Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells.
Growing evidence indicates that collagens perform crucial functions during the development and organization of the nervous system. Collagen XXVIII is a recently discovered collagen almost exclusively expressed in the peripheral nervous system (PNS). In this study, we show that this collagen is associated with nonmyelinated regions of the PNS. With the notable exception of type II terminal Schwann cell in the hairy skin, collagen XXVIII surrounds all nonmyelinating glial cells studied. This includes satellite glial cells of the dorsal root ganglia, terminal Schwann cells type I around mechanoceptors in the skin, terminal Schwann cells around proprioceptors in the muscle spindle or at the neuromuscular junction and olfactory ensheathing cells. Collagen XXVIII is also detected at nodes of Ranvier where the myelin sheath of myelinated fibers is interrupted and is thus a distinctive component of the PNS nodal gap. The correlation between the absence of myelin and the presence of collagen XXVIII is confirmed in a mouse model of Charcot-Marie-Tooth characterized by dysmyelinated nerve fibers, in which enhancement of collagen XXVIII labeling is observed.
Grimal
Sophie
S
INSERM U583, Institut des Neurosciences de Montpellier, Université Montpellier II Hôpital Saint Eloi, 80 rue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5.
Puech
Sylvie
S
Wagener
Raimund
R
Ventéo
Stéphanie
S
Carroll
Patrick
P
Fichard-Carroll
Agnès
A
D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D002478:Cells, Cultured; D002607:Charcot-Marie-Tooth Disease / Q000473:pathology / Q000503:physiopathology*; D003094:Collagen / Q000235:genetics* / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D036421:Nerve Fibers, Unmyelinated / Q000502:physiology; D017933:Peripheral Nervous System / Q000502:physiology*; D011901:Ranvier's Nodes / Q000502:physiology*; D027161:Satellite Cells, Perineuronal / Q000166:cytology / Q000502:physiology*; D012583:Schwann Cells / Q000166:cytology / Q000502:physiology*
C520294:collagen XXVIII, mouse; D003094:Collagen