The association between blood glucose and oxidized lipoprotein(a) in healthy young women.
BACKGROUND
Oxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein. Increased blood glucose concentrations can induce oxidative modification of lipoproteins. The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose.


METHODS
Several cardiometabolic variables and serum oxLp(a) (using an ELISA system) were measured among 70 healthy females (mean age, 22 years).


RESULTS
Lp(a) and glucose were significantly and positively correlated with oxLp(a) in simple correlation test. Furthermore, a multiple linear regression analysis showed oxLp(a) to have a weakly, but significantly positive and independent correlation with only blood glucose (β = 0.269, P < 0.05).


CONCLUSIONS
These results suggest that increased glucose may enhance the oxidization of Lp(a) even at normal glucose levels.
Kotani
Kazuhiko
K
Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp
Yamada
Shingo
S
Uurtuya
Shuumarjav
S
Yamada
Toshiyuki
T
Taniguchi
Nobuyuki
N
Sakurabayashi
Ikunosuke
I
D000293:Adolescent; D000328:Adult; D053241:Apoprotein(a) / Q000097:blood / Q000737:chemistry; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology*; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood* / Q000737:chemistry*; D008074:Lipoproteins / Q000097:blood; D010084:Oxidation-Reduction; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D055815:Young Adult
D001786:Blood Glucose; D008055:Lipids; D017270:Lipoprotein(a); D008074:Lipoproteins; D053241:Apoprotein(a)