title: The relation between the duty cycle and anesthetic effect in lidocaine iontophoresis using alternating current.
abstract: We assessed the effect of the duty cycle on the anesthetic effect during lidocaine alternating current (AC) iontophoresis. A solution of 2% lidocaine was delivered to the medial antecubital skin for 20 minutes using AC iontophoresis with a duty cycle of 60%, 70%, or 80%. The von Frey test was then performed to evaluate the anesthetic effect. In the groups treated with a duty cycle of 80% or 70% the touch thresholds (TT) were significantly elevated from 0 minutes to 30 minutes and from 0 minutes to 20 minutes. TT were significantly elevated at 0 minutes in the group treated with a 60% duty cycle. The anesthetic effect was significantly enhanced in a duty cycle-dependent manner.
authors.affiliation: Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. ryoanph@tmd.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Wakita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Yu
authors.initials: Y
authors.lastname: Haida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Umino
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Fukayama
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D004560:Electricity; D005260:Female; D006801:Humans; D007478:Iontophoresis / Q000379:methods*; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D013997:Time Factors; D014110:Touch / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine