Helicobacter pylori infection: protective against increased interdialytic weight gain in asymptomatic hemodialysis patients?
OBJECTIVE
Infection with Helicobacter pylori, which induces persistent and uncontrolled gastric inflammation leading to decreased appetite, might be protective against obesity. There is a close relationship between interdialytic weight gain (IDWG) and nutritional parameters, confirming the role of IDWG as a marker of calorie and protein intake in hemodialysis (HD) patients. Hypothesis of the present study was that infection with H pylori in subjects with uremia might cause inflammation, diminished appetite, anorexia, and decreased IDWG.


METHODS
A cross-sectional study was conducted.


METHODS
This trial involved HD patients from a state hospital.


METHODS
Demographic, laboratory, and clinical parameters were collected. All patients were clinically stable and euvolemic and their average IDWG percent was calculated. Malnutrition inflammation score, spKt/V, and normalized protein equivalent of total nitrogen appearance were determined. Patients were asked to rate their appetite status from 1 to 5 on a Likert scale (very good, good, fair, poor, and very poor appetite, respectively). An H pylori infection was detected by the H pylori stool antigen (HpSA) in all the patients.


RESULTS
HpSA was positive in 18 (30%) patients. None of the demographic and laboratory parameters differed between patients infected with HpSA and the noninfected patients. Stepwise linear regression analysis of independent factors related with IDWG% revealed that daily urine output (β = -0.432, P < .0001), serum phosphorus (β = +0.343, P = .004), and hemoglobin (β = +0.358, P = .003) were related with IDWG%.


CONCLUSIONS
Infection with H pylori is not related with IDWG% and nutritional parameters in HD patients.
Afsar
Baris
B
Department of Nephrology, Zonguldak Atatürk Government Hospital, Zonguldak, Turkey. afsarbrs@yahoo.com
Elsurer
Rengin
R
Huddam
Bulent
B
Erden
Caner
C
D000328:Adult; D000368:Aged; D015415:Biomarkers; D003430:Cross-Sectional Studies; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D016014:Linear Models; D008297:Male; D044342:Malnutrition / Q000150:complications; D008875:Middle Aged; D009752:Nutritional Status; D015995:Prevalence; D006435:Renal Dialysis; D015430:Weight Gain
D015415:Biomarkers; D004044:Dietary Proteins