title: Effect of endurance exercise training on oxidative stress in spontaneously hypertensive rats (SHR) after emergence of hypertension.
abstract: The purpose of this study is to elucidate the effect of wheel training on oxidative stress maker levels in spontaneous hypertensive rats (SHR). 4-hydroxynonenal and 3-nitrotyrosine levels in the aorta of SHRs were allowed to run for 10 weeks from the age of 15 weeks were measured and compared with those of nonexercised SHRs. The 4-hydroxynonenal and 3-nitrotyrosine levels in the exercised group were significantly lower than those in the nonexercised group. The exercised group showed a significant increase of manganese-containing superoxide dismutase. Endurance exercise showed a possible suppressing effect on the arteriosclerosis development by reducing oxidative stress, even after emergence of hypertension.
authors.affiliation: Department of Forensic Medicine, Juntendo University School of Medicine, Tokyo, Japan. hkim@juntendo.ac.jp
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kimura
authors.forename: Nobuko
authors.initials: N
authors.lastname: Kon
authors.forename: Satoshi
authors.initials: S
authors.lastname: Furukawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mukaida
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Yamakura
authors.forename: Kazuko
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Kimiko
authors.initials: K
authors.lastname: Murakami-Murofushi
mesh_terms: D000367:Age Factors; D000447:Aldehydes / Q000032:analysis*; D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure; D003324:Coronary Artery Disease / Q000209:etiology / Q000517:prevention & control; D015200:Fluoroimmunoassay; D006973:Hypertension / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D009043:Motor Activity; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal; D010807:Physical Endurance; D051381:Rats; D011918:Rats, Inbred SHR; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis; D000099156:Superoxide Dismutase 2
chemical_list: D000447:Aldehydes; D009569:Nitric Oxide; D013482:Superoxide Dismutase; D013481:Superoxides; D014443:Tyrosine; D000099156:Superoxide Dismutase 2; C002744:3-nitrotyrosine; C027576:4-hydroxy-2-nonenal