Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice.
Taurine, a sulfur-containing beta-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardiac and skeletal muscles. Meanwhile, taurine deficiency leads various pathologies, including dilated cardiomyopathy, in cat and fox. However, the essential role of taurine depletion on pathogenesis has not been fully clarified. To address the physiological role of taurine in mammalian tissues, taurine transporter-(TauT-) knockout models were recently generated. TauTKO mice exhibited loss of body weight, abnormal cardiac function and the reduced exercise capacity with tissue taurine depletion. In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice.
Ito
Takashi
T
Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan.
Oishi
Shohei
S
Takai
Mika
M
Kimura
Yasushi
Y
Uozumi
Yoriko
Y
Fujio
Yasushi
Y
Schaffer
Stephen W
SW
Azuma
Junichi
J
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D010805:Physical Conditioning, Animal; D013654:Taurine / Q000172:deficiency; D000099247:Taurine Transporters
D015415:Biomarkers; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D013654:Taurine; D000099247:Taurine Transporters
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