title: A simple chromatographic route for the isolation of meso diaminopimelic acid.
abstract: Meso diaminopimelic acid is an important noncoded amino acid found in Gram-negative bacterial peptidoglycan. In spite of its importance, this stereoisomer is not available commercially. A simple, economical procedure was developed for the isolation of pure meso diaminopimelic acid via an high-performance liquid chromatography separation. In our new approach, the underivatized three isomers of diaminopimelic acid were separated on a crown ether-based chiral stationary phase. For the structure identification, (1)H NMR spectroscopy was applied.
authors.affiliation: Department of Medical Chemistry, University of Szeged, Szeged, Hungary.
authors.forename: Gábor K
authors.initials: GK
authors.lastname: Tóth
authors.forename: Anasztázia
authors.initials: A
authors.lastname: Hetényi
authors.forename: István
authors.initials: I
authors.lastname: Ilisz
authors.forename: Antal
authors.initials: A
authors.lastname: Péter
mesh_terms: D056148:Chromatography, Reverse-Phase / Q000379:methods*; D043844:Crown Ethers / Q000737:chemistry*; D003960:Diaminopimelic Acid / Q000138:chemical synthesis* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D043844:Crown Ethers; D003960:Diaminopimelic Acid