Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.
A growing number of human diseases are linked to abnormal gene expression which is largely controlled at the level of transcriptional initiation. The gene-specific activator promotes the initiation of transcription through its interaction with one or more components of the transcriptional initiation machinery, hence leading to stimulated transcriptional initiation or activation. However, all activator proteins do not target the same component(s) of the transcriptional initiation machinery. Rather, they can have different target specificities, and thus, can lead to distinct mechanisms of transcriptional activation. Two such distinct mechanisms of transcriptional activation in yeast are mediated by the SAGA (Spt-Ada-Gcn5-Acetyltransferase) and TFIID (Transcription factor IID) complexes, and are termed as "SAGA-dependent" and "TFIID-dependent" transcriptional activation, respectively. SAGA is the target of the activator in case of SAGA-dependent transcriptional activation, while the targeting of TFIID by the activator leads to TFIID-dependent transcriptional activation. Both the SAGA and TFIID complexes are highly conserved from yeast to human, and play crucial roles in gene activation among eukaryotes. The regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID are discussed here. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough!
Bhaumik
Sukesh R
SR
Department of Biochemistry and Molecular Biology, Southern Illnois University School of Medicine, Carbondale, IL 62901, USA. sbhaumik@siumed.edu
D056890:Eukaryota / Q000235:genetics*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D035362:Transcription Factor TFIID / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation / Q000235:genetics*
C507785:SAGA complex, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D035362:Transcription Factor TFIID; D046988:Proteasome Endopeptidase Complex
EMBO J. 1996 Jun 17;15(12):3093-104
8670810
Nat Struct Biol. 2000 Nov;7(11):1062-7
11062564
Cell. 2007 Feb 23;128(4):707-19
17320508
Mol Cell. 2008 Oct 10;32(1):96-105
18851836
Trends Biochem Sci. 1996 Mar;21(3):96-102
8882582
J Biol Chem. 1999 Aug 13;274(33):23480-90
10438527
EMBO J. 2005 Mar 9;24(5):997-1008
15719021
Mol Cell Biol. 2000 Dec;20(23):8709-19
11073972
Biochim Biophys Acta. 2004 Oct 5;1680(1):34-45
15451170
Genetics. 1997 Oct;147(2):451-65
9335585
Cell. 1994 Oct 7;79(1):107-17
7923369
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8472-7
15932940
Cell Cycle. 2005 Jul;4(7):919-26
15970672
Expert Opin Investig Drugs. 2008 Jun;17(6):879-95
18491989
Brief Funct Genomic Proteomic. 2006 Sep;5(3):179-89
16772277
Mol Cell. 1998 May;1(6):895-904
9660972
Genes Dev. 2009 Jul 1;23(13):1510-21
19571180
Mol Cell Biol. 2001 Dec;21(23):7892-900
11689682
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14654-8
8962109
Cell. 1998 Jul 24;94(2):239-49
9695952
Nature. 2005 Dec 22;438(7071):1181-5
16372014
Mol Cell. 2001 Dec;8(6):1243-54
11779500
Nature. 1996 Sep 19;383(6597):269-72
8805705
Mol Cell Biol. 2004 May;24(10):4104-17
