The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key.
This Commentary discusses how suppressor of glucose by autophagy (SOGA) contributes to adiponectin-mediated insulin-dependent inhibition of autophagy during the activation of adenosine monophosphate kinase (AMPK).
Forbes
Josephine M
JM
Diabetes Division, Baker IDI Heart and Diabetes Institute, and the Department of Immunology, Monash University, Melbourne, Australia. josephine.forbes@bakeridi.edu.au
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D052242:Adiponectin / Q000494:pharmacology; D000818:Animals; D001343:Autophagy; D005943:Gluconeogenesis / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
D052242:Adiponectin; D055372:AMP-Activated Protein Kinases; D005947:Glucose
FEBS Lett. 1993 Oct 25;333(1-2):169-74
8224160
Autophagy. 2007 May-Jun;3(3):238-40
17224623
J Biol Chem. 2006 Nov 17;281(46):34870-9
16990266
Nature. 2004 Apr 1;428(6982):569-74
15058305
J Clin Endocrinol Metab. 2004 Jun;89(6):2563-8
15181024
N Engl J Med. 2004 Feb 12;350(7):664-71
14960743
Annu Rev Nutr. 1987;7:539-64
3300746
Cell Tissue Res. 1986;243(3):641-8
3955637
J Biol Chem. 2004 Feb 27;279(9):8452-9
14610086
Nat Cell Biol. 2007 Feb;9(2):218-24
17237771
Am J Pathol. 2010 Oct;177(4):1936-45
20813965
Cell Death Differ. 2005 Nov;12 Suppl 2:1542-52
16247502
Annu Rev Pathol. 2008;3:427-55
18039129
J Biol Chem. 2004 Apr 16;279(16):15719-22
14970221
Nature. 2009 Apr 30;458(7242):1131-5
19339967
J Clin Invest. 1974 Jul;54(1):188-93
4834889
J Clin Invest. 2001 Dec;108(12):1875-81
11748271
Nat Med. 2002 Nov;8(11):1288-95
12368907
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16309-13
12456889
Physiol Rev. 2006 Jan;86(1):205-43
16371598
Cell Metab. 2005 Jan;1(1):15-25
16054041
Annu Rev Nutr. 2007;27:19-40
17311494
Endocr Rev. 2004 Oct;25(5):807-30
15466941