title: Cytotoxic tirucallane triterpenoids from Melia azedarach fruits.
abstract: The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-alpha-tigloylmelianol and three known tirucallanes, melianone, 21-beta-acetoxy-melianone, and methyl kulonate. The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
authors.affiliation: Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: Nikoletta G
authors.initials: NG
authors.lastname: Ntalli
authors.forename: Filippo
authors.initials: F
authors.lastname: Cottiglia
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Bueno
authors.forename: Laura E
authors.initials: LE
authors.lastname: Alché
authors.forename: Marco
authors.initials: M
authors.lastname: Leonti
authors.forename: Simona
authors.initials: S
authors.lastname: Vargiu
authors.forename: Ersilia
authors.initials: E
authors.lastname: Bifulco
authors.forename: Urania
authors.initials: U
authors.lastname: Menkissoglu-Spiroudi
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Caboni
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000818:Animals; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D004847:Epithelial Cells / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D031586:Melia azedarach / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry* / Q000633:toxicity; D014431:Tylenchoidea / Q000187:drug effects
chemical_list: D003603:Cytotoxins; D010936:Plant Extracts; D014315:Triterpenes; C514393:tirucallane
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