title: Streptococcus pneumoniae nasopharyngeal colonization in children in Brasov, Central Romania: high antibiotic resistance and coverage by conjugate vaccines.
abstract: We report high colonization rates among 400 healthy infants and children, and moderate (66%) coverage by PCV7 and PCV10, with a superior (80%) PCV13 coverage. Most frequent serotypes were 23F, 6B, 19F, and 14. Resistance to penicillin, ceftriaxone, erythromycin, and trimethoprim/sulfamethoxazole was 83%, 18%, 62%, and 66%, respectively. 67% isolates were multidrug resistant. Pneumococcal conjugate vaccines covered 80% to 93% of multidrug resistant isolates.
authors.affiliation: Department of Pediatrics, Children's Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania.
authors.forename: Oana
authors.initials: O
authors.lastname: Falup-Pecurariu
authors.forename: Laura
authors.initials: L
authors.lastname: Bleotu
authors.forename: Cristina
authors.initials: C
authors.lastname: Zavarache
authors.forename: Nechama
authors.initials: N
authors.lastname: Peled
authors.forename: Oana
authors.initials: O
authors.lastname: Anton
authors.forename: Michaela
authors.initials: M
authors.lastname: Robu
authors.forename: Cristian
authors.initials: C
authors.lastname: Falup-Pecurariu
authors.forename: Liliana
authors.initials: L
authors.lastname: Rogozea
authors.forename: Nurith
authors.initials: N
authors.lastname: Porat
authors.forename: David
authors.initials: D
authors.lastname: Greenberg
authors.forename: Ron
authors.initials: R
authors.lastname: Dagan
authors.forename: Eugene
authors.initials: E
authors.lastname: Leibovitz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D012383:Romania / Q000453:epidemiology; D012703:Serotyping; D022541:Streptococcal Vaccines / Q000008:administration & dosage*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification*; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D022541:Streptococcal Vaccines; D018074:Vaccines, Conjugate