Clinical profile of hepatitis B virus chronic infection in patients of Brazilian liver reference units.
OBJECTIVE
To assess data about chronic forms of hepatitis B virus (HBV) infection in Brazilian reference units, the Brazilian Society of Hepatology (SBH) performed a survey, with its associates spread throughout the country.


METHODS
SBH members were contacted by electronic mail. They were asked for data from their liver units regarding chronically infected HBV patients between January 2005 and September 2007. All subjects with HBV surface antigenemia lasting more than 6 months were eligible. Patients who died after January 2005 were also included.


RESULTS
Data from 24 units of 17 cities (12 Brazilian states) were obtained. These corresponded to 3,913 patients. Mean age was 39 years, ranging from 1 to 84 years. The northern region had the lowest mean age (35 years) and the southern region the highest (43 years). Most of the sampled people were white; 1,448 of 3,614 patients had chronic hepatitis B. Most of them were HBeAg negative (1.4:1). There were 1,695 (46.9%) inactive carriers of 3,614 HBV-infected patients and other 69 (1.9%) were considered as having immune-tolerant status. Hepatitis D coinfection was common among the Amazonian sample (n = 369).


CONCLUSIONS
This large sample study shows important tendencies of chronic hepatitis B infection in Brazilian reference units, such as HBeAg-negative chronic hepatitis B cases overwhelming wild-type strains infected cases. Besides, hepatitis D occurs only among the Amazonian patients.
Galizzi F
João
J
Teixeira
Rosângela
R
Fonseca
José C F
JC
Souto
Francisco J D
FJ
Semin Liver Dis. 2003 Feb;23(1):47-58
12616450
Gastroenterology. 2004 Sep;127(3):756-63
15362032
Microbiol Mol Biol Rev. 2000 Mar;64(1):51-68
10704474
BMC Microbiol. 2008 Jan 22;8:11
18211717
Rev Soc Bras Med Trop. 2005 Nov-Dec;38(6):488-92
16410924
Acta Trop. 2008 Jun;106(3):149-55
18420172
Braz J Med Biol Res. 2006 Aug;39(8):1083-90
16906283
Am J Trop Med Hyg. 1989 Dec;41(6):726-31
2641647
N Engl J Med. 1997 Dec 11;337(24):1733-45
9392700
Virol J. 2005 Sep 28;2:82
16191199
Liver Int. 2006 Aug;26(6):636-42
16842318
J Viral Hepat. 2002 Jan;9(1):52-61
11851903
J Clin Microbiol. 2004 Jun;42(6):2455-60
15184419
Braz J Infect Dis. 2006 Oct;10(5):317-21
17293918