Sanosil, a more effective agent for preventing the hospital-acquired ventilator associated pneumonia.
OBJECTIVE
The aim of this study is to compare the effects of Sanosil and glutaraldehyde 2 percent in disinfecting ventilator connecting tubes in an intensive care unit (ICU) environment.


METHODS
The 12-week open-labelled clinical trial was conducted in the surgical ICU of a teaching hospital from March to May 2005. In the first phase of the study, high level disinfection was performed using glutaraldehyde 2 percent, whereas Sanosil was used as the disinfectant agent of the second phase. Samples for microbial culture were obtained from the Y piece, the expiratory limb proximal to the ventilator and the humidifier in different stages; the results were then compared.


RESULTS
Positive culture was more frequently reported in Y pieces, humidifiers and expiratory end of ventilators. Comparing the two groups, there were more positive cultures in the glutaraldehyde group (p value = 0.005); multiple organism growths, gram negative, gram positive and fungi were also more frequent in this group (p value = 0.01; 0. 007; 0. 062; 0.144, respectively).


CONCLUSIONS
The paper shows that Sanosil is an effective agent in reducing the contamination risk in the tubes used in ICUs.
Yousefshahi
Fardin
F
Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Khajavi
Mohammad Reza
MR
Anbarafshan
Mohammad
M
Khashayar
Patricia
P
Najafi
Atabak
A
D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control*; D004202:Disinfectants / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D005976:Glutaral / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017053:Infection Control / Q000379:methods; D053717:Pneumonia, Ventilator-Associated / Q000382:microbiology / Q000517:prevention & control*; D012834:Silver / Q000494:pharmacology
D004202:Disinfectants; D012834:Silver; D006861:Hydrogen Peroxide; D005976:Glutaral