Experimental atherosclerosis in rabbits.
Many researches have been conducted in experimental models in order to study the development of atherosclerosis from hyperlipidemia-inducing diets. Since rabbits are very sensitive to cholesterol-rich diets and accumulate large amounts of cholesterol in their plasma, their use as experimental models to evaluate the development of atherosclerosis is highly relevant and brings information on factors that contribute to the progression and regression of this condition that can be applied to humans. As such, this review includes studies on the atherogenic function of cholesterol based on rabbits as the experimental model, since they have become the most largely used experimental model of atherosclerosis.
Dornas
Waleska C
WC
Universidade Federal de Ouro Preto, Belo Horizonte, MG.
Oliveira
Tânia T de
TT
Augusto
Luis E Franklin
LE
Nagem
Tanus J
TJ
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D003331:Coronary Vessels / Q000473:pathology; D004032:Diet; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D006937:Hypercholesterolemia / Q000150:complications* / Q000378:metabolism; D011817:Rabbits
D002791:Cholesterol, Dietary; D002784:Cholesterol