title: [Efficacy of cytoflavine in treating traumatic toxicosis].
abstract: Experiments on rats showed that traumatic toxicosis (crush syndrome) was accompanied with hypotension, bradycardia, reduction in temperature, breath frequency, and oxygen intake, and violation of acid-base buffer state with elevation of lactate acidosis in the blood serum that is typical of shock performance. Substrate combined antihypoxant cytoflavine (1.5 ml/kg) administered systemically to rats immediately after decompression, increased percentage of survived rats and recovered the main indexes of functional systems and acid-base buffer state 12 h after trauma, which provided general protection of rats against traumatic toxicosis.
authors.forename: I V
authors.initials: IV
authors.lastname: Zarubina
authors.forename: I A
authors.initials: IA
authors.lastname: Iunusov
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003444:Crush Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009536:Niacinamide / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D019289:Pyruvic Acid / Q000097:blood; D051381:Rats; D012119:Respiration / Q000187:drug effects; D013386:Succinates / Q000627:therapeutic use*; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D019344:Lactic Acid; D005486:Flavin Mononucleotide; D019289:Pyruvic Acid; D007290:Inosine Diphosphate