Anti-influenza virus compound from Streptomyces sp. RI18.
Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp. RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.
Takagi
Motoki
M
Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan. motoki-takagi@aist.go.jp
Motohashi
Keiichiro
K
Nagai
Aya
A
Izumikawa
Miho
M
Tanaka
Masahiro
M
Fuse
Shinichiro
S
Doi
Takayuki
T
Iwase
Keiichiro
K
Kawaguchi
Atsushi
A
Nagata
Kyosuke
K
Takahashi
Takashi
T
Shin-ya
Kazuo
K
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000187:drug effects*; D011744:Pyrimidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
D000998:Antiviral Agents; C555155:JBIR-68; D009005:Monosaccharides; D011744:Pyrimidinones