title: Chagas disease and gynecologic neoplasias.
abstract: The inflammation caused by Trypanosoma cruzi produces irritation and cell proliferation and may contribute to the development of cancer. The objective was to determine the occurrence of gynecologic neoplasia (GN) and demographic characteristics in patients with Chagas disease (CD). We used protocols of 671 autopsies between 1976 and 2008. The patients were divided into 3 groups: with GN and CD, only with CD, and only with GN. The 2 diseases were observed in 4.5% of patients with a mean age of 47.6 years and who were predominantly white. The megaesophagus and megacolon were more frequent in the group with only CD. The most common benign neoplasm was uterine leiomyoma, and malignant, carcinoma of the cervix. We conclude that the epidemiological profile of patients with CD and GN was similar to the other groups, and the CD was found not to be a risk factor or protective against the development of GN.
authors.affiliation: Triangulo Mineiro Federal University, Uberaba, Minas Gerais, Brazil.
authors.forename: Venina Marcela
authors.initials: VM
authors.lastname: Dominical
authors.forename: Camila Lourencini
authors.initials: CL
authors.lastname: Cavellani
authors.forename: Laura Penna
authors.initials: LP
authors.lastname: Rocha
authors.forename: Rosana Rosa Miranda
authors.initials: RR
authors.lastname: Corrêa
authors.forename: Gilberto de Araújo
authors.initials: Gde A
authors.lastname: Pereira
authors.forename: Vicente de Paula Antunes
authors.initials: Vde P
authors.lastname: Teixeira
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology*; D014355:Chagas Disease / Q000453:epidemiology / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000453:epidemiology / Q000473:pathology*; D008875:Middle Aged; D014349:Trypanosoma cruzi; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000473:pathology*