title: Prognostic factors in women treated for ovarian yolk sac tumour: a retrospective analysis of 84 cases.
abstract: BACKGROUND
  Ovarian yolk sac tumour (OYST) is a very rare malignancy arising in young women. Our study aimed to evaluate long-term outcomes and to identify prognostic parameters likely to help make appropriate risk-based decisions about therapy in this disease.
  
  
  METHODS
  This retrospective study is based on prospectively recorded OYST cases at the Institut Gustave-Roussy. A univariate analysis using the logrank test evaluated possible associations between survival and patient or disease covariates. The multivariate analysis was performed using the Cox proportional hazard regression method.
  
  
  RESULTS
  Between 1976 and 2006, 84 patients were registered. Since 1991, most of the patients have undergone fertility-sparing surgery. With a median follow-up of 71 months, the overall 5-year and event-free survival rates are 84% and 79%, respectively. In the multivariate model only the absence of ascites and a favourable serum AFP decline rate were significantly associated with better overall survival.
  
  
  CONCLUSIONS
  Patients with a poor prognosis factor such as an unfavourable serum AFP decline may be considered for aggressive treatment whereas those with good prognostic factors could be given less courses of chemotherapy.
authors.affiliation: Department of Medical Oncology, Institut Gustave-Roussy, Villejuif, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: de La Motte Rouge
authors.forename: Patricia
authors.initials: P
authors.lastname: Pautier
authors.forename: Annie
authors.initials: A
authors.lastname: Rey
authors.forename: Pierre
authors.initials: P
authors.lastname: Duvillard
authors.forename: Pierre
authors.initials: P
authors.lastname: Kerbrat
authors.forename: Frédéric
authors.initials: F
authors.lastname: Troalen
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine
authors.forename: Catherine
authors.initials: C
authors.lastname: Lhommé
mesh_terms: D018240:Endodermal Sinus Tumor / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control; D053208:Kaplan-Meier Estimate; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins