title: Importance of the caspase cleavage site in amyloid-β protein precursor.
abstract: Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-β protein precursor (AβPP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in AβPP.
authors.affiliation: Buck Institute for Age Research, Novato, CA 94945, USA. dbredesen@buckinstitute.org
authors.forename: Dale E
authors.initials: DE
authors.lastname: Bredesen
authors.forename: Varghese
authors.initials: V
authors.lastname: John
authors.forename: Veronica
authors.initials: V
authors.lastname: Galvan
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001284:Atrophy; D020169:Caspases / Q000737:chemistry / Q000378:metabolism*; D016923:Cell Death / Q000235:genetics; D016503:Drug Delivery Systems; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D017774:Long-Term Potentiation / Q000235:genetics; D008569:Memory Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D013569:Synapses / Q000235:genetics / Q000473:pathology
chemical_list: D016564:Amyloid beta-Protein Precursor; D020169:Caspases