title: Total synthesis of (+)-korupensamine B via an atropselective intermolecular biaryl coupling.
abstract: The asymmetric total synthesis of nonracemic korupensamine B is reported. It includes a newly designed and highly trans-diastereoselective (>20:1 dr) route to the tetrahydroisoquinoline ring and an unprecedented atropdiastereoselective Suzuki-Miyaura coupling for construction of the fully fashioned naphthylisoquinoline framework that invokes π stacking as a possible source of stereocontrol.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
authors.forename: Shenlin
authors.initials: S
authors.lastname: Huang
authors.forename: Tue B
authors.initials: TB
authors.lastname: Petersen
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz
mesh_terms: D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007546:Isoquinolines; D009281:Naphthalenes; C110657:korupensamine A