title: [Secreted proteins of Staphylococcus aureus].
abstract: Modern views on secreted proteins of Staphylococcus aureus are analyzed in the review. Spread of this pathogen is partially explained by wide spectrum of proteins secreted by this microorganism. Four groups of proteins secreted by staphylococci could be assigned. These are peptidoglycanhydrolases, intracellular enzymes (proreases, lipases etc.), membrane toxins (hemolyzins and leukocidins), and superantigens. Role of some proteins, especially belonging to latter groups, for the staphylococcal virulence and pathogenesis of staphylococcal infectious is known at this time. Genome sequencing of several strains of S. aureus also allowed to predict main characteristics of many secreted proteins such as molecular mass and spatial structure. Further studies of these proteins could be useful for development of staphylococcal vaccines and other immunity-modifying drugs.
authors.forename: R G
authors.initials: RG
authors.lastname: Priatkin
authors.forename: O M
authors.initials: OM
authors.lastname: Kuz'menko
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D006460:Hemolysin Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007956:Leukocidins / Q000378:metabolism / Q000502:physiology; D008049:Lipase / Q000378:metabolism / Q000502:physiology; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000378:metabolism / Q000502:physiology; D010447:Peptide Hydrolases / Q000378:metabolism / Q000502:physiology; D021381:Protein Transport; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000472:pathogenicity; D018089:Superantigens / Q000378:metabolism / Q000502:physiology; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D006460:Hemolysin Proteins; D007956:Leukocidins; D018089:Superantigens; D008049:Lipase; D010447:Peptide Hydrolases; D009238:N-Acetylmuramoyl-L-alanine Amidase