3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry.
An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.
Denisenko
Aleksandr V
AV
Enamine Ltd., Vul. Oleksandra Matrosova 23, 01103 Kyiv, Ukraine.
Mityuk
Andrey P
AP
Grygorenko
Oleksandr O
OO
Volochnyuk
Dmytro M
DM
Shishkin
Oleg V
OV
Tolmachev
Andrey A
AA
Mykhailiuk
Pavel K
PK
D001593:Benzyl Compounds / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D006536:Heptanes / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure
C554397:3-benzyl-3-azabicyclo(3.1.1)heptan-6-one; D001593:Benzyl Compounds; D001643:Bridged Bicyclo Compounds; D006536:Heptanes