The avian proghrelin system.
To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure and function of the components that comprise this system. These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different tissues. Also key to the functioning of this system is the posttranslational processing of the proghrelin precursor protein and the individual peptides derived from it. While this system has been intensively studied in a variety of animal species and humans over the last decade, there has been considerably less investigation of the avian proghrelin system which exhibits some unique differences compared to mammals. This review summarizes what is currently known about the proghrelin system in birds and offers new insights into the nature and function of this important endocrine system. Such information facilitates cross-species comparisons and contributes to our understanding of the evolution of the proghrelin system.
Richards
Mark P
MP
United States Department of Agriculture, Agricultural Research Service, Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Animal and Natural Resources Institute, Beltsville, MD 20705-2350, USA.
McMurtry
John P
JP
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6320-5
18443287
Peptides. 2007 Mar;28(3):617-24
17145117
Gen Comp Endocrinol. 2005 Apr;141(2):178-83
15748719
Nat Med. 2009 Jul;15(7):741-5
19503064
Eur J Pharmacol. 2002 Oct 18;453(1):75-9
12393062
Domest Anim Endocrinol. 2006 Feb;30(2):108-16
16054797
Peptides. 2008 Jul;29(7):1255-70
18396350
Peptides. 2009 Jul;30(7):1342-7
19409434
Endocrinology. 2001 Sep;142(9):4154-7
11517195
Endocrinology. 2004 Sep;145(9):4144-53
15142980
Neurosci Lett. 2006 Sep 25;405(3):241-5
16901639
Endocrinology. 2002 Sep;143(9):3454-63
12193558
Life Sci. 2004 Sep 17;75(18):2193-201
15325845
Vet Res Commun. 2004 Aug;28 Suppl 1:213-5
15372960
Nature. 1999 Dec 9;402(6762):656-60
10604470
Comp Biochem Physiol A Mol Integr Physiol. 2008 Feb;149(2):109-28
18222718
J Biol Chem. 2003 Jan 3;278(1):64-70
12414809
J Biol Chem. 2000 Jul 21;275(29):21995-2000
10801861
Regul Pept. 2009 Apr 10;154(1-3):97-101
19232371
Growth Dev Aging. 2004 Summer;68(1):3-10
15307660
Domest Anim Endocrinol. 2007 Apr;32(3):216-25
16766157
Regul Pept. 2003 Mar 28;111(1-3):123-8
12609759
Science. 1996 Aug 16;273(5277):974-7
8688086
Gen Comp Endocrinol. 2008 Apr 1;156(2):323-38
18299131
Gen Comp Endocrinol. 2009 Sep 1;163(1-2):39-46
18938167
Science. 2005 Nov 11;310(5750):996-9
16284174
Comp Biochem Physiol A Mol Integr Physiol. 2007 May;147(1):239-46
17293148
J Biol Chem. 2006 Dec 15;281(50):38867-70
17050541
Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147(4):893-902
17376723
Biochem Genet. 2007 Apr;45(3-4):185-94
17347866
Physiol Rev. 2005 Apr;85(2):495-522
15788704
Acta Histochem. 2005;107(1):3-9
15866281
Biochem Biophys Res Commun. 2005 Jul 29;333(2):583-9
15953586
Br Poult Sci. 2004 Oct;45(5):611-8
15623213
Gen Comp Endocrinol. 2006 Feb;145(3):298-310
16253250
BMC Genomics. 2007 Aug 30;8:298
17727735
Domest Anim Endocrinol. 2008 Feb;34(2):125-34
17207955
Gen Comp Endocrinol. 2009 Sep 1;163(1-2):33-8
19056391
Gen Comp Endocrinol. 2003 Nov;134(2):167-74
14511987
Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar;149(3):325-9
18280762
Mol Cell Endocrinol. 2006 Sep 26;257-258:15-25
16891055
Poult Sci. 2007 Nov;86(11):2472-6
17954600
Gen Comp Endocrinol. 2003 Nov;134(2):198-202
14511992
Mol Biol Rep. 2010 Jan;37(1):423-8
19437137
Neurobiol Learn Mem. 2009 May;91(4):402-7
19146965
J Endocrinol. 2003 Oct;179(1):97-105
14529570
Peptides. 2009 May;30(5):991-4
19428778
Gen Comp Endocrinol. 2007 Mar;151(1):128-34
17239877
Neurosci Lett. 2001 Mar 30;301(2):123-6
11248438
J Biochem. 2009 Nov;146(5):675-82
19628676
Trends Endocrinol Metab. 2008 Dec;19(10):362-70
18938086
Regul Pept. 2005 Feb 15;125(1-3):201-8
15582733
Domest Anim Endocrinol. 2007 May;32(4):247-59
16650710
Cell. 2008 Feb 8;132(3):387-96
18267071
Biochem Biophys Res Commun. 2003 May 23;305(1):186-92
12732215
J Endocrinol. 2002 Jan;172(1):117-25
11786379