Instrumentation for LC-MS/MS in proteomics.
Mass spectrometers now have sufficient sensitivity and acquisition rates to allow analysis of complex proteomic samples on a chromatographic timescale. In this chapter the different instrument options for protein and peptide analysis will be presented, along with their relative strengths and weaknesses for producing different types of information, such as protein identification, modification characterization, or reporting quantitative measurements.
Chalkley
Robert
R
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, USA.
D000818:Animals; D002853:Chromatography, Liquid / Q000295:instrumentation*; D006801:Humans; D040901:Proteomics / Q000295:instrumentation*; D053719:Tandem Mass Spectrometry / Q000295:instrumentation*