title: Patterning nanowire and micro-nanoparticle array on micropillar-structured surface: Experiment and modeling.
abstract: DNA molecules in a solution can be immobilized and stretched into a highly ordered array on a solid surface containing micropillars by molecular combing technique. However, the mechanism of this process is not well understood. In this study, we demonstrated the generation of DNA nanostrand array with linear, zigzag, and fork-zigzag patterns and the microfluidic processes are modeled based on a deforming body-fitted grid approach. The simulation results provide insights for explaining the stretching, immobilizing, and patterning of DNA molecules observed in the experiments.
authors.forename: Chung Hsun
authors.initials: CH
authors.lastname: Lin
authors.forename: Jingjiao
authors.initials: J
authors.lastname: Guan
authors.forename: Shiu Wu
authors.initials: SW
authors.lastname: Chau
authors.forename: Shia Chung
authors.initials: SC
authors.lastname: Chen
authors.forename: L James
authors.initials: LJ
authors.lastname: Lee
references.citation: Nature. 1998 Feb 19;391(6669):775-8
references.pmid: 9486645
references.citation: Soft Matter. 2007 Oct 16;3(11):1369-1371
references.pmid: 32900114
references.citation: Science. 1997 Sep 5;277(5331):1518-23
references.pmid: 9278517
references.citation: Science. 1994 Sep 30;265(5181):2096-8
references.pmid: 7522347
references.citation: Angew Chem Int Ed Engl. 1998 Mar 16;37(5):550-575
references.pmid: 29711088
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18321-5
references.pmid: 16352724