Non-steroidal anti-inflammatory drugs inhibit bone healing: a review.
The ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.
Barry
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Washington State University, Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, PO Box 647060, Pullman, WA 99164-7060, USA. barrys@vetmed.wsu.edu
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001847:Bone Diseases / Q000188:drug therapy / Q000662:veterinary*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D050723:Fractures, Bone / Q000188:drug therapy / Q000662:veterinary*; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats; D013123:Spinal Fusion / Q000379:methods; D014945:Wound Healing / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal