The state of the art of residue analysis: the 6th VDRA symposium 2010.
Since the onset of residue analysis (ca 40 years ago) a lot of attention has been paid to the amelioration of analytical methods, for example, lowering the limits of detection (LOD) and limits of quantification (LOQ) or decision limits (CCα) and detection capabilities (CCβ), including an increase in the number of analytes, shortening runtimes, increasing sample throughput, amongst others. The state of the art in residue analysis, which was presented at the VDRA 2010 symposium (Hormone and Veterinary Drug Residue Analysis) in Ghent is reviewed in this article. From an analytical point of view, the use of ultra high performance liquid chromatography (UHPLC) hyphenated with accurate mass spectrometry is often used in combination with other (biological) detection systems and 'omic' approaches. Through these techniques more xenobiotic substances turn out to be naturally occurring in some matrices and/or circumstances (e.g. thiouracil, chloramphenicol and semicarbazide).
De Brabander
H F
HF
Ghent University, Department of Veterinary Public Health and Food Safety, Salisburylaan, Merelbeke, Belgium. Hubert.DeBrabander@UGent.be
Vanden Bussche
J
J
Wille
K
K
Bekaert
K
K
Vanhaecke
L
L
D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis*; D057230:Limit of Detection; D013058:Mass Spectrometry; D019155:Veterinary Drugs / Q000032:analysis*
D019155:Veterinary Drugs