title: Higher adiponectin levels predict greater weight gain in healthy women in the Nurses' Health Study.
abstract: Adiponectin and resistin's possible roles in weight regulation have received little attention. We tested the hypothesis that adipokine levels predict future weight gain in women in the Nurses' Health Study. Among women who provided blood samples in 1990, we studied 1,063 women who did not develop diabetes ("healthy") and 984 women who subsequently developed diabetes. Total and high-molecular-weight (HMW) adiponectin and resistin levels were measured using enzyme-linked immunosorbent assay. Women who did not developed diabetes had a mean BMI of 26.3 ± 6.0 kg/m(2) at baseline and gained 2.0 ± 6.1 kg over 4 years. Women who developed diabetes had a mean BMI of 30.1 ± 5.4 kg/m(2) at baseline, and gained 2.4 ± 7.1 kg over 4 years. In women who did not developed diabetes, higher baseline levels of total and HMW adiponectin were associated with significantly greater weight gain after adjustment for age, BMI, physical activity, diet, and other covariates: women in the highest quintile of total adiponectin gained 3.18 kg compared to women in the lowest quintile who gained 0.80 kg (fully adjusted; P for trend <0.0001). Adiponectin was not significantly associated with weight gain in women who subsequently developed diabetes. Resistin levels were not associated with weight gain in either women who did or did not develop diabetes during the follow-up. We conclude that elevated adiponectin levels are associated with higher weight gain in healthy women, independent of confounding risk factors. High adiponectin production by adipocytes might be a sign of "healthy" adipose tissue with further capacity to store fat.
authors.affiliation: General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Hivert
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Peter
authors.initials: P
authors.lastname: Shrader
authors.forename: Christol S
authors.initials: CS
authors.lastname: Mantzoros
authors.forename: James B
authors.initials: JB
authors.lastname: Meigs
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D052243:Resistin / Q000097:blood / Q000502:physiology; D012307:Risk Factors; D015430:Weight Gain / Q000502:physiology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D052243:Resistin
references.citation: Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E402-10
references.pmid: 14625202
references.citation: J Clin Endocrinol Metab. 2006 Aug;91(8):2906-12
references.pmid: 16735483
references.citation: Nat Rev Cancer. 2005 May;5(5):388-96
references.pmid: 15864280
references.citation: J Clin Endocrinol Metab. 2003 Oct;88(10):4848-56
references.pmid: 14557464
references.citation: Am J Epidemiol. 1983 Jun;117(6):651-8
references.pmid: 6859020
references.citation: Clin Endocrinol (Oxf). 2009 Mar;70(3):408-14
references.pmid: 18624998
references.citation: Obesity (Silver Spring). 2007 Apr;15(4):967-76
references.pmid: 17426332
references.citation: Biochem Biophys Res Commun. 2005 Nov 18;337(2):540-50
references.pmid: 16202386
references.citation: Ann Intern Med. 2008 Sep 2;149(5):307-16
references.pmid: 18765700
references.citation: J Clin Endocrinol Metab. 2006 Jul;91(7):2776-81
references.pmid: 16608891
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1291-3
references.pmid: 17548700
references.citation: Diabetes. 2002 Oct;51(10):2964-7
references.pmid: 12351434
references.citation: JAMA. 1999 Oct 20;282(15):1433-9
references.pmid: 10535433
references.citation: J Clin Endocrinol Metab. 2008 Aug;93(8):3165-72
references.pmid: 18492747
references.citation: Arch Intern Med. 2001 Jul 9;161(13):1581-6
references.pmid: 11434789
references.citation: Diabetes. 2004 May;53(5):1279-84
references.pmid: 15111497
references.citation: Diabetes. 2004 Mar;53(3):693-700
references.pmid: 14988254
references.citation: Diabetes. 2001 May;50(5):1126-33
references.pmid: 11334417
references.citation: Am J Epidemiol. 2005 Dec 15;162(12):1189-97
references.pmid: 16236994