title: In vitro comparison of self versus professionally applied remineralizing materials.
abstract: OBJECTIVE
  To compare the effect of 4 remineralizing materials on the incipient artificial carious lesion and its proximal sound enamel when used with fluoride dentifrice.
  
  
  METHODS
  Models mimicking proximal contact were made, each of which was placed with an artificial carious specimen in contact with a sound enamel specimen. Each carious specimen was treated with one of four materials: glass ionomer cement (GIC), resin modified glass ionomer cement (RMGIC), 5000 ppm sodium fluoride (F-gel), and casein phosphopeptide amorphous calcium phosphate (CPP-ACP). The GIC and RMGIC specimens were thermocycled. Then all specimens were pH-cycled for 5 days with twice a day soaking in 1,000 ppm NaF dentifrice solution. Specimens were examined by polarized light microscopy and lesion area quantified by image analysis.
  
  
  RESULTS
  RMGIC significantly yielded smaller areas of lesion than CPP-ACP and GIC (p < 0.05). F-gel reduced more area of lesion than CPP-ACP significantly (p < 0.05). In the associated contact, RMGIC significantly reduced the area of lesion better than CPP-ACP (p < 0.05).
  
  
  CONCLUSIONS
  The most effective remineralizing material in reducing the carious lesion areas was RMGIC followed by F-gel, GIC and CPP-ACR The demineralization inhibitory effects on the associated sound contact enamel followed the same trend.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, 34 Henri Dunant Road, Pathumwan, Bangkok 10330,Thailand. ctrairat@yahoo.com
authors.forename: Chutima
authors.initials: C
authors.lastname: Trairatvorakul
authors.forename: Napassorn
authors.initials: N
authors.lastname: Kangvansurakit
authors.forename: Jarinya
authors.initials: J
authors.lastname: Pathomburi
mesh_terms: D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002364:Caseins / Q000627:therapeutic use; D003731:Dental Caries / Q000503:physiopathology* / Q000517:prevention & control; D003743:Dental Enamel / Q000187:drug effects*; D003764:Dental Materials / Q000627:therapeutic use*; D003802:Dentifrices / Q000008:administration & dosage / Q000627:therapeutic use; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005899:Glass Ionomer Cements / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007091:Image Processing, Computer-Assisted; D008422:Materials Testing; D008859:Microscopy, Polarization; D019279:Resin Cements / Q000627:therapeutic use; D012464:Saliva, Artificial / Q000737:chemistry; D012969:Sodium Fluoride / Q000627:therapeutic use; D013696:Temperature; D013997:Time Factors; D014089:Tooth Remineralization / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; D003764:Dental Materials; D003802:Dentifrices; C493186:Fuji VII; D005899:Glass Ionomer Cements; C090340:Reliance resin cement; D019279:Resin Cements; D012464:Saliva, Artificial; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D014867:Water; D012969:Sodium Fluoride; D005459:Fluorides