RNA helicases at work: binding and rearranging.
RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of RNA metabolism. These proteins bind or remodel RNA or RNA-protein complexes in an ATP-dependent fashion. How RNA helicases physically perform their cellular tasks has been a longstanding question, but in recent years, intriguing models have started to link structure, mechanism and biological function for some RNA helicases. This review outlines our current view on major structural and mechanistic themes of RNA helicase function, and on emerging physical models for cellular roles of these enzymes.
Jankowsky
Eckhard
E
Center for RNA Molecular Biology & Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. exj13@case.edu
D006801:Humans; D008954:Models, Biological; D012313:RNA / Q000378:metabolism; D020365:RNA Helicases / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
D012313:RNA; D020365:RNA Helicases
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