title: International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?
abstract: A meeting was held May 19, 2010 at the Karolinski Institute on Nomenclature in Pharmacology. This meeting occurred in conjunction with the Symposium The Changing World of G Protein Coupled Receptors: From Monomers to Dimers and Receptor Mosaics (Higher-order Oligomers) held the previous day at the Royal Swedish Academy of Science. Two broad topics of nomenclature were discussed; ligand nomenclature and the definition of 'receptor-receptor' interactions. This paper summarizes discussions on these topics along with a consensus definition of the term 'receptor-receptor' interaction.
authors.affiliation: GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA. terry.p.kenakin@gsk.com
authors.forename: Terry
authors.initials: T
authors.lastname: Kenakin
authors.forename: Luigi F
authors.initials: LF
authors.lastname: Agnati
authors.forename: Marc
authors.initials: M
authors.lastname: Caron
authors.forename: Bertil
authors.initials: B
authors.lastname: Fredholm
authors.forename: Diego
authors.initials: D
authors.lastname: Guidoli
authors.forename: Brian
authors.initials: B
authors.lastname: Kobilka
authors.forename: Robert W
authors.initials: RW
authors.lastname: Lefkowitz
authors.forename: Martin
authors.initials: M
authors.lastname: Lohse
authors.forename: Amina
authors.initials: A
authors.lastname: Woods
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
mesh_terms: D003226:Congresses as Topic; D006801:Humans; D055503:Protein Multimerization; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013548:Sweden
chemical_list: D043562:Receptors, G-Protein-Coupled