Right man, right time, right place?--on the time course of the mediator orchestra in septic shock.
Appropriate timing of treatment assumes particular importance in critical care. Lange and colleagues recently reported on the time course of the different nitric oxide synthase (NOS) isoforms, nitrosative stress, and poly(ADP-ribosylation) during Pseudomonas aeruginosa pneumonia-induced ovine septic shock. Initially, endothelial NOS expression was increased together with markers of peroxynitrite formation, DNA damage, and nuclear factor-kappa-B activation. Later on, measurable NOS activity and nitric oxide production resulted mainly from inducible NOS activation. These results emphasize the need for long-term, large-animal studies investigated over days so that future therapeutic interventions can be better tailored and matched to the exact time course of the activation of the mediator orchestra.
Hauser
Balázs
B
Aneszteziológiai és Intenzív Terápiás Klinika, Semmelweis University, H-1125 Budapest, Kútvölgyi út 4, Hungary. bhauser1@gmail.com
Radermacher
Peter
P
D000818:Animals; D003422:Critical Care / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D019001:Nitric Oxide Synthase / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012772:Shock, Septic / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors
D017382:Reactive Oxygen Species; D019001:Nitric Oxide Synthase
Crit Care Med. 2009 Jan;37(1):223-9
19050630
Shock. 2010 Sep;34 Suppl 1:4-14
20523270
Shock. 2006 May;25(5):522-7
16680018
Shock. 2004 May;21(5):458-65
15087823
Shock. 2009 May;31(5):448-53
18827745
Shock. 2006 Jun;25(6):633-40
16721272
Curr Opin Anaesthesiol. 2008 Apr;21(2):111-21
18443476
Crit Care. 2010;14(4):R129
20602787
Br J Anaesth. 2010 Feb;104(2):183-90
20086063
Shock. 2009 Sep;32(3):253-7
19008779
Br J Anaesth. 2003 Feb;90(2):115-8
12538363
Anesth Analg. 2005 Aug;101(2):488-498
16037166
Crit Care Med. 2006 Feb;34(2):307-13
16424707
Crit Care. 2009;13(4):218
19664175
Shock. 2011 Feb;35(2):148-55
20577150
Shock. 2007 Jan;27(1):61-8
17172982
Shock. 2010 Sep;34(3):281-90
19997049
Shock. 2010 Sep;34(3):243-9
20160666