Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia.
A multidrug-resistant Escherichia coli isolate recovered in Australia produced a carbapenem-hydrolyzing β-lactamase. Molecular investigations revealed the first identification of the bla(NDM-1) metallo-β-lactamase gene in that country. In addition, this E. coli isolate expressed the extended-spectrum β-lactamase CTX-M-15, together with two 16S rRNA methylases, namely, ArmA and RmtB, conferring a high level of resistance to aminoglycosides.
Poirel
Laurent
L
Service de Bactériologie-Virologie, INSERM U914, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, 78 rue du Général Leclerc, Le Kremlin-Bicêtre cedex, France.
Lagrutta
Emilie
E
Taylor
Peter
P
Pham
Jeanette
J
Nordmann
Patrice
P
D000900:Anti-Bacterial Agents; D001315:Australia; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D047090:beta-Lactams; C506767:ArmA protein, E coli; D008780:Methyltransferases; C540682:RmtB protein, E coli; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
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