title: Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes.
abstract: BACKGROUND
  Obesity and diabetes in mice can be modified by dietary variables. Here we systematically analysed the effect of the sucrose and fat content and of the fat quality in New Zealand Obese mice, a mouse model of the metabolic syndrome.
  
  
  RESULTS
  Male NZO mice fed a semi-purified diet with sucrose exhibited an identical weight gain and diabetes incidence as controls without sucrose. In contrast, mice on a chow diet gained weight more slowly and developed diabetes approximately 10 weeks later than those on the semi-purified diet (energy density 3.05 vs. 3.85 kcal/g; fibre content 12.9 vs. 4.7%). In a second experimental series, neither the fat content (10 vs. 40% of the total energy) nor the quality of the fat (lard, safflower oil, or fish oil) of semi-purified diets modified weight gain. However, diabetes started approximately 2 weeks earlier and appeared more severe (blood glucose 30 vs. 20 mmol/l at week 13) in the high-fat diet group (energy density 4.58 kcal/g; fibre content 5.7%).
  
  
  CONCLUSIONS
  Obesity in NZO mice develops independent of the dietary sucrose or fat content, and of the fat quality. However, the dietary fat content accelerates the onset of diabetes without enhancing adiposity. In contrast, chow diet exerts an anti-adipogenic/anti-diabetogenic effect that appears to be due to its lower caloric density and/or its higher fibre content.
authors.affiliation: German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Pharmacology, Nuthetal, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Mirhashemi
authors.forename: S
authors.initials: S
authors.lastname: Scherneck
authors.forename: O
authors.initials: O
authors.lastname: Kluth
authors.forename: D
authors.initials: D
authors.lastname: Kaiser
authors.forename: H
authors.initials: H
authors.lastname: Vogel
authors.forename: R
authors.initials: R
authors.lastname: Kluge
authors.forename: A
authors.initials: A
authors.lastname: Schürmann
authors.forename: S
authors.initials: S
authors.lastname: Neschen
authors.forename: H-G
authors.initials: HG
authors.lastname: Joost
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D051379:Mice; D008820:Mice, Obese; D013395:Sucrose / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D013395:Sucrose