title: Brain proton magnetic spectroscopy in long-term treatment of Wilson's disease patients.
abstract: We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson's disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated four hWD patients, with no improvement and eight with marked improvement; and eight nWD patients with marked improvement and seven with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.
authors.affiliation: II Department of Neurology, Institute of Psychiatry and Neurology, 9 Sobieskiego Str., Warsaw, Poland. beatek_ta@poczta.onet.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Tarnacka
authors.forename: Wojciech
authors.initials: W
authors.lastname: Szeszkowski
authors.forename: Marek
authors.initials: M
authors.lastname: Gołębiowski
authors.forename: Anna
authors.initials: A
authors.lastname: Członkowska
mesh_terms: D000328:Adult; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods; D011522:Protons; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011522:Protons