title: Dopamine agonists and Othello's syndrome.
abstract: BACKGROUND
  Othello's syndrome (OS) is a delusion of infidelity. We describe seven cases of OS in Parkinson's disease (iPD) patients using dopamine agonists.
  
  
  METHODS
  We searched the Mayo Clinic Medical Records System to identify all patients with OS. Clinical data abstracted include sex, age of onset of iPD, age of onset of OS, medications, effect of discontinuing the dopamine agonist, neuroimaging, and comorbidities.
  
  
  RESULTS
  Seven non-demented iPD patients with dopamine agonist implementation time locked to the development and resolution of OS are reported. The average age of iPD onset was 46.6 years (Standard deviation: 5.0 years), and OS onset was 53.7 years (7.1 years). All seven patients had significant marital conflict as a result of the delusions.
  
  
  CONCLUSIONS
  OS can be associated with dopamine agonist use and can lead to serious consequences. Dopamine agonist cessation eliminates the delusion of infidelity and should be the first treatment option.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 1st Street SW Rochester, MN 55905, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Graff-Radford
authors.forename: J Eric
authors.initials: JE
authors.lastname: Ahlskog
authors.forename: James H
authors.initials: JH
authors.lastname: Bower
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects; D052160:Benzothiazoles / Q000009:adverse effects; D003702:Delusions / Q000139:chemically induced* / Q000523:psychology*; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005715:Gambling / Q000523:psychology; D006801:Humans; D008297:Male; D008393:Marriage; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D000077487:Pramipexole; D013577:Syndrome
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D018491:Dopamine Agonists; D000077487:Pramipexole