title: Microbiological and therapeutical aspects of pneumococcal diseases in the Slovak Republic.
abstract: Since 1983, multiresistant pneumococcal strains, mostly 14, 23F, 19A serotypes have been reported in Slovakia. A 15-year cooperation of specialists from various fields and the representatives of different institutions revealed that the pneumococcal infection problem in the Slovak Republic remains an important healthcare task. In the prospective multicentric microbiological and clinical analysis of otitis media acuta in children under 5 years, pneumococci were isolated in 45.9%, where 50.8% of strains were intermediate and fully resistant to penicillin and 47.5% resistant to macrolid antibiotics. Invasive pneumococcal infections, mostly meningitis and bacteremias, were observed in two studies. Penicillin resistance was higher in children under 5 years (52.8%), in comparison with other age groups. The dominant serotypes of childhood were 14, 19A and 6A, while in the age group above 65 there was a broad spectrum of serotypes confirmed. Serotype 14 is the most frequent serotype in physiologically sterile liquids and otitis media liquor in the Slovak Republic (Tab. 3, Fig. 5, Ref. 34).
authors.affiliation: Institut of Microbiology, Medical Faculty of the Comenius University and University Hospital, Bratislava, Slovakia. helena.hupkova@fmed.uniba.sk
authors.forename: H
authors.initials: H
authors.lastname: Hupkova
authors.forename: J
authors.initials: J
authors.lastname: Trupl
authors.forename: I
authors.initials: I
authors.lastname: Stankovic
authors.forename: P
authors.initials: P
authors.lastname: Simurka
authors.forename: M
authors.initials: M
authors.lastname: Bukovsky
authors.forename: M
authors.initials: M
authors.lastname: Gezo
mesh_terms: D002648:Child; D024881:Drug Resistance, Bacterial; D006801:Humans; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D012703:Serotyping; D018154:Slovakia
chemical_list: D022242:Pneumococcal Vaccines