Water soluble nanoporous nanoparticle for in vivo targeted drug delivery and controlled release in B cells tumor context.
Multitasking nanoparticles are gaining great attention for smart drug delivery systems. The exploration of the nano-scale opens new concrete opportunities for revealing new properties and undiscovered cell-particle interactions. Here we present a biodegradable nanoporous silicon nanoparticle that can be successfully employed for in vivo targeted drug delivery and sustained release. The bare nanoporous nanocarriers can be accurately designed and fabricated with an effective control of porosity, surface chemistry and particle size, up to a few nm. The proposed nanoparticles exhibit several remarkable features including high payload, biodegradability, no toxicity, and multiple loading in water without the need of additional chemical reagents at room temperature. The targeting strategy is based on phage display technology that was successfully used to discover cell surface binding peptide for murine B lymphoma A20 cell line. The peptide used in combination with the nanoporous nanoparticles allows an efficient in vivo targeting, a sustained release and a sensible therapeutic effect.
De Angelis
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F
Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Pujia
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A
Falcone
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C
Iaccino
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E
Palmieri
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C
Liberale
C
C
Mecarini
F
F
Candeloro
P
P
Luberto
L
L
de Laurentiis
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A
Das
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Scala
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G
Di Fabrizio
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E
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D008807:Mice, Inbred BALB C; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*; D012995:Solubility; D014867:Water / Q000737:chemistry*
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D014867:Water