title: Endoscopic endonasal transsphenoidal surgery for sellar tumors in children.
abstract: OBJECTIVE
  Endoscopic endonasal transsphenoidal surgery (EETS) is still rarely used in pediatric subjects compared with adults. Reports on EETS in children appeared only recently in the literature, usually regarding small series. The aim of the study is to assess the actual role and the limits of EETS in children with sellar tumors by reporting a two-centers experience.
  
  
  METHODS
  Twenty-seven children (mean age: 12.2 years) were operated on during the last decade. Seventeen patients harbored a sellar mass, 7 a suprasellar tumor, and 3 a clival mass. Laboratory investigations revealed hypopituitarism in 6 children and hormone hypersecretion in 9. All the operations were carried out by a team including both ENT surgeon and neurosurgeon using a dedicated 18-cm long rigid endoscope (2.7 mm and 4 mm diameter) through the direct paraseptal or the transethmoidal or the transpterygoid route.
  
  
  RESULTS
  Overall, 29 operations were performed. Gross total tumor resection was obtained in 22 children (81.5%) while a subtotal and a partial removal in 2 (7.5%) and 3 cases (11%), respectively. Pituitary adenoma was the most common histotype (12 cases), followed by craniopharyngioma (5) and Rathke's cleft cyst (4). No surgical mortality or neurological morbidity or late nasal complications were observed. Postoperative CSF fistula occurred in 3 patients. All children are alive at current follow-up (average: 8.6 years). Preoperative hypopituitarism disappeared or improved in 4 cases and was stable in the remaining 2 (no new hormone deficits appeared).
  
  
  CONCLUSIONS
  EETS is a safe and effective surgical option also in children. As for adults, it allows to manage most of the tumor lesions of the sellar region with stable long-term results.
authors.affiliation: Department of Neurosurgery, San Matteo Hospital, Pavia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Locatelli
authors.forename: Luca
authors.initials: L
authors.lastname: Massimi
authors.forename: Mario
authors.initials: M
authors.lastname: Rigante
authors.forename: Viola
authors.initials: V
authors.lastname: Custodi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Paludetti
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
authors.forename: Concezio
authors.initials: C
authors.lastname: Di Rocco
mesh_terms: D000236:Adenoma / Q000601:surgery; D000293:Adolescent; D020863:Central Nervous System Cysts / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D044583:Neuroendoscopy / Q000379:methods*; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications; D012658:Sella Turcica / Q000601:surgery*