Effect of dietary fiber of "Rihane" barley grains and azoxymethane on serum and liver lipid variables in Wistar rats.
The aim of the present study is to evaluate the effects of diet enriched with dietary fiber of barley variety "Rihane" and azoxymethane on serum and liver lipid variables in male rats. Forty male rats were divided into four groups and fed on control diet or experimental diet that contained control enriched with dietary fiber of barley variety "Rihane". Animals were injected with saline (controls) or azoxymethane (20 mg/kg body weight s.c.) at 7 and 8 weeks of age. The experimental diet significantly decreased cholesterol level compared with the control diet. Rats fed with BR diet significantly increased the serum high-density lipoprotein (HDL) cholesterol and significantly decreased low-density lipoprotein (LDL) cholesterol concentrations. The experimental diet decreased the atherogenic index (p < 0.05) compared with the control diet. Whereas the azoxymethane induced a significant increase of liver lipid, serum LDL and triglyceride concentrations, but it caused a significant reduction of HDL. Consequently, the ratio of HDL/TC decreased significantly compared with the control (p < 0.05). Accordingly, these results indicated that the diet enriched with dietary fiber of barley variety "Rihane" could be effective in decreasing the atherogenic risk factors in rats whereas the use of the azoxymethane as colon-specific carcinogen substance altered the lipid metabolism.
Lahouar
Lamia
L
Unité de Recherche 03/UR/09-01 "Génome, Diagnostic Immunitaire et Valorisation", Institut Supérieur de Biotechnologie de Monastir, Rue Tahar Hadded, BP 74, Monastir 5019, Tunisia. lahouarlamia@yahoo.fr
Ghrairi
Fatma
F
El Felah
Mouldi
M
Salem
Hichem Ben
HB
Miled
Abdel Hedi
AH
Hammami
Mohamed
M
Achour
Lotfi
L
D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood; D008078:Cholesterol, LDL / Q000032:analysis / Q000097:blood; D004043:Dietary Fiber / Q000008:administration & dosage*; D002523:Edible Grain / Q000737:chemistry; D001467:Hordeum / Q000737:chemistry; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044967:Serum / Q000737:chemistry / Q000187:drug effects*; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D002273:Carcinogens; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D001397:Azoxymethane