title: The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma.
abstract: BACKGROUND
  The purpose of the present study was to detect the presence of BASC-like stem cell-related indicators, such as clara cell secretory protein (CCSP), Octamer-4 (OCT4) and Bmi-1, and evaluate their implications in the prognosis of patients with lung adenocarcinoma.
  
  
  METHODS
  Specimens of 134 cases of lung adenocarcinoma were collected after radical surgery from January 1999 to June 2004.
  
  
  RESULTS
  One hundred and twenty-six cases showed cells that were positive for CCSP, 99 cases positive for OCT4, 91 cases simultaneous expression of CCSP and OCT4 and 74 cases positive for Bmi-1. Bmi-1 was significantly higher in patients at stage III compared to patients at stages I and II. The pattern of survival curves showed that Bmi-1 was a significant prognostic factor of poor overall survival in lung adenocarcinoma patients (P = 0.0000), and the patients with OCT4(+) expression showed a greater increase in mortality than OCT4(-) patients (P = 0.0103). The results of univariate and multivariate Cox analysis revealed that the pathological stages of tumor node metastases (P = 0.037), OCT4 (P = 0.046) and Bmi-1 expression (P = 0.001) were independent prognostic factors.
  
  
  CONCLUSIONS
  OCT4 and Bmi-1 may be good biomarkers to predict the prognosis of patients with completely resected lung adenocarcinoma.
authors.affiliation: Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Qiang-Gang
authors.initials: QG
authors.lastname: Dong
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Huang
authors.forename: Ai-Mi
authors.initials: AM
authors.lastname: Huang
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Shi
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Sha
authors.forename: Jiu-Xian
authors.initials: JX
authors.lastname: Feng
authors.forename: Qin
authors.initials: Q
authors.lastname: Geng
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Xu
authors.forename: Bao-hui
authors.initials: BH
authors.lastname: Han
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate; D014598:Uteroglobin / Q000378:metabolism*; D055815:Young Adult
chemical_list: C069077:BMI1 protein, human; D009687:Nuclear Proteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin; D063150:Polycomb Repressive Complex 1