LC for analysis of two sustained-release mixtures containing cough cold suppressant drugs.
A liquid chromatographic method was applied for the analysis of two sustained-release mixtures containing dextromethorphane hydrobromide, carbinoxamine maleate with either phenylephrine hydrochloride in pharmaceutical capsules (Mix 1) or phenyl-propanolamine, methylparaben, and propylparaben, which bonds as a drug base to ion exchange resin in pharmaceutical syrup (Mix 2). The method was used for their simultaneous determination using a CN column with a mobile phase consisting of acetonitrile-12 mM ammonium acetate in the ratio of 60:40 (v/v, pH 6.0) for Mix 1 and 45:55 (v/v, pH 6.0) for Mix 2.
El-Gindy
Alaa
A
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Sallam
Shehab
S
Abdel-Salam
Randa A
RA
D000996:Antitussive Agents / Q000032:analysis* / Q000737:chemistry; D002214:Capsules / Q000737:chemistry; D002852:Chromatography, Ion Exchange / Q000379:methods*; D003692:Delayed-Action Preparations; D003915:Dextromethorphan / Q000032:analysis* / Q000737:chemistry; D004355:Drug Stability; D016018:Least-Squares Analysis; D014663:Nasal Decongestants / Q000032:analysis* / Q000737:chemistry; D010226:Parabens / Q000032:analysis / Q000737:chemistry; D010656:Phenylephrine / Q000032:analysis* / Q000737:chemistry; D010665:Phenylpropanolamine / Q000032:analysis / Q000737:chemistry; D011725:Pyridines / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000996:Antitussive Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D014663:Nasal Decongestants; D010226:Parabens; D011725:Pyridines; D010656:Phenylephrine; D010665:Phenylpropanolamine; D003915:Dextromethorphan; C004649:carbinoxamine; C015358:methylparaben; C006068:propylparaben