title: [Modern views of the role of heparin in hemostasis and regulation of enzymatic and hormonal activities].
abstract: This review is focused on the role of heparin in the maintenance of hematological homeostasis. Description of the main components of the hemostatic system is presented. The mechanism of heparin action as an anticoagulating and fibrinolytic agent are analyzed. A hypothesis is forwarded to explain the role of heparin in animals and humans as a key substance promoting stabilization, regulation and distribution of different active blood components bound into complexes with heparin.
authors.forename: M V
authors.initials: MV
authors.lastname: Kondashevskaia
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis; D006493:Heparin / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D057057:Serine Proteases / Q000502:physiology; D013927:Thrombosis / Q000097:blood; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D001779:Blood Coagulation Factors; D000990:Antithrombin III; D006493:Heparin; D057057:Serine Proteases