title: [Participation of endotoxin from gram-negative bacteria in mechanisms of regulation of thyroid status].
abstract: Alteration of thyroid hormone blood levels in rats in different periods after exposure of high dose of lipopolysaccharide from E. coli were studied. Direct inhibition of thyroid function without hypothalamus-pituitary dysfunction is revealed. High dose by high doses of bacterial endotoxin leads to changes in rat thyroid status caused by both hypothalamus-pituitary and thyroid hypofunction.
authors.forename: N V
authors.initials: NV
authors.lastname: Iaglova
authors.forename: T T
authors.initials: TT
authors.lastname: Berezov
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism* / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology* / Q000503:physiopathology
chemical_list: D008070:Lipopolysaccharides; C433788:lipopolysaccharide, E. coli O26-B6