title: Enough is enough! Patients who do not conceive on 600 IU/d of gonadotropins show no improvement from an additional 150 IU of LH activity.
abstract: Studies have suggested that supplemental LH improves outcomes in assisted reproductive technology (ART) cycles. In this retrospective review, an additional 150 IU of LH activity did not improve ART outcomes in women undergoing a second round of IVF/ intracytoplasmic sperm injection (ICSI) after an initial failed cycle using 600 IU of gonadotropins.
authors.affiliation: Program in Reproductive Endocrinology and Infertility, National Institutes of Health, Walter Reed Army Medical Center, National Naval Medical Center, and Uniformed Services University of the Health Sciences, Bethesda, Maryland 20892, USA. maguiremf@mail.nih.gov
authors.forename: Marcy
authors.initials: M
authors.lastname: Maguire
authors.forename: John
authors.initials: J
authors.lastname: Csokmay
authors.forename: James
authors.initials: J
authors.lastname: Segars
authors.forename: Mark
authors.initials: M
authors.lastname: Payson
authors.forename: Alicia
authors.initials: A
authors.lastname: Armstrong
mesh_terms: D000022:Abortion, Spontaneous; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D016729:Leuprolide / Q000008:administration & dosage*; D007986:Luteinizing Hormone / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D005300:Fertility Agents, Female; D011994:Recombinant Proteins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide