title: [Design and synthesis of novel PPARgamma agonists].
abstract: OBJECTIVE
  To design and synthesize novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.
  
  
  METHODS
  A series of novel PPARgamma agonists were designed based on the binding character of PPARgamma agonists and the distribution of pharmacophore. The target compounds were synthesized using p-hydroxybenzaldehyde, 1, 2-dibromoethane, phenol, hydantoin and 2-thiohydantoin as materials.
  
  
  RESULTS
  Twelve compounds were synthesized by etherification and Knoevenagle condensation.
  
  
  CONCLUSIONS
  The target compounds were efficiently synthesized under mild condition and the structures of the target compounds were confirmed by 1HNMR and MS.
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Guo
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D015195:Drug Design; D015946:Ethylene Dibromide / Q000737:chemistry; D006827:Hydantoins / Q000737:chemistry; D047495:PPAR gamma / Q000819:agonists*
chemical_list: D001547:Benzaldehydes; D006827:Hydantoins; D047495:PPAR gamma; D015946:Ethylene Dibromide; C011483:4-hydroxybenzaldehyde