title: [Locally recurrent rectal cancer].
abstract: Over the last decades the therapy of rectal carcinoma has shown continuous improvement. Due to improvements in operative techniques, such as the establishment of total mesorectal excision (TME) and the combination of surgery and (neo-) adjuvant radiochemotherapy, the incidence of locally recurrent rectal cancer could be improved from nearly 50% to less then 10%. Nevertheless recurrent rectal carcinoma remains a severe problem. Predictive factors relating to locally recurrent rectal cancer are surgical experience, localization of the tumor, circumferential resection margins, stage-oriented multimodal therapy and a suitable oncological procedure for the primary tumor. In addition the tumor-specific biology also seems to be a relevant risk factor for recurrence. Operative treatment of locally recurrent rectal cancer was seen for a long time as a palliative procedure. Newer data show that resection of locally recurrent rectal cancer can be carried out with a curative intention in experienced institutions with a long-term 5 year survival of about 30% and mortality around 5%. The composite sacropelvic resection technique is a reasonable option in the curative treatment of locally recurrent rectal cancer. For the future the focus must be on improvements in the primary therapy of rectal carcinoma to avoid local recurrence. In addition early diagnosis of local recurrence and multimodal therapies will be of decisive importance.
authors.affiliation: Klinik für Allgemein- und Viszeralchirurgie, Klinikum Oldenburg GmbH, Rahel-Straus-Straße 10, 26133, Oldenburg, Deutschland. achimtroja@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Troja
authors.forename: H R
authors.initials: HR
authors.lastname: Raab
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D007432:Intraoperative Period; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D009367:Neoplasm Staging; D010166:Palliative Care; D010385:Pelvic Exenteration / Q000009:adverse effects / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012007:Rectum / Q000601:surgery; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome