title: A propensity score-adjusted retrospective comparison of early and mid-term results of mitral valve repair versus replacement in octogenarians.
abstract: OBJECTIVE
  Feasibility and efficacy of mitral repair in the elderly remain controversial. This study aims to compare outcomes of mitral repair and replacement in octogenarians.
  
  
  RESULTS
  We compared the outcomes of 322 consecutive octogenarian patients (mean age 82.6 ± 2.2 years) who underwent mitral repair (n = 227, 70%) or replacement (n = 95, 30%) at Mount Sinai Medical Center and Leipzig Herzzentrum between 1998 and 2008 using propensity score adjustment and univariate and multivariate analyses. Patients undergoing aortic valve replacement were excluded. Coronary bypass was performed in 47.5% (n = 153), and 31.1% (n = 100) required tricuspid repair. Propensity score adjustment yielded comparable groups. Thirty-day mortality in patients undergoing primary elective mitral repair for degenerative disease was 5.1% (2/39). Overall 90-day mortality was 18.9% (43/227) for repair compared with 31.6% (30/95) for replacement (P = 0.014). Pre-discharge echocardiography revealed less than moderate residual regurgitation in 99% of patients (231/232). Adjusted 1-, 3-, and 5-year survival for patients undergoing mitral repair was 71 ± 3, 61 ± 4, and 59 ± 4%, respectively, compared with 56 ± 5, 50 ± 6, and 45 ± 6% for patients undergoing mitral replacement (P = 0.046). Multivariate analysis demonstrated emergency surgery, previous myocardial infarction, concomitant coronary artery bypass surgery, and mitral replacement to be strong independent predictors of early mortality; mitral valve replacement was an independent predictor of reduced survival in degenerative patients.
  
  
  CONCLUSIONS
  Elective mitral repair can be performed with low operative mortality and good long-term outcomes in selected octogenarians with degenerative mitral disease, and is associated with better long-term survival than mitral replacement. The survival benefit associated with surgery for non-degenerative disease is more questionable.
authors.affiliation: Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Chikwe
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Goldstone
authors.forename: Jurgen
authors.initials: J
authors.lastname: Passage
authors.forename: Anelechi C
authors.initials: AC
authors.lastname: Anyanwu
authors.forename: Joerg
authors.initials: J
authors.lastname: Seeburger
authors.forename: Javier G
authors.initials: JG
authors.lastname: Castillo
authors.forename: Farzan
authors.initials: F
authors.lastname: Filsoufi
authors.forename: Friedrich W
authors.initials: FW
authors.lastname: Mohr
authors.forename: David H
authors.initials: DH
authors.lastname: Adams
mesh_terms: D000369:Aged, 80 and over; D001026:Coronary Artery Bypass / Q000401:mortality / Q000706:statistics & numerical data; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D058386:Mitral Valve Annuloplasty / Q000379:methods* / Q000401:mortality; D008944:Mitral Valve Insufficiency / Q000401:mortality / Q000601:surgery*; D057216:Propensity Score; D012189:Retrospective Studies; D016896:Treatment Outcome