title: Hormonal and ultrasound markers of ovarian function in a woman with a balanced 1;11 translocation.
abstract: OBJECTIVE
  To present a case of a poor responder woman with a rare balanced autosomal translocation.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Infertility center in a university teaching hospital.
  
  
  METHODS
  A 34-year-old white woman with primary infertility.
  
  
  METHODS
  Laboratory and ultrasound evaluation, karyotype analysis, ovarian stimulation with gonadotropins.
  
  
  METHODS
  Markers of ovarian reserve and ovarian response to gonadotropin stimulation.
  
  
  RESULTS
  The patient was a carrier of a balanced translocation (1;11) (q23;p11.2). The hormone ovarian reserve markers (FSH, anti-Mullerian hormone, inhibin B) were within the normal range. The antral follicle count (AFC) was measured twice and only in one occasion did it reach the lower limit of the normal range. Furthermore, the patient had regular menstrual cycles. However, ovarian response to the administration of a maximal dose FSH was extremely poor.
  
  
  CONCLUSIONS
  Patients with balanced autosomal translocations should be counseled regarding their increased risk for poor response even if markers of ovarian reserve are in the range of normality.
authors.affiliation: Mother Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy. giovanni_dippolito@yahoo.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Ippolito
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tirelli
authors.forename: Simone
authors.initials: S
authors.lastname: Giulini
authors.forename: Annibale
authors.initials: A
authors.lastname: Volpe
authors.forename: Antonio
authors.initials: A
authors.lastname: La Marca
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D002452:Cell Count; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006728:Hormones / Q000032:analysis / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D010053:Ovary / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology*; D014178:Translocation, Genetic; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D006728:Hormones