title: A new tool for detection of type I interferon activation in systemic lupus erythematosus.
abstract: The IFN-I pathway is activated in systemic lupus erythematosus (SLE) and appears to be important in the pathogenesis of the disease. As a result, several clinical trials of anti-IFN monoclonal antibodies, which hold promise to control the disease, have been launched. Additionally, activation of IFN-I might be important in the prognosis and activity assessment of the disease. Therefore, new biomarkers that reflect activity of the IFN-I pathway and are simple to measure, such as the monocyte CD64 receptor, are expected to have a great impact on the management of SLE, if properly validated.
authors.forename: Kyriakos A
authors.initials: KA
authors.lastname: Kirou
authors.forename: George D
authors.initials: GD
authors.lastname: Kalliolias
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D007370:Interferon Type I
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