Marine natural products targeting phospholipases A2.
Phospholipases A(2) (PLA(2)s) form a family of enzymes catalyzing the hydrolysis of membrane phospholipids into arachidonic acid, which is the major precursor of pro-inflammatory eicosanoids. As a result, PLA(2)s have been considered as potential targets in anti-inflammatory drug discovery. Marine natural products are a rich source of bioactive compounds, including PLA(2) inhibitors. Here, we review the properties of marine PLA(2) inhibitors identified since the first discovery of PLA(2) inhibitory activity in the marine natural product manoalide in the mid 1980s.
Folmer
Florence
F
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
Jaspars
Marcel
M
Schumacher
Marc
M
Dicato
Mario
M
Diederich
Marc
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D064801:Phospholipase A2 Inhibitors; D012717:Sesquiterpenes / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D001688:Biological Products; D004224:Diterpenes; D064801:Phospholipase A2 Inhibitors; D012717:Sesquiterpenes; D013729:Terpenes; C045673:manoalide