[Effect of Ruiqi tablet on mitochondrion activities in cerebral cortex neurons of fetal rats].
OBJECTIVE
To explore the effect of Ruiqi tablet on mitochondrion activities in the cerebral cortex neurons of fetal mice.


METHODS
The cerebral cortex of fetal Wistar rats after 16- 17 gestation days were collected and randomized into Ruiqi tablet group and blank control group after 4-5 days' culture. Laser scanning confocal microscope was adopted to determine the changes in the mitochondrion activities of the primary cultured cerebral cortex neurons of fetal rats after addition of Ruiqi tablet solution.


RESULTS
Ruiqi tablet can increase the mitochondrion activities of the cerebral cortex neurons. No significant change in the mitochondrion activities of the cerebral cortex neurons was found in the blank control group.


CONCLUSIONS
Ruiqi tablet can increase the mitochondrion activities of the neurons and it has certain application prospects in treatment of some neurodegenerative diseases such as Alzheimer's disease, vascular dementia, Parkinson's disease and so on.
Zhou
Peiyun
P
Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091, China.
Ge
Wenjin
W
Li
Duanwu
D
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000737:chemistry / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D023421:Models, Animal; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
D004365:Drugs, Chinese Herbal; D013607:Tablets