Fractionated radiotherapy for intracranial meningiomas.
Fractionated external beam radiotherapy (EBRT) has multiple roles in the management of intracranial meningiomas. In multiple series post-operative EBRT has shown improved progression-free survival following subtotal resection and a reduction in long-term failures following an apparent gross total resection. In the definitive setting, the use of EBRT has increased as the growing utilization of neuro-imaging for various conditions identifies skull-based lesions which are not easily resectable. Optic nerve sheath meningiomas represent a classic example of the use of definitive EBRT, given the frequent visual sequelae of surgery or observation. EBRT planning is highly individualized and requires a detailed understanding of tumor grade, adjacent radiosensitive structures such as the anterior optic apparatus, and radiographic characteristics of the tumor such as hyperostosis.
Gondi
Vinai
V
Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA. gondi@humonc.wisc.edu
Tome
Wolfgang A
WA
Mehta
Minesh P
MP
D019583:Dose Fractionation, Radiation; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008579:Meningioma / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
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