title: Onychomadesis after a hand, foot, and mouth disease outbreak in Spain, 2009.
abstract: Few reports exist regarding the association between onychomadesis and an enterovirus infection presenting clinically as hand, foot, and mouth disease (HFMD). In February 2009, an outbreak of HFMD occurred in a Spanish nursery school, followed by onychomadesis 36-69 days later. Twelve of 17 children with HFMD developed nail shedding; enterovirus was detected in stool samples from eight (47%) of the 17. However, in only three of the children could an enterovirus serotype coxsackievirus B1 be identified. The epidemiological results of this study confirm onychomadesis as a complication in HFMD. In future outbreaks, molecular characterization of enterovirus from appropriate clinical samples should be studied.
authors.affiliation: Virology Department, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain. mcabrerizo@isciii.es
authors.forename: M
authors.initials: M
authors.lastname: Cabrerizo
authors.forename: T
authors.initials: T
authors.lastname: De Miguel
authors.forename: A
authors.initials: A
authors.lastname: Armada
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Risco
authors.forename: A
authors.initials: A
authors.lastname: Pousa
authors.forename: G
authors.initials: G
authors.lastname: Trallero
mesh_terms: D000328:Adult; D002675:Child, Preschool; D016000:Cluster Analysis; D004196:Disease Outbreaks; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005243:Feces / Q000821:virology; D006232:Hand, Foot and Mouth Disease / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D009260:Nail Diseases / Q000453:epidemiology* / Q000209:etiology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013030:Spain / Q000453:epidemiology
chemical_list: D012367:RNA, Viral