Dosage compensation and the global re-balancing of aneuploid genomes.
Diploid genomes are exquisitely balanced systems of gene expression. The dosage-compensation systems that evolved along with monosomic sex chromosomes exemplify the intricacies of compensating for differences in gene copy number by transcriptional regulation.
Prestel
Matthias
M
Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.
Feller
Christian
C
Becker
Peter B
PB
D000782:Aneuploidy; D000818:Animals; D004303:Dosage Compensation, Genetic; D005260:Female; D018628:Gene Dosage; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics*; D006801:Humans; D008297:Male; D012730:Sex Chromosomes
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