[Evaluation of matrix metalloproteinases (pro-MMP-1, MMP-2,8) and their inhibitor (TIMP-1) contents in patients with occupational lung diseases].
Studies of matrix metalloproteinases in patients with occupational bronchopulmonary diseases and in individuals exposed to asbestos dust revealed hyperactivated protease system--lower level of MMP-1 proenzyme and increased production of TIMP-1 (metalloproteinases inhibitor)--in all the examinees groups. Patients with pneumoconiosis and occupational dust bronchitis demonstrated increased neutrophilic elastase that is activator of metalloproteinases inducing sclerotic changes and pulmonary fibrosis.
Fomina
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Kuz'mina
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D001194:Asbestos / Q000633:toxicity; D001249:Asthma / Q000201:enzymology / Q000209:etiology; D015415:Biomarkers / Q000378:metabolism; D001982:Bronchial Diseases / Q000201:enzymology* / Q000209:etiology; D001991:Bronchitis / Q000201:enzymology / Q000209:etiology; D004391:Dust; D004785:Environmental Pollutants / Q000633:toxicity; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000201:enzymology* / Q000209:etiology; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism*; D009784:Occupational Diseases / Q000201:enzymology* / Q000209:etiology; D011009:Pneumoconiosis / Q000201:enzymology / Q000209:etiology; D011498:Protein Precursors / Q000378:metabolism*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*
D015415:Biomarkers; D004391:Dust; D004785:Environmental Pollutants; D011498:Protein Precursors; D019715:Tissue Inhibitor of Metalloproteinase-1; D001194:Asbestos; D020778:Matrix Metalloproteinase 2; D020784:Matrix Metalloproteinase 8; D020781:Matrix Metalloproteinase 1