title: [Systemic therapy in the treatment of psoriasis: drugs of prebiological era].
abstract: Psoriasis is a chronic, recurrent skin disease that lasts a whole life. A quarter of adults are suffering from severe forms of psoriasis that requires the application of the systemic treatment. Despite the development of new groups of medicines, traditional therapy is still of great importance. Methotrexate, cyclosporine and acitretin are cost-effective and provide excellent disease control. Methotrexate and acitretin are good choice in terms of maintenance therapy, whereas cyclosporin would ideally be used as intermittent therapy. Fear of serious side effects of traditional drugs can be avoided by setting individualized plan for each patient and careful monitoring.
authors.affiliation: Klinika za kozne i spolne bolesti Medicinskog fakulteta Sveucilista u Rijeci, KBC Rijeka. marijana.kurilic@gmail.com
authors.forename: Marijana
authors.initials: M
authors.lastname: Kurilić
authors.forename: Larisa
authors.initials: L
authors.lastname: Prpić-Massari
authors.forename: Ines
authors.initials: I
authors.lastname: Brajac
authors.forename: Marija
authors.initials: M
authors.lastname: Kastelan
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D016572:Cyclosporine; D017255:Acitretin; D008727:Methotrexate