title: Angiopoietins, abdominal aortic aneurysm and atherosclerosis.
abstract: Abdominal aortic aneurysm (AAA) and atherosclerosis are common causes of mortality and morbidity in an aging population. Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis. Angpts can also influence inflammation and have been shown to possess both pro-atherosclerotic and atheroprotective effects. This review explores the potential roles that the angpts play in the development and progression of AAA and atherosclerosis.
authors.affiliation: The Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Douglas Campus, Townsville, QLD 4811, Australia.
authors.forename: Alexandra F
authors.initials: AF
authors.lastname: Trollope
authors.forename: Jonathan
authors.initials: J
authors.lastname: Golledge
mesh_terms: D042682:Angiopoietins / Q000378:metabolism*; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D042682:Angiopoietins; D018836:Inflammation Mediators