Development of a Si-PM-based high-resolution PET system for small animals.
A Geiger-mode avalanche photodiode (Si-PM) is a promising photodetector for PET, especially for use in a magnetic resonance imaging (MRI) system, because it has high gain and is less sensitive to a static magnetic field. We developed a Si-PM-based depth-of-interaction (DOI) PET system for small animals. Hamamatsu 4 × 4 Si-PM arrays (S11065-025P) were used for its detector blocks. Two types of LGSO scintillator of 0.75 mol% Ce (decay time: ∼45 ns; 1.1 mm × 1.2 mm × 5 mm) and 0.025 mol% Ce (decay time: ∼31 ns; 1.1 mm × 1.2 mm × 6 mm) were optically coupled in the DOI direction to form a DOI detector, arranged in a 11 × 9 matrix, and optically coupled to the Si-PM array. Pulse shape analysis was used for the DOI detection of these two types of LGSOs. Sixteen detector blocks were arranged in a 68 mm diameter ring to form the PET system. Spatial resolution was 1.6 mm FWHM and sensitivity was 0.6% at the center of the field of view. High-resolution mouse and rat images were successfully obtained using the PET system. We confirmed that the developed Si-PM-based PET system is promising for molecular imaging research.
Yamamoto
Seiichi
S
Kobe City College of Technology, Kobe, Japan. s-yama@kobe-kosen.ac.jp
Imaizumi
Masao
M
Watabe
Tadashi
T
Watabe
Hiroshi
H
Kanai
Yasukazu
Y
Shimosegawa
Eku
E
Hatazawa
Jun
J
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D004560:Electricity; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging; D008027:Light; D051379:Mice; D049268:Positron-Emission Tomography / Q000295:instrumentation*; D051381:Rats; D013696:Temperature
D019788:Fluorodeoxyglucose F18