Biological markers and Alzheimer disease: a canadian perspective.
Decreased beta-amyloid(1-42) and increased phospho-tau protein levels in the cerebrospinal fluid (CSF) are currently the most accurate chemical neurodiagnostics of sporadic Alzheimer disease (AD). A report (2007) of the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (2006) recommended that biological markers should not be currently requisitioned by primary care physicians in the routine investigation of subjects with memory complaints. Consideration for such testing should prompt patient referral to a specialist engaged in dementia evaluations or a Memory Clinic. The specialist should consider having CSF biomarkers (beta-amyloid(1-42) and phospho-tau) measured at a reputable facility in restricted cases presenting with atypical features and diagnostic confusion, but not as a routine procedure in all individuals with typical sporadic AD phenotypes. We submit that developments in the field of AD biomarker discovery since publication of the 3rd CCCDTD consensus data do not warrant revision of the 2007 recommendations.
Schipper
Hyman M
HM
Department of Neurology and Neurosurgery, Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote St. Catherine Rd. Montreal, QC, Canada H3T 1E2.
Arch Neurol. 2003 Dec;60(12):1696-702
14676043
Alzheimers Dement. 2005 Oct;1(2):119-20
19595841
Neurobiol Aging. 1998 Mar-Apr;19(2):161-3
9558155
Neurology. 2005 Apr 12;64(7):1294-7
15824371
Neurobiol Dis. 2009 Aug;35(2):157-64
18938247
Lancet Neurol. 2009 Jul;8(7):619-27
19523877
Neurology. 2002 Aug 27;59(4):627-9
12196665
Lancet Neurol. 2003 Oct;2(10):605-13
14505582
Neurosci Lett. 2003 Mar 20;339(2):172-4
12614922
Neurobiol Aging. 2007 Dec;28(12):1795-809
16979800
Alzheimers Dement. 2007 Oct;3(4):325-32
19595953
Neurobiol Aging. 1998 Mar-Apr;19(2):109-16
9558143
Biol Psychiatry. 2004 Mar 1;55(5):524-30
15023581
Int Psychogeriatr. 2003;15 Suppl 1:89-97
16191223
Nat Rev Neurol. 2010 Mar;6(3):131-44
20157306
J Alzheimers Dis. 2000 Nov;2(3-4):199-206
12214084
J Clin Epidemiol. 1990;43(9):891-905
2145399
Neurosci Lett. 2000 May 5;285(1):49-52
10788705
Control Clin Trials. 1996 Feb;17(1):1-12
8721797
Clin Chim Acta. 2003 Jun;332(1-2):1-10
12763273
J Neurol Sci. 1996 Sep 15;141(1-2):65-8
8880695
Front Biosci. 2002 Apr 01;7:d997-1006
11897565
Gene Regul Syst Bio. 2007 Dec 20;1:263-74
19936094
Nature. 2009 Oct 15;461(7266):916-22
19829371
Scand J Clin Lab Invest. 2009;69(1):22-5
19199127
Neurology. 2010 Jan 19;74(3):201-9
20042704
CMAJ. 1999 Jun 15;160(12):1738-42
10410640
CNS Neurosci Ther. 2009 Winter;15(4):358-74
19840034
Exp Neurol. 2000 Nov;166(1):201-3
11031097
Mov Disord. 2003 Feb;18(2):186-90
12539213
Neurobiol Dis. 2009 Aug;35(2):128-40
19010417
Neurobiol Aging. 2002 Jul-Aug;23(4):517-9; discussion 521-2
12009499
Arch Neurol. 2003 Sep;60(9):1218-22
12975286
Brain Res Rev. 2009 Oct;61(2):69-80
19464319
Alzheimer Dis Assoc Disord. 2005 Oct-Dec;19(4):220-5
16327349
Arch Gen Psychiatry. 2004 Jan;61(1):95-102
14706948
Neurobiol Aging. 2011 May;32(5):778-90
19482376
Med Sci Monit. 2003 Nov;9(11):CR484-8
14586274
JAMA. 2009 Jul 22;302(4):385-93
19622817
Ageing Res Rev. 2009 Oct;8(4):285-305
19376275
NeuroRx. 2004 Apr;1(2):213-25
15717022
JAMA. 2003 Apr 23-30;289(16):2094-103
12709467
Neurosci Lett. 2003 Mar 20;339(2):99-102
12614904
J Neural Transm (Vienna). 2003 Oct;110(10):1149-60
14523627
J Neurol Neurosurg Psychiatry. 2006 Jan;77(1):89-91
16361602
Neurosci Lett. 2001 Jan 19;297(3):187-90
11137759
Neurosci Lett. 1999 Jan 8;259(2):133-5
10025576
Neurobiol Aging. 1998 Mar-Apr;19(2):145-7
9558151
Neurol Sci. 2001 Feb;22(1):77-8
11487210
Neurocase. 2005 Feb;11(1):32-9
15804922
Dement Geriatr Cogn Disord. 2005;19(2-3):164-70
15637452
Arch Neurol. 2000 Jan;57(1):100-5
10634455
Neurology. 2004 May 11;62(9):1580-4
15136685
Ann Neurol. 2005 May;57(5):721-9
15852395
Transl Res. 2008 Sep;152(3):103-12
18774539
Mol Chem Neuropathol. 1995 Dec;26(3):231-45
8748926
J Alzheimers Dis. 2009;17(2):391-7
19363272
Neurology. 1999 Oct 22;53(7):1488-94
10534256
Mol Psychiatry. 2004 Jul;9(7):705-10
14699432
Neurobiol Aging. 2003 Jul-Aug;24(4):521-36
12714109
Alzheimers Dement. 2007 Oct;3(4):262-5
19595947
CMAJ. 1999 Jun 15;160(12 Suppl):S1-15
10410645
Electrophoresis. 2002 Jul;23(14):2247-51
12210229
Neurology. 1999 May 12;52(8):1555-62
10331678
J Mol Neurosci. 2004;23(1-2):115-22
15126697
Dement Geriatr Cogn Disord. 2009;28(4):281-7
19828948
Exp Neurol. 2003 Sep;183(1):74-80
12957490
Biomark Med. 2007 Oct;1(3):375-85
20477381
Arch Neurol. 2004 May;61(5):716-20
15148149
Mol Psychiatry. 2003 Mar;8(3):343-7
12660807
Proteomics. 2003 Nov;3(11):2240-8
14595822
Neurology. 2000 Mar 14;54(5):1099-102
10720281
J Intern Med. 2004 Sep;256(3):205-23
15324364
Eur Arch Psychiatry Clin Neurosci. 2003 Apr;253(2):100-2
12799749
Arch Neurol. 2002 Nov;59(11):1729-34
12433260