Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification.
A bombesin derivative was successfully radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Thus, (99m)Tc-HYNIC-Bombesin((7-14)) could be used as an agent for tumor diagnosis.
de Barros
André Luís Branco
AL
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
Mota
Luciene das Graças
Ld
Ferreira
Carolina de Aguiar
Cde A
Oliveira
Mônica Cristina de
MC
Góes
Alfredo Miranda de
AM
Cardoso
Valbert Nascimento
VN
D000818:Animals; D001001:Anura; D001839:Bombesin / Q000031:analogs & derivatives* / Q000737:chemistry; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging / Q000378:metabolism; D007202:Indicators and Reagents; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D021241:Spectrometry, Mass, Electrospray Ionization; D013667:Technetium; D014018:Tissue Distribution
D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; C555232:technetium 99m HYNIC-bombesin (7-14); D013667:Technetium; D001839:Bombesin