Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome.
OBJECTIVE
To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS).


METHODS
This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease.


RESULTS
A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4-73.5 ng/mL) and 10 (0-87.5), respectively. Spearman's correlation coefficient did not show a significant association between MPO levels and Gensini scores (r (s) = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥ 2 × ULN (upper limit of normal), TIMI risk score ≥ 4 and Gensini score in the multivariate analysis.


CONCLUSIONS
Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS.
de Azevedo Lucio
Eraldo
E
Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003 Porto Alegre, RS, Brazil. ealucio@terra.com.br
Gonçalves
Sandro C
SC
Ribeiro
Jorge P
JP
Nunes
Gilberto L
GL
de Oliveira
Jarbas R
JR
Araujo
Gustavo N
GN
Wainstein
Marco V
MV
D054058:Acute Coronary Syndrome / Q000473:pathology*; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology* / Q000473:pathology*; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D012307:Risk Factors
D009195:Peroxidase