title: Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes.
abstract: OBJECTIVE
  Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain.
  
  
  METHODS
  Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping.
  
  
  CONCLUSIONS
  Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.
authors.affiliation: Fonds de la Recherche Scientifique (FNRS), Laboratoire de Neurologie Expérimentale, Université Libre de Bruxelles, Belgium. naygunko@ulb.ac.be
authors.forename: Neslihan Aygun
authors.initials: NA
authors.lastname: Kocabas
authors.forename: Irina
authors.initials: I
authors.lastname: Antonijevic
authors.forename: Carole
authors.initials: C
authors.lastname: Faghel
authors.forename: Carlos
authors.initials: C
authors.lastname: Forray
authors.forename: Siegfried
authors.initials: S
authors.lastname: Kasper
authors.forename: Yves
authors.initials: Y
authors.lastname: Lecrubier
authors.forename: Sylvie
authors.initials: S
authors.lastname: Linotte
authors.forename: Isabelle
authors.initials: I
authors.lastname: Massat
authors.forename: Stuart
authors.initials: S
authors.lastname: Montgomery
authors.forename: Magali
authors.initials: M
authors.lastname: Noro
authors.forename: Pierre
authors.initials: P
authors.lastname: Oswald
authors.forename: Lenore
authors.initials: L
authors.lastname: Snyder
authors.forename: Daniel
authors.initials: D
authors.lastname: Souery
authors.forename: Joseph
authors.initials: J
authors.lastname: Zohar
authors.forename: Julien
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D059020:Suicidal Ideation
chemical_list: D000928:Antidepressive Agents; D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins