title: [The expression of human major histocompatibility complex-I in oral leukoplakia].
abstract: OBJECTIVE
  The purpose of this study was to examine the expression of human major histocompatibility complex-I at different degrees of dysplasia leukoplakia, and to investigate local immune status and discuss their associations with oral leukoplakia.
  
  
  METHODS
  The monoclonal antibody of MHC class I antigen was employed in this study. There were 55 oral leukoplakias, 31 primary oral squamous cell carcinomas and 28 histologically normal oral epithelia were detected for the presence of the MHC class I molecule by using immunohistochemistry method.
  
  
  RESULTS
  The MHC class I antigen expression of the severe dysplasia and oral squamous cell carcinoma was significantly lower than that of the normal epithelia (P < 0.05). But their expression did not show statistically difference between the normal epithelia and other groups of oral leukoplakia (P > 0.05).
  
  
  CONCLUSIONS
  The expression levels of the MHC class I antigen is reduced in oral leukoplakia, particularly in severe dysplasia oral leukoplakia, it is relevant to the degree of dysplasia.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Ping-Fan
authors.initials: PF
authors.lastname: Wu
authors.forename: Bang-feng
authors.initials: BF
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Xia
authors.forename: Chao-ran
authors.initials: CR
authors.lastname: Yan
authors.forename: Long-jiang
authors.initials: LJ
authors.lastname: Li
mesh_terms: D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics
chemical_list: D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I