title: Infectious diseases in the nursing home setting: challenges and opportunities for clinical investigation.
abstract: The global population is aging. With the high prevalence of dementia and functional decline in older Americans, many aging adults with disabilities reside in nursing homes in their final stage of life. Immunosenescence, multiple comorbid diseases, and grouped quarter living all coalesce in nursing home residents to increase the risk for infectious disease. The unique issues involved with diagnosis, prognosis, and management of infectious diseases in nursing home residents make research based in the nursing home setting both necessary and exciting for the physician investigator. This review discusses the opportunities and challenges involved with research of the evolving public health problem of infections among nursing home residents.
authors.affiliation: Infectious Diseases Section, Yale University School of Medicine, New Haven, Connecticut, USA. manisha.juthanimehta@yale.edu
authors.forename: Manisha
authors.initials: M
authors.lastname: Juthani-Mehta
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Quagliarello
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D035843:Biomedical Research / Q000379:methods; D003140:Communicable Disease Control / Q000379:methods*; D003141:Communicable Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D009735:Nursing Homes; D016032:Randomized Controlled Trials as Topic; D014481:United States / Q000453:epidemiology
references.citation: JAMA. 2007 Jul 25;298(4):413-22
references.pmid: 17652295
references.citation: Am J Med. 1987 Jul;83(1):27-33
references.pmid: 3300325
references.citation: Res Nurs Health. 2009 Feb;32(1):110-21
references.pmid: 19035619
references.citation: BMC Health Serv Res. 2002 Sep 03;2(1):17
references.pmid: 12207826
references.citation: Am J Epidemiol. 2003 Jan 1;157(1):40-7
references.pmid: 12505889
references.citation: J Am Geriatr Soc. 2008 Dec;56(12):2340-8
references.pmid: 19093934
references.citation: J Am Geriatr Soc. 2009 Jul;57(7):1226-31
references.pmid: 19558483
references.citation: J Immunol. 2007 Jan 15;178(2):970-5
references.pmid: 17202359
references.citation: JAMA. 2006 Jun 7;295(21):2503-10
references.pmid: 16757722
references.citation: Am J Med. 1986 Dec;81(6):979-82
references.pmid: 3799658
references.citation: BMJ. 2005 Sep 24;331(7518):669
references.pmid: 16150741
references.citation: Clin Infect Dis. 2005 Jan 1;40(1):1-6
references.pmid: 15614684
references.citation: MMWR Morb Mortal Wkly Rep. 2003 Feb 14;52(6):101-4, 106
references.pmid: 12645839
references.citation: Clin Infect Dis. 2004 Dec 1;39(11):1642-50
references.pmid: 15578365
references.citation: J Infect Dis. 2007 Jun 1;195(11):1590-7
references.pmid: 17471428
references.citation: Infect Control Hosp Epidemiol. 2008 Aug;29(8):754-9
references.pmid: 18624650
references.citation: Clin Infect Dis. 2008 May 1;46(9):1368-73
references.pmid: 18419438
references.citation: Am J Infect Control. 1999 Feb;27(1):20-6
references.pmid: 9949374
references.citation: J Urol. 2005 Apr;173(4):1065-6
references.pmid: 15758702
references.citation: JAMA. 2005 Dec 7;294(21):2712-9
references.pmid: 16333006
references.citation: Clin Geriatr Med. 2007 Aug;23(3):669-85, viii-ix
references.pmid: 17631240
references.citation: Clin Infect Dis. 2005 Jan 1;40(1):114-22
references.pmid: 15614700
references.citation: Am J Infect Control. 2008 Sep;36(7):472-5
references.pmid: 18786449
references.citation: Infect Control Hosp Epidemiol. 2005 Mar;26(3):231-8
references.pmid: 15796273
references.citation: J Gen Intern Med. 2008 Jun;23(6):816-20
references.pmid: 18421507
references.citation: Gerontologist. 1995 Apr;35(2):172-8
references.pmid: 7750773
references.citation: J Am Geriatr Soc. 2009 Jun;57(6):963-70
references.pmid: 19490243
references.citation: J Am Geriatr Soc. 2004 May;52(5):707-11
references.pmid: 15086649
references.citation: Arch Intern Med. 2005 Nov 28;165(21):2514-20
references.pmid: 16314549
references.citation: Vital Health Stat 13. 2009 Jun;(167):1-155
references.pmid: 19655659
references.citation: Clin Infect Dis. 2009 Jan 15;48(2):149-71
references.pmid: 19072244