Fragile privileges: autoimmunity in brain and eye.
Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reactivity in the healthy eye and brain tissues, and mechanisms that can overcome the protective barriers to create tissue specific disease.
Wekerle
Hartmut
H
Max-Planck-Institute of Neurobiology, Martinsried, Germany. hwekerle@neuro.mpg.de
Sun
De-ming
DM
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000473:pathology; D005123:Eye / Q000276:immunology* / Q000473:pathology; D006801:Humans
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