title: Blood glucose dysregulation and cognitive outcome in ARDS survivors.
abstract: OBJECTIVE
  Hyperglycaemia is common in critically ill patients and may contribute to increased mortality and morbidity. This study assessed the impact of blood glucose on cognitive outcome in acute respiratory distress syndrome (ARDS) patients' 1 year post-hospital discharge.
  
  
  METHODS
  Retrospective data for 74 ARDS survivors who were enrolled in a prospective mechanical ventilation randomized clinical trial. A standard protocol was used to manage blood glucose. The highest, lowest, mean and standard deviation glucose values were examined, as well as duration of hypoxemia and other clinical data. Standardized neuropsychological tests were administered to identify cognitive sequelae. Logistic regression models were used to assess risk factors for cognitive sequelae.
  
  
  RESULTS
  There was a significant relationship between the blood glucose and cognitive sequelae. Greater duration of mechanical ventilation and highest blood glucose predicted cognitive sequelae.
  
  
  CONCLUSIONS
  Blood glucose dysregulation, specifically moderate hyperglycaemia and ICU length of stay, predicted adverse cognitive sequelae in ARDS patients.
authors.affiliation: Department of Medicine, Pulmonary and Critical Care Division, LDS Hospital, Salt Lake City, Utah, USA. ramona.hopkins@imail.org
authors.forename: Ramona O
authors.initials: RO
authors.lastname: Hopkins
authors.forename: Mary R
authors.initials: MR
authors.lastname: Suchyta
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Snow
authors.forename: Al
authors.initials: A
authors.lastname: Jephson
authors.forename: Lindell K
authors.initials: LK
authors.lastname: Weaver
authors.forename: James F
authors.initials: JF
authors.lastname: Orme
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001786:Blood Glucose / Q000502:physiology; D003072:Cognition Disorders / Q000097:blood / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000503:physiopathology* / Q000523:psychology; D002534:Hypoxia, Brain / Q000097:blood / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D016032:Randomized Controlled Trials as Topic; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000503:physiopathology* / Q000523:psychology; D012189:Retrospective Studies; D017741:Survivors; D055815:Young Adult
chemical_list: D001786:Blood Glucose