title: Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
abstract: Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 μM. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
authors.forename: He Zhong
authors.initials: HZ
authors.lastname: Jiang
authors.forename: Xiao Fang
authors.initials: XF
authors.lastname: Quan
authors.forename: Wei Xi
authors.initials: WX
authors.lastname: Tian
authors.forename: Jiang Miao
authors.initials: JM
authors.lastname: Hu
authors.forename: Peng Cheng
authors.initials: PC
authors.lastname: Wang
authors.forename: Sheng Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.forename: Zhong Quan
authors.initials: ZQ
authors.lastname: Cheng
authors.forename: Wen Juan
authors.initials: WJ
authors.lastname: Liang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiao Feng
authors.initials: XF
authors.lastname: Ma
authors.forename: You Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002645:Chickens; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D029762:Garcinia mangostana / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D001577:Benzophenones; D004791:Enzyme Inhibitors; D010636:Phenols; D044004:Xanthones; D064429:Fatty Acid Synthases