title: Evaluation of selected rheumatoid arthritis activity scores for office-based assessment.
abstract: OBJECTIVE
  Patient-reported measures can quickly provide assessments of rheumatoid arthritis (RA) disease activity in the office setting and do not require a laboratory test or physician examination. The goal of our study was to establish the validity of patient-reported indices compared to the C-reactive protein-based Disease Activity Score (DAS28-CRP4).
  
  
  METHODS
  Baseline and 1-year followup DAS28-CRP4 data were obtained from 740 RA subjects and were compared to indices (MDHAQ, CDAI, RAPID, RADAI, GAS) according to cyclic citrullinated peptide (CCP) status and change at 1 year. Pairwise correlations were calculated for each index.
  
  
  RESULTS
  Among 740 subjects, mean age 57 years, disease duration 14 years, the CDAI (r = 0.84, Δ r = 0.80) and RAPID (r = 0.71, Δ r = 0.70) had the highest correlation with the DAS28-CRP4 scores at baseline and 1 year. These correlations were not influenced by CCP status, disease-modifying antirheumatic drug use, biologic use, or by disease duration.
  
  
  CONCLUSIONS
  In RA, the CDAI and RAPID correlated well with the DAS28-CRP4. They may both be practical and informative in the care of patients in the office setting.
authors.affiliation: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Sullivan
authors.forename: Christine
authors.initials: C
authors.lastname: Iannaccone
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Bing
authors.initials: B
authors.lastname: Lu
authors.forename: Kerri
authors.initials: K
authors.lastname: Batra
authors.forename: Michael
authors.initials: M
authors.lastname: Weinblatt
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Shadick
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000473:pathology* / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009819:Office Visits; D010456:Peptides, Cyclic / Q000097:blood; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D010456:Peptides, Cyclic; D002097:C-Reactive Protein