title: Development of photostable near-infrared cyanine dyes.
abstract: With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standard IndoCyanine Green (ICG).
authors.affiliation: Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543, Singapore.
authors.forename: Animesh
authors.initials: A
authors.lastname: Samanta
authors.forename: Marc
authors.initials: M
authors.lastname: Vendrell
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Das
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D002232:Carbocyanines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D002232:Carbocyanines; D004396:Coloring Agents