Reversible escitalopram-induced hypothyroidism.
Some drugs can cause alterations in the concentration of thyroid hormones in blood even without clinical signs of dysfunction or pathology of the thyroid gland. Apart from the well-known relationship between depression and hypothalamic-pituitary-thyroid (HPT) axis, and the impact of selective serotonin reuptake inhibitors (SSRIs) on thyroid indices, hypothyroidism is a very rare adverse effect of SSRI treatment. However, the case presented here demonstrates that escitalopram may have the potential to induce hypothyroidism without any significant clinical signs and symptoms. Therefore, the possibility of SSRI-induced asymptomatic hypothyroidism presented here may help clinicians in this regard.
Eker
Salih Saygin
SS
Department of Psychiatry, Uludag University Medical Faculty, 16059 Bursa, Turkey. saygineker@yahoo.com
Akkaya
Cengiz
C
Ersoy
Canan
C
Sarandol
Asli
A
Kirli
Selcuk
S
D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use / Q000633:toxicity*; D015283:Citalopram / Q000627:therapeutic use / Q000633:toxicity*; D003866:Depressive Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D050031:Hashimoto Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines / Q000627:therapeutic use; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use
D018687:Antidepressive Agents, Second-Generation; D044005:Tetrahydroisoquinolines; D015283:Citalopram; D013974:Thyroxine; D000077583:Quinapril