Oral vancomycin may have significant absorption in patients with Clostridium difficile colitis.
A patient on haemodialysis with bowel ischemia was given vancomycin 500 mg orally every 6 h for superimposed Clostridium difficile colitis resulting in a high vancomycin serum concentration. When treating C. difficile colitis in patients with significant renal impairment and bowel injury, we recommend administering the lower dose of oral vancomycin.
Chihara
Shingo
S
Department of Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, Japan. schihara@dokkyomed.ac.jp
Shimizu
Riha
R
Furukata
Satoshi
S
Hoshino
Koichi
K
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016360:Clostridioides difficile / Q000302:isolation & purification*; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D044967:Serum / Q000737:chemistry; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin