[The changes of interdigestive migrating motor complex in rats with acute liver failure].
OBJECTIVE
To observe the changes and characteristics of interdigestive migrating motor complex (MMC) in rat models of acute liver failure.


METHODS
30 rat models with acute liver failure were induced with D-galactosamine and another 30 normal rats were used as controls. The indexes of MMC recorded by multi-channel physiological recorder were compared.


RESULTS
No significant differences found between the two groups in antral and duodenal MMC cycles and frequencies of duodenal and jejunal MMC III phase. Compared with normal controls, the MMC II phase in the acute liver failure rats was significantly prolonged (t=-3.97, -3.85, P<0.05), the MMC III duration of antrum and duodenum (u=-4.99, t=4.66, P<0.05) was shorter and the MMC III frequency of antrum (u=-4.73, P<0.05) was faster. In addition, the MMC cycle and MMC III phase of jejunum were significantly prolonged (u=-1.63, t=-4.94, P<0.05) and the MMC III phase duration was significantly shorter in the acute liver failure rats (t=5.10, P<0.05).


CONCLUSIONS
Significantly prolonged MMC II phase characterized by migrating clustered contraction, shortened MMC III phase and extended jejunal MMC cycles were probably the major contributors to the gastrointestinal motility disorders in the rats with acute liver failure.
Liu
Mei
M
Artificial LiverTreatment and Training Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Xu
Wei-hong
WH
Duan
Zhong-ping
ZP
Chen
Yu
Y
Zheng
Su-jun
SJ
Liu
Xu-hua
XH
Zhang
Jing
J
Zhao
Jun
J
Ding
Mei
M
Lü
Zhi-wu
ZW
D000818:Animals; D017114:Liver Failure, Acute / Q000503:physiopathology*; D016065:Myoelectric Complex, Migrating; D051381:Rats; D017208:Rats, Wistar