Coarse-grained simulations of stretching entangled DNA using oscillating electric fields.
DNA stretching in entangling media with oscillating electric fields is useful in DNA sequencing. We propose that stretching occurs around hairpin loops at the chain ends, caused by interactions with the medium. Brownian dynamics simulations show that this mechanism explains several experimental observations, including a resonance with varying field frequency.
Graham
Richard S
RS
School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK. Richard.Graham@nottingham.ac.uk
Larson
Ronald G
RG
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004574:Electromagnetic Fields; D056004:Molecular Dynamics Simulation
D004247:DNA