Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.
Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.
Biswas
Subhra K
SK
Singapore Immunology Network, Agency for Science, Technology & Research, Singapore. subhra_biswas@immunol.a-star.edu.sg
Mantovani
Alberto
A
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D009000:Monocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*
D016207:Cytokines