A Bisindole Alkaloid with Hedgehog Signal Inhibitory Activity from the Myxomycete Perichaena chrysosperma.
6-Hydroxy-9'-methoxystaurosporinone (1), a new bisindole alkaloid, was isolated from field-collected fruiting bodies of the myxomycete Perichaena chrysosperma, together with two known compounds. The structure of the new alkaloid was elucidated from spectral data, and compound 1 was shown to have hedgehog signal inhibitory activity. A related new alkaloid, 6,9'-dihydroxystaurosporinone (4), was also isolated from Arcyria cinerea.
Shintani
Akinori
A
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Toume
Kazufumi
K
Rifai
Yusnita
Y
Arai
Midori A
MA
Ishibashi
Masami
M
D000818:Animals; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D015394:Molecular Structure; D009235:Myxomycetes / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
D026121:Indole Alkaloids