The Australian Pregnancy Register of Anti-epileptic Drugs: 10 years of progress.
The need for collecting a nationwide database for antiepileptic drug (AED) use in pregnancy is described as well as the rationale, methods, funding and logistics of the Australian Pregnancy Register of Anti-epileptic Drugs (APR). Various aspects of treatment with AED have been reported, not only in relation to teratogenicity but also in terms of efficacy of AED, their use in mono and polytherapy, dose-effect relationships and foetal outcomes. The overall effect of the APR in terms of scientific education is also discussed.
Vajda
F J E
FJ
Department of Medicine (RMH/WH), The University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville, Victoria 3050, Australia. vajda@netspace.net.au
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000927:Anticonvulsants / Q000009:adverse effects*; D001315:Australia / Q000453:epidemiology; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000187:drug effects*; D012042:Registries / Q000941:ethics
D000927:Anticonvulsants