Débridement of the noninfected wound.
The utility of wound débridement has expanded to include the management of all chronic wounds, even in the absence of infection and gross necrosis. Biofilm, metalloproteases on the wound base, and senescent cells at the wound edge irreversibly change the physiology of wound healing and contribute to a pathologic, chronic inflammatory environment. The objective of this review is to provide surgeons with a baseline understanding of the processes of débridement in the noninfected wound.
Cornell
Rhonda S
RS
Diabetic Limb Salvage, Department of Plastic Surgery, Georgetown University Medical Center, Washington, DC 20007, USA.
Meyr
Andrew J
AJ
Steinberg
John S
JS
Attinger
Christopher E
CE
D000208:Acute Disease; D002908:Chronic Disease; D003646:Debridement / Q000379:methods; D017719:Diabetic Foot / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing; D014946:Wound Infection / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery