title: Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria.
abstract: Polycystic ovary syndrome (PCOS) is strongly associated with metabolic abnormalities in Western women. However, data from other populations and geographical regions are scarce. This study evaluated cardiovascular and metabolic risk factors in Chinese infertile women diagnosed with PCOS using the 2003 Rotterdam consensus criteria. A total of 615 women representing the four PCOS phenotypes (oligo- or anovulation (AO)+hyperandrogenism (HA)+polycystic ovaries (PCO), AO+HA, AO+PCO and HA+PCO) underwent standardized metabolic screening including a 75g oral glucose tolerance test. All groups presented with similar reproductive characteristics, with the only difference being a significantly higher Ferriman-Gallwey score for hirsutism (P=0.01) in the subgroup characterized by HA+PCO. Overall, the prevalence of metabolic syndrome was 6.4%, with no difference among the four groups (range of 2.3-12.2%). Metabolic syndrome was associated with body mass index (P<0.001), waist/hip ratio (P=0.002), index of insulin resistance (P=0.005) and fasting insulin (P=0.009) in multivariate analysis. Compared with Caucasians and Chinese women in Westernized societies, mainland Chinese women with PCOS have a low risk of metabolic syndrome and its presence does not vary across the specific PCOS phenotypes.
authors.affiliation: Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Guo
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Chen
authors.forename: N S
authors.initials: NS
authors.lastname: Macklon
authors.forename: Y H
authors.initials: YH
authors.lastname: Shi
authors.forename: H E
authors.initials: HE
authors.lastname: Westerveld
authors.forename: M J
authors.initials: MJ
authors.lastname: Eijkemans
authors.forename: B C J M
authors.initials: BC
authors.lastname: Fauser
authors.forename: A J
authors.initials: AJ
authors.lastname: Goverde
mesh_terms: D000328:Adult; D000858:Anovulation / Q000150:complications; D044466:Asian People; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006628:Hirsutism / Q000150:complications; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D050356:Lipid Metabolism; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism*
chemical_list: D005947:Glucose