Beneficial effect of Eucommia polysaccharides on systemic lupus erythematosus-like syndrome induced by Campylobacter jejuni in BALB/c mice.
The stem bark of Eucommia ulmoides Oliv. is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia in traditional Chinese medicine. This study was to determine whether the crude polysaccharides (EUPs) isolated from the stem bark of E. ulmoides had beneficial effects on lupus-like syndrome in mice. BALB/c mice were immunized with CJ-S(131) in Freund's complete adjuvant on day 0, and then boosted on day 14. EUPs 15 or 30 mg kg(-1)·day(-1), or prednisone 5 mg kg(-1)·day(-1) was given to BALB/c mice intragastrically from day 0 to 34. Treatment with EUPs 15 or 30 mg kg(-1)·day(-1) for 35 days protected kidney from glomerular injury with reduced immunoglobulin deposition and lowered proteinuria. The increased production of serum autoantibodies and total immunoglobulin G (IgG) was also inhibited. These findings suggested that Eucommia polysaccharides had a beneficial effect on systemic lupus erythematosus-like syndrome induced by CJ-S(131) in BALB/c mice.
Jiang
Long
L
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Wang
Zheng
Z
Zhu
Hong-Wei
HW
Di
Hong-Ye
HY
Li
Hong
H
Zhang
Yun-Yi
YY
Chen
Dao-Feng
DF
D000818:Animals; D001323:Autoantibodies / Q000097:blood; D016123:Campylobacter jejuni / Q000276:immunology / Q000472:pathogenicity; D051056:Complement Inactivating Agents / Q000302:isolation & purification / Q000627:therapeutic use; D004195:Disease Models, Animal; D031283:Eucommiaceae / Q000737:chemistry; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D013577:Syndrome
D001323:Autoantibodies; D051056:Complement Inactivating Agents; D007074:Immunoglobulin G; D011134:Polysaccharides
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