Highly efficient synthesis of 3-amino-/alkylthio-cyclobut-2-en-1-ones based on the cyclization of acyl ketene dithioacetals.
A new strategy for the highly efficient one-pot synthesis of 3-amino-/alkylthio-cyclobut-2-en-1-ones based on the cyclization of acyl ketene dithioacetals is disclosed. In addition, the rearrangement of 3-amino-cyclobut-2-en-1-ones to 4-quinolone derivatives is described.
Zhao
Yu-Long
YL
Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhaoyl351@nenu.edu.cn
Yang
Shao-Chun
SC
Di
Chong-Hui
CH
Han
Xiao-Dan
XD
Liu
Qun
Q
D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D000080:Acetals / Q000138:chemical synthesis / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D042462:4-Quinolones; D000080:Acetals; D000588:Amines; D003503:Cyclobutanes; D013438:Sulfhydryl Compounds; C553737:cyclobutenone