[Metabonomic study of the urine of rat acute gouty arthritis model].
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OBJECTIVE
To analysis the metabonome characteristics of the urine of MSU crystal-induced acute gouty arthritis rats by the method of metabolomics.


METHODS
Based on the method of metabolomics, which applies LC/MS as data acquisition platform, incorporating with the means of stoechiometry such as principal component analysis, we analyzed the metabonome difference between the urine of acute gouty arthritis rats and that of normal rats.


RESULTS
Compare with control group, the metabolism status of acute gouty arthritis model group deviated. After that, with the time lapsed, it retrieved gradually to the incipient metabolism status. The variation of metabolism locus of rats measured by the methods of metabolomics properly reflects the genesis, development, and recuperation course of acute gouty arthritis.


CONCLUSIONS
The whole metabolism status of rat model is able to be presented finely with the method of metabolomics. The metabolomics study could offer a satisfactory research approach to acute gouty arthritis.
Zhu
Hong-Yuan
HY
School of Life Science, Sichuan University, Chengdu 610064, China.
Xiao
Jin
J
Liu
Yu-Jie
YJ
Cui
Yan
Y
Ye
Li-Ming
LM
Yin
Hai-Lin
HL
D000818:Animals; D015210:Arthritis, Gouty / Q000652:urine*; D002853:Chromatography, Liquid / Q000379:methods; D004195:Disease Models, Animal; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D055442:Metabolome / Q000502:physiology*; D055432:Metabolomics / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley