Ovarian stimulation and the risk of aneuploid conceptions.
OBJECTIVE
To examine the rate of aneuploidy in missed abortions in patients who conceived after FSH ovarian stimulation compared with women who conceived in a natural cycle.


METHODS
Retrospective cohort.


METHODS
Academic reproductive endocrinology and infertility center.


METHODS
Women with karyotyping of products of conception (POC) from a missed abortion from January 1999 through August 2007. The rate of aneuploidy was compared between patients with a history of infertility who conceived naturally and patients with a history of infertility who conceived with FSH treatment.


METHODS
Ovarian stimulation with FSH, intrauterine insemination, and in vitro fertilization; genetic testing of POC after dilation and curettage.


METHODS
Embryonic karyotype.


RESULTS
A total of 229 pregnancies met inclusion criteria, and of these, 64% had an abnormal karyotype. The rate of aneuploidy was 63% in the study group and 70% in the control group. This difference was not statistically significant.


CONCLUSIONS
The incidence of embryonic aneuploidy was not higher in pregnancies conceived with FSH stimulation compared with spontaneous conceptions in infertility patients. This suggests that exogenous FSH exposure does not increase the risk of aneuploidy.
Massie
Jamie A M
JA
Stanford Fertility and Reproductive Medicine Center, Palo Alto, California 94304, USAiem1@stanford.edu
Shahine
Lora K
LK
Milki
Amin A
AA
Westphal
Lynn M
LM
Lathi
Ruth B
RB
D000030:Abortion, Missed / Q000453:epidemiology* / Q000601:surgery; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D015331:Cohort Studies; D004107:Dilatation and Curettage; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D005820:Genetic Testing / Q000706:statistics & numerical data; D006801:Humans; D007315:Insemination, Artificial / Q000706:statistics & numerical data*; D010062:Ovulation Induction / Q000379:methods / Q000706:statistics & numerical data*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors
D005640:Follicle Stimulating Hormone