title: Dynamic cerebral autoregulation in stroke patients with a central sympathetic deficit.
abstract: OBJECTIVE
  To investigate the functional role of the sympathetic innervation on cerebral autoregulation.
  
  
  METHODS
  Seventeen patients with infarction of the dorsolateral medulla oblongata affecting central sympathetic pathways (Wallenberg's syndrome) and 21 healthy controls were included in the study. Cerebral blood flow velocity (CBFV) in the medial cerebral artery was investigated using transcranial Doppler ultrasound during decrease in cerebral perfusion pressure induced by leg-cuff test and tilt table.
  
  
  RESULTS
  Upon leg-cuff test, changes of cerebral blood flow and mean arterial blood pressure as well as autoregulatory index did not differ between patients or controls. No differences were found in changes of CBFV, mean arterial blood pressure and heart rate between patients or controls during the tilt table test.
  
  
  CONCLUSIONS
  We suggest that the sympathetic nervous system does not have an influence on cerebral autoregulation after decrease in perfusion pressure under normotonous conditions.
authors.affiliation: Department of Neurology, Division ofNeurological Pain Research and Therapy, University Hospital Schleswig-Holstein, Campus Kiel, Germany. j.gierthmuehlen@neurologie.uni-kiel.de
authors.forename: J
authors.initials: J
authors.lastname: Gierthmühlen
authors.forename: A
authors.initials: A
authors.lastname: Allardt
authors.forename: M
authors.initials: M
authors.lastname: Sawade
authors.forename: R
authors.initials: R
authors.lastname: Baron
authors.forename: G
authors.initials: G
authors.lastname: Wasner
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018667:Tilt-Table Test; D014463:Ultrasonography