G-CSF and CD34+ progenitor cells in hematopoietic grafts: too fertile for human cytomegalovirus.
Smith et al. (2010) establish a humanized mouse model of latent host and cellular tropism of human cytomegalovirus (HCMV) infection and examine the effects of granulocyte-colony stimulating factor (GCSF) on human cytomegalovirus (HCMV) reactivation in vivo. HCMV-infected circulating CD34(+) myeloid cells populate end organs such as the liver and differentiate into cells capable of supporting lytic infection.
Shimamura
Masako
M
Department of Pediatrics, University of Alabama School of Medicine, Children's Hospital, 1600 7th Avenue South, Birmingham, AL 35233, USA.
Britt
William J
WJ