title: Efficacy and tolerability of one-site versus two-site phaco-trabeculectomy: a meta-analysis of randomized controlled clinical trials.
abstract: BACKGROUND
  Phacotrabeculectomy can be performed using one-site or two-site incisions. This meta-analysis evaluated the efficacy and tolerability of one-site versus two-site phacotrabeculectomy in the treatment of patients with coexisting cataract and glaucoma.
  
  
  METHODS
  A comprehensive literature search was performed according to the Cochrane Collaboration methodology to identify randomized controlled clinical trials comparing one-site with two-site phacotrabeculectomy. Studies meeting our predefined criteria were included in the meta-analysis. Efficacy estimates were measured by weighted mean difference (WMD) for the percentage intraocular pressure (IOP) reduction from baseline to end point, relative risk (RR) for the proportion of patients with a best-corrected visual acuity (BCVA) of 0.5 or better after surgery and complete success rates. Tolerability estimates were measured by RR for adverse events. All of outcomes were reported with 95% confidence interval (95%CI). Data were synthesised by Stata 10.1 for Windows.
  
  
  RESULTS
  Two-site phacotrabeculectomy was associated with greater reductions in IOP than the one-site procedure (WMD: -5.99, 95%CI: -10.74 - -1.24, P = 0.01). A greater proportion of patients also achieved a BCVA of 0.5 or better (RR: 0.91, 95%CI: 0.74 - 1.12, P = 0.36) and the target IOP without anti-glaucoma medication at the study end point (RR: 0.94, 95%CI: 0.83 - 1.07, P = 0.34) after two-site than one-site phacotrabeculectomy, but the differences were not significant. There were no significant differences in adverse events between two surgical procedures.
  
  
  CONCLUSIONS
  Two-site phacotrabeculectomy is superior to one-site phacotrabeculectomy in reducing IOP, but other post-operative effects are similar. One-site and two-site phacotrabeculectomies have similar adverse event rates.
authors.affiliation: Department of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China.
authors.forename: He-nan
authors.initials: HN
authors.lastname: Liu
authors.forename: Xiao-long
authors.initials: XL
authors.lastname: Chen
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Qing-zhu
authors.initials: QZ
authors.lastname: Nie
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D006801:Humans; D014130:Trabeculectomy / Q000009:adverse effects* / Q000379:methods*