The V-ATPase: small cargo, large effects.
About 30 years ago seminal reports of anion-sensitive proton-pumping activity associated with microsomal membranes initiated research on the plant vacuolar-type H(+)-ATPase (V-ATPase, VHA). Since, it has been firmly established that these complex molecular machines are essential for what can be defined as cellular logistics. In a eukaryotic cell, the flow of goods between compartments is achieved either by protein-mediated membrane transport or via vesicular trafficking. Over the past years, it has become increasingly clear that V-ATPases do not only energize secondary active transport but are also important regulators of membrane trafficking.
Schumacher
Karin
K
Heidelberg Institute for Plant Sciences (HIP), Universität Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany. karin.schumacher@hip.uni-heidelberg.de
Krebs
Melanie
M
D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D010944:Plants / Q000201:enzymology* / Q000378:metabolism*; D025262:Vacuolar Proton-Translocating ATPases / Q000235:genetics / Q000378:metabolism*
D025262:Vacuolar Proton-Translocating ATPases