A mimic of the pyruvate dehydrogenase complex.
Pyruvic acid undergo decarboxylation catalyzed by a hydrophobic thiazolium salt and reacts with a hydrophobic analog of lipoic acid to form a hydrophobic acylthioester that reacts with aniline to form acetanilide in water, but only in the presence of a hydrophobically modified polyaziridine that acts to gather the reactants just as the enzyme complex does.
Zhao
Huanyu
H
Department of Chemistry, Columbia University, New York, NY 10027, USA.
Breslow
Ronald
R
D000083:Acetanilides / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D002384:Catalysis; D003653:Decarboxylation; D011094:Polyethyleneimine / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D019289:Pyruvic Acid / Q000378:metabolism*; D013440:Sulfides / Q000737:chemistry / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry / Q000378:metabolism; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000378:metabolism*
D000083:Acetanilides; D000814:Aniline Compounds; D011768:Pyruvate Dehydrogenase Complex; D013440:Sulfides; D013844:Thiazoles; D008063:Thioctic Acid; D019289:Pyruvic Acid; D011094:Polyethyleneimine; C023650:aniline; C508827:acetanilide