A context-sensitive mechanism in hippocampal CA1 networks.
This paper presents a possible context-sensitive mechanism in a neural network and at single neuron levels based on the experiments of hippocampal CA1 and their theoretical models. First, the spatiotemporal learning rule (STLR, non-Hebbian) and the Hebbian rule (HEBB) are experimentally shown to coexist in dendrite-soma interactions in single hippocampal pyramidal cells of CA1. Second, the functional differences between STLR and HEBB are theoretically shown in pattern separation and pattern completion. Third, the interaction between STLR and HEBB in neural levels is proposed to play an important role in forming a selective context determined by value information, which is related to expected reward and behavioral estimation.
Tsukada
Minoru
M
Brain Science Institute, Tamagawa University, 6-1-1, Tamagawagakuen, Machida, Tokyo, 194-0041, Japan. tsukada@eng.tamagawa.ac.jp
Fukushima
Yasuhiro
Y
D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D004558:Electric Stimulation; D006801:Humans; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats
D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine