title: Age at onset of multiple sclerosis is correlated to use of combined oral contraceptives and childbirth before diagnosis.
abstract: The aim of this study was to evaluate whether age of onset of multiple sclerosis is related to use of combined oral contraceptives and/or timing of childbirth. The results showed that use of combined oral contraceptives and childbirth before the first multiple sclerosis symptom was correlated to a higher mean age at the onset of the disease.
authors.affiliation: Division of Womens and Childrens Health, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. per.holmqvist@lvn.se
authors.forename: Per
authors.initials: P
authors.lastname: Holmqvist
authors.forename: Mats
authors.initials: M
authors.lastname: Hammar
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Landtblom
authors.forename: Jan
authors.initials: J
authors.lastname: Brynhildsen
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D036801:Parturition / Q000502:physiology; D011247:Pregnancy; D012042:Registries; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined