title: A folding "framework structure" of Tetrahymena group I intron.
abstract: We have published the dynamic extended folding (DEF) method, which is a RNA secondary structure prediction approach-to simulate the in vivo RNA co-transcriptional folding process. In order to verify the reliability of the method, we selected the X-ray-determined Tetrahymena group I intron as a sample to construct the framework of its folding secondary structure. Our prediction coincides well with the secondary structure predicted by T.R. Cech and the X-ray diffraction crystal structure determined by Lehnert V. Our results show that the DEF framework structure of Tetrahymena group I intron reflects its function sites in a concise and straightforward manner, and the scope of the simulation was expanded.
authors.affiliation: Modern Biological Research Center, Yunnan University, Kunming 650091, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Guo
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Huai
authors.initials: H
authors.lastname: Cao
authors.forename: Huazhen
authors.initials: H
authors.lastname: Xie
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.forename: Ciquan
authors.initials: C
authors.lastname: Liu
mesh_terms: D001483:Base Sequence; D007438:Introns / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics*; D013768:Tetrahymena / Q000235:genetics*
chemical_list: D012313:RNA