title: Comparison of the inhibitory effect of T-2 toxin on bovine platelet function with that of other known platelet inhibitors.
abstract: The inhibitory effects of T-2 toxin on bovine platelet function and thromboxane A(2) production were compared with those of the known inhibitors of human platelet function, acetylsalicylic acid, dipyridamole and verapamil. T-2 toxin (1 × 10(-3)M) effectively inhibited bovine platelet aggregation (33.2-64.3%), whereas neither acetylsalicylic acid nor dipyridamole did so. T-2 toxin appeared to be a less effective inhibitor of platelet aggregation than the calcium channel blocker, verapamil. T-2 toxin (1 × 10(-3)M) added to platelet suspensions together with verapamil, produced an additive inhibitory response. T-2 toxin (2.5 × 10(-4)M) effectively inhibited the release of thromboxane A(2) from ADP-stimulated bovine platelets as did acetylsalicylic acid and verapamil but not dipyridamole. T-2 toxin appears to inhibit bovine platelets by a biochemical mechanism distinct from that of the other inhibitors.
authors.affiliation: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
authors.forename: G S
authors.initials: GS
authors.lastname: Bondy
authors.forename: P A
authors.initials: PA
authors.lastname: Gentry