[The significance of radiation therapy for symptomatic vertebral hemangiomas (SVH)].
OBJECTIVE
To evaluate the efficacy of radiation therapy (RT) for symptomatic vertebral hemangioma (SVH).


METHODS
Based on the Registry for Rare Benign Disorders (RRBD) of the German Cooperative Group on Radiation Therapy for Benign Diseases (GCG-BD), the clinical information, treatment plans and outcome data from seven cooperating German RT institutions were analyzed retrospectively.


RESULTS
Over a period of 39 years (1969-2008), a total of 84 patients with 96 symptomatic lesions underwent RT. The predominant indication was pain in 97.6%, and, in addition, 28.6% of patients had neurological deficits. The median total dose was 34 Gy (4.5-45 Gy), and the median single dose 2.0 Gy (0.5-3.0 Gy). After a median follow-up of 68 months (6-422 months), complete symptom relief (CR) occurred in 61.9% of patients, 28.6% had partial relief, and 9.5% had no relief (NR). The overall response rate (CR + PR) was 90.5%. In 26.2% of patients, radiologic signs of remineralization were noted. After a median follow-up of 70 months (8-124 months), symptom progression occurred in eight patients (9.5%). Therefore, the long-term rate of local control was 80.9%. Multivariate statistical analysis revealed a significantly higher rate of symptom relief and local control for total doses > or = 34 Gy. Side effects > RTOG/EORTC grade 2 were not observed.


CONCLUSIONS
RT is a safe and effective for treatment of SVH. Total doses of at least 34 Gy are recommended to achieve optimal treatment response.
Heyd
Reinhard
R
Strahlenklinik, Klinikum Offenbach, Offenbach, Germany. Reiniheyd@aol.com
Seegenschmiedt
M Heinrich
MH
Rades
Dirk
D
Winkler
Cornelia
C
Eich
Hans T
HT
Bruns
Frank
F
Gosheger
Georg
G
Willich
Normann
N
Micke
Oliver
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011879:Radiotherapy Dosage; D012042:Registries; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D013130:Spinal Stenosis / Q000175:diagnosis / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
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