Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.
Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation.
Dai
Jingqiu
J
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
Sorribas
Analia
A
Yoshida
Wesley Y
WY
Kelly
Michelle
M
Williams
Philip G
PG
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D013256:Steroids; C553018:topsentinol K; C553020:topsentinol K trisulfate; C553019:topsentinol L; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human
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