title: [Novel approaches for the prevention of influenza: the intradermal vaccination].
abstract: Conventional non-adjuvanted influenza vaccines have shown suboptimal immunogenicity in subjects at high risk for complications, such as the elderly. Between the several strategies proposed to develop more immunogenic vaccines than the conventional ones, a promising option is represented by the administration of non-adjuvanted vaccine through the intradermal (ID) route. This paper summarizes and discusses the main results recently obtained in clinical trials investigating the safety, tolerability and immunogenicity of new ID influenza vaccines, containing standard or reduced antigen dosages, in different age-groups.
authors.affiliation: Dipartimento di Scienze della Salute, Università degli Studi di Genova, Ambulatorio Vaccinazioni e Sperimentazioni Cliniche, Genova.
authors.forename: Paolo
authors.initials: P
authors.lastname: Durando
authors.forename: Laura
authors.initials: L
authors.lastname: Sticchi
authors.forename: Marisa
authors.initials: M
authors.lastname: Alberti
authors.forename: Cristiano
authors.initials: C
authors.lastname: Alicino
authors.forename: Rocco
authors.initials: R
authors.lastname: Iudici
authors.forename: Mariano
authors.initials: M
authors.lastname: Martini
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Icardi
mesh_terms: D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000517:prevention & control*; D007271:Injections, Intradermal
chemical_list: D007252:Influenza Vaccines