title: Intensive care management of children with acute liver failure.
abstract: Acute liver failure is an uncommon condition associated with multi organ involvement, high morbidity and mortality. Etiology of acute liver failure varies with age and geographical location. Most cases of acute liver failure in India are due to infectious causes predominantly viral hepatitis. A significant group with indeterminate causation remains, despite careful investigation. The etiology of acute liver failure in infants is largely metabolic. The mainstay of management is supportive care in an intensive care unit. Monitoring of clinical and biochemical parameters is done frequently until the patient becomes stable. Mortality is predominantly due to raised intracranial pressure, infections and multi-organ failure. Liver transplant is an important life saving procedure for children with acute liver failure.
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Vidyut
authors.initials: V
authors.lastname: Bhatia
authors.forename: Rakesh
authors.initials: R
authors.lastname: Lodha
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology / Q000628:therapy; D002648:Child; D002985:Clinical Protocols; D006501:Hepatic Encephalopathy / Q000628:therapy; D006506:Hepatitis A / Q000150:complications; D006801:Humans; D007194:India; D007223:Infant; D015278:Intensive Care Units, Pediatric; D019586:Intracranial Hypertension / Q000209:etiology / Q000628:therapy; D017114:Liver Failure, Acute / Q000175:diagnosis* / Q000628:therapy* / Q000821:virology; D016031:Liver Transplantation; D008991:Monitoring, Physiologic / Q000379:methods; D012985:Software Design
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