The evolvability of lead peptides from small library screens.
Very little is known about the evolvability of lead peptides that are isolated from small library screens. Here we begin to explore this question by comparing the directed evolution of two peptides previously isolated from a small library screen to new ligands generated de novo by in vitro selection.
Zhang
Jinglei
J
Center for Evolutionary Medicine and Informatics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287-5301, USA.
Williams
Berea A R
BA
Nilsson
Mikael T
MT
Chaput
John C
JC
D000595:Amino Acid Sequence; D019020:Directed Molecular Evolution / Q000379:methods*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011487:Protein Conformation; D014168:Transferrin / Q000737:chemistry / Q000378:metabolism
D008024:Ligands; D019151:Peptide Library; D010455:Peptides; D014168:Transferrin