title: Association of serum adipocytokines with hepatic steatosis and fibrosis in patients with chronic hepatitis C.
abstract: BACKGROUND
  The pathogenic mechanisms of hepatic steatosis in hepatitis C (HCV) remain unclear.
  
  
  OBJECTIVE
  To assess the potential role of cytokines and adipokines in HCV-related steatosis and fibrosis.
  
  
  METHODS
  We profiled several adipokines, cytokines, and related soluble molecules in 99 HCV patients and analyzed their potential associations with hepatic steatosis and fibrosis.
  
  
  RESULTS
  Serum leptin and IL-1RA were significantly higher in HCV genotype 1 as compared to genotype 3. On the other hand, serum resistin, IL-8, IL-1B and sIL-6R, were significantly higher in HCV genotype 3. No differences were observed for adiponectin, visfatin, IL-6 and TNF-α. Regardless of HCV genotype, steatosis could be predicted by a combination of IL-8, IL-6, and sIL-6R/IL-6. When analysis was repeated for each of the genotypes, the reliability of models improved. Regardless of HCV genotype, moderate to severe fibrosis (Metavir score >F2), was predicted by IL-8 and resistin levels.
  
  
  CONCLUSIONS
  Analysis of adipocytokines associated with steatosis supports the hypothesis that steatogenic pathways differ in HCV genotype 3 from those infected with non-genotype 3 infections.
authors.affiliation: Translational Research Institute, Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Va. 22042, USA.
authors.forename: Ancha
authors.initials: A
authors.lastname: Baranova
authors.forename: Mohammed H
authors.initials: MH
authors.lastname: Jarrar
authors.forename: Maria
authors.initials: M
authors.lastname: Stepanova
authors.forename: Andrew
authors.initials: A
authors.lastname: Johnson
authors.forename: Nila
authors.initials: N
authors.lastname: Rafiq
authors.forename: Terry
authors.initials: T
authors.lastname: Gramlich
authors.forename: Vikas
authors.initials: V
authors.lastname: Chandhoke
authors.forename: Zobair M
authors.initials: ZM
authors.lastname: Younossi
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D016207:Cytokines / Q000097:blood*; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism / Q000821:virology*; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000378:metabolism / Q000821:virology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism / Q000821:virology*; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis
chemical_list: D054392:Adipokines; D016207:Cytokines