[A case of acute cerebellar ataxia associated with serum anti-NH2 terminal of alpha-enolase (NAE) antibody].
We reported a 61-year-old man who had developed acute cerebellar ataxia in the trunk and the lower limbs. His chemical blood analysis showed very mild hypothyroidism and the presence of serum anti-thyroid peroxidase (TPO) antibody and anti-NH2 terminal of alpha-enolase (NAE) antibody. While cerebellar atrophy was not evident on magnetic resonance imaging (MRI) of the brain, 99mTc-ECD SPECT using the easy Z-score imaging system (eZIS) showed decreased regional cerebral blood flow (rCBF) in the vermis of cerebellum. His cerebellar ataxia improved spontaneously within three weeks. The present case is very rare and suggests that anti-NAE autoantibody may be associated with actue cerebellar ataxia.
Yamamoto
Mikie
M
Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University.
Wada-Isoe
Kenji
K
Yoneda
Makoto
M
Doi
Koji
K
Kowa
Hisanori
H
Nakashima
Kenji
K
D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002524:Cerebellar Ataxia / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D010751:Phosphopyruvate Hydratase