Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis.
OBJECTIVE
To determine which brain regions are relevant to deterioration in abstract reasoning as measured by Raven's Colored Progressive Matrices (CPM) in the context of dementia.


METHODS
MR images of 37 consecutive patients including 19 with Alzheimer's disease (AD) and 18 with amnestic mild cognitive impairment (aMCI) were retrospectively analyzed. All patients were administered the CPM. Regional grey matter (GM) volume was evaluated according to the regimens of voxel-based morphometry, during which a non-linear registration algorithm called Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra was employed. Multiple regression analyses were used to map the regions where GM volumes were correlated with CPM scores.


RESULTS
The strongest correlation with CPM scores was seen in the left middle frontal gyrus while a region with the largest volume was identified in the left superior temporal gyrus. Significant correlations were seen in 14 additional regions in the bilateral cerebral hemispheres and right cerebellum.


CONCLUSIONS
Deterioration of abstract reasoning ability in AD and aMCI measured by CPM is related to GM loss in multiple regions, which is in close agreement with the results of previous activation studies.
Yoshiura
Takashi
T
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. tyoshiu@radiol.med.kyushu-u.ac.jp
Hiwatashi
Akio
A
Yamashita
Koji
K
Ohyagi
Yasumasa
Y
Monji
Akira
A
Takayama
Yukihisa
Y
Kamano
Norihiro
N
Kawashima
Toshiro
T
Kira
Jun-Ichi
J
Honda
Hiroshi
H
D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis*; D003704:Dementia / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
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