title: Multicentric castleman disease in a child with primary immunodeficiency.
abstract: Multicentric Castleman disease is a rare lymphoproliferative disorder mostly seen in adults with HIV. It presents with fever and systemic symptoms and is extremely uncommon in children. We describe a novel case of multicentric Castleman disease associated with primary immunodeficiency (common variable immunodeficiency) and discuss pathophysiologic mechanisms and recent advances in understanding this disease.
authors.affiliation: Division of Allergy and Clinical Immunology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Drolet
authors.forename: Marie-Astrid
authors.initials: MA
authors.lastname: Lefebvre
authors.forename: Chantal
authors.initials: C
authors.lastname: Bernard
authors.forename: David
authors.initials: D
authors.lastname: Mitchell
authors.forename: Christine
authors.initials: C
authors.lastname: McCusker
authors.forename: Bruce
authors.initials: B
authors.lastname: Mazer
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005871:Castleman Disease / Q000188:drug therapy* / Q000209:etiology* / Q000821:virology; D002648:Child; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D011379:Prognosis
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone