title: ArrayTrack: a free FDA bioinformatics tool to support emerging biomedical research--an update.
abstract: ArrayTrack is a Food and Drug Administration (FDA) bioinformatics tool that has been widely adopted by the research community for genomics studies. It provides an integrated environment for microarray data management, analysis and interpretation. Most of its functionality for statistical, pathway and gene ontology analysis can also be applied independently to data generated by other molecular technologies. ArrayTrack has been undergoing active development and enhancement since its inception in 2001. This review summarises its key functionalities, with emphasis on the most recent extensions in support of the evolving needs of FDA's research programmes. ArrayTrack has added capability to manage, analyse and interpret proteomics and metabolomics data after quantification of peptides and metabolites abundance, respectively. Annotation information about single nucleotide polymorphisms and quantitative trait loci has been integrated to support genetics-related studies. Other extensions have been added to manage and analyse genomics data related to bacterial food-borne pathogens.
authors.affiliation: Z-Tech Corporation, an ICF International Company at the National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA. Zhihua.xu@fda.hhs.gov
authors.forename: Joshua
authors.initials: J
authors.lastname: Xu
authors.forename: Reagan
authors.initials: R
authors.lastname: Kelly
authors.forename: Hong
authors.initials: H
authors.lastname: Fang
authors.forename: Weida
authors.initials: W
authors.lastname: Tong
mesh_terms: D035843:Biomedical Research / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012984:Software; D014481:United States; D014486:United States Food and Drug Administration