In vitro and in vivo lung deposition of coated magnetic aerosol particles.
The magnetic induced deposition of polydispersed aerosols composed of agglomerated superparamagnetic particles was measured with an in vitro model system and in the mouse trachea and deep lung for the purpose of investigating the potential of site specific respiratory drug delivery. Oleic acid coated superparamagnetic particles were prepared and characterized by TEM, induced magnetic moment, and iron content. The particles were dispersed in cyclohexane, aerosolized with an ultrasonic atomizer and dried by sequential reflux and charcoal columns. The fraction of iron deposited on glass tubes increased with particle size and decreasing flow rate. High deposition occurred with a small diameter tube, but the deposition fraction was largely independent of tube size at larger diameters. Results from computational fluid dynamics qualitatively agreed with the experimental results. Enhanced deposition was observed in the mouse lung but not in the trachea consistent with the analysis of the aerodynamic time allowed for deposition and required magnetic deposition time.
Xie
Yuanyuan
Y
Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
Longest
P Worth
PW
Xu
Yun Hao
YH
Wang
Jian Ping
JP
Wiedmann
Timothy Scott
TS
D000280:Administration, Inhalation; D000336:Aerosols / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D008168:Lung / Q000378:metabolism*; D008280:Magnetics; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D019301:Oleic Acid / Q000737:chemistry*; D010316:Particle Size; D014018:Tissue Distribution; D014132:Trachea / Q000378:metabolism*
D000336:Aerosols; D005290:Ferric Compounds; C000499:ferric oxide; D019301:Oleic Acid