In vitro sensitivity and resistance of 46 Leptospira strains isolated from rats in the Philippines to 14 antimicrobial agents.
The in vitro susceptibilities of 46 Leptospira isolates from rats to 14 antimicrobial agents were tested. All of the strains were found to be sensitive to ampicillin, cefotaxime, ciprofloxacin, norfloxacin, doxycycline, erythromycin, and streptomycin. In contrast, the tested isolates showed resistance to amphotericin B, 5-fluorouracil, fosfomycin, trimethoprim, sulfamethoxazole, neomycin, and vancomycin. These findings will help in selecting effective and ineffective antimicrobials for treatment of leptospirosis and for the development of new selective media, respectively.
Chakraborty
Antara
A
Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. antara@bact.med.kyushu-u.ac.jp
Miyahara
Satoshi
S
Villanueva
Sharon Y A M
SY
Gloriani
Nina G
NG
Yoshida
Shin-Ichi
S
D000666:Amphotericin B / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology; D007919:Leptospira / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology; D010679:Philippines; D051381:Rats; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D002939:Ciprofloxacin; D004917:Erythromycin; D014640:Vancomycin; D000667:Ampicillin; D000666:Amphotericin B; D014295:Trimethoprim; D009355:Neomycin; D013420:Sulfamethoxazole; D004318:Doxycycline; D002439:Cefotaxime; D005472:Fluorouracil