title: Reconstruction of nasal deformity in Wegener's granulomatosis: contraindication or benefit?
abstract: BACKGROUND
  Saddle-nose deformity is a well-recognized stigma of patients affected by Wegener granulomatosis (WG). However, plastic surgical repair is seldom performed. In this study, the authors aimed to evaluate their own patients exclusively reconstructed by costal cartilage L-strut of the nose for this specific deformity.
  
  
  METHODS
  During a 5-year-period, four women with an average age of 33 years underwent reconstructive rhinoplasty of their saddle-nose deformity caused by WG, which in every case was in remission regarding the nose at the time of surgery. Restoration of the nasal framework was performed by an L-shaped rib cartilage graft.
  
  
  RESULTS
  The external form and function of the newly reconstructed nose was preserved during an average follow-up period of 42 months for all the patients. No resorption of the rib cartilage graft was observed. A review of the literature found a total of 22 nasal reconstructions for patients affected by WG.
  
  
  CONCLUSIONS
  According to this patient series and a review of the literature, external nasal reconstruction for patients affected by WG appears to be safe and effective if the disease is in remission before any operation. Despite concern that high-dose immune suppression therapy may increase the risk of failure in primary nasal dorsal repair, this could not be observed in the patients of this series, all of whom were receiving immunosuppressive medication. Therefore, nasal reconstruction to improve the physical appearance and thus the psychological well-being of these chronically ill patients seems to be justified.
authors.affiliation: Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Germany.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Vogt
authors.forename: Andreas
authors.initials: A
authors.lastname: Gohritz
authors.forename: Marion
authors.initials: M
authors.lastname: Haubitz
authors.forename: Andreas
authors.initials: A
authors.lastname: Steiert
mesh_terms: D000328:Adult; D000075202:Contraindications; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D009667:Nose Deformities, Acquired / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D017060:Patient Satisfaction; D012189:Retrospective Studies; D012225:Rhinoplasty / Q000379:methods*; D018570:Risk Assessment; D017751:Safety Management; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology