title: [Hybrid nanocarriers for controlled delivery of antitumour and retroviral drugs delivery].
abstract: The efficient delivery of drugs in the body requires the use of non-toxic nanocarriers. Most of the existing materials show poor drug loading and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. The new porous hybrid solids, with the ability to tune their structures and porosities are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III) - based metal - organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of antitumour and retroviral drugs against cancer and AIDS. They also potentially associate therapeutics and diagnostics, and open the way for theranostics, or -personalized patient treatments. double dagger.
authors.affiliation: Institut Lavoisier, Université de Versailles- Saint-Quentin-en-Yvelines, 78035 Versailles, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Horcajada
authors.forename: Christian
authors.initials: C
authors.lastname: Serre
authors.forename: Gérard
authors.initials: G
authors.lastname: Férey
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D002066:Busulfan / Q000737:chemistry / Q000627:therapeutic use; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D063065:Organophosphonates / Q000737:chemistry / Q000627:therapeutic use; D015215:Zidovudine / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D044966:Anti-Retroviral Agents; D000970:Antineoplastic Agents; D004337:Drug Carriers; D063065:Organophosphonates; D015215:Zidovudine; D004317:Doxorubicin; D003596:Cytosine; D002066:Busulfan; D000077404:Cidofovir