title: Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.
abstract: Two series of some new 2,4,6-trisubstituted-quinazoline derivatives were prepared and screened for their analgesic, anti-inflammatory activity and acute toxicity. Four compounds were more potent analgesic agents than the reference drug Indomethacin and thirteen compounds showed significant anti-inflammatory activity. Seven compounds showed combined ability to inhibit both pain and inflammation. Compounds tested for acute toxicity showed no toxic symptoms or mortality rates 24 h post-administration implying their good safety margin.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia. sihmaid@students.latrobe.edu.au
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Alafeefy
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Kadi
authors.forename: Omar A
authors.initials: OA
authors.lastname: Al-Deeb
authors.forename: Kamal E H
authors.initials: KE
authors.lastname: El-Tahir
authors.forename: Nabila A
authors.initials: NA
authors.lastname: Al-Jaber
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011799:Quinazolines