Immunologgical self-tolerance in allophenic and embryo-aggregated mice.
Allophenic mice, supposedly containing almost equal numbers of cells derived from embryos of mouse strains C57Bl and FVB, were shown in a recent paper to grow the B16 melanoma, a long transplanted tumor of C57Bl origin, much better than did mice of either the parental C57Bl strain or the C57Bl x FVB F1 hybrid. Mice containing smaller proportions of C57Bl cells rejected the tumor. A reconsideration of these suprising data, in light of the current literature, suggests that the better growth of the tumor in the 50-50% allophenics than in the C57Bl parental strain was almost certainly caused by the tumor stimulation engendered by a weak anti-C57Bl immune reaction in the overtly healthy allophenic mice.
Prehn
Richmond T
RT
Dept of Pathology, University of Washington, 5433 South Hudson St, Seattle, WA 98118, USA. prehn@u.washington.edu
Prehn
Liisa M
LM
D000818:Animals; D002449:Cell Aggregation; D004622:Embryo, Mammalian / Q000166:cytology* / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D018448:Models, Immunological; D017711:Nonlinear Dynamics; D017634:Self Tolerance / Q000276:immunology*