title: Ubiquinol-10 and ubiquinone-10 levels in umbilical cord blood of healthy foetuses and the venous blood of their mothers.
abstract: Despite their being good markers of oxidative stress for clinical use, little is known about ubiquinol-10 (reduced coenzyme Q10) and ubiquinone-10 (oxidized coenzyme Q10) levels in foetuses and their mothers. This study investigates oxidative stress in 10 healthy maternal venous, umbilical arterial and venous bloods after vaginal delivery by measuring ubiquinol-10 and ubiquinone-10 levels. Serum ubiquinol-10 and ubiquinone-10 levels were measured by HPLC with a highly sensitive electrochemical detector. Maternal venous ubiquinol-10 and ubiquinone-10 levels were significantly higher than umbilical arterial and venous levels (all p < 0.001). However, the ubiquinone-10/total coenzyme Q10 (CoQ10) ratio, which reflects the redox status, was significantly higher in umbilical arterial and umbilical venous blood compared to maternal venous blood (all p < 0.001). The ubiquinone-10/total CoQ10 ratio was higher in umbilical arterial than in umbilical venous blood (p < 0.01). The present study demonstrated that foetuses were under higher oxidative stress than their mothers.
authors.affiliation: Department of Midwifery and Women's Health, Division of Health Sciences & Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. msumi-tky@umin.ac.jp
authors.forename: Masayo
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: Megumi
authors.initials: M
authors.lastname: Haruna
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hasumi
authors.forename: Kyouichi
authors.initials: K
authors.lastname: Sekine
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanizaki
authors.forename: Etsuko
authors.initials: E
authors.lastname: Watanabe
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Murashima
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism*; D005333:Fetus; D006801:Humans; D009035:Mothers; D011247:Pregnancy / Q000097:blood*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014451:Ubiquinone; C025204:Ubiquinone Q2; C003741:ubiquinol