title: Dolabellane Diterpenoids from the South Atlantic Gorgonian Convexella magelhaenica.
abstract: Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations.
authors.affiliation: UMYMFOR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2 (1428), Buenos Aires, Argentina.
authors.forename: María Tereza
authors.initials: MT
authors.lastname: Rojo de Almeida
authors.forename: Gastón E
authors.initials: GE
authors.lastname: Siless
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Perez
authors.forename: María José
authors.initials: MJ
authors.lastname: Veloso
authors.forename: Laura
authors.initials: L
authors.lastname: Schejter
authors.forename: Lydia
authors.initials: L
authors.lastname: Puricelli
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Palermo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001267:Atlantic Ocean; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms / Q000188:drug therapy
chemical_list: C000606177:(1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one; C000606020:(1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one; D004224:Diterpenes; C115566:dolabellane