[Detection of the serum level of interleukin-17 and interleukin-6 in the chronic hepatitis B patients].
OBJECTIVE
To research serum level of interleukin-17 (IL-17) associated with the progression of hepatic injury in the chronic patients with hepatitis B.


METHODS
The serum level of IL-17 was measured by ELISA and the serum levels of IL-6, IL-8 were measured by RIA in patient groups and healthy group, the patient groups including 42 mild patients, 37 moderate patients and 38 severe patients.


RESULTS
IL-17,IL-6 and IL-8 levels in patient patients were significantly higher than those in healthy people (P < 0.01). There is no significant difference among mild patients and moderate patients. Compared with mild patients and moderate patients,the cytokines lever were significantly higher in severe patients (P < 0.01).


CONCLUSIONS
IL-17 as a new cytokine probably play a multiple role as immune factor and inflammation element in the progression of the chronic hepatitis B disease. Maybe, it can provide a new approach to the therapy of the chronic hepatitis B.
Weng
Xiu-mei
XM
Department of Clinical Laboratory, Zhejiang Hospital, HangZhou 310013, China.
Chen
Gang
G
Ma
Xiao-Hong
XH
Zhou
Huan-Qin
HQ
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged
D020381:Interleukin-17; D015850:Interleukin-6; D016209:Interleukin-8