title: Selective atrophy of the middle hepatic venous drainage area in hepatitis C-related cirrhotic liver: morphometric study by using multidetector CT.
abstract: OBJECTIVE
  To retrospectively analyze the morphologic changes of hepatitis C-related cirrhosis, which commonly show macronodular cirrhosis, in relation to the portal venous supply and hepatic venous drainage, by using multidetector computed tomographic volumetry.
  
  
  METHODS
  Institutional ethics committee approval and informed consent were obtained. The volume of the entire liver, each portal segment, and hepatic venous drainage area with the respective proportion relative to the entire liver and the volume of hepatic area with the respective proportion relative to the anterior segment of the right lobe were measured in 74 patients without cirrhosis and with normal liver function and in 64 patients with cirrhosis classified as Child-Pugh class A and in 68 with that classified as Child-Pugh class B. The diameter and length of each hepatic vein were measured in normal liver. All measurements were statistically analyzed by using the Kruskal-Wallis test, and multiple comparisons were made by using a Bonferroni correction (P < .05).
  
  
  RESULTS
  The entire liver volume was significantly smaller in patients with Child-Pugh class B cirrhosis (P = .002), whereas there was no significant difference in volume between the normal liver and the liver with Child-Pugh class A cirrhosis (P > .99). Middle hepatic venous (MHV) drainage area revealed significant atrophy in cirrhosis (P < .0001), more markedly in Child-Pugh class B. The right hepatic venous (RHV) and left hepatic venous drainage areas showed significant hypertrophy in cirrhosis (P < .0001). The anterior and medial segments showed significant atrophy (P < .0001), and the lateral and posterior segments and caudate lobe showed significant hypertrophy in cirrhosis (P < .05). In the anterior segment, the MHV drainage area showed significant atrophy (P < .0001), and the RHV drainage area demonstrated relative hypertrophy in cirrhosis, more definitely in Child-Pugh class B. The diameter of MHV was significantly the smallest (P < .0001), and the length of MHV was relatively longer in normal livers.
  
  
  CONCLUSIONS
  The morphologic changes in hepatitis C-related cirrhosis (mainly macronodular cirrhosis) were attributed to a selective volume reduction of the MHV drainage area and relative enlargement of the other areas.
authors.affiliation: Department of Radiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. ozaki@rad.m.kanazawa-u.ac.jp
authors.forename: Kumi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsui
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Junichiro
authors.initials: J
authors.lastname: Sanada
authors.forename: Wataru
authors.initials: W
authors.lastname: Koda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Minami
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Gabata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006503:Hepatic Veins / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol