Study on the Langmuir aggregation of sodium octanesulfonate on human serum albumin.
The microphase adsorption-spectral correction (MPASC) technique was described and applied to the study of the interactions of sodium octanesulfonate (SOS) with human serum albumin (HSA). The aggregation SOS obeys the Langmuir monolayer adsorption. The results show the adsorption ratio of sodium octanesulfonate to HSA is SOS:HSA=18:1.The adsorption constant is K(SOS-HSA)=4.03 × 10(2). The detection limit is 0.036μmol/L. FT-IR spectra proved the binding changed the conformation of HSA.
Li
Ling
L
Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Xueyuan Road 11, Wuchang, Wuhan City, Hubei Province 430062, People's Republic of China. lingli_hubu@yahoo.cn
Xu
Zu Shun
ZS
Song
Gong Wu
GW
D000327:Adsorption; D017738:Alkanesulfonic Acids / Q000737:chemistry*; D006801:Humans; D012709:Serum Albumin / Q000737:chemistry*; D013501:Surface-Active Agents
D017738:Alkanesulfonic Acids; D012709:Serum Albumin; D013501:Surface-Active Agents; C042005:1-octanesulfonic acid