title: An infrequent relapse of multiple myeloma predominantly manifesting as light chain escape: clinical experience from two Chinese centers.
abstract: Patients with intact immunoglobulin (Ig) multiple myeloma (MM) usually show parallel fluctuations of their intact Ig and light chain (LC) concentrations. Herein we report 11 patients with relapsed, intact Ig MM with a marked increase in urinary LCs in the absence of a parallel rise in serum intact Ig, known as light chain escape (LCE). A major feature accompanying the presentation of LCE was conversion of plasma cell morphology. An important feature preceding the onset of LCE was the use of biological therapies. These patients were not associated with a highly aggressive course. Median overall survival times after the diagnosis of MM and after LCE were 48 months and 24 months, respectively. These cases represent a documented series of a rare but clinically important mode. More attention should be directed toward patients with intact Ig MM when the clinical course deteriorates despite a reduction of intact monoclonal immunoglobins.
authors.affiliation: Department of Hematology, Changzheng Hospital, Second Hospital Affiliated to the Second Military Medical University, Shanghai, PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Qu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Weijun
authors.initials: W
authors.lastname: Fu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Xixi
authors.initials: X
authors.lastname: Xiang
authors.forename: Lugui
authors.initials: L
authors.lastname: Qiu
authors.forename: Jian
authors.initials: J
authors.lastname: Hou
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D010950:Plasma Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D012008:Recurrence; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D007147:Immunoglobulin Light Chains