A second family with dominantly inherited isolated cleft palate.
Although a number of families have been reported with apparently dominantly inherited cleft lip with or without cleft palate, there is only 1 previous report of dominantly inherited isolated cleft palate. We report a 4-generation family with dominantly inherited clefts of the soft and hard palates, affecting both sexes and showing male-to-male transmission. We believe this is only the second such family and discuss possible reasons for the rarity of such pedigrees.
Powis
Zöe
Z
Division of Molecular and Medical Genetics, Department of Pediatrics, University of Arizona, Tucson, Arizona 85724-5073, USA.
Erickson
Robert P
RP
D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D010641:Phenotype