title: Plant DNA recombinases: a long way to go.
abstract: DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity. DNA recombinases, a special group of proteins bind to single stranded DNA (ssDNA) nonspecifically and search the double stranded DNA (dsDNA) molecule for a stretch of DNA that is homologous with the bound ssDNA. Recombinase A (RecA) has been well characterized at genetic, biochemical, as well as structural level from prokaryotes. Two homologues of RecA called Rad51 and Dmc1 have been detected in yeast and higher eukaryotes and are known to mediate the homologous recombination in eukaryotes. The biochemistry and mechanism of action of recombinase is important in understanding the process of homologous recombination. Even though considerable progress has been made in yeast and human recombinases, understanding of the plant recombination and recombinases is at nascent stage. Since crop plants are subjected to different breeding techniques, it is important to know the homologous recombination process. This paper focuses on the properties of eukaryotes recombinases and recent developments in the field of plant recombinases Dmc1 and Rad51.
authors.affiliation: Plant Biochemistry Section, Molecular Biology Division, Bhabha Atomic Research Center, Trombay, Mumbai 400 085, India.
authors.forename: Rajani Kant
authors.initials: RK
authors.lastname: Chittela
authors.forename: Jayashree K
authors.initials: JK
authors.lastname: Sainis
references.citation: Plant J. 2001 Jan;25(1):31-41
references.pmid: 11169180
references.citation: DNA Res. 1994;1(1):15-26
references.pmid: 7584025
references.citation: Oncogene. 1996 May 16;12(10):2165-70
references.pmid: 8668342
references.citation: Genetics. 1991 May;128(1):163-73
references.pmid: 1648001
references.citation: Mol Cell. 2001 Feb;7(2):273-82
references.pmid: 11239456
references.citation: Science. 1993 Mar 26;259(5103):1896-9
references.pmid: 8456314
references.citation: J Biol Chem. 1997 Jul 11;272(28):17675-85
references.pmid: 9211918
references.citation: J Mol Biol. 1990 Nov 20;216(2):335-52
references.pmid: 2147722
references.citation: Chromosoma. 2002 Jul;111(2):96-105
references.pmid: 12111332
references.citation: Nat Genet. 1993 Jul;4(3):239-43
references.pmid: 8358431
references.citation: Plant Physiol. 2005 Oct;139(2):896-908
references.pmid: 16169964
references.citation: Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11221-6
references.pmid: 9326590
references.citation: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):463-8
references.pmid: 9012806
references.citation: Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11731-5
references.pmid: 9326679
references.citation: EMBO J. 2000 Dec 15;19(24):6675-85
references.pmid: 11118202
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8537-42
references.pmid: 15937124
references.citation: Nature. 2002 Nov 21;420(6913):287-93
references.pmid: 12442171
references.citation: Nucleic Acids Res. 1998 Apr 1;26(7):1653-9
references.pmid: 9512535
references.citation: Genetics. 1992 Oct;132(2):553-66
references.pmid: 1330826
references.citation: Mol Cell. 2004 May 7;14(3):363-74
references.pmid: 15125839
references.citation: Plant Mol Biol. 1995 May;28(2):281-92
references.pmid: 7599313
references.citation: Microbiol Mol Biol Rev. 2002 Dec;66(4):630-70, table of contents
references.pmid: 12456786
references.citation: Plant Physiol. 2005 Jun;138(2):965-76
references.pmid: 15923332
references.citation: Plant Mol Biol. 2008 Nov;68(4-5):479-91
references.pmid: 18695945
references.citation: Plant Cell. 1999 May;11(5):809-24
references.pmid: 10330467
references.citation: Annu Rev Genet. 2001;35:53-82
references.pmid: 11700277
references.citation: J Mol Biol. 1988 Mar 20;200(2):329-49
references.pmid: 3373533
references.citation: Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8433-9
references.pmid: 11459986
references.citation: Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6577-80
references.pmid: 8341671
references.citation: Chromosoma. 2003 Jul;112(1):17-25
references.pmid: 12811575
references.citation: Proc Natl Acad Sci U S A. 1979 Jan;76(1):126-30
references.pmid: 370822
references.citation: Plant Mol Biol. 2005 Jan;57(1):1-11
references.pmid: 15821864
references.citation: J Biol Chem. 1993 Jan 15;268(2):1292-7
references.pmid: 8419331
references.citation: DNA Repair (Amst). 2006 Jan 5;5(1):1-12
references.pmid: 16202663
references.citation: Proc Natl Acad Sci U S A. 1965 Feb;53:451-9
references.pmid: 14294081
references.citation: Cell. 1996 Nov 15;87(4):757-66
references.pmid: 8929543
references.citation: EMBO Rep. 2001 Apr;2(4):287-91
references.pmid: 11306548
references.citation: J Mol Biol. 2002 Feb 8;316(1):35-49
references.pmid: 11829501
references.citation: Nature. 1992 Jan 23;355(6358):318-25
references.pmid: 1731246
references.citation: FEBS J. 2006 Apr;273(7):1497-506
references.pmid: 16689935
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2959-64
references.pmid: 11880641
references.citation: Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8189-95
references.pmid: 11459952
references.citation: Biochim Biophys Acta. 1996 Jul 24;1312(3):231-6
references.pmid: 8703992
references.citation: J Biol Chem. 2000 Feb 11;275(6):3970-6
references.pmid: 10660552
references.citation: EMBO J. 1999 Nov 15;18(22):6552-60
references.pmid: 10562567
references.citation: Trends Biochem Sci. 2001 Feb;26(2):131-6
references.pmid: 11166572
references.citation: Cell. 1995 Aug 11;82(3):453-61
references.pmid: 7634335
references.citation: Genetics. 1997 May;146(1):401-7
references.pmid: 9136028
references.citation: Plant Cell. 1995 Dec;7(12):2151-61
references.pmid: 8718625
references.citation: Genetics. 1995 Aug;140(4):1389-406
references.pmid: 7498778
references.citation: Nucleic Acids Res. 1993 Apr 11;21(7):1665
references.pmid: 8479919
references.citation: DNA Res. 1995;2(2):89-93
references.pmid: 7584052
references.citation: Mol Cell. 1998 Apr;1(5):697-705
references.pmid: 9660953
references.citation: J Biol Chem. 2001 Nov 9;276(45):41906-12
references.pmid: 11551925
references.citation: Mol Gen Genet. 1998 Feb;257(3):283-91
references.pmid: 9520262
references.citation: Mol Cell. 1998 Apr;1(5):707-18
references.pmid: 9660954
references.citation: Plant J. 1997 Jan;11(1):1-14
references.pmid: 9025299
references.citation: J Mol Biol. 1985 Sep 20;185(2):295-309
references.pmid: 4057248
references.citation: EMBO J. 1991 Jun;10(6):1571-8
references.pmid: 2026150
references.citation: Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10684-8
references.pmid: 10485886
references.citation: Genesis. 2000 Mar;26(3):167-73
references.pmid: 10705376
references.citation: Microbiol Rev. 1994 Sep;58(3):401-65
references.pmid: 7968921
references.citation: Trends Genet. 2005 Mar;21(3):172-81
references.pmid: 15734576
references.citation: EMBO J. 2000 Mar 1;19(5):1148-56
references.pmid: 10698955
references.citation: Plant Mol Biol. 2005 Apr;57(6):819-33
references.pmid: 15952068
references.citation: Genes Dev. 1995 Apr 15;9(8):925-34
references.pmid: 7774810
references.citation: J Mol Biol. 1999 Nov 5;293(4):769-80
references.pmid: 10543966
references.citation: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1711-6
references.pmid: 11172016
references.citation: J Mol Biol. 1985 Jan 20;181(2):281-95
references.pmid: 3981638
references.citation: J Biol Chem. 2003 Jan 24;278(4):2469-78
references.pmid: 12427746
references.citation: Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8000-4
references.pmid: 11607492
references.citation: Nature. 2004 May 27;429(6990):433-7
references.pmid: 15164066
references.citation: EMBO J. 1994 Jan 15;13(2):484-9
references.pmid: 8313893
references.citation: J Biol Chem. 2005 Dec 9;280(49):40980-4
references.pmid: 16204247
references.citation: Trends Biochem Sci. 1998 Jul;23(7):247-51
references.pmid: 9697414
references.citation: Mol Cell. 1998 May;1(6):783-93
references.pmid: 9660962
references.citation: EMBO J. 1990 Oct;9(10):3077-84
references.pmid: 2209538
references.citation: Prog Nucleic Acid Res Mol Biol. 1981;26:265-79
references.pmid: 7025096
references.citation: EMBO J. 1994 Dec 1;13(23):5764-71
references.pmid: 7988572
references.citation: Plant J. 1997 Jun;11(6):1195-206
references.pmid: 9225463
references.citation: Plant J. 2004 Jun;38(6):954-68
references.pmid: 15165187
references.citation: Plant Mol Biol. 2007 Sep;65(1-2):31-42
references.pmid: 17562186
references.citation: Plant Cell. 1992 Mar;4(3):319-332
references.pmid: 12297648
references.citation: Mutat Res. 2004 Mar;566(2):131-67
references.pmid: 15164978
references.citation: Curr Genet. 1997 Feb;31(2):144-57
references.pmid: 9021132
references.citation: Biochim Biophys Acta. 1998 Jul 9;1398(3):353-8
references.pmid: 9655934
references.citation: Mutat Res. 2002 Nov 30;509(1-2):49-78
references.pmid: 12427531
references.citation: Mol Cell Biol. 1997 Dec;17(12):7151-8
references.pmid: 9372947
references.citation: DNA Repair (Amst). 2006 Mar 7;5(3):381-91
references.pmid: 16388992
references.citation: Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7417-22
references.pmid: 9207106
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10596-601
references.pmid: 15249667
references.citation: EMBO J. 1990 Nov;9(11):3437-45
references.pmid: 2170114
references.citation: Nucleic Acids Res. 1996 Feb 1;24(3):470-7
references.pmid: 8602360
references.citation: Genetics. 1966 Jun;53(6):1137-50
references.pmid: 5335129
references.citation: Plant Cell. 1999 Sep;11(9):1623-34
references.pmid: 10488231
references.citation: Science. 1994 Aug 26;265(5176):1241-3
references.pmid: 8066464
references.citation: Nucleic Acids Res. 2008 Aug;36(13):4266-76
references.pmid: 18583359
references.citation: Mol Cell Biol. 1999 Dec;19(12):8686-93
references.pmid: 10567591
references.citation: Cell. 1992 May 1;69(3):457-70
references.pmid: 1581961
references.citation: Nucleic Acids Res. 1998 Mar 1;26(5):1179-84
references.pmid: 9469824
references.citation: Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10477-81
references.pmid: 9724728
references.citation: Nature. 1992 Jan 23;355(6358):374-6
references.pmid: 1731253
references.citation: Plant Cell. 2003 Aug;15(8):1807-16
references.pmid: 12897254
references.citation: Nat Rev Genet. 2008 Jan;9(1):27-37
references.pmid: 18040271
references.citation: Proc Natl Acad Sci U S A. 1985 Jan;82(2):297-301
references.pmid: 2982147
references.citation: Mol Cell Biol. 1996 Dec;16(12):7133-43
references.pmid: 8943369
references.citation: J Mol Biol. 1986 Oct 20;191(4):677-97
references.pmid: 2949085
references.citation: Genomics. 1997 Dec 15;46(3):476-9
references.pmid: 9441753
references.citation: Cell. 1992 May 1;69(3):439-56
references.pmid: 1581960
references.citation: Biochemistry. 1989 Feb 7;28(3):1062-9
references.pmid: 2523733
references.citation: Plant J. 2005 Feb;41(4):533-45
references.pmid: 15686518
references.citation: J Biol Chem. 2001 Mar 23;276(12):8798-806
references.pmid: 11124265
references.citation: Plant Physiol. 2006 Mar;140(3):1059-69
references.pmid: 16415210
references.citation: Mol Cell Biol. 1992 Jul;12(7):3235-46
references.pmid: 1620128
references.citation: Biochemistry. 2005 Apr 26;44(16):6052-8
references.pmid: 15835894
references.citation: Nat Struct Mol Biol. 2004 Aug;11(8):791-6
references.pmid: 15235592