How to measure the transmetallation of a gadolinium complex.
The suitability of paramagnetic complexes as contrast agents depends not only on their relaxivity but also on their stability and inertness towards transmetallation processes by endogenous ions. In this work, we describe a convenient method to study the stability of paramagnetic Gd complexes through the evolution of the paramagnetic longitudinal relaxation rate of water protons at 37 °C.
Laurent
S
S
Department of General, Organic and Biomedical Chemistry, Laboratory of NMR and Molecular Imaging, University of Mons, 19 Avenue Maistriau, B-7000 Mons, Belgium.
Vander Elst
L
L
Henoumont
C
C
Muller
R N
RN
D003287:Contrast Media; D005682:Gadolinium / Q000737:chemistry*; D007477:Ions; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry*; D011522:Protons; D013816:Thermodynamics; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D003287:Contrast Media; D007477:Ions; D008024:Ligands; D009942:Organometallic Compounds; D011522:Protons; D014867:Water; D005682:Gadolinium; D015032:Zinc