title: Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report.
abstract: Selective serotonin re-uptake inhibitors (SSRIs) are widely used in the community for treating many forms of mental illnesses. Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose. Data on citalopram overdose-induced metabolic acidosis are scarce. There have been only three cases of metabolic acidosis reported in the literature due to citalopram overdose in humans and we are reporting the fourth one. We report a case of citalopram overdose with metabolic acidosis and generalized seizure. To our best knowledge, this is the first case reported in Saudi Arabia.
authors.affiliation: Department of Medicine, Division of Internal Medicine, King Abdulaziz Medical City, P.O. Box 22490, Riyadh 11426, Kingdom of Saudi Arabia. salihbinsalih@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Bin Salih
authors.forename: M
authors.initials: M
authors.lastname: Al Qahtani
authors.forename: T
authors.initials: T
authors.lastname: Al Anazi
authors.forename: M
authors.initials: M
authors.lastname: Al Hussein
authors.forename: H
authors.initials: H
authors.lastname: Al Hayyan
authors.forename: H
authors.initials: H
authors.lastname: Al Modaimegh
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000188:drug therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D015283:Citalopram / Q000506:poisoning* / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning* / Q000627:therapeutic use; D013406:Suicide, Attempted; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D015283:Citalopram; D008140:Lorazepam; D017367:Selective Serotonin Reuptake Inhibitors