Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality.
Hemophagocytic lymphohistiocytosis (HLH) is difficult to diagnose and treat. Highly elevated ferritin is strongly associated with HLH and levels may provide a prognostic marker. A comprehensive review of ferritin data from our patients during treatment was analyzed with respect to mortality. A patient was 17 times more likely to die when percent ferritin decrease was less than 50% as compared to a 96% or greater decrease as indicated with multivariate logistic modeling. Higher maximum ferritin levels in the first 3 weeks also contributed to the odds of death (OR = 5.6; 90% CI = 1.2-24.9). Regular ferritin measurements may be useful predicting outcomes in HLH patients.
Lin
Tiffany F
TF
Baylor College of Medicine, Department of Pediatrics, Texas Children's Cancer Center/Hematology Service, and Epidemiology Center, Houston, TX, USA.
Ferlic-Stark
Laura L
LL
Allen
Carl E
CE
Kozinetz
Claudia A
CA
McClain
Kenneth L
KL
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D009026:Mortality; D016017:Odds Ratio; D011237:Predictive Value of Tests
D015415:Biomarkers; D005293:Ferritins