title: Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants.
abstract: OBJECTIVE
  To evaluate whether pasteurized donor human milk meets the nutritional needs of preterm infants in terms of free fatty acid and amino acid contents.
  
  
  METHODS
  Milk samples were prospectively collected from 39 donors to the Mothers' Milk Bank of Ohio. The fatty acid and amino acid compositions in donor milk samples were measured before and after pasteurization, and values were compared with previously published findings and preterm infant nutrition guidelines. The nutritional adequacy of donor milk for preterm infants was based on estimated daily intake of 150 mL/kg. Statistical significance was adjusted to account for multiple comparisons.
  
  
  RESULTS
  Pasteurization did not appreciably affect donor milk composition. Docosahexaenoic acid level (0.1 mol wt %), and concentrations of glycine, aspartate, valine, phenylalanine, proline, lysine, arginine, serine, and histidine in donor milk were all significantly lower than previously reported concentrations in milk.
  
  
  CONCLUSIONS
  Donor milk is not substantially affected by pasteurization, but has low concentrations of docosahexaenoic acid and amino acids. Targeted nutritional supplementation of human donor milk for feeding preterm infants might be warranted.
authors.affiliation: Neonatal Nutrition Team, Ohio State University, Columbus, OH 43205, USA. Christina.Valentine@nationwidechildrens.org
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Valentine
authors.forename: Georgia
authors.initials: G
authors.lastname: Morrow
authors.forename: Soledad
authors.initials: S
authors.lastname: Fernandez
authors.forename: Parul
authors.initials: P
authors.lastname: Gulati
authors.forename: Dennis
authors.initials: D
authors.lastname: Bartholomew
authors.forename: Don
authors.initials: D
authors.lastname: Long
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Welty
authors.forename: Ardythe L
authors.initials: AL
authors.lastname: Morrow
authors.forename: Lynette K
authors.initials: LK
authors.lastname: Rogers
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000032:analysis*; D004281:Docosahexaenoic Acids / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008895:Milk, Human / Q000737:chemistry*; D011446:Prospective Studies
chemical_list: D000596:Amino Acids; D004281:Docosahexaenoic Acids