Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy.
Unique advantages offered by nuclear magnetic resonance (NMR) spectroscopy provide high-resolution information not only on structures but also on dynamics and interactions of glycoconjugates in solution. These benefits are further enhanced by applying stable-isotope-labeling techniques, which we have developed. Our stable-isotope-assisted NMR analyses of immunoglobulin G-Fc glycoproteins and the glycopeptides derived therefrom are here presented in terms of the dynamics and interactions of glycoconjugates.
Yamaguchi
Yoshiki
Y
Systems Glycobiology Research Group, Chemical Biology Department, RIKEN, Advanced Science Institute, Hirosawa, Wako, Japan.
Kato
Koichi
K
D002240:Carbohydrate Sequence; D006001:Glycoconjugates / Q000737:chemistry*; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods*; D037102:Lectins / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012996:Solutions / Q000737:chemistry
D006001:Glycoconjugates; D007074:Immunoglobulin G; D037102:Lectins; D008024:Ligands; D012996:Solutions