title: Cutoff score of the sexual interest and desire inventory-female for diagnosis of hypoactive sexual desire disorder.
abstract: OBJECTIVE
  To determine the most appropriate cutoff value for the Sexual Interest and Desire Inventory-Female (SIDI-F) score to discriminate between women with hypoactive sexual desire disorder (HSDD) and those with no female sexual dysfunction (FSD). The SIDI-F is a clinician-rated instrument consisting of 13 items designed to assess HSDD severity in women. The total score ranges from 0 to 51, with higher scores indicating better sexual function.
  
  
  METHODS
  Data from patients enrolled in a North American nontreatment study and a European nontreatment study were analyzed. Both studies were 4-week, prospective, multicenter trials designed to assess the reliability and validity of the SIDI-F. Only patients with HSDD or no FSD were included in this analysis. Receiver operating characteristics (ROC) analysis was used to determine the ability of the SIDI-F to differentiate between patients with HSDD and those with no FSD at baseline.
  
  
  RESULTS
  A total of 428 women were included in this analysis: 174 from North America (HSDD 113, no FSD 61) and 254 from Europe (HSDD 130, no FSD 124). In the North American study, a SIDI-F cutoff score of 33 minimized the difference between sensitivity (94.7%) and specificity (93.4%). In the European study, SIDI-F cutoff scores of both 33 and 34 minimized the difference between sensitivity (95.2%) and specificity (94.4%).
  
  
  CONCLUSIONS
  In appropriately screened women, a SIDI-F score of ≤33 indicates the presence of HSDD.
authors.affiliation: Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22903, USA. baydouha@evms.edu
authors.forename: Anita H
authors.initials: AH
authors.lastname: Clayton
authors.forename: Robert T
authors.initials: RT
authors.lastname: Segraves
authors.forename: David
authors.initials: D
authors.lastname: Bakish
authors.forename: David
authors.initials: D
authors.lastname: Goldmeier
authors.forename: Jean
authors.initials: J
authors.lastname: Tignol
authors.forename: Rik H W
authors.initials: RH
authors.lastname: van Lunsen
authors.forename: Rossella E
authors.initials: RE
authors.lastname: Nappi
authors.forename: Glen
authors.initials: G
authors.lastname: Wunderlich
authors.forename: Toshio
authors.initials: T
authors.lastname: Kimura
authors.forename: Diane J
authors.initials: DJ
authors.lastname: Lewis-D'Agostino
authors.forename: Robert
authors.initials: R
authors.lastname: Pyke
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005060:Europe; D005260:Female; D006801:Humans; D007989:Libido / Q000502:physiology; D010555:Personality Inventory; D011446:Prospective Studies; D011594:Psychometrics; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020018:Sexual Dysfunctions, Psychological / Q000175:diagnosis*; D011795:Surveys and Questionnaires; D014481:United States