title: Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.
abstract: New series of 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones (8a-j) and 2,5-disubstituted-1,3,4-thiadiazoles (9a-h) were synthesized by dehydrative cyclization of hydrazinecarbothioamide derivatives (7a-k) by refluxing in 4N aqueous sodium hydroxide and by overnight stirring with polyphosphoric acid, respectively. The structures of the newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR, elemental analysis and mass spectroscopic studies and the synthesized compounds were screened for their antioxidant and urease inhibition activities. N-(2,4-Dimethylphenyl)-5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine (9h) showed excellent antioxidant activity more than the standard drug whereas 4-(2,4-dimethylphenyl)-5-(3-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (8d) and 4-(2,3-dimethylphenyl)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (8e) exhibited potent urease inhibitory activities.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Khan
authors.forename: Sajid
authors.initials: S
authors.lastname: Ali
authors.forename: Shahid
authors.initials: S
authors.lastname: Hameed
authors.forename: Nasim Hasan
authors.initials: NH
authors.lastname: Rama
authors.forename: Muhammad Tahir
authors.initials: MT
authors.lastname: Hussain
authors.forename: Abdul
authors.initials: A
authors.lastname: Wadood
authors.forename: Reaz
authors.initials: R
authors.lastname: Uddin
authors.forename: Zaheer
authors.initials: Z
authors.lastname: Ul-Haq
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ali
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D013830:Thiadiazoles; D014230:Triazoles; D014510:Urease