Probiotics use in childhood acute diarrhea: a web-based survey.
OBJECTIVE
To evaluate practices and barriers for the use of probiotics in acute diarrhea among pediatric gastroenterologists.


BACKGROUND
Probiotics have shown significant therapeutic potential in acute infectious diarrhea. However, literature data regarding practice patterns in childhood are limited.


METHODS
A web-based 9-item survey among 1854 pediatric gastroenterologists worldwide.


RESULTS
Only 634 (34%) responded. Forty-one were excluded owing to incomplete data. Finally 593, USA (n=407) and non-USA (n=186) participants, showed: limited use in acute diarrhea (28% and 32% prospectively), prescription of a 1 strain product only by 31% and 24%, respectively, and limited utilization in ambulatory settings (43% and 51%, respectively) and in prevention of diarrhea (2.6% and 3.4%, respectively). Most participants felt there is lack of useful clinical guidelines (91% and 84%, respectively), and found this therapy effective or very effective (54% and 62%, respectively). Dosing and duration were extremely variable, the youngest age treated ranged from 2 months to 2 years of age, and adverse effects were extremely rare. These characteristics were shared by USA and by non-USA participants, with no significant differences between groups (P>0.05).


CONCLUSIONS
Many pediatric gastroenterologists worldwide do not use probiotics for acute diarrhea owing to lack of appropriate guidelines and/or poorly designed products. Therefore, worldwide health authorities should provide pharmaceutical and clinical guidelines for the appropriate use of probiotics in acute diarrhea of childhood.
Weizman
Zvi
Z
Pediatric Gastroenterology and Nutrition Unit, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel. wzvi@bgu.ac.il
D000208:Acute Disease; D001291:Attitude of Health Personnel; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000503:physiopathology / Q000628:therapy*; D005762:Gastroenterology; D014943:Global Health; D019538:Health Care Surveys; D006801:Humans; D007223:Infant; D020407:Internet; D010372:Pediatrics; D010818:Practice Patterns, Physicians'; D019936:Probiotics / Q000627:therapeutic use*