title: Bioactive scaffolds for engineering vascularized cardiac tissues.
abstract: Functional vascularization is a key requirement for the development and function of most tissues, and most critically cardiac muscle. Rapid and irreversible loss of cardiomyocytes during cardiac infarction directly results from the lack of blood supply. Contractile cardiac grafts, engineered using cardiovascular cells in conjunction with biomaterial scaffolds, are an actively studied method for cardiac repair. In this article, we focus on biomaterial scaffolds designed to mediate the development and maturation of vascular networks, by immobilized growth factors. The interactive effects of multiple vasculogenic factors are discussed in the context of cardiac tissue engineering.
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Room 407, Toronto, Ontario, Canada M5S 3G9.
authors.forename: Loraine L Y
authors.initials: LL
authors.lastname: Chiu
authors.forename: Milica
authors.initials: M
authors.lastname: Radisic
authors.forename: Gordana
authors.initials: G
authors.lastname: Vunjak-Novakovic
mesh_terms: D042501:Angiogenic Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D042683:Angiopoietin-1 / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003094:Collagen / Q000737:chemistry; D003331:Coronary Vessels / Q000254:growth & development*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D006493:Heparin / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D055767:Immobilized Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D008863:Microspheres; D009206:Myocardium / Q000166:cytology*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology
chemical_list: D042501:Angiogenic Proteins; D042683:Angiopoietin-1; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D020100:Hydrogels; D055767:Immobilized Proteins; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D006493:Heparin; D003094:Collagen