title: Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair.
abstract: It is well known that ionizing radiation (IR) can damage DNA through a direct action, producing single- and double-strand breaks on DNA double helix, as well as an indirect effect by generating oxygen reactive species in the cells. Mammals have evolved several and distinct DNA repair pathways in order to maintain genomic stability and avoid tumour cell transformation. This review reports important data showing a huge interindividual variability on sensitivity to IR and in susceptibility to developing cancer; this variability is principally represented by genetic polymorphisms, that is, DNA repair gene polymorphisms. In particular we have focussed on single nucleotide polymorphisms (SNPs) of XRCC1, a gene that encodes for a scaffold protein involved basically in Base Excision Repair (BER). In this paper we have reported and presented recent studies that show an influence of XRCC1 variants on DNA repair capacity and susceptibility to breast cancer.
authors.affiliation: Department of Biology, University of "Roma TRE", Viale Guglielmo Marconi 446, 00146 Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Sterpone
authors.forename: Renata
authors.initials: R
authors.lastname: Cozzi
references.citation: EMBO J. 2001 Nov 15;20(22):6530-9
references.pmid: 11707423
references.citation: Mutagenesis. 2009 Jul;24(4):331-9
references.pmid: 19465687
references.citation: Br J Cancer. 1998 Feb;77(4):614-20
references.pmid: 9484819
references.citation: Protein J. 2007 Dec;26(8):541-6
references.pmid: 17899335
references.citation: Cancer Res. 1998 Feb 15;58(4):604-8
references.pmid: 9485007
references.citation: Cancer Res. 2004 Jun 15;64(12):4378-84
references.pmid: 15205355
references.citation: Carcinogenesis. 2006 Dec;27(12):2469-74
references.pmid: 16829685
references.citation: J Biol Chem. 2003 Nov 7;278(45):44068-74
references.pmid: 12933815
references.citation: DNA Repair (Amst). 2003 Sep 18;2(9):955-69
references.pmid: 12967653
references.citation: Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):217-22
references.pmid: 11303590
references.citation: Environ Mol Mutagen. 2002;39(2-3):208-15
references.pmid: 11921191
references.citation: Oncogene. 2003 Sep 1;22(37):5792-812
references.pmid: 12947387
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):353-8
references.pmid: 16492928
references.citation: Mutat Res. 2005 Feb 15;570(1):105-17
references.pmid: 15680408
references.citation: Int J Cancer. 1999 Sep 24;83(1):83-90
references.pmid: 10449613
references.citation: Annu Rev Pharmacol Toxicol. 2001;41:367-401
references.pmid: 11264462
references.citation: Mol Cell Biol. 2002 Apr;22(8):2556-63
references.pmid: 11909950
references.citation: Nucleic Acids Res. 2005 May 02;33(8):2512-20
references.pmid: 15867196
references.citation: Cell Mol Life Sci. 2009 Mar;66(6):994-1009
references.pmid: 19153657
references.citation: Mutat Res. 2010 Feb 3;684(1-2):43-8
references.pmid: 19962393
references.citation: Cancer Res. 1999 Jun 1;59(11):2557-61
references.pmid: 10363972
references.citation: Cell Mol Life Sci. 2009 Mar;66(6):981-93
references.pmid: 19153658
references.citation: Nucleic Acids Res. 2006 Jan 05;34(1):32-41
references.pmid: 16397295
references.citation: Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1168-74
references.pmid: 14652276
references.citation: Cell Mol Life Sci. 2009 Mar;66(6):1021-38
references.pmid: 19153655
references.citation: Br J Cancer. 1996 Jul;74(1):1-5
references.pmid: 8679441
references.citation: Carcinogenesis. 2001 Jun;22(6):917-22
references.pmid: 11375899
references.citation: Mutat Res. 2000 Feb 16;459(1):1-18
references.pmid: 10677679
references.citation: J Biol Chem. 2004 Dec 31;279(53):55117-26
references.pmid: 15498778
references.citation: Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):537-45
references.pmid: 16965996
references.citation: Mutat Res. 2009 Sep-Oct;679(1-2):59-64
references.pmid: 19628051
references.citation: Blood. 2002 Nov 15;100(10):3761-6
references.pmid: 12393447
references.citation: Carcinogenesis. 2000 May;21(5):965-71
references.pmid: 10783319
references.citation: Cancer Lett. 2003 Feb 20;190(2):183-90
references.pmid: 12565173
references.citation: Breast Cancer Res Treat. 2009 May;115(1):137-44
references.pmid: 18481169
references.citation: J Natl Cancer Inst. 2006 Oct 4;98(19):1382-96
references.pmid: 17018785
references.citation: EMBO J. 1998 Nov 2;17(21):6404-11
references.pmid: 9799248
references.citation: Mutat Res. 2002 Nov 30;509(1-2):49-78
references.pmid: 12427531
references.citation: Toxicology. 2006 Feb 15;219(1-3):220-9
references.pmid: 16386346
references.citation: Radiat Res. 2005 Aug;164(2):132-40
references.pmid: 16038584
references.citation: Mutat Res. 2004 Nov 22;556(1-2):169-81
references.pmid: 15491645
references.citation: J Cancer Res Clin Oncol. 2010 Apr;136(4):631-6
references.pmid: 20140625
references.citation: Cell Mol Life Sci. 2002 Feb;59(2):373-85
references.pmid: 11915950
references.citation: Biochem Soc Trans. 2001 Nov;29(Pt 6):655-61
references.pmid: 11709049