[Clinical significance of determination of serum B7-H4 in patients with malignant hematologic diseases].
OBJECTIVE
To study the clinical significance of determination of serum B7-H4 in patients with malignant hematologic diseases.


METHODS
Serum B7-H4 levels were determined in 65 patients with leucemia, 34 patients with lymphoma, 12 patients with multiple myeloma as well as in 50 healthy controls.


RESULTS
The serum B7-H4 levels in patients with lymphoma [(38.81+/-10.34) kappag/L] were significantly higher than healthy controls [(31.62+/-9.850) kappag/L] (P<0.01). But there are no significant difference of B7-H4 levels in serum among patients with leucemia, patients with multiple myeloma and healthy controls.


CONCLUSIONS
These results suggest that the B7-H4 may correlated with lymphoma, but uncorrelated with leucemia and multiple myeloma. Measurement of serum B7-H4 level provide useful information for distinctive diagnosis of different kinds of malignant hematologic diseases.
Wang
Xiao-Mei
XM
Department of Clinical Laboratory Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
Hu
Guo-Yan
GY
Liu
Wei
W
Zheng
Shu-Hua
SH
Lv
Jing
J
Wang
Hong-Mei
HM
Xu
Jun-Fa
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D018122:B7-1 Antigen / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006402:Hematologic Diseases / Q000097:blood*; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000097:blood; D008223:Lymphoma / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood; D055815:Young Adult
D018122:B7-1 Antigen