title: Neuropathic pain-like alterations in muscle nociceptor function associated with vibration-induced muscle pain.
abstract: We recently developed a rodent model of the painful muscle disorders induced by occupational exposure to vibration. In the present study we used this model to evaluate the function of sensory neurons innervating the vibration-exposed gastrocnemius muscle. Activity of 74 vibration-exposed and 40 control nociceptors, with mechanical receptive fields in the gastrocnemius muscle, were recorded. In vibration-exposed rats ∼15% of nociceptors demonstrated an intense and long-lasting barrage of action potentials in response to sustained suprathreshold mechanical stimulation (average of 2635 action potentials with frequency of ∼44Hz during a 1min suprathreshold stimulus) much greater than that has been reported to be produced even by potent inflammatory mediators. While these high-firing nociceptors had lower mechanical thresholds than the remaining nociceptors, exposure to vibration had no effect on conduction velocity and did not induce spontaneous activity. Hyperactivity was not observed in any of 19 neurons from vibration-exposed rats pretreated with intrathecal antisense for the IL-6 receptor subunit gp130. Since vibration can injure peripheral nerves and IL-6 has been implicated in painful peripheral neuropathies, we suggest that the dramatic change in sensory neuron function and development of muscles pain, induced by exposure to vibration, reflects a neuropathic muscle pain syndrome.
authors.affiliation: Department Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143, USA Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Chen
authors.forename: Paul G
authors.initials: PG
authors.lastname: Green
authors.forename: Jon D
authors.initials: JD
authors.lastname: Levine
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D050822:Cytokine Receptor gp130 / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D006614:Hindlimb / Q000294:innervation; D006930:Hyperalgesia / Q000503:physiopathology; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000473:pathology* / Q000502:physiology*; D009437:Neuralgia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D009619:Nociceptors / Q000502:physiology*; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage; D017288:Pain Threshold / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014732:Vibration / Q000009:adverse effects*
chemical_list: C494200:Il6st protein, mouse; D015850:Interleukin-6; D020319:Oligodeoxyribonucleotides, Antisense; D050822:Cytokine Receptor gp130
references.citation: Toxicol Rev. 2005;24(1):37-49
references.pmid: 16042503
references.citation: Neuroscience. 2008 Mar 18;152(2):521-5
references.pmid: 18280048
references.citation: Neuroscience. 2003;120(1):219-26
references.pmid: 12849754
references.citation: Br J Ind Med. 1989 Mar;46(3):157-64
references.pmid: 2930726
references.citation: J Physiol. 1999 Mar 15;515 ( Pt 3):799-811
references.pmid: 10066906
references.citation: Emerg Infect Dis. 2007 Feb;13(2):243-7
references.pmid: 17479886
references.citation: Science. 1981 Sep 25;213(4515):1527-9
references.pmid: 7280675
references.citation: Occup Environ Med. 1994 Feb;51(2):130-5
references.pmid: 8111461
references.citation: Int Arch Occup Environ Health. 2000 Nov;73(8):519-27
references.pmid: 11100946
references.citation: Muscle Nerve. 2009 Jun;39(6):770-5
references.pmid: 19306323
references.citation: J Physiol. 2009 Jan 15;587(1):183-93
references.pmid: 19015194
references.citation: Acta Neuropathol. 2003 Jun;105(6):593-602
references.pmid: 12734666
references.citation: Occup Med (Lond). 2009 May;59(3):167-73
references.pmid: 19261895
references.citation: Gan To Kagaku Ryoho. 2006 Oct;33(10):1445-52
references.pmid: 17033235
references.citation: Muscle Nerve. 2006 Aug;34(2):197-204
references.pmid: 16691604
references.citation: Arch Phys Med Rehabil. 1991 Sep;72(10):755-8
references.pmid: 1929800
references.citation: Dtsch Arztebl Int. 2008 Mar;105(12):214-9
references.pmid: 19629211
references.citation: Acta Anat (Basel). 1975;92(4):543-59
references.pmid: 1189887
references.citation: Baillieres Best Pract Res Clin Rheumatol. 1999 Jun;13(2):217-30
references.pmid: 10952861
references.citation: Int Arch Occup Environ Health. 2008 Apr;81(5):595-602
references.pmid: 17924132
references.citation: Eur J Pain. 2010 Mar;14(3):236-44
references.pmid: 19560379
references.citation: J Neurol Sci. 2006 Nov 15;249(2):175-9
references.pmid: 16920153
references.citation: J Hand Surg Br. 1996 Jun;21(3):315-9
references.pmid: 8771466
references.citation: J Pharmacol Exp Ther. 2009 Jan;328(1):223-30
references.pmid: 18955588
references.citation: Br J Sports Med. 1996 Dec;30(4):319-23
references.pmid: 9015594
references.citation: Eur J Haematol. 1995 Sep;55(3):205-6
references.pmid: 7672095
