Severe peripheral neuropathy following HAART initiation in an HIV-infected patient with leprosy.
We report a case of peripheral neuropathy following highly active antiretroviral therapy (HAART) initiation in a patient coinfected with HIV and Mycobacterium leprae and review the literature on leprosy-associated immune reconstitution inflammatory syndrome (IRIS). Physicians in charge of HIV-infected patients originating from countries endemic for leprosy should be aware of this risk of leprosy-associated IRIS when starting HAART.
Pavie
Juliette
J
Department of Infectious Diseases, Saint Louis Hospital and University of Paris Diderot, Paris, France. juliette.pavie@sls.aphp.fr
De Castro
Nathalie
N
Molina
Jean-Michel
JM
Flageul
Beatrice
B
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000382:microbiology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000209:etiology; D007918:Leprosy / Q000150:complications* / Q000382:microbiology; D008297:Male; D009166:Mycobacterium leprae; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index