[The role of osteopontin in cardiovascular diseases].
Osteopontin (OPN) is an acid phosphorylated glycoprotein secreted by cells of the immune system, epithelial cells, smooth muscle cells, osteoblasts, osteoclasts, tumor cells and many more. Osteopontin is a multifunctional protein. Due to characteristic molecular structure containing integrin bining domains, OPN can interact with several integrin receptors, thus it play a role in activation, adhesion and migration of many cell types in such processes as inflammation, tissue mineralization and tumor genesis. This broad biological action of osteopontin underlie its presumed role in the pathogenesis of cardiovascular diseases, including atherosclerosis and abdominal aortic aneurysm formation.
Witkiewicz
Wojciech
W
Wojewódzki Szpital Specjalistyczny we Wrocławiu, Ośrodek Badawczo-Rozwojowy.
Czyzewska-Buczyńska
Agnieszka
A
Bałasz
Sebastian
S
Gnus
Jan Janusz
JJ
D002318:Cardiovascular Diseases / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D053495:Osteopontin / Q000737:chemistry / Q000378:metabolism*; D019030:Receptors, Vitronectin / Q000378:metabolism
D019030:Receptors, Vitronectin; D053495:Osteopontin