Effect of endurance exercise training on oxidative stress in spontaneously hypertensive rats (SHR) after emergence of hypertension.
The purpose of this study is to elucidate the effect of wheel training on oxidative stress maker levels in spontaneous hypertensive rats (SHR). 4-hydroxynonenal and 3-nitrotyrosine levels in the aorta of SHRs were allowed to run for 10 weeks from the age of 15 weeks were measured and compared with those of nonexercised SHRs. The 4-hydroxynonenal and 3-nitrotyrosine levels in the exercised group were significantly lower than those in the nonexercised group. The exercised group showed a significant increase of manganese-containing superoxide dismutase. Endurance exercise showed a possible suppressing effect on the arteriosclerosis development by reducing oxidative stress, even after emergence of hypertension.
Kimura
Hiroko
H
Department of Forensic Medicine, Juntendo University School of Medicine, Tokyo, Japan. hkim@juntendo.ac.jp
Kon
Nobuko
N
Furukawa
Satoshi
S
Mukaida
Masahiro
M
Yamakura
Fumiyuki
F
Matsumoto
Kazuko
K
Sone
Hirohito
H
Murakami-Murofushi
Kimiko
K
D000367:Age Factors; D000447:Aldehydes / Q000032:analysis*; D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure; D003324:Coronary Artery Disease / Q000209:etiology / Q000517:prevention & control; D015200:Fluoroimmunoassay; D006973:Hypertension / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D009043:Motor Activity; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal; D010807:Physical Endurance; D051381:Rats; D011918:Rats, Inbred SHR; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis; D000099156:Superoxide Dismutase 2
D000447:Aldehydes; D009569:Nitric Oxide; D013482:Superoxide Dismutase; D013481:Superoxides; D014443:Tyrosine; D000099156:Superoxide Dismutase 2; C002744:3-nitrotyrosine; C027576:4-hydroxy-2-nonenal