title: [A case report of advanced gallbladder cancer with multiple liver metastases effectively treated by concentrated therapy with S-1].
abstract: A 65 -year-old male was admitted to our hospital because of epigastregia. Computed tomography (CT) and abdominal ultrasonography (AUS) revealed advanced gallbladder cancer and two S5 liver metastases. Selective gallbladder angiogram revealed his cystic vein was draining into the portal vein (P5), so cholecystectomy and S4a+S5-subsegmentectomy were performed. Pathological study of the resected specimens showed three liver metastases. After surgical resection lumbar metastasis was suspected, so radiotherapy and UFT at 300mg/day were started. Next, we started oral administration of S-1 alone (100mg/body) for 4 weeks followed by a 2-week rest period as one course. 100mg/day was changed to 80mg/body after 3 courses because of grade 2 neutropenia. A total of 31 courses of S-1 80mg/day were administered postoperatively for five years. The patient is alive and free of disease five years and ten months after the operation.
authors.affiliation: Dept. of Surgery, Toranomon Hospital, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tomizawa
authors.forename: Kazunari
authors.initials: K
authors.lastname: Sasaki
authors.forename: Masamichi
authors.initials: M
authors.lastname: Matsuda
authors.forename: Masaji
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Harushi
authors.initials: H
authors.lastname: Udagawa
authors.forename: Toshihito
authors.initials: T
authors.lastname: Sawada
authors.forename: Goro
authors.initials: G
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D004338:Drug Combinations; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid