title: Predictive values of QuantiFERON-TB Gold testing in screening for tuberculosis disease in asylum seekers.
abstract: Screening with chest X-ray and the Mantoux test (the tuberculin skin test [TST]) is compulsory for adult asylum seekers who arrive in Norway. In 2005-2006, we included 823 asylum seekers in a study of the QuantiFERON-TB Gold test (QFT-G), and followed them for 23-32 months. Eight subjects with a positive and one with a negative QFT-G test were diagnosed with tuberculosis (TB). The positive (PPV) and negative predictive values (NPV) for TB were respectively 3.3% and 99.8%. The PPV was 2.3% and the NPV 99.1% for TST >or= 15 mm, and the NPV was 99.5% for TST >or= 6 mm in combination with a negative QFT-G.
authors.affiliation: Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway. ingunn.harstad@ntnu.no
authors.forename: I
authors.initials: I
authors.lastname: Harstad
authors.forename: B A
authors.initials: BA
authors.lastname: Winje
authors.forename: E
authors.initials: E
authors.lastname: Heldal
authors.forename: F
authors.initials: F
authors.lastname: Oftung
authors.forename: G W
authors.initials: GW
authors.lastname: Jacobsen
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D055985:Latent Tuberculosis / Q000175:diagnosis*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009664:Norway; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012036:Refugees; D014374:Tuberculin Test; D014376:Tuberculosis / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma