title: Chronic kidney disease and mortality in implantable cardioverter-defibrillator recipients.
abstract: Incidence of sudden cardiac death (SCD) in end-stage renal disease (ESRD) remains high. Limited data is available about whether implantable cardioverter-defibrillators (ICDs) can prevent arrhythmic death in patients with chronic kidney disease (CKD). The purpose of this retrospective study was to determine the impact of CKD on all-cause and sudden cardiac death in ICD recipients. We evaluated 441 consecutive patients who underwent ICD implantation at our center between 1994 and 2002. We found that mortality rate was higher in patients with eGFR <60 mL/min and those with ESRD on hemodialysis (43%, n = 69/162 and 54%, n = 12/22, resp.) than in patients with eGFR >/=60 mL/min (23%, n = 58/257; P < .0005). The SCD rate was also higher in the patients with ESRD (50%) than in CKD patients not on dialysis (10.2%; P < .0005). Mortality rate for single-chamber ICDs was 56.8% in comparison with dual-chamber ICDs (38.1%) and for biventricular ICDs (5.0%) (P < .0005).
authors.affiliation: Division of Cardiology, Department of Medicine, St. John Hospital & Medical Center, 22101 Moross Road, Cardiac Cath Lab, Detroit, MI- 48236, USA.
authors.forename: Aamir
authors.initials: A
authors.lastname: Cheema
authors.forename: Tejwant
authors.initials: T
authors.lastname: Singh
authors.forename: Manreet
authors.initials: M
authors.lastname: Kanwar
authors.forename: Karuna
authors.initials: K
authors.lastname: Chilukuri
authors.forename: Viqar
authors.initials: V
authors.lastname: Maria
authors.forename: Fareena
authors.initials: F
authors.lastname: Saleem
authors.forename: Katrina
authors.initials: K
authors.lastname: Johnson
authors.forename: John
authors.initials: J
authors.lastname: Frank
authors.forename: Luis
authors.initials: L
authors.lastname: Pires
authors.forename: Sohail
authors.initials: S
authors.lastname: Hassan
references.citation: Am J Kidney Dis. 2003 Jan;41(1):1-12
references.pmid: 12500213
references.citation: N Engl J Med. 1996 Dec 26;335(26):1933-40
references.pmid: 8960472
references.citation: Ann Intern Med. 2004 Sep 7;141(5):381-90
references.pmid: 15353430
references.citation: Circulation. 2009 Feb 10;119(5):663-70
references.pmid: 19171855
references.citation: J Am Coll Cardiol. 1998 Dec;32(7):1900-8
references.pmid: 9857870
references.citation: N Engl J Med. 2002 Mar 21;346(12):877-83
references.pmid: 11907286
references.citation: N Engl J Med. 1992 Dec 31;327(27):1912-8
references.pmid: 1454086
references.citation: Mayo Clin Proc. 2005 Oct;80(10):1270-7
references.pmid: 16212138
references.citation: Am Heart J. 1993 May;125(5 Pt 1):1306-10
references.pmid: 8480582
references.citation: J Am Soc Nephrol. 2004 Mar;15(3):538-48
references.pmid: 14978155
references.citation: N Engl J Med. 1997 Nov 27;337(22):1576-83
references.pmid: 9411221
references.citation: J Am Soc Nephrol. 2004 May;15(5):1307-15
references.pmid: 15100371
references.citation: N Engl J Med. 2004 Dec 9;351(24):2481-8
references.pmid: 15590950
references.citation: Circulation. 2003 Oct 28;108(17):2154-69
references.pmid: 14581387
references.citation: Circulation. 1992 Oct;86(4):1206-16
references.pmid: 1394927
references.citation: J Interv Card Electrophysiol. 2004 Dec;11(3):199-204
references.pmid: 15548886
references.citation: Kidney Int. 1999 Apr;55(4):1553-9
references.pmid: 10201022
references.citation: N Engl J Med. 1999 Dec 16;341(25):1882-90
references.pmid: 10601507
references.citation: Circulation. 2002 Oct 15;106(16):2145-61
references.pmid: 12379588
references.citation: J Am Coll Cardiol. 2006 Jan 17;47(2):282-8
references.pmid: 16412848
references.citation: N Engl J Med. 2005 Jan 20;352(3):225-37
references.pmid: 15659722
references.citation: Eur Heart J. 2006 Jan;27(1):65-75
references.pmid: 16219658
references.citation: Kidney Int. 2005 Aug;68(2):818-25
references.pmid: 16014061
references.citation: J Am Coll Cardiol. 2003 May 7;41(9):1573-82
references.pmid: 12742300
references.citation: N Engl J Med. 2004 May 20;350(21):2140-50
references.pmid: 15152059