Single nucleotide polymorphisms in the phospholipase A2 receptor gene are associated with genetic susceptibility to idiopathic membranous nephropathy.
BACKGROUND
The phospholipase A(2) receptor (PLA2R) is a major antigen found in patients with idiopathic membranous nephropathy (MN). The relationship of genetic polymorphisms of PLA2R with the susceptibility and clinical outcomes of this disease is unknown.


METHODS
We studied 199 patients with idiopathic MN followed up for 3.7 ± 3.2 years. We enrolled 33 patients with secondary MN and 356 subjects with normal blood pressure and no proteinuria. PLA2R single nucleotide polymorphisms (SNPs) were genotyped.


RESULTS
The allele frequencies of C in rs35771982 and G in rs3828323 were 73.6 and 73.9%, respectively. Subjects with the CC genotype in rs35771982 had a higher susceptibility to idiopathic MN compared to subjects with other genotypes (odds ratio 2.6; 95% confidence interval 1.8-4.0). Patients with secondary MN were not different from controls with regard to PLA2R genotype. No impact of genetic polymorphisms on renal survival was detected.


CONCLUSIONS
The findings of this study suggest that PLA2R SNPs might be associated with the risk of developing MN.
Kim
Sejoong
S
Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
Chin
Ho Jun
HJ
Na
Ki Young
KY
Kim
Suhnggwon
S
Oh
Jieun
J
Chung
Wookyung
W
Noh
Jung Woo
JW
Lee
Young Ki
YK
Cho
Jong Tae
JT
Lee
Eun Kyoung
EK
Chae
Dong-Wan
DW
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054507:Receptors, Phospholipase A2 / Q000235:genetics*
D054507:Receptors, Phospholipase A2