Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes.
Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.
Ricci
Jérémy
J
Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
Park
Jeehyun
J
Chung
Won-Yoon
WY
Park
Kwang-Kyun
KK
Jung
Mankil
M
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D037621:Artemisinins / Q000737:chemistry*; D002642:Chick Embryo; D002823:Chorion / Q000187:drug effects*; D006017:Glycolipids / Q000737:chemistry*
D020533:Angiogenesis Inhibitors; D037621:Artemisinins; D006017:Glycolipids; C031327:artemisinin