title: Formulation of water-dispersible nanopermethrin for larvicidal applications.
abstract: The formulation of water dispersible nanopermethrin was investigated for its larvicidal property. Nanopermethrin was prepared using solvent evaporation of oil in water microemulsion, which was obtained by mixing an organic and aqueous phase. The mean particle size of nanodispersion in water was 151 ± 27 nm. X-ray diffraction (XRD) of nanopermethrin showed it was amorphous. Larvicidal studies were carried out against Culex quinquefasciatus and the results were compared with bulk permethrin. The LC(50) of nanopermethrin to Cx. quinquefasciatus was 0.117 mg/L. The LC(50) of bulk permethrin to Cx. quinquefasciatus was 0.715 mg/L. Nanopermethrin may be a good choice as a potent and selective larvicide for Cx. quinquefasciatus.
authors.affiliation: Nanobio-medicine Research Group, School of Bio Sciences & Technology, VIT University, Vellore, India.
authors.forename: C H
authors.initials: CH
authors.lastname: Anjali
authors.forename: S
authors.initials: S
authors.lastname: Sudheer Khan
authors.forename: Katrin
authors.initials: K
authors.lastname: Margulis-Goshen
authors.forename: Shlomo
authors.initials: S
authors.lastname: Magdassi
authors.forename: Amitava
authors.initials: A
authors.lastname: Mukherjee
authors.forename: N
authors.initials: N
authors.lastname: Chandrasekaran
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003465:Culex / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D004655:Emulsions / Q000737:chemistry / Q000494:pharmacology; D007306:Insecticides / Q000494:pharmacology*; D007928:Lethal Dose 50; D049329:Nanostructures / Q000737:chemistry*; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D026023:Permethrin / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D004655:Emulsions; D007306:Insecticides; D009821:Oils; D012997:Solvents; D014867:Water; D026023:Permethrin