title: Synthetic studies on the mycolactone core.
abstract: Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.
authors.affiliation: Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
authors.forename: Kwang-Seuk
authors.initials: KS
authors.lastname: Ko
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Alexander
authors.forename: Shaun D
authors.initials: SD
authors.lastname: Fontaine
authors.forename: James E
authors.initials: JE
authors.lastname: Biggs-Houck
authors.forename: James J
authors.initials: JJ
authors.lastname: La Clair
authors.forename: Michael D
authors.initials: MD
authors.lastname: Burkart
mesh_terms: D000475:Alkenes; D001427:Bacterial Toxins / Q000138:chemical synthesis* / Q000737:chemistry*; D018942:Macrolides; D009161:Mycobacterium / Q000737:chemistry
chemical_list: D000475:Alkenes; D001427:Bacterial Toxins; D018942:Macrolides; C117218:mycolactone