title: Anti-asthmatic effects of an Amomum compactum extract on an ovalbumin (OVA)-induced murine asthma model.
abstract: Despite ongoing intensive asthma research, the incidence of asthma is increasing worldwide. We investigated in this study the effects of Amomum compactum on ovalbumin (OVA)-induced asthma in a mouse model, and studied the possible mechanism for its anti-asthmatic action. Our data show that an A. compactum treatment markedly decreased the number of infiltrating eosinophils and the hypersecretion of mucus when compared with the effects on mice treated with OVA alone. The A. compactum treatment dose-dependently decreased the levels of reactive oxygen species (ROS) and T helper (Th)2 cytokines, including interleukin (IL)-4 and IL-5, in the bronchoalveolar lavage fluid (BALF), and a high dose of A. compactum effectively reduced the level of total immunoglobulin (Ig)E in the serum. Taken together, these data indicate that the administration of A. compactum may have potential therapeutic value when used as an adjuvant for the immunomodulatory treatment of allergic asthma.
authors.affiliation: Herbal Medicine Evidence Based Medicine Research Center, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
authors.forename: Jin-Ah
authors.initials: JA
authors.lastname: Lee
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Da Young
authors.initials: DY
authors.lastname: Jung
authors.forename: Nam-Hun
authors.initials: NH
authors.lastname: Lee
authors.forename: Jung-Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Ha
authors.forename: Hyeun Kyoo
authors.initials: HK
authors.lastname: Shin
mesh_terms: D035801:Amomum / Q000737:chemistry*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000187:drug effects; D007073:Immunoglobulin E / Q000097:blood; D007155:Immunologic Factors; D051379:Mice; D009093:Mucus / Q000187:drug effects / Q000378:metabolism; D010047:Ovalbumin / Q000009:adverse effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D017382:Reactive Oxygen Species / Q000032:analysis; D018418:Th2 Cells / Q000276:immunology
chemical_list: D007155:Immunologic Factors; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D007073:Immunoglobulin E; D010047:Ovalbumin