Prevalence of hematological abnormalities in patients with Sheehan's syndrome: response to replacement of glucocorticoids and thyroxine.
Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients with Sheehan's syndrome. Forty patients of Sheehan's syndrome and an equal number of age and parity matched healthy controls were studied for prevalence of hematological abnormalities. Hemoglobin concentration, hematocrit, red cell, white cell and platelet count were significantly decreased in patients with Sheehan's syndrome compared to controls. Frequency of anemia, leucopenia, thrombocytopenia and pancytopenia was significantly higher in these patients compared to controls. After achieving euthyroid and eucortisol state, there was a complete recovery of these hematological abnormalities. We conclude that anemia and other cytopenias are common in patients with Sheehan's syndrome and replacement with thyroxine and glucocorticoids results in complete recovery of these abnormalities.
Laway
Bashir Ahmad
BA
Department of Endocrinology, Sher-I- Kashmir Institute of Medical Sciences Soura, Srinagar, Jammu and Kashmir, India.
Mir
Shahnaz Ahmad
SA
Bashir
Mir Iftikhar
MI
Bhat
Javid Rasool
JR
Samoon
Jeelani
J
Zargar
Abdul Hamid
AH
D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000188:drug therapy* / Q000196:embryology*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000196:embryology*; D008297:Male; D010198:Pancytopenia / Q000188:drug therapy / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D013974:Thyroxine / Q000627:therapeutic use*
D005938:Glucocorticoids; D013974:Thyroxine
Br J Haematol. 1976 Aug;33(4):575-82
827305
J Endocrinol Invest. 2005 Jun;28(6):528-33
16117194
Pituitary. 2003;6(4):181-8
15237929
J Clin Endocrinol Metab. 2002 Sep;87(9):4137-41
12213861
Ann Hematol. 2009 May;88(5):405-10
18797868
Am J Hematol. 1994 Nov;47(3):249-50
7942799
J Immunol. 1996 Dec 15;157(12):5748-54
8955229
Endocr J. 1995 Dec;42(6):803-9
8822323
Fertil Steril. 2005 Aug;84(2):523-8
16084902
J Clin Invest. 1976 Jan;57(1):57-62
173742
Br J Haematol. 1977 Oct;37(2):173-7
603753
Clin Endocrinol (Oxf). 2001 Dec;55(6):749-54
11895216
Endocrinology. 1950 Nov;47(5):364-9
14793501
Blood. 1978 Jun;51(6):1117-24
647115
Ann Hematol. 2010 Mar;89(3):305-8
19697029
Platelets. 2010;21(4):303-6
20201635
EMBO J. 1997 Dec 1;16(23):6926-35
9384572
Ann Saudi Med. 1996 May;16(3):338-41
17372485
Br J Haematol. 1989 Apr;71(4):457-62
2469458
Blood. 1972 Feb;39(2):229-48
5009028