No altered blood pressure and serum markers of oxidative stress after a long time dietary fish oil in the genetically 9 month-old type-2 diabetes Zucker rat.
In this study, we investigated the effect of a high n-3 fatty acid diet (eicosapentaenoic and docosahexaenoic acids) in Zucker obese and lean rats on blood pressure in association with physiological parameters, serum biochemistry and oxidative stress analysis. After 150 days of treatment, dietary fish oil supplementation in Zucker obese rats (9 months of age) reduces bodyweight gain and serum triglyceridemia and nitrite levels, increases serum glucose and angiotensin converting enzyme activity, but does not alter blood pressure, cholesterol levels and serum markers of oxidative stress (malondialdehyde, glutathione), compared to the Zucker rats fed control diet. According to these results, we can consider that after 150 days of treatment, fish oil is not enough to regulate parameters involved in the metabolic syndrome, such as cholesterolemia and blood pressure, in a 9 month-old genetically type-2 diabetes rat.
Tricot
Sompadthana
S
EA 2160 Mer Molécules Santé, PRES UNAM, Université du Maine, IUT de Laval, Département Génie Biologique, 52 rue des Drs Calmette et Guérin, BP 2045, 53020 Laval Cedex 9, France.
Mimouni
Virginie
V
Rompion
Sonia
S
Froger
Christelle
C
Lacroix
Pierre
P
Roux
Sylvain
S
Ulmann
Lionel
L
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics / Q000503:physiopathology*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D011924:Rats, Zucker
D015415:Biomarkers; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D005978:Glutathione