Effects of a platelet gel on early graft revascularization after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind, clinical trial.
BACKGROUND
Slow graft healing in bone tunnels and a slow graft ligamentization process after anterior cruciate ligament (ACL) reconstruction are some of the reasons for prolonged rehabilitation.


OBJECTIVE
The purpose of this study was to determine if the use of platelet gel (PG) accelerates early graft revascularization after ACL reconstruction.


METHODS
PG was produced from autologous platelet-rich plasma and applied locally. We quantitatively evaluated the revascularization process in the osteoligamentous interface zone in the bone tunnels and in the intra-articular part of the graft by means of contrast-enhanced magnetic resonance imaging (MRI).


RESULTS
After 4-6 weeks, the PG-treated group demonstrated a significantly higher level of vascularization in the osteoligamentous interface (0.33 ± 0.09) than the control group (0.16 ± 0.09, p < 0.001). In the intra-articular part of the graft, we found no evidence of revascularization in either group.


CONCLUSIONS
Locally applied PG enhanced early revascularization of the graft in the osteoligamentous interface zone after ACL reconstruction.
Vogrin
M
M
Department of Orthopedic Surgery, University Hospital Maribor, Maribor, Slovenia. matjazvogrin @ hotmail.com
Rupreht
M
M
Dinevski
D
D
Hašpl
M
M
Kuhta
M
M
Jevsek
M
M
Knežević
M
M
Rožman
P
P
D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000098:blood supply / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D001792:Blood Platelets; D004311:Double-Blind Method; D005260:Female; D005782:Gels / Q000008:administration & dosage / Q000302:isolation & purification; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D017847:Patellar Ligament / Q000637:transplantation; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D012421:Rupture / Q000601:surgery; D014182:Transplantation, Autologous; D014945:Wound Healing; D055815:Young Adult
D005782:Gels