title: Temporo-mesial extraventricular neurocytoma and cortical dysplasia in focal temporal lobe epilepsy.
abstract: We describe a 17-year-old boy with a left extraventricular temporo-mesial neurocytoma associated with cortical dysplasia causing focal pharmacoresistant temporal lobe epilepsy. He presented with a long history of medically refractory, temporal complex partial seizures. MRI showed a left temporo-mesial lesion suspect to be a low-grade tumor. Based on the pre-operative non-invasive neurophysiological studies, the patient underwent a left tailored temporal antero-mesial resection. Histopathological examination showed an extraventricular neurocytoma associated with architectural dysplasia (Type 1a) of the temporal pole. The patient was seizure-free at 2 years follow-up. Extraventricular neurocytomas must be considered in the differential diagnosis of the plethora of low-grade tumors associated with focal epilepsy that typically involve the temporal lobe, and are frequently associated with focal cortical dysplasia.
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Bellaria Hospital, Via Altura 3, Bologna 40139, Italy. giulioni.m@tiscali.it
authors.forename: Marco
authors.initials: M
authors.lastname: Giulioni
authors.forename: Matteo
authors.initials: M
authors.lastname: Martinoni
authors.forename: Guido
authors.initials: G
authors.lastname: Rubboli
authors.forename: Gianluca
authors.initials: G
authors.lastname: Marucci
authors.forename: Anna Federica
authors.initials: AF
authors.lastname: Marliani
authors.forename: Stella
authors.initials: S
authors.lastname: Battaglia
authors.forename: Filippo
authors.initials: F
authors.lastname: Badaloni
authors.forename: Eugenio
authors.initials: E
authors.lastname: Pozzati
authors.forename: Fabio
authors.initials: F
authors.lastname: Calbucci
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology / Q000601:surgery; D018306:Neurocytoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome