Cellular sources and immune functions of interleukin-9.
Interleukin-9 (IL-9) has attracted renewed interest owing to the identification of its expression by multiple T helper (T(H)) cell subsets, including T(H)2 cells, T(H)9 cells, T(H)17 cells and regulatory T (T(Reg)) cells. Here, we provide a broad overview of the conditions that are required for cells to produce IL-9 and describe the cellular targets and nature of the immune responses that are induced by IL-9.
Noelle
Randolph J
RJ
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. rjn@dartmouth.edu
Nowak
Elizabeth C
EC
D000818:Animals; D006801:Humans; D016906:Interleukin-9 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D016906:Interleukin-9