Serum leptin, adiponectin and tumor necrosis factor-α in hyperlipidemic rats with/without concomitant diabetes mellitus.
We compared the lipid profiles and serum levels of leptin, adiponectin and tumor necrosis factor-α (TNF-α) in rats with/without hyperlipidemia and with/without concomitant diabetes mellitus. Forty 10-wk-old male Wistar rats were divided into four groups. Groups A and C received standard food for 12 wks. Groups B and D received a high-fat diet enriched with 2% additional cholesterol. Moreover, insulin-deficient (type I) diabetes mellitus was induced in rats in groups C and D with intraperitoneal injections of streptozotocin. Fasting serum leptin levels were decreased in diabetic groups (groups C and D) compared with controls. Fasting serum adiponectin levels were decreased in groups C and D compared with group A. Serum TNF-α levels were augmented in groups B and D, those fed with an atherogenic diet. By contrast, TNF-α levels were decreased in group C. Our data suggest that serum leptin, adiponectin and TNF-α levels may serve as markers of obesity and type I diabetes mellitus.
Margoni
Angeliki
A
Department of Biological Chemistry, University of Athens Medical School, Athens, Greece.
Perrea
Despoina N
DN
Vlachos
Ioannis
I
Prokopaki
Georgia
G
Pantopoulou
Alkistis
A
Fotis
Lambros
L
Kostaki
Maria
M
Papavassiliou
Athanasios G
AG
D052242:Adiponectin / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha