Cutaneous phaeohyphomycosis in renal allograft recipients: report of 2 cases and review of the literature.
Dematiaceous molds are increasingly recognized as important human pathogens. We report 2 cases of cutaneous phaeohyphomycosis in renal allograft recipients, caused by Alternaria alternata and Curvularia spp., respectively, which demonstrate the diversity in clinical presentation, the different therapeutic strategies, and the clinical importance of azole antifungal-induced drug-drug interactions with immunosuppressive therapy.
Vermeire
Sylvie E M
SE
Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. sylvie.vermeire@uzleuven.be
de Jonge
Hylke
H
Lagrou
Katrien
K
Kuypers
Dirk R J
DR
D000368:Aged; D000528:Alternaria; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D001203:Ascomycota; D001393:Azoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D007868:Leg Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D016559:Tacrolimus
D000935:Antifungal Agents; D001393:Azoles; D016559:Tacrolimus