title: Encountering cancer or its sequelae at the hip.
abstract: The orthopedist may need act as an adjunct to the medical oncologist in the management of the cancer patient with hip disease. While management of the cancer patient with routine hip pathology is relatively straightforward, the surgeon should be aware that the cancer patient may be on treatment protocols that affect wound healing, the immune system, and the risk of deep venous thrombosis. An additional factor that may complicate management of patients who have completed treatment of peripelvic cancer may be local radiation therapy, which can lead to necrosis of the acetabular bone stock. Operating on these patients must include consultation with previous radiation therapy providers to estimate the dose sustained by the local tissues under consideration. Greater than 500 cGy has been associated with high fixation failure rates in several series. Increased rates of infection and wound healing have also been noted secondary to long-term lymphatic obliteration caused by radiation. These concerns also affect the surgeon who must manage patients with acute metastatic disease. The principles of managing metastatic disease include recognizing the presence of lesions in bone about the hip, the occasional need for biopsy, the use of radiation in sensitive tumors, surgical stabilization of impending fracture, or joint replacement when needed. The amount of tumor, as well as the effect of chemotherapy and radiation on the healing process, potentially complicates these treatment modalities.
authors.affiliation: Rush Medical College, Chicago, Illinois, USA. aarongbone@aol.com
authors.forename: Aaron
authors.initials: A
authors.lastname: Rosenberg
mesh_terms: D000077:Acetabulum / Q000528:radiation effects*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D007400:Interprofessional Relations; D009985:Orthopedics; D010384:Pelvic Bones / Q000473:pathology; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D011475:Prosthesis Failure; D018787:Radiation Oncology; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage