title: Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery.
abstract: The grafting of drugs to the single-walled carbon nanotube (SWCNT) was attained by the initial conversion of carboxylic groups in SWCNT to corresponding acyl chlorides. The active acyl chlorides in SWCNT were subsequently mixed with chemotherapeutic agents having NH, NH2, and OH functional groups to afford the formation of relevant amide and ester, respectively. The covalently grafted drugs to SWCNT were identified by infrared and UV-visible spectroscopy and transmission electron microscopy methods. From a clinical aspect, the grafting of drugs to the SWCNT can be used as a new tool and useful method for potential drug delivery in patients.
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. khazaei_1326@yahoo.com
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Khazaei
authors.forename: Mohammad Navid Soltani
authors.initials: MN
authors.lastname: Rad
authors.forename: Maryam Kiani
authors.initials: MK
authors.lastname: Borazjani
mesh_terms: D001621:Betahistine / Q000008:administration & dosage; D004176:Dipyridamole / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D013055:Spectrophotometry, Infrared
chemical_list: D004337:Drug Carriers; D037742:Nanotubes, Carbon; D004176:Dipyridamole; D001621:Betahistine