NIR-enhanced drug release from porous Au/SiO2 nanoparticles.
The ability of core/shell SiO(2)/Au nanoparticles (NPs) to heat upon being exposed to near-infrared (NIR) radiation is well known. In this work we have modified the synthesis procedure to obtain a mesoporous SiO(2) core and a porous Au shell that allows drugs to be loaded within the core porous space. The release of a model drug (ibuprofen) upon NIR activation is demonstrated.
Yagüe
Clara
C
Institute of Nanoscience of Aragón, University of Zaragoza, 50018 Zaragoza, Spain.
Arruebo
Manuel
M
Santamaria
Jesus
J
D003692:Delayed-Action Preparations / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage*; D007259:Infrared Rays; D007834:Lasers; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
D003692:Delayed-Action Preparations; D006046:Gold; D012822:Silicon Dioxide; D007052:Ibuprofen