title: What is the evidence for total knee arthroplasty in young patients?: a systematic review of the literature.
abstract: BACKGROUND
  TKA is commonly performed to treat advanced inflammatory and degenerative knee arthritis. With increasing use in younger patients, it is important to define the best practices to enhance clinical performance and implant longevity.
  
  
  OBJECTIVE
  We systematically reviewed the literature to assess: (1) how TKAs perform in young patients; (2) whether the TKA is a durable procedure for young patients, and (3) what guidance the literature outlines for TKA in young patients.
  
  
  METHODS
  We searched the literature between 1950 and 2009 for all studies reporting on TKAs for patients younger than 55 years that documented clinical and radiographic assessments with a minimum 2-year followup. Thirteen studies, reporting on 908 TKAs performed for 671 patients, met these criteria.
  
  
  RESULTS
  Mean Knee Society clinical and functional scores increased by 47 and 37 points, respectively. Implant survivorship was reported between 90.6% and 99% during the first decade and between 85% and 96.5% during the second decade of followup. The literature does not direct specific techniques for TKA for young patients.
  
  
  CONCLUSIONS
  TKA provides surgeon-measured clinical and functional improvements with a moderate increase in second-decade implant failures. Improvements in study design and reporting will be beneficial to guide decisions regarding implant selection and surgical technique.
  
  
  METHODS
  Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Department of Orthopaedic Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8233, St Louis, MO 63110, USA. keeneyj@wudosis.wustl.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Keeney
authors.forename: Selena
authors.initials: S
authors.lastname: Eunice
authors.forename: Gail
authors.initials: G
authors.lastname: Pashos
authors.forename: Rick W
authors.initials: RW
authors.lastname: Wright
authors.forename: John C
authors.initials: JC
authors.lastname: Clohisy
mesh_terms: D000328:Adult; D000367:Age Factors; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000534:rehabilitation*; D016206:Databases, Bibliographic; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D011475:Prosthesis Failure / Q000209:etiology*; D011859:Radiography; D020127:Recovery of Function
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