title: Evaluation of an MR-compatible blood sampler for PET.
abstract: The integration of magnetic resonance imaging (MRI) and positron emission tomography (PET) is an upcoming hybrid imaging technique. Prototype scanners for pre-clinical and clinical research have been built and tested. However, the potential of the PET part can be better exploited if the arterial input function (AIF) of the administered tracer is known. This work presents a dedicated MR-compatible blood sampling system for precise measurement of the AIF in an MR-PET study. The device basically consists of an LSO/APD-detector assembly which performs a coincidence measurement of the annihilation photons resulting from positron decays. During the measurement, arterial blood is drawn continuously from an artery and lead through the detector unit. Besides successful tests of the MR compatibility and the detector performance, measurements of the AIF of rats have been carried out. The results show that the developed blood sampling system is a practical and reliable tool for measuring the AIF in MR-PET studies.
authors.affiliation: Max Planck Institute for Neurological Research, Gleueler Strasse 50, 50931 Cologne, Germany. johannes.breuer@siemens.com
authors.forename: J
authors.initials: J
authors.lastname: Breuer
authors.forename: R
authors.initials: R
authors.lastname: Grazioso
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Schmand
authors.forename: K
authors.initials: K
authors.lastname: Wienhard
mesh_terms: D000818:Animals; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D001769:Blood / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D049268:Positron-Emission Tomography / Q000295:instrumentation*; D051381:Rats; D017208:Rats, Wistar; D018511:Systems Integration