title: A thiophen-thiooxorhodamine conjugate fluorescent probe for detecting mercury in aqueous media and living cells.
abstract: A rhodamine-based sensor RB-S2 was designed and synthesized by combination of the thiospirolacton chromophore and the thiophen ring block with high affinity to Hg(2+). Probe RB-S2 exhibits high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Hg(2+) in aqueous solution. In addition, fluorescent imaging of Hg(2+) in MCF-7 cells is also successfully demonstrated.
authors.affiliation: College of Science and State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: You
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.forename: Ju-Ying
authors.initials: JY
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008628:Mercury / Q000032:analysis*; D008856:Microscopy, Fluorescence / Q000379:methods; D012235:Rhodamines / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; D013876:Thiophenes; D008628:Mercury