IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.
The IgE-suppressive activity of (-)-matairesinol is demonstrated, and the structure-activity relationship of (-)-matairesinol clarified. 3',4-Dihydroxy-3,4'-dimethoxylignano-9,9'-lactone showed higher IgE-suppressive activity than (-)-matairesinol without any cytotoxic activity. Some derivatives bearing a longer and more bulky alkoxy group at the 3 or 4 position showed IgE-accelerative activity.
Kawahara
Saya
S
Faculty of Agriculture, Ehime University, Ehime, Japan.
Iwata
Ipei
I
Fujita
Eriko
E
Yamawaki
Manami
M
Nishiwaki
Hisashi
H
Sugahara
Takuya
T
Yamauchi
Satoshi
S
Akiyama
Koichi
K
Kishida
Taro
T
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007073:Immunoglobulin E / Q000187:drug effects*; D007783:Lactones; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D005663:Furans; D007783:Lactones; D017705:Lignans; D007073:Immunoglobulin E; C068935:matairesinol