Original and efficient synthesis of D-cycloserine.
A simple pathway for the preparation of D-cycloserine is presented. The intermediates and D-cycloserine were characterized by FT-IR, (1)H-NMR spectra and elemental analysis. D-Cycloserine can inhibit the growth of Mycobacterium tuberculosis and can be used as a second-line drug for the treatment of tuberculosis, especially for the use in developing countries.
Li
Xiaomeng
X
School of Chemical Engineering, Shandong Institute of Light Industry, Jinan, PR China.
Meng
Xia
X
Duan
Hongdong
H
Wang
Lizhen
L
Wang
Shixiao
S
Zhang
Yi
Y
Qin
Dawei
D
D003523:Cycloserine / Q000138:chemical synthesis*; D003906:Developing Countries; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D017550:Spectroscopy, Fourier Transform Infrared; D014376:Tuberculosis / Q000188:drug therapy*
D003523:Cycloserine