title: Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA.
abstract: Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to find the exact cytotoxic mechanism of these 3-aryl-1-isoquinolinamines, we analyzed the cell cycle dynamics by flow cytometry and found that 3-aryl-1-isoquinolinamine 6k-treated HeLa cells were arrested in G2/M phase, which is related to apoptosis.
authors.affiliation: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Buk-gu, Gwangju 500-757, Korea.
authors.forename: Su Hui
authors.initials: SH
authors.lastname: Yang
authors.forename: Hue Thi My
authors.initials: HT
authors.lastname: Van
authors.forename: Thanh Nguyen
authors.initials: TN
authors.lastname: Le
authors.forename: Daulat Bikram
authors.initials: DB
authors.lastname: Khadka
authors.forename: Suk Hee
authors.initials: SH
authors.lastname: Cho
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Eung-Seok
authors.initials: ES
authors.lastname: Lee
authors.forename: Young Bok
authors.initials: YB
authors.lastname: Lee
authors.forename: Chang-Ho
authors.initials: CH
authors.lastname: Ahn
authors.forename: Won-Jea
authors.initials: WJ
authors.lastname: Cho
mesh_terms: D000588:Amines / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D007546:Isoquinolines