Diffuse plexiform neurofibroma of the back: report of a case.
Neurofibromatosis type 1 is an autosomal dominant disorder affecting the ras proto-oncogene. It is characterized by the overgrowth of nervous tissue and skin discoloration. While it is associated with a variety of phenotypic presentations, it is the plexiform variant that is particular concerning, as it can become extremely disfiguring and has a propensity for malignant degeneration. A case of a Pacific Islander with a large plexiform type 1 neurofibroma is presented. The patient was ultimately treated with surgical resection, negative pressure wound therapy, and split-thickness skin grafting with good results. A review of the literature concerning the diagnosis and treatment of neurofibromatosis is included.
Washington
Ezella N
EN
Tripler Army Medical Center, Honolulu, HI 96859, USA.
Placket
Timothy P
TP
Gagliano
Ronald A
RA
Kavolius
Jeffery
J
Person
Donald A
DA
D000328:Adult; D006801:Humans; D008297:Male; D054843:Negative-Pressure Wound Therapy; D018318:Neurofibroma, Plexiform / Q000473:pathology* / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000601:surgery*; D000090063:Proto-Oncogene Mas; D016038:Skin Transplantation; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000601:surgery