A series of transition and non-transition metal complexes from a N₄O₂ hexadentate Schiff base ligand: Synthesis, spectroscopic characterization and efficient antimicrobial activities.
Some transition and non-transition metal complexes of the hexadentate N₄O₂ donor Schiff base ligand 1,8-N-bis(3-carboxy)disalicylidene-3,6-diazaoctane-1,8-diamine, abbreviated to H₄fsatrien, have been synthesized. All the 14 metal complexes have been fully characterized with the help of elemental analyses, molecular weights, molar conductance values, magnetic moments and spectroscopic (UV-Vis, IR, NMR, ESR) data. The analytical data helped to elucidate the structures of the metal complexes. The Schiff base, H₄fsatrien, is found to act as a dibasic hexadentate ligand using N₂N₂O₂ donor set of atoms (leaving the COOH group uncoordinated) leading to an octahedral geometry for the complexes around all the metal ions except VO²(+) and UO₂²(+). However, surprisingly the same ligand functions as a neutral hexadentate and neutral tetradentate one towards UO₂²(+) and VO²(+), respectively. In case of divalent metal complexes they have the general formula [M(H₂fsatrien)] (where M stands for Cu, Co, Hg and Zn); for trivalent metal complexes it is [M(H₂fsatrien)]X·nH₂O (where M stands for Cr, Mn, Fe, Co and X stands for CH₃COO, Cl, NO₃, ClO₄) and for the complexes of VO²(+) and UO₂²(+), [M(H₄fsatrien)]Y (where M=VO and Y=SO₄); M=UO₂ and Y=2 NO₃). The Schiff base ligand and most of the complexes have been screened in vitro to judge their antibacterial (Escherichia coli and Staphylococcus aureus) and antifungal (Aspergillus niger and Pencillium chrysogenum) activities.
Sarkar
Saikat
S
Department of Chemistry, Santipur College, Santipur 741404, West Bengal, India. saikat_s@rediffmail.com
Dey
Kamalendu
K
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008024:Ligands; D008826:Microbial Sensitivity Tests; D009589:Nitrogen Oxides; D010408:Penicillium chrysogenum / Q000187:drug effects; D012545:Schiff Bases / Q000737:chemistry; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D028561:Transition Elements / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D008024:Ligands; D009589:Nitrogen Oxides; D012545:Schiff Bases; D028561:Transition Elements