title: Dietary acrylamide intake and the risk of cancer among Finnish male smokers.
abstract: OBJECTIVE
  To assess the association between dietary acrylamide intake and the risk of cancer among male smokers.
  
  
  METHODS
  The study consisted of 27,111 male smokers, aged 50-69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire and a questionnaire on general background characteristics (including smoking habits) at baseline. Incident cases of cancer were identified through the national Finnish Cancer Registry.
  
  
  RESULTS
  During an average 10.2 year follow-up, 1,703 lung cancers, 799 prostate cancers, 365 urothelial cancers, 316 colorectal cancers, 224 stomach cancers, 192 pancreatic cancers, 184 renal cell cancers, and 175 lymphomas were diagnosed. Dietary acrylamide intake was positively associated with the risk of lung cancer; relative risk (RR) in the highest versus the lowest quintile in the multivariable-adjusted model was 1.18 ((95% confidence interval (CI) 1.01-1.38, p for trend 0.11). Other cancers were not associated with acrylamide intake.
  
  
  CONCLUSIONS
  High acrylamide intake is associated with increased risk of lung cancer but not with other cancers in male smokers.
authors.affiliation: Finnish Food Safety Authority, Risk Assessment Unit, Mustialankatu 3, FI-00790 Helsinki, Finland. terohirvonen69@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Hirvonen
authors.forename: J
authors.initials: J
authors.lastname: Kontto
authors.forename: M
authors.initials: M
authors.lastname: Jestoi
authors.forename: L
authors.initials: L
authors.lastname: Valsta
authors.forename: K
authors.initials: K
authors.lastname: Peltonen
authors.forename: P
authors.initials: P
authors.lastname: Pietinen
authors.forename: S M
authors.initials: SM
authors.lastname: Virtanen
authors.forename: H
authors.initials: H
authors.lastname: Sinkko
authors.forename: C
authors.initials: C
authors.lastname: Kronberg-Kippilä
authors.forename: D
authors.initials: D
authors.lastname: Albanes
authors.forename: J
authors.initials: J
authors.lastname: Virtamo
mesh_terms: D020106:Acrylamide / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D004032:Diet / Q000009:adverse effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D010919:Placebos; D012306:Risk; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology*; D024502:alpha-Tocopherol / Q000008:administration & dosage; D019207:beta Carotene / Q000008:administration & dosage
chemical_list: D010919:Placebos; D019207:beta Carotene; D020106:Acrylamide; D024502:alpha-Tocopherol