Neurotrophic keratitis and congenital insensitivity to pain with anhidrosis--a case report with 10-year follow-up.
OBJECTIVE
To report a rare case of congenital insensitivity to pain with anhidrosis.


METHODS
A 3-year-old girl presented with watering in the right eye for 3 days. Slit-lamp examination showed an epithelial defect and hypopyon in the right eye and a corneal scar with thinning and vascularization in the left eye. There was bilateral reduced corneal sensation and evidence of self-mutilated lips and fingers.


RESULTS
Neurological manifestations along with ocular features confirmed the diagnosis of congenital insensitivity to pain with anhidrosis.


CONCLUSIONS
Patients with congenital insensitivity to pain with anhidrosis are asymptomatic even when they develop corneal ulcer. Parents should be advised regular follow-up and prompt treatment because this is a vision-threatening corneal abnormality.
John
Deepa
D
Department of Ophthalmology, Christian Medical College, Vellore, Tamil Nadu, India. deeparebeccajohn@gmail.com
Thomas
Maya
M
Jacob
Pushpa
P
D002675:Child, Preschool; D003241:Consanguinity; D003389:Cranial Nerve Diseases / Q000175:diagnosis* / Q000188:drug therapy; D019573:Epithelium, Corneal / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000188:drug therapy; D009882:Ophthalmic Nerve / Q000473:pathology*; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D012008:Recurrence; D012652:Self Mutilation / Q000175:diagnosis
D009883:Ophthalmic Solutions