Effects of ApoE4 and maternal history of dementia on hippocampal atrophy.
We applied an automated hippocampal segmentation technique based on adaptive boosting (AdaBoost) to the 1.5 T magnetic resonance imaging (MRI) baseline and 1-year follow-up data of 243 subjects with mild cognitive impairment (MCI), 96 with Alzheimer's disease (AD), and 145 normal controls (NC) scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). MCI subjects with positive maternal history of dementia had smaller hippocampal volumes at baseline and at follow-up, and greater 12-month atrophy rates than subjects with negative maternal history. Three-dimensional maps and volumetric multiple regression analyses demonstrated a significant effect of positive maternal history of dementia on hippocampal atrophy in MCI and AD after controlling for age, ApoE4 genotype, and paternal history of dementia, respectively. ApoE4 showed an independent effect on hippocampal atrophy in MCI and AD and in the pooled sample.
Andrawis
John P
JP
Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
Hwang
Kristy S
KS
Green
Amity E
AE
Kotlerman
Jenny
J
Elashoff
David
D
Morra
Jonathan H
JH
Cummings
Jeffrey L
JL
Toga
Arthur W
AW
Thompson
Paul M
PM
Apostolova
Liana G
LG
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D053327:Apolipoprotein E4 / Q000235:genetics / Q000502:physiology*; D001284:Atrophy; D003704:Dementia / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers; D059906:Neuroimaging / Q000639:trends
D053327:Apolipoprotein E4; D005819:Genetic Markers