title: Lung transplantation for severe antineutrophilic cytoplasmic antibody-associated vasculitis.
abstract: Antineutrophil cytoplasmic antibody-associated vasculitis is a life-threatening disorder for which medical therapy has greatly improved survival. However, there is still significant mortality associated with antineutrophil cytoplasmic antibody-associated vasculitis. Little data exists on the utility of lung transplantation for patients, especially with an acute and severe form of this disease. Herein, we report successful lung transplantation for a patient with life-threatening pulmonary hemorrhage and respiratory failure as a consequence of this pulmonary renal syndrome.
authors.affiliation: Department of Medicine, Uníversity of Alberta, Edmonton, Canada. justin.weinkauf@ualberta.ca
authors.forename: J
authors.initials: J
authors.lastname: Weinkauf
authors.forename: L
authors.initials: L
authors.lastname: Puttagunta
authors.forename: K
authors.initials: K
authors.lastname: Stewart
authors.forename: A
authors.initials: A
authors.lastname: Humar
authors.forename: J
authors.initials: J
authors.lastname: Homik
authors.forename: S
authors.initials: S
authors.lastname: Caldwell
authors.forename: M
authors.initials: M
authors.lastname: Fenton
authors.forename: R
authors.initials: R
authors.lastname: Nador
authors.forename: Dale
authors.initials: D
authors.lastname: Lien
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000974:Antibodies, Antinuclear / Q000276:immunology*; D003520:Cyclophosphamide; D003593:Cytoplasm / Q000276:immunology; D005921:Glomerulonephritis / Q000209:etiology*; D006469:Hemoptysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D016040:Lung Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D010956:Plasmapheresis; D006435:Renal Dialysis / Q000379:methods; D016896:Treatment Outcome; D014657:Vasculitis / Q000276:immunology / Q000601:surgery*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D003520:Cyclophosphamide