[Prolonged bone marrow aplasia in patients with acute leukemia after chemotherapy].
OBJECTIVE
To analyze the causes of prolonged hematopoietic tissue aplasias in patients with acute leukemias (AL) after chemotherapy courses.


METHODS
Data on 7 patients with acute myeloid leukemia, followed up at the Hematology Departments, Hematology Research Center, Russian Academy of Medical Sciences, over the period 2003 to 2007, who had developed deep bone marrow aplasia (BMA) inadequate to cytostatic drug exposure during chemotherapy, were analyzed. The authors compared in all the patients the values of peripheral blood and bone marrow (BM) puncture specimens and the results of blood tests using the polymerase chain reaction at different AL development stages with the results of an immunohistochemical study using the markers of viruses of hepatitis C and B, a herpes group (EBV, CMV, HSV-1, HSV-2) and parvovirus B19.


RESULTS
The marker of hepatitis C was detected in 6 of the 7 patients with prolonged BMA; 3 of these 6 patients showed a simultaneous infection with hepatitis B. Six of the 7 patients were found to have concomitant BM lesion with various herpes group viruses. Two patients had a resistant form of AL.


CONCLUSIONS
Hepatitis C virus infection in patients and the resistant form of the disease were the principal causes of the development of BMA inadequate to cytostatic drug exposure. Affliction of abundant bone marrow cells with herpes group viruses was not a direct cause, but might substantially aggravate BMA.
Gaĭdamaka
N V
NV
Parovichnikova
E N
EN
Zavalishina
L E
LE
Garmaeva
T Ts
TTs
Gaponova
T V
TV
Troitskaia
V V
VV
Pokrovskaia
O S
OS
Tikhomirov
D S
DS
Khodunova
E E
EE
Mar'in
D S
DS
Kaplanskaia
I B
IB
Ustinova
E N
EN
Mikhaĭlova
E A
EA
Isaev
V G
VG
Gribanova
E O
EO
Savchenko
V G
VG
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000209:etiology* / Q000821:virology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology / Q000821:virology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D016174:Hepacivirus / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D007970:Leukopenia / Q000209:etiology / Q000821:virology; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology / Q000821:virology; D013997:Time Factors; D055815:Young Adult