title: Detection of congestive heart failure in dogs by Doppler echocardiography.
abstract: BACKGROUND
  Echocardiographic prediction of congestive heart failure (CHF) in dogs has not been prospectively evaluated.
  
  
  OBJECTIVE
  CHF can be predicted by Doppler echocardiographic (DE) variables of left ventricular (LV) filling in dogs with degenerative mitral valve disease (MVD) and dilated cardiomyopathy (DCM).
  
  
  METHODS
  Sixty-three client-owned dogs.
  
  
  METHODS
  Prospective clinical cohort study. Physical examination, thoracic radiography, analysis of natriuretic peptides, and transthoracic echocardiography were performed. Diagnosis of CHF was based upon clinical and radiographic findings. Presence or absence of CHF was predicted using receiver-operating characteristic (ROC) curve, multivariate logistic and stepwise regression, and best subsets analyses.
  
  
  RESULTS
  Presence of CHF secondary to MVD or DCM could best be predicted by E:isovolumic relaxation time (IVRT) (area under the ROC curve [AUC]=0.97, P<.001), respiration rate (AUC=0.94, P<.001), Diastolic Functional Class (AUC=0.93, P<.001), and a combination of Diastolic Functional Class, IVRT, and respiration rate (R2=0.80, P<.001) or Diastolic Functional Class (AUC=1.00, P<.001), respiration rate (AUC=1.00, P<.001), and E:IVRT (AUC=0.99, P<.001), and a combination of Diastolic Functional Class and E:IVRT (R2=0.94, P<.001), respectively, whereas other variables including N-terminal pro-brain natriuretic peptide, E:Ea, and E:Vp were less useful.
  
  
  CONCLUSIONS
  Various DE variables can be used to predict CHF in dogs with MVD and DCM. Determination of the clinical benefit of such variables in initiating, modulating, and assessing success of treatments for CHF needs further study.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. schober.4@osu.edu
authors.forename: K E
authors.initials: KE
authors.lastname: Schober
authors.forename: T M
authors.initials: TM
authors.lastname: Hart
authors.forename: J A
authors.initials: JA
authors.lastname: Stern
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: V F
authors.initials: VF
authors.lastname: Samii
authors.forename: L J
authors.initials: LJ
authors.lastname: Zekas
authors.forename: B A
authors.initials: BA
authors.lastname: Scansen
authors.forename: J D
authors.initials: JD
authors.lastname: Bonagura
mesh_terms: D000818:Animals; D003971:Diastole; D004283:Dog Diseases / Q000097:blood / Q000000981:diagnostic imaging*; D004285:Dogs; D015150:Echocardiography, Doppler / Q000662:veterinary*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000662:veterinary*; D008297:Male; D008943:Mitral Valve / Q000502:physiology; D045265:Natriuretic Peptides / Q000097:blood; D056152:Respiratory Rate
chemical_list: D045265:Natriuretic Peptides