title: Workshop on idiopathic pulmonary fibrosis in older adults.
abstract: Idiopathic pulmonary fibrosis (IPF), a heterogeneous disease with respect to clinical presentation and rates of progression, disproportionately affects older adults. The diagnosis of IPF is descriptive, based on clinical, radiologic, and histopathologic examination, and definitive diagnosis is hampered by poor interobserver agreement and lack of a consensus definition. There are no effective treatments. Cellular, molecular, genetic, and environmental risk factors have been identified for IPF, but the initiating event and the characteristics of preclinical stages are not known. IPF is predominantly a disease of older adults, and the processes underlying normal aging might significantly influence the development of IPF. Yet, the biology of aging and the principles of medical care for this population have been typically ignored in basic, translational, or clinical IPF research. In August 2009, the Association of Specialty Professors, in collaboration with the American College of Chest Physicians, the American Geriatrics Society, the National Institute on Aging, and the National Heart, Lung, and Blood Institute, held a workshop, summarized herein, to review what is known, to identify research gaps at the interface of aging and IPF, and to suggest priority areas for future research. Efforts to answer the questions identified will require the integration of geriatrics, gerontology, and pulmonary research, but these efforts have great potential to improve care for patients with IPF.
authors.affiliation: University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Castriotta
authors.forename: Basil A
authors.initials: BA
authors.lastname: Eldadah
authors.forename: W Michael
authors.initials: WM
authors.lastname: Foster
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Halter
authors.forename: William R
authors.initials: WR
authors.lastname: Hazzard
authors.forename: James P
authors.initials: JP
authors.lastname: Kiley
authors.forename: Talmadge E
authors.initials: TE
authors.lastname: King
authors.forename: Frances McFarland
authors.initials: FM
authors.lastname: Horne
authors.forename: Susan G
authors.initials: SG
authors.lastname: Nayfield
authors.forename: Herbert Y
authors.initials: HY
authors.lastname: Reynolds
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Schmader
authors.forename: Galen B
authors.initials: GB
authors.lastname: Toews
authors.forename: Kevin P
authors.initials: KP
authors.lastname: High
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D035843:Biomedical Research / Q000458:organization & administration*; D005853:Geriatrics / Q000458:organization & administration*; D006292:Health Priorities / Q000458:organization & administration*; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008875:Middle Aged
references.citation: J Am Geriatr Soc. 2008 Dec;56(12):2171-9
references.pmid: 19093915
references.citation: Chest. 2009 Sep;136(3):772-778
references.pmid: 19567497
references.citation: Am J Respir Crit Care Med. 2007 Oct 1;176(7):636-43
references.pmid: 17585107
references.citation: Am J Respir Crit Care Med. 2008 Oct 1;178(7):729-37
references.pmid: 18635888
references.citation: Rev Neurosci. 2009;20(1):23-37
references.pmid: 19526732
references.citation: J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M461-7
references.pmid: 12730257
references.citation: J Am Geriatr Soc. 2003 Apr;51(4):451-8
references.pmid: 12657063
references.citation: Ann Thorac Surg. 2004 Oct;78(4):1142-51; discussion 1142-51
references.pmid: 15464462
references.citation: Am J Respir Cell Mol Biol. 2005 Aug;33(2):145-52
references.pmid: 15891110
references.citation: Am J Respir Crit Care Med. 2002 Aug 15;166(4):510-3
references.pmid: 12186829
references.citation: Can Respir J. 2005 Sep;12(6):317-20
references.pmid: 16247529
references.citation: J Clin Invest. 2004 Aug;114(3):438-46
references.pmid: 15286810
references.citation: N Engl J Med. 2005 Nov 24;353(21):2229-42
references.pmid: 16306520
references.citation: Fibrogenesis Tissue Repair. 2008 Oct 13;1(1):2
references.pmid: 19014649
references.citation: Am J Respir Crit Care Med. 2001 Oct 1;164(7):1171-81
references.pmid: 11673205
references.citation: Am J Respir Crit Care Med. 2008 Oct 15;178(8):838-46
references.pmid: 18635891
references.citation: J Gerontol A Biol Sci Med Sci. 2000 Dec;55(12):M716-24
references.pmid: 11129393
references.citation: J Thorac Cardiovasc Surg. 2006 Feb;131(2):438-46
references.pmid: 16434276
references.citation: Arch Intern Med. 2004 Mar 8;164(5):551-6
references.pmid: 15006833
references.citation: PLoS One. 2009;4(4):e5134
references.pmid: 19347046
references.citation: Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80
references.pmid: 18187693
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Jul;64(7):731-9
references.pmid: 19359440
references.citation: Eur Respir J. 2005 Oct;26(4):586-93
references.pmid: 16204587
references.citation: Chest. 2009 Apr;135(4):929-935
references.pmid: 19017875
references.citation: Chest. 2006 Mar;129(3):746-52
references.pmid: 16537877
references.citation: Am J Respir Cell Mol Biol. 2006 Oct;35(4):466-73
references.pmid: 16709958
references.citation: J Am Coll Surg. 2009 Mar;208(3):400-9
references.pmid: 19318002
references.citation: Am J Respir Cell Mol Biol. 2003 Aug;29(2):213-24
references.pmid: 12649121
references.citation: Am J Respir Crit Care Med. 2005 May 1;171(9):1040-7
references.pmid: 15665326
references.citation: Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64
references.pmid: 10673212
references.citation: Am J Transplant. 2009 Apr;9(4 Pt 2):942-58
references.pmid: 19341417
references.citation: Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L525-34
references.pmid: 17631612
references.citation: Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L949-56
references.pmid: 12842806
references.citation: Am J Respir Cell Mol Biol. 2009 Mar;40(3):268-76
references.pmid: 18723441
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15960-4
references.pmid: 16247010
references.citation: J Pediatr (Rio J). 2007 May-Jun;83(3):233-40
references.pmid: 17551654
references.citation: Chest. 2003 Jun;123(6):2007-11
references.pmid: 12796182
references.citation: Eur Respir J. 2010 Jan;35(1):105-11
references.pmid: 19643948
references.citation: Thorax. 2000 Nov;55(11):958-61
references.pmid: 11050267
references.citation: Chest. 2004 Apr;125(4):1224-38
references.pmid: 15078729
references.citation: Respir Med. 2010 Feb;104(2):305-9
references.pmid: 19782552
references.citation: Chest. 2009 Feb;135(2):442-447
references.pmid: 18849399
references.citation: Proc Natl Acad Sci U S A. 2007 May 1;104(18):7552-7
references.pmid: 17460043
references.citation: Int J Biochem Cell Biol. 2008;40(10):2129-40
references.pmid: 18374622
references.citation: Respiration. 2008;76(3):288-94
references.pmid: 18216461
references.citation: Milbank Q. 2004;82(4):661-87
references.pmid: 15595946
references.citation: Eur Respir J. 2006 Jan;27(1):136-42
references.pmid: 16387946
references.citation: Biochem Biophys Res Commun. 2007 Feb 2;353(1):104-8
references.pmid: 17174272
references.citation: Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L711-21
references.pmid: 15734789
references.citation: Proc Am Thorac Soc. 2006 Jun;3(4):285-92
references.pmid: 16738191
references.citation: Am J Respir Crit Care Med. 2007 May 15;175(10):1054-60
references.pmid: 17255566
references.citation: Am J Respir Cell Mol Biol. 2005 Jul;33(1):9-13
references.pmid: 15964990
references.citation: PLoS One. 2007 May 30;2(5):e482
references.pmid: 17534432
references.citation: Int J Biochem Cell Biol. 2008;40(3):362-82
references.pmid: 17936056
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8407-11
references.pmid: 12815096
references.citation: Ageing Res Rev. 2009 Jul;8(3):150-9
references.pmid: 19491040
references.citation: Am J Respir Crit Care Med. 2006 Sep 15;174(6):659-64
references.pmid: 16778159
