Yogurt containing Lactobacillus gasseri OLL 2716 (LG21 yogurt) accelerated the healing of acetic acid-induced gastric ulcer in rats.
We have reported that LG21 yogurt containing Lactobacillus gasseri OLL 2716 (LG21 yogurt) inhibits the formation of HCl-induced acute gastric lesions through the generation of prostaglandin E₂. This study aimed to determine the role of viable Lactobacillus in the healing of acetic acid-induced chronic gastric ulcer. LG21 yogurt or γ-ray radiated LG21 yogurt was administered orally twice a day for 10 d at a dose of 5 ml/kg. LG21 yogurt significantly accelerated the healing of the ulcer, but γ-ray radiated LG21 yogurt did not. However, both yogurts significantly inhibited HCl-induced gastric erosive lesions and enhanced the generation of gastric mucosal prostaglandin E₂. From the above results, it was found that viable bacteria are needed to accelerate the healing of chronic gastric ulcer, but not to inhibit gastric lesions.
Uchida
Masayuki
M
Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, Kanagawa, Japan. MASAYUKI_UCHIDA@MEIJI-MILK.COM
Shimizu
Kimiko
K
Kurakazu
Keiko
K
D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D005720:Gamma Rays; D005753:Gastric Mucosa / Q000378:metabolism; D006851:Hydrochloric Acid / Q000009:adverse effects; D007778:Lactobacillus; D019936:Probiotics / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control / Q000628:therapy*; D014945:Wound Healing; D015014:Yogurt / Q000382:microbiology*
D015232:Dinoprostone; D019342:Acetic Acid; D006851:Hydrochloric Acid