Experimental model of isolated lung perfusion in rats: technique and application in lung preservation studies.
Small animal models are particularly suitable for lung preservation studies, because they are simple and cost-effective. This brief communication focuses on the technical description of an ex vivo lung perfusion model in rats by means of a commercially available apparatus, which was the first to be installed in a thoracic surgery research laboratory in Brazil. The model and its preparation, together with its applications for lung preservation studies, are described in detail. All technical details can also be seen in a video posted on the website of the Brazilian Journal of Pulmonology.
Pêgo-Fernandes
Paulo Manuel
PM
Departamento de Cardiopneumologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil. paulopego@incor.usp.br
Werebe
Eduardo de Campos
Ede C
Cardoso
Paulo Francisco Guerreiro
PF
Pazetti
Rogério
R
Oliveira
Karina Andrighetti de
KA
Soares
Paula Roberta Otaviano
PR
Jatene
Fabio Biscegli
FB
D000818:Animals; D008168:Lung; D016040:Lung Transplantation; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*; D011897:Random Allocation; D051381:Rats