title: Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus.
abstract: BACKGROUND
  Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long-term follow-up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously.
  
  
  OBJECTIVE
  To evaluate the long-term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
  
  
  METHODS
  Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow-up 15 months). Long-term results were evaluated by 54 patients using a questionnaire up to 7·7 years after treatment (mean 4 years).
  
  
  RESULTS
  More than 75% repigmentation was achieved in 71% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post-treatment. In 80% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0·012). During follow-up 7% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation.
  
  
  CONCLUSIONS
  Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow-up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained.
authors.affiliation: Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Nanja.vangeel@UGent.be
authors.forename: N
authors.initials: N
authors.lastname: van Geel
authors.forename: E
authors.initials: E
authors.lastname: Wallaeys
authors.forename: B K
authors.initials: BK
authors.lastname: Goh
authors.forename: M
authors.initials: M
authors.lastname: De Mil
authors.forename: J
authors.initials: J
authors.lastname: Lambert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017690:Cell Transplantation / Q000379:methods*; D002648:Child; D000078404:Epidermal Cells; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000473:pathology / Q000601:surgery*; D017060:Patient Satisfaction; D016116:Piebaldism / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D012880:Skin Pigmentation; D011795:Surveys and Questionnaires; D014182:Transplantation, Autologous; D014820:Vitiligo / Q000473:pathology / Q000601:surgery*; D055815:Young Adult