Visuospatial perception and navigation in Parkinson's disease.
A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.
Young
Daniel E
DE
College of Health and Rehabilitation Sciences, Sargent College, Department of Psychology, Boston University, Boston, MA 02215, United States.
Wagenaar
Robert C
RC
Lin
Cheng-Chieh
CC
Chou
Ying-Hui
YH
Davidsdottir
Sigurros
S
Saltzman
Elliot
E
Cronin-Golomb
Alice
A
D000368:Aged; D001696:Biomechanical Phenomena; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D010468:Perceptual Disorders / Q000209:etiology* / Q000503:physiopathology; D010775:Photic Stimulation / Q000379:methods; D013028:Space Perception / Q000502:physiology*; D014584:User-Computer Interface; D016138:Walking