Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum.
The left and right ventricular function of the heart are influenced by the complex structure of the ventricular septum. The cyclic variation of ultrasonic backscatter over the cardiac cycle is known to be sensitive to both structural and functional characteristics of the myocardium. The objective of this study was to investigate differences in the measured magnitude and normalized delay of cyclic variation between the left and right sides of the ventricular septum in normal adult subjects (N = 31). The measured mean magnitudes of cyclic variation were found to be 4.9 ± 0.4 dB and 2.4 ± 0.3 dB (mean ± SE; p < 0.0001) and the corresponding normalized delay values were found to be 0.94 ± 0.05 and 1.59 ± 0.12 (mean ± SE; p < 0.0001) for the left and right sides, respectively. These results show significant differences in the measured magnitude and normalized delay of cyclic variation between the left and right sides of the ventricular septum in normal subjects that appear consistent with predictions based on previously described models of cyclic variation of backscatter and reported measurements of transmural differences in strain properties of the septum.
Holland
Mark R
MR
Washington University, St. Louis, MO 63130, USA. mrh@wuphys.wustl.edu
Gibson
Allyson A
AA
Bauer
Adam Q
AQ
Peterson
Linda R
LR
Schaffer
Jean E
JE
Bach
Richard G
RG
Cresci
Sharon
S
Miller
James G
JG
D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D012016:Reference Values; D014463:Ultrasonography; D054088:Ventricular Septum / Q000033:anatomy & histology / Q000000981:diagnostic imaging*
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