[Recent knowledges on chemosensitivity to hypoxia and hypercapnia in cardiovascular disease].
The pathophysiologic role of enhanced chemosensitivity to carbon dioxide and/or hypoxia has been underscored in several cardiovascular diseases, including heart failure. In the early stages of this syndrome, the chemoreflex acts as a compensatory mechanism. Later on, however, it contributes to sustain the sympathetic activation, with detrimental effects on cardiovascular function and prognosis.
Passino
Claudio
C
UO Medicina Cardiovascolare, Fondazione Gabriele Monasterio, Pisa. passino@ftgm.it
Giannoni
Alberto
A
Milli
Massimo
M
Polettii
Roberta
R
Emdin
Michele
M
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D035843:Biomedical Research; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002628:Chemoreceptor Cells; D002639:Cheyne-Stokes Respiration / Q000503:physiopathology / Q000628:therapy; D003643:Death; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D010101:Oxygen Consumption; D011379:Prognosis; D051381:Rats; D012018:Reflex / Q000502:physiology; D012119:Respiration; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000502:physiology; D013997:Time Factors; D015013:Yoga