A folding "framework structure" of Tetrahymena group I intron.
We have published the dynamic extended folding (DEF) method, which is a RNA secondary structure prediction approach-to simulate the in vivo RNA co-transcriptional folding process. In order to verify the reliability of the method, we selected the X-ray-determined Tetrahymena group I intron as a sample to construct the framework of its folding secondary structure. Our prediction coincides well with the secondary structure predicted by T.R. Cech and the X-ray diffraction crystal structure determined by Lehnert V. Our results show that the DEF framework structure of Tetrahymena group I intron reflects its function sites in a concise and straightforward manner, and the scope of the simulation was expanded.
Zhang
Xi
X
Modern Biological Research Center, Yunnan University, Kunming 650091, China.
Guo
Chen
C
Zhang
Wen
W
Cao
Huai
H
Xie
Huazhen
H
Wang
Kan
K
Liu
Ciquan
C
D001483:Base Sequence; D007438:Introns / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics*; D013768:Tetrahymena / Q000235:genetics*
D012313:RNA