title: A young male heart transplant recipient who developed CKD due to cyclosporine therapy after a decade.
abstract: We report cyclosporine-induced chronic kidney disease (CKD) in a 38year old man who underwent cadaveric orthotopic heart transplant done 13 years ago. He was on triple immuno-suppression including micro-emulsion form of cyclosporine (neoral) with monitoring of his blood cyclosporine levels and serum creatinine. We discuss the pathophysiological mechanisms of cyclosporine toxicity in heart transplant recipients.
authors.affiliation: Madras Medical Mission Hospital, Chennai.
authors.forename: Vaishnavi
authors.initials: V
authors.lastname: Chandramohan
authors.forename: Georgi
authors.initials: G
authors.lastname: Abraham
authors.forename: Milli
authors.initials: M
authors.lastname: Matthew
authors.forename: Ajith
authors.initials: A
authors.lastname: Mullassery
authors.forename: Kanchana
authors.initials: K
authors.lastname: Thirumoorthy
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine