[Regulations of Hedgehog signaling pathway on mesenchymal stem cells].
OBJECTIVE
To summarize the regulations of Hedgehog signaling pathway on the proliferation and multi-differentiation of mesenchymal stem cells (MSCs).


METHODS
The related literature in recent years concerning the regulations of Hedgehog signaling pathway on the biological characteristics of MSCs was reviewed and analyzed.


RESULTS
Hedgehog signaling pathway promoted the proliferation of MSCs, and played a major role in the induction of osteogenic and chondrogenic differentiations, but it inhibited the adipocytic differentiation.


CONCLUSIONS
The regulations of Hedgehog signaling pathway in MSCs multi-differentiation and proliferation could be used as the new therapeutic targets of tissue ischemia, osteoporosis, achondroplasia, obesity, and so on.
Cai
Jiaqin
J
Department of Pharmacology, West China School of Pharmacy, Sichuan University, 610041, PR China.
Deng
Li
L
D050156:Adipogenesis; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology; D053823:Hedgehog Proteins / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction
D053823:Hedgehog Proteins