title: Scaparvin A, a novel caged cis-clerodane with an unprecedented C-6/C-11 bond, and related diterpenoids from the liverwort Scapania parva.
abstract: A novel caged cis-clerodane diterpenoid, scaparvin A, possessing an unprecedented C-6/C-11 bond and a ketal ring, as well as four new cis-clerodane derivatives, scaparvins B-E, were isolated from the Chinese liverwort Scapania parva. Their absolute structures were elucidated by analysis of NMR and CD data coupled with electronic circular dichroism (ECD) calculations. It was proposed that an enzymatic intramolecular aldol reaction was the key step in the biogenetic pathway of scaparvin A.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Dong-Xiao
authors.initials: DX
authors.lastname: Guo
authors.forename: Rong-Xiu
authors.initials: RX
authors.lastname: Zhu
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Li-Ning
authors.initials: LN
authors.lastname: Wang
authors.forename: Shu-Qi
authors.initials: SQ
authors.lastname: Wang
authors.forename: Zhao-Min
authors.initials: ZM
authors.lastname: Lin
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000494:pharmacology; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D045785:Diterpenes, Clerodane; C554706:scaparvin A; D002244:Carbon