title: Acute HIV-1 infection: what's new? Where are we going?
abstract: This supplemental issue of the Journal of Infectious Diseases is devoted to the important topic of primary human immunodeficiency virus type 1 (HIV-1) infection. It was prompted by the planning of the Acute HIV-1 Infection Meeting in Boston in September 2009, at which leading scientists and practitioners gathered to discuss new insights into the early, critical events of HIV-1 infection. The reviews that follow underline the current state of the field with regard to transmission biology of HIV-1; the clinical presentation, diagnosis, and management of primary HIV-1 infection; the pathogenesis of primary HIV-1 infection; and innate and adaptive immune responses to the virus. We trust that these findings have the potential to influence the development of effective vaccine strategies.
authors.affiliation: Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: M Patricia
authors.initials: MP
authors.lastname: D'Souza
authors.forename: Karen L
authors.initials: KL
authors.lastname: Axten
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Hecht
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D035843:Biomedical Research / Q000639:trends; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D015497:HIV-1 / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity*; D006801:Humans
chemical_list: D016915:AIDS Vaccines