Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
The Division of Lung Diseases of the National Heart, Lung, and Blood Institute, with the Office of Rare Diseases Research, held a workshop to identify priority areas and strategic goals to enhance and accelerate research that will result in improved understanding of the lung vasculature, translational research needs, and ultimately the care of patients with pulmonary vascular diseases. Multidisciplinary experts with diverse experience in laboratory, translational, and clinical studies identified seven priority areas and discussed limitations in our current knowledge, technologies, and approaches. The focus for future research efforts include the following: (1) better characterizing vascular genotype-phenotype relationships and incorporating systems biology approaches when appropriate; (2) advancing our understanding of pulmonary vascular metabolic regulatory signaling in health and disease; (3) expanding our knowledge of the biologic relationships between the lung circulation and circulating elements, systemic vascular function, and right heart function and disease; (4) improving translational research for identifying disease-modifying therapies for the pulmonary hypertensive diseases; (5) establishing an appropriate and effective platform for advancing translational findings into clinical studies testing; and (6) developing the specific technologies and tools that will be enabling for these goals, such as question-guided imaging techniques and lung vascular investigator training programs. Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes.
Erzurum
Serpil
S
Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA.
Rounds
Sharon I
SI
Stevens
Troy
T
Aldred
Micheala
M
Aliotta
Jason
J
Archer
Stephen L
SL
Asosingh
Kewal
K
Balaban
Robert
R
Bauer
Natalie
N
Bhattacharya
Jahar
J
Bogaard
Harm
H
Choudhary
Gaurav
G
Dorn
Gerald W
GW
Dweik
Raed
R
Fagan
Karen
K
Fallon
Michael
M
Finkel
Toren
T
Geraci
Mark
M
Gladwin
Mark T
MT
Hassoun
Paul M
PM
Humbert
Marc
M
Kaminski
Naftali
N
Kawut
Steven M
SM
Loscalzo
Joseph
J
McDonald
Donald
D
McMurtry
Ivan F
IF
Newman
John
J
Nicolls
Mark
M
Rabinovitch
Marlene
M
Shizuru
Judy
J
Oka
Masahiko
M
Polgar
Peter
P
Rodman
David
D
Schumacker
Paul
P
Stenmark
Kurt
K
Tuder
Rubin
R
Voelkel
Norbert
N
Sullivan
Eugene
E
Weinshilboum
Richard
R
Yoder
Mervin C
MC
Zhao
Yingming
Y
Gail
Dorothy
D
Moore
Timothy M
TM
D035843:Biomedical Research / Q000379:methods*; D017408:Guidelines as Topic; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008171:Lung Diseases / Q000503:physiopathology*; D011652:Pulmonary Circulation