title: Decision modelling of economic evaluation of intervention programme of breast cancer.
abstract: OBJECTIVE
  Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay.
  
  
  METHODS
  We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay.
  
  
  RESULTS
  We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $ 60,000 per quality-adjusted life-year and around 50% for a threshold of $ 100,000.
  
  
  CONCLUSIONS
  The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.
authors.affiliation: Department of Geriatric Health Promotion, College of Healthcare Management, Kainan University, Taoyuan County, Taiwan.
authors.forename: Jung-Chen
authors.initials: JC
authors.lastname: Chang
authors.forename: Tony H-H
authors.initials: TH
authors.lastname: Chen
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Duffy
authors.forename: Amy M-F
authors.initials: AM
authors.lastname: Yen
authors.forename: Sam L-S
authors.initials: SL
authors.lastname: Chen
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality*; D003362:Cost-Benefit Analysis / Q000379:methods; D003661:Decision Support Techniques; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015233:Models, Statistical; D011315:Preventive Medicine; D019057:Quality-Adjusted Life Years; D013624:Taiwan