Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma.
BACKGROUND
Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma.


METHODS
Seventy-eight patients with primarily resected esophageal squamous cell carcinoma were enrolled onto this study, and gp96 expression was evaluated by immunohistochemical staining. The association of clinicopathological factors and patients' survival was calculated by univariate (log rank test) and multivariate (Cox proportional hazard regression method) analyses.


RESULTS
Fifty-seven (73%) of 78 cases were gp96 positive, and 21 were negative (27%). The survival of patients with gp96-negative disease was significantly shorter (5-year survival, 22.9 months) than with gp96-positive disease (45.8 months; P = 0.049), and the multivariate analysis showed that gp96 negativity is an independent risk factor for poor survival (hazard ratio, 2.577; P = 0.040). Gp96-negative cases had more metastatic lymph nodes than did negative cases, especially in T1 cases (4.8 in gp96-negative cases vs. 0.84 in gp96-positive cases; P = 0.064)


CONCLUSIONS
The downregulation of gp96 expression is closely correlated with poor survival in esophageal squamous cell carcinoma.
Akutsu
Yasunori
Y
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. yakutsu@faculty.chiba-u.jp
Matsubara
Hisahiro
H
Kano
Masayuki
M
Usui
Akihiro
A
Yoneyama
Yasuo
Y
Ikeda
Norimasa
N
Komatsu
Aki
A
Yusup
Gulbostan
G
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
D008562:Membrane Glycoproteins; C053387:endoplasmin