A novel hepatoprotective saponin from Celosia cristata L.
A new saponin, cristatain (1), together with four other saponins, celosin A (2), celosin B (3), celosin C (4) and celosin D (5) were isolated from the seeds of Celosia cristata L. (Amaranthaceae). Their structures were established by chemical and spectroscopic analyses. For the first time, the saponins were found in C. cristata L. In addition, compound 1 exhibited significant hepatoprotective effect on carbon tetrachloride (CCl(4))- and N,N-dimethylformamide (DMF)-induced hepatotoxicity in mice, which were evidenced by significant decreases in the values of asparate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) of serum and histopathological examinations compared to controls.
Wang
Yan
Y
Department of Pharmacognosy, College of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
Lou
Ziyang
Z
Wu
Qing-Bin
QB
Guo
Mei-Li
ML
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D034762:Celosia / Q000737:chemistry*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004126:Dimethylformamide / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D011897:Random Allocation; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
D012503:Saponins; D004126:Dimethylformamide; D002251:Carbon Tetrachloride