Temporo-parietal junction stimulation in the treatment of depersonalization disorder.
This is the first clinical trial of repetitive Transcranial Magnetic Stimulation (rTMS) in depersonalization disorder (DPD). After 3weeks of right temporo-parietal junction (TPJ) rTMS, 6/12 patients responded. Five responders received 3 more weeks of right TPJ rTMS showing 68% DPD symptoms improvement. Right TPJ rTMS was safe and effective.
Mantovani
Antonio
A
Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University/New York State Psychiatric Institute, New York 10032, USA. am2518@columbia.edu
Simeon
Daphne
D
Urban
Nina
N
Bulow
Peter
P
Allart
Anouk
A
Lisanby
Sarah
S
D000328:Adult; D018592:Cross-Over Studies; D046690:Deep Brain Stimulation / Q000379:methods*; D003861:Depersonalization / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D013702:Temporal Lobe / Q000502:physiology*; D016896:Treatment Outcome