title: Pyrimidine based highly sensitive fluorescent receptor for Al3+ showing dual signalling mechanism.
abstract: A new fluorescent probe (5-[(4-diethylamino-2-hydroxy-benzylidene)-amino]-1H-pyrimidine-2, 4-dione) (Receptor 1) has been synthesized by the Schiff base condensation of 5-aminouracil with 4-(diethylamino)salicylaldehyde. The receptor 1 exhibits high selectively for Al(3+) in DMSO as well as in aqueous solution even in the presence of biologically relevant cations such as Na(+), K(+), Ca(2+), Mg(2+), Pb(2+) and several transition metal ions. The lowest detection limit for the receptor 1 was found to be 1.62 × 10(-10) M with its linear response towards Al(3+) in the concentration range of 1.75 × 10(-9) to 3.3 × 10(-8) M in DMSO. Receptor 1 is the first ever example where a single molecular probe is able to show imine (C=N) isomerization inhibition along with twisted intramolecular charge transfer (TICT) in combinatorial fashion.
authors.affiliation: Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India. drkaushalbhu@yahoo.co.in
authors.forename: K K
authors.initials: KK
authors.lastname: Upadhyay
authors.forename: Ajit
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D000535:Aluminum / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D007536:Isomerism; D057230:Limit of Detection; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013053:Spectrophotometry; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000447:Aldehydes; D005456:Fluorescent Dyes; D012545:Schiff Bases; C013243:salicylaldehyde; D014498:Uracil; D000535:Aluminum; C011166:5-aminouracil