title: Microcirculation in cardiogenic shock: from scientific bystander to therapy target.
abstract: Despite diagnostic and therapeutic improvements, mortality rates in patients with cardiogenic shock remain relatively high. Several studies showed that cardiogenic shock is associated with alterations in the microvascular circulation. These alterations may be reversed by extracorporeal support devices. A study by Munsterman and colleagues adds to the body of evidence showing that in patients deemed ready for discontinuing intra-aortic balloon pump (IABP) support, microcirculatory flow in small vessels increases after ceasing IABP therapy. This study not only highlights the need for optimal timing of weaning from IABP support but also supports recent findings that global hemodynamics do not necessarily result in changes of microvascular perfusion. All modalities of modern treatment in cardiogenic shock need to be evaluated for their effect on the microcirculation. Microcirculatory evaluations should be part of randomized controlled trial protocols. More effort is needed to improve outcomes and understand the microcirculation as a therapy target and not as a silent bystander.
authors.affiliation: First Department of Internal Medicine, (Cardiology, Angiology, Pneumology, Intensive Care Medicine), Friedrich-Schiller University, Erlanger Allee 101, 07740 Jena, Germany. christian.jung@med.uni-jena.de
authors.forename: Christian
authors.initials: C
authors.lastname: Jung
authors.forename: Alexander
authors.initials: A
authors.lastname: Lauten
authors.forename: Markus
authors.initials: M
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000639:trends; D005112:Extracorporeal Circulation / Q000639:trends; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000639:trends; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012770:Shock, Cardiogenic / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D002316:Cardiotonic Agents