title: LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction.
abstract: A realistic goal for cardiac cell therapy may be to attenuate left ventricular remodeling following acute myocardial infarction to prevent the development of congestive heart failure. Initial clinical trials of cell therapy have delivered cells 1 to 7 days after acute myocardial infarction. However, many patients at risk of developing congestive heart failure may not be ready for cell delivery at that time-point because of clinical instability or hospitalization at facilities without access to cell therapy. Experience with cell delivery 2 to 3 weeks after acute myocardial infarction has not to date been explored in a clinical trial. The objective of the LateTIME study is to evaluate by cardiac magnetic resonance the effect on global and regional left ventricular function, between baseline and 6 months, of a single intracoronary infusion of 150 × 106 autologous bone marrow mononuclear cells (compared with placebo) when that infusion is administered 2 to 3 weeks after moderate-to-large acute myocardial infarction. The 5 clinical sites of the Cardiovascular Cell Therapy Research Network (CCTRN) will enroll a total of 87 eligible patients in a 2:1 bone marrow mononuclear cells-to-placebo patient ratio; these 87 will have undergone successful percutaneous coronary intervention of a major coronary artery and have left ventricular ejection fractions ≤0.45 by echocardiography. When the results become available, this study should provide insight into the clinical feasibility and appropriate timing of autologous cell therapy in high-risk patients after acute myocardial infarction and percutaneous coronary intervention.
authors.affiliation: Minneapolis Heart Institute at Abbott Northwestern Hospital, USA.
authors.forename: Jay H
authors.initials: JH
authors.lastname: Traverse
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Henry
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Vaughan
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ellis
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Pepine
authors.forename: James T
authors.initials: JT
authors.lastname: Willerson
authors.forename: David X M
authors.initials: DX
authors.lastname: Zhao
authors.forename: Lara M
authors.initials: LM
authors.lastname: Simpson
authors.forename: Marc S
authors.initials: MS
authors.lastname: Penn
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Byrne
authors.forename: Emerson C
authors.initials: EC
authors.lastname: Perin
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Gee
authors.forename: Antonis K
authors.initials: AK
authors.lastname: Hatzopoulos
authors.forename: David H
authors.initials: DH
authors.lastname: McKenna
authors.forename: John R
authors.initials: JR
authors.lastname: Forder
authors.forename: Doris A
authors.initials: DA
authors.lastname: Taylor
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Cogle
authors.forename: Sarah
authors.initials: S
authors.lastname: Baraniuk
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Olson
authors.forename: Beth C
authors.initials: BC
authors.lastname: Jorgenson
authors.forename: Shelly L
authors.initials: SL
authors.lastname: Sayre
authors.forename: Rachel W
authors.initials: RW
authors.lastname: Vojvodic
authors.forename: David J
authors.initials: DJ
authors.lastname: Gordon
authors.forename: Sonia I
authors.initials: SI
authors.lastname: Skarlatos
authors.forename: Lemuel A
authors.initials: LA
authors.lastname: Moyè
authors.forename: Robert D
authors.initials: RD
authors.lastname: Simari
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D004311:Double-Blind Method; D004452:Echocardiography; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D010865:Pilot Projects; D015990:Placebo Effect; D012107:Research Design; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014481:United States; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling