title: Oxidative stress biomarkers and chromogranin A in uremic patients: effects of dialytic treatment.
abstract: OBJECTIVE
  To evaluate oxidative stress in uremia and dialysis and chromogranin A, a stress hormone that could be related to oxidative processes.
  
  
  METHODS
  Plasma oxidative stress biomarkers (-SH, 8-OHdG, and ox-LDL) and chromogranin A were measured in 89 outpatients (21 uremic patients, 17 in peritoneal dialysis, and 51 in haemodialysis), and in 18 subjects with normal renal function.
  
  
  RESULTS
  -SH groups were significantly reduced in heamodialysis, peritoneal, and uremic patients as compared with the control group (p=0.01), while 8-OHdG was increased (p<0.01). No differences were observed for ox-LDL. Chromogranin A was increased in uremic, peritoneal and haemodialysis patients (p<0.01), showing a positive correlation to 8-OHdG (p<0.01).
  
  
  CONCLUSIONS
  Oxidative stress biomarkers and chromogranin A levels differ between control subjects when compared to both uremic and dialysis patients. No differences were observed between uremic and dialysis patients, suggesting that uremia is the major source of the increase in oxidative stress and CgA levels in patients with end stage renal disease.
authors.affiliation: Clinica Nefrologica, Azienda Ospedaliera San Gerardo, Dipartimento di Medicina Clinica e Prevenzione, Università degli Studi di Milano-Bicocca, Monza, Italy. giovanna.castoldi@unimib.it
authors.forename: Giovanna
authors.initials: G
authors.lastname: Castoldi
authors.forename: Laura
authors.initials: L
authors.lastname: Antolini
authors.forename: Camila
authors.initials: C
authors.lastname: Bombardi
authors.forename: Lucia
authors.initials: L
authors.lastname: Perego
authors.forename: Paola
authors.initials: P
authors.lastname: Mariani
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Viganò
authors.forename: Giacomo
authors.initials: G
authors.lastname: Torti
authors.forename: Marco
authors.initials: M
authors.lastname: Casati
authors.forename: Angelo
authors.initials: A
authors.lastname: Corti
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Zerbini
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Valsecchi
authors.forename: Andrea
authors.initials: A
authors.lastname: Stella
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D053379:Chromogranin A / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D053379:Chromogranin A