title: Psychometric validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24).
abstract: OBJECTIVE
  A validation study was conducted to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24). This module was designed to assess disease and treatment specific aspects of the quality of life (QoL) of patients with endometrial cancer.
  
  
  METHODS
  Two hundred and sixty-eight women with endometrial cancer were recruited in different phases of treatment: after pelvic surgery (Group 1); during adjuvant chemotherapy and/or radiotherapy (Group 2); after completion of treatment (Group 3). Patients completed the EORTC QLQ-C30, the endometrial cancer module and a short debriefing questionnaire.
  
  
  RESULTS
  Multi-trait scaling analyses confirmed the hypothesised scale structure of the QLQ-EN24. Internal consistency reliability was good with Cronbach's alpha coefficients ranging from 0.74 to 0.86 (lymphoedema 0.80, urological symptoms 0.75, gastrointestinal symptoms 0.74, body image problems 0.86 and sexual/vaginal problems 0.86). Convergent and discriminant validity did not show any scaling errors for the subscales. The QLQ-EN24 module discriminated well between clinically different groups of patients. All items exhibited a high completion rate with less than 2% missing values except for the sexuality items (19%).
  
  
  CONCLUSIONS
  The validation study supports the reliability, the convergent and divergent validity of the EORTC QLQ-EN24. This newly developed QLQ-EN24 module is a useful instrument for the assessment of the QoL in patients treated for endometrial cancer in clinical trials.
authors.affiliation: Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. elfriede.greimel@medunigraz.at
authors.forename: Elfriede
authors.initials: E
authors.lastname: Greimel
authors.forename: Andy
authors.initials: A
authors.lastname: Nordin
authors.forename: Anne
authors.initials: A
authors.lastname: Lanceley
authors.forename: Carien L
authors.initials: CL
authors.lastname: Creutzberg
authors.forename: Lonneke V
authors.initials: LV
authors.lastname: van de Poll-Franse
authors.forename: Vesna Bjelic
authors.initials: VB
authors.lastname: Radisic
authors.forename: Razvan
authors.initials: R
authors.lastname: Galalae
authors.forename: Claudia
authors.initials: C
authors.lastname: Schmalz
authors.forename: Ellen
authors.initials: E
authors.lastname: Barlow
authors.forename: Pernille T
authors.initials: PT
authors.lastname: Jensen
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Waldenström
authors.forename: Karin
authors.initials: K
authors.lastname: Bergmark
authors.forename: Wei-Chu
authors.initials: WC
authors.lastname: Chie
authors.forename: Karin
authors.initials: K
authors.lastname: Kuljanic
authors.forename: Anna
authors.initials: A
authors.lastname: Costantini
authors.forename: Susanne
authors.initials: S
authors.lastname: Singer
authors.forename: Dominique
authors.initials: D
authors.lastname: Koensgen
authors.forename: Usha
authors.initials: U
authors.lastname: Menon
authors.forename: Fedor
authors.initials: F
authors.lastname: Daghofer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000523:psychology*; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008875:Middle Aged; D017060:Patient Satisfaction; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires / Q000592:standards*