Gene polymorphisms and related risk factors in Mongolian hypertensive stroke patients.
OBJECTIVE
To identify susceptible single nucleotide polymorphisms causing prevailing essential hypertension complicating stroke in the Mongolian population.


METHODS
This study was carried out at the Beijing Huada Genome Company, Beijing, and the Clinical Testing Center of Inner Mongolia Medical College, Hohhot, P.R. China from March to November 2005, and included 96 patients with hypertension (control group) with an average age of 53 +/- 11 years, and 68 patients with hypertensive stroke with an average age of 60 +/- 10 years. The gene polymorphisms were examined by the polymerase chain reaction-restriction fragment length polymorphism technique and the Sequenom system, and analyzed by multiple regression analysis.


RESULTS
Logistic multiple regression analysis revealed significant differences between the groups for age and smoking. Genotypes and allele gene frequencies were not significantly different between the groups. The significant incidence risks were p = 0.011, odds ration (OR) = 3.182 for the ACE DD genotype, p = 0.038, OR = 6.179 for the CYP CT genotype, and p = 0.042, OR = 6.089 for the CYP TT genotype. All the other genotypes did not significantly correlate to hypertension and hypertensive stroke.


CONCLUSIONS
The ACE DD, CYP CT andTT genotypes are candidates for hypertension complicating stroke in the Mongolian population. The risk of disease was lowest among the ACE II and CYP CC genotypes.
Huriletemuer
Huriletemuer
H
Department of Neurology and Image, First Affiliated Hospital, Inner Mongolia, PR China. hurilt@126.com
Zhang
Chunyu
C
Niu
Guangming
G
Zhao
Shigang
S
Hurile
Hurile
H
D000328:Adult; D000368:Aged; D000085962:Angiotensin-Converting Enzyme 2; D002681:China / Q000453:epidemiology / Q000208:ethnology; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000235:genetics*
D019405:Cytochrome P-450 CYP11B2; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2