[L-type calcium channel blockers support energy metabolism in rabbit cardiomyocytes exposed to general vibration].
The aim of the paper was to study the mechanism of vibroprotective action of nifedipine, a blocker of L-type calcium channels, on cardiomyocytes of a rabbit. The enegry-dependent reactions of native mitochondria of rabbit myocardium were studied by polarographic method using Clark's type close membrane electrode. The changes in functional activity of mitochondria like low energy shift with activation of succinate oxidation and inhibition of NAD-depended chain of mitochondria breath were observed after prolong common vibration within 56 days. Nifedipine 7.5 mg/kg orally activated NAD-dependent site of cell breath and reduced hyperactivation of succinate-dependent breath by means of down-up mechanism. The positive energotropic effect of nifedipine was accompanied with retention of hystomorphological architecture of the myocardium. Therefore, nifedipine defends energy metabolism in the myocardium in chronic exposure of common vibration.
Vorob'eva
V V
VV
Shabanov
P D
PD
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000502:physiology*; D042967:Electron Transport Complex I / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011817:Rabbits; D019802:Succinic Acid / Q000378:metabolism; D013997:Time Factors; D014732:Vibration / Q000009:adverse effects*
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D019802:Succinic Acid; D042967:Electron Transport Complex I; D009543:Nifedipine