title: Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities.
abstract: OBJECTIVE
  This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH).
  
  
  METHODS
  The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms.
  
  
  RESULTS
  Seventy-seven stroke patients (mean WMH volume: 39.5 cm(3)) were recruited. Thirty patients (39%) had ≥ 1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression.
  
  
  CONCLUSIONS
  Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.
authors.affiliation: Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, China. vctmok@cuhk.edu.hk
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
authors.forename: Adrian
authors.initials: A
authors.lastname: Wong
authors.forename: Kelvin
authors.initials: K
authors.lastname: Wong
authors.forename: Winnie C W
authors.initials: WC
authors.lastname: Chu
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Xiong
authors.forename: Anne Y Y
authors.initials: AY
authors.lastname: Chan
authors.forename: Timothy C Y
authors.initials: TC
authors.lastname: Kwok
authors.forename: Xintao
authors.initials: X
authors.lastname: Hu
authors.forename: W K
authors.initials: WK
authors.lastname: Lee
authors.forename: Wai-kwong
authors.initials: WK
authors.lastname: Tang
authors.forename: Ka-sing Lawrence
authors.initials: KS
authors.lastname: Wong
authors.forename: Stephen
authors.initials: S
authors.lastname: Wong
mesh_terms: D000368:Aged; D001284:Atrophy; D002545:Brain Ischemia / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000523:psychology; D003863:Depression / Q000503:physiopathology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D056784:Leukoencephalopathies / Q000473:pathology* / Q000523:psychology*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications / Q000473:pathology* / Q000523:psychology*