title: Predictive factors of failure in management of ectopic pregnancy with single-dose methotrexate: a general population-based analysis from the Auvergne Register, France.
abstract: In a general population setting, the existence of a learning curve for treatment of ectopic pregnancy with single-dose methotrexate has been demonstrated, because a significant decrease in failure rate can be achieved over time. Despite this finding, the risk of single-dose methotrexate failure increases significantly in patients with initial hCG levels>1,300 IU/L and/or in women who report having ever used combined oral contraception before pregnancy.
authors.affiliation: Department of Gynecology-Obstetrics and Human Reproduction, CHU Clermont-Ferrand, Clermont-Ferrand, France. brabischong@chu-clermontferrand.fr
authors.forename: Benoit
authors.initials: B
authors.lastname: Rabischong
authors.forename: Xavier
authors.initials: X
authors.lastname: Tran
authors.forename: Aline Abi
authors.initials: AA
authors.lastname: Sleiman
authors.forename: Demetrio
authors.initials: D
authors.lastname: Larraín
authors.forename: Patricia
authors.initials: P
authors.lastname: Jaffeux
authors.forename: Bruno
authors.initials: B
authors.lastname: Aublet-Cuvelier
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pouly
authors.forename: Hervé
authors.initials: H
authors.lastname: Fernandez
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D004351:Drug Resistance; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008727:Methotrexate / Q000008:administration & dosage*; D009017:Morbidity; D011237:Predictive Value of Tests; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D003277:Contraceptives, Oral, Combined; D008727:Methotrexate