Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning.
Even if there is clinical evidence that carbon monoxide poisoning determines cardiac damage, the literature on the cardiac pathomorphology in such cases is scarce. We investigated the immunohistochemical expression of two known markers of fresh cardiac damage, fibronectin and the terminal complement complex C5b-9, in both cardiac ventricles in 26 cases of CO intoxication (study group, 15 ♀, 11 ♂, mean age 47 years, mean COHb level 65.9%, min. 51%, max. 85%) compared to a group of 23 cases of hanging (n = 23, 4♀, 19♂, mean age 42 years) as well as to 25 cases of myocardial infarction (n = 25, 13♀, 12♂, mean age 64 years). Fresh cardiac damage was detected with the antibody fibronectin in cases of CO poisoning and was prevalently localised at the right ventricle.
Fracasso
Tony
T
Institute of Legal Medicine, University Hospital Münster, Röntgenstr. 23, 48149, Münster, Germany. Tony.Fracasso@hcuge.ch
Pfeiffer
Heidi
H
Michaud
Katarzyna
K
Köhler
Helga
H
Sauerland
Cristina
C
Schmeling
Andreas
A
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002249:Carbon Monoxide Poisoning / Q000378:metabolism* / Q000473:pathology; D015938:Complement Membrane Attack Complex / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis
D015415:Biomarkers; D015938:Complement Membrane Attack Complex; D005353:Fibronectins