title: Inflammatory mediators gene polymorphisms in preeclampsia.
abstract: OBJECTIVE
  To assess a possible relation between proinflammatory mediators (IL-1R1, IL-12, IL-18, TLR-2, and TLR-4) gene polymorphisms and preeclampsia (PE).
  
  
  METHODS
  Genotyping was performed on 109 preeclamptic patients and 174 healthy fertile women with at least two previous successful pregnancies (controls). χ(2) or Fisher's exact test were used to compare genotype frequencies. The control group included 174 pregnant women matched by race to the study group.
  
  
  RESULTS
  Genotypic and allelic distributions for all six polymorphisms were similar between the study and control groups. IL-1R1 (PstI, rs2234650): p = 0.82 ; IL-12 (+1188, rs3212227): p = 0.93; IL-18 (-137, rs187238): p = 0.74 ; IL-18 (-607, rs1946519): p = 0.22; TLR-2 (+2258, rs5743708): p = 0.97; and TLR-4 (+896, rs4986790): p = 0.23.
  
  
  CONCLUSIONS
  The analyzed gene polymorphisms are not associated with PE.
authors.affiliation: Department of Obstetrics, Sao Paulo Federal University, Sao Paulo, Brazil.
authors.forename: Camila S
authors.initials: CS
authors.lastname: Franchim
authors.forename: Nelson
authors.initials: N
authors.lastname: Sass
authors.forename: Rosiane
authors.initials: R
authors.lastname: Mattar
authors.forename: Karen P T
authors.initials: KP
authors.lastname: Pendeloski
authors.forename: Lawrence Hsu
authors.initials: LH
authors.lastname: Lin
authors.forename: Maria R
authors.initials: MR
authors.lastname: Torloni
authors.forename: Silvia
authors.initials: S
authors.lastname: Daher
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D018836:Inflammation Mediators; D018664:Interleukin-12 / Q000235:genetics*; D020382:Interleukin-18 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: D018836:Inflammation Mediators; D020382:Interleukin-18; D017472:Receptors, Interleukin-1; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D018664:Interleukin-12