Debridement of the noninfected wound.
The utility of wound debridement has expanded to include the management of all chronic wounds, even in the absence of infection and gross necrosis. Biofilms, metalloproteases on the wound base, and senescent cells at the wound edge irreversibly change the physiologic features of wound healing and contribute to a pathologic, chronic inflammatory environment. The objective of this review is to provide surgeons with a basic understanding of the processes of debridement in the noninfected wound.
Cornell
Rhonda S
RS
Department of Plastic Surgery, Georgetown University School of Medicine, Washington, DC, USA.
Meyr
Andrew J
AJ
Steinberg
John S
JS
Attinger
Christopher E
CE
D003646:Debridement / Q000379:methods; D017719:Diabetic Foot / Q000382:microbiology / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000601:surgery; D009336:Necrosis / Q000601:surgery; D014945:Wound Healing; D014946:Wound Infection / Q000601:surgery