title: Reversible escitalopram-induced hypothyroidism.
abstract: Some drugs can cause alterations in the concentration of thyroid hormones in blood even without clinical signs of dysfunction or pathology of the thyroid gland. Apart from the well-known relationship between depression and hypothalamic-pituitary-thyroid (HPT) axis, and the impact of selective serotonin reuptake inhibitors (SSRIs) on thyroid indices, hypothyroidism is a very rare adverse effect of SSRI treatment. However, the case presented here demonstrates that escitalopram may have the potential to induce hypothyroidism without any significant clinical signs and symptoms. Therefore, the possibility of SSRI-induced asymptomatic hypothyroidism presented here may help clinicians in this regard.
authors.affiliation: Department of Psychiatry, Uludag University Medical Faculty, 16059 Bursa, Turkey. saygineker@yahoo.com
authors.forename: Salih Saygin
authors.initials: SS
authors.lastname: Eker
authors.forename: Cengiz
authors.initials: C
authors.lastname: Akkaya
authors.forename: Canan
authors.initials: C
authors.lastname: Ersoy
authors.forename: Asli
authors.initials: A
authors.lastname: Sarandol
authors.forename: Selcuk
authors.initials: S
authors.lastname: Kirli
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use / Q000633:toxicity*; D015283:Citalopram / Q000627:therapeutic use / Q000633:toxicity*; D003866:Depressive Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D050031:Hashimoto Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines / Q000627:therapeutic use; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D044005:Tetrahydroisoquinolines; D015283:Citalopram; D013974:Thyroxine; D000077583:Quinapril