title: [Simulation research on the movement and deposition of inhalational particles in the human respiratory tract].
abstract: An entire 3-dimensional geometry model from mouth, pharynx, larynx, trachea to triple bifurcation and the mathematics models for the calculation of the fluid flow and inhalational particle movement in the respiratory tract were proposed in this paper. The deposition fraction of inhalational particles in the respiratory tract obtained from the numerical simulation was coincident with the experimental data basically. Particles were traced in the Lagrangian frame, and at the same time, particle deposition fraction and position were recorded based on the models. The movement and deposition of the inhalational particles in the upper respiratory tract were analyzed. The results show that the deposition of inhalational particles in different positions have important correlation with the breathing intensity, particle density and particle diameter; deposition fraction of the inhalational particles in the trachea will increase at high breathing intensity and decrease with particle diameter increased; the deposition fraction of the inhalational particles in the larynx is maximal and can attain 35%, but the influence of the breathing intensity and particle diameter on the deposition fraction is smaller relatively; the deposition fraction of the inhalational particles in the triple bifurcation will decrease observably with particle diameter increased; the deposition fraction of the inhalational particles in the triple bifurcation is higher obviously at medium and small breathing intensity compared with that of high breathing intensity. The simulation results of this paper can provide a foundation for the research of the effect of inhalational particles on the human health and the research of the inhaling remedy in medicine.
authors.affiliation: College of Mechanical and Electrical Engineering, Beijing Jiaotong University, Beijing 100044, China. yinjingjuan@163.com
authors.forename: Jing-juan
authors.initials: JJ
authors.lastname: Yin
authors.forename: Zhi
authors.initials: Z
authors.lastname: Ning
authors.forename: Juan
authors.initials: J
authors.lastname: Fu
authors.forename: Xiao-zhen
authors.initials: XZ
authors.lastname: Lu
mesh_terms: D001980:Bronchi / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009055:Mouth / Q000502:physiology; D010316:Particle Size; D052638:Particulate Matter / Q000032:analysis*; D010614:Pharynx / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012137:Respiratory System; D014132:Trachea / Q000502:physiology
chemical_list: D052638:Particulate Matter