title: Formal total synthesis of okadaic acid via regiocontrolled gold(I)-catalyzed spiroketalizations.
abstract: Both C19 and C34 spiroketal domains of okadaic acid were assembled using gold(I) chloride catalyzed spiroketalizations, and the two resulting fragments were coupled to give the C15-C38 fragment of okadaic acid, a known intermediate for the total synthesis of this important natural product.
authors.affiliation: Department of Chemistry, The Ohio State University, Columbus, Ohio 43210-1185, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Fang
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Pang
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Forsyth
mesh_terms: D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D019319:Okadaic Acid / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D005663:Furans; D013141:Spiro Compounds; C520774:spiroketal; D019319:Okadaic Acid; D006046:Gold