Temporo-mesial extraventricular neurocytoma and cortical dysplasia in focal temporal lobe epilepsy.
We describe a 17-year-old boy with a left extraventricular temporo-mesial neurocytoma associated with cortical dysplasia causing focal pharmacoresistant temporal lobe epilepsy. He presented with a long history of medically refractory, temporal complex partial seizures. MRI showed a left temporo-mesial lesion suspect to be a low-grade tumor. Based on the pre-operative non-invasive neurophysiological studies, the patient underwent a left tailored temporal antero-mesial resection. Histopathological examination showed an extraventricular neurocytoma associated with architectural dysplasia (Type 1a) of the temporal pole. The patient was seizure-free at 2 years follow-up. Extraventricular neurocytomas must be considered in the differential diagnosis of the plethora of low-grade tumors associated with focal epilepsy that typically involve the temporal lobe, and are frequently associated with focal cortical dysplasia.
Giulioni
Marco
M
Division of Neurosurgery, Department of Neurosciences, Bellaria Hospital, Via Altura 3, Bologna 40139, Italy. giulioni.m@tiscali.it
Martinoni
Matteo
M
Rubboli
Guido
G
Marucci
Gianluca
G
Marliani
Anna Federica
AF
Battaglia
Stella
S
Badaloni
Filippo
F
Pozzati
Eugenio
E
Calbucci
Fabio
F
D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology / Q000601:surgery; D018306:Neurocytoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome