title: Black-white divergence in the relation of white blood cell count to metabolic syndrome in preadolescents, adolescents, and young adults: the Bogalusa Heart Study.
abstract: OBJECTIVE
  To examine the association between white blood cell (WBC) count and metabolic syndrome (MetS) by growth periods in black versus white individuals in the general population.
  
  
  METHODS
  The study cohort consisted of 4,184 black and white preadolescents, adolescents, and adults. In this cohort, 743 adults were followed for 8.1-20.8 years longitudinally.
  
  
  RESULTS
  White versus black subjects had a significantly higher WBC count in all age-groups. WBC count was associated with more MetS components in whites than in blacks. Mean values of WBC increased significantly with increasing number of MetS components with adverse levels in adolescents and adults, with a stronger trend in whites. WBC count was longitudinally associated with MetS in whites only (P<0.001).
  
  
  CONCLUSIONS
  The findings on the association between higher WBC count and MetS beginning in childhood, particularly in whites, underscore a potentially mechanistic link between systemic inflammation, MetS, and cardiovascular risk.
authors.affiliation: Department of Epidemiology, Tulane Center for Cardiovascular Health, Tulane University, New Orleans, Louisiana, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Sathanur R
authors.initials: SR
authors.lastname: Srinivasan
authors.forename: Jihua
authors.initials: J
authors.lastname: Xu
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Berenson
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D055105:Waist Circumference; D044465:White People; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL
references.citation: Diabetes. 2000 Jun;49(6):1042-8
references.pmid: 10866058
references.citation: Am J Epidemiol. 1992 Sep 1;136(5):525-37
references.pmid: 1442716
references.citation: J Pediatr. 2009 Sep;155(3):S7.e7-11
references.pmid: 19732569
references.citation: Lancet. 1971 Nov;2(7732):1021-3
references.pmid: 4108075
references.citation: J Am Coll Cardiol. 2004 Nov 16;44(10):1945-56
references.pmid: 15542275
references.citation: Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):629-36
references.pmid: 18174459
references.citation: Metabolism. 2006 Jun;55(6):699-705
references.pmid: 16713426
references.citation: Diabetes Care. 2004 Mar;27(3):813-23
references.pmid: 14988310
references.citation: Int J Epidemiol. 1990 Dec;19(4):889-93
references.pmid: 2084017
references.citation: Diabetes Care. 2010 Feb;33(2):411-3
references.pmid: 19918010
references.citation: Endocr J. 2006 Feb;53(1):133-9
references.pmid: 16543683
references.citation: Arch Intern Med. 2003 Feb 24;163(4):427-36
references.pmid: 12588201