Substructural hippocampal glucose metabolism observed on PET/MRI.
The hippocampus is one of the best-known neural structures in the brain and has been of interest in observing the substructures and their metabolic functions. However, it has been difficult to distinguish its substructures and functions in vivo because of its small size.


METHODS
(18)F-FDG PET and high-resolution MRI of the hippocampus were performed on 5 healthy subjects using a PET/MRI system. The metabolism of each hippocampal substructure was measured in vivo on the basis of the MR images.


RESULTS
The dentate gyrus and cornu ammonis 4 showed the highest glucose uptake in the healthy subjects.


CONCLUSIONS
Measuring glucose metabolism in the substructures of the hippocampus could provide a new tool for the future investigation of related brain diseases or functional studies, such as Alzheimer disease or memory and learning studies.
Cho
Zang-Hee
ZH
Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-Gu, Incheon, South Korea. zcho@gachon.ac.kr
Son
Young-Don
YD
Kim
Hang-Keun
HK
Kim
Sung-Tae
ST
Lee
Sang-Yoon
SY
Chi
Je-Geun
JG
Park
Chan-Woong
CW
Kim
Young-Bo
YB
D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism*; D006624:Hippocampus / Q000033:anatomy & histology* / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose