Sodium alginate as viscosity modifier may induce aggregation of red blood cells.
Viscosity of blood substitutes is among the important determinants to restore microcirculation. Sodium alginate (SA) is always mentioned as "viscosity modifier" in creating blood substitutes. In the present study, the whole blood was diluted using SA solutions to final hematocrits of 10%, 20%, and 35%, respectively. The whole blood viscosity (WBV) at different shear rates, plasma viscosity (PV), and rheological behavior of red blood cells (RBCs) was studied in vitro. The results show that SA may induce RBCs aggregation in a dose-dependent manner. Furthermore, the effect of SA on RBCs aggregation maybe involve the regulation of microcirculation.
Zhao
Lian
L
Department of Immunohematology, Beijing Institute of Transfusion Medicine, Beijing, China.
You
Guoxing
G
Liao
Fulong
F
Kan
Xuemei
X
Wang
Bo
B
Sun
Quanmei
Q
Xu
Huibin
H
Han
Dong
D
Zhou
Hong
H
D000328:Adult; D000464:Alginates / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D020723:Glucuronic Acid / Q000494:pharmacology; D006400:Hematocrit; D006603:Hexuronic Acids / Q000494:pharmacology; D006801:Humans; D013535:Suspensions
D000464:Alginates; D006603:Hexuronic Acids; D013535:Suspensions; D020723:Glucuronic Acid