title: Anti-cancer effects of celecoxib on nasopharyngeal carcinoma HNE-1 cells expressing COX-2 oncoprotein.
abstract: Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor with antitumor and antiangiogenic activities. To investigate the effects of celecoxib on nasopharyngeal carcinoma (NPC), HNE-1 cells were treated with celecoxib at various concentrations. MTT assay, migration assay and invasion assay were performed to observe the inhibitory activity of celecoxib on HNE-1 cells. Additionally, VEGF-A expression and radiation survival of NPC cell were also examined after treatment with celecoxib. Celecoxib treatment presented an anti-proliferation function in a time and dose-dependent manner on HNE-1 cells which highly express COX-2 protein. Celecoxib also displayed an obvious inhibitory activity on invasive capacity of NPC cells. Moreover, the celecoxib's effects to suppress VEGF-A expression and enhance radiosensitivity were detected in HNE-1 cells. These findings implicate that application of celecoxib may be an effective strategy for NPC therapy.
authors.affiliation: Tumor Research Lab, Cancer Hospital of Shantou University Medical College, 515041, Shantou, People's Republic of China.
authors.forename: Jiongyu
authors.initials: J
authors.lastname: Chen
authors.forename: Yonggang
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authors.lastname: Ran
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Hong
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Chen
authors.forename: Yanjie
authors.initials: Y
authors.lastname: You
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