Targeting karyotypic complexity and chromosomal instability of cancer cells.
Multiple karyotypic abnormalities and chromosomal instability are characteristic features of many cancers that are relatively resistant to chemotherapeutic agents currently used in the clinic. These same features represent potentially targetable "states" that are essentially tumor specific. The assessment of the chromosomal state of a cancer cell population may provide a guide for the selection or development of drugs active against aggressive and intractable cancers.
Roschke
Anna V
AV
Genetics Branch, Center for Cancer Research, National Cancer Institute, Building NNMC8, Room 5101, Bethesda, MD 20889-5105, USA. roschkea@mail.nih.gov
Kirsch
Ilan R
IR
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D043171:Chromosomal Instability; D002869:Chromosome Aberrations; D016503:Drug Delivery Systems; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D010641:Phenotype
D000970:Antineoplastic Agents