title: Therapeutic strategies for advanced penile carcinoma.
abstract: OBJECTIVE
  The article will review the treatment of regionally advanced squamous cell carcinoma (SCC) of the penis and will highlight contemporary therapeutic strategies in advanced penile carcinoma.
  
  
  RESULTS
  Advanced penile cancer as defined by bulky inguinal or pelvic metastasis is treated in a systematic fashion by integrating systemic and local therapies. Contemporary series show the morbidity from consolidative surgery has been reduced, whereas the integration of neoadjuvant and adjuvant therapies may provide improved cancer-specific outcomes over single modality treatment. Multiple clinical and pathologic features guide the treatment of advanced disease and aid in determining the appropriate use of neoadjuvant or adjuvant therapies.
  
  
  CONCLUSIONS
  The current treatment of advanced SCC of the penis has evolved to include multimodal treatments for patients with advanced locoregional disease.
authors.affiliation: M.D. Anderson Cancer Center, University of Texas, Houston, Texas, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Delacroix
authors.forename: Curtis A
authors.initials: CA
authors.lastname: Pettaway
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D010412:Penile Neoplasms / Q000473:pathology / Q000628:therapy*