title: The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.
abstract: Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Jianxun
authors.initials: J
authors.lastname: Qi
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Vavricka
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Jinhua
authors.initials: J
authors.lastname: Wei
authors.forename: Enguang
authors.initials: E
authors.lastname: Feng
authors.forename: Jingshan
authors.initials: J
authors.lastname: Shen
authors.forename: Jilong
authors.initials: J
authors.lastname: Chen
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: He
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yan
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Maikun
authors.initials: M
authors.lastname: Teng
authors.forename: Xuebing
authors.initials: X
authors.lastname: Li
authors.forename: George F
authors.initials: GF
authors.lastname: Gao
mesh_terms: D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D053118:Influenza A Virus, H1N1 Subtype / Q000201:enzymology* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D009439:Neuraminidase / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid