title: In vivo efficacy of alkaline peroxide tablets and mouthwashes on Candida albicans in patients with denture stomatitis.
abstract: OBJECTIVE
  Effective cleaning of dentures is important for the maintenance of good oral hygiene for denture stomatitis patients. The in vivo efficacy of three different brands of alkaline peroxide tablets (Polident, Efferdent, and Fittydent) and two mouthwashes (CloSYS II and Corsodyl) to eliminate Candida albicans on dentures was evaluated in this in vivo study.
  
  
  METHODS
  Ninety denture wearers with clinical evidence of denture stomatitis were randomly divided into 5 test groups and 1 control group. Each group was further divided into three subgroups in which the dentures were subjected to 15-, 30-, and 60-min disinfection procedures. The dentures of each test group were treated with one of the cleaners, while those of the control group were treated with distilled water. Swab samples from the palatal surfaces (2 cm x 2 cm template delimited area) of the upper dentures were obtained before and after 15, 30, and 60 min periods of cleaner use and examined mycologically.
  
  
  RESULTS
  The reduction in the number of colony-forming units (CFU) of C. albicans before, and after 15, 30, and 60 min of use of CloSYS II and Corsodyl was significantly greater than that of the control group (p<0.05). Moreover, there was no statistically significant difference (p>0.05) among Polident, Efferdent and the control group in any of the treatment periods. Dentures treated with Fittydent appeared to have a significantly greater reduction in the number of Candida spp. only after 60 min of treatment.
  
  
  CONCLUSIONS
  The results of this study showed that the use of mouthwashes significantly reduced the number of microorganisms on dentures.
authors.affiliation: Private Dental Clinic, Ankara, Turkey.
authors.forename: Altay
authors.initials: A
authors.lastname: Uludamar
authors.forename: Yasemin Kulak
authors.initials: YK
authors.lastname: Ozkan
authors.forename: Tanju
authors.initials: T
authors.lastname: Kadir
authors.forename: Ismail
authors.initials: I
authors.lastname: Ceyhan
mesh_terms: D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001881:Borates / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects*; D002180:Candidiasis, Oral / Q000188:drug therapy*; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D015169:Colony Count, Microbial; D003820:Denture Cleansers / Q000627:therapeutic use*; D003827:Denture, Complete, Upper / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010545:Peroxides / Q000627:therapeutic use*; D013282:Stomatitis, Denture / Q000382:microbiology*; D013431:Sulfates / Q000627:therapeutic use; D013607:Tablets; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D001881:Borates; D003820:Denture Cleansers; D009067:Mouthwashes; D010545:Peroxides; D013431:Sulfates; D013607:Tablets; C102654:Polident; C010882:chlorhexidine gluconate; D002710:Chlorhexidine