title: Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study.
abstract: OBJECTIVE
  To examine the course of depression during the treatment of adolescents with depression who had recently attempted suicide.
  
  
  METHODS
  Adolescents (N = 124), ages 12 to 18 years, with a 90-day history of suicide attempt, a current diagnosis of depressive disorder (96.0% had major depressive disorder), and a Children's Depression Rating Scale-Revised (CDRS-R) score of 36 or higher, entered a 6-month treatment with antidepressant medication, cognitive-behavioral therapy focused on suicide prevention, or their combination (Comb), at five academic sites. Treatment assignment could be either random or chosen by study participants. Intent-to-treat, mixed effects regression models of depression and other relevant ratings were estimated. Improvement and remission rates were computed with the last observation carried forward.
  
  
  RESULTS
  Most patients (n = 104 or 84%) chose treatment assignment, and overall, three fourths (n = 93) received Comb. In Comb, CDRS-R declined from a baseline adjusted mean of 49.6 (SD 12.3) to 38.3 (8.0) at week 12 and to 27.0 (10.1) at week 24 (p < .0001), with a Clinical Global Impression -defined improvement rate of 58.0% at week 12 and 72.2% at week 24 and a remission (CDRS-R ≤ 28) rate of 32.5% at week 12 and 50.0% at week 24. The CDRS-R and the Scale for Suicidal Ideation scores were correlated at baseline (r = 0.43, p < .0001) and declined in parallel.
  
  
  CONCLUSIONS
  When vigorously treated with a combination of medication and psychotherapy, adolescents with depression who have recently attempted suicide show rates of improvement and remission of depression that seem comparable to those observed in nonsuicidal adolescents with depression.
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University. Electronic address: bvitiell@mail.nih.gov.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Vitiello
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: David A
authors.initials: DA
authors.lastname: Brent
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Laurence L
authors.initials: LL
authors.lastname: Greenhill
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Graham
authors.initials: G
authors.lastname: Emslie
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Karen
authors.initials: K
authors.lastname: Wells
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: John T
authors.initials: JT
authors.lastname: Walkup
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Barbara
authors.initials: B
authors.lastname: Stanley
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Oscar
authors.initials: O
authors.lastname: Bukstein
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Betsy D
authors.initials: BD
authors.lastname: Kennard
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Scott
authors.initials: S
authors.lastname: Compton
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Barbara
authors.initials: B
authors.lastname: Coffey
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Cwik
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Kelly
authors.initials: K
authors.lastname: Posner
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Ann
authors.initials: A
authors.lastname: Wagner
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: John S
authors.initials: JS
authors.lastname: March
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Mark
authors.initials: M
authors.lastname: Riddle
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Tina
authors.initials: T
authors.lastname: Goldstein
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: John
authors.initials: J
authors.lastname: Curry
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Lisa
authors.initials: L
authors.lastname: Capasso
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Taryn
authors.initials: T
authors.lastname: Mayes
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Sa
authors.initials: S
authors.lastname: Shen
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: S Sonia
authors.initials: SS
authors.lastname: Gugga
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: J Blake
authors.initials: JB
authors.lastname: Turner
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Shannon
authors.initials: S
authors.lastname: Barnett
authors.affiliation: Drs. Vitiello and Wagner are with the National Institute of Mental Health; Drs. Brent, Bukstein, and Goldstein, and Ms. Zelazny are with the University of Pittsburgh Western Psychiatnc Institute and Clinic; Drs. Greenhill Stanley, Posner, Shen, and Turner, and Ms. Gugga and Ms. Capasso are with the Columbia University-New York State Psychiatric Institute; Drs. Emslie and Kennard, and Ms. Mayes are with the University of Texas Southwestern Medical Center in Dallas; Drs. Wells, Compton, Curry, and March are with the Duke University Medical Center; Dr. Coffey is with the New York University Child Study Center; Drs. Walkup, Cwik, Barnett, and Riddle are with Johns Hopkins University.
authors.forename: Jamie
authors.initials: J
authors.lastname: Zelazny
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002648:Child; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D019263:Dysthymic Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D055502:Secondary Prevention; D013406:Suicide, Attempted / Q000517:prevention & control* / Q000523:psychology* / Q000706:statistics & numerical data
chemical_list: D000928:Antidepressive Agents