Streptococcus pneumoniae nasopharyngeal colonization in children in Brasov, Central Romania: high antibiotic resistance and coverage by conjugate vaccines.
We report high colonization rates among 400 healthy infants and children, and moderate (66%) coverage by PCV7 and PCV10, with a superior (80%) PCV13 coverage. Most frequent serotypes were 23F, 6B, 19F, and 14. Resistance to penicillin, ceftriaxone, erythromycin, and trimethoprim/sulfamethoxazole was 83%, 18%, 62%, and 66%, respectively. 67% isolates were multidrug resistant. Pneumococcal conjugate vaccines covered 80% to 93% of multidrug resistant isolates.
Falup-Pecurariu
Oana
O
Department of Pediatrics, Children's Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania.
Bleotu
Laura
L
Zavarache
Cristina
C
Peled
Nechama
N
Anton
Oana
O
Robu
Michaela
M
Falup-Pecurariu
Cristian
C
Rogozea
Liliana
L
Porat
Nurith
N
Greenberg
David
D
Dagan
Ron
R
Leibovitz
Eugene
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D012383:Romania / Q000453:epidemiology; D012703:Serotyping; D022541:Streptococcal Vaccines / Q000008:administration & dosage*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification*; D018074:Vaccines, Conjugate / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D022541:Streptococcal Vaccines; D018074:Vaccines, Conjugate