title: Autism and X-linked hypophosphatemia: A possible association?
abstract: We herein report the joint occurrence of an autistic disorder (AD) and X-linked hypophosphatemia. X-linked hypophosphatemia (XLH), an X-linked dominant disorder, is the most common of the inherited renal phosphate wasting disorders. Autism is a pervasive developmental disorder that occurs mainly due to genetic causes. In approximately 6-15% of cases, the autistic phenotype is a part of a broader genetic condition called syndromic autism.Therefore, reports of cases with the joint occurrence of a known genetic syndrome and a diagnosis of ASD by a child psychiatrist are relevant. A joint occurrence does not, however, mean that there is always a causal link between the genetic syndrome and the autistic behavioural phenotype. In this case, there are a number of arguments countering a causal link.
authors.affiliation: University Centre Child and Adolescent Psychiatry (UCKJA), ZNA Middelheim Antwerp, University of Antwerp, CAPRI, Belgium.
authors.forename: Vermeersch
authors.initials: V
authors.lastname: Joël
authors.forename: Hellemans
authors.initials: H
authors.lastname: Hans
authors.forename: Deboutte
authors.initials: D
authors.lastname: Dirk