title: Dental caries in diabetes mellitus: role of salivary flow rate and minerals.
abstract: This study was designed to evaluate the possible protective role of salivary factors like salivary flow rate and adequate level of calcium, phosphate, and fluoride in diabetes mellitus type 2 patients with dental caries. A total of 398 diabetes mellitus type 2 patients with dental caries and 395 age- and sex-matched non-diabetic subjects with dental caries were included as controls, all of whom gave informed consent. All subjects were divided into four groups according to their age. Decayed, missed, and filled teeth (DMFT) were scored to indicate the severity of dental caries. Saliva was collected, flow rate was noted, and calcium, phosphate, and fluoride were analyzed. The blood glucose, HbA1c, and DMFT indices were found to be significantly high in diabetic patients as compared to controls. The salivary flow rate, calcium, phosphate, and fluoride were found to be significantly low whereas no significant difference was found in salivary magnesium in patients as compared to controls. Optimum salivary flow rate is responsible for establishing protective environment against dental caries. Adequate level of salivary calcium, phosphate, and fluoride is also involved in significant deposition of these minerals in plaque, which greatly reduces the development of caries in the adjacent enamel of teeth.
authors.affiliation: Department of Biochemistry, Liaquat College of Medicine & Dentistry, Karachi, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Jawed
authors.forename: Syed M
authors.initials: SM
authors.lastname: Shahid
authors.forename: Shah A
authors.initials: SA
authors.lastname: Qader
authors.forename: Abid
authors.initials: A
authors.lastname: Azhar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003731:Dental Caries / Q000209:etiology* / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism*; D005260:Female; D005459:Fluorides / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D001786:Blood Glucose; D008903:Minerals; D010710:Phosphates; D008274:Magnesium; D005459:Fluorides; D002118:Calcium