Development of photostable near-infrared cyanine dyes.
With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standard IndoCyanine Green (ICG).
Samanta
Animesh
A
Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543, Singapore.
Vendrell
Marc
M
Das
Rajkumar
R
Chang
Young-Tae
YT
D002232:Carbocyanines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
D002232:Carbocyanines; D004396:Coloring Agents