title: Genomic profiling of sinonasal squamous cell carcinoma.
abstract: BACKGROUND
  Sinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SCC.
  
  
  METHODS
  DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.
  
  
  RESULTS
  Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13.
  
  
  CONCLUSIONS
  The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology.
authors.affiliation: Department of Otolaryngology, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: López
authors.forename: José L
authors.initials: JL
authors.lastname: Llorente
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Inclán
authors.forename: Marta
authors.initials: M
authors.lastname: Alonso-Guervós
authors.forename: Mari Paz
authors.initials: MP
authors.lastname: Cuesta-Albalad
authors.forename: Manuel Florentino
authors.initials: MF
authors.lastname: Fresno
authors.forename: César
authors.initials: C
authors.lastname: Alvarez-Marcos
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez
authors.forename: Mario A
authors.initials: MA
authors.lastname: Hermsen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005784:Gene Amplification; D016158:Genes, p53 / Q000235:genetics*; D016678:Genome; D006258:Head and Neck Neoplasms / Q000235:genetics; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000235:genetics; D046228:Microarray Analysis; D008875:Middle Aged; D009154:Mutation; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor