title: Intraabdominal and retroperitoneal soft-tissue sarcomas--outcome of surgical treatment in primary and recurrent tumors.
abstract: BACKGROUND
  Surgery is the only curative treatment for intraabdominal and retroperitoneal sarcoma (IaRS). Little is known about how to treat patients with recurrence. We here report the outcome in primary and recurrent sarcoma treated at the Sarcoma Center in Aarhus, Denmark.
  
  
  METHODS
  All patients evaluated for IaRS from June 1998 to May 2008 were enrolled and data on symptoms, signs, means of diagnosis, extent of surgery, perioperative complications, mortality and long time survival were registered. Primary and first-recurrence sarcomas were analyzed separately.
  
  
  RESULTS
  Sixty-five of 73 primary and 22 of 28 first-recurrence IaRS had surgery. Fifty-three (82%) and 11 (50%) patients achieved radical R0 resection. Age and radicality of surgery were independent predictors of death, while recurrence of sarcoma was not. Perioperative mortality was 2.3%. 5-year survival was 70.2% for primary and 51.8% for first-recurrent sarcomas. However, patients with radical surgery had 5-year survival of over 70% in both the primary and recurrent group.
  
  
  CONCLUSIONS
  The radicality of surgery is the most important prognostic factor. Patients with recurrence have an equally good prognosis as those with primary sarcoma if radicality is achieved and such surgery should not be considered only as a palliative effort.
authors.affiliation: Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Ane S
authors.initials: AS
authors.lastname: Sogaard
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Laurberg
authors.forename: Mette
authors.initials: M
authors.lastname: Sorensen
authors.forename: Ole S
authors.initials: OS
authors.lastname: Sogaard
authors.forename: Pal
authors.initials: P
authors.lastname: Wara
authors.forename: Peter
authors.initials: P
authors.lastname: Rasmussen
authors.forename: Soren
authors.initials: S
authors.lastname: Laurberg
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D001706:Biopsy; D003718:Denmark / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007813:Laparotomy / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome