Site-specific photochemical RNA editing.
Photo-induced artificial RNA editing was demonstrated using photo-reactive oligonucleotides containing 3-cyanovinylcarbazole nucleoside. This non-enzymatic and sequence-specific methodology will make a major contribution to the elucidation of RNA functions including non-coding RNAs and to the development of drugs based on sequence-specific RNA editing.
Fujimoto
Kenzo
K
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa, 923-1292, Japan. kenzo@jaist.ac.jp
Konishi-Hiratsuka
Kaoru
K
Sakamoto
Takashi
T
Yoshimura
Yoshinaga
Y
D001483:Base Sequence; D002227:Carbazoles / Q000737:chemistry; D003596:Cytosine / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D010777:Photochemistry / Q000379:methods*; D012313:RNA / Q000737:chemistry*; D017393:RNA Editing; D014498:Uracil / Q000737:chemistry*
D002227:Carbazoles; D009705:Nucleosides; D009841:Oligonucleotides; D014498:Uracil; D012313:RNA; D003596:Cytosine