title: Atypical conduction aphasia and the right hemisphere: Cross-hemispheric plasticity of phonology in a developmentally dyslexic and dysgraphic patient with early left frontal damage.
abstract: We report the rare case of a patient, JNR, with history of mixed handedness, developmental dyslexia, dysgraphia, and attentional deficits associated with a Klippel-Trenaunay syndrome and a small subcortical frontal lesion involving the left arcuate fasciculus. In adulthood, he suffered a large right perisylvian stroke and developed atypical conduction aphasia with deficits in input and output phonological processing and poor auditory-verbal short-term memory. Lexical-semantic processing for single words was intact, but he was unable to access meaning in sentence comprehension and repetition. Reading and writing deficits worsened after the stroke and he presented a combination of developmental and acquired dysgraphia and dyslexia with mixed lexical and phonological processing deficits. This case suggest that a small lesion sustained prenatally or early in life could induce a selective rightward shift of phonology sparing the standard left hemisphere lateralisation of lexical-semantic functions.
authors.affiliation: Centro de Investigaciones Médico-Sanitarias (CIMES), C/Marques de Beccaria 3, Málaga, Spain. mbt@uma.es
authors.forename: Marcelo L
authors.initials: ML
authors.lastname: Berthier
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Dávila
authors.forename: Natalia
authors.initials: N
authors.lastname: García-Casares
authors.forename: Cristina
authors.initials: C
authors.lastname: Green
authors.forename: Rocío
authors.initials: R
authors.lastname: Juárez
authors.forename: Rafael
authors.initials: R
authors.lastname: Ruiz-Cruces
authors.forename: J
authors.initials: J
authors.lastname: Pablo Lara
authors.forename: M A
authors.initials: MA
authors.lastname: Barbancho
mesh_terms: D000328:Adult; D000381:Agraphia / Q000209:etiology / Q000503:physiopathology*; D018886:Aphasia, Conduction / Q000209:etiology / Q000503:physiopathology*; D004410:Dyslexia / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007715:Klippel-Trenaunay-Weber Syndrome / Q000503:physiopathology; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D009483:Neuropsychological Tests; D010700:Phonetics; D012660:Semantics; D020521:Stroke / Q000150:complications