title: Sucralose sweetener in vivo effects on blood constituents radiolabeling, red blood cell morphology and radiopharmaceutical biodistribution in rats.
abstract: Effects of sucralose sweetener on blood constituents labelled with technetium-99m ((99m)Tc) on red blood cell (RBC) morphology, sodium pertechnetate (Na(99m)TcO(4)) and diethylenetriaminepentaacetic acid labeled with (99m)Tc ((99m)Tc-DTPA) biodistribution in rats were evaluated. Radiolabeling on blood constituents from Wistar rats was undertaken for determining the activity percentage (%ATI) on blood constituents. RBC morphology was also evaluated. Na(99m)TcO(4) and (99m)Tc-DTPA biodistribution was used to determine %ATI/g in organs. There was no alteration on RBC blood constituents and morphology %ATI. Sucralose sweetener was capable of altering %ATI/g of the radiopharmaceuticals in different organs. These findings are associated to the sucralose sweetener in specific organs.
authors.affiliation: Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofísica e Biometria, Avenida 28 de Setembro, 87, Vila Isabel, 20551030 Rio de Janeiro, Brazil.
authors.forename: G S
authors.initials: GS
authors.lastname: Rocha
authors.forename: M O
authors.initials: MO
authors.lastname: Pereira
authors.forename: M O
authors.initials: MO
authors.lastname: Benarroz
authors.forename: J N G
authors.initials: JN
authors.lastname: Frydman
authors.forename: V C
authors.initials: VC
authors.lastname: Rocha
authors.forename: M J
authors.initials: MJ
authors.lastname: Pereira
authors.forename: A S
authors.initials: AS
authors.lastname: Fonseca
authors.forename: A C
authors.initials: AC
authors.lastname: Medeiros
authors.forename: M
authors.initials: M
authors.lastname: Bernardo-Filho
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000097:blood* / Q000494:pharmacology; D013395:Sucrose / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D013549:Sweetening Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D016284:Technetium Tc 99m Pentetate / Q000097:blood* / Q000494:pharmacology; D014018:Tissue Distribution
chemical_list: D013549:Sweetening Agents; D013395:Sucrose; C026285:trichlorosucrose; D013670:Sodium Pertechnetate Tc 99m; D016284:Technetium Tc 99m Pentetate