Influence of previous abortions and new paternity on the risk of hypertension in nulliparous parturients in Ibadan: a cohort study.
OBJECTIVE
This study aims to determine the influence of previous abortions and new paternity on the risk of hypertension in a cohort of nulliparous women.


METHODS
A prospective cohort study was conducted with development of hypertension in pregnancy as outcome variable. Explanatory variables were previous abortions and paternity. Univariate analysis was by t-test, χ(2) test and Fisher's exact test where applicable. Logistic regression was utilized for multivariate analysis. Stata was utilized for all the analyses. The level of statistical significance was set as P < 0.05.


RESULTS
Same paternity abortions reduced the risk of hypertension (OR 0.48, 95% CI 0.31-0.73). Previous abortions did not reduce the odds of hypertension in pregnancy (OR 1.25, 95% CI 0.83-1.88). Rural dwelling reduced the odds of developing hypertension in pregnancy (OR 0.54, 95% CI 0.42-0.70).


CONCLUSIONS
The result of this study supports the immunological theory of the etiology of hypertension in pregnancy.
Olayemi
Oladapo
O
Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Nigeria. oladapo.olayemi@yahoo.com
Strobino
Donna
D
Adedapo
Kayode
K
Aimakhu
Christopher
C
Odukogbe
Akin-Tunde
AT
Salako
Babatunde
B
D000028:Abortion, Induced / Q000009:adverse effects*; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology*; D016015:Logistic Models; D009549:Nigeria; D016017:Odds Ratio; D010298:Parity; D010334:Paternity; D011247:Pregnancy; D012307:Risk Factors