title: Rapid formation of hindered cores using an oxidative Prins process.
abstract: An unprecedented oxidative Prins transformation on phenol derivatives mediated by a hypervalent iodine reagent has been developed. This method allows a rapid access to highly substituted compact systems present in several natural products via a carbon-based addition on an aromatic core. Substitution at each ring position has been demonstrated, enabling synthesis of molecules with up to two contiguous quaternary carbon centers in good yield.
authors.affiliation: Laboratoire de Méthodologie et Synthèse de Produits Naturels, Université du Québec à Montréal, C.P. 8888, Succ. Centre-Ville, Montréal, H3C 3P8, Québec, Canada.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Andrez
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Giroux
authors.forename: Jessica
authors.initials: J
authors.lastname: Lucien
authors.forename: Sylvain
authors.initials: S
authors.lastname: Canesi