title: Clinical outcomes of an integrated treatment for depression and substance use disorders.
abstract: The authors compared longitudinal treatment outcomes for depressed substance-dependent veterans (N = 206) assigned to integrated cognitive-behavioral therapy plus standard pharmacotherapy (ICBT + P) or 12-step facilitation therapy plus standard pharmacotherapy (TSF + P). Drug and alcohol involvement and depressive symptomology were measured at intake and at 3-month intervals during treatment and up to 1 year posttreatment. Participants in both treatment conditions showed decreased depression and substance use from intake. ICBT + P participants maintained improvements in substance involvement over time, whereas TSF + P participants had more rapid increases in use in the months following treatment. Decreases in depressive symptoms were more pronounced for TSF + P than ICBT + P in the 6 months posttreatment. Within both treatment groups, higher attendance was associated with improved substance use and depression outcomes over time. Initial levels of depressive symptomology had a complex predictive relationship with long-term depression outcomes. Early treatment response predicted long-term substance use outcomes for a portion of the sample. Although both treatments were associated with improvements in substance use and depression, ICBT + P may lead to more stable substance use reductions compared with TSF + P.
authors.affiliation: Department of Psychiatry, San Diego State University, San Diego, California, USA.
authors.forename: Katherine P
authors.initials: KP
authors.lastname: Lydecker
authors.forename: Susan R
authors.initials: SR
authors.lastname: Tate
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Cummins
authors.forename: John
authors.initials: J
authors.lastname: McQuaid
authors.forename: Eric
authors.initials: E
authors.lastname: Granholm
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Brown
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D011615:Psychotherapy, Group; D019966:Substance-Related Disorders / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents