title: Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging.
abstract: Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer. In this study, cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes, and specific fluorescence was detected. MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model. Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection, indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection. The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field. These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea, 505, Banpo-dong, Seoul 137701, Republic of Korea.
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Cho
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Yoon
authors.forename: Eue-Soon
authors.initials: ES
authors.lastname: Jang
authors.forename: Kwan
authors.initials: K
authors.lastname: Soo Hong
authors.forename: Shin
authors.initials: S
authors.lastname: Young Lee
authors.forename: Ok
authors.initials: O
authors.lastname: Ran Kim
authors.forename: Cheongsoo
authors.initials: C
authors.lastname: Park
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Gyu-Chul
authors.initials: GC
authors.lastname: Yi
authors.forename: Kiyuk
authors.initials: K
authors.lastname: Chang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D045744:Cell Line, Tumor; D000068818:Cetuximab; D003110:Colonic Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D066246:ErbB Receptors / Q000032:analysis; D005453:Fluorescence; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D012822:Silicon Dioxide
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D012822:Silicon Dioxide; D066246:ErbB Receptors; D000068818:Cetuximab