title: Empowering self-renewal and differentiation: the role of mitochondria in stem cells.
abstract: Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote "stemness" in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
authors.affiliation: Section of Cardiology, Department of Medicine, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Ave. MC 6080, Chicago, IL 60637, USA. jrehman@medicine.bsd.uchicago.edu
authors.forename: Jalees
authors.initials: J
authors.lastname: Rehman
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species
references.citation: Nature. 2008 May 22;453(7194):524-8
references.pmid: 18432194
references.citation: Nat Rev Drug Discov. 2010 Jun;9(6):447-64
references.pmid: 20467424
references.citation: Circulation. 2010 Jan 19;121(2):197-9
references.pmid: 20048203
references.citation: Stem Cell Res. 2009 Sep-Nov;3(2-3):142-56
references.pmid: 19716358
references.citation: Stem Cells. 2008 Apr;26(4):960-8
references.pmid: 18218821
references.citation: Nat Rev Mol Cell Biol. 2008 Sep;9(9):725-9
references.pmid: 18698329
references.citation: Biochem Biophys Res Commun. 2006 Oct 6;348(4):1472-8
references.pmid: 16920071
references.citation: Stem Cells. 2009 Mar;27(3):559-67
references.pmid: 19259936
references.citation: Circulation. 2007 Sep 11;116(11 Suppl):I46-54
references.pmid: 17846325
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42
references.pmid: 20133848
references.citation: Circulation. 2003 Jun 3;107(21):2733-40
references.pmid: 12742992
references.citation: Stem Cells. 2010 Apr;28(4):721-33
references.pmid: 20201066
references.citation: Aging Cell. 2007 Dec;6(6):745-57
references.pmid: 17925003
references.citation: Clin Cancer Res. 2009 Nov 1;15(21):6479-83
references.pmid: 19861459
references.citation: Cell. 2007 May 4;129(3):465-72
references.pmid: 17482542
references.citation: J Cell Physiol. 2006 Jul;208(1):149-53
references.pmid: 16575916
references.citation: Nat Clin Pract Cardiovasc Med. 2007 Feb;4 Suppl 1:S60-7
references.pmid: 17230217
references.citation: Cell Stem Cell. 2007 Sep 13;1(3):253-8
references.pmid: 18371359
references.citation: J Cell Biochem. 2008 Feb 15;103(3):709-18
references.pmid: 17647265
references.citation: Cancer Cell. 2007 Jan;11(1):37-51
references.pmid: 17222789
references.citation: Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4783-8
references.pmid: 15772165
references.citation: Blood. 2007 Oct 15;110(8):3056-63
references.pmid: 17595331
references.citation: Stem Cells. 2010 Apr;28(4):661-73
references.pmid: 20073085
references.citation: Cell Stem Cell. 2009 Sep 4;5(3):237-41
references.pmid: 19716359
references.citation: Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2023-31
references.pmid: 17237240
references.citation: Nat Rev Genet. 2008 Feb;9(2):115-28
references.pmid: 18202695
references.citation: Cell Stem Cell. 2009 Aug 7;5(2):141-9
references.pmid: 19664987
references.citation: Nat Rev Mol Cell Biol. 2008 Apr;9(4):285-96
references.pmid: 18285802
references.citation: Trends Cell Biol. 2008 Apr;18(4):165-73
references.pmid: 18296052
references.citation: Am J Pathol. 2005 Sep;167(3):663-71
references.pmid: 16127147
references.citation: Stem Cell Rev Rep. 2009 Jun;5(2):140-58
references.pmid: 19521804
references.citation: Nat Rev Mol Cell Biol. 2007 Nov;8(11):870-9
references.pmid: 17928812
references.citation: J Cell Sci. 2007 Nov 15;120(Pt 22):4025-34
references.pmid: 17971411
references.citation: Circulation. 2009 Aug 4;120(5):408-16
references.pmid: 19620500
references.citation: Circ Res. 2009 Feb 27;104(4):e30-41
references.pmid: 19213953
references.citation: J Clin Invest. 2001 Aug;108(3):407-14
references.pmid: 11489934
references.citation: Cell. 2006 Oct 20;127(2):265-75
references.pmid: 17055429
references.citation: Curr Biol. 2006 Jul 25;16(14):R551-60
references.pmid: 16860735
references.citation: Cell. 2009 Apr 3;137(1):13-7
references.pmid: 19345179
references.citation: Aging Cell. 2009 Jun;8(3):296-310
references.pmid: 19627269
references.citation: Cell. 2005 Feb 25;120(4):483-95
references.pmid: 15734681
references.citation: Stem Cells. 2008 Sep;26(9):2201-10
references.pmid: 18599808
references.citation: Hum Mol Genet. 2008 Apr 15;17(R1):R23-7
references.pmid: 18632692
references.citation: Circulation. 2007 Nov 20;116(21):2409-19
references.pmid: 17984381
references.citation: Cell. 2008 Feb 22;132(4):661-80
references.pmid: 18295582
references.citation: Aging Cell. 2008 Jun;7(3):405-17
references.pmid: 18331617
references.citation: Nat Rev Cancer. 2008 Sep;8(9):705-13
references.pmid: 19143055
references.citation: Cell Prolif. 2009 Feb;42(1):63-74
references.pmid: 19143764