title: Lidocaine spray 10 min prior to intubation: effects on postoperative sore throat.
abstract: A sore throat is the most frequent adverse side effect of general anesthesia. The purpose of this study was to compare the different types and timing of lidocaine application based on the effectiveness of reducing postoperative sore throat (POST) after endotracheal intubation. In group A, 8% lidocaine was sprayed on laryngopharyngeal structures immediately before intubation, and the distal ends of the endotracheal tubes (ETTs) were lubricated with 2% lidocaine gel. In group B, 8% lidocaine was sprayed, and ETTs were lubricated with normal saline. In groups C and D, no lidocaine was sprayed, and the ETTs were lubricated with normal saline (C, control) or with 2% lidocaine gel (D). In group E, 8% lidocaine was sprayed 10 min prior to endotracheal intubation, and the ETTs were lubricated with normal saline. In 527 patients, 28.2% reported POST at 24 h following extubation. Statistically significant differences in the incidence of POST were found only between group E (16.0%) and each of the other groups (28.4-38.5%), except for group B (26.5%). In conclusion, 8% lidocaine spray significantly reduced the incidence of POST if it was sprayed on laryngopharyngeal structures 10 min prior to endotracheal intubation.
authors.affiliation: Division of Surgical Operation Center, Akiru Municipal Medical Center, 78-1 Hikida, Akiruno, Tokyo 197-0834, Japan. khonma@tc5.so-net.ne.jp
authors.forename: Kaneatsu
authors.initials: K
authors.lastname: Honma
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kamachi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Akamatsu
authors.forename: Masami
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Natsumi
authors.initials: N
authors.lastname: Yamashita
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010612:Pharyngitis / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D012307:Risk Factors
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine
references.citation: J Clin Anesth. 1997 Feb;9(1):42-7
references.pmid: 9051545
references.citation: Anaesthesia. 1992 Mar;47(3):213-6
references.pmid: 1566989
references.citation: Br J Pharmacol. 2007 May;151(1):153-60
references.pmid: 17351650
references.citation: Eur J Anaesthesiol. 2000 Jul;17(7):436-42
references.pmid: 10964145
references.citation: Anaesthesia. 1993 Apr;48(4):355-6
references.pmid: 8494161
references.citation: J Dent. 2009 Feb;37(2):93-7
references.pmid: 19058888
references.citation: J Clin Anesth. 1997 Aug;9(5):394-7
references.pmid: 9257206
references.citation: Eur J Anaesthesiol. 1988 Nov;5(6):391-9
references.pmid: 3240760
references.citation: Anaesthesia. 1999 May;54(5):444-53
references.pmid: 10995141
references.citation: Anesth Analg. 1997 Sep;85(3):573-7
references.pmid: 9296411
references.citation: Anaesthesia. 1987 Oct;42(10):1104-7
references.pmid: 3688395
references.citation: Br J Anaesth. 1994 Dec;73(6):786-7
references.pmid: 7880666
references.citation: Can Anaesth Soc J. 1980 Mar;27(2):156-8
references.pmid: 7363144
references.citation: J Clin Anesth. 2004 Feb;16(1):79-80; author reply 80
references.pmid: 14984868
references.citation: J Clin Anesth. 2002 Feb;14(1):15-8
references.pmid: 11880016