Towards disposable sensors for drug quality control: Dextromethorphan screen- printed electrodes.
A simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen-printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10⁻⁵ to 10⁻² mol L⁻¹ with detection limit reaching 6 × 10⁻⁶ mol L⁻¹ and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h⁻¹.
Khaled
Elmorsy
E
National Research Centre, Dokki, Giza, Egypt. elmorsykhaled@yahoo.com
Hassan
H N A
HN
Mohamed
Gehad G
GG
Seleim
Aly Eldin A
AE
D003915:Dextromethorphan / Q000032:analysis*; D004566:Electrodes; D017022:Flow Injection Analysis; D004364:Pharmaceutical Preparations / Q000032:analysis; D011199:Potentiometry / Q000379:methods*; D011786:Quality Control
D004364:Pharmaceutical Preparations; D003915:Dextromethorphan