title: Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma.
abstract: BACKGROUND
  Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma.
  
  
  METHODS
  Seventy-eight patients with primarily resected esophageal squamous cell carcinoma were enrolled onto this study, and gp96 expression was evaluated by immunohistochemical staining. The association of clinicopathological factors and patients' survival was calculated by univariate (log rank test) and multivariate (Cox proportional hazard regression method) analyses.
  
  
  RESULTS
  Fifty-seven (73%) of 78 cases were gp96 positive, and 21 were negative (27%). The survival of patients with gp96-negative disease was significantly shorter (5-year survival, 22.9 months) than with gp96-positive disease (45.8 months; P = 0.049), and the multivariate analysis showed that gp96 negativity is an independent risk factor for poor survival (hazard ratio, 2.577; P = 0.040). Gp96-negative cases had more metastatic lymph nodes than did negative cases, especially in T1 cases (4.8 in gp96-negative cases vs. 0.84 in gp96-positive cases; P = 0.064)
  
  
  CONCLUSIONS
  The downregulation of gp96 expression is closely correlated with poor survival in esophageal squamous cell carcinoma.
authors.affiliation: Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. yakutsu@faculty.chiba-u.jp
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Akutsu
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kano
authors.forename: Akihiro
authors.initials: A
authors.lastname: Usui
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoneyama
authors.forename: Norimasa
authors.initials: N
authors.lastname: Ikeda
authors.forename: Aki
authors.initials: A
authors.lastname: Komatsu
authors.forename: Gulbostan
authors.initials: G
authors.lastname: Yusup
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D008562:Membrane Glycoproteins; C053387:endoplasmin