Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis.
Gavrilyuk
Julia
J
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Uehara
Hisatoshi
H
Otsubo
Nobumasa
N
Hessell
Ann
A
Burton
Dennis R
DR
Barbas
Carlos F
CF
D017151:Antibodies, Catalytic / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D065100:CCR5 Receptor Antagonists; D002384:Catalysis; D002460:Cell Line; D054659:Diketopiperazines; D005456:Fluorescent Dyes / Q000737:chemistry; D005634:Fructose-Bisphosphate Aldolase / Q000737:chemistry* / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry; D023581:HIV Fusion Inhibitors / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D011485:Protein Binding; D019713:Receptors, CCR5 / Q000378:metabolism; D012235:Rhodamines / Q000737:chemistry; D015302:Simian Immunodeficiency Virus / Q000187:drug effects; D013141:Spiro Compounds / Q000737:chemistry*
D017151:Antibodies, Catalytic; D001565:Benzoates; D065100:CCR5 Receptor Antagonists; D054659:Diketopiperazines; D005456:Fluorescent Dyes; D015699:HIV Envelope Protein gp120; D023581:HIV Fusion Inhibitors; D007140:Immunoglobulin Fab Fragments; D010879:Piperazines; D019713:Receptors, CCR5; D012235:Rhodamines; D013141:Spiro Compounds; C514793:gp120 protein, Human immunodeficiency virus 1; C499671:aplaviroc; D011392:Proline; C109536:antibody aldolase; D005634:Fructose-Bisphosphate Aldolase