title: Urinary tract infections in the era of newer immunosuppressant agents: a tertiary care center study.
abstract: We studied the incidence and the risk factors predisposing to post transplantation urinary tract infection (UTI) and the association with use of different immunosuppressive regimens. We performed a retrospective analysis of 152 recipients of renal transplantation over a period of two years. Seventy one (46.71%) patients had culture positive UTI, Escherichia coli (45.1%) being the commonest. Thirty four (22.39%) patients had acute rejection and 14.4% of those had suffered UTI in the early post transplant period. Immunosuppression included induction with various antibodies and maintenance on antirejection medications. Trimethoprim-sulphamethoxazole was given as prophylaxis throughout the period. The UTI was treated according to microbiological sensitivity. 2.8% died due to urosepsis. In our retrospective analysis renal transplant recipients under the age of 45, female gender and diabetics suffered more UTI. Combination therapy with micro-emulsion form of cyclosporine A, prednisolone and azathioprine developed more UTI (P= 0.0418).
authors.affiliation: Pondicherry Institute of Medical Sciences, Madras Medical Mission, Chennai, India.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Khanna
authors.forename: Georgi
authors.initials: G
authors.lastname: Abraham
authors.forename: Asik Ali
authors.initials: AA
authors.lastname: Mohamed Ali
authors.forename: Prathiba Evelyn
authors.initials: PE
authors.lastname: Miriam
authors.forename: Milly
authors.initials: M
authors.lastname: Mathew
authors.forename: M K
authors.initials: MK
authors.lastname: Lalitha
authors.forename: Nancy
authors.initials: N
authors.lastname: Lesley
mesh_terms: D000328:Adult; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D016009:Chi-Square Distribution; D003920:Diabetes Mellitus / Q000453:epidemiology; D004359:Drug Therapy, Combination; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D007194:India / Q000453:epidemiology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents