A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles.
This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporality, providing a new way to obtain program or temporality release for multiple agents. Particularly, this is potential applications in the field of tissue engineering, sutures and wound dressings.
Wang
Yazhou
Y
Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
Wang
Bochu
B
Qiao
Weili
W
Yin
Tieying
T
D001458:Bandages; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations; D006801:Humans; D008970:Molecular Weight; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009288:Naproxen / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011091:Polyesters / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D013537:Sutures; D023822:Tissue Engineering
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011091:Polyesters; D012235:Rhodamines; D009288:Naproxen; D048271:Chitosan; C029773:rhodamine B