Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.
BACKGROUND
Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification.


METHODS
Horizon 1 of the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Study was conceived to apply emerging molecular techniques to existing data sets to characterize mechanistic diversity underlying complex human diseases, response to therapy, and prognosis. No previous studies have applied multiple, complementary molecular techniques in combination with well-developed clinical risk models to refine cardiovascular risk prediction. The MURDOCK Cardiovascular Disease Study will assess molecular profiles integrated with clinical data in "clinomic" profiles for cardiovascular risk classification.


CONCLUSIONS
Herein, we describe the design of and rationale for the MURDOCK Cardiovascular Disease Study.
Shah
Svati H
SH
Duke University Medical Center, Durham, NC, USA.
Granger
Christopher B
CB
Hauser
Elizabeth R
ER
Kraus
William E
WE
Sun
Jie-Lena
JL
Pieper
Karen
K
Nelson
Charlotte L
CL
Delong
Elizabeth R
ER
Califf
Robert M
RM
Newby
L Kristin
LK
D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D009657:North Carolina; D018579:Patient Selection; D057285:Precision Medicine; D016016:Proportional Hazards Models; D012107:Research Design; D018570:Risk Assessment / Q000145:classification*