title: Endoscopic evaluation of Crohn's disease activity: comparison of the CDEIS and the SES-CD.
abstract: BACKGROUND
  Few data exist of prospective parallel scoring of the validated endoscopic scores in Crohn's disease (CD), Crohn's Disease Index of Severity (CDEIS), and Simple Endoscopic Score for Crohn's Disease (SES-CD).
  
  
  METHODS
  Both the CDEIS and the SES-D were scored immediately after each endoscopy of 86 CD patients referred for ileocolonoscopy in a cross-sectional study. Furthermore, after CD therapy, 32 CD patients underwent a follow-up endoscopy with scoring of the CDEIS and SES-CD. Endoscopic scorings were graded as inactive, mild, moderate, or severe. Clinical activity was assessed with the Crohn's Disease Activity Index (CDAI) and serum C-reactive protein (CRP) was measured.
  
  
  RESULTS
  The SES-CD correlated with the CDEIS significantly (Spearman's r = 0.938, P < 0.0001). Weaker correlations were detected between the SES-CD and the CDAI (r = 0.473) or CRP (r = 0.525, both P < 0.0001). Grading of SES-CD from inactive to severe correlated significantly with grading of the CDEIS (r = 0.859, P < 0.0001). Changes between baseline and follow-up endoscopy scores correlated significantly (r = 0.828 between delta-CDEIS and delta-SES-CD, P < 0.001), but failed to correlate with delta-CDAI or delta-CRP (all P > 0.05).
  
  
  CONCLUSIONS
  Both validated endoscopic scores, the CDEIS and SES-CD, and their changes during CD therapy demonstrated a close correlation. For scoring of endoscopic activity in clinical routine, the SES-CD could replace the CDEIS.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland. taina.sipponen@kolumbus.fi
authors.forename: Taina
authors.initials: T
authors.lastname: Sipponen
authors.forename: Hannu
authors.initials: H
authors.lastname: Nuutinen
authors.forename: Ulla
authors.initials: U
authors.lastname: Turunen
authors.forename: Martti
authors.initials: M
authors.lastname: Färkkilä
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D003424:Crohn Disease / Q000378:metabolism / Q000473:pathology*; D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein