The language of histone crosstalk.
It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.
Lee
Jung-Shin
JS
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Smith
Edwin
E
Shilatifard
Ali
A
D002843:Chromatin / Q000378:metabolism*; D042421:Histone Code; D006657:Histones / Q000378:metabolism*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones
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