Modeling disease progression in acute stroke using clinical assessment scales.
This article demonstrates techniques for describing and predicting disease progression in acute stroke by modeling scores measured using clinical assessment scales, accommodating dropout as an additional source of information. Scores assessed using the National Institutes of Health Stroke Scale and the Barthel Index in acute stroke patients were used to model the time course of disease progression. Simultaneous continuous and probabilistic models for describing the nature and magnitude of score changes were developed, and used to model the trajectory of disease progression using scale scores. The models described the observed data well, and exhibited good simulation properties. Applications include longitudinal analysis of stroke scale data, clinical trial simulation, and prognostic forecasting. Based upon experience in other areas, it is likely that application of this modeling methodology will enable reductions in the number of patients needed to carry out clinical studies of treatments for acute stroke.
Karlsson
Kristin E
KE
Department of Pharmaceutical Biosciences, Uppsala University, Sweden. kristin.karlsson@farmbio.uu.se
Wilkins
Justin J
JJ
Jonsson
Fredrik
F
Zingmark
Per-Henrik
PH
Karlsson
Mats O
MO
Jonsson
E Niclas
EN
D000208:Acute Disease; D018450:Disease Progression; D006801:Humans; D008962:Models, Theoretical; D020521:Stroke / Q000503:physiopathology*