Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.
The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus.
Higuchi
Sei
S
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Ohji
Makiko
M
Araki
Maiko
M
Furuta
Riyo
R
Katsuki
Mai
M
Yamaguchi
Ryuji
R
Akitake
Yoshiharu
Y
Matsuyama
Kiyoshi
K
Irie
Keiichi
K
Mishima
Kenji
K
Mishima
Kenichi
K
Iwasaki
Katsunori
K
Fujiwara
Michihiro
M
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D013759:Dronabinol / Q000031:analogs & derivatives / Q000494:pharmacology; D004435:Eating / Q000187:drug effects / Q000502:physiology; D063388:Endocannabinoids; D005518:Food Preferences / Q000187:drug effects / Q000502:physiology*; D005989:Glycerides / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011714:Pyrans / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors / Q000378:metabolism*
C508712:(6aR,10aR)-3-(1-methansulfonylamino-4-hexyn-6-yl)6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran; D001095:Arachidonic Acids; D004041:Dietary Fats; D063388:Endocannabinoids; D005989:Glycerides; D011714:Pyrans; D043884:Receptor, Cannabinoid, CB1; D013759:Dronabinol; C094503:glyceryl 2-arachidonate