Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link.
Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.
Conroy
H
H
Conway Institute for Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.
Mawhinney
L
L
Donnelly
S C
SC
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D015687:Cell Hypoxia / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000098:blood supply / Q000209:etiology* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000209:etiology
D015415:Biomarkers; D008263:Macrophage Migration-Inhibitory Factors
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