[Clinical trial on standard treatment of acute organophosphorus poisoning].
OBJECTIVE
To explore the norms of treatment of acute organophosphorus pesticide poisoning (AOPP), and observe the curative effect.


METHODS
On basis of the pre-research, the norms of treatment of AOPP were summarized, and a multi-center clinical trial was performed in 6 hospitals selected from high incidence of AOPP in Shandong Province.


RESULTS
422 patients of AOPP in 6 hospitals in observation period were treated and observed by the norms of treatment. Among them, the proportion of oral poisoning was 97.16%, middle and severe degree were 87.44%. Compared with themselves 2 years ago before standard treatment, the curative effect of the norms of treatment for AOPP was much better than before. The mortality rate of AOPP declined from 9.87% to 1.66% (Chi2 = 27.92, P < 0.01), that was much better than the average therapeutic effect level of all our province in the same period (the mortality rate: 8.92%) (Chi2 = 26.05, P < 0.01). The average amount of atropine [(37.54 +/- 17.76) mg], dropped greatly [(1280.70 +/- 69.22) mg] (U = 439.22, P < 0.01).The usage of atropine by continuous intravenous injection with venous pump was better than ordinary intravenous injection. The mean dosage of pralidoxime chloride increased twice than the previous (U = 19.48, P < 0.01). There was no drug poisoning.


CONCLUSIONS
The standard treatment of AOPP is urgently needed in our country, especially in rural area. By this trial, the satisfactory effect of the norms of treatment for AOPP summarized is observed and it reduces the fatality rate remarkably.
Yan
Yong-Jian
YJ
Shandong Academy of Labour Hygiene and Occupational Disease, Jinan 250002, China.
Li
Xiu-Ju
XJ
Ning
Guo-Ying
GY
Zhao
Xue-Bin
XB
Pan
Yong-Feng
YF
Yan
Xiao-Yong
XY
Li
Zhi-Hong
ZH
Zhang
Xiu-Wei
XW
Sun
Ming-Xia
MX
Li
Li
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D010575:Pesticides / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy*; D059039:Standard of Care / Q000592:standards*; D055815:Young Adult
D010575:Pesticides