title: Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging.
abstract: Upconverting luminescent nanoparticles (UCNPs) display the unique property of emitting visible light following photoexcitation with near-infrared laser light. This results in features such as virtually zero autofluorescence of (biological) matter and easy separation of the emission peaks from stray light. Other features include rather narrow emission bands, very high chemical stability, the lack of bleaching, and the absence of blinking effects. This article reviews the work performed in the past few years with UCNPs in terms of surface modifications, bioconjugation, and optical (cellular) imaging.
authors.affiliation: Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040 Regensburg, Germany.
authors.forename: Heike S
authors.initials: HS
authors.lastname: Mader
authors.forename: Peter
authors.initials: P
authors.lastname: Kele
authors.forename: Sayed M
authors.initials: SM
authors.lastname: Saleh
authors.forename: Otto S
authors.initials: OS
authors.lastname: Wolfbeis
mesh_terms: D000818:Animals; D006801:Humans; D008027:Light; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry*; D057054:Molecular Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D049408:Luminescent Agents