title: Synthesis of the natural enantiomer of neplanocin B.
abstract: (-)-Neplanocin B, the natural isomer of a component of the neplanocin family was diasteroselectively synthesized from 2,3-O-isopropylidene-D-1,4-ribonolactone. However, when evaluated against several DNA and RNA viruses in cell culture experiments, it did not show any antiviral activity.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR CNRS-UM, Université Montpellier, France.
authors.forename: Nadège
authors.initials: N
authors.lastname: Hamon
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Uttaro
authors.forename: Christophe
authors.initials: C
authors.lastname: Mathé
authors.forename: Christian
authors.initials: C
authors.lastname: Périgaud
mesh_terms: D000192:Actinomycetales / Q000737:chemistry; D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013237:Stereoisomerism; D014777:Virus Diseases / Q000188:drug therapy; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C031097:neplanocin B; D000241:Adenosine