title: Community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction. Role of antibiotic combination of linezolid plus levofloxacin.
abstract: The therapeutic options available for central nervous system (CNS) infections due to resistant Gram-positive cocci remain limited. We report an unusual case of community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction in the middle cerebral artery territory in a previously healthy young male. After an initial vancomycin-based regimen, treatment was completed with a seven-week course of linezolid and levofloxacin. The potential role of such a combination and, particularly, linezolid as a first-line therapy in serious CNS infections is also discussed.
authors.affiliation: Department of Infectious Diseases, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Fernández-Ruiz
authors.forename: Carlos
authors.initials: C
authors.lastname: Cervera
authors.forename: Cristina
authors.initials: C
authors.lastname: Pitart
authors.forename: Gloria
authors.initials: G
authors.lastname: Pérez
authors.forename: Ana
authors.initials: A
authors.lastname: del Río
authors.forename: José M
authors.initials: JM
authors.lastname: Miró
authors.forename: Francesc
authors.initials: F
authors.lastname: Marco
authors.forename: Asunción
authors.initials: A
authors.lastname: Moreno
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D017714:Community-Acquired Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006801:Humans; D064704:Levofloxacin; D000069349:Linezolid; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D015242:Ofloxacin / Q000008:administration & dosage*; D023303:Oxazolidinones / Q000008:administration & dosage*; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D064704:Levofloxacin; D015242:Ofloxacin; D000069349:Linezolid