Fluid and solid mechanics in a poroelastic network induced by ultrasound.
We made a theoretical analysis on the fluid and solid mechanics in a poroelastic medium induced by low-power ultrasound. Using a perturbative approach, we were able to linearize the governing equations and obtain analytical solutions. We found that ultrasound could propagate in the medium as a mechanical wave, but would dissipate due to frictional forces between the fluid and the solid phase. The amplitude of the wave depends on the ultrasonic power input. We applied this model to the problem of drug delivery to soft biological tissues by low-power ultrasound and proposed a mechanism for enhanced drug penetration. We have also found the coexistence of two acoustic waves under certain circumstances and pointed out the importance of very accurate experimental determination of the high-frequency properties of brain tissue.
Wang
Peng
P
School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853, USA. pw96@cornell.edu
Olbricht
William L
WL
D001696:Biomechanical Phenomena; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D016503:Drug Delivery Systems; D004548:Elasticity; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D016062:Porosity; D014464:Ultrasonic Therapy; D014465:Ultrasonics