From a global view to focused examination: understanding cellular function of lipid kinase VPS34-Beclin 1 complex in autophagy.
Phosphoinositide 3 kinase Class III (PIK3C3) or VPS34-Beclin 1 complex plays a key role in the autophagy-lysosome pathway. Previous identification of numerous binding partners for VPS34-Beclin 1 suggested a complex scheme of the autophagy control mechanism. Recent large-scale screening of autophagy network and signaling pathways in mammalian cells not only confirms the previous binding partners, but also reveals additional interactors and intricate connections of VPS34-Beclin 1 complex to other functional groups of autophagy, yielding a wealth of information that will direct future detailed study of the central control mechanism of autophagy mediated by VPS34-Beclin 1 and other regulators.
Yue
Zhenyu
Z
Department of Neurology & Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA. zhenyu.yue@mssm.edu
Zhong
Yun
Y
D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001343:Autophagy; D002460:Cell Line; D058546:Class III Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D040901:Proteomics; D015398:Signal Transduction
D051017:Apoptosis Regulatory Proteins; D058546:Class III Phosphatidylinositol 3-Kinases