title: Co-expression of somatostatin receptor subtypes and estrogen receptor-α mRNAs by non-functioning pituitary adenomas in young patients.
abstract: The expression by non-functioning adenomas (NFoma) of somatostatin receptor (SSTR) subtypes and estrogen receptor (ERα) is poorly understood. Consequently, the mRNAs of SSTR subtypes (SSTR) 1, 2, 3, and 5, dopamine receptor (D2R), and ERα were measured by real-time quantitative RT-PCR in 59 NFomas and 50 functioning adenomas; the latter included 30 GH-secreting adenomas (GHomas) and 20 prolactinomas (PRLomas). NFomas expressed higher levels of SSTR3 than functioning adenomas but had lower levels of SSTR2, SSTR5 and D2R mRNAs than GHomas. Their ERα levels were higher than those of GHomas. The SSTR subtype mRNA levels in NFomas correlated significantly with each other; there was also a good correlation between the SSTR subtypes and ERα in NFomas. These correlations were largely only observed in younger patients (<50 years). The present study describes the differential expression of SSTR subtypes in the largest number of NFoma patients studied thus far, and further proposes possible involvements of SSTR3 and estrogen in the pathophysiology of NFomas.
authors.affiliation: Department of Neurosurgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan. nishioka@tokyo-med.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishioka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tamura
authors.forename: Haruka
authors.initials: H
authors.lastname: Iida
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kutsukake
authors.forename: Aiju
authors.initials: A
authors.lastname: Endo
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Jo
authors.initials: J
authors.lastname: Haraoka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000235:genetics*; D015175:Prolactinoma / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D017481:Receptors, Somatostatin