title: Negative ECG-gated cardiac CT in patients with low-to-moderate risk chest pain in the emergency department: 1-year follow-up.
abstract: OBJECTIVE
  The purpose of this article is to determine the frequency of adverse cardiac events during the year following a negative cardiac CT angiogram in a population of patients presenting to the emergency department with low-to-moderate risk chest pain.
  
  
  METHODS
  Eighty-one consecutive patients who had standard of care evaluation for low-to-moderate risk chest pain in the emergency department were enrolled and consented to have a cardiac CT angiogram added to their workup and to have follow-up for 1 year. Eleven patients were excluded, six because their cardiac CT examinations were unsuccessful, four because of a positive cardiac CT angiogram result, and one was lost to follow-up. Seventy patients with negative cardiac CT angiographic results (< 50% stenosis) were included and were interviewed in detail at 3, 6, and 12 months about intervening cardiac events, diagnostic testing, and therapy. Electronic medical records were also reviewed at each time point.
  
  
  RESULTS
  None of the 70 patients reported an adverse cardiac event over the 12-month follow-up period. At 1 year, the cause of chest pain was unknown in 49 patients, gastrointestinal in nine patients, anxiety in seven patients, musculoskeletal in three patients, and other in two patients. Three of four patients with 50% or greater stenosis on their cardiac CT had subsequent cardiac catheterization and stent placement.
  
  
  CONCLUSIONS
  In patients with low-to-moderate risk chest pain evaluated in the emergency department, adverse cardiac events may be rare during the 12 months following a negative cardiac CT angiogram.
authors.affiliation: Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, USA. wshuman@u.washington.edu
authors.forename: William P
authors.initials: WP
authors.lastname: Shuman
authors.forename: Janet M
authors.initials: JM
authors.lastname: May
authors.forename: Kelley R
authors.initials: KR
authors.lastname: Branch
authors.forename: Lee M
authors.initials: LM
authors.lastname: Mitsumori
authors.forename: Jared N
authors.initials: JN
authors.lastname: Strote
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Green
authors.forename: James H
authors.initials: JH
authors.lastname: Caldwell
mesh_terms: D002637:Chest Pain / Q000175:diagnosis*; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed