t10,c12-18:2-induced milk fat depression is less pronounced in cows fed high-concentrate diets.
In intensively reared dairy cows, milk fat secretion is reduced in response to high-concentrate diets and it is often referred to as the "milk fat depression" (MFD) syndrome. Some trans fatty acid (FA) isomers produced in the rumen of the cows, including t10,c12-18:2, are known for their inhibitory effect on mammary lipogenesis. To study whether this effect depends on the basal diet, duodenal infusions of t10,c12-18:2 were performed on cows fed four different diets (a factorial arrangement of forage:concentrate ratio and linseed oil supplementation). The overall response obtained with t10,c12-18:2 infusion was consistent with previous studies: a decrease in milk fat content and yield without significant variations in milk yield. Mean transfer efficiency of infused t10,c12-18:2 was 19.6%. However, the decrease in milk fat and FA yields (both de novo synthesis and preformed long-chain FA) was less pronounced in cows fed high-concentrate diets (-27% of the initial level), compared with cows fed low-concentrate diets (-42% of initial level). This difference was independent of dietary oil supplementation and milk FA yield before infusion. Results pertaining to effects of dietary forage:concentrate ratio were confirmed by statistical meta-analysis of data from previously published t10,c12-18:2 infusion experiments. This study shows that in cows fed MFD diets the mammary gland becomes more resistant to or experiences a lower response potential to further inhibition of lipogenesis and/or delta-9 desaturation of FA.
Glasser
Frédéric
F
INRA, UR1213 Herbivores, Site de Theix, 63122, Saint-Genès-Champanelle, France.
Ferlay
Anne
A
Doreau
Michel
M
Loor
Juan J
JJ
Chilliard
Yves
Y
D000821:Animal Feed; D000818:Animals; D002417:Cattle; D005227:Fatty Acids / Q000032:analysis*; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology*; D008043:Linseed Oil / Q000008:administration & dosage; D008892:Milk / Q000737:chemistry*
D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated; C496197:trans-10,cis-12-conjugated linoleic acid; D008043:Linseed Oil
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