title: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
abstract: We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10⁻⁹; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10⁻⁹). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10⁻¹⁴, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.
authors.affiliation: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kadowaki-3im@h.u-tokyo.ac.jp
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authors.lastname: Kubo
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authors.forename: Masato
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authors.lastname: Iwabu
authors.forename: Nobuhiro
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authors.lastname: Shojima
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Gitte
authors.initials: G
authors.lastname: Andersen
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Witte
authors.forename: Torben
authors.initials: T
authors.lastname: Jørgensen
authors.forename: Torsten
authors.initials: T
authors.lastname: Lauritzen
authors.forename: Annelli
authors.initials: A
authors.lastname: Sandbæk
authors.forename: Torben
authors.initials: T
authors.lastname: Hansen
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ohshige
authors.forename: Shintaro
authors.initials: S
authors.lastname: Omori
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saito
authors.forename: Kohei
authors.initials: K
authors.lastname: Kaku
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirose
authors.forename: Wing-Yee
authors.initials: WY
authors.lastname: So
authors.forename: Delphine
authors.initials: D
authors.lastname: Beury
authors.forename: Juliana C N
authors.initials: JC
authors.lastname: Chan
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: E Shyong
authors.initials: ES
authors.lastname: Tai
authors.forename: Chikako
authors.initials: C
authors.lastname: Ito
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamori
authors.forename: Masato
authors.initials: M
authors.lastname: Kasuga
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D009687:Nuclear Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics*
chemical_list: C494527:C2CD4A protein, human; C494528:C2CD4B protein, human; D009687:Nuclear Proteins; D014157:Transcription Factors; C106347:UBE2E2 protein, human; D044763:Ubiquitin-Conjugating Enzymes
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