title: Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress.
abstract: Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease. The present study was designed to investigate the neuroprotective effects of Centella asiatica against colchicine-induced memory impairment and oxidative damage in rats. Colchicine (15 mug/5 muL) was administered intracerebroventricularly in the lateral ventricle of male wistar rats. Morris water maze and plus-maze performance tests were used to assess memory performance tasks. Various biochemical parameters such as lipid peroxidation, nitrite, reduced glutathione, glutathione-S-transferase, superoxide dismutase, acetylcholinesterase were also assessed. ICV colchicine resulted marked memory impairment and oxidative damage. Chronic treatment with Centella asiatica extract (150 and 300 mg/kg, p.o.) for a period of 25 days, beginning 4 days prior to colchicine administration, significantly attenuated colchicine-induced memory impairment and oxidative damage. Besides, Centella asiatica significantly reversed colchicines administered increase in acetylcholinesterase activity. Thus, present study indicates protective effect of Centella asiatica against colchicine-induced cognitive impairment and associated oxidative damage.
authors.affiliation: Pharmacology Division, UGC Center of Advanced Study, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Samrita
authors.initials: S
authors.lastname: Dogra
authors.forename: Atish
authors.initials: A
authors.lastname: Prakash
references.citation: Brain Res Bull. 2000 Jul 15;52(5):435-43
references.pmid: 10922524
references.citation: Arch Biochem Biophys. 1959 May;82(1):70-7
references.pmid: 13650640
references.citation: Ann Neurol. 1995 Sep;38(3):357-66
references.pmid: 7668820
references.citation: Mol Aspects Med. 2004 Feb-Apr;25(1-2):117-23
references.pmid: 15051321
references.citation: Anal Biochem. 1982 Oct;126(1):131-8
references.pmid: 7181105
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 1992 Jan;16(1):117-25
references.pmid: 1557503
references.citation: Zhong Xi Yi Jie He Xue Bao. 2007 May;5(3):348-51
references.pmid: 17498500
references.citation: Neuroscience. 1982 Mar;7(3):695-714
references.pmid: 7070670
references.citation: Biochem Pharmacol. 1961 Jul;7:88-95
references.pmid: 13726518
references.citation: Ann Neurol. 2006 Feb;59(2):219-28
references.pmid: 16402383
references.citation: Brain Res Brain Res Rev. 1997 Dec;25(3):335-58
references.pmid: 9495562
references.citation: Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9866-8
references.pmid: 9275217
references.citation: Ann Clin Psychiatry. 2005 Oct-Dec;17(4):269-86
references.pmid: 16402761
references.citation: Planta Med. 2004 Dec;70(12):1150-4
references.pmid: 15643549
references.citation: J Ethnopharmacol. 2002 Feb;79(2):253-60
references.pmid: 11801389
references.citation: Biochem J. 1966 Jun;99(3):667-76
references.pmid: 5964963
references.citation: Int Rev Cytol Suppl. 1978;(7):373-402
references.pmid: 79566
references.citation: Neurobiol Aging. 2001 Nov-Dec;22(6):993-1005
references.pmid: 11755008
references.citation: J Neurosci. 1997 Apr 15;17(8):2653-7
references.pmid: 9092586
references.citation: Brain Res Brain Res Rev. 2005 Jul;49(1):1-21
references.pmid: 15960984
references.citation: J Med Food. 2007 Sep;10(3):486-94
references.pmid: 17887943
references.citation: Trends Neurosci. 1998 Oct;21(10):428-33
references.pmid: 9786340
references.citation: Toxicology. 2006 Dec 7;228(2-3):259-68
references.pmid: 17084010
references.citation: Evid Based Complement Alternat Med. 2006 Sep;3(3):349-57
references.pmid: 16951719
references.citation: Methods Enzymol. 1981;77:398-405
references.pmid: 7329316
references.citation: Proc Soc Exp Biol Med. 1995 Apr;208(4):337-45
references.pmid: 7700883
references.citation: J Neurochem. 1997 May;68(5):2092-7
references.pmid: 9109537
references.citation: Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):367-81
references.pmid: 10817921
references.citation: Eur J Pharmacol. 2006 Dec 3;551(1-3):58-66
references.pmid: 17027965
references.citation: Behav Brain Res. 2007 Jun 18;180(2):139-45
references.pmid: 17420060
references.citation: Neurobiol Aging. 2003 Dec;24(8):1079-85
references.pmid: 14643379
references.citation: Brain Res. 1998 Jul 20;799(2):215-29
references.pmid: 9675286
references.citation: Arch Biochem Biophys. 1978 Feb;186(1):189-95
references.pmid: 24422
references.citation: Pharmacol Rep. 2007 May-Jun;59(3):274-83
references.pmid: 17652827
references.citation: Neuroreport. 1993 Dec 13;5(3):245-8
references.pmid: 8298082
references.citation: Physiol Behav. 2005 Nov 15;86(4):449-57
references.pmid: 16214185
references.citation: Drugs. 1995 Mar;49(3):345-61
references.pmid: 7774511
references.citation: Evid Based Complement Alternat Med. 2009 Jun;6(2):203-10
references.pmid: 18955230
references.citation: J Neurochem. 2006 Mar;96(5):1242-52
references.pmid: 16478524
references.citation: Pharmacol Biochem Behav. 2002 Oct;73(3):565-71
references.pmid: 12151031
references.citation: J Biol Chem. 1949 Feb;177(2):751-66
references.pmid: 18110453
references.citation: Brain Res. 1987 Apr 7;408(1-2):57-64
references.pmid: 2885069
references.citation: Curr Alzheimer Res. 2004 May;1(2):135-42
references.pmid: 15975078
references.citation: Pharmacol Biochem Behav. 1991 Jan;38(1):141-5
references.pmid: 2017442
references.citation: Fitoterapia. 2003 Jul;74(5):431-4
references.pmid: 12837356
references.citation: Brain Res. 1997 Mar 7;750(1-2):53-8
references.pmid: 9098529