Cellular responses to Cisplatin-induced DNA damage.
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis. How cells respond to cisplatin-induced DNA damage plays a critical role in deciding cisplatin sensitivity. Cisplatin-induced DNA damage activates various signaling pathways to prevent or promote cell death. This paper summarizes our current understandings regarding the mechanisms by which cisplatin induces cell death and the bases of cisplatin resistance. We have discussed various steps, including the entry of cisplatin inside cells, DNA repair, drug detoxification, DNA damage response, and regulation of cisplatin-induced apoptosis by protein kinases. An understanding of how various signaling pathways regulate cisplatin-induced cell death should aid in the development of more effective therapeutic strategies for the treatment of cancer.
Basu
Alakananda
A
Department of Molecular Biology & Immunology, University of North Texas Health Science Center and Institute for Cancer Research, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Krishnamurthy
Soumya
S
Anticancer Drug Des. 1998 Jan;13(1):35-45
9474241
J Biol Chem. 1990 Aug 5;265(22):13137-42
2376590
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14298-302
12370430
Cancer Res. 2000 Nov 1;60(21):5988-94
11085518
Gynecol Oncol. 2004 Apr;93(1):144-8
15047228
Anticancer Agents Med Chem. 2007 Jan;7(1):3-18
17266502
J Biol Chem. 1990 May 25;265(15):8451-7
2341390
Cancer Res. 1991 May 15;51(10):2511-4
2021930
Chembiochem. 2005 Jul;6(7):1157-66
15934047
Cancer Res. 1996 Aug 1;56(15):3577-82
8758929
J Inorg Biochem. 2004 Oct;98(10):1607-13
15458823
J Biol Chem. 2000 Nov 17;275(46):35778-85
10958792
Int J Cancer. 1993 Sep 30;55(3):521-7
8375936
Oncogene. 2000 Jun 29;19(28):3138-45
10918568
Mol Cancer Ther. 2008 Oct;7(10):3247-55
18852128
Nephrol Dial Transplant. 2007 Aug;22(8):2138-48
17438009
Anticancer Drugs. 2006 Jan;17(1):41-51
16317289
Cancer Res. 2006 May 1;66(9):4627-35
16651413
Cell Death Differ. 2001 Sep;8(9):899-908
11526445
J Biol Chem. 2003 May 23;278(21):19245-56
12637505
Oncogene. 2006 May 11;25(20):2909-19
16331246
Cancer Res. 2008 Jan 15;68(2):425-33
18199536
EMBO J. 1995 Nov 15;14(22):5579-88
8521815
Biochem J. 2003 Mar 1;370(Pt 2):361-71
12495431
Mol Pharmacol. 2006 Oct;70(4):1390-4
16847145
Cancer. 1994 Apr 15;73(8):2013-26
8156506
Cell Cycle. 2008 May 15;7(10):1353-9
18418074
Cancer Res. 1996 Feb 1;56(3):556-62
8564971
Hear Res. 2008 May;239(1-2):79-91
18329831
Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10144-9
9294177
Br J Pharmacol. 2009 Mar;156(5):751-63
19254279
Toxicol Lett. 1990 Feb;50(2-3):123-35; discussion 121-2
2408195
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2420-5
12601175
Int J Cancer. 2005 Dec 10;117(5):755-63
15981204
Cancer Res. 2004 Jan 15;64(2):517-22
14744764
Mol Cancer Ther. 2002 Aug;1(10):861-7
12492119
Cancer Lett. 2008 Jul 8;265(2):188-96
18353540
Biochem Biophys Res Commun. 2004 Apr 16;316(4):1002-8
15044084
J Biol Chem. 1990 Mar 5;265(7):3623-7
2303468
