Intraoperative floppy iris syndrome associated with risperidone intake.
OBJECTIVE
Intraoperative floppy iris syndrome (IFIS) has been strongly associated with intake of selective a1 adrenergic blockers, particularly tamsulosin. Intraoperative floppy iris syndrome has also been linked to the use of other drugs with some a antagonist activity.


METHODS
We identified patients on long-term treatment with the antipsychotic agent risperidone who showed typical features of IFIS during cataract surgery.


RESULTS
We report 3 eyes in 2 patients taking risperidone in which typical features of IFIS were noted during cataract surgery.


CONCLUSIONS
Risperidone is a widely prescribed drug in psychiatric practice and has a-blocking actions as well as strong affinity for serotonin 2A receptors. Ophthalmologists should be aware of the possible association with IFIS when performing cataract surgery on patients taking risperidone.
Ford
Rebecca L
RL
Department of Ophthalmology, Whipps Cross University Hospital, London, UK. beckylouford@doctors.org.uk
Sallam
Ahmed
A
Towler
Hamish M A
HM
D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D018492:Dopamine Antagonists / Q000009:adverse effects; D065127:Dopamine D2 Receptor Antagonists; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D007499:Iris Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000139:chemically induced* / Q000175:diagnosis; D018918:Phacoemulsification; D018967:Risperidone / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000009:adverse effects; D013577:Syndrome
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D018967:Risperidone