Lactobacillus rhamnosus meningitis following recurrent episodes of bacteremia in a child undergoing allogeneic hematopoietic stem cell transplantation.
We report a case of meningitis due to Lactobacillus rhamnosus in a child undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia. Four episodes of bacteremia involving strains with pulsotypes identical to that of the cerebrospinal fluid isolate preceded meningitis. After several courses of clindamycin, no relapse occurred during the patient follow-up.
Robin
Frédéric
F
CHU Clermont-Ferrand, Laboratoire de Bactériologie Clinique, Clermont-Ferrand F-63003, France. frobin@chu-clermontferrand.fr
Paillard
Catherine
C
Marchandin
Hélène
H
Demeocq
François
F
Bonnet
Richard
R
Hennequin
Claire
C
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000382:microbiology; D015373:Bacterial Typing Techniques; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D052201:Lacticaseibacillus rhamnosus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008969:Molecular Sequence Data; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012008:Recurrence; D017422:Sequence Analysis, DNA; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D002981:Clindamycin