title: GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles.
abstract: To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.
authors.affiliation: Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. mikib@tasmc.health.gov.il
authors.forename: Miki
authors.initials: M
authors.lastname: Bloch
authors.forename: Foad
authors.initials: F
authors.lastname: Azem
authors.forename: Inbar
authors.initials: I
authors.lastname: Aharonov
authors.forename: Irit
authors.initials: I
authors.lastname: Ben Avi
authors.forename: Yaron
authors.initials: Y
authors.lastname: Yagil
authors.forename: Shaul
authors.initials: S
authors.lastname: Schreiber
authors.forename: Ami
authors.initials: A
authors.lastname: Amit
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001007:Anxiety / Q000139:chemically induced*; D003863:Depression / Q000139:chemically induced*; D004624:Embryo Transfer / Q000523:psychology; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro / Q000523:psychology; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007247:Infertility, Female / Q000523:psychology / Q000628:therapy*; D010062:Ovulation Induction / Q000009:adverse effects* / Q000379:methods / Q000523:psychology; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D011594:Psychometrics
chemical_list: D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol