Monocyte and macrophage heterogeneity and Toll-like receptors in the lung.
Mononuclear phagocytes are crucial components of the innate host defense system. Cells such as macrophages and monocytes phagocytose and process pathogens, produce inflammatory mediators, and link the innate and the adaptive immune systems. The role of innate immune receptors such as Toll-like receptors (TLRs) in the recognition of pathogens is critical for mounting a precise and targeted immune response. This review focuses attention on the development of monocytes and macrophages, various populations of macrophages, and the expression and function of TLRs on macrophages.
Schneberger
David
D
Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada.
Aharonson-Raz
Karin
K
Singh
Baljit
B
D000818:Animals; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000276:immunology*; D008264:Macrophages / Q000166:cytology / Q000276:immunology*; D008954:Models, Biological; D009000:Monocytes / Q000166:cytology / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*
D051193:Toll-Like Receptors