Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets.
The role of respiratory viruses in the transmission of Streptococcus pneumoniae is poorly understood. Key questions, such as which serotypes are most fit for transmission and disease and whether influenza virus alters these parameters in a serotype-specific manner, have not been adequately studied. In a novel model of transmission in ferrets, we demonstrated that pneumococcal transmission and disease were enhanced if donors had previously been infected with influenza virus. Bacterial titers in nasal wash, the incidence of mucosal and invasive disease, and the percentage of contacts that were infected all increased. In contact ferrets, viral infection increased their susceptibility to S. pneumoniae acquisition both in terms of the percentage infected and the distance over which they could acquire infection. These influenza-mediated effects on colonization, transmission, and disease were dependent on the pneumococcal strain. Overall, these data argue that the relationship between respiratory viral infections, acquisition of pneumococci, and development of disease in humans needs further study to be better understood.
McCullers
Jonathan A
JA
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
McAuley
Julie L
JL
Browall
Sarah
S
Iverson
Amy R
AR
Boyd
Kelli L
KL
Henriques Normark
Birgitta
B
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005289:Ferrets / Q000382:microbiology / Q000821:virology; D054884:Host-Pathogen Interactions; D009980:Influenza A virus / Q000276:immunology*; D053208:Kaplan-Meier Estimate; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology* / Q000382:microbiology / Q000401:mortality / Q000635:transmission* / Q000821:virology; D013296:Streptococcus pneumoniae / Q000502:physiology*
N Engl J Med. 1982 Jun 10;306(23):1377-83
6281639
J Infect Dis. 2009 Apr 1;199(7):1032-42
19203261
J Infect Dis. 1975 Jul;132(1):62-8
169309
J Infect Dis. 2004 Mar 1;189(5):785-96
14976594
PLoS Pathog. 2007 Mar;3(3):e28
17381239
Mol Microbiol. 2002 Sep;45(5):1389-406
12207705
Comp Med. 2007 Feb;57(1):82-9
17348295
Infect Immun. 1998 Dec;66(12):5620-9
9826334
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12907-12
17644611
Pediatr Infect Dis J. 2004 Jan;23(1 Suppl):S87-97
14730275
Vaccine. 2009 May 11;27(21):2877-83
19366579
Mol Microbiol. 2001 May;40(3):555-71
11359563
J Infect Dis. 1980 Dec;142(6):923-33
7462701
J Infect Dis. 2005 Sep 1;192(5):791-800
16088828
Pediatr Infect Dis J. 2005 Sep;24(9):801-6
16148847
Cell Host Microbe. 2007 Oct 11;2(4):240-9
18005742
Clin Infect Dis. 2004 Mar 1;38(5):632-9
14986245
J Infect Dis. 2003 Mar 15;187(6):1000-9
12660947
Pediatr Infect Dis. 1986 Mar-Apr;5(2):201-7
3952010
Clin Microbiol Rev. 2006 Jul;19(3):571-82
16847087
Pharmacotherapy. 2005 Sep;25(9):1193-212
16164394
Infect Immun. 2001 May;69(5):3350-8
11292758
Infect Immun. 2006 May;74(5):2562-7
16622191
J Infect Dis. 2002 Aug 1;186(3):341-50
12134230