In vitro biocompatibility of plasma-aided surface-modified 316L stainless steel for intracoronary stents.
316L-type stainless steel is a raw material mostly used for manufacturing metallic coronary stents. The purpose of this study was to examine the chemical, wettability, cytotoxic and haemocompatibility properties of 316L stainless steel stents which were modified by plasma polymerization. Six different polymeric compounds, polyethylene glycol, 2-hydroxyethyl methacrylate, ethylenediamine, acrylic acid, hexamethyldisilane and hexamethyldisiloxane, were used in a radio frequency glow discharge plasma polymerization system. As a model antiproliferative drug, mitomycin-C was chosen for covalent coupling onto the stent surface. Modified SS 316L stents were characterized by water contact angle measurements (goniometer) and x-ray photoelectron spectroscopy. C1s binding energies showed a good correlation with the literature. Haemocompatibility tests of coated SS 316L stents showed significant latency (t-test, p < 0.05) with respect to SS 316L and control groups in each test.
Bayram
Cem
C
Nanotechnology and Nanomedicine Division, The Institute For Graduate Studies in Science and Engineering, Hacettepe University, 06800 Ankara, Turkey.
Mizrak
Alpay Koray
AK
Aktürk
Selçuk
S
Kurşaklioğlu
Hurkan
H
Iyisoy
Atila
A
Ifran
Ahmet
A
Denkbaş
Emir Baki
EB
D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D001769:Blood; D001780:Blood Coagulation Tests; D001826:Body Fluids / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D008689:Methacrylates / Q000737:chemistry; D016685:Mitomycin / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013193:Stainless Steel / Q000737:chemistry*; D015607:Stents; D013499:Surface Properties; D018675:Toxicity Tests; D017155:Wettability
D000903:Antibiotics, Antineoplastic; D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D011108:Polymers; D013193:Stainless Steel; D011092:Polyethylene Glycols; D016685:Mitomycin; C005044:hydroxyethyl methacrylate