title: Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes.
abstract: We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.
authors.affiliation: Nanomedicine Laboratory, Centre for Drug Delivery, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Van den Bossche
authors.forename: Wafa' T
authors.initials: WT
authors.lastname: Al-Jamal
authors.forename: Bowen
authors.initials: B
authors.lastname: Tian
authors.forename: Antonio
authors.initials: A
authors.lastname: Nunes
authors.forename: Chiara
authors.initials: C
authors.lastname: Fabbro
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
authors.forename: Maurizio
authors.initials: M
authors.lastname: Prato
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostarelos
mesh_terms: D052157:Aptamers, Nucleotide; D001483:Base Sequence; D001692:Biological Transport; D045744:Cell Line, Tumor; D017931:DNA Primers; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon; D011956:Receptors, Cell Surface / Q000502:physiology*
chemical_list: D052157:Aptamers, Nucleotide; D017931:DNA Primers; D037742:Nanotubes, Carbon; D011956:Receptors, Cell Surface