title: Reduced mortality with noninvasive hemodynamic monitoring of shock.
abstract: OBJECTIVE
  This study compared clinical outcomes associated with exposure to pulmonary artery catheters (PACs), central venous catheters (CVCs), arterial pressure waveform analysis for cardiac output (APCO), or no central monitoring (NCM) in patients with shock.
  
  
  METHODS
  We assessed 6929 consecutive patients from 2003 to 2006 within a surgical intensive care unit of a university hospital, identifying 237 mechanically ventilated patients with shock.
  
  
  RESULTS
  Adjusted for severity of illness, use of APCO monitoring, compared with other options, was associated with reduced intensive care unit mortality (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.18-0.77) and 28-day mortality (OR, 0.43; 95% CI, 0.22-0.85). Other monitors were not associated with changes of 28-day mortality (CVC: OR, 0.63; 95% CI, 0.34-1.17; PAC: OR, 0.78; 95% CI, 0.36-1.69) or were associated with increased risk (NCM: OR, 2.29; 95% CI, 1.14-4.61). There were significant differences in the fluid and vasoactive drug prescriptions among the groups.
  
  
  CONCLUSIONS
  This study supports an association between the use of APCO monitoring and reduction in mortality in shock compared with traditional methods of monitoring. Although it is impossible to exclude the role of unrecognized/unrecorded differences among the groups, these findings may result from differences in supportive care, directed by monitor technology.
authors.affiliation: Division of Critical Care in the Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. steven-hata@uiowa.edu
authors.forename: J Steven
authors.initials: JS
authors.lastname: Hata
authors.forename: Corey
authors.initials: C
authors.lastname: Stotts
authors.forename: Constance
authors.initials: C
authors.lastname: Shelsky
authors.forename: Emine O
authors.initials: EO
authors.lastname: Bayman
authors.forename: Anita
authors.initials: A
authors.lastname: Frazier
authors.forename: Jenny
authors.initials: J
authors.lastname: Wang
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Nickel
mesh_terms: D000328:Adult; D000368:Aged; D002405:Catheterization, Central Venous / Q000379:methods; D002407:Catheterization, Swan-Ganz / Q000379:methods; D005260:Female; D006439:Hemodynamics; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012769:Shock / Q000401:mortality* / Q000503:physiopathology*; D016019:Survival Analysis