Serum albumin and biomolecular oxidative damage of human atherosclerotic plaques.
OBJECTIVE
To investigate the association of serum albumin (SA) with oxidative damage of human atherosclerotic plaques and the severity of atherosclerosis.


METHODS
Correlation of the levels of SA with those of lipid and protein oxidation of endarterectomy-removed carotid atherosclerotic plaques; SA and plaque oxidative biomarkers comparison between 2 groups of patients with different severity of atherosclerotic carotid stenosis, i.e. <90% (group I) or ≥90% (group II).


RESULTS
SA was strongly inversely correlated with plaque oxidative damage; SA was lower and plaque oxidative damage higher in group II than group I.


CONCLUSIONS
Lowered SA is associated with oxidative damage of atherosclerotic plaques and the severity of atherosclerosis.
Lapenna
Domenico
D
Dipartimento di Medicina e Scienze dell'Invecchiamento, Università G. d'Annunzio, Italy. dlapenna@unich.it
Ciofani
Giuliano
G
Ucchino
Sante
S
Pierdomenico
Sante Donato
SD
Cuccurullo
Chiara
C
Giamberardino
Maria Adele
MA
Cuccurullo
Franco
F
D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000473:pathology*; D012709:Serum Albumin / Q000378:metabolism*
D015415:Biomarkers; D012709:Serum Albumin