Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.
New series of 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones (8a-j) and 2,5-disubstituted-1,3,4-thiadiazoles (9a-h) were synthesized by dehydrative cyclization of hydrazinecarbothioamide derivatives (7a-k) by refluxing in 4N aqueous sodium hydroxide and by overnight stirring with polyphosphoric acid, respectively. The structures of the newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR, elemental analysis and mass spectroscopic studies and the synthesized compounds were screened for their antioxidant and urease inhibition activities. N-(2,4-Dimethylphenyl)-5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine (9h) showed excellent antioxidant activity more than the standard drug whereas 4-(2,4-dimethylphenyl)-5-(3-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (8d) and 4-(2,3-dimethylphenyl)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (8e) exhibited potent urease inhibitory activities.
Khan
Imtiaz
I
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Ali
Sajid
S
Hameed
Shahid
S
Rama
Nasim Hasan
NH
Hussain
Muhammad Tahir
MT
Wadood
Abdul
A
Uddin
Reaz
R
Ul-Haq
Zaheer
Z
Khan
Ajmal
A
Ali
Sajjad
S
Choudhary
M Iqbal
MI
D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors*
D000975:Antioxidants; D013830:Thiadiazoles; D014230:Triazoles; D014510:Urease