Plasma levels of MCP-1 and adiponectin in obstructive sleep apnea syndrome.
OBJECTIVE
To evaluate the correlation between concentrations of the proinflammatory cytokines monocyte chemotactic protein 1 (MCP-1), adiponectin, interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor (TNF) and patients with obstructive sleep apnea syndrome (OSAS). Repeated apnea attacks in patients with OSAS constitute a hypoxic condition, which induces tissue inflammation by mediation of these proinflammatory cytokines.


METHODS
Radioimmunoassay analyses of nonrandomized controlled trial.


METHODS
University-affiliated tertiary care hospital.


METHODS
The study population comprised 59 patients who underwent the polysomnography.


METHODS
Serum concentrations of MCP-1, adiponectin, IL-6, IL-8, and TNF, as well as body mass index and polysomnographic data, including apnea-hypopnea index (AHI) and lowest oxygen saturation.


RESULTS
The mean (SD) plasma level of MCP-1 in serum was increased in all patients with OSAS (P < .001), while adiponectin level was decreased in the patients with severe OSAS (6.88 [1.78] μg/mL) compared with normal controls (8.90 [2.63] μg/mL) (P = .006). Serum concentrations of IL-6, IL-8, and TNF did not exhibit any differences between patients with OSAS and normal controls. The correlation coefficient between plasma MCP-1 level and AHI was 0.62 and between adiponectin level and AHI was 0.66.


CONCLUSIONS
Our results suggest that plasma MCP-1 and adiponectin levels were different between patients with OSAS and normal controls. Adiponectin and MCP-1 may be prognostic factors for comparing patients with OSAS before and after treatment.
Kim
Joohwan
J
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Yeongdeungpo-gu, Seoul 150-713, Korea.
Lee
Chang Hoon
CH
Park
Chan Soon
CS
Kim
Byung Guk
BG
Kim
Soo Whan
SW
Cho
Jin Hee
JH
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D017286:Polysomnography; D011863:Radioimmunoassay; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D052242:Adiponectin; D018932:Chemokine CCL2; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha