Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating.
Stress is a key determinant of binge eating (BE). Since Rhodiola rosea is known to modulate stress responses, its effect in a model of BE was investigated. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/re-feeding (for 4days 66% of the usual chow intake; for 4days food ad libitum) and acute stress on the test day (day 25). R. rosea dry extract (3% rosavin, 3.12% salidroside) or its active principles were given by gavage 1h before access to HPF. Only rats exposed to both food restrictions and stress exhibited BE in the first 15-60min after the stressful procedure. R. rosea extract 10mg/kg significantly reduced and 20mg/kg abolished the BE episode. R. rosea extract 20mg/kg abolished also stress-induced increase in serum corticosterone levels. The R. rosea active principle salidroside, but not rosavin, at doses present in the extract, dose-dependently reduced or abolished BE for the period in which it was elicited. In conclusion results indicate that R. rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect.
Cifani
Carlo
C
School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino (MC), Italy. carlo.cifani@unicam.it
Micioni Di Bonaventura
Maria Vittoria
MV
Vitale
Giovanni
G
Ruggieri
Valentina
V
Ciccocioppo
Roberto
R
Massi
Maurizio
M
D000704:Analysis of Variance; D000818:Animals; D002032:Bulimia / Q000188:drug therapy*; D004195:Disease Models, Animal; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola; D013315:Stress, Psychological / Q000188:drug therapy
D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; C009172:rhodioloside