KIRs and their HLA ligands in remitting-relapsing multiple sclerosis.
Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (p(y)=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (p(y)=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.
Fusco
Caterina
C
Immunohematology and Transfusion Service, AORN A. Cardarelli, Naples, Italy. hla.cardarelli@libero.it
Guerini
Franca Rosa
FR
Nocera
Giustina
G
Ventrella
Gianluca
G
Caputo
Domenico
D
Valentino
Maria Antonietta
MA
Agliardi
Cristina
C
Gallotti
Jacopo
J
Morra
Vincenzo Brescia
VB
Florio
Ciro
C
Clerici
Mario
M
Lombardi
Maria Luisa
ML
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D016017:Odds Ratio; D054340:Receptors, KIR / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
D006680:HLA Antigens; C496212:KIR2DS1 protein, human; D008024:Ligands; D054340:Receptors, KIR