title: Sanosil, a more effective agent for preventing the hospital-acquired ventilator associated pneumonia.
abstract: OBJECTIVE
  The aim of this study is to compare the effects of Sanosil and glutaraldehyde 2 percent in disinfecting ventilator connecting tubes in an intensive care unit (ICU) environment.
  
  
  METHODS
  The 12-week open-labelled clinical trial was conducted in the surgical ICU of a teaching hospital from March to May 2005. In the first phase of the study, high level disinfection was performed using glutaraldehyde 2 percent, whereas Sanosil was used as the disinfectant agent of the second phase. Samples for microbial culture were obtained from the Y piece, the expiratory limb proximal to the ventilator and the humidifier in different stages; the results were then compared.
  
  
  RESULTS
  Positive culture was more frequently reported in Y pieces, humidifiers and expiratory end of ventilators. Comparing the two groups, there were more positive cultures in the glutaraldehyde group (p value = 0.005); multiple organism growths, gram negative, gram positive and fungi were also more frequent in this group (p value = 0.01; 0. 007; 0. 062; 0.144, respectively).
  
  
  CONCLUSIONS
  The paper shows that Sanosil is an effective agent in reducing the contamination risk in the tubes used in ICUs.
authors.affiliation: Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fardin
authors.initials: F
authors.lastname: Yousefshahi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khajavi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Anbarafshan
authors.forename: Patricia
authors.initials: P
authors.lastname: Khashayar
authors.forename: Atabak
authors.initials: A
authors.lastname: Najafi
mesh_terms: D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control*; D004202:Disinfectants / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D005976:Glutaral / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017053:Infection Control / Q000379:methods; D053717:Pneumonia, Ventilator-Associated / Q000382:microbiology / Q000517:prevention & control*; D012834:Silver / Q000494:pharmacology
chemical_list: D004202:Disinfectants; D012834:Silver; D006861:Hydrogen Peroxide; D005976:Glutaral