title: Perceptual learning beyond retinotopic reference frame.
abstract: Repetitive experience with the same visual stimulus and task can remarkably improve behavioral performance on the task. This well-known perceptual-learning phenomenon is usually specific to the trained retinal- or visual-field location, which is taken as an indication of plastic changes in retinotopic visual areas. In previous studies of perceptual learning, however, a change in stimulus location on the retina is accompanied by positional changes of the stimulus in nonretinotopic frames of reference, such as relative to the head and other objects. It is unclear, therefore, whether the putative location specificity is exclusively retinotopic or if it could also depend on nonretinotopic representation of the stimulus, which is particularly important for multisensory and sensorimotor integration as well as for maintenance of stable visual percepts. Here, by manipulating subjects' gaze direction to control spatial and retinal locations of stimuli independently, we found that, when the stimulated retinal regions were held constant, the improvement with training in motion-direction discrimination of two successively displayed stimuli was restricted to the relative spatial position of the stimuli but independent of their absolute locations in head- and world-centered frame. These findings indicate location specificity of perceptual learning beyond retinotopic frame of reference, suggesting a pliable spatiotopic mechanism that can be specifically shaped by experience for better spatiotemporal integration of the learned stimuli.
authors.affiliation: Beijing Normal University, China.
authors.forename: En
authors.initials: E
authors.lastname: Zhang
authors.forename: Wu
authors.initials: W
authors.lastname: Li
mesh_terms: D006801:Humans; D007858:Learning; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology*; D014785:Vision, Ocular
references.citation: Nat Neurosci. 2007 Feb;10(2):249-55
references.pmid: 17195842
references.citation: J Neurophysiol. 1997 Dec;78(6):2889-94
references.pmid: 9405509
references.citation: Science. 1982 Nov 12;218(4573):697-8
references.pmid: 7134968
references.citation: Annu Rev Neurosci. 2001;24:57-86
references.pmid: 11283305
references.citation: Sci Am. 1962 May;206:62-72
references.pmid: 14457820
references.citation: Nat Neurosci. 2007 Jul;10(7):903-7
references.pmid: 17589507
references.citation: Nat Neurosci. 2001 May;4(5):519-25
references.pmid: 11319561
references.citation: Trends Cogn Sci. 2008 Dec;12(12):466-73
references.pmid: 18951831
references.citation: Neuron. 2002 Jan 3;33(1):143-9
references.pmid: 11779487
references.citation: Nat Neurosci. 2003 Aug;6(8):877-81
references.pmid: 12872128
references.citation: Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4966-70
references.pmid: 2052578
references.citation: J Neurophysiol. 2007 Feb;97(2):1738-55
references.pmid: 17093130
references.citation: Psychol Res. 1987;49(4):221-7
references.pmid: 3441580
references.citation: Nat Neurosci. 2004 Jun;7(6):651-7
references.pmid: 15156149
references.citation: J Physiol. 2009 Jun 15;587(Pt 12):2743-51
references.pmid: 19525560
references.citation: Nat Neurosci. 2006 Sep;9(9):1083-4
references.pmid: 16936766
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4026-31
references.pmid: 11904446
references.citation: Vision Res. 2008 Mar;48(8):1014-7
references.pmid: 18314156
references.citation: J Neurophysiol. 1983 May;49(5):1127-47
references.pmid: 6864242
references.citation: J Neurosci. 2008 May 14;28(20):5218-28
references.pmid: 18480278
references.citation: Trends Cogn Sci. 2010 Apr;14(4):147-53
references.pmid: 20189870
references.citation: Nature. 1997 Oct 23;389(6653):845-8
references.pmid: 9349815
references.citation: Nature. 1989 Sep 7;341(6237):52-4
references.pmid: 2770878
references.citation: Science. 1985 Oct 25;230(4724):456-8
references.pmid: 4048942
references.citation: Vision Res. 1987;27(6):953-65
references.pmid: 3660656
references.citation: Nat Neurosci. 2007 Apr;10(4):423-5
references.pmid: 17369824
references.citation: J Physiol. 2005 Jul 1;566(Pt 1):29-35
references.pmid: 15845586
references.citation: Cereb Cortex. 2007 May;17(5):1164-72
references.pmid: 16818474
references.citation: J Neurosci. 1997 May 1;17(9):3201-14
references.pmid: 9096154
references.citation: J Vis. 2008 Oct 23;8(14):2.1-17
references.pmid: 19146303
references.citation: Curr Biol. 2005 Oct 11;15(19):1745-8
references.pmid: 16213821
references.citation: Science. 1992 Jan 24;255(5043):419-23
references.pmid: 1734518
references.citation: Cereb Cortex. 2007 Dec;17(12):2914-32
references.pmid: 17389630
references.citation: Nat Rev Neurosci. 2002 Sep;3(9):741-7
references.pmid: 12209122
references.citation: Vision Res. 1973 Apr;13(4):877-80
references.pmid: 4706358
references.citation: J Neurophysiol. 1997 Jun;77(6):3267-72
references.pmid: 9212273
references.citation: J Neurophysiol. 1984 Dec;52(6):1106-30
references.pmid: 6520628
references.citation: Vision Res. 2006 Jun;46(13):2110-21
references.pmid: 16483629
references.citation: Nature. 1998 Aug 27;394(6696):887-91
references.pmid: 9732870
references.citation: Neuron. 2008 Feb 7;57(3):442-51
references.pmid: 18255036
references.citation: Science. 2008 Sep 12;321(5895):1502-7
references.pmid: 18787171
references.citation: J Neurosci. 2008 Oct 15;28(42):10654-62
references.pmid: 18923041
references.citation: Science. 1992 Jan 3;255(5040):90-2
references.pmid: 1553535
references.citation: J Neurophysiol. 2009 Oct;102(4):2435-40
references.pmid: 19692506
references.citation: Nature. 1999 Mar 18;398(6724):239-42
references.pmid: 10094046
references.citation: Am J Psychol. 1966 Sep;79(3):443-50
references.pmid: 5968481
references.citation: J Neurophysiol. 1997 Feb;77(2):944-61
references.pmid: 9065860
references.citation: Annu Rev Neurosci. 2003;26:331-54
references.pmid: 12626696
references.citation: Cereb Cortex. 1995 Sep-Oct;5(5):457-69
references.pmid: 8547792
references.citation: Vision Res. 2003 Mar;43(6):639-49
references.pmid: 12604100
references.citation: Prog Brain Res. 2002;140:165-80
references.pmid: 12508589