Rhodium-catalysed conjugate addition of arylboronic acids to enantiopure dehydroamino acid derivatives.
The rhodium-catalysed conjugate addition of arylboronic acids to an enantiopure acceptor derived from (R)-S-methylcysteine proceeds under substrate control to provide a range of functionalised phenylalanine derivatives with excellent stereocontrol via a highly diastereoselective protonation.
Hargrave
Jonathan D
JD
Department of Chemistry, University of Bath, Claverton Down, Bath, UKBA2 7AY.
Bish
Gerwyn
G
Köhn
Gabriele Kociok
GK
Frost
Christopher G
CG
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008956:Models, Chemical; D023303:Oxazolidinones / Q000737:chemistry; D011522:Protons; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D001897:Boronic Acids; D023303:Oxazolidinones; D011522:Protons; D012238:Rhodium