The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats.
The effects of Cordyceps sinensis (Caterpillar fungus) and strontium ranelate on ovariectomized osteopenic rats was studied in this paper. After the rats were treated orally with C. sinensis, strontium, and C. sinensis rich in strontium ranelate (CSS) respectively, serum alkaline phosphatase (ALP), tartarate-resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine, C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol, and interferon-gamma (IFN-γ) level were examined. The beneficial effects of CSS on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level, and IFN-γ level. At the same time, CSS also increase the OC and estradiol level in ovariectomized osteopenic rats. This study demonstrates the value of C. sinensis rich in strontium ranelate in the management of postmenopausal osteoporosis in humans.
Qi
Wei
W
Department of orthpedics, Xijing hospital, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
Wang
Pu-jie
PJ
Guo
Wen-jun
WJ
Yan
Ya-bo
YB
Zhang
Yang
Y
Lei
Wei
W
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D024042:Collagen Type I / Q000378:metabolism; D032661:Cordyceps / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism; D007527:Isoenzymes / Q000097:blood; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000378:metabolism; D010024:Osteoporosis / Q000097:blood / Q000517:prevention & control*; D051381:Rats; D013324:Strontium / Q000008:administration & dosage / Q000378:metabolism*; D000071681:Tartrate-Resistant Acid Phosphatase; D013876:Thiophenes / Q000008:administration & dosage / Q000378:metabolism
D024042:Collagen Type I; D007527:Isoenzymes; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D007371:Interferon-gamma; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D013324:Strontium