Rhodium-catalyzed enantioselective 1,6-addition of arylboronic acids to enynamides: asymmetric synthesis of axially chiral allenylsilanes.
Rhodium-catalyzed asymmetric 1,6-addition of arylboronic acids to β-alkynyl acrylamides substituted with a silyl group on the alkyne terminus took place to give high yields of axially chiral allenylsilanes with 94-99% enantioselectivity, which was realized by use of a rhodium/chiral diene complex.
Nishimura
Takahiro
T
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. tnishi@kuchem.kyoto-u.ac.jp
Makino
Hiroki
H
Nagaosa
Makoto
M
Hayashi
Tamio
T