Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.
Ghosh
Arun K
AK
Department of Chemistry and Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. akghosh@purdue.edu
Xu
Chun-Xiao
CX
Rao
Kalapala Venkateswara
KV
Baldridge
Abigail
A
Agniswamy
Johnson
J
Wang
Yuan-Fang
YF
Weber
Irene T
IT
Aoki
Manabu
M
Miguel
Salcedo Gomez Pedro
SG
Amano
Masayuki
M
Mitsuya
Hiroaki
H
D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D000069454:Darunavir; D019281:Dimerization; D015195:Drug Design; D024921:Drug Resistance, Multiple, Viral; D005663:Furans; D015658:HIV Infections / Q000188:drug therapy*; D016333:HIV Protease / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects*; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D008024:Ligands; D011506:Proteins; D013449:Sulfonamides; C095108:amprenavir; D016333:HIV Protease; D000069454:Darunavir
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