title: General anesthetic actions on GABA(A) receptors.
abstract: General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor. In this review we will discuss what is known about anesthetic - GABA(A) receptor interactions.
authors.affiliation: Departments of Anesthesiology and Pharmacology, Emory University, School of Medicine, Rollins Research Center #5013, 1510 Clifton Rd NE, Atlanta GA, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Garcia
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kolesky
authors.forename: Andrew
authors.initials: A
authors.lastname: Jenkins
references.citation: Neuropharmacology. 2002 Sep;43(4):669-78
references.pmid: 12367612
references.citation: Anesthesiology. 1998 Dec;89(6):1480-8
references.pmid: 9856723
references.citation: Anasthesiol Intensivmed Notfallmed Schmerzther. 2000 Dec;35(12):731-43
references.pmid: 11194514
references.citation: FASEB J. 1989 May;3(7):1850-4
references.pmid: 2541038
references.citation: Neuropharmacology. 2001 Dec;41(8):952-64
references.pmid: 11747900
references.citation: Mol Pharmacol. 1995 Feb;47(2):213-7
references.pmid: 7870027
references.citation: Neuropharmacology. 2002 Mar;42(4):502-21
references.pmid: 11955521
references.citation: Anesth Analg. 2008 Aug;107(2):507-24
references.pmid: 18633029
references.citation: Neuroreport. 1993 Feb;4(2):187-90
references.pmid: 8384024
references.citation: J Neurosci. 2009 Feb 18;29(7):2177-87
references.pmid: 19228970
references.citation: Neurochem Res. 2006 Mar;31(3):439-48
references.pmid: 16733821
references.citation: BMC Pharmacol. 2007 Feb 24;7:2
references.pmid: 17319964
references.citation: J Biol Chem. 2003 Oct 31;278(44):42821-8
references.pmid: 12939268
references.citation: Trends Neurosci. 1995 Dec;18(12):549-53
references.pmid: 8638296
references.citation: J Neurosci. 2004 Sep 29;24(39):8454-8
references.pmid: 15456818
references.citation: J Pharmacol Exp Ther. 1995 Aug;274(2):962-8
references.pmid: 7636760
references.citation: J Neurosci. 2005 Dec 14;25(50):11513-20
references.pmid: 16354909
references.citation: Neuropharmacology. 2009 Jan;56(1):141-8
references.pmid: 18760291
references.citation: J Neurosci. 1992 Mar;12(3):1063-76
references.pmid: 1312132
references.citation: Brain Res. 2006 Mar 17;1078(1):60-70
references.pmid: 16490182
references.citation: Anesthesiology. 1998 Mar;88(3):708-17
references.pmid: 9523815
references.citation: Toxicol Lett. 1998 Nov 23;100-101:51-8
references.pmid: 10049180
references.citation: Genes Brain Behav. 2005 Feb;4(1):10-9
references.pmid: 15660664
references.citation: J ECT. 2008 Sep;24(3):208-23
references.pmid: 18628717
references.citation: Anesth Analg. 2009 Feb;108(2):484-90
references.pmid: 19151276
references.citation: J Neurochem. 1983 Aug;41(2):578-85
references.pmid: 6308164
references.citation: Anesthesiology. 2001 Feb;94(2):340-7
references.pmid: 11176100
references.citation: Anesth Analg. 2008 Aug;107(2):486-93
references.pmid: 18633027
references.citation: Mol Pharmacol. 2001 Apr;59(4):814-24
references.pmid: 11259626
references.citation: J Pharmacol Exp Ther. 1996 Apr;277(1):411-6
references.pmid: 8613949
references.citation: J Neurochem. 2006 Feb;96(3):885-92
references.pmid: 16405501
references.citation: Mol Pharmacol. 1993 Sep;44(3):628-32
references.pmid: 7690453
references.citation: Anesth Analg. 2008 Aug;107(2):494-506
references.pmid: 18633028
references.citation: Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11031-6
references.pmid: 9380754
references.citation: J Neurosci. 2009 Oct 14;29(41):12757-63
references.pmid: 19828786
references.citation: Nat Neurosci. 2002 Oct;5(10):979-84
references.pmid: 12195434
references.citation: J Biol Chem. 2003 Sep 5;278(36):34079-83
references.pmid: 12826676
references.citation: Br J Pharmacol. 1997 Mar;120(5):749-56
references.pmid: 9138677
references.citation: Anesth Analg. 2004 Jul;99(1):85-90
references.pmid: 15281509
references.citation: Mol Pharmacol. 1997 Mar;51(3):484-90
references.pmid: 9058604
references.citation: Anesthesiology. 2006 Jun;104(6):1176-83
references.pmid: 16732088
references.citation: Science. 2000 Oct 6;290(5489):131-4
references.pmid: 11021797
references.citation: Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303
references.pmid: 10487207
references.citation: Science. 2008 Nov 7;322(5903):876-80
references.pmid: 18988836
references.citation: Nature. 1994 Feb 17;367(6464):607-14
references.pmid: 7509043
references.citation: Anesthesiology. 2003 Sep;99(3):678-84
references.pmid: 12960553
references.citation: J Neurophysiol. 1993 Oct;70(4):1339-49
references.pmid: 7506753
references.citation: FASEB J. 2003 Feb;17(2):250-2
references.pmid: 12475885
references.citation: Anesthesiology. 1996 Mar;84(3):716-20
references.pmid: 8659800
references.citation: J Neurosci. 2009 Mar 11;29(10):3083-92
references.pmid: 19279245
references.citation: Nature. 1997 Sep 25;389(6649):385-9
references.pmid: 9311780
references.citation: Anesthesiology. 1999 Feb;90(2):484-91
references.pmid: 9952156
references.citation: Nat Neurosci. 2000 Jun;3(6):587-92
references.pmid: 10816315
references.citation: J Pharmacol Exp Ther. 2006 Sep;318(3):1094-101
references.pmid: 16728592
references.citation: Trends Pharmacol Sci. 2000 Jun;21(6):208-10
references.pmid: 10838606
references.citation: J Membr Biol. 1996 Nov;154(1):11-21
references.pmid: 8881023
references.citation: J Physiol. 2001 Dec 15;537(Pt 3):715-33
references.pmid: 11744750
references.citation: Trends Neurosci. 2004 Sep;27(9):569-75
references.pmid: 15331240
references.citation: Anesthesiology. 1999 Jun;90(6):1714-22
references.pmid: 10360871
references.citation: J Biol Chem. 2004 Oct 1;279(40):41422-35
references.pmid: 15258161
references.citation: J Pharmacol Exp Ther. 2001 Apr;297(1):338-51
references.pmid: 11259561
references.citation: Brain Res. 1998 Feb 16;784(1-2):179-87
references.pmid: 9518600
references.citation: Br J Pharmacol. 1991 Nov;104(3):619-28
references.pmid: 1665745
references.citation: Br J Pharmacol. 1994 Jul;112(3):906-10
references.pmid: 7921619
references.citation: Anesth Analg. 2008 Aug;107(2):479-85
references.pmid: 18633026
references.citation: Ann Pharmacother. 2009 Nov;43(11):1802-8
references.pmid: 19826098
references.citation: J Pharmacol Exp Ther. 1995 Jul;274(1):353-60
references.pmid: 7616420
references.citation: J Neurosci. 2001 Mar 15;21(6):RC136
references.pmid: 11245705
references.citation: Neuropharmacology. 2009 Feb;56(2):438-47
references.pmid: 18948126
references.citation: J Pharmacol Exp Ther. 2006 Oct;319(1):208-18
references.pmid: 16807363
references.citation: Anesthesiology. 1970 Jul;33(1):5-9
references.pmid: 4393418
references.citation: J Neurosci. 1992 Mar;12(3):1040-62
references.pmid: 1312131
references.citation: Anesthesiology. 2007 Sep;107(3):412-8
references.pmid: 17721243