title: Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: an outcomes study from the Pediatric Cardiomyopathy Registry.
abstract: BACKGROUND
  Myocarditis is a cause of a new-onset dilated cardiomyopathy phenotype in children, with small studies reporting high rates of recovery of left ventricular (LV) function.
  
  
  RESULTS
  The presenting characteristics and outcomes of children with myocarditis diagnosed clinically and with biopsy confirmation (n=119) or with probable myocarditis diagnosed clinically or by biopsy alone (n=253) were compared with children with idiopathic dilated cardiomyopathy (n=1123). Characteristics at presentation were assessed as possible predictors of outcomes. The distributions of time to death, transplantation, and echocardiographic normalization in the biopsy-confirmed myocarditis and probable myocarditis groups did not differ (P≥0.5), but both groups differed significantly from the idiopathic dilated cardiomyopathy group (all P≤0.003). In children with myocarditis, lower LV fractional shortening z-score at presentation predicted greater mortality (hazard ratio, 0.85; 95% confidence interval, 0.73 to 0.98; P=0.03) and greater LV posterior wall thickness predicted transplantation (hazard ratio, 1.17; 95% confidence interval, 1.02 to 1.35; P=0.03). In those with decreased LV fractional shortening at presentation, independent predictors of echocardiographic normalization were presentation with an LV end-diastolic dimension z-score >2 (hazard ratio, 0.36; 95% confidence interval, 0.22 to 0.58; P<0.001) and greater septal wall thickness (hazard ratio, 1.16; 95% confidence interval, 1.01 to 1.34; P=0.04).
  
  
  CONCLUSIONS
  Children with biopsy-confirmed or probable myocarditis had similar proportions of death, transplantation, and echocardiographic normalization 3 years after presentation and better outcomes than those of children with idiopathic dilated cardiomyopathy. In children with myocarditis who had impaired LV ejection at presentation, rates of echocardiographic normalization were greater in those without LV dilation and in those with greater septal wall thickness at presentation. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00005391.
authors.affiliation: Washington University at St Louis, 1 Children’s Place, St Louis, MO 63110, USA. susanfoerster@msn.com
authors.forename: Susan R
authors.initials: SR
authors.lastname: Foerster
authors.forename: Charles E
authors.initials: CE
authors.lastname: Canter
authors.forename: Amy
authors.initials: A
authors.lastname: Cinar
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Sleeper
authors.forename: Steven A
authors.initials: SA
authors.lastname: Webber
authors.forename: Elfriede
authors.initials: E
authors.lastname: Pahl
authors.forename: Paul F
authors.initials: PF
authors.lastname: Kantor
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Alvarez
authors.forename: Steven D
authors.initials: SD
authors.lastname: Colan
authors.forename: John L
authors.initials: JL
authors.lastname: Jefferies
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Lamour
authors.forename: Renee
authors.initials: R
authors.lastname: Margossian
authors.forename: Jane E
authors.initials: JE
authors.lastname: Messere
authors.forename: Paolo G
authors.initials: PG
authors.lastname: Rusconi
authors.forename: Robert E
authors.initials: RE
authors.lastname: Shaddy
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Towbin
authors.forename: James D
authors.initials: JD
authors.lastname: Wilkinson
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lipshultz
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000401:mortality* / Q000503:physiopathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009205:Myocarditis / Q000000981:diagnostic imaging / Q000401:mortality* / Q000503:physiopathology* / Q000601:surgery; D012042:Registries; D012189:Retrospective Studies; D013318:Stroke Volume; D013534:Survival; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling