title: Pentraxin 3 as a novel marker predicting congestive heart failure in subjects with acute coronary syndrome.
abstract: OBJECTIVE
  Pentraxin 3 (PTX3) was shown to be elevated in the acute phase of acute myocardial infarction (AMI) and to have prognostic significance in AMI patients. The aim of this study was to estimate whether the value of PTX3 could be used as a prognostic biomarker, with the global registry of acute coronary events (GRACE) risk assessment tool, in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  Between July 2007 and June 2008, 137 patient subjects (mean age : 61±12 years, M : F=108 : 29) with ACS who underwent coronary intervention, but did not have a prior percutaneous coronary intervention (PCI) and/or follow-up coronary angiogram, were enrolled. We estimated the all-cause mortality or death/MI, in-hospital and to 6 months, using the GRACE risk scores and compared these estimates with serum PTX3 concentrations.
  
  
  RESULTS
  The serum PTX3 concentration showed a significant increase in ST segment elevation myocardial infarction (STEMI) greater than the unstable angina pectoris (UAP) group (2.4±2.1 ng/mL vs. 1.3±0.9 ng/mL, p= 0.017, respectively), but did not show a significant difference between non-ST segment elevation myocardial infarction (NSTEMI) and the UAP group (1.9±1.4 ng/mL vs. 1.3±0.9 ng/mL, p=0.083, respectively). The serum PTX3 concentration was closely related to death/MI in-hospital (r=0.242, p=0.015) and death/MI to 6 months (r=0.224, p=0.023), respectively. The serum PTX3 concentration was not related to all-cause mortality in-hospital (r=0.112, p=0.269) and to 6 months (r=0.132, p=0.191), respectively. Among the parameters determining the GRACE risk scores, the degree of Killip class in congestive heart failure (CHF) was independently associated with the supramedian PTX3 concentration [odds ratio: 2.229 (95% confidence interval: 1.038-4.787), p=0.040].
  
  
  CONCLUSIONS
  The serum PTX3 level provides important information for the risk stratification of CHF among the parameters determining the GRACE risk scores in subjects with ACS.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Dong-Hyeon
authors.initials: DH
authors.lastname: Lee
authors.forename: Hui-Kyung
authors.initials: HK
authors.lastname: Jeon
authors.forename: Ji-Han
authors.initials: JH
authors.lastname: You
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Park
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sung-Sik
authors.initials: SS
authors.lastname: Kim
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Shim
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Choi
authors.forename: Woo-Seung
authors.initials: WS
authors.lastname: Shin
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
authors.forename: Wook-Sung
authors.initials: WS
authors.lastname: Chung
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Kim