title: [GABAergic neurons in the central nucleus of amygdala modulate sodium appetite in rats].
abstract: OBJECTIVE
  To determine whether the GABA-containing neurons in rat central nucleus of amygdala (CeA) can be activated by acute sodium deprivation.
  
  
  METHODS
  Acute sodium depletion was induced by subcutaneous injection of furosemide in rats followed by 24 h of dietary sodium deprivation. The rats underwent 0.3 mol/L NaCl/distilled water two bottle choice test, and the activated neurons were labeled and identified with GABA/Fos-double labeling immunohistochemistry.
  
  
  RESULTS
  The rats with acute sodium depletion exhibited significantly more numerous c-fos-positive neurons and GABA/Fos double-labeled neurons in the CeA than the control group (P<0.01, P<0.05). Consumption of 0.3 mol/L NaCl significantly increased the number of c-fos and GABA/Fos double labeled neurons compared to the distilled water group (P<0.001, P<0.01).
  
  
  CONCLUSIONS
  GABAergic neurons in the CeA may play an inhibitory role in the regulation of sodium intake in rats with acute sodium depletion.
authors.affiliation: Department of Physiology and Pathophysiology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Jian-qun
authors.initials: JQ
authors.lastname: Yan
authors.forename: Jin-rong
authors.initials: JR
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Shi-ru
authors.initials: SR
authors.lastname: Zhao
mesh_terms: D000679:Amygdala / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D059330:GABAergic Neurons / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000378:metabolism*; D012982:Sodium, Dietary
chemical_list: D017673:Sodium Chloride, Dietary; D012982:Sodium, Dietary