title: Human posterior parietal cortex plans where to reach and what to avoid.
abstract: In this time-resolved functional magnetic resonance imaging (fMRI) study, we aimed to trace the neuronal correlates of covert planning processes that precede visually guided motor behavior. Specifically, we asked whether human posterior parietal cortex has prospective planning activity that can be distinguished from activity related to retrospective visual memory and attention. Although various electrophysiological studies in monkeys have demonstrated such motor planning at the level of parietal neurons, comparatively little support is provided by recent human imaging experiments. Rather, a majority of experiments highlights a role of human posterior parietal cortex in visual working memory and attention. We thus sought to establish a clear separation of visual memory and attention from processes related to the planning of goal-directed motor behaviors. To this end, we compared delayed-response tasks with identical mnemonic and attentional demands but varying degrees of motor planning. Subjects memorized multiple target locations, and in a random subset of trials targets additionally instructed (1) desired goals or (2) undesired goals for upcoming finger reaches. Compared with the memory/attention-only conditions, both latter situations led to a specific increase of preparatory fMRI activity in posterior parietal and dorsal premotor cortex. Thus, posterior parietal cortex has prospective plans for upcoming behaviors while considering both types of targets relevant for action: those to be acquired and those to be avoided.
authors.affiliation: California Institute of Technology, Division of Biology, Pasadena, California 91125, USA. a.lindner@medizin.uni-tuebingen.de
authors.forename: Axel
authors.initials: A
authors.lastname: Lindner
authors.forename: Asha
authors.initials: A
authors.lastname: Iyer
authors.forename: Igor
authors.initials: I
authors.lastname: Kagan
authors.forename: Richard A
authors.initials: RA
authors.lastname: Andersen
mesh_terms: D001288:Attention / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009068:Movement / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*
references.citation: J Neurophysiol. 2007 Jan;97(1):188-99
references.pmid: 16928798
references.citation: Nat Rev Neurosci. 2002 Mar;3(3):201-15
references.pmid: 11994752
references.citation: J Exp Psychol Gen. 1980 Dec;109(4):444-74
references.pmid: 6449531
references.citation: Brain. 1988 Jun;111 ( Pt 3):643-74
references.pmid: 3382915
references.citation: J Neurophysiol. 1983 May;49(5):1268-84
references.pmid: 6864250
references.citation: J Neurophysiol. 1989 Feb;61(2):331-49
references.pmid: 2918358
references.citation: J Neurophysiol. 1992 Apr;67(4):1003-5
references.pmid: 1588383
references.citation: J Neurosci. 2006 May 10;26(19):5098-108
references.pmid: 16687501
references.citation: Exp Brain Res. 2006 Mar;169(3):338-49
references.pmid: 16273397
references.citation: Neuron. 2004 Aug 5;43(3):415-25
references.pmid: 15294148
references.citation: Cereb Cortex. 2005 Jul;15(7):1064-74
references.pmid: 15563726
references.citation: Neuron. 2005 Mar 3;45(5):801-14
references.pmid: 15748854
references.citation: J Neurosci. 2002 Oct 15;22(20):9024-34
references.pmid: 12388609
references.citation: Nature. 1997 Mar 13;386(6621):167-70
references.pmid: 9062187
references.citation: Exp Brain Res. 1997 Jan;113(1):144-52
references.pmid: 9028783
references.citation: Annu Rev Neurosci. 2002;25:189-220
references.pmid: 12052908
references.citation: Cereb Cortex. 2005 Oct;15(10):1561-9
references.pmid: 15716470
references.citation: J Neurophysiol. 2002 Oct;88(4):2047-57
references.pmid: 12364527
references.citation: Neuropsychologia. 1997 Sep;35(9):1261-73
references.pmid: 9364496
references.citation: Exp Brain Res. 2003 Nov;153(2):140-5
references.pmid: 12955383
references.citation: Neuroimage. 2002 Nov;17(3):1207-16
references.pmid: 12414261
references.citation: J Neurophysiol. 2002 Feb;87(2):1149-54
references.pmid: 11826082
references.citation: Exp Brain Res. 2003 Jun;150(3):276-89
references.pmid: 12684730
references.citation: J Neurophysiol. 1997 May;77(5):2252-67
references.pmid: 9163356
references.citation: Cereb Cortex. 2005 Sep;15(9):1281-9
references.pmid: 15616130
references.citation: Cortex. 2008 May;44(5):507-20
references.pmid: 18387584
references.citation: Science. 2000 Jun 2;288(5471):1656-60
references.pmid: 10834847
references.citation: Exp Brain Res. 1995;103(3):460-70
references.pmid: 7789452
references.citation: Behav Brain Res. 1982 Sep;6(1):57-77
references.pmid: 7126325
references.citation: Neuroimage. 2007;36 Suppl 2:T69-76
references.pmid: 17499172
references.citation: J Neurosci. 2006 Mar 8;26(10):2704-13
references.pmid: 16525049
references.citation: J Neurophysiol. 2004 Feb;91(2):873-89
references.pmid: 14523078
references.citation: Exp Brain Res. 1981;42(2):223-7
references.pmid: 7262217
references.citation: Nat Neurosci. 2002 Dec;5(12):1345-52
references.pmid: 12411958
references.citation: Trends Neurosci. 1992 Jan;15(1):20-5
references.pmid: 1374953
references.citation: Neuroimage. 2007 Feb 1;34(3):1209-19
references.pmid: 17134914
references.citation: PLoS Biol. 2010 Aug 03;8(8):e1000444
references.pmid: 20689802
references.citation: J Neurosci. 2003 Jun 1;23(11):4689-99
references.pmid: 12805308
references.citation: J Neurosci. 2000 Aug 1;20(15):5835-40
references.pmid: 10908625
references.citation: Neuron. 2009 Sep 10;63(5):568-83
references.pmid: 19755101
references.citation: Neuron. 2004 Aug 5;43(3):297-9
references.pmid: 15294137
references.citation: Annu Rev Psychol. 2010;61:169-90, C1-3
references.pmid: 19575625
references.citation: Neuroimage. 2006 Nov 1;33(2):644-59
references.pmid: 16949303
references.citation: J Neurophysiol. 2006 Jun;95(6):3923-7
references.pmid: 16467423
references.citation: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
references.pmid: 10393989
references.citation: Science. 2004 Jul 9;305(5681):258-62
references.pmid: 15247483
references.citation: J Neurophysiol. 2006 Mar;95(3):1645-55
references.pmid: 16291802
references.citation: Can J Exp Psychol. 2003 Sep;57(3):203-20
references.pmid: 14596478
references.citation: J Neurophysiol. 2006 Sep;96(3):1420-4
references.pmid: 16624996
references.citation: Neuron. 2007 Nov 8;56(3):552-9
references.pmid: 17988637
references.citation: J Neurosci. 2004 Apr 21;24(16):3944-52
references.pmid: 15102910
references.citation: Annu Rev Neurosci. 1999;22:319-49
references.pmid: 10202542
references.citation: Science. 2004 Jun 18;304(5678):1782-7
references.pmid: 15205529
references.citation: Nature. 1999 Jul 15;400(6741):233-8
references.pmid: 10421364
references.citation: Neuron. 1999 Apr;22(4):751-61
references.pmid: 10230795
references.citation: J Neurophysiol. 2005 Feb;93(2):954-62
references.pmid: 15356184