Effects of calcium phosphate cement on the peripheral nerve fibers.
Calcium phosphate cement (CPC) is a bioactive ceramic substance. To clarify the effects of CPC on the peripheral nerve, we applied CPC on the peripheral nerve fibers of experimental animals and investigated the nerve fibers by electron microscopy and by immunoblotting analysis using an anti-myelin-associated glycoprotein (anti-MAG) antibody. The results showed that there was neither axonal sprouting at the nodes of Ranvier nor down-regulation of MAG beyond the normal level in the nerve fibers. These findings suggest that there is no harm in using CPC near the peripheral nerve fibers.
Munemoto
Sachiko
S
Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Japan. sachiko_munemoto@mhi.co.jp
Shibuya
Yasuyuki
Y
Murata
Maho
M
Takeuchi
Junichiro
J
Ikehata
Noriko
N
Kobayashi
Masaki
M
Suzuki
Hiroaki
H
Umeda
Masahiro
M
Komori
Takahide
T
D000818:Animals; D001843:Bone Cements / Q000633:toxicity*; D002130:Calcium Phosphates / Q000633:toxicity*; D005260:Female; D008422:Materials Testing; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D001843:Bone Cements; D002130:Calcium Phosphates; D018992:Myelin-Associated Glycoprotein; C020243:calcium phosphate