title: In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
abstract: LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus.
authors.affiliation: School of Life Science, Handong Global University, Puk-ku, Pohang City, Kyungbuk 791-708, Republic of Korea.
authors.forename: Ji-Woong
authors.initials: JW
authors.lastname: Jeong
authors.forename: Sung-Ji
authors.initials: SJ
authors.lastname: Jung
authors.forename: Hyun-Hee
authors.initials: HH
authors.lastname: Lee
authors.forename: Yong-Zu
authors.initials: YZ
authors.lastname: Kim
authors.forename: Tae-Kyo
authors.initials: TK
authors.lastname: Park
authors.forename: Young-Lag
authors.initials: YL
authors.lastname: Cho
authors.forename: Sang-Eun
authors.initials: SE
authors.lastname: Chae
authors.forename: Sung-Yoon
authors.initials: SY
authors.lastname: Baek
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Woo
authors.forename: Hyang-Sook
authors.initials: HS
authors.lastname: Lee
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Kwak
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000069349:Linezolid; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023303:Oxazolidinones / Q000494:pharmacology* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid