Tobacco dependence, the insular cortex and the hypocretin connection.
Tobacco use is a major cause of disease and premature death in the United States. Nicotine is considered the key component of tobacco responsible for addiction in human smokers. Accumulating evidence supports an important role for the hypocretin (orexin) neuropeptide system in regulating the reinforcing properties of most major drugs of abuse, including nicotine. Here, data showing that nicotine activates hypocretin-producing neurons in the lateral hypothalamus, and that disruption of hypocretin transmission decreases nicotine self-administration behavior in rats will be reviewed. Recent findings suggesting that plasma hypocretin levels may be related to the magnitude of cigarette craving in abstinent smokers will be discussed. Finally, the data suggesting that hypocretin transmission in the insular cortex may play an important role in regulating nicotine self-administration behavior in rats will be reviewed. This latter finding may provide mechanistic insight into the apparent disruption of tobacco addiction reported in human smokers with stroke-associated damage to the insular cortex.
Kenny
Paul J
PJ
Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. pjkenny@scripps.edu
D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood* / Q000502:physiology; D009479:Neuropeptides / Q000097:blood* / Q000502:physiology; D000068797:Orexins; D051381:Rats; D014029:Tobacco Use Disorder / Q000097:blood*
D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19480-5
19033203
Eur J Neurosci. 2006 Dec;24(11):3285-98
17156389
J Neuroendocrinol. 2001 May;13(5):421-4
11328451
Neuroscience. 2005;130(2):541-7
15664710
Neuropsychopharmacology. 2006 Feb;31(2):384-95
15988471
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8733-8
8710940
J Pharmacol Exp Ther. 1994 Oct;271(1):294-301
7965727
Genes Dev. 2007 Nov 15;21(22):2995-3005
18006690
Neuron. 2003 Sep 25;40(1):139-50
14527439
Nature. 2005 Sep 22;437(7058):556-9
16100511
Pharmacol Biochem Behav. 1992 Apr;41(4):755-9
1594644
Alcohol. 2009 Sep;43(6):433-41
19801273
Neuron. 2000 Aug;27(2):349-57
10985354
Science. 2007 Oct 26;318(5850):655-8
17962567
J Comp Neurol. 2003 Sep 15;464(2):220-37
12898614
Hypertension. 2001 Jun;37(6):1382-7
11408381
Psychopharmacology (Berl). 2003 Mar;166(3):306-13
12569428
Neuroscience. 2008 Feb 6;151(3):659-70
18164822
Brain Res. 2010 Feb 16;1314:139-44
19891960
J Pharmacol Exp Ther. 2000 Aug;294(2):458-65
10900219
Addict Biol. 2009 Jan;14(1):32-42
18855804
Synapse. 2000 Oct;38(1):1-9
10941135
Neuropsychopharmacology. 2009 Jan;34(2):266-81
18418357
Psychopharmacology (Berl). 2009 Sep;206(1):23-37
19529922
J Neurosci. 2005 Dec 14;25(50):11757-67
16354934
Neuropsychopharmacology. 2009 Aug;34(9):2125-34
19322167
J Neurosci. 2006 May 31;26(22):5894-900
16738231
Brain Res. 2010 Feb 16;1314:124-9
19646424
Psychopharmacology (Berl). 2005 Oct;182(1):75-83
16075284
Nat Rev Neurosci. 2002 May;3(5):339-49
11988773
J Neurosci. 2002 Aug 1;22(15):6742-6
12151553
Br J Pharmacol. 2001 Dec;134(7):1461-6
11724752
Behav Neurosci. 2009 Aug;123(4):810-4
19634939
Behav Brain Res. 2005 Feb 28;157(2):331-41
15639184
Mol Neurobiol. 2005 Dec;32(3):285-94
16385142
J Comp Neurol. 2006 Feb 10;494(5):845-61
16374809
Psychopharmacology (Berl). 2008 Jul;199(1):109-17
18470506
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73
16357203
Psychopharmacology (Berl). 1995 Jan;117(1):2-10; discussion 14-20
7724697
Psychopharmacology (Berl). 1992;107(2-3):285-9
1615127
J Neurosci. 2005 May 25;25(21):5225-9
15917462
Neuroscience. 1987 Aug;22(2):425-39
2823173
Psychopharmacology (Berl). 2010 Apr;209(2):203-12
20177882
J Neurosci. 2004 Dec 15;24(50):11439-48
15601950
Cell. 1999 Aug 6;98(3):365-76
10458611
Science. 2007 Jan 26;315(5811):531-4
17255515
J Neurosci. 2006 Jan 11;26(2):398-405
16407535
Physiol Behav. 2008 Mar 18;93(4-5):947-51
18262574
J Pharmacol Exp Ther. 2007 Dec;323(3):805-12
17878407
Biochem Biophys Res Commun. 1999 Jan 27;254(3):623-7
9920789
Endocrine. 2006 Aug;30(1):75-9
17185795
Eur J Neurosci. 2001 Apr;13(7):1444-52
11298806
Value Health. 2010 Mar-Apr;13(2):209-14
19912599
Neurochem Int. 2010 Jan;56(1):11-5
19737591
Psychopharmacology (Berl). 2002 Feb;160(1):56-66
11862374
J Neurosci. 2004 Aug 25;24(34):7421-6
15329388
Neuropsychopharmacology. 2003 Feb;28(2):216-25
12589374
Neurosci Lett. 1986 Dec 23;72(3):330-4
3822236
Neuron. 2007 Apr 19;54(2):183-6
17442239
J Neurosci. 2006 Jan 18;26(3):723-30
16421292
Neuroreport. 2001 Jul 3;12(9):1885-9
11435917
Br J Pharmacol. 2008 May;154(2):406-16
18223663
Nat Neurosci. 2004 Jun;7(6):583-4
15146188
Biol Psychiatry. 2010 Apr 15;67(8):753-60
20189166
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
9419374
Biochem Biophys Res Commun. 2000 Apr 2;270(1):318-23
10733946
J Neurosci. 2005 Jun 1;25(22):5389-96
15930388
Alcohol Clin Exp Res. 2007 Nov;31(11):1858-65
17850217
Nature. 2005 Jul 7;436(7047):103-7
16001069
Brain Res. 2010 Mar 4;1317:24-32
20034477
J Neurosci. 2006 Sep 27;26(39):10043-50
17005867
Brain Res. 1999 May 8;827(1-2):243-60
10320718
Peptides. 2001 Dec;22(12):2175-9
11786207
Drug News Perspect. 2005 May;18(4):250-5
16034481
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2035-40
11172071
Trends Pharmacol Sci. 2007 Mar;28(3):135-41
17276521
Brain Res. 1986 Jun 4;375(1):182-5
3719356
Eur J Neurosci. 2008 Oct;28(8):1629-40
18973582
MMWR Morb Mortal Wkly Rep. 2007 Nov 9;56(44):1157-61
17989644
Biol Psychiatry. 2008 Aug 1;64(3):175-83
18423425
J Int Med Res. 2009 Mar-Apr;37(2):331-40
19383226
Neuropharmacology. 2009;56 Suppl 1:112-21
18655797
Neurosci Lett. 2001 Jan 26;298(1):1-4
11154821
J Neurosci. 2007 Apr 25;27(17):4587-97
17460071
Behav Brain Res. 2007 Oct 1;183(1):43-51
17599478
Neuropharmacology. 2006 Jun;50(8):1030-40
16580026
J Neuroendocrinol. 2001 Jun;13(6):561-6
11412343
J Neurosci. 2007 Mar 14;27(11):2837-45
17360905
Psychopharmacology (Berl). 2008 Sep;200(1):81-91
18584153
Eur J Neurosci. 2009 Aug;30(3):493-503
19656173
Trends Neurosci. 2009 Jan;32(1):56-67
18986715
J Neurosci. 2010 Feb 10;30(6):2300-10
20147556
Brain Res. 2010 Feb 16;1314:74-90
19815001
Eur J Neurosci. 2005 Jun;21(11):2993-3001
15978010
Cell. 1998 Feb 20;92(4):573-85
9491897
Nat Neurosci. 2000 Oct;3(10):1049-56
11017179
Eur J Pharmacol. 2006 Mar 27;535(1-3):172-6
16545369
Neuroreport. 2001 Apr 17;12(5):993-7
11303775
Cell. 1999 Aug 20;98(4):437-51
10481909
Biol Psychiatry. 2008 Jan 15;63(2):152-7
17570346
Nature. 2007 Nov 15;450(7168):420-4
17943086
Alcohol. 2009 Aug;43(5):379-86
19671464
Brain Res Bull. 2008 Dec 16;77(6):367-73
18950690
J Neurosci. 2007 Oct 10;27(41):11075-82
17928449
Physiol Behav. 2004 Mar;81(1):129-40
15059692
Brain Res. 1999 Dec 4;849(1-2):248-52
10592311
Neuron. 2003 Jun 5;38(5):701-13
12797956
Psychoneuroendocrinology. 2010 May;35(4):570-7
19828259
Behav Brain Res. 2005 May 7;160(1):11-24
15836896
J Neurosci. 2009 Sep 9;29(36):11215-25
19741128
Eur Neuropsychopharmacol. 2007 Sep;17(9):573-9
17346943
Neuron. 2006 Feb 16;49(4):589-601
16476667
Trends Cogn Sci. 2009 Sep;13(9):372-80
19716751
J Neurosci. 2007 Dec 19;27(51):14035-40
18094242
J Neurosci. 1998 Dec 1;18(23):9996-10015
9822755
Brain Res. 1999 Mar 13;821(2):526-9
10064841
Brain Res. 1994 Aug 8;653(1-2):278-84
7982062
Nat Med. 2010 Jan;16(1):111-5
20037593
Eur J Neurosci. 2010 Jan;31(2):336-48
20039943
J Appl Physiol (1985). 2005 Apr;98(4):1387-95
15557013
Neuroscience. 2006 Nov 17;143(1):25-38
16949214
Psychopharmacology (Berl). 2003 Aug;169(1):68-76
12774186
Brain. 2001 Sep;124(Pt 9):1720-33
11522575
Cell Metab. 2009 Jan 7;9(1):64-76
19117547
J Neurosci. 2008 Mar 19;28(12):3071-5
18354010
Neuroscience. 2008 Dec 10;157(4):720-32
18952152
Endocrinology. 2000 Oct;141(10):3623-9
11014216
Circulation. 1998 Aug 11;98(6):528-34
9714109
Eur J Neurosci. 2001 Oct;14(7):1075-81
11683899
Life Sci. 2003 Jun 27;73(6):759-68
12801597
Cereb Cortex. 2010 Jul;20(7):1756-67
19915095
Peptides. 2005 Nov;26(11):2331-8
15893404
Endocrinology. 2002 Aug;143(8):2995-3000
12130565
Pharmacol Biochem Behav. 2009 Nov;94(1):1-7
19698739
Br J Pharmacol. 2006 Jul;148(6):752-9
16751790
J Neurosci. 2000 Dec 1;20(23):8954-64
11102506
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):748-53
9892705
Neuropsychopharmacology. 2006 Jun;31(6):1203-11
16192981
Neuropharmacology. 2010 Jan;58(1):185-94
19596018
Neuropharmacology. 2010 Jan;58(1):179-84
19591850
J Neurosci. 2003 Apr 15;23(8):3106-11
12716916
Biol Psychiatry. 2009 May 15;65(10):857-62
19251246