title: Multiwalled carbon nanotube filter: improving viral removal at low pressure.
abstract: The effective removal of viruses by a multiwalled carbon nanotube (MWNT) filter is demonstrated over a range of solution chemistries. MS2 bacteriophage viral removal by the MWNT filter was between 1.5 and 3 log higher than that observed with a recently reported single-walled carbon nanotube (SWNT) filter when examined under similar loadings (0.3 mg/cm(2)) of carbon nanotubes (CNTs). The greater removal of viruses by the MWNT filter is attributed to a more uniform CNT-filter matrix that allows effective removal of viruses by physicochemical (depth) filtration. Viral removal by the MWNT filter was examined under a broad range of water compositions (ionic strength, monovalent and divalent salts, solution pH, natural organic matter, alginate, phosphate, and bicarbonate) and filter approach velocities (0.0016, 0.0044, and 0.0072 cm/s). Log viral removal increased as the fluid approach velocity decreased, exhibiting a dependence on approach velocity in agreement with colloid filtration theory for Brownian particles. Viral removal improved with increasing ionic strength (NaCl), from 5.06 log removal at 1 mM NaCl to greater than 6.56 log removal at 100 mM NaCl. Addition of calcium ions also enhanced viral removal, but the presence of magnesium ions resulted in a decrease in viral removal. Solution pH also played an important role in viral removal, with log removals of 8.13, 5.38, and 4.00 being documented at solution pH values of 3.0, 5.5, and 9.0, respectively. Dissolved natural organic matter (NOM) had a negligible effect on viral removal at low concentration (1 mg/L), but higher concentrations of NOM significantly reduced the viral removal by the MWNT filter, likely due to steric repulsion. Addition of alginate (model polysaccharide) also caused a marked decrease in viral removal by the MWNT filter. This highly scalable MWNT-filter technology at gravity-driven pressures presents new, cost-effective options for point-of-use filters for viral removal.
authors.affiliation: Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut 06520-8286, USA.
authors.forename: Anna S
authors.initials: AS
authors.lastname: Brady-Estévez
authors.forename: Mary H
authors.initials: MH
authors.lastname: Schnoor
authors.forename: Chad D
authors.initials: CD
authors.lastname: Vecitis
authors.forename: Navid B
authors.initials: NB
authors.lastname: Saleh
authors.forename: Menachem
authors.initials: M
authors.lastname: Elimelech
mesh_terms: D000464:Alginates / Q000737:chemistry; D001639:Bicarbonates / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D004777:Environment; D005374:Filtration / Q000379:methods*; D057446:Hydrodynamics; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D017909:Levivirus / Q000302:isolation & purification; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009994:Osmolar Concentration; D010710:Phosphates / Q000737:chemistry; D011312:Pressure; D012492:Salts / Q000737:chemistry; D055672:Static Electricity; D014780:Viruses / Q000302:isolation & purification*; D018508:Water Purification / Q000379:methods*
chemical_list: D000464:Alginates; D001639:Bicarbonates; D037742:Nanotubes, Carbon; D010710:Phosphates; D012492:Salts; D002118:Calcium