title: Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus.
abstract: We evaluated the effect of aminoguanidine on pulmonary oxidative stress and lung structure in an experimental model of diabetes mellitus. Thiobarbituric acid reactive substances (TBARS), histology and arterial blood gases were evaluated in animals with diabetes mellitus (DM group), animals with diabetes mellitus treated with aminoguanidine (DM+AG group), and controls. The TBARS levels were significantly higher in the DM group than in the control and DM+AG groups (2.90 ± 1.12 vs. 1.62 ± 0.28 and 1.68 ± 0.04 nmol/mg protein, respectively), as was PaCO2 when compared with that of the control group (49.2 ± 1.65 vs. 38.12 ± 4.85 mmHg), and PaO2 was significantly higher in the control group (104.5 ± 6.3 vs. 16.30 ± 69.48 and 97.05 ± 14.02 mmHg, respectively). In this experimental model of diabetes mellitus, aminoguanidine reduced oxidative stress, structural tissue alterations, and gas exchange.
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors.forename: Fabio Cangeri
authors.initials: FC
authors.lastname: Di Naso
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Forgiarini Junior
authors.forename: Luiz Felipe
authors.initials: LF
authors.lastname: Forgiarini
authors.forename: Marilene
authors.initials: M
authors.lastname: Porawski
authors.forename: Alexandre Simões
authors.initials: AS
authors.lastname: Dias
authors.forename: Norma Anair Possa
authors.initials: NA
authors.lastname: Marroni
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology*; D006146:Guanidines / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D006146:Guanidines; D017392:Thiobarbituric Acid Reactive Substances