title: Enantioselective organocatalytic Michael addition of aldehydes to trifluoroethylidene malonates.
abstract: An efficient, highly enantioselective, organocatalytic Michael addition reaction of aldehydes with trifluoroethylidene malonates is described. The asymmetric reaction provided highly optically pure β-trifluoromethyl aldehydes which can be conveniently transformed into 4,4,4-trifluoromethyl butyric acid and trifluoromethyl substituted δ-lactones without loss in enantioselectivity.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PRC.
authors.forename: Lele
authors.initials: L
authors.lastname: Wen
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
authors.forename: Long
authors.initials: L
authors.lastname: Lu