title: Plasma levels of MCP-1 and adiponectin in obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  To evaluate the correlation between concentrations of the proinflammatory cytokines monocyte chemotactic protein 1 (MCP-1), adiponectin, interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor (TNF) and patients with obstructive sleep apnea syndrome (OSAS). Repeated apnea attacks in patients with OSAS constitute a hypoxic condition, which induces tissue inflammation by mediation of these proinflammatory cytokines.
  
  
  METHODS
  Radioimmunoassay analyses of nonrandomized controlled trial.
  
  
  METHODS
  University-affiliated tertiary care hospital.
  
  
  METHODS
  The study population comprised 59 patients who underwent the polysomnography.
  
  
  METHODS
  Serum concentrations of MCP-1, adiponectin, IL-6, IL-8, and TNF, as well as body mass index and polysomnographic data, including apnea-hypopnea index (AHI) and lowest oxygen saturation.
  
  
  RESULTS
  The mean (SD) plasma level of MCP-1 in serum was increased in all patients with OSAS (P < .001), while adiponectin level was decreased in the patients with severe OSAS (6.88 [1.78] μg/mL) compared with normal controls (8.90 [2.63] μg/mL) (P = .006). Serum concentrations of IL-6, IL-8, and TNF did not exhibit any differences between patients with OSAS and normal controls. The correlation coefficient between plasma MCP-1 level and AHI was 0.62 and between adiponectin level and AHI was 0.66.
  
  
  CONCLUSIONS
  Our results suggest that plasma MCP-1 and adiponectin levels were different between patients with OSAS and normal controls. Adiponectin and MCP-1 may be prognostic factors for comparing patients with OSAS before and after treatment.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Yeongdeungpo-gu, Seoul 150-713, Korea.
authors.forename: Joohwan
authors.initials: J
authors.lastname: Kim
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Lee
authors.forename: Chan Soon
authors.initials: CS
authors.lastname: Park
authors.forename: Byung Guk
authors.initials: BG
authors.lastname: Kim
authors.forename: Soo Whan
authors.initials: SW
authors.lastname: Kim
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Cho
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D017286:Polysomnography; D011863:Radioimmunoassay; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D018932:Chemokine CCL2; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha