Viable rat-mouse chimeras: where do we go from here?
In a tour-de-force study, Kobayashi et al. (2010) describe the first viable rat-mouse chimeras and demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation.
Solter
Davor
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Institute of Medical Biology, A*STAR, 138648 Singapore, Republic of Singapore. davor.solter@imb.a-star.edu.sg