Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II.
A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds were found to be moderate active against Mycobacterium tuberculosis. Correlation of structure-biological activity has been done.
Mantu
Dorina
D
Al. I. Cuza University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania.
Luca
Mihaela Cătălina
MC
Moldoveanu
Costel
C
Zbancioc
Gheorghita
G
Mangalagiu
Ionel I
II
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D011724:Pyridazines; C062482:pyridazine