title: Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.
abstract: Our aim was to assess bone parameters in children with chronic kidney disease (CKD) with both dual-energy X-ray absorptiometry (DXA) and quantitative ultrasonography (QUS) and additionally with biochemical markers of bone turnover. Twenty children (12 boys and 8 girls) with CKD and a mean decimal age of 9.47 ± 4.44 years were included in the study where anthropometric parameters (height and weight), pubertal status, bone mineral density (BMD) at lumbar spine, speed of sound (SOS) measured by QUS at radius and at tibia, and biochemical markers of bone metabolism were measured. Six patients (30%) had tibial SOS Z score <-1, and 52.7% had radial SOS Z score <-1, whereas only 16.67% had BMD Z score <-1. Patients had significantly increased levels of serum intact parathormone (p < 0.001), serum bone alkaline phosphatase (BAP) (p < 0.001) and serum N-terminal-mid fragment (aminoacids 1-43) of osteocalcin (p < 0.001) compared to controls, whereas serum osteoprotegerin was significantly decreased in patients compared to controls (p = 0.001). SOS was significantly correlated to BAP (r = -0.586, p = 0.013 and r = -0.709, p = 0.001, respectively, for radius and tibia). In conclusion no association between DXA and QUS measurements was documented in our study, whereas QUS was better correlated to biochemical indices of ROD.
authors.affiliation: 1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str., 54642 Thessaloniki, Greece. christoforidis@doctors.org.uk
authors.forename: Athanasios
authors.initials: A
authors.lastname: Christoforidis
authors.forename: Nikoleta
authors.initials: N
authors.lastname: Printza
authors.forename: Chrysa
authors.initials: C
authors.lastname: Gkogka
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Siomou
authors.forename: Anna
authors.initials: A
authors.lastname: Challa
authors.forename: Eirini
authors.initials: E
authors.lastname: Kazantzidou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kollios
authors.forename: Fotis
authors.initials: F
authors.lastname: Papachristou
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D011884:Radius / Q000000981:diagnostic imaging; D013977:Tibia / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D010281:Parathyroid Hormone