title: Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition.
abstract: A facile and highly efficient method for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles (β-keto 1,2,3-triazoles) in good to excellent yields from in-situ generated β-ketoazides and terminal alkynes through Cu(I) catalyzed 1,3 dipolar cycloaddition is described. This reaction proceeds smoothly either in water or in a 1:1 mixture of water and acetone at room temperature without use of any additive. The synthesized compounds were screened for their cytotoxicity in A549 (Lung Cancer), HT-29 (Colon Cancer), He La (Cervical Cancer) using MTT assay that exhibited significant cytotoxicity at modest doses.
authors.affiliation: Department of Chemistry, Nizam College, Osmania University, Hyderabad 500006, Andhra Pradesh, India.
authors.forename: Jyothi
authors.initials: J
authors.lastname: Vantikommu
authors.forename: Sadanandam
authors.initials: S
authors.lastname: Palle
authors.forename: Punganuru Surendra
authors.initials: PS
authors.lastname: Reddy
authors.forename: Vinodkumar
authors.initials: V
authors.lastname: Ramanatham
authors.forename: Mukkanti
authors.initials: M
authors.lastname: Khagga
authors.forename: Venkateswara Rao
authors.initials: VR
authors.lastname: Pallapothula
mesh_terms: D002384:Catalysis; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004353:Drug Evaluation, Preclinical; D006801:Humans; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D014230:Triazoles; D003300:Copper