Healing effect of quince seed mucilage on T-2 toxin-induced dermal toxicity in rabbit.
This study was performed to examine the healing effects of creams prepared from quince seed mucilage on dermal toxicity induced by T-2 toxin. Creams were prepared from quince seed mucilage in eucerin base as 5, 10, and 15% (w/w). To induce dermal toxicity, 100 μg T-2 toxin was dissolved in 12 μl methanol and applied on the shaved skin of rabbit for 2 consecutive days. A separate group received only solvent (methanol). On the third day, the prepared creams were applied on the skin lesions twice a day until complete healing was occurred. Healing, was defined by decreased wound margin, treatment erythema and blisters. Time required for healing was 14, 14, 12, 10, and 9 days for groups of no treatment, eucerin, quince seed cream 5%, 10%, and 15%, respectively. Results obtained by this study shows that quince seed mucilage (15%) has more and better healing effects on dermal toxicity caused by T-2 toxin comparing to no treatment or eucerin cream without mucilage.
Hemmati
Ali Asghar
AA
Dept. of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Kalantari
Hibatoallah
H
Jalali
Amir
A
Rezai
Somie
S
Zadeh
Hossein Haghighi
HH
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D008297:Male; D008517:Phytotherapy / Q000379:methods*; D011817:Rabbits; D027824:Rosaceae; D012639:Seeds; D012871:Skin Diseases / Q000139:chemically induced / Q000188:drug therapy*; D013605:T-2 Toxin / Q000633:toxicity*
D013605:T-2 Toxin