title: Quality of life and social support in patients with multiple sclerosis.
abstract: OBJECTIVE
  The aim of the study was to evaluate quality of life (QoL) in multiple sclerosis (MS) patients and to assess the relationship between QoL and social support taking into account key clinical factors and other sociodemographic variables.
  
  
  METHODS
  Two hundred and ten MS patients (150 women and 60 men) aged between 21 and 59 years were evaluated; the MS group was compared with 108 healthy controls. QoL (MSQOL-54), disease severity (Expanded Disability Status State, EDSS), social support (Social Provisions Scale, SPS), mood (Beck Depression Inventory, BDI) and basic clinical and demographic data were assessed.
  
  
  RESULTS
  Disease severity was mild (EDSS < 4) in 85% of patients, and depressive symptoms (BDI > 13) were present in 41% of patients. Mean physical health composite of MSQOL-54 was 53.6 ± 20.7 and mean mental health composite was 60.0 ± 19.8. MS patients scored significantly lower than healthy subjects. Mean SPS was 78.2 ± 10.9 (range, 6-96) which indicated high social support. In bivariate analysis, social support correlated significantly with the majority of MSQOL domains; in multivariate analysis, however, this relationship was not significant. Emotional well-being was the main predictor of QoL, in both physical and mental domains.
  
  
  CONCLUSIONS
  MS influences QoL but to a greater extent in the physical than the psychological domain. The role of social support in QoL is generally positive but its protective function may be weakened when interacting with other factors. Depression is the main predictor of QoL when adjusted for other factors. Thus, treatment of mood disturbances might significantly improve QoL in MS patients.
authors.affiliation: Zakład Pielêgniarstwa Neurologicznego i Psychiatrycznego, Uniwersytet Medyczny im. Karola Marcinkowskiego,ul. Smoluchowskiego 11, 60-179 Poznań. jaracz@ump.edu.pl
authors.forename: Krystyna
authors.initials: K
authors.lastname: Jaracz
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Pawlak
authors.forename: Krystyna
authors.initials: K
authors.lastname: Górna
authors.forename: Błażeja
authors.initials: B
authors.lastname: Kołcz
authors.forename: Dorota
authors.initials: D
authors.lastname: Wołoszyn
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kozubski
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008603:Mental Health / Q000706:statistics & numerical data*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000523:psychology; D015999:Multivariate Analysis; D011044:Poland / Q000453:epidemiology; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D012944:Social Support; D011795:Surveys and Questionnaires; D055815:Young Adult