Toll-like receptors: role in dermatological disease.
Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems. Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms. In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics.
Hari
Aswin
A
Immunology Research Group, University of Calgary, Calgary, AB, Canada T2N 4N1. haria@ucalgary.ca
Flach
Tracy L
TL
Shi
Yan
Y
Mydlarski
P Régine
PR
D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D015603:Keratinocytes / Q000378:metabolism; D007801:Langerhans Cells / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism; D008954:Models, Biological; D012871:Skin Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism*
D051193:Toll-Like Receptors