Dendritic cells in tolerance induction for the treatment of autoimmune diseases.
Autoimmune diseases are characterized by the loss of tolerance toward self-antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a non-specific fashion, which is inevitably accompanied by several side effects. Antigen-specific immunomodulation and patient-tailored therapies are likely to solve these issues and to elicit long-term protection against disease flares. This Viewpoint analyzes the potential use of DC for induction of antigen-specific tolerance in autoimmune disease settings.
Rescigno
Maria
M
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. maria.rescigno@ifom-ieo-campus.it
D000818:Animals; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D051379:Mice; D057285:Precision Medicine
D001324:Autoantigens