title: Reproducibility of near-infrared spectroscopy for the detection of lipid core coronary plaques and observed changes after coronary stent implantation.
abstract: OBJECTIVE
  To evaluate the reproducibility of catheter-based intracoronary near-infrared spectroscopy (NIRS) for the detection of lipid core coronary plaques (LCPs) and to examine stenting-induced changes in NIRS findings.
  
  
  BACKGROUND
  The in-vivo reproducibility of coronary NIRS findings and their changes after stenting have not previously been characterized.
  
  
  METHODS
  NIRS assessment using an automated pullback catheter was performed in duplicate in 36 vessels in 31 patients. The reproducibility of the Lipid Core Burden Index (LCBI) and the presence and number of LCPs was assessed. The changes in LCBI after stenting were also assessed in 25 vessels in 22 patients.
  
  
  RESULTS
  LCBI of the first and second pullback was 64 ± 43 and 70 ± 62, respectively, with excellent correlation (Spearman's rho 0.927, intraclass correlation coefficient 0.925). Depending on LCP definition, mean LCP length, and median LCP number ranged from 2.44 to 17.25 mm, and from 0 to 2, respectively per artery studied. High correlation was observed between the two pullbacks for total LCP length (depending on the LCP definition used, the Spearman's rho and the intraclass correlation coefficient ranged from 0.72 to 0.89, and from 0.76 to 0.91, respectively) and for LCP number (depending on the LCP definition used, the Spearman's rho and the intraclass correlation coefficient ranged from 0.70 to 0.87, and from 0.67 to 0.88, respectively). The mean LCBI decreased by 40% from 78 ± 47 to 48 ± 38 after stenting (P < 0.001).
  
  
  CONCLUSIONS
  The LCBI and LCP length NIRS measurements have high reproducibility. LCBI significantly decreases after coronary stenting.
authors.affiliation: Veteran Affairs North Texas Healthcare System, Dallas, TX, USA.
authors.forename: Bobby A
authors.initials: BA
authors.lastname: Garcia
authors.forename: Frances
authors.initials: F
authors.lastname: Wood
authors.forename: Daisha
authors.initials: D
authors.lastname: Cipher
authors.forename: Subhash
authors.initials: S
authors.lastname: Banerjee
authors.forename: Emmanouil S
authors.initials: ES
authors.lastname: Brilakis
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared; D015607:Stents; D013781:Texas; D016896:Treatment Outcome
chemical_list: D008055:Lipids