Genistein attenuates low temperature induced pulmonary hypertension in broiler chicks by modulating endothelial function.
Pulmonary arterial hypertension is characterized by high pulmonary blood pressure, vascular remodeling and right ventricular hypertrophy. In the present study, we investigated whether genistein would prevent the development of low temperature-induced pulmonary hypertension in broilers. Hemodynamic parameters, vascular remodeling, the expression of endothelial nitric oxide and endothelin-1 content in lung tissue were evaluated. The results demonstrated that genistein significantly reduced pulmonary arterial hypertension and suppressed pulmonary arterial vascular remodeling without affecting broilers' performance. The beneficial effects appeared to be mediated by restoring endothelial function especially endothelial nitric oxide and endothelin-1, two critical vasoactive molecules that associated with the development of hypertension. Genistein supplementation might be a potential therapeutic strategy for the treatment of pulmonary hypertension.
Yang
Ying
Y
State Key Lab of Animal Nutrition, College of Animal Science and Technology, China Agricultural University (CAU), Beijing, 100193, PR China.
Gao
Mingyu
M
Wu
Zhenlong
Z
Guo
Yuming
Y
D000818:Animals; D001201:Ascites / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary; D002645:Chickens / Q000254:growth & development; D003080:Cold Temperature / Q000009:adverse effects; D006152:Cyclic GMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D019833:Genistein / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006976:Hypertension, Pulmonary / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D008168:Lung / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D008297:Male; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010490:Pericardial Effusion / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D048789:Phytoestrogens / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D015430:Weight Gain / Q000187:drug effects
D019332:Endothelin-1; D048789:Phytoestrogens; D019833:Genistein; D052250:Nitric Oxide Synthase Type III; D006152:Cyclic GMP