CD14 : a candidate biomarker for the prognosis of polycystic kidney disease.
Zhou et al. validate the expression of markers of the innate immune system in the cpk mouse model of polycystic kidney disease (PKD), in human recessive PKD, and in human autosomal dominant PKD and show that CD14 expression correlates with PKD progression, even from very early stages of disease. Moreover, they show that CD14 is expressed from the renal tubule epithelial cells, suggesting a mechanism of Toll-like receptor-4 activation in PKD prior to the infiltration of inflammatory cells.
Vanden Heuvel
Gregory B
GB
Department of Anatomy and Cell Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. gvandenheuvel@kumc.edu
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D018950:Lipopolysaccharide Receptors / Q000032:analysis*; D051379:Mice; D007690:Polycystic Kidney Diseases / Q000175:diagnosis*; D051197:Toll-Like Receptor 4 / Q000378:metabolism
D015415:Biomarkers; D018950:Lipopolysaccharide Receptors; C495345:TLR4 protein, human; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4
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