Understanding the structure and function of the immunological synapse.
The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.
Dustin
Michael L
ML
Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, New York 10016, USA.
Chakraborty
Arup K
AK
Shaw
Andrey S
AS
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D016764:Cell Polarity / Q000276:immunology; D006801:Humans; D054992:Immunological Synapses / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell