Bone matrix to growth factors: location, location, location.
The demonstration that fibrillin-1 mutations perturb transforming growth factor (TGF)-β bioavailability/signaling in Marfan syndrome (MFS) changed the view of the extracellular matrix as a passive structural support to a dynamic modulator of cell behavior. In this issue, Nistala et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003089) advance this concept by demonstrating how fibrillin-1 and -2 regulate TGF-β and bone morphogenetic protein (BMP) action during osteoblast maturation.
Rifkin
Daniel B
DB
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Daniel.Rifkin@nyumc.org
Todorovic
Vesna
V
D000818:Animals; D001857:Bone Matrix / Q000378:metabolism* / Q000473:pathology; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D000071838:Fibrillin-1; D000071837:Fibrillins; D006801:Humans; D051379:Mice; D008840:Microfilament Proteins / Q000172:deficiency / Q000378:metabolism; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D054392:Adipokines
D019485:Bone Morphogenetic Proteins; D000071838:Fibrillin-1; D000071837:Fibrillins; D008840:Microfilament Proteins; D016212:Transforming Growth Factor beta; C000605722:FBN1 protein, human; D054392:Adipokines; C000605724:Fbn1 protein, mouse