The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.
During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion. We conclude that the microenvironment is a critical determinant of the migration strategy and the efficiency of cancer cell invasion.
Brábek
Jan
J
Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic. brabek@natur.cuni.cz.
Mierke
Claudia T
CT
Rösel
Daniel
D
Veselý
Pavel
P
Fabry
Ben
B
Mol Biol Cell. 1999 Oct;10(10):3067-79
10512851
Clin Exp Metastasis. 2009;26(4):289-98
18600304
Nat Rev Mol Cell Biol. 2001 Nov;2(11):793-805
11715046
Annu Rev Cell Biol. 1993;9:541-73
8280471
J Cell Biol. 2009 Apr 6;185(1):11-9
19332889
Cell. 1992 Aug 7;70(3):401-10
1643658
Circ Res. 2008 Jun 6;102(11):1307-18
18535268
J Biol Chem. 2005 Mar 25;280(12):11675-82
15661741
Cell. 2009 Nov 25;139(5):891-906
19931152
Mol Cancer Res. 2008 Sep;6(9):1410-20
18819929
Curr Opin Cell Biol. 1989 Oct;1(5):1009-19
2697287
J Immunol. 2010 Jan 15;184(2):1049-61
20018633
J Biol Chem. 2001 Sep 7;276(36):33762-72
11448946
J Cell Biol. 2004 Oct 25;167(2):223-9
15504909
Nat Methods. 2008 Dec;5(12):1019-21
18997781
Biophys J. 2008 Oct;95(8):4013-24
18621811
Indian J Exp Biol. 1997 Jun;35(6):553-64
9357157
Clin Exp Metastasis. 1999 Jul;17(5):423-9
10651309
Biophys J. 2009 May 20;96(10):4326-35
19450503
Mol Biol Cell. 2001 Sep;12(9):2699-710
11553709
J Leukoc Biol. 1997 Feb;61(2):188-200
9021925
Biophys J. 2008 Apr 1;94(7):2832-46
18096634
Oncogene. 2006 Sep 21;25(42):5726-40
16652152
J Leukoc Biol. 2001 Oct;70(4):491-509
11590185
Cancer Res. 2009 May 15;69(10):4167-74
19435897
Cancer Cell. 2008 Mar;13(3):221-34
18328426
Curr Oncol Rep. 2004 Mar;6(2):96-102
14751086
Oncogene. 2006 Oct 26;25(50):6563-73
16715142
Endocr Rev. 2007 May;28(3):297-321
17409287
Biomaterials. 2008 Jun;29(17):2597-607
18342366
Annu Rev Biochem. 2009;78:929-58
19344236
Nat Med. 2000 Jan;6(1):100-2
10613833
Biophys J. 2000 Jul;79(1):144-52
10866943
Trends Cell Biol. 2006 Apr;16(4):213-23
16529933
Nature. 1983 Jul 7-13;304(5921):30-4
6866086
Biophys J. 2008 Dec;95(11):5374-84
18775961
Science. 1996 Sep 13;273(5281):1551-5
8703217
Cell. 1995 Apr 7;81(1):53-62
7536630
Nat Cell Biol. 2007 Aug;9(8):893-904
17618273
J Cell Biol. 2003 Jan 20;160(2):267-77
12527751
Cell Motil Cytoskeleton. 1997;38(4):351-64
9415377
Immunology. 1994 Aug;82(4):617-24
7835926
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15619-24
17893336
Med Biol. 1978 Dec;56(6):299-303
366289
Cell. 1991 Jan 25;64(2):327-36
1703045
Science. 2003 Dec 5;302(5651):1704-9
14657486
Eur J Cell Biol. 2008 Sep;87(8-9):669-76
18295931
J Cell Biol. 2009 Feb 23;184(4):481-90
19221195
Curr Biol. 2006 Aug 8;16(15):1515-23
16890527
Am J Pathol. 1998 Sep;153(3):865-73
9736035
J Cell Biol. 1984 Sep;99(3):894-9
6381508
Cell Mol Life Sci. 2000 Jan 20;57(1):41-64
10949580
Cell Mol Life Sci. 2006 Feb;63(4):449-68
16416030
J Cell Biol. 2010 Jan 11;188(1):11-9
19951899
Cell. 1996 May 31;85(5):683-93
8646777
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9482-7
12874388
Mol Biol Cell. 2009 Jul;20(14):3224-38
19458194
J Cell Sci. 2010 Feb 1;123(Pt 3):431-40
20067998
Cancer Cell. 2005 Sep;8(3):241-54
16169468
Nat Med. 2006 Aug;12(8):895-904
16892035
Cell Mol Life Sci. 2010 Jan;67(1):63-71
19707854
Eur J Cell Biol. 2010 Sep;89(9):674-80
20537759
Curr Cancer Drug Targets. 2010 Mar;10(2):127-34
20088801
Oncogene. 1997 Oct;15(18):2169-77
9393975
J Leukoc Biol. 2006 Apr;79(4):779-88
16461737
Science. 1982 Sep 10;217(4564):998-1003
7112116
Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10889-94
16832052
Nat Cell Biol. 2003 Aug;5(8):711-9
12844144
Cell Motil Cytoskeleton. 2009 Jun;66(6):350-64
19422016
Ann N Y Acad Sci. 1992;668:317-9
1463274
J Cancer Res Clin Oncol. 2002 Oct;128(10):533-8
12384796
Blood. 2007 Mar 1;109(5):1938-44
17068152
Prostate. 1999 Oct 1;41(2):78-88
10477904
Trends Cell Biol. 1998 Feb;8(2):51-4
9695809