Candidate genes and potential targets for therapeutics in Wilms' tumour.
Wilms' tumour (WT) is the most common malignant renal tumour of childhood. During the past two decades or so, molecular studies carried out on biopsy specimens and tumour-derived cell lines have identified a multitude of chromosomal and epigenetic alterations in WT. In addition, a significant amount of evidence has been gathered to identify the genes and signalling pathways that play a defining role in its genesis, growth, survival and treatment responsiveness. As such, these molecules and mechanisms constitute potential targets for novel therapeutic strategies for refractory WT. In this report we aim to review some of the many candidate genes and intersecting pathways that underlie the complexities of WT biology.
Blackmore
Christopher
C
Southern Alberta Children's Cancer Program, Alberta Children's Hospital, Calgary, Alberta, Canada.
Coppes
Max J
MJ
Narendran
Aru
A
D002869:Chromosome Aberrations; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D056426:Genetic Loci; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D009396:Wilms Tumor / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology