Chemerin: at the crossroads of inflammation and obesity.
Chemerin is a secreted protein with a complex but well-established role in immune function. Parallel lines of investigation also support the notion that chemerin is a novel adipokine that regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissues. A growing body of human experimental data indicates that serum chemerin levels are elevated in patients with obesity and that they exhibit a positive correlation with various aspects of the metabolic syndrome. Thus, the dual role of chemerin in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease.
Ernst
Matthew C
MC
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada, B3H1X5.
Sinal
Christopher J
CJ
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D018925:Chemokines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D005947:Glucose