title: Pathways of mammalian replication fork restart.
abstract: Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous recombination factors and the importance of DNA double-strand break formation.
authors.affiliation: University of Birmingham, UK. e.petermann@bham.ac.uk
authors.forename: Eva
authors.initials: E
authors.lastname: Petermann
authors.forename: Thomas
authors.initials: T
authors.lastname: Helleday
mesh_terms: D000818:Animals; D001816:Bloom Syndrome / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004249:DNA Damage; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D045566:DNA, Cruciform / Q000235:genetics; D006801:Humans; D008322:Mammals; D008957:Models, Genetic
chemical_list: D045566:DNA, Cruciform; D004247:DNA; D004265:DNA Helicases