Establishment of a porcine model for lobar lung auto-transplantation.
OBJECTIVE
The aim of this study was to develop a porcine model of left single lung auto-transplantation.


METHODS
Eighteen 50-kg male domestic pigs underwent left pneumonectomy and lobar lung auto-transplantation (left lower lobe). Each animal was allocated to a perfusion protocol during surgery: group I, cold saline (n = 6); group II, cold heparin (n = 6); and group III, cold Euro-Collins (n = 6). We measured changes of partial pressure of oxygen in pulmonary vein blood (PvO(2)), partial pressure of carbon dioxide in pulmonary vein blood (PvCO(2)), lung compliance, and mean pulmonary artery pressure.


RESULTS
The postoperative survival rate was 100%. PvO(2), PvCO(2), mean pulmonary artery pressure, and lung compliance of the left lower lobe showed a significant difference between the saline and the heparin groups or the Euro-Collins group (P < .05), whereas there was no significant difference between the heparin and the Euro-Collins groups.


CONCLUSIONS
Compared with other species, humans and pigs show remarkable anatomical and physiological similarity. It is useful experimental animal model to evaluate pulmonary function and grafting protocols following lobar lung transplantation.
Ren
B
B
Department of Thoracic Surgery, Cancer Institute and Hospital of Jiangsu Province, Nanjing, China.
Li
M
M
Hu
Z
Z
Hu
J
J
Jiang
F
F
Ying
R
R
Zhang
Z
Z
Xu
L
L
D000714:Anastomosis, Surgical; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D002648:Child; D006801:Humans; D008170:Lung Compliance / Q000502:physiology; D016040:Lung Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D023421:Models, Animal; D011013:Pneumonectomy; D011651:Pulmonary Artery / Q000502:physiology / Q000503:physiopathology; D015424:Reperfusion; D015996:Survival Rate; D013552:Swine; D013997:Time Factors; D014182:Transplantation, Autologous / Q000379:methods*