title: Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.
abstract: We investigated the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profiles and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG). ICR mice (6-8 weeks old, male) were fed BMP (0.1% or 0.3%) for 1 week, and on day 7, MSG (4 mg/g) was administered intraperitoneally to the mice. Administration of MSG resulted in a significant decrease of antioxidant biomarkers such as total glutathione level and antioxidant enzyme activities such as glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and quinone reductase (NQO1), whereas the thiobarbituric acid-reactive substances (TBARS) value was increased in liver tissue. However, BMP supplementation markedly enhanced the hepatic antioxidant enzyme activities, including GPx, GR, GST, and NQO1, whereas it lowered TBARS, compared to the MSG-treated group. Moreover, BMP supplementation decreased total cholesterol, atherogenic index, and low-density lipoprotein-cholesterol, compared to the MSG-treated group. Based on these results, it was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with MSG.
authors.affiliation: College of Pharmacy, Chungnam National University, Gyeongsan, Republic of Korea.
authors.forename: Cheon Ho
authors.initials: CH
authors.lastname: Park
authors.forename: Mi Yeon
authors.initials: MY
authors.lastname: Kim
authors.forename: Dai-Eun
authors.initials: DE
authors.lastname: Sok
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Jeung Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Mee Ree
authors.initials: MR
authors.lastname: Kim
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008107:Liver Diseases; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D036901:Petasites / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D012970:Sodium Glutamate / Q000633:toxicity*; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D016660:NAD(P)H Dehydrogenase (Quinone); D005980:Glutathione Reductase; D005982:Glutathione Transferase; D012970:Sodium Glutamate