[Influence of the concentration of silver nanoparticles on the proliferation behavior of human umbilical vein endothelial cell and human umbilical artery smooth muscle cells].
The proliferation difference between Human Umbilical Vein Endothelial Cells (HUVEC) and Human Umbilical Artery Smooth Muscle Cells (HUASMC) in response to the concentration of silver nanoparticles was investigated via MTT, BCA and FCM tests. The obtained experimental data were statistically analyzed and discussed in order to know the causation of the proliferation difference. The results show there is significant difference in proliferation between HUVEC and HUASMC corresponding to the concentration of silver nanoparticles, and such difference can be attributed to the varied adhesion shape and apoptosis of the cells being influenced by nano-Ag content and Fetal bovine serum (FBS) content in culture medium.
Shi
Qin
Q
Department of Physics, East China Normal University, Shanghai 200062, China.
Wang
Xianghui
X
Yu
Wenjuan
W
Huang
Rui
R
D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D012834:Silver / Q000494:pharmacology*; D014469:Umbilical Arteries / Q000166:cytology*
D012834:Silver