title: The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule?
abstract: She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Trcek
authors.forename: Robert H
authors.initials: RH
authors.lastname: Singer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003593:Cytoplasm / Q000378:metabolism*; D004330:Drosophila / Q000166:cytology / Q000196:embryology; D011485:Protein Binding; D014176:Protein Biosynthesis; D021381:Protein Transport; D012319:RNA Polymerase II / Q000378:metabolism; D020871:RNA Stability; D034443:RNA Transport; D012261:Ribonucleoproteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D012319:RNA Polymerase II
references.citation: Cell. 2009 Feb 20;136(4):719-30
references.pmid: 19239891
references.citation: EMBO J. 2000 Dec 1;19(23):6592-601
references.pmid: 11101531
references.citation: J Biol Chem. 2001 Apr 20;276(16):12959-66
references.pmid: 11278368
references.citation: Genes Dev. 2003 Jun 1;17(11):1402-14
references.pmid: 12782658
references.citation: Mol Biol Cell. 2009 Apr;20(8):2265-75
references.pmid: 19244342
references.citation: Mol Cell Biol. 2007 Dec;27(23):8340-51
references.pmid: 17893325
references.citation: Nat Struct Mol Biol. 2007 Sep;14(9):796-806
references.pmid: 17676063
references.citation: Genes Dev. 2000 Oct 15;14(20):2635-49
references.pmid: 11040217
references.citation: Genes Dev. 2008 Apr 15;22(8):1037-50
references.pmid: 18413716
references.citation: Trends Cell Biol. 2002 Oct;12(10):466-72
references.pmid: 12441250
references.citation: Curr Biol. 1999 Mar 25;9(6):333-6
references.pmid: 10209102
references.citation: Curr Opin Cell Biol. 1992 Dec;4(6):975-8
references.pmid: 1485968
references.citation: Science. 1997 Jul 18;277(5324):383-7
references.pmid: 9219698
references.citation: Science. 2009 Nov 27;326(5957):1212-6
references.pmid: 19965463
references.citation: EMBO Rep. 2008 Aug;9(8):781-7
references.pmid: 18566598
references.citation: Genes Dev. 2008 Aug 1;22(15):2022-7
references.pmid: 18676807
references.citation: Mol Cell Biol. 2005 Jun;25(11):4752-66
references.pmid: 15899876
references.citation: Curr Biol. 2003 Feb 4;13(3):199-207
references.pmid: 12573215
references.citation: J Cell Biol. 2003 Jan 6;160(1):77-87
references.pmid: 12507992
references.citation: Genes Dev. 2010 Sep 1;24(17):1914-26
references.pmid: 20713510
references.citation: Nature. 2003 Oct 16;425(6959):737-41
references.pmid: 14562106
references.citation: Genes Dev. 1998 Feb 1;12(3):357-69
references.pmid: 9450930
references.citation: Cell. 1996 Mar 8;84(5):687-97
references.pmid: 8625407
references.citation: Cell. 2007 Oct 5;131(1):174-87
references.pmid: 17923096
references.citation: J Biol Chem. 2002 May 31;277(22):19639-48
references.pmid: 11893740
references.citation: Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7045-50
references.pmid: 11416185
references.citation: Cell. 2009 May 15;137(4):708-20
references.pmid: 19450518
references.citation: Nature. 2004 Apr 29;428(6986):959-63
references.pmid: 15118729