Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.
Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.
Nogawa
Toshihiko
T
Chemical Biology Department, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Okano
Akiko
A
Takahashi
Shunji
S
Uramoto
Masakazu
M
Konno
Hideaki
H
Saito
Tamio
T
Osada
Hiroyuki
H
D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
D007769:Lactams; D018942:Macrolides; C555151:verticilactam