Genome scan for locus involved in mandibular prognathism in pedigrees from China.
BACKGROUND
It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped.


METHODS
In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM). Multipoint parametric and non-parametric (model-free) linkage analyses were used for the pedigrees.


RESULTS
The most statistically significant linkage results were with markers on chromosome 4 (LOD=3.166 and NPL=3.65 with rs 875864, 4p16.1, 8.38 cM). Candidate genes within the 4p16.1 include EVC, EVC2.


CONCLUSIONS
We detected a novel suggestive linkage locus for mandibular prognathism in two Chinese pedigrees, and this linkage region provides target for susceptibility gene identification, a process that will provide important insights into the molecular and cellular basis of mandibular prognathism.
Li
Qin
Q
Department of Orthodontics, Dental School, Tongji University, Shanghai, China.
Zhang
Feng
F
Li
Xin
X
Chen
Fengshan
F
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002648:Child; D002681:China; D002874:Chromosome Mapping; D004198:Disease Susceptibility; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011378:Prognathism / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult