title: Anti-influenza virus compound from Streptomyces sp. RI18.
abstract: Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp. RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.
authors.affiliation: Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan. motoki-takagi@aist.go.jp
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Motohashi
authors.forename: Aya
authors.initials: A
authors.lastname: Nagai
authors.forename: Miho
authors.initials: M
authors.lastname: Izumikawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Fuse
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Iwase
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Nagata
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000187:drug effects*; D011744:Pyrimidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; C555155:JBIR-68; D009005:Monosaccharides; D011744:Pyrimidinones