title: The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death.
abstract: BACKGROUND
  Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and a substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD).
  
  
  METHODS
  Twenty-one patients with manifestations of HF and a left ventricular ejection fraction (LVEF) ≤50% were enrolled. The median age was 62 years and median LVEF was 33%. Time- and frequency-domain analysis of heart rate variability (HRV) on 24 h ambulatory electrocardiography recording was assessed. Serum markers of ECM turnover including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed.
  
  
  RESULTS
  The serum PIIINP concentration was correlated significantly with standard deviation of all normal to normal R-R intervals (SDNN) (r=-0.722, p=<0.001), percentage of adjacent NN interval differences >50 ms (pNN50) (r=-0.528, p=0.014), percentage of adjacent NN interval differences >20 ms (pNN20) (r=-0.545, p=0.002), very low frequency (VLF) (r=-0.490, p=0.024), low frequency (LF) (r=-0.491, p=0.024), and high frequency (HF) (r=-0.513, p=0.018). PINP, MMP-2, -9, TIMP-1 were not correlated with time- and frequency-domain analysis of HRV.
  
  
  CONCLUSIONS
  PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Yen-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.forename: Men-Tzung
authors.initials: MT
authors.lastname: Lo
authors.forename: Hung-Ju
authors.initials: HJ
authors.lastname: Lin
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Wu
authors.forename: Ron-Bin
authors.initials: RB
authors.lastname: Hsu
authors.forename: Chia-Lun
authors.initials: CL
authors.lastname: Chao
authors.forename: Hsiu-Ching
authors.initials: HC
authors.lastname: Hsu
authors.forename: Pa-Chun
authors.initials: PC
authors.lastname: Wang
authors.forename: Vin-Cent
authors.initials: VC
authors.lastname: Wu
authors.forename: Shoei-Shen
authors.initials: SS
authors.lastname: Wang
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Lee
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
authors.forename: Yi-Lwun
authors.initials: YL
authors.lastname: Ho
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
authors.forename: Chung-Kang
authors.initials: CK
authors.lastname: Peng
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D024061:Collagen Type III / Q000097:blood*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D015716:Electrocardiography, Ambulatory; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D024061:Collagen Type III