title: [Current anti-influenza virus chemotherapy].
abstract: The environment surrounding influenza is changing in recent years. In the spring of 2009, pandemic (H1N1) 2009 occurred in Mexico, and became epidemic on a global scale thereafter. Therefore, control of influenza is very important all over the world. Now in Japan, four specific anti-influenza antiviral drugs are available: amantadine, oseltamivir, zanamivir and peramivir. Pandemic (H1N1) 2009 are amantadine-resistant viruses, thus is not recommended for use. Oseltamivir is most commonly used in Japan, however, we have to pay attention to oseltamivir-resistant influenza virus. Almost no zanamivir-resistant influenza virus has been so far reported. In Japan, peramivir is the first drip infusion medicine and is expected to be used in severe cases.
authors.affiliation: Internal Medicine II, Oita University, Faculty of Medicine.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshioka
authors.forename: Issei
authors.initials: I
authors.lastname: Tokimatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
mesh_terms: D000146:Acids, Carbocyclic; D000547:Amantadine / Q000494:pharmacology / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003517:Cyclopentanes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D004363:Drug Utilization / Q000592:standards; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D007262:Infusions, Intravenous; D007564:Japan; D053139:Oseltamivir / Q000494:pharmacology / Q000627:therapeutic use*; D058873:Pandemics; D053243:Zanamivir / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D053139:Oseltamivir; D000547:Amantadine; D053243:Zanamivir; C414210:peramivir