title: The influence of diabetes on degree of abdominal aortic aneurysm tissue inflammation.
abstract: Abdominal aortic aneurysm (AAA) progression and disease resistance are related to transmural degenerative processes and an inflammatory infiltration (INF). Diabetes is associated with low prevalence and growth rate of AAA. We sought to characterize INF in established AAA (INFAAA), in diabetic patients. From 89 male patients aged 52 to 83 years, aneurysm specimens obtained at open asymptomatic nonruptured AAA repair were graded for INF and immunostained using antibodies against T-lymphocytes (CD3) and macrophages (CD68). Diabetic patients had an odds ratio (OR) 3.8, 95% confidence interval ([CI] 1.14-12.96), P = .03, of experiencing above-median INFAAA. These associations were affected by serum glucose (SG) levels (OR 3.6, 95% CI [0.72-18.77]; P = .1). Macrophage subpopulations higher in diabetic patients (1.44 ± 0.78 versus 0.98 ± 0.76; P = .02) were correlated with SG (r = .21, P = .044). Abdominal aortic aneurysms in diabetic patients are associated with higher INF. Macrophage densities are correlated with SG.
authors.affiliation: Vascular Surgical Unit, 2nd Surgical Department, Aretaeion Hospital, Medical School, University of Athens, Greece. arapoglu@aretaieio.uoa.gr
authors.forename: Vassilis
authors.initials: V
authors.lastname: Arapoglou
authors.forename: Agathi
authors.initials: A
authors.lastname: Kondi-Pafiti
authors.forename: Demetrios
authors.initials: D
authors.lastname: Rizos
authors.forename: Eleni
authors.initials: E
authors.lastname: Carvounis
authors.forename: Matrona
authors.initials: M
authors.lastname: Frangou-Plemenou
authors.forename: Thomas
authors.initials: T
authors.lastname: Kotsis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Katsenis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001012:Aorta, Abdominal / Q000276:immunology*; D017544:Aortic Aneurysm, Abdominal / Q000276:immunology*; D001025:Aortitis / Q000276:immunology*; D001786:Blood Glucose / Q000378:metabolism; D017252:CD3 Complex / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000276:immunology*; D018450:Disease Progression; D006115:Greece; D006801:Humans; D016015:Logistic Models; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001786:Blood Glucose; D017252:CD3 Complex; C067980:CD68 antigen, human; D000097382:CD68 Molecule