title: Condylar lesions in relation to mandibular growth in untreated and intra-articular corticosteroid-treated experimental temporomandibular joint arthritis.
abstract: OBJECTIVE
  To evaluate condylar lesions in relation to mandibular growth in experimental temporomandibular joint (TMJ) arthritis and to assess the outcome of treating this condition with repeated intra-articular corticosteroid injections (IACIs).
  
  
  METHODS
  Forty-two 10-week-old rabbits were randomly divided into four groups. Seven animals served as controls. Experimental TMJ arthritis was induced in five animals which received intra-articular TMJ saline injections. Fifteen animals had TMJ arthritis induced and were left untreated and 15 animals had TMJ arthritis induced and were treated with IACIs one week after each TMJ antigen-challenge procedure. Inter-group growth differences were evaluated from head computerised tomography scans taken at the time of arthritis induction and 12 weeks later. The variables assessed were: progression of condylar lesions (erosions/flattening/osteophytes), mandibular bone volume changes, condylar and sagittal ramus growth.
  
  
  RESULTS
  No inter-group differences in the progression of condylar lesions were observed despite reduced mandibular growth in all three experimental groups. The most pronounced unfavourable mandibular growth alterations were observed in the corticosteroid-treated arthritis animals.
  
  
  CONCLUSIONS
  No evidence was found in support of a relation between reduced mandibular growth and condylar lesions. We propose that: 1) condylar lesions are not the only causative factor of reduced mandibular growth in experimental TMJ arthritis, and 2) repeated IACIs have a very unfavourable impact on mandibular growth in experimental TMJ arthritis - treatment is more detrimental to mandibular growth than the TMJ arthritis itself.
authors.affiliation: Department of Orthodontics, University of Aarhus, Denmark. pstoustrup@odont.au.dk.
authors.forename: P
authors.initials: P
authors.lastname: Stoustrup
authors.forename: K D
authors.initials: KD
authors.lastname: Kristensen
authors.forename: A
authors.initials: A
authors.lastname: Küseler
authors.forename: J
authors.initials: J
authors.lastname: Gelineck
authors.forename: P M
authors.initials: PM
authors.lastname: Cattaneo
authors.forename: T K
authors.initials: TK
authors.lastname: Pedersen
authors.forename: T
authors.initials: T
authors.lastname: Herlin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D007270:Injections, Intra-Articular; D008334:Mandible / Q000000981:diagnostic imaging / Q000254:growth & development*; D008335:Mandibular Condyle / Q000000981:diagnostic imaging / Q000473:pathology*; D011817:Rabbits; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones