title: DNA hybridization induced selective encapsulation of small dye molecules in dendrimer based microcapsules.
abstract: A novel approach for selectively encapsulating Cy5 dye molecules via DNA hybridization in cationic phosphorus dendrimers (G(4)(+))/polystyrenesulfonate (PSS) microcapsules has been developed. The hybridization between Cy5 labeled single strand DNA (ssDNA) targets and complementary ssDNA probes was performed in the microcapsules. During hybridization, the ssDNA targets acted as 'vehicles' and Cy5 dye molecules as 'cargos', which led to the selective encapsulation of the Cy5 molecules inside the capsules. The approach may be applied for many small molecules, which are usually difficult to be encapsulated due to their diffusion properties in microcapsules.
authors.affiliation: State Key Lab of Metal matrix Composites, School of Materials Science & Engineering, Shanghai Jiao Tong University, 800 DongChuan Road, Shanghai, 200240, China. clfeng@sjtu.edu.cn
authors.forename: Chuan-Liang
authors.initials: CL
authors.lastname: Feng
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Caminade
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Majoral
authors.forename: Jiajun
authors.initials: J
authors.lastname: Gu
authors.forename: Shenmin
authors.initials: S
authors.lastname: Zhu
authors.forename: Huilan
authors.initials: H
authors.lastname: Su
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Hu
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
mesh_terms: D002214:Capsules / Q000737:chemistry; D002232:Carbocyanines / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D010758:Phosphorus / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry
chemical_list: D002214:Capsules; D002232:Carbocyanines; D004277:DNA, Single-Stranded; D050091:Dendrimers; D005456:Fluorescent Dyes; D011137:Polystyrenes; C085321:cyanine dye 5; D010758:Phosphorus; C003321:polystyrene sulfonic acid