Factors associated with postmenopausal osteoporosis: a case-control study of Belgrade women.
The aim of this study was to investigate factors related to osteoporosis in postmenopausal women in Belgrade. A case-control study was conducted during 2006-2007. The study group consisted of 100 newly diagnosed osteoporosis patients and 100 age-matched controls (± 2 years). The inclusion criteria for the case group were newly diagnosed osteoporosis confirmed by dual-energy X-ray absorptiometry of the lumbar spine and being menopausal (at least 2 years of amenorrhea). The inclusion criteria for the control group were postmenopausal women with confirmed normal bone mineral density of the lumbar spine by dual-energy X-ray absorptiometry. All study participants were interviewed using a structured questionnaire. Univariate and multivariate logistic regression analyses were used. The following factors were significantly independently related to osteoporosis: low body weight (P < 0.001), thin constitution in childhood (P = 0.002), history of previous fracture (P = 0.033), menopause at age <47 years (P < 0.001), family history of fracture (P = 0.005), and less frequent consumption of cheese (P = 0.027) and fish (P = 0.020). The majority of factors identified may be modifiable and could be influenced to prevent postmenopausal osteoporosis.
Grgurevic
Anita
A
Institute of Epidemiology, School of Medicine, University of Belgrade, Belgrade, Serbia. anitag@beotel.net
Gledovic
Zorana
Z
Vujasinovic-Stupar
Nada
N
D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D050723:Fractures, Bone; D020022:Genetic Predisposition to Disease; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000209:etiology* / Q000517:prevention & control; D012307:Risk Factors; D055771:Serbia; D011795:Surveys and Questionnaires; D013851:Thinness / Q000150:complications*