[Positive interaction between immunosuppressive and antifungal drugs].
Immunosuppressive and antifungal drugs are frequently associated to treat solid organ transplant patients or patients with hematological malignancies. To cure invasive fungal infection (IFI), immunosuppression has to be reduced. However, immunosuppressive drugs such as cyclosporin A, tacrolimus, sirolimus (rapamycin) or mycophenolate mofetil possess antifungal properties. Indeed fungi and humans have in common calcineurin and TOR signalization pathways which are inhibited by these molecules. In vitro experiences suggest a positive interaction between immunosuppressive and antifungal drugs such as amphotericin B, azole and echinocandins. These results are confirmed by clinical findings and thus offer further therapeutic possibilities in the context of solid organ transplantation. double dagger.
Rammaert
Blandine
B
Institut Pasteur du Cambodge, unité d'épidémiologie et de santé publique, BP 983, Phnom Penh, Royaume du Cambodge, Paris, France. brammaert@yahoo.fr
Lortholary
Olivier
O
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014181:Transplantation Immunology
D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D000666:Amphotericin B; D058570:TOR Serine-Threonine Kinases