title: Numerical investigation of nanoparticle-assisted laser-induced interstitial thermotherapy toward tumor and cancer treatments.
abstract: In this work, we numerically investigated nanoparticle-assisted laser-induced interstitial thermotherapy for tumor/cancer treatments. The goal of the study was to investigate the therapeutic effects of treatment conditions including laser wavelength, power, exposure time, concentrations of tailored nanoparticles, and optical/thermal properties of the tissue that is under treatment. It was found that using absorbing preferential nanoparticles as the photothermal agent weakens fluence rate distributions in terms of lowering fluence rate peaks and reducing laser penetration depths. However, the local enhancement in laser photon absorption induced by nanoparticles is so significant that the reduced fluence rate will be balanced out, and the eventual medical hyperthermia is greatly prompted by using nanoparticles. Also, the results of numerical simulations indicated that with constant laser illumination, an increase in nanoparticle concentration beyond a certain range has only an insignificant impact on hyperthermia.
authors.affiliation: Department of Mechanical Engineering & Material Science, Rice University, 6100 Main Street, Houston, TX 77005-1892, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.forename: Andrew
authors.initials: A
authors.lastname: Meade
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Bayazitoglu
mesh_terms: D001921:Brain / Q000528:radiation effects; D001940:Breast / Q000528:radiation effects; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D007834:Lasers; D008297:Male; D008954:Models, Biological; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D011467:Prostate / Q000528:radiation effects; D016896:Treatment Outcome
references.citation: Nanomedicine (Lond). 2007 Feb;2(1):125-32
references.pmid: 17716198
references.citation: Nano Lett. 2005 Apr;5(4):709-11
references.pmid: 15826113
references.citation: Cancer Lett. 2004 Jun 25;209(2):171-6
references.pmid: 15159019
references.citation: Cancer Lett. 1996 Jan 2;98(2):169-73
references.pmid: 8556705
references.citation: Eng Comput. 2009;25(1):3-13
references.pmid: 20648233
references.citation: J Am Chem Soc. 2006 Feb 15;128(6):2115-20
references.pmid: 16464114
references.citation: Technol Cancer Res Treat. 2004 Feb;3(1):33-40
references.pmid: 14750891
references.citation: J Phys Chem B. 2006 Feb 2;110(4):1520-4
references.pmid: 16471708
references.citation: Angew Chem Int Ed Engl. 2004 Nov 19;43(45):6042-108
references.pmid: 15538757
references.citation: Annu Rev Phys Chem. 2003;54:331-66
references.pmid: 12626731
references.citation: Chembiochem. 2007 Jul 23;8(11):1237-40
references.pmid: 17569092
references.citation: Biophys J. 2003 Jun;84(6):4023-32
references.pmid: 12770906
references.citation: Phys Med Biol. 2004 Sep 21;49(18):N309-15
references.pmid: 15509078
references.citation: J Phys Chem B. 2006 Apr 13;110(14):7238-48
references.pmid: 16599493
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11600-5
references.pmid: 16087878
references.citation: Langmuir. 2005 Nov 8;21(23):10644-54
references.pmid: 16262332
references.citation: Small. 2005 Mar;1(3):325-7
references.pmid: 17193451
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13549-54
references.pmid: 14597719
references.citation: Med Phys. 2009 Apr;36(4):1351-8
references.pmid: 19472642