Homing pathways of mesenchymal stromal cells (MSCs) and their role in clinical applications.
Mesenchymal stromal cells (MSCs) have come into focus for an increasing number of cellular therapies. Since most clinical protocols use intravenous application of MSCs, it has become important to understand their trafficking in the bloodstream. Moreover, since relatively little is known where the transplanted MSCs might locate, a better understanding of involved homing mechanisms will likely shed light on how MSCs exert their therapeutic effects. This review focuses on the current knowledge of homing pathways of transplanted MSCs. We describe regulatory signalling molecules and receptors involved. An outlook is given on significance of these findings for the future use of MSCs as a cellular therapeutic.
Deak
Erika
E
Stem Cell Biology Group, DRK Institute of Transfusion Medicine and Immune Hematology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Seifried
Erhard
E
Henschler
Reinhard
R
D000818:Animals; D002465:Cell Movement; D048091:Guided Tissue Regeneration; D006801:Humans; D056747:Immunomodulation; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D033581:Stem Cell Transplantation; D017154:Stromal Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D016201:Receptors, Lymphocyte Homing