Abnormal 1 hour glucose challenge test followed by a normal 3 hour glucose tolerance test: does it identify adverse pregnancy outcome?
OBJECTIVE
To determine if pregnancies with an abnormal glucose challenge test (GCT) but a normal (GTT) are at increased risk for fetal macrosomia or an adverse pregnancy outcome.


METHODS
This prospective observational study matched women with an abnormal glucose challenge test and a normal GTT with the next patient with a normal GCT.


RESULTS
Over 12 months, 107 women with abnormal GCT were matched with 107 women with normal GCT. Women with an abnormal GCT were older (27.3 vs. 24.7, p = 0.001) and less likely to be African-American (OR = 2.2, 95% CI 1.06-4.49) but no more likely to have an adverse pregnancy outcome. ROC curves could not differentiate between macrosomic vs non-macrosomic newborns using GCT values.


CONCLUSIONS
Women with an abnormal GCT but a normal GTT are more likely to be older, less likely to be African-American, but no more likely to have an adverse pregnancy outcome or a macrosomic fetus.
Pugh
Suzanne K
SK
Naval Medical Center, Portsmouth, Virginia, USA.
Poole
Aaron T
AT
Hill
James B
JB
Magann
Everett F
EF
Chauhan
Suneet P
SP
Morrison
John C
JC
D000328:Adult; D001741:Black or African American; D001034:Apgar Score; D020070:Cervical Ripening; D003627:Data Interpretation, Statistical; D005260:Female; D005320:Fetal Macrosomia; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric; D007744:Obstetric Labor Complications / Q000175:diagnosis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D013997:Time Factors