title: Social appraisal in chronic psychosis: role of medial frontal and occipital networks.
abstract: Persons with schizophrenia often appraise other individuals as threatening or persecutory. To evaluate social appraisal in schizophrenia, we probed brain networks with a task in which subjects judged whether or not they liked face stimuli with emotional expressions. We predicted that appraising negative expressions would engage patients, more than controls, and negative faces would be related to higher levels of negative affect and produce increased activity in the medial frontal cortex, an area involved in social appraisal. Twenty-one stable outpatients with chronic non-affective psychosis (16 schizophrenic, 5 schizoaffective) and 21 healthy subjects underwent functional magnetic resonance imaging. Compared with the control subjects, patients were slower to respond, but particularly slow when they judged negatively-valenced faces, a slowness correlated with negative affect in the psychosis patients. Appraisal activated the medial prefrontal cortex (mPFC) across all face valences. For negative expressions, patients exhibited greater activation of the dorsal anterior cingulate cortex (dACC). A psychophysiological interaction analysis of the dACC revealed co-modulation of the mPFC in controls, significantly less in patients, and a trend for co-modulation of occipital cortex in the patients. Activity in occipital cortex correlated with poor social adjustment and impaired social cognition, and co-modulation of the occipital gyrus by the dACC was correlated with poorer social cognition. The findings link appraisal of negative affect with aberrant activation of the medial frontal cortex, while early sensory processing of this social cognitive task was linked with poor social function, reflecting either top-down or bottom-up influences.
authors.affiliation: Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Rd, Ann Arbor MI 48109-2700, USA. sftaylor@umich.edu
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Taylor
authors.forename: Ashley C
authors.initials: AC
authors.lastname: Chen
authors.forename: Ivy F
authors.initials: IF
authors.lastname: Tso
authors.forename: Israel
authors.initials: I
authors.lastname: Liberzon
authors.forename: Robert C
authors.initials: RC
authors.lastname: Welsh
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002908:Chronic Disease; D003072:Cognition Disorders / Q000209:etiology; D005145:Face; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D008875:Middle Aged; D009415:Nerve Net / Q000098:blood supply / Q000503:physiopathology; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D012944:Social Support
chemical_list: D010100:Oxygen
references.citation: Hum Brain Mapp. 2001 Apr;12(4):219-31
references.pmid: 11241873
references.citation: Schizophr Res. 2008 Jan;98(1-3):201-8
references.pmid: 17919890
references.citation: Am J Psychiatry. 1996 May;153(5):687-92
references.pmid: 8615416
references.citation: Biol Psychiatry. 2005 Jul 1;58(1):32-40
references.pmid: 15992520
references.citation: J Neurosci. 1998 Jun 15;18(12):4697-704
references.pmid: 9614244
references.citation: Psychiatry Res. 1998 Oct 19;81(1):57-65
references.pmid: 9829651
references.citation: Psychiatry Res. 2003 Feb 15;122(2):115-24
references.pmid: 12714175
references.citation: Clin Neurosci. 1995;3(2):89-97
references.pmid: 7583624
references.citation: Neuroimage. 2007 Aug 15;37(2):579-88
references.pmid: 17604651
references.citation: Nat Rev Neurosci. 2006 Apr;7(4):268-77
references.pmid: 16552413
references.citation: J Cogn Neurosci. 2002 Nov 15;14(8):1215-29
references.pmid: 12495527
references.citation: Hum Brain Mapp. 2009 Jul;30(7):2146-56
references.pmid: 18819107
references.citation: Schizophr Bull. 2010 Jul;36(4):713-22
references.pmid: 18990709
references.citation: Biol Psychiatry. 2007 May 15;61(10):1171-8
references.pmid: 17434455
references.citation: Neuroimage. 2002 Apr;15(4):870-8
references.pmid: 11906227
references.citation: J Cogn Neurosci. 2004 Dec;16(10):1746-72
references.pmid: 15701226
references.citation: Trends Cogn Sci. 2000 Jul;4(7):267-278
references.pmid: 10859571
references.citation: Brain Res Rev. 2008 Jun;58(1):57-70
references.pmid: 18076995
references.citation: Nat Neurosci. 2009 Apr;12(4):508-14
references.pmid: 19270690
references.citation: Neuroimage. 2005 Jun;26(2):374-88
references.pmid: 15907297
references.citation: Schizophr Bull. 2008 Jul;34(4):708-19
references.pmid: 18559406
references.citation: Psychiatry Res. 1994 Aug;53(2):141-51
references.pmid: 7824674
references.citation: Neuropsychopharmacology. 2005 May;30(5):984-95
references.pmid: 15689961
references.citation: Schizophr Res. 2005 Jul 15;76(2-3):287-92
references.pmid: 15949660
references.citation: Schizophr Res. 2001 Sep 1;51(2-3):171-80
references.pmid: 11518637
references.citation: Neuropsychologia. 2007 Jan 7;45(1):107-23
references.pmid: 16814818
references.citation: J Psychiatr Res. 2007 Dec;41(11):918-27
references.pmid: 17467008
references.citation: J Comp Neurol. 2005 Dec 5;493(1):154-66
references.pmid: 16254997
references.citation: Arch Gen Psychiatry. 2004 Jan;61(1):34-41
references.pmid: 14706942
references.citation: Arch Gen Psychiatry. 1995 Oct;52(10):805-18; discussion 819-20
references.pmid: 7575100
references.citation: Neuroimage. 2010 Jun;51(2):930-9
references.pmid: 20188190
references.citation: Am J Psychiatry. 2004 Jan;161(1):53-8
references.pmid: 14702250
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: Schizophr Res. 2007 Aug;94(1-3):253-63
references.pmid: 17583481
references.citation: Schizophr Res. 2008 Mar;100(1-3):191-205
references.pmid: 18234477
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15238-43
references.pmid: 12417766
references.citation: Schizophr Res. 2002 Dec 1;58(2-3):159-72
references.pmid: 12409155
references.citation: Neuroimage. 2007;36 Suppl 2:T142-54
references.pmid: 17499161
references.citation: Schizophr Res. 1998 Nov 30;34(3):133-42
references.pmid: 9850979
references.citation: Brain. 2007 Feb;130(Pt 2):417-30
references.pmid: 16984902
references.citation: Schizophr Bull. 2000;26(4):847-54
references.pmid: 11087017
references.citation: Neuroimage. 2003 Sep;20(1):84-97
references.pmid: 14527572
references.citation: Rev Neurosci. 2003;14(4):303-16
references.pmid: 14640318
references.citation: Neuroimage. 2004 Feb;21(2):768-80
references.pmid: 14980580
references.citation: Curr Opin Psychiatry. 2005 Mar;18(2):151-7
references.pmid: 16639168
references.citation: Nat Neurosci. 2006 Jul;9(7):940-7
references.pmid: 16783368
references.citation: Cerebellum. 2007;6(3):254-67
references.pmid: 17786822
references.citation: Schizophr Res. 2002 Sep 1;57(1):87-95
references.pmid: 12165379
references.citation: J Pers Soc Psychol. 1985 Apr;48(4):813-38
references.pmid: 3886875
references.citation: Neuroimage. 2003 Aug;19(4):1381-94
references.pmid: 12948696
references.citation: Biol Psychiatry. 2001 Aug 1;50(3):171-8
references.pmid: 11513815
references.citation: Science. 1992 Jan 24;255(5043):419-23
references.pmid: 1734518
references.citation: Neuroimage. 2004 Jul;22(3):1247-54
references.pmid: 15219596
references.citation: Neuroimage. 1997 Oct;6(3):218-29
references.pmid: 9344826
references.citation: Am J Psychiatry. 2005 Dec;162(12):2322-9
references.pmid: 16330597
references.citation: Schizophr Res. 2006 Apr;83(2-3):247-56
references.pmid: 16540291
references.citation: Biol Psychiatry. 2003 Feb 1;53(3):211-5
references.pmid: 12559653
references.citation: Schizophr Bull. 2008 Sep;34(5):856-74
references.pmid: 18667393
references.citation: J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
references.pmid: 14399272
references.citation: Psychol Sci. 2008 Feb;19(2):152-60
references.pmid: 18271863
references.citation: Am J Psychiatry. 2009 Feb;166(2):216-25
references.pmid: 19074979
