title: Histoplasmosis presenting as a cutaneous malignancy of the eyelid.
abstract: Cutaneous histoplasmosis is an uncommon infection and can occur as a primary infection. A manifestation imitating a cutaneous neoplasm is rare, and eyelid involvement is rarer still. The authors report a case of histoplasmosis that presented as an ulcerated lesion on the lower eyelid margin that clinically resembled a basal cell carcinoma. Given its worldwide distribution, it is important to include this disease in the differential diagnosis of nonhealing eyelid lesions. Biopsy and tissue culture are paramount to establishing the diagnosis. This case describes a rare presentation of histoplasmosis on the eyelid and highlights the importance of histopathologic evaluation.
authors.affiliation: Department of Dermatology, University of California, Davis, California, USA.
authors.forename: Melissa Reyes
authors.initials: MR
authors.lastname: Merin
authors.forename: Maxwell A
authors.initials: MA
authors.lastname: Fung
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Eisen
authors.forename: Lily Koo
authors.initials: LK
authors.lastname: Lin
mesh_terms: D000368:Aged; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D017809:Fatal Outcome; D018023:HIV Seronegativity; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male
chemical_list: D017964:Itraconazole