title: Reduced risk of prostate cancer in U.S. Men with AIDS.
abstract: BACKGROUND
  Previous studies describe decreased prostate cancer risk in HIV-infected men. In the United States, prostate-specific antigen (PSA) screening is common and increases the detection of prostate cancer. We evaluated whether the prostate cancer deficit among men with AIDS reflects differential PSA screening.
  
  
  METHODS
  Data from the U.S. HIV/AIDS Cancer Match Study were used to calculate standardized incidence ratios (SIR) for prostate cancer, comparing men with AIDS (N = 287,247) to the general population. Furthermore, we estimated PSA testing rates in the Johns Hopkins HIV Clinical Cohort.
  
  
  RESULTS
  Prostate cancer rates increased over time in the general population and, beginning in the 1990s, were consistently higher than among men with AIDS. Men with AIDS had the same prostate cancer risk as the general population in the pre-PSA era (<1992, SIR = 1.00), but significantly reduced risk during the PSA era overall (1992-2007, SIR = 0.50) and across age, race, HIV risk group, antiretroviral therapy era, and CD4 counts. Local and regional stage prostate cancer risk was lower among men with AIDS (SIRs, 0.49 and 0.14, respectively), but distant stage cancer risk did not differ (SIR = 0.85). Among HIV-infected men ≥40 years old, PSA testing was uncommon (18.7% per year), but increased 2.4-fold from 2000 to 2008, after age adjustment.
  
  
  CONCLUSIONS
  Prostate cancer risk was decreased by 50% among men with AIDS compared with the general population. This deficit was limited to the PSA era and early stage cancers.
  
  
  CONCLUSIONS
  Our findings suggest that the prostate cancer deficit in HIV-infected men is largely due to differential PSA screening.
authors.affiliation: Infections and Immunoepidemiology Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA. shielsms@mail.nih.gov
authors.forename: Meredith S
authors.initials: MS
authors.lastname: Shiels
authors.forename: James J
authors.initials: JJ
authors.lastname: Goedert
authors.forename: Richard D
authors.initials: RD
authors.lastname: Moore
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Platz
authors.forename: Eric A
authors.initials: EA
authors.lastname: Engels
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D055088:Early Detection of Cancer / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000821:virology*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D017430:Prostate-Specific Antigen