Retroperitoneal solitary fibrous tumor-induced hypoglycemia associated with high molecular weight insulin-like growth factor II.
A man, aged 65 years, presented with frequent episodes of hypoglycemia and unconsciousness. Hypoglycemia was accompanied by undetectable serum insulin and C-peptide levels and a high serum insulin-like growth factor (IGF)-II level. He was found to have a retroperitoneal solitary fibrous tumor. He underwent successful resection of the tumor and had no hypoglycemic episodes after the operation. Immunohistochemical analysis revealed positive immunostaining for IGF-II in tumor cells. The presence of the high-molecular-weight form of IGF-II in the patient's serum was confirmed by immunoblotting, which suggests that his hypoglycemia was due to an increase in the plasma level of IGF-II secreted by the tumor.
Yamakawa-Yokota
Fumiko
F
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Ozaki
Nobuaki
N
Okajima
Akiko
A
Nishio
Hideki
H
Nagasaka
Tetsuro
T
Oiso
Yutaka
Y
D000368:Aged; D002096:C-Peptide / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D007328:Insulin / Q000097:blood; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D011859:Radiography; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D014474:Unconsciousness / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery
D002096:C-Peptide; D007328:Insulin; D009363:Neoplasm Proteins; D007335:Insulin-Like Growth Factor II