title: SERS mapping of nanoparticle labels in single cells using a microfluidic chip.
abstract: We report for the first time the time-resolved mapping of intracellular nanoparticle labels from within living cells retained in a microstructured trap using Raman spectroscopy. The methods employed here also demonstrate the ability to rapidly discriminate between cell populations containing different SERS labels.
authors.affiliation: Dept. of Electronics & Electrical Engineering, University of Glasgow, Glasgow, G12 8LT, UK.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Syme
authors.forename: Narayana M S
authors.initials: NM
authors.lastname: Sirimuthu
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Faley
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Cooper
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D044085:Microfluidics / Q000295:instrumentation*; D053758:Nanoparticles; D013059:Spectrum Analysis, Raman