title: Pre-existing chiasma syndromes do not entirely remit following transsphenoidal surgery for pituitary adenomas.
abstract: BACKGROUND
  It is not known whether following transsphenoidal surgery for pituitary adenomas the vision of patients with preoperative chiasma syndromes (CS) does improve to the degree of vision of patients without preoperative CS.
  
  
  OBJECTIVE
  The purpose of this study is to answer the question above.
  
  
  METHODS
  Pertinent data of a successive series of patients operated transsphenoidally for the first time for pituitary adenoma were retrospectively analysed.
  
  
  RESULTS
  Of the 304 patients, 35.1% presented preoperatively with CS. The median visual acuity (VA) of these patients improved significantly from preoperative (right eye, 0.63 (0; 1.25); left eye, 0.56 (0; 1.4)) to postoperative (right eye, 0.8 (0; 1.25); left eye, 0.74 (0; 1.25)). The median number of impaired quadrants of the binocular visual fields (VF) improved significantly from preoperative (2 (0; 8)) to postoperative CS (0 (0; 4)). In patients without preoperative CS, postoperative vision (VA as well as VF) remained unchanged. Postoperatively, VA of patients with preoperative CS remained significantly lower than that of patients without preoperative CS (right eye, 0.96 (0.2; 1.4); left eye, 0.94 (0.05; 1.4)). Postoperatively, the number of impaired quadrants of the binocular VF of patients with preoperative CS remained significantly higher than in patients without preoperative CS (0 (0; 1)).
  
  
  CONCLUSIONS
  In this unselected patient series, the vision (VA as well as VF) of patients with preoperative CS did not improved postoperatively to the degree of the vision of patients without preoperative CS. Thus, in patients with adenomatous chiasma compression transsphenoidal surgery may be indicated before CS develops.
authors.affiliation: Department of Neurosurgery, University of Bonn, Sigmund-Freud Str. 25, 53105 Bonn, Germany. Rudolf.Kristof@ukb.uni-bonn.de
authors.forename: Rudolf Andreas
authors.initials: RA
authors.lastname: Kristof
authors.forename: Daniel
authors.initials: D
authors.lastname: Kirchhofer
authors.forename: Daniel
authors.initials: D
authors.lastname: Handzel
authors.forename: Georg
authors.initials: G
authors.lastname: Neuloh
authors.forename: Johannes
authors.initials: J
authors.lastname: Schramm
authors.forename: Christian-Andreas
authors.initials: CA
authors.lastname: Mueller
authors.forename: Nicole
authors.initials: N
authors.lastname: Eter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006423:Hemianopsia / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods*; D009897:Optic Chiasm / Q000473:pathology / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D013100:Sphenoid Bone / Q000601:surgery*; D013577:Syndrome; D055815:Young Adult