Estimation of radiation exposure of 128-slice 4D-perfusion CT for the assessment of tumor vascularity.
OBJECTIVE
We aimed to estimate the effective dose of 4D-Perfusion-CT protocols of the lung, liver, and pelvis for the assessment of tumor vascularity.


METHODS
An Alderson-Rando phantom equipped with thermoluminescent dosimeters was used to determine the effective dose values of 4D-Perfusion-CT. Phantom measurements were performed on a 128-slice single-source scanner in adaptive 4D-spiral-mode with bidirectional table movement and a total scan range of 69 mm over a time period of nearly 120 seconds (26 scans). Perfusion measurements were simulated for the lung, liver, and pelvis under the following conditions: lung (80 kV, 60 mAs), liver (80 kV/80 mAs and 80 kV/120 mAs), pelvis (100 kV/80 mAs and 100 kV/120 mAs).


RESULTS
Depending on gender, the evaluated body region and scan protocol, an effective whole-body dose between 2.9-12.2 mSv, was determined. The radiation exposure administered to gender-specific organs like the female breast tissue (lung perfusion) or to the ovaries (pelvic perfusion) led to an increase in the female specific dose by 86% and 100% in perfusion scans of the lung and the pelvis, respectively.


CONCLUSIONS
Due to a significant radiation dose of 4D-perfusion-CT protocols, the responsible use of this new promising technique is mandatory. Gender- and organ-specific differences should be considered for indication and planning of tumor perfusion scans.
Ketelsen
Dominik
D
Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Strasse 3, Tuebingen, Germany. dominik.ketelsen@med.unituebingen.de
Horger
Marius
M
Buchgeister
Markus
M
Fenchel
Michael
M
Thomas
Christoph
C
Boehringer
Nadine
N
Schulze
Maximilian
M
Tsiflikas
Ilias
I
Claussen
Claus D
CD
Heuschmid
Martin
M
D005260:Female; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D011829:Radiation Dosage
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