Strong association between a new marker of hemolysis and glomerulopathy in sickle cell anemia.
To perform a precise evaluation of the hemolytic status of patients with sickle cell anemia (SCA), advanced red blood cell parameters provided by the last generation analyzers were investigated in a series of SCA patients. The search for precise markers of hemolysis was performed to identify if patients so exposed develop organic complications related to a postulated hemolysis-linked endothelial dysfunction. Red blood cell survival was evaluated by the ratio between mature red blood cell (RBC) and reticulocyte (RET) hemoglobin (RBC-Hb/RET-Hb). In comparison with serum lactate dehydrogenase (LDH) and total bilirubin, the log (RBC-Hb/RET-Hb) was identified as the most discriminant hematological parameter to evaluate hemolysis. Furthermore, by combining this parameter with LDH, we defined a composite variable, which we called CVar, that is highly correlated with albuminuria and might constitute a powerful new marker of risk for this complication.
Maier-Redelsperger
Micheline
M
Service d'Hématologie Biologique, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, F-75020, Paris, France. micheline.maier@tnn.aphp.fr
Lévy
Pierre
P
Lionnet
François
F
Stankovic
Katia
K
Haymann
Jean-Philippe
JP
Lefèvre
Guillaume
G
Avellino
Virginie
V
Perol
Jean-Pierre
JP
Girot
Robert
R
Elion
Jacques
J
D000419:Albuminuria / Q000175:diagnosis*; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications*; D015415:Biomarkers; D002470:Cell Survival; D004912:Erythrocytes / Q000473:pathology; D005921:Glomerulonephritis / Q000175:diagnosis*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D012156:Reticulocytes / Q000473:pathology
D015415:Biomarkers; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase