Effect of BRAND's essence of chicken on the resetting process of circadian clocks in rats subjected to experimental jet lag.
BRAND's Essence of Chicken (BEC) has been widely used as a traditional remedy by people in Southeast Asia, which is proved to have an effect on the central nervous system (CNS) and autonomic nervous system (ANS). However, whether and how BEC consumption may affect mammalian circadian system is still largely unknown. In the present study, we investigated the effect of BEC feeding on the adaptation of circadian clocks to the experimental jet lag in rats. After the 12-h experimental jet lag through extending the light period, BEC feeding markedly facilitated the re-entrainment of all examined clock genes (Bmal1, Cry1, Per1, and Per2) in the pineal gland. The resetting time course of pineal clock genes was reduced from 7 days to only 3-5 days by BEC feeding, which was almost equal to the effect of melatonin feeding. In the liver clock, the facilitating effect of BEC feeding was mainly displayed in the re-entrainment of Bmal1 and Per2 by shortening their resetting processes for nearly 2 days. However, the resetting rate of locomotor activity rhythm was not affected by BEC feeding, suggesting that BEC might be unable to affect the behavioral rhythm.
Wu
Tao
T
College of Biological and Environmental Engineering, Zhejiang University of Technology, No 6 District Zhaohui, Zhejiang, 310032 Hangzhou, China.
Watanabe
Hiroshi
H
Hong
Lee Kian
LK
Abe
Keiichi
K
Ni
Yinhua
Y
Fu
Zhengwei
Z
D000818:Animals; D056926:CLOCK Proteins / Q000235:genetics / Q000378:metabolism; D002645:Chickens; D057906:Circadian Clocks / Q000187:drug effects*; D003624:Darkness; D005247:Feeding Behavior / Q000187:drug effects; D020179:Jet Lag Syndrome / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014020:Tissue Extracts / Q000008:administration & dosage / Q000494:pharmacology*
D014020:Tissue Extracts; D056926:CLOCK Proteins; D008550:Melatonin