title: Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin.
abstract: OBJECTIVE
  Bone marrow mesenchymal stromal cell (BMStC) transplantation into the infarcted heart improves left ventricular function and cardiac remodelling. However, it has been suggested that tissue-specific cells may be better for cardiac repair than cells from other sources. The objective of the present work has been the comparison of in vitro and in vivo properties of adult human cardiac stromal cells (CStC) to those of syngeneic BMStC.
  
  
  RESULTS
  Although CStC and BMStC exhibited a similar immunophenotype, their gene, microRNA, and protein expression profiles were remarkably different. Biologically, CStC, compared with BMStC, were less competent in acquiring the adipogenic and osteogenic phenotype but more efficiently expressed cardiovascular markers. When injected into the heart, in rat a model of chronic myocardial infarction, CStC persisted longer within the tissue, migrated into the scar, and differentiated into adult cardiomyocytes better than BMStC.
  
  
  CONCLUSIONS
  Our findings demonstrate that although CStC and BMStC share a common stromal phenotype, CStC present cardiovascular-associated features and may represent an important cell source for more efficient cardiac repair.
authors.affiliation: Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, IRCCS, Milano, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rossini
authors.forename: Caterina
authors.initials: C
authors.lastname: Frati
authors.forename: Costanza
authors.initials: C
authors.lastname: Lagrasta
authors.forename: Gallia
authors.initials: G
authors.lastname: Graiani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Scopece
authors.forename: Stefano
authors.initials: S
authors.lastname: Cavalli
authors.forename: Ezio
authors.initials: E
authors.lastname: Musso
authors.forename: Marco
authors.initials: M
authors.lastname: Baccarin
authors.forename: Marina
authors.initials: M
authors.lastname: Di Segni
authors.forename: Francesco
authors.initials: F
authors.lastname: Fagnoni
authors.forename: Antonia
authors.initials: A
authors.lastname: Germani
authors.forename: Eugenio
authors.initials: E
authors.lastname: Quaini
authors.forename: Manuel
authors.initials: M
authors.lastname: Mayr
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Xu
authors.forename: Andrea
authors.initials: A
authors.lastname: Barbuti
authors.forename: Dario
authors.initials: D
authors.lastname: DiFrancesco
authors.forename: Giulio
authors.initials: G
authors.lastname: Pompilio
authors.forename: Federico
authors.initials: F
authors.lastname: Quaini
authors.forename: Carlo
authors.initials: C
authors.lastname: Gaetano
authors.forename: Maurizio C
authors.initials: MC
authors.lastname: Capogrossi
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology; D002459:Cell Fusion; D019070:Cell Lineage / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000166:cytology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000166:cytology*
chemical_list: D015415:Biomarkers