Gold(I)-catalyzed cyclization of β-allenylhydrazones: an efficient synthesis of multisubstituted N-aminopyrroles.
The gold(I)-catalyzed cycloisomerization of β-allenylhydrazones provides an efficient access to multisubstituted N-aminopyrroles, which are obtained in good to excellent yields. This new intramolecular cyclization method can be applied either to alkyl- or aryl-substituted allenes. The reaction proceeds under mild conditions with short reaction times through a selective intramolecular 1,2-alkyl or -aryl migration extending the general scope of the reaction.
Benedetti
Erica
E
Institut Parisien de Chimie Moléculaire (UMR CNRS 7201), FR 2769 UPMC-Paris 06, C. 229, 4 Place Jussieu, 75005, Paris, France.
Lemière
Gilles
G
Chapellet
Laure-Lise
LL
Penoni
Andrea
A
Palmisano
Giovanni
G
Malacria
Max
M
Goddard
Jean-Philippe
JP
Fensterbank
Louis
L