title: Designing HPMC matrices with improved resistance to dissolved sugar.
abstract: High concentrations of dissolved sugars can accelerate in vitro drug release in certain hydroxypropyl methylcellulose (HPMC) matrices (Williams et al., 2009). This study investigated the potential for common formulation variables to modulate sucrose sensitivity, and explored if more resistant formulations could be designed. In a model matrix containing 30% HPMC (Methocel™ K4M), the inclusion of sugar as a tablet diluent was a key factor. Lactose:microcrystalline cellulose mixtures, dextrose and d-xylose all produced highly swollen, erodible matrices in 0.7M sucrose (37°C), which collapsed and rapidly released remaining drug after 1-4h. This suggests internal and external sugars combine to disrupt the diffusion barrier properties of the gel layer. In contrast, matrices containing microcrystalline cellulose as the sole diluent provided extended release for 10h. Small particle size (<63μm) and high or low viscosity HPMC (Methocel™ K100M or K100LV) also improved sugar resistance. Knowledge of these variables allowed a significantly more resistant HPMC matrix to be designed which provided extended release for >16h in 0.9M sucrose. By judicious selection of excipient properties, the tolerance of HPMC matrices to high sucrose environments can be significantly improved.
authors.affiliation: Formulation Insights, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Hywel D
authors.initials: HD
authors.lastname: Williams
authors.forename: Robert
authors.initials: R
authors.lastname: Ward
authors.forename: Anna
authors.initials: A
authors.lastname: Culy
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Hardy
authors.forename: Colin D
authors.initials: CD
authors.lastname: Melia
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives; D007785:Lactose / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013395:Sucrose / Q000737:chemistry*; D013607:Tablets; D014783:Viscosity
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D065347:Hypromellose Derivatives; D013395:Sucrose; D008747:Methylcellulose; D007785:Lactose