[Frequency of micronuclei in reticulocytes of male mice exposed to bisphenol A and to a combination of x-rays and bisphenol A].
The aim of the study was to estimate the effects of bisphenol A and combined exposure to X-rays and bisphenol A on the induction of micronuclei in the blood and bone marrow reticulocytes. Pzh:Sfis male mice were irradiated (0.05 Gy and 0.10 Gy) or/and treated with bisphenol A (5 mg/kg mc, 10 mg/kg mc, 15 mg/kg mc, 20 mg/kg mc, 40 mg/kg mc) or exposed to combination of both (0.05 Gy + 5 mg/kg mc BPA lub 0.10 Gy + 10 mg/kg mc BPA) for 2 weeks. Bisphenol A as well as ionizing radiation alone stimulated induction of micronuclei in peripheral blood and bone marrow reticulocytes. Combined exposure of X-rays and bisphenol A induced higher frequency of micronuclei compared to effect produced by BPA alone. Sometimes, especially after combined exposure to low doses of both agents, observed effects enhanced that obtained following exposure to X-rays alone. Ionising radiation is probably the agent which decided about damage and/or unequal distribution of chromosomes following combined exposure together with bisphenol A, which seems to be weak mutagen.
Dobrzyńska
Małgorzata M
MM
Zakład Ochrony Radiologicznej i Radiobiologii, Narodowy Instytut Zdrowia Publicznego-Państwowy Zakład Higieny, Warszawa. mdobrzynska@pzh.gov.pl
Radzikowska
Joanna
J
D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D001559:Benzhydryl Compounds; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000528:radiation effects; D010636:Phenols / Q000633:toxicity*; D012156:Reticulocytes / Q000187:drug effects* / Q000528:radiation effects*; D014916:Whole-Body Irradiation; D014965:X-Rays / Q000009:adverse effects*; D000098826:Bisphenol A Compounds
D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D009153:Mutagens; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds