Pandemic influenza A (H1N1) in HIV-1-infected patients.
OBJECTIVE
To characterize the clinical presentation, course and mortality of pandemic influenza in HIV-1-infected patients in Santiago, Chile.


METHODS
Prospective observational study.


RESULTS
Thirty patients were included (three hospitalized), 93% were on HAART, mean CD4(+) cell count was 423 cells/μl and viral load was undetectable in 77% of patients. All patients had fever, 90% had cough, 80% had myalgias, 70% had pharyngeal congestion, 47% had coryza, 47% had odynophagia, 37% had headache and 23% had vomiting. Four patients developed pneumonia. All patients received antiviral therapy and no patient died.


CONCLUSIONS
HIV patients infected by the new influenza A pandemic (H1N1) virus behave similarly to the general population.
Perez
Carlos M
CM
Department of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. cape@med.puc.cl
Dominguez
Maria I
MI
Ceballos
Maria E
ME
Moreno
Cristina
C
Labarca
Jaime A
JA
Rabagliati
Ricardo
R
Vasquez
Patricia
P
Lasso
Martin
M
Serri
Michel
M
D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D002677:Chile; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000472:pathogenicity*; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D058873:Pandemics; D011446:Prospective Studies; D019562:Viral Load