Location, location, location-makes all the difference for hypoxia in lung tumors.
Hypoxia is a clinically important component of the tumor microenvironment because it adversely affects progression, metastasis, response to chemoradiation therapy, and overall patient survival. Here, we describe how different animal tumor models of lung cancer can yield surprisingly different hypoxic profiles.
Maity
Amit
A
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, 19104-6072, USA. maity@uphs.upenn.edu
Koumenis
Constantinos
C
D000818:Animals; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D059016:Tumor Microenvironment