title: Diagnosis of pulmonary Langerhans cell histiocytosis by CT-guided core biopsy of lung: a report of three cases.
abstract: A pathological diagnosis of pulmonary Langerhans cell histiocytosis (PLCH) usually requires a surgical lung biopsy. To date, diagnosis of PLCH by core needle biopsy has not been reported. Three cases are presented of PLCH diagnosed by CT-guided core biopsy in adult female smokers found to have multiple small bilateral lung nodules. The nodules biopsied were 5 mm, 7 mm and 1 cm in size, and showed interstitial expansion by Langerhans cells and eosinophils. CT-guided core biopsy should be considered as one of the less invasive techniques by which a pathological diagnosis of PLCH can be established.
authors.affiliation: Department of Pathology, State University of New York Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210, USA. mukhopas@upstate.edu
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Shea M
authors.initials: SM
authors.lastname: Eckardt
authors.forename: Ernest M
authors.initials: EM
authors.lastname: Scalzetti
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D015641:Radiography, Interventional / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods