DNA Core@Inorganic Shell.
A chemically well-defined Bio Core@Inorganic Shell nanohybrid, which consists of rationally designed DNA molecule core with a size of ∼100 nm and spherical inorganic nanoshell with an overall thickness of ∼10 nm reassembled with exfoliated layered metal hydroxide (MH nanosheets), is prepared. The DNA encapsulation and its release, due to the pH-dependent solubility of the MH nanoshell, plays a crucial role in maximizing the stability of base sequence-manipulated and probe-functionalized DNA molecules with designed information. The present DNA Core@MH Shell nanohybrid can provide wide bioinspired applications converged with nanotechnology, such as an advanced gene delivery system and a biomedical diagnostics, tracing/collection/sensing system for DNA-based information.
Park
Dae-Hwan
DH
Center for Intelligent NanoBio Materials (CINBM), Ewha Womans University, Seoul 120-750, Korea.
Kim
Jung-Eun
JE
Oh
Jae-Min
JM
Shul
Yong-Gun
YG
Choy
Jin-Ho
JH
D004247:DNA / Q000737:chemistry*; D006878:Hydroxides / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008853:Microscopy; D008958:Models, Molecular; D057145:Nanoshells / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D014961:X-Ray Diffraction
D006878:Hydroxides; D008670:Metals; D004247:DNA