title: [Coronary artery dissection in young adults].
abstract: Two young patients, a 23-year-old man and a 30-year-old woman, without any risk factors for coronary artery disease, apart from the woman being a smoker, were admitted to our hospital because of acute myocardial infarction (MI) due to spontaneous dissection of a coronary artery (SDCA). The first patient developed acute chest pain while playing soccer. The second patient had unspecific chest pain in the preceding four weeks and was admitted after successful resuscitation with ventricular fibrillation. Both patients were treated with primary percutaneous coronary intervention. SDCA is a rare cause of MI and sudden cardiac death with an indistinguishable presentation due to plaque rupture. The majority of cases occur in young women. It is associated with various pathophysiological mechanisms and can manifest during pregnancy, in the postpartum period, in collagen diseases, cocaine abuse, severe hypertension, smoking, oral contraceptives, heavy exercise, or vasospasm. Treatment, pharmacological or with revascularization, is based on the severity of the dissection. Patients who survive the acute phase have good long-term prognoses.
authors.affiliation: Isala Klinieken, Zwolle, afd. Cardiologie, the Netherlands.
authors.forename: Saman
authors.initials: S
authors.lastname: Rasoul
authors.forename: Jan Paul
authors.initials: JP
authors.lastname: Ottervanger
authors.forename: Angela H E M
authors.initials: AH
authors.lastname: Maas
authors.forename: Jan C A
authors.initials: JC
authors.lastname: Hoorntje
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D002637:Chest Pain; D003323:Coronary Aneurysm / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology*; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult