Three new stereoisomers of condensed tannins from the roots of Rosa multiflora.
Three new stereoisomers of condensed tannins (1-3), and four known phenolic compounds (4-7) were isolated from the 80% acetone extract of the roots of Rosa multiflora Thunberg. The structures of these compounds were elucidated using 1D/2D NMR, high resolution (HR)-MS, and circular dichroism (CD) spectra. In order to evaluate their anti-oxidative and anti-inflammatory activities, their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and inhibitory activity on nitric oxide (NO) production were determined.
Park
Kwan Hee
KH
Department of Pharmacognosy, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
Kim
Sung Kyu
SK
Choi
Sun Eun
SE
Kwon
Joo Hee
JH
Oh
Myung Hwan
MH
Lee
Min Won
MW
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005609:Free Radicals / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009569:Nitric Oxide / Q000276:immunology; D010851:Picrates / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D044945:Proanthocyanidins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D027826:Rosa / Q000737:chemistry*; D013237:Stereoisomerism
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D044945:Proanthocyanidins; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl