[Progress of research on aspirin resistance and its related course of integrative medical research].
Aspirin is the most classic anti-platelet drug, plays its important role in preventing and treating cardio- and cerebro-vascular diseases for its excellent potency ratio; however, there exists individual difference in its anti-platelet effect, aspirin resistance (AR) presented in about 25%-40% of patients, which seriously influences the intervention effect of aspirin. So AR has become a clinical problem that attached more attention. In this paper, the authors put forward a new thinking for clinical studying and inventing new effective Chinese drugs on AR by means of screen out AR suffered from cardio/cerebro-vascular patients long-term received aspirin; find their gene difference sites from MtSNP to establish a foundation for AR predication and reasonable strategy formation; meantime, through platelet intervention in vitro adopting uniform design optimization method to explore the best compatibility and matching relationship of anti-platelet Chinese medicine for AR prevention and treatment, so as to fully display the multi-target intervening effects of Chinese drug-therapy.
Lu
Xiao-Yan
XY
National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing. deerxiaoyan@126.com
Xu
Hao
H
Chen
Ke-Ji
KJ
D001241:Aspirin / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D055048:Integrative Medicine / Q000379:methods*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012107:Research Design
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin