title: [The degree of coronary atherosclerosis as a marker of insulin resistance in non-diabetics].
abstract: BACKGROUND
  The metabolic syndrome and its influence on coronary artery disease development and progression remains in focus of international research debates, while insulin resistance, which represents its core, is the key component of hypertension, dyslipidaemias, glucose intolerance and obesity.
  
  
  OBJECTIVE
  The aim of this study was to establish relationship between basal glucose and insulin levels, insulin sensitivity and lipid panel and the degree of coronary atherosclerosis in nondiabetic patients.
  
  
  METHODS
  The coronary angiograms were evaluated for the presence of significant stenosis, insulin sensitivity was assessed using the intravenous glucose tolerance test with a minimal model according to Bergman, while baseline glucose (GO), insulin (10) and lipid panel measurements (TC, HDL, LDL, TG) were taken after a 12-hour fasting.
  
  
  RESULTS
  The protocol encompassed 40 patients (19 men and 21 women) treated at the Institute for Cardiovascular Diseases of the Clinical Centre of Serbia, Belgrade. All were non-diabetics who were divided into 3 groups based on their angios: Group A (6 patients, 15%, with no significant stenosis), Group B (18 patients, 45%, with a single-vessel disease) and Group C (16 patients, 40%, with multi-vessel disease). Presence of lower insulin sensitivity, higher 10 and TC in the group of patients with a more severe degree of coronary atherosclerosis (insulin sensitivity: F = 4.279, p = 0.023, A vs. C p = 0.012, B vs. C p = 0.038; 10: F = 3.461 p = 0.042, A vs. B p = 0.045, A vs. C p = 0.013; TC: F = 2.572, p = 0.09), while no significant difference was found for GO, LDL, HDL and TG.
  
  
  CONCLUSIONS
  Baseline insulinaemia, more precisely, fasting hyperinsulinaemia could be a good predictor of significant coronary atherosclerosis in non-diabetic patients, which enables a more elegant cardiometabolic risk assessment in the setting of everyday clinical practice.
authors.forename: Biljana
authors.initials: B
authors.lastname: Parapid
authors.forename: Jovica
authors.initials: J
authors.lastname: Saponjski
authors.forename: Mladen
authors.initials: M
authors.lastname: Ostojić
authors.forename: Vladan
authors.initials: V
authors.lastname: Vukcević
authors.forename: Sinisa
authors.initials: S
authors.lastname: Stojković
authors.forename: Biljana
authors.initials: B
authors.lastname: Obrenović-Kirćanski
authors.forename: Katarina
authors.initials: K
authors.lastname: Lalić
authors.forename: Sinisa
authors.initials: S
authors.lastname: Pavlović
authors.forename: Miodrag
authors.initials: M
authors.lastname: Dikić
authors.forename: Dragana
authors.initials: D
authors.lastname: Bubanja
authors.forename: Nada
authors.initials: N
authors.lastname: Kostić
authors.forename: Svetomir
authors.initials: S
authors.lastname: Dragićević
authors.forename: Natasa
authors.initials: N
authors.lastname: Milić
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Lalić
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojić
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D008055:Lipids