Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines.
Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing α-aminopyrazines with α-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.
Myadaraboina
Shailaja
S
Organic Chemistry Division-II, Indian Institute of Chemical Technology, Tarnaka-uppal road, Tarnaka, Hyderabad 500607, India.
Alla
Manjula
M
Saddanapu
Venkateshwarlu
V
Bommena
Vittal Rao
VR
Addlagatta
Anthony
A
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007093:Imidazoles; D011719:Pyrazines