Methicillin-resistant Staphylococcus aureus colonization in HIV-infected outpatients is common and detection is enhanced by groin culture.
SUMMARYAlthough high rates of clinical infection with methicillin-resistant Staphylococcus aureus (MRSA) have been reported in HIV-infected adults, data on MRSA colonization are limited. We enrolled HIV-infected adults receiving care at the Atlanta VA Medical Center. Swabs from each participant's nares and groin were cultured with broth enrichment for S. aureus. Of 600 HIV-infected adults, 79 (13%) were colonized with MRSA and 180 (30%) with methicillin-susceptible S. aureus. MRSA pulsed-field gel electrophoresis types USA300 (n=44, 54%) and USA500/Iberian (n=29, 35%) predominated. Inclusion of groin swabs increased MRSA detection by 24% and USA300 detection by 38%. In multivariate analysis, MRSA colonization compared to no MRSA colonization was associated with a history of MRSA clinical infection, rarely or never using condoms, and contact with prisons and jails. In summary, the prevalence of MRSA colonization was high in this study of HIV-infected adults and detection of USA300 was enhanced by groin culture.
Peters
P J
PJ
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Brooks
J T
JT
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Limbago
B
B
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lowery
H K
HK
Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
McAllister
S K
SK
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Mindley
R
R
Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
Fosheim
G
G
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gorwitz
R J
RJ
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Guest
J L
JL
Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
Hageman
J
J
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Fridge
J
J
Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
Rimland
D
D
Veterans Affairs Medical Center (VAMC), Atlanta, GA, USA.
D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006119:Groin / Q000382:microbiology*; D015658:HIV Infections / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology