Innate immunity and vaccine.
Immune adjuvant is an artificial pathogen-associated molecular patterns (PAMP) for potentiating various immune responses. Vaccine represents one event that is capable of inducing immune response caused by antigen and PAMP stimuli, which act on antigen-presenting dendritic cells (mDCs). Here, we introduce the pathways by which CTL and NK cells are driven through mDC maturation in response to adjuvants.
Seya
Tsukasa
T
Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo 060-8638, Japan. seya-tu@pop.med.hokudai.ac.jp
D033942:Adaptor Proteins, Vesicular Transport / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D053594:Myeloid Differentiation Factor 88 / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*
D033942:Adaptor Proteins, Vesicular Transport; D000276:Adjuvants, Immunologic; D053594:Myeloid Differentiation Factor 88; D014612:Vaccines; C476286:Ticam1 protein, mouse