Dolabellane Diterpenoids from the South Atlantic Gorgonian Convexella magelhaenica.
Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations.
Rojo de Almeida
María Tereza
MT
UMYMFOR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2 (1428), Buenos Aires, Argentina.
Siless
Gastón E
GE
Perez
Carlos D
CD
Veloso
María José
MJ
Schejter
Laura
L
Puricelli
Lydia
L
Palermo
Jorge A
JA
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001267:Atlantic Ocean; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms / Q000188:drug therapy
C000606177:(1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one; C000606020:(1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one; D004224:Diterpenes; C115566:dolabellane