[Effect of erythropoietin on blood oxygen transport in rats during cold exposure and subsequent rewarming].
Effect of erythropoietin (EPO) preparation (epocrine) on the blood oxygen transport in rats exposed to cold (120 min in a water-cooled box at 19 degrees C) and then rewarmed (next 120 min at a mean heating rate of 0.06 degrees C/min) has been studied. The administration of EPO reduced the body temperature fall at the end of cold exposure and enhanced its rise during the rewarming stage. The effect of EPO in tested rats is associated with a decrease in the hemoglobin affinity to oxygen, which increases the oxygen supply of tissues and improves the organism adaptability to cold.
Zinchuk
V V
VV
Glutkin
S V
SV
D000818:Animals; D001692:Biological Transport; D004921:Erythropoietin / Q000627:therapeutic use*; D007035:Hypothermia / Q000097:blood / Q000188:drug therapy*; D007036:Hypothermia, Induced; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D011994:Recombinant Proteins; D017694:Rewarming
D011994:Recombinant Proteins; D004921:Erythropoietin; D010100:Oxygen