Curr Med Chem. 2008;15(26):2656-63
18991628
Clin Cancer Res. 2004 Oct 1;10(19):6744-9
15475465
J Biol Chem. 2002 Nov 8;277(45):43377-88
12218054
Int J Cancer. 2010 Dec 15;127(12):2790-803
21351258
Nat Struct Mol Biol. 2007 Dec;14(12):1127-33
17994106
Int J Cancer. 2004 Jun 20;110(3):352-61
15095299
Trends Biochem Sci. 2001 Nov;26(11):657-64
11701324
Cancer Res. 2003 Nov 1;63(21):7081-8
14612499
Trends Biochem Sci. 1995 Oct;20(10):435-9
8533159
Eur J Cancer. 1998 Oct;34(11):1802-6
9893672
Cancer Res. 2007 Jul 1;67(13):6325-32
17616691
Pharmacol Ther. 1993 Sep;59(3):257-80
8309991
Int J Cancer. 2008 Jan 15;122(2):289-97
17893873
Oncogene. 1998 Nov 5;17(18):2339-50
9811465
Curr Opin Mol Ther. 1999 Aug;1(4):500-9
11713766
Int J Oncol. 2007 Feb;30(2):403-11
17203222
Int J Oncol. 2005 Jul;27(1):149-54
15942654
Oncogene. 2006 Nov 30;25(56):7381-90
16785992
Nature. 1995 Aug 31;376(6543):785-8
7651539
Cancer Chemother Pharmacol. 1987;19(2):149-54
3568272
Cancer Res. 2006 Mar 15;66(6):3126-36
16540663
J Biol Chem. 2009 May 22;284(21):14029-39
19286655
J Exp Med. 1996 Dec 1;184(6):2399-404
8976194
Science. 1985 Oct 25;230(4724):412-7
4048939
Cancer Res. 2004 May 15;64(10):3391-4
15150090
Oncogene. 2006 Jul 6;25(29):4056-66
16491117
Br J Cancer. 1999 Mar;79(7-8):1104-10
10098743
Science. 2002 Dec 6;298(5600):1911-2
12471242
Cell Death Differ. 2008 Mar;15(3):530-44
18064040
Semin Oncol. 2003 Aug;30(4 Suppl 10):26-31
12917818
Hum Cell. 2001 Sep;14(3):165-71
11774736
Mutat Res. 2001 Jul 1;478(1-2):1-21
11406166
J Biol Chem. 2000 Dec 15;275(50):39435-43
10993883
Cancer. 1985 May 15;55(10):2303-l6
3886121
Apoptosis. 2008 Feb;13(2):259-71
18071906
Neurotoxicology. 2004 Dec;25(6):915-24
15474610
Biochem Biophys Res Commun. 1990 Feb 14;166(3):1358-64
2306248
Curr Biol. 1999 Mar 11;9(5):273-6
10074455
Biochem J. 2007 Aug 1;405(3):617-23
17521288
J Toxicol Sci. 2007 Aug;32(3):321-8
17785947
Pharmacol Ther. 1987;34(2):155-66
3317449
Drug Metab Dispos. 2003 Jul;31(7):916-23
12814969
J Mol Biol. 2007 May 25;369(1):27-40
17400248
Int J Oncol. 2008 May;32(5):1133-7
18425342
EMBO J. 2007 Apr 18;26(8):2115-26
17380123
Gynecol Oncol. 2006 Aug;102(2):348-55
16545436
Int J Cancer. 2008 May 15;122(10):2380-4
18224693
Clin Cancer Res. 1999 May;5(5):1007-14
10353733
Histopathology. 2004 Aug;45(2):103-18
15279628
Cancer Res. 2004 Jan 1;64(1):356-62
14729645
Mol Pharmacol. 2010 Jun;77(6):887-94
20159940
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10281-6
12928501
Oncogene. 1996 Sep 19;13(6):1279-85
8808702
Br J Cancer. 1993 Jun;67(6):1171-6
8512802
Curr Biol. 1996 May 1;6(5):606-13
8805279
Cancer Cell. 2004 Aug;6(2):139-50
15324697
Cell Cycle. 2007 May 2;6(9):1006-10
17457049
Mol Cancer Ther. 2006 May;5(5):1239-47
16731756
Carcinogenesis. 2010 May;31(5):804-11
20106899
Mol Pharmacol. 2008 Sep;74(3):697-704
18523133
Cancer Res. 1991 Jul 15;51(14):3677-81
1648442
J Biol Chem. 1993 Sep 25;268(27):20116-25
8376370
J Biol Chem. 2004 Oct 22;279(43):44713-22
15302867
Cancer Cells. 1990 Aug-Sep;2(8-9):275-80
