Whole-genomic survey of oligodendroglial tumors: correlation between allelic imbalances and gene expression profiles.
Malignant gliomas are the most common subtype of primary central nervous system (CNS) tumors. Their pathological classification, however, remains subjective, stimulating researchers to actively seek objective molecular markers to discover alternative and more reproducible tools for improved subtypification. Herein, we present a global survey of genomic alterations in oligodendroglial tumors (OT). Genetic and epigenetic alterations identified in this study are correlated with OT molecular groups we have recently reported: a neurogenic group composed of tumors with loss of heterozygosity (LOH) at 1p-19q, IDH1 mutations, and MGMT promoter methylation, showing good prognosis; an intermediate group, presenting TP53 mutations or LOH at 17p, IDH1 mutations, and GSTP1 promoter methylation; and a proliferative group, presenting major genetic alterations (LOH at 10q, EGFR amplification, and CDKN2A/ARF deletion) and poor prognosis. These results allowed us to refine our molecular characterization associated with prognosis, referring exclusively to oligodendroglial tumors.
Ferrer-Luna
Rubén
R
Department of Physical-Chemistry, Universitat de Valencia, Dr. Moliner sn, 46100 Burjassot, Valencia, Spain.
Núñez
Lina
L
Piquer
José
J
Arias
Eugenia
E
Dasí
Francisco
F
Cervio
Andrés
A
Arakaki
Naomi
N
Sevlever
Gustavo
G
Celda
Bernardo
B
Martinetto
Horacio
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D022981:Allelic Imbalance; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000235:genetics*; D002675:Child, Preschool; D002877:Chromosomes, Human / Q000235:genetics; D019175:DNA Methylation; D057890:Epigenomics; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009837:Oligodendroglioma / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D015996:Survival Rate
D014408:Biomarkers, Tumor; D012333:RNA, Messenger
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