references.citation: Neuroimage. 2002 Apr;15(4):983-91
references.pmid: 11906238
references.citation: Psychol Med. 2001 Aug;31(6):1065-78
references.pmid: 11513374
references.citation: J Abnorm Psychol. 2002 Feb;111(1):186-91
references.pmid: 11866172
references.citation: Schizophr Res. 2007 Feb;90(1-3):284-94
references.pmid: 17222539
references.citation: Brain. 2005 Nov;128(Pt 11):2597-611
references.pmid: 16183659
references.citation: Arch Gen Psychiatry. 2006 Nov;63(11):1180-8
references.pmid: 17088498
references.citation: Neuropsychopharmacology. 2009 Jan;34(2):477-87
references.pmid: 18580874
references.citation: Trends Cogn Sci. 2004 Mar;8(3):102-7
references.pmid: 15301749
references.citation: Neuroimage. 2002 Oct;17(2):825-41
references.pmid: 12377157
references.citation: Trends Cogn Sci. 2004 Dec;8(12):539-46
references.pmid: 15556023
references.citation: Neuroimage. 1995 Sep;2(3):173-81
references.pmid: 9343600
references.citation: Schizophr Res. 2005 Jun 15;75(2-3):363-74
references.pmid: 15885527
references.citation: Schizophr Res. 2006 Feb 28;82(2-3):153-62
references.pmid: 16377154
references.citation: Am J Psychiatry. 2003 Oct;160(10):1768-74
references.pmid: 14514489
references.citation: Biol Psychiatry. 2008 Jul 1;64(1):48-61
references.pmid: 18549876
references.citation: Neuroimage. 2006 May 1;30(4):1441-8
references.pmid: 16368249
references.citation: JAMA. 2001 Jul 25;286(4):427-35
references.pmid: 11466121
references.citation: Am J Psychiatry. 2006 Mar;163(3):448-54
references.pmid: 16513866
references.citation: Arch Gen Psychiatry. 1994 Dec;51(12):945-51
references.pmid: 7979882
references.citation: Schizophr Res. 2010 Sep;122(1-3):156-63
references.pmid: 20051314
references.citation: Schizophr Res. 2008 Feb;99(1-3):164-75
references.pmid: 18053686
references.citation: Neuroimage. 2003 May;19(1):200-7
references.pmid: 12781739
references.citation: Schizophr Bull. 2007 Sep;33(5):1171-7
references.pmid: 17105966
references.citation: Schizophr Bull. 2010 Jan;36(1):143-50
references.pmid: 18562345
references.citation: Schizophr Bull. 1998;24(3):413-24
references.pmid: 9718633
references.citation: Cerebellum. 2005;4(4):290-4
references.pmid: 16321885
references.citation: Neuroimage. 1999 Mar;9(3):337-42
references.pmid: 10075903
references.citation: Psychol Sci. 2006 Jul;17(7):592-8
references.pmid: 16866745
references.citation: Neuropsychopharmacology. 2004 Jan;29(1):171-8
references.pmid: 14520337
references.citation: Am J Psychiatry. 2006 Nov;163(11):1926-33
references.pmid: 17074944
references.citation: Neuroimage. 2002 Jun;16(2):331-48
references.pmid: 12030820
references.citation: J Pers Soc Psychol. 2003 Feb;84(2):365-76
references.pmid: 12585810
references.citation: Schizophr Res. 2003 Feb 1;59(2-3):233-41
references.pmid: 12414080
references.citation: Am J Psychiatry. 1993 Sep;150(9):1325-36
references.pmid: 8352343
references.citation: Neurophysiol Clin. 2007 Apr-May;37(2):77-87
references.pmid: 17540290
references.citation: Am J Psychiatry. 2007 May;164(5):813-9
references.pmid: 17475741
references.citation: Nat Rev Neurosci. 2002 Jul;3(7):563-73
references.pmid: 12094212
references.citation: Am J Psychiatry. 2002 Dec;159(12):1992-9
references.pmid: 12450947
references.citation: Magn Reson Med. 2002 Aug;48(2):278-89
references.pmid: 12210936
references.citation: Neuropsychologia. 2007 Jan 7;45(1):174-94
references.pmid: 16854439
references.citation: Am J Psychiatry. 2004 Mar;161(3):480-9
references.pmid: 14992974
references.citation: Neuropsychologia. 2007 Jan 7;45(1):32-41
references.pmid: 16797608
references.citation: Science. 1999 Nov 26;286(5445):1692-5
references.pmid: 10576727
references.citation: Neuropsychologia. 2008;46(8):2129-39
references.pmid: 18440572
references.citation: Am J Psychiatry. 2003 Oct;160(10):1775-83
references.pmid: 14514490
references.citation: J Nerv Ment Dis. 1996 Sep;184(9):535-41
references.pmid: 8831643