title: Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis.
abstract: The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patients who had undergone hysterectomies for adenomyosis. Immunohistochemistry with antibodies against NGF, NGFR p75, and TrkA, was performed. The expression of NGF, NGFR p75, and TrkA in endometrium and myometrium of LNG-IUS-treated patients was significantly decreased compared to those of hormonally untreated patients. Our findings may indicate that the suppression of NGF and its receptors by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis.
authors.affiliation: Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Shinchon-dong, Seodaemun-gu, Seoul, South Korea.
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Choi
authors.forename: Sihyun
authors.initials: S
authors.lastname: Cho
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lim
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Jeon
authors.forename: Hyo In
authors.initials: HI
authors.lastname: Yang
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Kamdar
authors.initials: K
authors.lastname: Heena
authors.forename: Seok Kyo
authors.initials: SK
authors.lastname: Seo
authors.forename: Hye Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000328:Adult; D004412:Dysmenorrhea / Q000188:drug therapy; D004715:Endometriosis / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: D017475:Receptors, Nerve Growth Factor; D016912:Levonorgestrel; D020932:Nerve Growth Factor