title: Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics.
abstract: Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2'-modified nucleosides. In particular, disubstitution at the C-2' position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2'-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
authors.forename: Orrette R
authors.initials: OR
authors.lastname: Wauchope
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Tomney
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Pepper
authors.forename: Brent E
authors.initials: BE
authors.lastname: Korba
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Seley-Radtke
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D016174:Hepacivirus / Q000187:drug effects*; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*
chemical_list: D000998:Antiviral Agents; D006575:Heterocyclic Compounds, 3-Ring; D009705:Nucleosides