IGF-1 and bone: New discoveries from mouse models.
Insulin-like growth factor-1 (IGF-1) plays a central role in cellular growth, differentiation, survival, and cell cycle progression. It is expressed early during development and its effects are mediated through binding to a tyrosine kinase receptor, the insulin-like growth factor-1 receptor (IGF-1R). In the circulation, the IGFs bind to IGF-binding proteins (IGFBPs), which determine their bioavailability and regulate the interaction between the IGFs and IGF-1R. Studies in animal models and in humans have established critical roles for IGFs in skeletal growth and development. In this review we present new and old findings from mouse models of the IGF system and discuss their clinical relevance to normal and pathological skeletal physiology.
Yakar
Shoshana
S
Division of Endocrinology, University of North Carolina, Chapel Hill, NC, USA. shoshana.yakar@mssm.edu
Courtland
Hayden-William
HW
Clemmons
David
D
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D004703:Endocrine System / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D023421:Models, Animal
D007334:Insulin-Like Growth Factor I