title: Macrolides of the bafilomycin family produced by Streptomyces sp. CS.
abstract: Five new 16-membered macrolides (1-5), belonging to the bafilomycin subfamily, were isolated from the fermentation broth of Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. Their structures including relative configurations were elucidated based on NMR data and analysis of single crystal X-ray diffraction data. The cytotoxicities of compounds 1-5 on the MDA-MB-435 cell line were analyzed by the MTT method and the IC(50) values were found to be 4.2, 4.5, 5.5, 3.8 and 11.4 μM, respectively.
authors.affiliation: Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D000903:Antibiotics, Antineoplastic; D018942:Macrolides