The Role of Adipokines in Understanding the Associations between Obesity and Depression.
Objective. Two major causes of disability, major depression and obesity, share overlapping psychosocial and pathophysiological etiologies. Studies are now focused on biological mechanisms linking the two illnesses, and there is interest in the role that adipokines may have in mediating the association between obesity and depression. We reviewed the literature to look at what is currently known about this association, focusing on the adipokines leptin, adiponectin, and resistin. Methods. A MEDLINE search, citing articles from 1966 onward, supplemented by a review of bibliographies, was conducted to identify relevant studies. Results. This paper identified plausible pathways underlying a link between adipokines and depression. Only a few studies have yet been conducted specifically examining these biomarkers in patients with depression, but the results are intriguing. Conclusion. This paper is one of the first to examine the association between adipokines and depression. It provides an overview of the physiological role of adipokines and summarizes the data suggesting that they may be dysregulated in major depression. This area of research may become increasingly important as new treatment strategies are developed.
Taylor
Valerie H
VH
Mood Disorders Program, Centre for Mountain Health Services, McMaster University, D150-A, 100 West 5th Street, St. Joseph's Healthcare, Hamilton, ON, Canada L8N 3K7.
Macqueen
Glenda M
GM
J Diabetes Complications. 2003 Mar-Apr;17(2):108-13
12614978
Proc Nutr Soc. 2002 Nov;61(4):473-87
12691177
J Clin Psychiatry. 2009 Aug;70(8):1078-90
19497250
Psychosom Med. 2005 May-Jun;67 Suppl 1:S26-8
15953796
CNS Drugs. 2001;15(5):361-73
11475942
Curr Opin Pharmacol. 2007 Dec;7(6):648-52
18032111
Pharmacol Biochem Behav. 2006 Oct;85(2):474-9
17126386
Psychiatry Res. 2002 Dec 30;113(3):255-68
12559482
Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
10092513
Trends Endocrinol Metab. 2002 Mar;13(2):84-9
11854024
Eur J Endocrinol. 2004 Mar;150(3):339-44
15012619
Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33
12736161
FEBS Lett. 2005 Sep 26;579(23):5163-9
16140297
J Clin Psychiatry. 2010 Aug;71(8):1007-16
20156411
N Engl J Med. 1991 Aug 29;325(9):606-12
1713648
J Comp Neurol. 1998 Jun 15;395(4):535-47
9619505
J Clin Endocrinol Metab. 2003 Jun;88(6):2714-8
12788878
J Affect Disord. 1988 May-Jun;14(3):213-22
2838538
Br J Psychiatry. 1991 Jan;158:59-63
1673078
Dig Dis Sci. 2009 Sep;54(9):1847-56
19052866
Biochem Biophys Res Commun. 2002 Jan 25;290(3):1084-9
11798186
Psychosom Med. 2001 Mar-Apr;63(2):267-72
11292274
PLoS One. 2008 Jan 02;3(1):e1392
18167551
Nature. 2001 Jan 18;409(6818):292-3
11201721
Clin Sci (Lond). 2005 Sep;109(3):243-56
16104844
Ann N Y Acad Sci. 2010 Apr;1193:160-3
20398023
J Hepatol. 2006 Mar;44(3):537-43
16310276
Physiol Res. 2003;52(1):61-6
12625808
Neuroendocrinology. 2001 Apr;73(4):243-7
11340338
Neurosci Lett. 2006 Oct 30;407(3):211-3
16973279
Eur J Endocrinol. 2002 Nov;147(5):571-4
12444887
Nat Rev Cancer. 2004 Aug;4(8):579-91
15286738
Eur J Pharmacol. 2004 Jun 16;493(1-3):41-4
15189762
Med Hypotheses. 2008;70(4):902-3
17920209
Nat Neurosci. 2005 May;8(5):566-70
15856064
J Biol Chem. 2001 Jul 13;276(28):25651-3
11373275
Diabetes Obes Metab. 2004 May;6(3):163-70
15056123
Horm Metab Res. 1996 Dec;28(12):714-7
9013749
Int J Obes (Lond). 2006 Jan;30(1):6-13
16344843
Ann Intern Med. 2001 Aug 21;135(4):306-7
11511160
Acta Psychiatr Scand Suppl. 2007;(433):58-71
17280572
Mediators Inflamm. 2010;2010:573594
20490354
Br J Nutr. 2004 Sep;92(3):347-55
15469638
Int J Obes Relat Metab Disord. 2003 Aug;27(8):875-88
12861227
Mol Cell Endocrinol. 2010 Mar 25;316(2):154-64
19804814
Biochem Biophys Res Commun. 2001 Dec 21;289(5):1328-33
11741341
Obes Res. 2002 Nov;10(11):1095-103
12429872
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1159-62
16678955
J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):414-9
18426966
Mol Psychiatry. 2006 Oct;11(10):892-902
16880826
J Clin Invest. 2005 May;115(5):1111-9
15864338
EMBO J. 2000 Aug 1;19(15):4046-55
10921885
J Clin Invest. 2000 Jun;105(12):1827-32
10862798
Biochem Biophys Res Commun. 2003 Feb 21;301(4):1045-50
12589818
Brain Behav Immun. 2003 Aug;17(4):276-85
12831830
Forum Nutr. 2010;63:123-132
19955780
J Psychiatr Res. 1998 Nov-Dec;32(6):403-10
9844957
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1593-8
16423896
J Psychiatr Res. 2007 Apr-Jun;41(3-4):344-50
16497334
Curr Diab Rep. 2003 Aug;3(4):293-8
12866991
BMJ. 1998 Dec 12;317(7173):1608-9
9848897
N Engl J Med. 2001 Nov 1;345(18):1345-6
11794158
Mol Cell Endocrinol. 2010 Mar 25;316(2):129-39
19723556
Ann N Y Acad Sci. 2004 Dec;1032:1-7
15677391
Expert Opin Ther Targets. 2005 Apr;9(2):245-51
15934913
J Affect Disord. 2006 Jan;90(1):21-7
16324751
Curr Opin Lipidol. 2003 Dec;14(6):561-6
14624132
Endocrinology. 2004 Dec;145(12):5589-97
15319349
Nature. 2001 Jan 18;409(6818):307-12
11201732
J Clin Invest. 2003 Jan;111(2):225-30
12531878