title: Multiresponse strategies to modulate burst degradation and release from nanoparticles.
abstract: Logic gate nanoparticles, where two chemical transformations take place one after the other, were successfully formulated from a newly synthesized random co-polymer. This polymer, poly([2,2'-(propane-2,2-diylbis(oxy))bis(ethane-2,1-diyl) diacrylate ]-co-[hexane-1,6-diyl diacrylate]-4,4' trimethylene dipiperidine), (poly-β-aminoester ketal-2) contains two pH responsive moieties within its backbone. As nanoparticles they function akin to an AND logic gate. The β-aminoester backbone moiety provides a pH triggered solubility switch, only when this switch is "ON" does the ketal moiety also turn "ON" to undergo rapid acid catalyzed hydrolysis. These AND logic gate polymeric nanoparticles were prepared using an oil in water emulsion method. Their degradation in the pH range of 7.4-5 was monitored by dynamic light scattering and showed excellent stability at pH 7.4 and rapid degradation at pH 5. Our results indicate that the prepared logic gate nanoparticles may prove valuable in delivering therapeutics and diagnostics to cells and diseased tissue.
authors.affiliation: Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093-0657, USA.
authors.forename: Jagadis
authors.initials: J
authors.lastname: Sankaranarayanan
authors.forename: Enas A
authors.initials: EA
authors.lastname: Mahmoud
authors.forename: Gloria
authors.initials: G
authors.lastname: Kim
authors.forename: José M
authors.initials: JM
authors.lastname: Morachis
authors.forename: Adah
authors.initials: A
authors.lastname: Almutairi
mesh_terms: D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004952:Esters / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007249:Inflammation; D008027:Light; D008422:Materials Testing; D051379:Mice; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry; D012542:Scattering, Radiation; D012995:Solubility; D013499:Surface Properties; D013778:Tetrazolium Salts / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
chemical_list: D004952:Esters; D011108:Polymers; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue