Evaluation of selected rheumatoid arthritis activity scores for office-based assessment.
OBJECTIVE
Patient-reported measures can quickly provide assessments of rheumatoid arthritis (RA) disease activity in the office setting and do not require a laboratory test or physician examination. The goal of our study was to establish the validity of patient-reported indices compared to the C-reactive protein-based Disease Activity Score (DAS28-CRP4).


METHODS
Baseline and 1-year followup DAS28-CRP4 data were obtained from 740 RA subjects and were compared to indices (MDHAQ, CDAI, RAPID, RADAI, GAS) according to cyclic citrullinated peptide (CCP) status and change at 1 year. Pairwise correlations were calculated for each index.


RESULTS
Among 740 subjects, mean age 57 years, disease duration 14 years, the CDAI (r = 0.84, Δ r = 0.80) and RAPID (r = 0.71, Δ r = 0.70) had the highest correlation with the DAS28-CRP4 scores at baseline and 1 year. These correlations were not influenced by CCP status, disease-modifying antirheumatic drug use, biologic use, or by disease duration.


CONCLUSIONS
In RA, the CDAI and RAPID correlated well with the DAS28-CRP4. They may both be practical and informative in the care of patients in the office setting.
Sullivan
Mary Beth
MB
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
Iannaccone
Christine
C
Cui
Jing
J
Lu
Bing
B
Batra
Kerri
K
Weinblatt
Michael
M
Shadick
Nancy A
NA
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000473:pathology* / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009819:Office Visits; D010456:Peptides, Cyclic / Q000097:blood; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D010456:Peptides, Cyclic; D002097:C-Reactive Protein