Pd(0)-Catalyzed carbonylation of 1,1-dichloro-1-alkenes, a new selective access to Z-α-chloroacrylates.
A novel and fully chemo- and stereoselective three component strategy leading to Z-α-chloroacrylates by a Pd(0)-catalyzed reaction of CO (1 atm) with 1,1-dichloro-1-alkenes and various alcohols is disclosed. This catalytic approach compares favourably with the Wittig type strategies as α-chloroacrylates of pure Z configuration are obtained in high yield.
Arthuis
Martin
M
CNRS, Institut de Chimie des Substances Naturelles (ICSN), UPR 2301, Avenue de la Terrasse, 91198, Gif-sur-Yvette, France.
Lecup
Anne
A
Roulland
Emmanuel
E
D000179:Acrylates / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
C502742:2-chloroacrylic acid; D000179:Acrylates; D000475:Alkenes; D010165:Palladium