Fatal Staphylococcal infection following classic Dengue fever.
Dengue represents an important public health issue in many tropical areas, leading to high morbidity and the employment of substantial health resources. Even though the number of fatalities related to dengue is unknown, several reports warn about the potential occurrence of severe infections and even death. The clinical spectrum of dengue is highly variable, ranging from a mild flu-like syndrome to severe disease, with shock and hemorrhage. The occurrence of bacterial superinfection, or coinfection, in patients with dengue has been noted by some authors, but the available information comes from anecdotic reports. In this study, we show the clinical and anatomopathological data of a patient infected with dengue, who subsequently died of acute multi-organic failure related to Staphylococcus aureus infection. The autopsy revealed a severe disseminated staphylococcal disease and confirmed dengue infection.
Araújo
Stanley Almeida
SA
Program of Infectious Diseases and Tropical Medicine, Medical School, Federal University of Minas Gerais, Brazil. stanleyaa@gmail.com
Moreira
Daniel Ribeiro
DR
Veloso
Juliana Marcia Ribeiro
JM
Silva
Jenaine Oliveira
JO
Barros
Vera Lucia Souza Reis
VL
Nobre
Vandack
V
D000293:Adolescent; D003715:Dengue / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D013203:Staphylococcal Infections / Q000150:complications*
Braz J Infect Dis. 2003 Dec;7(6):418-22
14636482
Rev Infect Dis. 1986 Nov-Dec;8(6):850-73
3025993
Jpn J Infect Dis. 2006 Jun;59(3):211-2
16785712
Am J Trop Med Hyg. 1996 Mar;54(3):256-9
8600761
Rev Soc Bras Med Trop. 2006 Mar-Apr;39(2):203-10
16699651
Emerg Infect Dis. 2003 Feb;9(2):271
12604005
BMJ. 2002 Jun 29;324(7353):1563-6
12089096
Lancet. 2000 Mar 25;355(9209):1053-9
10744091
Pediatr Infect Dis J. 1998 Jan;17(1):81-2
9469403
Emerg Infect Dis. 1995 Apr-Jun;1(2):55-7
8903160
Trop Med Int Health. 2007 Sep;12(9):1087-95
17875019
Lancet. 2007 Nov 10;370(9599):1644-52
17993365
Rev Soc Bras Med Trop. 2002 Jul-Aug;35(4):401-4
12170337
Pediatr Crit Care Med. 2007 Jul;8(4):389-91
17545933
BMJ Clin Evid. 2009 Jan 12;2009:
19445771
Am J Trop Med Hyg. 1991 Oct;45(4):408-17
1951849
Intern Med. 2007;46(13):1043-6
17603249
Southeast Asian J Trop Med Public Health. 2002 Mar;33(1):49-55
12118460
Southeast Asian J Trop Med Public Health. 1998 Jun;29(2):370-2
9886130
Am J Trop Med Hyg. 2008 Aug;79(2):154-8
18689615
Ann Acad Med Singap. 2007 Oct;36(10):847-50
17987236
Am J Trop Med Hyg. 2005 Feb;72(2):221-6
15741560