[Expression of glucose transporter-3 in the cerebral cortex of aging rats].
OBJECTIVE
To observe the changes in the expression of glucose transporter-3 (GLUT3) in the cerebral cortex of rats during aging and investigate the role of GLUT3 in the aging process of the nervous system.


METHODS
The cerebral tissues were collected from rats of 3, 18, 24, and 30 months old (10 in each age group), and the expression of GLUT3 in the cerebral cortex was detected by immunohistochemistry.


RESULTS
Under optical microscope, GLUT3-positive cells were found in every group. Within the age range of 3 to 8 months, GLUT3-positive cells increased significantly with age (P<0.01), but at 24-30 months of age, the number of GLUT3-positive cells reduced significant with age (P<0.01).


CONCLUSIONS
The expression changes of GLUT3 ir the cerebral cortex of rats during aging indicate that GLUT3 plays an important role in the maturation and aging of the nervous system.
Wu
Hai-qin
HQ
Department of Neurology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. whq60@sohu.com
Sha
Juan-juan
JJ
Ren
Bei
B
Wang
Hu-qing
HQ
Zhang
Gui-lian
GL
Li
Ming
M
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D051274:Glucose Transporter Type 3 / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D051274:Glucose Transporter Type 3; C495690:Slc2a3 protein, rat