references.citation: J Neurosci Methods. 1995 Aug;60(1-2):61-8
references.pmid: 8544488
references.citation: Brain Res Mol Brain Res. 1998 Nov 20;62(2):228-35
references.pmid: 9813345
references.citation: Pain. 2005 Mar;114(1-2):168-76
references.pmid: 15733642
references.citation: Eur J Pain. 2010 Aug;14(7):682.e1-12
references.pmid: 19959384
references.citation: J Neurosci. 1995 Dec;15(12):7757-68
references.pmid: 8613717
references.citation: J Neurosci. 1997 Jan 15;17(2):735-44
references.pmid: 8987795
references.citation: Neurosci Lett. 1999 May 28;267(2):105-8
references.pmid: 10400223
references.citation: Eur J Hum Genet. 2009 Oct;17(10):1359-62
references.pmid: 19367323
references.citation: Neuron. 2003 Jul 31;39(3):497-511
references.pmid: 12895423
references.citation: J Pain. 2006 Dec;7(12):884-91
references.pmid: 17157774
references.citation: J Hand Surg Br. 2001 Oct;26(5):471-4
references.pmid: 11560431
references.citation: Arthritis Rheum. 2007 Jan;56(1):351-9
references.pmid: 17195239
references.citation: Neurosci Lett. 1996 Oct 25;218(1):17-20
references.pmid: 8939470
references.citation: Handb Exp Pharmacol. 2009;(194):3-30
references.pmid: 19655103
references.citation: Arch Environ Health. 2001 May-Jun;56(3):254-6
references.pmid: 11480502
references.citation: Cardiovasc Surg. 1998 Feb;6(1):1-9
references.pmid: 9546840
references.citation: Am Ind Hyg Assoc J. 1990 Sep;51(9):510-8
references.pmid: 2220569
references.citation: Neurosci Lett. 1998 Oct 30;256(1):17-20
references.pmid: 9832206
references.citation: Scand J Work Environ Health. 1988 Feb;14(1):31-5
references.pmid: 3353694
references.citation: Pain. 1987 Nov;31(2):263-276
references.pmid: 2448728
references.citation: Brain Res. 2003 Sep 12;984(1-2):54-62
references.pmid: 12932839
references.citation: Lancet. 1997 Mar 29;349(9056):943-7
references.pmid: 9093264
references.citation: Clin Neurol Neurosurg. 2005 Apr;107(3):181-6
references.pmid: 15823672
references.citation: PM R. 2009 Aug;1(8):744-54
references.pmid: 19695528
references.citation: Int Arch Occup Environ Health. 1983;52(1):17-24
references.pmid: 6307889
references.citation: Int Rev Neurobiol. 2009;85:179-90
references.pmid: 19607970
references.citation: Occup Ther Int. 2007;14(3):156-69
references.pmid: 17624874
references.citation: J Physiol. 1965 Apr;177:377-97
references.pmid: 14321486
references.citation: J Neurophysiol. 2001 Apr;85(4):1595-602
references.pmid: 11287483
references.citation: Am J Ind Med. 1999 Aug;36(2):248-59
references.pmid: 10398933
references.citation: J Neuroimmunol. 2005 Oct;167(1-2):13-22
references.pmid: 16026858
references.citation: J Neurosci. 2004 May 5;24(18):4444-52
references.pmid: 15128858
references.citation: CNS Neurol Disord Drug Targets. 2009 Jun;8(3):175-83
references.pmid: 19601815
references.citation: J Orofac Pain. 2001 Spring;15(2):117-45
references.pmid: 11443825
references.citation: J Pain. 2010 Apr;11(4):369-77
references.pmid: 19962353
references.citation: J Neurol Neurosurg Psychiatry. 2008 Oct;79(10):1171-9
references.pmid: 18356256
references.citation: J Hand Surg Br. 2003 Apr;28(2):165-71
references.pmid: 12631491
references.citation: Scand J Work Environ Health. 1987 Aug;13(4):326-9
references.pmid: 3433033
references.citation: J Neurochem. 2005 May;93(3):664-73
references.pmid: 15836625
references.citation: J Neurol Neurosurg Psychiatry. 2008 Nov;79(11):1268-73
references.pmid: 18550631
references.citation: Cent Eur J Public Health. 1995;3 Suppl:97-102
references.pmid: 9150983
references.citation: Eur J Neurosci. 2003 May;17(9):1847-52
references.pmid: 12752784
references.citation: Int J Psychophysiol. 2004 Jan;51(2):117-26
references.pmid: 14693361
references.citation: Genomics. 1992 Nov;14(3):666-72
references.pmid: 1427893
references.citation: Scand J Plast Reconstr Surg Hand Surg. 2001 Sep;35(3):225-32
references.pmid: 11680390
references.citation: Occup Environ Med. 1997 Feb;54(2):90-5
references.pmid: 9072015
references.citation: Clin Orthop Relat Res. 1998 Jun;(351):107-26
references.pmid: 9646754
references.citation: Rheumatology (Oxford). 1999 Jul;38(7):636-9
references.pmid: 10461477
references.citation: Pain. 2008 Mar;135(1-2):98-107
references.pmid: 17590515
references.citation: J Physiol. 1995 Mar 15;483 ( Pt 3):747-58
references.pmid: 7776255
references.citation: J Occup Environ Med. 2010 Jun;52(6):584-94
references.pmid: 20523237
references.citation: Am J Med. 2009 Oct;122(10 Suppl):S13-21
references.pmid: 19801048
references.citation: J Neurosci. 1987 Sep;7(9):2821-36
references.pmid: 3498016
references.citation: Int Arch Occup Environ Health. 2007 Feb;80(4):273-80
references.pmid: 16915392
references.citation: Eur J Neurosci. 2004 Feb;19(3):634-42
references.pmid: 14984413
references.citation: Scand J Work Environ Health. 1986 Aug;12(4 Spec No):280-3
references.pmid: 3775312