Effects of metformin on the reproductive system of androgenized female rats.
Metformin improved the glucose rate and the homeostasis model assessment-insulin resistance (HOMA-IR) index and caused partial reversion of ovaries and uterine morphology in female rats androgenized with testosterone.
Mahamed
Roberta Rassi
RR
Gynecology Department, Federal University of São Paulo, São Paulo, Brazil.
Maganhin
Carla Cristina
CC
Simões
Ricardo Santos
RS
de Jesus Simões
Manuel
M
Baracat
Edmund Chada
EC
Soares
José Maria
JM
D000818:Animals; D005260:Female; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology*; D014770:Virilism / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D008687:Metformin