Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens.
BACKGROUND
Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children.


METHODS
Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.


CONCLUSIONS
Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.
Diallo
Tamsir O
TO
Inserm Unité 547, Institut Pasteur de Lille, Lille, France. tamsird@yahoo.fr
Remoue
Franck
F
Gaayeb
Lobna
L
Schacht
Anne-Marie
AM
Charrier
Nicole
N
De Clerck
Dick
D
Dompnier
Jean-Pierre
JP
Pillet
Sophie
S
Garraud
Olivier
O
N'Diaye
Abdoulaye A
AA
Riveau
Gilles
G
D000293:Adolescent; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D016207:Cytokines / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D008297:Male; D020066:Merozoite Surface Protein 1 / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology* / Q000502:physiology; D012548:Schistosoma haematobium / Q000276:immunology / Q000502:physiology; D012553:Schistosomiasis haematobia / Q000150:complications / Q000276:immunology* / Q000469:parasitology
D000909:Antibodies, Helminth; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D016207:Cytokines; D020066:Merozoite Surface Protein 1