Estrogens repress PGC1-α expression in the uterus.
PGC-1α is a transcriptional coactivator that is highly involved in several aspects of regulation of metabolism, including mitochondrial biogenesis and activity. Using several in vivo models, we here report that the expression of PGC-1α is repressed by estrogens in the mouse specifically in the uterus. In the absence of estrogens, expression of PGC-1α target genes involved in mitochondrial activity is activated, but not mitochondrial biogenesis. Regulation of PGC-1α expression by estrogens also occurs in Ishikawa human uterine cells at the promoter level and involve modulation of c-jun expression.
Macari
Claire
C
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Institut Fédératif Biosciences Gerland Lyon Sud, Université Lyon 1, CNRS UMR5242, INRA, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.
Teyssier
Catherine
C
Tribollet
Violaine
V
Mouzat
Kevin
K
Forcet
Christelle
C
Horard
Béatrice
B
Lobaccaro
Jean-Marc
JM
Vanacker
Jean-Marc
JM
D000818:Animals; D015536:Down-Regulation / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D011401:Promoter Regions, Genetic; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism*
D004967:Estrogens; D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D016755:Proto-Oncogene Proteins c-jun; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D004958:Estradiol