title: Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: a retrospective analysis of 352 cases after bilateral neck dissection.
abstract: BACKGROUND
  The decision whether to perform an elective neck dissection in patients with head and neck squamous cell carcinoma (HNSCC) and clinically negative lymph nodes (cN0) is made based on the probability of micrometastases in the neck for the given subsite and size of the primary. To date there is limited information about contralateral and bilateral cervical lymph node metastases of oropharyngeal carcinoma.
  
  
  METHODS
  A retrospective chart review was performed of 352 patients with oropharyngeal SCC who received a bilateral neck dissection. The frequency of histologically unveiled bilateral neck metastases was determined.
  
  
  RESULTS
  Carcinomas of the tonsillar fossa starting with a T2 classification and carcinomas of the soft palate, base of tongue, and pharyngeal wall at any stage showed a high frequency of bilateral metastases.
  
  
  CONCLUSIONS
  Bilateral neck dissection should be recommended for all but T1 and selected cases of T2 carcinomas of the tonsillar fossa.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, Munich, Germany. bernhard.olzowy@med.uni-muenchen.de
authors.forename: Bernhard
authors.initials: B
authors.lastname: Olzowy
authors.forename: Yulia
authors.initials: Y
authors.lastname: Tsalemchuk
authors.forename: Klaus-Juergen
authors.initials: KJ
authors.lastname: Schotten
authors.forename: Oliver
authors.initials: O
authors.lastname: Reichel
authors.forename: Ulrich
authors.initials: U
authors.lastname: Harréus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D017558:Elective Surgical Procedures / Q000379:methods; D005260:Female; D005858:Germany / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies