title: Polymorphisms of superoxide dismutase, glutathione peroxidase and catalase genes in patients with post-transplant diabetes mellitus.
abstract: OBJECTIVE
  Post-transplant diabetes mellitus (PTDM) is a metabolic disorder that develops in response to a relative insulin deficiency in patients after organ transplantation treated with immunosuppressive drugs. Several studies have suggested that oxidative stress may be associated with diabetes and its complications. The aim of this study was to examine the association of polymorphisms in superoxide dismutase, catalase and glutathione peroxidase genes with PTDM in patients after kidney transplantation.
  
  
  METHODS
  The study included 159 patients receiving kidney transplants. PTDM was diagnosed in 21 patients.
  
  
  RESULTS
  Analyzing the C599T (Pro200Leu) polymorphism in the GPX1 gene PTDM was diagnosed in 8.45% of patients with CC genotype, 13.43% with CT and in 28.57% with TT. Allele T was significantly more frequent among patients with PTDM compared to patients without PTDM (OR = 2.14, 95% CI = 1.11-4.12, p = 0.024). There were no associations between SOD1, SOD2 and CAT polymorphisms and PTDM.
  
  
  CONCLUSIONS
  The present results suggest that Pro200Leu polymorphism of the GPX1 gene may be associated with the risk of PTDM development in renal graft recipients.
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Dutkiewicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Domanski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Binczak-Kuleta
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.forename: Maria
authors.initials: M
authors.lastname: Pietrzak-Nowacka
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D001483:Base Sequence; D002374:Catalase / Q000235:genetics*; D017931:DNA Primers; D003920:Diabetes Mellitus / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*; D014180:Transplantation / Q000009:adverse effects*
chemical_list: D017931:DNA Primers; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase