Understanding the role of tumor stem cells in glioblastoma multiforme: a review article.
It has been hypothesized that cancer stem cells (CSC) may account for the pathogenesis underlying various tumors, including GBM. Markers of these CSCs can be potentially used as therapeutic targets. In this review, we discuss the most recent information regarding CSCs, their molecular biology and their potential role in GBM.
Fatoo
Aalya
A
Neurosurgical Laboratory for Translational Stem Cell Research, Department of Neurosurgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College of Cornell University, 510 E 70th Street, New York, NY 10021, USA.
Nanaszko
Michael J
MJ
Allen
Baxter B
BB
Mok
Christina L
CL
Bukanova
Elena N
EN
Beyene
Robel
R
Moliterno
Jennifer A
JA
Boockvar
John A
JA
D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006801:Humans; D014411:Neoplastic Stem Cells / Q000502:physiology*; D015398:Signal Transduction