Female meiosis: coming unglued with age.
Chromosome abnormalities in humans are strikingly associated with increasing maternal age. Studies in mice implicate loss of chromosome cohesion as an important cause of age-related meiotic errors in the oocyte.
Hunt
Patricia
P
School for Molecular Biosciences, Washington State University, WA 99164, USA. pathunt@wsu.edu
Hassold
Terry
T
D000375:Aging / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D008540:Meiosis; D009865:Oocytes / Q000166:cytology