title: Nutrient patterns and risk of breast cancer in Uruguay.
abstract: OBJECTIVE
  To explore the role of nutrient patterns in the etiology of breast cancer (BC) among Uruguayan women.
  
  
  METHODS
  A principal component analysis was conducted. The study included 442 newly diagnosed cases of BC and 442 hospitalized controls.
  
  
  RESULTS
  Two dietary patterns derived from factor analysis and were labeled as high-meat and antioxidants patterns. Whereas the high-meat pattern was directly associated with BC risk (OR for the highest versus the lowest quartile = 3.50, 95 % CI 1.94-6.30, p-value for trend <0.0001), the antioxidants pattern displayed a protective effect (OR=0.44, 95 % CI 0.27-0.74). Its negative association was stronger for postmenopausal than for premenopausal women (OR=0.63, 95% CI 0.51-0.79 vs. OR=0.89, 95% CI 0.50-1.56, respectively). Both strata were heterogeneous (p=0.004). The high-meat pattern was more associated with BC risk among patients with family history of BC compared with participants without it, but results did not differ by histology. In contrast, the antioxidants pattern was more associated with non-ductal cancers (OR=0.50 [95 % CI 0.35-0.69]) than with ductal cancers (OR=0.72, 95 % CI 0.58-0.88, heterogeneity p-value=0.03).
  
  
  CONCLUSIONS
  Results support an association between the high-meat and antioxidant dietary patterns and BC risk. Furthermore, findings suggest that gene-environmental interactions may be important in BC etiology.
authors.affiliation: Instituto de Radiología y Centro de Lucha Contra el Cáncer, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay. alronco@gmail.com
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Stefani
authors.forename: Dagfinn
authors.initials: D
authors.lastname: Aune
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Gisele
authors.initials: G
authors.lastname: Acosta
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000209:etiology* / Q000517:prevention & control*; D018270:Carcinoma, Ductal, Breast / Q000209:etiology / Q000517:prevention & control; D018275:Carcinoma, Lobular / Q000209:etiology / Q000517:prevention & control; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D006801:Humans; D015994:Incidence; D008460:Meat / Q000009:adverse effects*; D008593:Menopause; D008875:Middle Aged; D025341:Principal Component Analysis; D011379:Prognosis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D015996:Survival Rate; D014583:Uruguay
chemical_list: D000975:Antioxidants