Meningoencephalitis caused by varicella-zoster virus reactivation in a child with dominant partial interferon-gamma receptor-1 deficiency.
We describe a previously symptom-free 13-year-old boy with dominant partial interferon-γ receptor-1 deficiency and unusual varicella-zoster virus reactivation. This case supports the unsettled notion that some interferon-γ R-deficient patients are at enhanced risk for viral disease.
Roesler
Joachim
J
Department of Pediatrics, University Hospital Carl Gustav Carus, Dresden, Germany. Joachim.Roesler@uniklinikum-dresden.de
Hedrich
Christian
C
Laass
Martin W
MW
Heyne
Klaus
K
Rösen-Wolff
Angela
A
D000293:Adolescent; D020804:Encephalitis, Varicella Zoster / Q000175:diagnosis* / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000821:virology*; D017471:Receptors, Interferon / Q000172:deficiency*; D014775:Virus Activation; D000096743:Interferon gamma Receptor
D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor