title: Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione.
abstract: The first synthesis of isaindigotidione has been developed utilizing a reaction sequence including an asymmetric rhodium-catalyzed 1,4-conjugate addition, an intramolecular aldol reaction, and a lactamization.
authors.affiliation: Laboratory of Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.
authors.forename: Malik
authors.initials: M
authors.lastname: Hellal
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Cuny
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D002384:Catalysis; D007212:Indolizines / Q000138:chemical synthesis*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D007212:Indolizines; D011804:Quinolines; C555152:isaindigotidione