Matrix remodeling in vascular calcification associated with chronic kidney disease.
Vascular calcification is a major contributor to cardiovascular disease, a leading cause of death in patients with chronic kidney disease. Mechanistic studies highlight the importance of dysregulated mineral metabolism, vascular osteochondrogenic processes, apoptosis, and deficiencies in calcification inhibitors as potential mediators of calcification in renal disease. However, the contribution of the extracellular matrix in vascular calcification associated with chronic kidney disease is less understood. Here we examine evidence that suggests important roles for elastin and elastin-degrading enzymes as potential key regulators of calcification. Additional studies aimed at further understanding their role are critical for the design of therapeutic interventions.
Pai
Ashwini S
AS
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Giachelli
Cecilia M
CM
D000818:Animals; D002114:Calcinosis / Q000150:complications / Q000378:metabolism*; D004549:Elastin / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*; D014652:Vascular Diseases / Q000150:complications / Q000378:metabolism*
D004549:Elastin; D020782:Matrix Metalloproteinases