Metabolites from the fungus Phoma sp. 7210, associated with Aizoon canariense.
A new metabolite, 3,16-diketoaphidicolan (1), was isolated together with four known compounds: aphidicolin (2), 17-acetyl-aphidicolin (3), (+)-eupenoxide (4), and phomoxanthone A (5) from the endophytic fungus Phoma sp. The structure of the new compound 1 was determined by spectroscopic methods (mainly extensive 1D and 2D NMR experiments and by mass spectral measurements) and confirmed by X-ray crystallography. Its absolute configuration was assigned by means of the solid-state CD/TDDFT approach comparing the solid-state CD spectrum with the TDDFT-calculated one on the X-ray geometry.
Dai
Jingqiu
J
Department of Chemistry, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany.
Hussain
Hidayat
H
Dräger
Siegfried
S
Schulz
Barbara
B
Kurtán
Tibor
T
Pescitelli
Gennaro
G
Flörke
Ulrich
U
Krohn
Karsten
K
D016590:Aphidicolin / Q000031:analogs & derivatives* / Q000737:chemistry; D001203:Ascomycota / Q000378:metabolism*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000382:microbiology*
C552821:3,16-diketoaphidicolan; D016590:Aphidicolin