[The detection and clinical significance of hepatic fibrosis index].
OBJECTIVE
To study the relationship between levels of serum HA, LN, IV-C, PC III of chronic hepatitis and indexes of hepatic fibrosis.


METHODS
The levels of serum HA, LN, IV-C and PC III of chronic hepatitis of 124 cases and health 18 cases were measured by radio immunoassay, combined with clinical characteristics and 33 cases pathologic slice etc. The diagnostic of the indexes of serum was analyzed with statistics.


RESULTS
HA and IV-C are parallel in chronic hepatitis periods. LN and PC III are concert in the same pathologic periods. In G4 period PC III is nearly closed with comparative group. The value of HA, LN, NV-C and PC III in the chronic hepatitis group was significantly higher than that in the normal comparative group. Conclusion The levels of serum HA LN IV-C and PC III are in concert with the degree of hepatic fibrosis, and these indexes are valuable for chronic hepatitis diagnoses combined with the clinic. LN and PC III are coincidence with hepatic fibrosis degree before G4 period.
Xu
Chun-Hai
CH
The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Meng
Dong-Mei
DM
Lv
Shu-Lan
SL
Kang
Peng
P
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003094:Collagen / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011347:Procollagen / Q000097:blood
D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D007797:Laminin; D011347:Procollagen; D006820:Hyaluronic Acid; D003094:Collagen