[Toxicogenomics in hazard assessment of chemicals].
Recent changes in the European legislation of chemicals suggest an urgent need for introduction of novel, alternative methods for testing chemical substances. Such possibility is offered by toxicogenomics--a scientific discipline combining knowledge from the field of toxicology, i.e., a science investigating the properties of toxic agents and the negative effects these agents exert on health and environment, with genomics, i.e., a science investigating the structure and function of genomes. New research strategies within the field of toxicology (transcriptomics, proteomics, metabolomics) offer conditions to assess the hazards associated with the effects of chemicals with both established and suspected toxic potentials.
Kostka
Grazyna
G
Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego-Państwowy Zakład Higieny, Warszawa. gkostka@pzh.gov.pl
Liszewska
Monika
M
Urbanek-Olejnik
Katarzyna
K
D054750:Ecotoxicology / Q000331:legislation & jurisprudence* / Q000458:organization & administration; D005060:Europe; D023281:Genomics / Q000331:legislation & jurisprudence; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D009930:Organic Chemicals / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity; D018570:Risk Assessment / Q000331:legislation & jurisprudence; D018675:Toxicity Tests / Q000379:methods*; D043922:Toxicogenetics / Q000331:legislation & jurisprudence* / Q000458:organization & administration
D015386:Hazardous Substances; D009930:Organic Chemicals; D010575:Pesticides