title: Application of plant viruses as nano drug delivery systems.
abstract: Nano-sized drug delivery systems based on virus-derived platforms have promising delivery and targeting efficiencies. To date, much of our understanding of these systems is obtained from studies of animal viruses. Application of plant viruses for drug delivery is in the nascent stage, but it is becoming apparent that plant viral particles can be engineered to possess novel properties to meet the unique requirements of targeted drug delivery. Chemical functionalization of a plant viral particle surface can impart stealth properties to prolong in vivo circulation half-life and/or targeting capability to direct drug delivery to diseased tissues. The amino acid sequence of the viral coat protein can be genetically manipulated to yield protein cages of specific chemistry and morphology, while the conformation of the protein cage can be directed, via the external environment, to disassemble, then reassemble in vitro to exchange native viral genomic material with exogenous cargo. The purpose of this commentary is to evaluate current literature to assess the potential of nano-scale plant-virus-based drug delivery systems for the targeted delivery of chemotherapeutic agents.
authors.affiliation: Shanghai Institute of Materia Medica,, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Ren
authors.forename: Sek Man
authors.initials: SM
authors.lastname: Wong
authors.forename: Lee Yong
authors.initials: LY
authors.lastname: Lim
mesh_terms: D016503:Drug Delivery Systems; D036103:Nanotechnology; D010942:Plant Viruses
references.citation: Chem Biol. 2007 Oct;14(10):1152-62
references.pmid: 17961827
references.citation: J Control Release. 2007 Jul 16;120(1-2):41-50
references.pmid: 17512998
references.citation: J Gen Virol. 2006 Sep;87(Pt 9):2749-2754
references.pmid: 16894216
references.citation: Chem Commun (Camb). 2008 Jan 7;(1):88-90
references.pmid: 18401897
references.citation: PLoS Pathog. 2009 May;5(5):e1000417
references.pmid: 19412526
references.citation: Nano Lett. 2006 Apr;6(4):611-5
references.pmid: 16608253
references.citation: Nat Med. 2006 Mar;12(3):354-60
references.pmid: 16501571
references.citation: Angew Chem Int Ed Engl. 2002 Feb 1;41(3):459-62
references.pmid: 12491378
references.citation: Vaccine. 2001 Jun 14;19(27):3661-70
references.pmid: 11395200
references.citation: Biomacromolecules. 2003 May-Jun;4(3):472-6
references.pmid: 12741758
references.citation: Virology. 2005 Dec 20;343(2):224-35
references.pmid: 16185741
references.citation: Bioconjug Chem. 2007 May-Jun;18(3):836-43
references.pmid: 17407258