title: No efficacy of processed Fabuless (Olibra) in suppressing appetite or food intake.
abstract: OBJECTIVE
  To investigate the feasibility of Fabuless (previously called Olibra and Reducal) as a food ingredient for food intake and appetite reduction, by assessing the effects of food processing on efficacy.
  
  
  METHODS
  In total, 24 healthy volunteers (16 female, 8 male; age: 18-43 years; body mass index: 18-37 kg/m(2)) took part in a randomized, placebo-controlled, double-blinded, cross-over trial. Yoghurt-based meal replacement drinks (containing processed or unprocessed Fabuless, or a control fat) were followed by an ad libitum lunch and evening meal (dinner). Key outcome measures were energy intake and self-reported appetite ratings.
  
  
  RESULTS
  Compared with control, only unprocessed Fabuless reduced subsequent energy intake, although only during dinner (P < 0.01; control, processed and unprocessed: 4.3, 3.9 and 4.2 MJ, respectively) and not during lunch (3.6, 3.7 and 3.6 MJ). Self-reported appetite scores did not differ between treatments.
  
  
  CONCLUSIONS
  Although modest effects of unprocessed Fabuless were seen on food intake, but not on appetite, the ingredient was not robust to common food-manufacturing processes (thermal and shear processing). Claims on reduced food intake and appetite relating to this ingredient in food products are, therefore, only valid if functionality has been demonstrated after all relevant processing and storage steps.
authors.affiliation: Functional Food Centre, Oxford Brookes University, Oxford, UK. hsmit@brookes.ac.uk
authors.forename: H J
authors.initials: HJ
authors.lastname: Smit
authors.forename: E
authors.initials: E
authors.lastname: Keenan
authors.forename: E M R
authors.initials: EM
authors.lastname: Kovacs
authors.forename: S A
authors.initials: SA
authors.lastname: Wiseman
authors.forename: H P F
authors.initials: HP
authors.lastname: Peters
authors.forename: D J
authors.initials: DJ
authors.lastname: Mela
authors.forename: P J
authors.initials: PJ
authors.lastname: Rogers
mesh_terms: D000293:Adolescent; D000328:Adult; D001067:Appetite Depressants / Q000494:pharmacology*; D001069:Appetite Regulation; D015992:Body Mass Index; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating; D002149:Energy Intake; D005260:Female; D005502:Food; D005511:Food Handling; D006801:Humans; D008297:Male; D012528:Satiety Response; D057566:Self Report; D015014:Yogurt; D055815:Young Adult
chemical_list: D001067:Appetite Depressants