title: Lopinavir/ritonavir dosage form affects quality of life during monotherapy in HIV-positive adults.
abstract: This was a single-center, open-label study of lopinavir/ritonavir (LPV/r) single-agent therapy in antiretroviral-naive, HIV-infected participants initiating therapy with twice-daily soft-gelatin capsules (SGC) and switched to tablets after ≥4 weeks. The objective was to evaluate quality of life and tolerability of the 2 formulations. Participants quality of life, depression, and tolerability were measured using the Medical Outcomes Study-HIV (MOS-HIV), Modified Global Condition Improvement (GCI), and Center for Epidemiologic Studies-Depression (CES-D), prior to and 4 weeks following switch. MOS-HIV showed significant improvements in general health perception (+6 (16), mean (SD); P = .047) and role functioning (+8 (19), mean (SD); P = .023) post-switch. GCI showed significant improvement in ease of taking medications with tablets (56.7% vs 83.3%; P = .021). No change was observed in CES-D. Tolerability improved in 47%. Reported diarrhea (grade 2) was higher during SGC (33.3% vs3.3%; P = .004). Quality-of-life measures, tolerability, and diarrhea improved with the LPV/r tablet formulation compared to SGC in HIV-positive patients not receiving other antiretroviral therapy (ART).
authors.affiliation: University of Houston, College of Pharmacy, Houston, TX, USA.
authors.forename: Rosa F
authors.initials: RF
authors.lastname: Yeh
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Lipman
authors.forename: Carl
authors.initials: C
authors.lastname: Mayberry
authors.forename: Bernie
authors.initials: B
authors.lastname: Miguel
authors.forename: John J
authors.initials: JJ
authors.lastname: Nemecek
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Gathe
mesh_terms: D000293:Adolescent; D000328:Adult; D002214:Capsules; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D061466:Lopinavir; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D011744:Pyrimidinones / Q000008:administration & dosage* / Q000009:adverse effects; D011788:Quality of Life; D019438:Ritonavir / Q000008:administration & dosage* / Q000009:adverse effects; D013607:Tablets
chemical_list: D002214:Capsules; D004338:Drug Combinations; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D013607:Tablets; D061466:Lopinavir; D019438:Ritonavir