Resolution of surgically created three-wall intrabony defects in implants using three different biomaterials: an in vivo study.
OBJECTIVE
To histomorphometrically analyze bone formation on amorphous calcium phosphate (ACP), micro-macroporous biphasic calcium phosphate (MBCP), and freeze-dried bone allograft (FDBA) in three-wall defects adjacent to structured surface with calcium phosphate nanocoating implants in dogs.


METHODS
Five male mixed-breed dogs were used in this study. The premolars and molars were extracted on both sides of the mandible. Eight weeks after extraction, four implants were submerged on each side of the mandible. Three-wall intrabony defects (5 × 3 × 3 mm) were surgically created adjacent to the implants before installation. No grafts were placed in the control group. At the experimental sites, each intrabony defect was grafted with either ACP, MBCP, or FDBA. The dogs were sacrificed after 12 weeks, and histological and histomorphometrical analyses of the implant sites were performed.


RESULTS
All of the three experimental groups exhibited defect resolution and osseointegration that showed a statistically significant difference compared with the control group in terms of remaining defect depth and bone-to-implant contact (BIC). However, there were no statistical significances among the three experimental groups. MBCP had the highest BIC (63.57 ± 21.57%), followed by ACP and FDBA. The control group showed the least bone area and the greatest remaining defect depth.


CONCLUSIONS
Grafts with the synthetic biomaterials ACP and MBCP showed bone regeneration that was similar to FDBA in surgically created three-wall intrabony defects adjacent to implants. Within the limitations of this study, it can be concluded that ACP and MBCP synthetic biomaterials are as effective as FDBA at osteoconduction.
Choi
Jung-Yoo
JY
Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seodaemun-gu, Seoul, Korea.
Jung
Ui-Won
UW
Lee
In-Seop
IS
Kim
Chang-Sung
CS
Lee
Yong-Keun
YK
Choi
Seong-Ho
SH
D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D017267:Dental Prosthesis Design; D004285:Dogs; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D008336:Mandibular Diseases / Q000473:pathology / Q000601:surgery*; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D020390:Tooth Socket / Q000473:pathology / Q000601:surgery; D014184:Transplantation, Homologous
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; C519480:amorphous calcium phosphate; C020243:calcium phosphate; D014025:Titanium