Mn(0)-mediated chemoselective reduction of aldehydes. Application to the synthesis of α-deuterioalcohols.
A mild, simple, safe, chemoselective reduction of different kinds of aldehydes to the corresponding alcohols mediated by the Mn dust/water system is described. In addition to this, the use of D(2)O leads to the synthesis of α-deuterated alcohols and constitutes an efficient, inexpensive alternative for the preparation of these compounds.
Jiménez
Tania
T
Department of Organic Chemistry, Faculty of Sciences, University ofGranada, C. U. Fuentenueva s/n, 18071 Granada, Spain.
Barea
Elisa
E
Oltra
J Enrique
JE
Cuerva
Juan M
JM
Justicia
José
J
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000438:Alcohols; D000447:Aldehydes; D008345:Manganese