title: Dihydro-resveratrol--a potent dietary polyphenol.
abstract: Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562).
authors.affiliation: Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA. gakhaa@ornl.gov
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Gakh
authors.forename: Natalia Yu
authors.initials: NY
authors.lastname: Anisimova
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Kiselevsky
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Sadovnikov
authors.forename: Ivan N
authors.initials: IN
authors.lastname: Stankov
authors.forename: Mikhail V
authors.initials: MV
authors.lastname: Yudin
authors.forename: Konstantin A
authors.initials: KA
authors.lastname: Rufanov
authors.forename: Mikhail Yu
authors.initials: MY
authors.lastname: Krasavin
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Sosnov
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D019587:Dietary Supplements; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*; D014920:Wine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol