title: Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro.
abstract: Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Han
authors.forename: Lihui
authors.initials: L
authors.lastname: Hou
authors.forename: Jean-Patrice
authors.initials: JP
authors.lastname: Baillargeon
authors.forename: Haixue
authors.initials: H
authors.lastname: Kuang
authors.forename: Yongyan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Wu
mesh_terms: D001599:Berberine / Q000494:pharmacology*; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D017588:Hyperandrogenism / Q000378:metabolism*; D066298:In Vitro Techniques; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D013799:Theca Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D001599:Berberine; D003907:Dexamethasone; D005947:Glucose