Inflammatory bowel disease and completed suicide in Danish adults.
BACKGROUND
The risk of suicide is increased among people with inflammatory bowel disease (IBD); however, most of the evidence regarding this association comes from studies of all-cause mortality, with small numbers of people who have committed suicide, or from clinical case reports. The current study examined the association between the two forms of IBD: Crohn's disease (CD) and ulcerative colitis (UC), and completed suicide in a population-based sample.


METHODS
Data for this nested case-control study were obtained from the Danish national healthcare and social registries. We included 27,053 cases who completed suicide between January 1, 1981, and December 31, 2006. Controls were selected from the general population and matched to cases on gender, date of birth, and calendar time (n = 551,060).


RESULTS
There was an increased rate of suicide among participants with both CD (odds ratio [OR] = 1.6, 95% confidence interval [CI]: 1.1, 2.3) and UC (OR = 1.9, 95% CI: 1.4, 2.4), when adjusting for the matched factors and identified confounders.


CONCLUSIONS
The current study suggests that physicians treating IBD patients should be vigilant about expressions of suicidal ideation or signs and symptoms of self-harm.
Gradus
Jaimie L
JL
National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts 02130, USA. Jaimie.Gradus@va.gov
Qin
Ping
P
Lincoln
Alisa K
AK
Miller
Matthew
M
Lawler
Elizabeth
E
Sørensen
Henrik Toft
HT
Lash
Timothy L
TL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000523:psychology*; D008297:Male; D001523:Mental Disorders; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012042:Registries; D012307:Risk Factors; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D055815:Young Adult