Ovulation induction in polycystic ovary syndrome: No. 242, May 2010.
OBJECTIVE
To review current non-pharmacologic and pharmacologic options for ovulation induction in women with polycystic ovary syndrome (PCOS).


METHODS
This guideline reviews the evidence for the various options for ovulation induction in PCOS.


RESULTS
Ovulation, pregnancy and live birth rates, risks, and side effects are the outcomes of interest.


METHODS
Published literature was retrieved through searches of Medline using appropriate controlled vocabulary and key words. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Grey (unpublished) literature was identified through searching the websites of health technology assessment and of health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.


METHODS
The evidence gathered was reviewed and evaluated by the Reproductive Endocrinology and Infertility Committee of the Society of Obstetricians and Gynaecologists of Canada. The quality of evidence was quantified using the Canadian Task Force on Preventive Health Care.


RESULTS
Benefits include weight reduction and improvements in ovulation, pregnancy, and live birth rates. Potential harms include medication side effects and multiple pregnancies.


RESULTS
These guidelines have been reviewed and approved by the Reproductive Endocrinology and Infertility Committee of the SOGC.
Vause
Tannys D R
TD
Cheung
Anthony P
AP
Sierra
Sony
S
Claman
Paul
P
Graham
James
J
Guillemin
Jo-Anne
JA
Lapensée
Louise
L
Steward
Sabrina
S
Wong
Benjamin Chee-Man
BC
D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy* / Q000601:surgery; D008687:Metformin / Q000627:therapeutic use*; D010053:Ovary / Q000601:surgery; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D015431:Weight Loss
D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D006062:Gonadotropins; D007004:Hypoglycemic Agents; D002996:Clomiphene; D008687:Metformin