title: Anti-fibrillin-1 autoantibodies in normal pregnancy and recurrent pregnancy loss.
abstract: OBJECTIVE
  The aim of this study was to investigate anti-fibrillin-1 autoantibody in patients with a history of recurrent pregnancy loss (RPL) and during normal pregnancy.
  
  
  METHODS
  Anti-fibrillin-1 IgG and IgM antibodies were measured by a home made ELISA in serum samples of 48 medically and obstetrically normal pregnant women, classified to three trimester groups, 15 female patients with RPL and 26 healthy non-pregnant women classified to two control subgroups: (a) women who had already had at least one previous successful pregnancy and (b) women who had never been pregnant. Differences in anti-fibrillin-1 autoantibodies between the groups were analyzed for statistical significance (P<0.05) with one-way analysis of variance (ANOVA) and multiple comparison test - Post Hoc test, Least Significant Difference method.
  
  
  RESULTS
  Anti-fibrillin-1 IgM autoantibodies were significantly decreased in the second and third trimester pregnant women compared to the nulligravida controls. RPL patients had significantly increased anti-fibrillin-1 IgM antibody compared to control group (a).
  
  
  CONCLUSIONS
  Fibrillin-1 degradation seems to be decreased during the second and third trimester of normal pregnancy. Increased anti-fibrillin-1 IgM antibodies in RPL patients may be a secondary phenomenon of increased fibrillin-1 degradation and contribute to the pathogenesis of pregnancy losses.
authors.affiliation: Department of Biology, Medical University of Pleven, 1, Kliment Ohridski Str., Pleven, 5800, Bulgaria.
authors.forename: Milena Atanasova
authors.initials: MA
authors.lastname: Atanasova
authors.forename: Emiliana Ilieva
authors.initials: EI
authors.lastname: Konova
authors.forename: Tania Ace
authors.initials: TA
authors.lastname: Aleksovska
authors.forename: Katia Nikolova
authors.initials: KN
authors.lastname: Todorova
authors.forename: Miglena Nikolaeva
authors.initials: MN
authors.lastname: Georgieva
authors.forename: Tzvetan Hristoforov
authors.initials: TH
authors.lastname: Lukanov
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D005260:Female; D000071838:Fibrillin-1; D000071837:Fibrillins; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology; D008840:Microfilament Proteins / Q000097:blood* / Q000276:immunology; D011247:Pregnancy / Q000097:blood* / Q000276:immunology; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000276:immunology; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000276:immunology; D054392:Adipokines
chemical_list: D001323:Autoantibodies; D000071838:Fibrillin-1; D000071837:Fibrillins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008840:Microfilament Proteins; C000605722:FBN1 protein, human; D054392:Adipokines