The utility of single-channel nasal airflow pressure transducer in the diagnosis of OSA at home.
BACKGROUND
Given the high prevalence of obstructive sleep apnea (OSA) and the demand on polysomnography (PSG), there is a need for low cost accurate simple diagnostic modalities that can be easily deployed in primary care to improve access to diagnosis.


OBJECTIVE
The aim was to examine the utility of single-channel nasal airflow monitoring using a pressure transducer at home in patients with suspected OSA.


METHODS
Cross-sectional study


METHODS
Laboratory and home


METHODS
The study was conducted in two populations. Consecutive patients with suspected OSA were recruited from the sleep disorders clinic at a tertiary referral center and from 6 local metropolitan primary care centers.


METHODS
All patients answered questionnaires and had laboratory PSG. Nasal airflow was monitored for 3 consecutive nights at home in random order either before or after PSG.


RESULTS
Atotal of 193 patients participated (105 sleep clinic patients and 88 from primary care). The mean bias PSG apnea hypopnea index (AHI) minus nasal flow respiratory disturbance index (NF RDI) was -4.9 events per hour with limits of agreement (2 SD) of 27.8. NF RDI monitored over 3 nights had high accuracy for diagnosing both severe OSA (defined as PSG AHI > 30 events per hour) with area under the receiver operating characteristic curve (AUC) 0.92 (95% confidence interval (CI) 0.88-0.96) and any OSA (PSG AHI > 5), AUC 0.87 (95% CI 0.80-0.94).


CONCLUSIONS
Single-channel nasal airflow can be implemented as an accurate diagnostic tool for OSA at home in both primary care and sleep clinic populations.
Rofail
Lydia Makarie
LM
National Health Medical Research Council Centre for Clinical Research Excellence in Respiratory and Sleep Medicine, Australia. lydiamr@woolcock.org.au
Wong
Keith K H
KK
Unger
Gunnar
G
Marks
Guy B
GB
Grunstein
Ronald R
RR
D000328:Adult; D000465:Algorithms; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D017286:Polysomnography / Q000295:instrumentation*; D011320:Primary Health Care; D025363:Rhinomanometry / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis*; D014160:Transducers, Pressure
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