A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata.
An 80% acetone extract of Monarda punctata showed an inhibitory effect on lipase activity in isolated mouse plasma in vitro and carvacrol was obtained as the active constituent. It had an IC₅₀ value of 4.07 mM invitro and suppressed elevations in blood triacylglycerol levels in olive oil-loaded mice. Furthermore, from the whole plant, 22 compounds were isolated. Six monoterpene glycosides, a flavone glucuronide, and other known compounds were identified based on the results of spectroscopic analyses.
Yamada
Keiko
K
Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai 981-8558, Japan.
Murata
Toshihiro
T
Kobayashi
Kyoko
K
Miyase
Toshio
T
Yoshizaki
Fumihiko
F
D000818:Animals; D000081007:Cymenes; D004791:Enzyme Inhibitors / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047309:Flavones / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020719:Glucuronides / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008049:Lipase / Q000037:antagonists & inhibitors*; D051379:Mice; D015394:Molecular Structure; D031338:Monarda / Q000737:chemistry*; D039821:Monoterpenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular
D000081007:Cymenes; D004791:Enzyme Inhibitors; D047309:Flavones; D020719:Glucuronides; D006027:Glycosides; D039821:Monoterpenes; C554986:keshonin; C073316:carvacrol; D008049:Lipase