title: Dosimetric comparison of 6 MV and 15 MV single arc rapidarc to helical TomoTherapy for the treatment of pancreatic cancer.
abstract: We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with 6-MV beam (Plan_(HT6)), one using single-arc RA with 6-MV beam (Plan_(RA6)), and one using single-arc RA with 15-MV beam (Plan_(RA15)). Dosimetric indices including high/low conformality index (CI(100%)/CI(50%)), heterogeneity index (HI), monitor units (MUs), and doses to organs at risk (OARs) were compared. The mean CI(100%) was statistically equivalent with respect to the 2 treatment techniques, as well as beam energy (0.99, 1.01, and 1.02 for Plan_(HT6), Plan_(RA6), and Plan_(RA156,) respectively). The CI(50%) and HI were improved in both RA plans over the HT plan. The RA plans significantly reduced MU (MU(RA6) = 697, MU(RA15) = 548) compared with HT (MU(HT6) = 6177, p = 0.008 in both cases). The mean maximum cord dose was decreased from 29.6 Gy in Plan_(HT6) to 21.6 Gy (p = 0.05) in Plan_(RA6) and 21.7 Gy (p = 0.04) in Plan_(RA15). The mean bowel dose decreased from 17.2 Gy in Plan_(HT6) to 15.2 Gy (p = 0.03) in Plan_(RA6) and 15.0 Gy (p = 0.03) Plan_(RA15). The mean liver dose decreased from 8.4 Gy in Plan_(HT6) to 6.3 Gy (p = 0.04) in Plan_(RA6) and 6.2 Gy in Plan_(RA15). Variations of the mean dose to the duodenum, kidneys, and stomach were statistically insignificant. RA and HT can both deliver conformal dose distributions to target volumes while limiting the dose to surrounding OARs in the treatment of pancreatic cancer. Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. jing.cai@duke.edu
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.forename: Jinbo
authors.initials: J
authors.lastname: Yue
authors.forename: Robert
authors.initials: R
authors.lastname: McLawhorn
authors.forename: Wensha
authors.initials: W
authors.lastname: Yang
authors.forename: Krishni
authors.initials: K
authors.lastname: Wijesooriya
authors.forename: Neal E
authors.initials: NE
authors.lastname: Dunlap
authors.forename: Ke
authors.initials: K
authors.lastname: Sheng
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yin
authors.forename: Stanley H
authors.initials: SH
authors.lastname: Benedict
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D036542:Tomography, Spiral Computed / Q000379:methods*