title: Born to run: creating the muscle fiber.
abstract: From the muscles that control the blink of your eye to those that allow you to walk, the basic architecture of muscle is the same: muscles consist of bundles of the unit muscle cell, the muscle fiber. The unique morphology of the individual muscle fiber is dictated by the functional demands necessary to generate and withstand the forces of contraction, which in turn leads to movement. Contractile muscle fibers are elongated, syncytial cells, which interact with both the nervous and skeletal systems to govern body motion. In this review, we focus on three key cell-cell and cell-matrix contact processes, that are necessary to create this exquisitely specialized cell: cell fusion, cell elongation, and establishment of a myotendinous junction. We address these processes by highlighting recent findings from the Drosophila model system.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. eyal.schejter@weizmann.ac.il
authors.forename: Eyal D
authors.initials: ED
authors.lastname: Schejter
authors.forename: Mary K
authors.initials: MK
authors.lastname: Baylies
mesh_terms: D000818:Animals; D004330:Drosophila; D006801:Humans; D008954:Models, Biological; D018485:Muscle Fibers, Skeletal / Q000502:physiology*
references.citation: Sci Signal. 2010 Apr 20;3(118):jc2
references.pmid: 20407122
references.citation: Dev Cell. 2007 Apr;12(4):571-86
references.pmid: 17419995
references.citation: Cell Cycle. 2010 Apr 1;9(7):1263-9
references.pmid: 20372059
references.citation: Development. 1990 Nov;110(3):791-804
references.pmid: 2100994
references.citation: J Muscle Res Cell Motil. 2003;24(4-6):301-8
references.pmid: 14620743
references.citation: Development. 2007 Apr;134(7):1269-78
references.pmid: 17314133
references.citation: Development. 1994 Jul;120(7):1747-58
references.pmid: 7924982
references.citation: Genes Dev. 1997 Oct 15;11(20):2691-700
references.pmid: 9334331
references.citation: Int Rev Neurobiol. 2006;75:55-70
references.pmid: 17137923
references.citation: Development. 1998 May;125(9):1679-89
references.pmid: 9521906
references.citation: Development. 2009 Apr;136(7):1159-68
references.pmid: 19270174
references.citation: Fly (Austin). 2010 Apr-Jun;4(2):145-8
references.pmid: 20081356
references.citation: Dev Biol. 2000 Jul 1;223(1):1-16
references.pmid: 10864456
references.citation: Curr Opin Cell Biol. 2009 Dec;21(6):754-60
references.pmid: 19896355
references.citation: Dev Biol. 2007 Nov 15;311(2):423-33
references.pmid: 17936269
references.citation: Nat Cell Biol. 2009 Jul;11(7):873-80
references.pmid: 19503073
references.citation: Development. 2010 Mar;137(5):785-94
references.pmid: 20110313
references.citation: Nat Cell Biol. 2008 Apr;10(4):422-8
references.pmid: 18327251
references.citation: Cell Cycle. 2008 Dec 15;7(24):3935-42
references.pmid: 19098426
references.citation: Nature. 2007 Jul 12;448(7150):151-6
references.pmid: 17625558
references.citation: J Cell Biol. 2007 Dec 31;179(7):1583-97
references.pmid: 18166658
references.citation: Exp Cell Res. 2010 Nov 1;316(18):3007-13
references.pmid: 20580706
references.citation: Mol Cell Biol. 2006 Dec;26(24):9442-55
references.pmid: 17030600
references.citation: Development. 1991 Sep;113(1):79-89
references.pmid: 1765010
references.citation: Dev Cell. 2007 Apr;12(4):557-69
references.pmid: 17419994
references.citation: Nat Neurosci. 2005 Jul;8(7):906-15
references.pmid: 15965473
references.citation: Trends Genet. 1999 Nov;15(11):448-53
references.pmid: 10529807
references.citation: Development. 2004 Sep;131(18):4501-9
references.pmid: 15342475
references.citation: J Cell Biol. 1999 Apr 5;145(1):191-201
references.pmid: 10189378
references.citation: EMBO Rep. 2009 Sep;10(9):1043-50
references.pmid: 19644501
references.citation: Proc Natl Acad Sci U S A. 2006 May 16;103(20):7841-6
references.pmid: 16682643
references.citation: Development. 2009 Oct;136(19):3323-33
references.pmid: 19736327
references.citation: EMBO J. 2006 Aug 9;25(15):3640-51
references.pmid: 16858411
references.citation: Mech Dev. 2007 Jul;124(6):463-75
references.pmid: 17482800
references.citation: J Cell Sci. 2009 Apr 15;122(Pt 8):1071-9
references.pmid: 19339546
references.citation: Bioessays. 2010 Feb;32(2):100-8
references.pmid: 20091751
