International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?
A meeting was held May 19, 2010 at the Karolinski Institute on Nomenclature in Pharmacology. This meeting occurred in conjunction with the Symposium The Changing World of G Protein Coupled Receptors: From Monomers to Dimers and Receptor Mosaics (Higher-order Oligomers) held the previous day at the Royal Swedish Academy of Science. Two broad topics of nomenclature were discussed; ligand nomenclature and the definition of 'receptor-receptor' interactions. This paper summarizes discussions on these topics along with a consensus definition of the term 'receptor-receptor' interaction.
Kenakin
Terry
T
GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA. terry.p.kenakin@gsk.com
Agnati
Luigi F
LF
Caron
Marc
M
Fredholm
Bertil
B
Guidoli
Diego
D
Kobilka
Brian
B
Lefkowitz
Robert W
RW
Lohse
Martin
M
Woods
Amina
A
Fuxe
Kjell
K
D003226:Congresses as Topic; D006801:Humans; D055503:Protein Multimerization; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013548:Sweden
D043562:Receptors, G-Protein-Coupled