Claudin-11 expression increased in spermatogenic defect in human testes.
Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis.
Nah
Won Heum
WH
Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, South Korea.
Lee
Jae Eun
JE
Park
Hyun Jun
HJ
Park
Nam Cheol
NC
Gye
Myung Chan
MC
D000328:Adult; D000368:Aged; D001706:Biopsy; D002450:Cell Communication / Q000502:physiology; D057167:Claudins; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D012708:Sertoli Cells / Q000473:pathology / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology; D013737:Testis / Q000098:blood supply / Q000473:pathology / Q000502:physiology; D019108:Tight Junctions / Q000502:physiology
C120453:CLDN11 protein, human; D057167:Claudins; D009419:Nerve Tissue Proteins