title: Home intervention improves cognitive and social-emotional scores in iron-deficient anemic infants.
abstract: BACKGROUND
  Iron-deficiency anemia (IDA) is associated with alterations in infant behavior and development that may not be corrected with iron therapy.
  
  
  OBJECTIVE
  To determine if a home-based intervention to foster child development improves behavior and development of infants with IDA.
  
  
  METHODS
  Infants with IDA and nonanemic infants aged 6 and 12 months were treated with oral iron and randomly assigned to a year of surveillance or intervention. Infants in the surveillance group were visited weekly, and information on iron intake, feeding, and health were recorded. Infants in the intervention were visited weekly, and the home visits included an hour-long program to foster child development by providing support to the mother-infant relationship. The number of infants enrolled was 128 (66 who received intervention) and 149 (70 intervention) at 6 and 12 months, respectively. Psychologists who were unaware of iron status and intervention assignment assessed infants' cognitive, motor, and social-emotional development (Bayley Scales) at the beginning, midpoint, and end of the year; 116 6-month-olds and 134 12-month-olds had at least 2 assessments. Hierarchical linear modeling was used to analyze change over time.
  
  
  RESULTS
  Infants with IDA, regardless of enrollment age, were rated as less positive in social-emotional behavior at baseline. There were significant interactions between iron status and intervention associated with change in cognitive performance and positive social-emotional behavior. Infants with IDA who received intervention had developmental trajectories comparable to those of nonanemic infants in the intervention and surveillance groups, but these infants did not catch up in social-emotional behavior. Infants with IDA who received surveillance showed less increase in cognitive scores and had declines in positive social-emotional ratings.
  
  
  CONCLUSIONS
  Home-based intervention to foster child development improved cognitive and social-emotional scores in infants with IDA, but social-emotional differences remained between infants with IDA and those without IDA.
authors.affiliation: Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, 300 N Ingalls, University of Michigan, Ann Arbor, MI 48109-5406, USA. blozoff@umich.edu
authors.forename: Betsy
authors.initials: B
authors.lastname: Lozoff
authors.forename: Julia B
authors.initials: JB
authors.lastname: Smith
authors.forename: Katy M
authors.initials: KM
authors.lastname: Clark
authors.forename: Carmen Gloria
authors.initials: CG
authors.lastname: Perales
authors.forename: Francisca
authors.initials: F
authors.lastname: Rivera
authors.forename: Marcela
authors.initials: M
authors.lastname: Castillo
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000628:therapy*; D002657:Child Development; D003150:Community Health Workers; D005296:Ferrous Compounds / Q000627:therapeutic use; D006792:House Calls; D006801:Humans; D007223:Infant; D018730:Infant Behavior; D009034:Mother-Child Relations; D016037:Single-Blind Method
chemical_list: D005296:Ferrous Compounds; C020748:ferrous sulfate