title: Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster.
abstract: Polyoxins consist of 14 structurally variable components which differentiate at three branch sites of the carbon skeleton. Open reading frame (ORF) SAV_4805 of Streptomyces avermitilis, showing similarity to thymine-7-hydroxylase, was proved to enhance the diversity of polyoxins at the C-5 site of the 1-(5'-amino-5'-deoxy-β-d-allofuranuronosyl) pyrimidine moiety.
authors.affiliation: Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030, China.
authors.forename: Changming
authors.initials: C
authors.lastname: Zhao
authors.forename: Tingting
authors.initials: T
authors.lastname: Huang
authors.forename: Wenqing
authors.initials: W
authors.lastname: Chen
authors.forename: Zixin
authors.initials: Z
authors.lastname: Deng
mesh_terms: D000935:Antifungal Agents / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics; D006899:Mixed Function Oxygenases / Q000235:genetics* / Q000378:metabolism; D005810:Multigene Family / Q000235:genetics; D016366:Open Reading Frames / Q000235:genetics; D011741:Pyrimidine Nucleosides / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D011741:Pyrimidine Nucleosides; C002457:polyoxin; D006899:Mixed Function Oxygenases; C023164:thymine, 2-oxoglutarate dioxygenase
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