Relationship between plasma carotenoids, fruit and vegetable intake, and plasma extracellular superoxide dismutase activity in women: different in health and disease?
Abstract Exogenous antioxidants may influence endogenous antioxidant enzyme activity. We observed in healthy women (n = 95) that higher plasma α-carotene, β-carotene, β-cryptoxanthin, sum of plasma carotenoids, and fruit and vegetable intake were associated with lower plasma extracellular-superoxide dismutase activity. In women with a history of cardiovascular disease, diabetes, or cancer (n = 62), we observed no associations. Our observation that plasma extracellular-superoxide dismutase activity was inversely associated with plasma carotenoids and fruit and vegetable intake in healthy women, but not in women with a history of cardiovascular disease, diabetes, or cancer, suggests that the associations between exogenous and endogenous antioxidants may differ in health and disease.
Zheng
Jinjin
J
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Rautiainen
Susanne
S
Morgenstern
Ralf
R
Wolk
Alicja
A
D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000378:metabolism; D002338:Carotenoids / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism; D004194:Disease; D005247:Feeding Behavior; D005260:Female; D005638:Fruit; D006262:Health; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood* / Q000378:metabolism; D014675:Vegetables
D000975:Antioxidants; D002338:Carotenoids; D013482:Superoxide Dismutase