid: 7477666
references.citation: Neurology. 2006 May 23;66(10):1517-22
references.pmid: 16717211
references.citation: Lancet Neurol. 2002 Nov;1(7):426-36
references.pmid: 12849365
references.citation: Neurobiol Aging. 2006 Dec;27(12):1769-85
references.pmid: 16300856
references.citation: Ann Neurol. 1998 Nov;44(5):731-9
references.pmid: 9818928