Effect of bilateral oophorectomy on wound healing of the rabbit vagina.
We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.
Abramov
Yoram
Y
Division of Urogynecology and Reconstructive Pelvic Surgery, Carmel Medical Center, Technion University Rappaport Faculty of Medicine, Haifa, Israel. yabramov@012.net.il
Webb
Antonio R
AR
Botros
Sylvia M
SM
Goldberg
Roger P
RP
Ameer
Guillermo A
GA
Sand
Peter K
PK
D000818:Animals; D005260:Female; D010052:Ovariectomy / Q000009:adverse effects* / Q000379:methods; D011817:Rabbits; D011897:Random Allocation; D020127:Recovery of Function / Q000502:physiology*; D014621:Vagina / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*