title: Short-term zoledronic acid reduces trabecular bone remodeling in dogs.
abstract: The effects of zoledronic acid, a bisphosphonate, on the trabecular bone remodeling (TBR) of the mandibular condyle are unknown. The objectives of this study were to quantify and compare TBR in the mandibular condyle and vertebrae of 2- to 3-yr-old dogs and to evaluate the effects of short-term zoledronic acid on TBR. Bone samples from two, age-matched groups of dogs [seven dogs were given no treatment (NT group) and seven dogs were treated with four total infusions of zoledronic acid administered monthly (ZOL group)] were analyzed using histomorphometry. Trabecular bone remodeling and microarchitecture were quantified and analyzed statistically. Physiologic TBR, quantified in the NT group, was significantly higher (more than sixfold) in the vertebrae than in the mandibular condyle. Trabecular bone remodeling in the vertebrae of dogs of the ZOL group was 96% lower than in dogs of the NT group. By contrast, TBR in the mandibular condyle of dogs in the ZOL group was statistically equivalent to that of dogs in the NT group. Our results demonstrate that the physiological TBR in aged dogs is vastly different in the mandibular condyle compared to that in the vertebra. A higher level of physiologic TBR in the vertebra than in the mandibular condyle results in greater reduction of TBR in response to short-term treatment with zoledronic acid.
authors.affiliation: Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Nathan B
authors.initials: NB
authors.lastname: Helm
authors.forename: Soumya
authors.initials: S
authors.lastname: Padala
authors.forename: F Michael
authors.initials: FM
authors.lastname: Beck
authors.forename: Andrew M
authors.initials: AM
authors.lastname: D'Atri
authors.forename: Sarandeep S
authors.initials: SS
authors.lastname: Huja
mesh_terms: D000375:Aging; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects*; D004164:Diphosphonates / Q000494:pharmacology*; D004285:Dogs; D007093:Imidazoles / Q000494:pharmacology*; D008159:Lumbar Vertebrae / Q000187:drug effects*; D008297:Male; D008335:Mandibular Condyle / Q000187:drug effects; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid