Evidence for impaired vagus nerve activity in heart failure.
Parasympathetic control of the heart via the vagus nerve is the primary mechanism that regulates beat-to-beat control of heart rate. Additionally, the vagus nerve exerts significant effects at the AV node, as well as effects on both atrial and ventricular myocardium. Vagal control is abnormal in heart failure, occurring at early stages of left ventricular dysfunction, and this reduced vagal function is associated with worse outcomes in patients following myocardial infarction and with heart failure. While central control mechanisms are abnormal, one of the primary sites of attenuated vagal control is at the level of the parasympathetic ganglion. It remains to be seen whether or not preventing or treating abnormal vagal control of the heart improves prognosis.
Bibevski
Steve
S
Department of Cardiothoracic Surgery, University of Michigan Cardiovascular Center, 5144 Cardiovascular Center, 1500 E. Medical Center Drive SPC 5864, Ann Arbor, MI 48109, USA.
Dunlap
Mark E
ME
D005726:Ganglia, Parasympathetic; D006333:Heart Failure / Q000473:pathology*; D006801:Humans; D010275:Parasympathetic Nervous System / Q000503:physiopathology*; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D014630:Vagus Nerve / Q000503:physiopathology*
D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic
J Neurosci. 1999 Nov 1;19(21):9298-305
10531434
J Auton Nerv Syst. 1996 Feb 5;57(1-2):123-7
8867095
Circ J. 2005 Apr;69(4):493-9
15791049
Circulation. 1992 Apr;85(4):1311-7
1555275
J Auton Nerv Syst. 1987 Jul;20(1):13-23
3655182
Am J Cardiol. 1997 Dec 4;80(11A):7L-14L
9412538
Prog Cardiovasc Dis. 1995 Sep-Oct;38(2):155-66
7568904
Br J Pharmacol. 1982 Jan;75(1):9-11
7074289
Brain Res. 1993 Jul 23;617(2):349-52
8402163
Am J Physiol. 1992 May;262(5 Pt 2):H1401-6
1590444
Annu Rev Physiol. 1995;57:521-46
7778876
J Physiol. 2000 Nov 1;528(Pt 3):561-71
11060132
Heart Fail Rev. 2003 Jan;8(1):35-46
12652158
Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2516-22
17644572
Trends Pharmacol Sci. 1990 Jun;11(6):216-9
2200178
Am J Physiol Heart Circ Physiol. 2002 Jan;282(1):H363-71
11748083
Am J Physiol Heart Circ Physiol. 2003 Oct;285(4):H1632-40
12829433
J Cardiovasc Pharmacol. 1998 Jun;31(6):937-44
9641480
Circ Heart Fail. 2009 Nov;2(6):692-9
19919995
J Am Coll Cardiol. 2008 Oct 21;52(17):1353-65
18940523
Am J Cardiol. 1987 Feb 1;59(4):256-62
3812275
Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1212-23
12893651
Am J Physiol. 1988 Nov;255(5 Pt 2):R703-8
2461101
J Cardiovasc Pharmacol. 2003 Jul;42(1):125-31
12827037
Clin Exp Pharmacol Physiol Suppl. 1982;7:51-5
6958401
Circulation. 1996 Jul 1;94(1):102-7
8964109
Am J Physiol. 1990 Nov;259(5 Pt 2):H1504-10
1978577
Am J Physiol. 1990 May;258(5 Pt 2):H1470-5
2337181
Circulation. 2004 Aug 10;110(6):713-7
15289373
Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1066-75
12842863
J Card Fail. 2003 Oct;9(5):354-63
14583895
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1780-5
15191889
J Auton Nerv Syst. 1998 May 28;70(1-2):129-41
9686913
J Am Coll Cardiol. 1993 Mar 1;21(3):655-61
8436747
Curr Heart Fail Rep. 2009 Jun;6(2):71-80
19486590
Lancet. 1998 Feb 14;351(9101):478-84
9482439
Exp Physiol. 2009 Jan;94(1):46-53
18945757
Circulation. 2007 Aug 21;116(8):954-60
17709650
Cardiol Rev. 2009 Nov-Dec;17(6):287-92
19829179
Am J Physiol. 1990 Apr;258(4 Pt 2):H1112-8
2330999
Biophys J. 2008 Feb 15;94(4):1144-54
17921202
Am J Physiol. 1995 Feb;268(2):R310-16
7864224
Circulation. 1999 Jun 8;99(22):2958-63
10359742
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5746-51
10318955
Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1729-35
15923309
News Physiol Sci. 2002 Oct;17:202-6
12270957
J Auton Nerv Syst. 1989 Feb;26(1):27-36
2708782
Circulation. 1992 Jan;85(1 Suppl):I77-91
1728509
J Neurosci. 2000 Jul 1;20(13):5076-82
10864965
Circulation. 2008 Aug 19;118(8):863-71
18711023
J Am Coll Cardiol. 1991 Aug;18(2):464-72
1856414
N Engl J Med. 1971 Oct 14;285(16):877-83
4398792
Am J Physiol. 1973 Jan;224(1):202-8
4683302
Am J Physiol. 1986 Oct;251(4 Pt 2):H764-73
3021001
Auton Neurosci. 2002 Jan 10;95(1-2):71-9
11873770
Curr Med Res Opin. 2005 Jul;21(7):1115-22
16004681