title: Doppler-flow velocity indices in fetal middle cerebral artery in unilateral and bilateral mild ventriculomegaly.
abstract: OBJECTIVE
  To study the association between fetal middle cerebral artery (MCA) Doppler-flow velocity waveforms and the lateral cerebral ventricular width in fetuses diagnosed with unilateral or bilateral ventriculomegaly.
  
  
  METHODS
  A prospective cohort evaluation of the association between Doppler-flow velocity indices of the MCA and ventricular width in singleton fetuses referred because of suspected ventriculomegaly between 20 and 40 weeks' gestation. Fetuses that were diagnosed as bilateral or unilateral ventriculomegaly were assigned to the study group and those with normal ventricular width served as controls.
  
  
  RESULTS
  Of the 53 women recruited to the study, in 30 (57%) fetuses (study group) at least one ventricle ≥ 10 mm was detected, of them 10 (33%) had bilateral ventriculomegaly and 20 (67%) had unilateral ventriculomegaly. Of the 30 fetuses 29 had mild ventriculomegaly. In 23 fetuses ventricular width was <10 mm (control group). Mean MCA pulsatility index (PI) and mean peak systolic velocity (PSV) were not different between the study group and the control group (p=0.935 and p=0.743, respectively). In a linear regression model, MCA-PSV was significantly correlated with gestational age, R(2)=0.309, p<0.001.
  
  
  CONCLUSIONS
  Unilateral or bilateral mild ventriculomegaly is not associated with fetal MCA change in Doppler-flow velocity indices, suggesting different involvement of vascular component from severe ventriculomegaly.
authors.affiliation: Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Malinger
authors.forename: Ran
authors.initials: R
authors.lastname: Svirsky
authors.forename: Avi
authors.initials: A
authors.lastname: Ben-Haroush
authors.forename: Abraham
authors.initials: A
authors.lastname: Golan
authors.forename: Jacob
authors.initials: J
authors.lastname: Bar
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D015331:Cohort Studies; D005260:Female; D005333:Fetus / Q000098:blood supply*; D005865:Gestational Age; D006305:Health Status Indicators; D006801:Humans; D006849:Hydrocephalus / Q000151:congenital* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011247:Pregnancy; D012720:Severity of Illness Index; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods; D055815:Young Adult