[Positive sentinel node risk in relation to oestrogen receptors in breast cancer in premenopausal and postmenopausal women].
OBJECTIVE
The influence of the relationship between pre- and post-menopausal stage of patients with breast cancer (BC) and the risk of sentinel lymph node (SLN) metastasis as well as the influence of oestrogen receptor (ER) status within each one of these groups were analyzed.


METHODS
A BC database with 1,388 patients was analysed. Three age groups were studied: A, elderly postmenopausal, 200 patients, ≥ 70 years old; B, younger postmenopausal, 89 patients, 55-69 years old; C, premenopausal, 85 patients, <55 years old. In each group 2 subgroups were analyzed: positive ER and negative ER tumours. Data analysed: SLN-positive patients, non-sentinel node (NSN)-positive patients, non-surgical detections (NSD) and non disease-free (NDF) patients after a follow-up of 52 months.


METHODS
chi-squared test, significance: P ≤ 0.05.


RESULTS
SLN metastasis was significantly (P<0.025) more common in premenopausal than in postmenopausal patients, and within those, mainly in negative ER tumours. Positive-NSN increases slightly in premenopausal patients (exclusively in negative ER tumours). NDF patients are similar in the 3 groups and in all of them it is much more frequent in negative ER tumours.


CONCLUSIONS
SLN metastasis varies significantly according to hormonal state and not according to age, being more frequent in premenopausal patients and mainly in ER negative tumours.
Bajén
M T
MT
Servicio de Medicina Nuclear, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, España. mtbajen@bellvitgehospital.cat
Benítez
A M
AM
Domènech
A
A
Ricart
Y
Y
Mora
J
J
Notta
P
P
Ramal
D
D
Urruticoechea
A
A
Soler
T
T
Martín-Comin
J
J
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology / Q000556:secondary*; D004967:Estrogens; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009376:Neoplasms, Hormone-Dependent / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology*; D017698:Postmenopause; D017697:Premenopause; D015995:Prevalence; D011960:Receptors, Estrogen / Q000032:analysis*; D012189:Retrospective Studies; D012306:Risk; D021701:Sentinel Lymph Node Biopsy
D004967:Estrogens; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen