Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome.
OBJECTIVE
To investigate the differences in depressive mood and quality of life in patients with between functional dyspepsia (FD), irritable bowel syndrome (IBS), and FD-IBS overlap as diagnosed based on Rome III criteria.


METHODS
The subjects completed a questionnaire based on Rome III criteria, the Beck Depressive Inventory (BDI) including Cognitive Depression Index (CDI) for depressive mood evaluation and the 36-item Short Form general health survey (SF-36) for quality of life assessment. Upper gastrointestinal endoscopy and colonoscopy were performed to exclude organic disease.


RESULTS
Of 279 subjects, 70 and 124 subjects were diagnosed as FD and IBS, respectively. FD-IBS overlap patients (n=42) and FD alone patients (n=28) showed higher BDI scores than normal subjects (n=127) (P<.001 and P=.02, respectively), whereas that of IBS alone patients (n=82) did not show difference (P=.17). All the SF-36 subscores of the FD-IBS overlap patients were significantly lower than normal subjects (P<.05).


CONCLUSIONS
Depressive mood was significantly related to FD and FD-IBS overlap but not to IBS based on Rome III criteria. FD-IBS overlap patients have worse quality of life than FD-alone and IBS-alone patients.
Lee
Heon-Jeong
HJ
Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
Lee
Sun-Young
SY
Kim
Jeong Hwan
JH
Sung
In-Kyung
IK
Park
Hyung Seok
HS
Jin
Choon Jo
CJ
Kang
Seung-Gul
SG
Yoon
Hiejin
H
Chun
Hoon Jai
HJ
D000328:Adult; D015897:Comorbidity; D003866:Depressive Disorder / Q000523:psychology*; D004415:Dyspepsia / Q000523:psychology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000523:psychology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires