[Influenza A/H1N1v 2009 during pregnancy and breastfeeding: which antiviral to choose?].
Pregnant women are at increased risk of severe complications associated with H1N1 pandemic influenza. Fever and inflammatory syndrome associated with the infection may also be deleterious for the developing fetus. Therefore, early antiviral treatment is recommended. Oseltamivir and zanamivir are the two therapeutic options available indicated in the treatment of H1N1 influenza; however, limited data is published on their use during pregnancy and lactation. In this review, we will focus on the effects of H1N1 during pregnancy and on data safety of antivirals during pregnancy and lactation. Main health authorities recommendations for H1N1 influenza treatment of pregnant women will also be presented.
Skalli
S
S
Unité de Recherche en Pratique Pharmaceutique, Département de Pharmacie, Centre Hospitalier Universitaire Sainte-Justine, 3175 chemin de la Côte-Sainte-Catherine, Montréal H3T 1C5, Canada.
Ferreira
E
E
Bussières
J-F
JF
Allenet
B
B
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001942:Breast Feeding; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines / Q000009:adverse effects / Q000627:therapeutic use; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control; D053139:Oseltamivir / Q000627:therapeutic use; D011247:Pregnancy; D053243:Zanamivir / Q000627:therapeutic use
D000998:Antiviral Agents; D007252:Influenza Vaccines; D053139:Oseltamivir; D053243:Zanamivir