Type I interferon: friend or foe?
Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.
Trinchieri
Giorgio
G
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. trinchig@mail.nih.gov
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D012769:Shock / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
D007370:Interferon Type I; D007371:Interferon-gamma