Non-Gaussian noise-optimized intracellular cytosolic calcium oscillations.
We have numerically studied the effect of a particular kind of non-Gaussian colored noise (NGN), characterized by the deviation q from Gaussian noise (q=1), on intracellular cytosolic calcium (Ca(2+)) oscillations. It is found that, as q is increased, the Ca(2+) oscillation regularity increases and reaches a best performance at an optimal q, and then decreases with further increasing q, which represents the occurrence of coherence resonance, i.e., the most regular Ca(2+) oscillations. Similar phenomena occur for different values of noise intensity and correlation time of the NGN. This phenomenon of deviation-optimized Ca(2+) oscillations show that, external non-Gaussian noises of different types can enhance and even optimize the intracellular Ca(2+) oscillations. This result provides new insights into the constructive roles and potential applications of non-Gaussian noises in intracellular cytosolic Ca(2+) oscillations.
Gong
Yubing
Y
School of Physics, Ludong University, Yantai, Shandong, PR China. gongyubing09@hotmail.com
Xie
Yanhang
Y
Lin
Xiu
X
Hao
Yinghang
Y
D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D003600:Cytosol / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D008962:Models, Theoretical; D013269:Stochastic Processes
D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium