title: Small-bowel capsule endoscopy in patients with suspected Crohn's disease-diagnostic value and complications.
abstract: BACKGROUND
  The aim of this work was to assess the value of capsule enteroscopy in the diagnosis of patients with suspected Crohn's Disease (CD). Methods. This was a retrospective study in a single tertiary care centre involving patients undergoing capsule enteroscopy for suspected CD. Patients taking nonsteroidal anti inflammatory drugs during the thirty preceding days or with a follow-up period of less than six months were excluded. Results. Seventy eight patients were included. The endoscopic findings included mucosal breaks in 50%, ulcerated stenosis in 5%, and villous atrophy in 4%. The diagnosis of CD was established in 31 patients. The sensitivity, specificity, positive and negative predictive value of the endoscopic findings were 93%, 80%, 77%, and 94%, respectively. Capsule retention occurred in four patients (5%). The presence of ulcerated stenosis was significantly more frequent in patients with positive inflammatory markers. The diagnostic yield of capsule enteroscopy in patients with negative ileoscopy was 56%, with a diagnostic acuity of 93%.
  
  
  CONCLUSIONS
  Small bowel capsule endoscopy is a safe and valid technique for assessing patients with suspected CD. Capsule retention is more frequent in patients with positive inflammatory markers. Patients with negative ileoscopy and suspected CD should be submitted to capsule enteroscopy.
authors.affiliation: Department of Gastroenterology, University Hospitals of Coimbra, Avenue Bissaya Barreto, 3000-075 Coimbra, Portugal. pedro.n.figueiredo@clix.pt
authors.forename: Pedro
authors.initials: P
authors.lastname: Figueiredo
authors.forename: Nuno
authors.initials: N
authors.lastname: Almeida
authors.forename: Sandra
authors.initials: S
authors.lastname: Lopes
authors.forename: Gabriela
authors.initials: G
authors.lastname: Duque
authors.forename: Paulo
authors.initials: P
authors.lastname: Freire
authors.forename: Clotilde
authors.initials: C
authors.lastname: Lérias
authors.forename: Hermano
authors.initials: H
authors.lastname: Gouveia
authors.forename: Carlos
authors.initials: C
authors.lastname: Sofia
references.citation: Am J Gastroenterol. 2006 Oct;101(10):2218-22
references.pmid: 16848804
references.citation: Endoscopy. 2007 Oct;39(10):895-909
references.pmid: 17968807
references.citation: Endoscopy. 2003 Aug;35(8):688-9
references.pmid: 12929066
references.citation: Gut. 2005 Mar;54(3):369-73
references.pmid: 15710985
references.citation: Endoscopy. 2006 May;38(5):498-502
references.pmid: 16767586
references.citation: Am J Gastroenterol. 2006 Jul;101(7):1484-9
references.pmid: 16863550
references.citation: Gastroenterology. 2005 May;128(5):1172-8
references.pmid: 15887101
references.citation: J Clin Gastroenterol. 2006 Sep;40(8):692-6
references.pmid: 16940880
references.citation: Gut. 2003 Mar;52(3):390-2
references.pmid: 12584221
references.citation: Am J Gastroenterol. 2010 Jun;105(6):1240-8; quiz 1249
references.pmid: 20029412
references.citation: Gastrointest Endosc. 2009 Jan;69(1):74-80
references.pmid: 18691709
references.citation: Endoscopy. 2005 Oct;37(10):1051-4
references.pmid: 16189789
references.citation: Endoscopy. 2009 Jul;41(7):618-37
references.pmid: 19588292
references.citation: Dig Liver Dis. 2007 Feb;39(2):148-54
references.pmid: 17196893
references.citation: World J Gastroenterol. 2004 May 1;10(9):1349-52
references.pmid: 15112357
references.citation: Am J Gastroenterol. 2009 Feb;104(2):465-83; quiz 464, 484
references.pmid: 19174807
references.citation: Clin Gastroenterol Hepatol. 2004 Jan;2(1):31-40
references.pmid: 15017630
references.citation: Clin Gastroenterol Hepatol. 2005 Feb;3(2):133-41
references.pmid: 15704047
references.citation: Clin Gastroenterol Hepatol. 2007 Sep;5(9):1040-5
references.pmid: 17625980
references.citation: Am J Gastroenterol. 2009 Nov;104(11):2734-9
references.pmid: 19584828
references.citation: Gastrointest Endosc. 2008 Jul;68(1):174-80
references.pmid: 18513723
references.citation: Endoscopy. 2003 Jul;35(7):564-8
references.pmid: 12822090
references.citation: Gut. 2006 Mar;55 Suppl 1:i1-15
references.pmid: 16481628
references.citation: Gastrointest Endosc. 2005 Nov;62(5):712-6; quiz 752, 754
references.pmid: 16246685
references.citation: Am J Gastroenterol. 2006 May;101(5):954-64
references.pmid: 16696781
references.citation: J Clin Gastroenterol. 2006 Sep;40(8):688-91
references.pmid: 16940879
references.citation: Dig Liver Dis. 2006 May;38(5):331-5
references.pmid: 16569524