title: Serotonin and catecholaminergic polymorphic ventricular tachycardia: a possible therapeutic role for SSRIs?
abstract: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare malignant arrhythmia, usually diagnosed in the adolescent years. The diagnosis can typically be made by one or more of the following: a positive family history, exercise electrocardiography, ambulatory ECG monitoring and/or an intra-cardiac, electrophysiological examination. This is a case report of a patient with CPVT that was refractory to treatment with beta-blockade and an implanted automatic cardioverter defibrillator. However, after a selective serotonin re-uptake inhibitor (SSRI) was added to the therapeutic regimen, no further episodes of ventricular tachycardia occurred during the following two years.
authors.affiliation: Department of Cardiology, 10th People's Hospital of Tongji University, Shanghai, China.
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Duan
authors.forename: K
authors.initials: K
authors.lastname: Tang
authors.forename: D
authors.initials: D
authors.lastname: Zhao
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D002395:Catecholamines; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors