title: [ESBL-producing enterobacteria in Passo Fundo, state of Rio Grande do Sul, Brazil].
abstract: BACKGROUND
  The main emerging resistance mechanism relating to Enterobacteriaceae is represented by production of extended spectrum beta-lactamases (ESBLs). These enzymes have the capacity to hydrolyze broad-spectrum cephalosporins and are greatly used for antimicrobial chemotherapy on enterobacterial infections. Although resistance to these agents presents remarkable geographical variability, the resistance rates are high in many countries
  
  
  METHODS
  A retrospective observational cross-sectional descriptive study was developed to evaluate the frequency of ESBLs among Enterobacteriaceae strains obtained from Hospital São Vicente de Paulo, Brazil
  
  
  RESULTS
  ESBL production was noted in 24.8% (n = 208/838) of the isolates evaluated. Isolates of Escherichia coli represented 46.2% (n = 96/208) of the ESBL producers, followed by Enterobacter species (30.3%; n = 63/208). The sensitivity of these isolates to meropenem was 91.4% and to piperacillin/tazobactam, 67.4%
  
  
  CONCLUSIONS
  The ESBL levels founded confirm the worldwide concern regarding this resistance mechanism.
authors.affiliation: Curso de Ciências Biológicas, Universidade de Passo Fundo, Passo Fundo, RS.
authors.forename: Aldalise
authors.initials: A
authors.lastname: Lago
authors.forename: Sergio Roberto
authors.initials: SR
authors.lastname: Fuentefria
authors.forename: Daiane Bopp
authors.initials: DB
authors.lastname: Fuentefria
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001938:Brazil; D003430:Cross-Sectional Studies; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D005260:Female; D006769:Hospitals, General / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases