Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis.
Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria, where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress, including sepsis, in which antioxidants targeted at mitochondria have shown promise, and the future implications for such approaches in patients.
Galley
Helen F
HF
Academic Unit of Anaesthesia & Intensive Care, School of Medicine & Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, UK. h.f.galley@abdn.ac.uk
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species
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