title: IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.
abstract: The IgE-suppressive activity of (-)-matairesinol is demonstrated, and the structure-activity relationship of (-)-matairesinol clarified. 3',4-Dihydroxy-3,4'-dimethoxylignano-9,9'-lactone showed higher IgE-suppressive activity than (-)-matairesinol without any cytotoxic activity. Some derivatives bearing a longer and more bulky alkoxy group at the 3 or 4 position showed IgE-accelerative activity.
authors.affiliation: Faculty of Agriculture, Ehime University, Ehime, Japan.
authors.forename: Saya
authors.initials: S
authors.lastname: Kawahara
authors.forename: Ipei
authors.initials: I
authors.lastname: Iwata
authors.forename: Eriko
authors.initials: E
authors.lastname: Fujita
authors.forename: Manami
authors.initials: M
authors.lastname: Yamawaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nishiwaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugahara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Akiyama
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007073:Immunoglobulin E / Q000187:drug effects*; D007783:Lactones; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans; D007783:Lactones; D017705:Lignans; D007073:Immunoglobulin E; C068935:matairesinol