[Preoperative management of malignant hyperthermia].
Malignant hyperthermia (MH) is a potentially fatal complication of general anesthesia following exposure to a depolarizing muscle relaxant and/or volatile anesthetics. MH is inherited as autosomal dominant and is thought to result from disordered Ca2+ regulation by the sarcoplasmic reticulum of the skeletal muscle. The mortality is still approximately 15% in Japan. It is difficult to diagnose by usual examinations preoperatively. Therefore, early detection, prompt treatment, discontinuation of triggering agents, and sufficient administration of dantrolene are needed.
Migita
Takako
T
Department of Anesthesiology and Critical Care, Hiroshima University and Graduate School, Hiroshima 734-8551.
Kawamoto
Masashi
M
D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000628:therapy