Morphological changes in porcine bioprosthetic valves of a HeartMate left ventricular assist device.
A 27-year-old man who received a HeartMate (Thoratec Corporation, USA) left ventricular assist device for progressive heart failure as a bridge to orthotopic heart transplantation is described in the present report. The device failed (mechanical failure) after almost 19 months. The porcine bioprosthetic valves in the inflow and outflow cannulae showed hemorrhage, cusp tears and inflammatory cells, located largely on the inflow valve cusps. The role of the inflammatory cell reaction in the bioprosthetic valve is discussed.
Khan
Nasir A
NA
Department of Pathology, Toronto General Hospital, University of Toronto, Ontario.
Butany
Jagdish
J
Zhou
Taylor
T
Leong
Shaun
S
Rao
Vivek
V
Ross
Heather
H
D000328:Adult; D000818:Animals; D001705:Bioprosthesis / Q000009:adverse effects*; D006333:Heart Failure / Q000601:surgery*; D016027:Heart Transplantation / Q000379:methods; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006351:Heart Valves / Q000473:pathology*; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D011475:Prosthesis Failure; D016896:Treatment Outcome