title: In vitro sensitivity and resistance of 46 Leptospira strains isolated from rats in the Philippines to 14 antimicrobial agents.
abstract: The in vitro susceptibilities of 46 Leptospira isolates from rats to 14 antimicrobial agents were tested. All of the strains were found to be sensitive to ampicillin, cefotaxime, ciprofloxacin, norfloxacin, doxycycline, erythromycin, and streptomycin. In contrast, the tested isolates showed resistance to amphotericin B, 5-fluorouracil, fosfomycin, trimethoprim, sulfamethoxazole, neomycin, and vancomycin. These findings will help in selecting effective and ineffective antimicrobials for treatment of leptospirosis and for the development of new selective media, respectively.
authors.affiliation: Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. antara@bact.med.kyushu-u.ac.jp
authors.forename: Antara
authors.initials: A
authors.lastname: Chakraborty
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miyahara
authors.forename: Sharon Y A M
authors.initials: SY
authors.lastname: Villanueva
authors.forename: Nina G
authors.initials: NG
authors.lastname: Gloriani
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology; D007919:Leptospira / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology; D010679:Philippines; D051381:Rats; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D002939:Ciprofloxacin; D004917:Erythromycin; D014640:Vancomycin; D000667:Ampicillin; D000666:Amphotericin B; D014295:Trimethoprim; D009355:Neomycin; D013420:Sulfamethoxazole; D004318:Doxycycline; D002439:Cefotaxime; D005472:Fluorouracil