title: Should mood during intravenous alcohol administration be studied as a bi- or unipolar phenomenon? a pilot study.
abstract: In this study, alcohol was administered intravenously to study whether its effects on mood should preferably be studied as a bi- or unipolar phenomenon. This was studied in a double-blind, placebo-balanced, design on six healthy male volunteers. Of the three bipolar aspects of mood (calmness, activity, and pleasantness), only calmness was significantly affected by intravenous alcohol. In contrast, there were significant differences between alcohol and placebo for five of the six unipolar indexes. This support the hypothesis that subjective effects of alcohol on mood are preferably studied with self-ratings that allows positive and negative aspects to be analyzed separately. Further, our data suggest that the effects of alcohol are primarily on negative aspects of mood rather than on positive.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Saxon
authors.forename: Stefan
authors.initials: S
authors.lastname: Skagerberg
authors.forename: Stefan
authors.initials: S
authors.lastname: Borg
authors.forename: Arto J
authors.initials: AJ
authors.lastname: Hiltunen
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D003866:Depressive Disorder / Q000139:chemically induced*; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010865:Pilot Projects; D010919:Placebos
chemical_list: D010919:Placebos; D000431:Ethanol