title: Potential therapeutic applications of metal compounds directed towards hypoxic tissues.
abstract: Medicinal Inorganic Chemistry offers the high diversity of metal coordination chemistry for the development of bioactive compounds for therapeutic or diagnostic medicinal purposes. The design of novel metal-based antitumor agents occupies a privileged position in this discovery process. On the other hand, the research on metal-based radiopharmaceuticals for therapy and imaging is a subarea of high priority and development. This review describes therapeutic applications of metal compounds directed towards hypoxic tissues. Strategies in the search for new bioreductive metal-based prodrugs will be discussed. In addition, approaches for the imaging of hypoxic tissues by using metal radionuclides will be exemplified.
authors.affiliation: Cátedra de Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay. dgambino@fq.edu.uy
authors.forename: D
authors.initials: D
authors.lastname: Gambino
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D015687:Cell Hypoxia; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D008670:Metals / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D008670:Metals; D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals