title: Expression of Dpp6 in mouse embryonic craniofacial development.
abstract: Dipeptidyl-peptidase-like protein 6 (DPP6), a member of the dipeptidyl aminopeptidase family, plays distinct roles in brain development, but its expression in embryonic craniofacial development is unknown. The expression pattern of Dpp6 in the maxillofacial region during mouse embryonic craniofacial development was analyzed by whole-mount in situ hybridization on sections and by real-time PCR analysis. Dpp6 expression was detected during mouse embryonic craniofacial development in embryos 11-13.5 days post-coitum (dpc). Real-time PCR showed high Dpp6 expression present in 11.5-13.5dpc, and this then decreased as development of maxillofacial region progressed. The expression pattern of Dpp6 suggests that Dpp6 may be involved in embryonic craniofacial development.
authors.affiliation: Molecular Laboratory for Gene Therapy and Tooth Regeneration, Capital Medical University School of Stomatology, Beijing, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Fan
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Yuanrong
authors.initials: Y
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Shuhong
authors.initials: S
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
authors.forename: Songlin
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics*; D005145:Face / Q000196:embryology*; D017403:In Situ Hybridization; D008445:Maxillofacial Development; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger; C569992:DPP6 protein, mouse; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases