[Diabetes and hypokinetic cardiopathy : when to consider mitochondrial disease?].
The association between diabetes mellitus and hypokinetic cardiomyopathy is frequent. We report a case of diabetes and hypokinetic cardiopathy in a 40-year-old man which led to the hypothesis of maternally inherited diabetes and deafness (MIDD) due to a mitochondrial disease. This diagnosis was confirmed by genetic testing which showed a DNA A3243G mutation in the mitochondria, the prevalence of which is 1-2% in diabetes mellitus. Cardiac abnormalities are frequent (18-34% of patients depending on the series) and the co-existence of left ventricular hypertrophy and systolic dysfunction is suggestive of this disease. Some authors have proposed co-enzyme Q as a treatment to improve the left ventricular ejection fraction and insulin secretion.
Nozières
C
C
Service de cardiologie, hôpital de la Croix-Rousse, Lyon, France.
Quillasi
V
V
Mouly-Bertin
C
C
Thomson
V
V
Gachon-Lanier
E
E
Lantelme
P
P
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000235:genetics; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics; D003638:Deafness / Q000175:diagnosis / Q000235:genetics; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000235:genetics*; D003937:Diagnosis, Differential; D004452:Echocardiography; D050259:Genes, Mitochondrial / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000235:genetics; D013577:Syndrome
D004272:DNA, Mitochondrial