Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands.
Zaminer
Jan
J
Universität zu Köln, Department für Chemie, Greinstrasse 4, 50939 Köln, Germany.
Brockmann
Christoph
C
Huy
Peter
P
Opitz
Robert
R
Reuter
Cédric
C
Beyermann
Michael
M
Freund
Christian
C
Müller
Matthias
M
Oschkinat
Hartmut
H
Kühne
Ronald
R
Schmalz
Hans-Günther
HG
D000595:Amino Acid Sequence; D004151:Dipeptides / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D055232:Proline-Rich Protein Domains; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D013237:Stereoisomerism
D004151:Dipeptides; D008024:Ligands; D010455:Peptides; C448039:prolyl-proline