[Pandemic influenza A/H1N1v, pregnancy and vaccination].
Seasonal flu is potentially more severe during pregnancy especially when it occurs in the last three months. Pregnant women were shown to be especially exposed to severe forms of the flu and death in the first weeks of the pandemic influenza A/H1N1v. For the first time in history, adequate vaccines were available in the early phase of the pandemic and recommended by WHO as a priority for pregnant women. In France, vaccination with the non-adjuvanted vaccine (Panenza®) was recommended after three months of pregnancy. However, the pandemic vaccines were discredited by the mass media and the population even before they were available. This was due to several factors, and especially to the lack of information on the vaccine and its potential toxicity and, in case of pregnancy, potential risk of adverse fetal events, despite the fact that available data shows the seasonal flu vaccine is effective and well tolerated in pregnant women. This article aimed to provide decisional elements for influenza A/H1N1v vaccination in pregnant women.
Bulifon
S
S
Inserm, Centre d'Investigation-Clinique Cochin Pasteur (CIC BT505), Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, 75014 Paris, France.
Tsatsaris
V
V
Goffinet
F
F
Mignon
A
A
Batteux
F
F
Delfraissy
J-F
JF
Launay
O
O
D000328:Adult; D002648:Child; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000821:virology; D005602:France / Q000453:epidemiology; D006266:Health Education; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D008402:Mass Media; D008875:Middle Aged; D058873:Pandemics; D010920:Placenta / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D011639:Public Opinion; D012306:Risk; D012621:Seasons; D014611:Vaccination / Q000009:adverse effects / Q000523:psychology / Q000706:statistics & numerical data
D007252:Influenza Vaccines