title: Thermodynamic aspects of solubility process of some sulfonamides.
abstract: The thermodynamic aspects of solubility process of sulfonamides with the general structures C(6)H(5)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-Cl) and 4-NH(2)-C(6)H(4)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-CN; 4-Cl; 4-OMe; 4-C(2)H(5)) in water, phosphate buffer with pH 7.4 and n-octanol (as phases modeling various drug delivery pathways) were studied using the isothermal saturated method.
authors.affiliation: Department of Computer-Aided Molecular Design, Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia. glp@isc-ras.ru
authors.forename: German L
authors.initials: GL
authors.lastname: Perlovich
authors.forename: Alex M
authors.initials: AM
authors.lastname: Ryzhakov
authors.forename: Nadezda N
authors.initials: NN
authors.lastname: Strakhova
authors.forename: Vladimir P
authors.initials: VP
authors.lastname: Kazachenko
authors.forename: Klaus-Jürgen
authors.initials: KJ
authors.lastname: Schaper
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Raevsky
mesh_terms: D020003:1-Octanol / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000032:analysis* / Q000737:chemistry; D002021:Buffers; D002623:Chemistry Techniques, Analytical; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013449:Sulfonamides / Q000032:analysis* / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D002021:Buffers; D012997:Solvents; D013449:Sulfonamides; D014867:Water; D020003:1-Octanol