Microfluidic characterization of sustained solute release from porous supraparticles.
We present a novel microfluidic technique for precise characterization of controlled release of solute from porous latex supraparticles in a laminar flow environment. Dye-infused supraparticles are fabricated via dry self-assembly method using droplet templates dispensed on superhydrophobic substrates. A water-soluble dye is used as a model compound, the release rate of which is measured colorimetrically. The sustained release rates of dye from supraparticles and dye pellets are quantified and compared to common diffusion/dissolution mass transfer models. The results illustrate the potential of microfluidics as a tool in monitoring controlled release process and the role of the uniformly porous supraparticle matrix for the prolonged continuous solute delivery.
Rastogi
Vinayak
V
Department of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA.
Velikov
Krassimir P
KP
Velev
Orlin D
OD
D004396:Coloring Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D004867:Equipment Design; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*; D008863:Microspheres; D016062:Porosity
D004396:Coloring Agents; D003692:Delayed-Action Preparations