title: Synthesis of axially chiral amino acid and amino alcohols via additive-ligand-free Pd-catalyzed domino coupling reaction and subsequent transformations of the product amidoaza[5]helicene.
abstract: Novel optically active axially chiral amino acid and amino alcohols have been synthesized efficiently via lactam ring-opening, with the aid of an optically active alcohol, amidoaza[5]helicene 5, which has been readily prepared by an additive-ligand-free Pd catalyzed domino coupling reaction in a single step. The stereostructures of these chiral molecules have also been clarified.
authors.affiliation: Institute for Chemical Research, Kyoto University, Uji 611-0011, Kyoto, Japan. furuta@fos.kuicr.kyoto-u.ac.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Furuta
authors.forename: Junya
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Ayano
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Hyuma
authors.initials: H
authors.lastname: Masu
authors.forename: Isao
authors.initials: I
authors.lastname: Azumaya
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
authors.forename: Takeo
authors.initials: T
authors.lastname: Kawabata
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000596:Amino Acids; D000605:Amino Alcohols; D008024:Ligands; D009942:Organometallic Compounds; D010165:Palladium