[Advanced achievements about neuroprotective mechanisms of paeoniflorin].
Paeoniflorin is one of the bioactive components of Paeonia lactiflora, a traditional Chinese herbal medicine. Some recent studies prove its distinguished neuroprotective effect. These neuroprotective mechanisms have become hot points and show closely correlated to activating adenosine A1 receptor, ameliorating the function of cholinergic nerve, regulating ion channel homeostasis, retarding oxidative stress and apoptosis of the neurocytes, promoting nerve growth, having an influence on astrocytes and being ableto penetrate though blood brain barrier. In this review, we present the neuroprotective mechanisms of paeoniflorin in the following eight aspects.
Zhu
Yefang
Y
Neonatology Department, Chongqing Children's Hospital, Chongqing Medical University, Chongqing 400014, China.
Dang
Shanshan
S
Hua
Ziyu
Z
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001565:Benzoates / Q000032:analysis / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000032:analysis / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology*; D005960:Glucosides / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D039821:Monoterpenes; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000032:analysis / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D029596:Paeonia / Q000737:chemistry; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; D018696:Neuroprotective Agents; C015423:peoniflorin; D006027:Glycosides