Importance of the caspase cleavage site in amyloid-β protein precursor.
Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-β protein precursor (AβPP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in AβPP.
Bredesen
Dale E
DE
Buck Institute for Age Research, Novato, CA 94945, USA. dbredesen@buckinstitute.org
John
Varghese
V
Galvan
Veronica
V
D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001284:Atrophy; D020169:Caspases / Q000737:chemistry / Q000378:metabolism*; D016923:Cell Death / Q000235:genetics; D016503:Drug Delivery Systems; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D017774:Long-Term Potentiation / Q000235:genetics; D008569:Memory Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D013569:Synapses / Q000235:genetics / Q000473:pathology
D016564:Amyloid beta-Protein Precursor; D020169:Caspases