Oestrogen shuts the door on SOX9.
Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing nuclear localization of SOX9, a master regulator of the testis differentiation pathway. See research article http://www.biomedcentral.com/1741-7007/8/113.
Mork
Lindsey
L
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Capel
Blanche
B
D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D006066:Gonads / Q000254:growth & development* / Q000378:metabolism; D007614:Macropodidae / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D055758:SOX9 Transcription Factor / Q000378:metabolism*
D004967:Estrogens; D055758:SOX9 Transcription Factor