CD62L(high) Treg cells with superior immunosuppressive properties accumulate within the CNS during remissions of EAE.
The role of regulatory T cell populations within the CNS in the regulation of CNS-autoimmunity is controversial. We show that during recovery from relapsing remitting experimental autoimmune encephalomyelitis, regulatory T cells accumulate within the CNS that express high levels of CD62L. These CD62L(high) Treg cells express increased amounts of CTLA-4, ICOS and TGF-β and are more potent than CD62L(low) Treg cells in suppressing proliferation and inducing apoptosis in effector T cells. CD62L(high) Treg cells thus represent a population of Treg cells that display superior immunosuppressive properties and accumulate in the CNS during recovery from CNS-autoimmunity.
Lange
Christian
C
Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany.
Scholl
Matthias
M
Melms
Arthur
A
Bischof
Felix
F
D000818:Animals; D017304:Annexin A5 / Q000378:metabolism; D015703:Antigens, CD / Q000096:biosynthesis; D017209:Apoptosis / Q000187:drug effects; D060908:CTLA-4 Antigen; D053148:Caspase 3 / Q000378:metabolism; D002490:Central Nervous System / Q000166:cytology* / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D007114:Immunization; D007165:Immunosuppression Therapy; D060945:Inducible T-Cell Co-Stimulator Ligand; D019041:L-Selectin / Q000378:metabolism*; D051379:Mice; D018991:Myelin Proteolipid Protein / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000235:genetics
D017304:Annexin A5; D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556707:Ctla4 protein, mouse; C400230:Icosl protein, mouse; D060945:Inducible T-Cell Co-Stimulator Ligand; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments; D011506:Proteins; D016212:Transforming Growth Factor beta; C435023:myelin proteolipid protein (139-151); D019041:L-Selectin; D053148:Caspase 3