title: [Vitamin K and fracture].
abstract: Vitamin K is well known for its role in the synthesis of a number of blood coagulation factors. Vitamin K is also an important factor for bone metabolism via gamma-carboxylation of vitamin K-dependent proteins such as osteocalcin, matrix Gla protein, and protein S. Recent studies suggest that there is potential vitamin K insufficiency in bone, even in sufficient vitamin K status for blood coagulation. In the present review, the studies concerning relationship between vitamin K status and fracture are reviewed.
authors.affiliation: Department of Hygienic Sciences, Kobe Pharmaceutical University.
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsugawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Okano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002135:Calcium-Binding Proteins / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D050723:Fractures, Bone / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D014812:Vitamin K / Q000008:administration & dosage* / Q000502:physiology; D014813:Vitamin K Deficiency / Q000150:complications; D055815:Young Adult; D000097568:Matrix Gla Protein
chemical_list: D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D015675:Osteocalcin; D014812:Vitamin K; D000097568:Matrix Gla Protein