Heterogeneity in the muscle satellite cell population.
Satellite cells, the adult stem cells responsible for skeletal muscle regeneration, are defined by their location between the basal lamina and the fiber sarcolemma. Increasing evidence suggests that satellite cells represent a heterogeneous population of cells with distinct embryological origin and multiple levels of biochemical and functional diversity. This review focuses on the rich diversity of the satellite cell population based on studies across species. Ultimately, a more complete characterization of the heterogeneity of satellite cells will be essential to understand the functional significance in terms of muscle growth, homeostasis, tissue repair, and aging.
Biressi
Stefano
S
Department of Neurology and Neurological Sciences, Stanford University, School of Medicine, Stanford, CA 94305-5235, USA.
Rando
Thomas A
TA
D000818:Animals; D019070:Cell Lineage; D049109:Cell Proliferation; D006801:Humans; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology* / Q000502:physiology*