Occurrence, efficacy, metabolism, and toxicity of triclosan.
Triclosan has broad-spectrum anti-microbial activity against most gram-negative and gram-positive bacteria. It is widely used in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive life-time exposures to triclosan, and, indeed, triclosan has been detected in human tissues and the environment. Data gaps exist regarding the chronic dermal toxicity and carcinogenicity of triclosan, which is needed for the risk assessment of triclosan. The US Food and Drug Administration (FDA) nominated triclosan to the National Toxicology Program (NTP) for toxicological evaluations. Currently, the NTP is conducting several dermal toxicological studies to determine the carcinogenic potential of triclosan, evaluate its endocrine and developmental-reproductive effects, and investigate the potential UV-induced dermal formation of chlorinated phenols and dioxins of triclosan. This paper reviews data on the human exposure, environmental fate, efficacy of anti-microbial activity, absorption, distribution, metabolism and elimination, endocrine disrupting effects, and toxicity of triclosan.
Fang
Jia-Long
JL
National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. jia-long.fang@fda.hhs.gov
Stingley
Robin L
RL
Beland
Frederick A
FA
Harrouk
Wafa
W
Lumpkins
Debbie L
DL
Howard
Paul
P
D000890:Anti-Infective Agents / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D014260:Triclosan / Q000378:metabolism / Q000633:toxicity
D000890:Anti-Infective Agents; D014260:Triclosan