title: Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.
abstract: Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.
authors.affiliation: Chemical Biology Department, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nogawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Okano
authors.forename: Shunji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Uramoto
authors.forename: Hideaki
authors.initials: H
authors.lastname: Konno
authors.forename: Tamio
authors.initials: T
authors.lastname: Saito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007769:Lactams; D018942:Macrolides; C555151:verticilactam