The participation of cytochrome P450 3A4 in clozapine biotransformation is detected in people with schizophrenia by high-throughput in vivo phenotyping.
Ghassabian
Sussan
S
Chetty
Manoranjenni
M
Tattam
Bruce N
BN
Glen
John
J
Rahme
Jeannie
J
Stankovic
Zvijezdana
Z
Ramzan
Iqbal
I
Murray
Michael
M
McLachlan
Andrew J
AJ
D001711:Biotransformation; D003024:Clozapine / Q000378:metabolism* / Q000627:therapeutic use; D051544:Cytochrome P-450 CYP3A / Q000235:genetics* / Q000502:physiology; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D010641:Phenotype; D011446:Prospective Studies; D012559:Schizophrenia / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics*
D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D003024:Clozapine