Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.
Kojima
Yoshihiro
Y
United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan.
Kimura
Toshiyuki
T
Nakagawa
Kiyotaka
K
Asai
Akira
A
Hasumi
Keiji
K
Oikawa
Shinichi
S
Miyazawa
Teruo
T