title: Small-molecule delivery by nanoparticles for anticancer therapy.
abstract: Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity. Current research in this field focuses on understanding precisely how small molecules are released from nanoparticles and delivered to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field.
authors.affiliation: Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA. gzchen@emory.edu
authors.forename: Zhuo Georgia
authors.initials: ZG
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents