title: The change of corrin-amides to carboxylates leads to altered structures of the B12-responding btuB riboswitch.
abstract: By applying four different acid derivatives of vitamin B(12), we demonstrate that the H-bonding pattern and the electrostatic environment provided by each side chain of the corrin ring are crucial for the correct structural rearrangement of the btuB riboswitch of E. coli.
authors.affiliation: Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: Sofia
authors.initials: S
authors.lastname: Gallo
authors.forename: Stefan
authors.initials: S
authors.lastname: Mundwiler
authors.forename: Roger
authors.initials: R
authors.lastname: Alberto
authors.forename: Roland K O
authors.initials: RK
authors.lastname: Sigel
mesh_terms: D000577:Amides / Q000737:chemistry*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D002264:Carboxylic Acids / Q000737:chemistry*; D045728:Corrinoids / Q000737:chemistry*; D004926:Escherichia coli / Q000737:chemistry* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D015394:Molecular Structure; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D055672:Static Electricity; D014805:Vitamin B 12 / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000577:Amides; D001425:Bacterial Outer Membrane Proteins; C044592:BtuB protein, E coli; D002264:Carboxylic Acids; D045728:Corrinoids; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C473700:corrin; D012313:RNA; D014805:Vitamin B 12