title: Circulating LTD4 in patients with hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is a type of inflammation-related cancer that usually follows chronic inflammations. Leukotriene D4 (LTD4) is a potent biologically active arachidonic acid-derived lipid mediator that is intimately involved in inflammations and cancers. Although previous researches found overexpression of LTD4 in several other cancers, the circulating LTD4 level in HCC remains unknown. The aim of this study was to examine concentrations of LTD4 and analyze its roles in HCC. The results showed that remarkably high circulating LTD4 in HCC versus healthy subjects (p < 0.001). The levels of LTD4 were neither associated with parameters expressing tumor burden, such as AFP, nor with inflammation factors AST and γ-GT. In addition, the significant increase of circulating LTD4 levels was obtained in patients with HCC accompanied by chronic hepatitis B (CHB), compared with those patients suffering HCC alone(P < 0.05). Furthermore, although the slightly lower levels of LTD4 were detected in HCC patients with non-metastasis and therapy compared with metastasis and non-therapy, no significant differences were detected. Taken together, the levels of circulating LTD4 are elevated in HCC and it may participate in the pathogenesis of HCC as an inflammatory factor from CHB disease to HCC.
authors.affiliation: Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Dongmei
authors.initials: D
authors.lastname: Guo
authors.forename: Huiyu
authors.initials: H
authors.lastname: Li
authors.forename: Shenghua
authors.initials: S
authors.lastname: Jie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000556:secondary; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017998:Leukotriene D4 / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D017998:Leukotriene D4
references.citation: Blood. 2001 Jun 1;97(11):3433-40
references.pmid: 11369634
references.citation: Science. 2001 Nov 30;294(5548):1871-5
references.pmid: 11729303
references.citation: Eur J Cancer. 2010 Aug;46(12):2178-86
references.pmid: 20413301
references.citation: Liver Int. 2007 Mar;27(2):174-85
references.pmid: 17311611
references.citation: Am J Respir Cell Mol Biol. 1998 Sep;19(3):453-61
references.pmid: 9730873
references.citation: J Biol Chem. 2000 Sep 29;275(39):30531-6
references.pmid: 10851239
references.citation: Gastroenterology. 2000 Oct;119(4):1007-18
references.pmid: 11040187
references.citation: Eur J Biochem. 1992 Oct 1;209(1):281-9
references.pmid: 1327771
references.citation: N Engl J Med. 2007 Nov 1;357(18):1841-54
references.pmid: 17978293
references.citation: J Pharmacol Sci. 2007 Jan;103(1):24-32
references.pmid: 17220595
references.citation: Anticancer Res. 2008 Mar-Apr;28(2A):873-8
references.pmid: 18507031
references.citation: Ugeskr Laeger. 2009 Jan 19;171(4):243-6
references.pmid: 19174041
references.citation: Gastroenterology. 2003 Jan;124(1):57-70
references.pmid: 12512030
references.citation: Science. 1983 May 6;220(4597):568-75
references.pmid: 6301011
references.citation: Hepatology. 2010 Mar;51(3):817-27
references.pmid: 20112424
references.citation: Lancet. 2001 Feb 17;357(9255):539-45
references.pmid: 11229684
references.citation: Ann N Y Acad Sci. 2009 Feb;1155:206-21
references.pmid: 19250206
references.citation: Lab Invest. 2000 Nov;80(11):1617-28
references.pmid: 11092522