title: HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen.
abstract: There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.
authors.affiliation: Rebecca and John Moores Cancer Center, University of California San Diego (UCSD), La Jolla, CA 92093, USA.
authors.forename: R
authors.initials: R
authors.lastname: Saenz
authors.forename: C da Silva
authors.initials: Cda S
authors.lastname: Souza
authors.forename: C-T
authors.initials: CT
authors.lastname: Huang
authors.forename: M
authors.initials: M
authors.lastname: Larsson
authors.forename: S
authors.initials: S
authors.lastname: Esener
authors.forename: D
authors.initials: D
authors.lastname: Messmer
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies / Q000097:blood; D000941:Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D016207:Cytokines / Q000097:blood; D005260:Female; D024243:HMGB1 Protein / Q000276:immunology*; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000906:Antibodies; D000941:Antigens; D016207:Cytokines; D024243:HMGB1 Protein; D010455:Peptides; D010047:Ovalbumin
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