Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.
OBJECTIVE
A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population.


METHODS
Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Result. SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944.


CONCLUSIONS
This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS.
Sánchez
Alejandra
A
Laboratory of Rheumatology, Puerta de Hierro University Hospital, C/Joaquín Rodrigo 2, Majadahonda 28222, Madrid, Spain. malejandra_sanchez@yahoo.es
Szczypiorska
Magdalena
M
Juanola
Xavier
X
Bartolomé
Nerea
N
Gratacós
Jordi
J
Zarco
Pedro
P
Collantes
Eduardo
E
Artieda
Marta
M
Martínez
Antonio
A
Tejedor
Diego
D
Mulero
Juan
J
D000328:Adult; D000483:Alleles; D021901:DNA, Intergenic / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012042:Registries; D013030:Spain; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D021901:DNA, Intergenic