Serum tumor markers in testicular cancer.
Testicular cancer has become a model for a curable neoplasm, where biochemical markers play a critical role. Serum tumor markers are integral in patient management and contributes to the diagnosis, staging, and risk assessment, as well as evaluation of response to therapy and detection of relapse. We review their biochemistry, biology, and clinical use in the setting of localized and metastatic disease. The integration of tumor markers in prognostic models as well as the significance of marker kinetics during chemotherapy is discussed.
Ehrlich
Yaron
Y
Department of Urology, School of Medicine, Melvin and Bren Simon Cancer Center, Indianapolis, IN 46292, USA. yaronehrlich@gmail.com
Beck
Stephen D W
SD
Foster
Richard S
RS
Bihrle
Richard
R
Einhorn
Lawrence H
LH
D015415:Biomarkers / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D011379:Prognosis; D013736:Testicular Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000628:therapy
D015415:Biomarkers; D014408:Biomarkers, Tumor