title: What can we learn about cardioprotection from the cardiac mitochondrial proteome?
abstract: This review will summarize proteomic methods that are useful in studying the role of mitochondria in cardioprotection. The strengths and weaknesses of some of the different approaches are discussed. We focus on the cardiac mitochondrial proteome with emphasis on changes associated with cell death and protection, and we summarize how proteomic data have contributed to addressing the role of mitochondria in cardioprotection.
authors.affiliation: NHLBI Proteomics Core, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Marjan
authors.initials: M
authors.lastname: Gucek
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Murphy
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D016923:Cell Death; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods
chemical_list: D002316:Cardiotonic Agents; D024101:Mitochondrial Proteins
references.citation: J Proteome Res. 2008 Jul;7(7):3054-9
references.pmid: 18543960
references.citation: Nat Biotechnol. 2009 Jun;27(6):557-9
references.pmid: 19483679
references.citation: Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H144-52
references.pmid: 19429812
references.citation: Mol Biotechnol. 2008 Nov;40(3):306-15
references.pmid: 18780189
references.citation: Circ Res. 2006 Jul 7;99(1):93-101
references.pmid: 16741159
references.citation: Cardiovasc Res. 2008 Oct 1;80(1):20-9
references.pmid: 18558627
references.citation: Circ Res. 2010 Jun 11;106(11):1681-91
references.pmid: 20413785
references.citation: Physiol Genomics. 2009 Jul 9;38(2):125-37
references.pmid: 19454556
references.citation: Cardiovasc Res. 2010 Oct 1;88(1):83-92
references.pmid: 20558438
references.citation: J Proteome Res. 2009 Jun;8(6):2838-50
references.pmid: 19290621
references.citation: Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2402-8
references.pmid: 16687609
references.citation: Circ Res. 2008 Oct 24;103(9):983-91
references.pmid: 18802025
references.citation: Biochemistry. 2006 Feb 28;45(8):2524-36
references.pmid: 16489745
references.citation: Nat Methods. 2007 Oct;4(10):798-806
references.pmid: 17901869
references.citation: J Pharmacol Exp Ther. 2005 Dec;315(3):1314-9
references.pmid: 16144979
references.citation: Mol Cell Proteomics. 2006 Apr;5(4):608-19
references.pmid: 16415296
references.citation: Circ Res. 2010 Feb 19;106(3):504-13
references.pmid: 20035080
references.citation: Biochem J. 2001 Jun 1;356(Pt 2):395-402
references.pmid: 11368766
references.citation: Arch Biochem Biophys. 2008 Jun 1;474(1):22-31
references.pmid: 18284913
references.citation: J Neurochem. 2003 Dec;87(6):1427-35
references.pmid: 14713298
references.citation: Circulation. 2008 Mar 4;117(9):1172-82
references.pmid: 18285568
references.citation: J Proteome Res. 2009 Oct;8(10):4665-75
references.pmid: 19694452
references.citation: Mol Cell. 2005 Jul 22;19(2):197-207
references.pmid: 16039589
references.citation: Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H496-9
references.pmid: 15764678
references.citation: J Mol Cell Cardiol. 2009 Feb;46(2):268-77
references.pmid: 19027023
references.citation: Biochem J. 2004 Sep 15;382(Pt 3):923-32
references.pmid: 15339253
references.citation: Circ Res. 2006 Oct 13;99(8):878-83
references.pmid: 16960097
references.citation: Nat Med. 2004 Nov;10(11):1200-7
references.pmid: 15489859
references.citation: Am J Physiol Cell Physiol. 2007 Feb;292(2):C689-97
references.pmid: 16928776
references.citation: Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2637-45
references.pmid: 18408135
references.citation: Circ Res. 2008 May 9;102(9):1082-90
references.pmid: 18356542
references.citation: Drug Metabol Drug Interact. 2006;21(3-4):245-58
references.pmid: 16841516
references.citation: Biochem J. 2006 Mar 15;394(Pt 3):627-34
references.pmid: 16371007
references.citation: J Biol Chem. 2004 Aug 27;279(35):36192-200
references.pmid: 15192091
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):726-31
references.pmid: 20080742
references.citation: Science. 2008 Sep 12;321(5895):1493-5
