title: [Antiviral activity of 2,3-secotriterpenic hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type].
abstract: Novel hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type have been synthesized via interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of investigation of 2,3-secotriterpenic hydrazones antiviral activity to the strain "Indiana" of vesicular stomatitis virus on two models of mammal's line cell infection, acetylhydrazone 1-cyano-2,3-seco-19beta,28-epoxy-18alpha-olean-3-al has been found to have a high prophylactic activity 0.00016 microg/ml to vesicular stomatitis virus and to inhibit a virus reproduction in primarily infected cells in 0.21 microg/ml concentration.
authors.forename: N V
authors.initials: NV
authors.lastname: Galaĭko
authors.forename: I A
authors.initials: IA
authors.lastname: Tolmacheva
authors.forename: V V
authors.initials: VV
authors.lastname: Grishko
authors.forename: L V
authors.initials: LV
authors.lastname: Volkova
authors.forename: E N
authors.initials: EN
authors.lastname: Prevozchikova
authors.forename: S A
authors.initials: SA
authors.lastname: Pestereva
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D018353:Rhabdoviridae Infections / Q000188:drug therapy*; D013552:Swine; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus; D053978:Pentacyclic Triterpenes
chemical_list: D000998:Antiviral Agents; D006835:Hydrazones; D009828:Oleanolic Acid; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes