title: Association between angiotensin II type 1 receptor gene polymorphism and metabolic syndrome in a young female Iranian population.
abstract: OBJECTIVE
  The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascular disease. There are reported associations between an angiotensin II type I receptor gene polymorphism (AT(1)R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk. In the present study, we aimed to investigate whether the AT(1)R/A1166C polymorphism was associated with MetS among adolescent Iranian girls.
  
  
  METHODS
  A total of 350 adolescent girls aged 15-17 years from high schools and different educational zones of Mashhad city participated in this population-based, genetic association study. Of these individuals, 101 patients had MetS (defined by the NCEP-ATP III criteria); the remaining 249 age-matched girls were considered as the control group. All subjects were genotyped for the AT(1)R/A1166C polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
  
  
  RESULTS
  Frequencies of the AA, AC and CC genotypes were 164 (65.9%), 80 (32.1%) and 5 (2.0%) in the control group and 79 (78.2%), 20 (19.8%) and 2 (2.0%) in patients, which were not consistent with the Hardy-Weinberg equilibrium (p <0.05 and p <0.001, respectively). Frequency of the AT(1)R C allele was found to be significantly lower in patients compared with controls (p <0.05).
  
  
  CONCLUSIONS
  Our findings suggested that the 1166C allele of AT(1)R gene may be associated with a decreased risk of MetS in adolescent Iranian females.
authors.affiliation: Biotechnology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Iran.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Alavi-Shahri
authors.forename: Javad
authors.initials: J
authors.lastname: Behravan
authors.forename: Mitra
authors.initials: M
authors.lastname: Hassany
authors.forename: Farnoosh
authors.initials: F
authors.lastname: Tatari
authors.forename: Jamal
authors.initials: J
authors.lastname: Kasaian
authors.forename: Rashin
authors.initials: R
authors.lastname: Ganjali
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Somayeh
authors.initials: S
authors.lastname: Sabouri
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Oladi
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Mirhosseini
authors.forename: Mohammad T
authors.initials: MT
authors.lastname: Shakeri
authors.forename: Shideh
authors.initials: S
authors.lastname: Montaser-Kouhsari
authors.forename: Shahireh
authors.initials: S
authors.lastname: Omidvar Tehrani
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Sophie
authors.initials: S
authors.lastname: Visvikis-Siest
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
mesh_terms: D005260:Female; D006801:Humans; D007492:Iran; D024821:Metabolic Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic; D011945:Receptors, Angiotensin / Q000235:genetics*
chemical_list: D011945:Receptors, Angiotensin