The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection.
BACKGROUND
The natural history of hepatitis B virus (HBV) is complex and influenced by the level of viral replication and host factors. The hepatoprotective role of high density lipoproteins (HDL) and adiponectin as host factors on HBV persistence is less well understood.


METHODS
To investigate correlation between HBV DNA level with clinical parameters in patients with chronic hepatitis B, 92 male subjects with HBV infection without any risk factors for diabetes were enrolled in this study. Age and BMI of the study population were matched and HBV DNA, ALT, tumor necrosis factor alpha (TNF-α), adiponectin and lipid levels was measured.


RESULTS
Serum HBV DNA correlated inversely with serum HDL level (r = -0.23; P = 0.014). The median of log copies/ml for HBV DNA (3.67) was considered as cut off point. Patients with HBV DNA level higher than cut off point had lower adiponectin (8.7 ± 5.3 vs 10.7 ± 4.9 μg/ml p = 0.05). Also, adiponectin had a negative correlation with TNF-α (r = -0.21, P = 0.04) and positive correlations with HDL (r = 0.18, P = 0.043). Multivariate regression models show that serum HDL level is an independent factor to predict serum HBV DNA.


CONCLUSIONS
Our findings showed that higher HBV DNA levels are associated with lower HDL and adiponectin but induced TNF-alpha values.
Mohamadkhani
Ashraf
A
Epidemiology and social medicine department, Ilam University of Medical sciences, Ilam, Iran.
Sayemiri
Kourosh
K
Ghanbari
Reza
R
Elahi
Elham
E
Poustchi
Hossein
H
Montazeri
Ghodratollah
G
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D004279:DNA, Viral / Q000097:blood*; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000473:pathology / Q000503:physiopathology* / Q000821:virology*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014779:Virus Replication
C499918:ADIPOQ protein, human; D052242:Adiponectin; D004279:DNA, Viral; D008075:Lipoproteins, HDL; D014409:Tumor Necrosis Factor-alpha; D000410:Alanine Transaminase