Hydrolysates of citrus plants stimulate melanogenesis protecting against UV-induced dermal damage.
The sun-tanning process occurs as a spontaneous response to ultraviolet (UV) irradiation. UV will induce tanning and DNA damage, processes that can lead to photoaging and skin disorders such as hyperpigmentation and cancer. The pigment melanin protects skin from UV damage; therefore, an efficient melanin-promoting suntan lotion could be highly beneficial. In this study, a process was developed to increase the content of naringenin in citrus extracts and to determine whether a higher naringenin content of citrus would induce melanogenesis. Melanin content and tyrosinase expression in mouse B16 melanoma cells were assayed after treatment with citrus plant extracts and their hydrolysates. The results indicate that hydrolysis increased the naringenin content in citrus extracts and that citrus preparations stimulated cellular melanogenesis and tyrosinase expression. It is suggested that this method is applicable to the industrial production of melanin-promoting suntan lotions with antiphotocarcinogenic properties derived from citrus rind and citrus products.
Chiang
Hsiu-Mei
HM
Department of Cosmeceutics, China Medical University, Taichung, Taiwan.
Lin
Jen-Wen
JW
Hsiao
Pei-Ling
PL
Tsai
Shang-Yuan
SY
Wen
Kuo-Ching
KC
D000818:Animals; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000378:metabolism*; D006868:Hydrolysis; D008543:Melanins / Q000096:biosynthesis* / Q000378:metabolism; D008546:Melanoma, Experimental / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D008543:Melanins; D010936:Plant Extracts; D014442:Monophenol Monooxygenase