title: Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification.
abstract: A bombesin derivative was successfully radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Thus, (99m)Tc-HYNIC-Bombesin((7-14)) could be used as an agent for tumor diagnosis.
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
authors.forename: André Luís Branco
authors.initials: AL
authors.lastname: de Barros
authors.forename: Luciene das Graças
authors.initials: Ld
authors.lastname: Mota
authors.forename: Carolina de Aguiar
authors.initials: Cde A
authors.lastname: Ferreira
authors.forename: Mônica Cristina de
authors.initials: MC
authors.lastname: Oliveira
authors.forename: Alfredo Miranda de
authors.initials: AM
authors.lastname: Góes
authors.forename: Valbert Nascimento
authors.initials: VN
authors.lastname: Cardoso
mesh_terms: D000818:Animals; D001001:Anura; D001839:Bombesin / Q000031:analogs & derivatives* / Q000737:chemistry; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging / Q000378:metabolism; D007202:Indicators and Reagents; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D021241:Spectrometry, Mass, Electrospray Ionization; D013667:Technetium; D014018:Tissue Distribution
chemical_list: D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; C555232:technetium 99m HYNIC-bombesin (7-14); D013667:Technetium; D001839:Bombesin