title: Designer nanorings with functional cavities from self-assembling β-sheet peptides.
abstract: β-Barrel proteins that take the shape of a ring are common in many types of water-soluble enzymes and water-insoluble transmembrane pore-forming proteins. Since β-barrel proteins perform diverse functions in the cell, it would be a great step towards developing artificial proteins if we can control the polarity of artificial β-barrel proteins at will. Here, we describe a rational approach to construct β-barrel protein mimics from the self-assembly of peptide-based building blocks. With this approach, the direction of the self-assembly process toward the formation of water-soluble β-barrel nanorings or water-insoluble transmembrane β-barrel pores could be controlled by the simple but versatile molecular manipulation of supramolecular building blocks. This study not only delineates the basic driving force that underlies the folding of β-barrel proteins, but also lays the foundation for the facile fabrication of β-barrel protein mimics, which can be developed as nanoreactors, ion- and small-molecule-selective pores, and novel antibiotics.
authors.affiliation: Center for Supramolecular Nano-Assembly and Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
authors.forename: Il-Soo
authors.initials: IS
authors.lastname: Park
authors.forename: You-Rim
authors.initials: YR
authors.lastname: Yoon
authors.forename: Minseon
authors.initials: M
authors.lastname: Jung
authors.forename: Kimoon
authors.initials: K
authors.lastname: Kim
authors.forename: SeongByeong
authors.initials: S
authors.lastname: Park
authors.forename: Seokmin
authors.initials: S
authors.lastname: Shin
authors.forename: Yong-beom
authors.initials: YB
authors.lastname: Lim
authors.forename: Myongsoo
authors.initials: M
authors.lastname: Lee
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary
chemical_list: D008051:Lipid Bilayers; D010455:Peptides