[Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis].
OBJECTIVE
To investigate the effect of sinomenine on the level of tumor necrosis factor-alpha (TNF-alpha) and nuclear factor-kappaB (NF-kappaB) and in the heterotopic tissue in rats with endometriosis.


METHODS
The rats with endometriosis were divided into sinomenine lavage group, blank control group, model group and danazol group, and the levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats were detected with immunohistochemistry.


RESULTS
Sinomenine lavage and danazol treatment both significantly decreased the levels of levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats as compared with the model group (P<0.05), and lesions were significantly smaller in sinomenine lavage group than in danazol group.


CONCLUSIONS
Sinomenine can inhibit the production and activity of TNF-alpha and NF-kappaB to suppress the adhesion, implantation, infiltration and growth of the endometrial cells in the rat model of endometriosis.
Yi
Hua
H
Basic Medical School, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. yihuayi-027@163.com
Lu
Yue
Y
Chen
Jian-kun
JK
Du
Biao-yan
BY
Liu
Ai-jun
AJ
Luo
Hui
H
D000818:Animals; D002828:Choristoma / Q000378:metabolism*; D003613:Danazol / Q000494:pharmacology; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D009019:Morphinans / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D009019:Morphinans; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C009271:sinomenine; D003613:Danazol