GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles.
To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.
Bloch
Miki
M
Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. mikib@tasmc.health.gov.il
Azem
Foad
F
Aharonov
Inbar
I
Ben Avi
Irit
I
Yagil
Yaron
Y
Schreiber
Shaul
S
Amit
Ami
A
Weizman
Abraham
A
D000328:Adult; D000339:Affect / Q000187:drug effects; D001007:Anxiety / Q000139:chemically induced*; D003863:Depression / Q000139:chemically induced*; D004624:Embryo Transfer / Q000523:psychology; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro / Q000523:psychology; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007247:Infertility, Female / Q000523:psychology / Q000628:therapy*; D010062:Ovulation Induction / Q000009:adverse effects* / Q000379:methods / Q000523:psychology; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D011594:Psychometrics
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol