title: [Current therapy of carcinoma of the skin].
abstract: Interferon alpha as adjuvant therapy in high risk melanoma delays relapses and distant metastasis as shown in large clinical trials and meta-analysis. There are clear signs that a long term low dose interferon therapy is especially effective in patients with micrometastasis (detected by sentinel node biopsy).Patient with stage IV melanoma (distant metastasis) need systemic therapy in most cases. Since until today there is no treatment that has been proven to prolong the overall survival for this patient population. We recommend according international guidelines that these patients are treated in the context of clinical trials in a melanoma reference center.
authors.affiliation: Dermatologische Klinik, UniversitätsSpital Zürich, Gloriastrasse, Zürich.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dummer
authors.forename: Simone M
authors.initials: SM
authors.lastname: Goldinger
authors.forename: Eva
authors.initials: E
authors.lastname: Sailer
authors.forename: Lars E
authors.initials: LE
authors.lastname: French
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D062109:Dermatologic Surgical Procedures; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care; D021701:Sentinel Lymph Node Biopsy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha