title: The RAV1 transcription factor positively regulates leaf senescence in Arabidopsis.
abstract: Leaf senescence is a developmentally programmed cell death process that constitutes the final step of leaf development and involves the extensive reprogramming of gene expression. Despite the importance of senescence in plants, the underlying regulatory mechanisms are not well understood. This study reports the isolation and functional analysis of RAV1, which encodes a RAV family transcription factor. Expression of RAV1 and its homologues is closely associated with leaf maturation and senescence. RAV1 mRNA increased at a later stage of leaf maturation and reached a maximal level early in senescence, but decreased again during late senescence. This profile indicates that RAV1 could play an important regulatory role in the early events of leaf senescence. Furthermore, constitutive and inducible overexpression of RAV1 caused premature leaf senescence. These data strongly suggest that RAV1 is sufficient to cause leaf senescence and it functions as a positive regulator in this process.
authors.affiliation: Department of Biology, Chungnam National University, Daejeon, 305-764, Korea.
authors.forename: Hye Ryun
authors.initials: HR
authors.lastname: Woo
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Junyoung
authors.initials: J
authors.lastname: Kim
authors.forename: Jeongsik
authors.initials: J
authors.lastname: Kim
authors.forename: Ung
authors.initials: U
authors.lastname: Lee
authors.forename: In-Ja
authors.initials: IJ
authors.lastname: Song
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyo-Yeon
authors.initials: HY
authors.lastname: Lee
authors.forename: Hong Gil
authors.initials: HG
authors.lastname: Nam
authors.forename: Pyung Ok
authors.initials: PO
authors.lastname: Lim
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D008969:Molecular Sequence Data; D018515:Plant Leaves / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C117695:RAV1 protein, Arabidopsis; D014157:Transcription Factors
references.citation: Plant Cell. 2002 Mar;14(3):559-74
references.pmid: 11910004
references.citation: Curr Opin Plant Biol. 2004 Oct;7(5):491-8
references.pmid: 15337090
references.citation: Plant Physiol. 2000 Nov;124(3):1305-14
references.pmid: 11080306
references.citation: Curr Biol. 2008 Sep 9;18(17):1338-43
references.pmid: 18718758
references.citation: Plant Mol Biol. 2006 Aug;61(6):897-915
references.pmid: 16927203
references.citation: Planta. 2001 Jul;213(3):469-73
references.pmid: 11506370
references.citation: Plant Physiol. 2002 Mar;128(3):876-84
references.pmid: 11891244
references.citation: Genome Biol. 2004;5(4):R24
references.pmid: 15059257
references.citation: Science. 2009 Feb 20;323(5917):1053-7
references.pmid: 19229035
references.citation: Plant Cell. 2001 Aug;13(8):1779-90
references.pmid: 11487692
references.citation: Plant J. 1997 Sep;12(3):527-35
references.pmid: 9351240
references.citation: Trends Plant Sci. 2000 Jul;5(7):278-82
references.pmid: 10871899
references.citation: Plant Mol Biol. 2004 Aug;55(6):853-67
references.pmid: 15604721
references.citation: Plant Biol (Stuttg). 2004 Mar-Apr;6(2):178-83
references.pmid: 15045669
references.citation: Plant Cell. 2002 Aug;14(8):1675-90
references.pmid: 12172015
references.citation: Annu Rev Plant Biol. 2007;58:115-36
references.pmid: 17177638
references.citation: Plant J. 2001 Oct;28(2):123-33
references.pmid: 11722756
references.citation: Science. 2003 Aug 1;301(5633):653-7
references.pmid: 12893945
references.citation: Cell Res. 2004 Feb;14(1):8-15
references.pmid: 15040885
references.citation: Plant J. 2005 May;42(4):567-85
references.pmid: 15860015
references.citation: Trends Plant Sci. 2005 Feb;10(2):79-87
references.pmid: 15708345
references.citation: Plant J. 2006 May;46(4):601-12
references.pmid: 16640597
references.citation: Plant Cell. 2008 Feb;20(2):307-19
references.pmid: 18281507
references.citation: Plant Biotechnol J. 2003 Jan;1(1):3-22
references.pmid: 17147676
references.citation: Plant J. 2004 Aug;39(4):612-28
references.pmid: 15272878
references.citation: Plant J. 2003 Dec;36(5):629-42
references.pmid: 14617064
references.citation: New Phytol. 2005 Feb;165(2):429-44
references.pmid: 15720654
references.citation: Plant Biol (Stuttg). 2008 Sep;10 Suppl 1:63-75
references.pmid: 18721312