title: CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment.
abstract: We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD-D) or with PD and Cognitive Impairment, Not Dementia (PD-CIND). We quantified CSF Aβ(42), total tau (T-tau), and phospho-tau (P181-tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls ≤50 years (35), Controls >50 years (115), amnestic Mild Cognitive Impairment (aMCI) (24), AD (49), PD (49), PD-CIND (62), and PD-D (11). We observed expected changes in AD or aMCI compared with age-matched or younger controls. CSF Aβ(42) was reduced in PD-CIND (P < 0.05) and PD-D (P < 0.01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of Aβ(42) may be a common feature of PD-CIND and PD-D.
authors.affiliation: Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Montine
authors.forename: Min
authors.initials: M
authors.lastname: Shi
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Quinn
authors.forename: Elaine R
authors.initials: ER
authors.lastname: Peskind
authors.forename: Suzanne
authors.initials: S
authors.lastname: Craft
authors.forename: Carmen
authors.initials: C
authors.lastname: Ginghina
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Chung
authors.forename: Hojoong
authors.initials: H
authors.lastname: Kim
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Galasko
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
authors.forename: Cyrus P
authors.initials: CP
authors.lastname: Zabetian
authors.forename: James B
authors.initials: JB
authors.lastname: Leverenz
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins
references.citation: Biol Psychiatry. 2008 Nov 15;64(10):850-5
references.pmid: 18395699
references.citation: J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52
references.pmid: 2841426
references.citation: Lancet Neurol. 2008 Aug;7(8):704-14
references.pmid: 18635019
references.citation: Neurology. 2009 Jul 28;73(4):294-301
references.pmid: 19636049
references.citation: Mov Disord. 2009 Nov 15;24(15):2203-10
references.pmid: 19795497
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Am J Clin Pathol. 2008 Apr;129(4):526-9
references.pmid: 18343778
references.citation: Mov Disord. 2007 Sep 15;22(12):1689-707; quiz 1837
references.pmid: 17542011
references.citation: Arch Neurol. 2009 Dec;66(12):1557-62
references.pmid: 20008664
references.citation: Neurology. 1993 Nov;43(11):2412-4
references.pmid: 8232972
references.citation: Arch Neurol. 2007 Mar;64(3):343-9
references.pmid: 17210801
references.citation: J Intern Med. 2004 Sep;256(3):183-94
references.pmid: 15324362
references.citation: J Neurol Sci. 2010 Feb 15;289(1-2):18-22
references.pmid: 19733364
references.citation: EMBO Mol Med. 2009 Nov;1(8-9):371-80
references.pmid: 20049742
references.citation: Neurology. 2007 Aug 14;69(7):631-9
references.pmid: 17698783
references.citation: Ann Neurol. 2009 Apr;65(4):403-13
references.pmid: 19296504
references.citation: Brain. 2010 Mar;133(Pt 3):713-26
references.pmid: 20157014
references.citation: JAMA. 2009 Jul 22;302(4):385-93
references.pmid: 19622817
references.citation: Neurology. 2010 Jan 5;74(1):77-84
references.pmid: 20038776