Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive PECE hydrogel.
BACKGROUND
Post-operative peritoneal adhesions are common and serious complications for modern medicine. We aim to prevent post-surgical adhesions using biodegradable and thermosensitive poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) hydrogel. In this work, we investigated the effect of PECE hydrogel on preventing post-surgical abdominal adhesions in mouse and rat models.


RESULTS
The PECE hydrogel in sol state could be transformed into gel in less than 20 s at 37°C. In addition, the PECE hydrogel could be easily adhered to the damaged peritoneal surfaces, and be gradually degraded and absorbed by the body within 14 days along with the healing of peritoneal wounds. A notable efficacy of the PECE hydrogel in preventing peritoneal adhesions was demonstrated in the animal models. In contrast, all untreated animals developed adhesions requiring sharp dissection. Furthermore, no significant histopathological changes were observed in main organs of the hydrogel-treated animals.


CONCLUSIONS
Our results suggested that the thermosensitive PECE hydrogel was an effective, safe, and convenient agent on preventing post-surgical intro-abdominal adhesions.
Yang
Bing
B
Department of Gynecology and Obstetrics, Second West China Hospital, and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
Gong
ChangYang
C
Qian
ZhiYong
Z
Zhao
Xia
X
Li
ZhengYu
Z
Qi
XiaoRong
X
Zhou
ShengTao
S
Zhong
Qian
Q
Luo
Feng
F
Wei
YuQuan
Y
D000005:Abdomen / Q000601:surgery; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002432:Cecum / Q000293:injuries; D005260:Female; D020100:Hydrogels / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D010537:Peritoneum / Q000293:injuries; D011091:Polyesters / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control*; D014945:Wound Healing
D001672:Biocompatible Materials; D020100:Hydrogels; D011091:Polyesters; C502908:poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol); D011092:Polyethylene Glycols
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