title: Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica.
abstract: The relevance of loci associated with blood lipids recently identified in European populations in individuals of African ancestry is unknown. We tested association between lipid traits and 36 previously described single-nucleotide polymorphisms (SNPs) in 1,466 individuals of African ancestry from Spanish Town, Jamaica. For the same allele and effect direction as observed in individuals of European ancestry, SNPs at three loci (1p13, 2p21, and 19p13) showed statistically significant association (p < 0.05) with LDL, two loci (11q12 and 20q13) showed association with HDL cholesterol, and two loci (11q12 and 2p24) showed association with triglycerides. The most significant association was between a SNP at 1p13 and LDL cholesterol (p = 4.6 × 10(-8)). This SNP is in a linkage disequilibrium region containing four genes (CELSR2, PSRC1, MYBPHL, and SORT1) and was recently shown to relate to risk for myocardial infarction. Overall, the results of this study suggest that much of the genetic variation which influences blood lipids is shared across ethnic groups.
authors.affiliation: Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: R
authors.initials: R
authors.lastname: Gupta
authors.forename: K
authors.initials: K
authors.lastname: Ejebe
authors.forename: J
authors.initials: J
authors.lastname: Butler
authors.forename: G
authors.initials: G
authors.lastname: Lettre
authors.forename: H
authors.initials: H
authors.lastname: Lyon
authors.forename: C
authors.initials: C
authors.lastname: Guiducci
authors.forename: R
authors.initials: R
authors.lastname: Wilks
authors.forename: F
authors.initials: F
authors.lastname: Bennett
authors.forename: T
authors.initials: T
authors.lastname: Forrester
authors.forename: B
authors.initials: B
authors.lastname: Tayo
authors.forename: K
authors.initials: K
authors.lastname: Musunuru
authors.forename: J
authors.initials: J
authors.lastname: Hirschhorn
authors.forename: S
authors.initials: S
authors.lastname: Kathiresan
authors.forename: R S
authors.initials: RS
authors.lastname: Cooper
authors.forename: C A
authors.initials: CA
authors.lastname: McKenzie
mesh_terms: D000328:Adult; D000368:Aged; D044383:Black People / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D007563:Jamaica / Q000208:ethnology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D044465:White People / Q000235:genetics*
chemical_list: D008055:Lipids