title: A convenient synthesis of 13N-labelled azo compounds: a new route for the preparation of amyloid imaging PET probes.
abstract: In the present paper, a fast and automated method for the synthesis of (13)N-labelled azo compounds is reported for the first time. The labelling strategy is based on trapping [(13)N]NO(2)(-) in an anion exchange resin. The reaction with primary aromatic amines in acidic media led to the formation of the corresponding diazonium salts, which were further reacted with aromatic amines and alcohols to yield the corresponding (13)N-labelled azo derivatives with good radiochemical conversion (40.0-58.3%). Good radiochemical yields (20.4-47.2%, decay corrected) and radiochemical purities (>99.9%) were obtained after purification by HPLC. Such methodology can be easily applied to the preparation of a wide range of (13)N-labelled azo derivatives by adequate selection of the non-radioactive precursors.
authors.affiliation: Radiochemistry Department, CIC biomaGUNE, Parque Tecnológico de San Sebastián, p° Miramón 182, 20009 San Sebastián, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gómez-Vallejo
authors.forename: José I
authors.initials: JI
authors.lastname: Borrell
authors.forename: Jordi
authors.initials: J
authors.lastname: Llop
mesh_terms: D000682:Amyloid / Q000032:analysis*; D001391:Azo Compounds / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D009590:Nitrogen Radioisotopes; D049268:Positron-Emission Tomography; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000682:Amyloid; D001391:Azo Compounds; D009590:Nitrogen Radioisotopes