title: Oleanane-type triterpene glucuronides from the roots of Glycyrrhiza uralensis Fischer.
abstract: Investigation of characteristic constituents of the roots of Glycyrrhiza uralensis Fischer led to isolation of four new triterpene glucuronides, namely uralsaponins C-F (1-4), an artificial product, namely the methyl ester of glycyrrhizin (5), as well as six known triterpene glucuronides (6-11). These new compounds were identified by 1D and 2D NMR spectroscopic analysis. The cytotoxicity of the selected compounds and their aglycones were evaluated against HeLa and MCF-7 cancer cell lines, and the preliminary structure-activity relationship was also elucidated.
authors.affiliation: Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing, China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zheng
authors.forename: Lian-Wen
authors.initials: LW
authors.lastname: Qi
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Cui
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Peng
authors.forename: Yong-Bo
authors.initials: YB
authors.lastname: Peng
authors.forename: Mei-Ting
authors.initials: MT
authors.lastname: Ren
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Cheng
authors.forename: Ping
authors.initials: P
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D006035:Glycyrrhiza / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D019695:Glycyrrhizic Acid