15121833
Mol Cell. 2007 Sep 7;27(5):731-44
17803938
EMBO J. 1996 Aug 1;15(15):3951-63
8670900
Science. 2000 May 26;288(5470):1422-5
10827952
Nat Struct Biol. 1999 Jul;6(7):601-4
10404206
Trends Biochem Sci. 2001 Apr;26(4):250-7
11295558
Mutat Res. 2007 May 1;618(1-2):135-48
17337012
Nature. 2003 Jun 26;423(6943):1009-13
12827207
Mol Cell. 1998 Nov;2(5):683-92
9844640
Genes Dev. 1997 Jun 1;11(11):1381-95
9192867
Mol Biol Cell. 2006 Oct;17(10):4228-36
16855026
Mol Cell Biol. 2005 Jun;25(12):4863-72
15923605
Mol Cell Biol. 2005 Feb;25(3):1173-82
15657442
Mol Cell Biol. 2002 Aug;22(15):5367-79
12101232
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1461-6
11830665
Hum Mol Genet. 2004 Jun 15;13(12):1257-65
15115762
EMBO J. 2000 Nov 15;19(22):6141-9
11080160
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):192-6
8278363
Cell. 1997 Nov 14;91(4):431-4
9390550
Mol Cell Biol. 2005 Dec;25(23):10566-79
16287868
Genes Dev. 2001 Aug 1;15(15):1935-45
11485988
Cell. 2005 Nov 4;123(3):423-36
16269334
Mol Endocrinol. 1996 Dec;10(12):1632-45
8961272
Science. 2000 Jan 21;287(5452):501-4
10642555
Mol Endocrinol. 1997 Jul;11(8):1009-19
9212049
Cell. 1991 Aug 9;66(3):563-76
1907890
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8478-82
15932941
Mol Cell Biol. 2003 Dec;23(23):8829-45
14612422
Development. 2004 Nov;131(21):5297-308
15456720
Mol Cell. 2007 Jun 22;26(6):831-42
17588518
Genes Dev. 1997 Jul 1;11(13):1640-50
9224714
Crit Rev Biochem Mol Biol. 2008 Nov-Dec;43(6):419-33
19058045
Nat Genet. 2001 Apr;27(4):422-6
11279525
Biochemistry. 2001 Aug 7;40(31):9421-7
11478912
Science. 2001 Jun 22;292(5525):2333-7
11423663
Nat Struct Mol Biol. 2006 Feb;13(2):117-20
16429153
Genes Dev. 2004 Feb 1;18(3):333-43
14871930
Genetics. 2007 Dec;177(4):2007-17
18073420
Genes Dev. 2001 Jul 1;15(13):1619-24
11445536
EMBO Rep. 2009 Aug;10(8):843-50
19609321
Mol Cell Biol. 2002 Jun;22(12):4033-42
12024017
J Biol Chem. 1999 Feb 26;274(9):5895-900
10026213
Biochem Biophys Res Commun. 2002 Aug 30;296(4):991-9
12200147
EMBO J. 1997 Feb 3;16(3):555-65
9034338
PLoS One. 2009;4(4):e5029
19343176
Mol Cell Biol. 1995 May;15(5):2839-48
7739564
J Biol Chem. 2010 May 14;285(20):15489-15499
20189987
Mol Cell. 2009 Aug 14;35(3):352-64
19683498
Nature. 2000 Mar 23;404(6776):414-7
10746732
Front Biosci. 2001 Sep 01;6:D1054-64
11532604
Curr Opin Drug Discov Devel. 2008 Sep;11(5):616-25
18729013
Clin Transl Oncol. 2006 May;8(5):313-7
16760005
Nature. 2006 Jun 8;441(7094):774-8
16760983
Nature. 2007 Dec 13;450(7172):1082-5
18046332
Mol Cell Biol. 1998 Jun;18(6):3149-62
9584156
Cold Spring Harb Symp Quant Biol. 1998;63:167-71
10384280
Cell. 2001 Mar 23;104(6):817-27
11290320
Mol Cell. 2008 Mar 28;29(6):653-63
18374642
Clin Cancer Res. 2008 Mar 15;14(6):1649-57
18347166
Mol Cell. 2000 Dec;6(6):1309-20
11163205
Mol Cell Biol. 2006 Apr;26(8):3149-63
16581789
J Biol Chem. 2002 Nov 22;277(47):45502-9
12237304
J Surg Res. 2008 Mar;145(1):111-23
17714734
Curr Top Dev Biol. 2005;65:115-48
15642381
J Biol Chem. 2004 Jan 16;279(3):1867-71
14660634
Nature. 2005 Jan 27;433(7024):434-8
15647753
J Biol Chem. 2000 Jul 7;275(27):20295-301
10791958
Science. 2002 Apr 19;296(5567):548-50
11964484
J Biol Chem. 2009 Dec 18;284(51):35714-24
19843524
Semin Cell Dev Biol. 1999 Apr;10(2):169-77
10441070
Cold Spring Harb Symp Quant Biol. 2008;73:217-25
19022758
J Biol Chem. 2002 Mar 8;277(10):7989-95
11773077
Genes Cells. 1999 Sep;4(9):529-39
10526239
Mol Cell Biol. 2006 Jun;26(11):4095-110
16705163
Oncogene. 2001 Dec 13;20(57):8270-5
11781841
Nature. 2004 Dec 23;432(7020):1054-8
15616568
Mol Cell. 2008 Jan 18;29(1):102-11
18206973
Annu Rev Genet. 2000;34:77-137
11092823
Genes Dev. 2002 Mar 15;16(6):673-5
11963920
Mol Cell. 2005 May 13;18(4):399-402
15893723
Mol Cell Biol. 2005 Jul;25(13):5626-38
15964818
Nat Cell Biol. 2008 Jun;10(6):707-15
18488019
Curr Biol. 2002 Jul 23;12(14):1240-4
12176335
Cell. 2004 May 14;117(4):427-39
15137937
Mol Cell Biol. 2002 Nov;22(21):7365-71
12370284
Mol Cell. 2002 Mar;9(3):553-62
11931763
Curr Opin Cell Biol. 2009 Jun;21(3):344-51
19411170
Mol Cell. 1998 Dec;2(6):863-7
9885573
Genes Dev. 1999 Oct 1;13(19):2484-9
10521393
Mol Cell Biol. 2002 Aug;22(16):5650-61
12138177
Mol Biol Cell. 2008 Oct;19(10):4310-8
18667528
Genes Dev. 2007 Jan 1;21(1):112-23
17167105
Trends Biochem Sci. 2000 Feb;25(2):59-63
10664584
Nature. 1988 Oct 20;335(6192):683-9
3050531
Cell Mol Life Sci. 2009 Jul;66(13):2123-34
19308322
Genes Dev. 2007 Sep 1;21(17):2137-49
17704303
Mol Cell. 2005 Mar 18;17(6):752-4
15780930
J Biol Chem. 1999 Nov 19;274(47):33778-84
10559271
Mol Cell Biol. 2000 Jan;20(2):634-47
10611242
Nature. 1994 Oct 6;371(6497):523-7
7935765
Genes Dev. 2007 Nov 15;21(22):2855-60
18006682
Genes Dev. 1996 Nov 1;10(21):2657-83
8946909
Genes Dev. 2008 Oct 15;22(20):2811-22
18923079
Mol Cell Biol. 2001 Aug;21(15):5223-31
11438676
Mol Cell Biol. 2009 Jan;29(1):266-80
18936164
Nature. 2000 Jun 8;405(6787):701-4
10864329
Nature. 1997 Apr 10;386(6625):569-77
9121580
Trends Genet. 2003 Jun;19(6):321-9
12801725
Mol Cell Biol. 2005 Oct;25(20):9092-102
16199885
Annu Rev Biochem. 2006;75:243-69
16756492
Mol Cell Biol. 2003 Apr;23(8):2800-20
12665580
Mol Cell. 2003 Oct;12(4):983-90
14580348
Hum Mol Genet. 1998 Feb;7(2):177-86
9425224
Oncogene. 2007 Aug 13;26(37):5329-40
17694076
Science. 1999 Dec 10;286(5447):2151-3
10591645
Genes Dev. 2003 Nov 1;17(21):2648-63
14563679
Cell. 2002 Nov 1;111(3):381-92
12419248
J Biol Chem. 2008 Aug 1;283(31):21789-98
18515799
Cell. 1998 Nov 25;95(5):717-28
9845373
Cell. 1997 Aug 22;90(4):615-24
9288742
Annu Rev Biochem. 1999;68:1015-68
10872471
J Biol Chem. 2006 Sep 15;281(37):27346-55
16837462
Cell. 1998 Aug 7;94(3):363-74
9708738
Genes Dev. 2001 Oct 1;15(19):2503-8
11581155
Curr Biol. 2003 Feb 4;13(3):241-6
12573221
J Mol Biol. 2007 May 18;368(5):1292-306
17397863
Genes Dev. 2001 Apr 15;15(8):1021-30
11316795
Mol Cell Biol. 2002 Sep;22(18):6458-70
12192044
Mol Cell. 2005 Apr 29;18(3):369-78
15866178
Cell. 2002 Nov 1;111(3):369-79
12419247
Genes Dev. 2001 Aug 1;15(15):1946-56
11485989
EMBO J. 2008 Jan 23;27(2):394-405
18188155
J Cell Sci. 2003 May 1;116(Pt 9):1847-58
12665565
Crit Rev Biochem Mol Biol. 2006 May-Jun;41(3):105-78
16858867
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14706-9
12417740
Mol Cell. 2000 Dec;6(6):1297-307
11163204
Epigenetics Chromatin. 2009 Feb 18;2(1):2
19226466
Science. 2000 May 19;288(5469):1244-8
10818000
Leuk Res. 2008 Feb;32(2):275-85
17659339
Curr Opin Genet Dev. 2000 Apr;10(2):187-92
10753786
Development. 1996 Apr;122(4):1331-41
8620860
Mol Cell Biol. 2001 Aug;21(15):5109-21
11438666
Mol Cell. 2000 Jun;5(6):905-15
10911985
J Biol Chem. 1993 Aug 15;268(23):17554-8
8349634
Science. 2001 Aug 10;293(5532):1142-6
11498592
Cell. 2007 Oct 5;131(1):58-69
17884155
Mol Cell. 2007 Jul 20;27(2):332-8
17643381
Biochem Biophys Res Commun. 2000 Dec 20;279(2):568-73
11118327
Mol Cell. 2007 Jan 12;25(1):31-42
17218269
Nucleic Acids Res. 2006 Mar 03;34(5):1351-7
16517940
J Biol Chem. 2002 Aug 16;277(33):29496-502
12039950
Nucleic Acids Res. 2006;34(21):6225-32
17090597
J Biol Chem. 2010 Jan 22;285(4):2438-55
19940160
Mol Cell. 2008 Jan 18;29(1):92-101
18206972
Mol Cell Biol. 2003 May;23(9):3305-19
12697829
Mol Cell Biol. 2005 Jan;25(1):114-23
15601835
Development. 1998 Jan;125(1):125-34
9389670
Mol Cell. 2004 Feb 27;13(4):573-85
14992726
J Biol Chem. 1995 Aug 18;270(33):19337-44
7642611
Mol Cell Biol. 1999 Jan;19(1):86-98
9858534
Mol Cell Biol. 2009 Nov;29(22):6033-45
19737915
Oncogene. 2002 Feb 21;21(9):1411-22
11857084
Nature. 1996 Mar 28;380(6572):316-22
8598927
Blood. 2007 Apr 15;109(8):3177-88
17185464
Structure. 2006 Mar;14(3):511-20
16531235
Genes Dev. 1992 Jul;6(7):1319-31
1628834
Mol Cell Biol. 2003 Mar;23(6):1910-21
12612066
Science. 1999 Dec 10;286(5447):2153-6
10591646
Trends Biochem Sci. 2005 May;30(5):235-9
15896740
Mol Cell. 2006 Mar 17;21(6):861-71
16543154
Mol Cell Biol. 2007 Jan;27(1):297-311
17074814
RNA Biol. 2009 Apr-Jun;6(2):141-4
19246994
Structure. 2009 Mar 11;17(3):363-73
19278651
J Biol Chem. 1998 Sep 25;273(39):25015-9
9737957
EMBO J. 2003 Jul 1;22(13):3395-402
12840001
J Biol Chem. 1993 Jul 25;268(21):15325-8
8340360
Genes Dev. 1998 Mar 1;12(5):627-39
9499399
Cell. 1998 Jul 10;94(1):45-53
9674426
Mol Cell Biol. 1999 Aug;19(8):5486-94
10409738
J Neurochem. 2005 Aug;94(4):943-56
15992382
Mol Cell. 2002 Apr;9(4):823-33
11983173
Science. 2000 May 19;288(5469):1242-4
10817999
Cell Mol Life Sci. 2009 Apr;66(8):1419-33
19370393
FEBS Lett. 2005 Feb 7;579(4):909-15
15680973
Nucleic Acids Res. 1997 Jun 15;25(12):2274-83
9173976
Cell. 1996 Oct 4;87(1):137-46
8858156
Mol Cell. 2003 Jan;11(1):267-74
12535539
Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4706-19
17898295
Prog Mol Subcell Biol. 2002;29:85-107
11908074
Mol Cell Biol. 1997 Jan;17(1):519-27
8972232
Trends Biochem Sci. 1996 Sep;21(9):327-35
8870495
Mol Cell Biol. 2006 May;26(9):3339-52
16611979
EMBO J. 1993 Feb;12(2):489-99
8440239
Nature. 2006 Jun 8;441(7094):770-3
16760982
EMBO J. 2002 Jul 1;21(13):3424-33
12093743
Nature. 1990 Jul 26;346(6282):329-31
2142753
Hum Mol Genet. 1998 Feb;7(2):165-70
9425222
Annu Rev Pharmacol Toxicol. 2006;46:189-213
16402903