Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity.
BACKGROUND
It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention. On this basis the aim of our study was to evaluate plasma levels of adiponectin, resistin and IL-6 in subjects with diabetic foot in comparison with subjects without foot complications.


METHODS
We recruited 34 subjects with type 2 diabetes mellitus and foot ulceration hospitalized for every condition related to diabetic disease, but not for new vascular events (group A). As controls we recruited 37 patients with type 2 diabetes mellitus without foot ulceration (group B) hospitalized for every condition related to diabetic disease, but not for new vascular events. Adiponectin, Resistin and IL-6 serum levels were evaluated.


RESULTS
Subjects of group A showed lower median plasma levels of adiponectin [7.7450 (4.47-12.17) μg/ml vs 8.480 (5.15-12.87) μg/ml], higher median plasma levels of IL-6 [3.21 (1.23-5.34) pg/ml vs 2.73 (1.24-3.97 pg/ml)] and of resistin [3.860 (2.96-6.29 ng/ml) vs 3.690 (2.,37-6.5 ng/ml)].


CONCLUSIONS
Our study demonstrated that diabetic subjects with diabetic foot showed in comparison with diabetics without diabetic foot higher IL-6 and resistin plasma levels, lower adiponectin plasma levels.
Tuttolomondo
Antonino
A
Dipartimento Biomedico di Medicina Interna e Specialistica Università degli Studi di Palermo, Italy. brunotutto@unipa.it
La Placa
Sergio
S
Di Raimondo
Domenico
D
Bellia
Chiara
C
Caruso
Antonietta
A
Lo Sasso
Bruna
B
Guercio
Giovanni
G
Diana
Giuseppe
G
Ciaccio
Marcello
M
Licata
Giuseppe
G
Pinto
Antonio
A
D052242:Adiponectin / Q000097:blood; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D017719:Diabetic Foot / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D052243:Resistin / Q000097:blood*
C499918:ADIPOQ protein, human; D052242:Adiponectin; C508600:IL6 protein, human; D015850:Interleukin-6; C499624:RETN protein, human; D052243:Resistin