title: Effect of bilateral oophorectomy on wound healing of the rabbit vagina.
abstract: We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.
authors.affiliation: Division of Urogynecology and Reconstructive Pelvic Surgery, Carmel Medical Center, Technion University Rappaport Faculty of Medicine, Haifa, Israel. yabramov@012.net.il
authors.forename: Yoram
authors.initials: Y
authors.lastname: Abramov
authors.forename: Antonio R
authors.initials: AR
authors.lastname: Webb
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Botros
authors.forename: Roger P
authors.initials: RP
authors.lastname: Goldberg
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Ameer
authors.forename: Peter K
authors.initials: PK
authors.lastname: Sand
mesh_terms: D000818:Animals; D005260:Female; D010052:Ovariectomy / Q000009:adverse effects* / Q000379:methods; D011817:Rabbits; D011897:Random Allocation; D020127:Recovery of Function / Q000502:physiology*; D014621:Vagina / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*