Direct observation of key intermediates by negative-ion electrospray ionisation mass spectrometry in palladium-catalysed cross-coupling.
Negative-ion electrospray ionisation mass spectrometry with an anionic phosphine ligand enables detection of key intermediates in the Sonogashira reaction. MS/MS techniques are used to generate a Hammett plot for the key reductive elimination step.
Vikse
Krista L
KL
Department of Chemistry, University of Victoria, P.O. Box 3065, Victoria, BC V8W3V6, Canada.
Henderson
Matthew A
MA
Oliver
Allen G
AG
McIndoe
J Scott
JS