title: Evaluation of antibacterial soap in the management of lymphoedema in Leogane, Haiti.
abstract: In areas endemic for lymphatic filariasis, progression of lymphoedema is associated with recurrent bacterial acute dermatolymphangioadenitis (ADLA). The role of antibacterial soap in preventing ADLA is unknown. In a randomized double-blinded clinical trial in Leogane, Haiti, lymphoedema patients washed affected legs with antibacterial (n = 97) or plain soap (n = 100). Reported ADLA incidence (by recall) before the study was 1.1 episodes per person-year, compared to 0.40 assessed during the 12-month study. ADLA incidence was significantly associated with age, illiteracy and lymphoedema stage, but not with soap type. Washing with soap, regardless of its antibacterial content, can help decrease ADLA incidence. (ClinicalTrials.gov identifier number NCT00139100.).
authors.affiliation: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dgaddiss@yahoo.com
authors.forename: David G
authors.initials: DG
authors.lastname: Addiss
authors.forename: Marie-Carmel
authors.initials: MC
authors.lastname: Michel
authors.forename: Antoine
authors.initials: A
authors.lastname: Michelus
authors.forename: Jeanne
authors.initials: J
authors.lastname: Radday
authors.forename: Ward
authors.initials: W
authors.lastname: Billhimer
authors.forename: Jacky
authors.initials: J
authors.lastname: Louis-Charles
authors.forename: Jacquelin M
authors.initials: JM
authors.lastname: Roberts
authors.forename: Kathy
authors.initials: K
authors.lastname: Kramp
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Dahl
authors.forename: Bruce
authors.initials: B
authors.lastname: Keswick
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004605:Elephantiasis, Filarial / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D008209:Lymphedema / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D012915:Soaps / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D012915:Soaps