Contribution of chitinases to Listeria monocytogenes pathogenesis.
Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.
Chaudhuri
Swarnava
S
UIC Department of Microbiology and Immunology (MC790), 835 S. Wolcott Ave., Chicago, IL 60612-7344, USA.
Bruno
Joseph C
JC
Alonzo
Francis
F
Xayarath
Bobbi
B
Cianciotto
Nicholas P
NP
Freitag
Nancy E
NE
D000818:Animals; D018938:Caco-2 Cells / Q000382:microbiology; D002686:Chitin / Q000378:metabolism; D002688:Chitinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008089:Listeria monocytogenes / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D008088:Listeriosis / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000382:microbiology
D002686:Chitin; D002688:Chitinases
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