2223389
Cancer Control. 2003 Jul-Aug;10(4):297-305
12915808
Neoplasia. 2010 Feb;12(2):128-38
20126471
Cancer Chemother Pharmacol. 1997;41(1):61-8
9443615
J Biol Chem. 1997 May 30;272(22):14041-4
9162025
Biochem Biophys Res Commun. 2005 Sep 9;334(4):1068-73
16039614
Mol Cell Biol. 2000 Jul;20(14):4979-89
10866655
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3070-4
1348364
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7957-61
19383798
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6163-8
9600935
Mutagenesis. 2008 Jan;23(1):43-50
18003626
Int J Cancer. 1995 Nov 15;63(4):597-603
7591272
J Biol Inorg Chem. 2009 Sep;14(7):1129-38
19536566
Carcinogenesis. 2009 Sep;30(9):1517-27
19578044
Nature. 1999 Jun 24;399(6738):806-9
10391249
Carcinogenesis. 2009 Aug;30(8):1298-304
19443905
Mutat Res. 2001 Jul 1;478(1-2):23-43
11406167
Cancer Res. 1997 Aug 1;57(15):3253-7
9242457
Endocrinology. 2006 Apr;147(4):1761-9
16396982
Metallomics. 2009;1(4):280-91
20046924
J Am Soc Nephrol. 2008 May;19(5):923-32
18256356
Biochem Pharmacol. 2002 Apr 15;63(8):1423-30
11996883
Int J Cancer. 1993 Oct 21;55(4):678-84
8406999
J Biol Chem. 1999 Oct 29;274(44):31648-54
10531373
Cancer Res. 1992 Jun 1;52(11):3119-24
1591725
Cancer Biol Ther. 2009 Feb;8(3):245-52
19106640
Science. 1988 Sep 30;241(4874):1813-5
3175622
Cell. 1995 Jan 27;80(2):179-85
7834738
Cancer Res. 2001 Feb 15;61(4):1508-16
11245458
Cell Death Differ. 2004 Mar;11(3):290-300
14657961
DNA Repair (Amst). 2010 Jul 1;9(7):745-53
20418188
Pathobiology. 2005;72(3):152-9
15860933
J Clin Invest. 2007 May;117(5):1370-80
17446929
Lung Cancer. 2008 Oct;62(1):8-14
18372076
Nature. 2001 Mar 1;410(6824):37-40
11242034
Oncogene. 2003 Jun 26;22(26):3998-4006
12821934
Biochemistry. 1999 Apr 6;38(14):4245-51
10194341
J Biol Chem. 2008 Mar 7;283(10):6572-83
18162465
Cancer Res. 2003 Jun 15;63(12):3418-24
12810679
Kidney Int. 2005 Feb;67(2):458-66
15673293
Biochem Biophys Res Commun. 2007 Aug 17;360(1):263-8
17586463
Biochem Biophys Res Commun. 2008 May 16;369(4):1098-102
18331824
Brain Res Mol Brain Res. 2001 Sep 10;93(1):18-26
11532334
Clin Cancer Res. 2007 May 15;13(10):2855-64
17504983
Biochim Biophys Acta. 2006 Jan;1763(1):93-100
16473140
Nature. 1965 Feb 13;205:698-9
14287410
Anticancer Drugs. 2009 Mar;20(3):208-14
19396019
J Med Chem. 2009 Jul 23;52(14):4319-28
19537717
Gynecol Oncol. 2004 Sep;94(3):785-95
15350374
Cancer Res. 2001 Mar 1;61(5):1862-8
11280739
Exp Cell Res. 1995 May;218(1):201-12
7537690
Cell Signal. 2007 Aug;19(8):1633-42
17537614
Nucleic Acids Res. 1997 Feb 1;25(3):491-6
9016586
Int J Cancer. 1995 Aug 9;62(4):457-60
7635571
Cancer Res. 2008 Mar 15;68(6):1916-26
18339873
Nat Med. 2009 Oct;15(10):1179-85
19783996
Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5874-9
14676109
Nat Rev Cancer. 2007 Aug;7(8):573-84
17625587
Cancer Res. 1996 Jul 1;56(13):3087-90
8674066
DNA Cell Biol. 2009 Jun;28(6):285-94
19317621
J Biol Chem. 2008 Feb 15;283(7):3731-42
18079115
J Biol Chem. 2004 Jun 18;279(25):26143-8
15073167
