title: Three-dimensional morphometric analysis of the distal femur: a validity method for allograft selection using a virtual bone bank.
abstract: Tumor excision is the primary treatment of aggressive or recurrent benign bone tumors and malignant bone sarcomas. This requires a surgical resection with the potential for large residual osseous defects that could be reconstructed using fresh frozen allografts. Virtual bone banks enable the creation of databases allowing a 3D pre-surgery evaluation of such allgorafts, based on segmentation of DICOM-CT images. This study demonstrates the usefulness of patient specific 3D models for an accurate host-donor allograft match. We describe one way to select the best match according to size and shape. The results suggest that a robust and reliable technique has been established. Since it is difficult to plan an allograft on a distal femur deformed by the tumor, we propose to plan the surgery on the contralateral side. Our results support this limb symmetry hypothesis. The use of this measurement protocol enables accurate selection of allografts from a contralateral healthy femur 3D CT model achieving the best match possible considering the geometry of available allograft candidate femur specimens.
authors.affiliation: Department of Medical Informatics, Hospital Italiano de Buenos Aires, Argentina. lucas.rittaco@hospitalitaliano.org
authors.forename: Lucas Eduardo
authors.initials: LE
authors.lastname: Ritacco
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Espinoza Orías
authors.forename: Luis
authors.initials: L
authors.lastname: Aponte-Tinao
authors.forename: Domingo L
authors.initials: DL
authors.lastname: Muscolo
authors.forename: Fernan González Bernaldo
authors.initials: FG
authors.lastname: de Quirós
authors.forename: Inoue
authors.initials: I
authors.lastname: Nozomu
mesh_terms: D000293:Adolescent; D018586:Bone Banks / Q000592:standards; D016025:Bone Transplantation / Q000379:methods; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging* / Q000637:transplantation*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D009929:Organ Size; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous; D055815:Young Adult