Photoinduced drug release from thermosensitive AuNPs-liposome using a AuNPs-switch.
A thermosensitive liposome with embedded AuNPs in a bilayer was prepared using supercritical CO(2). The AuNPs-liposome can absorb a certain wavelength light, convert optical energy into heat, induce phase transition, and release drug. The results show that drug release from the liposome is due to the photothermic effects inducing phase transition of the liposome rather than destruction of the liposome structure.
An
Xueqin
X
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China. anxueqin@ecust.edu.cn
Zhang
Fan
F
Zhu
Yinyan
Y
Shen
Weiguo
W
D001599:Berberine / Q000008:administration & dosage; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D008081:Liposomes / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D044367:Phase Transition; D055668:Photochemical Processes; D014466:Ultraviolet Rays
D003692:Delayed-Action Preparations; D008081:Liposomes; D004364:Pharmaceutical Preparations; D001599:Berberine; D006046:Gold