title: Iron-catalyzed heterocycle and arene deprotonative alkylation.
abstract: A method for iron-catalyzed deprotonative alkylation of arene C-H bonds by alkyl iodides and bromides has been developed. In the presence of an amide base, both primary and secondary alkyl halides can be coupled with furans, thiophenes, pyridine derivatives, and some electron-withdrawing-group containing arenes.
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
authors.forename: Ly Dieu
authors.initials: LD
authors.lastname: Tran
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
mesh_terms: D000478:Alkylation; D002384:Catalysis; D006219:Halogens / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D011522:Protons
chemical_list: D006219:Halogens; D006571:Heterocyclic Compounds; D011522:Protons; D007501:Iron
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