title: Early diagnosis of lung cancer using a SAFE-3000 autofluorescence bronchoscopy.
abstract: The aim of the study was to evaluate the double modality working of a new autofluorescence videobronchoscope SAFE-3000 for the detection and localization of precancerous and malignant lesions. From April to May 2009, 168 patients underwent SAFE-3000 bronchoscopy using 'Twin Mode' and 'Multiple Image Xposition (MIX)' technologies. The study considers only 97 patients with morphological alterations (visual score 2 or 3) of mucosa; four bronchial biopsies (two for every modality) have been performed on every patient. Histological diagnosis of the 388 biopsies revealed normal mucosa in 11 patients, four benign lesions, 27 precancerous lesions and 55 malignant lesions. The sensitivity of the 'Twin Mode' and 'MIX' techniques in the characterization of premalignant and malignant lesions was 96% vs. 100%. The specificity was 60% in both of these technologies. SAFE-3000 autofluorescence bronchoscopy allows an early diagnosis of preneoplastic or neoplastic lesions according to the careful analysis of the bronchial mucosa, due to the complementarity of two modalities 'Twin Mode' and 'MIX'. Based on the relationship between the bronchoscopic goal and the histological results the MIX method contributes more of the new endoscopic technique findings.
authors.affiliation: Department of Thoracic Surgery, University of L'Aquila, G. Mazzini Hospital, Piazza Italia 1, Circonvallazione Ragusa 39, 64100 Teramo, Italy. duilio.divisi@aslteramo.it
authors.forename: Duilio
authors.initials: D
authors.lastname: Divisi
authors.forename: Sergio
authors.initials: S
authors.lastname: Di Tommaso
authors.forename: Andrea
authors.initials: A
authors.lastname: De Vico
authors.forename: Roberto
authors.initials: R
authors.lastname: Crisci
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001980:Bronchi / Q000473:pathology*; D020680:Bronchoscopes; D001999:Bronchoscopy / Q000295:instrumentation*; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000473:pathology; D055088:Early Detection of Cancer; D004867:Equipment Design; D005260:Female; D005453:Fluorescence; D006801:Humans; D007558:Italy; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D020545:Respiratory Mucosa / Q000473:pathology; D012680:Sensitivity and Specificity; D013997:Time Factors; D014741:Video Recording