[Research progress of platelet-rich plasma in promoting bone regeneration and repairing].
OBJECTIVE
To investigate the factors that affect platelet-rich plasma (PRP) in promoting bone regeneration and repairing.


METHODS
Recent literature was reviewed, concerning the preparations of PRP, physiological mechanism and the latest applications in orthopedic field.


RESULTS
PRP, the concentrated body of autologous platelet, was rich in platelets and was the source of autologous growth factors. Many studies had shown that PRP played an important role in promoting bone regeneration and repairing. However, a few experimental results contradicted this point. The reason might be that the biological properties of PRP were influenced by various factors, such as workmanship, vector, activation schemes, working concentration, individual difference.


CONCLUSIONS
The concentration and quality of platelet and other related factors of PRP affect the reliability of the results and conclusions. So an efficient and stable production method of PRP should be established.
Zhao
Yao
Y
Department of Orthopaedics, Affiliated Dongnan Hospital, Xiamen University, Zhangzhou Fujian 363000, PR China.
Zhai
Wenliang
W
D001861:Bone Regeneration; D053657:Platelet-Rich Plasma; D014945:Wound Healing