title: Association of dental fluorosis with polymorphisms of estrogen receptor gene in Chinese children.
abstract: Dental fluorosis (DF) is one of the important performances of endemic fluorosis. Some studies indicated that estrogen receptor (ESR) gene polymorphisms were associated with bone metabolism-related diseases. Therefore, it is possible that the variation in ESR genotypes will be associated with DF status. A case-control study was conducted among children aged 8-12 years with (n = 75) or without (n = 165) DF in China to investigate the relationship between ESR gene polymorphisms and DF. Gene polymorphisms were genotyped using the PCR-RFLP procedure. Children carrying R allele of ER RsaI had significantly increased risk of DF (Odds ratio (OR) = 1.821; 95% confidence interval (CI), 1.013-3.274) compared to children carrying r allele of ER RsaI in endemic fluorosis villages. For children with high-loaded fluoride status, carrying X allele of ESRα XbaI had a significantly decreased risk of DF (OR = 0.542; 95% CI, 0.314-0.936) compared to carrying x allele. This study provides the first evidence of an association between polymorphisms in the ESR gene with DF in high-fluoride-exposed populations. Further studies are needed to confirm the association.
authors.affiliation: Department of Environmental Health, Zhengzhou University School of Public Health, 100 Science Road, Zhengzhou, Henan 450001, People's Republic of China. bayue1963@hotmail.com
authors.forename: Yue
authors.initials: Y
authors.lastname: Ba
authors.forename: Huizhen
authors.initials: H
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Shibao
authors.initials: S
authors.lastname: Wen
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Yang
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Zhu
authors.forename: Lijun
authors.initials: L
authors.lastname: Ren
authors.forename: Rupu
authors.initials: R
authors.lastname: Yang
authors.forename: Cairong
authors.initials: C
authors.lastname: Zhu
authors.forename: Haixia
authors.initials: H
authors.lastname: Li
authors.forename: Xuemin
authors.initials: X
authors.lastname: Cheng
authors.forename: Liuxin
authors.initials: L
authors.lastname: Cui
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005260:Female; D009050:Fluorosis, Dental / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*
chemical_list: D011960:Receptors, Estrogen