title: Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes.
abstract: Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Ricci
authors.forename: Jeehyun
authors.initials: J
authors.lastname: Park
authors.forename: Won-Yoon
authors.initials: WY
authors.lastname: Chung
authors.forename: Kwang-Kyun
authors.initials: KK
authors.lastname: Park
authors.forename: Mankil
authors.initials: M
authors.lastname: Jung
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D037621:Artemisinins / Q000737:chemistry*; D002642:Chick Embryo; D002823:Chorion / Q000187:drug effects*; D006017:Glycolipids / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D037621:Artemisinins; D006017:Glycolipids; C031327:artemisinin