title: Multiple sclerosis-associated fatigue.
abstract: Fatigue is an extremely prevalent issue for multiple sclerosis (MS) patients. Fatigue can affect quality of life, depression, anxiety, motor function and sleep patterns. There are a number of available rating scales designed to detect and assess fatigue. However, the pathophysiology of fatigue is still not completely understood and the treatment of this symptom remains difficult. A number of clinical trials for fatigue in MS have shown some benefit with different interventions, including medication, physical activity and cognitive-behavioral therapy. Nonetheless, further research and the development of more targeted therapies are needed to improve the management of fatigue.
authors.affiliation: Stony Brook University Medical Center, Department of Neurology, Stony Brook, NY 11794-8121, USA. lkrupp@notes.cc.sunysb.edu
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Krupp
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Serafin
authors.forename: Christopher
authors.initials: C
authors.lastname: Christodoulou
mesh_terms: D005221:Fatigue / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology