Antihypertensive activity of newer 1,4-dihydro-5-pyrimidine carboxamides: synthesis and pharmacological evaluation.
A number of 5-(4-substituted phenyl)-2-(substituted benzylsulfanyl)-4-(substituted phenyl)-6-methyl-1,4-dihydro-5-pyrimidine carboxamides (1-30) were designed and synthesized keeping in view the structural requirements as suggested in the pharmacophore model for antihypertensive activity. All the synthesized compounds were tested for antihypertensive activity by non-invasive blood pressure (NIBP) measurements (tail-cuff method) in rats. Almost all the tested compounds displayed considerable decrease in the blood pressure as compared to control. Thirteen compounds showed significant antihypertensive activity comparable to the standard drug nifedipine.
Alam
Ozair
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi 110062, India. oalam@jamiahamdard.ac.in
Khan
Suroor A
SA
Siddiqui
Nadeem
N
Ahsan
Waquar
W
Verma
Suraj P
SP
Gilani
Sadaf J
SJ
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D003900:Desoxycorticosterone / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared
D000959:Antihypertensive Agents; D011743:Pyrimidines; D003900:Desoxycorticosterone