Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model.
BACKGROUND
The use of staplers in gastrointestinal surgery is widespread, especially in advanced laparoscopic procedures. Staple line reinforcement with a buttress reduces bleeding and associated complications through a combination of factors. The intrinsic hemostatic properties of buttress materials have not been examined. This study examined the intrinsic hemostatic properties of two different types of material used in buttressing in an accepted hemostasis model that does not involve stapling or its effects by compression.


METHODS
An acellular collagen buttress (Veritas) and a synthetic polymer buttress (Duet) were compared to two commonly used hemostatic agents, Syvek and Surgicel, with gauze as control.


METHODS
In a swine capsular stripping hemostasis model, a 1 × 1 cm section of spleen capsule was removed and used as a source of bleeding, with one patch of material tested per bleeding site. A total of 51 wounds were created in five pigs (each patch n = 10, control n = 11). Hemostatic efficacy was assessed by quantitating the number of applications and total time needed for bleeding to stop.


RESULTS
The mean time needed for hemostasis for Syvek and Veritas patches was significantly less than gauze, Duet and Surgicel (4.02, 4.51 vs. 8.97, 9.22, and 10.30 min respectively; p < 0.05). The Syvek and Veritas patches required significantly fewer applications than gauze, Duet™ and Surgicel (1.7, 2.2 vs. 4.1, 4.6, and 4.9 respectively; p < 0.01).


CONCLUSIONS
The intrinsic hemostatic properties of different buttressing materials vary widely. In this study, a collagen buttress was significantly better at promoting hemostasis than the synthetic buttress material in a nonstapling model. This could be another factor to consider when choosing a buttress for staple line reinforcement.
Spector
David
D
Department of Surgery, Tufts Medical Center, 800 Washington St, Box # 437, Boston, MA 02111, USA. dspector@tuftsmedicalcenter.org
Perry
Zvi
Z
Konobeck
Tracy
T
Mooradian
Daniel
D
Shikora
Scott
S
D000117:Acetylglucosamine / Q000627:therapeutic use; D000818:Animals; D001672:Biocompatible Materials; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002483:Cellulose, Oxidized / Q000627:therapeutic use; D003094:Collagen / Q000737:chemistry / Q000627:therapeutic use*; D004146:Dioxanes / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000601:surgery*; D006488:Hemostasis, Surgical / Q000295:instrumentation / Q000379:methods*; D006490:Hemostatics / Q000627:therapeutic use*; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D013158:Splenic Diseases / Q000601:surgery*; D015503:Surgical Sponges; D017792:Surgical Stapling; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D034421:Sus scrofa; D013552:Swine; D013718:Tensile Strength
D001672:Biocompatible Materials; C106136:Biosyn terpolymer; D002483:Cellulose, Oxidized; D004146:Dioxanes; D006490:Hemostatics; D011108:Polymers; C113831:poly-N-acetyl glucosamine; C013695:Surgicel; D003094:Collagen; D000117:Acetylglucosamine