Catalysts by the meter: rapid screening approach of N-heterocyclic carbene ligand based catalysts.
Here, we demonstrate a versatile screening platform for NHC ligand based catalysts by coating fused-silica micro capillaries with a bonded 1,3-bismesityl-2-imidazolidinylidene ligand. Such micro capillaries can be efficiently converted into (pre)-catalysts from various organometallic precursors by solid-phase chemistry techniques and can be quantitatively screened using on-column reaction chromatography.
Lang
Carolin
C
Ruprecht-Karls-Universität Heidelberg, Organisch-Chemisches Institut, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Gärtner
Ute
U
Trapp
Oliver
O
D002384:Catalysis; D002845:Chromatography; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D012822:Silicon Dioxide / Q000737:chemistry
D006571:Heterocyclic Compounds; D008024:Ligands; C030011:carbene; D012822:Silicon Dioxide; D008697:Methane