title: Life-saving decompressive craniectomy for diffuse cerebral edema during an episode of new-onset diabetic ketoacidosis: case report and review of the literature.
abstract: OBJECTIVE
  Diabetic ketoacidosis (DKA), a well-known complication of diabetes mellitus, is associated with severe diffuse cerebral edema leading to brain herniation and death. Survival from an episode of symptomatic cerebral edema has been associated with debilitating neurological sequelae, including motor deficits, visual impairment, memory loss, seizures, and persistent vegetative states. A review of the literature reveals scant information regarding the potential surgical options for these cases. The authors present their case in which they used a craniectomy to treat this life-threatening condition.
  
  
  METHODS
  After reportedly suffering nausea and vomiting, a 12-year-old male presented to the emergency room with lethargy and was diagnosed with acute DKA. After appropriate treatment, the patient became comatose. A CT scan revealed diffuse cerebral edema. To decrease intracranial pressure and prevent further progression of brain herniation, a bifrontal decompressive craniectomy with duraplasty was performed.
  
  
  RESULTS
  The patient's neurological function gradually improved, and he returned to school and his regular activities with only minimal cognitive deficits.
  
  
  CONCLUSIONS
  Given the high mortality and morbidity associated with DKA-related edema, we believe decompressive craniectomy should be considered for malignant cerebral edema and herniation syndrome.
authors.affiliation: Clarian Neuroscience, Goodman Campbell Brain and Spine, and Indiana University Department of Neurological Surgery, 1801 North Senate Blvd # 610, Indianapolis, IN, USA.
authors.forename: Ha Son
authors.initials: HS
authors.lastname: Nguyen
authors.forename: James D
authors.initials: JD
authors.lastname: Callahan
authors.forename: Aaron A
authors.initials: AA
authors.lastname: Cohen-Gadol
mesh_terms: D001929:Brain Edema / Q000209:etiology* / Q000601:surgery*; D002648:Child; D056424:Decompressive Craniectomy; D016883:Diabetic Ketoacidosis / Q000150:complications* / Q000601:surgery*; D006801:Humans; D008297:Male