title: Beneficial effect of Eucommia polysaccharides on systemic lupus erythematosus-like syndrome induced by Campylobacter jejuni in BALB/c mice.
abstract: The stem bark of Eucommia ulmoides Oliv. is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia in traditional Chinese medicine. This study was to determine whether the crude polysaccharides (EUPs) isolated from the stem bark of E. ulmoides had beneficial effects on lupus-like syndrome in mice. BALB/c mice were immunized with CJ-S(131) in Freund's complete adjuvant on day 0, and then boosted on day 14. EUPs 15 or 30 mg kg(-1)·day(-1), or prednisone 5 mg kg(-1)·day(-1) was given to BALB/c mice intragastrically from day 0 to 34. Treatment with EUPs 15 or 30 mg kg(-1)·day(-1) for 35 days protected kidney from glomerular injury with reduced immunoglobulin deposition and lowered proteinuria. The increased production of serum autoantibodies and total immunoglobulin G (IgG) was also inhibited. These findings suggested that Eucommia polysaccharides had a beneficial effect on systemic lupus erythematosus-like syndrome induced by CJ-S(131) in BALB/c mice.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China.
authors.forename: Long
authors.initials: L
authors.lastname: Jiang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhu
authors.forename: Hong-Ye
authors.initials: HY
authors.lastname: Di
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Yun-Yi
authors.initials: YY
authors.lastname: Zhang
authors.forename: Dao-Feng
authors.initials: DF
authors.lastname: Chen
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D016123:Campylobacter jejuni / Q000276:immunology / Q000472:pathogenicity; D051056:Complement Inactivating Agents / Q000302:isolation & purification / Q000627:therapeutic use; D004195:Disease Models, Animal; D031283:Eucommiaceae / Q000737:chemistry; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D013577:Syndrome
chemical_list: D001323:Autoantibodies; D051056:Complement Inactivating Agents; D007074:Immunoglobulin G; D011134:Polysaccharides
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