title: Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand.
abstract: Consensus recommendations for managing chronic suppurative lung disease (CSLD) and bronchiectasis, based on systematic reviews, were developed for Australian and New Zealand children and adults during a multidisciplinary workshop. The diagnosis of bronchiectasis requires a high-resolution computed tomography scan of the chest. People with symptoms of bronchiectasis, but non-diagnostic scans, have CSLD, which may progress to radiological bronchiectasis. CSLD/bronchiectasis is suspected when chronic wet cough persists beyond 8 weeks. Initial assessment requires specialist expertise. Specialist referral is also required for children who have either two or more episodes of chronic (> 4 weeks) wet cough per year that respond to antibiotics, or chest radiographic abnormalities persisting for at least 6 weeks after appropriate therapy. Intensive treatment seeks to improve symptom control, reduce frequency of acute pulmonary exacerbations, preserve lung function, and maintain a good quality of life. Antibiotic selection for acute infective episodes is based on results of lower airway culture, local antibiotic susceptibility patterns, clinical severity and patient tolerance. Patients whose condition does not respond promptly or adequately to oral antibiotics are hospitalised for more intensive treatments, including intravenous antibiotics. Ongoing treatment requires regular and coordinated primary health care and specialist review, including monitoring for complications and comorbidities. Chest physiotherapy and regular exercise should be encouraged, nutrition optimised, environmental pollutants (including tobacco smoke) avoided, and vaccines administered according to national immunisation schedules. Individualised long-term use of oral or nebulised antibiotics, corticosteroids, bronchodilators and mucoactive agents may provide a benefit, but are not recommended routinely.
authors.affiliation: Royal Children's Hospital and Queensland Children's Medical Research Institute, Brisbane, QLD, Australia. annechang@ausdoctors.net
authors.forename: Anne B
authors.initials: AB
authors.lastname: Chang
authors.forename: Scott C
authors.initials: SC
authors.lastname: Bell
authors.forename: Cass A
authors.initials: CA
authors.lastname: Byrnes
authors.forename: Keith
authors.initials: K
authors.lastname: Grimwood
authors.forename: Peter W
authors.initials: PW
authors.lastname: Holmes
authors.forename: Paul T
authors.initials: PT
authors.lastname: King
authors.forename: John
authors.initials: J
authors.lastname: Kolbe
authors.forename: Louis I
authors.initials: LI
authors.lastname: Landau
authors.forename: Graeme P
authors.initials: GP
authors.lastname: Maguire
authors.forename: Malcolm I
authors.initials: MI
authors.lastname: McDonald
authors.forename: David W
authors.initials: DW
authors.lastname: Reid
authors.forename: Francis C
authors.initials: FC
authors.lastname: Thien
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Torzillo
mesh_terms: D000328:Adult; D001315:Australia; D001987:Bronchiectasis / Q000175:diagnosis* / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002648:Child; D002908:Chronic Disease; D018450:Disease Progression; D005100:Expectorants / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D009520:New Zealand; D011634:Public Health; D013492:Suppuration
chemical_list: D001993:Bronchodilator Agents; D005100:Expectorants; D005938:Glucocorticoids