Substitution (γ335Trp→Arg) in fibrinogen Fremantle causes diminished γ chain expression and increased sialic acid content.
Brennan
Stephen O
SO
Davis
Ryan L
RL
D000328:Adult; D019943:Amino Acid Substitution; D001120:Arginine; D001777:Blood Coagulation / Q000235:genetics; D025861:Blood Coagulation Disorders, Inherited / Q000097:blood* / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015241:Fibrinogens, Abnormal / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D010375:Pedigree; D010641:Phenotype; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014364:Tryptophan
D015241:Fibrinogens, Abnormal; C556790:fibrinogen Fremantle; C027539:fibrinopeptides gamma; D014364:Tryptophan; D005340:Fibrinogen; D001120:Arginine; D019158:N-Acetylneuraminic Acid