Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children.
Development of natural antibodies to 3 nontypeable Haemophilus influenzae (NTHi) outer membrane proteins (D, P6 and OMP26) was prospectively studied in 130 children 6-30 months of age during NP colonization and acute otitis media (AOM). IgG antibody to protein D, P6 and OMP26 increased with age (p<0.001). Serum IgG responses to NP colonization were different for the 3 proteins: protein D responses occurred at a later age than P6, and OMP26 responses were minimal. For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal.
Pichichero
Michael E
ME
Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA. michael.pichichero@rochestergeneral.org
Kaur
Ravinder
R
Casey
Janet R
JR
Sabirov
Albert
A
Khan
M Nadeem
MN
Almudevar
Anthony
A
D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D002675:Child, Preschool; D006192:Haemophilus Infections / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000276:immunology*; D006193:Haemophilus influenzae / Q000145:classification / Q000276:immunology; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008074:Lipoproteins / Q000276:immunology; D058885:Multilocus Sequence Typing; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000276:immunology / Q000382:microbiology*; D011446:Prospective Studies
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D018073:Haemophilus Vaccines; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D008074:Lipoproteins; C118414:OMP26 protein, Haemophilus influenzae; C069990:P6 outer membrane protein, Haemophilus; C067989:glpQ protein, Haemophilus influenzae
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