references.citation: Curr Opin Genet Dev. 2001 Aug;11(4):431-9
references.pmid: 11448630
references.citation: Nat Rev Neurosci. 2009 Jan;10(1):9-22
references.pmid: 19096367
references.citation: Int J Biochem Cell Biol. 2004 Jun;36(6):961-8
references.pmid: 15094109
references.citation: Development. 2009 Nov;136(21):3607-15
references.pmid: 19793885
references.citation: Nat Genet. 2007 Jun;39(6):781-6
references.pmid: 17529975
references.citation: Genes Dev. 2004 Jan 15;18(2):223-37
references.pmid: 14729572
references.citation: Curr Opin Genet Dev. 2006 Oct;16(5):533-9
references.pmid: 16919443
references.citation: Cell Adh Migr. 2010 Jul-Sep;4(3):368-71
references.pmid: 20404543
references.citation: Dev Cell. 2004 Jul;7(1):9-20
references.pmid: 15239950
references.citation: Dev Cell. 2002 Sep;3(3):311-21
references.pmid: 12361595
references.citation: Development. 2001 Dec;128(24):5061-73
references.pmid: 11748142
references.citation: Development. 2006 Aug;133(16):3255-64
references.pmid: 16854971
references.citation: Cell. 2005 Feb 11;120(3):421-33
references.pmid: 15707899
references.citation: Development. 2007 Dec;134(24):4357-67
references.pmid: 18003739
references.citation: J Anat. 2005 Dec;207(6):735-44
references.pmid: 16367801
references.citation: Dev Biol. 2010 May 1;341(1):66-83
references.pmid: 19932206
references.citation: Cell. 2003 Sep 19;114(6):751-62
references.pmid: 14505574
references.citation: J Cell Sci. 2005 Nov 15;118(Pt 22):5381-92
references.pmid: 16280552
references.citation: Curr Opin Genet Dev. 1999 Oct;9(5):522-9
references.pmid: 10508697
references.citation: Development. 1994 May;120(5):1221-31
references.pmid: 8026331
references.citation: Dev Cell. 2006 Jun;10(6):797-807
references.pmid: 16740481
references.citation: J Cell Sci. 2008 Apr 15;121(Pt 8):1303-13
references.pmid: 18388318
references.citation: J Cell Biol. 2001 Mar 5;152(5):1007-18
references.pmid: 11238456
references.citation: Dev Dyn. 2007 Dec;236(12):3332-42
references.pmid: 17948301
references.citation: Dev Dyn. 2007 Feb;236(2):404-15
references.pmid: 17146786
references.citation: Cell. 1999 Mar 19;96(6):785-94
references.pmid: 10102267
references.citation: Dev Cell. 2001 Nov;1(5):705-15
references.pmid: 11709190
references.citation: Nature. 2009 Nov 5;462(7269):65-70
references.pmid: 19890324
references.citation: Development. 2003 Dec;130(26):6475-84
references.pmid: 14627723
references.citation: Science. 2001 Apr 27;292(5517):737-40
references.pmid: 11326102
references.citation: Cell. 1989 Feb 10;56(3):401-8
references.pmid: 2492451
references.citation: J Cell Biol. 1999 Jul 26;146(2):465-75
references.pmid: 10427098
references.citation: Traffic. 2008 Jul;9(7):1050-9
references.pmid: 18435820
references.citation: J Biol Chem. 2003 Feb 7;278(6):3590-8
references.pmid: 12458226
references.citation: Curr Pharm Des. 2010;16(8):929-41
references.pmid: 20041821
references.citation: Dev Biol. 1981 Sep;86(2):393-402
references.pmid: 6793430
references.citation: Development. 2009 May;136(9):1411-21
references.pmid: 19297411
references.citation: Dev Cell. 2007 May;12(5):751-66
references.pmid: 17488626
references.citation: Development. 2007 Dec;134(24):4469-78
references.pmid: 18039972
references.citation: Nature. 1997 Mar 20;386(6622):279-84
references.pmid: 9069286
references.citation: Dev Dyn. 2009 Jun;238(6):1513-25
references.pmid: 19418445
references.citation: Dev Biol. 2007 Sep 1;309(1):113-25
references.pmid: 17662708
references.citation: Mol Biol Evol. 2010 Sep;27(9):2187-97
references.pmid: 20427418
references.citation: PLoS Genet. 2006 Feb;2(2):e16
references.pmid: 16482229
references.citation: Dev Cell. 2001 Nov;1(5):691-703
references.pmid: 11709189
references.citation: Nature. 2010 Mar 11;464(7286):287-91
references.pmid: 20220848
references.citation: Dev Biol. 1993 May;157(1):49-59
references.pmid: 8482419
references.citation: Dev Cell. 2002 Jan;2(1):41-54
references.pmid: 11782313
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9274-9
references.pmid: 19470472
references.citation: Nat Rev Mol Cell Biol. 2010 Apr;11(4):237-51
references.pmid: 20237478
references.citation: Dev Cell. 2005 Apr;8(4):493-504
references.pmid: 15809032
references.citation: Mol Biol Evol. 2007 Nov;24(11):2525-34
references.pmid: 17890240