In vivo biodistribution and efficacy of peptide mediated delivery.
To transverse the plasma membrane and gain access to the cellular interior is one of the major obstacles for many novel pharmaceutical molecules. Since the late 1990s, cell-penetrating peptides (CPPs) have been utilized as transport vectors for a broad spectrum of 'biological cargoes', ranging from inert gold particles to multifaceted macromolecules such as proteins and plasmids. Numerous studies have shown that CPPs are efficient carriers for bioactive cargoes in vitro. However, even though CPPs are versatile transport vectors, this does not guarantee they can be developed into useful pharmaceutical molecules. Nevertheless, recent progress in the field has shown CPPs to be effective for in vivo delivery with retained biological activity of a wide variety of bioactive cargoes into virtually any mammalian tissue. This review will focus on recent developments and applications for CPP delivery and distribution in vivo.
Järver
Peter
P
School of Biotechnology, Department of Molecular Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.
Mäger
Imre
I
Langel
Ülo
Ü
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000633:toxicity; D004337:Drug Carriers; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D009841:Oligonucleotides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism / Q000494:pharmacology; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D014018:Tissue Distribution
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D009841:Oligonucleotides; D011506:Proteins; D034741:RNA, Small Interfering