title: Uterine lesions in 32 female miniature pet pigs.
abstract: Thirty-two 4-month-old to 19-year-old female miniature pet pigs were spayed. Uterine lesions were present in all except 8 pigs. The 24 remaining pigs had diffuse cystic endometrial hyperplasia, of which 14 had smooth muscle tumors, including leiomyomas and leiomyosarcomas, in the uterus or broad ligament. Nodular endometrial lesions-including adenocarcinomas, adenomas, and/or adenomyosis-were present in 10 pigs, 3 of which had concurrent smooth muscle tumors. Pyometra was present in 3 pigs. In uterine sections with cystic endometrial hyperplasia, adenomyosis, or adenomas, approximately 70% of epithelial nuclei expressed estrogen receptor and progesterone receptor immunohistochemically; in adenocarcinomas, expression was 20%. Regardless of malignancy, more than 50% of nuclei in smooth muscle tumors expressed estrogen receptor and progesterone receptor. Aging was associated with the development of uterine lesions in miniature pet pigs.
authors.affiliation: Veterinary Diagnostic and Investigational Laboratory, PO Box 1389, 43 Brighton Road, Tifton, GA 31793, USA. milha@uga.com
authors.forename: M R S
authors.initials: MR
authors.lastname: Ilha
authors.forename: S J
authors.initials: SJ
authors.lastname: Newman
authors.forename: S
authors.initials: S
authors.lastname: van Amstel
authors.forename: K A
authors.initials: KA
authors.lastname: Fecteau
authors.forename: B W
authors.initials: BW
authors.lastname: Rohrbach
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary; D000236:Adenoma / Q000473:pathology / Q000662:veterinary; D000818:Animals; D001956:Broad Ligament / Q000473:pathology; D004714:Endometrial Hyperplasia / Q000473:pathology / Q000662:veterinary; D004717:Endometrium / Q000473:pathology; D004967:Estrogens / Q000097:blood; D005260:Female; D007889:Leiomyoma / Q000473:pathology / Q000662:veterinary; D007890:Leiomyosarcoma / Q000473:pathology / Q000662:veterinary; D011374:Progesterone / Q000097:blood; D055112:Pyometra / Q000473:pathology / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000473:pathology*; D013556:Swine, Miniature / Q000033:anatomy & histology*; D014591:Uterine Diseases / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D014594:Uterine Neoplasms / Q000473:pathology / Q000662:veterinary; D014599:Uterus / Q000473:pathology
chemical_list: D004967:Estrogens; D011374:Progesterone