Ferroportin and erythroid cells: an update.
In recent years there have been major advances in our knowledge of the regulation of iron metabolism that have had implications for understanding the pathophysiology of some human disorders like beta-thalassemia and other iron overload diseases. However, little is known about the relationship among ineffective erythropoiesis, the role of iron-regulatory genes, and tissue iron distribution in beta-thalassemia. The principal aim of this paper is an update about the role of Ferroportin during human normal and pathological erythroid differentiation. Particular attention will be given to beta-thalassemia and other diseases with iron overload. Recent discoveries indicate that there is a potential for therapeutic intervention in beta-thalassemia by means of manipulating iron metabolism.
Cianetti
Luciano
L
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Gabbianelli
Marco
M
Sposi
Nadia Maria
NM
Blood. 2005 Aug 1;106(3):1092-7
15831700
Blood Cells Mol Dis. 2008 May-Jun;40(3):360-9
17977032
Science. 1990 Sep 28;249(4976):1561-4
2218497
Blood. 1989 Jul;74(1):49-55
2665842
Blood. 2006 Mar 15;107(6):2557-61
16293607
J Hepatol. 2003 Nov;39(5):710-5
14568251
Blood. 2006 Jan 15;107(2):435-43
16109777
Blood Rev. 2008 Jul;22(4):195-210
18430498
Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8955-60
15956209
Blood Cells Mol Dis. 2005 Jul-Aug;35(1):33-46
15935710
J Mol Biol. 2009 Feb 27;386(3):717-32
19150361
Gastroenterology. 2001 May;120(6):1412-9
11313311
Curr Opin Hematol. 2009 May;16(3):187-94
19318943
Blood. 2008 Dec 15;112(13):5241-4
18824595
Biochim Biophys Acta. 1991 Nov 11;1090(3):311-6
1954253
Nat Rev Genet. 2001 Apr;2(4):245-55
11283697
Nature. 1989 May 4;339(6219):27-30
2469962
Annu Rev Pathol. 2009;4:489-515
19400694
EMBO J. 2001 Jun 1;20(11):2835-43
11387216
Blood. 2009 Jul 2;114(1):181-6
19414861
Blood. 1993 Dec 15;82(12):3515-23
8260692
Blood. 1997 Jan 1;89(1):1-25
8978272
Nature. 1994 Jun 16;369(6481):568-71
8202159
Nat Rev Mol Cell Biol. 2008 Jan;9(1):72-81
17987043
Cancer Control. 2003 Jan-Feb;10(1):9-16
12598852
Nature. 2000 Feb 17;403(6771):776-81
10693807
Blood. 2009 Feb 12;113(7):1555-63
19047680
Gut. 2008 Mar;57(3):374-82
17965061
J Biol Chem. 2001 Mar 16;276(11):7806-10
11113131
Blood. 1991 Jun 1;77(11):2316-21
1710148
J Biol Chem. 2001 Mar 16;276(11):7811-9
11113132
Blood. 2007 Jun 1;109(11):5027-35
17299088
Hum Mol Genet. 2002 May 15;11(11):1351-62
12019217
Blood. 1990 Jan 1;75(1):1-12
2153029
Biochem J. 2008 Apr 1;411(1):123-31
18072938
J Biol Chem. 2000 Jun 30;275(26):19906-12
10747949
Blood. 2006 Dec 1;108(12):3730-5
16882706
Cell. 2000 Jan 7;100(1):157-68
10647940
Blood. 2007 Mar 1;109(5):2205-9
17077321
Pediatr Ann. 2008 May;37(5):322-8
18543543
Nat Genet. 2006 May;38(5):531-9
16604073
Trends Cell Biol. 2007 Feb;17(2):93-100
17194590
Blood. 2002 Jul 15;100(2):695-7
12091367
Exp Hematol. 2005 Mar;33(3):259-71
15730849
Cell Metab. 2009 May;9(5):461-73
19416716
Nucleic Acids Res. 2007;35(21):7074-86
17942419
Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11
16246168
Blood. 2007 Oct 15;110(8):2864-71
17620452
Science. 2008 Dec 19;322(5909):1804-5
19095933
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3800-5
19234114
Int J Hematol. 2009 Dec;90(5):545-552
19915946
J Biol Chem. 2004 Feb 13;279(7):5480-7
14660636
Nat Med. 2007 Sep;13(9):1096-101
17721544
Hepatology. 2004 Jan;39(1):21-9
14752817
J Immunol. 1995 Jul 1;155(1):427-35
7602116
Curr Opin Hematol. 2002 Mar;9(2):93-100
11844990
Annu Rev Nutr. 1995;15:353-77
8527225
Pharmacol Ther. 2006 Aug;111(2):327-45
16513178
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8160-2
11459944
Cell. 2008 Feb 22;132(4):631-44
18295580
Blood Cells Mol Dis. 2006 Jan-Feb;36(1):26-32
16380275
J Clin Invest. 2001 Aug;108(4):619-23
11518736
Blood. 2008 Nov 1;112(9):3878-88
18694996
N Engl J Med. 2004 Jun 3;350(23):2383-97
15175440
Curr Opin Genet Dev. 1996 Oct;6(5):597-602
8939717
N Engl J Med. 2005 Sep 15;353(11):1135-46
16162884
Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L932-9
12376346
Blood. 2008 Jan 1;111(1):421-9
17951528
Blood Cells Mol Dis. 2002 Nov-Dec;29(3):315-26
12547222
Physiol Res. 2006;55(6):667-74
16497104
Haematologica. 2010 Aug;95(8):1261-8
20179090
Blood. 1995 Sep 15;86(6):2123-9
7662960
Biochem J. 2000 Dec 1;352 Pt 2:241-50
11085915
Development. 2004 Apr;131(8):1859-68
15084469
J Clin Invest. 2002 Oct;110(7):1037-44
12370282
Curr Opin Hematol. 2008 May;15(3):155-61
18391778
Blood. 1995 Sep 1;86(5):1661-70
7544638
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10289-10293
16801541
Sci Am. 1991 Dec;265(6):86-93
1684448
FEBS Lett. 2000 Sep 1;480(2-3):147-50
11034317
Mol Cell Biol. 2006 Apr;26(7):2845-56
16537925
Gene. 1999 Sep 3;237(1):105-11
10524241
IUBMB Life. 2004 Apr;56(4):177-84
15230344
Blood. 2008 Jun 15;111(12):5727-33
18326822
World J Gastroenterol. 2009 Feb 7;15(5):538-51
19195055
Blood. 2008 Jul 15;112(2):219-30
18606887
IUBMB Life. 2009 Aug;61(8):800-30
19621348
Development. 2004 Oct;131(19):4871-81
15342464
Haematologica. 2009 Mar;94(3):395-408
19181781
Haematologica. 2006 Jun;91(6):809-12
16769583
Blood. 2005 May 15;105(10):4096-102
15692071
FASEB J. 2010 Jun;24(6):2093-103
20124431
Crit Rev Oncog. 1993;4(3):241-76
8485201
Blood. 1988 Jun;71(6):1759-63
3259443
Blood. 1991 Dec 1;78(11):2791-808
1720034
Hematol J. 2002;3(2):63-89
12032869
Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G403-14
11841990
Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11
14746809
Blood. 1991 Feb 1;77(3):419-34
1991159
Expert Rev Mol Med. 2007 Dec 05;9(33):1-13
18053288
Curr Opin Hematol. 2008 May;15(3):169-75
18391780
Gastroenterology. 2002 Sep;123(3):835-44
12198710
Science. 2004 Dec 17;306(5704):2090-3
15514116
J Biol Chem. 1998 May 8;273(19):11783-90
9565602
Mol Cell. 2000 Feb;5(2):299-309
10882071
Cell Metab. 2005 Dec;2(6):399-409
16330325
Br J Haematol. 2006 Oct;135(1):129-38
16939499
Cell Metab. 2005 Mar;1(3):155-7
16054057
Pflugers Arch. 2004 Feb;447(5):801-6
12836025
Biochem J. 2006 Jun 1;396(2):265-75
16457665
Haematologica. 2005 Dec;90(12):1595-606
16330432
Annu Rev Biochem. 1998;67:753-91
9759503
J Biol Chem. 2000 May 26;275(21):16023-9
10821856
J Nutr. 2002 Apr;132(4):693-6
11925462
Biochim Biophys Acta. 2006 Jul;1763(7):690-9
16790283
Exp Hematol. 2008 Sep;36(9):1057-72
18718415
Blood. 2007 Apr 1;109(7):2693-9
17110456
Blood. 2006 Apr 1;107(7):2702-4
16332970
J Biol Chem. 1999 Sep 10;274(37):26071-8
10473555
Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G156-63
16081760
Blood. 1994 May 15;83(10):2795-801
8180375