Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.
Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age.
Mouchiroud
Laurent
L
UMR, CNRS Université Lyon, Centre Léon Bérard, France.
Molin
Laurent
L
Dallière
Nicolas
N
Solari
Florence
F
D055372:AMP-Activated Protein Kinases / Q000502:physiology; D000375:Aging / Q000187:drug effects; D000818:Animals; D004032:Diet; D002149:Energy Intake; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects*; D008687:Metformin / Q000494:pharmacology*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D000077185:Resveratrol; D020123:Sirolimus / Q000494:pharmacology*; D056564:Sirtuin 1 / Q000502:physiology; D056565:Sirtuin 2 / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology*; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors
D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D013267:Stilbenes; D015534:Trans-Activators; D014157:Transcription Factors; D008687:Metformin; D055372:AMP-Activated Protein Kinases; D056564:Sirtuin 1; D056565:Sirtuin 2; D000077185:Resveratrol; D020123:Sirolimus