Putting a finger on the switch.
The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.
Bieker
James J
JJ
D000328:Adult; D000375:Aging / Q000235:genetics* / Q000502:physiology; D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D047109:Fetal Development / Q000235:genetics / Q000502:physiology; D005319:Fetal Hemoglobin / Q000235:genetics* / Q000502:physiology; D005812:Genes, Switch / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D055544:beta-Globins / Q000235:genetics*
D051741:Kruppel-Like Transcription Factors; D055544:beta-Globins; C080774:erythroid Kruppel-like factor; D005319:Fetal Hemoglobin
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