A responsive europium(III) chelate that provides a direct readout of pH by MRI.
A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.
Wu
Yunkou
Y
Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.
Soesbe
Todd C
TC
Kiefer
Garry E
GE
Zhao
Piyu
P
Sherry
A Dean
AD
D002614:Chelating Agents / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000379:methods*
D002614:Chelating Agents; D005063:Europium