title: Spontaneously Resolving Periocular Erythema and Ciliary Madarosis Following Intra-arterial Chemotherapy for Retinoblastoma.
abstract: OBJECTIVE
  To describe an unusual clinical finding seen in children undergoing intra-arterial chemotherapy for retinoblastoma.
  
  
  METHODS
  A retrospective review of 69 eyes of 63 patients receiving intra-arterial chemotherapy over a 3-year period. Charts and photographs of 69 consecutive cases were reviewed, and data were collected on patients with clinical evidence of a hyperemic cutaneous periocular abnormality following the procedure.
  
  
  RESULTS
  A blanching erythematous and edematous patch was noted in the periocular region in 16% (11 of 69) of the children who received intraarterial chemotherapy. The plaque extended into the region of the supertrochlear and medial marginal artery distribution on the ipsilateral side of the intra-arterial chemotherapy. All patches of erythema spontaneously resolved within 3 months following completion of the intra-arterial chemotherapy.
  
  
  CONCLUSIONS
  Periocular erythema and swelling is a self-limited clinical finding associated with intra-arterial chemotherapy in a small number of patients.
authors.affiliation: Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Marr
authors.forename: Pierre Y
authors.initials: PY
authors.lastname: Gobin
authors.forename: Ira J
authors.initials: IJ
authors.lastname: Dunkel
authors.forename: Scott E
authors.initials: SE
authors.lastname: Brodie
authors.forename: David H
authors.initials: DH
authors.lastname: Abramson