Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro.
Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.
Zhao
Lu
L
Department of Obstetrics and Gynecology, First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Li
Wei
W
Han
Fengjuan
F
Hou
Lihui
L
Baillargeon
Jean-Patrice
JP
Kuang
Haixue
H
Wang
Yongyan
Y
Wu
Xiaoke
X
D001599:Berberine / Q000494:pharmacology*; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D017588:Hyperandrogenism / Q000378:metabolism*; D066298:In Vitro Techniques; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D013799:Theca Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D005938:Glucocorticoids; D001599:Berberine; D003907:Dexamethasone; D005947:Glucose