Binary mixing of micelles using Pluronics for a nano-sized drug delivery system.
Pluronics with different structural compositions and properties are used for several applications, including drug delivery systems. We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and high solubilization capacity due to Pluronic L121. The binary systems were spherical and less than 200-nm diameter, with high thermodynamic stability (at least 2 weeks) in aqueous solution. The CMC of the binary system was located in the middle of the CMC of each polymer. In particular, the solubilization capacity of the binary system (0.1/0.1 wt%) was higher than mono-systems of P123. The main advantage of binary systems is overcoming limitations of mono systems to allow tailored mixing of block copolymers with different physicochemical characteristics. These nano-sized systems may have potential as anticancer drug delivery systems with simple preparation method, high stability, and high loading capacity.
Lee
Eun Seong
ES
Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
Oh
Young Taik
YT
Youn
Yu Seok
YS
Nam
Myounghwa
M
Park
Byungtae
B
Yun
Jungmin
J
Kim
Ji Hoon
JH
Song
Ho-Taek
HT
Oh
Kyung Taek
KT
D001391:Azo Compounds / Q000737:chemistry; D016503:Drug Delivery Systems; D005453:Fluorescence; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D009391:Nephelometry and Turbidimetry; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013057:Spectrum Analysis
D001391:Azo Compounds; D008823:Micelles; D012996:Solutions; D020442:Poloxamer; C033006:sudan III