MicroRNA roles in beta-catenin pathway.
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.
Huang
Kai
K
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhang
Jun-Xia
JX
Han
Lei
L
You
Yong-Ping
YP
Jiang
Tao
T
Pu
Pei-Yu
PY
Kang
Chun-Sheng
CS
D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
D035683:MicroRNAs; D051153:Wnt Proteins; D051176:beta Catenin