New antifungal steroids from Turbinaria conoides (J. Agardh) Kutzing.
Two new steroids 3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene (1) and 14,15,18,20-diepoxyturbinarin (3), together with a known compound, fucosterol (2), were isolated from the cyclohexane extract of Turbinaria conoides. The structures were elucidated on the basis of spectroscopic evidence. The isolated compounds were screened against a panel of microorganisms. Minimum inhibitory concentrations (MICs) were determined by the standard broth dilution method. Compounds 1-3 exhibited moderate antibacterial activity against the tested bacteria and inhibited the fungal growth with MIC values ranging from 2 to 16 microg mL(-1). Compound 3 was found to be most potent against Aspergillus niger, with an MIC value of 2.0 microg mL(-1). The isolation of antifungal compounds from T. conoides is reported for the first time. These results suggested that 14,15,18,20-diepoxyturbinarin (3) could be developed as a new lead antifungal agent.
Kumar
S Sadish
SS
Department of Pharmaceutical Chemistry, I.T.S. Paramedical College, Ghaziabad, Uttar Pradesh, India. jesisjes@yahoo.co.in
Kumar
Y
Y
Khan
M S Y
MS
Gupta
V
V
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology
D000935:Antifungal Agents; D013256:Steroids