title: Na/K ATPase activity is coordinated with the persistent sodium current amplitude.
abstract: It is known that the Na+/K+ ATPase may control the frequency of slow action potential bursts that can be found in motor patterns generating neurons. Thus, Na+/K+ ATPase can participate in the formation of firing patterns in neurons and it is likely that the ATPase activity is coordinated with the expression of ionic channels. However, so far, there is no such evidence. Here it is shown that, in pyramidal neurons of the rat prefrontal cortex, the density of electrogenic sodium-potassium ATPase current was correlated with the density of the persistent sodium current (R2=0.62, P<0.002). It is speculated that such coordination may improve the control of the firing patterns in prefrontal cortex pyramidal neurons.
authors.affiliation: Psychiatric Institute, University of Illinois, West Taylor Street, Chicago, Illinois, USA. baranauskas.gytis@iit.it
authors.forename: Gytis
authors.initials: G
authors.lastname: Baranauskas
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D008564:Membrane Potentials / Q000502:physiology; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques / Q000379:methods; D017397:Prefrontal Cortex / Q000166:cytology / Q000201:enzymology*; D017966:Pyramidal Cells / Q000201:enzymology*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D026941:Sodium Channel Blockers / Q000494:pharmacology; D015222:Sodium Channels / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D026941:Sodium Channel Blockers; D015222:Sodium Channels; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase