Natural and synthetic antioxidants: an updated overview.
Abstract The current understanding of the complex role of ROS in the organism and pathological sequelae of oxidative stress points to the necessity of comprehensive studies of antioxidant reactivities and interactions with cellular constituents. Studies of antioxidants performed within the COST B-35 action has concerned the search for new natural antioxidants, synthesis of new antioxidant compounds and evaluation and elucidation of mechanisms of action of both natural and synthetic antioxidants. Representative studies presented in the review concern antioxidant properties of various kinds of tea, the search for new antioxidants of herbal origin, modification of tocopherols and their use in combination with selenium and properties of two promising groups of synthetic antioxidants: derivatives of stobadine and derivatives of 1,4-dihydropyridine.
Augustyniak
Agnieszka
A
Department of Analytical Chemistry, Medical University of Białystok, 14, Poland.
Bartosz
Grzegorz
G
Cipak
Ana
A
Duburs
Gunars
G
Horáková
L'ubica
L
Luczaj
Wojciech
W
Majekova
Magdalena
M
Odysseos
Andreani D
AD
Rackova
Lucia
L
Skrzydlewska
Elzbieta
E
Stefek
Milan
M
Strosová
Miriam
M
Tirzitis
Gunars
G
Venskutonis
Petras Rimantas
PR
Viskupicova
Jana
J
Vraka
Panagiota S
PS
Zarković
Neven
N
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000494:pharmacology; D004095:Dihydropyridines / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology; D018036:Selenium Compounds / Q000737:chemistry / Q000494:pharmacology; D013662:Tea / Q000737:chemistry; D024505:Tocopherols / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D002243:Carbolines; D004095:Dihydropyridines; D028321:Plant Preparations; D018036:Selenium Compounds; D013662:Tea; C038806:1,4-dihydropyridine; D024505:Tocopherols; C100106:dicarbine