title: Paraneoplastic motor neuron disease associated with Purkinje cell autoantibody type 1.
abstract: Motor neuron disease has been reported as a rare result of systemic cancers, likely related to an autoimmune effecter mechanism. These patients have been described as having a more rapid onset of symptoms than typical motor neuron disease. Few of these reports demonstrate an association of a cancer-related autoantibody and with motor neuron disease. We present a 54-year-old woman with infiltrating ductal carcinoma of the breast who later developed lower motor neuron disease and was found to have Purkinje cell autoantibodies type 1. The association of lower motor neuron disease as a consequence of breast cancer with this autoantibody profile has not been described previously. This report emphasizes the importance of considering a paraneoplastic syndrome in a patient with an uncommon presentation of motor neuron disease.
authors.affiliation: Department of Neurology, University of Washington School Of Medicine, Seattle, WA, USA. jdistad@uw.edu
authors.forename: B Jane
authors.initials: BJ
authors.lastname: Distad
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weiss
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000276:immunology*; D011689:Purkinje Cells / Q000276:immunology* / Q000473:pathology
chemical_list: D000912:Antibodies, Neoplasm; D001323:Autoantibodies; C095184:CDR2 protein, human; D009419:Nerve Tissue Proteins