Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation.
Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated membranoproliferative glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I membranoproliferative glomerulonephritis. Salivary gland biopsy demonstrated mild lymphocytic infiltration, indicating chronic GVHD. Improvement of the proteinuria and recovery of renal function were achieved within 11 months of treatment with oral prednisolone and azathioprine.
Kim
Ju Youn
JY
Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Republic of Korea.
Lee
Min Young
MY
Kim
Biro
B
Park
Cheol Whee
CW
Chang
Yoon Sik
YS
Chung
Sungjin
S
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006086:Graft vs Host Disease / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use
D011239:Prednisolone; D001379:Azathioprine
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