title: Design and evaluation of a semantic approach for the homogeneous identification of events in eight patient databases: a contribution to the European EU-ADR project.
abstract: The overall objective of the EU-ADR project is the design, development, and validation of a computerised system that exploits data from electronic health records and biomedical databases for the early detection of adverse drug reactions. Eight different databases, containing health records of more than 30 million European citizens, are involved in the project. Unique queries cannot be performed across different databases because of their heterogeneity: Medical record and Claims databases, four different terminologies for coding diagnoses, and two languages for the information described in free text. The aim of our study was to provide database owners with a common basis for the construction of their queries. Using the UMLS, we provided a list of medical concepts, with their corresponding terms and codes in the four terminologies, which should be considered to retrieve the relevant information for the events of interest from the databases.
authors.affiliation: LESIM, ISPED, Uni. Bordeaux 2, France. paul.avillach@isped.u-bordeaux2.fr
authors.forename: Paul
authors.initials: P
authors.lastname: Avillach
authors.forename: Michel
authors.initials: M
authors.lastname: Joubert
authors.forename: Frantz
authors.initials: F
authors.lastname: Thiessard
authors.forename: Gianluca
authors.initials: G
authors.lastname: Trifirò
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Dufour
authors.forename: Antoine
authors.initials: A
authors.lastname: Pariente
authors.forename: Fleur
authors.initials: F
authors.lastname: Mougin
authors.forename: Giovanni
authors.initials: G
authors.lastname: Polimeni
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Catania
authors.forename: Carlo
authors.initials: C
authors.lastname: Giaquinto
authors.forename: Giampiero
authors.initials: G
authors.lastname: Mazzaglia
authors.forename: Carla
authors.initials: C
authors.lastname: Fornari
authors.forename: Ron
authors.initials: R
authors.lastname: Herings
authors.forename: Rosa
authors.initials: R
authors.lastname: Gini
authors.forename: Julia
authors.initials: J
authors.lastname: Hippisley-Cox
authors.forename: Mariam
authors.initials: M
authors.lastname: Molokhia
authors.forename: Lars
authors.initials: L
authors.lastname: Pedersen
authors.forename: Annie
authors.initials: A
authors.lastname: Fourrier-Réglat
authors.forename: Miriam
authors.initials: M
authors.lastname: Sturkenboom
authors.forename: Marius
authors.initials: M
authors.lastname: Fieschi
mesh_terms: D016208:Databases, Factual; D057286:Electronic Health Records; D006801:Humans; D008499:Medical Records; D012660:Semantics; D009626:Terminology as Topic; D017432:Unified Medical Language System