title: Neurologic manifestations of pediatric novel h1n1 influenza infection.
abstract: Reported neurologic manifestations of novel H1N1 influenza have included seizure, meningoencephalitis, and acute necrotizing encephalopathy. We describe the first series of pediatric patients presenting during the second wave of the US novel H1N1 pandemic, with protracted seizures, severe encephalopathy/encephalitis, and acute disseminated encephalomyelitis. In addition to prominent radiographic abnormalities, we provide the first observation and description of associated cerebrospinal fluid abnormalities.
authors.affiliation: Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Rellosa
authors.forename: Karen C
authors.initials: KC
authors.lastname: Bloch
authors.forename: Andi L
authors.initials: AL
authors.lastname: Shane
authors.forename: Roberta L
authors.initials: RL
authors.lastname: Debiasi
mesh_terms: D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000821:virology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000473:pathology / Q000821:virology*; D008297:Male; D008590:Meningoencephalitis / Q000473:pathology / Q000821:virology*; D012640:Seizures / Q000473:pathology / Q000821:virology*; D014481:United States