title: A comparison of intravenous sedation with two doses of dexmedetomidine: 0.2 µg/kg/hr Versus 0.4 µg/kg/hr.
abstract: The present study investigated the physiologic and sedative effects between two different continuous infusion doses of dexmedetomidine (DEX). Thirteen subjects were separately sedated with DEX at a continuous infusion dose of 0.2 µg/kg/hr for 25 minutes after a loading dose of 6 µg/kg/hr for 5 minutes (0.2 group) and a continuous infusion dose of 0.4 µg/kg/hr for 25 minutes after a loading dose of 6 µg/kg/hr for 5 minutes (0.4 group). The recovery process was then observed for 60 minutes post infusion. The tidal volume, mean arterial pressure, and heart rate in both groups decreased significantly during infusion, but they were within a clinically acceptable level. A Trieger dot test plot error ratio in the 0.4 group was significantly higher than that in the 0.2 group until 15 minutes post infusion. Sedation appears to be safe at the infusion doses of DEX studied. However, increasing maintenance infusion doses of DEX from 0.2 µg/kg/hr to 0.4 µg/kg/hr delays some recovery parameters.
authors.affiliation: Department of Dental Anesthesiology, Ohu University School of Dentistry, Fukushima, Japan. maromaro@ce.mbn.or.jp
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kawaai
authors.forename: Jun
authors.initials: J
authors.lastname: Satoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Watanabe
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kan
authors.forename: Steven
authors.initials: S
authors.lastname: Ganzberg
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamazaki
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental / Q000379:methods*; D001794:Blood Pressure; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D018709:Statistics, Nonparametric; D013990:Tidal Volume; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine