Expanding the biological periodic table.
Metal ions play an indispensable role in biology, enabling enzymes to perform their functions and lending support to the structures of numerous macromolecules. Despite their prevalence and importance, the metalloproteome is still relatively unexplored. Cvetkovic et al. (2010) now describe an approach to identify metalloproteins on a genome-wide scale.
Seravalli
Javier
J
Department of Biochemistry, University of Nebraska-Lincoln, 1901 Vine Street, Lincoln, NE 68588, USA.
Ragsdale
Stephen W
SW
J Biol Chem. 2010 Jan 29;285(5):3393-405
19887375
Acc Chem Res. 2009 Oct 20;42(10):1471-9
19697929
Nature. 2010 Aug 5;466(7307):779-82
20639861
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12081-6
18697928
Biochemistry. 2009 Feb 10;48(5):817-9
19187031