title: Synthesis of diheterocyclic compounds based on triazolyl methoxy phenylquinazolines via a one-pot four-component-click reaction.
abstract: A facile and highly efficient method for one-pot four-component synthesis of triazolyl methoxy phenylquinazolines is described. A mixture of aromatic propargylated aldehydes, different azides, 2-aminobenzophenone derivatives, and ammonium acetate were condensed in the presence of catalytic amounts of acidic ionic liquid, 1-methylimidazolium trifluoroacetate, ([Hmim]TFA), and Cu(OAc)(2)/sodium ascorbate to afford the corresponding products in excellent yields. This methodology is highly efficient for structurally diverse azides.
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran. m-dabiri@sbu.ac.ir
authors.forename: Minoo
authors.initials: M
authors.lastname: Dabiri
authors.forename: Peyman
authors.initials: P
authors.lastname: Salehi
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Bahramnejad
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sherafat
mesh_terms: D057930:Click Chemistry / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D011799:Quinazolines