Design principles of the bacterial quorum sensing gene networks.
Bacterial quorum sensing (QS) has attracted much interest as the manifestation of collective behavior in prokaryotic organisms once considered strictly solitary. Significant amount of genetic, biochemical, and structural data which, has been accumulated in studies on QS in many species allows us to map properties of specific molecules and their interactions on the observed population-wide bacterial behavior. The present review attempts to give a systems biology perspective on the structure of genetic regulatory networks that control QS and considers functional implications of a variety of design principles that recur in the organization of these networks across species.
Goryachev
Andrew B
AB
Centre for Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
D018407:Bacterial Physiological Phenomena; D053263:Gene Regulatory Networks; D053038:Quorum Sensing; D049490:Systems Biology