The vitamin E-binding protein afamin is altered significantly in the peritoneal fluid of women with endometriosis.
The objective of this case-control study of 242 reproductive-age women was to determine the concentration of afamin in the serum and peritoneal fluid of women with and without endometriosis and to test afamin as a diagnostic marker of endometriosis. Afamin levels were altered significantly in the peritoneal fluid of women with endometriosis compared with disease-free controls, correlated with vitamin E levels, and are consistent with increased oxidative stress in the peritoneal cavity of women with endometriosis.
Seeber
Beata E
BE
Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, Austria. beata.seeber@uki.at
Czech
Theresa
T
Buchner
Hannes
H
Barnhart
Kurt T
KT
Seger
Christoph
C
Daxenbichler
Guenter
G
Wildt
Ludwig
L
Dieplinger
Hans
H
D000293:Adolescent; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009994:Osmolar Concentration; D018384:Oxidative Stress / Q000502:physiology; D010532:Peritoneal Diseases / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*; D000075462:Serum Albumin, Human; D014810:Vitamin E / Q000097:blood / Q000378:metabolism; D055815:Young Adult
C088246:AFM protein, human; D002352:Carrier Proteins; D006023:Glycoproteins; D012709:Serum Albumin; D014810:Vitamin E; D000075462:Serum Albumin, Human