title: Nanotechnology: what is it and why is small so big?
abstract: SIZE matters… the size of the scalpel determines the precision of the surgery. Nanotechnology affords us the chance to construct nanotools that are on the size scale of molecules, allowing us to treat each cell of the human body as a patient. Nanomedicine will allow for eradication of disease at the single-cell level. Since nanotools are self-assembling, nanomedicine has the potential to perform parallel processing medicine on a massive scale. These nanotools can be made of biocompatible and biodegradable nanomaterials. They can be "smart" in that they can use sophisticated targeting strategies, which can perform error checking to prevent harm if even a very small fraction of them are mistargeted. Built-in molecular biosensors can provide controlled drug delivery with feedback control for individual cell dosing. If designed to repair existing cells rather than to just destroy diseased cells, these nanomedical devices can perform in-situ regenerative medicine, programming cells along less dangerous cell pathways to prevent tissues and organs from being destroyed by the treatments and thus providing an attractive alternative to allogeneic organ transplants. Nanomedical tools, while tiny in size, can have a huge impact on medicine and health care. Earlier and more sensitive diagnosis will lead to presymptomatic diagnosis and treatment of disease before permanent damage occurs to tissues and organs. This should result in the delivery of better medicine at lower costs with better outcomes. Lastly, and importantly, some of the first uses of nanotechnology and nanomedicine are occurring in the field of ophthalmology. Some of the potential benefits of nanotechnology for future treatment of retinopathies and optic nerve damage are discussed at the end of this paper.
authors.affiliation: School of Veterinary Medicine, Purdue University, West Lafayette, Ind., USA. jfleary@purdue.edu
authors.forename: James F
authors.initials: JF
authors.lastname: Leary
mesh_terms: D005128:Eye Diseases / Q000628:therapy; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures; D036103:Nanotechnology; D009885:Ophthalmology; D018384:Oxidative Stress