title: Genetic subtypes of HIV type 1 circulating in Slovakia.
abstract: Slovakia belongs to the group of European countries with a low prevalence of HIV infection. The major proportion of HIV-positive cases in Slovakia is still represented by MSM, followed by heterosexuals infected through unprotected sexual intercourse. This study was conducted to update the description of HIV subtypes circulating in Slovakia. HIV-1 partial pol gene sequences from 143 individuals were prospectively collected from 2004 to 2008 and analyzed. Phylogenetic analysis based on HIV-1 partial pol gene sequences revealed the highest prevalence of HIV-1 B subtype (93.0 %), predominantly associated with the MSM group. Ten (7.0%) individuals were infected with HIV-1 non-B subtypes. The pure subtypes were more frequent (7; 4.9%) than CRFs (3; 2.1%) and their occurrence was as follows: subtype C (3; 2, 1%), subtype A (2; 1.4%), subtype F (2; 1.4%), CRF_01AE (1; 0.7%), CRF_02AG (1; 0.7%), and CRF08_BC (1; 0.7%). Data show slightly increasing HIV-1 subtype diversity, with HIV-1 subtype B still having the highest prevalence in the Slovak-infected population.
authors.affiliation: Slovak Medical University, NRC for HIV/AIDS Prevention, Bratislava, Slovakia. monika.habekova@szu.sk
authors.forename: Monika
authors.initials: M
authors.lastname: Habekova
authors.forename: M
authors.initials: M
authors.lastname: Takacova
authors.forename: J
authors.initials: J
authors.lastname: Lysy
authors.forename: M
authors.initials: M
authors.lastname: Mokras
authors.forename: R
authors.initials: R
authors.lastname: Camacho
authors.forename: P
authors.initials: P
authors.lastname: Truska
authors.forename: D
authors.initials: D
authors.lastname: Stanekova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015751:Genes, pol; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D020010:Heterosexuality; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D018154:Slovakia / Q000453:epidemiology; D055815:Young Adult; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D012367:RNA, Viral; D054302:pol Gene Products, Human Immunodeficiency Virus