title: [Vasoconstriction is required for edema of contralateral lung after reperfusion injury of one lung].
abstract: Ischemia-reperfusion (IR) lung injury is a significant cause of morbidity and mortality in certain clinical scenarios that include transplantation, thromboendarterectomy and reexpansion injury of the lung. Edema of the contralateral lung after IR injury of one lung has been reported and this study was aimed to clarify the pathophysiology of this phenomenon. One-lung ischemia/hypoxia followed by reperfusion with either blood or an acellular plasma substitute was achieved in an isolated rabbit lung model by hilum clamping. After reperfusion, we studied the isolated effects of vasoconstriction and inflammation on contralateral lung injury by using papaverine or hydrocortisone as vasodilator and anti-inflammatory, respectively. We observed that IR of one lung induces edema of the contralateral lung. Absence of leukocytes and platelets in the perfusate or use of hydrocortisone completely inhibits IR injury. Moreover, papaverine suppresses edema of the contralateral, but not that of the reperfused lung. We concluded that IR of one lung produces edema in the contralateral lung that requires vasoconstriction of the latter.
authors.affiliation: Sección de Fisiología Respiratoria, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Pezzulo
authors.forename: Ignacio
authors.initials: I
authors.lastname: Castro
authors.forename: Humberto
authors.initials: H
authors.lastname: Trejo
authors.forename: Daniela
authors.initials: D
authors.lastname: Urich
authors.forename: Juan
authors.initials: J
authors.lastname: Caraballo
authors.forename: Jeydith
authors.initials: J
authors.lastname: Gutiérrez
authors.forename: Camilo
authors.initials: C
authors.lastname: Cano
authors.forename: Roberto
authors.initials: R
authors.lastname: Sánchez de León
mesh_terms: D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply*; D011654:Pulmonary Edema / Q000209:etiology*; D011817:Rabbits; D015427:Reperfusion Injury / Q000150:complications* / Q000503:physiopathology*; D014661:Vasoconstriction