title: The participation of cytochrome P450 3A4 in clozapine biotransformation is detected in people with schizophrenia by high-throughput in vivo phenotyping.
authors.forename: Sussan
authors.initials: S
authors.lastname: Ghassabian
authors.forename: Manoranjenni
authors.initials: M
authors.lastname: Chetty
authors.forename: Bruce N
authors.initials: BN
authors.lastname: Tattam
authors.forename: John
authors.initials: J
authors.lastname: Glen
authors.forename: Jeannie
authors.initials: J
authors.lastname: Rahme
authors.forename: Zvijezdana
authors.initials: Z
authors.lastname: Stankovic
authors.forename: Iqbal
authors.initials: I
authors.lastname: Ramzan
authors.forename: Michael
authors.initials: M
authors.lastname: Murray
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McLachlan
mesh_terms: D001711:Biotransformation; D003024:Clozapine / Q000378:metabolism* / Q000627:therapeutic use; D051544:Cytochrome P-450 CYP3A / Q000235:genetics* / Q000502:physiology; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D010641:Phenotype; D011446:Prospective Studies; D012559:Schizophrenia / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics*
chemical_list: D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D003024:Clozapine