title: Calpain 10 gene and laryngeal cancer: a survival analysis.
abstract: BACKGROUND
  Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+-dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (CAPN10) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival.
  
  
  METHODS
  Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP-44, UCSNP-43, UCSNP-19, and UCSNP-63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model.
  
  
  RESULTS
  UCSNP-19, UCSNP-43, and UCSNP-44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP-63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21-6.20).
  
  
  CONCLUSIONS
  CAPN10 UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario Virgen del Rocío, Avda Manuel Siurot s/n, 41013 Sevilla, Spain. ramoluorl@gmail.com
authors.forename: Ramón
authors.initials: R
authors.lastname: Moreno-Luna
authors.forename: Antonio
authors.initials: A
authors.lastname: Abrante
authors.forename: Francisco
authors.initials: F
authors.lastname: Esteban
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: González-Moles
authors.forename: Miguel
authors.initials: M
authors.lastname: Delgado-Rodríguez
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Sáez
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Pérez
authors.forename: Reposo
authors.initials: R
authors.lastname: Ramírez-Lorca
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Real
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000368:Aged; D000483:Alleles; D000704:Analysis of Variance; D002154:Calpain / Q000235:genetics*; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D013030:Spain; D016019:Survival Analysis
chemical_list: D004273:DNA, Neoplasm; D002154:Calpain; C415197:calpain 10