title: Perfusion CT and US of colorectal cancer liver metastases: a correlative study of two dynamic imaging modalities.
abstract: The purpose of this study was to evaluate the correlation between dynamic-contrast-enhanced computed tomography (DCE-CT) and first-pass dynamic-contrast-enhanced ultrasound (DCE-US) of normal appearing liver parenchyma and of colorectal cancer liver metastases. Thirty patients with hepatic metastases from colorectal cancer underwent DCE-CT and DCE-US. To obtain DCE-US reproducibility measurements, double contrast-passages (2 × 2.4 mL SonoVue intravenous) were acquired. From several DCE-US-derived perfusion indices, the slope-value scored best with a reproducibility concordance correlation coefficient ranging from 0.75-0.93 and overall highest correlation to DCE-CT-derived variables (r = 0.52 to 0.73). The DCE-US-based tumor-to-liver perfusion gradient also showed a low test-retest variability and moderately correlated to DCE-CT (concordance correlation coefficient 0.87-0.92; r = 0.57 to 0.59). To conclude, DCE-US-based slope-value and tumor-to-liver perfusion gradient correlate best with DCE-CT perfusion values. However, both techniques cannot be used interchangeably. DCE-US should be restricted for studies in which a considerable change in perfusion is expected and for patients with a relatively high tumor blood flow at baseline.
authors.affiliation: Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands. mr.meijerink@vumc.nl
authors.forename: Martijn R
authors.initials: MR
authors.lastname: Meijerink
authors.forename: Jan Hein T M
authors.initials: JH
authors.lastname: van Waesberghe
authors.forename: Cors
authors.initials: C
authors.lastname: van Schaik
authors.forename: Epie
authors.initials: E
authors.lastname: Boven
authors.forename: Astrid A M
authors.initials: AA
authors.lastname: van der Veldt
authors.forename: Petrousjka
authors.initials: P
authors.lastname: van den Tol
authors.forename: Sybren
authors.initials: S
authors.lastname: Meijer
authors.forename: Cornelis
authors.initials: C
authors.lastname: van Kuijk
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008099:Liver / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods; D010743:Phospholipids; D011856:Radiographic Image Enhancement / Q000379:methods; D015203:Reproducibility of Results; D013459:Sulfur Hexafluoride; D036542:Tomography, Spiral Computed / Q000379:methods*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D007472:Iohexol; C038192:iopromide; D013459:Sulfur Hexafluoride