title: Hemangioma in the newborn: increased incidence after chorionic villus sampling.
abstract: OBJECTIVE
  This study was designed to compare the effects of transcervical chorionic villus sampling (CVS) and amniocentesis on the prevalence of hemangiomas of infancy.
  
  
  METHODS
  This is a cohort study of 250 consecutive assessable transabdominal amniocentesis procedures and 250 consecutive assessable transcervical CVS procedures performed between January and September 2002. Parents were asked to fill out a questionnaire regarding the presence of any type of skin lesions. Based on the responses to the questionnaire, children were invited to undergo a physical examination to confirm hemangiomas.
  
  
  RESULTS
  Questionnaires were returned in 78% of the CVS group (195/250) and in 72% of the amniocentesis group (180/250). Based on the responses in the questionnaire, 78 children in the CVS group and 42 in the amniocentesis group underwent a physical examination. One or more hemangiomas were present in 53 of 195 (27.2%) children in the CVS group versus 17 of 180 (9.4%) children in the amniocentesis group (odds ratio 3.6, 95% CI: 2.0-6.5). There was no difference in congenital abnormalities between the two groups.
  
  
  CONCLUSIONS
  Transcervical CVS is associated with a significantly increased prevalence of hemangiomas compared with amniocentesis. The clinical features of these hemangiomas do not differ from natural hemangiomas and complications of these hemangiomas are very rare.
authors.affiliation: Department of Plastic Surgery, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. bauland@gmail.com
authors.forename: Constantijn G
authors.initials: CG
authors.lastname: Bauland
authors.forename: Jeroen M
authors.initials: JM
authors.lastname: Smit
authors.forename: Lidewij R
authors.initials: LR
authors.lastname: Bartelink
authors.forename: Hans A
authors.initials: HA
authors.lastname: Zondervan
authors.forename: Paul H M
authors.initials: PH
authors.lastname: Spauwen
mesh_terms: D000649:Amniocentesis / Q000009:adverse effects; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006391:Hemangioma / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D009426:Netherlands / Q000453:epidemiology; D016017:Odds Ratio; D010290:Parents; D011247:Pregnancy; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D011795:Surveys and Questionnaires