pRb, a switch between bone and brown fat.
Calo et al. (2010) recently reported that the absence of the transcriptional regulator pRb enhances differentiation of mesenchymal precursors toward the brown adipocyte lineage in detriment of osteoblast and white fat populations. These findings may have therapeutic implications for cancer and bone and metabolic disease.
Fernandez-Marcos
Pablo J
PJ
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH1015 Lausanne, Switzerland.
Auwerx
Johan
J