CSF Biomarkers Profile in CADASIL-A Model of Pure Vascular Dementia: Usefulness in Differential Diagnosis in the Dementia Disorder.
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is considered a model of pure vascular dementia (VD) because it occurs in young adults unlikely to have concomitant age and Alzheimer's Disease-(AD-) related pathology. CSF levels of β-amyloid 1-42 (Aβ42), total tau protein (t-tau), and phosphorylated tau-protein (p-tau), well accepted biomarkers of AD, were evaluated in 10 CADASIL patients, 22 AD patients, and 17 healthy age-matched subjects. Innotest β-amyloid 1-42, Innotest hTAU-Ag, and Innotest Phospho-tau 181p sandwich enzyme-linked immunoassay were used to determine CSF biomarkers levels. A case-control statistical analysis was carried out. CSF Aβ42 levels were significantly lower in CADASIL patients and considerable overlap with AD whereas t-tau and p-tau levels were normal and significantly different with respect to AD. A significant altered CSF biomarkers profile in a pure VD supports the use of CSF Aβ42, t-tau, and p-tau levels in the differential diagnosis of VD and AD.
Formichi
Patrizia
P
Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, 53100 Siena, Italy.
Parnetti
Lucilla
L
Radi
Elena
E
Cevenini
Gabriele
G
Dotti
Maria Teresa
MT
Federico
Antonio
A
Nat Genet. 1993 Mar;3(3):256-9
8485581
Eur J Neurol. 2007 Jan;14(1):e1-26
17222085
Neurol Sci. 2008 Dec;29(6):417-23
19011737
Neurosci Lett. 2005 Jul 22-29;383(1-2):12-6
15936505
Neurodegeneration. 1995 Dec;4(4):433-42
8846237
Med Sci Monit. 2003 Nov;9(11):CR484-8
14586274
J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):298-305
9527138
Eur J Neurol. 2009 Feb;16(2):205-11
19146641
J Neurol Neurosurg Psychiatry. 2009 Jan;80(1):41-7
18829627
Neurology. 1984 Jul;34(7):939-44
6610841
Acta Neuropathol. 1996;91(2):219-20
8787159
Acta Neuropathol. 2007 Apr;113(4):349-88
17285295
Eur J Neurol. 2008 Nov;15(11):1252-5
18803653
Neurology. 2006 May 23;66(10):1523-6
16717212
Lancet Neurol. 2006 Mar;5(3):228-34
16488378
J Cell Physiol. 2006 Jul;208(1):39-46
16447254
Neurosci Lett. 2003 Mar 20;339(2):172-4
12614922
Arch Neurol. 1999 Jun;56(6):673-80
10369305
Lancet Neurol. 2009 Jul;8(7):643-53
19539236
Ann Clin Biochem. 2009 May;46(Pt 3):235-40
19342441
J Geriatr Psychiatry Neurol. 2005 Sep;18(3):163-73
16100106
Lancet. 2003 Feb 15;361(9357):605-8
12598159
J Neurol Sci. 2005 Oct 15;237(1-2):83-8
15990115
NeuroRx. 2004 Apr;1(2):213-25
15717022
Ann Neurol. 2003 Aug;54(2):263-7
12891683
Lancet Neurol. 2004 Mar;3(3):141
14980525
Neurology. 2006 Sep 12;67(5):830-3
16966546
J Neurol Neurosurg Psychiatry. 2005 May;76(5):736-8
15834039
Trends Neurosci. 1993 Nov;16(11):460-5
7507619
Neurosci Lett. 1998 Nov 13;256(3):174-6
9855368
Dement Geriatr Cogn Disord. 2002;14(4):183-90
12411760
Alzheimer Dis Assoc Disord. 1999 Oct-Dec;13 Suppl 3:S115-23
10609690
Neurology. 1995 Jun;45(6):1086-91
7783868
Lancet Neurol. 2004 Mar;3(3):184-90
14980533