title: Single nucleotide polymorphisms in the phospholipase A2 receptor gene are associated with genetic susceptibility to idiopathic membranous nephropathy.
abstract: BACKGROUND
  The phospholipase A(2) receptor (PLA2R) is a major antigen found in patients with idiopathic membranous nephropathy (MN). The relationship of genetic polymorphisms of PLA2R with the susceptibility and clinical outcomes of this disease is unknown.
  
  
  METHODS
  We studied 199 patients with idiopathic MN followed up for 3.7 ± 3.2 years. We enrolled 33 patients with secondary MN and 356 subjects with normal blood pressure and no proteinuria. PLA2R single nucleotide polymorphisms (SNPs) were genotyped.
  
  
  RESULTS
  The allele frequencies of C in rs35771982 and G in rs3828323 were 73.6 and 73.9%, respectively. Subjects with the CC genotype in rs35771982 had a higher susceptibility to idiopathic MN compared to subjects with other genotypes (odds ratio 2.6; 95% confidence interval 1.8-4.0). Patients with secondary MN were not different from controls with regard to PLA2R genotype. No impact of genetic polymorphisms on renal survival was detected.
  
  
  CONCLUSIONS
  The findings of this study suggest that PLA2R SNPs might be associated with the risk of developing MN.
authors.affiliation: Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: Sejoong
authors.initials: S
authors.lastname: Kim
authors.forename: Ho Jun
authors.initials: HJ
authors.lastname: Chin
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Na
authors.forename: Suhnggwon
authors.initials: S
authors.lastname: Kim
authors.forename: Jieun
authors.initials: J
authors.lastname: Oh
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Noh
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Lee
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Cho
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Lee
authors.forename: Dong-Wan
authors.initials: DW
authors.lastname: Chae
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054507:Receptors, Phospholipase A2 / Q000235:genetics*
chemical_list: D054507:Receptors, Phospholipase A2