title: C28 sterols with a cyclopentane ring at C-22 and 26 from cape gooseberry (berries of Physalis pubeacens L.).
abstract: Two new C28 sterols with a cyclopentane ring at C-22 and 26, alkesterol A (1) and alkesterol B (2), along with β-sitosterol (3), were isolated from the berries of Physalis pubeacens L. (cape gooseberry). The structures of the new compounds were established by HR-EI-MS, 1D and 2D (1H-1H COSY, HSQC, HMBC) NMR experiments. The known compound was identified by comparison of spectral data with published references. The two new compounds showed some cytotoxic activities by MTT assay.
authors.affiliation: College of Pharmacy, Soochow University, Suzhou, China.
authors.forename: Qiong-Ming
authors.initials: QM
authors.lastname: Xu
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
authors.forename: Xiao-Ran
authors.initials: XR
authors.lastname: Li
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D031965:Ribes / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010840:Phytosterols; C552637:alkesterol A; C552638:alkesterol B