Glycosidic prodrugs of highly potent bifunctional duocarmycin derivatives for selective treatment of cancer.
Tietze
Lutz F
LF
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. ltietze@gwdg.de
von Hof
J Marian
JM
Müller
Michael
M
Krewer
Birgit
B
Schuberth
Ingrid
I
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D000080890:Duocarmycins; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000080890:Duocarmycins; D006027:Glycosides; D007211:Indoles; D011355:Prodrugs; D011760:Pyrrolidinones; C058289:duocarmycin A