title: β-TCP versus autologous bone for repair of alveolar clefts in a goat model.
abstract: OBJECTIVE
  The aim of this study in goats was to test the hypothesis that a novel synthetic bone substitute beta tricalcium phosphate (β-TCP) can work as well as autologous bone harvested from the iliac crest for grafting and repair of alveolar clefts.
  
  
  METHODS
  Ten adult Dutch milk goats (Capra hircus) were used in a split-mouth study design.
  
  
  METHODS
  Volumetric histologic assessment of new bone formation and radiographic measurement of orthodontic movement of teeth in a formerly created alveolar cleft.
  
  
  CONCLUSIONS
  The synthetic bone substitute β-TCP was shown to result in bone healing similar to that of iliac crest bone. The surgical, orthodontic, and histologic results now warrant the testing of β-TCP in the human cleft situation.
authors.forename: Ad
authors.initials: A
authors.lastname: de Ruiter
authors.forename: Gert
authors.initials: G
authors.lastname: Meijer
authors.forename: Titiaan
authors.initials: T
authors.lastname: Dormaar
authors.forename: Nard
authors.initials: N
authors.lastname: Janssen
authors.forename: Andries
authors.initials: A
authors.lastname: van der Bilt
authors.forename: Piet
authors.initials: P
authors.lastname: Slootweg
authors.forename: Joost
authors.initials: J
authors.lastname: de Bruijn
authors.forename: Linda
authors.initials: L
authors.lastname: van Rijn
authors.forename: Ronald
authors.initials: R
authors.lastname: Koole
mesh_terms: D000539:Alveolar Process / Q000601:surgery*; D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002972:Cleft Palate / Q000601:surgery*; D004195:Disease Models, Animal; D006041:Goats; D007085:Ilium / Q000637:transplantation*; D016382:Orthodontic Appliance Design; D017289:Orthodontic Appliances, Functional; D010012:Osteogenesis; D014182:Transplantation, Autologous
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate