title: In vivo antioxidant and hypolipidemic effect OF Cardiospermum halicacabum leaf extract in streptozotocin-induced diabetic rats.
abstract: In this study we investigated the antioxidant and antihyperlipidemic of an ethanolic leaf extract of Cardiospermum halicacabum (CHE) in plasma and tissues of streptozotocin (STZ)-induced diabetic rats. The plasma and tissue concentrations of thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxide were significantly elevated in STZ diabetic rats. CHE administration decreased TBARS and lipid hydroperoxide levels. The plasma vitamin E level increased and the vitamin C level decreased. The reduced glutathione level significantly decreased in plasma and tissues, as did the activities of enzymatic antioxidants. The enzymatic and non enzymatic alterations reversed toward normalcy after treatment with CHE. STZ-induced diabetic rats showed significant increases in plasma total cholesterol, phospholipids, triglycerides, and free fatty acids, which returned to near normalcy in CHE-treated animals. Plasma LDL-C and VLDL-C increased and HDL-C decreased and both reverted to near normalcy following CHE treatment. We conclude that CHE possesses antioxidant and hypolipidemic effects in diabetic rats, which may be due to the presence of flavonoids, such as apigenin and luteolin in the extract.
authors.affiliation: Department ofBiochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.
authors.forename: Chinnaveeramani
authors.initials: C
authors.lastname: Veeramani
authors.forename: Ganesan
authors.initials: G
authors.lastname: Pushpavalli
authors.forename: Kodukkur Viswanathan
authors.initials: KV
authors.lastname: Pugalendi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D029631:Sapindaceae / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances