Black-white divergence in the relation of white blood cell count to metabolic syndrome in preadolescents, adolescents, and young adults: the Bogalusa Heart Study.
OBJECTIVE
To examine the association between white blood cell (WBC) count and metabolic syndrome (MetS) by growth periods in black versus white individuals in the general population.


METHODS
The study cohort consisted of 4,184 black and white preadolescents, adolescents, and adults. In this cohort, 743 adults were followed for 8.1-20.8 years longitudinally.


RESULTS
White versus black subjects had a significantly higher WBC count in all age-groups. WBC count was associated with more MetS components in whites than in blacks. Mean values of WBC increased significantly with increasing number of MetS components with adverse levels in adolescents and adults, with a stronger trend in whites. WBC count was longitudinally associated with MetS in whites only (P<0.001).


CONCLUSIONS
The findings on the association between higher WBC count and MetS beginning in childhood, particularly in whites, underscore a potentially mechanistic link between systemic inflammation, MetS, and cardiovascular risk.
Chen
Wei
W
Department of Epidemiology, Tulane Center for Cardiovascular Health, Tulane University, New Orleans, Louisiana, USA.
Srinivasan
Sathanur R
SR
Xu
Jihua
J
Berenson
Gerald S
GS
D000293:Adolescent; D000328:Adult; D044383:Black People; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D055105:Waist Circumference; D044465:White People; D055815:Young Adult
D008076:Cholesterol, HDL
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