A new diimide derivative from the co-culture broth of two mangrove fungi (strain no. E33 and K38).
A new diimide derivative, named (-)-byssochlamic acid bisdiimide (1), was isolated from the mixed broth of two mangrove fungi (strain no. K38 and E33) from the South China sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) and semi-synthesis. Primary bioassays showed that 1 had weak cytotoxic activity against Hep-2 and HepG2 cells.
Li
Chun-Yuan
CY
College of Science, Institute of Biomaterial, South China Agricultural University, Guangzhou, China.
Ding
Wei-Jia
WJ
Shao
Chang-Lun
CL
She
Zhi-Gang
ZG
Lin
Yong-Cheng
YC
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D056945:Hep G2 Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D005663:Furans; D006575:Heterocyclic Compounds, 3-Ring; D007094:Imides; C552795:byssochlamic acid bisdiimide; C010875:byssochlamic acid