Termination at sTop2.
In this issue of Molecular Cell, Fachinetti et al. provide the first comprehensive map of replication termination sites (TERs) in Saccharomyces cerevisiae (Fachinetti et al., 2010). Strikingly, the majority of TERs are occupied by topoisomerase 2, which shields these regions against genomic instability.
Alver
Robert C
RC
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Bielinsky
Anja-Katrin
AK
Cell. 1988 Nov 18;55(4):637-43
3052854
Cell. 2006 Jun 30;125(7):1309-19
16814717
Annu Rev Genet. 2008;42:211-33
18605898
Science. 1996 May 17;272(5264):1030-3
8638128
Mol Microbiol. 2008 Dec;70(6):1323-33
19019156
Mol Cell. 2009 Jun 26;34(6):722-34
19560424
Mol Cell. 2010 Aug 27;39(4):595-605
20797631
Microbiol Mol Biol Rev. 2005 Sep;69(3):501-26
16148308
Science. 2001 Dec 14;294(5550):2357-60
11743203
Mol Cell. 2003 Dec;12(6):1525-36
14690605