title: Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.
abstract: Several genes have been suggested as dyslexia candidates. Some of these candidate genes have been recently shown to be associated with literacy measures in sample cohorts derived from the general population. Here, we have conducted an association study in a novel sample derived from the Australian population (the Raine cohort) to further investigate the role of dyslexia candidate genes. We analysed markers, previously reported to be associated with dyslexia, located within the MRPL19/C2ORF3, KIAA0319, DCDC2 and DYX1C1 genes in a sample of 520 individuals and tested them for association with reading and spelling measures. Association signals were detected for several single nucleotide polymorphisms (SNPs) within DYX1C1 with both the reading and spelling tests. The high linkage disequilibrium (LD) we observed across the DYX1C1 gene suggests that the association signal might not be refined by further genetic mapping.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom. silviap@well.ox.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Paracchini
authors.forename: Q W
authors.initials: QW
authors.lastname: Ang
authors.forename: F J
authors.initials: FJ
authors.lastname: Stanley
authors.forename: A P
authors.initials: AP
authors.lastname: Monaco
authors.forename: C E
authors.initials: CE
authors.lastname: Pennell
authors.forename: A J O
authors.initials: AJ
authors.lastname: Whitehouse
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008137:Longitudinal Studies; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011932:Reading
chemical_list: D003598:Cytoskeletal Proteins; C478878:DNAAF4 protein, human; D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins