title: Internal target volume defined by contrast-enhanced 4D-CT scan in unresectable pancreatic tumour: evaluation and reproducibility.
abstract: We compared customized ITVs obtained with CE-4D-CT imaging (ITV(4D)) with a population-based (ITV(PBC)) in 29 patients (PTs) and evaluated the intra-observer ITV delineation reproducibility in 5 PTs with unresectable pancreatic ductal adenocarcinoma (PDA). The ITV(PBC) was quite different from the ITV(4D), with under/over estimation of volume. Intra-observer volume delineation variability on CE-4D-CT and on a single-phase CE-CT were similar (27.6% vs 24.9%).
authors.affiliation: Medical Physics Department, San Raffaele Scientific Institute, Milano, Italy. mauro.cattaneo@hsr.it
authors.forename: Giovanni Mauro
authors.initials: GM
authors.lastname: Cattaneo
authors.forename: Paolo
authors.initials: P
authors.lastname: Passoni
authors.forename: Giulia
authors.initials: G
authors.lastname: Sangalli
authors.forename: Najla
authors.initials: N
authors.lastname: Slim
authors.forename: Barbara
authors.initials: B
authors.lastname: Longobardi
authors.forename: Pietro
authors.initials: P
authors.lastname: Mancosu
authors.forename: Valentino
authors.initials: V
authors.lastname: Bettinardi
authors.forename: Nadia
authors.initials: N
authors.lastname: Di Muzio
authors.forename: Riccardo
authors.initials: R
authors.lastname: Calandrino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D003287:Contrast Media; D005260:Female; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted; D015203:Reproducibility of Results; D012119:Respiration; D014283:Triiodobenzoic Acids; D047368:Tumor Burden
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol