title: Clinical impact of a highly prevalent Pseudomonas aeruginosa clone in Dutch cystic fibrosis patients.
abstract: Studies suggest that infection with highly prevalent Pseudomonas aeruginosa clones in cystic fibrosis (CF) is associated with an unfavourable clinical outcome. We studied the clinical characteristics of patients infected with a recently described, highly prevalent P. aeruginosa clone (ST406) in two CF centres in The Netherlands. Multilocus sequence typing data were available for 219 patients, of whom 40 (18.3%) were infected with ST406 and 179 with other sequence types. ST406 infection was independently associated with age, having a sibling with ST406 infection and use of inhaled antibiotics, but not with unfavourable clinical outcome, suggesting that high transmissibility is not necessarily associated with high virulence.
authors.affiliation: Department of Paediatric Respiratory Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands. a.m.m.devrankrijker@umcutrecht.nl
authors.forename: A M M
authors.initials: AM
authors.lastname: de Vrankrijker
authors.forename: R W
authors.initials: RW
authors.lastname: Brimicombe
authors.forename: T F W
authors.initials: TF
authors.lastname: Wolfs
authors.forename: H G M
authors.initials: HG
authors.lastname: Heijerman
authors.forename: R
authors.initials: R
authors.lastname: van Mansfeld
authors.forename: F T
authors.initials: FT
authors.lastname: van Berkhout
authors.forename: R J L
authors.initials: RJ
authors.lastname: Willems
authors.forename: M J M
authors.initials: MJ
authors.lastname: Bonten
authors.forename: C K
authors.initials: CK
authors.lastname: van der Ent
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D058885:Multilocus Sequence Typing; D009426:Netherlands / Q000453:epidemiology; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000235:genetics*; D035781:Siblings; D055815:Young Adult