title: Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions.
abstract: We report a mild and environmentally benign method for the synthesis of tertiary amines using alcohols as the alkylating reagents. Not only secondary amines such as piperazines but also amino acids and amino alcohols can be N-alkylated selectively. For N,O-benzyl protected amino alcohols, both N,O-de-benzylation and N-methylation were achieved in one-pot.
authors.affiliation: Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry & Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Chu-Pei
authors.initials: CP
authors.lastname: Xu
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Xiao
authors.forename: Bi-Qin
authors.initials: BQ
authors.lastname: Zhuo
authors.forename: Yu-Huang
authors.initials: YH
authors.lastname: Wang
authors.forename: Pei-Qiang
authors.initials: PQ
authors.lastname: Huang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000477:Alkylating Agents / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D055772:Green Chemistry Technology / Q000379:methods*; D013379:Substrate Specificity
chemical_list: D000438:Alcohols; D000477:Alkylating Agents; D000588:Amines; D000596:Amino Acids