title: Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark.
abstract: OBJECTIVE
  Clinical manifestations and metabolic risk factors may differ in ethnic subgroups of patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective trans-sectional study.
  
  
  METHODS
  One thousand and two premenopausal women with the diagnoses hirsutism or PCOS were divided according to ethnicity: Caucasian (CA, n = 784), Middle East (ME, n = 190), Asian (n = 14) and others (n = 14).
  
  
  METHODS
  Clinical evaluation (hirsutism, BMI, waist, blood pressure), hormone analyses (testosterone, sex hormone-binding globulin, prolactin, lipids, insulin, glucose) and transvaginal ultrasound were performed. Oral glucose tolerance tests (OGTT) (n = 499) and ACTH tests (n = 434) were performed in a subgroup of patients.
  
  
  RESULTS
  (CA vs ME women) CA women were older [32(25-37) vs 25(18-32) years, median (quartiles)] and had increased BMI compared to ME women. After correcting for age and BMI, CA women were less hirsute, but had increased testosterone levels compared to ME women. The Rotterdam criteria were fulfilled in 56% of both populations, but PCO was diagnosed in 47% CA vs 29% ME women, P < 0·01. CA women had increased blood pressure and smoked at a higher frequency (40 vs 23%), whereas area under the curve for insulin during OGTT was decreased, all P < 0·001. Prolactin levels were significantly lower in CA women compared to ME women [7(5-10) vs 9(6-12) μg/l] and were inversely associated with smoking status.
  
  
  CONCLUSIONS
  CA women had a more adverse cardiovascular profile than ME women, whereas insulin sensitivity was higher. The prevalence of the individual Rotterdam criteria differed significantly in the two study populations.
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark. d.glintborg@gmail.com
authors.forename: Dorte
authors.initials: D
authors.lastname: Glintborg
authors.forename: Hanne
authors.initials: H
authors.lastname: Mumm
authors.forename: David
authors.initials: D
authors.lastname: Hougaard
authors.forename: Pernille
authors.initials: P
authors.lastname: Ravn
authors.forename: Marianne
authors.initials: M
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000208:ethnology* / Q000378:metabolism; D017697:Premenopause / Q000097:blood; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D044465:White People; D055815:Young Adult
chemical_list: D002096:C-Peptide; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone