title: Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma.
abstract: BACKGROUND
  The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully.
  
  
  METHODS
  Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0.
  
  
  RESULTS
  There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis.
  
  
  CONCLUSIONS
  The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, Koga, Japan. paper7777@yahoo.co.jp
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Nozoe
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Akinori
authors.initials: A
authors.lastname: Egashira
authors.forename: Eisuke
authors.initials: E
authors.lastname: Adachi
authors.forename: Akito
authors.initials: A
authors.lastname: Matsukuma
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ezaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D014680:Veins / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D012709:Serum Albumin; D002097:C-Reactive Protein