title: SnoN in mammalian development, function and diseases.
abstract: SnoN (Ski-novel protein) was discovered as a nuclear proto-oncogene on the basis of its ability to induce transformation of chicken and quail embryonic fibroblasts. As a crucial negative regulator of transforming growth factor-β (TGF-β) signaling and also an activator of p53, it plays an important role in regulating cell proliferation, senescence, apoptosis, and differentiation. Recent studies of its expression patterns and functions in mouse models and mammalian cells have revealed important functions of SnoN in normal epithelial development and tumorigenesis. Evidence suggests that SnoN has both pro-oncogenic and anti-oncogenic functions by modulating multiple signaling pathways. These studies suggest that SnoN may have broad functions in the development and homeostasis of embryonic and postnatal tissues.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, USA.
authors.forename: Nadine S
authors.initials: NS
authors.lastname: Jahchan
authors.forename: Kunxin
authors.initials: K
authors.lastname: Luo
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D047108:Embryonic Development; D005260:Female; D005786:Gene Expression Regulation; D016158:Genes, p53; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D058990:Molecular Targeted Therapy; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D011519:Proto-Oncogenes; D015398:Signal Transduction / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C060615:SKIL protein, human; D015534:Trans-Activators; D016212:Transforming Growth Factor beta
references.citation: J Biol Chem. 2007 Mar 2;282(9):6517-24
references.pmid: 17202138
references.citation: J Biol Chem. 2007 Mar 30;282(13):9475-9481
references.pmid: 17276978
references.citation: Oncogene. 1993 Feb;8(2):457-66
references.pmid: 8426750
references.citation: Cancer Res. 2005 Mar 15;65(6):2296-302
references.pmid: 15781643
references.citation: Nucleic Acids Res. 1989 Jul 25;17(14):5489-500
references.pmid: 2762147
references.citation: FEBS Lett. 1996 Nov 18;397(2-3):253-9
references.pmid: 8955358
references.citation: Nucleic Acids Res. 1997 Jul 15;25(14):2930-7
references.pmid: 9207045
references.citation: J Biol Chem. 2003 Aug 15;278(33):30540-7
references.pmid: 12764135
references.citation: BMC Cancer. 2006 Oct 24;6:252
references.pmid: 17062133
references.citation: Int J Dermatol. 2009 Jun;48(6):579-83
references.pmid: 19538364
references.citation: Cytokine Growth Factor Rev. 2001 Mar;12(1):1-8
references.pmid: 11312113
references.citation: J Biol Chem. 2005 Apr 1;280(13):13037-46
references.pmid: 15677458
references.citation: EMBO J. 2000 May 15;19(10):2280-91
references.pmid: 10811619
references.citation: Dev Dyn. 1996 Feb;205(2):114-25
references.pmid: 8834472
references.citation: Annu Rev Cell Dev Biol. 2005;21:659-93
references.pmid: 16212511
references.citation: Genes Dev. 2005 Dec 1;19(23):2783-810
references.pmid: 16322555
references.citation: J Am Soc Nephrol. 2006 Oct;17(10):2781-91
references.pmid: 16959829
references.citation: J Biol Chem. 2008 May 9;283(19):13269-79
references.pmid: 18334480
references.citation: Science. 1999 Oct 22;286(5440):771-4
references.pmid: 10531062
references.citation: Hum Pathol. 2008 Mar;39(3):403-9
references.pmid: 18261624
references.citation: J Virol. 1991 Sep;65(9):4929-35
references.pmid: 1870207
references.citation: Mol Cell Biol. 2007 Jan;27(1):324-39
references.pmid: 17074815
references.citation: Blood. 1995 Sep 15;86(6):2146-55
references.pmid: 7662963
references.citation: J Neurosci. 2009 Apr 1;29(13):4312-21
references.pmid: 19339625
references.citation: Kidney Int. 2006 May;69(10):1733-40
references.pmid: 16625151
references.citation: Nat Rev Cancer. 2006 Jul;6(7):506-20
references.pmid: 16794634
references.citation: J Biol Chem. 2006 Nov 3;281(44):33008-18
references.pmid: 16966324
references.citation: Nucleic Acids Res. 1993 Sep 25;21(19):4632-8
references.pmid: 8233802
references.citation: Mol Cell Biol. 2003 Aug;23(15):5446-59
references.pmid: 12861029
references.citation: J Biol Chem. 2009 Oct 23;284(43):29988-96
references.pmid: 19717568
references.citation: Lab Invest. 2005 Nov;85(11):1330-41
references.pmid: 16200078
references.citation: Cell Res. 2009 Jan;19(1):47-57
references.pmid: 19114989
references.citation: Am J Pathol. 2003 Oct;163(4):1539-49
references.pmid: 14507660
references.citation: Mol Cell Biol. 2005 Dec;25(24):10731-44
references.pmid: 16314499
references.citation: Curr Opin Genet Dev. 2004 Feb;14(1):65-70
references.pmid: 15108807
references.citation: Nat Genet. 2002 Jan;30(1):106-9
references.pmid: 11731796
references.citation: J Biol Chem. 2010 Jul 16;285(29):21969-77
references.pmid: 20457602
references.citation: Neuron. 2006 May 4;50(3):389-400
references.pmid: 16675394
references.citation: J Biol Chem. 2002 Aug 9;277(32):28483-90
references.pmid: 12023281
references.citation: EMBO J. 2009 Nov 18;28(22):3500-13
references.pmid: 19745809
references.citation: Cancer Res. 2010 May 15;70(10):4204-13
references.pmid: 20460516
references.citation: Cell. 1989 Oct 20;59(2):293-303
references.pmid: 2553267
references.citation: Genes Dev. 1997 Aug 15;11(16):2029-39
references.pmid: 9284043
references.citation: Am J Pathol. 2010 Mar;176(3):1139-47
references.pmid: 20093492
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12437-42
references.pmid: 16109768
references.citation: Mol Cell Neurosci. 2007 Apr;34(4):603-11
references.pmid: 17292623
references.citation: J Biol Chem. 2010 Feb 5;285(6):3633-3642
references.pmid: 19966340