title: Zinc transmetallation and gadolinium retention after MR imaging: case report.
abstract: A patient with chronic zinc poisoning from denture cream retained gadolinium after a magnetic resonance imaging procedure, likely due to transmetallation. During chelation therapy, high levels of gadolinium in excreted urine (up to 89 μg/d, 29 days after gadolinium administration) were present, indicating that gadolinium had been retained. Almost 2½ years after gadolinium exposure, a 24-hour urine collection indicated that the gadolinium level remained in the elevated range (0.6 μg/d). This single case report suggests that patients with elevated zinc exposure may be at increased risk of gadolinium retention.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Children's Hospital Informatics Program, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA. sagreenberg@partners.org
authors.forename: Steven A
authors.initials: SA
authors.lastname: Greenberg
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry / Q000506:poisoning*; D015913:Chelation Therapy; D019786:Gadolinium DTPA / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011108:Polymers / Q000737:chemistry / Q000506:poisoning*; D015032:Zinc / Q000506:poisoning* / Q000652:urine
chemical_list: D011108:Polymers; C071530:Super Poli-Grip; D015032:Zinc; D019786:Gadolinium DTPA; D002266:Carboxymethylcellulose Sodium