Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium-catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation.
A strategy involving palladium-catalyzed cyclization of halo-phenyl hydrazones and aryl isocyanates provides a convenient approach to the synthesis of 1,3,4-benzotriazepines (4) or 1-arylamide-1H-indazoles (5) in good isolated yields. Microwave irradiation was found to afford high reaction efficiency, while the choice of halophenyl hydrazone had an effect on the pathway of the reaction.
Dong
Chune
C
College of Pharmacy, State Key Laboratory of Virology, Wuhan University, Wuhan, 430071, China. cdong@whu.edu.cn
Xie
Lingli
L
Mou
Xiaohong
X
Zhong
Yashan
Y
Su
Wei
W
D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D017953:Isocyanates / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves; D010165:Palladium / Q000737:chemistry*
D001552:Benzazepines; D006835:Hydrazones; D007191:Indazoles; D017953:Isocyanates; D010165:Palladium