title: Tumour necrosis factor-alpha polymorphisms and hepatocellular carcinoma: a meta-analysis.
abstract: The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. To summarize the quantitative association between polymorphisms of the tumour necrosis factor-alpha (TNFA) gene and HCC, a meta-analysis of relevant studies was performed. Ten case-control studies involving 1421 HCC cases were identified from the Medline, Embase and Current Contents databases. Combined results based on all studies showed that patients with HCC had a significantly lower frequency of the TNFA gene polymorphism -308GG than healthy controls. When stratifying for race, results were similar among Asians and Caucasians. When comparing with hepatitis B virus infection cases, no statistical association was found. This meta-analysis suggests that TNFA -308GG gene polymorphism is associated with a modest decrease in the risk of HCC.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: H
authors.initials: H
authors.lastname: Qin
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Shi
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
mesh_terms: D044466:Asian People / Q000208:ethnology; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics*; D016206:Databases, Bibliographic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000208:ethnology
chemical_list: D014409:Tumor Necrosis Factor-alpha