Protective effects of Danshensu on liver injury induced by omethoate in rats.
This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate aminotransferase, alanine aminotransferase, cyclooxygenase-2, tumor necrosis factor-alpha, thromboxane B(2), and thromboxane B(2)/6-keto-PGF1alpha ratio induced by omethoate. The histopathological examination further confirmed that administration with Denshensu ameliorated liver injury. The results demonstrated that Danshensu possesses protective action on hepatic injury induced by omethoate and the pharmacological mechanism was related to the anti-inflammatory effect and circulation improvement of Danshensu, at least in part.
Ren
Rutong
R
Department of Pharmacology, School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai, ShanDong 264005, PR China.
Wang
Tian
T
Jiang
Na
N
Liu
Tongshen
T
Du
Yuan
Y
Li
Chong
C
Zhang
Leiming
L
Fu
Fenghua
F
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D018890:Chemoprevention; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004117:Dimethoate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007773:Lactates / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013929:Thromboxane B2 / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D007773:Lactates; D014409:Tumor Necrosis Factor-alpha; C002302:dimethoxon; C035055:3,4-dihydroxyphenyllactic acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D051546:Cyclooxygenase 2; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D004117:Dimethoate