The relationship between the symptoms of female gonococcal infections and serum progesterone level and the genotypes of Neisseria gonorrhoeae multi-antigen sequence type (NG-MAST) in Wuhan, China.
The objective of this investigation was to study the relationship between the symptoms of female gonococcal infections and serum progesterone level and the genotypes of Neisseria gonorrhoeae multi-antigen sequence type (NG-MAST) in Wuhan, China. Eighty-one strains of N. gonorrhoeae were harvested from the vaginal discharge of 975 adult females in Wuhan and were genotyped by using NG-MAST. Serum progesterone (P) and estradiol (E(2)) levels were measured by radio immunoassay (RIA) in 39 gonorrhea-infected patients with slight symptoms (asymptomatic group) and 42 patients with conspicuous symptoms (symptomatic group). The average levels of serum progesterone in the asymptomatic group were significantly higher than in the symptomatic group (p < 0.05), while no significant difference was found in serum estradiol between the two groups. Of 81 wild-type isolates, 50 NG-MAST sequence types were associated with female infections in Wuhan, and N. gonorrhoeae ST2951, ST735, and ST436 were principally found in asymptomatic patients. ST809 and ST369, however, were mainly detected in asymptomatic female subjects. Gonococcal genetic island (GGI)-positive and GGI-negative strains were found in both the asymptomatic group and the symptomatic group. In females with gonococcal infection, high serum progesterone level is associated with the absence of symptoms, but no association was revealed between genotypes and the presence of symptoms. The GGI bears no relation to the absence of symptoms in the patients.
Wu
Z
Z
Department of Dermatology, Wuhan University of Science and Technology, Wuhan, China.
Xu
L
L
Tu
Y
Y
Chen
R
R
Yu
Y
Y
Li
J
J
Tan
M
M
Chen
H
H
D000293:Adolescent; D000328:Adult; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D015373:Bacterial Typing Techniques; D002681:China; D004958:Estradiol / Q000097:blood; D005260:Female; D005838:Genotype; D006069:Gonorrhea / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D058885:Multilocus Sequence Typing; D009344:Neisseria gonorrhoeae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D011374:Progesterone / Q000097:blood*; D011863:Radioimmunoassay; D019522:Vaginal Discharge / Q000382:microbiology; D055815:Young Adult
D000942:Antigens, Bacterial; D011374:Progesterone; D004958:Estradiol
Biol Reprod. 2007 Dec;77(6):1049-59
17881767
APMIS. 2007 Mar;115(3):231-41
17367469
Infect Immun. 1999 Aug;67(8):3937-46
10417159
Infect Immun. 2000 Jul;68(7):4207-16
10858238
Mol Microbiol. 2005 Mar;55(6):1704-21
15752195
Obstet Gynecol. 2002 Sep;100(3):579-84
12220782
Sex Transm Infect. 2001 Dec;77(6):398-401
11714934
Cytokine. 2002 Aug 21;19(4):193-200
12297113
Infect Immun. 2003 Oct;71(10):5576-82
14500476
Clin Microbiol Rev. 2004 Oct;17(4):965-81, table of contents
15489357
Sex Transm Infect. 2005 Oct;81(5):403-7
16199740
Antimicrob Agents Chemother. 1980 Aug;18(2):281-8
6778380
Sex Transm Dis. 2006 Jun;33(6):357-60
16572037
Lupus. 2004;13(9):635-8
15485092
Infect Immun. 2000 Feb;68(2):651-7
10639429
J Virol. 2003 Apr;77(8):4558-65
12663762
Int J Dermatol. 2009 Sep;48(9):1011-6
19702993
Sex Transm Dis. 2006 May;33(5):289-95
16554697
J Infect Dis. 2004 Apr 15;189(8):1497-505
15073688
Infect Immun. 1974 Dec;10(6):1370-7
4154922