title: Synthesis, DNA binding and cleavage activity of macrocyclic polyamines bearing mono- or bis-acridine moieties.
abstract: Two acridine-pendant cyclen (1,4,7,10-tetraazacyclododecane) derivatives 1 and 2 were synthesized, and their DNA interactions have been systematically investigated by UV absorption, fluorescence titration, viscosity measurement, DNA melting and gel electrophoresis experiments. The results showed that acridine-cyclen derivatives could bind to DNA in intercalative mode, and bis-acridine 2 has higher DNA binding ability than that of mono-acridine 1. Moreover, both compounds exhibited preferential interactions with G-rich DNA sequences. Their copper(II) complexes could cleave DNA without the existence of other additives under physiological conditions through an oxidative pathway.
authors.affiliation: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Ming-Qi
authors.initials: MQ
authors.lastname: Wang
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Zhang
authors.forename: Qiao-Sen
authors.initials: QS
authors.lastname: Lu
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.forename: Hong-Hui
authors.initials: HH
authors.lastname: Lin
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D000166:Acridines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000166:Acridines; D011073:Polyamines; D004247:DNA