A young male heart transplant recipient who developed CKD due to cyclosporine therapy after a decade.
We report cyclosporine-induced chronic kidney disease (CKD) in a 38year old man who underwent cadaveric orthotopic heart transplant done 13 years ago. He was on triple immuno-suppression including micro-emulsion form of cyclosporine (neoral) with monitoring of his blood cyclosporine levels and serum creatinine. We discuss the pathophysiological mechanisms of cyclosporine toxicity in heart transplant recipients.
Chandramohan
Vaishnavi
V
Madras Medical Mission Hospital, Chennai.
Abraham
Georgi
G
Matthew
Milli
M
Mullassery
Ajith
A
Thirumoorthy
Kanchana
K
D000328:Adult; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine