title: Ocular adnexal mucosa-associated lymphoid tissue lymphoma in Northern China: high frequency of numerical chromosomal changes and no evidence of an association with Chlamydia psittaci.
abstract: Studies from different countries showed variations of genetic changes and association with Chlamydia psittaci in ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. A total of 38 ocular adnexal MALT lymphoma cases from Northern China were studied. Genetic abnormalities were investigated in 28 cases by interphase FISH. C. psittaci and other infectious agents that are commonly-associated with chronic eye disease were screened in 38 cases by PCR. Genetic abnormalities were detected in 60.7% of cases. Among them, only one showed a break-apart of the IgH gene and all others showed numerical abnormalities, including trisomy 18 in 7 cases (25%), 3 copies of BCL6 gene in 12 cases (43%), and 3 copies of C-MYC gene in 2 cases (7%). C. pneumoniae was positive in two cases (5.3%), and C. psittaci, C. trachomatis, HSV1, HSV2, ADV8, and ADV19 were not detected in any cases. In conclusion, numerical abnormalities are frequent and the chromosomal translocations commonly associated with MALT lymphomas are rare in ocular adnexal MALT lymphoma of Northern China. C. psittaci and other infectious agents are not associated with ocular adnexal MALT lymphoma in these patients.
authors.affiliation: Department of Pathology, Capital Medical University, Beijing, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.forename: Lina
authors.initials: L
authors.lastname: Dong
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.forename: Hasi
authors.initials: H
authors.lastname: Jin
authors.forename: Hongtao
authors.initials: H
authors.lastname: Ye
authors.forename: Xiaoge
authors.initials: X
authors.lastname: Zhou
authors.forename: Zifen
authors.initials: Z
authors.lastname: Gao
authors.forename: Gehong
authors.initials: G
authors.lastname: Dong
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zhu
authors.forename: Honggang
authors.initials: H
authors.lastname: Liu
authors.forename: Liping
authors.initials: L
authors.lastname: Gong
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D002691:Chlamydophila psittaci / Q000502:physiology; D002869:Chromosome Aberrations; D005134:Eye Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009956:Psittacosis / Q000150:complications / Q000453:epidemiology*