Epigenetic networks and miRNAs in stem cells and cancer.
Stem-like cells in human cancer (CSCs) have multiple properties of embryonic stem cells (ESCs). In this issue, Iliopoulos et al. (2010) identify molecular mechanisms that link miRNAs to epigenetic states and drive CSCs, contributing to tumor aggressiveness.
Zahnow
Cynthia A
CA
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical, Institutions, Baltimore, MD 21231, USA.
Baylin
Stephen B
SB