title: Malignant insulinoma in a child.
abstract: Insulinomas are rare tumors with an estimated incidence of one per 250,000 person-years. Most insulinomas are benign with less than 10% demonstrating malignant behavior, the vast majority of which occur in adults. A systemic review of the literature revealed only nine cases of malignant insulinomas occurring in children. Herein, we present a case of metastatic malignant insulinoma in a 12-year-old child. The occurrence of this diagnosis in a child, its unusual pattern of metastases and the challenging management of severe hypoglycemia make this case worth reporting.
authors.affiliation: Department of Pediatric Oncology, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Waleed
authors.initials: W
authors.lastname: Janem
authors.forename: Iyad
authors.initials: I
authors.lastname: Sultan
authors.forename: Fatena
authors.initials: F
authors.lastname: Ajlouni
authors.forename: Rasha
authors.initials: R
authors.lastname: Deebajeh
authors.forename: Hussam
authors.initials: H
authors.lastname: Haddad
authors.forename: Maher A
authors.initials: MA
authors.lastname: Sughayer
authors.forename: Rula Y
authors.initials: RY
authors.lastname: Goussous
mesh_terms: D002648:Child; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis* / Q000556:secondary; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology