title: Antifungal activity of posaconazole against Candida spp. and non-Candida clinical yeasts isolates.
abstract: The in vitro antifungal activity of posaconazole was tested against 315 yeast clinical isolates and 11 ATCC reference strains by means an agar diffusion method (Neosensitabs, Rosco,Denmark) based in CLSI M44-A2 document. Posaconazole activity was excellent against Cryptococcus and Rhodotorula species studied and showed very good activity against most species of Candida tested. A total of 13 clinical isolates (4.1%) were resistant: Candida albicans (n=5), Candida glabrata (n=5), Candida tropicalis (n=1), Geotrichum australiensis (n=1) and Geotrichum capitatum (n=1). Our results suggest posaconazole is an effective antifungal agent against the most clinically important yeasts species (92.7% of susceptibility). Agar diffusion method provides good conditions for the posaconazole susceptibility study in the routine laboratory.
authors.affiliation: Dept. Microbiología. ACIAM, Barcelona, Spain. acarrillo@aciam.es
authors.forename: A J
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: C
authors.initials: C
authors.lastname: Tur-Tur
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández-Molina
authors.forename: G
authors.initials: G
authors.lastname: Quindós
authors.forename: C
authors.initials: C
authors.lastname: Marcos-Arias
authors.forename: E
authors.initials: E
authors.lastname: Eraso
authors.forename: D
authors.initials: D
authors.lastname: Cárdenes
authors.forename: O
authors.initials: O
authors.lastname: Ortiz-Maestro
authors.forename: P
authors.initials: P
authors.lastname: Santos
authors.forename: D
authors.initials: D
authors.lastname: Estivill
authors.forename: C
authors.initials: C
authors.lastname: Guardia
authors.forename: G
authors.initials: G
authors.lastname: Giusiano
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*; D014230:Triazoles / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole