title: The clinical implication and prediction of diffuse splenic FDG uptake during cancer surveillance.
abstract: OBJECTIVE
  The purpose of this study was to investigate correlations between diffuse splenic FDG uptake and hematological and inflammatory parameters to clarify the significance of splenic FDG uptake on PET/CT images.
  
  
  METHODS
  We retrospectively analyzed the consecutive records of F-18 FDG PET/CT scans and selected 31 patients with diffuse splenic FDG uptake as patient group. A total of 25 patients who underwent F-18 FDG PET/CT scans for simple health checkup were enrolled as control group. ROIs were placed on the liver and spleen to measure maximal standardized uptake value (SUVmax). The spleen SUVmax was divided by the liver SUVmax to calculate the spleen/liver ratio. The correlations between the S/L ratio and various hematological parameters were evaluated.
  
  
  RESULTS
  The S/L ratio was positively correlated with serum C-reactive protein level, white blood cell count, and neutrophil count and negatively correlated with hemoglobin, hematocrit, and red blood cell count. Under multiple regression analysis, the Hb level and the C-reactive protein level were the significant predictors for diffuse splenic FDG uptake.
  
  
  CONCLUSIONS
  In conclusion, our study suggests that concurrent inflammation or anemia at the time of PET/CT study could be one of various causes of diffuse splenic FDG uptake.
authors.affiliation: Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Hyun-Yeol
authors.initials: HY
authors.lastname: Nam
authors.forename: Seong-Jang
authors.initials: SJ
authors.lastname: Kim
authors.forename: In-Joo
authors.initials: IJ
authors.lastname: Kim
authors.forename: Bum-Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Kyoungjune
authors.initials: K
authors.lastname: Pak
authors.forename: Keunyoung
authors.initials: K
authors.lastname: Kim
mesh_terms: D001692:Biological Transport; D001853:Bone Marrow / Q000378:metabolism; D004058:Diffusion; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism*; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D013154:Spleen / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18