title: Methicillin-resistant Staphylococcus aureus colonization in HIV-infected outpatients is common and detection is enhanced by groin culture.
abstract: SUMMARYAlthough high rates of clinical infection with methicillin-resistant Staphylococcus aureus (MRSA) have been reported in HIV-infected adults, data on MRSA colonization are limited. We enrolled HIV-infected adults receiving care at the Atlanta VA Medical Center. Swabs from each participant's nares and groin were cultured with broth enrichment for S. aureus. Of 600 HIV-infected adults, 79 (13%) were colonized with MRSA and 180 (30%) with methicillin-susceptible S. aureus. MRSA pulsed-field gel electrophoresis types USA300 (n=44, 54%) and USA500/Iberian (n=29, 35%) predominated. Inclusion of groin swabs increased MRSA detection by 24% and USA300 detection by 38%. In multivariate analysis, MRSA colonization compared to no MRSA colonization was associated with a history of MRSA clinical infection, rarely or never using condoms, and contact with prisons and jails. In summary, the prevalence of MRSA colonization was high in this study of HIV-infected adults and detection of USA300 was enhanced by groin culture.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Peters
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Brooks
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: B
authors.initials: B
authors.lastname: Limbago
authors.affiliation: Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Lowery
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: McAllister
authors.affiliation: Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mindley
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Fosheim
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gorwitz
authors.affiliation: Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Guest
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hageman
authors.affiliation: Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Fridge
authors.affiliation: Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Rimland
mesh_terms: D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006119:Groin / Q000382:microbiology*; D015658:HIV Infections / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology