title: Progesterone intoxication inducing marked sedation in a cat.
abstract: A 3-year-old, male castrated domestic shorthair cat presented for sudden onset of severe lethargy and loss of balance a few hours after potentially ingesting capsules containing progesterone. Elevated serum progesterone was confirmed. Supportive care and time resulted in complete resolution of the clinical signs with no long-term complications or recurrence of clinical signs noticed after 1-month follow-up. This is the first description of progesterone intoxication inducing neurological signs in a cat.
authors.affiliation: Western College of Veterinary Medicine, University of Saskatchewan, Department of Small Animal Clinical Sciences, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada. marc.dhumeaux@usask.ca
authors.forename: Marc P
authors.initials: MP
authors.lastname: Dhumeaux
authors.forename: Elisabeth C R
authors.initials: EC
authors.lastname: Snead
authors.forename: Germaine C
authors.initials: GC
authors.lastname: Hung
authors.forename: Susan M
authors.initials: SM
authors.lastname: Taylor
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000628:therapy; D002415:Cats; D005500:Follow-Up Studies; D053609:Lethargy / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D004856:Postural Balance / Q000187:drug effects; D011374:Progesterone / Q000506:poisoning*; D016896:Treatment Outcome
chemical_list: D011374:Progesterone
references.citation: Contracept Fertil Sex (Paris). 1985 Jan;13(1 Suppl):147-52
references.pmid: 12280201
references.citation: Acta Physiol Scand. 1987 Sep;131(1):33-42
references.pmid: 3673611
references.citation: Biochem J. 1959 Feb;71(2):411-5
references.pmid: 13628586
references.citation: Maturitas. 1982 Apr;4(1):67-72
references.pmid: 7099005
references.citation: Am J Physiol. 1997 May;272(5 Pt 1):E885-91
references.pmid: 9176190
references.citation: Vet Rec. 2001 Mar 17;148(11):346-7
references.pmid: 11316295
references.citation: Psychoneuroendocrinology. 1990;15(2):159-62
references.pmid: 2359812
references.citation: J Feline Med Surg. 2009 Jun;11(6):518-21
references.pmid: 19058986
references.citation: Gynecol Endocrinol. 2010 Feb;26(2):81-5
references.pmid: 19995152
references.citation: Climacteric. 2008 Jun;11(3):233-43
references.pmid: 18568788
references.citation: Am J Physiol. 1996 Oct;271(4 Pt 1):E763-72
references.pmid: 8897866
references.citation: J Feline Med Surg. 2005 Feb;7(1):43-52
references.pmid: 15686973
references.citation: Can Vet J. 2003 Mar;44(3):227-9
references.pmid: 12677692
references.citation: J Neuroendocrinol. 1995 Mar;7(3):171-7
references.pmid: 7606242
references.citation: Curr Neurol Neurosci Rep. 2009 Mar;9(2):165-72
references.pmid: 19268040
references.citation: Nurs Clin North Am. 2004 Mar;39(1):97-115
references.pmid: 15062730
references.citation: Horm Res. 1998;49(3-4):125-30
references.pmid: 9550112
references.citation: Vet Pathol. 1989 Mar;26(2):104-13
references.pmid: 2711568
references.citation: Brain Res. 1993 Jul 2;615(2):267-74
references.pmid: 8395958
references.citation: Headache. 2007 Sep;47 Suppl 2:S68-78
references.pmid: 17850537
references.citation: Am J Obstet Gynecol. 1988 Nov;159(5):1203-9
references.pmid: 3189454
references.citation: Philipp J Ophthalmol. 1981 Jan-Mar;13(1):19-21
references.pmid: 12339685
references.citation: Pharmacol Biochem Behav. 1993 Jun;45(2):423-8
references.pmid: 8392205
references.citation: J Endocrinol. 1957 Jan;14(4):371-5
references.pmid: 13398530
references.citation: Ann Emerg Med. 2008 Feb;51(2):164-72
references.pmid: 17588708