A highly selective and general palladium catalyst for the oxidative Heck reaction of electronically nonbiased olefins.
A general, highly selective oxidative Heck reaction is reported. The reaction is high-yielding under mild conditions without the need for base or high temperatures, and the selectivity is excellent, without the requirement for electronically biased olefins or other specific directing groups. A preliminary mechanistic investigation suggests that the unusually high selectivity may be due to the catalyst's sensitivity to C-H bond strength in the selectivity-determining β-hydride elimination step.
Werner
Erik W
EW
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
Sigman
Matthew S
MS
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D010165:Palladium