[Pharmacogenomics and chemotherapy].
Genetic factors could alter drug metabolism and activity and could predict drug toxicity and/or efficacy. Several chemotherapy agents are administered in different schedules for the treatment of different cancer histotypes. The most used drug in the treatment of gastro-intestinal, head and neck and breast neoplasms is the 5-fluorouracil (5-FU). Capecitabine is a prodrug of 5-FU. Cisplatin based chemotherapy is administered in the treatment of lung, genitourinary tract, head and neck, occult neoplasms, mesothelioma and melanoma. Taxanes are used in lung, breast, head and neck, genitourinary tract neoplasms and sarcomas. Determination of polymorphisms in metabolizing enzymes before the administration of chemotherapy could offer new strategies for optimizing the treatment of individual patients.
Paris
Ida
I
UOC Oncologia Medica, Ospedale Sant'Andrea, II Facoltà di Medicina e Chirurgia, Sapienza Università di Roma. ida_paris@yahoo.it
Cappellini
Gian Carlo Antonini
GC
Malaguti
Paola
P
Bassanelli
Maria
M
Marchetti
Paolo
P
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity; D002945:Cisplatin; D042943:Dihydrouracil Dehydrogenase (NADP); D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000633:toxicity; D005472:Fluorouracil / Q000378:metabolism / Q000633:toxicity; D005838:Genotype; D000077146:Irinotecan; D009369:Neoplasms / Q000188:drug therapy* / Q000401:mortality; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D016019:Survival Analysis; D043823:Taxoids / Q000627:therapeutic use; D013940:Thymidylate Synthase / Q000235:genetics; D013997:Time Factors; D014116:Toxicology
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D043823:Taxoids; D000077146:Irinotecan; D042943:Dihydrouracil Dehydrogenase (NADP); D013940:Thymidylate Synthase; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin