title: c-Met expression is associated with time to recurrence in patients with glioblastoma multiforme.
abstract: The aim of this study was to explore the difference in c-Met expression between primary and recurrent glioblastoma multiforme (GBM), and to determine whether the dysregulation of c-Met expression has a role in the malignant progression of GBM. Paired primary and recurrent GBM specimens from the same patient were evaluated using immunohistochemical analysis. The association between c-Met expression and progression-free survival time (PFST) was analyzed. There was a significant difference in c-Met expression between primary and recurrent tumors (p=0.020), and patients with tumors expressing c-Met at a higher level had a significantly shorter PFST (6.1 months vs. 11.5 months; p=0.026). Our study indicates that recurrent GBM express c-Met at a higher level and that c-Met overexpression is associated with shorter PFST in patients with GBM. These findings suggest that c-Met potentially has an important role in the treatment of GBM.
authors.affiliation: Department of Neurosurgery, Provincial Hospital affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, Shandong 250021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yibing
authors.initials: Y
authors.lastname: Fu
authors.forename: Shangchen
authors.initials: S
authors.lastname: Xu
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhao
authors.forename: Kang
authors.initials: K
authors.lastname: Zhang
authors.forename: Chigang
authors.initials: C
authors.lastname: Du
authors.forename: Bo
authors.initials: B
authors.lastname: Pang
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*
chemical_list: D019859:Proto-Oncogene Proteins c-met