Fucoidan isolated from Laminaria angustata var. longissima induced macrophage activation.
We investigated macrophage activation by fucoidan from Laminaria angustata var. longissima in a murine macrophage cell line, RAW 264.7. The ratio of the chemical composition of the fucoidan was L-fucose:D-galactose:D-glucose:D-xylose:uronic acid:sulfate=1.00:0.54:0.08:0.08:0.64:0.87. The fucoidan induced production of nitric oxide, tumor necrosis factor-α, and interleukin-6 in RAW 264.7 cells. These results indicate that the fucoidan induced macrophage activation.
Teruya
Takeshi
T
Department of Subtropical Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Okinawa, Japan.
Takeda
Shinji
S
Tamaki
Yukihiro
Y
Tako
Masakuni
M
D000276:Adjuvants, Immunologic; D000818:Animals; D000970:Antineoplastic Agents; D002460:Cell Line; D015850:Interleukin-6 / Q000096:biosynthesis; D007795:Laminaria / Q000737:chemistry*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000166:cytology / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D000459:Phaeophyceae; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D015850:Interleukin-6; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; C007789:fucoidan