Autism and mitochondrial disease.
Autism spectrum disorder (ASD) as defined by the revised Diagnostic and Statistical Manual of Mental Disorders: DSM IVTR criteria (American Psychiatric Association [2000] Washington, DC: American Psychiatric Publishing) as impairment before the age of 3 in language development and socialization with the development of repetitive behaviors, appears to be increased in incidence and prevalence. Similarly, mitochondrial disorders are increasingly recognized. Although overlap between these disorders is to be expected, accumulating clinical, genetic, and biochemical evidence suggests that mitochondrial dysfunction in ASD is more commonly seen than expected. Some patients with ASD phenotypes clearly have genetic-based primary mitochondrial disease. This review will examine the data linking autism and mitochondria.
Haas
Richard H
RH
Department of Neurosciences, UCSD Mitochondrial and Metabolic Disease Center, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. rhaas@ucsd.edu
D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D002675:Child, Preschool; D002869:Chromosome Aberrations; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005838:Genotype; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D010085:Oxidative Phosphorylation; D010641:Phenotype
D004272:DNA, Mitochondrial; D019344:Lactic Acid