title: Evaluation of predictive models for stable solid solution formation.
abstract: The objective of this study was to evaluate predictive models for stable solid solution formation and to find a quick and successful approach for miscibility screenings. The results show that the interpretation of the chemical structure and the crystallinity by X-ray powder diffraction measurements as well as the determination of melting point depressions and melting enthalpies are beneficial tools to predict the miscibility of drugs and carriers. A combined approach of prediction tools is highly appropriate, as no single technique may yield all the required information. Nevertheless, the evaluation of the melting behavior via differential scanning calorimetry has the highest impact.
authors.affiliation: Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany.
authors.forename: Jessica
authors.initials: J
authors.lastname: Albers
authors.forename: Karin
authors.initials: K
authors.lastname: Matthée
authors.forename: Klaus
authors.initials: K
authors.lastname: Knop
authors.forename: Peter
authors.initials: P
authors.lastname: Kleinebudde
mesh_terms: D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D044367:Phase Transition; D012995:Solubility; D012996:Solutions / Q000737:chemistry; D013816:Thermodynamics; D044366:Transition Temperature
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012996:Solutions