title: Dimerization of functional pyrroloindolizines for the synthesis of complex myrmicarin alkaloids.
abstract: The union of functionalized pyrroloindolizines for the synthesis of heterodimeric products relevant to myrmicarin alkaloids is described. Design and synthesis of tricyclic substrates and new methods for their union enable the investigation of late-stage cyclopentannulation strategies. The rapid assembly of dimeric structures using unique modes of pyrroloindolizine reactivity presents a concise approach to the dimeric myrmicarins and relevant derivatives.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Alison E
authors.initials: AE
authors.lastname: Ondrus
authors.forename: H Ümit
authors.initials: HU
authors.lastname: Kaniskan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Movassaghi
references.citation: Chem Soc Rev. 2007 Jul;36(7):1173-93
references.pmid: 17576484
references.citation: Chem Commun (Camb). 2009 Jul 28;(28):4151-65
references.pmid: 19585010
references.citation: Org Lett. 2003 Nov 13;5(23):4305-7
references.pmid: 14601986
references.citation: Tetrahedron. 2006 May 29;62(22):5287-5297
references.pmid: 20640170
references.citation: J Am Chem Soc. 2004 Aug 11;126(31):9552-3
references.pmid: 15291554
references.citation: Org Lett. 2005 Sep 29;7(20):4423-6
references.pmid: 16178549
references.citation: J Org Chem. 2001 Apr 6;66(7):2522-5
references.pmid: 11281803
references.citation: J Org Chem. 2007 Dec 21;72(26):10065-74
references.pmid: 18020368
references.citation: J Org Chem. 2000 May 9;65(9):2824-6
references.pmid: 10808465
references.citation: Org Lett. 2009 Jul 16;11(14):2960-3
references.pmid: 19586059
references.citation: Chem Commun (Camb). 2006 Feb 14;(6):665-7
references.pmid: 16446845
references.citation: Org Lett. 2005 Nov 10;7(23):5207-9
references.pmid: 16268539