title: Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: a single-center experience.
abstract: BACKGROUND
  Pre-operative infection with organisms from the Burkholderia cepacia complex (BCC), particularly B cenocepacia, has been linked with a poorer prognosis after transplantation compared to patients with cystic fibrosis (CF) without this infection. Therefore, many transplant centers do not list these patients for transplantation.
  
  
  METHODS
  We report the early and long-term results of a cohort of lung transplant recipients with CF and pre-operative BCC infection. Patients with pre-transplantation BCC infection were identified by case-note review. BCC species status was assigned by polymerase chain reaction (PCR)-based techniques. Survival rates were compared to recipients with CF without BCC infection. Survival rates in BCC subgroups were also compared, and then further analyzed pre- and post-2001, when a new immunosuppressive and antibiotic regime was introduced for such patients.
  
  
  RESULTS
  Two hundred sixteen patients with CF underwent lung transplantation and 22 had confirmed pre-operative BCC infection, with 12 of these being B cenocepacia. Nine B cenocepacia-infected recipients died within the first year, and in 8 BCC sepsis was considered to be the cause of death. Despite instituting a tailored peri-operative immunosuppressive and microbiologic care approach for such patients, post-transplantation BCC septic deaths occurred frequently in those with pre-transplantation B cenocepacia infection. In contrast, recipients infected with other BCC species had significantly better outcomes, with post-transplantation survival comparable to other recipients with CF.
  
  
  CONCLUSIONS
  Mortality in patients with B cenocepacia infection was unacceptably high and has led to our center no longer accepting patients with this condition onto the lung transplant waiting list. Long-term survival in the non-B cenocepacia BCC group was excellent, without high rates of acute rejection or bronchiolitis obliterans syndrome (BOS) longer term, and these patients continue to be considered for lung transplantation.
authors.affiliation: Transplantation and Immunobiology Group, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK. anthony.de-soyza@ncl.ac.uk
authors.forename: Anthony
authors.initials: A
authors.lastname: De Soyza
authors.forename: Gerard
authors.initials: G
authors.lastname: Meachery
authors.forename: Katy L M
authors.initials: KL
authors.lastname: Hester
authors.forename: Audrey
authors.initials: A
authors.lastname: Nicholson
authors.forename: Gareth
authors.initials: G
authors.lastname: Parry
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Tocewicz
authors.forename: Thasee
authors.initials: T
authors.lastname: Pillay
authors.forename: Stephen
authors.initials: S
authors.lastname: Clark
authors.forename: James L
authors.initials: JL
authors.lastname: Lordan
authors.forename: Stephan
authors.initials: S
authors.lastname: Schueler
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Fisher
authors.forename: John H
authors.initials: JH
authors.lastname: Dark
authors.forename: F Kate
authors.initials: FK
authors.lastname: Gould
authors.forename: Paul A
authors.initials: PA
authors.lastname: Corris
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019121:Burkholderia Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D057508:Burkholderia cenocepacia / Q000187:drug effects / Q000302:isolation & purification; D042602:Burkholderia cepacia complex / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D002423:Cause of Death; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000382:microbiology / Q000401:mortality* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality*; D012189:Retrospective Studies; D018805:Sepsis / Q000401:mortality; D013045:Species Specificity; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents