Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus.
We evaluated the effect of aminoguanidine on pulmonary oxidative stress and lung structure in an experimental model of diabetes mellitus. Thiobarbituric acid reactive substances (TBARS), histology and arterial blood gases were evaluated in animals with diabetes mellitus (DM group), animals with diabetes mellitus treated with aminoguanidine (DM+AG group), and controls. The TBARS levels were significantly higher in the DM group than in the control and DM+AG groups (2.90 ± 1.12 vs. 1.62 ± 0.28 and 1.68 ± 0.04 nmol/mg protein, respectively), as was PaCO2 when compared with that of the control group (49.2 ± 1.65 vs. 38.12 ± 4.85 mmHg), and PaO2 was significantly higher in the control group (104.5 ± 6.3 vs. 16.30 ± 69.48 and 97.05 ± 14.02 mmHg, respectively). In this experimental model of diabetes mellitus, aminoguanidine reduced oxidative stress, structural tissue alterations, and gas exchange.
Di Naso
Fabio Cangeri
FC
Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Forgiarini Junior
Luiz Alberto
LA
Forgiarini
Luiz Felipe
LF
Porawski
Marilene
M
Dias
Alexandre Simões
AS
Marroni
Norma Anair Possa
NA
D000704:Analysis of Variance; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology*; D006146:Guanidines / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D006146:Guanidines; D017392:Thiobarbituric Acid Reactive Substances