Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities.
OBJECTIVE
This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH).


METHODS
The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms.


RESULTS
Seventy-seven stroke patients (mean WMH volume: 39.5 cm(3)) were recruited. Thirty patients (39%) had ≥ 1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression.


CONCLUSIONS
Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.
Mok
Vincent C T
VC
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, China. vctmok@cuhk.edu.hk
Wong
Adrian
A
Wong
Kelvin
K
Chu
Winnie C W
WC
Xiong
Yunyun
Y
Chan
Anne Y Y
AY
Kwok
Timothy C Y
TC
Hu
Xintao
X
Lee
W K
WK
Tang
Wai-kwong
WK
Wong
Ka-sing Lawrence
KS
Wong
Stephen
S
D000368:Aged; D001284:Atrophy; D002545:Brain Ischemia / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000523:psychology; D003863:Depression / Q000503:physiopathology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D056784:Leukoencephalopathies / Q000473:pathology* / Q000523:psychology*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications / Q000473:pathology* / Q000523:psychology*