The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.
The Drosophila neuromuscular junction (NMJ) has recently provided new insights into the roles of various proteins in neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), Spinal Muscular Atrophy (SMA), Multiple Sclerosis (MS) Hereditary Spastic Paraplegia (HSP), and Huntington's Disease (HD). Several developmental signaling pathways including WNT, MAPK and BMP/TGF-β signaling play important roles in the formation and growth of the Drosophila NMJ. Studies of the fly homologues of genes that cause neurodegenerative disease at the NMJ have resulted in a better understanding of the roles of these proteins in vivo. These studies may shed light on the pathological mechanisms of these diseases, with implications for reduced BMP/TGF-β signaling in ALS, SMA and HD and increased signaling in HSP and MS.
Bayat
Vafa
V
Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
Jaiswal
Manish
M
Bellen
Hugo J
HJ
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D004330:Drosophila / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta