title: Antiviral treatment including entecavir plus tenofovir disoproxil fumarate for HBV reactivation following a rituximab-based regimen.
abstract: Entecavir and tenofovir disoproxil fumarate are potent and effective antiviral drugs that now represent recommended treatment options for chronic HBV infection. However, no or very limited clinical evidence is currently available on these drugs for the management of HBV reactivation in patients with haematological malignancies. Herein, we report a case of HBV reactivation in a patient with non-Hodgkin's lymphoma following a rituximab-based regimen, and who was successfully treated with a combination antiviral treatment including entecavir and tenofovir disoproxil fumarate.
authors.affiliation: Sapienza University, Polo Pontino, Latina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rago
authors.forename: Miriam
authors.initials: M
authors.lastname: Lichtner
authors.forename: Sergio
authors.initials: S
authors.lastname: Mecarocci
authors.forename: Raffaella
authors.initials: R
authors.lastname: Marocco
authors.forename: Natalia
authors.initials: N
authors.lastname: Cenfra
authors.forename: Valeria
authors.initials: V
authors.lastname: Belvisi
authors.forename: Cosmo
authors.initials: C
authors.lastname: Del Borgo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cimino
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Mastroianni
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D000069283:Rituximab; D000068698:Tenofovir; D014775:Virus Activation
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000998:Antiviral Agents; D004338:Drug Combinations; D063065:Organophosphonates; D000069283:Rituximab; C413685:entecavir; D006147:Guanine; D000068698:Tenofovir; D000225:Adenine