APOE and cholesterol homeostasis in Alzheimer's disease.
Converging evidence from clinical and pathological studies indicate the presence of important relationships between the ongoing deterioration of brain lipid homeostasis, vascular changes and the pathophysiology of sporadic Alzheimer's disease (AD). These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia. Moreover, recent clinical findings lend support to the notion that progressive deterioration of cholesterol homeostasis in AD is a central player in the disease pathophysiology and is, therefore, a potential therapeutic target for disease prevention.
Leduc
Valérie
V
Douglas Mental Health University Institute, 6875 Lasalle, Montreal (Verdun), Quebec, H4H 1R3, Canada.
Jasmin-Bélanger
Stéphanie
S
Poirier
Judes
J
D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000150:complications; D002784:Cholesterol / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D002784:Cholesterol