title: Comorbid anxiety disorders and treatment of depression in people with multiple sclerosis.
abstract: OBJECTIVE
  Anxiety is highly comorbid with depression, but little is known about the impact of anxiety disorders on the effectiveness of empirically supported psychotherapies for depression. We examined such outcomes for people with Multiple Sclerosis (MS) and depression, with versus without comorbid anxiety disorders.
  
  
  METHODS
  Participants with MS (N = 102) received 16 weeks of telephone-administered psychotherapy for depression and were followed for one year post-treatment.
  
  
  RESULTS
  Participants with comorbid anxiety disorders improved to a similar degree during treatment as those without anxiety disorders. Outcomes during follow-up were mixed, and thus we divided the anxiety diagnoses into distress and fear disorders. The distress disorder (GAD) was associated with elevated anxiety symptoms during and after treatment. In contrast, fear disorders (i.e., panic disorder, agoraphobia, social phobia, specific phobia) were linked to depression, specifically during follow-up, across 3 different measures.
  
  
  CONCLUSIONS
  People with GAD receiving treatment for depression may benefit from additional services targeting anxiety more specifically, while those with comorbid fear disorders may benefit from services targeting maintenance of gains after treatment.
authors.affiliation: Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1220, Chicago, IL 60611, USA. mcobb03@yahoo.com
authors.forename: Michelle Nicole
authors.initials: MN
authors.lastname: Burns
authors.forename: Juned
authors.initials: J
authors.lastname: Siddique
authors.forename: J Konadu
authors.initials: JK
authors.lastname: Fokuo
authors.forename: David C
authors.initials: DC
authors.lastname: Mohr
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000150:complications* / Q000628:therapy; D003863:Depression / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000523:psychology*; D011613:Psychotherapy; D013689:Telephone; D016896:Treatment Outcome
references.citation: Arch Gen Psychiatry. 2005 Sep;62(9):1007-14
references.pmid: 16143732
references.citation: Mult Scler. 2001 Aug;7(4):237-42
references.pmid: 11548983
references.citation: J Psychiatr Res. 1990;24(4):335-50
references.pmid: 2090831
references.citation: Arch Neurol. 1992 Mar;49(3):238-44
references.pmid: 1536625
references.citation: Annu Rev Psychol. 1998;49:377-412
references.pmid: 9496627
references.citation: J Affect Disord. 2007 Nov;103(1-3):113-20
references.pmid: 17292480
references.citation: Arch Neurol. 1997 May;54(5):531-3
references.pmid: 9152109
references.citation: Eur J Neurol. 2008 Mar;15(3):239-45
references.pmid: 18215155
references.citation: Mult Scler. 1999 Aug;5(4):223-33
references.pmid: 10467380
references.citation: Neurology. 1996 Mar;46(3):628-32
references.pmid: 8618657
references.citation: Arch Neurol. 2001 Jul;58(7):1081-6
references.pmid: 11448297
references.citation: Am J Psychiatry. 2008 Mar;165(3):342-51
references.pmid: 18172020
references.citation: J Rehabil Res Dev. 2003 May-Jun;40(3):265-82
references.pmid: 14582530
references.citation: Clin Psychol (New York). 2008;15(3):243-253
references.pmid: 21369344
references.citation: Psychiatr Serv. 1998 Aug;49(8):1086-8
references.pmid: 9712219
references.citation: J Affect Disord. 2003 Dec;77(3):247-54
references.pmid: 14612224
references.citation: Int J Epidemiol. 1994 Feb;23(1):148-54
references.pmid: 8194911
references.citation: Cogn Behav Ther. 2009;38 Suppl 1:29-34
references.pmid: 22946137
references.citation: Behav Res Ther. 2003 May;41(5):509-28
references.pmid: 12711261
references.citation: Acta Psychiatr Scand. 1983 Jun;67(6):361-70
references.pmid: 6880820
references.citation: J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
references.pmid: 14399272
references.citation: Mult Scler. 2007 Jan;13(1):67-72
references.pmid: 17294613
references.citation: Disabil Rehabil. 2006 Mar 15;28(5):307-14
references.pmid: 16492625
references.citation: Am J Psychiatry. 1996 Oct;153(10):1293-300
references.pmid: 8831437
references.citation: Neurology. 2002 Sep 10;59(5):674-8
references.pmid: 12221156
references.citation: J Affect Disord. 2010 Jun;123(1-3):181-7
references.pmid: 19733912
references.citation: Behav Res Ther. 2008 Oct;46(10):1151-9
references.pmid: 18687420
references.citation: J Psychiatr Res. 1993 Jul-Sep;27(3):247-52
references.pmid: 8295157
references.citation: Depress Anxiety. 2008;25(4):282-8
references.pmid: 18415951
references.citation: Behav Ther. 2008 Jun;39(2):117-25
references.pmid: 18502245
references.citation: Behav Ther. 2016 Nov;47(6):838-853
references.pmid: 27993336
references.citation: J Abnorm Psychol. 2005 Nov;114(4):522-36
references.pmid: 16351375
references.citation: JAMA. 2003 Jun 18;289(23):3095-105
references.pmid: 12813115
references.citation: Psychol Bull. 1992 Jul;112(1):155-9
references.pmid: 19565683