Anti-asthmatic effects of an Amomum compactum extract on an ovalbumin (OVA)-induced murine asthma model.
Despite ongoing intensive asthma research, the incidence of asthma is increasing worldwide. We investigated in this study the effects of Amomum compactum on ovalbumin (OVA)-induced asthma in a mouse model, and studied the possible mechanism for its anti-asthmatic action. Our data show that an A. compactum treatment markedly decreased the number of infiltrating eosinophils and the hypersecretion of mucus when compared with the effects on mice treated with OVA alone. The A. compactum treatment dose-dependently decreased the levels of reactive oxygen species (ROS) and T helper (Th)2 cytokines, including interleukin (IL)-4 and IL-5, in the bronchoalveolar lavage fluid (BALF), and a high dose of A. compactum effectively reduced the level of total immunoglobulin (Ig)E in the serum. Taken together, these data indicate that the administration of A. compactum may have potential therapeutic value when used as an adjuvant for the immunomodulatory treatment of allergic asthma.
Lee
Jin-Ah
JA
Herbal Medicine Evidence Based Medicine Research Center, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Lee
Mee-Young
MY
Seo
Chang-Seob
CS
Jung
Da Young
DY
Lee
Nam-Hun
NH
Kim
Jung-Hun
JH
Ha
Hyekyung
H
Shin
Hyeun Kyoo
HK
D035801:Amomum / Q000737:chemistry*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000187:drug effects; D007073:Immunoglobulin E / Q000097:blood; D007155:Immunologic Factors; D051379:Mice; D009093:Mucus / Q000187:drug effects / Q000378:metabolism; D010047:Ovalbumin / Q000009:adverse effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D017382:Reactive Oxygen Species / Q000032:analysis; D018418:Th2 Cells / Q000276:immunology
D007155:Immunologic Factors; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D007073:Immunoglobulin E; D010047:Ovalbumin