[Hybrid nanocarriers for controlled delivery of antitumour and retroviral drugs delivery].
The efficient delivery of drugs in the body requires the use of non-toxic nanocarriers. Most of the existing materials show poor drug loading and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. The new porous hybrid solids, with the ability to tune their structures and porosities are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III) - based metal - organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of antitumour and retroviral drugs against cancer and AIDS. They also potentially associate therapeutics and diagnostics, and open the way for theranostics, or -personalized patient treatments. double dagger.
Horcajada
Patricia
P
Institut Lavoisier, Université de Versailles- Saint-Quentin-en-Yvelines, 78035 Versailles, France.
Serre
Christian
C
Férey
Gérard
G
Couvreur
Patrick
P
Gref
Ruxandra
R
D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D002066:Busulfan / Q000737:chemistry / Q000627:therapeutic use; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D063065:Organophosphonates / Q000737:chemistry / Q000627:therapeutic use; D015215:Zidovudine / Q000737:chemistry / Q000627:therapeutic use
D044966:Anti-Retroviral Agents; D000970:Antineoplastic Agents; D004337:Drug Carriers; D063065:Organophosphonates; D015215:Zidovudine; D004317:Doxorubicin; D003596:Cytosine; D002066:Busulfan; D000077404:Cidofovir