title: Chronic Kidney Disease Epidemiology Collaboration versus Modification of Diet in Renal Disease equations for renal function evaluation in patients undergoing partial nephrectomy.
abstract: OBJECTIVE
  A novel equation, the Chronic Kidney Disease Epidemiology Collaboration, has been proposed to replace the Modification of Diet in Renal Disease for estimated glomerular filtration rate due to higher accuracy, particularly in the setting of normal renal function. We compared these equations in patients with 2 functioning kidneys undergoing partial nephrectomy.
  
  
  METHODS
  We assembled a cohort of 1,158 patients from 5 institutions who underwent partial nephrectomy between 1991 and 2009. Only subjects with 2 functioning kidneys were included in the study. The end points were baseline estimated glomerular filtration rate, last followup estimated glomerular filtration rate (3 to 18 months), absolute and percent change estimated glomerular filtration rate ([absolute change/baseline] × 100%), and proportion of newly developed chronic kidney disease stage III. The agreement between the equations was evaluated using Bland-Altman plots and the McNemar test for paired observations.
  
  
  RESULTS
  Mean baseline estimated glomerular filtration rate derived from the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration equations were 73 and 77 ml/minute/1.73 m(2), respectively, and following surgery were 63 and 67 ml/minute/1.73 m(2), respectively. Mean percent change estimated glomerular filtration rate was -12% for both equations (p = 0.2). The proportion of patients with newly developed chronic kidney disease stage III following surgery was 32% and 25%, according to the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration equations, respectively (p = 0.001).
  
  
  CONCLUSIONS
  For patients with 2 functioning kidneys undergoing partial nephrectomy the Chronic Kidney Disease Epidemiology Collaboration equation provides slightly higher glomerular filtration rate estimates compared to the Modification of Diet in Renal Disease equation, with 7% fewer patients categorized as having chronic kidney disease stage III or worse.
authors.affiliation: Section of Urology, University of Chicago, Chicago, Illinois, USA.
authors.forename: Sergey
authors.initials: S
authors.lastname: Shikanov
authors.forename: Melanie A
authors.initials: MA
authors.lastname: Clark
authors.forename: Jay D
authors.initials: JD
authors.lastname: Raman
authors.forename: Benjamin
authors.initials: B
authors.lastname: Smith
authors.forename: Matthew
authors.initials: M
authors.lastname: Kaag
authors.forename: Paul
authors.initials: P
authors.lastname: Russo
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Wheat
authors.forename: J Stuart
authors.initials: JS
authors.lastname: Wolf
authors.forename: William C
authors.initials: WC
authors.lastname: Huang
authors.forename: Arieh L
authors.initials: AL
authors.lastname: Shalhav
authors.forename: Scott E
authors.initials: SE
authors.lastname: Eggener
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000601:surgery*; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D055815:Young Adult