[Effects of neurotrophin 3 on interdigestive migrating motor complex in rats with acute liver injury.].
OBJECTIVE
To observe the effects of neurotrophin 3(NT-3)on interdigestive migrating motor complex (MMC) in rats with D-galactosamine induced acute liver injury.


METHODS
Twenty-four specific pathogen-free purebred rats were equally randomized into control and acute liver injury groups. The control group was injected with equal volume of normal saline via tail vein. Acute liver injury model of the rats was induced by D-galactosamine injection via the tail vein in the acute liver injury group. And the indexes of interdigestive MMC before and after NT-3 injection were recorded by a polygraph and analyzed in model group. The serum NT-3 concentration was assayed in the two groups.


RESULTS
There were no significant changes of gastrointestinal MMC cycle and jejunal phase I MMC after NT-3 injection. Compared with the acute liver injury rats before NT-3 injection , the antral phases I, III and IV MMC were significantly prolonged [(577.44 ± 248.60)s vs (343.58 ± 227.30) s, (80.94 ± 21.15) s vs (24.76 ± 7.41) s, (405.69 ± 131.34) s vs (191.67 ± 128.15) s, P < 0.05] and the phase II MMC was shortened [ (883.94 ± 488.50) s vs (1519.00 ± 831.14) s, P < 0.05] in the acute liver injury group. The duodenal phases I, III and IV MMC were significantly prolonged [ (557.63 ± 335.14) s vs (309.46 ± 220.22) s,(75.91 ± 15.75) s vs (31.15 ± 13.67) s, (423.38 ± 135.22) s vs (209.77 ± 123.83) s, P < 0.05] and MMC II phase was shortened [ (748.81 ± 579.69) s vs (1535.86 ± 930.50) s, P < 0.05] in the acute liver injury rats. In addition, the jejunal MMC III and MMC IV phase was significantly prolonged [ (86.58 ± 23.40) s vs (31.41 ± 16.09) s,(385.18 ± 110.02) s vs (220.59 ± 159.30) s, P < 0.05] and phase II MMC was shortened [ (876.89 ± 652.01) s vs (1870.89 ± 1010.35) s, P < 0.05 ] in the acute liver injury rats. The serum NT-3 level was significantly higher in model group than in control group.


CONCLUSIONS
NT-3 could enhance the gastrointestinal motility in acute liver injury rats.
Liu
Mei
M
Artificial Liver Treatment and Training Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. maybelake@126.com
Xu
Wei-hong
WH
Duan
Zhong-ping
ZP
Chen
Yu
Y
Zheng
Su-jun
SJ
Liu
Xu-hua
XH
Zhao
Jun
J
Ding
Mei
M
Lv
Zhi-wu
ZW
D000818:Animals; D004063:Digestion / Q000502:physiology; D005260:Female; D005688:Galactosamine; D005769:Gastrointestinal Motility / Q000502:physiology*; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000187:drug effects* / Q000502:physiology; D020933:Neurotrophin 3 / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D020933:Neurotrophin 3; D005688:Galactosamine