title: Acute myelogenous leukemia in a patient with severe factor IX deficiency.
abstract: We present a case of acute myelogenous leukemia in a patient with severe hemophilia and our approach to the prevention of bleeding complications during chemotherapy. In the few reports of acute leukemia occurring in patients with hemophilia, management of bleeding has mostly consisted of replacement of factor and platelets on demand. By prophylactically treating our patient with Factor IX at 50% correction three times per week and maintaining his platelet count above 30 × 10(3)/mm(3), bleeding complications were avoided. However, due to the rarity of this combination, it is difficult to draw a best practice recommendation.
authors.affiliation: Department of Pediatrics, Wilford Hall Medical Center, San Antonio, Texas, USA. cheryllsiebert@hotmail.com
authors.forename: Cheryll
authors.initials: C
authors.lastname: Clark
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Gidvani
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D005164:Factor IX / Q000627:therapeutic use; D002836:Hemophilia B / Q000150:complications* / Q000628:therapy*; D006470:Hemorrhage / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D017713:Platelet Transfusion; D011292:Premedication; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D005164:Factor IX