title: Hydrogen sulfide, the third gaseous signaling molecule with cardiovascular properties, is decreased in hemodialysis patients.
abstract: Hydrogen sulfide, H(2)S, is the third endogenous gas with cardiovascular properties, after nitric oxide and carbon monoxide. H(2)S is a potent vasorelaxant, and its deficiency is implicated in the pathogenesis of hypertension and atherosclerosis. Cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase catalyze H(2)S formation. Chronic kidney disease is characterized by high prevalence of hyperhomocysteinemia, hypertension, and high cardiovascular mortality, especially in hemodialysis patients. H(2)S levels are decreased in hemodialysis patients through transcriptional deregulation of genes encoding for the H(2)S-producing enzymes. Potential implications relate to the pathogenesis of the manifestations of the uremic syndrome, such as hypertension and atherosclerosis.
authors.affiliation: First Division of Nephrology, Department of Clinical and Experimental Internal Medicine, Second University of Medicine, Naples, Italy. alessandra.perna@unina2.it
authors.forename: Alessandra F
authors.initials: AF
authors.lastname: Perna
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Luciano
authors.forename: Diego
authors.initials: D
authors.lastname: Ingrosso
authors.forename: Ilaria
authors.initials: I
authors.lastname: Raiola
authors.forename: Paola
authors.initials: P
authors.lastname: Pulzella
authors.forename: Immacolata
authors.initials: I
authors.lastname: Sepe
authors.forename: Diana
authors.initials: D
authors.lastname: Lanza
authors.forename: Eleonora
authors.initials: E
authors.lastname: Violetti
authors.forename: Rosanna
authors.initials: R
authors.lastname: Capasso
authors.forename: Cinzia
authors.initials: C
authors.lastname: Lombardi
authors.forename: Natale G
authors.initials: NG
authors.lastname: De Santo
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood* / Q000378:metabolism; D020138:Hyperhomocysteinemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D006435:Renal Dialysis; D013466:Sulfurtransferases / Q000378:metabolism; D014511:Uremia / Q000097:blood / Q000201:enzymology; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D013466:Sulfurtransferases; C021550:3-mercaptopyruvate sulphurtransferase; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide