Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.
Two series of some new 2,4,6-trisubstituted-quinazoline derivatives were prepared and screened for their analgesic, anti-inflammatory activity and acute toxicity. Four compounds were more potent analgesic agents than the reference drug Indomethacin and thirteen compounds showed significant anti-inflammatory activity. Seven compounds showed combined ability to inhibit both pain and inflammation. Compounds tested for acute toxicity showed no toxic symptoms or mortality rates 24 h post-administration implying their good safety margin.
Alafeefy
Ahmed M
AM
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box 2457, Saudi Arabia. sihmaid@students.latrobe.edu.au
Kadi
Adnan A
AA
Al-Deeb
Omar A
OA
El-Tahir
Kamal E H
KE
Al-Jaber
Nabila A
NA
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011799:Quinazolines