title: The association between blood glucose and oxidized lipoprotein(a) in healthy young women.
abstract: BACKGROUND
  Oxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein. Increased blood glucose concentrations can induce oxidative modification of lipoproteins. The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose.
  
  
  METHODS
  Several cardiometabolic variables and serum oxLp(a) (using an ELISA system) were measured among 70 healthy females (mean age, 22 years).
  
  
  RESULTS
  Lp(a) and glucose were significantly and positively correlated with oxLp(a) in simple correlation test. Furthermore, a multiple linear regression analysis showed oxLp(a) to have a weakly, but significantly positive and independent correlation with only blood glucose (β = 0.269, P < 0.05).
  
  
  CONCLUSIONS
  These results suggest that increased glucose may enhance the oxidization of Lp(a) even at normal glucose levels.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamada
authors.forename: Shuumarjav
authors.initials: S
authors.lastname: Uurtuya
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamada
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Taniguchi
authors.forename: Ikunosuke
authors.initials: I
authors.lastname: Sakurabayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D053241:Apoprotein(a) / Q000097:blood / Q000737:chemistry; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology*; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood* / Q000737:chemistry*; D008074:Lipoproteins / Q000097:blood; D010084:Oxidation-Reduction; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008055:Lipids; D017270:Lipoprotein(a); D008074:Lipoproteins; D053241:Apoprotein(a)