title: The normal microenvironment directs mammary gland development.
abstract: Normal development of the mammary gland is a multidimensional process that is controlled in part by its mammary microenvironment. The mammary microenvironment is a defined location that encompasses mammary somatic stem cells, neighboring signaling cells, the basement membrane and extracellular matrix, mammary fibroblasts as well as the intercellular signals produced and received by these cells. These dynamic signals take numerous forms including growth factors, steroids, cell-cell or cell-basement membrane physical interactions. Cellular growth and differentiation of the mammary gland throughout the developmental stages are regulated by changes in these signals and interactions. The purpose of this review is to summarize current information and research regarding the role of the mammary microenvironment during normal glandular development.
authors.affiliation: Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
authors.forename: Erin J
authors.initials: EJ
authors.lastname: McCave
authors.forename: Cheryl A P
authors.initials: CA
authors.lastname: Cass
authors.forename: Karen J L
authors.initials: KJ
authors.lastname: Burg
authors.forename: Brian W
authors.initials: BW
authors.lastname: Booth
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000254:growth & development* / Q000378:metabolism; D042361:Mammary Glands, Human / Q000254:growth & development* / Q000378:metabolism
references.citation: Genes Dev. 1995 Aug 1;9(15):1896-908
references.pmid: 7544313
references.citation: J Theor Biol. 1982 Nov 7;99(1):31-68
references.pmid: 6892044
references.citation: Dev Biol. 2008 Sep 1;321(1):77-87
references.pmid: 18585375
references.citation: Breast Cancer Res. 2003;5(3):130-5
references.pmid: 12793893
references.citation: J Natl Cancer Inst. 2006 Jul 19;98(14):1011-4
references.pmid: 16849684
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5455-60
references.pmid: 17369357
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9744-9
references.pmid: 12897242
references.citation: Tissue Eng. 2005 Mar-Apr;11(3-4):556-66
references.pmid: 15869434
references.citation: Annu Rev Pathol. 2008;3:313-39
references.pmid: 18039125
references.citation: J Mammary Gland Biol Neoplasia. 2004 Oct;9(4):361-74
references.pmid: 15838605
references.citation: Mech Ageing Dev. 2002 Sep;123(11):1505-19
references.pmid: 12425957
references.citation: Exp Cell Res. 2000 Oct 10;260(1):146-59
references.pmid: 11010819
references.citation: Biomaterials. 2010 May;31(13):3622-30
references.pmid: 20149444
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2196-201
references.pmid: 16452162
references.citation: Philos Trans A Math Phys Eng Sci. 2010 Apr 28;368(1917):1839-62
references.pmid: 20308106
references.citation: Genes Dev. 2000 Mar 15;14(6):650-4
references.pmid: 10733525
references.citation: Semin Cell Dev Biol. 2010 Feb;21(1):11-8
references.pmid: 19857593
references.citation: Mol Reprod Dev. 1995 Jul;41(3):277-86
references.pmid: 8588926
references.citation: Dev Cell. 2002 Dec;3(6):877-87
references.pmid: 12479812
references.citation: Annu Rev Cell Dev Biol. 2003;19:173-206
references.pmid: 14570568
references.citation: Endocr Relat Cancer. 2005 Sep;12(3):483-95
references.pmid: 16172188
references.citation: Mol Pharm. 2008 Sep-Oct;5(5):849-62
references.pmid: 18680382
references.citation: Oncogene. 2011 Feb 10;30(6):679-89
references.pmid: 20890308
references.citation: Dev Biol. 2007 Mar 1;303(1):29-44
references.pmid: 17222404
references.citation: EMBO J. 1993 May;12(5):1835-45
references.pmid: 8491177
references.citation: Breast J. 2001 Sep-Oct;7(5):278-91
references.pmid: 11906437
references.citation: Nature. 2006 Dec 7;444(7120):761-5
references.pmid: 17151667
references.citation: EMBO J. 2005 Jun 1;24(11):1942-53
references.pmid: 15889143
references.citation: Stem Cell Rev. 2007 Jun;3(2):147-56
references.pmid: 17873347
references.citation: Cell Cycle. 2009 Apr 15;8(8):1127-32
references.pmid: 19282662
references.citation: Development. 1992 May;115(1):49-58
references.pmid: 1638991
references.citation: Nature. 2010 Jun 10;465(7299):798-802
references.pmid: 20383121
references.citation: Biomaterials. 2005 Oct;26(29):5855-63
references.pmid: 15949551
references.citation: J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):71-82
references.pmid: 17318269
references.citation: Breast Cancer Res. 2002;4(4):155-64
references.pmid: 12100741
references.citation: J Cell Sci. 2009 Jan 15;122(Pt 2):207-14
references.pmid: 19118213
references.citation: J Cell Sci. 2003 Jun 15;116(Pt 12):2377-88
references.pmid: 12766184
references.citation: Annu Rev Cell Dev Biol. 2005;21:605-31
references.pmid: 16212509
references.citation: Adv Exp Med Biol. 2001;501:61-70
references.pmid: 11787732
references.citation: Int J Biochem Cell Biol. 2007;39(11):1987-94
references.pmid: 17719831
references.citation: J Mammary Gland Biol Neoplasia. 1999 Jan;4(1):9-19
references.pmid: 10219903
references.citation: Mol Carcinog. 2004 Dec;41(4):207-20
references.pmid: 15468292
references.citation: Breast Cancer Res. 2004;6(1):1-11
references.pmid: 14680479
references.citation: Cell Growth Differ. 1998 Jun;9(6):451-64
references.pmid: 9663464
references.citation: Methods. 2003 Jul;30(3):247-55
references.pmid: 12798139
references.citation: Nature. 2006 Feb 23;439(7079):993-7
references.pmid: 16395311
references.citation: J Mammary Gland Biol Neoplasia. 2003 Oct;8(4):383-94
references.pmid: 14985635
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14891-6
references.pmid: 18809919
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3871-6
references.pmid: 17360445
references.citation: Curr Opin Cell Biol. 1990 Oct;2(5):864-74
references.pmid: 2083086
references.citation: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5076-81
references.pmid: 9560231
references.citation: Cancer Res. 1978 Nov;38(11 Pt 2):4066-70
references.pmid: 698955
references.citation: J Mammary Gland Biol Neoplasia. 1998 Apr;3(2):133-50
references.pmid: 10819523
references.citation: Clin Exp Metastasis. 2009;26(1):35-49
references.pmid: 18814043
references.citation: Biomaterials. 2007 Jan;28(3):450-8
references.pmid: 16997371
references.citation: J Cell Biol. 1997 Apr 7;137(1):231-45
references.pmid: 9105051
references.citation: Growth Factors. 2007 Aug;25(4):227-35
references.pmid: 18092231
references.citation: Nat Cell Biol. 2008 Jun;10(6):716-22
references.pmid: 18469806
references.citation: J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):229-38
references.pmid: 17115264
references.citation: J Mammary Gland Biol Neoplasia. 2000 Apr;5(2):165-85
references.pmid: 11149571
references.citation: Endocr Relat Cancer. 2005 Dec;12(4):749-60
references.pmid: 16322320
references.citation: Tissue Eng Part C Methods. 2008 Sep;14(3):261-71
references.pmid: 18694322
references.citation: In Vitro Cell Dev Biol Anim. 2010 Sep;46(8):673-84
references.pmid: 20585895
references.citation: Tissue Eng. 1999 Apr;5(2):139-51
references.pmid: 10358221
references.citation: Development. 2000 Jun;127(11):2269-82
references.pmid: 10804170
references.citation: Cancer Treat Res. 1996;83:3-22
references.pmid: 8826639
references.citation: Breast Dis. 2003;18:61-73
references.pmid: 15687689
references.citation: Nat Methods. 2007 Apr;4(4):359-65
references.pmid: 17396127
references.citation: BMC Cell Biol. 2008 Aug 18;9:46
references.pmid: 18710550
references.citation: FASEB J. 1993 Jun;7(9):737-43
references.pmid: 8330681
references.citation: Cancer Res. 1959 Jun;19(5):515-20
references.pmid: 13663040
references.citation: Development. 1996 Jan;122(1):181-93
references.pmid: 8565829
references.citation: Development. 2002 Mar;129(6):1377-86
references.pmid: 11880347
references.citation: Cancer Cell. 2005 Sep;8(3):241-54
references.pmid: 16169468
references.citation: J Mammary Gland Biol Neoplasia. 2004 Oct;9(4):325-42
references.pmid: 15838603
references.citation: Endocrinology. 2001 Jul;142(7):3214-22
references.pmid: 11416044
references.citation: Cell Growth Differ. 1998 Sep;9(9):777-85
references.pmid: 9751121
references.citation: Biomaterials. 2003 Aug;24(18):3125-32
references.pmid: 12895585
references.citation: Nature. 2006 Jan 5;439(7072):84-8
references.pmid: 16397499
references.citation: Biomaterials. 2006 Dec;27(36):6052-63
references.pmid: 16973213
references.citation: J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):231-47
references.pmid: 16807803
references.citation: Genes Dev. 1993 Dec;7(12A):2308-17
references.pmid: 8253379
references.citation: Development. 1999 Jan;126(2):335-44
references.pmid: 9847247
references.citation: J Mammary Gland Biol Neoplasia. 2004 Jan;9(1):15-26
references.pmid: 15082915
references.citation: Exp Cell Res. 2010 Feb 1;316(3):422-32
references.pmid: 19913532
references.citation: J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):279-90
references.pmid: 20717712
references.citation: Dev Biol. 1995 Mar;168(1):47-61
references.pmid: 7883078
references.citation: Breast Cancer Res. 2009;11(4):R62
references.pmid: 19706193
references.citation: Nat Cell Biol. 2007 Feb;9(2):201-9
references.pmid: 17187062
references.citation: Eur J Cancer. 2008 Dec;44(18):2760-5
references.pmid: 19026532
references.citation: Cancer Res. 2010 Aug 1;70(15):6336-43
references.pmid: 20647316
references.citation: Endocrinology. 2002 Sep;143(9):3427-34
references.pmid: 12193555
references.citation: J Cell Biol. 2005 Nov 21;171(4):717-28
references.pmid: 16301336
references.citation: Breast Cancer Res. 2008;10(1):203
references.pmid: 18304381
references.citation: Histochem Cell Biol. 2008 Dec;130(6):1105-18
references.pmid: 19009245
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14821-6
references.pmid: 9843973
references.citation: Breast Cancer Res Treat. 1996;39(1):21-31
references.pmid: 8738603
references.citation: Mol Endocrinol. 2002 Sep;16(9):2034-51
references.pmid: 12198241