title: Quick access to druglike heterocycles: facile silver-catalyzed one-pot multicomponent synthesis of aminoindolizines.
abstract: A direct and efficient approach to 1-aminoindolizines through three-component one-pot reaction of heteroaryl aldehydes, secondary amines, and terminal alkynes catalyzed by AgBF(4) has been developed. Desired products were obtained in moderate to excellent yields. Similar aminoindolizines products were afforded from trimethylsilyl protected alkyne substrates as well. This methodology provides a rapid access to construct a diversity-oriented library of indolizines.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Bai
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Jimei
authors.initials: J
authors.lastname: Ma
authors.forename: Bala Kishan
authors.initials: BK
authors.lastname: Gorityala
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Liu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D006571:Heterocyclic Compounds; D007212:Indolizines; D009942:Organometallic Compounds; D012834:Silver