Iron-catalyzed heterocycle and arene deprotonative alkylation.
A method for iron-catalyzed deprotonative alkylation of arene C-H bonds by alkyl iodides and bromides has been developed. In the presence of an amide base, both primary and secondary alkyl halides can be coupled with furans, thiophenes, pyridine derivatives, and some electron-withdrawing-group containing arenes.
Tran
Ly Dieu
LD
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
Daugulis
Olafs
O
D000478:Alkylation; D002384:Catalysis; D006219:Halogens / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D011522:Protons
D006219:Halogens; D006571:Heterocyclic Compounds; D011522:Protons; D007501:Iron
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