title: Serum selenium levels in cirrhotic patients are not influenced by the disease severity index.
abstract: Selenium (Se) is an antioxidant element that protects against cellular damage by reactive oxygen species. Therefore, total serum Se concentration may reflect protection during the development of cirrhosis, an oxidative stress-related disease. We hypothesized that serum Se levels are diminished in cirrhotic patients due to their enhanced oxidative stress, and serum Se levels are reduced the most in patients with the highest severity of cirrhosis. A case-control study was performed to determine whether cirrhosis is associated with changes in serum Se levels. Blood samples from 30 healthy controls and 93 cirrhotic patients were analyzed for total serum Se by hydride generation atomic absorption spectrometry. The Child-Pugh index score was used to evaluate the severity of liver disease. The mean serum Se concentration was significantly lower in patients vs controls (0.721 ± 0.239 vs 0.926 ± 0.241 μmol/L; P = .001). Mean serum Se levels were not significantly lower in patients with higher severity of cirrhosis (0.691 ± 0.229 vs 0.755 ± 0.255 μmol/L; P = .144). A positive and significant correlation was found between age and serum Se levels in patients (r = 0.277, P = .007). Patients showed significant sex differences in serum Se level (higher in male) and severity index (higher in female). The significantly decreased serum Se level in patients indicates that the Se component of the antioxidant system is severely impaired in cirrhosis. However, serum Se levels were not influenced by the severity of the disease.
authors.affiliation: Department of Nutrition and Food Science, School of Pharmacy, University of Granada, E-18071 Granada, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Martínez-Peinado
authors.forename: Flor
authors.initials: F
authors.lastname: Nogueras-López
authors.forename: Antonio
authors.initials: A
authors.lastname: Arcos-Cebrián
authors.forename: Ahmad
authors.initials: A
authors.lastname: Agil
authors.forename: Miguel
authors.initials: M
authors.lastname: Navarro-Alarcón
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012643:Selenium / Q000097:blood*; D012720:Severity of Illness Index; D012737:Sex Factors; D013054:Spectrophotometry, Atomic
chemical_list: D000975:Antioxidants; D012643:Selenium