Amphotericin B--fat emulsion in treatment of visceral leishmaniasis--a cost effective substitute for liposomal amphotericin B.
In spite of high dosage and prolonged treatment schedule of sodium antimony gluconate, unresponsiveness and relapse ranging from 25 to 40% has been reported. The cure rate of 90 to 92.9% with amphotericin B-fat emulsion is comparable to that with liposomal amphotericin B (80 to 100%). Due to high cost liposomal amphotericin B is beyond the reach of most of the Indian patients, whereas the cost of treatment with amphotericin B-fat emulsion is quite affordable. Further large scale studies with amphotericin B-fat emulsion are required to evaluate its effectiveness in Indian kala-azar patients and to establish its optimal dose.
Singh
Ganesh Pd
GP
Department of Medicine, Patna Medical College and Hospital, Patna.
Saxena
R K
RK
Priyadarshy
V
V
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000191:economics; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000191:economics; D003362:Cost-Benefit Analysis; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000191:economics; D005260:Female; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
D000981:Antiprotozoal Agents; D005217:Fat Emulsions, Intravenous; D008081:Liposomes; D000666:Amphotericin B