Non-viral causes of hepatocellular carcinoma.
BACKGROUND
Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide. The vast majority of cases occur in individuals with a chronic HBV or HCV infection. In addition, a number of metabolic diseases of the liver are associated with the development of HCC.
The mechanisms responsible for the progression of the metabolic liver disease and HCC differ from those associated with viral liver disease.


CONCLUSIONS
The purpose of this report is to describe the mechanisms responsible for the disease progression and HCC in case of metabolic liver disease. A secondary goal is to identify the frequency of HCC development in the disorders described.
Van Thiel
David H
DH
Rush University Medical Center, Chicago, IL 60612, USA. david_vanthiel@rush.edu
Ramadori
Guiliano
G
D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology
Hepatology. 1997 Jul;26(1):155-64
9214465
Am J Gastroenterol. 1997 Mar;92(3):485-9
9068475
Carcinogenesis. 1992 Oct;13(10):1869-72
1330345
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4641-5
270706
Rev Gastroenterol Disord. 2002;2(1):11-9
12122975
N Engl J Med. 1986 Mar 20;314(12):736-9
3485248
Med J Aust. 2000 Nov 6;173(9):476-9
11149304
Clin Liver Dis. 2005 May;9(2):191-211, v
15831268
Alcohol Clin Exp Res. 1989 Dec;13(6):804-9
2557775
Hepatology. 1993 Dec;18(6):1326-33
8244256
Gut. 2002 Jul;51(1):132-9
12077107
J Hepatol. 2002 Dec;37(6):806-13
12445422
Clin Invest Med. 1996 Oct;19(5):311-6
8889268
Hepatology. 1994 Dec;20(6):1426-31
7982640
Int J Cancer. 2004 Jun 10;110(2):155-69
15069676
N Engl J Med. 1985 Nov 14;313(20):1256-62
4058506
Gastroenterology. 1996 Apr;110(4):1107-19
8613000
Gastroenterology. 2003 Mar;124(3):778-90
12612915
N Engl J Med. 1993 Jun 24;328(25):1797-801
7684822
Lancet. 2005 Sep 24-30;366(9491):1059-62
16182882
J Pediatr. 1995 Nov;127(5):700-4
7472819
Am J Gastroenterol. 2001 Aug;96(8):2462-7
11513191
Free Radic Biol Med. 2002 Jan 1;32(1):11-6
11755312
N Engl J Med. 2002 Apr 18;346(16):1221-31
11961152
Acta Med Scand. 1974 Jun;195(6):451-8
4365922
J Clin Gastroenterol. 1989 Apr;11(2):220-4
2472436
Trends Genet. 1997 Nov;13(11):444-9
9385841
Nutr Rev. 2002 Sep;60(9):289-93
12296456
Semin Liver Dis. 1995 Feb;15(1):64-9
7597445
Hepatology. 2000 Nov;32(5):970-9
11050047
N Engl J Med. 1999 Mar 11;340(10):745-50
10072408
Oncology. 2002;62 Suppl 1:8-17
11868791
Cancer Lett. 1994 Apr 29;79(1):9-16
7910516
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15584-9
12438687
J Hepatol. 2010 Apr;52(4):550-9
20206398
Ann Intern Med. 2003 Nov 18;139(10):817-23
14623619
Gastroenterology. 2002 Jul;123(1):134-40
12105842
J Clin Gastroenterol. 2003 Apr;36(4):356-9
12642745
Postgrad Med J. 1985 Apr;61(714):357-9
2991870
Gastroenterology. 2004 Nov;127(5 Suppl 1):S5-S16
15508102
Liver. 1992 Feb;12(1):42-5
1314321
N Engl J Med. 1997 Dec 11;337(24):1733-45
9392700
J Hepatol. 2002 Jul;37(1):154-60
12076877
J Inherit Metab Dis. 2002 May;25(3):227-34
12137232