Two cases with pulmonary mucosa-associated lymphoid tissue lymphoma successfully treated with clarithromycin.
A 70-year-old woman with a history of sinobronchial syndrome was admitted to the hospital because of a cough, sputum, and abnormal chest shadow. She was diagnosed with pulmonary mucosa-associated lymphoid tissue lymphoma (p-MALToma) based on results of a pathologic examination and the gene rearrangements in the Ig heavy chain on Southern blot hybridization. Although p-MALToma did not regress with conventional therapy, it was reduced after long-term treatment with clarithromycin (CAM) (200 mg/d). A 57-year-old woman with a history of Sjögren syndrome and lymphocytic interstitial pneumonia had a mass lesion in the left lower lung field. CT image-guided biopsy established a diagnosis of p-MALToma. The p-MALToma regressed with long-term treatment with CAM (200 mg/d), whereas Helicobacter pylori (HP) eradication therapy was not effective in concurrent atrophic gastritis with HP. It is suggested that CAM, a macrolide antibiotic, may be effective in some patients with p-MALToma.
Ishimatsu
Yuji
Y
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Mukae
Hiroshi
H
Matsumoto
Kiyoshi
K
Harada
Tatsuhiko
T
Hara
Atsuko
A
Hara
Shintaro
S
Amenomori
Misato
M
Fujita
Hanako
H
Sakamoto
Noriho
N
Hayashi
Tomayoshi
T
Kohno
Shigeru
S
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D020545:Respiratory Mucosa
D000900:Anti-Bacterial Agents; D017291:Clarithromycin