title: Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome.
abstract: OBJECTIVE
  To investigate the differences in depressive mood and quality of life in patients with between functional dyspepsia (FD), irritable bowel syndrome (IBS), and FD-IBS overlap as diagnosed based on Rome III criteria.
  
  
  METHODS
  The subjects completed a questionnaire based on Rome III criteria, the Beck Depressive Inventory (BDI) including Cognitive Depression Index (CDI) for depressive mood evaluation and the 36-item Short Form general health survey (SF-36) for quality of life assessment. Upper gastrointestinal endoscopy and colonoscopy were performed to exclude organic disease.
  
  
  RESULTS
  Of 279 subjects, 70 and 124 subjects were diagnosed as FD and IBS, respectively. FD-IBS overlap patients (n=42) and FD alone patients (n=28) showed higher BDI scores than normal subjects (n=127) (P<.001 and P=.02, respectively), whereas that of IBS alone patients (n=82) did not show difference (P=.17). All the SF-36 subscores of the FD-IBS overlap patients were significantly lower than normal subjects (P<.05).
  
  
  CONCLUSIONS
  Depressive mood was significantly related to FD and FD-IBS overlap but not to IBS based on Rome III criteria. FD-IBS overlap patients have worse quality of life than FD-alone and IBS-alone patients.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Jeong Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Sung
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Choon Jo
authors.initials: CJ
authors.lastname: Jin
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Hiejin
authors.initials: H
authors.lastname: Yoon
authors.forename: Hoon Jai
authors.initials: HJ
authors.lastname: Chun
mesh_terms: D000328:Adult; D015897:Comorbidity; D003866:Depressive Disorder / Q000523:psychology*; D004415:Dyspepsia / Q000523:psychology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000523:psychology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires