title: Is there a role for microRNAs in exercise immunology? A synopsis of current literature and future developments.
abstract: With the discovery of microRNAs (miRNAs), an exceptional means of regulating gene expression was introduced a few years ago. MiRNAs function to inactivate specific messenger RNA transcripts leading to depletion of the corresponding protein, whereby computational studies have shown that about one third of all animal genes might be miRNA targets. Recent publications highlight the involvement of miRNAs in regulating the immune response. The aim of this review is to provide an overview of miRNA biogenesis and function, to illustrate their impact on both the innate as well as the adaptive immune system, to show the regulation of skeletal muscle plasticity and inflammation, and finally to present their possible role within the field of exercise immunology.
authors.affiliation: Centre for Sports Sciences and University Sports, Department of Sports and Exercise Physiology, University of Vienna, Vienna, Austria. barbara.wessner@univie.ac.at
authors.forename: Barbara
authors.initials: B
authors.lastname: Wessner
authors.forename: Laura
authors.initials: L
authors.lastname: Gryadunov-Masutti
authors.forename: Harald
authors.initials: H
authors.lastname: Tschan
authors.forename: Norbert
authors.initials: N
authors.lastname: Bachl
authors.forename: Erich
authors.initials: E
authors.lastname: Roth
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D055633:Immune System Phenomena / Q000235:genetics*; D035683:MicroRNAs / Q000276:immunology*
chemical_list: D035683:MicroRNAs