title: Scientific discovery workflows in bioinformatics: a scenario for the coupling of molecular regulatory pathways and gene-expression profiles.
abstract: Scientific workflow technologies and tools have become an important weapon in the arsenal of the bioinformaticians and computational biologists. To support this view we present a typical exploratory data analysis scenario involving the combination of information from Gene Regulatory Networks and gene expression data. We further describe the implementation of this scenario using the Workflow Environment implemented in the context of a large EU funded project. In this process desirable features that similar environments should offer are identified and analyzed. The ICT platform presented is evaluated using the chosen scenario as a benchmark. Finally we conclude with an outlook to future work.
authors.affiliation: Foundation for Research and Technology-Hellas, Institute of Computer Science, Heraklion, Crete, Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Kanterakis
authors.forename: Giorgos
authors.initials: G
authors.lastname: Potamias
authors.forename: Giorgos
authors.initials: G
authors.lastname: Zacharioudakis
authors.forename: Lefteris
authors.initials: L
authors.lastname: Koumakis
authors.forename: Stelios
authors.initials: S
authors.lastname: Sfakianakis
authors.forename: Manolis
authors.initials: M
authors.lastname: Tsiknakis
mesh_terms: D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods*; D053263:Gene Regulatory Networks; D012984:Software; D014584:User-Computer Interface; D057188:Workflow