title: Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate.
abstract: An efficient method for highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids was developed via indium mediated allylation of (R)-phenylglycinol methyl ether based imines of trifluoropyruvate in good yields with high diastereoselectivities at room temperature; to illustrate the application of this method in organic synthesis, 2-allyl-2-(trifluoromethyl) aziridine was prepared in an efficient manner.
authors.affiliation: State Key Laboratory of Virology, College of Pharmacy, Wuhan University, Wuhan, 430071, China.
authors.forename: Qiao-Qiao
authors.initials: QQ
authors.lastname: Min
authors.forename: Chun-Yang
authors.initials: CY
authors.lastname: He
authors.forename: Haibing
authors.initials: H
authors.lastname: Zhou
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011773:Pyruvates / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007097:Imines; D011773:Pyruvates