title: Comprehensive investigation of three-dimensional diffuse optical tomography with depth compensation algorithm.
abstract: A depth compensation algorithm (DCA) can effectively improve the depth localization of diffuse optical tomography (DOT) by compensating the exponentially decreased sensitivity in the deep tissue. In this study, DCA is investigated based on computer simulations, tissue phantom experiments, and human brain imaging. The simulations show that DCA can largely improve the spatial resolution of DOT in addition to the depth localization, and DCA is also effective for multispectral DOT with a wide range of optical properties in the background tissue. The laboratory phantom experiment demonstrates that DCA can effectively differentiate two embedded objects at different depths in the medium. DCA is further validated by human brain imaging using a finger-tapping task. To our knowledge, this is the first demonstration to show that DCA is capable of accurately localizing cortical activations in the human brain in three dimensions.
authors.affiliation: University of Texas at Arlington, Department of Bioengineering, Arlington, Texas 76019, USA.
authors.forename: Haijing
authors.initials: H
authors.lastname: Niu
authors.forename: Zi-Jing
authors.initials: ZJ
authors.lastname: Lin
authors.forename: Fenghua
authors.initials: F
authors.lastname: Tian
authors.forename: Sameer
authors.initials: S
authors.lastname: Dhamne
authors.forename: Hanli
authors.initials: H
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*
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