title: A prospective examination of the role of childhood sexual abuse and physiological asymmetry in the development of psychopathology.
abstract: OBJECTIVE
  Recent literature has emphasized the simultaneous assessment of multiple physiological stress response systems in an effort to identify biobehavioral risk factors of psychopathology in maltreated populations. The current study assessed whether an asymmetrical stress response, marked by activation in one system and a blunted response in another system, predicted higher levels of psychopathology over time.
  
  
  METHODS
  Data were collected from an ongoing, prospective study of females with a substantiated history of childhood sexual abuse (n=52) and a non-abused comparison group (n=77). Childhood sexual abuse was determined at the initial study visit. Vagal tone and cortisol were measured 7 years later to assess physiological response to a laboratory stressor across these systems. Depressive symptoms and antisocial behaviors were assessed 6 years after the completion of the laboratory stressor.
  
  
  RESULTS
  Structural equation modeling indicated that a prior history of childhood sexual abuse predicted an asymmetrical physiological response to stress in late adolescence. In turn, this asymmetrical response predicted both higher levels of depression and antisocial behaviors in young adulthood.
  
  
  CONCLUSIONS
  Childhood sexual abuse may sensitize females to respond to moderate daily stressors in a manner that places them at higher risk for experiencing depressive symptoms and antisocial behaviors over time.
  
  
  CONCLUSIONS
  The management of mild to moderate stress in the everyday lives of maltreated females may be a particularly useful point of intervention in order to protect against later psychopathology.
authors.affiliation: Division of Behavioral Medicine & Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Chad E
authors.initials: CE
authors.lastname: Shenk
authors.forename: Jennie G
authors.initials: JG
authors.lastname: Noll
authors.forename: Frank W
authors.initials: FW
authors.lastname: Putnam
authors.forename: Penelope K
authors.initials: PK
authors.lastname: Trickett
mesh_terms: D000293:Adolescent; D000987:Antisocial Personality Disorder / Q000209:etiology* / Q000523:psychology; D019540:Area Under Curve; D001341:Autonomic Nervous System / Q000502:physiology; D016022:Case-Control Studies; D002650:Child Abuse, Sexual / Q000175:diagnosis / Q000523:psychology* / Q000706:statistics & numerical data; D003863:Depression / Q000209:etiology* / Q000523:psychology; D004219:District of Columbia; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D011446:Prospective Studies; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological
chemical_list: D006854:Hydrocortisone