[Progress in application of targeting viral vector regulated by microRNA in gene therapy: a review].
A safe and effective targeting viral vector is the key factor for successful clinical gene therapy. microRNA, a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The discovery of these kind regulatory elements provides a new approach to regulate gene expression more accurately. In this review, we elucidated the principle of microRNA in regulation of targeting viral vector. The applications of microRNA in the fields of elimination contamination from replication competent virus, reduction of transgene-specific immunity, promotion of cancer-targeted gene therapy and development of live attenuated vaccines were also discussed.
Zhang
Guohai
G
Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China.
Wang
Qizhao
Q
Zhang
Jinghong
J
Xu
Ruian
R
D005786:Gene Expression Regulation; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D014780:Viruses / Q000235:genetics* / Q000378:metabolism
D035683:MicroRNAs