β-TCP versus autologous bone for repair of alveolar clefts in a goat model.
OBJECTIVE
The aim of this study in goats was to test the hypothesis that a novel synthetic bone substitute beta tricalcium phosphate (β-TCP) can work as well as autologous bone harvested from the iliac crest for grafting and repair of alveolar clefts.


METHODS
Ten adult Dutch milk goats (Capra hircus) were used in a split-mouth study design.


METHODS
Volumetric histologic assessment of new bone formation and radiographic measurement of orthodontic movement of teeth in a formerly created alveolar cleft.


CONCLUSIONS
The synthetic bone substitute β-TCP was shown to result in bone healing similar to that of iliac crest bone. The surgical, orthodontic, and histologic results now warrant the testing of β-TCP in the human cleft situation.
de Ruiter
Ad
A
Meijer
Gert
G
Dormaar
Titiaan
T
Janssen
Nard
N
van der Bilt
Andries
A
Slootweg
Piet
P
de Bruijn
Joost
J
van Rijn
Linda
L
Koole
Ronald
R
D000539:Alveolar Process / Q000601:surgery*; D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002972:Cleft Palate / Q000601:surgery*; D004195:Disease Models, Animal; D006041:Goats; D007085:Ilium / Q000637:transplantation*; D016382:Orthodontic Appliance Design; D017289:Orthodontic Appliances, Functional; D010012:Osteogenesis; D014182:Transplantation, Autologous
D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate