Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells.
Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas.
Yu
Fang
F
Brain Tumour Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China. yufang@hkusua.hku.hk
Ng
Samuel S M
SS
Chow
Billy K C
BK
Sze
Johnny
J
Lu
Gang
G
Poon
Wai Sang
WS
Kung
Hsiang-Fu
HF
Lin
Marie C M
MC
D000943:Antigens, Differentiation / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation; D055785:Gene Knockdown Techniques; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000943:Antigens, Differentiation; C062010:leu-13 antigen