Botox transient treatment of tinnitus due to stapedius myoclonus: case report.
OBJECTIVE
To explore the feasibility of using botulinum toxin type A (BTXA) to treat tinnitus due to stapedius myoclonus.


METHODS
A piece of gelfoam containing BTXA (25 U/ml) was placed, through a perforation in tympanic membrane, into the middle ear cavity of a patient suffering from tinnitus due to stapedius myoclonus.


RESULTS
The tinnitus disappeared on the second day after the BTXA treatment. The patient was free of symptoms during a 3-month follow-up period. Tinnitus reappeared at 4 months, and disappeared after second BTXA local treatment.


CONCLUSIONS
Local BTXA treatment may be considered as a treatment for tinnitus caused by stapedius myoclonus.
Liu
Hai-Bin
HB
Department of Otolaryngology-Head & Neck Surgery, ChangZheng Hospital, Second Military Medical University, Fengyang Road 415, Huangpu District, Shanghai, China.
Fan
Jing-Ping
JP
Lin
Shun-Zhang
SZ
Zhao
Shu-Wei
SW
Lin
Zheng
Z
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009207:Myoclonus / Q000150:complications*; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013198:Stapedius; D014012:Tinnitus / Q000188:drug therapy* / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D018058:Tympanic Membrane Perforation
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A