Dopamine agonists and Othello's syndrome.
BACKGROUND
Othello's syndrome (OS) is a delusion of infidelity. We describe seven cases of OS in Parkinson's disease (iPD) patients using dopamine agonists.


METHODS
We searched the Mayo Clinic Medical Records System to identify all patients with OS. Clinical data abstracted include sex, age of onset of iPD, age of onset of OS, medications, effect of discontinuing the dopamine agonist, neuroimaging, and comorbidities.


RESULTS
Seven non-demented iPD patients with dopamine agonist implementation time locked to the development and resolution of OS are reported. The average age of iPD onset was 46.6 years (Standard deviation: 5.0 years), and OS onset was 53.7 years (7.1 years). All seven patients had significant marital conflict as a result of the delusions.


CONCLUSIONS
OS can be associated with dopamine agonist use and can lead to serious consequences. Dopamine agonist cessation eliminates the delusion of infidelity and should be the first treatment option.
Graff-Radford
Jonathan
J
Department of Neurology, Mayo Clinic, 200 1st Street SW Rochester, MN 55905, USA.
Ahlskog
J Eric
JE
Bower
James H
JH
Josephs
Keith A
KA
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects; D052160:Benzothiazoles / Q000009:adverse effects; D003702:Delusions / Q000139:chemically induced* / Q000523:psychology*; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005715:Gambling / Q000523:psychology; D006801:Humans; D008297:Male; D008393:Marriage; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D000077487:Pramipexole; D013577:Syndrome
D000978:Antiparkinson Agents; D052160:Benzothiazoles; D018491:Dopamine Agonists; D000077487:Pramipexole