title: South Carolina tuberculosis genotype cluster investigation: a tale of substance abuse and recurrent disease.
abstract: The South Carolina Tuberculosis (TB) Control Division ranked all the TB genotype clusters (two or more cases with matching genotypes) in the state based on the number of cases. The largest cluster, PCR00002, was investigated to determine if the cluster represented recent Mycobacterium tuberculosis transmission, and if so, to identify associated risk factors. The PCR0002 cluster, which included pediatric cases, clearly represented recent M. tuberculosis transmission. The two primary factors contributing to cluster growth were substance abuse and recurrent TB disease. Elimination of ongoing M. tuberculosis transmission in this population will require concurrent treatment for TB disease and substance abuse.
authors.affiliation: Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia ngck6@ha.org.hk, USA. ali3@cdc.gov, jeo3@cdc.gov
authors.forename: A M
authors.initials: AM
authors.lastname: Buff
authors.forename: P K
authors.initials: PK
authors.lastname: Moonan
authors.forename: M A
authors.initials: MA
authors.lastname: Desai
authors.forename: T L
authors.initials: TL
authors.lastname: McKenna
authors.forename: D A
authors.initials: DA
authors.lastname: Harris
authors.forename: B J
authors.initials: BJ
authors.lastname: Rogers
authors.forename: S S
authors.initials: SS
authors.lastname: Rabley
authors.forename: J E
authors.initials: JE
authors.lastname: Oeltmann
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003140:Communicable Disease Control / Q000379:methods; D005260:Female; D005838:Genotype; D006801:Humans; D055985:Latent Tuberculosis / Q000453:epidemiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D010641:Phenotype; D012008:Recurrence; D012307:Risk Factors; D013022:South Carolina / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000628:therapy; D017211:Treatment Failure; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control / Q000635:transmission; D055815:Young Adult