title: Data-guide for brain deformation in surgery: comparison of linear and nonlinear models.
abstract: BACKGROUND
  Pre-operative imaging devices generate high-resolution images but intra-operative imaging devices generate low-resolution images. To use high-resolution pre-operative images during surgery, they must be deformed to reflect intra-operative geometry of brain.
  
  
  METHODS
  We employ biomechanical models, guided by low resolution intra-operative images, to determine location of normal and abnormal regions of brain after craniotomy. We also employ finite element methods to discretize and solve the related differential equations. In the process, pre- and intra-operative images are utilized and corresponding points are determined and used to optimize parameters of the models. This paper develops a nonlinear model and compares it with linear models while our previous work developed and compared linear models (mechanical and elastic).
  
  
  RESULTS
  Nonlinear model is evaluated and compared with linear models using simulated and real data. Partial validation using intra-operative images indicates that the proposed models reduce the localization error caused by brain deformation after craniotomy.
  
  
  CONCLUSIONS
  The proposed nonlinear model generates more accurate results than the linear models. When guided by limited intra-operative surface data, it predicts deformation of entire brain. Its execution time is however considerably more than those of linear models.
authors.affiliation: Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Hamidian
authors.forename: Hamid
authors.initials: H
authors.lastname: Soltanian-Zadeh
authors.forename: Reza
authors.initials: R
authors.lastname: Faraji-Dana
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Gity
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D007432:Intraoperative Period; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D017711:Nonlinear Dynamics; D057234:Preoperative Period; D025321:Surgery, Computer-Assisted / Q000379:methods*