title: Two cases with pulmonary mucosa-associated lymphoid tissue lymphoma successfully treated with clarithromycin.
abstract: A 70-year-old woman with a history of sinobronchial syndrome was admitted to the hospital because of a cough, sputum, and abnormal chest shadow. She was diagnosed with pulmonary mucosa-associated lymphoid tissue lymphoma (p-MALToma) based on results of a pathologic examination and the gene rearrangements in the Ig heavy chain on Southern blot hybridization. Although p-MALToma did not regress with conventional therapy, it was reduced after long-term treatment with clarithromycin (CAM) (200 mg/d). A 57-year-old woman with a history of Sjögren syndrome and lymphocytic interstitial pneumonia had a mass lesion in the left lower lung field. CT image-guided biopsy established a diagnosis of p-MALToma. The p-MALToma regressed with long-term treatment with CAM (200 mg/d), whereas Helicobacter pylori (HP) eradication therapy was not effective in concurrent atrophic gastritis with HP. It is suggested that CAM, a macrolide antibiotic, may be effective in some patients with p-MALToma.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Harada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hara
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hara
authors.forename: Misato
authors.initials: M
authors.lastname: Amenomori
authors.forename: Hanako
authors.initials: H
authors.lastname: Fujita
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D020545:Respiratory Mucosa
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin