title: Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
abstract: Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.
authors.affiliation: United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kojima
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kimura
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Akira
authors.initials: A
authors.lastname: Asai
authors.forename: Keiji
authors.initials: K
authors.lastname: Hasumi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oikawa
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa