Prognostic potential of detection of WT1 mRNA level in peripheral blood in adult acute myeloid leukemia.
We retrospectively analyzed the potential of Wilms' tumor gene 1 (WT1) mRNA levels in peripheral blood for predicting the prognosis of 50 patients with AML. After achieving complete remission (CR), 34 patients (69.4%) were determined to be positive and 15 (30.6%) were negative for WT1. The relapse rate of the positive and negative patients was 73.5% and 40.0% (p&#x2009;=&#x2009;0.02), respectively. After consolidation therapy, only 15 patients (32.6%) were positive and 31 (67.4%) were negative for WT1. Although the relapse rate of the positive and negative patients was 80.0% and 54.8% (p&#x2009;=&#x2009;0.10), respectively, the rate of relapse within 1 year was 73.3% in positive patients and only 33.3% in negative patients (p&#x2009;=&#x2009;0.01), respectively. The disease-free survival (DFS) rate at 3 years was 20.0% for positive patients and 50.0% for negative patients (p&#x2009;=&#x2009;0.01). The overall survival (OS) rate at 3 years was 42.8% in positive patients and 69.8% in negative patients (p&#x2009;=&#x2009;0.04), respectively. WT1 mRNA levels in the peripheral blood can predict relapse after CR, and its levels after consolidation therapy are closely correlated with DFS, OS, and early relapse.
Miyawaki
Shuichi
S
Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan. miyawaki@mail.wind.ne.jp
Hatsumi
Nahoko
N
Tamaki
Toshiharu
T
Naoe
Tomoki
T
Ozawa
Keiya
K
Kitamura
Kunio
K
Karasuno
Takahiro
T
Mitani
Kinuko
K
Kodera
Yoshihisa
Y
Yamagami
Tamotsu
T
Koga
Daisuke
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000097:blood*; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D025721:WT1 Proteins / Q000235:genetics*; D055815:Young Adult
D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D025721:WT1 Proteins