Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
OBJECTIVE
To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals.


METHODS
Prospective case-control series.


METHODS
Academic referral center.


METHODS
Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant MOG (rMOG) antibody determination.


METHODS
Serum and CSF rMOG antibody and albumin levels were used to calculate an rMOG index. Clinical disability, CSF markers, and magnetic resonance metrics were correlated with the rMOG index.


RESULTS
The rMOG index was elevated in MS patients compared with controls (P = .01). Patients with progressive MS exhibited elevated rMOG indexes compared with patients with relapsing-remitting MS (P = .04). The rMOG index was inferior to the IgG index in differentiating MS patients from controls. However, 7 of 16 patients with MS who had normal immunoglobulin G indexes had an elevated rMOG index. The rMOG index did not correlate with clinical disability, other CSF markers, or radiographic outcome measures.


CONCLUSIONS
The rMOG index, a marker of intrathecal MOG antibody production, may provide complementary information to routine CSF testing in the diagnosis of MS. Furthermore, intrathecal anti-MOG antibody production may be more pronounced in progressive than in relapsing forms of MS.
Klawiter
Eric C
EC
Department of Neurology, Washington University, St Louis, MO 63110, USA.
Piccio
Laura
L
Lyons
Jeri-Anne
JA
Mikesell
Robert
R
O'Connor
Kevin C
KC
Cross
Anne H
AH
D000328:Adult; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D011446:Prospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein