Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD.
Chronic graft-versus-host disease (cGVHD) is a multi-organ disease that occurs post-hematopoietic stem cell transplantation, with the mouth being one of the most frequently affected organs. In 2009, the German-Austrian-Swiss working party on bone marrow and blood stem cell transplantation held a consensus conference to define clinical management of cGVHD. The consensus conference aimed to summarize the literature on diagnosis and topical treatment options for oral cGVHD and to provide recommendations for clinical practice, including routine dental and oral care as well as monitoring for secondary malignancies and bisphophonate-induced osteonecrosis of the jaw.
Meier
Johannes K-H
JK
Department of Cranio-Maxillo-Facial Surgery, University of Regensburg, Regensburg, Germany.
Wolff
Daniel
D
Pavletic
Steve
S
Greinix
Hildegard
H
Gosau
Martin
M
Bertz
Hartmut
H
Lee
Stefanie J
SJ
Lawitschka
Anita
A
Elad
Sharon
S
D000287:Administration, Topical; D002908:Chronic Disease; D003731:Dental Caries / Q000209:etiology; D055094:Evidence-Based Dentistry; D005938:Glucocorticoids / Q000008:administration & dosage; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007571:Jaw Diseases / Q000139:chemically induced; D009059:Mouth Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009062:Mouth Neoplasms / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000209:etiology; D019647:Oral Surgical Procedures / Q000009:adverse effects*; D010020:Osteonecrosis / Q000139:chemically induced; D010510:Periodontal Diseases / Q000209:etiology; D014987:Xerostomia / Q000150:complications / Q000188:drug therapy / Q000209:etiology
D005938:Glucocorticoids; D007166:Immunosuppressive Agents