Geranylated flavonols from Macaranga rhizinoides.
Two geranylated and methylated flavonol derivatives, macarhizinoidins A (1) and B (2), along with a known phenolic compound methyl 4-isoprenyloxycinnamate (3), have been isolated from the methanol extract of the leaves M. rhizinoides. The structures of these compounds were identified based on their spectroscopic data. On cytotoxic evaluation against murine leukemia P-388 cells, compounds 1-2 showed IC50 values of 11.4 and 13.9 microM, respectively, while compound 3 was inactive.
Tanjung
Mulyadi
M
Natural Products Chemistry Research Group, Organic Chemistry Division, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
Mujahidin
Didin
D
Hakim
Euis H
EH
Darmawan
Ahmad
A
Syah
Yana M
YM
D000818:Animals; D019665:Euphorbiaceae / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000032:analysis
D044948:Flavonols; D010936:Plant Extracts; C552823:macarhizinoidin A; C552824:macarhizinoidin B