title: [Successful symptomatic treatment of epidermodysplasia verruciformis with imiquimod 5% cream].
abstract: A 19-year-old patient presented with epidermodysplasia verruciformis (EV). In this genodermatosis, pathogenetic factors such as infection by human papilloma viruses as well as sun exposure are considered responsible for the malignant transformation of EV lesions to skin cancer within decades. So far, several therapeutic strategies have been unsatisfactory. In our case HPV 5b was detected and the associated skin lesions were successfully treated with imiquimod 5% cream.
authors.affiliation: Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Ricklinger Str. 5, 30449, Hannover. Heratizadeh.Annice@MH-Hannover.de
authors.forename: A
authors.initials: A
authors.lastname: Heratizadeh
authors.forename: B
authors.initials: B
authors.lastname: Völker
authors.forename: E
authors.initials: E
authors.lastname: Kupsch
authors.forename: K
authors.initials: K
authors.lastname: Wichmann
authors.forename: A
authors.initials: A
authors.lastname: Kapp
authors.forename: T
authors.initials: T
authors.lastname: Werfel
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000009:adverse effects; D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000009:adverse effects; D001706:Biopsy; D003241:Consanguinity; D015344:DNA Probes, HPV; D004334:Drug Administration Schedule; D003875:Drug Eruptions / Q000209:etiology; D004819:Epidermodysplasia Verruciformis / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005148:Facial Dermatoses / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D006801:Humans; D000077271:Imiquimod; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis; D012867:Skin / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D015344:DNA Probes, HPV; D000077271:Imiquimod
references.citation: Br J Dermatol. 2006 Jul;155(1):207-8
references.pmid: 16792778
references.citation: Curr Opin Infect Dis. 2008 Apr;21(2):141-6
references.pmid: 18317036
references.citation: Semin Immunol. 2006 Dec;18(6):362-74
references.pmid: 17011789
references.citation: Exp Dermatol. 2003 Dec;12(6):721-8
references.pmid: 14714550
references.citation: J Am Acad Dermatol. 2007 May;56(5):882-6
references.pmid: 17368633
references.citation: Curr Top Microbiol Immunol. 2008;321:59-83
references.pmid: 18727487
references.citation: Nat Genet. 2002 Dec;32(4):579-81
references.pmid: 12426567
references.citation: Int J Dermatol. 2007 Nov;46 Suppl 3:45-7
references.pmid: 17973891
references.citation: J Gen Virol. 2009 Dec;90(Pt 12):2855-2864
references.pmid: 19692543
references.citation: J Invest Dermatol. 2005 Jul;125(1):xii-xiii
references.pmid: 15982294
references.citation: J Clin Microbiol. 1997 Jun;35(6):1304-10
references.pmid: 9163434
references.citation: Virology. 1991 Aug;183(2):793-8
references.pmid: 1649510
references.citation: J Invest Dermatol. 2010 Mar;130(3):841-8
references.pmid: 19924140
references.citation: J Clin Microbiol. 2004 Jul;42(7):3176-84
references.pmid: 15243079
references.citation: Arch Dermatol. 2004 Mar;140(3):317-24
references.pmid: 15023775
references.citation: Dis Markers. 2007;23(4):247-59
references.pmid: 17627060
references.citation: J Clin Virol. 2004 Feb;29(2):137-40
references.pmid: 14747034
references.citation: Arch Dermatol. 2002 May;138(5):649-54
references.pmid: 12020228
references.citation: Bull Cancer. 1978;65(2):169-82
references.pmid: 212144
references.citation: Br J Cancer. 2004 Jun 1;90(11):2203-9
references.pmid: 15150558