title: CTX-M-producing Klebsiella spp. in a Brazilian hospital: what has changed in 6 years?
abstract: CTX-M-encoding genes from Klebsiella spp. strains isolated in 2000 and 2006 were characterized as well as their genetic environment. CTX-M-2 variants were predominant in Klebsiella pneumoniae strains, which showed a greater variability in bla(CTX-M) genes, integrons, and plasmids in 2006 when compared to strains collected in 2000. CTX-M-9-producing Klebsiella oxytoca was identified in 2000 as clonal dissemination.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n, Monte Alegre, Ribeirão Preto, SP, Brazil.
authors.forename: Eduardo C
authors.initials: EC
authors.lastname: Clímaco
authors.forename: Luciene A R
authors.initials: LA
authors.lastname: Minarini
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: da Costa Darini
mesh_terms: D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics; D001938:Brazil; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006761:Hospitals; D006801:Humans; D007709:Klebsiella / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism; D007710:Klebsiella Infections / Q000382:microbiology*; D041121:Klebsiella oxytoca / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D010957:Plasmids; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D001618:beta-Lactamases