title: TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
abstract: BACKGROUND
  Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disorder. Although the pathogenesis of disease is unclear, it is well known that T cells play a major role in both development and perpetuation of RA through activating macrophages and B cells. Since the lack of TNF-Related Apoptosis Inducing Ligand (TRAIL) expression resulted in defective thymocyte apoptosis leading to an autoimmune disease, we explored evidence for alterations in TRAIL/TRAIL receptor expression on peripheral T lymphocytes in the molecular mechanism of RA development.
  
  
  METHODS
  The expression of TRAIL/TRAIL receptors on T cells in 20 RA patients and 12 control individuals were analyzed using flow cytometry. The correlation of TRAIL and its receptor expression profile was compared with clinical RA parameters (RA activity scored as per DAS28) using Spearman Rho Analysis.
  
  
  RESULTS
  While no change was detected in the ratio of CD4+ to CD8+ T cells between controls and RA patient groups, upregulation of TRAIL and its receptors (both death and decoy) was detected on both CD4+ and CD8+ T cells in RA patients compared to control individuals. Death Receptor-4 (DR4) and the decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4+ T cells, were positively correlated with patients' DAS scores.
  
  
  CONCLUSIONS
  Our data suggest that TRAIL/TRAIL receptor expression profiles on T cells might be important in revelation of RA pathogenesis.
authors.affiliation: Department of Medical Genetics, Human Gene and Cell Therapy Center of Akdeniz University Hospitals and Clinics, Antalya, Turkey.
authors.forename: Atil
authors.initials: A
authors.lastname: Bisgin
authors.forename: Ender
authors.initials: E
authors.lastname: Terzioglu
authors.forename: Cigdem
authors.initials: C
authors.lastname: Aydin
authors.forename: Burcak
authors.initials: B
authors.lastname: Yoldas
authors.forename: Veli
authors.initials: V
authors.lastname: Yazisiz
authors.forename: Nilufer
authors.initials: N
authors.lastname: Balci
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bagci
authors.forename: Reginald M
authors.initials: RM
authors.lastname: Gorczynski
authors.forename: Cezmi A
authors.initials: CA
authors.lastname: Akdis
authors.forename: Salih
authors.initials: S
authors.lastname: Sanlioglu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis*; D053320:Receptors, Tumor Necrosis Factor, Member 10c; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D053319:Tumor Necrosis Factor Decoy Receptors / Q000096:biosynthesis*
chemical_list: D058851:GPI-Linked Proteins; D018124:Receptors, Tumor Necrosis Factor; D053320:Receptors, Tumor Necrosis Factor, Member 10c; C108661:TNFRSF10C protein, human; C451501:TNFRSF10D protein, human; D053319:Tumor Necrosis Factor Decoy Receptors; C509611:decoy receptor 2, rat
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