Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women.
OBJECTIVE
To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes.


METHODS
In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes.


RESULTS
After adjusting for matching factors and diabetes risk factors, including BMI, higher levels of plasma 25-OHD were associated with a lower risk for type 2 diabetes. The odds ratio for incident type 2 diabetes in the top (median 25-OHD, 33.4 ng/ml) versus the bottom (median 25-OHD, 14.4 ng/ml) quartile was 0.52 (95% CI 0.33-0.83). The associations were consistent across subgroups of baseline BMI, age, and calcium intake.


CONCLUSIONS
Plasma 25-OHD concentration was associated with lower risk of incident type 2 diabetes in women.
Pittas
Anastassios G
AG
Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts, USA. apittas@tuftsmedicalcenter.org
Sun
Qi
Q
Manson
Joann E
JE
Dawson-Hughes
Bess
B
Hu
Frank B
FB
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D014807:Vitamin D; C104450:25-hydroxyvitamin D
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