title: Is long-term bisphosphonate therapy associated with benefits to the periodontium in postmenopausal women?
abstract: OBJECTIVE
  The aim of this study was to compare the periodontium of postmenopausal women with known low bone mineral density who are receiving long-term bisphosphonate therapy with those who are not.
  
  
  METHODS
  The periodontal status of 28 white postmenopausal women with low bone density using bisphosphonate therapy for at least 2 years was compared with that of a matching group not using such therapy. All women underwent a cone-beam CT scan of the jaw and a complete periodontal examination evaluating for plaque score, periodontal probing depth, clinical attachment loss, bleeding on probing, and alveolar bone height.
  
  
  RESULTS
  Bisphosphonate users had higher plaque score, lower probing depth, and lesser clinical attachment loss compared with the controls. These differences were determined to be significant by both t test and Wilcoxon's tests. Bleeding on probing was lower and the alveolar bone height was higher in the bisphosphonate group than in controls, but these differences were not statistically significant. Linear models showed no significant interactions between plaque score and bisphosphonate use, suggesting that the association of periodontal status and outcome measures was constant across all levels of plaque scores. Bisphosphonate use was a significant factor for probing depth but was not significant for the other parameters when adjusted for plaque score.
  
  
  CONCLUSIONS
  Long-term bisphosphonate use seems to have some beneficial effects on the periodontium of postmenopausal women with low bone density, across all levels of plaque score.
authors.affiliation: Case Western School of Dental Medicine, Cleveland, OH 44106, USA. leena.palomo@case.edu
authors.forename: Leena
authors.initials: L
authors.lastname: Palomo
authors.forename: Maria Clarinda A
authors.initials: MC
authors.lastname: Buencamino-Francisco
authors.forename: John J
authors.initials: JJ
authors.lastname: Carey
authors.forename: Mala
authors.initials: M
authors.lastname: Sivanandy
authors.forename: Holly
authors.initials: H
authors.lastname: Thacker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D054893:Cone-Beam Computed Tomography; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D010519:Periodontium / Q000000981:diagnostic imaging* / Q000187:drug effects*; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates