title: Symptom cluster and quality of life: preliminary evidence in multiple sclerosis.
abstract: This study examined the symptom cluster of fatigue, pain, and depression as a correlate of reduced quality of life (QOL) in individuals with multiple sclerosis (MS). The sample included 291 individuals with a definite diagnosis of MS who were enrolled in a 6-month longitudinal study of physical activity and QOL. The participants completed baseline measures of fatigue, depression, and pain and follow-up measures of QOL. Cluster analysis initially identified three subgroups differing in experiences of fatigue, depression, and pain, and analysis of variance then indicated that the three subgroups differed in QOL. The subgroup with lowest scores on all three symptoms had the highest QOL, whereas the subgroup with the highest scores on the symptoms had the worst QOL. Such findings provide preliminary support for fatigue, pain, and depression as a symptom cluster that correlates with reduced QOL in persons with MS.
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois, Urbana, IL, USA. robmotl@uiuc.edu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Motl
authors.forename: Edward
authors.initials: E
authors.lastname: McAuley
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001294:Attitude to Health; D016000:Cluster Analysis; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D005163:Factor Analysis, Statistical; D005221:Fatigue / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015146:Midwestern United States / Q000453:epidemiology; D009103:Multiple Sclerosis / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D015404:Nursing Methodology Research; D010146:Pain / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
references.citation: Clin Rehabil. 2001 Jun;15(3):247-58
references.pmid: 11386394
references.citation: Arch Neurol. 1989 Oct;46(10):1121-3
references.pmid: 2803071
references.citation: J Natl Cancer Inst Monogr. 2007;(37):39-46
references.pmid: 17951230
references.citation: Psychol Health Med. 2009 Jan;14(1):111-24
references.pmid: 19085318
references.citation: Oncol Nurs Forum. 2001 Apr;28(3):465-70
references.pmid: 11338755
references.citation: J Pain Symptom Manage. 2009 Aug;38(2):270-80
references.pmid: 19329276
references.citation: Neurol Clin. 2005 Feb;23(1):1-15, v
references.pmid: 15661085
references.citation: Clin Ther. 2006 Apr;28(4):445-60
references.pmid: 16750459
references.citation: J Neurol Neurosurg Psychiatry. 2006 Jan;77(1):34-9
references.pmid: 16361589
references.citation: J Pers Assess. 1985 Feb;49(1):71-5
references.pmid: 16367493
references.citation: Semin Oncol Nurs. 2007 May;23(2):89-98
references.pmid: 17512435
references.citation: Acta Psychiatr Scand. 1983 Jun;67(6):361-70
references.pmid: 6880820
references.citation: Oncol Nurs Forum. 2006 Sep 01;33(5):E79-89
references.pmid: 16955115
references.citation: Lancet Neurol. 2005 Sep;4(9):556-66
references.pmid: 16109362
references.citation: Pain. 1987 Aug;30(2):191-197
references.pmid: 3670870
references.citation: J Pain Symptom Manage. 2008 Feb;35(2):162-70
references.pmid: 18082357
references.citation: Clin Rehabil. 2006 Jan;20(1):67-78
references.pmid: 16502752