title: Multicenter epidemiological studies of atherosclerosis imaging.
abstract: Cardiovascular disease is the leading course of death and disability. Conventional cardiac risk factors do not fully explain the level of cardiovascular risk, incidence of coronary artery disease, and coronary events. Risk stratification and therapy based solely on these conventional risk factors may overlook a population who would benefit from lifestyle and risk factor modification. Thus, research has recently focused on improving risk assessment with new tools in an effort to better identify subjects at highest risk and in need of aggressive management. Cardiovascular imaging, both in coronary and extracoronary arterial beds, has proven to be very helpful in this regard. In this article, we review the current literature from multicenter epidemiology studies on the utility of noninvasive imaging modalities for risk stratification in the context of conventional risk factor evaluation.
authors.affiliation: Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD 20892, USA.
authors.forename: Songtao
authors.initials: S
authors.lastname: Liu
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
mesh_terms: D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000453:epidemiology*; D003331:Coronary Vessels / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D018450:Disease Progression; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018084:Ultrasonography, Interventional
references.citation: Eur Heart J. 1990 Aug;11 Suppl E:3-19
references.pmid: 1699762
references.citation: N Engl J Med. 2008 Mar 27;358(13):1336-45
references.pmid: 18367736
references.citation: Circulation. 2007 May 29;115(21):2722-30
references.pmid: 17502571
references.citation: JAMA. 2004 Nov 17;292(19):2350-6
references.pmid: 15547162
references.citation: Atherosclerosis. 2008 Apr;197(2):777-83
references.pmid: 17920067
references.citation: Radiology. 2002 Jun;223(3):789-97
references.pmid: 12034951
references.citation: N Engl J Med. 2007 Jun 7;356(23):2388-98
references.pmid: 17554120
references.citation: J Am Coll Cardiol. 2003 Oct 1;42(7):1199-205
references.pmid: 14522480
references.citation: Circulation. 2002 Jul 16;106(3):296-9
references.pmid: 12119242
references.citation: Circulation. 2008 Feb 12;117(6):743-53
references.pmid: 18212285
references.citation: Radiology. 1993 Apr;187(1):261-8
references.pmid: 8451425
references.citation: Am J Cardiol. 2006 Dec 15;98(12):1660-4
references.pmid: 17145230
references.citation: Circulation. 1995 Aug 1;92(3):380-7
references.pmid: 7634452
references.citation: Radiology. 1989 Aug;172(2):349-50
references.pmid: 2748813
references.citation: Annu Rev Biomed Eng. 2000;2:431-56
references.pmid: 11701519
references.citation: J Am Coll Cardiol. 2004 Sep 1;44(5):1011-7
references.pmid: 15337212
references.citation: JAMA. 2004 Nov 17;292(19):2396-8
references.pmid: 15547168
references.citation: Circulation. 2006 Feb 14;113(6):791-8
references.pmid: 16461820
references.citation: Ann Intern Med. 1989 Jan 15;110(2):101-7
references.pmid: 2521199
references.citation: Circulation. 2000 Jan 25;101(3):244-51
references.pmid: 10645919
references.citation: Int Heart J. 2005 May;46(3):419-31
references.pmid: 16043938
references.citation: Circulation. 2007 Jan 23;115(3):402-26
references.pmid: 17220398
references.citation: Eur Heart J. 2005 Nov;26(21):2320-4
references.pmid: 15972291
references.citation: JAMA. 2004 Jan 14;291(2):210-5
references.pmid: 14722147
references.citation: N Engl J Med. 1990 May 31;322(22):1561-6
references.pmid: 2139921
references.citation: JAMA. 2002 Sep 25;288(12):1491-8
references.pmid: 12243636
references.citation: J Am Coll Cardiol. 2003 Jan 1;41(1):39-44
references.pmid: 12570942
references.citation: Radiology. 2001 Apr;219(1):264-9
references.pmid: 11274568
references.citation: Ann Intern Med. 1970 Jun;72(6):813-22
references.pmid: 4247338
references.citation: J Am Coll Cardiol. 2006 Sep 5;48(5):1018-26
references.pmid: 16949496
references.citation: J Am Coll Cardiol. 2006 Mar 21;47(6):1159-60
references.pmid: 16545645
references.citation: AJR Am J Roentgenol. 2006 Jun;186(6 Suppl 2):S401-6
references.pmid: 16714616
references.citation: Radiology. 2006 Nov;241(2):338-54
references.pmid: 17057063
references.citation: J Magn Reson Imaging. 2008 Nov;28(5):1108-15
references.pmid: 18837001
references.citation: J Am Coll Cardiol. 2006 Dec 5;48(11):2285-92
references.pmid: 17161261
references.citation: Am J Cardiol. 2001 May 1;87(9):1051-7
references.pmid: 11348601
references.citation: J Am Coll Cardiol. 2006 Mar 21;47(6):1150-8
references.pmid: 16545644
references.citation: Radiology. 1988 Oct;169(1):59-63
references.pmid: 3420283
references.citation: Stroke. 2006 Jan;37(1):87-92
references.pmid: 16339465
references.citation: J Comput Assist Tomogr. 2009 Jan-Feb;33(1):1-7
references.pmid: 19188777
references.citation: Circulation. 2006 Oct 17;114(16):1761-91
references.pmid: 17015792
references.citation: AJR Am J Roentgenol. 2006 Jun;186(6 Suppl 2):S357-65
references.pmid: 16714609
references.citation: J Am Coll Cardiol. 2005 Sep 6;46(5):807-14
references.pmid: 16139129
references.citation: N Engl J Med. 1999 Jan 7;340(1):14-22
references.pmid: 9878640
references.citation: Am J Epidemiol. 2002 Nov 1;156(9):871-81
references.pmid: 12397006
references.citation: AJR Am J Roentgenol. 2008 Feb;190(2):W87-92
references.pmid: 18212206
references.citation: J Am Coll Cardiol. 2000 May;35(6):1628-37
references.pmid: 10807470
references.citation: Circulation. 1986 Dec;74(6):1399-406
references.pmid: 3536154
references.citation: J Am Coll Cardiol. 2004 Aug 18;44(4):923-30
references.pmid: 15312881
references.citation: Circulation. 2005 Mar 15;111(10):1313-20
references.pmid: 15769774
references.citation: Eur Heart J. 2008 Sep;29(18):2244-51
references.pmid: 18573867
references.citation: J Am Coll Cardiol. 1992 Nov 1;20(5):1118-26
references.pmid: 1401612
references.citation: Circulation. 2007 Jan 16;115(2):180-7
references.pmid: 17200444
references.citation: Int J Cardiol. 2007 Apr 25;117(2):227-31
references.pmid: 16875746
references.citation: Magn Reson Med. 2001 Nov;46(5):848-54
references.pmid: 11675634
references.citation: Circulation. 2006 Jan 3;113(1):30-7
references.pmid: 16365194
references.citation: Am J Cardiol. 2007 Feb 1;99(3):310-4
references.pmid: 17261388
references.citation: Am J Epidemiol. 2005 Sep 1;162(5):421-9
references.pmid: 16076829
references.citation: N Engl J Med. 1987 May 28;316(22):1371-5
references.pmid: 3574413
references.citation: Am Heart J. 2007 Apr;153(4):545-51
references.pmid: 17383292
references.citation: J Magn Reson Imaging. 2008 Jul;28(1):60-6
references.pmid: 18581356
references.citation: Circulation. 2004 Sep 14;110(11):1456-62
references.pmid: 15326072
references.citation: Atherosclerosis. 2000 Jun;150(2):321-9
references.pmid: 10856524
references.citation: Circulation. 1993 Mar;87(3 Suppl):II56-65
references.pmid: 8443925
references.citation: Am J Cardiol. 2002 Jul 1;90(1):29-34
references.pmid: 12088775
references.citation: Top Magn Reson Imaging. 2008 Feb;19(1):3-13
references.pmid: 18690156
references.citation: Semin Roentgenol. 2009 Apr;44(2):67-83
references.pmid: 19233083
references.citation: JAMA. 2004 Nov 17;292(19):2343-9
references.pmid: 15547161
references.citation: Am J Epidemiol. 1997 Sep 15;146(6):483-94
references.pmid: 9290509
references.citation: Circulation. 2001 Nov 27;104(22):2679-84
references.pmid: 11723018
references.citation: Am J Cardiol. 1992 Nov 1;70(13):1180-4
references.pmid: 1414943
references.citation: J Med Screen. 2004;11(1):3-7
references.pmid: 15006106
references.citation: J Am Coll Cardiol. 2008 Dec 16;52(25):2148-55
references.pmid: 19095132
references.citation: Eur Heart J. 2003 Sep;24(17):1601-10
references.pmid: 12964575
references.citation: J Cardiovasc Magn Reson. 2005;7(2):409-13
references.pmid: 15881522
references.citation: J Am Coll Cardiol. 2005 Jul 5;46(1):158-65
references.pmid: 15992651
references.citation: J Am Coll Cardiol. 2003 Jun 4;41(11):1863-74
references.pmid: 12798553
references.citation: Herz. 2000 Jun;25(4):392-9
references.pmid: 10948775
references.citation: J Am Coll Cardiol. 2007 Feb 6;49(5):594-600
references.pmid: 17276184
references.citation: Eur Heart J. 2000 Aug;21(16):1387-96
references.pmid: 10952828
references.citation: J Am Coll Cardiol. 2009 May 5;53(18):1708-15
references.pmid: 19406347
references.citation: Hypertension. 1997 May;29(5):1095-103
references.pmid: 9149672
references.citation: Circulation. 2005 Jul 26;112(4):572-7
references.pmid: 16009800
references.citation: Radiology. 2003 Sep;228(3):826-33
references.pmid: 12869688