title: Binary mixing of micelles using Pluronics for a nano-sized drug delivery system.
abstract: Pluronics with different structural compositions and properties are used for several applications, including drug delivery systems. We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and high solubilization capacity due to Pluronic L121. The binary systems were spherical and less than 200-nm diameter, with high thermodynamic stability (at least 2 weeks) in aqueous solution. The CMC of the binary system was located in the middle of the CMC of each polymer. In particular, the solubilization capacity of the binary system (0.1/0.1 wt%) was higher than mono-systems of P123. The main advantage of binary systems is overcoming limitations of mono systems to allow tailored mixing of block copolymers with different physicochemical characteristics. These nano-sized systems may have potential as anticancer drug delivery systems with simple preparation method, high stability, and high loading capacity.
authors.affiliation: Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.forename: Yu Seok
authors.initials: YS
authors.lastname: Youn
authors.forename: Myounghwa
authors.initials: M
authors.lastname: Nam
authors.forename: Byungtae
authors.initials: B
authors.lastname: Park
authors.forename: Jungmin
authors.initials: J
authors.lastname: Yun
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Ho-Taek
authors.initials: HT
authors.lastname: Song
authors.forename: Kyung Taek
authors.initials: KT
authors.lastname: Oh
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D016503:Drug Delivery Systems; D005453:Fluorescence; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D009391:Nephelometry and Turbidimetry; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013057:Spectrum Analysis
chemical_list: D001391:Azo Compounds; D008823:Micelles; D012996:Solutions; D020442:Poloxamer; C033006:sudan III