[An investigation of Gram-positive bacteria infection in an intensive care unit during 6 years].
OBJECTIVE
To retrospectively investigate the risk factors, distribution, antibiotic resistance of infection with Gram-positive (G+) bacteria in an intensive care unit (ICU), so as to provide the reference for clinical prevention and treatment.


METHODS
A retrospective analysis of clinical data of 83 patients with G+ bacteria infection in ICU from January 2003 to December 2008 was done.


RESULTS
Of the 125 strains of G+ bacteria from 83 patients, Staphylococcus was the main organism (63.2%, 79/125). The prognosis of the patient was related with surgical operation (chi2=9.107, P=0.003), gastric intubation (chi2=4.053, P=0.044), complication (chi2 5.908, P=0.015) and the use of immunosuppressant (chi2=5.761, P=0.016). Multi-bacterial infection was related with surgery (chi2=8.847, P=0.003) and tracheostomy (chi2=10.445, P=0.001). The antibiotic susceptibility test in vitro showed that G+ bacteria displayed multi-resistance to antibiotics, but all of G+ bacteria were sensitive to vancomycin (resistance rate was 0).


CONCLUSIONS
Staphylococcus was the most common pathogen of G+ bacterial infection in ICU. Further surveillance of bacterial resistance is warranted in ICU, and antimicrobial drugs should be used according to the result of susceptibility test. Taking account of the antibiotic resistance and risk factors of G+ bacteria infection in ICU, the infection could be controlled and the death rate could be cut down when appropriate measures are taken.
Wang
Min
M
Department of Infectious Disease, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China.
Sun
Jing
J
Shi
Wei
W
Ma
Tai
T
Cheng
Jun
J
Luo
Xiao-ming
XM
Wang
Zhong-xin
ZX
Ye
Ying
Y
Li
Jia-bin
JB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D024881:Drug Resistance, Bacterial; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D055815:Young Adult