title: Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation.
abstract: The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl(4), BF(3)·Et(2)O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, UC-Davis Cancer Center, School of Medicine, 4501 X Street, Sacramento, CA 95817, USA.
authors.forename: Nianhuan
authors.initials: N
authors.lastname: Yao
authors.forename: Gabriel
authors.initials: G
authors.lastname: Fung
authors.forename: Hamed
authors.initials: H
authors.lastname: Malekan
authors.forename: Long
authors.initials: L
authors.lastname: Ye
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
authors.forename: Kit S
authors.initials: KS
authors.lastname: Lam
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids