title: TIP39 modulates effects of novelty-induced arousal on memory.
abstract: Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide localized to neural circuits subserving emotional processing. Recent work showed that mice with null mutation for the gene coding TIP39 (TIP39-KO mice) display increased susceptibility to environmental provocation. Based on this stressor-dependent phenotype, the neuroanatomical distribution of TIP39, and knowledge that novelty-induced arousal modulates memory functions via noradrenergic activation, we hypothesized that exposure to a novel environment differently affects memory performance of mice with or without TIP39 signaling, potentially by differences in sensitivity of the noradrenergic system. We tested TIP39-KO mice and mice with null mutation of its receptor, the parathyroid hormone 2 receptor (PTH2-R), in tasks of short-term declarative and social memory (object recognition and social recognition tests, respectively), and of working memory (Y-maze test) under conditions of novelty-induced arousal or acclimation to the test conditions. Mice lacking TIP39 signaling showed memory impairment selectively under conditions of novelty-induced arousal. Acute administration of a PTH2-R antagonist in wild-type mice had a similar effect. The restoration of memory functions in TIP39-KO mice after injection of a β-adrenoreceptor-blocker, propranolol, suggested involvement of the noradrenergic system. Collectively, these results suggest that the TIP39/PTH2-R system modulates the effects of novelty exposure on memory performance, potentially by acting on noradrenergic signaling.
authors.affiliation: Section on Fundamental Neuroscience, National Institute of Mental Health/National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: L
authors.initials: L
authors.lastname: Coutellier
authors.forename: A
authors.initials: A
authors.lastname: Logemann
authors.forename: J
authors.initials: J
authors.lastname: Kuo
authors.forename: M
authors.initials: M
authors.lastname: Rusnak
authors.forename: T B
authors.initials: TB
authors.lastname: Usdin
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D005556:Form Perception / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; D044183:Receptor, Parathyroid Hormone, Type 2 / Q000037:antagonists & inhibitors / Q000235:genetics; D021641:Recognition, Psychology / Q000502:physiology; D012919:Social Behavior; D013564:Sympathetic Nervous System / Q000502:physiology; D033921:Vesicular Transport Proteins / Q000235:genetics* / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; D044183:Receptor, Parathyroid Hormone, Type 2; C412229:Tfip11 protein, mouse; D033921:Vesicular Transport Proteins; D011433:Propranolol
references.citation: Nat Rev Neurosci. 2009 Mar;10(3):211-23
references.pmid: 19190638
references.citation: Neurosci Biobehav Rev. 2002 Jan;26(1):91-104
references.pmid: 11835987
references.citation: Prog Brain Res. 2008;167:79-97
references.pmid: 18037008
references.citation: Learn Mem. 2009 Sep 30;16(10):625-34
references.pmid: 19794188
references.citation: Brain Res. 2003 Dec 19;994(1):107-14
references.pmid: 14642454
references.citation: Prog Brain Res. 1975;42:151-62
references.pmid: 172960
references.citation: Neuropsychopharmacology. 2008 Jan;33(2):394-405
references.pmid: 17429409
references.citation: Behav Brain Res. 1988 Nov 1;31(1):47-59
references.pmid: 3228475
references.citation: Genes Brain Behav. 2008 Nov;7(8):933-42
references.pmid: 18700839
references.citation: Eur J Pharmacol. 2010 Jan 10;626(1):9-17
references.pmid: 19837050
references.citation: Nat Protoc. 2009;4(11):1574-81
references.pmid: 19816420
references.citation: Nat Neurosci. 1999 Nov;2(11):941-3
references.pmid: 10526330
references.citation: Neurosci Biobehav Rev. 1994 Winter;18(4):497-518
references.pmid: 7708363
references.citation: Peptides. 2007 Apr;28(4):887-92
references.pmid: 17207559
references.citation: N Engl J Med. 1981 Aug 27;305(9):500-6
references.pmid: 6114433
references.citation: Behav Brain Res. 2003 May 15;141(2):229-36
references.pmid: 12742260
references.citation: Neuropsychopharmacology. 2006 Nov;31(11):2405-14
references.pmid: 16482087
references.citation: Acta Psychol (Amst). 2008 Mar;127(3):513-31
references.pmid: 17900515
references.citation: Nat Rev Neurosci. 2008 Feb;9(2):148-58
references.pmid: 18209732
references.citation: Nat Rev Neurosci. 2009 Jun;10(6):410-22
references.pmid: 19455173
references.citation: Curr Opin Neurobiol. 2002 Apr;12(2):205-10
references.pmid: 12015238
references.citation: Curr Opin Neurol. 2006 Dec;19(6):607-12
references.pmid: 17102701
references.citation: Prog Neurobiol. 2010 Jan 11;90(1):29-59
references.pmid: 19857544
references.citation: Clin Pharmacol Ther. 1986 Apr;39(4):361-8
references.pmid: 3956052
references.citation: Learn Mem. 2008 Aug 06;15(8):551-64
references.pmid: 18685145
references.citation: Neurosci Biobehav Rev. 2009 Jun;33(6):773-83
references.pmid: 19111570
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14602-7
references.pmid: 9405659
references.citation: Physiol Behav. 1988;44(2):273-80
references.pmid: 3237834
references.citation: Endocrinology. 2008 Sep;149(9):4292-300
references.pmid: 18483145
references.citation: Brain Res. 1977 May 20;127(1):1-21
references.pmid: 67877
references.citation: Neurobiol Learn Mem. 2008 Oct;90(3):576-9
references.pmid: 18657626
references.citation: Exp Neurol. 2008 May;211(1):67-84
references.pmid: 18316078
references.citation: Neuroscience. 2009 Dec 1;164(2):415-23
references.pmid: 19720115
references.citation: Eur Heart J. 1987 Dec;8 Suppl M:9-14
references.pmid: 2897304
references.citation: J Comp Neurol. 2007 Jun 1;502(4):563-83
references.pmid: 17394159
references.citation: Neuroreport. 2004 Apr 9;15(5):881-5
references.pmid: 15073536
references.citation: Biol Psychiatry. 2004 Sep 15;56(6):381-5
references.pmid: 15364034
references.citation: Trends Neurosci. 2002 Jul;25(7):336-40
references.pmid: 12079755
references.citation: Biol Psychiatry. 2005 Jun 1;57(11):1377-84
references.pmid: 15950011
references.citation: Neuroscience. 2003;122(4):1093-105
references.pmid: 14643775
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):853-8
references.pmid: 14711996
references.citation: Lancet Neurol. 2003 Aug;2(8):463-72
references.pmid: 12878434
references.citation: Trends Neurosci. 1998 Jul;21(7):294-9
references.pmid: 9683321