title: Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease.
abstract: Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder of the aging population characterized by α-synuclein accumulation in cortical and subcortical regions. Although neuropathology in advanced age has been investigated in dementias such as Alzheimer Disease (AD), severity of the neuropathology in the oldest old with DLB remains uncharacterized. For this purpose we compared characteristics of DLB cases divided into three age groups 70-79, 80-89 and ≥ 90 years (oldest old). Neuropathological indicators and levels of synaptophysin were assessed and correlated with clinical measurements of cognition and dementia severity. These studies showed that frequency and severity of DLB was lower in 80-89 and ≥ 90 year cases compared to 70-79 year old group but cognitive impairment did not vary with age. The extent of AD neuropathology correlated with dementia severity only in the 70-79 year group, while synaptophysin immunoreactivity more strongly associated with dementia severity in the older age group in both DLB and AD. Taken together these results suggest that the oldest old with DLB might represent a distinct group.
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, USA.
authors.forename: Kiren
authors.initials: K
authors.lastname: Ubhi
authors.forename: Kevin
authors.initials: K
authors.lastname: Peng
authors.forename: Stephanie
authors.initials: S
authors.lastname: Lessig
authors.forename: Jennilyn
authors.initials: J
authors.lastname: Estrella
authors.forename: Anthony
authors.initials: A
authors.lastname: Adame
authors.forename: Douglas
authors.initials: D
authors.lastname: Galasko
authors.forename: David P
authors.initials: DP
authors.lastname: Salmon
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Hansen
authors.forename: Claudia H
authors.initials: CH
authors.lastname: Kawas
authors.forename: Eliezer
authors.initials: E
authors.lastname: Masliah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020961:Lewy Body Disease / Q000473:pathology* / Q000523:psychology; D008297:Male; D016501:Neurites / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000473:pathology; D009483:Neuropsychological Tests; D016612:Paraffin Embedding; D058225:Plaque, Amyloid / Q000473:pathology; D017729:Presynaptic Terminals / Q000378:metabolism / Q000473:pathology; D016708:Synaptophysin / Q000378:metabolism; D016707:Tissue Fixation; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D016708:Synaptophysin; D051844:alpha-Synuclein