title: Schistosomiasis coinfection in children influences acquired immune response against Plasmodium falciparum malaria antigens.
abstract: BACKGROUND
  Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children.
  
  
  METHODS
  Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group.
  
  
  CONCLUSIONS
  Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.
authors.affiliation: Inserm Unité 547, Institut Pasteur de Lille, Lille, France. tamsird@yahoo.fr
authors.forename: Tamsir O
authors.initials: TO
authors.lastname: Diallo
authors.forename: Franck
authors.initials: F
authors.lastname: Remoue
authors.forename: Lobna
authors.initials: L
authors.lastname: Gaayeb
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Schacht
authors.forename: Nicole
authors.initials: N
authors.lastname: Charrier
authors.forename: Dick
authors.initials: D
authors.lastname: De Clerck
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Dompnier
authors.forename: Sophie
authors.initials: S
authors.lastname: Pillet
authors.forename: Olivier
authors.initials: O
authors.lastname: Garraud
authors.forename: Abdoulaye A
authors.initials: AA
authors.lastname: N'Diaye
authors.forename: Gilles
authors.initials: G
authors.lastname: Riveau
mesh_terms: D000293:Adolescent; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D016207:Cytokines / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D008297:Male; D020066:Merozoite Surface Protein 1 / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology* / Q000502:physiology; D012548:Schistosoma haematobium / Q000276:immunology / Q000502:physiology; D012553:Schistosomiasis haematobia / Q000150:complications / Q000276:immunology* / Q000469:parasitology
chemical_list: D000909:Antibodies, Helminth; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D016207:Cytokines; D020066:Merozoite Surface Protein 1