title: Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis.
abstract: BACKGROUND
  Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored.
  
  
  METHODS
  The study included 2,589 incident primary melanoma patients with assessment of histologic solar elastosis in the population-based Genes, Environment, and Melanoma study. Ambient erythemal UV (UVE) at places of residence and sun exposure hours, including body site-specific exposure, were collected. We examined the association of cumulative site-specific and non-site-specific sun exposure hours and ambient UVE with solar elastosis in multivariable models adjusted for age, sex, center, pigmentary characteristics, nevi, and, where relevant, body site.
  
  
  RESULTS
  Solar elastosis was associated most strongly with site-specific UVE [odds ratio (OR) for top exposure quartile, 5.20; 95% confidence interval (95% CI), 3.40-7.96; P for trend <0.001] and also with site-specific sun exposure (OR for top quartile, 5.12; 95% CI, 3.35-7.83; P for trend <0.001). Older age (OR at >70 years, 7.69; 95% CI, 5.14-11.52; P for trend < 0.001) and having more than 10 back nevi (OR, 0.77; 95% CI, 0.61-0.97; P = 0.03) were independently associated with solar elastosis.
  
  
  CONCLUSIONS
  Solar elastosis had a strong association with higher site-specific UVE dose, older age, and fewer nevi.
  
  
  CONCLUSIONS
  Solar elastosis could be a useful biomarker of lifetime site-specific UV. Future research is needed to explore whether age represents more than simple accumulation of sun exposure and to determine why people with more nevi may be less prone to solar elastosis.
authors.affiliation: Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA. nthomas@med.unc.edu
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Thomas
authors.forename: Anne
authors.initials: A
authors.lastname: Kricker
authors.forename: Lynn
authors.initials: L
authors.lastname: From
authors.forename: Klaus
authors.initials: K
authors.lastname: Busam
authors.forename: Robert C
authors.initials: RC
authors.lastname: Millikan
authors.forename: Mary E
authors.initials: ME
authors.lastname: Ritchey
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Armstrong
authors.forename: Julia
authors.initials: J
authors.lastname: Lee-Taylor
authors.forename: Loraine D
authors.initials: LD
authors.lastname: Marrett
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.forename: Roberto
authors.initials: R
authors.lastname: Zanetti
authors.forename: Stefano
authors.initials: S
authors.lastname: Rosso
authors.forename: Richard P
authors.initials: RP
authors.lastname: Gallagher
authors.forename: Terence
authors.initials: T
authors.lastname: Dwyer
authors.forename: Chris
authors.initials: C
authors.lastname: Goumas
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kanetsky
authors.forename: Colin B
authors.initials: CB
authors.lastname: Begg
authors.forename: Irene
authors.initials: I
authors.lastname: Orlow
authors.forename: Homer
authors.initials: H
authors.lastname: Wilcox
authors.forename: Susan
authors.initials: S
authors.lastname: Paine
authors.forename: Marianne
authors.initials: M
authors.lastname: Berwick
mesh_terms: D000367:Age Factors; D004547:Elastic Tissue / Q000473:pathology* / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology; D012880:Skin Pigmentation; D013472:Sunlight / Q000009:adverse effects*
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