title: Influence of deltamethrin on nonspecific cellular and humoral defense mechanisms in rainbow trout (Oncorhynchus mykiss).
abstract: The influence of deltamethrin on the innate immunity in rainbow trout was examined. Fish were immersed in deltamethrin at doses of 1, 2, and 4 microg/L for 30 min. The results showed that deltamethrin at doses of 2 and 4 microg/L decreased phagocytic activity of spleen macrophages and proliferative response of pronephros lymphocytes at days 1, 2, and 5 after immersion. Deltamethrin at these doses decreased the lysozyme activity, total protein, and immunoglobulin levels in serum. The greatest immunosuppressive influence of deltamethrin at dose 4 microg/L was observed at the end of the study.
authors.affiliation: Department of Infection Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn-Kortowo II, Poland. aksiw@infish.com.pl
authors.forename: Andrzej K
authors.initials: AK
authors.lastname: Siwicki
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Terech-Majewska
authors.forename: Joanna
authors.initials: J
authors.lastname: Grudniewska
authors.forename: Joanna
authors.initials: J
authors.lastname: Malaczewska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kazun
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lepa
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D007113:Immunity, Innate / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009570:Nitriles / Q000633:toxicity*; D017686:Oncorhynchus mykiss / Q000276:immunology*; D011722:Pyrethrins / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014874:Water Pollutants, Chemical; C017180:decamethrin