title: Successful salvage therapy with inhaled zanamivir in a patient with peramivir-resistant pandemic influenza A (H1N1) 2009 virus.
abstract: We describe a patient with multiple myeloma who developed a pandemic influenza A (H1N1) 2009 virus infection during chemotherapy. The clinical condition of the patient worsened and viral shedding persisted despite 10 days of peramivir treatment; however viral shedding ceased and the patient recovered completely with inhaled zanamivir.
authors.affiliation: Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Ki-Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Sang-Oh
authors.initials: SO
authors.lastname: Lee
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Kim
authors.forename: Je-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Hwajung
authors.initials: H
authors.lastname: Yi
authors.forename: Mi-Seon
authors.initials: MS
authors.lastname: Kim
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Hong
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Woo
authors.forename: Sung-Han
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000146:Acids, Carbocyclic; D000280:Administration, Inhalation; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003517:Cyclopentanes / Q000494:pharmacology; D024882:Drug Resistance, Viral; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome; D017201:Virus Shedding; D053243:Zanamivir / Q000008:administration & dosage*
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D053243:Zanamivir; C414210:peramivir