title: Flipping the switch on chloride concentrations with a light-active foldamer.
abstract: Here we demonstrate a bioinspired system where light stimulus is used to trigger the wavelength-dependent release and then reuptake of chloride ions in nonaqueous solutions. A chiral aryl-triazole foldamer with two azobenzene end groups has been synthesized to define a folded binding pocket for chloride ions that unfolds with UV light to liberate the chloride. The trans-dominated helical foldamer becomes less stable upon photoisomerization to the cis forms. Simultaneously, the observed binding affinity shows an ∼10-fold reduction from K = 3000 M(-1) (MeCN, 298 K). Control of chloride levels using light is demonstrated by switching the conductivity of an electrolyte solution up and down.
authors.affiliation: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA.
authors.forename: Yuran
authors.initials: Y
authors.lastname: Hua
authors.forename: Amar H
authors.initials: AH
authors.lastname: Flood
mesh_terms: D032701:Biomimetics; D002712:Chlorides / Q000737:chemistry*; D008027:Light; D008958:Models, Molecular; D008968:Molecular Conformation / Q000528:radiation effects*; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D002712:Chlorides; D011108:Polymers; D012997:Solvents