Epigenetics and psychoneuroimmunology: mechanisms and models.
In this Introduction to the Named Series "Epigenetics, Brain, Behavior, and Immunity" an overview of epigenetics is provided with a consideration of the nature of epigenetic regulation including DNA methylation, histone modification and chromatin re-modeling. Illustrative examples of recent scientific developments are highlighted to demonstrate the influence of epigenetics in areas of research relevant to those who investigate phenomena within the scientific discipline of psychoneuroimmunology. These examples are presented in order to provide a perspective on how epigenetic analysis will add insight into the molecular processes that connect the brain with behavior, neuroendocrine responsivity and immune outcome.
Mathews
Herbert L
HL
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, 2160 South First Ave., Maywood, IL 60153, USA. hmathew@lumc.edu
Janusek
Linda Witek
LW
D000328:Adult; D002843:Chromatin / Q000235:genetics; D019175:DNA Methylation; D057890:Epigenomics; D005260:Female; D015894:Genome, Human / Q000276:immunology; D006657:Histones / Q000378:metabolism; D006801:Humans; D007109:Immunity / Q000235:genetics; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology; D011499:Protein Processing, Post-Translational; D011598:Psychoneuroimmunology; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D013315:Stress, Psychological / Q000276:immunology
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D012313:RNA