Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.
OBJECTIVE
Cell activation through toll-like receptors (TLRs) has robust bipolar effects on host immunity and the pathogenesis of asthma. The TLR2 subfamily is a pivotal member of the TLR family. We sought to determine whether mutations in TLR2 subfamily genes affect the risk of asthma.


METHODS
A total of 318 asthmatic patients and 352 nonasthmatic controls were recruited. Eight single-nucleotide polymorphisms in TLR2 subfamily genes were detected using GenomeLab SNPstream (Beckman Coulter, Fullerton, California, USA).


RESULTS
We found that patients with the TLR2/rs7656411 TT variant homozygote had a significantly reduced risk of asthma when compared with those with the GG wild-type homozygote (adjusted odds ratio [OR], 0.63; 95% confidence interval (CI], 0.41-0.98; P = .036). Furthermore, a positive association was observed between the T allele of rs2381289 in TLR6 and allergic rhinitis in asthma (OR, 1.79; 95% CI, 1.10-2.91; P = .025), while the A allele of rs11466651 in TLRIO was negatively associated with allergic rhinitis (OR, 0.49; 95% CI, 0.26-0.95; P = .046).


CONCLUSIONS
Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma.
Qian
F H
FH
Department of Respiratory Medicine, First Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu, China.
Zhang
Q
Q
Zhou
L F
LF
Jin
G F
GF
Bai
J L
JL
Yin
K S
KS
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications / Q000235:genetics* / Q000503:physiopathology*; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D051201:Toll-Like Receptor 10 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D051216:Toll-Like Receptor 6 / Q000235:genetics / Q000276:immunology / Q000378:metabolism
C475955:TLR10 protein, human; C495368:TLR6 protein, human; D051201:Toll-Like Receptor 10; D051195:Toll-Like Receptor 2; D051216:Toll-Like Receptor 6