title: Mechanical properties of the esophagus in eosinophilic esophagitis.
abstract: OBJECTIVE
  This study aimed to analyze the mechanical properties of the esophagus in eosinophilic esophagitis (EoE) using the functional luminal imaging probe (EndoFLIP; Crospon Medical Devices, Galway, Ireland).
  
  
  METHODS
  Thirty-three EoE patients (22 male; age range, 23-67 years) and 15 controls (6 male; age range, 21-68 years) were included. Subjects were evaluated during endoscopy with the EndoFLIP probe, comprised of a compliant cylindrical bag (maximal diameter 25 mm) with 16 impedance planimetry segments. Stepwise bag distensions from 2 to 40 mL were conducted and the associated intrabag pressure and intraluminal geometry were analyzed.
  
  
  RESULTS
  The EndoFLIP clearly displayed the tubular esophageal geometry and detected esophageal narrowing and localized strictures. Stepwise distension progressively opened the esophageal lumen until a distension plateau was reached such that the narrowest cross-sectional area (CSA) of the esophagus maximized despite further increases in intra-bag pressure. The esophageal distensibility (CSA vs pressure) was reduced in EoE patients (P = .02) with the distension plateau of EoE patients substantially lower than that of controls (median: CSA 267 mm(2) vs 438 mm(2); P < .01). Mucosal eosinophil count, age, sex, and current proton pump inhibitor treatment did not predict this limiting caliber of the esophagus (P ≥ 0.20).
  
  
  CONCLUSIONS
  Esophageal distensibility, defined by the change in the narrowest measurable CSA within the distal esophagus vs intraluminal pressure was significantly reduced in EoE patients compared with controls. Measuring esophageal distensibility may be an important adjunct to the management of EoE, as it is capable of providing an objective means to measure the outcomes of medical or dilation therapy.
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-2951, USA. monika.kwiatek@gmail.com
authors.forename: Monika A
authors.initials: MA
authors.lastname: Kwiatek
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hirano
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Kahrilas
authors.forename: Jami
authors.initials: J
authors.lastname: Rothe
authors.forename: Daniel
authors.initials: D
authors.lastname: Luger
authors.forename: John E
authors.initials: JE
authors.lastname: Pandolfino
mesh_terms: D000328:Adult; D000368:Aged; D002637:Chest Pain / Q000175:diagnosis / Q000503:physiopathology; D004106:Dilatation; D016099:Endoscopy, Gastrointestinal / Q000295:instrumentation / Q000379:methods; D057765:Eosinophilic Esophagitis / Q000503:physiopathology*; D004940:Esophageal Stenosis / Q000175:diagnosis; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D055595:Mechanical Phenomena; D008875:Middle Aged; D055815:Young Adult