title: Transfusion-related acute lung injury (TRALI): A Canadian blood services research and development symposium.
abstract: Since the first description of transfusion-related acute lung injury (TRALI) more than 2 decades ago, we have only recently begun to learn how this disorder may occur and how to prevent it. Scientists from around the world have made great strides in identifying the possible causes of this condition. Blood banks and transfusion services have risen to the challenges of prevention. Recent introduction of restricting most plasma products to those obtained from male donors only has greatly reduced the incidence of TRALI worldwide. Scientists have recently identified the gene and protein for the human neutrophil antigen-3a associated with most mortality due to TRALI, and this presents an opportunity for a screening assay to prevent future TRALI-associated deaths. Finally, animal models of TRALI have provided insight into the possible mechanisms of this disorder and can be used to explore potential treatment modalities.
authors.affiliation: University of Ottawa and Ottawa General Hospital, Ottawa, Ontario, Canada.
authors.forename: Elianna
authors.initials: E
authors.lastname: Saidenberg
authors.forename: Tanya
authors.initials: T
authors.lastname: Petraszko
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Semple
authors.forename: Donald R
authors.initials: DR
authors.lastname: Branch
mesh_terms: D055371:Acute Lung Injury / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D001771:Blood Banks / Q000331:legislation & jurisprudence / Q000592:standards; D058731:Blood Safety / Q000379:methods / Q000639:trends; D001803:Blood Transfusion / Q000331:legislation & jurisprudence / Q000379:methods* / Q000639:trends; D002170:Canada; D003226:Congresses as Topic; D005260:Female; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D009313:National Health Programs / Q000458:organization & administration; D012106:Research / Q000458:organization & administration; D065227:Transfusion Reaction; D014181:Transplantation Immunology / Q000502:physiology; D006113:United Kingdom; D014481:United States; D000094902:Blood Banking / Q000379:methods