title: Débridement of the noninfected wound.
abstract: The utility of wound débridement has expanded to include the management of all chronic wounds, even in the absence of infection and gross necrosis. Biofilm, metalloproteases on the wound base, and senescent cells at the wound edge irreversibly change the physiology of wound healing and contribute to a pathologic, chronic inflammatory environment. The objective of this review is to provide surgeons with a baseline understanding of the processes of débridement in the noninfected wound.
authors.affiliation: Diabetic Limb Salvage, Department of Plastic Surgery, Georgetown University Medical Center, Washington, DC 20007, USA.
authors.forename: Rhonda S
authors.initials: RS
authors.lastname: Cornell
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Meyr
authors.forename: John S
authors.initials: JS
authors.lastname: Steinberg
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Attinger
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D003646:Debridement / Q000379:methods; D017719:Diabetic Foot / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing; D014946:Wound Infection / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery