CST meets shelterin to keep telomeres in check.
Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
Giraud-Panis
Marie-Josèphe
MJ
Laboratory of Biology and Pathology of Genomes, University of Nice, CNRS UMR 6267, U998 INSERM, 28 Avenue Valombrose Faculté de Médecine, 06107 Nice, Cedex 2, France.
Teixeira
M Teresa
MT
Géli
Vincent
V
Gilson
Eric
E
D019926:Cyclin B / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication / Q000502:physiology*; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism*; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism; D004718:Saccharomycetales / Q000235:genetics / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism*; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000235:genetics / Q000378:metabolism*
C498823:Cdc13 protein, S pombe; D019926:Cyclin B; D004271:DNA, Fungal; D046912:Multiprotein Complexes; D029702:Schizosaccharomyces pombe Proteins; C523517:Stn1 protein, S pombe; D034501:Telomere-Binding Proteins; C523518:Ten1 protein, S pombe; D019098:Telomerase