title: Heterocellular induction of interferon by negative-sense RNA viruses.
abstract: The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells.
authors.affiliation: School of Biology, Centre for Biomolecular Sciences, BMS Building, North Haugh, University of St. Andrews, St. Andrews, Fife, KY16 9ST, UK.
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: J A L
authors.initials: JA
authors.lastname: Short
authors.forename: D F
authors.initials: DF
authors.lastname: Young
authors.forename: M J
authors.initials: MJ
authors.lastname: Killip
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: S
authors.initials: S
authors.lastname: Goodbourn
authors.forename: R E
authors.initials: RE
authors.lastname: Randall
mesh_terms: D000818:Animals; D002042:Bunyamwera virus / Q000276:immunology / Q000472:pathogenicity*; D045744:Cell Line, Tumor / Q000821:virology; D002522:Chlorocebus aethiops; D054884:Host-Pathogen Interactions; D006801:Humans; D009980:Influenza A virus / Q000276:immunology / Q000472:pathogenicity*; D007370:Interferon Type I / Q000235:genetics / Q000378:metabolism*; D016898:Interferon-alpha / Q000235:genetics / Q000378:metabolism; D016899:Interferon-beta / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000276:immunology / Q000821:virology*; D008168:Lung / Q000166:cytology / Q000276:immunology / Q000821:virology*; D010252:Paramyxoviridae / Q000276:immunology / Q000472:pathogenicity*; D013045:Species Specificity; D014709:Vero Cells / Q000821:virology; D014779:Virus Replication
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; D016899:Interferon-beta