title: Changes in serum TSH and free T4 during human sleep restriction.
abstract: OBJECTIVE
  To examine whether recurrent sleep restriction is accompanied by changes in measures of thyroid function.
  
  
  METHODS
  Two-period crossover intervention study.
  
  
  METHODS
  University clinical research center and sleep laboratory.
  
  
  METHODS
  11 healthy volunteers (5F/6M) with a mean (+/- SD) age of 39 +/- 5 y and BMI 26.5 +/- 1.5 kg/m2.
  
  
  METHODS
  Randomized exposure to 14 days of sedentary living with ad libitum food intake and 5.5- vs. 8.5-h overnight sleep opportunity.
  
  
  RESULTS
  Serum thyroid-stimulating hormone (TSH) and free thyroxine (T4) were measured at the end of each intervention. Partial sleep restriction was accompanied by a modest but statistically significant reduction in TSH and free T4, seen mainly in the female participants of the study.
  
  
  CONCLUSIONS
  Compared to the well-known rise in TSH and thyroid hormone concentrations during acute sleep loss, tests obtained after 14 days of partial sleep restriction did not show a similar activation of the human thyroid axis.
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Kessler
authors.forename: Arlet
authors.initials: A
authors.lastname: Nedeltcheva
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Imperial
authors.forename: Plamen D
authors.initials: PD
authors.lastname: Penev
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D012016:Reference Values; D012892:Sleep Deprivation / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
chemical_list: D013972:Thyrotropin; D013974:Thyroxine
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