title: Sodium alginate as viscosity modifier may induce aggregation of red blood cells.
abstract: Viscosity of blood substitutes is among the important determinants to restore microcirculation. Sodium alginate (SA) is always mentioned as "viscosity modifier" in creating blood substitutes. In the present study, the whole blood was diluted using SA solutions to final hematocrits of 10%, 20%, and 35%, respectively. The whole blood viscosity (WBV) at different shear rates, plasma viscosity (PV), and rheological behavior of red blood cells (RBCs) was studied in vitro. The results show that SA may induce RBCs aggregation in a dose-dependent manner. Furthermore, the effect of SA on RBCs aggregation maybe involve the regulation of microcirculation.
authors.affiliation: Department of Immunohematology, Beijing Institute of Transfusion Medicine, Beijing, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhao
authors.forename: Guoxing
authors.initials: G
authors.lastname: You
authors.forename: Fulong
authors.initials: F
authors.lastname: Liao
authors.forename: Xuemei
authors.initials: X
authors.lastname: Kan
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Quanmei
authors.initials: Q
authors.lastname: Sun
authors.forename: Huibin
authors.initials: H
authors.lastname: Xu
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000464:Alginates / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D020723:Glucuronic Acid / Q000494:pharmacology; D006400:Hematocrit; D006603:Hexuronic Acids / Q000494:pharmacology; D006801:Humans; D013535:Suspensions
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D013535:Suspensions; D020723:Glucuronic Acid