title: Feasibility of FAIR imaging for evaluating tumor perfusion.
abstract: OBJECTIVE
  To evaluate the feasibility of flow-sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models.
  
  
  METHODS
  In eight mice tumor models, FAIR and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE-MR images. The correlation between the blood flow on FAIR and perfusion-related parameters on DCE-MRI was evaluated using the Pearson correlation coefficient.
  
  
  RESULTS
  The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec(-) (1)) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01).
  
  
  CONCLUSIONS
  As blood flow measurement on FAIR is reliable and closely related with that on DCE-MR, FAIR is feasible for measuring tumor blood flow.
authors.affiliation: Division of Magnetic Resonance, Korea Basic Science Institute, Chungbuk, Korea.
authors.forename: Jee-Hyun
authors.initials: JH
authors.lastname: Cho
authors.forename: Gyunggoo
authors.initials: G
authors.lastname: Cho
authors.forename: Youngkyu
authors.initials: Y
authors.lastname: Song
authors.forename: Chulhyun
authors.initials: C
authors.lastname: Lee
authors.forename: Bum-Woo
authors.initials: BW
authors.lastname: Park
authors.forename: Chang Kyung
authors.initials: CK
authors.lastname: Lee
authors.forename: Namkug
authors.initials: N
authors.lastname: Kim
authors.forename: Sung Bin
authors.initials: SB
authors.lastname: Park
authors.forename: Jong Soon
authors.initials: JS
authors.lastname: Kang
authors.forename: Moo Rim
authors.initials: MR
authors.lastname: Kang
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
authors.forename: Young Ro
authors.initials: YR
authors.lastname: Kim
authors.forename: Kyoung-Sik
authors.initials: KS
authors.lastname: Cho
authors.forename: Jeong Kon
authors.initials: JK
authors.lastname: Kim
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D003287:Contrast Media; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA; D007089:Image Enhancement; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D010477:Perfusion; D016658:Psoas Muscles / Q000098:blood supply; D011897:Random Allocation; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D015203:Reproducibility of Results; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels; D019786:Gadolinium DTPA