title: Nonalcoholic steatohepatitis and increased risk of chronic kidney disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common features. Both are associated with visceral obesity, type 2 diabetes mellitus, metabolic syndrome, and insulin resistance. However, the relationship between NAFLD and CKD is poorly understood. We examined the prevalence of and risk factors for CKD in patients with NAFLD. We analyzed 174 Japanese patients with liver biopsy-proven NAFLD using a cross-sectional design. Chronic kidney disease was defined as estimated glomerular filtration rate less than 60 mL/min per 1.73 m(2) and/or overt proteinuria. Of 174 NAFLD patients, 92 (53%) exhibited histologic characteristics of nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD; and 82 (47%) had non-NASH NAFLD. Chronic kidney disease was present in 24 (14%) of 174 NAFLD patients. The prevalence of CKD was significantly higher in NASH patients (19 of 92; 21%) than non-NASH patients (5 of 82; 6%). The presence of CKD was associated with a higher body mass index and the presence of hypertension and NASH. Our results demonstrated a high prevalence of CKD among patients with NASH.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan. yasuik@koto.kpu-m.ac.jp
authors.forename: Kohichiroh
authors.initials: K
authors.lastname: Yasui
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sumida
authors.forename: Yasukiyo
authors.initials: Y
authors.lastname: Mori
authors.forename: Hironori
authors.initials: H
authors.lastname: Mitsuyoshi
authors.forename: Masahito
authors.initials: M
authors.lastname: Minami
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Itoh
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kanemasa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsubara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okanoue
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D015992:Body Mass Index; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000150:complications / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D007674:Kidney Diseases / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D011507:Proteinuria / Q000453:epidemiology; D012307:Risk Factors; D055815:Young Adult