title: Helicobacter pylori infection: protective against increased interdialytic weight gain in asymptomatic hemodialysis patients?
abstract: OBJECTIVE
  Infection with Helicobacter pylori, which induces persistent and uncontrolled gastric inflammation leading to decreased appetite, might be protective against obesity. There is a close relationship between interdialytic weight gain (IDWG) and nutritional parameters, confirming the role of IDWG as a marker of calorie and protein intake in hemodialysis (HD) patients. Hypothesis of the present study was that infection with H pylori in subjects with uremia might cause inflammation, diminished appetite, anorexia, and decreased IDWG.
  
  
  METHODS
  A cross-sectional study was conducted.
  
  
  METHODS
  This trial involved HD patients from a state hospital.
  
  
  METHODS
  Demographic, laboratory, and clinical parameters were collected. All patients were clinically stable and euvolemic and their average IDWG percent was calculated. Malnutrition inflammation score, spKt/V, and normalized protein equivalent of total nitrogen appearance were determined. Patients were asked to rate their appetite status from 1 to 5 on a Likert scale (very good, good, fair, poor, and very poor appetite, respectively). An H pylori infection was detected by the H pylori stool antigen (HpSA) in all the patients.
  
  
  RESULTS
  HpSA was positive in 18 (30%) patients. None of the demographic and laboratory parameters differed between patients infected with HpSA and the noninfected patients. Stepwise linear regression analysis of independent factors related with IDWG% revealed that daily urine output (β = -0.432, P < .0001), serum phosphorus (β = +0.343, P = .004), and hemoglobin (β = +0.358, P = .003) were related with IDWG%.
  
  
  CONCLUSIONS
  Infection with H pylori is not related with IDWG% and nutritional parameters in HD patients.
authors.affiliation: Department of Nephrology, Zonguldak Atatürk Government Hospital, Zonguldak, Turkey. afsarbrs@yahoo.com
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.forename: Rengin
authors.initials: R
authors.lastname: Elsurer
authors.forename: Bulent
authors.initials: B
authors.lastname: Huddam
authors.forename: Caner
authors.initials: C
authors.lastname: Erden
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D003430:Cross-Sectional Studies; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D016014:Linear Models; D008297:Male; D044342:Malnutrition / Q000150:complications; D008875:Middle Aged; D009752:Nutritional Status; D015995:Prevalence; D006435:Renal Dialysis; D015430:Weight Gain
chemical_list: D015415:Biomarkers; D004044:Dietary Proteins