title: Effects of calcium phosphate cement on the peripheral nerve fibers.
abstract: Calcium phosphate cement (CPC) is a bioactive ceramic substance. To clarify the effects of CPC on the peripheral nerve, we applied CPC on the peripheral nerve fibers of experimental animals and investigated the nerve fibers by electron microscopy and by immunoblotting analysis using an anti-myelin-associated glycoprotein (anti-MAG) antibody. The results showed that there was neither axonal sprouting at the nodes of Ranvier nor down-regulation of MAG beyond the normal level in the nerve fibers. These findings suggest that there is no harm in using CPC near the peripheral nerve fibers.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Japan. sachiko_munemoto@mhi.co.jp
authors.forename: Sachiko
authors.initials: S
authors.lastname: Munemoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Maho
authors.initials: M
authors.lastname: Murata
authors.forename: Junichiro
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Ikehata
authors.forename: Masaki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Umeda
authors.forename: Takahide
authors.initials: T
authors.lastname: Komori
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000633:toxicity*; D002130:Calcium Phosphates / Q000633:toxicity*; D005260:Female; D008422:Materials Testing; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D018992:Myelin-Associated Glycoprotein; C020243:calcium phosphate