[Indoor air guide values for benzyl alcohol].
The German Working Group on Indoor Air Guidelines of the Federal Environment Agency and the States' Health Authorities is issuing indoor air guide values to protect public health. For health evaluation of benzyl alcohol in indoor air valid inhalation studies are missing. Following subchronic oral exposure to 800 mg benzyl alcohol/kg body weight and day neurotoxicity was observed in rats. Accounting for data gaps by a factor of 2 and extrapolating to continuous exposure by applying a factor of 2 the lowest adverse effect level for chronic exposure (LAELchron) is assessed as 200 mg benzyl alcohol/kg b. w. and day. By applying an interspecies factor of 10, an intraspecies factor of 10, a path-to-path-extrapolation and a modifying factor of 2 referring to the special physiology of children (higher breathing rate compared to adults) a health hazard guide value (RW II) of 4 mg benzyl alcohol/m3 indoor air and a health precaution guide value (RW I) of 0.4 mg benzyl alcohol/m3 are derived.
D000279:Administration, Cutaneous; D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity; D016902:Air Pollution, Indoor / Q000032:analysis*; D000818:Animals; D019905:Benzyl Alcohol / Q000032:analysis* / Q000633:toxicity; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D005858:Germany; D017408:Guidelines as Topic; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced; D011247:Pregnancy; D011634:Public Health; D013045:Species Specificity; D020711:Threshold Limit Values; D055815:Young Adult
D000395:Air Pollutants, Occupational; D019905:Benzyl Alcohol