title: Fibrocystic disease of liver and pancreas; under-recognized features of the X-linked ciliopathy oral-facial-digital syndrome type 1 (OFD I).
abstract: OFD I is an X-linked dominant male-lethal ciliopathy characterized by prominent external features including oral clefts, hamartomas or cysts of the tongue, and digital anomalies. Although these external features are easy to recognize and often lead to diagnosis in early childhood, visceral findings in OFD I, especially the fibrocystic liver and pancreas disease, are under-recognized. In addition, while the occurrence of polycystic kidney disease (PKD) in OFD I is well known, few patients are evaluated and monitored for this complication. We report on two adult females diagnosed with OFD I in infancy, but not evaluated for visceral involvement. In adulthood, they were incidentally found to have severe hypertension and chronic renal insufficiency due to undiagnosed PKD. A pancreatic cystic lesion, also discovered incidentally, was thought to be malignant and led to consideration of major surgery. We present NIH evaluations, including documentation of OFD I mutations, extreme beading of the intrahepatic bile ducts, pancreatic cysts, and tabulate features of reported OFD I cases having hepatic, pancreatic, and renal cystic disease. Liver and pancreas are not routinely evaluated in OFD I patients. Increased awareness and lifelong monitoring of visceral complications, particularly involving the liver, pancreas, and kidney, are essential for timely and accurate treatment.
authors.affiliation: NIH-NHGRI, Medical Genetics Branch, Bethesda, Maryland 20892, USA.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Chetty-John
authors.forename: Katie
authors.initials: K
authors.lastname: Piwnica-Worms
authors.forename: Joy
authors.initials: J
authors.lastname: Bryant
authors.forename: Isa
authors.initials: I
authors.lastname: Bernardini
authors.forename: Roxanne E
authors.initials: RE
authors.lastname: Fischer
authors.forename: Theo
authors.initials: T
authors.lastname: Heller
authors.forename: William A
authors.initials: WA
authors.lastname: Gahl
authors.forename: Meral
authors.initials: M
authors.lastname: Gunay-Aygun
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D017384:Sequence Deletion; D014059:Tongue / Q000002:abnormalities
chemical_list: C115130:OFD1 protein, human; D011506:Proteins
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