title: Direct C-H arylation of electron-deficient heterocycles with arylboronic acids.
abstract: A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.
authors.affiliation: Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Seiple
authors.forename: Shun
authors.initials: S
authors.lastname: Su
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Rodriguez
authors.forename: Ryan
authors.initials: R
authors.lastname: Gianatassio
authors.forename: Yuta
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Adam L
authors.initials: AL
authors.lastname: Sobel
authors.forename: Phil S
authors.initials: PS
authors.lastname: Baran
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D006571:Heterocyclic Compounds; D002244:Carbon; D006859:Hydrogen
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