title: Rhabdomyolysis induced by rosuvastatin and sildenafil.
abstract: A 66-year-old man with diabetes and hypertension using statin was admitted to the hospital with progressive myalgia. He had been on rosuvastatin for five months. After beginning the use of phosphodiesterase-5 inhibitors, he presented with severe muscle pain and maintained penile erection. Several days after interruption of therapy, muscle pain and penile erection disappeared. This case demonstrates the interaction of sildenafil with rosuvastatin might result in myopathy.
authors.affiliation: Department of Neurosciences, University of Catania, Catania, Italy; and Department of Senescence, Urological, and Neurological Sciences, University of Catania, Catania, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pennisi
authors.forename: Marco
authors.initials: M
authors.lastname: Vacante
authors.forename: Cristina
authors.initials: C
authors.lastname: Russo
authors.forename: Mariano
authors.initials: M
authors.lastname: Malaguarnera
mesh_terms: D000368:Aged; D004347:Drug Interactions; D005464:Fluorobenzenes / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D010146:Pain / Q000139:chemically induced; D010410:Penile Erection / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D011687:Purines / Q000009:adverse effects; D011743:Pyrimidines / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D000068718:Rosuvastatin Calcium; D000068677:Sildenafil Citrate; D013449:Sulfonamides / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects*
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D013449:Sulfonamides; D013450:Sulfones; D000068718:Rosuvastatin Calcium; D000068677:Sildenafil Citrate