Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice.
Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.
Teshigawara
Kiyoshi
K
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
Hosaka
Toshio
T
Yamaguchi
Miwa
M
Terada
Eri
E
Kisyuku
Yuka
Y
Fukunaga
Keiko
K
Hirata
Yohko
Y
Jambaldorj
Bayasgalan
B
Harada
Nagakatsu
N
Sakai
Tohru
T
Nakaya
Yutaka
Y
D000818:Animals; D001483:Base Sequence; D001786:Blood Glucose / Q000378:metabolism; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000628:therapy; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D006931:Hyperbaric Oxygenation; D006949:Hyperlipidemias / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D047493:PPAR alpha / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D001786:Blood Glucose; C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D017931:DNA Primers; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D047493:PPAR alpha; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002334:Carnitine O-Palmitoyltransferase