title: Towards the development of a portable sensor based on a molecularly imprinted membrane for the rapid determination of salbutamol in pig urine.
abstract: A new type of conductometric probe based on a molecularly imprinted membrane (MIM) for the detection of salbutamol has been designed and fabricated. The probe consists of two parallel screen-printed electrodes (SPE). One of the SPEs was coated with a molecularly imprinted membrane using salbutamol as the template, and the other was modified with a non-molecularly imprinted membrane (N-MIM). Measurements of salbutamol were conducted after the conductometric probe had been connected to a commercial portable conductometer. Multi-sample or successive detections could be easily accomplished by replacing the one-off SPE coated with the salbutamol molecularly imprinted membrane with a new one. The conductometric response of the sensor to the concentration of salbutamol displayed a linear correlation over a range from 50 to 280 nM, with a detection limit of 13.5 nM. The recoveries reached 92.1-98.3% based on pig urine samples. In addition, the sensor based on this new type of probe demonstrated high sensitivity and selectivity for salbutamol.
authors.affiliation: School of Agriculture & Biology, Shanghai Jiaotong University, 800# Dongchuan Road, Shanghai 200240, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Chai
authors.forename: Guoyan
authors.initials: G
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Yao
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000652:urine*; D000420:Albuterol / Q000652:urine*; D000818:Animals; D003217:Conductometry / Q000191:economics / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D004867:Equipment Design; D057230:Limit of Detection; D008567:Membranes, Artificial; D054802:Molecular Imprinting; D034421:Sus scrofa; D013997:Time Factors
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D008567:Membranes, Artificial; D000420:Albuterol