Anticoagulation for atrial fibrillation: should warfarin be temporarily stopped or continued after acute cardioembolic stroke?
Despite anticoagulation for atrial fibrillation, some patients still suffer an ischaemic stroke. The issue of whether to stop or continue warfarin, or possibly to reverse the anticoagulation is an area of uncertainty. Continued anticoagulation may, however, increase haemorrhagic transformation of the infarct. In this article we review the published evidence in an attempt to quantify the risks and benefits of each treatment strategy and identify areas for further research.
Mudd
Paul D
PD
Department of Stroke Medicine, Royal Devon and Exeter Hospital, Exeter, Devon, UK. paul.mudd@doctors.org.uk
James
Martin A
MA
D000208:Acute Disease; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000453:epidemiology*; D019317:Evidence-Based Medicine; D006801:Humans; D020766:Intracranial Embolism / Q000453:epidemiology*; D008297:Male; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*; D014859:Warfarin / Q000008:administration & dosage*
D000925:Anticoagulants; D014859:Warfarin