Comparison of the inhibitory effect of T-2 toxin on bovine platelet function with that of other known platelet inhibitors.
The inhibitory effects of T-2 toxin on bovine platelet function and thromboxane A(2) production were compared with those of the known inhibitors of human platelet function, acetylsalicylic acid, dipyridamole and verapamil. T-2 toxin (1 × 10(-3)M) effectively inhibited bovine platelet aggregation (33.2-64.3%), whereas neither acetylsalicylic acid nor dipyridamole did so. T-2 toxin appeared to be a less effective inhibitor of platelet aggregation than the calcium channel blocker, verapamil. T-2 toxin (1 × 10(-3)M) added to platelet suspensions together with verapamil, produced an additive inhibitory response. T-2 toxin (2.5 × 10(-4)M) effectively inhibited the release of thromboxane A(2) from ADP-stimulated bovine platelets as did acetylsalicylic acid and verapamil but not dipyridamole. T-2 toxin appears to inhibit bovine platelets by a biochemical mechanism distinct from that of the other inhibitors.
Bondy
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Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Gentry
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PA