title: Prolonged gonadotropin stimulation is associated with decreased ART success.
abstract: OBJECTIVE
  to evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART.
  
  
  METHODS
  all IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed.
  
  
  RESULTS
  out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10-12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30-0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis.
  
  
  CONCLUSIONS
  prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Meleen
authors.initials: M
authors.lastname: Chuang
authors.forename: Athena
authors.initials: A
authors.lastname: Zapantis
authors.forename: Martina
authors.initials: M
authors.lastname: Taylor
authors.forename: Sangita K
authors.initials: SK
authors.lastname: Jindal
authors.forename: Genevieve S
authors.initials: GS
authors.lastname: Neal-Perry
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Lieman
authors.forename: Alex Joel
authors.initials: AJ
authors.lastname: Polotsky
mesh_terms: D000328:Adult; D001723:Birth Rate; D015331:Cohort Studies; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007246:Infertility / Q000628:therapy*; D050498:Live Birth; D016015:Logistic Models; D015999:Multivariate Analysis; D054315:Oocyte Retrieval; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone
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