Intracranial volume and whole brain volume in infants with unicoronal craniosynostosis.
OBJECTIVE
Craniosynostosis has been hypothesized to result in alterations of the brain and cerebral blood flow due to reduced intracranial volume, potentially leading to cognitive deficits. In this study we test the hypothesis that intracranial volume and whole brain volume in infants with unilateral coronal synostosis differs from those in unaffected infants.


METHODS
Our study sample consists of magnetic resonance images acquired from 7- to 72-week-old infants with right unilateral coronal synostosis prior to surgery (n  =  10) and age-matched unaffected infants (n  =  10). We used Analyze 9.0 software to collect three cranial volume measurements. We used nonparametric tests to determine whether the three measures differ between the two groups. Correlations were calculated between age and the three volume measures in each group to determine whether the growth trajectory of the measurements differ between children with right unicoronal synostosis and unaffected infants.


RESULTS
Our results show that the three volume measurements are not reduced in infants with right unicoronal synostosis relative to unaffected children. Correlation analyses between age and various volume measures show similar correlations in infants with right unicoronal synostosis compared with unaffected children.


CONCLUSIONS
Our results show that the relationship between brain size and intracranial size in infants with right unicoronal synostosis is similar to that in unaffected children, suggesting that reduced intracranial volume is not responsible for alterations of the brain in craniosynostosis.
Hill
Cheryl A
CA
Vaddi
S
S
Moffitt
Amanda
A
Kane
A A
AA
Marsh
Jeffrey L
JL
Panchal
Jayesh
J
Richtsmeier
Joan T
JT
Aldridge
Kristina
K
D000367:Age Factors; D001921:Brain / Q000254:growth & development / Q000473:pathology*; D016022:Case-Control Studies; D003393:Cranial Sutures / Q000002:abnormalities; D003398:Craniosynostoses / Q000473:pathology* / Q000503:physiopathology; D005624:Frontal Bone / Q000002:abnormalities*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D009929:Organ Size; D010294:Parietal Bone / Q000002:abnormalities*
J Anat. 2005 Apr;206(4):373-85
15817105
Childs Nerv Syst. 2000 Nov;16(10-11):645-58
11151714
Plast Reconstr Surg. 1998 Sep;102(3):619-28; discussion 629-32
9727425
Neurosurgery. 1981 Oct;9(4):366-72
7301080
AJNR Am J Neuroradiol. 2003 Jan;24(1):45-51
12533326
J Neurosurg. 1982 Sep;57(3):370-7
7097333
Neurosurg Clin N Am. 1991 Jul;2(3):569-85
1821305
Childs Nerv Syst. 2007 Mar;23(3):269-81
17186250
Childs Nerv Syst. 1998 Jun;14(6):247-55
9694336
Childs Nerv Syst. 2005 Oct;21(10):861-70
15791470
Plast Reconstr Surg. 2007 May;119(6):1874-1881
17440368
Plast Reconstr Surg. 1987 Jan;79(1):24-32
3797514
Childs Nerv Syst. 2005 Oct;21(10):913-21
15871027
Br J Plast Surg. 1992 Jul;45(5):394-7
1638296
Front Oral Biol. 2008;12:79-90
18391496
Semin Pediatr Neurol. 2004 Dec;11(4):262-7
15828710
J Neurosurg. 2005 Aug;103(2 Suppl):137-41
16370279
Surg Neurol. 1984 Sep;22(3):249-52
6463834
Plast Reconstr Surg. 1992 Sep;90(3):377-81
1513883
J Anat. 2002 Jul;201(1):31-9
12171474
Cleft Palate Craniofac J. 1999 Jul;36(4):314-21
10426597
J Exp Zool B Mol Dev Evol. 2006 Jul 15;306(4):360-78
16526048
Anat Rec A Discov Mol Cell Evol Biol. 2005 Aug;285(2):690-8
15977220
Plast Reconstr Surg. 2004 Feb;113(2):557-65
14758218
Pediatr Neurosurg. 2002 Dec;37(6):310-20
12422046
J Neurosurg. 1999 Oct;91(4):617-25
10507384
J Craniofac Surg. 1998 May;9(3):234-9
9693554
J Pediatr Psychol. 2004 Dec;29(8):651-68
15491988
Cleft Palate Craniofac J. 1998 May;35(3):194-6
9603551
J Neurosurg. 2007 Aug;107(2 Suppl):103-10
18459881
J Craniofac Surg. 1990 Jan;1(1):1-3
2088558
Surg Neurol. 2007;68 Suppl 2:S18-21; discussion S21
18037036
Pediatr Neurosurg. 1995;22(5):235-40
7547454