Molecular mechanisms for plasmacytoid dendritic cell function and development.
Dendritic cells (DCs) are activated by immune adjuvants in a DC subset-specific manner. Plasmacytoid DC (pDC) is a unique subset that senses nucleic acid immune adjuvants only through two Toll-like receptors (TLRs), TLR7 and TLR9 and produces large amounts of type I interferons. Here I review recent trend in pDC function and development.
Kaisho
Tsuneyasu
T
Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. tkaisho@rcai.riken.jp
D000276:Adjuvants, Immunologic / Q000235:genetics; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D007370:Interferon Type I / Q000276:immunology; D051379:Mice; D009696:Nucleic Acids / Q000276:immunology; D015398:Signal Transduction; D051199:Toll-Like Receptor 7 / Q000276:immunology*; D051217:Toll-Like Receptor 9 / Q000276:immunology*
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D009696:Nucleic Acids; D051199:Toll-Like Receptor 7; D051217:Toll-Like Receptor 9