title: Management of recurrent Cushing's disease.
abstract: The management of patients with Cushing's disease remains a major challenge. The remission rate for initial transsphenoidal surgery is reported as 69-94% while the recurrence rate following initially successful transsphenoidal surgery is 2-27%. Treatment options for Cushing's disease after failed initial therapy or recurrence include repeat transsphenoidal surgery, radiotherapy, medical therapy and bilateral adrenalectomy. Management options following unsuccessful initial surgery or recurrence are presented and discussed.
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia. simon.liubinas@gmail.com
authors.forename: Simon V
authors.initials: SV
authors.lastname: Liubinas
authors.forename: Lana Del
authors.initials: LD
authors.lastname: Porto
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000628:therapy*; D003480:Cushing Syndrome / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D007016:Hypophysectomy; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis / Q000628:therapy*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000628:therapy*; D012008:Recurrence; D016896:Treatment Outcome