title: Hepatotoxicity of alpha-methyldopa in pregnancy.
abstract: Alpha-methyldopa is one of the most widely prescribed antihypertensive agents used during pregnancy. Despite its known potential hepatotoxicity, there have been only a few reports describing hepatotoxicity with the use of this drug during pregnancy. We report here a new case of acute hepatitis in a pregnant woman related to the use of alpha-methyldopa, and briefly review the literature on alpha-methyldopa-induced hepatotoxicity in pregnancy.
authors.affiliation: Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia. raoudha_slim3@yahoo.fr
authors.forename: R
authors.initials: R
authors.lastname: Slim
authors.forename: C
authors.initials: C
authors.lastname: Ben Salem
authors.forename: H
authors.initials: H
authors.lastname: Hmouda
authors.forename: K
authors.initials: K
authors.lastname: Bouraoui
mesh_terms: D000208:Acute Disease; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy; D008750:Methyldopa / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D000959:Antihypertensive Agents; D008750:Methyldopa