title: The evolvability of lead peptides from small library screens.
abstract: Very little is known about the evolvability of lead peptides that are isolated from small library screens. Here we begin to explore this question by comparing the directed evolution of two peptides previously isolated from a small library screen to new ligands generated de novo by in vitro selection.
authors.affiliation: Center for Evolutionary Medicine and Informatics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287-5301, USA.
authors.forename: Jinglei
authors.initials: J
authors.lastname: Zhang
authors.forename: Berea A R
authors.initials: BA
authors.lastname: Williams
authors.forename: Mikael T
authors.initials: MT
authors.lastname: Nilsson
authors.forename: John C
authors.initials: JC
authors.lastname: Chaput
mesh_terms: D000595:Amino Acid Sequence; D019020:Directed Molecular Evolution / Q000379:methods*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011487:Protein Conformation; D014168:Transferrin / Q000737:chemistry / Q000378:metabolism
chemical_list: D008024:Ligands; D019151:Peptide Library; D010455:Peptides; D014168:Transferrin