Neurologic manifestations of pediatric novel h1n1 influenza infection.
Reported neurologic manifestations of novel H1N1 influenza have included seizure, meningoencephalitis, and acute necrotizing encephalopathy. We describe the first series of pediatric patients presenting during the second wave of the US novel H1N1 pandemic, with protracted seizures, severe encephalopathy/encephalitis, and acute disseminated encephalomyelitis. In addition to prominent radiographic abnormalities, we provide the first observation and description of associated cerebrospinal fluid abnormalities.
Rellosa
Neil
N
Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC, USA.
Bloch
Karen C
KC
Shane
Andi L
AL
Debiasi
Roberta L
RL
D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000821:virology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000473:pathology / Q000821:virology*; D008297:Male; D008590:Meningoencephalitis / Q000473:pathology / Q000821:virology*; D012640:Seizures / Q000473:pathology / Q000821:virology*; D014481:United States