Aberrant expression of the pluripotency marker SOX-2 in endometriosis.
Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometriotic tissue of 36 patients. Aberrant expression of SOX-2 may indicate a stem cell origin of endometriosis, whereas the presence of all progenitor markers in endometrial tissue marks the endometrium as a potential source for induced pluripotent stem cell generation.
Götte
Martin
M
Department of Gynecology and Obstetrics, University of Münster, Medical Center, Münster, Germany. martingotte@uni-muenster.de
Wolf
Maria
M
Staebler
Annette
A
Buchweitz
Olaf
O
Kiesel
Ludwig
L
Schüring
Andreas N
AN
D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D004715:Endometriosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004717:Endometrium / Q000473:pathology / Q000502:physiology*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics; D008875:Middle Aged; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055748:SOXB1 Transcription Factors / Q000235:genetics* / Q000378:metabolism; D055153:Stem Cell Niche / Q000473:pathology / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology
D015415:Biomarkers; D018398:Homeodomain Proteins; C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; C486780:NANOG protein, human; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors