title: The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women.
abstract: The purpose of this study was to investigate whether the genetic polymorphisms of the uncoupling protein 1 (UCP1) and beta 3 adrenergic receptor (beta3-AR) were associated with differences in weight loss and lipid profiles in obese premenopausal women exposed to low-calorie meal replacements over a period of six weeks. Forty women between the ages of 20 and 35 were randomly divided into two groups, each of which consumed one of two low-calorie meal replacements containing either white rice or mixed rice. Although body weight, body mass index (BMI), blood glucose concentration, triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were not significantly different by the UCP1 genotype in the white rice group, there were significant differences in body weight (p = 0.041), BMI (p = 0.027), and blood glucose concentration (p = 0.047) between carriers and non-carriers of the G allele in the mixed rice group after the six-week meal replacement intervention. The beta3-AR polymorphism showed no apparent affect on these parameters. Dietary fiber affects weight gain since it is closely related with absorption of nutrients. As a result, the AA type UCP1 genotype produced significant weight loss in the mixed rice group, but not in the white rice group.
authors.affiliation: Department of Food & Nutrition, Bucheon University, Bucheon, South Korea.
authors.forename: Jung Yun
authors.initials: JY
authors.lastname: Kim
authors.forename: Sang Sun
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D001835:Body Weight; D004038:Diet, Reducing / Q000379:methods; D004043:Dietary Fiber; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000097:blood / Q000235:genetics*; D008055:Lipids / Q000097:blood* / Q000235:genetics; D024101:Mitochondrial Proteins / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000097:blood* / Q000235:genetics; D012275:Oryza; D011110:Polymorphism, Genetic / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000097:blood / Q000235:genetics*; D000071256:Uncoupling Protein 1; D015431:Weight Loss / Q000235:genetics*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007473:Ion Channels; D008055:Lipids; D024101:Mitochondrial Proteins; D022702:Receptors, Adrenergic, beta-3; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1