title: Autoinflammatory syndromes: diagnosis and management.
abstract: During the last decades the description of autoinflammatory syndromes induced great interest among the scientific community. Mainly rheumatologists, immunologists and pediatricians are involved in the discovery of etiopathogenesis of these syndromes and in the recognition of affected patients. In this paper we will discuss the most important clues of monogenic and non-genetic inflammatory syndromes to help pediatricians in the diagnosis and treatment of these diseases.
authors.affiliation: Department of Pediatrics, University of Chieti, Via Vestini 5, 66100 Chieti, Italy. s.desanctis@yahoo.it
authors.forename: Sara
authors.initials: S
authors.lastname: De Sanctis
authors.forename: Manuela
authors.initials: M
authors.lastname: Nozzi
authors.forename: Marianna
authors.initials: M
authors.lastname: Del Torto
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scardapane
authors.forename: Stefania
authors.initials: S
authors.lastname: Gaspari
authors.forename: Giuseppina
authors.initials: G
authors.lastname: de Michele
authors.forename: Luciana
authors.initials: L
authors.lastname: Breda
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli
mesh_terms: D015551:Autoimmunity / Q000276:immunology*; D002648:Child; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use*; D056660:Hereditary Autoinflammatory Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011379:Prognosis; D013577:Syndrome; D014068:Tonsillectomy / Q000379:methods*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents
references.citation: Arthritis Rheum. 2008 Jun;58(6):1823-32
references.pmid: 18512793
references.citation: Clin Exp Rheumatol. 2004 Nov-Dec;22(6):791-2
references.pmid: 15638064
references.citation: Joint Bone Spine. 2007 Dec;74(6):544-50
references.pmid: 17950649
references.citation: Neth J Med. 2005 Jul-Aug;63(7):260-4
references.pmid: 16093577
references.citation: Arch Otolaryngol Head Neck Surg. 2008 Feb;134(2):136-40
references.pmid: 18283154
references.citation: Clin Pharmacol Ther. 2004 May;75(5):476-83
references.pmid: 15116060
references.citation: Eur J Pediatr. 2005 Jan;164(1):13-6
references.pmid: 15549379
references.citation: Nat Med. 2000 Dec;6(12):1399-402
references.pmid: 11100127
references.citation: Reumatismo. 2004 Jul-Sep;56(3):147-55
references.pmid: 15470520
references.citation: Medicine (Baltimore). 2002 Sep;81(5):349-68
references.pmid: 12352631
references.citation: J Oral Pathol Med. 2008 Jul;37(6):319-23
references.pmid: 18221323
references.citation: Arthritis Rheum. 2008 Aug;58(8):2443-52
references.pmid: 18668535
references.citation: Arthritis Rheum. 2008 May;58(5):1516-20
references.pmid: 18438813
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R86-98
references.pmid: 16931648
references.citation: Trends Immunol. 2004 Sep;25(9):457-60
references.pmid: 15324736
references.citation: Nat Genet. 1999 Jun;22(2):175-7
references.pmid: 10369261
references.citation: Oral Dis. 2008 Nov;14(8):690-9
references.pmid: 19193198
references.citation: Rheumatology (Oxford). 2006 Sep;45(9):1140-3
references.pmid: 16527883
references.citation: N Engl J Med. 2006 Aug 10;355(6):581-92
references.pmid: 16899778
references.citation: Medicine (Baltimore). 2005 Jan;84(1):1-11
references.pmid: 15643295
references.citation: Arthritis Rheum. 2006 Mar;54(3):998-1008
references.pmid: 16508982
references.citation: Rheumatology (Oxford). 2003 Feb;42(2):235-9
references.pmid: 12595616
references.citation: Curr Opin Rheumatol. 2005 Sep;17(5):586-99
references.pmid: 16093838
references.citation: Trends Mol Med. 2007 Sep;13(9):381-8
references.pmid: 17822957
references.citation: Ann Intern Med. 2001 Sep 4;135(5):338-43
references.pmid: 11529697
references.citation: Allergy. 2007 Dec;62(12):1349-58
references.pmid: 17983370
references.citation: Ann N Y Acad Sci. 2007 Sep;1110:201-8
references.pmid: 17911435
references.citation: Arch Dis Child. 2002 Jun;86(6):434-5
references.pmid: 12023179
references.citation: Pediatr Rheumatol Online J. 2009 Jan 12;7:2
references.pmid: 19138427
references.citation: Rheumatol Int. 2006 Apr;26(6):489-96
references.pmid: 16283319
references.citation: J Allergy Clin Immunol. 2009 Dec;124(6):1141-9; quiz 1150-1
references.pmid: 20004775
references.citation: J Clin Immunol. 2008 May;28 Suppl 1:S73-83
references.pmid: 18368292
references.citation: Pediatr Nephrol. 2003 Sep;18(9):853-9
references.pmid: 12836090
references.citation: Arthritis Rheum. 2003 Sep;48(9):2632-44
references.pmid: 13130484
references.citation: N Engl J Med. 2009 Jun 4;360(23):2416-25
references.pmid: 19494217
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jul;102(1):35-9
references.pmid: 16831670
references.citation: J Microbiol Immunol Infect. 2005 Dec;38(6):444-6
references.pmid: 16341346
references.citation: Br J Haematol. 2009 Feb;144(3):279-302
references.pmid: 19120372
references.citation: Pediatrics. 1993 May;91(5):915-21
references.pmid: 8386351
references.citation: Medicine (Baltimore). 1994 May;73(3):133-44
references.pmid: 8190036
references.citation: Eur J Hum Genet. 2005 Mar;13(3):314-20
references.pmid: 15536479
references.citation: Rheumatology (Oxford). 2008 Jul;47(7):946-51
references.pmid: 18388145
references.citation: Clin Exp Immunol. 2002 Dec;130(3):484-8
references.pmid: 12452839
references.citation: Rheumatology (Oxford). 2001 May;40(5):579-84
references.pmid: 11371670
references.citation: Arthritis Rheum. 2010 Jan;62(1):258-67
references.pmid: 20039428
references.citation: Pediatr Infect Dis J. 1992 Apr;11(4):318-21
references.pmid: 1565557
references.citation: Cell. 1999 Apr 2;97(1):133-44
references.pmid: 10199409
references.citation: Lancet. 2006 Mar 25;367(9515):1016-24
references.pmid: 16564365
references.citation: Eur J Pediatr. 2009 Jul;168(7):825-31
references.pmid: 18839211
references.citation: Hum Mutat. 2004 Sep;24(3):194-8
references.pmid: 15300846
references.citation: J Inherit Metab Dis. 2006 Dec;29(6):763
references.pmid: 17103011
references.citation: Arch Pediatr. 2000 Jan;7(1):54-7
references.pmid: 10668087