title: Multipotent adipose stromal cells and breast cancer development: Think globally, act locally.
abstract: It has long been appreciated that stromal cells within the breast tumor microenvironment contribute to mammary carcinogenesis. However, to date, very little is known regarding the role of local adipose-derived stromal cells (ASCs) in the development of breast cancer. Based on pathological, epidemiological and experimental data, we postulate that breast-derived ASCs are unique mesenchymal stem-like cells that play a critical role in the development of breast cancer and discuss the global implications of this working model in terms of breast cancer prevention, early detection, and new targeted therapies.
authors.affiliation: Department of Pathology, Virginia Commonwealth University, Richmond, 23298, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Cathy I
authors.initials: CI
authors.lastname: Dumur
authors.forename: Shawn E
authors.initials: SE
authors.lastname: Holt
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Beckman
authors.forename: Lynne W
authors.initials: LW
authors.lastname: Elmore
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D039902:Multipotent Stem Cells / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology*