Autotransplantation of cryopreserved ovarian tissue in 12 women with chemotherapy-induced premature ovarian failure: the Danish experience.
OBJECTIVE
To describe a cohort of 12 Danish women who received autotransplantation of frozen-thawed cryopreserved ovarian tissue because of premature ovarian failure after cancer treatment.


METHODS
Retrospective study.


METHODS
University hospitals.


METHODS
Twelve women with autotransplanted frozen-thawed ovarian tissue.


METHODS
Monitoring of hormonal parameters and results of 56 IVF cycles in 10 women.


METHODS
Levels of gonadotropins and sex steroids, functional life span of the grafts, and results of IVF.


RESULTS
All 12 women regained ovarian function between 8 and 26 weeks (mean 19 weeks) after transplantation. Ten women underwent a total of 56 IVF cycles, 76 follicles developed, 49 oocytes were aspirated, 18 were fertilized, and 16 embryos were transferred resulting in six pregnancies: two biochemical, one clinical that miscarried in week 7, and two ongoing resulting in the delivery of two healthy infants born at term to two women. One of these women subsequently conceived spontaneously and delivered another healthy infant. The life span of the transplanted tissue has been between 6 months and still functioning after 54 months.


CONCLUSIONS
Autotransplantation consistently leads to recovery of ovarian function after treatment-induced ovarian failure. Four women became pregnant, after IVF or spontaneously, resulting in the delivery of three healthy infants.
Schmidt
Kirsten Tryde
KT
The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. kirsten.tryde.schmidt@rh.regionh.dk
Rosendahl
Mikkel
M
Ernst
Erik
E
Loft
Anne
A
Andersen
Anders Nyboe
AN
Dueholm
Margit
M
Ottosen
Christian
C
Andersen
Claus Yding
CY
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015925:Cryopreservation; D003718:Denmark; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000534:rehabilitation / Q000628:therapy; D009369:Neoplasms / Q000188:drug therapy / Q000534:rehabilitation; D010053:Ovary / Q000502:physiology / Q000637:transplantation*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced* / Q000534:rehabilitation / Q000628:therapy*; D020127:Recovery of Function; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D055815:Young Adult
D000970:Antineoplastic Agents