title: A tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one of defined relative stereochemistry for use towards Agariblazeispirol C.
abstract: Towards the synthesis of the novel natural product Agariblazeispirol C, (5aR*,11bR*)-9-methoxy-3,8,11b-trimethyl-5,6,7,11b-tetrahydro-1H-pentaleno[1,6a-a]naphthalen-4(2H)-one, C(20)H(24)O(2), has been prepared at a key stage of the preparative programme. The structure shows the desired stereochemical outcome of the central cyclization protocol, viz. a syn-relationship between the aliphatic methyl group on the 11b-position and the methylene group on the 5a-position [C-C-C-C = -34.57 (18) degrees ].
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: William J
authors.initials: WJ
authors.lastname: Kerr
authors.forename: Laura C
authors.initials: LC
authors.lastname: Paterson
authors.forename: Andrew
authors.initials: A
authors.lastname: Sutherland