title: Prospective motion correction for single-voxel 1H MR spectroscopy.
abstract: Head motion during (1)H MR spectroscopy acquisitions may compromise the quality and reliability of in vivo metabolite measurements. Therefore, a three-plane image-based motion-tracking module was integrated into a single-voxel (1)H MR spectroscopy (point-resolved spectroscopy) sequence. A series of three orthogonal spiral navigator images was acquired immediately prior to the MR spectroscopy water suppression module in order to estimate head motion. By applying the appropriate rotations and translations, the MR spectroscopy voxel position can be updated such that it remains stationary with respect to the brain. Frequency and phase corrections were applied during postprocessing to reduce line width and restore coherent averaging. Spectra acquired during intentional head motion in 11 volunteers demonstrate reduced lipid contamination and increased spectral reproducibility when motion correction is applied.
authors.affiliation: Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813-2427, USA. brianrk@hawaii.edu
authors.forename: Brian
authors.initials: B
authors.lastname: Keating
authors.forename: Weiran
authors.initials: W
authors.lastname: Deng
authors.forename: J Cooper
authors.initials: JC
authors.lastname: Roddey
authors.forename: Nathan
authors.initials: N
authors.lastname: White
authors.forename: Anders
authors.initials: A
authors.lastname: Dale
authors.forename: V Andrew
authors.initials: VA
authors.lastname: Stenger
authors.forename: Thomas
authors.initials: T
authors.lastname: Ernst
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001704:Biopolymers / Q000032:analysis*; D001923:Brain Chemistry; D019416:Head Movements; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons
chemical_list: D001704:Biopolymers; D011522:Protons
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