Use of the adamantane structure in medicinal chemistry.
This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.
Lamoureux
Guy
G
Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica, San José, Costa Rica. guy.lamoureux@ucr.ac.cr
Artavia
Graciela
G
D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D006801:Humans; D008954:Models, Biological; D009975:Orthomyxoviridae / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D016194:Receptors, N-Methyl-D-Aspartate; D000218:Adamantane