Prolonged gonadotropin stimulation is associated with decreased ART success.
OBJECTIVE
to evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART.


METHODS
all IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed.


RESULTS
out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10-12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30-0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis.


CONCLUSIONS
prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.
Chuang
Meleen
M
Department of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Zapantis
Athena
A
Taylor
Martina
M
Jindal
Sangita K
SK
Neal-Perry
Genevieve S
GS
Lieman
Harry J
HJ
Polotsky
Alex Joel
AJ
D000328:Adult; D001723:Birth Rate; D015331:Cohort Studies; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007246:Infertility / Q000628:therapy*; D050498:Live Birth; D016015:Logistic Models; D015999:Multivariate Analysis; D054315:Oocyte Retrieval; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
D007987:Gonadotropin-Releasing Hormone
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