Birth defects after assisted reproductive technologies in China: analysis of 15,405 offspring in seven centers (2004 to 2008).
This first large-scale report of birth defects in 15,405 offspring conceived by assisted reproductive technologies in China found infants born after IVF alone to have a birth defect frequency comparable to that in the general Chinese population; rates were nonsignificantly higher in infants conceived with use of intracytoplasmic sperm injection compared with those conceived after IVF alone.
Yan
Junhao
J
Center for Reproductive Medicine, Shandong University, Jinan, People's Republic of China.
Huang
Guoning
G
Sun
Yingpu
Y
Zhao
Xiaoming
X
Chen
Shiling
S
Zou
Shuhua
S
Hao
Cuifang
C
Quan
Song
S
Chen
Zi-Jiang
ZJ
D002681:China / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000453:epidemiology*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D007317:Insemination, Artificial, Homologous / Q000009:adverse effects / Q000706:statistics & numerical data; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects* / Q000706:statistics & numerical data*; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects / Q000706:statistics & numerical data