Serum uric acid predicts changes in reports of non-gouty chronic pain: a prospective study among women with inflammatory and non-inflammatory pain.
Widespread pain has earlier been associated with an increase in serum urate (SU). The aim of this study was to longitudinally study the relation between changes in pain reporting and the level of SU among women with chronic pain. Consecutive female patients (n = 124; aged 20-70 years), at rheumatology and rehabilitation practices, with chronic musculoskeletal pain of different origins were followed for 1 year with repeated blood samples and questionnaires. Complete data were obtained from 107 individuals. Factors that predicted an increase in pain extension during 12 months were studied in a logistic regression model. Changes in SU showed a significant correlation (r = 0.36) with changes in the number of reported pain locations. An initially high SU level (OR = 4.46), frequent use of alcohol (OR = 1.32) and a high number of pain locations (OR = 1.24) independently predicted an increase in pain extension during 12 months, whereas the use of steroids (OR = 0.21) in patients with inflammatory disorders resulted in a decreased number of reported pain locations. A relative increase in SU in combination with report of a high number of pain locations turned out to be a risk factor of increased pain extension in a cohort of women with chronic non-gouty pain followed during 1 year. The importance of SU in relation to chronic pain and its prognosis needs to be validated in larger studies.
Andersson
H Ingemar
HI
School of Health and Society, Kristianstad University, Kristianstad, Sweden. ingemar.andersson@hkr.se
Leden
Ido
I
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D059350:Chronic Pain / Q000097:blood* / Q000175:diagnosis*; D015331:Cohort Studies; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008875:Middle Aged; D059352:Musculoskeletal Pain / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid
Rheumatol Int. 2006 May;26(7):585-97
16328420
Eur J Pain. 2008 Aug;12(6):742-8
18160318
Free Radic Biol Med. 1993 Jun;14(6):615-31
8325534
Eur J Pain. 2004 Feb;8(1):47-53
14690674
Am J Hypertens. 2006 Oct;19(10):1055-62
17027827
Scand J Rheumatol. 1994;23(1):25-9
8108664
Neurology. 2005 Aug 9;65(3):437-43
16087910
Rheumatology (Oxford). 2008 Aug;47(8):1235-8
18550637
Disabil Rehabil. 2009;31(24):1980-7
19874076
Pain. 2009 Jan;141(1-2):25-30
18977088
J Rheumatol. 2002 Apr;29(4):818-25
11950027
Scand J Rheumatol. 1996;25(3):146-54
8668957
Eur Spine J. 2008 Mar;17(3):393-405
18075764
Rheumatology (Oxford). 2009 Jan;48(1):74-7
19056799
Neurosci Biobehav Rev. 1999;23(6):877-90
10541062
BMJ. 2001 Sep 22;323(7314):662-5
11566829
Clin Sci (Lond). 2003 Oct;105(4):425-30
12801243
Clin Rheumatol. 2008 Apr;27(4):483-9
17874170
Ann Rheum Dis. 2002 Dec;61(12):1071-4
12429537
Arch Intern Med. 2004 Jul 26;164(14):1546-51
15277287
Scand J Rheumatol. 1992;21(6):277-82
1475637
J Rheumatol. 2005 Jul;32(7):1341-8
15996075
Scand J Rheumatol. 2006 Jul-Aug;35(4):261-7
16882588
Arthritis Rheum. 2009 Feb 15;61(2):225-32
19177541
Ann Epidemiol. 2004 Aug;14(7):467-72
15301783