title: Modelling cement augmentation: a comparative experimental and finite element study at the continuum level.
abstract: Subject-specific computational models of anatomical components can now be generated from image data and used in the assessment of orthopaedic interventions. However, little work has been undertaken to model cement-augmented bone using these methods. The purpose of this study was to investigate different methods of representing a trabecular-like material (open-cell polyurethane foam, Sawbone, Sweden) augmented with poly(methyl methacrylate) (PMMA) bone cement in a finite element (FE) model. Three sets of specimens (untreated, fully augmented with cement, partially augmented with cement) were imaged using micro computed tomography (microCT) and tested under axial compression. Subject-specific continuum level FE models were built based on the microCT images. Using the first two sets of models, the material conversion factors between image greyscale and mechanical properties for the pure synthetic bone and cement-augmented composite were determined iteratively by matching the FE predictions to the experimental measurements. By applying these greyscale related mechanical properties to the FE models of the partially augmented specimens, the predicted stiffness was found to be more accurate (approximately 5 per cent error) than using homogeneous properties for the augmented and synthetic bone regions (approximately 18 per cent error). It was also found that the predicted stiffness using the modulus of pure cement to define the augmented region was overestimated, and generally the apparent elastic modulus was dominated by the properties of the synthetic bone.
authors.affiliation: Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK. meyz@leeds.ac.uk
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: Z M
authors.initials: ZM
authors.lastname: Jin
authors.forename: R K
authors.initials: RK
authors.lastname: Wilcox
mesh_terms: D001696:Biomechanical Phenomena; D001843:Bone Cements; D018786:Bone Substitutes; D019245:Compressive Strength; D003198:Computer Simulation; D055119:Elastic Modulus; D020342:Finite Element Analysis; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008954:Models, Biological; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes