Tailoring cyclic polyamines for inorganic/organic phosphate binding.
In this tutorial review, we will discuss the most significant achievements in the structure-based design of cyclic receptors containing mainly aliphatic amine groups as metal-free hosts for phosphate-based guests in aqueous environment; in particular, inorganic phosphates and mononucleotide anions. The bulk of our attention will be devoted to show how this class of receptors has structurally evolved following the attempts by chemists to optimize all factors indicated by Nature as necessary to achieve the best possible binding of phosphates via non-covalent interactions.
Bazzicalupi
Carla
C
Dipartimento di Chimica Ugo Schiff, Polo Scientifico, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy.
Bencini
Andrea
A
Lippolis
Vito
V
D018360:Crystallography, X-Ray; D029968:Escherichia coli Proteins / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000737:chemistry; D008968:Molecular Conformation; D010710:Phosphates / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D029968:Escherichia coli Proteins; D047028:Macrocyclic Compounds; D010710:Phosphates; D011073:Polyamines; D014867:Water