title: Subclinical candiduria in patients with gastrointestinal malignancies: a preliminary study on the protective effect of a natural phytocompound.
abstract: There is a great concern for the increasing incidence of candidiasis in cancer patients following immune-suppressive, cytostatic or antibiotic treatment. There are cancer patients with repeat asymptomatic recovery of candida in the urine in whom the choice of treatment, if any, is still a matter of debate. The aim of the study is to test the efficacy and tolerability of a natural anti-fungal phytocompound in patients with tumors of the gastrointestinal tract with prior or ongoing candiduria. Thirty-nine patients with operated gastrointestinal malignancies (18 still under current chemotherapy) with a history of repeated candiduria were enrolled. Eleven patients showed candiduria on enrolment and were treated with K-712, a natural antifungal phytocompound. Genomic analysis was carried out on blood samples of all patients on a monthly basis for 6 months. Within 3 weeks all 11 treated patients had negative cultures in the urine (10 patients after 2 weeks), 7 patients remained free of candiduria throughout the study period while 4 required a new treatment course. Three patients had positive genomic tests for systemic candidiasis and were treated with fluconazole. Eighteen (64 percent) out of the 28 patients who were free of candiduria on enrolment, developed a urinary candida infection during the 6-month follow-up and all cases were successfully treated with K-712. Seven (38 percent) of these cases presented a further recurrence at a later stage and all responded to a new course of K-172. No positive genomic tests were observed during the follow-up period. These data suggest that a consistent part of patients, mostly with gastrointestinal malignancies develop urinary candida infection when following chemotherapy treatment. A therapeutic approach with a natural antifungal phytocompound seems a safe and effective measure and a tentative prophylactic approach might also be envisaged.
authors.affiliation: Immunology Research Institute and Clinic, Nagoya, Japan. fmarchimede@libero.it
authors.forename: F
authors.initials: F
authors.lastname: Marotta
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: M P
authors.initials: MP
authors.lastname: Bishier
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: H
authors.initials: H
authors.lastname: Yadav
authors.forename: E
authors.initials: E
authors.lastname: Minelli
authors.forename: A
authors.initials: A
authors.lastname: Kumari
authors.forename: U
authors.initials: U
authors.lastname: Solimene
authors.forename: J
authors.initials: J
authors.lastname: Sollano
mesh_terms: D000368:Aged; D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D028042:Pimpinella; D032425:Pseudowintera; D014552:Urinary Tract Infections / Q000188:drug therapy*; D014556:Urine / Q000382:microbiology