title: Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder.
abstract: Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent to which OCD symptom dimensions were associated with episodic memory and attention and executive functions. The symptom dimensions of 63 patients with OCD were assessed using both the Padua Inventory and the Y-BOCS symptom checklist. Then, we administered the Logical Memory (LM) subset of the Wechsler Memory Scale-Revised (WMR-R) test and evaluated inhibition (Stroop test, Trail Making test) and cognitive flexibility (Digit Symbol test, Letter Fluency, and Category Fluency). While associations were observed between scores on the contamination/cleaning dimension and better performances on the LM and Trail Making tests, associations were also observed between scores on the aggressive/checking dimension and poorer performances on the Trail Making test. In addition, we found that scores on the symmetry/ordering dimension were associated with poorer performances on the LM and Trail Making tests. Our results support the hypothesis that different symptoms may represent distinct and partially overlapping neurocognitive networks in OCD patients.
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Shutaro
authors.initials: S
authors.lastname: Nakaaki
authors.forename: Ichiro M
authors.initials: IM
authors.lastname: Omori
authors.forename: Junko
authors.initials: J
authors.lastname: Fujioi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Murata
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tatsumi
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Torii
authors.forename: Masaru
authors.initials: M
authors.lastname: Mimura
authors.forename: Toshi A
authors.initials: TA
authors.lastname: Furukawa
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies