title: Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.
abstract: A palladium-catalyzed addition of arylboronic acids to phthalaldehyde, followed by an intramolecular lactonization to access 3-substituted phthalides, is described. The procedure tolerates a series of functional groups, such as methoxyl, fluoro, chloro, and trifluoromethyl groups. It represents a procedure for the synthesis of 3-substituted phthalides.
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, People's Republic of China.
authors.forename: Zhishi
authors.initials: Z
authors.lastname: Ye
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Qian
authors.forename: Guanglei
authors.initials: G
authors.lastname: Lv
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.forename: Jiang
authors.initials: J
authors.lastname: Cheng
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D009764:o-Phthalaldehyde / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D001897:Boronic Acids; D007783:Lactones; D010165:Palladium; D009764:o-Phthalaldehyde; C082022:phthalide