title: Case report: Treatment failure using propanolol for treatment of focal subglottic hemangioma.
abstract: Subglottic hemangioma is a rare, potentially life threatening tumor of infancy which poses serious treatment challenges. A number of medical and surgical therapies over the years have met with variable success, and are associated with numerous potential morbidities. A potential windfall in the management of infantile hemangiomas has arisen with the recent identification of propanolol as a highly efficacious and relatively safe new treatment modality. At least five reports in the literature have described the rapid, successful treatment of airway hemangiomas with oral propanolol. We describe the first reported treatment failure with propanolol for subglottic hemangioma in an infant who initially responded dramatically to the medication.
authors.affiliation: Department of Otolaryngology Head & Neck Surgery, Yale University School of Medicine, United States.
authors.forename: Karina T
authors.initials: KT
authors.lastname: Canadas
authors.forename: Eric D
authors.initials: ED
authors.lastname: Baum
authors.forename: Stella
authors.initials: S
authors.lastname: Lee
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Ostrower
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology; D006391:Hemangioma / Q000151:congenital / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000151:congenital / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D007828:Laryngoscopy / Q000379:methods; D007829:Laryngostenosis / Q000175:diagnosis / Q000209:etiology; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011433:Propranolol / Q000008:administration & dosage*; D019233:Retreatment; D018570:Risk Assessment; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D011433:Propranolol