title: Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice.
abstract: An ethanol extract of fucoxanthin-rich seaweed was examined for its effectiveness as a nutraceutical for body fat-lowering agent and for an antiobese effect based on mode of actions in C57BL/6J mice. Animals were randomized to receive a semi-purified high-fat diet (20% dietary fat, 10% corn oil and 10% lard) supplemented with 0.2% conjugated linoleic acid (CLA) as the positive control, 1.43% or 5.72% fucoxanthin-rich seaweed ethanol extract (Fx-SEE), equivalent to 0.05% or 0.2% dietary fucoxanthin for six weeks. Results showed that supplementation with both doses of Fx-SEE significantly reduced body and abdominal white adipose tissue (WAT) weights, plasma and hepatic triglyceride (TG), and/or cholesterol concentrations compared to the high-fat control group. Activities of adipocytic fatty acid (FA) synthesis, hepatic FA and TG synthesis, and cholesterol-regulating enzyme were also lowered by Fx-SEE supplement. Concentrations of plasma high-density lipoprotein-cholesterol, fecal TG and cholesterol, as well as FA oxidation enzyme activity and UCP1 mRNA expression in epididymal WAT were significantly higher in the Fx-SEE groups than in the high-fat control group. CLA treatment reduced the body weight gain and plasma TG concentration. Overall, these results indicate that Fx-SEE affects the plasma and hepatic lipid profile, fecal lipids and body fat mass, and alters hepatic cholesterol metabolism, FA synthesis and lipid absorption.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Myoung-Nam
authors.initials: MN
authors.lastname: Woo
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Shin
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism; D019587:Dietary Supplements; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism / Q000628:therapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D012624:Seaweed / Q000378:metabolism*; D015430:Weight Gain; D024341:Xanthophylls / Q000494:pharmacology*
chemical_list: D019440:Anti-Obesity Agents; D004041:Dietary Fats; D008055:Lipids; D010936:Plant Extracts; D024341:Xanthophylls; C025164:fucoxanthin; D002784:Cholesterol