[State of antiendotoxin defense during community-acquired pneumonia].
OBJECTIVE
To assess the effect of systemic endotoxinemia and LPS-induced immune response on severity of community-acquired pneumonia (CAP).


METHODS
Clinico-immunological follow-up of 60 patients with CAP of different severity was conducted. LPS was quantitatively measured by ENDOSAFE ENDOCHROME (0.015-0.12 EU/ml), LBP--by Hbt Human LBP ELISA (min 1 ng/ml), IgG to core region of LPS--by Hbt EndoCAb ELISA (min 0.125 MU/ml) ("HyCult biotechnology", Netherlands).


RESULTS
Level of LPS in blood was not increased, whereas there was increase of antiendotoxin proteins in patients with more severe CAP with Gram-negative or mixed bacterial flora identified. Correlation between levels of LBP, IgG to core-region of LPS, IL-6, TNF-alpha, IL-4 and immune response abnormalities during severe forms of disease was demonstrated.


CONCLUSIONS
State of antiendotoxin immunity is an etiologic marker of CAP and its severity.
Mavziutova
G A
GA
Fazlyeva
R M
RM
Mavziutov
A R
AR
Khaĭrullina
R M
RM
Akbasheva
A O
AO
Kuzovkina
O Z
OZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D017714:Community-Acquired Infections / Q000097:blood / Q000276:immunology*; D016207:Cytokines / Q000097:blood; D019446:Endotoxemia / Q000097:blood / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000097:blood / Q000276:immunology*; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood* / Q000276:immunology
D000907:Antibodies, Bacterial; D015415:Biomarkers; D016207:Cytokines; D004731:Endotoxins; D008070:Lipopolysaccharides