title: Role of neoadjuvant chemotherapy in congenital intracranial haemangiopericytoma.
abstract: Infantile haemangiopericytoma of the CNS is a rare entity. We report the first case of a congenital haemangiopericytoma successfully treated by preoperative chemotherapy. The patient presented shortly after birth with the diagnosis of a haemangiopericytoma. As neurosurgery was too risky due to size, location and age of the patient an anthracycline-based chemotherapeutic regimen was applied and resulted in a significant decrease in tumour size, making a postchemotherapy complete surgical resection possible. Chemotherapy may benefit patients with congenital haemangiopericytoma especially if the tumour cannot initially be treated by complete neurosurgical resection.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.
authors.forename: Kornelius
authors.initials: K
authors.lastname: Kerl
authors.forename: Ronald
authors.initials: R
authors.lastname: Sträter
authors.forename: Martin
authors.initials: M
authors.lastname: Hasselblatt
authors.forename: Angela
authors.initials: A
authors.lastname: Brentrup
authors.forename: Michael C
authors.initials: MC
authors.lastname: Frühwald
mesh_terms: D018943:Anthracyclines / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000151:congenital / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006393:Hemangiopericytoma / Q000151:congenital / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D020360:Neoadjuvant Therapy / Q000379:methods*; D011300:Preoperative Care
chemical_list: D018943:Anthracyclines