title: Uptake and elimination of perfluorinated phosphonic acids in the rat.
abstract: The mono- and di-substituted perfluorinated phosphonic acids (mono-PFPAs and di-PFPAs) are high production volume fluorinated surfactants. Mono-PFPAs have been observed in Canadian surface waters and wastewater treatment plant (WWTP) effluent. The first observation of the di-PFPAs in the environment is reported here, with the observation of the C6/C6 and C6/C8 di-PFPAs in the National Institute for Standards and Technology (NIST) WWTP sludge standard reference material (SRM) 2781. To characterize the risk associated with human exposure to the mono-PFPAs and di-PFPAs, we determined uptake and elimination parameters in the rat. After oral gavage all of the mono-PFPA and di-PFPA congeners were observed in the blood of the dosed animals. Half-lives after intraperitoneal dosing ranged from 0.96 +/- 0.11 to 2.8 +/- 0.5 days for the mono-PFPAs and 1.8 +/- 0.1 to 9.3 +/- 1.5 days for the di-PFPAs. These half-lives are of similar magnitude to those for perfluorooctane sulfonate (PFOS, 8 to 30 days in male rats) and perfluorooctanoate (PFOA, 6 days in male rats and 1 hour in female rats). Both PFOS and PFOA have human half-lives on the order of years, and so the mono-PFPAs and di-PFPAs may also have significant lifetimes in the human body. The analysis of paired whole blood and plasma samples demonstrated that the mono-PFPAs may bind to blood cells underestimating their concentration in plasma and sera samples. The biological fate of the mono-PFPAs and di-PFPAs determined here suggest there is the potential for human exposure and that if exposure does occur, they may be long-lived in the body.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6 Canada.
authors.forename: Jessica C
authors.initials: JC
authors.lastname: D'eon
authors.forename: Scott A
authors.initials: SA
authors.lastname: Mabury
mesh_terms: D000818:Animals; D004784:Environmental Monitoring; D005260:Female; D054879:Halogenation; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013501:Surface-Active Agents / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D063065:Organophosphonates; D013501:Surface-Active Agents; D014874:Water Pollutants, Chemical