Macrophage-dominant sialadenitis in human T-cell leukemia virus type I-associated myelopathy after living-donor liver transplantation.
A 64-year-old man who suffered from human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (HAM) after living-donor liver transplantation (LDLT) for liver cirrhosis due to hepatitis C virus infection complained of xerostomia. Although exocrine function test results were positive, autoantibodies including anti-SS-A/SS-B antibodies and sialography showed negative findings. Labial salivary gland biopsy revealing infiltration of 60 counts of mononuclear cells (MNCs) in minor salivary glands led to a diagnosis of Sjögren's syndrome-like sialadenitis. Immunohistochemistry demonstrated dominant CD68 staining and major histocompatibility complex class II on the surface of infiltrating MNCs. Herein we have reported a rare condition of macrophage-dominant sialadenitis in a patient with HAM after LDLT.
Nakamura
H
H
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. nakamura_hideki911@yahoo.co.jp
Ichikawa
T
T
Nakamura
T
T
Kawakami
A
A
Iwamoto
N
N
Matsuzaki
T
T
Miyaaki
H
H
Yamasaki
S
S
Ida
H
H
Eguchi
S
S
Hayashi
T
T
Nakao
K
K
Kanematsu
T
T
Eguchi
K
K
D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000627:therapeutic use; D012793:Sialadenitis / Q000209:etiology* / Q000473:pathology
D000998:Antiviral Agents; D007074:Immunoglobulin G; D012254:Ribavirin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase