Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta by GC-MS and their cholinesterase activity.
From the bulbs of Zephyranthes robusta Baker (Amaryllidaceae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC50 = 35.9 +/- 3.5 microg/mL) and HuBuChE (IC50 = 190.9 +/- 8.2 microg/mL).
Cahlíková
Lucie
L
Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@faf.cuni.cz
Kulhánková
Andrea
A
Urbanová
Klára
K
Valterová
Irena
I
Macáková
Katerina
K
Kunes
Jirí
J
D047151:Amaryllidaceae Alkaloids / Q000032:analysis* / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*
D047151:Amaryllidaceae Alkaloids; D002800:Cholinesterase Inhibitors; D002091:Butyrylcholinesterase