The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy.
BACKGROUND
Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The "hypertriglyceridemic waist" phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy.


METHODS
Plasma triglycerides and waist girth were measured at 11-14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24-28 weeks of gestation.


RESULTS
A waist girth greater than 85 cm in combination with a triglyceride level ≥ 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose ≥ 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02).


CONCLUSIONS
Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance.
Brisson
Diane
D
Department of Medicine, Université de Montréal, Montreal, Canada. diane.brisson@ecogene21.org
Perron
Patrice
P
Guay
Simon-Pierre
SP
Gaudet
Daniel
D
Bouchard
Luigi
L
D000293:Adolescent; D000328:Adult; D016640:Diabetes, Gestational / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications; D008423:Maternal Age; D009765:Obesity / Q000150:complications; D010641:Phenotype; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000503:physiopathology; D011261:Pregnancy Trimester, First / Q000378:metabolism / Q000502:physiology; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult