title: Design and synthesis of selective and potent orally active S1P5 agonists.
authors.affiliation: Novartis Institute for Biomedical Research, Basel Switzerland. henri.mattes@novartis.com
authors.forename: Henri
authors.initials: H
authors.lastname: Mattes
authors.forename: Kumlesh Kumar
authors.initials: KK
authors.lastname: Dev
authors.forename: Rochdi
authors.initials: R
authors.lastname: Bouhelal
authors.forename: Carmen
authors.initials: C
authors.lastname: Barske
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gasparini
authors.forename: Danilo
authors.initials: D
authors.lastname: Guerini
authors.forename: Anis Khusro
authors.initials: AK
authors.lastname: Mir
authors.forename: David
authors.initials: D
authors.lastname: Orain
authors.forename: Maribel
authors.initials: M
authors.lastname: Osinde
authors.forename: Anne
authors.initials: A
authors.lastname: Picard
authors.forename: Celine
authors.initials: C
authors.lastname: Dubois
authors.forename: Engin
authors.initials: E
authors.lastname: Tasdelen
authors.forename: Samuel
authors.initials: S
authors.lastname: Haessig
mesh_terms: D000284:Administration, Oral; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D015195:Drug Design; D000068876:Fingolimod Hydrochloride; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000378:metabolism; D009836:Oligodendroglia / Q000187:drug effects / Q000378:metabolism; D010793:Phthalazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D011409:Propylene Glycols / Q000737:chemistry; D051381:Rats; D049349:Receptors, Lysosphingolipid / Q000819:agonists* / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D004676:Myelin Basic Protein; D010793:Phthalazines; D011409:Propylene Glycols; D049349:Receptors, Lysosphingolipid; C043388:phthalazine; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine