title: Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women.
abstract: BACKGROUND
  Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.
  
  
  METHODS
  Cross-sectional study of 824 (218 HIV-negative, 606 HIV+) Rwandan women. Body composition by body impedance analysis, CD4 count, and fasting serum total cholesterol (total-C), triglycerides (TG) and high-density lipoprotein (HDL) levels were measured. Low-density lipoprotein (LDL) was calculated from Friedewald equation if TG < 400 and measured directly if TG ≥ 400 mg/dl.
  
  
  RESULTS
  BMI was similar in HIV+ and -negative women, < 1% were diabetic, and HIV+ women were younger. In multivariate models LDL was not associated with HIV-serostatus. HDL was lower in HIV+ women (44 vs. 54 mg/dL, p < 0.0001) with no significant difference by CD4 count (p = 0.13). HIV serostatus (p = 0.005) and among HIV+ women lower CD4 count (p = 0.04) were associated with higher TG. BMI was independently associated with higher LDL (p = 0.01), and higher total body fat was strongly associated with higher total-C and LDL. Framingham risk scores were < 2% in both groups.
  
  
  CONCLUSIONS
  In this cohort of non-obese African women HDL and TG, but not LDL, were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular (CV) events in women, this HIV-associated difference may confer increased risk for CV disease in HIV-infected women.
authors.affiliation: Montefiore Medical Center, Bronx NY, USA. kanastos@verizon.net.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: François
authors.initials: F
authors.lastname: Ndamage
authors.forename: Dalian
authors.initials: D
authors.lastname: Lu
authors.forename: Mardge H
authors.initials: MH
authors.lastname: Cohen
authors.forename: Qiuhu
authors.initials: Q
authors.lastname: Shi
authors.forename: Jason
authors.initials: J
authors.lastname: Lazar
authors.forename: Venerand
authors.initials: V
authors.lastname: Bigirimana
authors.forename: Eugene
authors.initials: E
authors.lastname: Mutimura
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