[Arthritis of the atlanto-axial joint with inflammatory neck pain as a primary manifestation of seronegative rheumatoid arthritis].
METHODS
A 68-year-old woman with known degenerative joint disease suffered from increasing neck pain. Physical examination revealed painfully restricted movement of the cervical spine.


METHODS
Erythrocyte sedimentation rate and C-reactive protein were increased. Tests for rheumatoid factors, antinuclear, anti-citrullinated protein and anti-neutrophil cytoplasmic antibody were negative. Cervical spine x-ray showed osteochondrosis with partially bridging spondylosis at C5/C6, but there was no atlanto-axial dislocation. Magnetic resonance imaging (MRI) revealed bone marrow edema and hyperintensity of the odontoid process, but there were no indications of fissures or fracture lines.


METHODS
These findings indicated seronegative rheumatoid arthritis, with predominantly active atlanto-axial arthritis. After methotrexate and prednisolone had been administered the symptoms improved rapidly and inflammatory parameters returned to normal. Three months later no atlanto-axial arthritis was seen at MRI.


CONCLUSIONS
Rheumatoid arthritis involving the atlanto-axial region should be considered in patients with persisting neck pain and signs of inflammation.
Haeusler
U
U
Rheumazentrum Ruhrgebiet, St. Vinzenz Gruppe Ruhr GmbH.
Dybowski
F
F
Wittkaemper
T A
TA
Kisters
K
K
Godolias
G
G
Braun
J
J
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy; D001268:Atlanto-Axial Joint; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D019547:Neck Pain / Q000175:diagnosis* / Q000209:etiology; D010003:Osteoarthritis / Q000150:complications; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D011239:Prednisolone; D008727:Methotrexate