title: The correlation of extent and grade of inflammation with serum PSA levels in patients with IV prostatitis.
abstract: OBJECTIVE
  The inflammation was categorized more profoundly, using the standardized histopathological classification system for chronic prostatitis of NIH, to determine the influence of prostatic inflammation on serum PSA levels.
  
  
  METHODS
  The study included 120 patients who underwent transperineal ultrasound-guided prostate biopsy. The patients were divided into groups using 3 grades for the extent, the location and the aggressiveness of prostate inflammation. The serum tPSA levels, fPSA levels, %fPSA, and PSAD in each group were compared.
  
  
  RESULTS
  Of 120 patients, 80 with benign prostatic tissue in their biopsy specimens met the inclusion criteria, excluding 40 cases with prostate cancer. The inflammation was present in 46(57.5%) of 80 cases. The extent of inflammation correlated positively with the total PSA level (r = 0.6, P < 0.001), fPSA (r = 0.5, P = 0.001) and PSAD (r = 0.6, P < 0.001). The grade of inflammation correlated positively with the total PSA level (r = 0.5, P < 0.001), fPSA (r = 0.4, P = 0.008) and PSAD (r = 0.7, P < 0.001). A negative correlation was found between the grade of inflammation and %fPSA (r = -0.4, P = 0.013).
  
  
  CONCLUSIONS
  If the elevation of serum PSA is thought to be caused by asymptomatic prostatitis with high aggressiveness score in BPH patients without clinical prostatitis, it might prevent unnecessary repeated biopsies.
authors.affiliation: Department of Urology, Beijing Jishuitan Hospital, 100035 Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Gui-Zhong
authors.forename: Man
authors.initials: M
authors.lastname: Libo
authors.forename: Huang
authors.initials: H
authors.lastname: Guanglin
authors.forename: Wang
authors.initials: W
authors.lastname: Jianwei
mesh_terms: D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011472:Prostatitis / Q000097:blood* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D017430:Prostate-Specific Antigen
references.citation: Urol Int. 2008;80(2):186-92
references.pmid: 18362491
references.citation: Eur Urol. 2000 Apr;37(4):404-12
references.pmid: 10765070
references.citation: Urol Int. 2003;71(2):160-4
references.pmid: 12890953
references.citation: J Urol. 2000 Sep;164(3 Pt 1):722-5
references.pmid: 10953133
references.citation: Prostate Cancer Prostatic Dis. 2008;11(2):148-52
references.pmid: 17637759
references.citation: Urology. 2007 Oct;70(4):743-7
references.pmid: 17991548
references.citation: Cytokine. 2008 Aug;43(2):194-9
references.pmid: 18572414
references.citation: Urology. 2002 Dec;60(6 Suppl):5-6; discussion 6-7
references.pmid: 12521577
references.citation: Urology. 2003 Nov;62(5):854-9
references.pmid: 14624908
references.citation: Eur Urol. 2008 Dec;54(6):1379-84
references.pmid: 18036719
references.citation: J Urol. 1991 May;145(5):984-7
references.pmid: 2016815
references.citation: Int Urol Nephrol. 2007;39(3):859-63
references.pmid: 17111077
references.citation: J Urol. 1999 Aug;162(2):293-306
references.pmid: 10411025
references.citation: Int Urol Nephrol. 2004;36(4):549-53
references.pmid: 15787334
references.citation: Urology. 2009 Aug;74(2):340-4
references.pmid: 19464042
references.citation: Urology. 2004 Dec;64(6):1098-101
references.pmid: 15596176
references.citation: J Urol. 1998 Apr;159(4):1234-7
references.pmid: 9507843
references.citation: Am J Surg Pathol. 1992 Oct;16(10):975-81
references.pmid: 1415905
references.citation: Urology. 2008 Dec;72(6):1194-7
references.pmid: 18829081
references.citation: Cancer. 1991 Oct 1;68(7):1592-9
references.pmid: 1716510
references.citation: Eur Urol. 2000 May;37(5):537-40
references.pmid: 10765091
references.citation: Curr Urol Rep. 2009 Jul;10(4):302-6
references.pmid: 19570492
references.citation: Cancer. 1996 May 15;77(10):2162-6
references.pmid: 8640686
references.citation: J Urol. 1997 Apr;157(4):1301-3
references.pmid: 9120926