Enantioselective conjugate addition of boronic acids to enones catalyzed by O-monoacyltartaric acids.
We have found that O-monoacyltartaric acids catalyze asymmetric conjugate addition of boronic acids to enones with good enantioselectivity, and the 3,5-di(tert-butyl)benzoyl group provides the best results among the acyl groups examined.
Sugiura
Masaharu
M
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. msugiura@kumamoto-u.ac.jp
Tokudomi
Mirai
M
Nakajima
Makoto
M
D000475:Alkenes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013644:Tartrates / Q000737:chemistry*
D000475:Alkenes; D001897:Boronic Acids; D007659:Ketones; D013644:Tartrates; C029768:tartaric acid