title: Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.
abstract: BACKGROUND
  Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification.
  
  
  METHODS
  Horizon 1 of the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Study was conceived to apply emerging molecular techniques to existing data sets to characterize mechanistic diversity underlying complex human diseases, response to therapy, and prognosis. No previous studies have applied multiple, complementary molecular techniques in combination with well-developed clinical risk models to refine cardiovascular risk prediction. The MURDOCK Cardiovascular Disease Study will assess molecular profiles integrated with clinical data in "clinomic" profiles for cardiovascular risk classification.
  
  
  CONCLUSIONS
  Herein, we describe the design of and rationale for the MURDOCK Cardiovascular Disease Study.
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Svati H
authors.initials: SH
authors.lastname: Shah
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Granger
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Hauser
authors.forename: William E
authors.initials: WE
authors.lastname: Kraus
authors.forename: Jie-Lena
authors.initials: JL
authors.lastname: Sun
authors.forename: Karen
authors.initials: K
authors.lastname: Pieper
authors.forename: Charlotte L
authors.initials: CL
authors.lastname: Nelson
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Delong
authors.forename: Robert M
authors.initials: RM
authors.lastname: Califf
authors.forename: L Kristin
authors.initials: LK
authors.lastname: Newby
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D009657:North Carolina; D018579:Patient Selection; D057285:Precision Medicine; D016016:Proportional Hazards Models; D012107:Research Design; D018570:Risk Assessment / Q000145:classification*