Molecular epidemiology of PRRSV: a phylogenetic perspective.
Since its first discovery two decades ago, porcine reproductive and respiratory syndrome virus (PRRSV) has been the subject of intensive research due to its huge impact on the worldwide swine industry. Thanks to the phylogenetic analyses, much has been learned concerning the genetic diversity and evolution history of the virus. In this review, we focused on the evolutionary and epidemiological aspects of PRRSV from a phylogenetic perspective. We first described the diversity and transmission dynamics of Type 1 and 2 PRRSV, respectively. Then, we focused on the more ancient evolutionary history of PRRSV: the time of onset of all existing PRRSV and an origin hypothesis were discussed. Finally, we summarized the results from previous recombination studies to assess the potential impact of recombination on the virus epidemiology.
Shi
Mang
M
School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
Lam
Tommy Tsan-Yuk
TT
Hon
Chung-Chau
CC
Hui
Raymond Kin-Hei
RK
Faaberg
Kay S
KS
Wennblom
Trevor
T
Murtaugh
Michael P
MP
Stadejek
Tomasz
T
Leung
Frederick Chi-Ching
FC
D000818:Animals; D016000:Cluster Analysis; D019143:Evolution, Molecular; D014644:Genetic Variation; D017720:Molecular Epidemiology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D013552:Swine
D012367:RNA, Viral