title: Aborted cardiac arrest in a patient carrying KCNE1 D85N variant during the postpartum period.
abstract: The postpartum period is associated with an increased risk of fatal ventricular tachyarrhythmias in patients with congenital long QT syndrome (LQTS). We describe a 20-year-old female with LQTS who experienced aborted cardiac arrest during the postpartum period. Genetic screening identified a KCNE1 D85N variant, which has been reported to be a LQTS-causing gene variant, in the patient and her younger sister, whose QT interval was also prolonged. Since the allele frequency of this variant is almost 1%, it may be important to clarify whether such variant carriers indeed have an increased risk of fatal ventricular tachyarrhythmias during the postpartum period.
authors.affiliation: Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Japan. tnakajim@med.gunma-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Mamoru
authors.initials: M
authors.lastname: Manita
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Iso
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000483:Alleles; D001919:Bradycardia / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D007774:Lactation; D008133:Long QT Syndrome / Q000150:complications / Q000151:congenital / Q000235:genetics* / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000209:etiology; D017354:Point Mutation; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*; D011644:Puerperal Disorders / Q000235:genetics*; D035781:Siblings; D017180:Tachycardia, Ventricular / Q000209:etiology; D055815:Young Adult
chemical_list: C489622:KCNE1 protein, human; D024642:Potassium Channels, Voltage-Gated