Liver disease in the HIV-infected individual.
Since the advent of effective antiretroviral therapy (ART) for human immunodeficiency virus-1 (HIV), there has been a substantial decrease in deaths related to acquired immunodeficiency syndrome (AIDS). However, in the ART era, liver disease is now the most common non-AIDS-related cause of death among HIV-infected patients, accounting for 14%-18% of all deaths in this population and almost half of deaths among hospitalized HIV-infected patients. Just as the burden of non-AIDS morbidity and mortality has changed in the ART era, the types of liver disease the clinician is likely to encounter among these patients have changed as well. This review will discuss the causes of liver disease in the HIV-infected population in the ART era, including chronic hepatitis C virus, chronic hepatitis B virus, medication-related hepatotoxicity, alcohol abuse, nonalcoholic fatty liver disease, and AIDS-related liver diseases.
Price
Jennifer C
JC
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA. jcohen@jhmi.edu
Thio
Chloe L
CL
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000401:mortality; D005234:Fatty Liver / Q000453:epidemiology / Q000401:mortality; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000401:mortality; D019698:Hepatitis C, Chronic / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D008107:Liver Diseases / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D008108:Liver Diseases, Alcoholic / Q000453:epidemiology / Q000401:mortality; D065626:Non-alcoholic Fatty Liver Disease
D019380:Anti-HIV Agents