title: The ING family tumor suppressors: from structure to function.
abstract: The Inhibitor of Growth (ING) proteins belong to a well-conserved family which presents in diverse organisms with several structural and functional domains for each protein. The ING family members are found in association with many cellular processes. Thus, the ING family proteins are involved in regulation of gene transcription, DNA repair, tumorigenesis, apoptosis, cellular senescence and cell cycle arrest. The ING proteins have multiple domains that are potentially capable of binding to many partners. It is conceivable, therefore, that such proteins could function similarly within protein complexes. In this case, within this family, each function could be attributed to a specific domain. However, the role of ING domains is not definitively clear. In this review, we summarize recent advances in structure-function relationships in ING proteins. For each domain, we describe the known biological functions and the approaches utilized to identify the functions associated with ING proteins.
authors.affiliation: Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
authors.forename: Almass-Houd
authors.initials: AH
authors.lastname: Aguissa-Touré
authors.forename: Ronald P C
authors.initials: RP
authors.lastname: Wong
authors.forename: Gang
authors.initials: G
authors.lastname: Li
mesh_terms: D020816:Amino Acid Motifs; D042002:Chromatin Assembly and Disassembly; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005810:Multigene Family; D019913:Nuclear Localization Signals; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
chemical_list: D018398:Homeodomain Proteins; D019913:Nuclear Localization Signals; D025521:Tumor Suppressor Proteins
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