[Adipocytokines in rheumatoid arthritis and obesity].
In obese rheumatoid arthritis (RA) patients inflammatory mechanisms and cardiovascular secondary disorders are possibly related to changed expression of adipocytokines. Various adipocytokines and inflammatory parameters were examined in 112 patients (23.2% men; 76.8% women) suffering from RA: leptin, adiponectin, visfatin, sCD40 L, CRP, and ESR. Average BMI was 27.6 (+/-5.6). Leptin and BMI as well as visfatin and BMI correlated positively, BMI and adiponectin, however, showed a negative correlation. Significant differences between normal-weight and obese RA patients were found in both leptin and adiponectin measurements. Visfatin showed a positive correlation with CRP; sCD40 ligand which is a marker for increased T-cell activity correlated with CRP and ESR. Patients with low adiponectin levels (<10 microg/ml) more often suffered from cardiovascular diseases (28.6%) than those with enhanced adiponectin (14.3%). Increased pro-inflammatory leptin and decreased anti-inflammatory adiponectin in obese RA patients can be associated with RA activity and enhanced cardiovascular risk.
Fagerer
Nicola
N
Ludwig Boltzmann Cluster für Rheumatologie, Balneologie und Rehabilitation, Ludwig Boltzmann Institut für Rehabilitation interner Erkrankungen, Saalfelden, Austria.
Kullich
Werner
W
D054392:Adipokines / Q000502:physiology*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D001799:Blood Sedimentation; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood; D002318:Cardiovascular Diseases / Q000503:physiopathology; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D009765:Obesity / Q000503:physiopathology*; D012016:Reference Values; D012307:Risk Factors; D013223:Statistics as Topic; D055815:Young Adult
C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D016207:Cytokines; D018836:Inflammation Mediators; D020738:Leptin; D023201:CD40 Ligand; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
Ann Rheum Dis. 2000 Mar;59(3):190-5
10700427
Ann Rheum Dis. 2009 Feb;68(2):242-5
18677010
Circulation. 2002 Oct 8;106(15):1904-5
12370209
J Immunol. 2007 Feb 1;178(3):1748-58
17237424
Clin Endocrinol (Oxf). 2007 Nov;67(5):796-800
17634078
J Immunol. 2005 Mar 15;174(6):3137-42
15749839
Rheumatol Int. 2007 Aug;27(10):947-54
17443329
Metabolism. 2007 Aug;56(8):1131-4
17618961
Curr Cardiol Rep. 2009 Nov;11(6):452-9
19863870
Scand J Rheumatol. 2007 Mar-Apr;36(2):101-6
17476615
Z Rheumatol. 2007 Mar;66(2):139-41
17333076
J Int Bioethique. 2004 Mar;15(1):124-9
15835069
J Biol Chem. 2001 Jul 6;276(27):25096-100
11342529
Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):961-7
11397704
Wien Med Wochenschr. 2002;152(9-10):220-2
12094392
J Rheumatol. 2002 Apr;29(4):772-82
11950021
Gend Med. 2009 Sep;6(3):463-70
19850242
Autoimmunity. 2004 Sep-Nov;37(6-7):457-64
15621572
Ann Rheum Dis. 2009 Aug;68(8):1271-6
18701555
Nutr Rev. 2002 Oct;60(10 Pt 2):S1-14; discussion S68-84, 85-7
12403078
Blood. 2000 Sep 1;96(5):1723-32
10961870
J Rheumatol. 2009 Sep;36(9):1885-91
19684150
Ann Rheum Dis. 2006 Sep;65(9):1198-201
16414972
J Pediatr (Rio J). 2007 Nov;83(5 Suppl):S192-203
17989837
Circulation. 2003 Feb 11;107(5):671-4
12578865
Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2031-41
15653761
J Physiol Pharmacol. 2006 Dec;57(4):505-28
17229978
J Biol Chem. 2003 Aug 29;278(35):32801-9
12810728
Circulation. 1999 Dec 21-28;100(25):2473-6
10604883
Transl Res. 2010 Feb;155(2):71-7
20129487
J Clin Endocrinol Metab. 2007 Dec;92(12):4783-91
17878256
Rheumatology (Oxford). 2006 Aug;45(8):944-50
16720637
J Clin Invest. 2001 Nov;108(10):1533-40
11714745
Ann Rheum Dis. 2003 Oct;62(10):952-6
12972473
J Rheumatol. 2001 Dec;28(12):2583-90
11764201
N Engl J Med. 1996 Feb 1;334(5):292-5
8532024
South Med J. 2006 Oct;99(10):1078-83
17100028