title: Less iodine injected for the same diagnostic performances: comparison of two low-osmolar contrast agents (iobitridol 350 and iopamidol 370) in coronary angiography and ventriculography: a randomized double-blind clinical study.
abstract: OBJECTIVE
  Mild reductions in iodine concentration could reduce acute side effects after intraarterial contrast media administration without affecting the quality of coronary artery images. This study was designed to show the equivalence in terms of image quality of two nonionic low-osmolar monomers, iobitridol 350 and iopamidol 370, and to compare their clinical safety in coronary angiography and ventriculography.
  
  
  RESULTS
  In this multicentre, double-blind clinical trial, 98 adult patients were randomized to receive either iobitridol 350 or iopamidol 370. The image quality (primary evaluation criterion) of the whole examination was assessed using a 5-point scale (poor, fair, moderate, good, excellent). Secondary endpoints were the image quality per territory, diagnostic efficacy, practical comfort (5-point scale: impossible to evaluate, not practical, moderately practical, practical, very practical to use) and clinical safety (adverse events and vital signs). The proportions of examinations presenting with good or excellent global image quality was similar with both contrast media: 87.8% with iobitridol 350 vs. 89.8% with iopamidol 370. Similar results were observed when considering the image quality specifically for each major coronary artery and left ventricle. No difference between groups was found with respect to other secondary criteria. Adverse events occurred in 7 patients with iobitridol 350 (14.3%) and in 10 patients with iopamidol 370 (20.4%).
  
  
  CONCLUSIONS
  This study showed that, with regard to image quality and diagnostic efficacy and using a lower iodine concentration, iobitridol 350 was comparable to iopamidol 370 in adult patients requiring coronary angiography and ventriculography for diagnostic indications.
authors.affiliation: Hospital Universitario Doce de Octubre, Madrid, Spain. maitevel05@gmail.com
authors.forename: Maríia Teresa
authors.initials: MT
authors.lastname: Velázquez
authors.forename: Agustín
authors.initials: A
authors.lastname: Albarrán
authors.forename: Felipe
authors.initials: F
authors.lastname: Hernández
authors.forename: Julio
authors.initials: J
authors.lastname: García Tejada
authors.forename: Javier
authors.initials: J
authors.lastname: Zueco
authors.forename: Javier
authors.initials: J
authors.lastname: Andreu
authors.forename: Jose-María
authors.initials: JM
authors.lastname: De la Torre
authors.forename: Alvaro
authors.initials: A
authors.lastname: Figueroa
authors.forename: Fermin
authors.initials: F
authors.lastname: Sainz
authors.forename: Juan
authors.initials: J
authors.lastname: Tascón
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D017023:Coronary Angiography; D004311:Double-Blind Method; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007269:Injections, Intra-Arterial; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D007479:Iopamidol / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D013030:Spain
chemical_list: D003287:Contrast Media; C093233:iobitridol; D007472:Iohexol; D007479:Iopamidol