title: Investigation of 4-piperidinols as novel H3 antagonists.
abstract: Compounds containing a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor. The compounds exhibited up to a 60-fold preference for inhibiting the human H(3) receptor over the mouse and showed a low binding affinity for the hERG channel.
authors.affiliation: Athersys Inc., 3201 Carnegie Ave., Cleveland, OH 44115-2634, USA. andersj12@wyeth.com
authors.forename: James T
authors.initials: JT
authors.lastname: Anderson
authors.forename: Michael
authors.initials: M
authors.lastname: Campbell
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Brunden
authors.forename: John J
authors.initials: JJ
authors.lastname: Harrington
authors.forename: Alain
authors.initials: A
authors.lastname: Stricker-Krongrad
authors.forename: Jianping
authors.initials: J
authors.lastname: Song
authors.forename: Chris
authors.initials: C
authors.lastname: Doucette
authors.forename: Steven
authors.initials: S
authors.lastname: Murphy
authors.forename: Youssef L
authors.initials: YL
authors.lastname: Bennani
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D051638:Ether-A-Go-Go Potassium Channels / Q000187:drug effects; D054828:Histamine H3 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D051379:Mice; D008958:Models, Molecular; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D051638:Ether-A-Go-Go Potassium Channels; D054828:Histamine H3 Antagonists; D007202:Indicators and Reagents; D010880:Piperidines