Enantioenriched synthesis of C1-symmetric BINOLs: iron-catalyzed cross-coupling of 2-naphthols and some mechanistic insight.
Highly enantioselective aerobic oxidative cross-coupling of 2-naphthols with broad substrate scope was achieved using an iron(salan) complex as the catalyst. Enantiomeric excesses of the products ranged from 87 to 95%. The scope of the cross-coupling reaction was found to be different from that of the homocoupling reaction under the same reaction conditions.
Egami
Hiromichi
H
Department of Chemistry, Faculty of Science, Graduate School, and Institute for Advanced Study, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Matsumoto
Kenji
K
Oguma
Takuya
T
Kunisu
Takashi
T
Katsuki
Tsutomu
T
D002384:Catalysis; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009284:Naphthols / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D005290:Ferric Compounds; D009284:Naphthols; C028405:2-naphthol