title: Anterior insula activity predicts the influence of positively framed messages on decision making.
abstract: The neural mechanisms underlying the influence of persuasive messages on decision making are largely unknown. We address this issue using event-related fMRI to investigate how informative messages alter risk appraisal during choice. Participants performed the Iowa Gambling Task while viewing a positively framed, negatively framed, or control message about the options. The right anterior insula correlated with improvement in choice behavior due to the positively framed but not the negatively framed message. With the positively framed message, there was increased activation proportional to message effectiveness when less-preferred options were chosen, consistent with a role in the prediction of adverse outcomes. In addition, the dorsomedial and the left dorsolateral prefrontal cortex correlated with overall decision quality, regardless of message type. The dorsomedial region mediated the relationship between the right anterior insula and decision quality with the positively framed messages. These findings suggest a network of frontal brain regions that integrate informative messages into the evaluation of options during decision making. Supplemental procedures and results for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.
authors.affiliation: Indiana University, Bloomington, Indiana, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Krawitz
authors.forename: Rena
authors.initials: R
authors.lastname: Fukunaga
authors.forename: Joshua W
authors.initials: JW
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005715:Gambling / Q000523:psychology; D005717:Games, Experimental; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010565:Persuasive Communication; D018570:Risk Assessment; D012309:Risk-Taking; D035501:Uncertainty; D055815:Young Adult
references.citation: Cereb Cortex. 2009 May;19(5):1134-43
references.pmid: 18787233
references.citation: Neuroimage. 2005 Jan 1;24(1):253-9
references.pmid: 15588617
references.citation: Cogn Affect Behav Neurosci. 2007 Dec;7(4):266-77
references.pmid: 18189000
references.citation: Science. 2000 Jun 9;288(5472):1835-8
references.pmid: 10846167
references.citation: Neurosci Biobehav Rev. 2006;30(2):239-71
references.pmid: 16197997
references.citation: Neuron. 2008 Sep 25;59(6):1037-50
references.pmid: 18817740
references.citation: Soc Cogn Affect Neurosci. 2008 Dec;3(4):353-66
references.pmid: 19015077
references.citation: J Health Commun. 2007 Oct-Nov;12(7):623-44
references.pmid: 17934940
references.citation: Neuroimage. 2009 May 15;46(1):87-104
references.pmid: 19457397
references.citation: Psychol Sci. 2000 Jan;11(1):1-6
references.pmid: 11228836
references.citation: Hum Brain Mapp. 2006 Jul;27(7):572-87
references.pmid: 16372256
references.citation: Nicotine Tob Res. 2008 Jan;10(1):195-200
references.pmid: 18188760
references.citation: Nat Rev Neurosci. 2002 Aug;3(8):655-66
references.pmid: 12154366
references.citation: Psychon Bull Rev. 1994 Dec;1(4):476-90
references.pmid: 24203555
references.citation: Science. 1997 Feb 28;275(5304):1293-5
references.pmid: 9036851
references.citation: Neuroimage. 2007 Feb 15;34(4):1744-53
references.pmid: 17175173
references.citation: Psychol Bull. 2001 Mar;127(2):267-86
references.pmid: 11316014
references.citation: Psychol Bull. 1997 Jan;121(1):3-19
references.pmid: 9000890
references.citation: Hum Brain Mapp. 2000 Jul;10(3):120-31
references.pmid: 10912591
references.citation: Behav Brain Funct. 2007 Mar 15;3:16
references.pmid: 17362508
references.citation: J Neurosci. 2006 May 3;26(18):4769-73
references.pmid: 16672649
references.citation: Neuropsychologia. 2001;39(4):376-89
references.pmid: 11164876
references.citation: Behav Brain Funct. 2007 Aug 06;3:37
references.pmid: 17683599
references.citation: Neuron. 2005 Sep 1;47(5):763-70
references.pmid: 16129404
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: J Comp Neurol. 1989 Aug 15;286(3):353-75
references.pmid: 2768563
references.citation: Perspect Psychol Sci. 2009 May;4(3):299-307
references.pmid: 26158967
references.citation: Health Psychol. 2004 May;23(3):330-4
references.pmid: 15099176
references.citation: Neuron. 2004 Oct 14;44(2):379-87
references.pmid: 15473974
references.citation: J Pers Soc Psychol. 1986 Dec;51(6):1173-82
references.pmid: 3806354
references.citation: J Neurosci. 2008 Mar 12;28(11):2745-52
references.pmid: 18337404
references.citation: Brain Res. 2008 Apr 2;1202:99-108
references.pmid: 17707352
references.citation: Nat Neurosci. 2007 Sep;10(9):1214-21
references.pmid: 17676057
references.citation: Cognition. 1994 Apr-Jun;50(1-3):7-15
references.pmid: 8039375
references.citation: Behav Brain Funct. 2008 Mar 19;4:13
references.pmid: 18353176
references.citation: Psychol Methods. 2001 Jun;6(2):115-34
references.pmid: 11411437
references.citation: Science. 2005 Feb 18;307(5712):1118-21
references.pmid: 15718473
references.citation: Neuroimage. 2006 Apr 1;30(2):668-77
references.pmid: 16321546
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Hum Brain Mapp. 1999;8(2-3):109-14
references.pmid: 10524601
references.citation: Neuron. 2006 Aug 3;51(3):381-90
references.pmid: 16880132
references.citation: Front Behav Neurosci. 2009 May 18;3:6
references.pmid: 19503749
references.citation: Brain Res Cogn Brain Res. 2005 Apr;23(1):119-36
references.pmid: 15795139
references.citation: Arch Gen Psychiatry. 2005 Jul;62(7):761-8
references.pmid: 15997017
references.citation: BMC Neurosci. 2008 Jul 26;9:72
references.pmid: 18655719
references.citation: Ann N Y Acad Sci. 2008 Apr;1128:41-52
references.pmid: 18469213
references.citation: Science. 2004 Feb 13;303(5660):1023-6
references.pmid: 14963333
references.citation: Neuroimage. 2003 Aug;19(4):1439-48
references.pmid: 12948701
references.citation: Science. 2006 Aug 4;313(5787):684-7
references.pmid: 16888142
references.citation: Science. 1981 Jan 30;211(4481):453-8
references.pmid: 7455683