title: Neuroendocrine tumors of Meckel's diverticulum: lessons from a single institution study of eight cases.
abstract: BACKGROUND
  Endocrine tumors of Meckel's diverticulum are rare. Their clinical and pathological characteristics are not well known, making it difficult to assess the best strategy for therapeutic management.
  
  
  METHODS
  Eight cases of endocrine tumors of Meckel's diverticulum, submitted to surgical resection in our institution between 1977 and 2009, were studied. Clinical charts were reviewed; classification, grading, and staging were performed according to recent international recommendations. Five cases, including two associated with the carcinoid syndrome, were revealed by mesenteric mass or liver metastases; three cases were diagnosed incidentally at laparotomy or laparoscopy.
  
  
  RESULTS
  All cases presented as typical well-differentiated midgut endocrine tumors. Five cases were associated with mesenteric lymph node metastases; three presented with liver metastases. Seven cases were classified as well-differentiated endocrine carcinomas, one as well-differentiated endocrine tumor of benign behavior.
  
  
  CONCLUSIONS
  All tumors >1 cm, but one, had regional or distant disease. All patients had complete surgical resection of the primary. One patient deceased after 25 months; the others were alive after 12-101 months.
  
  
  CONCLUSIONS
  In conclusion, endocrine tumors of Meckel's diverticulum are rarely symptomatic and often diagnosed at an advanced stage. All tumors measuring more than 1 cm in diameter must be resected according to oncological principles.
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Fédération des Spécialités Digestives, Lyon, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Poncet
authors.forename: Valérie
authors.initials: V
authors.lastname: Hervieu
authors.forename: Thomas
authors.initials: T
authors.lastname: Walter
authors.forename: Florian
authors.initials: F
authors.lastname: Lépinasse
authors.forename: Laurence
authors.initials: L
authors.lastname: Chardon
authors.forename: Frank
authors.initials: F
authors.lastname: Pilleul
authors.forename: Catherine
authors.initials: C
authors.lastname: Lombard-Bohas
authors.forename: Jean-Alain
authors.initials: JA
authors.lastname: Chayvialle
authors.forename: Christian
authors.initials: C
authors.lastname: Partensky
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D010535:Laparoscopy; D007813:Laparotomy; D008297:Male; D008467:Meckel Diverticulum / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D011379:Prognosis
references.citation: Pathology. 2006 Oct;38(5):452-4
references.pmid: 17008288
references.citation: J Am Osteopath Assoc. 2000 Jul;100(7):432-4
references.pmid: 10943090
references.citation: Neuroendocrinology. 2008;87(1):8-19
references.pmid: 18097129
references.citation: Chir Ital. 2004 Sep-Oct;56(5):689-92
references.pmid: 15553441
references.citation: World J Surg. 2005 Jan;29(1):92-101
references.pmid: 15599742
references.citation: World J Gastroenterol. 2010 Apr 14;16(14):1696-706
references.pmid: 20380000
references.citation: Ugeskr Laeger. 1987 Sep 14;149(38):2538
references.pmid: 3451474
references.citation: Int Surg. 2003 Jan-Mar;88(1):41-6
references.pmid: 12731730
references.citation: Neuroendocrinology. 2008;87(1):20-30
references.pmid: 17934252
references.citation: J Clin Gastroenterol. 1989 Dec;11(6):682-6
references.pmid: 2685098
references.citation: Dis Colon Rectum. 1992 Jun;35(6):589-96
references.pmid: 1587179
references.citation: Am J Med. 1987 Jul;83(1):184-6
references.pmid: 3605172
references.citation: JSLS. 2008 Jan-Mar;12(1):66-70
references.pmid: 18402742
references.citation: Histopathology. 2003 Dec;43(6):608-9
references.pmid: 14636264
references.citation: Minerva Chir. 1990 Aug;45(15-16):1043-7
references.pmid: 2280858
references.citation: World J Gastroenterol. 2008 Aug 21;14(31):4961-3
references.pmid: 18756607
references.citation: Acta Chir Belg. 2006 Jul-Aug;106(4):467-70
references.pmid: 17017710
references.citation: Am J Clin Pathol. 2005 Mar;123(3):394-404
references.pmid: 15716236
references.citation: Arch Pathol Lab Med. 2006 Oct;130(10):1522-6
references.pmid: 17090195
references.citation: Virchows Arch. 2006 Oct;449(4):395-401
references.pmid: 16967267
references.citation: Am J Clin Pathol. 1989 Jan;91(1):52-6
references.pmid: 2462784
references.citation: J Pathol. 1986 Feb;148(2):141-7
references.pmid: 3512805
references.citation: South Med J. 2004 Nov;97(11):1038-41
references.pmid: 15586591
references.citation: Am Surg. 1988 Nov;54(11):664-7
references.pmid: 3056140
references.citation: Virchows Arch. 2004 Sep;445(3):248-54
references.pmid: 15517368
references.citation: Aust N Z J Surg. 1993 Sep;63(9):732-4
references.pmid: 8363487
references.citation: Virchows Arch. 2007 Oct;451(4):757-62
references.pmid: 17674042
references.citation: Curr Surg. 2003 May-Jun;60(3):301-3
references.pmid: 14972261