Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1.
A 22-year-old man diagnosed with neurofibromatosis-I was admitted to the neurology department because of progressive hemianopsia and chronic headache. Magnetic resonance imaging, magnetic resonance spectroscopy (MRS), and F-18 fluorocholine revealed a splenial mass with imaging features compatible with malignant astrocytoma. At follow-up examination, the sharp decrease in F-18 fluorocholine uptake and in choline/creatine ratio supported a conservative management. Molecular imaging of optic pathway gliomas may be a valuable tool in the selection of therapeutic options.
Roselli
Francesco
F
Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
Pisciotta
Nicola M
NM
Aniello
Maria S
MS
Niccoli-Asabella
Artor
A
Defazio
Giovanni
G
Livrea
Paolo
P
Rubini
Giuseppe
G
D001921:Brain / Q000000981:diagnostic imaging; D002794:Choline / Q000031:analogs & derivatives*; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009900:Optic Nerve; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult
C514960:fluorocholine; D002794:Choline