Pathological aspects of lipid peroxidation.
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
Negre-Salvayre
Anne
A
INSERM I2MR-858, IFR-150, Avenue J Poulhès, BP 84225, Toulouse, France. anne.negre-salvayre@inserm.fr
Auge
Nathalie
N
Ayala
Victoria
V
Basaga
Huveyda
H
Boada
Jordi
J
Brenke
Rainer
R
Chapple
Sarah
S
Cohen
Guy
G
Feher
Janos
J
Grune
Tilman
T
Lengyel
Gabriella
G
Mann
Giovanni E
GE
Pamplona
Reinald
R
Poli
Giuseppe
G
Portero-Otin
Manuel
M
Riahi
Yael
Y
Salvayre
Robert
R
Sasson
Shlomo
S
Serrano
Jose
J
Shamni
Ofer
O
Siems
Werner
W
Siow
Richard C M
RC
Wiswedel
Ingrid
I
Zarkovic
Kamelija
K
Zarkovic
Neven
N
D000375:Aging / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008107:Liver Diseases / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology