title: Role of structural MRI in Alzheimer's disease.
abstract: Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.
authors.affiliation: Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA. vemuri.prashanthi@mayo.edu.
authors.forename: Prashanthi
authors.initials: P
authors.lastname: Vemuri
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
references.citation: Ann Neurol. 1991 Oct;30(4):572-80
references.pmid: 1789684
references.citation: Dement Geriatr Cogn Disord. 1999;10 Suppl 1:37-42
references.pmid: 10436338
references.citation: Ann Neurol. 2010 Mar;67(3):317-24
references.pmid: 20373343
references.citation: J Neurosci. 2010 Feb 10;30(6):2088-101
references.pmid: 20147537
references.citation: Neurology. 1999 Apr 12;52(6):1153-8
references.pmid: 10214736
references.citation: Brain. 2008 Mar;131(Pt 3):681-9
references.pmid: 18202106
references.citation: Neuroimage. 2009 Oct 15;48(1):138-49
references.pmid: 19481161
references.citation: N Engl J Med. 2009 May 28;360(22):2302-9
references.pmid: 19474427
references.citation: Neurology. 2009 Jul 28;73(4):287-93
references.pmid: 19636048
references.citation: Neurology. 2004 Mar 23;62(6):925-31
references.pmid: 15037694
references.citation: Neurology. 2005 May 10;64(9):1563-72
references.pmid: 15883317
references.citation: J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):967-72
references.pmid: 1431963
references.citation: Neurobiol Aging. 2006 Mar;27(3):394-401
references.pmid: 16125823
references.citation: J Psychiatry Neurosci. 2009 Mar;34(2):136-42
references.pmid: 19270764
references.citation: Med Image Comput Comput Assist Interv. 2005;8(Pt 1):1-8
references.pmid: 16685822
references.citation: Neurobiol Aging. 2001 Jul-Aug;22(4):529-39
references.pmid: 11445252
references.citation: Neurology. 2010 Jul 13;75(2):143-51
references.pmid: 20625167
references.citation: Ann Neurol. 1997 Jan;41(1):17-24
references.pmid: 9005861
references.citation: Neurology. 2008 Dec 9;71(24):1986-92
references.pmid: 19064880
references.citation: Hippocampus. 2009 Nov;19(11):1055-64
references.pmid: 19309039
references.citation: Eur J Nucl Med Mol Imaging. 2005 Aug;32(8):959-63
references.pmid: 15800784
references.citation: Acta Neuropathol. 1991;82(4):239-59
references.pmid: 1759558
references.citation: J Alzheimers Dis. 2009;16(2):351-62
references.pmid: 19221425
references.citation: J Neurol Neurosurg Psychiatry. 1997 Jun;62(6):596-600
references.pmid: 9219745
references.citation: Ann Neurol. 2006 Jul;60(1):145-7
references.pmid: 16802294
references.citation: Neuroimage. 2009 Apr 15;45(3):645-55
references.pmid: 19280686
references.citation: Am J Psychiatry. 2003 Nov;160(11):2003-11
references.pmid: 14594748
references.citation: J Nucl Med. 2006 Nov;47(11):1778-86
references.pmid: 17079810
references.citation: Neuroimage. 2000 Jun;11(6 Pt 1):805-21
references.pmid: 10860804
references.citation: J Nucl Med. 2007 May;48(5):704-11
references.pmid: 17475957
references.citation: Neurology. 2003 Aug 26;61(4):487-92
references.pmid: 12939422
references.citation: Neurology. 2009 Oct 13;73(15):1186-92
references.pmid: 19726751
references.citation: J Alzheimers Dis. 2008 May;14(1):51-7
references.pmid: 18525127
references.citation: Arch Neurol. 2005 May;62(5):770-3
references.pmid: 15883264
references.citation: Neurobiol Aging. 2011 Dec;32(12):2123-30
references.pmid: 20176414
references.citation: Brain. 2008 Jan;131(Pt 1):60-71
references.pmid: 18063588
references.citation: Lancet Neurol. 2007 Aug;6(8):734-46
references.pmid: 17616482
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4703-7
references.pmid: 11930016
