Revisiting the Kinnel-Scheuer hypothesis for the biosynthesis of palau'amine.
We propose herein an alternative biosynthetic pathway for palau'amine in order to resolve the stereochemical issue from the original Kinnel-Scheuer hypothesis. Furthermore, we use this revised hypothesis as a guide toward the laboratory synthesis of palau'amine.
Ma
Zhiqiang
Z
Department of Biochemistry, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA.
Lu
Jianming
J
Wang
Xiao
X
Chen
Chuo
C
D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010456:Peptides, Cyclic; C482752:palauamide