title: Tourette's Disorder.
abstract: Tourette's disorder (TD) is a common childhood-onset neuropsychiatric disorder characterized by chronic motor and vocal tics. TD frequently occurs with other neuropsychiatric disorders, such as attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), and may contribute to reduced quality of life and disability. Currently available treatments to reduce tics are limited by variable clinical response and frequent adverse effects. They include alpha-2 agonists, antipsychotics (first and second generation), tetrabenazine, benzodiazepines, and habit reversal therapy. Some new and emerging (but unproven) treatments are also discussed, including topiramate and dopamine agonists. In addition, there is increasing interest in deep brain stimulation, but this is not yet ready for general use.
authors.affiliation: Atlantic Neuroscience Institute, Overlook Hospital, 99 Beauvoir Avenue, Summit, NJ, 07902, USA.
authors.forename: Gholson J
authors.initials: GJ
authors.lastname: Lyon
authors.forename: David
authors.initials: D
authors.lastname: Shprecher
authors.forename: Barbara
authors.initials: B
authors.lastname: Coffey
authors.forename: Roger
authors.initials: R
authors.lastname: Kurlan