title: Visceral and subcutaneous fat in patients treated with olanzapine: a case series.
abstract: OBJECTIVE
  We hypothesized that olanzapine may contribute to visceral adiposity, a core symptom of metabolic syndrome.
  
  
  METHODS
  Using computed tomography, we examined the effect of olanzapine on visceral and subcutaneous fat distribution, body mass index, fasting glucose, and lipids in an unselected population of 14 schizophrenic patients.
  
  
  RESULTS
  We found a 6-week olanzapine treatment to be related to increased body mass index and proportion of total fat at the level of the fourth vertebral body.
  
  
  CONCLUSIONS
  On the basis of these findings, we conclude that weight gain after a 6-week olanzapine treatment is partly attributable to increased visceral fat and may thus contribute to metabolic syndrome.
authors.affiliation: Department of Psychiatry and Psychotherapy, and †Neuroradiology, Central Institute of Mental Health, Mannheim, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Gilles
authors.forename: Frank
authors.initials: F
authors.lastname: Hentschel
authors.forename: Georgios
authors.initials: G
authors.lastname: Paslakis
authors.forename: Valerie
authors.initials: V
authors.lastname: Glahn
authors.forename: Florian
authors.initials: F
authors.lastname: Lederbogen
authors.forename: Michael
authors.initials: M
authors.lastname: Deuschle
mesh_terms: D050154:Adiposity; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000187:drug effects*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D000077152:Olanzapine; D012559:Schizophrenia / Q000188:drug therapy; D050507:Subcutaneous Fat, Abdominal / Q000000981:diagnostic imaging / Q000187:drug effects*; D014057:Tomography, X-Ray Computed; D015430:Weight Gain / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine