title: Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives.
abstract: Several novel molecules, 1-(3'-(9H-carbazol-4-yloxy)-2'-hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a-g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a-g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK-N-SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK-N-SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK-N-SH cell growth.
authors.affiliation: Organic Division-II, Indian Institute of Chemical Technology, Hyderabad-500607, India. lnagarapuiict@yahoo.co.in
authors.forename: Lingaiah
authors.initials: L
authors.lastname: Nagarapu
authors.forename: Hanmant K
authors.initials: HK
authors.lastname: Gaikwad
authors.forename: Kartheeka
authors.initials: K
authors.lastname: Sarikonda
authors.forename: Jhansi
authors.initials: J
authors.lastname: Mateti
authors.forename: Rajashaker
authors.initials: R
authors.lastname: Bantu
authors.forename: P S
authors.initials: PS
authors.lastname: Raghu
authors.forename: Krishna Madhuri
authors.initials: KM
authors.lastname: Manda
authors.forename: Shasi Vardhan
authors.initials: SV
authors.lastname: Kalvendi
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002264:Carboxylic Acids; D011720:Pyrazoles