An efficient procedure based on a MW-assisted Horner-Wadsworth-Emmons reaction for the synthesis of (Z)-3,3-trisubstituted-alpha,beta-unsaturated esters.
A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-alpha,beta-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.
Rossi
Daniela
D
Dipartimento di Chimica Farmaceutica, viale Taramelli 12, Pavia 27100, Italy.
Baraglia
Anna Carnevale
AC
Serra
Massimo
M
Azzolina
Ornella
O
Collina
Simona
S
D000475:Alkenes / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis; D004952:Esters / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism
D000475:Alkenes; D001688:Biological Products; D004952:Esters; D007659:Ketones
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