Skin cancer risk among solid organ recipients: a nationwide cohort study in Denmark.
This study assessed the risk of skin cancer following transplantation of 4 types of solid organs, and the risk of skin cancer in patients with chronic diseases that lead to organ transplantations. A population-based cohort of 5279 Danish patients who underwent heart, lung, renal and liver transplantation, and 77,782 patients with chronic heart, lung, renal and liver diseases during 1977-2006 were included in the study. Linkage to the Danish Cancer Registry allowed complete follow-up for basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated. The SIR for squamous cell carcinoma was highest among heart (SIR = 113; 95% CI: 74-166), then renal (SIR = 81; 95% CI: 68-96), lung (SIR = 65; 95% CI: 28-128) and liver (SIR = 60; 95% CI: 27-113) recipients. SIR for squamous cell carcinoma was 4.8 (95% CI: 2.2-9.0) among renal failure patients, but not greatly elevated among patients with the other chronic diseases studied. Organ transplantation is a risk factor for squamous cell carcinoma, with immunosuppressive treatments being the most likely explanation for the association.
Jensen
Annette Ostergaard
AO
Department of Clinical Epidemiology, Aarhus University Hospital, Dernmark. aoj@dce.au.dk
Svaerke
Claus
C
Farkas
Dora
D
Pedersen
Lars
L
Kragballe
Knud
K
Sørensen
Henrik Toft
HT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006331:Heart Diseases / Q000453:epidemiology; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000453:epidemiology; D016030:Kidney Transplantation / Q000009:adverse effects; D008107:Liver Diseases / Q000453:epidemiology; D016031:Liver Transplantation / Q000009:adverse effects; D008171:Lung Diseases / Q000453:epidemiology; D016040:Lung Transplantation / Q000009:adverse effects; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D055815:Young Adult
D007166:Immunosuppressive Agents