Anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytum borivilianum.
In the present investigation anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytum borivilianum were evaluated. Chlorophytum borivilianum root extract had no toxic effect up to a dose of 800 mg/kg body weight/day. Significant increase (p<0.05 to p<0.001) in the activity of reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) and a significant decrease in the hepatic MDA level were observed at 100, 400, and 800 mg/kg body weight of Chlorophytum borivilianum root extract when compared with the control value. Skin papillomagenesis studies demonstrated a significant (p<0.001) decrease in cumulative numbers of papilloma, tumour incidence, tumour burden, tumour size and tumour weight and significant (p<0.01) increase in average latent period when the animals received Chlorophytum borivilianum root extract at a dose level of 800 mg/kg body weight/day orally in double distilled water at pre, peri and post initiation stages of carcinogenesis. A significant reduction in the frequency of chromosomal aberration and micronuclei was observed in the treated animals as compared to carcinogen controls. The present investigation suggests that Chlorophytum borivilianum has anti-tumour, anti-mutagenic and chemomodulatory effects.
Kumar
Manish
M
Radiation and Cancer Biology Laboratory, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
Meena
Priyadarshi
P
Verma
Shekhar
S
Kumar
Madhu
M
Kumar
Ashok
A
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D016587:Antimutagenic Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D019668:Liliaceae / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013482:Superoxide Dismutase / Q000378:metabolism
D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D002273:Carcinogens; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione