Gold(I)/Zn(II) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles.
The tandem hydroamination-annulation reaction of 4-pentyne-nitriles in the presence of amine nucleophiles and a cooperatively operating catalyst system, consisting of Ph(3)PAuCl and Zn(ClO(4))(2), provides an efficient route to 2-aminopyrroles. Two regioisomeric 2-aminopyrroles were formed in moderate to good yields.
Demir
Ayhan S
AS
Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey. asdemir@metu.edu.tr
Emrullahoğlu
Mustafa
M
Buran
Kerem
K