Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 μM. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors.
Jiang
He Zhong
HZ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Quan
Xiao Fang
XF
Tian
Wei Xi
WX
Hu
Jiang Miao
JM
Wang
Peng Cheng
PC
Huang
Sheng Zhuo
SZ
Cheng
Zhong Quan
ZQ
Liang
Wen Juan
WJ
Zhou
Jun
J
Ma
Xiao Feng
XF
Zhao
You Xing
YX
D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002645:Chickens; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D029762:Garcinia mangostana / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D001577:Benzophenones; D004791:Enzyme Inhibitors; D010636:Phenols; D044004:Xanthones; D064429:Fatty Acid Synthases