title: Coffee intake can promote activity of antioxidant enzymes with increasing MDA level and decreasing HDL-cholesterol in physically trained rats.
abstract: This study investigated the effect of coffee intake and exercise on the antioxidative activity and plasma cholesterol profile of physically trained rats while they were exercising. Forty eight rats were under either the control diet with water (C) or control diet with coffee (CF) and at the same time they were given physical training for 4 weeks. In terms of physical training, the rats were exercised on a treadmill for 30 minutes everyday. At the end of 4 weeks, animals in each dietary group were subdivided into 3 groups: before-exercise (BE); during-exercise (DE); after-exercise (AE). Animals in the DE group were exercised on a treadmill for one hour, immediately before being sacrificed. Animals in the AE group were allowed to take a rest for one hour after exercise. TG levels were significantly high in coffee intake group than in control group. Also TG level of AE group was significantly higher than that of BE group. Exercise and coffee-exercise interaction effects were significant in total cholesterol (P = 0.0004, 0.0170). The AE of coffee intake group showed highest total cholesterol levels. HDL-cholesterol was significantly lower in coffee intake group than in control group. Coffee, exercise, and coffee-exercise interaction effects were significant in SOD (P = 0.0001, 0.0001, and 0.0001). The AE and BE of coffee intake group showed higher SOD levels than the other four groups. Catalase activities were significantly higher in coffee intake group than control group. No significant main effect was found in GSH/GSSG. Coffee, exercise, and coffee-exercise interaction effects were significant in MDA levels (P = 0.0464, 0.0016, and 0.0353). The DE and AE of coffee intake group and the DE of control group showed higher MDA levels than the BE of control group. Therefore, coffee intake can promote activities of antioxidant enzyme but it also increases MDA and decreases HDL-cholesterol in physically trained rats.
authors.affiliation: Department of Food & Nutrition, Duksung Women's University, 419 Ssangmun-dong, Dobong-gu, Seoul 132-714, Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Choi
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jang
authors.forename: Youn-Ok
authors.initials: YO
authors.lastname: Cho
references.citation: Ageing Res Rev. 2002 Feb;1(1):79-93
references.pmid: 12039450
references.citation: Breast Cancer Res Treat. 2010 Jan;119(2):477-84
references.pmid: 19437116
references.citation: Biochim Biophys Acta. 1984 Aug 21;800(3):269-76
references.pmid: 6087915
references.citation: J Exp Biol. 1993 Jun;179:159-80
references.pmid: 8340728
references.citation: Clin Exp Pharmacol Physiol. 1997 May;24(5):326-32
references.pmid: 9143782
references.citation: BMJ. 2002 Nov 23;325(7374):1202
references.pmid: 12446535
references.citation: Food Chem Toxicol. 2007 Sep;45(9):1588-92
references.pmid: 17412475
references.citation: J Physiol. 2005 Aug 15;567(Pt 1):113-20
references.pmid: 15932896
references.citation: Can J Physiol Pharmacol. 1998 Dec;76(12):1139-45
references.pmid: 10326836
references.citation: J Nutr Biochem. 2007 Jan;18(1):39-45
references.pmid: 16644199
references.citation: Diabetes. 2002 Mar;51(3):583-90
references.pmid: 11872654
references.citation: Pflugers Arch. 2001 Jun;442(3):426-34
references.pmid: 11484775
references.citation: Free Radic Biol Med. 2008 Jan 15;44(2):126-31
references.pmid: 18191748
references.citation: J Alzheimers Dis. 2009;16(1):85-91
references.pmid: 19158424
references.citation: N Engl J Med. 1983 Jun 16;308(24):1454-7
references.pmid: 6855815
references.citation: Proc Nutr Soc. 1998 Feb;57(1):9-13
references.pmid: 9571703
references.citation: J Sports Sci. 1997 Jun;15(3):353-63
references.pmid: 9232561
references.citation: Toxicology. 2003 Jul 15;189(1-2):41-54
references.pmid: 12821281
references.citation: Circulation. 2009 Mar 3;119(8):1116-23
references.pmid: 19221216
references.citation: J Appl Physiol (1985). 1988 Jan;64(1):115-9
references.pmid: 3356628
references.citation: Coron Artery Dis. 1998;9(5):249-55
references.pmid: 9710684
references.citation: Am J Clin Nutr. 2002 Dec;76(6):1244-8
references.pmid: 12450889
references.citation: Mov Disord. 2007 Nov 15;22(15):2242-8
references.pmid: 17712848
references.citation: J Intern Med. 1995 Jun;237(6):543-50
references.pmid: 7782725
references.citation: Phytochemistry. 2009 Jan;70(1):11-24
references.pmid: 19147161
references.citation: FEBS Lett. 1997 Mar 24;405(2):186-90
references.pmid: 9089288
references.citation: Anal Biochem. 2007 Jan 15;360(2):207-15
references.pmid: 17141173
references.citation: JAMA. 2006 Sep 13;296(10):1255-65
references.pmid: 16968850
references.citation: Appl Physiol Nutr Metab. 2008 Dec;33(6):1301-10
references.pmid: 19088792
references.citation: Metabolism. 1987 Feb;36(2):165-71
references.pmid: 3100910
references.citation: Am J Clin Nutr. 2000 Nov;72(5):1107-10
references.pmid: 11063436
references.citation: Clin Chim Acta. 2000 May;295(1-2):141-54
references.pmid: 10767400
references.citation: Med Sci Monit. 2003 Sep;9(9):BR325-30
references.pmid: 12960921
references.citation: Environ Health Perspect. 1986 Aug;67:89-91
references.pmid: 3757962
references.citation: J Enzyme Inhib Med Chem. 2009 Feb;24(1):287-95
references.pmid: 18825537
references.citation: Clin Nutr. 2006 Jun;25(3):444-53
references.pmid: 16426710
references.citation: Eur J Appl Physiol Occup Physiol. 1996;74(1-2):60-6
references.pmid: 8891501
references.citation: Curr Opin Lipidol. 1995 Feb;6(1):25-7
references.pmid: 7735710
references.citation: Arch Biochem Biophys. 1988 May 15;263(1):150-60
references.pmid: 3369860
references.citation: Ann Nutr Metab. 2006;50(2):132-8
references.pmid: 16391468
references.citation: J Hypertens. 2005 May;23(5):921-8
references.pmid: 15834273
references.citation: J Nutr. 2000 Aug;130(8S Suppl):2073S-85S
references.pmid: 10917926
references.citation: Nutr Res Pract. 2007 Spring;1(1):14-8
references.pmid: 20535380
references.citation: JAMA. 2003 May 21;289(19):2503-4
references.pmid: 12759321
references.citation: Curr Med Chem. 2001 Jun;8(7):829-38
references.pmid: 11375753