references.citation: Am J Respir Crit Care Med. 2001 Jan;163(1):61-8
references.pmid: 11208627
references.citation: Am J Respir Crit Care Med. 2005 Nov 1;172(9):1146-52
references.pmid: 16109978
references.citation: Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304
references.pmid: 11790668
references.citation: J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):286-95
references.pmid: 17389726
references.citation: Am J Pathol. 2005 May;166(5):1321-32
references.pmid: 15855634
references.citation: J Appl Physiol (1985). 2006 Jul;101(1):30-9
references.pmid: 16469934
references.citation: Am J Transplant. 2006;6(5 Pt 2):1212-27
references.pmid: 16613597
references.citation: Am J Respir Crit Care Med. 2007 Jun 1;175(11):1139-50
references.pmid: 17363768
references.citation: Chest. 2005 Oct;128(4):2393-9
references.pmid: 16236900
references.citation: Histopathology. 2009 Jan;54(1):90-103
references.pmid: 19054158
references.citation: Chest. 2002 Oct;122(4 Suppl):1S-269S
references.pmid: 12392000
references.citation: Chest. 2006 Mar;129(3):794-800
references.pmid: 16537884
references.citation: Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L805-12
references.pmid: 19648289
references.citation: J Exp Med. 2004 Aug 2;200(3):377-89
references.pmid: 15289506
references.citation: Am J Respir Cell Mol Biol. 1995 May;12(5):497-502
references.pmid: 7742013
references.citation: Ann Thorac Surg. 2005 Mar;79(3):950-7; discussion 957-8
references.pmid: 15734411
references.citation: Chest. 2007 Sep;132(3):773-9
references.pmid: 17573485
references.citation: Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1061-9
references.pmid: 10194146
references.citation: Am J Respir Crit Care Med. 2006 Jan 15;173(2):188-98
references.pmid: 16166619
references.citation: Am J Respir Crit Care Med. 2008 Jan 1;177(1):75-81
references.pmid: 17901413
references.citation: Cochrane Database Syst Rev. 2003;(3):CD002880
references.pmid: 12917934
references.citation: Am J Transplant. 2006 Feb;6(2):398-403
references.pmid: 16426327
references.citation: J Clin Microbiol. 2003 Jun;41(6):2633-40
references.pmid: 12791891
references.citation: Proc Am Thorac Soc. 2006 Jun;3(4):364-72
references.pmid: 16738202
references.citation: Am J Respir Crit Care Med. 2009 Jul 15;180(2):167-75
references.pmid: 19363140
references.citation: Am J Respir Cell Mol Biol. 2006 Aug;35(2):175-81
references.pmid: 16543609
references.citation: J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):829-34
references.pmid: 18772470
references.citation: Am J Respir Crit Care Med. 2008 Dec 15;178(12):1257-61
references.pmid: 18755924
references.citation: J Cell Biochem. 2008 Oct 15;105(3):641-7
references.pmid: 18759327
references.citation: Am J Respir Crit Care Med. 2009 Oct 1;180(7):657-65
references.pmid: 19556518
references.citation: Histochem Cell Biol. 2008 Nov;130(5):979-92
references.pmid: 18633634
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13180-5
references.pmid: 16924102
references.citation: JAMA. 2006 Feb 15;295(7):801-8
references.pmid: 16478903
references.citation: Ann Intern Med. 2005 Jun 21;142(12 Pt 1):963-7
references.pmid: 15968010
references.citation: PLoS One. 2009 Oct 23;4(10):e7559
references.pmid: 19851501
references.citation: Chest. 2009 Jul;136(1):10-15
references.pmid: 19225068
references.citation: PLoS Med. 2005 Sep;2(9):e251
references.pmid: 16128620
references.citation: Nucleic Acids Res. 2007;35(22):7406-16
references.pmid: 17913752
references.citation: Respir Med. 2009 Jun;103(6):927-31
references.pmid: 19058956
references.citation: Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1119-26
references.pmid: 18390830
references.citation: Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1183-93
references.pmid: 17720875
references.citation: Vet Pathol. 2007 Nov;44(6):849-62
references.pmid: 18039898
references.citation: J Transl Med. 2008 Apr 10;6:16
references.pmid: 18402687
references.citation: J Thorac Cardiovasc Surg. 2003 Mar;125(3):533-42
references.pmid: 12658195