title: Microarray data analysis in neoadjuvant biomarker studies in estrogen receptor-positive breast cancer.
abstract: Microarray data have been widely utilized to discover biomarkers predictive of response to endocrine therapy in estrogen receptor-positive breast cancer. Typically, these data have focused on analyses conducted on the diagnostic specimen. However, dynamic temporal changes in gene expression associated with treatment may deliver significant improvements to the current generation of predictive models. We present and discuss some statistical issues relevant to the paper by Taylor and colleagues, who conducted studies to model the prognostic potential of gene expression changes that occur after endocrine treatment.
authors.forename: Jingqin
authors.initials: J
authors.lastname: Luo
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ellis
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
chemical_list: D004965:Estrogen Antagonists; D004967:Estrogens; D011960:Receptors, Estrogen; D013629:Tamoxifen; D004958:Estradiol
references.citation: J Natl Cancer Inst. 2003 Jan 1;95(1):14-8
references.pmid: 12509396
references.citation: BMC Genomics. 2008 May 22;9:239
references.pmid: 18498629
references.citation: Nat Biotechnol. 2006 Sep;24(9):1140-50
references.pmid: 16964228
references.citation: J Clin Oncol. 2009 Mar 10;27(8):1160-7
references.pmid: 19204204
references.citation: Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9121-6
references.pmid: 12082179
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8
references.pmid: 9843981
references.citation: Cancer Cell. 2004 Jun;5(6):607-16
references.pmid: 15193263
references.citation: Breast Cancer Res. 2010;12(3):R39
references.pmid: 20569502
references.citation: Nat Rev Cancer. 2002 Feb;2(2):101-12
references.pmid: 12635173
references.citation: N Engl J Med. 2004 Dec 30;351(27):2817-26
references.pmid: 15591335