[Experimental study on selective hepatic lobectomy using nitinol alloy net blocker of biliary intrahepatic duct].
OBJECTIVE
To investigate the feasibility and possible mechanism of non traditional hepatic lobectomy using nitinol alloy net blocker of biliary intrahepatic duct.


METHODS
Biliary intrahepatic ducts of the experimental pigs were blocked with and without dissepiment blockers. The histological changes and expressions of TGF-betal and TIMP-1 in the livers were compared.


RESULTS
Blockage of biliary intrahepatic duct using nitinol alloy net blocker without dissepiment resulted in obvious atrophy of the focus liver. The mean weight and size of the focus liver was only 1/4 of the controls (P < 0.05), with liver cells almost completely taken by collagen fibers. Higher expressions of TGF-beta1 and TIMP-1 were found in the group without dissepiment than in the group with dissepiments (P < 0.05).


CONCLUSIONS
Using nitinol alloy net blocker for selective hepatic lobectomy is as effective as traditional hepatic lobectomy. It may offer a new way for treating intrahepatic bile duct stones.
Tan
Hong
H
Department of Hepatobiliary Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Xu
Jian-Min
JM
Xiong
Xian-Ze
XZ
Cheng
Nan-Sheng
NS
Wu
Liang-Hong
LH
Lin
Yi-Xi
YX
D000497:Alloys; D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D002780:Cholestasis, Intrahepatic / Q000628:therapy*; D003250:Constriction; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D008297:Male; D011897:Random Allocation; D013552:Swine
D000497:Alloys; C013616:nitinol