title: The expanding world of small molecule microarrays.
abstract: Speed and throughput are vital ingredients for discovery-driven, "-omics" research. The small molecule microarray is one such platform, which delivers phenomenal screening throughput and capabilities. The concept at the heart of the technology is elegant, yet simple: by presenting large collections of molecules at a high density on a flat surface, one is able to interrogate them quickly and conveniently, evaluating all possible interactions in a single step. SMMs have, over the last decade, been established as a robust platform for screening, lead discovery, and molecular characterization. In this chapter, we describe the ways in which microarrays have been constructed and applied, focusing on the practical challenges faced when designing and performing SMM experiments. This is written as an introduction for new readers to the field, explaining the key principles and laying the foundation for the chapters that follow.
authors.affiliation: DSO National Laboratories, Defence Medical and Environmental Research Institute, Singapore, Singapore.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D020650:Combinatorial Chemistry Techniques; D055808:Drug Discovery; D046228:Microarray Analysis / Q000379:methods*; D055616:Microtechnology; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D054852:Small Molecule Libraries