Serotonin and catecholaminergic polymorphic ventricular tachycardia: a possible therapeutic role for SSRIs?
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare malignant arrhythmia, usually diagnosed in the adolescent years. The diagnosis can typically be made by one or more of the following: a positive family history, exercise electrocardiography, ambulatory ECG monitoring and/or an intra-cardiac, electrophysiological examination. This is a case report of a patient with CPVT that was refractory to treatment with beta-blockade and an implanted automatic cardioverter defibrillator. However, after a selective serotonin re-uptake inhibitor (SSRI) was added to the therapeutic regimen, no further episodes of ventricular tachycardia occurred during the following two years.
Chen
S
S
Department of Cardiology, 10th People's Hospital of Tongji University, Shanghai, China.
Duan
Q
Q
Tang
K
K
Zhao
D
D
Xu
Y
Y
D000328:Adult; D002395:Catecholamines / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
D002395:Catecholamines; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors