Hepatotoxicity of alpha-methyldopa in pregnancy.
Alpha-methyldopa is one of the most widely prescribed antihypertensive agents used during pregnancy. Despite its known potential hepatotoxicity, there have been only a few reports describing hepatotoxicity with the use of this drug during pregnancy. We report here a new case of acute hepatitis in a pregnant woman related to the use of alpha-methyldopa, and briefly review the literature on alpha-methyldopa-induced hepatotoxicity in pregnancy.
Slim
R
R
Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia. raoudha_slim3@yahoo.fr
Ben Salem
C
C
Hmouda
H
H
Bouraoui
K
K
D000208:Acute Disease; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy; D008750:Methyldopa / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy
D000959:Antihypertensive Agents; D008750:Methyldopa