Genomic profiling of sinonasal squamous cell carcinoma.
BACKGROUND
Sinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SCC.


METHODS
DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.


RESULTS
Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13.


CONCLUSIONS
The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology.
López
Fernando
F
Department of Otolaryngology, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
Llorente
José L
JL
García-Inclán
Cristina
C
Alonso-Guervós
Marta
M
Cuesta-Albalad
Mari Paz
MP
Fresno
Manuel Florentino
MF
Alvarez-Marcos
César
C
Suárez
Carlos
C
Hermsen
Mario A
MA
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005784:Gene Amplification; D016158:Genes, p53 / Q000235:genetics*; D016678:Genome; D006258:Head and Neck Neoplasms / Q000235:genetics; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000235:genetics; D046228:Microarray Analysis; D008875:Middle Aged; D009154:Mutation; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
D014408:Biomarkers, Tumor