Considerations in the design of vaccines that induce CD8 T cell mediated immunity.
The protective capacity of many currently used vaccines is based on induction of neutralizing antibodies. Many pathogens, however, have adapted themselves in different ways to escape antibody-based immune protection. In particular, for those infections against which conventional neutralizing antibody-based vaccinations appear challenging, CD8 T-cells are considered to be promising candidates for vaccine targeting. The design of vaccines that induce robust and long-lasting protective CD8 T-cell responses however imposes new challenges, as many factors such as kinetics and efficiency of antigen-processing and presentation by antigen presenting cells, T-cell repertoire and cytokine environment during T cell priming contribute to the specificity and functionality of CD8 T-cell responses. In the following, we review the most prominent aspects that underlie CD8 T-cell induction and discuss how this knowledge may help to improve the design of efficient CD8 T-cell inducing vaccines.
Zaiss
D M W
DM
Division of Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Boog
C J P
CJ
van Eden
W
W
Sijts
A J A M
AJ
D057134:Antibodies, Neutralizing / Q000276:immunology; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015195:Drug Design; D016056:Immunodominant Epitopes / Q000276:immunology; D007156:Immunologic Memory; D014612:Vaccines / Q000276:immunology*
D057134:Antibodies, Neutralizing; D016056:Immunodominant Epitopes; D014612:Vaccines