title: Serum leptin, adiponectin and tumor necrosis factor-α in hyperlipidemic rats with/without concomitant diabetes mellitus.
abstract: We compared the lipid profiles and serum levels of leptin, adiponectin and tumor necrosis factor-α (TNF-α) in rats with/without hyperlipidemia and with/without concomitant diabetes mellitus. Forty 10-wk-old male Wistar rats were divided into four groups. Groups A and C received standard food for 12 wks. Groups B and D received a high-fat diet enriched with 2% additional cholesterol. Moreover, insulin-deficient (type I) diabetes mellitus was induced in rats in groups C and D with intraperitoneal injections of streptozotocin. Fasting serum leptin levels were decreased in diabetic groups (groups C and D) compared with controls. Fasting serum adiponectin levels were decreased in groups C and D compared with group A. Serum TNF-α levels were augmented in groups B and D, those fed with an atherogenic diet. By contrast, TNF-α levels were decreased in group C. Our data suggest that serum leptin, adiponectin and TNF-α levels may serve as markers of obesity and type I diabetes mellitus.
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, Athens, Greece.
authors.forename: Angeliki
authors.initials: A
authors.lastname: Margoni
authors.forename: Despoina N
authors.initials: DN
authors.lastname: Perrea
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vlachos
authors.forename: Georgia
authors.initials: G
authors.lastname: Prokopaki
authors.forename: Alkistis
authors.initials: A
authors.lastname: Pantopoulou
authors.forename: Lambros
authors.initials: L
authors.lastname: Fotis
authors.forename: Maria
authors.initials: M
authors.lastname: Kostaki
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha