Pseudo-outbreak of adenovirus infection in a neonatal intensive care unit due to a false-positive antigen detection test.
Twenty-eight of 56 infants in a neonatal intensive care unit had stools positive for adenovirus by the Sure-Vue adenovirus test. Virus cultures of conventionally processed and chloroform-extracted stool samples, as well as conventional and real-time PCR tests, were negative for adenovirus. The cause for the 50% false-positive rate with the antigen test was not determined.
Faden
Howard
H
Department of Pediatrics, Division of Infectious Diseases, State University of New York at Buffalo School of Medicine and Biomedical Sciences, and the Women and Children’s Hospital of Buffalo, Buffalo, New York 14222, USA. hfaden@upa.chob.edu
Ramani
Rama
R
Lamson
Daryl
D
St George
Kirsten
K
D000256:Adenoviridae / Q000302:isolation & purification*; D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D000956:Antigens, Viral / Q000032:analysis*; D003428:Cross Infection / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D004196:Disease Outbreaks; D005189:False Positive Reactions; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007223:Infant; D015931:Intensive Care, Neonatal; D008297:Male; D016133:Polymerase Chain Reaction; D014773:Virology / Q000379:methods*; D014776:Virus Cultivation
D000956:Antigens, Viral
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