Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats.
BACKGROUND
Metabolic syndrome (MetS) has become one of the major health burdens worldwide. To date, no single pharmacological agent has been developed to correct metabolic abnormalities associated with MetS. Use of indigenous medicinal plants as alternative medicines against MetS could be beneficial due to multiple therapeutic usage, easy availability, and relatively few side effects.


OBJECTIVE
To investigate the protective effect of Clerodendron glandulosum Coleb. (Verbenaceae) aqueous leaf extract (CgE) against experimentally induced MetS in rats.


METHODS
Changes in body weight, food and fluid intake, plasma glucose, insulin, fasting insulin resistance index (FIRI), plasma total lipid profile, free fatty acids (FFA), oral glucose tolerance test (OGTT), blood pressure and vascular reactivity have been investigated in various experimental groups.


RESULTS
Fructose+CgE groups recorded significant decrement (P <0.05) in plasma glucose, insulin, FIRI, total cholesterol, triglycerides, LDL, VLDL and FFA, whereas plasma HDL level was significantly increased (P <0.05) along with an efficient clearance of glucose during OGTT and lowered area under curve values. FRU+CgE groups also showed significantly decreased (P <0.05) mean arterial blood pressure along with decreased vasoconstriction and increased vasorelaxation in response to administration of various pharmacological agents. These results were comparable with metformin treated rats.


CONCLUSIONS
C. glandulosum leaf extract ameliorates experimentally induced MetS by improving dyslipidemia and insulin resistance.


CONCLUSIONS
This study provides the first pharmacological evidence for the protective role of C. glandulosum leaves against experimentally induced MetS. Thus, therapeutic use of C. glandulosum in controlling MetS is indicated.
Jadeja
Ravirajsinh N
RN
Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M.S. University of Baroda, Vadodara, Gujarat, India.
Thounaojam
Menaka C
MC
Ansarullah
Patel
Vaibhav B
VB
Devkar
Ranjitsinh V
RV
Ramachandran
A V
AV
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D032409:Clerodendrum / Q000737:chemistry*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000188:drug therapy; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control*; D008687:Metformin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D008055:Lipids; D010936:Plant Extracts; D008687:Metformin