title: Ileocecal adenocarcinoma and ureteral transitional cell carcinoma with multiple sebaceous tumors and keratoacanthomas in a case of muir-torre syndrome.
abstract: Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS). We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) and ureteral transitional cell carcinoma who subsequently developed two sebaceous gland neoplasms and several keratoacanthomas, leading to the diagnosis of MTS. Our case highlights the clinical advantages of immunohistochemistry (IHC) in identifying mutations in the mismatch repair (MMR) genes responsible for both HNPCC and MTS. The importance of continued clinical suspicion in the dermatological assessment of patients with sebaceous neoplasms is emphasized.
authors.affiliation: Department of Dermatology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USApsu.edu.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Lynch
authors.forename: Bryan E
authors.initials: BE
authors.lastname: Anderson
references.citation: Am J Surg Pathol. 2008 Jun;32(6):936-42
references.pmid: 18551751
references.citation: Histopathology. 2010 Jan;56(1):133-47
references.pmid: 20055911
references.citation: Clin Exp Dermatol. 2009 Oct;34(7):e399-400
references.pmid: 19549240
references.citation: J Cutan Pathol. 2009 Jun;36(6):613-9
references.pmid: 19515040
references.citation: Arch Intern Med. 1981 Apr;141(5):607-11
references.pmid: 7224741
references.citation: Lancet Oncol. 2005 Dec;6(12):980-7
references.pmid: 16321766
references.citation: Fam Cancer. 2007;6(3):317-21
references.pmid: 17323113
references.citation: Br J Surg. 1967 Mar;54(3):191-5
references.pmid: 6020987
references.citation: Fam Cancer. 2008;7(3):255-7
references.pmid: 18236172
references.citation: Arch Dermatol. 1968 Nov;98(5):549-51
references.pmid: 5684233