title: Metabolic abnormalities in children with asthma.
abstract: BACKGROUND
  Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. Yet, the relationship between asthma, obesity, and abnormal lipid and glucose metabolism is not well understood, nor has it been adequately explored in children.
  
  
  OBJECTIVE
  To analyze the relationship between asthma diagnosis and body mass in children across the entire range of weight percentile categories, and to test the hypothesis that early derangement in lipid and glucose metabolism is independently associated with increased risk for asthma.
  
  
  METHODS
  Cross-sectional analysis of a representative sample of public school children from a statewide community-based screening program, including a total of 17,994 children, 4 to 12 years old, living in predominantly rural West Virginia, and enrolled in kindergarten, second, or fifth grade classrooms.
  
  
  RESULTS
  We analyzed demographics; family history; smoke exposure; parent-reported asthma diagnosis; body mass index; evidence of acanthosis nigricans as a marker for developing insulin resistance; and fasting serum lipid profile including total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Regardless of their body mass index percentile, children diagnosed with asthma were more likely than children without asthma to have higher triglyceride levels and acanthosis nigricans after controlling for sex differences and smoke exposure.
  
  
  CONCLUSIONS
  This study provides the first set of community-based data linking asthma, body mass, and metabolic variables in children. In particular, these findings uniquely describe a statistically significant association between asthma and abnormal lipid and glucose metabolism beyond body mass index associations.
authors.affiliation: Department of Pediatrics, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506-9214, USA. gpiedimonte@hsc.wvu.edu
authors.forename: Lesley
authors.initials: L
authors.lastname: Cottrell
authors.forename: William A
authors.initials: WA
authors.lastname: Neal
authors.forename: Christa
authors.initials: C
authors.lastname: Ice
authors.forename: Miriam K
authors.initials: MK
authors.lastname: Perez
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piedimonte
mesh_terms: D000052:Acanthosis Nigricans / Q000453:epidemiology; D017677:Age Distribution; D001249:Asthma / Q000097:blood / Q000453:epidemiology*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D012424:Rural Population / Q000706:statistics & numerical data; D014903:West Virginia / Q000453:epidemiology
chemical_list: D008055:Lipids