title: Transport of pharmaceuticals in columns of a wastewater-irrigated Mexican clay soil.
abstract: The irrigation or agricultural land with wastewater is increasingly practiced in many parts of the world as a consequence of growing populations and urbanization. The risks emerging from pharmaceuticals that are contained in wastewater for soils and groundwater have hardly been investigated. We studied leaching and effects of naproxen, ibuprofen, bezafibrate, diclofenac, gemfibrocil, clarithromycin, trimethoprim, clindamycin, erythromycin, and metoprolol in a soil column experiment simulating an irrigation event with 8.6 cm of wastewater containing 20 microg L(-1) or 2000 microg L(-1) of each compound or of erythromycin alone. The leached fraction of applied pharmaceuticals ranged from 0.1 +/- 0.1% (clarithromycin, 2000 microg L(-1)) to 130 +/- 41% (naproxen, 20 microg L(-1)) and tended to increase with decreasing K(d) or K(oc). Naproxen transport was similar to that of the tracer chloride. Ibuprofen was also hardly retarded (R = 1.20 +/- 0.18), but showed a higher degradation rate of 0.02 +/- 0.004 h(-1) (2000 microg L(-1)) than naproxen. The transport of a pulse of 2000 microg L(-1) of bezafibrate could be described with a retardation factor of 1.5 and a degradation rate of 0.033 h(-1). The application of erythromycin alone or of a cocktail of all pharmaceuticals significantly increased soil CO2 emissions by 50% 1 d after the application. There is a considerable risk that pharmaceuticals are leached to groundwater during wastewater irrigation.
authors.affiliation: Univ. of Bonn, Institute of Crop Science and Resource Conservation, Soil Science, Nussallee 13, 53115 Bonn, Germany. jan.siemens@uni-bonn.de
authors.forename: Jan
authors.initials: J
authors.lastname: Siemens
authors.forename: Gerd
authors.initials: G
authors.lastname: Huschek
authors.forename: Gillian
authors.initials: G
authors.lastname: Walshe
authors.forename: Christina
authors.initials: C
authors.lastname: Siebe
authors.forename: Roy
authors.initials: R
authors.lastname: Kasteel
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wulf
authors.forename: Joachim
authors.initials: J
authors.lastname: Clemens
authors.forename: Martin
authors.initials: M
authors.lastname: Kaupenjohann
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry; D000077215:Clay; D004784:Environmental Monitoring; D008800:Mexico; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012987:Soil / Q000032:analysis; D012989:Soil Pollutants / Q000737:chemistry*; D014865:Waste Disposal, Fluid / Q000379:methods*
chemical_list: D000538:Aluminum Silicates; D002712:Chlorides; D004364:Pharmaceutical Preparations; D012987:Soil; D012989:Soil Pollutants; D000077215:Clay