[Cardiotoxic effects of breast cancer chemotherapy and their possible correction].
Clinical data are reported upon the examination of a group of 160 women aged 18-55, suffering of a breast cancer and subjected to polychemotherapy using various cytostatic schemes: (I) standard CAF scheme, course repetition each 4 weeks; (II) alternating CAF and AVCFM schemes (intermittent introductions), a total of 4 courses. For the reduction of the cardiotoxic effects of anthracyclines, one part of patients was given an antioxidant preparation of amber acid--Reamberin--whose administration substantially decreased both the frequency of cardial complaints and the expression of clinical manifestations of the astheno-neurotic syndrome and prevented the occurrence of systolic and diastolic dysfunction of myocardium and the heart rhythm and conductivity disturbances.
Reznikova
E A
EA
Kosenok
V K
VK
Nechaeva
G I
GI
Merkulov
V N
VN
Reznikov
A S
AS
D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006331:Heart Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008536:Meglumine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D013386:Succinates / Q000627:therapeutic use*; D055815:Young Adult
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D016166:Free Radical Scavengers; C549374:Reamberin; D013386:Succinates; D008536:Meglumine