Tandem synthesis of 2,3-dihydro-4-iminoquinolines via three-component alkyne-imine metathesis.
In the absence of any catalysts, ortho-alkynylanilines react with aldehydes and amines in HFIP to form trans-2,3-disubstituted 2,3-dihydro-4-iminoquinolines in a complete trans-selective manner via the three-component alkyne-imine metathesis.
Saito
Akio
A
Laboratory of Organic Reaction Chemistry, Showa PharmaceuticalUniversity, 3-3165 Higashi-Tamagawagakuen,Machida, Tokyo 194-8543, Japan. akio-sai@ac.shoyaku.ac.jp
Kasai
Jun
J
Konishi
Tomoyo
T
Hanzawa
Yuji
Y
D000480:Alkynes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000480:Alkynes; D007097:Imines; D011804:Quinolines