title: Anesthetics promoting in vitro AβPP metabolism and amyloid-β toxicity.
abstract: At present, more than 35 million people worldwide have Alzheimer's disease (AD). With increasing incidence and a growing number of aged patients undergoing surgery, the relevance of a possible interaction between anesthetics and AD is growing as well. Below, we review in vitro studies investigating the effects of anesthetics on the metabolism of amyloid precursor protein and its metabolite amyloid-β.
authors.affiliation: Klinik für Anästhesiologie, Technische Universität München, Germany. b.eckel@lrz.tum.de
authors.forename: Barbara
authors.initials: B
authors.lastname: Eckel
authors.forename: Manfred
authors.initials: M
authors.lastname: Blobner
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rammes
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000633:toxicity*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000777:Anesthetics / Q000009:adverse effects*; D000818:Animals; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000777:Anesthetics