The potential influence of plant polyphenols on the aging process.
Cellular senescence is characterized by cellular hypertrophy: cell growth in the absence of cell division. The genes that regulate this process can be activated or inactivated by numerous plant polyphenols such as resveratrol, quercetin, butein, fistein, piceatannol, curcumin. Many of these substances have been shown to lengthen the lifespan of invertebrates. Many of these compounds have other potential beneficial effects on lifespan as antiatherogenic or antineoplastic agents. Challenges to human testing of such substances on lifespan include determination of dosage, low bioavailability, time and resources necessary to conduct tests, and understanding which formulation of substances to use.
Cherniack
E Paul
EP
The Geriatrics Institute, University of Miami Miller School of Medicine, Division of Geriatrics and Gerontology, and the Geriatrics and Extended Care Service and Geriatric Research Education, and Clinical Center (GRECC) of the Miami Veterans Affairs Medical Center, Miami, FL, USA. evan.cherniack@va.gov
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D003474:Curcumin / Q000627:therapeutic use; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects; D010636:Phenols / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013267:Stilbenes; D014665:Vasodilator Agents; D003474:Curcumin; D000077185:Resveratrol