title: [Epstein-Barr virus and cytomegalovirus primary infections: a comparative study in 52 immunocompetent adults].
abstract: OBJECTIVE
  The objective of this study was to compare epidemiological, clinical, and biological data of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) primary infections in immunocompetent adults, admitted in the infectious disease department of the Reims Teaching Hospital between 2000 and 2005.
  
  
  METHODS
  Inclusion criteria were the presence of anti-VCA IgM antibodies or the presence of CMV specific IgM antibodies and the absence of any other positive serology. Differences in reported percentage were compared with a Khi(2) test or Fischer's exact test, when appropriate. Continuous variables were compared with the Mann-Whitney Test.
  
  
  RESULTS
  There were no significant changes over the years in the numbers of EBV (n=32) and CMV (n=20) primary infections. The patient's mean age was 22.7 years (14-48 years) in EBV primary infections and 38.6 years (13-66 years) in CMV primary infections (P<0.01). The clinical variables significantly associated with primary EBV infection were sore throat and cervical lymphadenopathy (P<0.01). Arthromyalgia and respiratory manifestations were less frequent in EBV primary infection (P<0.01). The biological variables significantly associated with EBV primary infection were a marked alanine aminotransferase elevation and a marked lymphocytosis with atypical lymphocytes (P<0.001). Thrombopenia was less frequently associated with EBV primary infection (P<0.001).
  
  
  CONCLUSIONS
  Clinical and biological presentations of EBV and CMV primary infections were similar. The simultaneous serologic diagnosis of these two infections remains necessary to provide a specific diagnosis, for the most efficient patient care.
authors.affiliation: Service de médecine interne et des maladies infectieuses, hôpital Robert-Debré, avenue du Général-Koenig, Reims cedex, France.
authors.forename: A-S
authors.initials: AS
authors.lastname: Batalla
authors.forename: D
authors.initials: D
authors.lastname: Benito
authors.forename: S
authors.initials: S
authors.lastname: Baumard
authors.forename: V
authors.initials: V
authors.lastname: Brodard
authors.forename: A
authors.initials: A
authors.lastname: Servettaz
authors.forename: R
authors.initials: R
authors.lastname: Jaussaud
authors.forename: C
authors.initials: C
authors.lastname: Strady
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D005602:France / Q000453:epidemiology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007121:Immunocompetence; D008206:Lymphatic Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010612:Pharyngitis / Q000209:etiology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D000410:Alanine Transaminase