Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms.
In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.
Xiao
Youli
Y
Department of Chemistry, Boston University, MA 02215, USA.
Nyland
Rodney L
RL
Meyers
Caren L Freel
CL
Liu
Pinghua
P
D019883:Alkyl and Aryl Transferases / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D000460:Chlorophyta / Q000201:enzymology*; D004852:Epoxy Compounds / Q000378:metabolism*; D004896:Erythritol / Q000031:analogs & derivatives; D010755:Organophosphates / Q000378:metabolism*; D010944:Plants / Q000201:enzymology*; D015398:Signal Transduction; D014994:Xylose / Q000031:analogs & derivatives* / Q000378:metabolism
C467061:4-hydroxy-3-methyl-2-butenyl diphosphate; D004852:Epoxy Compounds; D010755:Organophosphates; C492551:deoxyxylulose phosphate; C443879:methyl-D-erythritol 2,4-cyclodiphosphate; D014994:Xylose; D019883:Alkyl and Aryl Transferases; D004896:Erythritol
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