title: Cutaneous epidermal growth factor receptor system following ultraviolet irradiation: exploring the role of molecular mechanisms.
abstract: OBJECTIVE
  The epidermal growth factor receptor (EGFR) pathway appears to be essential in many cutaneous disorders. It is well established that ultraviolet (UV) irradiation activates the EGFR in the animal and human skin; however, the molecular mechanisms involved in such activation remain unclear. Our aim is to review and analyse them.
  
  
  METHODS
  Computerized search and selection of original papers in the MEDLINE database (PubMed) from 1988 to 2009 were performed. Systematic analysis and breakdown of the information selected were carried out.
  
  
  RESULTS
  Full manuscripts were retrieved for 32 citations. It was proven that UV light acts directly and indirectly on EGFR (ErbB1/ErbB2) and on numerous intermediaries of extracellular and intracellular signalling. The most closely observed changes imply concentrations and/or molecular activity of the reactive oxygen species group, hydrogen peroxide, matrix metalloproteinases, p38MAPKinase, p21WAF1, p53, signal transducers and activators of transcription 3 and telomerase.
  
  
  CONCLUSIONS
  Our results help to clarify the working and importance of the UV-EGFR system in the human skin.
authors.affiliation: Research Unit, IMC-Investiláser, Sabadell, Barcelona, Spain.
authors.forename: P A
authors.initials: PA
authors.lastname: Martínez-Carpio
authors.forename: M A
authors.initials: MA
authors.lastname: Trelles
mesh_terms: D066246:ErbB Receptors / Q000528:radiation effects*; D006801:Humans; D015398:Signal Transduction / Q000528:radiation effects*; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D066246:ErbB Receptors