Intensive physical activity increases peripheral blood dendritic cells.
We analyzed the frequency and absolute numbers of circulating myeloid and plasmacytoid DCs in peripheral blood and evaluated their maturation status to test the hypothesis that significant physical stress to the body might induce measurable changes in DCs subsets, phenotype and function, which would complete existing knowledge about the response of the cellular immune system to an acute exercise in top sportsmen. We evaluated the heart rate and draw blood samples before and after the physical load in 18 profesional ice-hockey players. We observed an increase in leukocytes numbers with a predominant increase in the population of DCs and lymphocytes after exercise. Both myeloid and plasmacytoid DCs increased significantly. We found a correlation between the increase of peripheral blood DCs and serum epinephrine and norepinephrine levels. Increase in peripheral blood DCs also correlates with the extent of heart rate elevation during exercise.
Suchánek
Ondřej
O
Department of Immunology, Charles University, University Hospital Motol, Prague, Czech Republic.
Podrazil
Michal
M
Fischerová
Barbara
B
Bočínská
Helena
H
Budínský
Vít
V
Stejskal
David
D
Spíšek
Radek
R
Bartůňková
Jiřina
J
Kolář
Pavel
P
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology* / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006688:Hockey / Q000502:physiology*; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D009638:Norepinephrine / Q000097:blood
D015703:Antigens, CD; D009638:Norepinephrine; D004837:Epinephrine