title: Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
abstract: Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0·005). Similar associations were seen with the double-strand break repair (P = 0·02) and nucleotide excision repair (P = 0·04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP ≤ 0·05), or because of high level of statistical significance (P ≤ 0·005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Shen
authors.forename: Idan
authors.initials: I
authors.lastname: Menashe
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bruce
authors.initials: B
authors.lastname: Armstrong
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Andrew
authors.initials: A
authors.lastname: Grulich
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holford
authors.forename: Claire M
authors.initials: CM
authors.lastname: Vajdic
authors.forename: Scott
authors.initials: S
authors.lastname: Davis
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Anne
authors.initials: A
authors.lastname: Kricker
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Shelia H
authors.initials: SH
authors.lastname: Zahm
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Chatterjee
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D004273:DNA, Neoplasm
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