Familial clustering of type 2 diabetes in Korean women with gestational diabetes mellitus.
OBJECTIVE
This study was conducted to examine the relationship between family history of type 2 diabetes (T2DM) and risk of developing gestational diabetes mellitus (GDM) in Korean women.


METHODS
We performed a 100-g oral glucose tolerance test in 858 pregnant women who had abnormal glucose tolerance in 50-g oral glucose challenge. In addition, we reviewed the incidence of T2DM in the parents and siblings and analyzed the association between the familial history of T2DM and the risk of GDM.


RESULTS
Of the 858 subjects, 427 were normal, and 431 were diagnosed with GDM. Compared with women with no family history of T2DM, women with first degree family history of T2DM displayed higher risk of T2DM (odd ratio: parent only 1.91, sibling only 6.24, any 2.27).


CONCLUSIONS
The risk of developing GDM was significantly increased in Korean women with a family history of T2DM in first-degree relatives.
Rhee
Sang Youl
SY
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
Kim
Joo Young
JY
Woo
Jeong-Taek
JT
Kim
Young Seol
YS
Kim
Sung-Hoon
SH
D000328:Adult; D016000:Cluster Analysis; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D006801:Humans; D007723:Korea; D008297:Male; D010290:Parents; D011247:Pregnancy; D012307:Risk Factors; D035781:Siblings