title: [Effects of Valeriana amurensis on the expressions of iNOS, COX-2 and IkappaCB-alpha in Alzheimer's disease model rat's brain].
abstract: OBJECTIVE
  To investigate effects of Valeriana amurensis Smir. ex Kom. on the inflammation reaction of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain.
  
  
  METHODS
  The model of Alzheimer's disease was established with multiple factors and the expressions of iNOS, COX-2, IkappaB-alpha of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rats' brain were observed by electron lens using immunohistochemistry method.
  
  
  RESULTS
  The extracts of Valeriana amurensis could reduce the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin in a dose-dependent manner. The effects of 50% ethanol extracts of macroporous resin group were more significant than other groups.
  
  
  CONCLUSIONS
  The 50% ethanol extract of macroporous resin group from Valeriana amurensis can improve the ability of spatial exploratory and effectively control the inflammation reaction, the mechanism maybe relevant to it's effect of decreasing the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin to inhibit the activity of glia cell and inflammatory injury of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain.
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Zuo
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Xiao
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D020672:I-kappa B Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D010446:Peptide Fragments; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014632:Valerian / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D020672:I-kappa B Proteins; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat