title: Is elevated SUA associated with a worse outcome in young Chinese patients with acute cerebral ischemic stroke?
abstract: BACKGROUND
  Elevated serum uric acid (SUA) levels can enhance its antioxidant prosperities and reduce the occurrence of cerebral infarction. Significantly elevated SUA levels have been associated with a better prognosis in patients with cerebral infarction; however, the results from some studies on the relationship between SUA and the prognosis of patients with cerebral infarction remain controversial.
  
  
  METHODS
  We analyzed the relationship between SUA and clinical prognosis of 585 young Chinese adults with acute ischemic stroke as determined by the modified Rankin Scale at discharge. Using multivariate logistic regression modeling, we explore the relationship between SUA levels and patient's clinical prognosis.
  
  
  RESULTS
  Lower SUA levels at time of admission were observed more frequently in the lowest quintile for patients with severe stroke (P = 0.02). Patients with cerebral infarction patients caused by small-vessel blockage had higher SUA concentrations (P = 0.01) and the lower mRS scores (P < 0.01) were observed in, while the lowest SUA concentrations and the highest mRS scores were seen in patients with cardiogenic cerebral infarction patients. Logistic regression analysis adjusted for confounders confirmed the following independent predictors for young cerebral infarction: uric acid (-0.003: 95%CI 0.994 to 0.999) and platelet (0.004, 95%CI 0.993 to 0.996).
  
  
  CONCLUSIONS
  Elevated SUA is an independent predictor for good clinical outcome of acute cerebral infarction among young adults.
authors.affiliation: Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang east Road, GuangZhou, 510260 Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Cong
authors.initials: C
authors.lastname: Gao
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.forename: WeiZhi
authors.initials: W
authors.lastname: Zhang
authors.forename: XingWang
authors.initials: X
authors.lastname: Song
authors.forename: JianRui
authors.initials: J
authors.lastname: Yin
authors.forename: ShuXiang
authors.initials: S
authors.lastname: Pu
authors.forename: YongHong
authors.initials: Y
authors.lastname: Yi
authors.forename: QingChun
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid