Spatial organization acts on cell signaling: how physical force contributes to the development of cancer.
Cells constantly encounter physical forces and respond to neighbors and circulating factors by triggering intracellular signaling cascades that in turn affect their behavior. The mechanisms by which cells transduce mechanical signals to downstream biochemical changes are not well understood. In their work, Salaita and coworkers show that the spatial organization of cell surface receptors is crucial for mechanotransduction. Consequently, force modulation that disrupts the mechanochemical coupling may represent a critical step in cancerogenesis.
Plodinec
Marija
M
M.E.Müller Institute for Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel/Switzerland.
Schoenenberger
Cora-Ann
CA
D000205:Actomyosin / Q000502:physiology; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D045744:Cell Line, Tumor; D048430:Cell Shape / Q000502:physiology; D036382:Ephrin-A1 / Q000378:metabolism; D005260:Female; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D011485:Protein Binding; D036104:Receptor, EphA2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D036382:Ephrin-A1; D000205:Actomyosin; D036104:Receptor, EphA2
Osteoarthritis Cartilage. 2000 Jul;8(4):272-8
10903881
Science. 2010 Mar 12;327(5971):1380-5
20223987
Nat Rev Mol Cell Biol. 2006 Apr;7(4):265-75
16607289
Annu Rev Biomed Eng. 2007;9:1-34
17461730
Cell. 2005 Apr 8;121(1):127-39
15820684
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7791-6
18505845
Cancer Res. 2001 Mar 1;61(5):2301-6
11280802
Curr Opin Cell Biol. 2007 Feb;19(1):101-7
17174543
J Cell Sci. 2003 Jul 15;116(Pt 14):2823-32
12808016
Cancer Metastasis Rev. 2009 Jun;28(1-2):113-27
19153673
Science. 2005 Nov 18;310(5751):1139-43
16293750
Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2101-7
18787190
Cancer Cell. 2005 Sep;8(3):241-54
16169468