Cancer Invest. 2009 Nov;27(9):891-7
19832035
Cancer Res. 1995 Apr 15;55(8):1649-54
7712469
Nat Rev Drug Discov. 2005 Apr;4(4):307-20
15789122
Chem Rev. 1999 Sep 8;99(9):2467-98
11749487
J Biol Chem. 2003 Jun 27;278(26):23432-40
12697749
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4247-52
18337503
Biochim Biophys Acta. 2005 Apr 15;1743(3):269-79
15843040
Biochim Biophys Acta. 2001 Feb 16;1517(3):392-7
11342217
Nature. 1981 Nov 19;294(5838):281-3
6975441
Gynecol Oncol. 2007 Feb;104(2):338-44
17023032
Free Radic Biol Med. 2009 Jun 15;46(12):1607-13
19328230
Cancer Res. 1996 Feb 15;56(4):689-93
8630996
Biochem Pharmacol. 2010 Mar 15;79(6):810-6
19874802
Science. 2007 Nov 9;318(5852):967-70
17991862
Cancer Biol Ther. 2007 Feb;6(2):178-84
17218783
Oncogene. 1998 Jan 29;16(4):533-40
9484843
Cell Death Differ. 2007 Jun;14(6):1139-48
17363963
Mutat Res. 2003 Dec 10;533(1-2):201-9
14643421
Brain Res Bull. 2001 May 15;55(2):133-45
11470309
Int J Cancer. 1988 Sep 15;42(3):382-8
3417367
J Biol Chem. 2006 Sep 15;281(37):27117-25
16849332
Cancer Res. 1994 May 1;54(9):2287-91
8162565
Clin Cancer Res. 2005 Sep 15;11(18):6730-7
16166454
J Biol Chem. 1994 Jan 14;269(2):787-90
8288625
Am J Physiol Renal Physiol. 2005 Jul;289(1):F166-74
15701814
Nature. 1969 Apr 26;222(5191):385-6
5782119
J Biol Chem. 2010 Feb 5;285(6):3705-3712
19940136
Mol Med. 2010 Sep-Oct;16(9-10):409-16
20386864
Cancer Chemother Pharmacol. 2002 Nov;50(5):397-404
12439598
Curr Med Chem Anticancer Agents. 2005 May;5(3):251-65
15992353
J Biol Chem. 2003 Jun 6;278(23):21267-75
12654906
Br J Cancer. 2009 Jul 21;101(2):269-77
19603033
Oncogene. 2001 Oct 11;20(46):6805-8
11709715
Clin Cancer Res. 2009 Jul 1;15(13):4312-21
19509135
Oncogene. 1998 Dec 24;17(25):3237-45
9916986
Mol Cell. 2008 Feb 15;29(3):350-61
18280240
Arch Pharm (Weinheim). 2004 Dec;337(12):668-71
15614830
Cancer Chemother Pharmacol. 2009 Sep;64(4):803-10
19221754
Crit Rev Oncol Hematol. 2005 Jan;53(1):13-23
15607932
Cell Signal. 2009 Jul;21(7):1085-99
19258036
Clin Cancer Res. 2009 Jul 15;15(14):4538-45
19584164
Science. 1992 Oct 23;258(5082):607-14
1411571
Annu Rev Pharmacol Toxicol. 2008;48:495-535
17937596
Br J Cancer. 2004 Aug 2;91(3):589-98
15266324
Oncogene. 2010 Jan 7;29(1):11-25
19802016
Ann N Y Acad Sci. 2000;926:90-100
11193045
Cancer Res. 2008 Aug 15;68(16):6661-8
18701490
Cancer Res. 2008 Apr 15;68(8):2795-802
18413747
Oncol Res. 1999;11(3):153-9
10527075
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4890-5
20304803
Oncogene. 1997 Jul 3;15(1):45-52
9233776
J Cell Biochem. 2010 Jan 1;109(1):152-61
19911375
Melanoma Res. 2001 Feb;11(1):11-9
11254111
Gynecol Oncol. 2002 Feb;84(2):210-5
11812076
Life Sci. 2009 Apr 24;84(17-18):590-7
19302802
Virchows Arch. 2007 Mar;450(3):279-85
17235562
Cancer Chemother Pharmacol. 2001 Nov;48(5):383-8
11761456
Int J Cancer. 2010 Apr 15;126(8):1944-1954
19626585
J Appl Toxicol. 2005 Sep-Oct;25(5):374-82
16013042
Cancer Res. 2008 Jun 15;68(12):4511-7
18559494
J Biol Chem. 2004 Feb 13;279(7):5405-12
14645242