title: [Optimization of the extraction technology of total flavonoids from Mulgedium tataricum using response surface analysis].
abstract: OBJECTIVE
  Response surface analysis methodology (RSM) was used to optimize the extraction technology of total flavonoids from Mulgedium tataricum.
  
  
  METHODS
  Ethanol concentration, solvent-solid ratio, extraction temperature and extraction time were selected as influencing factors during extraction. The experiment mathematical model was arranged according to Box-Behnken central composite experiment design.
  
  
  RESULTS
  The optimal extraction conditions were as following: ethanol concentration 63.78%, solvent-solid ratio 40: 1, extraction temperature 90 degrees C, and extraction time 1.07 h, the predicted value of extraction rate of total flavonoids was 14.04% under the optimum conditions, and the experimental value was 13.79%.
  
  
  CONCLUSIONS
  The combination of Box-Behnken design and response surface analysis can well optimize the extraction technology of total flavonoids from Mulgedium tataricum.
authors.affiliation: College of Life Science and Chemistry, Tian shui Normal University, Tianshui 741001, China. egaoxy@126.com
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Gao
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Jing
authors.forename: Zu-Jun
authors.initials: ZJ
authors.lastname: Jiang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Sheng
authors.initials: S
authors.lastname: Yang
mesh_terms: D000704:Analysis of Variance; D019659:Asteraceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D000431:Ethanol / Q000737:chemistry; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D008962:Models, Theoretical; D012997:Solvents; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D012997:Solvents; D000431:Ethanol