title: Intraoperative blood loss predicts hemorrhage-related reoperation after orthotopic liver transplantation.
abstract: Postoperative hemorrhage after orthotopic liver transplantation (OLT) may require early reoperative intervention. Previous studies have shown intraoperative transfusion requirement as a main determinant of reoperative intervention after OLT. The goal of this study was to develop an intraoperative hemorrhage model predicting need for reoperation after OLT. A single institution, retrospective review of adult primary OLT patients from January 2002 to 2008 was conducted. Multivariate logistical regression analysis was performed to identify predictors of reoperation due to postoperative hemorrhage. Secondary analysis was conducted on patients in the reoperation group managed with temporary open abdomen techniques. Four hundred and ten primary transplantations were performed with 59 patients (14.4%) requiring reoperation. The adjusted odds of reoperation when intraoperative blood loss (IBL) increases from 1.5 L to 10.0 L is 2.48 [95% confidence interval: (1.18, 5.31)]. IBL of 10.0 L predicts a 19.4 per cent probability of reoperation. Patients managed with open abdomen (n = 8) exhibited a significant IBL difference (16.0 L vs. 6.0 L, P < 0.001) when compared with the closed abdomen cohort. Our results indicate that intraoperative blood loss is the primary predictor of reoperation after OLT and provide a hemorrhage threshold to guide postoperative management of complicated OLT patients.
authors.affiliation: Vanderbilt School of Medicine, Department of Surgery, Nashville, Tennessee, USA.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Kappa
authors.forename: D Lee
authors.initials: DL
authors.lastname: Gorden
authors.forename: Mario A
authors.initials: MA
authors.lastname: Davidson
authors.forename: J Kelly
authors.initials: JK
authors.lastname: Wright
authors.forename: Oscar D
authors.initials: OD
authors.lastname: Guillamondegui
mesh_terms: D016063:Blood Loss, Surgical; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000453:epidemiology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D019106:Postoperative Hemorrhage / Q000453:epidemiology*; D011379:Prognosis; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014184:Transplantation, Homologous