SERS mapping of nanoparticle labels in single cells using a microfluidic chip.
We report for the first time the time-resolved mapping of intracellular nanoparticle labels from within living cells retained in a microstructured trap using Raman spectroscopy. The methods employed here also demonstrate the ability to rapidly discriminate between cell populations containing different SERS labels.
Syme
Christopher D
CD
Dept. of Electronics & Electrical Engineering, University of Glasgow, Glasgow, G12 8LT, UK.
Sirimuthu
Narayana M S
NM
Faley
Shannon L
SL
Cooper
Jonathan M
JM
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D044085:Microfluidics / Q000295:instrumentation*; D053758:Nanoparticles; D013059:Spectrum Analysis, Raman