title: Identifying botanical mechanisms of action.
abstract: The biological mechanism of action for any botanical extract is a necessary part of discovery to determine pharmacological use and safety. Interestingly, many activities that are governed by endogenous compounds are not fully understood making the characterization of mechanisms elusive. For example, phytoestrogens are being consumed for menopausal symptoms while the biological action of estradiol are still being investigated. Therefore, long term efficacy and safety issues are a challenge in the field. As new activities are associated with new biological pathways, an important component of therapeutic discovery will need to be the re-evaluation of negative or less active natural products to determine their relative use as medicines.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: May Fern
authors.initials: MF
authors.lastname: Toh
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Burdette
mesh_terms: D055808:Drug Discovery; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008593:Menopause; D048789:Phytoestrogens; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D048789:Phytoestrogens; D010936:Plant Extracts; D004958:Estradiol