Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition.
Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism. Both the Aβ plaque deposition and the changes in metabolism appear to be concentrated in the brain's default-mode network. In contrast to prior studies of brain metabolism which viewed brain metabolism from a unitary perspective that equated glucose utilization with oxygen consumption, we here report on regional glucose use apart from that entering oxidative phosphorylation (so-called "aerobic glycolysis"). Using PET, we found that the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Aβ deposition in individuals with DAT and cognitively normal participants with elevated Aβ, suggesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology.
Vlassenko
Andrei G
AG
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Vaishnavi
S Neil
SN
Couture
Lars
L
Sacco
Dana
D
Shannon
Benjamin J
BJ
Mach
Robert H
RH
Morris
John C
JC
Raichle
Marcus E
ME
Mintun
Mark A
MA
D000328:Adult; D000544:Alzheimer Disease / Q000378:metabolism*; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D049268:Positron-Emission Tomography
D000682:Amyloid; D005947:Glucose; D010100:Oxygen