Dabigatran inhibits Staphylococcus aureus coagulase activity.
The ability of Staphylococcus aureus to clot plasma through conformational activation of prothrombin by staphylocoagulase is used to distinguish S. aureus from coagulase-negative staphylococci. We show that while the direct thrombin inhibitor dabigatran inhibits staphylocoagulase activity, the clinical use of dabigatran etexilate is not expected to interfere with direct tube coagulase testing.
Vanassche
Thomas
T
Center for Molecular and Vascular Biology, University of Leuven, B-3000 Leuven, Belgium. thomas.vanassche@med.kuleuven.be
Verhaegen
Jan
J
Peetermans
Willy E
WE
Hoylaerts
Marc F
MF
Verhamme
Peter
P
D001562:Benzimidazoles / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D003030:Coagulase / Q000037:antagonists & inhibitors*; D000069604:Dabigatran; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D013211:Staphylococcus aureus / Q000201:enzymology*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology
D001562:Benzimidazoles; D003030:Coagulase; D004791:Enzyme Inhibitors; D015091:beta-Alanine; D000069604:Dabigatran
Br J Clin Pharmacol. 2007 Sep;64(3):292-303
17506785
Biochim Biophys Acta. 1975 Jan 30;379(1):180-8
1115793
Lancet. 2007 Sep 15;370(9591):949-56
17869635
J Antimicrob Chemother. 2006 Jan;57(1):122-6
16344286
J Med Microbiol. 1994 Oct;41(4):259-63
7932618
J Bacteriol. 1934 Oct;28(4):343-63
16559753
J Clin Microbiol. 2004 Dec;42(12):5739-44
15583307
Infect Immun. 1978 Nov;22(2):473-9
730368
J Thromb Haemost. 2003 Sep;1(9):2060-1
12941055
N Engl J Med. 2009 Dec 10;361(24):2342-52
19966341
J Clin Microbiol. 2005 Sep;43(9):4613-5
16145115
J Clin Microbiol. 2008 Sep;46(9):2924-9
18614649
Thromb Haemost. 2010 Jun;103(6):1116-27
20352166
Microbiol Immunol. 1989;33(12):981-90
2622397
Infect Immun. 1983 Mar;39(3):1236-42
6840839
Am Heart J. 2006 Jun;151(6):1131-8
16781211
Infect Immun. 1985 Sep;49(3):765-9
4040889
J Clin Microbiol. 2007 Jul;45(7):2267-9
17522280
Nature. 2003 Oct 2;425(6957):535-9
14523451
J Clin Microbiol. 2006 Jan;44(1):119-23
16390958
N Engl J Med. 2009 Sep 17;361(12):1139-51
19717844
Infect Immun. 1997 Feb;65(2):466-71
9009298
J Clin Microbiol. 1995 Jan;33(1):50-2
7699065
Biochim Biophys Acta. 1975 Jan 30;379(1):164-71
1167792