title: Metastatic neuroblastoma to the mandible: an unusual presentation.
abstract: Neuroblastoma is an uncommon cause of a mandibular mass. We describe an 8-month-old child who presented with loosening of his dentition, poor oral intake, and a large mandibular mass. Thorough radiographic study and subsequent biopsy of the oral lesion revealed the diagnoses of metastatic neuroblastoma. Ultimately, he was successfully treated with surgery and chemotherapy. The unusual presentation and pathophysiology of this malignancy will be reviewed. Neuroblastoma presenting as a mandible mass associated with natal teeth is rare, but it should be considered in the differential diagnosis of pediatric mandibular lesions.
authors.affiliation: University of Missouri-Columbia School of Medicine, Columbia, MO, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Parker
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Liess
authors.forename: Eliav
authors.initials: E
authors.lastname: Gov-Ari
authors.forename: Brett W
authors.initials: BW
authors.lastname: Sramek
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D014057:Tomography, X-Ray Computed