Prognostic value of baseline C-reactive protein levels in patients undergoing coronary revascularization.
BACKGROUND
C-reactive protein (CRP) is a lowly expressed marker for inflammatory response. This study aimed to evaluate the prognostic value of baseline CRP levels in patients undergoing coronary revascularization in the context of modern medical treatment.


METHODS
This was a retrospective study in a single center. Four hundred and fourteen patients were enrolled, who underwent coronary revascularization and received adequate medication for secondary prevention of coronary heart disease. The study compared the follow-up clinical outcomes between high level CRP group (CRP > 5 mg/L) and low level one. The median follow-up time was 551 days.


RESULTS
Compared with low CRP group, the relative risk (RR) of the major adverse cardiovascular and cerebral events (MACCE) in high CRP group was 5.131 (95%CI: 1.864-14.123, P = 0.002). There were no significant differences in death, myocardial infarction and stroke during the follow-up between two groups, but a higher risk of re-revascularization was found in high CRP group (RR 6.008, 95%CI: 1.667-21.665, P = 0.006). Cox regression analysis showed that only CRP level could contribute to MACCE during the follow-up. MACCE-free rate was much lower in high CRP group (Kaplan-Meier log-rank P < 0.001).


CONCLUSIONS
In the context of modern medical treatment, the baseline level of CRP is an independent predictor for long-term prognosis in patients with coronary revascularization.
Li
Xu
X
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Liu
Xiao-Hui
XH
Nie
Shao-Ping
SP
Du
Xin
X
Lü
Qiang
Q
Kang
Jun-Ping
JP
Dong
Jian-Zeng
JZ
Gu
Cheng-Xiong
CX
Huang
Fang-Jiong
FJ
Zhou
Yu-Jie
YJ
Chen
Fang
F
Lü
Shu-Zheng
SZ
Wu
Xue-Si
XS
Ma
Chang-Sheng
CS
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D012189:Retrospective Studies
D002097:C-Reactive Protein