Delivering a hydrophobic anticancer drug for photodynamic therapy by amorphous formulation.
An amorphous formulation of hypocrellin A for photodynamic therapy is reported which can provide stable aqueous dispersion of such hydrophobic photosensitizers. In vitro studies have demonstrated the active uptake of amorphous formulation of hypocrellin A into the mitochondria of tumor cells. Compared with Tween-80 micelle embedded hypocrellin A, low dark-toxicity but similar light-toxicity of the amorphous one to drug impregnated tumor cells was observed. Thus, the potential of using amorphous formulation of hypocrellin A as drug delivery system for photodynamic therapy has been demonstrated.
Zhou
Lin
L
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 211198, China.
Wang
Wei
W
Feng
Yuying
Y
Wei
Shaohua
S
Zhou
Jiahong
J
Yu
Boyang
B
Shen
Jian
J
D001562:Benzimidazoles; D016923:Cell Death; D002626:Chemistry, Pharmaceutical; D004396:Coloring Agents; D004272:DNA, Mitochondrial / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D008928:Mitochondria / Q000378:metabolism; D010569:Perylene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D019800:Phenol; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D011136:Polysorbates; D011809:Quinones / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D013050:Spectrometry, Fluorescence; D013501:Surface-Active Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D014961:X-Ray Diffraction
D001562:Benzimidazoles; D004396:Coloring Agents; D004272:DNA, Mitochondrial; D005456:Fluorescent Dyes; D008823:Micelles; D017319:Photosensitizing Agents; D011136:Polysorbates; D011809:Quinones; D013501:Surface-Active Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D019800:Phenol; D010569:Perylene; C022616:thiazolyl blue; C017807:bisbenzimide ethoxide trihydrochloride; C048388:hypocrellin A