Modulating the development of E. coli biofilms with 2-aminoimidazoles.
The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported. Each member of the library was screened for its ability to inhibit or promote biofilm development of either Escherichia coli and Acinetobacter baumannii. From this screen, E. coli-selective 2-aminoimidazoles were discovered, with the best inhibitor inhibiting biofilm development with an IC(50) of 13μM. The most potent promoter of E. coli biofilm formation promoted biofilm development by 321% at 400μM.
Reed
Catherine S
CS
Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States.
Huigens
Robert W
RW
Rogers
Steven A
SA
Melander
Christian
C
D040981:Acinetobacter baumannii / Q000187:drug effects / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007093:Imidazoles