title: Taste genes associated with dental caries.
abstract: Dental caries is influenced by a complex interplay of genetic and environmental factors, including dietary habits. Previous reports have characterized the influence of genetic variation on taste preferences and dietary habits. We therefore hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection. Families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data, and clinical assessment of oral health, including caries scores. Multiple single-nucleotide polymorphism (SNP) assays for each gene were performed and analyzed by transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups: primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.
authors.affiliation: Center for Oral Health Research in Appalachia, University of Pittsburgh, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Wendell
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: M E
authors.initials: ME
authors.lastname: Cooper
authors.forename: R S
authors.initials: RS
authors.lastname: DeSensi
authors.forename: R J
authors.initials: RJ
authors.lastname: Weyant
authors.forename: R
authors.initials: R
authors.lastname: Crout
authors.forename: D W
authors.initials: DW
authors.lastname: McNeil
authors.forename: M L
authors.initials: ML
authors.lastname: Marazita
mesh_terms: D000225:Adenine; D000328:Adult; D000409:Alanine / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003596:Cytosine; D004245:DMF Index; D003731:Dental Caries / Q000209:etiology / Q000235:genetics*; D003733:Dental Caries Susceptibility / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006147:Guanine; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011392:Proline / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D012307:Risk Factors; D013649:Taste / Q000235:genetics*; D013941:Thymine; D015293:Transducin / Q000235:genetics; D014633:Valine / Q000235:genetics; D000098706:Taste Receptors, Type 2
chemical_list: D043562:Receptors, G-Protein-Coupled; C431926:taste receptors, type 1; D000098706:Taste Receptors, Type 2; C075192:gustducin; D006147:Guanine; D003596:Cytosine; D011392:Proline; D015293:Transducin; D014633:Valine; D000225:Adenine; D000409:Alanine; D013941:Thymine