[Design and synthesis of novel PPARgamma agonists].
OBJECTIVE
To design and synthesize novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.


METHODS
A series of novel PPARgamma agonists were designed based on the binding character of PPARgamma agonists and the distribution of pharmacophore. The target compounds were synthesized using p-hydroxybenzaldehyde, 1, 2-dibromoethane, phenol, hydantoin and 2-thiohydantoin as materials.


RESULTS
Twelve compounds were synthesized by etherification and Knoevenagle condensation.


CONCLUSIONS
The target compounds were efficiently synthesized under mild condition and the structures of the target compounds were confirmed by 1HNMR and MS.
Chen
Tao
T
Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Jiang
Bo
B
Guo
Li
L
D001547:Benzaldehydes / Q000737:chemistry; D015195:Drug Design; D015946:Ethylene Dibromide / Q000737:chemistry; D006827:Hydantoins / Q000737:chemistry; D047495:PPAR gamma / Q000819:agonists*
D001547:Benzaldehydes; D006827:Hydantoins; D047495:PPAR gamma; D015946:Ethylene Dibromide; C011483:4-hydroxybenzaldehyde