title: Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads.
abstract: Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with superparamagnetic iron oxide nanoparticles and the anti-cancer drug doxorubicin. The drug-containing particles are delivered to human cervical cancer (HeLa) cells in vitro, under the guidance of a magnetic field. The high concentration of particles in the proximity of the magnetic field results in a high concentration of drug being released in that region of the Petri dish, and localized cell death is confirmed by cellular viability assay (Calcein AM).
authors.affiliation: Department of Chemistry and Biochemistry, Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman, La Jolla, CA 92093, USA.
authors.forename: Luo
authors.initials: L
authors.lastname: Gu
authors.forename: Ji-Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Kim H
authors.initials: KH
authors.lastname: Duong
authors.forename: Erkki
authors.initials: E
authors.lastname: Ruoslahti
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sailor
mesh_terms: D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012825:Silicon / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin; D012825:Silicon
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