Effect of stellate ganglion block on the cerebrovascular system: magnetic resonance angiography study.
BACKGROUND
Several studies have shown that stellate ganglion block (SGB) is an effective treatment for certain cerebrovascular related diseases; however, the direct effect of SGB on the cerebral vasculature is still unknown. The present study investigated the effect of SGB on the cerebral vascular system using magnetic resonance angiography.


METHODS
Time-of-flight magnetic resonance angiography images of 19 healthy female volunteers (mean ages of 46.4 ± 8.9 yr) were obtained before and after SGB with 1.5-T magnetic resonance imaging. The authors determined successful interruption of sympathetic innervation to the head with the appearance of Horner syndrome and conjunctival injection. We measured changes in the average signal intensity and diameter of the major intracranial and extracranial arteries and their branches, which were presented with mean (±SE).


RESULTS
The signal intensity changes were observed mainly in the ipsilateral extracranial vessels; the external carotid artery (11.2%, P < 0.001) and its downstream branches, such as the occipital artery (9.5%, P < 0.001) and superficial temporal artery (14.1%, P < 0.001). In contrast, the intensities of the intracranial arteries did not change with the exception of the ipsilateral ophthalmic artery, which increased significantly (10.0%, P = 0.008). After SGB, only the diameter of the ipsilateral external carotid artery was significantly increased (26.5%, P < 0.001).


CONCLUSIONS
We were able to observe significant changes in the extracranial vessels, whereas the intracranial vessels were relatively unaffected (except for the ophthalmic artery), demonstrating that both perivascular nerve control and sympathetic nerve control mechanisms may contribute to the control of intracranial and extracranial blood vessels, respectively, after SGB.
Kang
Chang-Ki
CK
Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-gu, Incheon, Republic of Korea.
Oh
Seung-Taek
ST
Chung
Rack Kyung
RK
Lee
Hyon
H
Park
Chan-A
CA
Kim
Young-Bo
YB
Yoo
Jeong Hyun
JH
Kim
Dong Yeon
DY
Cho
Zang-Hee
ZH
D000328:Adult; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005730:Ganglionic Blockers / Q000494:pharmacology*; D006732:Horner Syndrome / Q000503:physiopathology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008875:Middle Aged; D013233:Stellate Ganglion / Q000187:drug effects*
D005730:Ganglionic Blockers