title: The state of antibody therapy.
abstract: Therapeutic antibodies are widely used in the treatment of various diseases and disease conditions, including cardiovascular diseases, autoimmune disorders, malignancies, and infections. With at least 23 therapeutic agents currently in clinical use and a successful business generating large revenues, major technological advances are now in place to improve the specificity and efficacy of those antibodies already in the market and also generate new, safe and effective macromolecules for the treatment of other ailments. This review provides a summary of the current state of antibody therapy, highlights and discusses recent developments in the field of antibody-based therapeutics production, combination therapy and shows the status of some of the agents that are in clinical trial.
authors.affiliation: Department of Medical Laboratory Technology, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. aelbakri@sharjah.ac.ae
authors.forename: Ali
authors.initials: A
authors.lastname: Elbakri
authors.forename: Paul N
authors.initials: PN
authors.lastname: Nelson
authors.forename: Raed O
authors.initials: RO
authors.lastname: Abu Odeh
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000235:genetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D051379:Mice
chemical_list: D000911:Antibodies, Monoclonal