Melanocytoma of the optic disk in the Korean population.
OBJECTIVE
To report on the clinical features and the natural course of optic disk melanocytoma in the Korean population.


METHODS
A retrospective review of medical records was performed on 27 consecutive patients with optic disk melanocytoma. In cases with tumor enlargement, surface area and diameter of tumors were measured from fundus images using computer software.


RESULTS
The median age at diagnosis was 46 years with a slight female predominance (63%). The median tumor diameter and height were 3.1 mm and 1.9 mm, respectively. There were no cases with tumor-related visual loss for a median follow-up of 2 years. Tumor enlargement was observed in 4 of 21 patients (19%) that had follow-up of 1 year or more with no malignant transformation. The mean change of tumor surface area was 2.4 mm (52% increase), and the mean change of tumor diameter was 1.8 mm over a mean follow-up of 53 months in 4 cases with tumor growth. Only tumor vascularization on fluorescent angiography correlated with tumor growth (Log-rank test; P = 0.049). Kaplan-Meier survival estimated that the tumor growth was 0% at 1 year, 14% at 5 years, and 57% at 8 years.


CONCLUSIONS
Optic disk melanocytoma in the Korean population tends to be superiorly located in the optic disk, and visual prognosis was excellent. Periodic ocular examination is warranted because 57% of patients were estimated to show tumor enlargement by 8 years of follow-up.
Lee
Christopher S
CS
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Bae
Jeong H
JH
Jeon
Ik H
IH
Byeon
Suk H
SH
Koh
Hyoung J
HJ
Lee
Sung C
SC
D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000208:ethnology / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000208:ethnology / Q000473:pathology*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult