title: Psychoactive drugs as risk factors for functional decline among noninstitutionalized dependent elderly people.
abstract: OBJECTIVE
  To analyze the association between use of psychoactive drugs and functional decline among noninstitutionalized dependent elderly people.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  A total of 161 community-dwelling elderly people with functional dependence.
  
  
  METHODS
  The data were analyzed using logistic regression with adjustment for age models. The independent variables were the following: use of psychoactive drugs (antidepressants, anticonvulsants, anxiolytics, antipsychotics, or sedatives), cognitive decline (Mini-Mental State Examination score<20), and daytime sleepiness. The dependent variables were the following: dependence relating to activities of daily living (ADLs) and dependence relating to instrumental activities of daily living (IADLs).
  
  
  RESULTS
  Data on 131 individuals of mean age 77.5 years were analyzed. Psychoactive drugs were used by 33.6%. Age-adjusted univariate analysis showed associations between psychoactive drug use and both ADLs and IADLs. However, in multivariate analysis, only ADLs showed a significant association with psychoactive drug use, independent of cognitive decline and daytime sleepiness (OR=2.67; 95% CI: 1.04-6.85; P=.04).
  
  
  CONCLUSIONS
  There is a greater risk of impairment of ADLs among noninstitutionalized elderly people using psychoactive drugs. These results indicate the need for rational use of medication groups among this population with greater risk of functional impairment.
authors.affiliation: Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. marcoscabrera@uol.com.br
authors.forename: Marcos Aparecido Sarria
authors.initials: MA
authors.lastname: Cabrera
authors.forename: Mara Solange Gomes
authors.initials: MS
authors.lastname: Dellaroza
authors.forename: Celita Salmaso
authors.initials: CS
authors.lastname: Trelha
authors.forename: Lílian Bruniera Brunelli
authors.initials: LB
authors.lastname: Paccola
authors.forename: Sandra
authors.initials: S
authors.lastname: da Cruz Domiciano Perdigão
authors.forename: Meyre Eiras
authors.initials: ME
authors.lastname: de Barros Pinto
authors.forename: Thadeu Jairo Guerra
authors.initials: TJ
authors.lastname: Silva
authors.forename: Daniel Gonçalves
authors.initials: DG
authors.lastname: de Oliveira
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D001938:Brazil; D003072:Cognition Disorders / Q000139:chemically induced*; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment / Q000706:statistics & numerical data; D006305:Health Status Indicators; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D011619:Psychotropic Drugs