title: Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome.
abstract: OBJECTIVE
  To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS).
  
  
  METHODS
  This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease.
  
  
  RESULTS
  A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4-73.5 ng/mL) and 10 (0-87.5), respectively. Spearman's correlation coefficient did not show a significant association between MPO levels and Gensini scores (r (s) = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥ 2 × ULN (upper limit of normal), TIMI risk score ≥ 4 and Gensini score in the multivariate analysis.
  
  
  CONCLUSIONS
  Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS.
authors.affiliation: Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003 Porto Alegre, RS, Brazil. ealucio@terra.com.br
authors.forename: Eraldo
authors.initials: E
authors.lastname: de Azevedo Lucio
authors.forename: Sandro C
authors.initials: SC
authors.lastname: Gonçalves
authors.forename: Jorge P
authors.initials: JP
authors.lastname: Ribeiro
authors.forename: Gilberto L
authors.initials: GL
authors.lastname: Nunes
authors.forename: Jarbas R
authors.initials: JR
authors.lastname: de Oliveira
authors.forename: Gustavo N
authors.initials: GN
authors.lastname: Araujo
authors.forename: Marco V
authors.initials: MV
authors.lastname: Wainstein
mesh_terms: D054058:Acute Coronary Syndrome / Q000473:pathology*; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology* / Q000473:pathology*; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D012307:Risk Factors
chemical_list: D009195:Peroxidase