Dragmacidin E synthesis studies. Preparation of a model heptacyclic core structure.
The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target.
Feldman
Ken S
KS
Chemistry Department, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. ksf@chem.psu.edu
Ngernmeesri
Paiboon
P
D001386:Azides / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D015394:Molecular Structure
D001386:Azides; D006576:Heterocyclic Compounds, 4 or More Rings; D026121:Indole Alkaloids; C512386:dragmacidin E