title: Cutaneous myelofibrosis with JAK2 V617F mutation: metastasis, not merely extramedullary hematopoiesis!
abstract: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm. There are 31 reported cases of cutaneous involvement by PMF, most of which have been described as "extramedullary hematopoiesis." We report a new case of cutaneous involvement by PMF and demonstrate mutation of the Janus kinase 2 gene in the cutaneous lesions. Extramedullary myelofibrosis is best considered a metastatic phenomenon. Reporting such cases as extramedullary hematopoiesis may cause confusion with reactive forms of extramedullary hematopoiesis.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA. gfraga@kumc.edu
authors.forename: Garth R
authors.initials: GR
authors.lastname: Fraga
authors.forename: Samuel K
authors.initials: SK
authors.lastname: Caughron
mesh_terms: D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D008297:Male; D009154:Mutation; D055728:Primary Myelofibrosis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology
chemical_list: D053614:Janus Kinase 2