title: Dynamics of nasal irritation from pulsed homologous alcohols.
abstract: Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1 min. Subjects rated nasal irritation from each pulse using magnitude estimation. Within a trial, compound and concentration were fixed. Compound (ethanol, n-butanol, or n-hexanol) and concentration (4 levels for each compound) varied across trials. For all stimuli, rated irritation decreased over time (adaptation). Plots of log-rated intensity versus elapsed time were approximately linear (intensity decreased by a fixed ratio per unit time). Interestingly, the slopes of intensity versus time functions differed very little: Regardless of concentration and compound, rated irritation decreased by about 32% over the 9 pulses. The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well.
authors.affiliation: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA. pwise@monell.org
authors.forename: Paul M
authors.initials: PM
authors.lastname: Wise
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Wysocki
mesh_terms: D020001:1-Butanol / Q000494:pharmacology*; D000328:Adult; D000438:Alcohols / Q000494:pharmacology; D000704:Analysis of Variance; D005260:Female; D000441:Hexanols / Q000494:pharmacology*; D006801:Humans; D007509:Irritants / Q000494:pharmacology; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects*; D012684:Sensory Thresholds / Q000187:drug effects; D055815:Young Adult
chemical_list: D000438:Alcohols; D000441:Hexanols; D007509:Irritants; C036260:1-hexanol; D020001:1-Butanol