Successful salvage therapy with inhaled zanamivir in a patient with peramivir-resistant pandemic influenza A (H1N1) 2009 virus.
We describe a patient with multiple myeloma who developed a pandemic influenza A (H1N1) 2009 virus infection during chemotherapy. The clinical condition of the patient worsened and viral shedding persisted despite 10 days of peramivir treatment; however viral shedding ceased and the patient recovered completely with inhaled zanamivir.
Park
Ki-Ho
KH
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Lee
Sang-Oh
SO
Choi
Sang-Ho
SH
Kim
Mi-Na
MN
Lee
Je-Hwan
JH
Yi
Hwajung
H
Kim
Mi-Seon
MS
Hong
Eun-Hye
EH
Kim
Yang Soo
YS
Woo
Jun Hee
JH
Kim
Sung-Han
SH
D000146:Acids, Carbocyclic; D000280:Administration, Inhalation; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003517:Cyclopentanes / Q000494:pharmacology; D024882:Drug Resistance, Viral; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome; D017201:Virus Shedding; D053243:Zanamivir / Q000008:administration & dosage*
D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D053243:Zanamivir; C414210:peramivir