title: Fyodorov-Zuev keratoprosthesis implantation: long-term results in patients with multiple failed corneal grafts.
abstract: BACKGROUND
  The long term results of the Fyodorov-Zuev keratoprosthesis are presented for ten patients with repeated graft failures.
  
  
  METHODS
  The study took place at Dr Khodadoust Eye Hospital. The Fyodorov-Zuev keratoprosthesis was implanted in ten patients with repeated graft failures, including seven patients with old trachoma, two patients with chemical injury, and a patient with thermal injury. The outcome measures were visual acuity, retention, and complications of the keratoprosthesis.
  
  
  RESULTS
  Preoperative best-uncorrected visual acuity (BUVA) ranged from counting fingers to light perception (median: light perception). The keratoprosthesis dramatically improved vision in most patients. Patients retained BUVA of 20/200-20/50 in 50%, 20/60-20/100 in 30%, 20/200 in 10% and 20/400 in 10%. Overall, 90% had 1 year postoperative vision of 20/200 or better. 70% of cases had BUVA of 20/200 or better at the last follow-up (average 52 months). Of ten keratoprosthesis implanted, three have been removed, and as a result, retention rate was 70% during average follow-up of 52 months .The most common postoperative complications were retroprosthetic membrane formation (40%), uveitis (20%), glaucoma (20%), tissue overgrowth (20%), early leakage (20%), late leakage (20%), aseptic necrosis (20%), retinal detachment (10%), endophthalmitis (10%), and granulation tissue growth (10%).
  
  
  CONCLUSIONS
  Fyodorov-Zuev keratoprosthesis is an effective means of managing repeated corneal graft failure.
authors.affiliation: Dr. Khodadoust Eye Hospital, Shiraz, Fars, Iran. Alirezaghaffariyeh@hotmail.com
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghaffariyeh
authors.forename: Nazafarin
authors.initials: N
authors.lastname: Honarpisheh
authors.forename: Akbar
authors.initials: A
authors.lastname: Karkhaneh
authors.forename: Reza
authors.initials: R
authors.lastname: Abudi
authors.forename: Zinaida Ivanovna
authors.initials: ZI
authors.lastname: Moroz
authors.forename: Alireza
authors.initials: A
authors.lastname: Peyman
authors.forename: Abolhasan
authors.initials: A
authors.lastname: Faramarzi
authors.forename: Fuad
authors.initials: F
authors.lastname: Abasov
mesh_terms: D000328:Adult; D000368:Aged; D003316:Corneal Diseases / Q000601:surgery*; D016039:Corneal Transplantation; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D012008:Recurrence; D012086:Reoperation; D017211:Treatment Failure; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology
references.citation: Int Ophthalmol Clin. 2005 Fall;45(4):49-59
references.pmid: 16199966
references.citation: CLAO J. 2002 Apr;28(2):72-4
references.pmid: 12054373
references.citation: Ophthalmology. 2001 Mar;108(3):461-9
references.pmid: 11237899
references.citation: Graefes Arch Clin Exp Ophthalmol. 2000 Dec;238(12):1002-8
references.pmid: 11196352
references.citation: Arch Ophthalmol. 2002 May;120(5):559-66
references.pmid: 12003604
references.citation: Graefes Arch Clin Exp Ophthalmol. 2003 Jul;241(7):571-576
references.pmid: 12819978
references.citation: Arch Ophthalmol. 2001 Apr;119(4):484-9
references.pmid: 11296013
references.citation: Bull World Health Organ. 2001;79(3):214-21
references.pmid: 11285665
references.citation: Vestn Ross Akad Med Nauk. 2007;(8):16-20
references.pmid: 17915471
references.citation: Ophthalmology. 1982 Jun;89(6):655-60
references.pmid: 7122044
references.citation: Zhonghua Yan Ke Za Zhi. 2003 Oct;39(10):578-81
references.pmid: 14766069
references.citation: Ophthalmology. 1998 Apr;105(4):751-7
references.pmid: 9544652
references.citation: Am J Ophthalmol. 2005 Dec;140(6):1032-1038
references.pmid: 16376647
references.citation: Ophthalmology. 2009 Apr;116(4):640-51
references.pmid: 19243830
references.citation: Graefes Arch Clin Exp Ophthalmol. 2010 Mar;248(3):447-50
references.pmid: 20012644
references.citation: Cornea. 2005 Nov;24(8):915-9
references.pmid: 16227832
references.citation: Cornea. 2001 Jan;20(1):19-23
references.pmid: 11188997
references.citation: Dev Ophthalmol. 2008;41:171-186
references.pmid: 18453768
references.citation: Br J Ophthalmol. 2004 Dec;88(12):1585-9
references.pmid: 15550368
references.citation: Ophthalmology. 2006 Oct;113(10):1779.e1-7
references.pmid: 16872678
references.citation: Am J Ophthalmol. 2010 Feb;149(2):221-228.e2
references.pmid: 19939347
references.citation: Cornea. 2005 Aug;24(6):692-8
references.pmid: 16015088
references.citation: Am J Ophthalmol. 2008 Mar;145(3):438-44
references.pmid: 18207122
references.citation: Graefes Arch Clin Exp Ophthalmol. 1999 Apr;237(4):308-12
references.pmid: 10208264