title: Management of split-thickness donor sites with synthetic wound dressings: results of a comparative clinical study.
abstract: This prospective, randomized, single-blinded, clinical study aimed at evaluating 3 different synthetic wound dressings for treating split-thickness skin graft donor sites. Seventy-seven patients were randomly assigned to 3 study groups: Suprathel, Biatain-Ibu, Mepitel. Wounds were inspected daily until complete reepithelization. Ease of care, treatment costs, and scar development after a 6 months follow-up were evaluated. Suprathel showed significant (P ≤ 0.001) pain reduction after 24 hours but increasing pain scores on the 5th day of treatment. Biatain-Ibu showed significant pain relief immediately after application and during the entire treatment period (P < 0.05). Mepitel did not show any significant pain reduction. No differences were seen with regard to healing time, quality of reepithelization, and scar development. Biatain-Ibu had the lowest overall treatment costs (P ≤ 0.001). The investigated materials did not differ with regard to quality and acceleration of the healing process, but Biatain-Ibu seems to be the most appropriate dressing material in terms of cost-effectiveness.
authors.affiliation: Department of Plastic Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Markl
authors.forename: Lukas
authors.initials: L
authors.lastname: Prantl
authors.forename: Stephan
authors.initials: S
authors.lastname: Schreml
authors.forename: Philipp
authors.initials: P
authors.lastname: Babilas
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
authors.forename: Hardy
authors.initials: H
authors.lastname: Schwarze
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D012016:Reference Values; D012828:Silicones; D016037:Single-Blind Method; D016038:Skin Transplantation / Q000379:methods*; D018709:Statistics, Nonparametric; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods*; D014945:Wound Healing / Q000502:physiology; D014947:Wounds and Injuries / Q000601:surgery*; D055815:Young Adult
chemical_list: D012828:Silicones; C114834:mepitel