Clinical cancer genetics: Part I: Gastrointestinal.
There is an increasing recognition of the importance of genetic and familial cancer syndromes in routine clinical practice. Although most of gastrointestinal cancers are sporadic, a number of important cancer predisposition syndromes are now recognized and well characterized. In this review, we discuss some of the basic principles of clinical cancer genetics and clinically relevant aspects of the more common gastrointestinal cancer syndromes from the perspective of practicing radiation oncologists.
Pollock
Jondavid
J
Division of Radiation Oncology, Schiffler Cancer Center, Wheeling, WV, USA.
Welsh
James S
JS
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D015510:Clinical Medicine; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D044483:Intestinal Polyposis / Q000151:congenital / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics; D010580:Peutz-Jeghers Syndrome / Q000235:genetics; D015995:Prevalence; D011878:Radiotherapy / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000235:genetics