Potential of Baliospermum montanum against compound 48/80-induced systemic anaphylaxis.
BACKGROUND
Decoctions of Baliospermum montanum Müll. Arg. (Euphorbiaceae) leaves are reported to be useful in the treatment of asthma and other respiratory complications in the Ayurvedic system.


OBJECTIVE
To evaluate the mast cell stabilization and antihistaminic activities of the chloroform (BMLC) and ethanol (BMLE) extracts of the leaves of Baliospermum montanum.


METHODS
The stabilization potential was studied on mouse peritoneal mast cells and the antihistaminic activity was carried out by determining the mortality rate of mice treated with toxicant (compound 48/80) and the effect on elevation of histamine release upon degranulation.


RESULTS
The increased number of intact mast cells (43.640 ± 1.7% and 61.57 ± 1.79% at 200 and 400 mg/ kg, respectively) suggested that the BMLC stabilized the mast cell degranulation and showed decreased elevation of histamine.


CONCLUSIONS
BMLC extract was found to be most effective against degranulation and release of histamine from mast cells. Identifying the lead from this plant will be a definite target for treating allergic diseases.
Venkatesh
P
P
School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Mukherjee
Pulok K
PK
Mukherjee
Debajyoti
D
Bandyopadhyay
A
A
Fukui
Hiroyuki
H
Mizuguchi
Hiroyuki
H
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D006633:Histamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D003189:p-Methoxy-N-methylphenethylamine
D006633:Histamine Antagonists; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine