Erectile dysfunction in living donor kidney transplant recipients associated with chronic hepatitis B infection.
OBJECTIVE
The objectives of this study were to investigate the prevalence of erectile dysfunction (ED) among living donor kidney transplant (LDKT) recipients associated with chronic hepatitis B infection in China and to assess the effect of successful LDKT to improve ED.


METHODS
From January 2006 to May 2009, erectile function of 26 LDKT recipients associated with chronic hepatitis B infection (Group 1) was evaluated predialysis, during dialysis, and at 6 months posttransplantation using the International Index of Erectile Function, version 5 (IIEF-5). We enrolled 61 age-matched LDKT recipients without hepatitis B/C infection as a control group (Group 2).


RESULTS
The prevalences of ED in Group 1 at predialysis, on dialysis, and 6 months posttransplantation were 23.1%, 80.7%, and 65.3%, respectively. Among Group 2, it was 4.9%, 72.1%, and 41.0%, respectively. The difference in ED between groups was significant at predialysis (P = .031) and 6 months posttransplantation (P = .037). Compared with the dialysis stage, the prevalence of ED at 6 months posttransplantation was significantly decreased in Group 2 (72.1% vs 41.0%; P = .001), but it was not significantly difference from Group 1 (80.7% vs 65.3%; P = .211).


CONCLUSIONS
The incidence of ED among hepatitis B recipients was higher than among hepatitis B/C-negative patients at the predialysis and posttransplantation stages. Kidney transplantation is a key treatment to reduce the prevalence of ED among hepatitis B/C-negative recipients, but not those with hepatitis B.
Guo
P
P
Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
Wang
Y
Y
Wang
L
L
Wang
J
J
D000328:Adult; D000714:Anastomosis, Surgical; D001835:Body Weight; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D007172:Erectile Dysfunction / Q000453:epidemiology* / Q000209:etiology; D019694:Hepatitis B, Chronic / Q000453:epidemiology*; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
D003404:Creatinine