references.pmid: 18787169
references.citation: Proteomics. 2008 Oct;8(19):4066-82
references.pmid: 18763707
references.citation: Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2863-7
references.pmid: 11356646
references.citation: Mol Cell Proteomics. 2011 Feb;10(2):M110.000117
references.pmid: 20495213
references.citation: FASEB J. 2006 Aug;20(10):1715-7
references.pmid: 16809435
references.citation: Sci STKE. 2002 Oct 15;2002(154):pl16
references.pmid: 12381836
references.citation: Circ Res. 2009 Mar 27;104(6):796-804
references.pmid: 19229060
references.citation: Annu Rev Pharmacol Toxicol. 2009;49:199-221
references.pmid: 18834307
references.citation: Mitochondrion. 2004 Mar;3(4):187-204
references.pmid: 16120354
references.citation: Circ Res. 2006 Sep 29;99(7):706-14
references.pmid: 16946135
references.citation: Proteomics. 2007 Dec;7(24):4579-88
references.pmid: 18072194
references.citation: Circ Res. 2007 Nov 26;101(11):1155-63
references.pmid: 17916778
references.citation: ACS Chem Biol. 2010 Jan 15;5(1):105-19
references.pmid: 20047291
references.citation: Antioxid Redox Signal. 2008 Mar;10(3):579-99
references.pmid: 18052718
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6297-302
references.pmid: 19325130
references.citation: Science. 2009 Feb 6;323(5915):793-7
references.pmid: 19131594
references.citation: Physiol Rev. 2008 Apr;88(2):581-609
references.pmid: 18391174
references.citation: Electrophoresis. 2004 Aug;25(15):2520-5
references.pmid: 15300771
references.citation: Circ Res. 2002 Mar 8;90(4):390-7
references.pmid: 11884367
references.citation: Circ Res. 2010 Feb 5;106(2):285-96
references.pmid: 20133913
references.citation: Cell. 2003 Nov 26;115(5):629-40
references.pmid: 14651853
references.citation: Genes Dev. 2007 Apr 1;21(7):784-96
references.pmid: 17374715
references.citation: Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H75-91
references.pmid: 19855063
references.citation: J Clin Invest. 2010 May;120(5):1441-53
references.pmid: 20364086
references.citation: J Proteome Res. 2008 Sep;7(9):3789-802
references.pmid: 18707151
references.citation: Mol Cell. 2006 Aug;23(4):607-18
references.pmid: 16916647
references.citation: J Biol Chem. 2004 Apr 16;279(16):15805-13
references.pmid: 14739304
references.citation: Annu Rev Biomed Eng. 2009;11:49-79
references.pmid: 19400705
references.citation: Biochim Biophys Acta. 2009 Jul;1787(7):774-80
references.pmid: 19362067
references.citation: Proteomics. 2008 Apr;8(8):1564-75
references.pmid: 18348319
references.citation: Proteomics. 2006 May;6(10):3154-69
references.pmid: 16586429
references.citation: Circ Res. 2006 Feb 17;98(3):403-11
references.pmid: 16397145
references.citation: Biochim Biophys Acta. 2009 Jan;1789(1):45-57
references.pmid: 18603028
references.citation: Sci STKE. 2001 Jun 12;2001(86):pl1
references.pmid: 11752655
references.citation: Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E422-32
references.pmid: 18984854
references.citation: J Proteome Res. 2009 Jun;8(6):2679-95
references.pmid: 19351177
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9
references.pmid: 19528654
references.citation: Circ Res. 2003 May 2;92(8):873-80
references.pmid: 12663490
references.citation: Circulation. 2009 Jul 21;120(3):245-54
references.pmid: 19581491
references.citation: Biochem J. 2010 Aug 15;430(1):49-59
references.pmid: 20533907
references.citation: Mol Cell Proteomics. 2009 Jun;8(6):1324-37
references.pmid: 19208617
references.citation: Cardiovasc Res. 2005 Aug 1;67(2):234-44
references.pmid: 15919068
references.citation: J Biol Chem. 2010 Jul 30;285(31):23532-6
references.pmid: 20558729
references.citation: Oncogene. 2007 Apr 19;26(18):2606-20
references.pmid: 17072346
references.citation: Circ Res. 2005 Jul 8;97(1):78-85
references.pmid: 15961716
references.citation: J Clin Invest. 2004 Jun;113(11):1535-49
references.pmid: 15173880
references.citation: Clin Exp Pharmacol Physiol. 2008 Jul;35(7):812-9
references.pmid: 18346168
references.citation: J Physiol. 2009 Feb 15;587(Pt 4):851-72
references.pmid: 19103678