Impact of residual renal function and HCV seropositivity on plasma CD40/CD40L system and oxidative status in haemodialysis patients.
OBJECTIVE
We evaluated the impact of residual renal function (RRF) on oxidative stress (SOX) and CD40/CD40L system in haemodialysis (HD) patients.


METHODS
We determined sCD40, sCD40L and SOX marker-Cu/Zn superoxide dismutase (Cu/Zn SOD) levels in HD patients with RRF, with anuria (A) and in healthy controls.


RESULTS
sCD40 and Cu/Zn SOD plasma levels were higher in both groups of dialyzed patients compared to controls (all p<0.001), and they were higher in A than in RRF patients (all p<0.01). In RRF group, sCD40/sCD40L and Cu/Zn SOD were significantly higher in anti-HCV-seropositive (anti-HCV[+]) patients than in their anti-HCV[-] counterparts. This phenomenon was not observed in A group. Multiple regression analysis showed that Cu/Zn SOD, kt/V and low fibrinogen were the independent factors affecting sCD40 levels in the whole HD group.


CONCLUSIONS
The loss of RRF and HCV seropositivity increased plasma levels of sCD40/sCD40L and oxidative status in HD patients.
Pawlak
Krystyna
K
Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland. krystynapawlak@poczta.onet.pl
Mysliwiec
Michal
M
Pawlak
Dariusz
D
D000328:Adult; D000368:Aged; D019013:CD40 Antigens / Q000097:blood*; D023201:CD40 Ligand / Q000097:blood*; D005260:Female; D016174:Hepacivirus / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy / Q000821:virology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D006435:Renal Dialysis; D013482:Superoxide Dismutase / Q000097:blood
D019013:CD40 Antigens; D023201:CD40 Ligand; D013482:Superoxide Dismutase