Changes in serum TSH and free T4 during human sleep restriction.
OBJECTIVE
To examine whether recurrent sleep restriction is accompanied by changes in measures of thyroid function.


METHODS
Two-period crossover intervention study.


METHODS
University clinical research center and sleep laboratory.


METHODS
11 healthy volunteers (5F/6M) with a mean (+/- SD) age of 39 +/- 5 y and BMI 26.5 +/- 1.5 kg/m2.


METHODS
Randomized exposure to 14 days of sedentary living with ad libitum food intake and 5.5- vs. 8.5-h overnight sleep opportunity.


RESULTS
Serum thyroid-stimulating hormone (TSH) and free thyroxine (T4) were measured at the end of each intervention. Partial sleep restriction was accompanied by a modest but statistically significant reduction in TSH and free T4, seen mainly in the female participants of the study.


CONCLUSIONS
Compared to the well-known rise in TSH and thyroid hormone concentrations during acute sleep loss, tests obtained after 14 days of partial sleep restriction did not show a similar activation of the human thyroid axis.
Kessler
Lynn
L
Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Nedeltcheva
Arlet
A
Imperial
Jacqueline
J
Penev
Plamen D
PD
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D012016:Reference Values; D012892:Sleep Deprivation / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
D013972:Thyrotropin; D013974:Thyroxine
Neuro Endocrinol Lett. 2002 Apr;23 Suppl 1:73-8
12019356
J Clin Endocrinol Metab. 1990 Feb;70(2):403-9
2105332
Lancet. 1999 Oct 23;354(9188):1435-9
10543671
Am J Clin Nutr. 2009 Jan;89(1):126-33
19056602
J Clin Endocrinol Metab. 1987 Jan;64(1):157-61
3782430
J Clin Endocrinol Metab. 2009 Sep;94(9):3242-50
19567526
Endocrinology. 1990 Aug;127(2):882-90
2373059
J Clin Endocrinol Metab. 1973 Nov;37(5):736-40
4127181
Endocrinology. 1995 Apr;136(4):1426-34
7895653
Biol Psychiatry. 1996 May 15;39(10):857-64
9172706
Endocrinology. 1984 Jan;114(1):280-6
6317348
Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E85-93
12067847
Sleep Med Rev. 2008 Aug;12(4):289-98
18485764
Sleep. 1989 Feb;12(1):31-41
2538910