title: Strong association between a new marker of hemolysis and glomerulopathy in sickle cell anemia.
abstract: To perform a precise evaluation of the hemolytic status of patients with sickle cell anemia (SCA), advanced red blood cell parameters provided by the last generation analyzers were investigated in a series of SCA patients. The search for precise markers of hemolysis was performed to identify if patients so exposed develop organic complications related to a postulated hemolysis-linked endothelial dysfunction. Red blood cell survival was evaluated by the ratio between mature red blood cell (RBC) and reticulocyte (RET) hemoglobin (RBC-Hb/RET-Hb). In comparison with serum lactate dehydrogenase (LDH) and total bilirubin, the log (RBC-Hb/RET-Hb) was identified as the most discriminant hematological parameter to evaluate hemolysis. Furthermore, by combining this parameter with LDH, we defined a composite variable, which we called CVar, that is highly correlated with albuminuria and might constitute a powerful new marker of risk for this complication.
authors.affiliation: Service d'Hématologie Biologique, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, F-75020, Paris, France. micheline.maier@tnn.aphp.fr
authors.forename: Micheline
authors.initials: M
authors.lastname: Maier-Redelsperger
authors.forename: Pierre
authors.initials: P
authors.lastname: Lévy
authors.forename: François
authors.initials: F
authors.lastname: Lionnet
authors.forename: Katia
authors.initials: K
authors.lastname: Stankovic
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Haymann
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lefèvre
authors.forename: Virginie
authors.initials: V
authors.lastname: Avellino
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Perol
authors.forename: Robert
authors.initials: R
authors.lastname: Girot
authors.forename: Jacques
authors.initials: J
authors.lastname: Elion
mesh_terms: D000419:Albuminuria / Q000175:diagnosis*; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications*; D015415:Biomarkers; D002470:Cell Survival; D004912:Erythrocytes / Q000473:pathology; D005921:Glomerulonephritis / Q000175:diagnosis*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D012156:Reticulocytes / Q000473:pathology
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase