Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity.
We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.
Breitbach
Anthony S
AS
Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.
Broderick
Adam H
AH
Jewell
Christopher M
CM
Gunasekaran
Suvai
S
Lin
Qi
Q
Lynn
David M
DM
Blackwell
Helen E
HE
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D048908:Aliivibrio fischeri / Q000187:drug effects*; D015394:Molecular Structure; D008970:Molecular Weight; D053038:Quorum Sensing / Q000187:drug effects*; D013499:Surface Properties
C088386:homoserine lactone; D015107:4-Butyrolactone