title: Can F-MTI semantic-mined drug codes be used for adverse drug events detection when no CPOE is available?
abstract: BACKGROUND
  Adverse Drug Events (ADEs) endanger the patients. Their detection and prevention is essential to improve the patients' safety. In the absence of computerized physician order entry (CPOE), discharge summaries are the only source of information about the drugs prescribed during a hospitalization. The French Multierminology Indexer (F-MTI) can help to extract drug-related information from those records.
  
  
  METHODS
  In first and second validation steps, the performance of the F-MTI tool is evaluated to extract ICD10 and ATC codes from free-text documents. In third step, potential ADE detection rules are used and the confidences of those rules are compared in several hospitals: using a CPOE vs. using semantic mining of free-text documents, diagnoses and lab results being available in both cases.
  
  
  RESULTS
  The F-MTI tool is able to extract ATC codes from documents. Moreover, the evaluation shows coherent and comparable results between the hospitals with CPOEs and the hospital with drugs information extracted from the reports for potential ADE detection.
  
  
  CONCLUSIONS
  semantic mining using F-MTI can help to identify previous cases of potential ADEs in absence of CPOE.
authors.affiliation: Medical Information Records Department EA2694, University Hospital, Lille, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Merlin
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chazard
authors.forename: Suzanne
authors.initials: S
authors.lastname: Pereira
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Serrot
authors.forename: Saoussen
authors.initials: S
authors.lastname: Sakji
authors.forename: Régis
authors.initials: R
authors.lastname: Beuscart
authors.forename: Stefan
authors.initials: S
authors.lastname: Darmoni
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D057225:Data Mining / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D038801:International Classification of Diseases; D050316:Medical Order Entry Systems; D008508:Medication Errors / Q000517:prevention & control; D012660:Semantics; D012984:Software; D009626:Terminology as Topic