Chemical constituents of Osyris alba and their antiparasitic activities.
Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis. Osyrisine, catechin, and catechin-3-O-α-L-rhamnopyranoside exhibited a significant level of antiparasitic activity against two parasites, Entamoeba histolytica and Giardia intestinalis.
Al-Jaber
Hala I
HI
Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan.
Mosleh
Ibrahim M
IM
Mallouh
Abdallah
A
Abu Salim
Omar M
OM
Abu Zarga
Musa H
MH
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002392:Catechin / Q000737:chemistry; D002522:Chlorocebus aethiops; D004748:Entamoeba histolytica / Q000187:drug effects*; D016829:Giardia lamblia / Q000187:drug effects*; D007597:Jordan; D008795:Metronidazole / Q000494:pharmacology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029630:Santalaceae / Q000737:chemistry*; D013237:Stereoisomerism; D014709:Vero Cells
D000977:Antiparasitic Agents; D011763:Pyrrolizidine Alkaloids; C552796:osyrisine; D008795:Metronidazole; D002392:Catechin