Granulomatous hepatitis after intravesical bacillus Calmette-Guérin treatment.
A 79-y-old man presented with systemic inflammatory response syndrome (SIRS) and jaundice, 6 h after the first intravesical instillation of bacillus Calmette-Guérin (BCG) for bladder cancer; he had a subsequent reaction 4 weeks later. Liver biopsy findings were compatible with BCG hepatitis. Anti-mycobacterial treatment induced complete recovery. The first episode probably represents a hypersensitivity reaction, whereas the latter course suggests BCG dissemination.
Adami
Maddalena
M
Dipartimento di Medicina Interna, Ospedale Regionale di Lugano, Lugano, Switzerland.
Marsteller
Igor
I
Mazzucchelli
Luca
L
Cerny
Andreas
A
Bernasconi
Enos
E
Bertoli
Raffaela
R
D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D005706:Gallbladder Neoplasms / Q000628:therapy*; D006099:Granuloma / Q000175:diagnosis* / Q000473:pathology; D006505:Hepatitis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000473:pathology; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology
D001500:BCG Vaccine