Quercetin prevents unloading-derived disused muscle atrophy by attenuating the induction of ubiquitin ligases in tail-suspension mice.
The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.
Mukai
Rie
R
Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan.
Nakao
Reiko
R
Yamamoto
Hironori
H
Nikawa
Takeshi
T
Takeda
Eiji
E
Terao
Junji
J
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology; D019417:Hindlimb Suspension; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D018482:Muscle, Skeletal / Q000187:drug effects; D009133:Muscular Atrophy / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D011407:Propane / Q000031:analogs & derivatives / Q000494:pharmacology; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D044767:Ubiquitin-Protein Ligases / Q000187:drug effects*
D000975:Antioxidants; D047309:Flavones; D017392:Thiobarbituric Acid Reactive Substances; C022168:1,1,3,3-tetraethoxypropane; D011794:Quercetin; D044767:Ubiquitin-Protein Ligases; D011407:Propane; D000111:Acetylcysteine