title: Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy.
abstract: BACKGROUND
  It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC.
  
  
  METHODS
  Using population-based data, we calculated BC risk following HL according to clinicopathologic features.
  
  
  RESULTS
  Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC.
  
  
  CONCLUSIONS
  Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors.
authors.affiliation: Medical Service, Department of Veterans Affairs Medical Center, 921 N.E. 13th Street, Oklahoma City, OK 73104, USA. doresg@mail.nih.gov
authors.forename: G M
authors.initials: GM
authors.lastname: Dores
authors.forename: W F
authors.initials: WF
authors.lastname: Anderson
authors.forename: L E
authors.initials: LE
authors.lastname: Beane Freeman
authors.forename: J F
authors.initials: JF
authors.lastname: Fraumeni
authors.forename: R E
authors.initials: RE
authors.lastname: Curtis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors; D018426:SEER Program; D017741:Survivors