title: A randomized prospective trial of airway pressure release ventilation and low tidal volume ventilation in adult trauma patients with acute respiratory failure.
abstract: BACKGROUND
  Airway pressure release ventilation (APRV) is a mode of mechanical ventilation, which has demonstrated potential benefits in trauma patients. We therefore sought to compare relevant pulmonary data and safety outcomes of this modality to the recommendations of the Adult Respiratory Distress Syndrome Network.
  
  
  METHODS
  Patients admitted after traumatic injury requiring mechanical ventilation were randomized under a 72-hour waiver of consent to a respiratory protocol for APRV or low tidal volume ventilation (LOVT). Data were collected regarding demographics, Injury Severity Score, oxygenation, ventilation, airway pressure, failure of modality, tracheostomy, ventilator-associated pneumonia, ventilator days, length of stay (LOS), pneumothorax, and mortality.
  
  
  RESULTS
  Sixty-three patients were enrolled during a 21-month period ending in February 2006. Thirty-one patients were assigned to APRV and 32 to LOVT. Patients were well matched for demographic variables with no differences between groups. Mean Acute Physiology and Chronic Health Evaluation II score was higher for APRV than LOVT (20.5 ± 5.35 vs. 16.9 ± 7.17) with a p value = 0.027. Outcome variables showed no differences between APRV and LOVT for ventilator days (10.49 days ± 7.23 days vs. 8.00 days ± 4.01 days), ICU LOS (16.47 days ± 12.83 days vs. 14.18 days ± 13.26 days), pneumothorax (0% vs. 3.1%), ventilator-associated pneumonia per patient (1.00 ± 0.86 vs. 0.56 ± 0.67), percent receiving tracheostomy (61.3% vs. 65.6%), percent failure of modality (12.9% vs. 15.6%), or percent mortality (6.45% vs. 6.25%).
  
  
  CONCLUSIONS
  For patients sustaining significant trauma requiring mechanical ventilation for greater than 72 hours, APRV seems to have a similar safety profile as the LOVT. Trends for APRV patients to have increased ventilator days, ICU LOS, and ventilator-associated pneumonia may be explained by initial worse physiologic derangement demonstrated by higher Acute Physiology and Chronic Health Evaluation II scores.
authors.affiliation: Department of Surgery, University of Tennessee College of Medicine, Chattanooga, Tennessee 37403, USA. Robert.Maxwell@universitysurgical.com
authors.forename: Robert A
authors.initials: RA
authors.lastname: Maxwell
authors.forename: John M
authors.initials: JM
authors.lastname: Green
authors.forename: Jimmy
authors.initials: J
authors.lastname: Waldrop
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Dart
authors.forename: Philip W
authors.initials: PW
authors.lastname: Smith
authors.forename: Donald
authors.initials: D
authors.lastname: Brooks
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Lewis
authors.forename: Donald E
authors.initials: DE
authors.lastname: Barker
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D013990:Tidal Volume; D013997:Time Factors; D016896:Treatment Outcome; D015300:Ventilator Weaning; D014947:Wounds and Injuries / Q000150:complications / Q000401:mortality / Q000628:therapy*