title: Cholesteryl ester transfer protein Taq1B polymorphism in an angiographically assessed Turkish population: no effects on coronary artery disease risk.
abstract: BACKGROUND
  Taq1B polymorphism of cholesteryl ester transfer protein (CETP) is believed to associate with high-density lipoprotein-cholesterol (HDL-C) levels and may alter the susceptibility to atherosclerosis.
  
  
  OBJECTIVE
  This study investigated the effects of Taq1B polymorphism on HDL-C and coronary artery disease (CAD) risk in angiographically defined CAD patients.
  
  
  METHODS
  One hundred thirty-five CAD patients and 112 healthy controls were screened for the CETP Taq1B genotype and plasma lipids.
  
  
  RESULTS
  The genotype frequency of CAD patients and controls were similar. The HDL-C levels of all genotypes in the CAD group were significantly lower than the corresponding controls. Smoking and plasma triglycerides were the predictors of the HDL-C level in B1B1 bearers, whereas the subjects with a polymorphic B2 allele were affected by smoking and sex.
  
  
  CONCLUSIONS
  CETP Taq1B polymorphism neither plays a role in determining HDL-C levels nor is a useful predictor of the risk of CAD.
authors.affiliation: Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. sevdat@istanbul.edu.tr
authors.forename: Sevda
authors.initials: S
authors.lastname: Tanrikulu-Kucuk
authors.forename: Evin
authors.initials: E
authors.lastname: Ademoglu
authors.forename: Figen
authors.initials: F
authors.lastname: Gurdol
authors.forename: Ahmet K
authors.initials: AK
authors.lastname: Bilge
authors.forename: Umit
authors.initials: U
authors.lastname: Mutlu-Turkoglu
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Nisanci
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics* / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D014421:Turkey / Q000453:epidemiology
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D014280:Triglycerides; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases