O-silylative Passerini reaction: a new one-pot synthesis of α-siloxyamides.
A new method for the highly effective synthesis of α-siloxyamides is described. The addition of isocyanide to aldehyde proceeded smoothly in the presence of silanol to give the corresponding α-siloxyamides in high yields. A wide range of aldehydes and isocyanides are applicable in this reaction.
Soeta
Takahiro
T
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. soeta@se.kanazawa-u.ac.jp
Kojima
Yuuki
Y
Ukaji
Yutaka
Y
Inomata
Katsuhiko
K