Influence of attention focus on neural activity in the human spinal cord during thermal sensory stimulation.
Perceptions of sensation and pain in healthy people are believed to be the net result of sensory input and descending modulation from brainstem and cortical regions depending on emotional and cognitive factors. Here, the influence of attention on neural activity in the spinal cord during thermal sensory stimulation of the hand was investigated with functional magnetic resonance imaging by systematically varying the participants' attention focus across and within repeated studies. Attention states included (1) attention to the stimulus by rating the sensation and (2) attention away from the stimulus by performing various mental tasks of watching a movie and identifying characters, detecting the direction of coherently moving dots within a randomly moving visual field and answering mentally-challenging questions. Functional MRI results spanning the cervical spinal cord and brainstem consistently demonstrated that the attention state had a significant influence on the activity detected in the cervical spinal cord, as well as in brainstem regions involved with the descending analgesia system. These findings have important implications for the detection and study of pain, and improved characterization of the effects of injury or disease.
Stroman
Patrick W
PW
Department of Diagnostic Radiology, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada K7L 2V7. stromanp@post.queensu.ca
Coe
Brian C
BC
Munoz
Doug P
DP
D000328:Adult; D001288:Attention / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003463:Cues; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009474:Neurons / Q000502:physiology*; D010812:Physical Stimulation / Q000379:methods; D013116:Spinal Cord / Q000502:physiology*; D013647:Task Performance and Analysis; D013697:Thermosensing / Q000502:physiology*