Asymmetric general base catalysis of the phospho-aldol reaction via dimeric aluminium hydroxides.
Dimeric aluminium hydroxide complexes containing the (R,R)-N,N'-bis(2'-hydroxy-3'-organobenzyl)-trans-1,2-diaminocyclohexane ligand backbone effect catalysis of the phospho-aldol reaction under ambient, aerobic conditions at catalyst loadings of 0.5 mol% to afford enantioselectivities of ca. 65%.
Gledhill
Alexandra C
AC
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK.
Cosgrove
Nichola E
NE
Nixon
Tracy D
TD
Kilner
Colin A
CA
Fisher
Julie
J
Kee
Terence P
TP