[Influence of donor age on graft survival].
BACKGROUND
In 2007 in Spain 43% of donors were older than 60 years. This produces a worse graft quality and probably a worse survival.


OBJECTIVE
Our objective is to analyze the influence of donor age on graft survival.


METHODS
We analyze retrospectively 216 renal consecutive transplants realized between 2000 and 2008. A univaried and multivaried study (Cox regression) was performed and Kaplan-Meyer test with log rank for graft survival.


RESULTS
Follow-up mean of 40 months (+/-33,4 SD). The univaried analysis of graft survival showed that donor age had a significative influence on graft survival. (OR=1,03; 95% CI 1,01-1,05) (p: 0,009). Studying the relation between donor and recipient age we find an inverse correlation (Pearson's Correlation: 0,55. p<0,0001), but there are significative differences after the adjustment for recipient age. (OR: 1,02; 95% CI 1,01-1,04) (p: 0,04). Optimal cut-point value determined by the ROC analysis was 60 years. The graft survival of donors over 60 years is 79% (95% CI; 74-84%) and 71% (95% CI; 65-77%) at 3 and 5 years in contrast with 94% (95% CI; 94-96%) and 90% (95% CI; 88-92 in donors under 60. (p: 0,002). The multivaried study of the influential factors on graft survival reveals that donor age dichotomized in older or younger than 60, the presence of a surgical immediate reintervention and a delayed graft function were independent influence factors.


CONCLUSIONS
Donor age over 60 years has a negative and independent prognostic influence on graft survival.
Barba Abad
J
J
Servicio de Urología, Clínica Universidad de Navarra, Pamplona, España. javiferbar@hotmail.com
Tolosa Eizaguirre
E
E
Rincón Mayans
A
A
Rosell Costa
D
D
Robles García
J E
JE
Zudaire Bergera
J
J
Berián Polo
J M
JM
Pascual Piedrola
I
I
D000367:Age Factors; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008875:Middle Aged; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*