title: Modeling intersubject variability of bronchial doses for inhaled radon progeny.
abstract: The main sources of intersubject variations considered in the present study were: (1) size and structure of nasal and oral passages, affecting extrathoracic deposition and, in further consequence, the fraction of the inhaled activity reaching the bronchial region; (2) size and asymmetric branching of the human bronchial airway system, leading to variations of diameters, lengths, branching angles, etc.; (3) respiratory parameters, such as tidal volume, and breathing frequency; (4) mucociliary clearance rates; and (5) thickness of the bronchial epithelium and depth of target cells, related to airway diameters. For the calculation of deposition fractions, retained surface activities, and bronchial doses, parameter values were randomly selected from their corresponding probability density functions, derived from experimental data, by applying Monte Carlo methods. Bronchial doses, expressed in mGy WLM-1, were computed for specific mining conditions, i.e., for defined size distributions, unattached fractions, and physical activities. Resulting bronchial dose distributions could be approximated by lognormal distributions. Geometric standard deviations illustrating intersubject variations ranged from about 2 in the trachea to about 7 in peripheral bronchiolar airways. The major sources of the intersubject variability of bronchial doses for inhaled radon progeny are the asymmetry and variability of the linear airway dimensions, the filtering efficiency of the nasal passages, and the thickness of the bronchial epithelium, while fluctuations of the respiratory parameters and mucociliary clearance rates seem to compensate each other.
authors.affiliation: Division of Physics and Biophysics, Department of Materials Research and Physics, University of Salzburg, 5020 Salzburg, Austria. Werner.Hofmann@sbg.ac.at
authors.forename: Werner
authors.initials: W
authors.lastname: Hofmann
authors.forename: Renate
authors.initials: R
authors.lastname: Winkler-Heil
authors.forename: Majid
authors.initials: M
authors.lastname: Hussain
mesh_terms: D000465:Algorithms; D001980:Bronchi / Q000378:metabolism*; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008954:Models, Biological; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011874:Radiometry; D017687:Radon Daughters / Q000032:analysis / Q000378:metabolism* / Q000493:pharmacokinetics; D013269:Stochastic Processes
chemical_list: D017687:Radon Daughters