title: The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting.
authors.affiliation: Centre for Documentation and Evaluation of Alternatives to Animal Experiments, Federal Institute for Risk Assessment , Berlin, Germany. Sarah.Adler@bfr.bund.de
authors.forename: Sarah
authors.initials: S
authors.lastname: Adler
authors.forename: Gerd
authors.initials: G
authors.lastname: Bicker
authors.forename: Hans
authors.initials: H
authors.lastname: Bigalke
authors.forename: Christopher
authors.initials: C
authors.lastname: Bishop
authors.forename: Jörg
authors.initials: J
authors.lastname: Blümel
authors.forename: Dirk
authors.initials: D
authors.lastname: Dressler
authors.forename: Joan
authors.initials: J
authors.lastname: Fitzgerald
authors.forename: Frank
authors.initials: F
authors.lastname: Gessler
authors.forename: Heide
authors.initials: H
authors.lastname: Heuschen
authors.forename: Birgit
authors.initials: B
authors.lastname: Kegel
authors.forename: Andreas
authors.initials: A
authors.lastname: Luch
authors.forename: Catherine
authors.initials: C
authors.lastname: Milne
authors.forename: Andrew
authors.initials: A
authors.lastname: Pickett
authors.forename: Heidemarie
authors.initials: H
authors.lastname: Ratsch
authors.forename: Irmela
authors.initials: I
authors.lastname: Ruhdel
authors.forename: Dorothea
authors.initials: D
authors.lastname: Sesardic
authors.forename: Martin
authors.initials: M
authors.lastname: Stephens
authors.forename: Gerhard
authors.initials: G
authors.lastname: Stiens
authors.forename: Peter D
authors.initials: PD
authors.lastname: Thornton
authors.forename: René
authors.initials: R
authors.lastname: Thürmer
authors.forename: Martin
authors.initials: M
authors.lastname: Vey
authors.forename: Horst
authors.initials: H
authors.lastname: Spielmann
authors.forename: Barbara
authors.initials: B
authors.lastname: Grune
authors.forename: Manfred
authors.initials: M
authors.lastname: Liebsch
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000826:Animal Testing Alternatives / Q000331:legislation & jurisprudence / Q000379:methods*; D000818:Animals; D001905:Botulinum Toxins / Q000633:toxicity*; D003964:Diaphragm / Q000187:drug effects / Q000502:physiology; D005060:Europe; D007928:Lethal Dose 50; D051379:Mice; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D015203:Reproducibility of Results
chemical_list: D001905:Botulinum Toxins; D000109:Acetylcholine