title: Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters.
abstract: The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.
authors.affiliation: Freie Universität Berlin, Institut für Chemie und Biochemie, Takustr. 3, 14195 Berlin, Germany.
authors.forename: Ina
authors.initials: I
authors.lastname: Wilkening
authors.forename: Giuseppe
authors.initials: G
authors.lastname: del Signore
authors.forename: Christian P R
authors.initials: CP
authors.lastname: Hackenberger
mesh_terms: D000577:Amides / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000737:chemistry*; D010721:Phosphinic Acids / Q000737:chemistry*; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D004952:Esters; D017646:Organosilicon Compounds; D010721:Phosphinic Acids; D010748:Phosphopeptides