title: Trends in the incidence of basal cell carcinoma by histopathological subtype.
abstract: BACKGROUND
  As a result of the high prevalence, basal cell carcinoma (BCC) causes a significant and expensive health care problem.
  
  
  OBJECTIVE
  In this study, we evaluate the proportional increase in BCC by histological subtype over the last two decades.
  
  
  METHODS
  We retrospectively reviewed all primary histological confirmed BCCs diagnosed in the Maastricht University Medical Centre in The Netherlands in the years 1991, 1999 and 2007.
  
  
  RESULTS
  An annual increase of the number of BCCs of 7% for both genders was shown. The age-standardized incidence rates for BCC increased between 1991 and 2007 from 54.2 to 162.1 per 100, 000 men and from 61.7 to 189.8 per 100, 000 women. The proportion of superficial BCC increased significantly from 17.6% to 30.7%.
  
  
  CONCLUSIONS
  The incidence of BCC is continuing to increase this century. The observed shift to the superficial histological subtype, which can be treated non-surgically, might reduce the workload in the busy dermatologists practice.
authors.affiliation: Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands. a.arits@mumc.nl
authors.forename: A H M M
authors.initials: AH
authors.lastname: Arits
authors.forename: M H J
authors.initials: MH
authors.lastname: Schlangen
authors.forename: P J
authors.initials: PJ
authors.lastname: Nelemans
authors.forename: N W J
authors.initials: NW
authors.lastname: Kelleners-Smeets
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology