title: Mediterranean dietary patterns and prospective weight change in participants of the EPIC-PANACEA project.
abstract: BACKGROUND
  There is an association between a greater adherence to a Mediterranean diet and a reduced risk of developing chronic diseases. However, it is not clear whether this dietary pattern may be protective also against the development of obesity.
  
  
  OBJECTIVE
  We assessed the association between the adherence to the Mediterranean dietary pattern (MDP), prospective weight change, and the incidence of overweight or obesity.
  
  
  METHODS
  We conducted a prospective cohort study [the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol Consumption, Cessation of Smoking, Eating Out of Home, and Obesity (EPIC-PANACEA) project] in 373,803 individuals (103,455 men and 270,348 women; age range: 25-70 y) from 10 European countries. Anthropometric measurements were obtained at recruitment and after a median follow-up time of 5 y. The relative Mediterranean Diet Score (rMED; score range: 0-18) was used to assess adherence to the MDP according to the consumption of 9 dietary components that are characteristic of the Mediterranean diet. The association between the rMED and 5-y weight change was modeled through multiadjusted mixed-effects linear regression.
  
  
  RESULTS
  Individuals with a high adherence to the MDP according to the rMED (11-18 points) showed a 5-y weight change of -0.16 kg (95% CI: -0.24, -0.07 kg) and were 10% (95% CI: 4%, 18%) less likely to develop overweight or obesity than were individuals with a low adherence to the MDP (0-6 points). The low meat content of the Mediterranean diet seemed to account for most of its positive effect against weight gain.
  
  
  CONCLUSIONS
  This study shows that promoting the MDP as a model of healthy eating may help to prevent weight gain and the development of obesity.
authors.affiliation: Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. d.romaguera-bosch@imperial.ac.uk
authors.forename: Dora
authors.initials: D
authors.lastname: Romaguera
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Vergnaud
authors.forename: Traci
authors.initials: T
authors.lastname: Mouw
authors.forename: Anne M
authors.initials: AM
authors.lastname: May
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: Genevieve
authors.initials: G
authors.lastname: Buckland
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Couto
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Vanessa
authors.initials: V
authors.lastname: Cottet
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.forename: Birgit
authors.initials: B
authors.lastname: Teucher
authors.forename: Manuela
authors.initials: M
authors.lastname: Bergmann
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Jytte
authors.initials: J
authors.lastname: Halkjaer
authors.forename: Marianne Uhre
authors.initials: MU
authors.lastname: Jakobsen
authors.forename: Christina C
authors.initials: CC
authors.lastname: Dahm
authors.forename: Noemie
authors.initials: N
authors.lastname: Travier
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodriguez
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Sanchez
authors.forename: Pilar
authors.initials: P
authors.lastname: Amiano
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: José María
authors.initials: JM
authors.lastname: Huerta
authors.forename: Jian'an
authors.initials: J
authors.lastname: Luan
authors.forename: Nick
authors.initials: N
authors.lastname: Wareham
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Spencer
authors.forename: Philippos
authors.initials: P
authors.lastname: Orfanos
authors.forename: Androniki
authors.initials: A
authors.lastname: Naska
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Claudia
authors.initials: C
authors.lastname: Agnoli
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Frederike L
authors.initials: FL
authors.lastname: Büchner
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Elisabet
authors.initials: E
authors.lastname: Wirfält
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Johansson
authors.forename: Veronica
authors.initials: V
authors.lastname: Hellstrom
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Toni
authors.initials: T
authors.lastname: Braaten
authors.forename: Dagrun
authors.initials: D
authors.lastname: Engeset
authors.forename: Andreani
authors.initials: A
authors.lastname: Odysseos
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Petra Hm
authors.initials: PH
authors.lastname: Peeters
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D015331:Cohort Studies; D038441:Diet, Mediterranean; D004522:Educational Status; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000453:epidemiology / Q000517:prevention & control*; D050177:Overweight / Q000453:epidemiology / Q000517:prevention & control*; D010349:Patient Compliance; D011336:Probability; D011446:Prospective Studies; D013851:Thinness / Q000453:epidemiology; D013997:Time Factors