Neural representation during visually guided reaching in macaque posterior parietal cortex.
Visually guided hand movements in primates require an interconnected network of various cortical areas. Single unit firing rate from area 7a and dorsal prelunate (DP) neurons of macaque posterior parietal cortex (PPC) was recorded during reaching movements to targets at variable locations and under different eye position conditions. In the eye position-varied task, the reach target was always foveated; thus eye position varied with reach target location. In the retinal-varied task, the monkey reached to targets at variable retinotopic locations while eye position was kept constant in the center. Spatial tuning was examined with respect to temporal (task epoch) and contextual (task condition) aspects, and response fields were compared. The analysis showed distinct tuning types. The majority of neurons changed their gain field tuning and retinotopic tuning between different phases of the task. Between the onset of visual stimulation and the preparatory phase (before the go signal), about one half the neurons altered their firing rate significantly. Spatial response fields during preparation and initiation epochs were strongly influenced by the task condition (eye position varied vs. retinal varied), supporting a strong role of eye position during visually guided reaching. DP neurons, classically considered visual, showed reach related modulation similar to 7a neurons. This study shows that both area 7a and DP are modulated during reaching behavior in primates. The various tuning types in both areas suggest distinct populations recruiting different circuits during visually guided reaching.
Heider
Barbara
B
Ctr. for Molecular and Behavioral Neuroscience, Rutgers Univ., 197 University Ave., Newark, NJ 07102, USA. barbara@cortex.rutgers.edu
Karnik
Anushree
A
Ramalingam
Nirmala
N
Siegel
Ralph M
RM
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular / Q000502:physiology; D006225:Hand / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology*