Sodium iodide associated to salicylic acid in the topical management of chronic oral candidiasis: a randomized trial.
Candidiasis is a relevant problem in oral medicine practice. We compared the antimycotic activity of nystatin with a solution of sodium iodide associated to salicylic acid (SISA) in the topical management of chronic candidiasis. Consecutive patients affected by chronic candidiasis were randomly allocated to SISA (group A) or nystatin (group B). VAS and swab scores were recorded at the beginning and at the end of the study while the healing index was evaluated at the end of the study only. Data were analyzed by STATA 10 MP. Forty patients (20 male, 20 female) were randomized. SIAS was as effective as nystatin in affecting VAS (p greater than 0.05) and swab score (p greater than 0.05). A statistically significant reduction (p less than 0.05) of healing index was observed in both groups. No side effects were reported. SISA topical application, shows a comparable efficacy to the nystatin in the management of chronic oral candidiasis. Its use could represent an adequate alternative to the nystatin above all in the cases of drug-resistance. Further large scale randomized trials are warranted to confirm these preliminary findings.
Petruzzi
M
M
Grassi
F R
FR
Nardi
G M
GM
Martinelli
D
D
Serpico
R
R
Luglie
P F
PF
Baldoni
E
E
D000328:Adult; D000368:Aged; D002180:Candidiasis, Oral / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009761:Nystatin / Q000627:therapeutic use; D010147:Pain Measurement; D020156:Salicylic Acid / Q000627:therapeutic use*; D012974:Sodium Iodide / Q000627:therapeutic use*
D009761:Nystatin; D012974:Sodium Iodide; D020156:Salicylic Acid