title: Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity.
abstract: Several derivatives containing dihydronaphtho, naphtho[2,1-b]thiophene and thieno[2,3-d]pyrimidine ring systems were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile (1). Structure characterization of the thioxo derivative 7 was also performed and its reaction with some chloro and bromoalkyl reagents was studied. Moreover, the prepared products were tested for antiviral activity against H5N1 virus [A/chicken/Egypt/1/2006 (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on MDCK cells. Compounds 5, 7 and 8 showed the highest effect compared with the other tested compounds.
authors.affiliation: Photochemistry Department, National Research Center, Behos street, Dokki, Cairo, Egypt. aymnelzeny@yahoo.com
authors.forename: Aymn E
authors.initials: AE
authors.lastname: Rashad
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Shamroukh
authors.forename: Randa E
authors.initials: RE
authors.lastname: Abdel-Megeid
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mostafa
authors.forename: Rabeh
authors.initials: R
authors.lastname: el-Shesheny
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kandeil
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ali
authors.forename: Klaus
authors.initials: K
authors.lastname: Banert
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D011743:Pyrimidines; D013876:Thiophenes; C476003:thienopyrimidine