title: Exploratory study on oxygen consumption on-kinetics during treadmill walking in women with systemic lupus erythematosus.
abstract: OBJECTIVE
  To determine whether oxygen consumption (V o(2)) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls.
  
  
  METHODS
  Exploratory case-control study.
  
  
  METHODS
  Medical school exercise physiology laboratory.
  
  
  METHODS
  Convenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10).
  
  
  METHODS
  None.
  
  
  METHODS
  V o(2) on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs).
  
  
  RESULTS
  Time to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE.
  
  
  CONCLUSIONS
  V o(2) on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.
authors.affiliation: George Mason University, Fairfax, VA, USA. rkeyser@gmu.edu
authors.forename: Randall E
authors.initials: RE
authors.lastname: Keyser
authors.forename: Violeta
authors.initials: V
authors.lastname: Rus
authors.forename: Jamal A
authors.initials: JA
authors.lastname: Mikdashi
authors.forename: Barry S
authors.initials: BS
authors.lastname: Handwerger
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold; D016022:Case-Control Studies; D005080:Exercise Test; D017079:Exercise Tolerance; D005221:Fatigue / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology* / Q000534:rehabilitation*; D008875:Middle Aged; D010101:Oxygen Consumption
references.citation: J Appl Physiol (1985). 1992 May;72(5):1764-72
references.pmid: 1601784
references.citation: J Appl Physiol (1985). 1996 Dec;81(6):2500-8
references.pmid: 9018498
references.citation: Eur J Appl Physiol Occup Physiol. 1975 Aug 15;34(3):141-8
references.pmid: 1181176
references.citation: J Lab Clin Med. 1969 Sep;74(3):369-79
references.pmid: 4896818
references.citation: J Appl Physiol (1985). 2008 Aug;105(2):575-80
references.pmid: 18483168
references.citation: Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003534
references.pmid: 16034902
references.citation: J Appl Physiol (1985). 2007 Sep;103(3):771-8
references.pmid: 17495116
references.citation: Br J Sports Med. 2003 Aug;37(4):315-20
references.pmid: 12893716
references.citation: J Physiol. 2006 Dec 15;577(Pt 3):985-96
references.pmid: 16990406
references.citation: Exp Physiol. 2000 Jan;85(1):109-16
references.pmid: 10662900
references.citation: J Lab Clin Med. 1968 Jun;71(6):919-33
references.pmid: 5654777
references.citation: J Rheumatol. 2002 Mar;29(3):474-81
references.pmid: 11908559
references.citation: Med Sci Sports. 1979 Winter;11(4):338-44
references.pmid: 530025
references.citation: Arch Physiol Biochem. 2003 Dec;111(5):461-6
references.pmid: 16026035
references.citation: Aviat Space Environ Med. 1990 Mar;61(3):236-9
references.pmid: 2317178
references.citation: Arthritis Rheum. 2005 Dec 15;53(6):838-44
references.pmid: 16342102
references.citation: J Rheumatol. 1990 Nov;17(11):1450-2
references.pmid: 2273484
references.citation: J Appl Physiol (1985). 1995 Jun;78(6):2228-34
references.pmid: 7665422
references.citation: Med Sci Sports Exerc. 2002 Oct;34(10):1563-9
references.pmid: 12370556
references.citation: Am Heart J. 1973 Apr;85(4):546-62
references.pmid: 4632004
references.citation: J Rheumatol. 1999 Dec;26(12):2591-4
references.pmid: 10606367
references.citation: Rheumatology (Oxford). 2000 Nov;39(11):1249-54
references.pmid: 11085805
references.citation: Int J Tissue React. 1986;8(2):111-7
references.pmid: 3700003
references.citation: J Appl Physiol (1985). 2001 Aug;91(2):891-6
references.pmid: 11457807
references.citation: J Appl Physiol. 1971 Feb;30(2):261-3
references.pmid: 5539892
references.citation: Thorax. 1995 Aug;50(8):829-33
references.pmid: 7570432
references.citation: J Physiol. 2004 Dec 1;561(Pt 2):623-35
references.pmid: 15358808
references.citation: J Appl Physiol (1985). 2003 Dec;95(6):2537-43
references.pmid: 14600163
references.citation: J Appl Physiol (1985). 2005 Dec;99(6):2463-8; author reply 2468-9
references.pmid: 16288106
references.citation: Arch Phys Med Rehabil. 2003 Nov;84(11):1595-603
references.pmid: 14639557
references.citation: Arch Neurol. 1989 Oct;46(10):1121-3
references.pmid: 2803071
references.citation: Arthritis Rheum. 2003 Feb 15;49(1):16-22
references.pmid: 12579589
references.citation: Rheumatology (Oxford). 2003 Sep;42(9):1050-4
references.pmid: 12730519
references.citation: Sports Med. 1999 May;27(5):313-27
references.pmid: 10368878
references.citation: J Appl Physiol (1985). 2004 Mar;96(3):1033-8
references.pmid: 14657038
references.citation: Int J Sports Med. 2006 Jul;27(7):517-25
references.pmid: 16802246
references.citation: Circulation. 1987 Dec;76(6 Pt 2):VI18-28
references.pmid: 3119250
references.citation: Circulation. 1987 Dec;76(6 Pt 2):VI29-39
references.pmid: 3315297
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun;52(6):1506-13
references.pmid: 6809716
references.citation: Circulation. 1974 Apr;49(4):696-702
references.pmid: 4817710
references.citation: Med Sci Sports Exerc. 1996 Oct;28(10):1221-8
references.pmid: 8897377
references.citation: Med Sci Sports Exerc. 2010 Jan;42(1):127-34
references.pmid: 20010121
references.citation: Med Sci Sports Exerc. 2008 Mar;40(3):462-74
references.pmid: 18379208
references.citation: J Appl Physiol (1985). 2000 Sep;89(3):899-907
references.pmid: 10956332
references.citation: Aviat Space Environ Med. 1986 Jan;57(1):17-22
references.pmid: 3942565
references.citation: Diabetes Care. 1999 Oct;22(10):1640-6
references.pmid: 10526728
references.citation: J Clin Endocrinol Metab. 2004 Dec;89(12):6198-207
references.pmid: 15579778
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):921-9
references.pmid: 6806226
references.citation: J Rheumatol. 1995 Aug;22(8):1483-7
references.pmid: 7473470
references.citation: Arthritis Rheum. 2008 Jan;58(1):26-35
references.pmid: 18163497
references.citation: Med Sci Sports Exerc. 2003 Jul;35(7):1108-17
references.pmid: 12840630
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1978 Jan;44(1):90-2
references.pmid: 627505
references.citation: Arthritis Rheum. 2007 Dec 15;57(8):1348-57
references.pmid: 18050225
references.citation: Eur J Appl Physiol. 2004 May;91(5-6):545-54
references.pmid: 14648126
references.citation: Arthritis Rheum. 1982 Nov;25(11):1271-7
references.pmid: 7138600
references.citation: J Card Fail. 2001 Dec;7(4):302-10
references.pmid: 11782852
references.citation: Lupus. 2008 Feb;17(2):100-4
references.pmid: 18250132
references.citation: Eur J Appl Physiol Occup Physiol. 1991;63(2):94-100
references.pmid: 1748111
references.citation: J Rheumatol. 1990 Feb;17(2):210-9
references.pmid: 2319520
references.citation: Eur J Appl Physiol. 2004 May;91(5-6):669-76
references.pmid: 14652761
references.citation: J Appl Physiol (1985). 1986 Jun;60(6):2020-7
references.pmid: 3087938
references.citation: Med Sci Sports Exerc. 1994 Nov;26(11):1354-8
references.pmid: 7837956
references.citation: J Appl Physiol (1985). 2010 Apr;108(4):913-22
references.pmid: 20150562
references.citation: Med J Aust. 1964 Aug 22;2:320-1
references.pmid: 14194486
references.citation: Lab Invest. 1970 Apr;22(4):301-8
references.pmid: 5429531
references.citation: Med Sci Sports Exerc. 1994 Nov;26(11):1319-26
references.pmid: 7741865
references.citation: Hum Pathol. 1982 Aug;13(8):745-57
references.pmid: 7049895
references.citation: Chest. 1992 May;101(5 Suppl):211S-218S
references.pmid: 1576837
references.citation: Biophys J. 1990 Mar;57(3):485-98
references.pmid: 2306498
references.citation: Arch Phys Med Rehabil. 2003 Dec;84(12):1831-8
references.pmid: 14669191
references.citation: Med Sci Sports Exerc. 1995 Sep;27(9):1292-301
references.pmid: 8531628
references.citation: N Engl J Med. 1999 Jan 28;340(4):272-7
references.pmid: 9920951
references.citation: Eur Heart J. 1984 Sep;5(9):752-5
references.pmid: 6499863