title: Signaling defects and the nuclear envelope in progeria.
abstract: Hutchinson-Gilford progeria syndrome is a rare childhood genetic disorder with features of accelerated aging. In this issue, Hernandez et al. observe decreased Wnt signaling and extracellular matrix gene expression in a murine model of the disease, suggesting potential therapeutic strategies and further emphasizing the nuclear envelope's role in signal transduction.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Antoine
authors.initials: A
authors.lastname: Muchir
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Worman