title: Contributions of studies on alcohol use disorders to understanding cerebellar function.
abstract: Neuropathological, neuropsychological, and neuroimaging studies of human alcoholism provide evidence for degradation of frontal, pontine, thalamic, and cerebellar brain sites and disturbed associated functions. Current studies using neuroimaging combined with examination of executive functions, traditionally considered the sole purview of the frontal lobes, have identified a role for the cerebellum serving as a compensatory processing adjunct to enable normal performance on challenging tasks tapping executive functions. This overview proposes that disruption of an executive frontocerebellar network is a major contributor to characteristic behaviors of alcoholism that, on the one hand, enable alcohol use disorders, and on the other hand, lead to compensation for dysfunctions in alcoholism traditionally considered frontally-based.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA.
authors.forename: Natalie M
authors.initials: NM
authors.lastname: Zahr
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Pitel
authors.forename: Sandra
authors.initials: S
authors.lastname: Chanraud
authors.forename: Edith V
authors.initials: EV
authors.lastname: Sullivan
mesh_terms: D000437:Alcoholism / Q000473:pathology* / Q000503:physiopathology*; D000818:Animals; D001931:Brain Mapping; D002531:Cerebellum / Q000473:pathology / Q000502:physiology*; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans
references.citation: J Neurol Sci. 1997 Jul;149(1):27-35
references.pmid: 9168162
references.citation: Psychiatry Res. 2009 Jul 15;173(1):22-30
references.pmid: 19442492
references.citation: Brain. 2000 Jan;123 ( Pt 1):141-54
references.pmid: 10611128
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):919-27
references.pmid: 12369267
references.citation: Alcohol Clin Exp Res. 2003 Sep;27(9):1409-19
references.pmid: 14506401
references.citation: J Chromatogr B Biomed Appl. 1996 Jun 7;681(2):213-8
references.pmid: 8811429
references.citation: Alcohol Clin Exp Res. 2000 May;24(5):611-21
references.pmid: 10832902
references.citation: Neuroimage. 2001 Sep;14(3):723-35
references.pmid: 11506544
references.citation: J Cogn Neurosci. 2002 Apr 1;14(3):493-9
references.pmid: 11970808
references.citation: Neuropsychol Rev. 2007 Sep;17(3):239-57
references.pmid: 17874302
references.citation: Biol Psychiatry. 1998 Jan 15;43(2):118-31
references.pmid: 9474444
references.citation: Brain. 1987 Apr;110 ( Pt 2):301-14
references.pmid: 3567526
references.citation: Neuron. 2004 Mar 4;41(5):825-37
references.pmid: 15003180
references.citation: AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1926-32
references.pmid: 11733327
references.citation: J Neurosci. 1997 Dec 15;17(24):9675-85
references.pmid: 9391022
references.citation: J Neurol Neurosurg Psychiatry. 1985 Mar;48(3):211-7
references.pmid: 3981189
references.citation: BMJ. 1994 Jun 25;308(6945):1663-7
references.pmid: 8025457
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):951-61
references.pmid: 14499312
references.citation: J Neuropathol Exp Neurol. 1993 Nov;52(6):567-79
references.pmid: 8229075
references.citation: Alcohol Clin Exp Res. 2010 Jul;34(7):1201-11
references.pmid: 20477772
references.citation: Alcohol Clin Exp Res. 2000 Aug;24(8):1214-21
references.pmid: 10968660
references.citation: Neuroimage. 2001 Jul;14(1 Pt 1):7-20
references.pmid: 11525339
references.citation: Histol Histopathol. 1995 Jul;10(3):633-8
references.pmid: 7579811
references.citation: Biol Psychiatry. 1995 Feb 1;37(3):170-4
references.pmid: 7727625
references.citation: Cortex. 2011 Jan;47(1):137-44
references.pmid: 19786276
references.citation: Neuropsychopharmacology. 2009 Apr;34(5):1223-32
references.pmid: 18615012
references.citation: Neuropsychol Rev. 2010 Sep;20(3):271-9
references.pmid: 20563894
references.citation: Alcohol Alcohol Suppl. 1991;1:375-80
references.pmid: 1845566
references.citation: Alcohol Clin Exp Res. 1995 Aug;19(4):1078-82
references.pmid: 7485820
references.citation: Am J Psychiatry. 2003 Jun;160(6):1180-3
references.pmid: 12777281
references.citation: Neuroimage. 2002 Mar;15(3):708-18
references.pmid: 11848714
references.citation: Brain. 2007 Jan;130(Pt 1):36-47
references.pmid: 17178742
references.citation: Neuroscience. 1999;91(2):429-38
references.pmid: 10366000
references.citation: Eur J Neurosci. 2003 Jun;17(11):2388-400
references.pmid: 12814370
references.citation: J Neurosci. 2007 Feb 28;27(9):2349-56
references.pmid: 17329432
references.citation: Eur Biophys J. 2010 Mar;39(4):527-40
references.pmid: 19680645
references.citation: Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):104S-109S
references.pmid: 11391058
references.citation: Neurology. 1995 Jul;45(7):1384-91
references.pmid: 7617201
references.citation: Nat Rev Neurosci. 2003 Jun;4(6):469-80
references.pmid: 12778119
references.citation: Neuroimage. 2006 Sep;32(3):1195-204
references.pmid: 16797189
references.citation: Alcohol Clin Exp Res. 2010 Jun;34(6):1098-109
references.pmid: 20374203
references.citation: J Comp Neurol. 1989 Nov 1;289(1):53-73
references.pmid: 2478597
references.citation: Alcohol Clin Exp Res. 2001 Jun;25(6):924-34
references.pmid: 11410730
references.citation: J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):124-7
references.pmid: 3351512
references.citation: Alcohol Health Res World. 1997;21(1):65-75
references.pmid: 15706764
references.citation: Psychopharmacology (Berl). 2010 Feb;208(2):279-90
references.pmid: 19943036
references.citation: Cereb Cortex. 2006 Jul;16(7):1030-9
references.pmid: 16207932
references.citation: Neurology. 1992 Aug;42(8):1493-6
references.pmid: 1641142
references.citation: Neuropsychology. 2000 Jul;14(3):341-52
references.pmid: 10928737
references.citation: J Magn Reson B. 1996 Jun;111(3):209-19
references.pmid: 8661285
references.citation: Radiology. 1993 Jan;186(1):59-65
references.pmid: 8416587
references.citation: J Neurosci. 2003 Sep 10;23(23):8432-44
references.pmid: 12968006
references.citation: Alcohol Clin Exp Res. 2002 Sep;26(9):1368-80
references.pmid: 12351932
references.citation: Magn Reson Med. 2003 May;49(5):953-61
references.pmid: 12704779
references.citation: Alcohol Res Health. 2010;33(1-2):127-43
references.pmid: 23579943
references.citation: J Neurosci. 1989 Feb;9(2):582-7
references.pmid: 2521896
references.citation: Neuroimage. 2005 May 15;26(1):132-40
references.pmid: 15862213
references.citation: Alcohol Clin Exp Res. 2004 Dec;28(12):1849-60
references.pmid: 15608601
references.citation: Neurosci Biobehav Rev. 2008;32(3):466-85
references.pmid: 17919727
references.citation: Am J Psychiatry. 2003 Jun;160(6):1110-6
references.pmid: 12777269
references.citation: Neuropsychopharmacology. 2007 Feb;32(2):429-38
references.pmid: 17047671
references.citation: Ann Neurol. 1993 Oct;34(4):594-602
references.pmid: 8215247
references.citation: Arch Neurol. 1993 Aug;50(8):873-80
references.pmid: 8352676
references.citation: Alcohol. 1992 May-Jun;9(3):247-55
references.pmid: 1605892
references.citation: Neuroimage. 2006 Jul 15;31(4):1487-505
references.pmid: 16624579
references.citation: Neuroimage. 2007 Feb 1;34(3):879-87
references.pmid: 17127079
references.citation: Addict Biol. 2007 Mar;12(1):122-32
references.pmid: 17407506
references.citation: Lancet. 1993 Nov 13;342(8881):1201-4
references.pmid: 7901529
references.citation: Hepatology. 1997 Oct;26(4):837-41
references.pmid: 9328301
references.citation: Magn Reson Med. 1995 Oct;34(4):537-41
references.pmid: 8524021
references.citation: Cortex. 2008 Sep;44(8):1037-66
references.pmid: 18614161
references.citation: Neuropsychol Rev. 2010 Sep;20(3):261-70
references.pmid: 20811947
references.citation: J Neurosci. 1993 Mar;13(3):981-9
references.pmid: 8441018
references.citation: Alcohol. 2004 Jan;32(1):63-7
references.pmid: 15066705
references.citation: Brain Cogn. 1997 Jul;34(2):218-45
references.pmid: 9220087
references.citation: J Neurosci. 2010 Sep 8;30(36):12168-78
references.pmid: 20826679
references.citation: J Neuropathol Exp Neurol. 1998 Feb;57(2):101-10
references.pmid: 9600202
references.citation: Brain Res. 1994 Jul 4;650(1):1-8
references.pmid: 7953660
references.citation: Biol Psychiatry. 2000 Aug 15;48(4):276-86
references.pmid: 10960158
references.citation: Br Med J (Clin Res Ed). 1985 Feb 16;290(6467):501-4
references.pmid: 3918649
references.citation: Acta Neuropathol. 1989;79(2):200-4
references.pmid: 2596268
references.citation: Alcohol Clin Exp Res. 2001 Feb;25(2):236-45
references.pmid: 11236838
references.citation: J Stud Alcohol Drugs. 2010 Mar;71(2):278-89
references.pmid: 20230726
references.citation: Psychiatry Res. 2001 Nov 5;108(1):49-55
references.pmid: 11677067
references.citation: Biol Psychiatry. 2006 Feb 15;59(4):364-72
references.pmid: 16125148
references.citation: Neuroimage. 2002 Nov;17(3):1131-43
references.pmid: 12414255
references.citation: Psychopharmacology (Berl). 2005 Aug;180(4):583-94
references.pmid: 15834536
references.citation: J Magn Reson Imaging. 2003 Oct;18(4):427-33
references.pmid: 14508779
references.citation: Alcohol Clin Exp Res. 2005 Sep;29(9):1698-705
references.pmid: 16205370
references.citation: Alcohol Clin Exp Res. 2004 Apr;28(4):650-61
references.pmid: 15100618
references.citation: Acta Psychiatr Scand Suppl. 1999;395:51-7
references.pmid: 10225333
references.citation: Magn Reson Imaging. 1996;14(5):553-7
references.pmid: 8843367
references.citation: Hum Brain Mapp. 2010 May;31(5):798-819
references.pmid: 20017133
references.citation: Magn Reson Imaging. 1995;13(8):1197-211
references.pmid: 8750337
references.citation: Hum Brain Mapp. 2009 Apr;30(4):1374-86
references.pmid: 18537110
references.citation: Alcohol Clin Exp Res. 1994 Feb;18(1):172-6
references.pmid: 8198216
references.citation: Ann Neurol. 2004 Apr;55(4):522-9
references.pmid: 15048891
references.citation: Neuroimage. 2003 Aug;19(4):1510-20
references.pmid: 12948707
references.citation: Neuroimage. 2001 Jun;13(6 Pt 1):1174-85
references.pmid: 11352623
references.citation: Int J Neurol. 1987-1988;21-22:51-7
references.pmid: 2980692
references.citation: Alcohol Clin Exp Res. 2003 Apr;27(4):704-11
references.pmid: 12711934
references.citation: Arch Neurol. 1988 Sep;45(9):990-2
references.pmid: 3415529
references.citation: Alcohol Clin Exp Res. 2001 Aug;25(8):1206-12
references.pmid: 11505052
references.citation: Alcohol Clin Exp Res. 1992 Dec;16(6):1078-89
references.pmid: 1471762
references.citation: Med Hypotheses. 2010 Aug;75(2):266-8
references.pmid: 20303220
references.citation: J Neurosci. 2009 Jul 1;29(26):8586-94
references.pmid: 19571149
references.citation: AMA Arch Neurol Psychiatry. 1959 Feb;81(2):154-72
references.pmid: 13616772
references.citation: Neuropsychopharmacology. 2010 Aug;35(9):1868-78
references.pmid: 20410871
references.citation: Alcohol Clin Exp Res. 2010 Jun;34(6):1045-51
references.pmid: 20374208
references.citation: Biol Psychiatry. 2005 Dec 15;58(12):974-80
references.pmid: 16084857
references.citation: Cereb Cortex. 2009 Oct;19(10):2485-97
references.pmid: 19592571
references.citation: Annu Rev Neurosci. 2009;32:413-34
references.pmid: 19555291
references.citation: Alcohol Clin Exp Res. 2010 Nov;34(11):1888-98
references.pmid: 20735374
references.citation: Int Rev Neurobiol. 1997;41:31-60
references.pmid: 9378595
references.citation: Alcohol Clin Exp Res. 2004 Oct;28(10):1577-86
references.pmid: 15597092
references.citation: Cereb Cortex. 2006 Aug;16(8):1077-86
references.pmid: 16221930
references.citation: Acta Radiol. 1992 May;33(3):201-6
references.pmid: 1591120
references.citation: Magn Reson Med. 2006 Feb;55(2):302-8
references.pmid: 16408263
references.citation: Biol Psychiatry. 2009 Apr 15;65(8):680-90
references.pmid: 19103436
references.citation: Neuroimage. 2002 Nov;17(3):1429-36
references.pmid: 12414282