title: Type I interferon: friend or foe?
abstract: Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.
authors.affiliation: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. trinchig@mail.nih.gov
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trinchieri
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D012769:Shock / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
chemical_list: D007370:Interferon Type I; D007371:Interferon-gamma