Investigation of carcinogenicity for levamisole administered in the diet to F344 rats.
A two year carcinogenicity study of anthelmintic drug levamisole (LV) was performed using 50 male and 50 female F344 rats at dietary drug concentrations of 0, 60, or 300 ppm. The daily intakes of LV were calculated to be 2.6, 12.9 mg/kg b.w./day for males and 2.9, 14.1mg/kg b.w./day for females, respectively. No significant differences in general condition and survival rate (82%, 74%, 80% in males and 84%, 84%, 84% in females, respectively) were observed. In the 300 ppm group, suppression of body weight gain was observed from the onset of treatment and reduction in final body weights was 6% in males and 11% in females. Significant increases in the absolute and/or relative weights of the lungs, heart, spleen, liver, kidneys, and adrenals were observed in males and/or females treated with 300 ppm. Some of high incidences neoplasms were observed, and there were also tendencies to increase for mammary gland fibroma and thoracic/abdominal cavity mesothelioma in males. However, there were no significant inter-group differences in incidences, histopathological types or differences compared with historical control data. Thus, it was concluded that LV was not carcinogenic to male and female F344 rats under the experimental conditions.
Hibi
D
D
Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
Imazawa
T
T
Kijima
A
A
Suzuki
Y
Y
Ishii
Y
Y
Jin
M
M
Umemura
T
T
Nishikawa
A
A
D000818:Animals; D000969:Antinematodal Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D015197:Carcinogenicity Tests; D002273:Carcinogens; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005260:Female; D006128:Growth / Q000187:drug effects; D007978:Levamisole / Q000633:toxicity*; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D013534:Survival
D000969:Antinematodal Agents; D002273:Carcinogens; D007978:Levamisole