Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion.
BACKGROUND
Quit attempts may have different outcomes based on menstrual cycle phase on quit day. This is the first preliminary study examining whether smoking cessation outcomes vary by menstrual cycle phase of quit date in women receiving a 6-week open trial of sustained release (SR) bupropion.


METHODS
Thirty-three treatment-seeking premenopausal women were studied. Abstinence outcomes were compared for women quitting during the luteal versus follicular phase.


RESULTS
Women receiving bupropion SR whose self-selected quit date occurred in the luteal phase had significantly higher rates of point prevalence abstinence during the final week of a 6-week post-quit treatment period than women quitting in the follicular phase (62.5% versus 29.4%; p<0.05). A similar, but non-significant, pattern of findings was demonstrated for continuous abstinence during the treatment phase and for point prevalence abstinence at 3-month follow-up.


CONCLUSIONS
Women receiving bupropion SR were significantly more likely to be abstinent at treatment completion if quitting occurred during the luteal phase. This is consistent with recent findings of outcome related to cycle phase at quit date in the absence of pharmacotherapy, and differs from findings utilizing nicotine replacement. Results add to emerging data suggesting that smoking cessation interventions with varying mechanisms of action may result in different outcomes for premenopausal women based on gonadal hormones at quit date.
Mazure
Carolyn M
CM
Women's Health Research at Yale, 135 College Street, Suite 220, New Haven, CT 06510, USA. carolyn.mazure@yale.edu
Toll
Benjamin
B
McKee
Sherry A
SA
Wu
Ran
R
O'Malley
Stephanie S
SS
D000328:Adult; D016642:Bupropion / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005498:Follicular Phase / Q000097:blood / Q000187:drug effects* / Q000523:psychology; D006801:Humans; D008183:Luteal Phase / Q000097:blood / Q000187:drug effects* / Q000523:psychology; D008597:Menstrual Cycle / Q000097:blood / Q000187:drug effects / Q000523:psychology; D012907:Smoking / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology; D013997:Time Factors; D016896:Treatment Outcome
D016642:Bupropion