Role of neoadjuvant chemotherapy in congenital intracranial haemangiopericytoma.
Infantile haemangiopericytoma of the CNS is a rare entity. We report the first case of a congenital haemangiopericytoma successfully treated by preoperative chemotherapy. The patient presented shortly after birth with the diagnosis of a haemangiopericytoma. As neurosurgery was too risky due to size, location and age of the patient an anthracycline-based chemotherapeutic regimen was applied and resulted in a significant decrease in tumour size, making a postchemotherapy complete surgical resection possible. Chemotherapy may benefit patients with congenital haemangiopericytoma especially if the tumour cannot initially be treated by complete neurosurgical resection.
Kerl
Kornelius
K
Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.
Sträter
Ronald
R
Hasselblatt
Martin
M
Brentrup
Angela
A
Frühwald
Michael C
MC
D018943:Anthracyclines / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000151:congenital / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006393:Hemangiopericytoma / Q000151:congenital / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D020360:Neoadjuvant Therapy / Q000379:methods*; D011300:Preoperative Care
D018943:Anthracyclines