[Dermal necrosis as cutaneous manifestation of heparin-induced thrombocytopenia II?].
Most of the rare cases of skin necrosis following heparin injections are associated with the immunologically mediated form of heparin-induced thrombocytopenia II (HIT II). We present a 62-year- old woman who developed a necrotic abdominal lesion seven days after starting daily subcutaneous injections of the low molecular heparin enoxaparin. We detected circulating antibodies against the platelet factor 4-complex but no concomitant thrombocytopenia. An isolated, antibody-mediated thrombosis of dermal vessels is the likely underlying cause of the skin necrosis in HIT II.
Illes
M
M
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universität Leipzig, Philipp-Rosenthal-Str. 23, 04103 Leipzig, Deutschland.
Klaus
S
S
Simon
J C
JC
Treudler
R
R
D000925:Anticoagulants / Q000009:adverse effects; D019457:Chromosome Breakage; D025063:Chromosome Disorders / Q000139:chemically induced; D017984:Enoxaparin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000151:congenital
D000925:Anticoagulants; D017984:Enoxaparin