Site-specific introduction of gold-carbenoids by intermolecular oxidation of ynamides or ynol ethers.
Ynamides and ynol ethers undergo intermolecular gold-catalysed reaction with a nucleophilic oxidant to access metal-carbenoid reactivity patterns. A site-specific oxidation/1,2-insertion cascade is used for a general access to functionalised α,β-unsaturated carboxylic acid derivatives and vinylogous carbimates.
Davies
Paul W
PW
School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK. p.w.davies@bham.ac.uk
Cremonesi
Alex
A
Martin
Nicolas
N
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000577:Amides; D004952:Esters; D004987:Ethers; D007094:Imides; C030011:carbene; D006046:Gold; D008697:Methane