Variable evolutionary signatures at the heart of enhancers.
What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint.
Hardison
Ross C
RC
D004742:Enhancer Elements, Genetic / Q000235:genetics*; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D014644:Genetic Variation / Q000502:physiology*; D006321:Heart / Q000196:embryology / Q000254:growth & development; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D016415:Sequence Alignment; D013045:Species Specificity
Science. 2010 May 21;328(5981):1036-40
20378774
Nature. 2007 Jun 14;447(7146):799-816
17571346
Nature. 2006 Nov 23;444(7118):499-502
17086198
Nat Rev Genet. 2005 Feb;6(2):151-7
15716910
Genome Res. 2007 Jun;17(6):760-74
17567995
Nat Genet. 2010 Sep;42(9):806-10
20729851
Nat Genet. 2007 Mar;39(3):311-8
17277777
Genome Res. 2007 Jun;17(6):775-86
17567996