title: A 12-month prospective, observational study of treatment regimen and quality of life associated with ADHD in central and eastern europe and eastern Asia.
abstract: OBJECTIVE
  This prospective, observational, non-randomized study aimed to describe the relationship between treatment regimen prescribed and the quality of life (QoL) of ADHD patients in countries of Central and Eastern Europe (CEE) and Eastern Asia over 12 months.
  
  
  METHODS
  977 Male and female patients aged 6-17 years seeking treatment for symptoms of ADHD were assessed using the Child and Adolescent Symptom Inventory-4 Parent Checklists, and the Clinical Global Impressions-ADHD-Severity scale. QoL was assessed using the Child Health and Illness Profile-Child Edition parent report form. Patients were grouped according to whether they were prescribed psycho- and/or pharmacotherapy (treatment) or not (no/'other' treatment).
  
  
  RESULTS
  No statistically significant differences were observed between cohorts (treatment vs. no/'other' treatment) in terms of change in QoL, although there was improvement over 12 months, with a greater improvement experienced by patients in the treatment cohort in both study regions (CEE and Eastern Asia). Psychoeducation/counselling and methylphenidate were the predominant ADHD treatments prescribed.
  
  
  CONCLUSIONS
  Although both treatment and no/'other' treatment cohorts showed improvements in mean QoL over 12 months, the difference was small and not statistically significant. A major limitation was the higher than anticipated number of patients switching treatments, predominantly from the no/'other' treatment cohort.
authors.affiliation: Charles University, Second Medical Faculty, Prague, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Goetz
authors.forename: Chin-Bin
authors.initials: CB
authors.lastname: Yeh
authors.forename: Igor
authors.initials: I
authors.lastname: Ondrejka
authors.forename: Aynur
authors.initials: A
authors.lastname: Akay
authors.forename: Ilona
authors.initials: I
authors.lastname: Herczeg
authors.forename: Iuliana
authors.initials: I
authors.lastname: Dobrescu
authors.forename: Boong Nyun
authors.initials: BN
authors.lastname: Kim
authors.forename: Xingming
authors.initials: X
authors.lastname: Jin
authors.forename: Anne W
authors.initials: AW
authors.lastname: Riley
authors.forename: Ferenc
authors.initials: F
authors.lastname: Martényi
authors.forename: Gavan
authors.initials: G
authors.lastname: Harrison
authors.forename: Tamás
authors.initials: T
authors.lastname: Treuer
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D003376:Counseling; D005061:Europe, Eastern; D005202:Asia, Eastern; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate