title: Regulator of G-protein signaling 14 protein modulates Ca²+ influx through Cav1 channels.
abstract: Calcium flux through L-type voltage-activated calcium (Cav1) channels is crucial for regulating brain functions including memory formation and behavior. Alterations in Ca²+ homeostasis have been linked to many cognitive disorders, and understanding the regulation of this process is crucial for their remedy. Therefore, here, we have evaluated the effect of a multifunctional protein known to be involved in memory functions called regulator of G-protein signaling 14 (RGS-14) on Cav1 channel activity in neuronal cell lines NG108-15 and SH-SY5Y. RGS-14 protein produced significant reduction in Ca²+ influx in both cell lines and this effect was dependent on nifedipine-sensitive Cav1 channels. Thus, our results provide evidence supporting the idea that RGS-14 may facilitate the cognitive processing by modulating Cav1 channel-mediated intracellular Ca²+ transients.
authors.affiliation: Laboratory of Neurobiology at CIMES, University of Malaga, Malaga, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Martín-Montañez
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Acevedo
authors.forename: Juan Félix
authors.initials: JF
authors.lastname: López-Téllez
authors.forename: Raymond Scott
authors.initials: RS
authors.lastname: Duncan
authors.forename: Antonio González
authors.initials: AG
authors.lastname: Mateos
authors.forename: José
authors.initials: J
authors.lastname: Pavía
authors.forename: Peter
authors.initials: P
authors.lastname: Koulen
authors.forename: Zafar U
authors.initials: ZU
authors.lastname: Khan
mesh_terms: D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D051242:Caveolin 1 / Q000378:metabolism*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D020710:RGS Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: C495540:CAV1 protein, human; D020746:Calcium Channels, L-Type; D051242:Caveolin 1; D020710:RGS Proteins; C491400:RGS14 protein, human; D002118:Calcium