Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin.
Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.
Nair
Satish K
SK
Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA.
van der Donk
Wilfred A
WA
D000613:Aminobutyrates / Q000737:chemistry / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D005578:Fosfomycin / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D063065:Organophosphonates / Q000737:chemistry / Q000378:metabolism*
D000613:Aminobutyrates; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D063065:Organophosphonates; D005578:Fosfomycin; C003121:phosphinothricin