title: Isoquinoline-based chiral monodentate N-heterocyclic carbenes.
abstract: C(1)-symmetric isoquinoline-based chiral diaminocarbene ligands (MIQ) have been developed to block three quadrants of the metal coordination sphere, complementing C(2)-symmetric biisoquinoline-based ligands (BIQ). MIQ-Cu complexes catalyzed conjugate borylation of various α,β-unsaturated amides in good yields (82-99%) and enantioselectivities (75-87% ee).
authors.affiliation: Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL 32611-7200, USA.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Hirsch-Weil
authors.forename: Khalil A
authors.initials: KA
authors.lastname: Abboud
authors.forename: Sukwon
authors.initials: S
authors.lastname: Hong
mesh_terms: D000577:Amides / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry*; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D006571:Heterocyclic Compounds; D007546:Isoquinolines; D008024:Ligands; C030011:carbene; C039109:isoquinoline; D008697:Methane