The ING family tumor suppressors: from structure to function.
The Inhibitor of Growth (ING) proteins belong to a well-conserved family which presents in diverse organisms with several structural and functional domains for each protein. The ING family members are found in association with many cellular processes. Thus, the ING family proteins are involved in regulation of gene transcription, DNA repair, tumorigenesis, apoptosis, cellular senescence and cell cycle arrest. The ING proteins have multiple domains that are potentially capable of binding to many partners. It is conceivable, therefore, that such proteins could function similarly within protein complexes. In this case, within this family, each function could be attributed to a specific domain. However, the role of ING domains is not definitively clear. In this review, we summarize recent advances in structure-function relationships in ING proteins. For each domain, we describe the known biological functions and the approaches utilized to identify the functions associated with ING proteins.
Aguissa-Touré
Almass-Houd
AH
Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Wong
Ronald P C
RP
Li
Gang
G
D020816:Amino Acid Motifs; D042002:Chromatin Assembly and Disassembly; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005810:Multigene Family; D019913:Nuclear Localization Signals; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D018398:Homeodomain Proteins; D019913:Nuclear Localization Signals; D025521:Tumor Suppressor Proteins
J Biol Chem. 2005 Aug 5;280(31):28701-10
15964836
Biochem Biophys Res Commun. 2005 Jun 17;331(4):1032-8
15882981
J Biol Chem. 2004 Mar 5;279(10):9539-46
14665632
Carcinogenesis. 2008 Jul;29(7):1373-9
18375955
Cancer Res. 2007 Mar 15;67(6):2552-8
17363573
J Biol Chem. 2001 Jun 29;276(26):24068-74
11306585
Int J Cancer. 2008 Oct 1;123(7):1483-90
18636562
Nat Rev Mol Cell Biol. 2003 May;4(5):349-60
12728269
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9671-6
11481424
Biochim Biophys Acta. 2008 Oct;1783(10):1673-80
18513492
FEBS Lett. 2002 Feb 20;513(1):77-84
11911884
Structure. 2003 Jul;11(7):803-13
12842043
Cell Mol Life Sci. 2004 Sep;61(17):2173-80
15338048
J Clin Pathol. 2002 Aug;55(8):596-601
12147653
J Mol Biol. 2004 Apr 2;337(4):773-88
15033350
Mol Cell Biol. 2008 Nov;28(21):6632-45
18779315
Cancer Res. 2007 Mar 1;67(5):2054-61
17332334
Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5952-61
14676120
Mol Cell. 2006 Sep 1;23(5):685-95
16949365
Annu Rev Genet. 2009;43:559-99
19886812
Oncogene. 2003 Jan 23;22(3):343-50
12545155
Int J Cancer. 2010 Nov 1;127(9):2088-94
20131318
J Biol Chem. 2008 Jun 6;283(23):15956-64
18381289
J Biol Chem. 2008 May 9;283(19):13269-79
18334480
J Biol Chem. 2001 Mar 23;276(12):8734-9
11118440
Oncogene. 2006 Aug 24;25(37):5173-9
16607280
Biochim Biophys Acta. 2006 May-Jun;1761(5-6):560-9
16750654
Clin Cancer Res. 2007 Jul 15;13(14):4111-6
17634537
Cancer Res. 2001 Jul 1;61(13):4974-7
11431327
Leuk Res. 2002 Jul;26(7):631-5
12008079
J Steroid Biochem Mol Biol. 2003 Oct;87(1):57-63
14630091
Mol Cell Biol. 2000 Nov;20(21):8157-67
11027285
Cell. 2003 Jul 11;114(1):99-111
12859901
Trends Biochem Sci. 2007 Nov;32(11):509-19
17949986
Curr Drug Targets. 2009 May;10(5):455-64
19442117
Magn Reson Chem. 2009 Apr;47(4):352-8
19184981
Mol Cell. 2009 Nov 25;36(4):642-53
19941824
Proteins. 2008 Sep;72(4):1371-6
18623064
Cell Mol Life Sci. 2004 Oct;61(19-20):2597-613
15526165
Nature. 2006 Jul 6;442(7098):96-9
16728974
Nature. 2004 Mar 18;428(6980):328-32
15029197
J Mol Biol. 2000 Dec 15;304(5):723-9
11124022
Biochem Biophys Res Commun. 2008 Sep 26;374(3):490-5
18655775
Gene. 2003 Feb 27;305(2):141-50
12609734
Nat Genet. 1999 Nov;23(3):373
10545957
Proc Natl Acad Sci U S A. 2005 May 24;102(21):7481-6
15897452
J Cell Sci. 2001 Oct;114(Pt 19):3455-62
11682605
Curr Opin Genet Dev. 2004 Apr;14(2):196-202
15196467
FEBS Lett. 2006 Dec 22;580(30):6903-8
17157298
J Mol Biol. 2008 Jul 4;380(2):303-12
18533182
Nat Genet. 1996 Dec;14(4):415-20
8944021
EMBO J. 2004 Oct 13;23(20):4029-39
15457208
Cancer Res. 2001 Jun 1;61(11):4345-9
11389058
J Biol Chem. 2002 Aug 16;277(33):29832-9
12015309
Cytogenet Cell Genet. 1998;83(3-4):232-5
10072587
Exp Cell Res. 2005 Apr 1;304(2):531-43
15748897
Cell. 2001 Nov 30;107(5):559-62
11733055
Nature. 2006 Jul 6;442(7098):100-3
16728977
Nature. 1998 Jan 15;391(6664):295-8
9440695
Mol Cell Biol. 2006 Dec;26(24):9244-55
17030616
Nat Genet. 1997 Oct;17(2):146-8
9326931
Gen Comp Endocrinol. 2005 Oct;144(1):38-50
15955533
Oncogene. 1999 Sep 16;18(37):5187-93
10498868
Cytogenet Cell Genet. 1997;76(3-4):176-8
9186514
FEBS Lett. 2006 Jul 10;580(16):3787-93
16782091
Eur J Endocrinol. 2001 Apr;144(4):347-51
11275943
Mol Cell Biol. 2006 Apr;26(8):2947-54
16581770
Nat Cell Biol. 2008 Nov;10(11):1333-40
18836436
Exp Cell Res. 2007 May 1;313(8):1628-38
17379210
Am J Hematol. 2002 Feb;69(2):141-3
11835353
Cancer Res. 2006 Feb 15;66(4):1906-11
16488987
EMBO Rep. 2009 Oct;10(10):1168-74
19730436
Mol Cell Biol. 1997 Apr;17(4):2014-9
9121449
J Cell Biol. 2001 Dec 24;155(7):1265-73
11756476
Cancer Res. 2003 Sep 15;63(18):5785-92
14522900
J Biol Chem. 2001 Dec 14;276(50):47013-20
11600495
Sci STKE. 2006 Nov 07;2006(360):pe46
17090802
Mol Cell. 2002 May;9(5):945-56
12049732
Cancer Lett. 2000 Apr 28;152(1):15-22
10754201
Biochem Biophys Res Commun. 2002 Apr 26;293(1):163-6
12054579
Mol Cell Biol. 2005 Aug;25(15):6639-48
16024799
Oncogene. 2008 May 29;27(24):3384-92
18193082
Adv Enzyme Regul. 2005;45:171-85
16199078
Am J Hematol. 1999 Oct;62(2):118-9
10577281
Mol Cell. 2009 Jan 30;33(2):248-56
19187765
Cancer Res. 2000 Jun 15;60(12):3143-6
10866301
Somat Cell Mol Genet. 1997 May;23(3):233-6
9330636
Int J Oncol. 2003 Apr;22(4):927-31
12632089
Exp Cell Res. 2006 Jan 1;312(1):73-85
16288740
Biochim Biophys Acta. 2009 Jun-Aug;1789(6-8):451-9
19616654
Mol Cell. 1998 Jul;2(1):33-42
9702189
Nature. 2007 Aug 9;448(7154):718-22
17687328
EMBO J. 2001 Jan 15;20(1-2):165-77
11226167
Chem Biol. 2010 Jan 29;17(1):65-74
20142042
Mol Cell. 2006 Jan 6;21(1):51-64
16387653
J Exp Med. 2004 Jan 19;199(2):167-72
14734522
Mol Cell Biol. 2000 Jun;20(11):3807-16
10805724
Cell. 2010 Jan 22;140(2):183-95
20141833
J Cell Biochem. 2005 Dec 15;96(6):1127-36
16167330
Cancer Res. 1999 Dec 15;59(24):6197-204
10626813
Exp Cell Res. 2002 Oct 1;279(2):291-8
12243754
Cancer Lett. 1999 Dec 1;147(1-2):157-62
10660101
Exp Cell Res. 2001 Aug 1;268(1):1-6
11461112
J Biol Chem. 2005 Mar 25;280(12):11505-12
15649886
Cancer Res. 2003 May 15;63(10):2373-8
12750254
CRC Crit Rev Biochem. 1986;20(2):201-63
3519076
J Biol Chem. 2006 Nov 10;281(45):34677-86
16973615
Trends Biochem Sci. 2006 Jan;31(1):35-40
16297627
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2965-70
11867738
Oral Oncol. 2001 Apr;37(3):222-4
11287275
Gene. 2005 Aug 15;356:109-17
15935570
Trends Cell Biol. 2003 Jun;13(6):285-7; author reply 287-8
12791292
J Immunoassay Immunochem. 2004;25(1):71-80
15038618
Curr Pharm Des. 2009;15(31):3681-96
19925420
Mol Biol Evol. 2005 Jan;22(1):104-16
15356280
Trends Cell Biol. 2002 Nov;12(11):532-8
12446115
Cancer Res. 1997 Apr 1;57(7):1255-8
9102209
Oncogene. 2002 Jun 27;21(28):4462-70
12080476
Nucleic Acids Res. 2001 May 15;29(10):2052-8
11353074
Mol Cell Biol. 2002 Feb;22(3):835-48
11784859
Cell Mol Life Sci. 2010 Jun;67(12):1987-99
20195696
J Biol Chem. 2006 Sep 29;281(39):28831-6
16893883
Radiat Res. 2001 Nov;156(5 Pt 2):657-61
11604088
Mol Cell Biol. 2006 Nov;26(21):7871-9
16923967
Trends Biochem Sci. 1995 Feb;20(2):56-9
7701562
J Am Chem Soc. 2007 May 23;129(20):6498-506
17469822
FEBS J. 2009 Jul;276(14):3685-97
19490123
Cell Cycle. 2003 Mar-Apr;2(2):123-6
12695663
Int J Oncol. 2004 Jul;25(1):73-80
15201991
Oncogene. 2007 Aug 13;26(37):5433-8
17694084
Br J Cancer. 2006 Jul 3;95(1):80-6
16755297
Int J Biochem Cell Biol. 2005 May;37(5):1054-65
15743678
Mol Cell. 2009 Jan 30;33(2):257-65
19187766
Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16251-6
15528276
J Hum Genet. 2000;45(3):177-81
10807544
J Med Chem. 2008 May 8;51(9):2689-700
18386916