title: Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract.
abstract: In the present study six probiotic Lactobacillus rhamnosus strains were investigated for their ability to survive in the human upper gastrointestinal tract through a dynamic gastric model of digestion. MRS broth was used as delivery vehicle and survival was investigated during in vitro gastric and gastric plus duodenal digestion. Results highlighted that all tested strains showed good survival rate during both gastric and duodenal digestion. In particular, three strains exhibited a great survival showing a recovery percentage in the range between 117 and 276%. In agreement with survival data, high lactic acid production was detected for all strains, confirming their metabolic activity during digestion.
authors.affiliation: DOFATA, Dipartimento di Orto Floro Arboricoltura e Tecnologie Agro-alimentari, University of Catania, Catania, Italy.
authors.forename: Iole
authors.initials: I
authors.lastname: Pitino
authors.forename: Cinzia Lucia
authors.initials: CL
authors.lastname: Randazzo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Mandalari
authors.forename: Alberto
authors.initials: A
authors.lastname: Lo Curto
authors.forename: Richard Martin
authors.initials: RM
authors.lastname: Faulks
authors.forename: Yvan
authors.initials: Y
authors.lastname: Le Marc
authors.forename: Carlo
authors.initials: C
authors.lastname: Bisignano
authors.forename: Cinzia
authors.initials: C
authors.lastname: Caggia
authors.forename: Martin Sean John
authors.initials: MS
authors.lastname: Wickham
mesh_terms: D004063:Digestion; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D052201:Lacticaseibacillus rhamnosus / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism; D050296:Microbial Viability; D008954:Models, Biological; D041742:Upper Gastrointestinal Tract / Q000382:microbiology*
chemical_list: D019344:Lactic Acid