title: Nitric oxide enhancement and blood pressure decrease in patients with metabolic syndrome using soy protein or fish oil.
abstract: OBJECTIVE
  To verify the effects of fish oil and soy on nitric oxide (NO) and blood pressure in patients with metabolic syndrome (MS).
  
  
  METHODS
  Sixty women with MS were investigated in a parallel randomized design study. The first group maintained their usual diet; the second group received 25 g/day of soy; the third group received 3 g/day of n-3 fatty acids, and the fourth group the same amount previously cited of n-3 fatty acids and soy.
  
  
  RESULTS
  Serum nitric oxide metabolites showed significant increase after 90 days in the fish oil and soy groups. Systolic pressure reduced after 45 days of treatment with fish oil, whereas diastolic pressure decreased significantly throughout the study in the soy group.
  
  
  CONCLUSIONS
  NO increase and blood pressure reduction with fish oil or soy protein reinforce the importance of the influence of NO on blood pressure in patients with MS.
authors.affiliation: Departamento de Patologia, Universidade Estadual de Londrina, PR, Brazil.
authors.forename: Andréa Name Colado
authors.initials: AN
authors.lastname: Simão
authors.forename: Marcell Alysson Batisti
authors.initials: MA
authors.lastname: Lozovoy
authors.forename: Tathiana Name Colado
authors.initials: TN
authors.lastname: Simão
authors.forename: Jane Bandeira
authors.initials: JB
authors.lastname: Dichi
authors.forename: Tiemi
authors.initials: T
authors.lastname: Matsuo
authors.forename: Isaias
authors.initials: I
authors.lastname: Dichi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000628:therapy; D007529:Isoflavones / Q000494:pharmacology*; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000503:physiopathology; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D030262:Soybean Proteins / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D005395:Fish Oils; D007529:Isoflavones; D030262:Soybean Proteins; D009569:Nitric Oxide