Influence of GABA-acting drugs on morphine-induced hyperthermia in rats.
A major inhibitory neurotransmitter of the nervous system, GABA (gamma-aminobutyric acid), is involved in mammalian thermoregulation. The present study investigated the influence of GABAergic neurotransmission-enhancing drugs, in a model of morphine-induced hyperthermia in conscious rats. We used body temperature assays to examine the effects of GABA-acting drugs on morphine-induced hyperthermia. In rats, low doses of morphine injected i.p. produced significant hyperthermia in a body temperature assay that was significantly attenuated upon pretreatment with GABA-acting drugs. These results suggest the existence of opioidergic-GABAergic interactions in a complex process of thermoregulation.
Nikolov
R
R
Department of Pharmacology and Toxicology, Medical University, Sofia, Bulgaria. ru_nikolov@abv.bg
D000701:Analgesics, Opioid / Q000633:toxicity; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D018682:GABA Agents / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009020:Morphine / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology; D020888:Vigabatrin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000701:Analgesics, Opioid; D018682:GABA Agents; D018757:GABA Modulators; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D009020:Morphine; D020888:Vigabatrin; D003975:Diazepam