An influenza B outbreak during the 2007/2008 winter among appropriately immunized elderly people living in a nursing home.
The study evaluated the immunogenicity and efficacy of a trivalent subunit MF59-adjuvanted influenza vaccine (A/Wisconsin/67/05 (H3N2), A/Solomon Islands/3/06 (H1N1) and B/Malaysia/2506/04) in preventing serologically diagnosed infections in a group of 67 institutionalized elderly volunteers during 2007/2008 winter, characterized by co-circulation of drifted A/H3N2, A/H1N1 and B influenza viruses. Influenza vaccination induced a significant increase in the amounts of hemagglutination inhibiting antibodies, both against the vaccine and the epidemic drifted strains. However, vaccination did not prevent the circulation of the new drifted influenza B virus (B/Florida/4/06-like), belonging to the B/Yamagata/16/88-lineage, antigenically and genetically distinct from B/Victoria/2/87-lineage viruses from which the vaccine B strain was derived.
Camilloni
B
B
Department of Medical and Surgical Specialities and Public Health, University of Perugia, Perugia, Italy.
Neri
M
M
Lepri
E
E
Basileo
M
M
Sigismondi
N
N
Puzelli
S
S
Donatelli
I
I
Iorio
A M
AM
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000235:genetics; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007114:Immunization; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000235:genetics; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification / Q000235:genetics; D009981:Influenza B virus / Q000145:classification / Q000235:genetics; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D009735:Nursing Homes; D010802:Phylogeny; D011136:Polysorbates / Q000008:administration & dosage; D013185:Squalene / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; C089950:MF59 oil emulsion; D011136:Polysorbates; D013185:Squalene