title: Unusual form of superficial spreading squamous cell carcinoma of cervix involving the endometrium, bilateral tubes and ovaries: a case report with literature review.
abstract: OBJECTIVE
  Although the majority of metastatic ovarian tumors arise within the female genital tract, squamous cell carcinoma of the cervix is a rare form of metastases to the bilateral ovaries by endometrial and transtubal spreading.
  
  
  METHODS
  A 53-year-old woman was referred to the oncology clinic with postmenopausal bleeding. On vaginal examination, a 3 cm tumor arising from the cervix was inspected. Multiple cervical biopsies and endocervical curettage revealed large cell, non-keratinized squamous cell cervix carcinoma. Radical hysterectomy and bilateral salpingo-oophorectomy were performed. Bilateral pelvic and para-aortic lymph nodes were also removed. The final pathology report revealed endometrial, focal myometrial, bilateral tubal mucosal, fimbrial and bilateral ovarian squamous cell carcinoma involvement. Pelvic and para-aortic nodes were free from metastases.
  
  
  CONCLUSIONS
  Although the incidence of ovarian metastases of adenocarcinoma of the cervix is significantly higher, squamous cell carcinoma may also metastasize to the ovaries by endometrial and transtubal spreading in the absence of lymph node involvement. Especially in young patients for whom preservation of the ovaries is supposed, gross intraoperative inspection of the radical hysterectomy specimen and endometrium should be done and ovaries should be evaluated carefully.
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Zekai Tahir Burak Kadin Sagligi Egitim ve Arastirma Hastanesi Cebeci, Ankara, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
authors.forename: Sunduz Ozlem
authors.initials: SO
authors.lastname: Altinkaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozat
authors.forename: Serap
authors.initials: S
authors.lastname: Akbay
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary*; D016889:Endometrial Neoplasms / Q000556:secondary*; D005185:Fallopian Tube Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000556:secondary*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*