title: A Bisindole Alkaloid with Hedgehog Signal Inhibitory Activity from the Myxomycete Perichaena chrysosperma.
abstract: 6-Hydroxy-9'-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9'-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Shintani
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Toume
authors.forename: Yusnita
authors.initials: Y
authors.lastname: Rifai
authors.forename: Midori A
authors.initials: MA
authors.lastname: Arai
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000818:Animals; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D015394:Molecular Structure; D009235:Myxomycetes / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D026121:Indole Alkaloids