title: New concepts in the diagnosis and treatment of premature ejaculation.
abstract: Premature ejaculation is the most common male sexual dysfunction. The International Society of Sexual Medicine recently defined premature ejaculation as ejaculation less than about 1 min after penetration, inability to control ejaculation, and resulting negative personal consequences. Evolving treatments target the modulation of the neurobiological causes of the disorder. Current pharmaceuticals focus on aerosolized topical agents, selective serotonin reuptake inhibitors, 5-hydroxytryptamine receptor modulators, and opioid agonists. These emerging medications and the ability to tailor treatments based on genetic information likely will change the paradigm of this disorder and how it will be treated by clinicians.
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Keel
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Dorsey
authors.forename: William
authors.initials: W
authors.lastname: Acker
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D004542:Ejaculation; D006801:Humans; D008297:Male; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis* / Q000628:therapy*; D013997:Time Factors
references.citation: Int J Impot Res. 2009 Jul-Aug;21(4):221-7
references.pmid: 19474796
references.citation: Int J Impot Res. 2004 Dec;16(6):547-51
references.pmid: 15057258
references.citation: BJU Int. 2010 Jan;105(1):73-8
references.pmid: 19549114
references.citation: J Sex Med. 2009 Jan;6(1):276-84
references.pmid: 19170855
references.citation: Psychopharmacology (Berl). 1998 Jun;137(4):374-82
references.pmid: 9676898
references.citation: J Sex Med. 2009 Feb;6(2):408-14
references.pmid: 19040619
references.citation: Br J Pharmacol. 2008 Sep;155(1):118-26
references.pmid: 18552879
references.citation: Trends Neurosci. 2007 Feb;30(2):79-84
references.pmid: 17169440
references.citation: J Sex Med. 2008 Jan;5(1):188-93
references.pmid: 17362279
references.citation: J Clin Psychopharmacol. 2006 Feb;26(1):27-31
references.pmid: 16415702
references.citation: Horm Behav. 1985 Mar;19(1):14-20
references.pmid: 2984103
references.citation: Urology. 2004 Jan;63(1):155-8
references.pmid: 14751371
references.citation: J Urol. 2002 Dec;168(6):2486-9
references.pmid: 12441946
references.citation: South Med J. 1956 Apr;49(4):353-8
references.pmid: 13311629
references.citation: J Androl. 2010 Mar-Apr;31(2):126-30
references.pmid: 19395368
references.citation: Neurochem Res. 1997 Aug;22(8):1065-70
references.pmid: 9239763
references.citation: Eur J Pharmacol. 1992 Jan 14;210(2):121-9
references.pmid: 1534765
references.citation: J Sex Med. 2010 Jan;7(1 Pt 2):414-44
references.pmid: 20092447
references.citation: J Clin Endocrinol Metab. 1987 Jan;64(1):27-31
references.pmid: 3782434
references.citation: Eur Urol. 2005 Sep;48(3):408-17
references.pmid: 15996810
references.citation: BJU Int. 2007 Feb;99(2):369-75
references.pmid: 17129234
references.citation: J Urol. 2002 May;167(5):2111-2
references.pmid: 11956452
references.citation: Zhonghua Nan Ke Xue. 2008 May;14(5):436-8
references.pmid: 18572864
references.citation: Exp Brain Res. 1992;88(2):313-20
references.pmid: 1577105
references.citation: BJU Int. 2004 May;93(7):1018-21
references.pmid: 15142155
references.citation: J Sex Marital Ther. 2003 Oct-Dec;29(5):361-70
references.pmid: 14504007
references.citation: J Urol. 1995 Oct;154(4):1360-1
references.pmid: 7658537
references.citation: J Neurosci. 2003 Oct 8;23(27):9185-93
references.pmid: 14534252
references.citation: J Clin Pharmacol. 2006 Mar;46(3):301-9
references.pmid: 16490806
references.citation: BJU Int. 2007 Mar;99(3):619-22
references.pmid: 17155977
references.citation: Int J Impot Res. 2004 Aug;16(4):369-81
references.pmid: 14961051
references.citation: J Sex Marital Ther. 2008;34(1):1-13
references.pmid: 18396725
references.citation: BJU Int. 2007 Sep;100(3):493-501
references.pmid: 17608824
references.citation: Lancet. 2006 Sep 9;368(9539):929-37
references.pmid: 16962882
references.citation: J Sex Med. 2008 Jul;5(7):1590-606
references.pmid: 18466262
references.citation: BJU Int. 1999 Jan;83 Suppl 1:79-84
references.pmid: 10349418
references.citation: J Sex Med. 2010 Aug;7(8):2860-7
references.pmid: 20367773
references.citation: J Clin Psychopharmacol. 2008 Feb;28(1):39-44
references.pmid: 18204339
references.citation: J Urol. 2002 Dec;168(6):2359-67
references.pmid: 12441918
references.citation: Behav Brain Res. 1998 May;92(2):111-8
references.pmid: 9638953
references.citation: Curr Opin Urol. 2005 Nov;15(6):399-403
references.pmid: 16205491
references.citation: BJU Int. 2009 Apr;103(7):940-9
references.pmid: 19245438
references.citation: Eur Urol. 2007 Mar;51(3):816-23; discussion 824
references.pmid: 16934919
references.citation: J Sex Med. 2010 Mar;7(3):1269-76
references.pmid: 20074312
references.citation: JAMA. 1999 Feb 10;281(6):537-44
references.pmid: 10022110
references.citation: Pharmacol Biochem Behav. 2005 Nov;82(3):427-33
references.pmid: 16253317
references.citation: Physiol Behav. 2004 Nov 15;83(2):203-15
references.pmid: 15488540