Brain noise is task dependent and region specific.
The emerging organization of anatomical and functional connections during human brain development is thought to facilitate global integration of information. Recent empirical and computational studies have shown that this enhanced capacity for information processing enables a diversified dynamic repertoire that manifests in neural activity as irregularity and noise. However, transient functional networks unfold over multiple time, scales and the embedding of a particular region depends not only on development, but also on the manner in which sensory and cognitive systems are engaged. Here we show that noise is a facet of neural activity that is also sensitive to the task context and is highly region specific. Children (6-16 yr) and adults (20-41 yr) performed a one-back face recognition task with inverted and upright faces. Neuromagnetic activity was estimated at several hundred sources in the brain by applying a beamforming technique to the magnetoencephalogram (MEG). During development, neural activity became more variable across the whole brain, with most robust increases in medial parietal regions, such as the precuneus and posterior cingulate cortex. For young children and adults, activity evoked by upright faces was more variable and noisy compared with inverted faces, and this effect was reliable only in the right fusiform gyrus. These results are consistent with the notion that upright faces engender a variety of integrative neural computations, such as the relations among facial features and their holistic constitution. This study shows that transient changes in functional integration modulated by task demand are evident in the variability of regional neural activity.
Misić
Bratislav
B
Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada. bratislav.misic@utoronto.ca
Mills
Travis
T
Taylor
Margot J
MJ
McIntosh
Anthony R
AR
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D005145:Face; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D008297:Male; D009415:Nerve Net / Q000502:physiology; D009949:Orientation / Q000502:physiology; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology