[Consecutive five-year follow-up analysis of specific IgG antibody of 22 cases of SARS patients after recovery].
To study IgG antibody persistence and temporal change in SARS coronavirus (SARS-CoV) infected patients, 22 patients recovered from SARS in Beijing were recruited and followed-up from 2004 to 2008, serum samples from patients were collected every year. We checked and analyzed the SARS-CoV IgG antibody (Ab) for five consecutive years using the commercial ELISA test kit. The results showed that: all of the serum were SARS-IgG antibody-positive the first year after recovery, the titer of most serum remained at high levels at the 2ed and 3rd year post infection. The Ab titers significantly declined at 4th year post infection. The IgG Ab was almost undetectable after 5 years post infection. In conclusion, SARS-CoV IgG Ab can be maintained for more than 3 years post infection, however, the titer of IgG Ab has declined markedly 4 years later. These data provide a useful reference for diagnosis and control of SARS infection, the evaluation of immune response and vaccine efficacy.
Wang
Hui-Juan
HJ
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Zhang
Ling-Lin
LL
Tan
Wen-Jie
WJ
Zhou
Wei-Min
WM
Yan
Wei-Zheng
WZ
Peng
Kun
K
Ruan
Li
L
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology; D045169:Severe Acute Respiratory Syndrome / Q000097:blood / Q000276:immunology* / Q000821:virology
D000914:Antibodies, Viral; D007074:Immunoglobulin G