Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.
The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.
Joyner
P Matthew
PM
Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019, USA.
Liu
Jinman
J
Zhang
Zhijun
Z
Merritt
Justin
J
Qi
Fengxia
F
Cichewicz
Robert H
RH
D015394:Molecular Structure; D005810:Multigene Family; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D013295:Streptococcus mutans / Q000737:chemistry* / Q000235:genetics / Q000254:growth & development
D010456:Peptides, Cyclic; C555906:mutanobactin A