Multicentric castleman disease in a child with primary immunodeficiency.
Multicentric Castleman disease is a rare lymphoproliferative disorder mostly seen in adults with HIV. It presents with fever and systemic symptoms and is extremely uncommon in children. We describe a novel case of multicentric Castleman disease associated with primary immunodeficiency (common variable immunodeficiency) and discuss pathophysiologic mechanisms and recent advances in understanding this disease.
Drolet
Jean-Philippe
JP
Division of Allergy and Clinical Immunology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
Lefebvre
Marie-Astrid
MA
Bernard
Chantal
C
Mitchell
David
D
McCusker
Christine
C
Mazer
Bruce
B
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005871:Castleman Disease / Q000188:drug therapy* / Q000209:etiology* / Q000821:virology; D002648:Child; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D011379:Prognosis
D000893:Anti-Inflammatory Agents; D011241:Prednisone