title: Chloral hydrate to study auditory brainstem response.
abstract: Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems.
  
  
  OBJECTIVE
  To assess the efficacy of the drug in performing ABR and to systematize its use.
  
  
  METHODS
  A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50 mg/Kg, with a boost dose of 6 mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50 mg or 56 mg/Kg), age, weight and gender.
  
  
  RESULTS
  All the 41 children who participated in the study took 50 mg/kg of the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6 mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose.
  
  
  CONCLUSIONS
  CH produced a satisfactory effect with 50 mg/Kg dose plus 6 mg/kg up to one hour after administration. Complications can occur regardless of the dose used.
authors.affiliation: Otorhinolaryngology Department - FMUSP, ENT - DERDIC/PUCSP. lopessquare@ig.com.br
authors.forename: Mariana Lopes
authors.initials: ML
authors.lastname: Fávero
authors.forename: Fabiana Amaral Sanches
authors.initials: FA
authors.lastname: Ponce
authors.forename: Marcio Ricardo Barros
authors.initials: MR
authors.lastname: Pio
authors.forename: Alfredo
authors.initials: A
authors.lastname: Tabith Junior
authors.forename: Fernando Leite
authors.initials: FL
authors.lastname: Carvalho e Silva
mesh_terms: D002648:Child; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000008:administration & dosage* / Q000009:adverse effects; D003430:Cross-Sectional Studies; D054810:Deep Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D008297:Male; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate