Effects of glutamine and curcumin on bacterial translocation in jaundiced rats.
OBJECTIVE
To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used.


METHODS
Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, Group I received oral normal saline, Group II received oral glutamine and Group III received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage.


RESULTS
We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy.


CONCLUSIONS
On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice.
Karatepe
Oguzhan
O
Department of Surgery, Okmeydani Education and Research Hospital, Istanbul 34715, Turkey. drkaratepe@yahoo.com
Acet
Ersin
E
Battal
Muharrem
M
Adas
Gokhan
G
Kemik
Ahu
A
Altiok
Merih
M
Kamali
Gulcin
G
Koculu
Safiye
S
Catay
Atahan
A
Kamali
Sedat
S
Karahan
Servet
S
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D005973:Glutamine / Q000494:pharmacology*; D007082:Ileum / Q000473:pathology; D041781:Jaundice, Obstructive / Q000378:metabolism / Q000382:microbiology*; D018384:Oxidative Stress; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D014409:Tumor Necrosis Factor-alpha; D005973:Glutamine; D003474:Curcumin
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