The DAT ligand [(18)F]PR17.MZ mirrors the in vivo pharmacokinetic profile of [(11)C]cocaine with significantly improved monoamine transporter selectivity.
Riss
Patrick J
PJ
The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK. pr340@wbic.cam.ac.uk
Piel
Markus
M
Bockhart
Vanessa
V
Bausbacher
Nicole
N
Buchholz
Hans-Georg
HG
Lueddens
Hartmut
H
Roesch
Frank
F
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000737:chemistry; D003042:Cocaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005462:Fluorine Radioisotopes / Q000737:chemistry; D008024:Ligands; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D015306:Biogenic Monoamines; D002250:Carbon Radioisotopes; D003287:Contrast Media; D050483:Dopamine Plasma Membrane Transport Proteins; D005462:Fluorine Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; C555044:methyl-8-((2-(fluoromethyl)cyclopropyl)methyl)-3-phenyl-8-azabicyclo(3.2.1)octane-2-carboxylate; D003042:Cocaine