title: Hydroxyurea-induced foot ulcer in a case of essential thrombocythaemia.
abstract: OBJECTIVE
  To illustrate the association between hydroxyurea and the development of ulcers.
  
  
  METHODS
  A case study is presented, in which histological changes, mean corpuscular volume (MCV) and transcutaneous oxygen tension (TcPO2) were all measured and analysed, both during hydroxyurea treatment and following it's discontinuation.
  
  
  RESULTS
  Two months following the cessation of hydroxyurea therapy, the patient's ulcer had healed completely. Biopsy specimens taken before and after its discontinuation showed a considerable improvement in vascularity, with a capillary density 6.28 times higher after discontinuation of the drug. TcPO2 was just 8mmHg at the first measurement, and this increased to 65mmHg at the second.
  
  
  CONCLUSIONS
  These findings suggest deficient neovascularisation and circulation during hydroxyurea treatment. Changes in MCV also appeared to have an effect on the progress of wound healing, which supports the hypothesis that macroerythrocytosis may be involved in the development of these rare ulcers, via impairment of the microcirculatory rheology.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Saitama Medical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: S
authors.initials: S
authors.lastname: Ichioka
authors.forename: N
authors.initials: N
authors.lastname: Sekiya
mesh_terms: D000368:Aged; D001706:Biopsy; D001785:Blood Gas Monitoring, Transcutaneous; D016903:Drug Monitoring; D004909:Erythrocyte Indices; D005260:Female; D016523:Foot Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D006652:Histological Techniques; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects*; D017592:Skin Care; D013524:Surgical Flaps; D013920:Thrombocythemia, Essential / Q000097:blood / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D006918:Hydroxyurea