title: Use of duraseal in repair of cerebrospinal fluid leaks.
abstract: OBJECTIVE
  The purpose of our article is to review the use of the DuraSeal Sealant System (Confluent Surgical Inc., Waltham, MA) in the repair of complex cerebrospinal fluid (CSF) leaks in endoscopic skull-base surgery.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  London Health Sciences Centre.
  
  
  METHODS
  A database of endoscopic skull-base cases between 2007 and 2009 that involved CSF leakage repaired with DuraSeal was created. Demographic data and operative reports were collected and analyzed qualitatively.
  
  
  METHODS
  Recurrence of CSF leak after repair.
  
  
  RESULTS
  Five cases were identified that met study criteria. In four of the five cases, the repair was successful. There were no complications related to DuraSeal use. Comparison to a subset of patients using Tisseel Fibrin Sealant (Baxter, Toronto, ON) for repair did not show a significant difference in failure rate (χ2 = 0.029, p = .858).
  
  
  CONCLUSIONS
  There are a variety of techniques described to repair CSF rhinorrhea, with various studies demonstrating the advantages of using tissue glues in CSF leak repairs. We used DuraSeal in five patients to enhance graft strength and form a watertight seal. The system was effective in the majority of patients. Our study is the first to report on endoscopic endonasal repair of CSF leaks using DuraSeal.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, 268 Grosvenor Street, London, ON N6A 4V2. brian.rotenberg@sjhc.london.on.ca
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Chin
authors.forename: Lukas
authors.initials: L
authors.lastname: Kus
authors.forename: Brian W
authors.initials: BW
authors.lastname: Rotenberg
mesh_terms: D000293:Adolescent; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012117:Resins, Synthetic / Q000494:pharmacology*; D055502:Secondary Prevention
chemical_list: D012117:Resins, Synthetic; C030189:Dura-Seal