title: Ulceration and antihypertensive use are risk factors for infection after skin lesion excision.
abstract: BACKGROUND
  A prospective audit was performed of wound complications of skin lesion excision in a private practice setting.
  
  
  METHODS
  For 924 consecutive skin lesion excisions performed by a single surgeon, information was collected on tumour size and site, closure method and on risk factors of age, known diabetes, use of steroids, antihypertensives or anticoagulants and ulceration of the lesion. Patients were given written instructions to wet the wound in the shower after one or two days. A wound 'infection' event was recorded if the wound appeared inflamed or if the patient had been treated with antibiotics by any practitioner. Wound bleeding was recorded if the patient returned or attended elsewhere for management of bleeding.
  
  
  RESULTS
  Sixty-seven wounds (7.25%) met the broad definition of 'infection' and 18 (1.9%) wounds suffered bleeding. Ulceration (odds ratio (OR) 3.15, P= 0.008) and use of antihypertensives (OR 2.5, P= 0.006) were independent risk factors for infection along with site and closure method. The patients who did not wet their wounds post-operatively were also at an increased risk of infection (OR 2.1, P= 0.018). Aspirin caused a slight, non-statistically significant increase in bleeding rate, and warfarin caused a larger, but still not statistically significant, increase in bleeding. Use of other anticoagulants caused a significant increase in bleeding (OR 10.9, P= 0.006).
  
  
  CONCLUSIONS
  Ulceration of the skin lesion and use of antihypertensives are significant risk factors for wound infection. Wetting surgical wounds with clean tap water does not increase, and may even reduce, wound infection rate.
authors.affiliation: University of Melbourne Department of Surgery, St Vincent's Hospital, Fitzroy, Victoria, Australia. a.penington@unimelb.edu.au
authors.forename: Anthony
authors.initials: A
authors.lastname: Penington
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001315:Australia / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D015994:Incidence; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000601:surgery*; D012883:Skin Ulcer / Q000150:complications* / Q000453:epidemiology; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology*
chemical_list: D000959:Antihypertensive Agents