title: Carboxylic acid-promoted copper(I)-catalyzed azide-alkyne cycloaddition.
abstract: In this article, we proved that all three key steps in the catalytic cycle of CuAAC can proceed in the presence of carboxylic acids and the latter two steps can be promoted significantly by carboxylic acids. Benzoic acid showed the best promotion activity, and the acids with strong chelating ability to Cu(I) ion could not serve for this purpose. Thus, the first carboxylic acid-promoted highly efficient CuAAC was established.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
authors.forename: Changwei
authors.initials: C
authors.lastname: Shao
authors.forename: Xinyan
authors.initials: X
authors.lastname: Wang
authors.forename: Jimin
authors.initials: J
authors.lastname: Xu
authors.forename: Jichen
authors.initials: J
authors.lastname: Zhao
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D002264:Carboxylic Acids; D014230:Triazoles; D003300:Copper