title: Oxygen cost of treadmill and over-ground walking in mildly disabled persons with multiple sclerosis.
abstract: Walking impairment is a ubiquitous feature of multiple sclerosis (MS) and the O(2) cost of walking might quantify this dysfunction in mild MS. This paper examined the difference in O(2) cost of walking between persons with MS who have mild disability and healthy controls and the correlation between the O(2) cost of walking and disability. Study 1 included 18 persons with mild MS and 18 controls and indicated that the O(2) cost of walking was significantly higher in MS than controls and that disability was significantly associated with the O(2) cost of slow, moderate, and fast treadmill walking. Study 2 included 24 persons with mild MS and indicated that disability was significantly correlated with O(2) cost of comfortable, fast, and slow over-ground walking. We provide evidence that the O(2) cost of walking is an indicator of walking dysfunction in mildly disabled persons with MS and should be considered in clinical research and practice.
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 350 Freer Hall, 906 South Goodwin Ave., Urbana, IL 61801, USA. robmotl@illinois.edu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Motl
authors.forename: Yoojin
authors.initials: Y
authors.lastname: Suh
authors.forename: Deirdre
authors.initials: D
authors.lastname: Dlugonski
authors.forename: Madeline
authors.initials: M
authors.lastname: Weikert
authors.forename: Stamatis
authors.initials: S
authors.lastname: Agiovlasitis
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
authors.forename: Myla
authors.initials: M
authors.lastname: Goldman
mesh_terms: D000293:Adolescent; D000328:Adult; D006233:Persons with Disabilities; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology*; D016138:Walking / Q000502:physiology*; D055815:Young Adult
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