title: Genotypic characterization of tuberculosis transmission within Toronto's under-housed population, 1997-2008.
abstract: Toronto has been the site of a recent extended tuberculosis (TB) outbreak in the homeless or under-housed population. Genotyping has identified a unique strain that continues to circulate within this population, with spread to individuals with no links to the shelter system, and anecdotally appears to progress rapidly from infection to active disease in some cases. The recent appearance and transmission of another unique strain was also identified, indicating that TB transmission continues to be a problem within the under-housed population. Enhanced surveillance utilizing molecular epidemiology is a useful tool to assist in TB control in vulnerable populations.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: H J
authors.initials: HJ
authors.lastname: Adam
authors.forename: J L
authors.initials: JL
authors.lastname: Guthrie
authors.forename: S
authors.initials: S
authors.lastname: Bolotin
authors.forename: D C
authors.initials: DC
authors.lastname: Alexander
authors.forename: R
authors.initials: R
authors.lastname: Stuart
authors.forename: D
authors.initials: D
authors.lastname: Pyskir
authors.forename: E M
authors.initials: EM
authors.lastname: Brown
authors.forename: E
authors.initials: E
authors.lastname: Rea
authors.forename: P
authors.initials: P
authors.lastname: Chedore
authors.forename: F B
authors.initials: FB
authors.lastname: Jamieson
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003140:Communicable Disease Control / Q000379:methods; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006703:Ill-Housed Persons / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D009864:Ontario / Q000453:epidemiology; D010641:Phenotype; D011159:Population Surveillance; D011634:Public Health; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission*; D014505:Urban Population / Q000706:statistics & numerical data*