title: Risk factors related to hypertension among patients in a cohort living with HIV/AIDS.
abstract: BACKGROUND
  Studies disagree as to whether there is a greater prevalence of hypertension among HIV/AIDS patients and the role of antiretroviral therapy.
  
  
  OBJECTIVE
  Evaluate the prevalence of hypertension and risk factors in a cohort of HIV-infected patients, with emphasis on antiretroviral therapy.
  
  
  METHODS
  Case-control study conducted at baseline of a cohort, between June/2007 and December/2008 in Pernambuco/Brazil. Blood pressure was classified as normal, prehypertension, and hypertension.
  
  
  RESULTS
  Of 958 patients, 245 (25.6%) had hypertension (cases), 325 (33.9%) had prehypertension, and 388 (40.5%) were normotensive (controls). Comparison between hypertensive and normotensive patients showed that traditional factors, such as age > 40 (OR = 3.06, CI = 1.91-4.97), male gender (OR = 1.85, CI = 1.15-3.01), BMI > 25 (OR = 5.51, CI = 3.36-9.17), and triglycerides > 150 mg/dL (OR = 1.69, CI = 1.05-2.71), were independently associated with hypertension. Duration of antiretroviral therapy and CD4 > 200 cells/mm³ were associated with hypertension in univariate analysis, but did not remain in final model. Type of antiretroviral schema and lipodystrophy showed no association with hypertension.
  
  
  CONCLUSIONS
  Hypertension in HIV/AIDS patients is partially linked to invariable factors, such as age and sex. Efforts should be directed toward controlling reversible factors, particularly excessive weight gain and unsuitable diet.
authors.affiliation: Universidade Federal da Paraiba, Brazil. evanizio@cardiol.br
authors.forename: Evanizio Roque de
authors.initials: ER
authors.lastname: Arruda Junior
authors.forename: Heloisa Ramos
authors.initials: HR
authors.lastname: Lacerda
authors.forename: Libia Cristina Rocha Vilela
authors.initials: LC
authors.lastname: Moura
authors.forename: Maria de Fatima Pessoa Militão de
authors.initials: Mde F
authors.lastname: Albuquerque
authors.forename: Democrito de Barros
authors.initials: Dde B
authors.lastname: Miranda Filho
authors.forename: George Tadeu Nunes
authors.initials: GT
authors.lastname: Diniz
authors.forename: Valeria Maria Gonçalves de
authors.initials: VM
authors.lastname: Albuquerque
authors.forename: Josefina Cláudia Zirpoli
authors.initials: JC
authors.lastname: Amaral
authors.forename: Ricardo Alencar de Arraes
authors.initials: RA
authors.lastname: Ximenes
authors.forename: Verônica Soares
authors.initials: VS
authors.lastname: Monteiro
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D004812:Epidemiologic Methods; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008019:Life Style; D008297:Male; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents