title: In vitro antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of Balanites aegyptiaca (L.) Del. (Balanitaceae).
abstract: The present study aimed to test the validity of Balanites aegyptiaca remedies used for the treatment of rheumatisms and mental disorders by examining the antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of galls and leaves extracts and fractions. The total phenolics and flavonoids were measured using Folin-Ciocalteu and AlCl3 reagents, respectively. Two methods i.e., FRAP and ABTS were used to estimate the total antioxidant capacity of the plant materials. The FRAP and ABTS antioxidant activities showed that among all extracts and fractions tested, the best antioxidant activities were found with the galls dichloromethane and the leaves ethyl acetate fractions. The antioxidant activities did correlated significantly with the total phenolic and flavonoid contents. The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity comparatively to the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions.
authors.affiliation: Laboratoire de Biochimie et de Chimie Appliquées, UFR/SVT, Université de Ouagadougou, Burkina Faso.
authors.forename: N T R
authors.initials: NT
authors.lastname: Meda
authors.forename: A
authors.initials: A
authors.lastname: Lamien-Meda
authors.forename: M
authors.initials: M
authors.lastname: Kiendrebeogo
authors.forename: C E
authors.initials: CE
authors.lastname: Lamien
authors.forename: A Y
authors.initials: AY
authors.lastname: Coulibaly
authors.forename: J
authors.initials: J
authors.lastname: Millogo-Rasolodimby
authors.forename: O G
authors.initials: OG
authors.lastname: Nacoulma
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D032430:Balanites / Q000737:chemistry / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000378:metabolism*; D005419:Flavonoids / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D010636:Phenols / Q000302:isolation & purification / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism* / Q000627:therapeutic use; D015203:Reproducibility of Results; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D014969:Xanthine Oxidase; D000109:Acetylcholine