title: Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.
abstract: Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC(50) = 3.70 μM), palmyrolide A (1) showed a relatively potent sodium channel blocking activity in neuro-2a cells (IC(50) = 5.2 μM), without appreciable cytotoxicity.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92037, USA.
authors.forename: Alban R
authors.initials: AR
authors.lastname: Pereira
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Cao
authors.forename: Niclas
authors.initials: N
authors.lastname: Engene
authors.forename: Irma E
authors.initials: IE
authors.lastname: Soria-Mercado
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Murray
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D000818:Animals; D002460:Cell Line; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry*; D006801:Humans; D018942:Macrolides / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D011077:Polychaeta / Q000382:microbiology
chemical_list: D047630:Depsipeptides; D018942:Macrolides; C548953:palmyramide A