Effects of resveratrol and flavonols on cardiovascular function: Physiological mechanisms.
Resveratrol and flavonols are commonly found together in fruits and vegetables and, therefore, consumed in the diet. These two polyphenols share both vasorelaxant and antioxidant activity and may act together to improve cardiovascular function. This review examines the mechanisms by which resveratrol and flavonols influence cardiovascular function and perhaps offer a new approach for the development of therapeutic agents for the prevention and/or treatment of coronary artery disease.
Yap
Suwan
S
University of Melbourne, Parkville, VIC, Australia.
Qin
Chengxue
C
Woodman
Owen L
OL
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D004032:Diet; D004730:Endothelium, Vascular / Q000187:drug effects; D004789:Enzyme Activation; D044948:Flavonols / Q000494:pharmacology*; D005638:Fruit; D006801:Humans; D011794:Quercetin / Q000494:pharmacology; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000494:pharmacology; D014675:Vegetables
D000975:Antioxidants; D002316:Cardiotonic Agents; D044948:Flavonols; D013267:Stilbenes; D014665:Vasodilator Agents; D011794:Quercetin; D056564:Sirtuin 1; D000077185:Resveratrol; C529890:3',4'-dihydroxyflavonol