Febrile cholestatic disease as an initial presentation of nodular lymphocyte-predominant Hodgkin lymphoma.
Febrile cholestatic liver disease is an extremely unusual presentation of Hodgkin lymphoma (HL). The liver biopsy of a 40-year-old man with febrile episodes and cholestatic laboratory pattern disclosed an uncommon subtype of HL, a nodular lymphocyte-predominant HL (NLPHL). Liver involvement in the early stage of the usually indolent NLPHL's clinical course suggests an aggressiveness and unfavorable outcome. Emphasizing a liver biopsy early in the diagnostic algorithm enables accurate diagnosis and appropriate treatment. Although rare, HL should be considered in the differential diagnosis of cholestasis.
Mrzljak
Anna
A
University of Zagreb, School of Medicine, Salata 3, 10000 Zagreb, Croatia. anna.mrzljak@gmail.com
Gasparov
Slavko
S
Kardum-Skelin
Ika
I
Colic-Cvrlje
Vesna
V
Ostojic-Kolonic
Slobodanka
S
D000328:Adult; D002779:Cholestasis / Q000209:etiology / Q000503:physiopathology; D017809:Fatal Outcome; D005334:Fever / Q000209:etiology / Q000503:physiopathology; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male