Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.
Genetic variation in immune response is probably involved in the progression of sepsis and mortality in septic patients. However, findings in the literature are sometimes conflicting or their significance is uncertain. Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin α--LTA) genes and sepsis. Critically ill patients classified with sepsis, severe sepsis and septic shock and 207 healthy volunteers were analyzed and genotyped. Seven of the nine polymorphisms showed similar distributions in allele frequencies between patients and controls. Interestingly, our data suggest that the IL10-819 and TLR-2 polymorphisms may be potential predictors of sepsis.
Carregaro
Fernanda
F
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Carta
Adriana
A
Cordeiro
José Antônio
JA
Lobo
Suzana M
SM
Silva
Eloiza H Tajara da
EH
Leopoldino
Andréia M
AM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018805:Sepsis / Q000235:genetics* / Q000401:mortality; D012720:Severity of Illness Index; D051193:Toll-Like Receptors / Q000235:genetics*; D055815:Young Adult
D016207:Cytokines; D051193:Toll-Like Receptors