The role of serotonin in respiratory function and dysfunction.
Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.
Hilaire
Gérard
G
Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2 M), Unité Mixte de Recherche 6231, CNRS-Université Aix-Marseille II & III, Faculté Saint Jérôme, Marseille, France.
Voituron
Nicolas
N
Menuet
Clément
C
Ichiyama
Ronaldo M
RM
Subramanian
Hari H
HH
Dutschmann
Mathias
M
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002658:Developmental Disabilities / Q000150:complications / Q000378:metabolism; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012119:Respiration; D012120:Respiration Disorders / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012701:Serotonin / Q000737:chemistry / Q000378:metabolism*
D011985:Receptors, Serotonin; D012701:Serotonin
Sleep. 2008 Nov;31(11):1535-41
19014073
J Lab Clin Med. 1958 Jan;51(1):57-62
13514208
Acta Neuropathol. 2001 Jun;101(6):555-64
11515783
Synapse. 1987;1(6):582-8
3455563
Cardiovasc Drugs Ther. 1990 Jan;4 Suppl 1:27-32
2285647
J Neurochem. 1996 Sep;67(3):1072-7
8752114
Mol Neurobiol. 2007 Feb;35(1):45-54
17519505
J Comp Neurol. 2001 Apr 30;433(2):157-82
11283957
J Comp Neurol. 1993 Aug 15;334(3):466-76
8376628
Auton Neurosci. 2002 Feb 28;96(1):59-62
11911503
J Neurosci. 2006 Dec 6;26(49):12781-8
17151281
Dev Neurobiol. 2009 Sep 15;69(11):689-704
19449313
J Physiol. 1953 May 28;120(3):311-8
13070202
Acta Neuropathol. 2007 Jan;113(1):53-62
17031655
J Physiol. 1993 Jul;466:367-81
7692042
Curr Pharm Des. 2008;14(32):3466-73
19075722
J Physiol. 1954 Feb 26;123(2):277-88
13143510
J Clin Psychopharmacol. 2009 Apr;29(2):174-8
19512981
J Appl Physiol (1985). 2001 Apr;90(4):1247-57
11247921
Ann N Y Acad Sci. 1990;600:36-52
2252320
Respir Care. 2003 Oct;48(10):956-8
14525632
Novartis Found Symp. 2006;272:95-9; discussion 100-5, 131-40
16686431
Am J Psychiatry. 1995 Aug;152(8):1168-73
7625465
Respir Physiol Neurobiol. 2009 May 30;167(1):133-43
18707030
J Physiol. 1993 Feb;461:213-33
8350262
Prog Neurobiol. 2003 Jun;70(2):83-244
12927745
J Physiol. 2005 Jul 15;566(Pt 2):543-57
15878953
J Neurosci. 2010 Feb 3;30(5):1810-21
20130190
Exp Physiol. 2008 Jul;93(7):773-97
18469069
J Physiol. 2007 Mar 15;579(Pt 3):863-76
17204503
J Appl Physiol (1985). 2007 Nov;103(5):1780-8
17823301
Am J Med Genet A. 2006 Aug 1;140(15):1687-91
16830328
Pediatr Pulmonol. 2008 Nov;43(11):1045-1060
18831533
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):133-43
19481178
J Appl Physiol (1985). 2010 May;108(5):1425-32
20133432
J Neurosci. 1986 Apr;6(4):1185-93
3701414
Clin Pharmacol Ther. 2007 Jan;81(1):59-68
17186000
Neurosci Lett. 1997 Jul 11;230(1):29-32
9259456
Brain Res. 2003 Jun 6;974(1-2):82-7
12742626
Respir Physiol Neurobiol. 2010 Sep 30;173(2):146-56
20659592
J Appl Physiol (1985). 1996 Jan;80(1):108-15
8847290
J Soc Biol. 2004;198(1):18-21
15146951
J Neurochem. 1997 Apr;68(4):1495-502
9084419
Auton Neurosci. 2007 Mar 30;132(1-2):81-102
17236817
J Pharmacol Exp Ther. 1952 May;105(1):58-73
14939154
Science. 1948 Sep 24;108(2804):329-30
17748034
Clin Pharmacol Ther. 2005 Sep;78(3):278-87
16153398
Psychiatry Res. 2009 Sep 30;173(3):212-7
19682865
Ann N Y Acad Sci. 1990;600:93-103; discussion 103
2123618
Brain Res. 1987 Aug 4;417(1):12-20
3620972
Neuroscience. 1981;6(4):557-618
7017455
Neuron. 2003 Jan 23;37(2):233-47
12546819
Am J Physiol Regul Integr Comp Physiol. 2009 Jul;297(1):R34-41
19386986
Nat Neurosci. 2009 Aug;12(8):1028-35
19578380
Acta Histochem Suppl. 1981;24:107-22
6785822
Nat Rev Neurosci. 2003 Dec;4(12):1002-12
