title: Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.
authors.affiliation: Department of Chemistry and Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. akghosh@purdue.edu
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Xu
authors.forename: Kalapala Venkateswara
authors.initials: KV
authors.lastname: Rao
authors.forename: Abigail
authors.initials: A
authors.lastname: Baldridge
authors.forename: Johnson
authors.initials: J
authors.lastname: Agniswamy
authors.forename: Yuan-Fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Irene T
authors.initials: IT
authors.lastname: Weber
authors.forename: Manabu
authors.initials: M
authors.lastname: Aoki
authors.forename: Salcedo Gomez Pedro
authors.initials: SG
authors.lastname: Miguel
authors.forename: Masayuki
authors.initials: M
authors.lastname: Amano
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
mesh_terms: D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D000069454:Darunavir; D019281:Dimerization; D015195:Drug Design; D024921:Drug Resistance, Multiple, Viral; D005663:Furans; D015658:HIV Infections / Q000188:drug therapy*; D016333:HIV Protease / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects*; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D008024:Ligands; D011506:Proteins; D013449:Sulfonamides; C095108:amprenavir; D016333:HIV Protease; D000069454:Darunavir
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