title: Candida glabrata complicating in vitro pregnancy: successful management of subsequent pregnancy.
abstract: OBJECTIVE
  To report the occurrence of Candida glabrata chorioamnionitis complicating an in vitro fertilization (IVF) pregnancy.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 30-year-old woman, primagravida, with an IVF dichorionic-diamniotic pregnancy who presented at 15 weeks with vaginal bleeding.
  
  
  METHODS
  Before embryo transfer in next IVF cycle, vaginal culture from the patient revealed colonization with C. glabrata, which was treated with boric acid.
  
  
  METHODS
  Subsequent pregnancy after eradication of fungal organisms.
  
  
  RESULTS
  The patient's first pregnancy was treated with indomethacin and broad-spectrum antibiotics, but her membranes ruptured, and she delivered both twins at 16 weeks; the autopsy and pathology reports were consistent with C. glabrata chorioamnionitis. After boric acid treatment eradicated the organisms, two embryos were transferred in subsequent IVF treatment; the second pregnancy was uncomplicated, with dichorionic-diamniotic twins, delivered by cesarean section at 38 weeks.
  
  
  CONCLUSIONS
  Eradication of vaginal colonization with C. glabrata may prevent infection of the next IVF pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA. oasemota@drexelmed.edu
authors.forename: Obehi A
authors.initials: OA
authors.lastname: Asemota
authors.forename: Paul
authors.initials: P
authors.lastname: Nyirjesy
authors.forename: Rachel
authors.initials: R
authors.lastname: Fox
authors.forename: Jack D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001888:Boric Acids / Q000627:therapeutic use; D041221:Candida glabrata / Q000502:physiology; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005307:Fertilization in Vitro; D005313:Fetal Death / Q000517:prevention & control; D006801:Humans; D010298:Parity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy*; D011272:Pregnancy, Multiple / Q000502:physiology; D016896:Treatment Outcome; D014427:Twins
chemical_list: D000935:Antifungal Agents; D001888:Boric Acids; C032688:boric acid