Synthesis and antioxidant activity of new pyridines containing gallate moieties.
Pyridines containing the galloyl moiety have been prepared utilizing 4-acetyl pyrogallol. In addition, fused pyridines were synthesized from the obtained pyridines via further chemical transformations. The results indicated that compound 4a showed stronger DPPH scavenging activity than the other compounds, and the scavenging effect decreased in the following order 4a > t-BHQ > 2a > 2b > 3a > 3b > 4b. Accordingly, other antioxidant assays were conducted for 4a. The results suggested that compound 4a could be a good antioxidant candidate. The absence of mortality of rats receiving 5000 mg/kg body weight of 4a as single oral dose may indicate that it could be a safe antioxidant and may be used for further studies.
El-Ebiary
Nora M A
NM
National Research Centre, Dokki, Cairo, Egypt.
Swellem
Randa H
RH
Mossa
Abdel-Tawab H
AT
Nawwar
Galal A M
GA
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D011748:Pyrogallol / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
D000975:Antioxidants; D016166:Free Radical Scavengers; D011725:Pyridines; D011748:Pyrogallol