title: Development of selective inhibitors of necrosis.
abstract: Oxidative stress-induced necrosis plays an important role in ischemia-reperfusion injury, such as stroke and heart attack. Here, we describe the development of selective inhibitors of necrosis, MS-1 and IM-54, as potential cardioprotective agents and biological tools for investigating the molecular mechanisms of cell death. By means of chemical modifications of kinase inhibitor BM I, its affinity for various kinases was successfully removed and a potent and selective inhibitor of necrosis, IM-54, was obtained. IM-54 inhibits necrosis induced by oxidative stress, but not apoptosis induced by anticancer drugs.
authors.affiliation: RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. sodeoka@riken.jp
authors.forename: Mikiko
authors.initials: M
authors.lastname: Sodeoka
authors.forename: Kosuke
authors.initials: K
authors.lastname: Dodo
mesh_terms: D002316:Cardiotonic Agents / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000627:therapeutic use; D008301:Maleimides / Q000737:chemistry* / Q000627:therapeutic use; D009336:Necrosis / Q000378:metabolism*; D018384:Oxidative Stress; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D011758:Pyrroles / Q000737:chemistry; D015427:Reperfusion Injury / Q000188:drug therapy / Q000473:pathology
chemical_list: C527045:2-(1-(3-aminopropyl)indol-3-yl)-3-(indol-3-yl)-N-methylmaleimide; C503757:2-(1H-indol-3-yl)-3-pentylamino-maleimide; D002316:Cardiotonic Agents; D007211:Indoles; D008301:Maleimides; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D011493:Protein Kinase C