title: Low serum BDNF may indicate the development of PSD in patients with acute ischemic stroke.
abstract: OBJECTIVE
  This study was to test whether serum BDNF or tissue plasminogen activator (tPA) is correlated with the development of depression at the acute stage of stroke.
  
  
  METHODS
  Hundred ischemic stroke patients admitted to the hospital within the first 24 h of stroke onset were consecutively recruited and followed up for 14 days. The 17-item HDRS and MADRS were used to assess the severity of major depressive symptoms on day 3, day 7, and day 14 after admission. The diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression (PSD). Serum BDNF and tPA of all the patients were determined by ELISA both on day 1 and day 7 after admission. Meanwhile, 50 healthy control subjects were also recruited and underwent measurement of serum BDNF and tPA once.
  
  
  RESULTS
  We found that 37 patients (37.0%) were diagnosed of major depression at the end of the follow-up. Serum BDNF on day 1 was significantly higher in non-PSD stroke patients than in normal controls, while PSD patients had significantly lower BDNF than non-PSD patients. There was a significant negative correlation between serum BDNF and tPA on day 1 only in PSD patients (r = -0.440, p = 0.006). Serum BDNF < 5.86 ng/ml on day 1 was independently associated with incident PSD at the acute stage of stroke (OR = 28.992; 95% CI, 8.014-104.891; p < 0.001 after adjustment).
  
  
  CONCLUSIONS
  There was a significant elevation of BDNF early after ischemic stroke. Serum BDNF on day 1 after admission may predict the risk of subsequent PSD. Moreover, tPA may be involved in the change of BDNF.
authors.affiliation: Medical College, Southeast University, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Yang
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Dingming
authors.initials: D
authors.lastname: Sun
authors.forename: Zhi
authors.initials: Z
authors.lastname: Xu
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Zhang
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Li
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood / Q000523:psychology*; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D010959:Tissue Plasminogen Activator