Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes.
OBJECTIVE
Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain.


METHODS
Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping.


CONCLUSIONS
Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.
Kocabas
Neslihan Aygun
NA
Fonds de la Recherche Scientifique (FNRS), Laboratoire de Neurologie Expérimentale, Université Libre de Bruxelles, Belgium. naygunko@ulb.ac.be
Antonijevic
Irina
I
Faghel
Carole
C
Forray
Carlos
C
Kasper
Siegfried
S
Lecrubier
Yves
Y
Linotte
Sylvie
S
Massat
Isabelle
I
Montgomery
Stuart
S
Noro
Magali
M
Oswald
Pierre
P
Snyder
Lenore
L
Souery
Daniel
D
Zohar
Joseph
J
Mendlewicz
Julien
J
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D059020:Suicidal Ideation
D000928:Antidepressive Agents; D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins