title: Electrospun functionalized polyaniline copolymer-based nanofibers with potential application in tissue engineering.
abstract: Nanofibrous blends of HCl-doped poly(aniline-co-3-aminobenzoic acid) (3ABAPANI) copolymer and poly(lactic acid) (PLA) were fabricated by electrospinning solutions of the polymers, in varying relative proportions, in dimethyl sulfoxide/tetrahydrofuran mixture. The morphology, mechanical and electrical properties of the nanofibers were characterized and an assessment of their bioactivity performed. To assess cell morphology and biocompatibility, pure PLA and 3ABAPANI-PLA nanofibrous mats were deposited in the form of three-dimensional networks with a high degree of connectivity, on glass substrates, and their ability to promote proliferation of COS-1 fibroblast cells was determined. The nanofibrous electrospun 3ABAPANI-PLA blends gave enhanced cell growth, potent antimicrobial capability against Staphylococcus aureus and electrical conductivity. This new class of nanofibrous blends can potentially be employed as tissue engineering scaffolds, and in particular have showed promise as the basis of a new generation of functional wound dressings that may eliminate deficiencies of currently available antimicrobial dressings.
authors.affiliation: Department of Chemistry, Faculty of Science, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. m.gizdavic@auckland.ac.nz
authors.forename: Marija
authors.initials: M
authors.lastname: Gizdavic-Nikolaidis
authors.forename: Sudip
authors.initials: S
authors.lastname: Ray
authors.forename: Jared R
authors.initials: JR
authors.lastname: Bennett
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Easteal
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Cooney
mesh_terms: D062365:Aminobenzoates / Q000737:chemistry* / Q000494:pharmacology; D000814:Aniline Compounds / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001458:Bandages; D019556:COS Cells; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004121:Dimethyl Sulfoxide; D004553:Electric Conductivity; D005663:Furans; D019344:Lactic Acid / Q000737:chemistry* / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D023822:Tissue Engineering / Q000379:methods*; D062368:meta-Aminobenzoates
chemical_list: D062365:Aminobenzoates; D000814:Aniline Compounds; D005663:Furans; D011091:Polyesters; D011108:Polymers; D062368:meta-Aminobenzoates; C416807:polyaniline; D019344:Lactic Acid; C018674:tetrahydrofuran; C033616:poly(lactide); C044855:3-aminobenzoic acid; D004121:Dimethyl Sulfoxide