title: Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity.
abstract: We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Breitbach
authors.forename: Adam H
authors.initials: AH
authors.lastname: Broderick
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Jewell
authors.forename: Suvai
authors.initials: S
authors.lastname: Gunasekaran
authors.forename: Qi
authors.initials: Q
authors.lastname: Lin
authors.forename: David M
authors.initials: DM
authors.lastname: Lynn
authors.forename: Helen E
authors.initials: HE
authors.lastname: Blackwell
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D048908:Aliivibrio fischeri / Q000187:drug effects*; D015394:Molecular Structure; D008970:Molecular Weight; D053038:Quorum Sensing / Q000187:drug effects*; D013499:Surface Properties
chemical_list: C088386:homoserine lactone; D015107:4-Butyrolactone