title: Updated guidelines for managing fungal diseases in hematology patients.
abstract: Many prospective open or comparative studies have been published over the last few years on antifungals. As invasive fungal disease remains an important cause of morbidity and mortality in high-risk hematology patients, the correct use of antifungal drugs, either as prophylaxis, empirical treatment in neutropenic patients or for therapy of overt disease, is of the utmost importance. Several international or national groups, including the Infectious Diseases Society of America and the European Conference on Infections in Leukaemia, have elaborated practice guidelines to improve the correct usage of antifungals. This article summarizes these guidelines, which have very similar recommendations, and comments on their evidence base.
authors.affiliation: Hematology Department, Henri Mondor Teaching Hospital, Assistance Publique-Hôpitaux de Paris and Paris 12 University, Créteil 94000, France.
authors.forename: Yosr
authors.initials: Y
authors.lastname: Hicheri
authors.forename: Andréa
authors.initials: A
authors.lastname: Toma
authors.forename: Sébastien
authors.initials: S
authors.lastname: Maury
authors.forename: Cécile
authors.initials: C
authors.lastname: Pautas
authors.forename: Hassina
authors.initials: H
authors.lastname: Mallek-Kaci
authors.forename: Catherine
authors.initials: C
authors.lastname: Cordonnier
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D009181:Mycoses / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D017410:Practice Guidelines as Topic
chemical_list: D000935:Antifungal Agents