Stressing the role of O-GlcNAc: linking cell survival to keratin modification.
Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.
Rotty
Jeremy D
JD
Hart
Gerald W
GW
Coulombe
Pierre A
PA
D000117:Acetylglucosamine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D002470:Cell Survival / Q000502:physiology; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D053538:Keratin-18 / Q000235:genetics / Q000378:metabolism; D053533:Keratin-8 / Q000378:metabolism; D007633:Keratins / Q000378:metabolism*; D008954:Models, Biological; D010091:Oximes / Q000494:pharmacology; D048448:Phenylcarbamates / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D013311:Streptozocin / Q000494:pharmacology; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D019014:fas Receptor / Q000819:agonists
D053538:Keratin-18; D053533:Keratin-8; D010091:Oximes; D048448:Phenylcarbamates; D019014:fas Receptor; C068836:N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime; D013311:Streptozocin; D007633:Keratins; C514862:Akt1 protein, mouse; D051057:Proto-Oncogene Proteins c-akt; C110628:hexosaminidase C; D001619:beta-N-Acetylhexosaminidases; D000117:Acetylglucosamine
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