title: Unraveling the pheromone biosynthesis activating neuropeptide (PBAN) signal transduction cascade that regulates sex pheromone production in moths.
abstract: Studies over the past three decades have demonstrated that female moths usually produce sex pheromones as multicomponent blends in which the ratios of the individual components are precisely controlled, making it possible to generate species-specific pheromone blends. Most moth pheromone components are de novo synthesized from acetyl-CoA in the pheromone gland (PG) through modifications of fatty acid biosynthetic pathways. Pheromone biosynthesis activating neuropeptide (PBAN), a neurohormone produced by a cephalic organ (subesophageal ganglion) stimulates sex pheromone biosynthesis in the PG via an influx of extracellular Ca(2+). In recent years, we have expanded our knowledge of the precise mechanisms underlying silkmoth (Bombyx mori) sex pheromone production by characterizing a number of key molecules. In this review, we want to highlight our efforts in elucidating these mechanisms in B. mori and to understand how they relate more broadly to lepidopteran sex pheromone production in general.
authors.affiliation: Molecular Entomology Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohnishi
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Lee
authors.forename: J Joe
authors.initials: JJ
authors.lastname: Hull
mesh_terms: D000818:Animals; D012831:Bombyx / Q000378:metabolism*; D005260:Female; D019476:Insect Proteins / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009479:Neuropeptides / Q000502:physiology*; D012543:Scent Glands / Q000378:metabolism; D012724:Sex Attractants / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D019476:Insect Proteins; D009479:Neuropeptides; D012724:Sex Attractants; C079709:pheromone biosynthesis activating neuropeptide, Helicoverpa zea