title: Oral administration of Aloe vera and honey reduces Walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue.
abstract: Cancer is diagnosed in approximately 11 million people and is responsible for almost 8 million deaths worldwide every year. Research in cancer control has shown the importance of co-adjuvant therapies. Aloe vera may reduce tumour mass and metastasis rates, while honey may inhibit tumour growth. This study verified the influence of Aloe vera and honey on tumour growth and in the apoptosis process by assessing tumour size, the cell proliferation rate (Ki67-LI) and Bax/Bcl-2 expression at 7, 14 and 20 days after Walker 256 carcinoma implant in Wistar rats distributed into two groups: the WA group - tumour-bearing rats that received a gavage with a 670 µL/kg dose of Aloe vera and honey solution daily, and the CW group - tumour-bearing rats which received only a 0.9% NaCl solution. The effect of Aloe vera and honey against tumour growth was observed through a decrease in relative weight (%) and Ki67-LI in tumours from the WA group compared with those from the CW group. The Bax/Bcl-2 ratio increased in tumours from the WA group at all tested timepoints. These data suggest Aloe vera and honey can modulate tumour growth by reducing cell proliferation and increasing apoptosis susceptibility.
authors.affiliation: Laboratory of Nutrition and Cancer, Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas -UNICAMP, Campinas, 13083970, São Paulo, Brazil.
authors.forename: Rebeka
authors.initials: R
authors.lastname: Tomasin
authors.forename: Maria Cristina Cintra
authors.initials: MC
authors.lastname: Gomes-Marcondes
mesh_terms: D000284:Administration, Oral; D000504:Aloe; D000818:Animals; D017209:Apoptosis; D002279:Carcinoma 256, Walker / Q000473:pathology*; D049109:Cell Proliferation; D006722:Honey; D008297:Male; D051381:Rats; D017208:Rats, Wistar