title: The neurodevelopment of empathy in humans.
abstract: Empathy, which implies a shared interpersonal experience, is implicated in many aspects of social cognition, notably prosocial behavior, morality and the regulation of aggression. The purpose of this paper is to critically examine the current knowledge in developmental and affective neuroscience with an emphasis on the perception of pain in others. It will be argued that human empathy involves several components: affective arousal, emotion understanding and emotion regulation, each with different developmental trajectories. These components are implemented by a complex network of distributed, often recursively connected, interacting neural regions including the superior temporal sulcus, insula, medial and orbitofrontal cortices, amygdala and anterior cingulate cortex, as well as autonomic and neuroendocrine processes implicated in social behaviors and emotional states. Decomposing the construct of empathy into subcomponents that operate in conjunction in the healthy brain and examining their developmental trajectory provides added value to our current approaches to understanding human development. It can also benefit our understanding of both typical and atypical development.
authors.affiliation: Center for Cognitive and Social Neuroscience, Department of Psychology, University of Chicago, Chicago, IL 60637, USA. decety@uchicago.edu
authors.forename: Jean
authors.initials: J
authors.lastname: Decety
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development*; D004645:Empathy / Q000502:physiology*; D006801:Humans; D013312:Stress, Physiological
references.citation: Br J Psychol. 2009 Aug;100(Pt 3):455-71
references.pmid: 19063815
references.citation: J Neurosci. 2005 May 4;25(18):4641-8
references.pmid: 15872112
references.citation: Dev Psychol. 1998 Sep;34(5):1026-37
references.pmid: 9779748
references.citation: Soc Neurosci. 2008;3(3-4):334-47
references.pmid: 18979389
references.citation: Neuroimage. 2008 Feb 15;39(4):2076-85
references.pmid: 18082427
references.citation: J Am Acad Child Adolesc Psychiatry. 2002 Oct;41(10):1231-8
references.pmid: 12364845
references.citation: Brain. 2006 Sep;129(Pt 9):2508-16
references.pmid: 16844714
references.citation: Trends Cogn Sci. 2005 Mar;9(3):104-10
references.pmid: 15737818
references.citation: Soc Neurosci. 2007;2(1):28-47
references.pmid: 18633805
references.citation: Dev Psychopathol. 2008 Fall;20(4):1053-80
references.pmid: 18838031
references.citation: Dev Psychol. 2009 Mar;45(2):534-43
references.pmid: 19271837
references.citation: J Cogn Neurosci. 2002 Nov 15;14(8):1215-29
references.pmid: 12495527
references.citation: Mol Psychiatry. 2008 Sep;13(9):829, 833-57
references.pmid: 18574483
references.citation: J Child Psychol Psychiatry. 1981 Jul;22(3):247-61
references.pmid: 7263789
references.citation: Annu Rev Psychol. 2007;58:373-403
references.pmid: 17002554
references.citation: Brain Inj. 2007 Jun;21(6):623-9
references.pmid: 17577713
references.citation: Neuron. 2002 Jan 17;33(2):301-11
references.pmid: 11804576
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11382-7
references.pmid: 19549849
references.citation: J Cogn Neurosci. 2007 Jan;19(1):42-58
references.pmid: 17214562
references.citation: Trends Cogn Sci. 2004 Jun;8(6):239-41
references.pmid: 15165543
references.citation: Dev Psychol. 2004 Nov;40(6):1105-22
references.pmid: 15535760
references.citation: Neuroimage. 2009 Aug 15;47(2):722-34
references.pmid: 19439183
references.citation: Acta Psychol (Amst). 2004 Feb-Mar;115(2-3):167-83
references.pmid: 14962399
references.citation: Curr Opin Neurobiol. 2003 Aug;13(4):500-5
references.pmid: 12965300
references.citation: BMC Neurosci. 2008 Oct 21;9:102
references.pmid: 18939997
references.citation: Dev Psychopathol. 2002 Summer;14(3):477-98
references.pmid: 12349870
references.citation: Child Dev. 2009 Jul-Aug;80(4):1147-62
references.pmid: 19630899
references.citation: Psychiatry Clin Neurosci. 2007 Aug;61(4):355-63
references.pmid: 17610659
references.citation: J Child Psychol Psychiatry. 1994 Jan;35(1):3-28
references.pmid: 8163629
references.citation: Cogn Emot. 2007 Sep;21(6):1184-1211
references.pmid: 18509504
references.citation: Curr Opin Neurobiol. 2007 Apr;17(2):251-7
references.pmid: 17383865
references.citation: J Cogn Neurosci. 2006 Mar;18(3):430-43
references.pmid: 16513007
references.citation: Behav Cogn Neurosci Rev. 2004 Jun;3(2):71-100
references.pmid: 15537986
references.citation: Neuropsychologia. 2008 Sep;46(11):2607-14
references.pmid: 18573266
references.citation: Pain. 2006 Nov;125(1-2):5-9
references.pmid: 16997470
references.citation: Neuroimage. 2000 Feb;11(2):157-66
references.pmid: 10679187
references.citation: Dev Psychol. 1999 Mar;35(2):418-26
references.pmid: 10082012
references.citation: J Psychiatr Res. 2006 Mar;40(2):112-21
references.pmid: 16176819
references.citation: Child Dev. 2009 Jul-Aug;80(4):1197-209
references.pmid: 19630902
references.citation: Nat Rev Neurosci. 2009 Jan;10(1):37-47
references.pmid: 19050711
references.citation: Emotion. 2008 Dec;8(6):737-52
references.pmid: 19102585
references.citation: Dev Sci. 2010 Nov;13(6):886-99
references.pmid: 20977559