title: Growth charts for children with Ellis-van Creveld syndrome.
abstract: Ellis-van Creveld (EvC) syndrome is a congenital malformation syndrome with marked growth retardation. In this study, specific growth charts for EvC patients were derived to allow better follow-up of growth and earlier detection of growth patterns unusual for EvC. With the use of 235 observations of 101 EvC patients (49 males, 52 females), growth charts for males and females from 0 to 20 years of age were derived. Longitudinal and cross-sectional data were collected from an earlier review of growth data in EvC, a database of EvC patients, and from recent literature. To model the growth charts, the GAMLSS package for the R statistical program was used. Height of EvC patients was compared to healthy children using Dutch growth charts. Data are presented both on a scale for age and on a scale for the square root of age. Compared to healthy Dutch children, mean height standard deviation score values for male and female EvC patients were -3.1 and -3.0, respectively. The present growth charts should be useful in the follow-up of EvC patients. Most importantly, early detection of growth hormone deficiency, known to occur in EvC, will be facilitated.
authors.affiliation: Department of Pediatrics, Groene Hart Ziekenhuis, PO Box 1098, Gouda, The Netherlands. sabineverbeek@hotmail.com
authors.forename: Sabine
authors.initials: S
authors.lastname: Verbeek
authors.forename: Paul H C
authors.initials: PH
authors.lastname: Eilers
authors.forename: Kate
authors.initials: K
authors.lastname: Lawrence
authors.forename: Raoul C M
authors.initials: RC
authors.lastname: Hennekam
authors.forename: Florens G A
authors.initials: FG
authors.lastname: Versteegh
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D004613:Ellis-Van Creveld Syndrome / Q000175:diagnosis*; D005260:Female; D057238:Growth Charts; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D019370:Observation; D055815:Young Adult
chemical_list: D013006:Growth Hormone