title: Eucophylline, a Tetracyclic Vinylquinoline Alkaloid from Leuconotis eugenifolius.
abstract: Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Deguchi
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Shoji
authors.forename: Alfarius E
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053961:Azabicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008296:Malaysia; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry
chemical_list: D000470:Alkaloids; D053961:Azabicyclo Compounds; D026121:Indole Alkaloids; C000603714:eucophylline; C543745:leucophyllidine; D052247:Nitric Oxide Synthase Type II