Signaling defects and the nuclear envelope in progeria.
Hutchinson-Gilford progeria syndrome is a rare childhood genetic disorder with features of accelerated aging. In this issue, Hernandez et al. observe decreased Wnt signaling and extracellular matrix gene expression in a murine model of the disease, suggesting potential therapeutic strategies and further emphasizing the nuclear envelope's role in signal transduction.
Muchir
Antoine
A
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Worman
Howard J
HJ