title: Claudin-11 expression increased in spermatogenic defect in human testes.
abstract: Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis.
authors.affiliation: Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, South Korea.
authors.forename: Won Heum
authors.initials: WH
authors.lastname: Nah
authors.forename: Jae Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Hyun Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Nam Cheol
authors.initials: NC
authors.lastname: Park
authors.forename: Myung Chan
authors.initials: MC
authors.lastname: Gye
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002450:Cell Communication / Q000502:physiology; D057167:Claudins; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D012708:Sertoli Cells / Q000473:pathology / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology; D013737:Testis / Q000098:blood supply / Q000473:pathology / Q000502:physiology; D019108:Tight Junctions / Q000502:physiology
chemical_list: C120453:CLDN11 protein, human; D057167:Claudins; D009419:Nerve Tissue Proteins