title: Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1.
abstract: A 22-year-old man diagnosed with neurofibromatosis-I was admitted to the neurology department because of progressive hemianopsia and chronic headache. Magnetic resonance imaging, magnetic resonance spectroscopy (MRS), and F-18 fluorocholine revealed a splenial mass with imaging features compatible with malignant astrocytoma. At follow-up examination, the sharp decrease in F-18 fluorocholine uptake and in choline/creatine ratio supported a conservative management. Molecular imaging of optic pathway gliomas may be a valuable tool in the selection of therapeutic options.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Roselli
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Pisciotta
authors.forename: Maria S
authors.initials: MS
authors.lastname: Aniello
authors.forename: Artor
authors.initials: A
authors.lastname: Niccoli-Asabella
authors.forename: Giovanni
authors.initials: G
authors.lastname: Defazio
authors.forename: Paolo
authors.initials: P
authors.lastname: Livrea
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rubini
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D002794:Choline / Q000031:analogs & derivatives*; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009900:Optic Nerve; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: C514960:fluorocholine; D002794:Choline