[Correlation of ornidazole concentration in saliva and serum of healthy volunteers].
OBJECTIVE
To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.


METHODS
Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.


RESULTS
The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.


CONCLUSIONS
Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.
Jiang
Yi
Y
Department of Stomatology, General Hospital of PLA, Beijing 100853, China. qtww791001@sohu.com
Liu
Hong-chen
HC
Wu
Xia
X
Feng
Chun-zhen
CZ
Chang
Ping
P
Zhang
Xian-hua
XH
D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009950:Ornidazole / Q000032:analysis / Q000097:blood* / Q000493:pharmacokinetics*; D012463:Saliva / Q000378:metabolism*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D009950:Ornidazole