title: Postoperative recurrence as an associated factor of malignant transformation of oral dysplastic leukoplakia.
abstract: OBJECTIVE
  To evaluate the clinically associated factors of malignant transformation in patients who received laser surgery for oral dysplastic leukoplakia.
  
  
  METHODS
  The clinicopathological data of patients receiving laser surgery for dysplastic leukoplakia from 2002 to 2008 and HPV genomic DNA extracted from paraffin-embedded specimens were analyzed statistically.
  
  
  RESULTS
  A total 114 patients, 90 males and 24 females with an average age of 49.7 ± 12.2 years were enrolled. The follow-up period ranged from 1.07 to 7.43 years (mean 3.4 ± 1.3 years). Thirteen cases had malignant transformation (11.4%). Multiple-focus lesions, non-homogeneous leukoplakia, high-grade dysplasia and recurrence after laser treatment were significant factors in univariate analysis. Multivariate analysis showed that recurrence (relative risk = 9.40) was the independent prognostic factor for malignant transformation.
  
  
  CONCLUSIONS
  Recurrence after laser treatment is an independent prognostic factor predicting malignant transformation of dysplastic oral leukoplakia.
authors.affiliation: Department of Otolaryngology, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China. sweeyang @ gmail.com
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Chang-Jer
authors.initials: CJ
authors.lastname: Wu
authors.forename: Yun-Shien
authors.initials: YS
authors.lastname: Lee
authors.forename: Tai-An
authors.initials: TA
authors.lastname: Chen
authors.forename: Chi-Neu
authors.initials: CN
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000706:statistics & numerical data; D054020:Lasers, Gas; D007972:Leukoplakia, Oral / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology*; D018307:Neoplasms, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors