title: Diffuse alveolar damage and recurrent respiratory failure secondary to sertraline.
abstract: Sertraline is one of the most commonly used antidepression medications. In this case report, we present a 52-year-old male, smoker, who presented with respiratory failure, 6 months after starting Sertraline. We noticed an improvement in the clinical course after decreasing the dose of Sertraline and recurrent respiratory failure upon inadvertent rechallenge. Open-lung biopsy showed a picture of diffuse alveolar damage. Eventually, the patient improved after stopping Sertraline. This case demonstrates the relation of a drug causing lung disease, after excluding other causes, dechallenge, and rechallenge, in support of radiological and histopathological picture of drug-induced lung injury.
authors.affiliation: Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
authors.forename: Nezam I
authors.initials: NI
authors.lastname: Torok
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Donaldson
authors.forename: Jamil
authors.initials: J
authors.lastname: Taji
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abugiazya
authors.forename: Ragheb
authors.initials: R
authors.lastname: Assaly
mesh_terms: D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000473:pathology; D012008:Recurrence; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000503:physiopathology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D020280:Sertraline / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline