title: [The study of the sensitive and specificity on HBV DNA replication by HBV-lP detecting].
abstract: OBJECTIVE
  To detect HBV-LP and HBV DNA of the patients with hepatitis B, and to study the sensitive and specificity of HBV-LP detecting and its evaluate on for clinical application.
  
  
  METHODS
  The ELISA was used for HBV-LP detecting and RT-PCR for HBV DNA detecting.
  
  
  RESULTS
  The sensitive and specificity of HBV-LP and HBV DNA were 64.89%, 99.68%, 60.63% and 100% respectively (P > 0.05); +LR, -LR were 202.78, 60.63, 0.3522 and 0.3937, and there were significance between +LR of the detecting (P < 0.005).
  
  
  CONCLUSIONS
  The sensitive and specificity of HBV-LP and HBV DNA detecting are considerable, +LR of HBV-LP are higher comparing HBV DNA. The HBV-LP is better serology index for detecting replication of HBV DNA.
authors.affiliation: The Laboratory Center of the Center Hospital of Shaoxing County, Zhejiang Shaoxing 312030, China.
authors.forename: Ping-Nan
authors.initials: PN
authors.lastname: Shan
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Lu
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Xuan
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Weng
authors.forename: Jin-Cheng
authors.initials: JC
authors.lastname: Ru
authors.forename: Su-Hong
authors.initials: SH
authors.lastname: Tan
authors.forename: De-Shun
authors.initials: DS
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D004261:DNA Replication; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*; D012680:Sensitivity and Specificity; D014759:Viral Envelope Proteins / Q000097:blood*; D055815:Young Adult
chemical_list: C096362:L protein, hepatitis B virus; D014759:Viral Envelope Proteins