title: Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model.
abstract: Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Friedrich Schiller University, Jena, Germany. Gerlind.Schneider@med.uni-jena.de
authors.forename: Gerlind
authors.initials: G
authors.lastname: Schneider
authors.forename: Karin
authors.initials: K
authors.lastname: Blechschmidt
authors.forename: Dirk
authors.initials: D
authors.lastname: Linde
authors.forename: Peter
authors.initials: P
authors.lastname: Litschko
authors.forename: Thomas
authors.initials: T
authors.lastname: Körbs
authors.forename: Eggert
authors.initials: E
authors.lastname: Beleites
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D002516:Ceramics / Q000737:chemistry; D005260:Female; D005898:Glass / Q000737:chemistry; D006882:Hydroxyapatites; D008422:Materials Testing; D023421:Models, Animal; D016348:Osseointegration; D011817:Rabbits; D012886:Skull / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; C067324:Bioverit; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C475044:hydroxyapatite cement; C020243:calcium phosphate