title: Cerebral blood volume imaging by flat detector computed tomography in comparison to conventional multislice perfusion CT.
abstract: OBJECTIVE
  We tested the hypothesis that Flat Detector computed tomography (FD-CT) with intravenous contrast medium would allow the calculation of whole brain cerebral blood volume (CBV) mapping (FD-CBV) and would correlate with multislice Perfusion CT (PCT).
  
  
  METHODS
  Twenty five patients were investigated with FD-CBV and PCT. Correlation of the CBV maps of both techniques was carried out with measurements from six anatomical regions from both sides of the brain. Mean values of each region and the correlation coefficient were calculated. Bland-Altman analysis was performed to compare the two different imaging techniques.
  
  
  RESULTS
  The image and data quality of both PCT and FD-CBV were suitable for evaluation in all patients. The mean CBV values of FD-CBV and PCT showed only minimal differences with overlapping standard deviation. The correlation coefficient was 0.79 (p < 0.01). Bland-Altman analysis showed a mean difference of -0.077 ± 0.48 ml/100 g between FD-CBV and PCT CBV measurements, indicating that FD-CBV values were only slightly lower than those of PCT.
  
  
  CONCLUSIONS
  CBV mapping with intravenous contrast medium using Flat Detector CT compared favourably with multislice PCT. The ability to assess cerebral perfusion within the angiographic suite may improve the management of ischaemic stroke and evaluation of the efficacy of dedicated therapies.
authors.affiliation: Department of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. tobias.struffert@uk-erlangen.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Struffert
authors.forename: Yu
authors.initials: Y
authors.lastname: Deuerling-Zheng
authors.forename: Stephan
authors.initials: S
authors.lastname: Kloska
authors.forename: Tobias
authors.initials: T
authors.lastname: Engelhorn
authors.forename: Jan
authors.initials: J
authors.lastname: Boese
authors.forename: Michael
authors.initials: M
authors.lastname: Zellerhoff
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwab
authors.forename: Arnd
authors.initials: A
authors.lastname: Doerfler
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods*; D001331:Automation; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D020521:Stroke / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media