title: The paraoxonase L55M and Q192R gene polymorphisms and myocardial infarction in a Tunisian population.
abstract: OBJECTIVE
  In the present study, we examined a possible association between the PON1 Q192R and L55M polymorphisms and myocardial infarction (MI) in a sample of the Tunisian population.
  
  
  METHODS
  Three hundred and ten patients with MI and 375 controls were recruited. Paraoxonase gene polymorphisms at codon 192 and 55 were analyzed by PCR-RFLP.
  
  
  RESULTS
  Genotype distributions and allele frequencies of L55M were similar among the control and MI groups. For the Q192R polymorphism patients with MI had significantly higher frequency of the RR genotype compared to controls [17.1% vs. 10.9%; OR (95% CI), 1.93 (1.24-3.02); p=0.004]. The MI patient group showed a significantly higher frequency of the R allele compared to the controls [38% vs. 30%; χ(2)=10.74, p=0.001]. The association between the PON1 Q192R polymorphism and MI remained significant after adjustment for other well-established cardiovascular risk factors.
  
  
  CONCLUSIONS
  The present study showed a significant and independent association between the PON1 Q192R polymorphism (presence of R allele) and MI in the Tunisian population.
authors.affiliation: Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia.
authors.forename: Amani
authors.initials: A
authors.lastname: Kallel
authors.forename: Yousra
authors.initials: Y
authors.lastname: Sediri
authors.forename: Mohamed Hédi
authors.initials: MH
authors.lastname: Sbaï
authors.forename: Mohamed Sami
authors.initials: MS
authors.lastname: Mourali
authors.forename: Moncef
authors.initials: M
authors.lastname: Feki
authors.forename: Monia
authors.initials: M
authors.lastname: Elasmi
authors.forename: Samah Haj
authors.initials: SH
authors.lastname: Taieb
authors.forename: Haïfa
authors.initials: H
authors.lastname: Sanhaji
authors.forename: Omar
authors.initials: O
authors.lastname: Souheil
authors.forename: Rachid
authors.initials: R
authors.lastname: Mechmeche
authors.forename: Riadh
authors.initials: R
authors.lastname: Jemaa
authors.forename: Naziha
authors.initials: N
authors.lastname: Kaabachi
mesh_terms: D000328:Adult; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human