title: Two new eudesmanolides from Inula racemosa.
abstract: Two new eudesmane-type sesquiterpene lactones were isolated from the roots of Inula racemosa and their structures were elucidated as 3β-hydroxy-11α,13-dihydroalantolactone (1) and 11α-hydroxy-eudesm-5-en-8β,12-olide (2). Their cytotoxic activities against five human cancer cell lines had been tested and compound 2 exhibited weak cytotoxic activity against BEL-7402 and HCT-8 cell lines. The anti-inflammatory activities were also tested, but neither of them showed any activities.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Ting
authors.initials: T
authors.lastname: Gong
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044602:Cellulases / Q000037:antagonists & inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D018609:Tibet
chemical_list: C552789:11-hydroxy-eudesm-5-en-8beta,12-olide; C552788:3beta-hydroxy-11,13-dihydroalantolactone; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D045787:Sesquiterpenes, Eudesmane; D044602:Cellulases