False bisalbuminemia and hyperalphafetoproteinemia.
The capillary electrophoresis is a very powerful separation method offering a high degree of resolution. However, certain interferences can be detected giving transitory shoulders or peaks. We report the case of a serum protein electrophoresis performed with Capillarys (Sebia) in a 68-year-old patient, hospitalized for cancer of the head of the pancreas, which showed an important shoulder in the migratory range of albumin, simulating bisalbuminemia. An interference with alphafetoprotein was proven explaining this electrophoretic aspect.
Boujelbene
A
A
Laboratoire de biochimie et de toxicologie, hôpital universitaire de Monastir, 5000 Monastir, Tunisia.
Hellara
I
I
Neffati
F
F
Najjar
M F
MF
D000368:Aged; D000418:Albumins / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood; D019075:Electrophoresis, Capillary / Q000379:methods; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000418:Albumins; D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins; C030764:bisalbumins