title: Comparison of the helical tomotherapy against the multileaf collimator-based intensity-modulated radiotherapy and 3D conformal radiation modalities in lung cancer radiotherapy.
abstract: OBJECTIVE
  The aim of this study was to compare three-dimensional (3D) conformal radiotherapy and the two different forms of IMRT in lung cancer radiotherapy.
  
  
  METHODS
  Cases of four lung cancer patients were investigated by developing a 3D conformal treatment plan, a linac MLC-based step-and-shoot IMRT plan and an HT plan for each case. With the use of the complication-free tumour control probability (P(+)) index and the uniform dose concept as the common prescription point of the plans, the different treatment plans were compared based on radiobiological measures.
  
  
  RESULTS
  The applied plan evaluation method shows the MLC-based IMRT and the HT treatment plans are almost equivalent over the clinically useful dose prescription range; however, the 3D conformal plan inferior. At the optimal dose levels, the 3D conformal treatment plans give an average P(+) of 48.1% for a effective uniform dose to the internal target volume (ITV) of 62.4 Gy, whereas the corresponding MLC-based IMRT treatment plans are more effective by an average ΔP(+) of 27.0% for a Δ effective uniform dose of 16.3 Gy. Similarly, the HT treatment plans are more effective than the 3D-conformal plans by an average ΔP(+) of 23.8% for a Δ effective uniform dose of 11.6 Gy.
  
  
  CONCLUSIONS
  A radiobiological treatment plan evaluation can provide a closer association of the delivered treatment with the clinical outcome by taking into account the dose-response relations of the irradiated tumours and normal tissues. The use of P - effective uniform dose diagrams can complement the traditional tools of evaluation to compare and effectively evaluate different treatment plans.
authors.affiliation: Department of Medical Radiation Physics, Karolinska Institutet, Stockholm University, Sweden. panayiotis.mavroidis@ki.se
authors.forename: P
authors.initials: P
authors.lastname: Mavroidis
authors.forename: C
authors.initials: C
authors.lastname: Shi
authors.forename: G A
authors.initials: GA
authors.lastname: Plataniotis
authors.forename: M G
authors.initials: MG
authors.lastname: Delichas
authors.forename: B Costa
authors.initials: BC
authors.lastname: Ferreira
authors.forename: S
authors.initials: S
authors.lastname: Rodriguez
authors.forename: B K
authors.initials: BK
authors.lastname: Lind
authors.forename: N
authors.initials: N
authors.lastname: Papanikolaou
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods* / Q000592:standards; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D036542:Tomography, Spiral Computed / Q000379:methods* / Q000592:standards