title: Understanding forgiveness: minding and mining the gaps between pharmacokinetics and therapeutics.
abstract: The usual objective during long-term pharmacotherapy is, in large part, to maintain continuity of action of the prescribed drug(s). Continuity of action arises from the continuity of execution of a prescribed dosing regimen that is pharmacologically sound in dose quantity and interval between successive doses. Interruptions in dosing can interrupt drug action, but the consequences vary according to length of interruption, drug, drug formulation, length of the patient's prior exposure to the drug, and the disease being treated.
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. larso@stanford.edu
authors.forename: L G
authors.initials: LG
authors.lastname: Osterberg
authors.forename: J
authors.initials: J
authors.lastname: Urquhart
authors.forename: T F
authors.initials: TF
authors.lastname: Blaschke
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002908:Chronic Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D055118:Medication Adherence; D055553:Prescription Drugs / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000319:Adrenergic beta-Antagonists; D019380:Anti-HIV Agents; D000959:Antihypertensive Agents; D055553:Prescription Drugs