Smoking and risk for diabetes incidence and mortality in Korean men and women.
OBJECTIVE
Mounting evidence suggests that smoking is a cause of type 2 diabetes. We explored the association of cigarette smoking with diabetes incidence and mortality in a large cohort of Koreans.


METHODS
A 14-year prospective cohort study was performed on 1,236,443 Korean men and women, aged 30-95 years at baseline, who underwent standardized biennial medical examinations provided by the National Health Insurance Corporation (NHIC). Incident diabetes was identified on the basis of outpatient visits, hospitalization, or prescription medication treatment for diabetes, as captured in the NHIC database. Diabetes mortality was obtained through the national statistical office. Cox proportional hazards models were used to investigate associations of smoking with indicators of diabetes and diabetes mortality.


RESULTS
Smoking was significantly associated with increased risk for diabetic outpatient treatment, hospitalization, and mortality among both men and women, and the risk among current smokers increased modestly with the number of cigarettes smoked daily (P(trend) < 0.0001 for all associations). Compared with never smokers, current male smokers who smoked ≥ 20 cigarettes/day had increased risk for incident diabetes defined by outpatient treatment (adjusted hazard ratio 1.55 [1.51-1.60]), incident diabetes defined by ≥ 3 prescription medications for diabetes (1.71 [1.63-1.80]), and death from diabetes (1.60 [1.25-2.06]). The risks for outpatient treatment among smokers were higher in men than in women with evidence for effect modification by sex and age (P(interaction) < 0.0001).


CONCLUSIONS
Our study provides longitudinal evidence that smoking increases the risk of incident diabetes and mortality.
Jee
Sun Ha
SH
Department of Epidemiology and Health Promotion and Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. jsunha@yuhs.ac
Foong
Athena W
AW
Hur
Nam Wook
NW
Samet
Jonathan M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
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