Asymmetric synthesis of indolines by catalytic enantioselective reduction of 3H-indoles.
A highly enantioselective metal-free reduction of 3H-indoles has been developed. This Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source constitutes an efficient method for the synthesis of various optically active indolines with high enantioselectivities.
Rueping
Magnus
M
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany. magnus.rueping@rwth-aachen.de
Brinkmann
Claus
C
Antonchick
Andrey P
AP
Atodiresei
Iuliana
I