title: High Dose Rate Brachytherapy in the Treatment of cervical cancer: preliminary experience with cobalt 60 Radionuclide source-A Prospective Study.
abstract: Iridium-192 is widely used for high-dose rate brachytherapy. Co-60 source with similar geometric and dosimetric properties are now available. It has a longer half life but higher energy than Iridium-192. If Co-60 source can produce similar results, it will be more economical for low resource settings.
  
  
  OBJECTIVE
  To evaluate the acute gastrointestinal and genitourinary toxicity associated with Co-60 source in the brachytherapy of cervical cancer.
  
  
  METHODS
  Seventy patients with cervical cancer received 45 Gy in 22 fractions of pelvic external beam radiotherapy and 19.5 Gy in 3 fractions of HDR with Co-60 source using tandem and ring applicators with 6 courses of cisplatin 50 mg/m(2) and 5 fluorouracil 1000 mg/m(2) every 3 weeks Toxicity was scored using NCI-CTC version 4.0.
  
  
  RESULTS
  The median total BED (Gy(10)) for tumor was 86.2 (84.4-88.8) while that for rectum (BED Gy(3)) was 124.4 (120-133). Two patients (3%) had grade 3 gastrointestinal toxicity while all others had ≤grade 2 toxicity and this is comparable with previous results.
  
  
  CONCLUSIONS
  Co-60 as HDR brachytherapy source is tolerable and is economical for low resource settings.
authors.affiliation: Department of Radiation Oncology, University College Hospital Ibadan, Nigeria.
authors.forename: Atara
authors.initials: A
authors.lastname: Ntekim
authors.forename: Adeniyi
authors.initials: A
authors.lastname: Adenipekun
authors.forename: Bidemi
authors.initials: B
authors.lastname: Akinlade
authors.forename: Oladapo
authors.initials: O
authors.lastname: Campbell