14618156
Pediatr Res. 2006 Oct;60(4):443-9
16940240
Acta Neuropathol. 2007 Sep;114(3):213-20
17639427
Aust J Exp Biol Med Sci. 1951 Nov;29(6):401-15
14904317
Respir Physiol Neurobiol. 2008 Dec 31;164(3):350-7
18775520
Brain Res. 1997 Jan 30;747(1):156-9
9042541
Sleep. 2007 Oct;30(10):1295-302
17969463
Neurobiol Aging. 2007 Mar;28(3):343-50
16513221
J Physiol. 1999 Jan 15;514 ( Pt 2):567-78
9852336
Am J Med Genet A. 2003 Mar 15;117A(3):268-74
12599191
Neurosci Lett. 1989 Oct 23;105(1-2):34-40
2485883
J Comp Neurol. 1998 Nov 30;401(4):506-24
9826275
Mt Sinai J Med. 2010 Jan-Feb;77(1):3-16
20101716
Neuropathol Appl Neurobiol. 2009 Aug;35(4):406-16
19508444
J Neurosci. 1999 Aug 15;19(16):7007-24
10436056
Sleep. 2007 Jan;30(1):35-41
17310863
Age (Dordr). 2010 Dec;32(4):483-95
20508993
Sleep Med. 2009 Dec;10(10):1101-6
19699148
Ann Neurol. 2004 Mar;55(3):418-22
14991820
J Physiol. 1960 May;151:342-51
14430544
Science. 1995 Jun 23;268(5218):1763-6
7792602
Eur J Appl Physiol. 2010 May;109(1):27-33
19949811
J Neurosci. 1999 Dec 1;19(23):10348-56
10575032
Laryngoscope. 2005 Jan;115(1):105-9
15630377
J Nucl Med. 2009 Aug;50(8):1260-6
19617327
J Physiol. 2005 Aug 1;566(Pt 3):807-19
15932887
Depress Anxiety. 2001;14(4):232-7
11754131
Respir Physiol Neurobiol. 2007 Oct 15;159(1):85-101
17656160
Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2611-23
19651661
J Physiol. 1992;451:605-29
1403827
Respir Physiol Neurobiol. 2008 Jul 31;162(2):117-25
18565803
Neurosci Lett. 1992 Aug 31;143(1-2):91-5
1436685
Brain Res. 1990 Dec 10;535(2):281-7
2073606
Neurosci Biobehav Rev. 2009 Feb;33(2):95-106
18573276
Arch Gen Psychiatry. 1993 Apr;50(4):306-17
8466392
Respir Physiol Neurobiol. 2008 Mar 20;161(1):10-5
18155647
Acta Physiol Scand Suppl. 1964;:SUPPL 232:1-55
14229500
Respir Physiol Neurobiol. 2004 Nov 15;143(2-3):155-65
15519552
J Neurosci. 2003 Mar 1;23(5):1569-73
12629158
Am J Physiol. 1953 Oct;175(1):157-61
13114371
C R Acad Sci III. 1992;314(10):451-4
1381658
J Neurosci. 2005 Dec 14;25(50):11521-30
16354910
Respir Physiol Neurobiol. 2009 Dec 31;169(3):234-42
19770073
Pediatr Pulmonol. 2002 Sep;34(3):209-17
12203850
Mov Disord. 2007 Jan 15;22(2):155-61
17133520
Prog Neurobiol. 1991;37(2):83-144
1947177
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):101-8
19394452
J Clin Endocrinol Metab. 2006 Dec;91(12):4911-5
17003096
J Comp Neurol. 1990 May 8;295(2):208-18
2358513
Physiol Rev. 1992 Jan;72(1):165-229
1731370
Annu Rev Neurosci. 2003;26:239-66
12598679
Brain Res Bull. 1982 Jul-Dec;9(1-6):xi-xv
7172023
J Physiol. 1996 Aug 15;495 ( Pt 1):255-65
8866368
Expert Opin Pharmacother. 2006 Jan;7(1):11-23
16370918
Biol Psychiatry. 1998 Dec 15;44(12):1321-8
9861475
Neurology. 2008 Jul 15;71(3):210-6
18625967
Br J Pharmacol Chemother. 1957 Sep;12(3):323-8
13460238
Arch Gen Psychiatry. 1988 Jan;45(1):31-9
2827599
J Comp Neurol. 2006 Nov 1;499(1):64-89
16958085
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):13-8
19712902
J Chem Neuroanat. 1997 Jun;13(1):1-21
9271192
J Neurosci. 1990 Apr;10(4):1091-8
2329370
Neurosci Lett. 1999 Feb 12;261(1-2):41-4
10081922
J Comp Neurol. 2010 Apr 1;518(7):1082-97
20127812
Science. 2008 Jul 4;321(5885):130-3
18599790
JAMA. 2006 Nov 1;296(17):2124-32
17077377
Neuron. 1996 Feb;16(2):297-307
8789945
J Physiol. 2000 Apr 1;524 Pt 1:279-92
10747198
Brain Res. 1979 May 18;168(1):43-56
455085
Neurology. 2009 Dec 8;73(23):2011-7
19955499
J Pharmacol Exp Ther. 1982 Sep;222(3):771-7
6286937
J Neurosci. 2005 Dec 7;25(49):11231-8
16339018
J Clin Invest. 1979 Aug;64(2):689-93
156738
J Comp Neurol. 1989 Mar 1;281(1):69-96
2466879
Auton Neurosci. 2006 Jun 30;126-127:320-31
16603418
Am J Psychiatry. 1993 Aug;150(8):1149-57
8392296
Acta Paediatr. 2009 Jan;98(1):58-61
18771483
Biol Neonate. 1978;34(1-2):55-60
29678
J Pharmacol Exp Ther. 1954 May;111(1):84-98
13163848
Genes Dev. 2003 Mar 15;17(6):729-37
12651891
Trends Endocrinol Metab. 2004 Jan-Feb;15(1):12-20
14693421
Anesth Analg. 2009 Apr;108(4):1169-76
19299781
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):109-18
19524074
Circ Res. 1953 Jul;1(4):354-62
13059881
J Comp Neurol. 2002 Sep 9;451(1):91-8
12209844
JAMA. 2010 Feb 3;303(5):430-7
20124538
Respir Physiol Neurobiol. 2005 Jul 28;147(2-3):159-76
15919245
Metabolism. 2003 Oct;52(10 Suppl 2):36-8
14577062
Neuroscience. 2009 Jan 23;158(2):751-65
19015006
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):119-24
19712904
Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2589-602
19651659
Neurosci Lett. 1996 Oct 4;216(3):151-4
8897480
Neuroscience. 1988 Jul;26(1):169-78
2458541
J Clin Sleep Med. 2009 Aug 15;5(4):305-9
19968005
J Neurosci. 2008 Mar 5;28(10):2495-505
18322094
Neurosci Lett. 1994 May 19;172(1-2):59-62
8084536
J Neurosci. 2008 Nov 19;28(47):12274-83
19020021
J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):8-18
20160205
Ann Neurol. 2001 Jan;49(1):53-66
11198297
Brain Lang. 1999 Sep;69(2):95-118
10447987
Am J Med Genet A. 2008 Apr 1;146A(7):930-3
18286597
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):59-68
19712903
Respir Physiol Neurobiol. 2009 Sep 30;168(3):230-8
19615472
Respir Physiol Neurobiol. 2010 Feb 28;170(2):173-82
20040383
J Physiol. 2004 Apr 1;556(Pt 1):235-53
14724193
Brain Dev. 2005 Sep;27(6):437-8
15967617
J Neurosci. 2000 Jun 15;20(12):4646-56
10844034
Science. 2003 Jul 11;301(5630):226-9
12855812
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):86-91
19560563
J Physiol. 2008 May 1;586(9):2321-9
18356199
Eur J Neurosci. 2008 Sep;28(6):1097-107
18783379
Trends Pharmacol Sci. 2008 Sep;29(9):472-81
19086344
J Neurol Sci. 2010 Jan 15;288(1-2):151-5
19818455
J Physiol. 1995 Sep 15;487 ( Pt 3):653-61
8544128
J Physiol. 1994 Apr 1;476(1):117-30
8046627
J Chem Neuroanat. 2003 Dec;26(4):331-43
14729135
Nat Rev Neurosci. 2004 Jun;5(6):449-61
15152195
Clin Cornerstone. 2004;6 Suppl 1A:S16-28
15259536
Stem Cell Rev. 2006;2(1):5-10
17142880
Am J Med Genet A. 2003 Oct 15;122A(3):238-45
12966525
J Cell Comp Physiol. 1954 Aug;44(1):141-63
13211759
Gene Expr Patterns. 2003 Oct;3(5):599-609
12971993
Pharmacol Rev. 1994 Jun;46(2):157-203
7938165
Neuropathol Appl Neurobiol. 2000 Dec;26(6):553-67
11123722
Am J Psychiatry. 2004 Jun;161(6):1096-102
15169699
J Neurosci. 2008 Feb 13;28(7):1745-55
18272695
Nat Neurosci. 2003 Sep;6(9):933-8
12897786
J Pediatr. 1997 Jan;130(1):89-94
9003856
J Pharmacol Exp Ther. 2000 Feb;292(2):704-13
10640309
J Psychosom Res. 2002 Jul;53(1):539-46
12127169
J Neurosci. 2007 Dec 19;27(51):14128-38
18094252
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):125-32
19712905
Behav Sleep Med. 2006;4(4):219-27
17083302
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):49-58
19394450
Pediatrics. 2001 Apr;107(4):690-2
11335745
Arch Ital Biol. 1979 Jan;117(1):1-12
45299
Neuroscience. 1989;31(1):105-13
2771052
Respir Physiol Neurobiol. 2008 Jan 1;160(1):21-7
17869191
Brain Res. 1997 Aug 8;765(1):122-8
9310402
J Comp Neurol. 2006 Apr 10;495(5):607-23
16498683
Neuron. 1996 Nov;17(5):823-35
8938116
Eur J Pharmacol. 1991 Jan 3;192(1):89-95
1828238