Acute carbamazepine poisoning treated with resin hemoperfusion successfully.
Carbamazepine (CBZ) poisoning has been occurring more frequently. We describe the use of synthesized resin-absorbed hemoperfusion in the therapy of a 48-year-old man who developed carotic, cardiovascular shock and multiorgan dysfunction due to a CBZ overdose (the highest concentration of drug >20 mg/L; therapeutic range, 8-12 mg/L). The treatment was very successful; and the patient eventually was discharged with a full recovery and no complications, although his diagnosis and treatment had been delayed for 56 hours. Hemoperfusion has a steady clearance of this drug without subsequent rebound or potential hazards. Resin hemoperfusion should be first considered for acute CBZ intoxication, especially when drug-induced gastrointestinal hypomotility prevents elimination via the gut and patient is under life-threatening condition.
Li
Tie Gang
TG
Emergency Department, Shengjing Hospital of China Medical University, Shenyang 110004, China. litg@sj-hospital.org
Yan
Yong
Y
Wang
Na Na
NN
Zhao
Min
M
D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D002220:Carbamazepine / Q000097:blood / Q000506:poisoning*; D004636:Emergency Service, Hospital; D015600:Glasgow Coma Scale; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000927:Anticonvulsants; D002220:Carbamazepine