Microarray: an instrument for cancer surgeons of the future?
Microarray enables the study of thousands of genes simultaneously. While still in its infancy as a technique and with a number of barriers to be overcome, microarray is allowing scientists to thoroughly examine the molecular pathways of cancer pathogenesis. However, the adoption of microarray as a clinically applicable technique has been slow coming. Current literature suggests roles in the diagnosis of tumours of unknown origin, in the evaluation of prognostic markers, and in guiding treatment for recurrent and resistant malignancy. This review outlines the science of microarray and draws on clinical examples, including osteosarcoma, breast, prostate and pancreatic carcinomas, to highlight the potential of microarray as a technique of surgical importance.
Broadhead
Matthew L
ML
Department of Orthopaedics University of Melbourne, St. Vincent's Hospital, VIC, Australia.
Clark
Jonathan C M
JC
Dass
Crispin R
CR
Choong
Peter F M
PF
D014408:Biomarkers, Tumor / Q000032:analysis; D005544:Forecasting; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000601:surgery; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods* / Q000639:trends*; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor