title: Comparative in vitro activities of torezolid (DA-7157) against clinical isolates of aerobic and anaerobic bacteria in South Korea.
abstract: Resistance of Gram-positive pathogens to first-line antimicrobial agents has been increasing in many parts of the world. We compared the in vitro activities of torezolid with those of other antimicrobial agents, including linezolid, against clinical isolates of major aerobic and anaerobic bacteria. Torezolid had an MIC(90) of ≤0.5 μg/ml for the Gram-positive bacterial isolates tested and was more potent than either linezolid or vancomycin.
authors.affiliation: Department of Clinical Laboratory Science, Dong-eui University, Busan, South Korea.
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Yum
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Choi
authors.forename: Dongeun
authors.initials: D
authors.lastname: Yong
authors.forename: Yunsop
authors.initials: Y
authors.lastname: Chong
authors.forename: Weon Bin
authors.initials: WB
authors.lastname: Im
authors.forename: Dong-Kwon
authors.initials: DK
authors.lastname: Rhee
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
mesh_terms: D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D000069349:Linezolid; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology*; D056910:Republic of Korea; D013777:Tetrazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013777:Tetrazoles; C546016:tedizolid; D000069349:Linezolid