title: Application of an artificial neural network to the computer-aided differentiation of focal liver disease in MR imaging.
abstract: The differentiation of focal liver lesions in magnetic resonance (MR) imaging is primarily based on the intensity and homogeneity of lesions with different imaging sequences. However, these imaging findings are falsely interpreted in some patients because of the complexities involved. Our aim is to establish a computer-aided diagnosis system named LiverANN for classifying the pathologies of focal liver lesions into five categories using the artificial neural network (ANN) technique. On each MR image, a region of interest (ROI) in the focal liver lesion was delineated by a radiologist. The intensity and homogeneity within the ROI were calculated automatically, producing numerical data that were analyzed by feeding them into the LiverANN as inputs. Outputs were the following five pathologic categories of hepatic disease: hepatic cyst, hepatocellular carcinoma, dysplasia in cirrhosis, cavernous hemangioma, and metastasis. Of the 320 MR images obtained from 80 patients (four images per patient) with liver lesions, our LiverANN classified 50 cases of a training set into five types of liver lesions with a training accuracy of 100% and 30 test cases with a testing accuracy of 93%. The experiment demonstrated that our LiverANN, which functions as a computer-aided differentiation tool, can provide radiologists with a second opinion during the radiologic diagnostic procedure.
authors.affiliation: Department of Electronics and Information Engineering, School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, People's Republic of China. xjzhang@gxu.edu.cn
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanematsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Zhou
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hara
authors.forename: Ryujiro
authors.initials: R
authors.lastname: Yokoyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hoshi
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D016571:Neural Networks, Computer
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