title: Nasal septal perforation closure with bacterial cellulose in rabbits.
abstract: Alloplastic materials can be used together with tissue and structure to close nasal septal perforation.
  
  
  OBJECTIVE
  to test cellulose use in the closure of septal perforation in rabbits and to compare fibrosis, inflammation, vascular congestion and graft integrity.
  
  
  METHODS
  Fifteen rabbits. The rabbits were divided into two groups:
  
  
  METHODS
  Five rabbits and Bionext and fibrin glue Tissucol: Ten rabbits. Septal perforations were done in all of them. In the Bionext group the closure was performed with the placement of cellulose.
  
  
  RESULTS
  Two rabbits died in the first week. Cellulose group: 2 closures without the cellulose in between the septum membrane and in 4 cases the graft stood in the middle of the perforation locked in place by the edges. No closure in the control group.
  
  
  CONCLUSIONS
  There was no closure of the perforation of the nasal septum with the graft between the septum membranes. There was no statistically significant difference concerning acute inflammation, vascular congestion and fibrosis between the 2 groups. In cases in which the graft remained in place, there was no change in its integrity. It may be used as a substructure for re-epithelization of the perforation edges.
authors.affiliation: Faculdade de Medicina da Santa Casa de São Paulo.
authors.forename: Eulógio Emílio
authors.initials: EE
authors.lastname: Martinez Neto
authors.forename: Jose Eduardo Lutaif
authors.initials: JE
authors.lastname: Dolci
mesh_terms: D000818:Animals; D001684:Biological Dressings; D002482:Cellulose / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D041822:Gluconacetobacter xylinus; D009300:Nasal Septum / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D011817:Rabbits; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D002482:Cellulose