Incidence of influenza virus infection in early infancy: a prospective study in South Asia.
We evaluated infant sera from an immunization trial in Bangladesh to assess influenza hemagglutination inhibition antibody titer increases in 131 unimmunized infants from birth to 6 months. We detected 31 serologically defined infections. Combined with 10 additional rapid test-proven influenza cases, the minimal estimated incidence was 31 of 100 infants (95% CI: 24-41). These data suggest a high burden of influenza in young infants in tropical South Asia.
Henkle
Emily
E
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Steinhoff
Mark C
MC
Omer
Saad B
SB
Roy
Eliza
E
Arifeen
Shams E
SE
Raqib
Rubhana
R
McNeal
Monica
M
Breiman
Robert F
RF
Moss
William J
WJ
Zaman
K
K
D000914:Antibodies, Viral / Q000097:blood*; D001208:Asia / Q000453:epidemiology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000453:epidemiology*; D008297:Male; D011446:Prospective Studies; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral