title: Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka (Oryzias latipes).
abstract: Glucocorticoid metabolites enter the aquatic environment via mammalian excrements. Molecular structures of their C19O3 metabolites strongly resemble the major fish androgen 11-ketotestosterone. Therefore, we tested the hypothesis that the cortisol metabolite 5alpha-androstan-3,11,17-trione acts similarly to 11-ketotestosterone by employing a fish screening assay for endocrine-active substances. After 21 d, both 11-oxygenated compounds had masculinized sex characteristics of the anal fin in female medaka in a dose-dependent manner.
authors.affiliation: Aquatic Ecotoxicology, Department of Biomedical Sciences, University of Veterinary Medicine, Veterinaerplatz 1, A-1210 Vienna, Austria. britta.grillitsch@vetmeduni.ac.at
authors.forename: Britta
authors.initials: B
authors.lastname: Grillitsch
authors.forename: Dominik
authors.initials: D
authors.lastname: Altmann
authors.forename: Michael
authors.initials: M
authors.lastname: Schabuss
authors.forename: Horst
authors.initials: H
authors.lastname: Zornig
authors.forename: Irene
authors.initials: I
authors.lastname: Sommerfeld-Stur
authors.forename: Erich
authors.initials: E
authors.lastname: Möstl
mesh_terms: D000728:Androgens / Q000633:toxicity*; D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D005938:Glucocorticoids / Q000378:metabolism*; D009990:Oryzias / Q000502:physiology*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000728:Androgens; D052244:Endocrine Disruptors; D005938:Glucocorticoids; D014874:Water Pollutants, Chemical