Echocardiographic imaging of tricuspid and pulmonary valve abnormalities in primary ovarian carcinoid tumor.
Carcinoid is a rare malignancy originating from enterochromaffin cells and is clinically characterized by flushing, diarrhea and bronchospasm, due to secretion of vasoactive substances. A dreaded complication is carcinoid heart disease, which mainly affects right cardiac chambers, resulting in thickened, immobile and retracted tricuspid and pulmonary valves. In the current report, a case of a 60-year old female presenting with symptoms of right heart failure is described. Transthoracic two-dimensional and real-time three-dimensional echocardiography findings, as well as biochemical markers, including pro-BNP and NT-pro-BNP, were consistent with carcinoid syndrome. The histological diagnosis of carcinoid was confirmed after surgical resection of an ovarian mass.
Aggeli
Constantina
C
1st Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece. caggeli@otenet.gr
Felekos
Ioannis
I
Kazazaki
Christina
C
Giannopoulos
Dimitrios
D
Kartalis
Athanasios
A
Pitsavos
Christos
C
Stefanadis
Christodoulos
C
D002276:Carcinoid Tumor / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D011664:Pulmonary Valve; D014261:Tricuspid Valve; D014741:Video Recording
Circulation. 2007 Dec 11;116(24):2860-5
18071089
Heart. 2004 Oct;90(10):1224-8
15367531
Eur Radiol. 2003 Dec;13 Suppl 6:L14-8
16440219
Am J Cardiol. 2008 Feb 1;101(3):378-81
18237604
Am J Cardiol. 2010 Jun 1;105(11):1588-91
20494667
Circ Cardiovasc Imaging. 2010 Jan;3(1):103-11
19920029
Eur J Gynaecol Oncol. 2008;29(5):554-5
19051836
Circulation. 2005 Nov 22;112(21):3320-7
16286584
Curr Cardiol Rep. 2006 Mar;8(2):96-101
16524535
Circulation. 1995 Aug 15;92(4):790-5
7641358
Am J Cardiol. 2004 May 15;93(10):1314-5
15135715
Clin Radiol. 2009 Aug;64(8):761-6
19589414
Clin Cardiol. 2009 Jun;32(6):E92-3
19382278
J Am Soc Echocardiogr. 2008 Apr;21(4):407.e1-2
17904800
Cancer. 2003 Feb 15;97(4):934-59
12569593