title: Interaction of cationic phosphorus dendrimers (CPD) with charged and neutral lipid membranes.
abstract: Despite the rapid development of modern pharmaceutics, delivery of drugs to sites of action is not always effective. The research on new targeting delivery systems of pharmacologically active molecules is of great importance. Surface properties such as surface charge of drug delivery particles frequently define their pharmacokinetic profile; hence the efficiency of drugs can be increased by application of nanoparticles having appropriate surface properties. The aim of the present work was to study the interactions of cationic phosphorus-containing dendrimers (CPD) with model lipid membranes with no charge or bearing surface charge. The interactions of two generations of phosphorus dendrimers on the thermotropic behavior of model lipid membranes composed of DMPC (uncharged) or DMPC/DPPG (negatively charged) were studied using differential scanning calorimetry (DSC). The results of this study showed that CPDs can alter the thermotropic behaviour of the bilayer by reducing the cooperativity of phospholipids and this effect strongly depends on membrane surface charge. The information resulting from this study may be applied to the rational design of new drug carriers combining liposomal and dendrimeric technology.
authors.affiliation: Department of General Biophysics, University of Lodz, Banacha st. 12/16, 90-237 Lodz, Poland. maksion@biol.uni.lodz.pl
authors.forename: Maksim
authors.initials: M
authors.lastname: Ionov
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gardikis
authors.forename: Dominika
authors.initials: D
authors.lastname: Wróbel
authors.forename: Sophia
authors.initials: S
authors.lastname: Hatziantoniou
authors.forename: Helena
authors.initials: H
authors.lastname: Mourelatou
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Majoral
authors.forename: Barbara
authors.initials: B
authors.lastname: Klajnert
authors.forename: Maria
authors.initials: M
authors.lastname: Bryszewska
authors.forename: Costas
authors.initials: C
authors.lastname: Demetzos
mesh_terms: D002152:Calorimetry, Differential Scanning; D002412:Cations; D050091:Dendrimers / Q000737:chemistry*; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D008567:Membranes, Artificial; D010715:Phosphatidylglycerols / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*
chemical_list: D002412:Cations; D050091:Dendrimers; D008567:Membranes, Artificial; D010715:Phosphatidylglycerols; D010758:Phosphorus; D004134:Dimyristoylphosphatidylcholine; C030345:1,2-dipalmitoylphosphatidylglycerol