title: Healing effect of quince seed mucilage on T-2 toxin-induced dermal toxicity in rabbit.
abstract: This study was performed to examine the healing effects of creams prepared from quince seed mucilage on dermal toxicity induced by T-2 toxin. Creams were prepared from quince seed mucilage in eucerin base as 5, 10, and 15% (w/w). To induce dermal toxicity, 100 μg T-2 toxin was dissolved in 12 μl methanol and applied on the shaved skin of rabbit for 2 consecutive days. A separate group received only solvent (methanol). On the third day, the prepared creams were applied on the skin lesions twice a day until complete healing was occurred. Healing, was defined by decreased wound margin, treatment erythema and blisters. Time required for healing was 14, 14, 12, 10, and 9 days for groups of no treatment, eucerin, quince seed cream 5%, 10%, and 15%, respectively. Results obtained by this study shows that quince seed mucilage (15%) has more and better healing effects on dermal toxicity caused by T-2 toxin comparing to no treatment or eucerin cream without mucilage.
authors.affiliation: Dept. of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Hemmati
authors.forename: Hibatoallah
authors.initials: H
authors.lastname: Kalantari
authors.forename: Amir
authors.initials: A
authors.lastname: Jalali
authors.forename: Somie
authors.initials: S
authors.lastname: Rezai
authors.forename: Hossein Haghighi
authors.initials: HH
authors.lastname: Zadeh
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D008297:Male; D008517:Phytotherapy / Q000379:methods*; D011817:Rabbits; D027824:Rosaceae; D012639:Seeds; D012871:Skin Diseases / Q000139:chemically induced / Q000188:drug therapy*; D013605:T-2 Toxin / Q000633:toxicity*
chemical_list: D013605:T-2 Toxin