Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.
T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen-presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the cross-talk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling.
Lasserre
Rémi
R
Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France. remi.lasserre@pasteur.fr
Alcover
Andrés
A
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction
D011948:Receptors, Antigen, T-Cell