Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol.
We report two patients, a daughter and a mother, with lipoprotein glomerulopathy (LPG) who were successfully treated with niceritrol. Both patients carried a mutation in the apolipoprotein E (apoE) gene known as ApoE Tokyo/Maebashi. The daughter was found to have proteinuria at the age of 4 years. Four years later, she was diagnosed as having LPG based on a renal biopsy. She was treated with several medications including pravastatin, ethyl icosapentate, enalapril, warfarin and cyclophosphamide, all of which failed to reduce her proteinuria. At the age of 17 years, she exhibited an increase in proteinuria and a decline in renal function, despite ongoing treatment with pravastatin and enalapril. After switching from pravastatin to niceritrol, a marked reduction in the proteinuria and an improvement in renal function were observed. Her mother was found to have proteinuria at the age of 57 years and was diagnosed as having LPG based on a renal biopsy. She was also treated with niceritrol, resulting in an improvement in her proteinuria and renal function. These cases suggest that niceritrol might be a useful therapeutic option for LPG.
Hamatani
Hiroko
H
Dialysis and Rheumatology Center, Toho Hospital, 1155 Azami, Kasagake-machi, Midori, Gunma 379-2311, Japan. hamatani@gunma-u.ac.jp
Hiromura
Keiju
K
Kobatake
Keiko
K
Yoshida
Hiroaki
H
Kobayashi
Satsuki
S
Yoneda
Naohiro
N
Kayakabe
Ken
K
Matsumoto
Takayuki
T
Kuroiwa
Takashi
T
Ueki
Kazue
K
Nojima
Yoshihisa
Y
D000293:Adolescent; D001057:Apolipoproteins E / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008875:Middle Aged; D009154:Mutation; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000235:genetics; D009531:Niceritrol / Q000627:therapeutic use*; D010375:Pedigree; D011507:Proteinuria / Q000188:drug therapy* / Q000235:genetics
D001057:Apolipoproteins E; D009531:Niceritrol