Serum biological antioxidant potential predicts the prognosis of hemodialysis patients.
BACKGROUND
It is well known that oxidative stress is enhanced in patients with end-stage renal disease. However, little is known about the relationship between serum antioxidant capacity and clinical outcome in hemodialysis (HD) patients.


METHODS
We examined the relationship between serum biomarkers of oxidative stress and clinical outcomes including all-cause mortality, hospitalization rate and incidence of cardiovascular events in HD patients. As biomarkers of oxidative stress, we measured serum levels of coenzyme Q10 (CoQ10) and biological antioxidant potential (BAP).


RESULTS
108 patients were observed for 30 months as the follow-up periods. The survival group (n = 83) showed significantly higher BAP values compared with those in death groups (n = 25; p < 0.05). When serum BAP levels were divided into two groups by their median value, the group with higher BAP values had a better survival rate than that with lower BAP values on the Kaplan-Meier survival analysis (p = 0.05). Although serum levels of CoQ10 did not show any association with clinical outcomes, lower BAP was selected as an independent risk factor for all-cause mortality as well as the absence of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers therapy by age-adjusted Cox regression analysis.


CONCLUSIONS
This study indicated that BAP could predict the prognosis of HD patients.
Ishii
Tomoko
T
Department of Nephrology, Immunology, and Vascular Medicine, Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan.
Ohtake
Takayasu
T
Okamoto
Koji
K
Mochida
Yasuhiro
Y
Ishioka
Kunihiro
K
Oka
Machiko
M
Maesato
Kyoko
K
Ikee
Ryota
R
Moriya
Hidekazu
H
Hidaka
Sumi
S
Doi
Kent
K
Noiri
Eisei
E
Fujita
Toshiro
T
Kobayashi
Shuzo
S
D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality; D015996:Survival Rate / Q000639:trends
D000975:Antioxidants; D015415:Biomarkers