Bioactivities of water-soluble polysaccharides from Jisongrong mushroom: anti-breast carcinoma cell and antioxidant potential.
Polysaccharides were extracted from Jisongrong mushroom. Jisongrong polysaccharides was a water-soluble compound. Its molecular weight was about 7.4×10(4) Da. HPLC analysis showed that this polysaccharides was composed of mannose, ribose, rhamnose, glucose, xylose, galactose and arabinose in the molar contents of 3.3, 17.3, 6.0, 12.4, 98.4 and 2.1 μM, respectively. In the range of 2800-3500 cm(-1), peaks at 2958 and 3407 cm(-1) belonging to -C-H of -CH2 groups, were observed in polysaccharides. When Jisongrong polysaccharides were orally administrated to rats for 2 months, level of lipid peroxidation products and activities of antioxidant enzymes in the blood were significantly decreased and enhanced compared to control rats. Moreover, Jisongrong polysaccharides still markedly inhibited cancer cells proliferation. These results suggested that Jisongrong polysaccharides possess a strong antioxidant and antitumour activities.
Zhou
Lin-Bin
LB
Department of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200011, China.
Chen
Bin
B
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D002374:Catalase / Q000097:blood; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D008297:Male; D008517:Phytotherapy; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D012995:Solubility / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014867:Water / Q000737:chemistry*
D000970:Antineoplastic Agents; D000975:Antioxidants; D011134:Polysaccharides; D017392:Thiobarbituric Acid Reactive Substances; D014867:Water; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione