Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer.
Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut.
Feagins
Linda A
LA
Divisions of Gastroenterology and Hepatology, VA North Texas Health Care System, and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. LindaA.Feagins@va.gov
D000818:Animals; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D003092:Colitis / Q000276:immunology* / Q000473:pathology; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D058504:Th17 Cells / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000276:immunology*
D016212:Transforming Growth Factor beta