Highly efficient iridium-catalyzed asymmetric hydrogenation of unprotected β-enamine esters.
A highly efficient and enantioselective hydrogenation of unprotected β-enamine esters catalyzed by Ir-(S,S)-f-Binaphane complex has been developed. This methodology provides straightforward access to free β-amino acids in high yields with excellent enantioselectivities up to 97% ee and high reactivities (TON > 5000).
Hou
Guohua
G
Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Li
Wei
W
Ma
Miaofeng
M
Zhang
Xiaowei
X
Zhang
Xumu
X
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000588:Amines; D004952:Esters; D007495:Iridium