title: Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.
abstract: New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.
authors.affiliation: Département de Chimie Moléculaire, UMR CNRS/UJF 5250, ICMG FR 2607, 570 rue de la chimie, BP 53, 38041 Grenoble cedex 9, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Galibert
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.forename: Didier
authors.initials: D
authors.lastname: Boturyn
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid