[Coagulation management in trauma-related massive bleeding. - Recommendations of the Task Force for Coagulation (AGPG) of the Austrian Society of Anesthesiology, Resuscitation and Intensive Care Medicine (OGARI)].
Even nowadays and at specialized centers, one of the leading causes of death is exsanguination. Trauma-induced coagulopathy (TIC) occuring with massive blood loss primarily results from loss of coagualtion factors and platelets and is aggravated by hemodilution. In addition, hyperfibrinolysis, hypothermia, acidosis and hypocalcaemia also contribute to the development of severe haemostatic derangement. During the past few years new insights into the pathophysiology of TIC and the widespread use of viscoelastic coagulation monitoring provoked the development of alternative treatment concepts. As for the previously recommended standard therapy using fresh frozen plasma and platelet concentrates also for alternative strategies no data from large prospective randomized studies are available until now, however, the evidence is growing favoring the use of coagulation factor concentrates guided by viscoelastic measurements.
Fries
Dietmar
D
Klinische Abteilung für Allgemeine und Chirurgische Intensivmedizin, Medizinische Universität Innsbruck, Osterreich.
Innerhofer
Petra
P
Perger
Peter
P
Gütl
Manfred
M
Heil
Sabine
S
Hofmann
Nikolaus
N
Kneifel
Werner
W
Neuner
Ludwig
L
Pernerstorfer
Thomas
T
Pfanner
Georg
G
Schöchl
Herbert
H
Ziegler
Bernhard
B
Kölblinger
Camillo
C
Kozek-Langenecker
Sibylle
S
D000925:Anticoagulants / Q000627:therapeutic use*; D001317:Austria; D003422:Critical Care / Q000592:standards*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D017410:Practice Guidelines as Topic; D012151:Resuscitation / Q000592:standards; D014947:Wounds and Injuries / Q000150:complications* / Q000188:drug therapy*
D000925:Anticoagulants