Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles.
1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.
Kwok
Sen W
SW
The Scripps Research Institute, La Jolla, California 92037, USA.
Fotsing
Joseph R
JR
Fraser
Rebecca J
RJ
Rodionov
Valentin O
VO
Fokin
Valery V
VV
D002384:Catalysis; D006878:Hydroxides / Q000737:chemistry; D015394:Molecular Structure; D028561:Transition Elements / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis*
D006878:Hydroxides; D028561:Transition Elements; D014230:Triazoles
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