title: Molecular epidemiology of PRRSV: a phylogenetic perspective.
abstract: Since its first discovery two decades ago, porcine reproductive and respiratory syndrome virus (PRRSV) has been the subject of intensive research due to its huge impact on the worldwide swine industry. Thanks to the phylogenetic analyses, much has been learned concerning the genetic diversity and evolution history of the virus. In this review, we focused on the evolutionary and epidemiological aspects of PRRSV from a phylogenetic perspective. We first described the diversity and transmission dynamics of Type 1 and 2 PRRSV, respectively. Then, we focused on the more ancient evolutionary history of PRRSV: the time of onset of all existing PRRSV and an origin hypothesis were discussed. Finally, we summarized the results from previous recombination studies to assess the potential impact of recombination on the virus epidemiology.
authors.affiliation: School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
authors.forename: Mang
authors.initials: M
authors.lastname: Shi
authors.forename: Tommy Tsan-Yuk
authors.initials: TT
authors.lastname: Lam
authors.forename: Chung-Chau
authors.initials: CC
authors.lastname: Hon
authors.forename: Raymond Kin-Hei
authors.initials: RK
authors.lastname: Hui
authors.forename: Kay S
authors.initials: KS
authors.lastname: Faaberg
authors.forename: Trevor
authors.initials: T
authors.lastname: Wennblom
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murtaugh
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stadejek
authors.forename: Frederick Chi-Ching
authors.initials: FC
authors.lastname: Leung
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D019143:Evolution, Molecular; D014644:Genetic Variation; D017720:Molecular Epidemiology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D013552:Swine
chemical_list: D012367:RNA, Viral