Olfactory sensitivity for sperm-attractant aromatic aldehydes: a comparative study in human subjects and spider monkeys.
Using a three-alternative forced-choice ascending staircase procedure, we determined olfactory detection thresholds in 20 human subjects for seven aromatic aldehydes and compared them to those of four spider monkeys tested in parallel using an operant conditioning paradigm. With all seven odorants, both species detected concentrations <1 ppm, and with several odorants single individuals of both species even discriminated concentrations <1 ppb from the solvent. No generalizable species differences in olfactory sensitivity were found despite marked differences in neuroanatomical and genetic features. The across-odorant patterns of sensitivity correlated significantly between humans and spider monkeys, and both species were more sensitive to bourgeonal than to lilial, cyclamal, canthoxal, helional, lyral, and 3-phenylpropanal. No significant correlation between presence/absence of an oxygen-containing moiety attached to the benzene ring or presence/absence of an additional alkyl group next to the functional aldehyde group, and olfactory sensitivity was found in any of the species. However, the presence of a tertiary butyl group in para position (relative to the functional aldehyde group) combined with a lack of an additional alkyl group next to the functional aldehyde group may be responsible for the finding that both species were most sensitive to bourgeonal.
Kjeldmand
Luna
L
IFM Biology, Linköping University, Linköping, Sweden.
Salazar
Laura Teresa Hernandez
LT
Laska
Matthias
M
D000328:Adult; D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D053819:Atelinae; D001522:Behavior, Animal / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants; D055696:Olfactory Perception / Q000187:drug effects / Q000502:physiology*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology*; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
D000447:Aldehydes
Chem Senses. 1999 Apr;24(2):161-70
10321817
J Comp Neurol. 2007 May 20;502(3):468-82
17366613
Chem Senses. 2003 Jul;28(6):467-77
12907584
Am J Phys Anthropol. 2006 Jan;129(1):112-20
16245343
J Comp Neurol. 2007 Jul 1;503(1):1-34
17480025
Chem Senses. 2004 Feb;29(2):143-52
14977811
J Comp Psychol. 2006 May;120(2):106-12
16719588
Physiol Behav. 2003 Feb;78(2):321-9
12576131
J Chem Ecol. 2006 Jun;32(6):1317-31
16770721
Chem Senses. 2005 Jul;30(6):505-11
15961521
J Neurochem. 2006 Apr;97(2):537-44
16539658
Genome Res. 2010 Jan;20(1):1-9
19952139
Science. 2003 Mar 28;299(5615):2054-8
12663925
Chem Senses. 2006 Sep;31(7):655-64
16793858
PLoS Biol. 2004 Jan;2(1):E5
14737185
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4040-5
10097159
Nutr Rev. 2004 Nov;62(11 Pt 2):S218-23; discussion S224-41
15630938
J Exp Zool A Ecol Genet Physiol. 2009 Apr 1;311(4):278-88
19204998
Mol Cell Endocrinol. 2006 May 16;250(1-2):128-36
16413109
J Exp Biol. 2007 Dec;210(Pt 23):4169-78
18025016
Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1970-5
16446455
Atten Percept Psychophys. 2010 Apr;72(3):806-12
20348584
Behav Neurosci. 2003 Dec;117(6):1142-9
14674835
Behav Brain Res. 2006 Feb 28;167(2):349-54
16253352
J Hum Genet. 2006;51(6):505-517
16607462
Chem Senses. 2010 Jun;35(5):427-32
20378596
Chem Senses. 2004 Feb;29(2):101-9
14977806
SAR QSAR Environ Res. 1997;6(3-4):215-54
9487700
J Cell Sci. 2004 Nov 15;117(Pt 24):5835-45
15522887