references.citation: J Magn Reson Imaging. 1997 Nov-Dec;7(6):1069-75
references.pmid: 9400851
references.citation: Nat Rev Neurol. 2010 Feb;6(2):67-77
references.pmid: 20139996
references.citation: Neurology. 2003 Jan 28;60(2):253-60
references.pmid: 12552040
references.citation: Brain. 2008 Mar;131(Pt 3):665-80
references.pmid: 18263627
references.citation: Neurology. 2010 Jan 12;74(2):121-7
references.pmid: 20065247
references.citation: Neuroimage. 2009 Mar 1;45(1):215-23
references.pmid: 19056499
references.citation: Am J Psychiatry. 2005 Apr;162(4):676-82
references.pmid: 15800138
references.citation: Brain. 2009 Apr;132(Pt 4):1067-77
references.pmid: 19251758
references.citation: Brain. 2009 May;132(Pt 5):1310-23
references.pmid: 19042931
references.citation: Neurobiol Aging. 2010 May;31(5):758-64
references.pmid: 18692273
references.citation: Br J Radiol. 2007 Dec;80 Spec No 2:S78-91
references.pmid: 18445748
references.citation: AJNR Am J Neuroradiol. 2010 Feb;31(2):347-54
references.pmid: 20075088
references.citation: Psychiatry Res. 2010 Jun 30;182(3):244-50
references.pmid: 20493672
references.citation: Neurosci Lett. 2003 Mar 20;339(2):99-102
references.pmid: 12614904
references.citation: Neurology. 2002 May 28;58(10):1476-82
references.pmid: 12034782
references.citation: Neurology. 2009 Jul 28;73(4):294-301
references.pmid: 19636049
references.citation: Neurology. 1992 Jan;42(1):183-8
references.pmid: 1734300
references.citation: IEEE Trans Med Imaging. 1997 Oct;16(5):623-9
references.pmid: 9368118
references.citation: Neurology. 2002 Mar 12;58(5):750-7
references.pmid: 11889239
references.citation: Eur J Nucl Med Mol Imaging. 2007 Oct;34(10):1658-69
references.pmid: 17520250
references.citation: Neurobiol Aging. 2008 May;29(5):669-75
references.pmid: 17208336
references.citation: Neurocase. 2005 Feb;11(1):8-13
references.pmid: 15804919
references.citation: Ann Neurol. 1990 May;27(5):457-64
references.pmid: 2360787
references.citation: Cereb Cortex. 2010 Sep;20(9):2069-79
references.pmid: 20051356
references.citation: Eur J Nucl Med Mol Imaging. 2006 Jul;33(7):801-9
references.pmid: 16550383
references.citation: Neurology. 2009 Sep 22;73(12):935-40
references.pmid: 19770469
references.citation: Neurology. 2005 Dec 27;65(12):1863-72
references.pmid: 16237129
references.citation: Neuroimage. 2008 Feb 1;39(3):1186-97
references.pmid: 18054253
references.citation: Eur J Nucl Med Mol Imaging. 2010 Jan;37(1):36-45
references.pmid: 19662411
references.citation: Brain. 2009 May;132(Pt 5):1355-65
references.pmid: 19339253
references.citation: Ann Neurol. 2009 Feb;65(2):176-83
references.pmid: 19260027
references.citation: Neuroimage. 2009 Jun;46(2):394-410
references.pmid: 19236926
references.citation: Arch Neurol. 2009 Dec;66(12):1476-81
references.pmid: 20008651
references.citation: Lancet Neurol. 2010 Jan;9(1):119-28
references.pmid: 20083042
references.citation: Arch Neurol. 2000 Mar;57(3):339-44
references.pmid: 10714659
references.citation: Neurology. 2004 Feb 24;62(4):591-600
references.pmid: 14981176
references.citation: Neurology. 2001 Jul 24;57(2):216-25
references.pmid: 11468305
references.citation: AJNR Am J Neuroradiol. 2009 Feb;30(2):404-10
references.pmid: 19001534
references.citation: Psychiatry Res. 2003 Oct 15;120(3):231-8
references.pmid: 14561434
references.citation: Neurology. 1999 May 12;52(8):1687-9
references.pmid: 10331700
references.citation: J Nucl Med. 2007 Dec;48(12):1961-70
references.pmid: 18006622
references.citation: J Intern Med. 2004 Sep;256(3):205-23
references.pmid: 15324364
references.citation: Ann Neurol. 2004 Mar;55(3):306-19
references.pmid: 14991808