TIP39 modulates effects of novelty-induced arousal on memory.
Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide localized to neural circuits subserving emotional processing. Recent work showed that mice with null mutation for the gene coding TIP39 (TIP39-KO mice) display increased susceptibility to environmental provocation. Based on this stressor-dependent phenotype, the neuroanatomical distribution of TIP39, and knowledge that novelty-induced arousal modulates memory functions via noradrenergic activation, we hypothesized that exposure to a novel environment differently affects memory performance of mice with or without TIP39 signaling, potentially by differences in sensitivity of the noradrenergic system. We tested TIP39-KO mice and mice with null mutation of its receptor, the parathyroid hormone 2 receptor (PTH2-R), in tasks of short-term declarative and social memory (object recognition and social recognition tests, respectively), and of working memory (Y-maze test) under conditions of novelty-induced arousal or acclimation to the test conditions. Mice lacking TIP39 signaling showed memory impairment selectively under conditions of novelty-induced arousal. Acute administration of a PTH2-R antagonist in wild-type mice had a similar effect. The restoration of memory functions in TIP39-KO mice after injection of a β-adrenoreceptor-blocker, propranolol, suggested involvement of the noradrenergic system. Collectively, these results suggest that the TIP39/PTH2-R system modulates the effects of novelty exposure on memory performance, potentially by acting on noradrenergic signaling.
Coutellier
L
L
Section on Fundamental Neuroscience, National Institute of Mental Health/National Institutes of Health, Bethesda, MD 20892, USA.
Logemann
A
A
Kuo
J
J
Rusnak
M
M
Usdin
T B
TB
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D005556:Form Perception / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; D044183:Receptor, Parathyroid Hormone, Type 2 / Q000037:antagonists & inhibitors / Q000235:genetics; D021641:Recognition, Psychology / Q000502:physiology; D012919:Social Behavior; D013564:Sympathetic Nervous System / Q000502:physiology; D033921:Vesicular Transport Proteins / Q000235:genetics* / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; D044183:Receptor, Parathyroid Hormone, Type 2; C412229:Tfip11 protein, mouse; D033921:Vesicular Transport Proteins; D011433:Propranolol
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