title: Prevalence of multidrug and extensively drug-resistant tuberculosis in Beijing, China: a hospital-based retrospective study.
abstract: Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital-based survey in Beijing, China, conducted in the period 2007 to 2009. Drug-susceptibility tests performed on 967 Mycobacterium tuberculosis strains isolated from 967 patients showed that the rate of resistance to at least one first-line and at least one second-line drug was 70.1% and 60.7%, respectively. The overall MDR rate was 19.4%, and 14.9% of the MDR cases were XDR. In conclusion, MDR and XDR TB represent a significant number of total TB cases, therefore effective measures to manage these resistant strains are desperately needed. Development of a national TB policy in China might be a key method for solving the present problems of TB management.
authors.affiliation: Department of Clinical Laboratory, PLA 309 Hospital, Beijing, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.forename: Caie
authors.initials: C
authors.lastname: Yang
authors.forename: Tieji
authors.initials: T
authors.lastname: Kuang
authors.forename: Hong
authors.initials: H
authors.lastname: Lei
authors.forename: Xianghong
authors.initials: X
authors.lastname: Meng
authors.forename: Aihua
authors.initials: A
authors.lastname: Tong
authors.forename: Jufang
authors.initials: J
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Fengjie
authors.initials: F
authors.lastname: Guo
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D054908:Extensively Drug-Resistant Tuberculosis / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015995:Prevalence; D012189:Retrospective Studies
chemical_list: D000995:Antitubercular Agents