Molecular correlates of spontaneous activity in non-human primates.
In our monkey model, cortical ARC and BDNF expressions were strongly correlated with spontaneous physical activity. The expressions of ARC and BDNF were inversely correlated with serum CRP levels, suggesting that CRP could be a putative peripheral marker of brain resiliency.
Mitchell
Amanda C
AC
Department of Psychiatry, Vanderbilt University, 8130A MRB III, 465 21st Avenue South, Nashville, TN 37232, USA.
Aldridge
Georgina
G
Kohler
Shawn
S
Stanton
Greg
G
Sullivan
Elinor
E
Garbett
Krassimira
K
Faludi
Gabor
G
Mirnics
Károly
K
Cameron
Judy L
JL
Greenough
William
W
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000378:metabolism; D002097:C-Reactive Protein / Q000096:biosynthesis* / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D008253:Macaca mulatta; D023421:Models, Animal; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000737:chemistry / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor; D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; C092069:activity regulated cytoskeletal-associated protein; D002097:C-Reactive Protein