title: The role of acute pancreatitis in pediatric burn patients.
abstract: Few publications recognize acute pancreatitis as a complication after large burns, consequently the incidence and outcome acute pancreatitis after burn in children is not well defined. The aim of this study was to determine the incidence, morbidity, and mortality relating to acute pancreatitis in a pediatric burn population and to correlate clinical diagnosis with autopsy findings to determine the incidence of unrecognized pancreatitis. Records of 2699 patients with acute burns were reviewed. Acute pancreatitis was defined as abdominal pain and/or feeding intolerance in addition to a three-fold elevation of amylase and/or lipase. One-hundred twenty-seven burned children served as the control cohort. To assess the presence of autopsy confirmed AP in pediatric burn patients, we evaluated autopsy reports of 78 children who died from burns, looking for reported evidence of pancreatic inflammation, and fat/parenchymal necrosis. Our data show that acute pancreatitis in children has a low incidence after burn. The study included 2699 patients of which 13 were suffering acute pancreatitis (13/2699 = 0.05%). Mortality is significantly higher for the acute pancreatitis group vs. the control group, p < 0.05. Autopsy reports established 11 of 78 patients with evidence of pancreatitis, resulting in an incidence of 0.17% for pancreatitis at autopsy. Although it has low incidence, acute pancreatitis is associated with increased mortality in severely burned pediatric patients, which underlines the importance of increased vigilance in the evaluation and treatment of pancreatitis in burned children.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Haidy G
authors.initials: HG
authors.lastname: Rivero
authors.forename: Jong O
authors.initials: JO
authors.lastname: Lee
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Mecott
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Kulp
authors.forename: Robert
authors.initials: R
authors.lastname: Kraft
authors.forename: Natasha C
authors.initials: NC
authors.lastname: Brooks
authors.forename: Manuel
authors.initials: M
authors.lastname: Diblidox-Gonzales
authors.forename: Hal K
authors.initials: HK
authors.lastname: Hawkins
authors.forename: Marc G
authors.initials: MG
authors.lastname: Jeschke
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000208:Acute Disease; D000293:Adolescent; D000681:Amylases / Q000032:analysis; D001344:Autopsy; D002056:Burns / Q000150:complications*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008049:Lipase / Q000032:analysis; D008297:Male; D010195:Pancreatitis / Q000201:enzymology / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D008049:Lipase; D000681:Amylases