title: Magnetic resonance-guided vacuum-assisted breast biopsy: results in 100 Japanese women.
abstract: OBJECTIVE
  The aim of this study was to clarify the frequency of malignancy and the histopathological characteristics of the lesions in patients undergoing magnetic resonance imaging (MRI)-guided vacuum-assisted biopsy (VAB).
  
  
  METHODS
  A retrospective review of 100 consecutive patients with 102 lesions who had undergone MRI-guided VAB was performed. The biopsies were performed on a 1.5-T MR scanner using a commercially available biopsy system. None of the lesions seen with MRI could be detected by mammography or second-look ultrasonography.
  
  
  RESULTS
  The average lesion sizes of the focus, mass, and nonmass lesions before the biopsy were 4.5, 8.2, and 21 mm, respectively. Twelve patients (12%) had lesions located in the deep portion of the breast, close to the pectoral muscle. The biopsy was successfully performed without important side effects in all patients. Histopathological findings were invasive ductal carcinoma in 6 (6%), in situ carcinoma in 28 (27%), and high-risk and benign in 68 (67%). Two high-risk lesions were upgraded to ductal carcinoma in situ (DCIS), and three DCIS lesions were upgraded to invasive ductal carcinoma at surgical excision.
  
  
  CONCLUSIONS
  The high rate of DCIS might be a unique feature among Japanese women. However, MRI-guided VAB is necessary for MRI-only visible suspicious lesions in Japan.
authors.affiliation: Breast Center, Kameda Medical Center, Kamogawa, Japan. e-tozaki@keh.biglobe.ne.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tozaki
authors.forename: Norie
authors.initials: N
authors.lastname: Yamashiro
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Naomi
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Mizuuchi
authors.forename: Eisuke
authors.initials: E
authors.lastname: Fukuma
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007564:Japan; D018810:Magnetic Resonance Angiography; D008875:Middle Aged; D012189:Retrospective Studies; D014618:Vacuum
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
references.citation: AJR Am J Roentgenol. 2009 Sep;193(3):840-9
references.pmid: 19696300
references.citation: Breast Cancer. 2009;16(2):121-5
references.pmid: 18807122
references.citation: Radiology. 1994 Oct;193(1):97-102
references.pmid: 8090928
references.citation: Eur Radiol. 1999;9(8):1656-65
references.pmid: 10525886
references.citation: CA Cancer J Clin. 2007 Mar-Apr;57(2):75-89
references.pmid: 17392385
references.citation: Radiol Med. 2008 Sep;113(6):830-40
references.pmid: 18633687
references.citation: Cancer. 2006 Mar 1;106(5):982-90
references.pmid: 16456807
references.citation: Eur Radiol. 2008 Jul;18(7):1307-18
references.pmid: 18389253
references.citation: Eur Radiol. 2002 Jul;12(7):1720-7
references.pmid: 12111063
references.citation: Eur Radiol. 2010 Jul;20(7):1554-62
references.pmid: 20119729
references.citation: Breast Cancer. 2010 Apr;17(2):110-7
references.pmid: 19434473
references.citation: J Magn Reson Imaging. 2008 Oct;28(4):900-5
references.pmid: 18821610
references.citation: Magn Reson Med Sci. 2007;6(4):259-64
references.pmid: 18239364
references.citation: Radiology. 2006 Jan;238(1):54-61
references.pmid: 16304093
references.citation: Histopathology. 1991 Nov;19(5):403-10
references.pmid: 1757079
references.citation: AJR Am J Roentgenol. 2005 Jul;185(1):183-93
references.pmid: 15972421
references.citation: Breast Cancer. 2008;15(2):169-74
references.pmid: 18317885
references.citation: Eur Radiol. 2002 Jun;12(6):1463-70
references.pmid: 12042955
references.citation: AJR Am J Roentgenol. 2003 Nov;181(5):1283-93
references.pmid: 14573421
references.citation: AJR Am J Roentgenol. 2008 Dec;191(6):1798-804
references.pmid: 19020252