Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers.
The influence of the poly(D,L-lactic acid) (PDLLA) coating thickness on the in vitro vancomycin release from a hydroxyapatite (HA) carrier was studied. Microporous HA fibers with a porosity of 51 v% and an average pore diameter of 1.0 μm were fabricated by a diffusion-induced phase separation technique. They were loaded with 38 mg vancomycin hydrochloride (VH)/gHA, and their cylindrical shape enabled the application of the spray coating technique for the deposition of uniform PDLLA coating thicknesses, varying from 6.5 μm to 28 μm. The resulting in vitro VH release varied from a complete release within 14 days for 6.5 μm coatings to a release of 23% after 28 days for 28 μm coatings. It was clear that the VH release rate from a HA fiber can be adjusted by varying the PDLLA coating thickness. Microbiological tests of these fibers against a methicillin-resistant Staphylococcus aureus (MRSA) isolate pointed to the importance of the initial burst release and confirmed that the released antibiotics had the potential to interfere with S. aureus biofilm formation.
Ravelingien
Matthieu
M
Materials Technology, VITO NV, Mol, Belgium. matthieu.ravelingien@telenet.be
Mullens
Steven
S
Luyten
Jan
J
D'Hondt
Matthias
M
Boonen
Jente
J
De Spiegeleer
Bart
B
Coenye
Tom
T
Vervaet
Chris
C
Remon
Jean Paul
JP
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D014640:Vancomycin / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D014640:Vancomycin; D017886:Durapatite