Comparative study between on-pump and off-pump coronary artery bypass graft in women.
BACKGROUND
It has been well documented that women have higher morbidity and mortality rates than men following coronary artery bypass graft (CABG) surgery. In view of this evidence, it is necessary to know if there is benefit to off-pump CABG surgery in women in comparison to on-pump CABG.


OBJECTIVE
Compare outcomes between off-pump CABG and on-pump CABG in women.


METHODS
Retrospective study. Our investigation analyzes comparatively clinical profile, thirteen procedure complications and mortality of a population of 941 consecutive women undergoing CABG surgery (549 off-pump and 392 on-pump) at two hospitals for the period January 2000 to December 2005.


RESULTS
Mortality rate for women undergoing off-pump CABG surgery is lower than for women undergoing on-pump surgery, however, not statistically significant (3.1% vs 5.3%; P=0.134). The complication rates analyzed (hemorrhagic shock, neurologic, respiratory, acute renal failure, adult respiratory distress syndrome, septicemia, pneumonia, atrial fibrillation) were lower (significant statistically difference) for women off-pump than women on-pump, with the exception of low cardiac output and wound infection.


CONCLUSIONS
Evidence suggests that off-pump CABG surgery may be better for women than on-pump CABG surgery because it appears to reduce morbimortality rates. Ten of 13 complications investigated demonstrated an advantage for women undergoing off-pump surgery relative to those receiving on-pump surgery.
Sá
Michel Pompeu Barros de Oliveira
MP
Faculdade de Ciências Médicas, Universidade de Pernambuco. michel_pompeu@yahoo.com.br
Lima
Leonardo Pontual
LP
Rueda
Fábio Gonçalves de
FG
Escobar
Rodrigo Renda de
RR
Cavalcanti
Paulo Ernando Ferraz
PE
Thé
Emmanuel Callou da Silva
EC
Escobar
Mozart Augusto Soares de
MA
Lima
Ricardo de Carvalho
Rde C
D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects / Q000379:methods* / Q000401:mortality*; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D012737:Sex Factors