Methemoglobinemia and dapsone levels in patients with leprosy.
The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.
Vieira
Jose Luiz Fernandes
JL
Pharmacy School, Universidade Federal do Pará, Belém, PA, Brazil. jvieira@ufpa.br
Riveira
Juan Gonzalo Bardarez
JG
Martins
Ana de Nazaré Silva
Ade N
Silva
Jorge Pereira da
JP
Salgado
Claudio Guedes
CG
D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002991:Clofazimine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D056006:Leprosy, Multibacillary / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000175:diagnosis*; D012293:Rifampin / Q000008:administration & dosage; D013053:Spectrophotometry; D055815:Young Adult
D007917:Leprostatic Agents; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin