Calpain 10 gene and laryngeal cancer: a survival analysis.
BACKGROUND
Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+-dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (CAPN10) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival.


METHODS
Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP-44, UCSNP-43, UCSNP-19, and UCSNP-63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model.


RESULTS
UCSNP-19, UCSNP-43, and UCSNP-44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP-63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21-6.20).


CONCLUSIONS
CAPN10 UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer.
Moreno-Luna
Ramón
R
Servicio de Otorrinolaringología, Hospital Universitario Virgen del Rocío, Avda Manuel Siurot s/n, 41013 Sevilla, Spain. ramoluorl@gmail.com
Abrante
Antonio
A
Esteban
Francisco
F
González-Moles
Miguel Angel
MA
Delgado-Rodríguez
Miguel
M
Sáez
María Eugenia
ME
González-Pérez
Antonio
A
Ramírez-Lorca
Reposo
R
Real
Luis Miguel
LM
Ruiz
Agustín
A
D000368:Aged; D000483:Alleles; D000704:Analysis of Variance; D002154:Calpain / Q000235:genetics*; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D013030:Spain; D016019:Survival Analysis
D004273:DNA, Neoplasm; D002154:Calpain; C415197:calpain 10