Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.
New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.
Galibert
Mathieu
M
Département de Chimie Moléculaire, UMR CNRS/UJF 5250, ICMG FR 2607, 570 rue de la chimie, BP 53, 38041 Grenoble cedex 9, France.
Sancey
Lucie
L
Renaudet
Olivier
O
Coll
Jean-Luc
JL
Dumy
Pascal
P
Boturyn
Didier
D
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry
D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid