Cyclooxygenase-2 network as predictive molecular marker for clinical pregnancy in in vitro fertilization.
The gene expression of human endometrium on the day of oocyte retrieval of pregnant and nonpregnant patients in a stimulated IVF cycle was compared in two independent groups with different GnRH-antagonist ovarian stimulation protocols. The present data suggest that increased gene expression of cyclooxygenase-2, together with the expression of other molecules in the cyclooxygenase-2 network, on the day of oocyte retrieval in GnRH-antagonist cycles coincides with a lower probability of achieving a clinical pregnancy in this cycle.
Van Vaerenbergh
Inge
I
Department of Pathology, Vrije Universiteit Brussel and UZ Brussel, Jette, Belgium. ivvaeren@vub.ac.be
Blockeel
Christophe
C
Van Lommel
Leentje
L
Ghislain
Vanessa
V
In't Veld
Peter
P
Schuit
Frans
F
Fatemi
Human Mousavi
HM
Devroey
Paul
P
Bourgain
Claire
C
D015415:Biomarkers; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D004717:Endometrium / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015415:Biomarkers; D051546:Cyclooxygenase 2