Epithelial sensing of fungal invasion.
The mechanisms discriminating mucosal colonization from invasion by Candida albicans are unclear. In this issue, Moyes et al. show that epithelial cells discriminate between colonizing yeasts and invading hyphae by mechanisms involving c-Fos and MKP1 phosphatase, opening up new avenues for understanding the pathophysiology of mucosal fungal infections.
Netea
Mihai G
MG
Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), Nijmegen, The Netherlands.
Kullberg
Bart Jan
BJ