title: Lesional skin vascular endothelial growth factor levels correlate with clinical severity in patients with cement allergic contact dermatitis.
abstract: Allergic contact dermatitis to cement is a delayed-type hypersensitivity reaction in which cytokines interferon-gamma (IEN-y) and vascular endothelial growth factor(VEGF) may be involved in persisting erythema and oedema. VEGF and IFN-gamma levels in serum and skin lesions were measured in 32 Egyptian building workers with chronic allergic contact dermatitis due to occupational exposure to cement and 20 healthy controls. Dermatitis patients had significantly higher levels of serum and lesional skin VEGF and IFN-gamma than controls. A significant positive correlation was found between tissue VEGF and the eczema area and severity index (EASI) score in dermatitis patients (r = 0.86). VEGF and IFN-gamma may play a role in the pathogenesis of cement allergic contact dermatitis.
authors.affiliation: Department of Dermatology and Andrology, Faculty of Medicine, University of Assiut, Assiut, Egypt.
authors.forename: H
authors.initials: H
authors.lastname: Zedan
authors.forename: H A
authors.initials: HA
authors.lastname: Abd El-Baset
authors.forename: A A
authors.initials: AA
authors.lastname: Abd-Elsayed
authors.forename: M F
authors.initials: MF
authors.lastname: El-Karn
authors.forename: H R H
authors.initials: HR
authors.lastname: Madkors
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D016022:Case-Control Studies; D002908:Chronic Disease; D003252:Construction Materials / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D009783:Dermatitis, Occupational / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D015536:Down-Regulation / Q000276:immunology; D004534:Egypt / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016898:Interferon-alpha / Q000032:analysis / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis* / Q000097:blood / Q000276:immunology
chemical_list: D016898:Interferon-alpha; D042461:Vascular Endothelial Growth Factor A