title: [Two cases of colorectal cancer presenting with periodic, transient elevation of serum iron due to hemolysis after chemotherapy including 5-FU].
abstract: The serum iron level reportedly shows transient elevation after chemotherapy in some cases. However, the cause of this phenomenon has not been clearly described. We report two cases of colorectal cancer whose serum iron level demonstrated recurrent elevation after chemotherapy. Both were advanced colorectal cancer cases with liver metastases, so we started chemotherapy with modified FOLFOX6+bevacizumab. After several courses, we changed the regimen to simplified LV5FU2+ bevacizumab in both cases. The serum iron level showed transient, periodical elevation irrespective of the therapeutic regimen. Additionally, indirect bilirubin also showed transient elevation, which was completely synchronized with the fluctuation of the serum iron level. These observations suggest that hemolysis is the main cause of periodic, transient elevation of serum iron level after chemotherapy including 5-FU.
authors.affiliation: Dept. of Laboratory Medicine, Kaken Hospital, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Motoori
authors.forename: Tomoe
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Nozomi
authors.initials: N
authors.lastname: Iwamoto
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kase
authors.forename: Naoko
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Saisho
authors.forename: Junji
authors.initials: J
authors.lastname: Furuse
authors.forename: Masayuki
authors.initials: M
authors.lastname: Itabashi
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006461:Hemolysis; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy*
chemical_list: D007501:Iron; D001663:Bilirubin; D005472:Fluorouracil