title: Synthesis of inherently chiral azacalix[4]arenes and diazadioxacalix[4]arenes.
abstract: Described are nucleophilic aromatic substitution reactions for the synthesis of inherently chiral azacalix[4]arenes and diazadioxacalix[4]arenes comprised of two or three different aromatic monomers. A variety of functional groups are tolerated at the 2-, 4-, and 5-positions on the nucleophilic-component monomers; reactions are run under ambient atmosphere; and the macrocycles are constructed without isolation of intermediate linear species.
authors.affiliation: Department of Chemistry, Colby College, 5754 Mayflower Hill, Waterville, Maine 04901, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Katz
authors.forename: Brittany A
authors.initials: BA
authors.lastname: Tschaen