title: Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles.
abstract: 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.
authors.affiliation: The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Sen W
authors.initials: SW
authors.lastname: Kwok
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Fotsing
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Fraser
authors.forename: Valentin O
authors.initials: VO
authors.lastname: Rodionov
authors.forename: Valery V
authors.initials: VV
authors.lastname: Fokin
mesh_terms: D002384:Catalysis; D006878:Hydroxides / Q000737:chemistry; D015394:Molecular Structure; D028561:Transition Elements / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D006878:Hydroxides; D028561:Transition Elements; D014230:Triazoles
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