title: Latex use as an occlusive membrane for guided bone regeneration.
abstract: Latex extracted from Hevea brasiliensis was used as an occlusive membrane for guided bone regeneration. Twenty-four rabbits were divided in two groups: treated and control group. Critical size bone defects (2 cm × 1 cm) were surgically made in the rabbit calvarium. Two latex membranes were implanted in each animal of the treated group, whereas the control defect was filled only with autogenous blood clot. After 15, 30, 60, and 120 days, animals from each group were euthanized, and the samples with regenerated bone were removed. No signs of allergy or rejection were noticed around the calvarial bone defect of the treated group. In the histological analysis, no foreign body inflammatory reaction was observed in the adjacent tissues in contact with the membranes demonstrating that latex can be used at injured sites as an aid in the healing process. Histological analysis, digital radiography, and electron spin resonance were used to evaluate the progress of bone repair. The results show significant differences between groups (p < 0.05) suggesting that latex membranes accelerates healing in critical bone defects.
authors.affiliation: Programa de Pós Graduação em Biologia Oral, Universidade do Sagrado Coração, PRPPG, Bauru, São Paulo, Brazil.
authors.forename: Cibele
authors.initials: C
authors.lastname: Ereno
authors.forename: Sérgio A Catanzaro
authors.initials: SA
authors.lastname: Guimarães
authors.forename: Silvana
authors.initials: S
authors.lastname: Pasetto
authors.forename: Rondinelli Donizetti
authors.initials: RD
authors.lastname: Herculano
authors.forename: Cecília Pereira
authors.initials: CP
authors.lastname: Silva
authors.forename: Carlos F O
authors.initials: CF
authors.lastname: Graeff
authors.forename: Orivaldo
authors.initials: O
authors.lastname: Tavano
authors.forename: Oswaldo
authors.initials: O
authors.lastname: Baffa
authors.forename: Angela
authors.initials: A
authors.lastname: Kinoshita
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D002113:Calcification, Physiologic; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods; D007840:Latex; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D012886:Skull / Q000473:pathology / Q000601:surgery; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D007840:Latex