title: 3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry.
abstract: An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound is shown to be a promising building block for further selective derivatization of the cyclobutane ring providing novel conformationally restricted piperidine derivatives.
authors.affiliation: Enamine Ltd., Vul. Oleksandra Matrosova 23, 01103 Kyiv, Ukraine.
authors.forename: Aleksandr V
authors.initials: AV
authors.lastname: Denisenko
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Mityuk
authors.forename: Oleksandr O
authors.initials: OO
authors.lastname: Grygorenko
authors.forename: Dmytro M
authors.initials: DM
authors.lastname: Volochnyuk
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Shishkin
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tolmachev
authors.forename: Pavel K
authors.initials: PK
authors.lastname: Mykhailiuk
mesh_terms: D001593:Benzyl Compounds / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D006536:Heptanes / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: C554397:3-benzyl-3-azabicyclo(3.1.1)heptan-6-one; D001593:Benzyl Compounds; D001643:Bridged Bicyclo Compounds; D006536:Heptanes