title: Selective determination of ertapenem and imipenem in the presence of their degradants.
abstract: Stability-indicative determination of ertapenem (E(RTM)) and imipenem (I(MPM)) in the presence of their corresponding open-ring degradation products, the metabolites, is investigated. The degradation products have been isolated via acid-degradation, characterized, and confirmed. Selective quantification of E(RTM) or I(MPM) singly in bulk form, pharmaceutical formulations, and/or in the presence of their corresponding degradants is demonstrated. The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions. Among the chromatographic techniques adopted for quantification are coupled thin layer chromatography-densitometry and high-performance liquid chromatography.
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini St, ET-11562, Cairo, Egypt. eamoety@hotmail.com
authors.forename: Ezzat M
authors.initials: EM
authors.lastname: Abdel-Moety
authors.forename: Nariman A
authors.initials: NA
authors.lastname: Elragehy
authors.forename: Nagiba Y
authors.initials: NY
authors.lastname: Hassan
authors.forename: Mamdouh R
authors.initials: MR
authors.lastname: Rezk
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D000077727:Ertapenem; D015378:Imipenem / Q000032:analysis / Q000737:chemistry; D007700:Kinetics; D016014:Linear Models; D047090:beta-Lactams / Q000032:analysis / Q000737:chemistry
chemical_list: D047090:beta-Lactams; D015378:Imipenem; D000077727:Ertapenem