[Effects of Valeriana amurensis on the expressions of iNOS, COX-2 and IkappaCB-alpha in Alzheimer's disease model rat's brain].
OBJECTIVE
To investigate effects of Valeriana amurensis Smir. ex Kom. on the inflammation reaction of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain.


METHODS
The model of Alzheimer's disease was established with multiple factors and the expressions of iNOS, COX-2, IkappaB-alpha of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rats' brain were observed by electron lens using immunohistochemistry method.


RESULTS
The extracts of Valeriana amurensis could reduce the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin in a dose-dependent manner. The effects of 50% ethanol extracts of macroporous resin group were more significant than other groups.


CONCLUSIONS
The 50% ethanol extract of macroporous resin group from Valeriana amurensis can improve the ability of spatial exploratory and effectively control the inflammation reaction, the mechanism maybe relevant to it's effect of decreasing the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin to inhibit the activity of glia cell and inflammatory injury of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain.
Zhang
Zhong-Li
ZL
Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Zuo
Yue-Ming
YM
Wang
Qiu-Hong
QH
Xiao
Hong-Bin
HB
Kuang
Hai-Xue
HX
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D020672:I-kappa B Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D010446:Peptide Fragments; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014632:Valerian / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D020672:I-kappa B Proteins; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat