title: Renal allograft failure due to emphysematous pyelonephritis: successful non-operative management and proposed new classification scheme based on literature review.
abstract: Emphysematous pyelonephritis (EPN) is a rare necrotizing infection of the kidney caused by gas-forming organisms, usually occurs in diabetic patients, and often requires nephrectomy for effective therapy. EPN is rarely reported in renal allografts, with only 20 cases found in the English literature. We report herein a case of EPN in a transplanted kidney resulting in acute renal failure and sepsis. The patient was managed non-operatively with subsequent recovery of renal allograft function. Based on this experience and a review of the literature, we suggest an amended classification system for EPN in kidney transplantation to plan and guide treatment options accordingly. However, the scarcity of this disease process, coupled with the lack of prospective validation of the new classification scheme, prevents drawing definitive conclusions regarding optimal management strategies including the role and timing of allograft nephrectomy.
authors.affiliation: Department of General Surgery, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157, USA.
authors.forename: S M T
authors.initials: SM
authors.lastname: Al-Geizawi
authors.forename: A C
authors.initials: AC
authors.lastname: Farney
authors.forename: J
authors.initials: J
authors.lastname: Rogers
authors.forename: D
authors.initials: D
authors.lastname: Assimos
authors.forename: J A
authors.initials: JA
authors.lastname: Requarth
authors.forename: W
authors.initials: W
authors.lastname: Doares
authors.forename: S
authors.initials: S
authors.lastname: Winfrey
authors.forename: R J
authors.initials: RJ
authors.lastname: Stratta
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D004322:Drainage / Q000379:methods*; D004646:Emphysema / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011704:Pyelonephritis / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D015641:Radiography, Interventional / Q000379:methods*; D018805:Sepsis / Q000209:etiology; D015898:Tomography Scanners, X-Ray Computed; D016896:Treatment Outcome