title: Safety and efficacy of low-dose esterified estrogens and methyltestosterone, alone or combined, for the treatment of hot flashes in menopausal women: a randomized, double-blind, placebo-controlled study.
abstract: This study evaluated safety and efficacy of esterified estrogens and methyltestosterone administered alone or in combination for the treatment of hot flashes in menopausal women. The 0.30-mg esterified estrogens and 0.30-mg methyltestosterone combination was the lowest effective dose, and our results are consistent with the known safety profile of estrogen and androgen combination products.
authors.affiliation: Case Medical Center, MacDonald Women's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: James
authors.initials: J
authors.lastname: Liu
authors.forename: Adam
authors.initials: A
authors.lastname: Allgood
authors.forename: Leonard R
authors.initials: LR
authors.lastname: Derogatis
authors.forename: Stephen
authors.initials: S
authors.lastname: Swanson
authors.forename: Michael
authors.initials: M
authors.lastname: O'Mahony
authors.forename: Bertrand
authors.initials: B
authors.lastname: Nedoss
authors.forename: Herbert
authors.initials: H
authors.lastname: Soper
authors.forename: Edward
authors.initials: E
authors.lastname: Zbella
authors.forename: Svetlana Vladimirovna
authors.initials: SV
authors.lastname: Prokofieva
authors.forename: Lisa
authors.initials: L
authors.lastname: Zipfel
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Guo
mesh_terms: D045930:Anabolic Agents / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects; D042724:Estrogens, Esterified (USP) / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008593:Menopause / Q000187:drug effects; D008777:Methyltestosterone / Q000008:administration & dosage* / Q000009:adverse effects; D010919:Placebos; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D045930:Anabolic Agents; D004967:Estrogens; D042724:Estrogens, Esterified (USP); D010919:Placebos; D008777:Methyltestosterone