title: Whole-genomic survey of oligodendroglial tumors: correlation between allelic imbalances and gene expression profiles.
abstract: Malignant gliomas are the most common subtype of primary central nervous system (CNS) tumors. Their pathological classification, however, remains subjective, stimulating researchers to actively seek objective molecular markers to discover alternative and more reproducible tools for improved subtypification. Herein, we present a global survey of genomic alterations in oligodendroglial tumors (OT). Genetic and epigenetic alterations identified in this study are correlated with OT molecular groups we have recently reported: a neurogenic group composed of tumors with loss of heterozygosity (LOH) at 1p-19q, IDH1 mutations, and MGMT promoter methylation, showing good prognosis; an intermediate group, presenting TP53 mutations or LOH at 17p, IDH1 mutations, and GSTP1 promoter methylation; and a proliferative group, presenting major genetic alterations (LOH at 10q, EGFR amplification, and CDKN2A/ARF deletion) and poor prognosis. These results allowed us to refine our molecular characterization associated with prognosis, referring exclusively to oligodendroglial tumors.
authors.affiliation: Department of Physical-Chemistry, Universitat de Valencia, Dr. Moliner sn, 46100 Burjassot, Valencia, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Ferrer-Luna
authors.forename: Lina
authors.initials: L
authors.lastname: Núñez
authors.forename: José
authors.initials: J
authors.lastname: Piquer
authors.forename: Eugenia
authors.initials: E
authors.lastname: Arias
authors.forename: Francisco
authors.initials: F
authors.lastname: Dasí
authors.forename: Andrés
authors.initials: A
authors.lastname: Cervio
authors.forename: Naomi
authors.initials: N
authors.lastname: Arakaki
authors.forename: Gustavo
authors.initials: G
authors.lastname: Sevlever
authors.forename: Bernardo
authors.initials: B
authors.lastname: Celda
authors.forename: Horacio
authors.initials: H
authors.lastname: Martinetto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D022981:Allelic Imbalance; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000235:genetics*; D002675:Child, Preschool; D002877:Chromosomes, Human / Q000235:genetics; D019175:DNA Methylation; D057890:Epigenomics; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009837:Oligodendroglioma / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger
references.citation: Cancer Res. 2005 Dec 15;65(24):11335-44
references.pmid: 16357140
references.citation: J Clin Oncol. 2006 Oct 10;24(29):4746-53
references.pmid: 16954518
references.citation: Cancer Res. 2000 Nov 1;60(21):5954-8
references.pmid: 11085511
references.citation: JAMA. 2009 Jul 15;302(3):261-75
references.pmid: 19602686
references.citation: Acta Neuropathol. 2010 Apr;119(4):487-94
references.pmid: 20127344
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15785-90
references.pmid: 16243968
references.citation: Genome Biol. 2001;2(8):RESEARCH0032
references.pmid: 11532216
references.citation: Cancer Res. 2003 Apr 1;63(7):1602-7
references.pmid: 12670911
references.citation: J Neuropathol Exp Neurol. 2006 Oct;65(10):988-94
references.pmid: 17021403
references.citation: Clin Cancer Res. 2002 Jan;8(1):196-201
references.pmid: 11801559
references.citation: PLoS One. 2009;4(1):e4107
references.pmid: 19119320
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20007-12
references.pmid: 18077431
references.citation: Cancer Res. 2006 Oct 1;66(19):9428-36
references.pmid: 17018597
references.citation: Brain Pathol. 2010 Mar;20(2):298-300
references.pmid: 19744125
references.citation: Mol Cancer. 2008 May 20;7:41
references.pmid: 18492260
references.citation: J Neurooncol. 2009 Dec;95(3):343-354
references.pmid: 19597701
references.citation: Ann Neurol. 2007 May;61(5):484-90
references.pmid: 17469128
references.citation: Brain Pathol. 2008 Jul;18(3):360-9
references.pmid: 18371182
references.citation: PLoS Comput Biol. 2006 May;2(5):e41
references.pmid: 16699594
references.citation: Nucleic Acids Res. 1998 Nov 1;26(21):5009-10
references.pmid: 9776768
references.citation: Oncologist. 2009 Feb;14(2):155-63
references.pmid: 19182242
references.citation: N Engl J Med. 2000 Nov 9;343(19):1350-4
references.pmid: 11070098
references.citation: J Neuropathol Exp Neurol. 1999 Jun;58(6):606-12
references.pmid: 10374751
references.citation: Acta Neuropathol. 2007 Aug;114(2):97-109
references.pmid: 17618441
references.citation: Cancer Res. 2009 Feb 15;69(4):1596-603
references.pmid: 19190341
references.citation: Acta Neuropathol. 2002 Mar;103(3):267-75
references.pmid: 11907807
references.citation: Nucleic Acids Res. 2007;35(18):e119
references.pmid: 17855397
references.citation: Cancer. 2005 Oct 1;104(7):1468-77
references.pmid: 16088966
references.citation: Bioinformatics. 2004 May 22;20(8):1233-40
references.pmid: 14871870
references.citation: J Neurooncol. 2004 Nov;70(2):161-81
references.pmid: 15674476
references.citation: Cancer Res. 2001 Sep 15;61(18):6713-5
references.pmid: 11559541
references.citation: Am J Pathol. 1994 Nov;145(5):1175-90
references.pmid: 7977648
references.citation: Nature. 2009 Dec 10;462(7274):739-44
references.pmid: 19935646
references.citation: Am J Pathol. 1999 Aug;155(2):375-86
references.pmid: 10433931
references.citation: Cancer Sci. 2009 Dec;100(12):2235-41
references.pmid: 19737147
references.citation: Int J Cancer. 2005 Jan 20;113(3):379-85
references.pmid: 15455350
references.citation: J Clin Oncol. 2000 Feb;18(3):636-45
references.pmid: 10653879
references.citation: Cancer Res. 2009 Dec 15;69(24):9157-9
references.pmid: 19996293
references.citation: J Neuropathol Exp Neurol. 2001 Aug;60(8):808-16
references.pmid: 11487055
references.citation: J Neuropathol Exp Neurol. 1997 Oct;56(10):1098-104
references.pmid: 9329453
references.citation: Nature. 2008 Oct 23;455(7216):1061-8
references.pmid: 18772890
references.citation: Cancer Res. 2000 Sep 1;60(17):4812-8
references.pmid: 10987291
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6
references.pmid: 11134512
references.citation: J Pathol. 1999 Jul;188(3):282-8
references.pmid: 10419597
references.citation: Clin Cancer Res. 2001 Apr;7(4):839-45
references.pmid: 11309331
references.citation: J Pathol. 2001 May;194(1):81-7
references.pmid: 11329145
references.citation: Cancer Genet Cytogenet. 2009 Oct;194(1):12-22
references.pmid: 19737649
references.citation: Oncogene. 2002 Jun 6;21(25):3961-8
references.pmid: 12037678
references.citation: Cancer Res. 2004 May 1;64(9):3060-71
references.pmid: 15126342