Synthetic studies on the mycolactone core.
Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.
Ko
Kwang-Seuk
KS
Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
Alexander
Matthew D
MD
Fontaine
Shaun D
SD
Biggs-Houck
James E
JE
La Clair
James J
JJ
Burkart
Michael D
MD
D000475:Alkenes; D001427:Bacterial Toxins / Q000138:chemical synthesis* / Q000737:chemistry*; D018942:Macrolides; D009161:Mycobacterium / Q000737:chemistry
D000475:Alkenes; D001427:Bacterial Toxins; D018942:Macrolides; C117218:mycolactone