Origin and functional specializations of DC subsets in the lung.
Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg cells or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.
Plantinga
Maud
M
Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, Ghent University, Belgium.
Hammad
Hamida
H
Lambrecht
Bart N
BN
D056704:Adaptive Immunity; D000818:Animals; D017951:Antigen Presentation; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007070:Immunoglobulin A / Q000276:immunology*; D007239:Infections; D008168:Lung / Q000473:pathology*; D008213:Lymphocyte Activation; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058408:Th1-Th2 Balance
D007070:Immunoglobulin A