Is elevated SUA associated with a worse outcome in young Chinese patients with acute cerebral ischemic stroke?
BACKGROUND
Elevated serum uric acid (SUA) levels can enhance its antioxidant prosperities and reduce the occurrence of cerebral infarction. Significantly elevated SUA levels have been associated with a better prognosis in patients with cerebral infarction; however, the results from some studies on the relationship between SUA and the prognosis of patients with cerebral infarction remain controversial.


METHODS
We analyzed the relationship between SUA and clinical prognosis of 585 young Chinese adults with acute ischemic stroke as determined by the modified Rankin Scale at discharge. Using multivariate logistic regression modeling, we explore the relationship between SUA levels and patient's clinical prognosis.


RESULTS
Lower SUA levels at time of admission were observed more frequently in the lowest quintile for patients with severe stroke (P = 0.02). Patients with cerebral infarction patients caused by small-vessel blockage had higher SUA concentrations (P = 0.01) and the lower mRS scores (P < 0.01) were observed in, while the lowest SUA concentrations and the highest mRS scores were seen in patients with cardiogenic cerebral infarction patients. Logistic regression analysis adjusted for confounders confirmed the following independent predictors for young cerebral infarction: uric acid (-0.003: 95%CI 0.994 to 0.999) and platelet (0.004, 95%CI 0.993 to 0.996).


CONCLUSIONS
Elevated SUA is an independent predictor for good clinical outcome of acute cerebral infarction among young adults.
Zhang
Bin
B
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang east Road, GuangZhou, 510260 Guangdong Province, China.
Gao
Cong
C
Yang
Ning
N
Zhang
WeiZhi
W
Song
XingWang
X
Yin
JianRui
J
Pu
ShuXiang
S
Yi
YongHong
Y
Gao
QingChun
Q
D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid