Clinical significance of early-onset hyperuricemia in renal transplant recipients.
OBJECTIVE
It is undetermined whether the effect of uric acid (UA) on graft outcome is independent of graft dysfunction. This study was designed to explore whether early-onset hyperuricemia has clinical significance regardless of graft function.


METHODS
This study was conducted based on a retrospective chart review. We calculated time-averaged UA and estimated glomerular filtration rate from the values at 3, 6, and 9 months after transplantation. Cardiovascular complications during follow-up and long-term graft survival were assessed according to UA levels and graft function.


RESULTS
351 patients were enrolled into this study. Hyperuricemia increased the risk of cardiovascular complications (HR = 2.8, 95% CI 1.1-7.1; p = 0.02), but reduced graft function did not. In the hyperuricemia group, 5- and 10-year graft survival was significantly lower than in the normouricemia group (89 and 81% vs. 96 and 92%, respectively; p = 0.02). In the reduced graft function group, these values were also lower than in the normal graft function group (89 and 81% vs. 96 and 93%, respectively; p = 0.02). In the multivariate analysis, both hyperuricemia and reduced graft function were independent risk factors for graft failure and the presence of both factors presented the highest risk.


CONCLUSIONS
Early-onset hyperuricemia is a significant predictor of cardiovascular complications and graft survival independently of graft function.
Chung
Byung Ha
BH
Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kang
Seok Hui
SH
Hwang
Hyeon Seok
HS
Choi
Bum Soon
BS
Park
Cheol Whee
CW
Kim
Yong-Soo
YS
Kim
Ji-Il
JI
Moon
In Sung
IS
Yang
Chul Woo
CW
D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid