title: Variable evolutionary signatures at the heart of enhancers.
abstract: What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint.
authors.forename: Ross C
authors.initials: RC
authors.lastname: Hardison
mesh_terms: D004742:Enhancer Elements, Genetic / Q000235:genetics*; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D014644:Genetic Variation / Q000502:physiology*; D006321:Heart / Q000196:embryology / Q000254:growth & development; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D016415:Sequence Alignment; D013045:Species Specificity
references.citation: Science. 2010 May 21;328(5981):1036-40
references.pmid: 20378774
references.citation: Nature. 2007 Jun 14;447(7146):799-816
references.pmid: 17571346
references.citation: Nature. 2006 Nov 23;444(7118):499-502
references.pmid: 17086198
references.citation: Nat Rev Genet. 2005 Feb;6(2):151-7
references.pmid: 15716910
references.citation: Genome Res. 2007 Jun;17(6):760-74
references.pmid: 17567995
references.citation: Nat Genet. 2010 Sep;42(9):806-10
references.pmid: 20729851
references.citation: Nat Genet. 2007 Mar;39(3):311-8
references.pmid: 17277777
references.citation: Genome Res. 2007 Jun;17(6):775-86
references.pmid: 17567996