Potential therapeutic applications of metal compounds directed towards hypoxic tissues.
Medicinal Inorganic Chemistry offers the high diversity of metal coordination chemistry for the development of bioactive compounds for therapeutic or diagnostic medicinal purposes. The design of novel metal-based antitumor agents occupies a privileged position in this discovery process. On the other hand, the research on metal-based radiopharmaceuticals for therapy and imaging is a subarea of high priority and development. This review describes therapeutic applications of metal compounds directed towards hypoxic tissues. Strategies in the search for new bioreductive metal-based prodrugs will be discussed. In addition, approaches for the imaging of hypoxic tissues by using metal radionuclides will be exemplified.
Gambino
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Cátedra de Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay. dgambino@fq.edu.uy
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D015687:Cell Hypoxia; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D008670:Metals / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use
D000970:Antineoplastic Agents; D003603:Cytotoxins; D008670:Metals; D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals