title: A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells.
abstract: Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action.
authors.affiliation: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, PR China.
authors.forename: Menghua
authors.initials: M
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Yuting
authors.initials: Y
authors.lastname: Fan
authors.forename: Palma
authors.initials: P
authors.lastname: Rocchi
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Juan L
authors.initials: JL
authors.lastname: Iovanna
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology*; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D009705:Nucleosides; D014230:Triazoles; D003841:Deoxycytidine; D000093542:Gemcitabine