title: Substructural hippocampal glucose metabolism observed on PET/MRI.
abstract: The hippocampus is one of the best-known neural structures in the brain and has been of interest in observing the substructures and their metabolic functions. However, it has been difficult to distinguish its substructures and functions in vivo because of its small size.
  
  
  METHODS
  (18)F-FDG PET and high-resolution MRI of the hippocampus were performed on 5 healthy subjects using a PET/MRI system. The metabolism of each hippocampal substructure was measured in vivo on the basis of the MR images.
  
  
  RESULTS
  The dentate gyrus and cornu ammonis 4 showed the highest glucose uptake in the healthy subjects.
  
  
  CONCLUSIONS
  Measuring glucose metabolism in the substructures of the hippocampus could provide a new tool for the future investigation of related brain diseases or functional studies, such as Alzheimer disease or memory and learning studies.
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-Gu, Incheon, South Korea. zcho@gachon.ac.kr
authors.forename: Zang-Hee
authors.initials: ZH
authors.lastname: Cho
authors.forename: Young-Don
authors.initials: YD
authors.lastname: Son
authors.forename: Hang-Keun
authors.initials: HK
authors.lastname: Kim
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Lee
authors.forename: Je-Geun
authors.initials: JG
authors.lastname: Chi
authors.forename: Chan-Woong
authors.initials: CW
authors.lastname: Park
authors.forename: Young-Bo
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism*; D006624:Hippocampus / Q000033:anatomy & histology* / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose