Construction of methylenecycloheptane frameworks through 7-exo-dig cyclization of acetylenic silyl enol ethers catalyzed by triethynylphosphine-gold complex.
A cationic gold(I) complex bearing a semihollow-shaped triethynylphosphine ligand efficiently catalyzed the 7-exo-dig cyclization of silyl enol ethers with an ω-alkynic substituent. The reaction gave various methylenecycloheptane derivatives with an exo- or endocyclic carbonyl group. The protocol was applicable not only to cyclic substrates that form bicyclic frameworks but also to acyclic ones with or without substituents in a carbon chain tether.
Ito
Hideto
H
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Ohmiya
Hirohisa
H
Sawamura
Masaya
M