Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts.
Bovine lactoferrin (BLF) enhanced production of hyaluronan in normal human dermal fibroblasts. The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. The promoting effect of BLF was not observed for HAS1. In addition, COL1A1 transcription and collagen synthesis were enhanced by BLF. These observations suggest that BLF promotes wound healing by increasing hyaluronan and type-I collagen synthesis.
Saito
Shinichi
S
Functional Biomolecules Research Team, National Institute of Livestock and Grassland Science, 2 Ikenodai, Tsukuba, Ibaraki, 305-0901, Japan.
Takayama
Yoshiharu
Y
Mizumachi
Koko
K
Suzuki
Chise
C
D000818:Animals; D002417:Cattle; D024042:Collagen Type I / Q000096:biosynthesis; D000090602:Collagen Type I, alpha 1 Chain; D005347:Fibroblasts / Q000378:metabolism*; D015870:Gene Expression; D014453:Glucuronosyltransferase / Q000096:biosynthesis; D006801:Humans; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000096:biosynthesis*; D007781:Lactoferrin / Q000378:metabolism*; D015854:Up-Regulation; D014945:Wound Healing
D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; C101754:HAS2 protein, human; D000076002:Hyaluronan Synthases; D007781:Lactoferrin