title: [¹¹C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results.
abstract: OBJECTIVE
  Based on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [(11)C]acetate PET.
  
  
  METHODS
  Two male patients were investigated 3 and 12 weeks after hip arthroplasty with muscle [(11)C]acetate PET/CT performed at rest and exercise. Median muscle SUV(mean) were calculated on three non-consecutive transverse PET slices.
  
  
  RESULTS
  The four exercise PET/CT showed, compared with rest, consistent increase in [(11)C]acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12 weeks after surgery, but four muscles showed only minor activity increase at 3 weeks. At 3 months, functional recovery of the latter four muscles was observed.
  
  
  CONCLUSIONS
  Consistent increase in [(11)C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation.
authors.affiliation: Service of Nuclear Medicine, University Hospital of Geneva, Geneva, Switzerland. Franz.Buchegger@hcuge.ch
authors.forename: Franz
authors.initials: F
authors.lastname: Buchegger
authors.forename: Osman
authors.initials: O
authors.lastname: Ratib
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Willi
authors.forename: Charles
authors.initials: C
authors.lastname: Steiner
authors.forename: Yann
authors.initials: Y
authors.lastname: Seimbille
authors.forename: Habib
authors.initials: H
authors.lastname: Zaidi
authors.forename: Véronique
authors.initials: V
authors.lastname: Graf
authors.forename: Robin
authors.initials: R
authors.lastname: Peter
authors.forename: Maximilien
authors.initials: M
authors.lastname: Jung
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D002250:Carbon Radioisotopes; D005081:Exercise Therapy; D006615:Hip / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D020127:Recovery of Function / Q000502:physiology; D012146:Rest; D014057:Tomography, X-Ray Computed
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes
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