A cellular view of Nf2 in liver homeostasis and tumorigenesis.
How liver adjusts and stabilizes its size is unsolved so far; the answers to this question may also provide insights into mechanisms of hepatocarcinogenesis. Two recent papers suggest a role for Merlin/Nf2 in control of liver cell turnover, but results appear conflicting at first glance.
Breuhahn
Kai
K
Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Schirmacher
Peter
P