Evaluation of synthesized cross linked polyvinyl alcohol as potential disintegrant.
OBJECTIVE
The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant.


METHODS
Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of the disintegrant (including sedimentation volume, hydration capacity, specific surface area and bulk and tap density) were determined and compared to the known disintegrants. Characterization was carried out using FT-IR, DSC, XRD, SEM and Photo microscopy studies. The developed excipient was also studied for acute toxicity in rats and found to be safe for oral use.


RESULTS
Disintegration property of formed product was compared to known disintegrant (Ac-Di-Sol) and it was found to give better results. The disintegration mechanism of developed disintegrant was postulated based on results obtained from various physical evaluations including: Study of effect of disintegrant concentration, fillers, and hardness, mode of incorporation and method of granulation on disintegration activity.


CONCLUSIONS
By changing the condition parameters of well known crosslinking reaction of PVA, we obtained a crosslinked product which had excellent disintegration activity, good flow and optimal tableting properties.
Patel
Ashok R
AR
Centre for Novel Drug Delivery Systems, Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Matunga, Mumbai 400019, India. ashok2510@gmail.com
Vavia
Pradeep R
PR
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003432:Cross-Linking Reagents; D005079:Excipients / Q000737:chemistry* / Q000633:toxicity; D005976:Glutaral / Q000737:chemistry; D008297:Male; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D013696:Temperature; D013997:Time Factors; D023382:Toxicity Tests, Acute
D003432:Cross-Linking Reagents; D005079:Excipients; D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium; D005976:Glutaral