Hemodynamic effects of stenting on wide-necked intracranial aneurysms.
BACKGROUND
Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.


METHODS
Three idealized plexiglass aneurismal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics (CFD) simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.


RESULTS
The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac. Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.


CONCLUSIONS
Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.
Zhang
Yi-sen
YS
Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
Yang
Xin-jian
XJ
Wang
Sheng-zhang
SZ
Qiao
Ai-ke
AK
Chen
Jia-liang
JL
Zhang
Kun-ya
KY
Liu
Zhi-cheng
ZC
Zhao
Yu-jing
YJ
Zhang
Ying
Y
Luo
Bin
B
Li
Chuan-hui
CH
D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D057446:Hydrodynamics; D002532:Intracranial Aneurysm / Q000628:therapy*; D015607:Stents