[Effect of cold property Chinese medicine radix scutellariae on energy metabolism of rats].
OBJECTIVE
To observe the effect on energy metabolism of rats with cold property Chinese medicine Radix Scutellariae.


METHODS
The body weight gain, temperature, hydroposia content were determined before administration and every five days after administration. The activities of Na4(+)-K(+)-ATPase, Ca(2+)-ATPase and SDH, LPL, HP, the contents of NEAF, T3, T4, TSH were measured after having been administrated with water extracts of Radix Scutullaxiae at the dose of 6.0, 3.0 g/kg for 43 days.


RESULTS
The body weight gains were raised and the hydroposia contents have been decreased. The activities of SDH were increased significantly while Na(+)-K(+)-ATPase, Ca(2+)-ATPase of liver had little change. The content of NEAF, the activity of LPL, HP were decreased significantly, and the contents of T3, T4, TSH and the body weight, temperature had no significant change.


CONCLUSIONS
Radix Scutellariae can inhibit the energy metabolism of rat. The mechanism may not be related to thyroxine pathway.
Huang
Li-Ping
LP
Jiang Xi College of Traditional Chinese Medicine, Nangchang 330004, China. jxnchlp@163.com
Zhou
Rong
R
Meng
Xiao-Fang
XF
Yu
Ri-Yue
RY
Liu
Hong-Ning
HN
Sun
Jian-Ning
JN
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D031364:Scutellaria baicalensis / Q000737:chemistry*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D014284:Triiodothyronine; D013385:Succinate Dehydrogenase; D008071:Lipoprotein Lipase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D013974:Thyroxine