New fluorescent trans-dihydrofluoren-3-ones from aldol-Robinson annulation-regioselective addition involved one-pot reaction.
An unexpected discovery of new trans-4-acetyl-1,9-dimethyl-4,4a-dihydro-3H-fluoren-3-ones from one pot reactions of benzaldehydes and acetylacetone is described. The synthetic mechanism and stereochemistry were discussed. These new derivatives exhibit good fluorescent properties in solutions.
Huo
Yingpeng
Y
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Qiu
Xu
X
Shao
Weiyan
W
Huang
Jianing
J
Yu
Yanjun
Y
Zuo
Yinglin
Y
An
Linkun
L
Du
Jun
J
Bu
Xianzhang
X
D000447:Aldehydes / Q000737:chemistry*; D045744:Cell Line, Tumor; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000447:Aldehydes; D005449:Fluorenes; D005456:Fluorescent Dyes; C116609:3-hydroxybutanal