title: Morphological changes in porcine bioprosthetic valves of a HeartMate left ventricular assist device.
abstract: A 27-year-old man who received a HeartMate (Thoratec Corporation, USA) left ventricular assist device for progressive heart failure as a bridge to orthotopic heart transplantation is described in the present report. The device failed (mechanical failure) after almost 19 months. The porcine bioprosthetic valves in the inflow and outflow cannulae showed hemorrhage, cusp tears and inflammatory cells, located largely on the inflow valve cusps. The role of the inflammatory cell reaction in the bioprosthetic valve is discussed.
authors.affiliation: Department of Pathology, Toronto General Hospital, University of Toronto, Ontario.
authors.forename: Nasir A
authors.initials: NA
authors.lastname: Khan
authors.forename: Jagdish
authors.initials: J
authors.lastname: Butany
authors.forename: Taylor
authors.initials: T
authors.lastname: Zhou
authors.forename: Shaun
authors.initials: S
authors.lastname: Leong
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
authors.forename: Heather
authors.initials: H
authors.lastname: Ross
mesh_terms: D000328:Adult; D000818:Animals; D001705:Bioprosthesis / Q000009:adverse effects*; D006333:Heart Failure / Q000601:surgery*; D016027:Heart Transplantation / Q000379:methods; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006351:Heart Valves / Q000473:pathology*; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D011475:Prosthesis Failure; D016896:Treatment Outcome