title: Mesenchymal stem cells in arthritis: role of bone marrow microenvironment.
abstract: Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs are potent immunomodulatory cells that occur through the secretion of soluble mediators including nitric oxide, transforming growth factor beta, and HLAG5. The MSCs, however, are also able to express inflammatory mediators such as prostaglandin E2 or IL-6. MSCs in the bone marrow are in close contact with T cells and B cells, and they regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow. The role of MSCs in arthritis remains controversial - in some studies, murine allogeneic MSCs are able to decrease arthritis; in other studies, MSCs worsen the local inflammation. A recent paper in Arthritis Research and Therapy shows that bone marrow MSCs have decreased osteoblastic potential in rheumatoid arthritis, which may be related to chronic inflammation or to loss of expression of IL-1 receptor agonist. That article raises the importance of the bone marrow microenvironment for MSC biology.
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
mesh_terms: D001853:Bone Marrow / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation / Q000276:immunology*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D012038:Regeneration / Q000276:immunology*; D012216:Rheumatic Diseases / Q000276:immunology*
references.citation: Arthritis Res Ther. 2010;12(4):R149
references.pmid: 20649960
references.citation: Blood. 2005 Sep 1;106(5):1755-61
references.pmid: 15905186
references.citation: Immunity. 2009 May;30(5):721-30
references.pmid: 19427242
references.citation: Osteoarthritis Cartilage. 2003 Nov;11(11):790-800
references.pmid: 14609532
references.citation: Arthritis Rheum. 2001 Jan;44(1):85-95
references.pmid: 11212180
references.citation: Exp Cell Res. 2006 Jul 15;312(12):2169-79
references.pmid: 16631737
references.citation: Arthritis Res Ther. 2005;7(6):R1304-15
references.pmid: 16277684
references.citation: J Musculoskelet Neuronal Interact. 2002 Jun;2(4):309-20
references.pmid: 15758422
references.citation: Regen Med. 2006 Jul;1(4):529-37
references.pmid: 17465847
references.citation: Arthritis Rheum. 2007 Apr;56(4):1175-86
references.pmid: 17393437
references.citation: Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17438-43
references.pmid: 17088535
references.citation: Exp Cell Res. 2008 Apr 15;314(7):1575-84
references.pmid: 18325494
references.citation: Arthritis Rheum. 2005 May;52(5):1595-603
references.pmid: 15880818
references.citation: Scand J Immunol. 2003 Jan;57(1):11-20
references.pmid: 12542793