title: Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
abstract: Eight new germacrane-type sesquiterpenoids, volvalerenals A-E (2-6) and volvalerenic acids A-C (7-9), along with four known compounds, were isolated from a chloroform extract of the roots of Valeriana officinalis var. latifolia. The structures and relative configurations of 2-9 were elucidated on the basis of spectroscopic data interpretation. The effects of all compounds isolated on acetylcholinesterase were evaluated.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Wang
authors.forename: Xin-Hui
authors.initials: XH
authors.lastname: Ran
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013619:Tacrine / Q000494:pharmacology; D014632:Valerian / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D045788:Sesquiterpenes, Germacrane; D013619:Tacrine