Arterial stiffness, lipoprotein particle size, and lipoprotein particle concentration in children with type 1 diabetes.
OBJECTIVE
To determine if lipoprotein particle abnormalities correlate with arterial stiffness in children with type 1 diabetes (T1D).


METHODS
In this case-control study, we evaluated 70 children, 35 with T1D and 35 controls, ages 10-18 years, matched for age, sex, race, and BMI. Arterial stiffness was assessed by radial tonometry (AI75) and blood was collected for lipoprotein subclass analysis.


RESULTS
T1D subjects had increased AI75, decreased small LDL particle concentration (P = 0.0067), increased large LDL particle concentration (P = 0.007), increased large HDL particle concentration (P = 0.0012), increased mean LDL particle size (P = 0.0028), and increased mean HDL particle size (P < 0.0001) compared to controls. No significant correlations were found between lipoprotein subclasses and arterial stiffness in T1D subjects.


CONCLUSIONS
T1D subjects have increased arterial stiffness when compared to controls, despite a less pro-atherogenic lipoprotein profile, indicating the need to identify other risk factors that correlate with arterial stiffness in T1D youth.
Gallo
Lisa M
LM
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.
Silverstein
Janet H
JH
Shuster
Jonathan J
JJ
Haller
Michael J
MJ
D000293:Adolescent; D001158:Arteries / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010316:Particle Size; D012307:Risk Factors
D006442:Glycated Hemoglobin; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; C517652:hemoglobin A1c protein, human