title: Crimean-Congo hemorrhagic fever in a dengue-endemic region: lessons for the future.
abstract: Crimean-Congo hemorrhagic fever and dengue hemorrhagic fever are endemic in Pakistan. However, the overlap of geographic distribution and early clinical features between the two conditions make a reliable diagnosis difficult in the initial stage of illness. A 16-year-old boy presented with a history of hematemesis and high-grade fever. A preliminary diagnosis of dengue hemorrhagic fever was made and supportive treatment was instituted; however, the patient continued to deteriorate clinically. Dengue IgM antibody testing was negative on the third day of admission. Qualitative polymerase chain reaction test for Crimean-Congo hemorrhagic fever viral RNA was sent but the patient expired shortly after the results became available on the sixth day of admission. Considerable resources had to be expended on contact tracing and administration of ribavirin prophylaxis to all the health-care workers who had come in contact with the patient. It is crucial that Crimean-Congo hemorrhagic fever be recognized and treated at an early stage because of longer term financial and health implications for contacts such as health-care workers in the setting of a developing country. Increased surveillance of dengue and Crimean-Congo hemorrhagic fever cases is warranted for the derivation of reasonably reliable, cost-effective and prompt predictors of disease diagnosis. These predictors can help guide future decisions in the management of similar cases. Ultimately, such a strategy may translate into better cost containment in resource-poor settings. Institution of ribavirin prophylaxis in selected patients also merits consideration.
authors.affiliation: Department of Medicine, Aga Khan University, Karachi, Pakistan. farheen.ali@aku.edu
authors.forename: Farheen
authors.initials: F
authors.lastname: Ali
authors.forename: Taimur
authors.initials: T
authors.lastname: Saleem
authors.forename: Umair
authors.initials: U
authors.lastname: Khalid
authors.forename: Syed Faisal
authors.initials: SF
authors.lastname: Mehmood
authors.forename: Bushra
authors.initials: B
authors.lastname: Jamil
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D018890:Chemoprevention / Q000379:methods; D003715:Dengue / Q000453:epidemiology; D003937:Diagnosis, Differential; D019353:Endemic Diseases; D017809:Fatal Outcome; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000302:isolation & purification*; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis*; D006801:Humans; D017053:Infection Control / Q000379:methods; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012254:Ribavirin / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D012254:Ribavirin