Gene regulation: enhancers stepping out of the shadow.
The expression of many animal genes has been shown to be controlled by two--rather than one--enhancers with similar regulatory content. Such enhancer redundancy ensures robustness of gene expression under adverse environmental or genetic conditions.
Hobert
Oliver
O
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA. or38@columbia.edu
D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation