B-cell lymphofollicular infiltrates in mycosis fungoides.
OBJECTIVE
The histopathological picture of mycosis fungoides can be characterized by heavy reactive infiltrates. These are rarely composed of B lymphocytes with formation of reactive follicles.


METHODS
We collected three cases of mycosis fungoides with a reactive B-cell lymphofollicular reaction at the bottom of the epidermotropic infiltrate.


RESULTS
Case 1 showed flat lesions (patches) with a CD4+ neoplastic phenotype; case 2 presented infiltrated lesions (plaques) with a CD8+ immonophenotype; case 3 was characterized by nodular lesions (tumors) with a CD4+ neoplastic component. In all three cases, no clonal gene rearrangement was found with the polymerase chain reaction technique.


CONCLUSIONS
Among the protean clinicopathological features which mycosis fungoides can show, we underline that a B-cell lymphofollicular component can be encountered at the base of the epidermotropic infiltrate even in clinically flat ("patchy") lesions.
Ferrara
Gerardo
G
Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Benevento, Italy. gerardo.ferrara@libero.it
Chiarelli
Concetta
C
Simonetti
Stefano
S
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000737:chemistry / Q000473:pathology*; D012867:Skin / Q000737:chemistry / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
D015703:Antigens, CD