Language in schizophrenia Part 2: What can psycholinguistics bring to the study of schizophrenia...and vice versa?
This is the second of two articles that discuss higher-order language and semantic processing in schizophrenia. The companion article (Part 1) gives an introduction to language dysfunction in schizophrenia patients. This article reviews a selection of psycholinguistic studies which suggest that sentence-level abnormalities in schizophrenia may stem from a relative overdependence on semantic associative relationships at the expense of building higher-order meaning. Language disturbances in schizophrenia may be best conceptualized as arising from an imbalance of activity across two streams of processing, one drawing upon semantic relationships within semantic memory and the other involving the use of combinatorial mechanisms to build propositional meaning. I will also discuss some of the ways in which the study of schizophrenia may offer new insights into the cognitive and neural architecture of the normal language system.
Kuperberg
Gina R
GR
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA.
Brain Lang. 2007 Mar;100(3):223-37
16546247
Am J Psychiatry. 1997 May;154(5):640-6
9137119
J Neurolinguistics. 2010 May 1;23(3):254-269
20383285
J Cogn Neurosci. 2011 May;23(5):1230-46
20175676
Neuropsychology. 2006 Jul;20(4):442-52
16846262
Schizophr Res. 1996 May;20(1-2):1-13
8794488
Mem Cognit. 2005 Oct;33(7):1174-84
16532852
Psychol Sci. 2008 Dec;19(12):1213-8
19121125
Psychophysiology. 2007 Jul;44(4):491-505
17521377
Neuroreport. 2001 Oct 29;12(15):3391-4
11711892
Psychol Rev. 1994 Oct;101(4):676-703
7984711
Trends Cogn Sci. 2002 Aug 1;6(8):350-356
12140086
J Exp Psychol Learn Mem Cogn. 1989 Mar;15(2):326-38
2522518
Biol Psychol. 1991 Oct-Dec;32(2-3):101-24
1790265
Biol Psychiatry. 2008 Sep 1;64(5):407-18
18504037
Neuroimage. 2006 May 1;30(4):1414-32
16413796
Psychol Rev. 1988 Apr;95(2):163-82
3375398
Behav Brain Sci. 1999 Feb;22(1):77-94; discussion 95-126
11301522
J Abnorm Psychol. 2009 May;118(2):256-77
19413402
Brain Res. 2006 Nov 6;1118(1):155-67
16956594
J Cogn Neurosci. 2000 Jul;12(4):556-68
10936910
Science. 2004 Apr 16;304(5669):438-41
15031438
Prog Exp Pers Res. 1964;72:49-77
14348124
Psychophysiology. 1999 Sep;36(5):559-70
10442024
J Cogn Neurosci. 2008 Apr;20(4):580-91
18052777
J Abnorm Psychol. 2000 Nov;109(4):761-7
11196002
Schizophr Res. 1993 Oct;10(3):247-57
8260443
Psychol Rev. 2001 Oct;108(4):759-88
11699116
Brain Res. 2007 May 18;1146:23-49
17400197
Psychiatry Res. 2007 Apr 15;154(3):221-32
17360163
J Abnorm Psychol. 2006 May;115(2):251-65
16737390
Brain Lang. 2007 Mar;100(3):257-61
16919324
J Abnorm Psychol. 2002 May;111(2):313-20
12003452
Schizophr Res. 1999 Nov 30;40(2):159-70
10593455
Behav Brain Sci. 2003 Dec;26(6):651-65; discussion 666-707
15377127
Cogn Psychol. 2003 Sep;47(2):164-203
12948517
Psychophysiology. 2007 Nov;44(6):991-1001
17666031
J Exp Psychol Learn Mem Cogn. 2005 May;31(3):443-67
15910130
J Abnorm Psychol. 1997 Feb;106(1):85-94
9103720
Mem Cognit. 1996 Nov;24(6):733-43
8961818
Psychol Med. 2000 Mar;30(2):345-57
10824655
Brain Res Cogn Brain Res. 2003 Jun;17(1):117-29
12763198
Biol Psychiatry. 1993 Oct 1;34(7):443-58
8268329
Int J Psychophysiol. 2010 Feb;75(2):66-76
19765622
Psychol Rev. 1992 Jan;99(1):122-49
1546114
Br J Psychiatry. 2003 May;182:381-4
12724239
Schizophr Bull. 2002;28(3):475-90
12645679
Nat Neurosci. 2005 Aug;8(8):1117-21
16007080
J Abnorm Psychol. 1998 Aug;107(3):423-34
9715577
Biol Psychiatry. 2002 Mar 15;51(6):485-92
11922884
Arch Gen Psychiatry. 2003 Sep;60(9):878-88
12963669
J Cogn Neurosci. 2008 Nov;20(11):2037-57
18416681
Brain Res Brain Res Rev. 2000 Mar;31(2-3):118-29
10719140
Trends Cogn Sci. 2000 Dec 1;4(12):463-470
11115760
Schizophr Res. 1998 Mar 10;30(2):115-25
9549774
Brain Res Cogn Brain Res. 2004 Mar;19(1):59-73
14972359
Psychophysiology. 2002 Nov;39(6):851-60
12462512
Schizophr Res. 2003 Nov 15;64(2-3):147-56
14613679
Arch Gen Psychiatry. 2007 Feb;64(2):138-51
17283282
Schizophr Res. 2003 Apr 1;60(2-3):299-309
12591591