title: Increased transcutaneous oxygen pressure is an indicator of revascularization after peripheral transluminal angioplasty.
abstract: BACKGROUND
  In recent years, the use of peripheral transluminal angioplasty (PTA) procedures for revascularization of an ischemic limb has increased. Evaluation of reperfusion has been carried out by Doppler scan; however, a successful PTA does not necessarily result in improved oxygen delivery to the distal parts of the limb.
  
  
  OBJECTIVE
  To evaluate the efficacy of the revascularization in diabetic patients with critical limb ischemia after treatment with PTA by comparing transcutaneous oxygen tension (TcpO₂) with the ankle-brachial index (ABI) post PTA.
  
  
  METHODS
  This prospective study included 151 consecutive diabetic patients. We evaluated the posterior tibial and dorsalis pedis Doppler, ABI, TcpO₂, and duplex scan results. If two of these four examinations were abnormal, arteriography was carried out and PTA was performed concomitantly. At least 64 patients were considered suitable candidates for PTA.
  
  
  RESULTS
  The ABI increased from 0.67±0.25 to 0.84±0.25 following PTA (P<0.001). TcpO₂ increased from 27.20±11.10 mm Hg to 40±12.10 mm Hg after PTA (P<0.001). While the TcpO₂ could be measured in all patients, the ABI was not measurable in 25.37% pretreatment and in 17.91% post treatment. Statistical analysis revealed a scant correlation between the techniques used: TcpO₂ and ABI (P=0.20).
  
  
  CONCLUSIONS
  Our study confirms that the increase in TcpO₂ in diabetic patients following PTA points to the physiologic significance of microvascular revascularization achieved in the treated limb and serves to assess functional improvement in tissue oxygenation obtained by PTA. The use of TcpO₂ may represent an alternative to traditional assessment of peripheral transluminal angioplasty results.
authors.affiliation: Department of Radiology and Physical Medicine, Faculty of Medicine/Dentistry, University of Murcia, Espinardo, Murcia, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Pardo
authors.forename: Miguel
authors.initials: M
authors.lastname: Alcaraz
authors.forename: Francisco
authors.initials: F
authors.lastname: Ramón Breijo
authors.forename: Fernando Luis
authors.initials: FL
authors.lastname: Bernal
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Felices
authors.forename: Manuel
authors.initials: M
authors.lastname: Canteras
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D017130:Angioplasty / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D001785:Blood Gas Monitoring, Transcutaneous; D017719:Diabetic Foot / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D011312:Pressure; D011446:Prospective Studies; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D010100:Oxygen