[Effect of physical activity and t-786C polymorphism in blood pressure and blood flow in the elderly].
BACKGROUND
the T-786C polymorphism of the gene for endothelial nitric oxide synthase (eNOS) and superoxide anion production may reduce production and bioavailability of nitric oxide, affecting the degree of vasodilation. This effect can be reversed by exercise.


OBJECTIVE
to investigate the influence of aerobic training and T-786C polymorphism in the concentrations of nitric oxide metabolites (NOx) in blood flow (BF) and blood pressure (BP).


METHODS
thirty-two elderly pre-hypertensive women (59 ± 6 years old) were divided into two groups according to the T-786C polymorphism (TT and TC + CC). We analyzed the concentrations of NOx (plasma) and blood flow by venous occlusion plethysmography at rest, 1, 2 and 3 minutes post-occlusion (BF-0, BF-1 BF-2 BF-3, respectively). Evaluations were performed before and after 6 months of a program of aerobic exercise.


RESULTS
In the pre-training evaluations, NOx levels were lower in TC + CC group than in TT group. The TT group showed correlations between NOx and BF-0 (r = 0.6) and diastolic blood pressure (DBP) and BF-0 (r = -0.7), but no correlation was found in TC + CC group. In the post-training evaluations, there were correlations between NOx and BF-0 (r = 0.6) and the changes in NOx and DBP (r = -0.6) in TT group. There were also correlations between DBP and BF-1 (r = -0.8), DBP, and BF-2 (r = -0.6), DBP, and BF-3 (r = -0.6), in the changes between NOx and BF-1 (r = 0.8) and changes in NOx and DBP (r = -0.7) in TC + CC group.


CONCLUSIONS
it was concluded that 6 months of aerobic exercise can increase the relationship between NO, BP and BF in elderly of allele C carriers.
Zago
Anderson Saranz
AS
Escola de Educação Física e Esportes, USP, Ribeirão Preto, SP, Brasil. azzago@usp.br
Kokubun
Eduardo
E
Fenty-Stewart
Nicola
N
Park
Joon-Young
JY
Attipoe
Selasi
S
Hagberg
James
J
Brown
Michael
M
D000368:Aged; D000704:Analysis of Variance; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity / Q000235:genetics / Q000502:physiology*; D009569:Nitric Oxide / Q000097:blood*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics / Q000502:physiology
D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D013482:Superoxide Dismutase