title: Total synthesis of chivosazole F.
abstract: The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.
authors.affiliation: Centre for Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Schneiderberg 1b, D-30167 Hannover, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Brodmann
authors.forename: Dominic
authors.initials: D
authors.lastname: Janssen
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; C547318:chivosazole F