A case of methamphetamine use disorder treated with the antibiotic drug minocycline.
Methamphetamine (METH) use is one of the major public health concerns worldwide. Long-term use of METH induces not only dependence but also psychosis which is associated with METH-induced brain damage, including neuroinflammation produced by activated microglia. We report the case of a female patient whose psychotic symptoms in METH use disorder were successfully improved by anti-inflammatory drug minocycline therapy. Although the precise mechanism(s) underlying the efficacy of minocycline in METH use disorder are currently unclear, minocycline appears to be a good candidate for future investigation clinical trials for medication development in METH using populations.
Tanibuchi
Yuko
Y
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. aguadebeber11@yahoo.co.jp
Shimagami
Minoru
M
Fukami
Goro
G
Sekine
Yoshimoto
Y
Iyo
Masaomi
M
Hashimoto
Kenji
K
D000293:Adolescent; D019969:Amphetamine-Related Disorders / Q000150:complications / Q000534:rehabilitation*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D005260:Female; D006212:Hallucinations / Q000139:chemically induced / Q000534:rehabilitation; D006801:Humans; D008694:Methamphetamine / Q000633:toxicity; D008911:Minocycline / Q000627:therapeutic use*; D011594:Psychometrics; D011605:Psychoses, Substance-Induced / Q000534:rehabilitation*; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000534:rehabilitation*; D013375:Substance Withdrawal Syndrome / Q000534:rehabilitation
D000900:Anti-Bacterial Agents; D014150:Antipsychotic Agents; D008694:Methamphetamine; D008911:Minocycline