title: Iatrogenic Creutzfeldt-Jakob disease in Australia: time to amend infection control measures for pituitary hormone recipients?
abstract: From 1967, the Australian Human Pituitary Hormone Program offered treatment for short stature and infertility using human cadaver-acquired pituitary hormones (human growth hormone [hGH] and human pituitary gonadotrophin [hPG]). The program was suspended in 1985 when a growth-hormone recipient in the United States developed Creutzfeldt-Jakob disease (CJD), an incurable and rapidly progressive neurodegenerative disorder. Since this time, recipients have lived with the significant anxiety that they have an elevated risk of developing CJD. Furthermore, additional CJD infection control measures are required when recipients undergo some types of surgery. As it is 20 years since the last Australian pituitary hormone recipient developed CJD, we evaluated the risk for Australian recipients of developing iatrogenic CJD, and compared Australian data with data from New Zealand and selected other countries who had pituitary hormone programs. Our evaluation indicates that pituitary hormone recipients in Australia have the lowest risk of developing iatrogenic CJD, and that Australia is the only country not to have experienced ongoing CJD-related deaths. Thus, we believe that: in the Australian hGH recipient cohort, the risk of developing CJD is sufficiently low for this cohort to no longer require additional infection control measures in the health care setting; and in the Australian hPG recipient cohort, if another 5 years elapses with no further occurrence of CJD in this group, the hPG recipient cohort could also be considered as not requiring additional infection control measures in the health care setting. These recommendations should not be misunderstood as implying that there is no ongoing risk, but that the risk is acceptably low and generally in keeping with guidelines that stratify the risk.
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia. aboyd@unimelb.edu.au
authors.forename: Alison
authors.initials: A
authors.lastname: Boyd
authors.forename: Genevieve M J A
authors.initials: GM
authors.lastname: Klug
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Schonberger
authors.forename: Amelia
authors.initials: A
authors.lastname: McGlade
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Brandel
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Collins
mesh_terms: D001315:Australia; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D019382:Human Growth Hormone / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D017053:Infection Control; D010903:Pituitary Gland, Anterior / Q000737:chemistry; D018570:Risk Assessment; D014020:Tissue Extracts / Q000009:adverse effects
chemical_list: D014020:Tissue Extracts; D019382:Human Growth Hormone