Clinicopathological evaluation of duodenal well-differentiated endocrine tumors.
OBJECTIVE
To assess the clinicopathological characteristics of duodenal well-differentiated endocrine tumors.


METHODS
We examined clinicopathological characteristics in 11 consecutive patients with duodenal well-differentiated endocrine tumors treated by endoscopic therapy or surgery in our hospital from 1992 through 2007. Patients with well-differentiated endocrine tumors of the papilla of Vater or with gastrinoma were excluded.


RESULTS
Three patients received endoscopic treatment, and 8 underwent surgery. In patients who received endoscopic treatment, the tumor diameter was less than 1.0 cm, with no histopathological evidence of lymphovascular invasion or invasion of the muscularis. There were no complications such as late bleeding or perforation after treatment. Among 8 patients with tumors less than 1.0 cm in diameter, 3 underwent partial resection, and 2 underwent radical surgery. Three patients had lymphovascular invasion, 1 had invasion of the muscularis, and 1 had proximal lymph node metastasis. Among 3 patients with tumors 1.0 cm or more in diameter, 1 underwent partial resection, and 2 underwent radical surgery. One patient had lymphovascular invasion, with no lymph node metastasis. After treatment, all patients are alive and have remained free of metastasis and recurrence.


CONCLUSIONS
Duodenal well-differentiated endocrine tumors less than 1.0 cm in diameter have a risk of lymphovascular invasion, invasion of the muscularis, and lymph node metastasis, irrespective of procedural problems.
Ishido
Kenji
K
Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, Japan. k.ishido@kitasato-u.ac.jp
Tanabe
Satoshi
S
Higuchi
Katsuhiko
K
Sasaki
Tohru
T
Katada
Chikatoshi
C
Azuma
Mizutomo
M
Naruke
Akira
A
Koizumi
Wasaburo
W
Mikami
Tetsuo
T
D000328:Adult; D000368:Aged; D004379:Duodenal Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004386:Duodenum / Q000473:pathology* / Q000601:surgery; D004701:Endocrine Gland Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness