title: The impact of glutamine dipeptide-supplemented parenteral nutrition on outcomes of surgical patients: a meta-analysis of randomized clinical trials.
abstract: OBJECTIVE
  To evaluate the impact of glutamine dipeptide-supplemented parenteral nutrition (GLN-PN) on clinical outcomes in surgical patients.
  
  
  METHODS
  MEDLINE, EMBASE, Web of Science, and the Cochrane Controlled Clinical Trials Register were searched to retrieve the eligible studies. The studies were included if they were randomized controlled trials that evaluated the effect of GLN-PN and standard PN on clinical outcomes of surgical patients. Clinical outcomes of interest were postoperative morbidity of infectious complication, mortality, length of hospital stay, and cost. Statistical analysis was conducted by RevMan 4.2 software from the Cochrane Collaboration.
  
  
  RESULTS
  Fourteen randomized controlled trials (RCTs) (N = 587) were included in this meta-analysis. The results showed that glutamine dipeptide significantly reduced the length of hospital stay by around 4 days in the form of alanyl-glutamine (weighted mean difference [WMD] = -3.84; 95% confidence interval [CI] -5.40, -2.28; z = 4.82; P < .001) and about 5 days in the form of glycyl-glutamine (WMD = -5.40; 95% CI -8.46, -2.33; z = 3.45; P < .001). The overall effect indicated a significant decrease in the infectious complication rates of surgical patients receiving GLN-PN (risk ratio = 0.69; 95% CI 0.50, 0.95; z = 2.26; P = .02).
  
  
  CONCLUSIONS
  GLN-PN was beneficial to postoperative patients by shortening the length of hospital stay and reducing the morbidity of postoperative infectious complications.
authors.affiliation: Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhu-Ming
authors.initials: ZM
authors.lastname: Jiang
authors.forename: Marie T
authors.initials: MT
authors.lastname: Nolan
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Hae-Ra
authors.initials: HR
authors.lastname: Han
authors.forename: Kang
authors.initials: K
authors.lastname: Yu
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Jie
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Liang
mesh_terms: D016638:Critical Illness / Q000628:therapy*; D019587:Dietary Supplements; D004151:Dipeptides / Q000627:therapeutic use*; D005973:Glutamine / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D010288:Parenteral Nutrition; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D004151:Dipeptides; D005973:Glutamine