Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy.
Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p < 0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component.
van Dijk
Hille W
HW
Dept of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands. h.w.vandijk@amc.nl
Verbraak
Frank D
FD
Stehouwer
Marilette
M
Kok
Pauline H B
PH
Garvin
Mona K
MK
Sonka
Milan
M
DeVries
J Hans
JH
Schlingemann
Reinier O
RO
Abràmoff
Michael D
MD
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult
Ophthalmology. 1991 May;98(5 Suppl):786-806
2062513
Ophthalmology. 2003 Sep;110(9):1677-82
13129861
Graefes Arch Clin Exp Ophthalmol. 1996 May;234(5):300-5
8740250
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3660-5
20130282
Prog Retin Eye Res. 2006 Sep;25(5):425-48
16949855
Br J Ophthalmol. 2007 Dec;91(12):1596-8
17591672
Diabetes Care. 2004 Jan;27 Suppl 1:S84-7
14693935
Retina. 2009 May;29(5):618-26
19262432
Nat Neurosci. 2001 Sep;4(9):877-86
11528418
Graefes Arch Clin Exp Ophthalmol. 2002 Feb;240(2):79-84
11931083
Arch Ophthalmol. 2009 Jul;127(7):875-81
19597108
Diabetes Care. 1992 May;15(5):620-5
1516480
Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1971-80
10845624
Diabetes. 2006 Sep;55(9):2401-11
16936187
Diabetologia. 2003 Sep;46(9):1260-8
12898017
Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3330-6
15326158
IEEE Trans Med Imaging. 2009 Sep;28(9):1436-47
19278927
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2635-42
18515593
Ophthalmology. 2009 Dec;116(12):2305-14.e1-2
19744726
Clin Exp Optom. 2006 Mar;89(2):81-5
16494610
J Physiol. 2008 Sep 15;586(18):4401-8
18565995
Clin Exp Ophthalmol. 2008 Jul;36(5):455-63
18925914
Ophthalmic Physiol Opt. 2005 Mar;25(2):81-6
15713199
Surv Ophthalmol. 2002 Dec;47 Suppl 2:S253-62
12507627
J Clin Invest. 1998 Aug 15;102(4):783-91
9710447
Vision Res. 2002 Jul;42(15):1931-9
12128022
Ophthalmology. 2008 Mar;115(3):533-539.e2
18067962
Ophthalmology. 2004 Nov;111(11):2133-6
15522382
Graefes Arch Clin Exp Ophthalmol. 2001 Sep;239(9):643-8
11688662
Invest Ophthalmol Vis Sci. 2002 Sep;43(9):3109-16
12202536
Invest Ophthalmol Vis Sci. 2000 Mar;41(3):741-8
10711689
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3404-9
19151397
Br J Ophthalmol. 2007 Sep;91(9):1135-8
17383994
Br J Ophthalmol. 1992 Aug;76(8):461-4
1390526
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):283-90
12657367
Graefes Arch Clin Exp Ophthalmol. 1984;222(2):71-4
6519442
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3143-50
16799061
Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2760-6
15277502
Eye (Lond). 2009 Apr;23(4):884-9
18437178
Ophthalmology. 2008 Jun;115(6):949-56
17981334
Prog Retin Eye Res. 2007 Nov;26(6):688-710
17889587
Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8
15914643
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5320-31
17962489
Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5356-62
17122124
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1622-8
18385083
Vision Res. 1973 Nov;13(11):2113-20
4763524