Specialized chromatin patterns in the control of inflammatory gene expression.
Inflammatory responses to microbial and non-microbial stimuli involve coordinate changes in the expression of hundreds of genes. The inflammatory gene expression programs display two important features: first, alternative stimuli affect both a large set of common genes and a variable number of stimulus-specific genes. Second, different genes are activated with different kinetics over several hours after the initial stimulus. Mechanistically, these features reflect the interplay between two main groups of determinants: the combinatorial control of transcription by multiple transcription factors, with NF-κB and the IRFs playing a central and essential role in the induction of a large fraction of inflammatory genes; and the presence of well-defined, in part cell-type specific, patterns of chromatin organization at cis-regulatory regions of inflammatory genes. Recent advancements in this field are providing paradigms of general value explaining how inducible responses to environmental stimuli are controlled.
Natoli
Gioacchino
G
Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy. gioacchino.natoli@ifom-ieo-campus.it
D000818:Animals; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D016328:NF-kappa B / Q000502:physiology*; D009707:Nucleosomes / Q000502:physiology
D002843:Chromatin; D016328:NF-kappa B; D009707:Nucleosomes