title: Effects of 4-tert-octylphenol on the testes and seminal vesicles in adult male bank voles.
abstract: The present study was designed to evaluate the effects of 4-tert-octylphenol (OP) on male testes and seminal vesicles of bank vole. Adult males kept under long or short photoperiod were orally administered OP (200mg/kg bw) for 30 or 60 days. Treatment for 30 days had no discernible effect on the parameters examined. Treatment for 60 days adversely influenced weights and histological structure of the testes and seminal vesicles. In these tissues, expression of 3β-hydroxysteroid dehydrogenase and androgen receptor and testosterone levels were reduced, whereas expression of aromatase and estrogen receptor α and estradiol levels were increased. The alterations were more evident in voles kept in long photoperiod. Taken together, it is suggested that adverse changes in bank vole reproductive tissues induced by long-term OP-exposure result from disturbed androgen and estrogen synthesis and action. Moreover, there might be a subtle difference in the sensitivity to OP between voles kept in different light conditions.
authors.affiliation: Department of Endocrinology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland. anna.hejmej@uj.edu.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Hejmej
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kotula-Balak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Galas
authors.forename: Barbara
authors.initials: B
authors.lastname: Bilińska
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D003411:Arvicolinae / Q000502:physiology*; D052244:Endocrine Disruptors / Q000633:toxicity*; D004958:Estradiol / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000633:toxicity*; D017440:Photoperiod; D011944:Receptors, Androgen / Q000378:metabolism; D012669:Seminal Vesicles / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013501:Surface-Active Agents / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000378:metabolism
chemical_list: D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011944:Receptors, Androgen; D013501:Surface-Active Agents; D013739:Testosterone; D004958:Estradiol; D015096:3-Hydroxysteroid Dehydrogenases; D001141:Aromatase; C105260:4-tert-octylphenol