title: [Dry eye syndrome and neurotrophic keratitis in childhood. Causes and therapy].
abstract: OBJECTIVE
  The purpose of this review is to enhance the physician's awareness of dry eye syndrome and neurotrophic keratitis in children, to describe the most frequently associated conditions and to discuss the diagnostic and therapeutic options available.
  
  
  METHODS
  A literature review of the pathogenesis of dry eye syndrome and neurotrophic keratitis in children was carried out, clinical cases from our pediatric ophthalmology office are presented as well as therapeutic strategies.
  
  
  RESULTS
  Diseases of the cornea and ocular surface such as dry eye syndrome, neurotrophic keratitis and corneal ulcers are infrequent in children compared to adults. However, they do occur and should be diagnosed and treated as soon as possible in order to prevent long-term complications and amblyopia.
  
  
  CONCLUSIONS
  Inflammatory diseases of the ocular surface can be easily overlooked in children due to the often unknown spectrum of differential diagnoses and the frequently reduced cooperation during examination of young children. Correct and early diagnosis is essential for prevention of long-term complications, e.g. corneal ulceration and scarring.
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland. tinadie@gmx.net
authors.forename: T
authors.initials: T
authors.lastname: Dietrich
authors.forename: A B
authors.initials: AB
authors.lastname: Renner
authors.forename: H
authors.initials: H
authors.lastname: Helbig
authors.forename: I M
authors.initials: IM
authors.lastname: Oberacher-Velten
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*
chemical_list: D000893:Anti-Inflammatory Agents
references.citation: Eye (Lond). 1996;10 ( Pt 3):355-61
references.pmid: 8796162
references.citation: Ophthalmology. 1999 Jan;106(1):160-4
references.pmid: 9917798
references.citation: Cornea. 2006 Jan;25(1):112-4
references.pmid: 16331052
references.citation: Int J Pediatr Otorhinolaryngol. 2009 Jun;73(6):899-901
references.pmid: 19376597
references.citation: Eur J Ophthalmol. 2007 Nov-Dec;17(6):873-8
references.pmid: 18050110
references.citation: Surv Ophthalmol. 1977 Sep-Oct;22(2):113-9
references.pmid: 918840
references.citation: Aust N Z J Ophthalmol. 1992 Aug;20(3):207-10
references.pmid: 1449772
references.citation: Graefes Arch Clin Exp Ophthalmol. 2004 Jun;242(6):495-500
references.pmid: 14963716
references.citation: Ophthalmology. 2007 Dec;114(12):2271-80
references.pmid: 18054641
references.citation: Eur J Pediatr. 2003 Oct;162(10):661-5
references.pmid: 12898241
references.citation: Acta Ophthalmol Scand. 2007 Nov;85(7):739-44
references.pmid: 17559557
references.citation: Br J Ophthalmol. 1996 Nov;80(11):994-7
references.pmid: 8976728
references.citation: J Interferon Cytokine Res. 2007 Jun;27(6):491-5
references.pmid: 17572013
references.citation: Eur J Ophthalmol. 2008 Jul-Aug;18(4):636-8
references.pmid: 18609489
references.citation: Am J Dis Child. 1983 Mar;137(3):289-90
references.pmid: 6823929
references.citation: Ophthalmologe. 2006 Jan;103(1):18-24
references.pmid: 16362353
references.citation: Cornea. 2007 Feb;26(2):123-9
references.pmid: 17251797
references.citation: Am J Ophthalmol. 2004 Jan;137(1):138-44
references.pmid: 14700657
references.citation: J Pediatr. 2003 Jun;142(6):678-83
references.pmid: 12838197
references.citation: Br J Ophthalmol. 1999 Mar;83(3):323-6
references.pmid: 10365041
references.citation: Cornea. 2009 Apr;28(3):249-53
references.pmid: 19387223
references.citation: Am J Ophthalmol. 2007 Mar;143(3):528-9
references.pmid: 17317407
references.citation: Allergy. 2007 Aug;62(8):917-25
references.pmid: 17620070
references.citation: Surv Ophthalmol. 2007 Jan-Feb;52(1):50-60
references.pmid: 17212990
references.citation: Am J Ophthalmol. 1990 Mar 15;109(3):356-7
references.pmid: 2309873
references.citation: Ophthalmologica. 1977;174(1):20-34
references.pmid: 846696
references.citation: J Pediatr Ophthalmol Strabismus. 2006 Jul-Aug;43(4):236-8
references.pmid: 16915903
references.citation: Ocul Surf. 2008 Jan;6(1):44-51
references.pmid: 18264654
references.citation: Acta Ophthalmol. 2008 May;86(3):253-8
references.pmid: 18093259
references.citation: Cornea. 2007 Sep;26(8):941-4
references.pmid: 17721292
references.citation: Arch Dermatol. 2008 Feb;144(2):167-71
references.pmid: 18283173