title: The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy.
abstract: BACKGROUND
  Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The "hypertriglyceridemic waist" phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy.
  
  
  METHODS
  Plasma triglycerides and waist girth were measured at 11-14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24-28 weeks of gestation.
  
  
  RESULTS
  A waist girth greater than 85 cm in combination with a triglyceride level ≥ 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose ≥ 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02).
  
  
  CONCLUSIONS
  Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance.
authors.affiliation: Department of Medicine, Université de Montréal, Montreal, Canada. diane.brisson@ecogene21.org
authors.forename: Diane
authors.initials: D
authors.lastname: Brisson
authors.forename: Patrice
authors.initials: P
authors.lastname: Perron
authors.forename: Simon-Pierre
authors.initials: SP
authors.lastname: Guay
authors.forename: Daniel
authors.initials: D
authors.lastname: Gaudet
authors.forename: Luigi
authors.initials: L
authors.lastname: Bouchard
mesh_terms: D000293:Adolescent; D000328:Adult; D016640:Diabetes, Gestational / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications; D008423:Maternal Age; D009765:Obesity / Q000150:complications; D010641:Phenotype; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000503:physiopathology; D011261:Pregnancy Trimester, First / Q000378:metabolism / Q000502:physiology; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult