Eucophylline, a Tetracyclic Vinylquinoline Alkaloid from Leuconotis eugenifolius.
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.
Deguchi
Jun
J
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
Shoji
Tomokazu
T
Nugroho
Alfarius E
AE
Hirasawa
Yusuke
Y
Hosoya
Takahiro
T
Shirota
Osamu
O
Awang
Khalijah
K
Hadi
A Hamid A
AH
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053961:Azabicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008296:Malaysia; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry
D000470:Alkaloids; D053961:Azabicyclo Compounds; D026121:Indole Alkaloids; C000603714:eucophylline; C543745:leucophyllidine; D052247:Nitric Oxide Synthase Type II