title: Reduced visual P300 amplitudes in individuals at ultra-high risk for psychosis and first-episode schizophrenia.
abstract: The purpose of this study was to investigate whether individuals at ultra-high risk (UHR) for psychosis and patients experiencing first-episode schizophrenia had impairments in visual information processing as indexed by the visual P300 event-related potential. Sixteen UHR individuals, 21 first-episode schizophrenia patients, and 16 healthy controls were included. Participants were asked to perform a visuospatial oddball task while undergoing an electroencephalogram. The UHR and first-episode groups showed reduced P300 amplitudes in comparison to healthy controls. P300 amplitudes were negatively correlated with severity of negative symptoms in both the UHR and first-episode groups. These results suggest that the visual P300 may be a neurobiological vulnerability marker, reflecting neurophysiological abnormalities associated with enduring negative symptoms in schizophrenia.
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, South Korea.
authors.forename: Su Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Kee
authors.initials: K
authors.lastname: Namkoong
authors.forename: Hye Hyun
authors.initials: HH
authors.lastname: Cho
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Song
authors.forename: Suk Kyoon
authors.initials: SK
authors.lastname: An
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods; D004198:Disease Susceptibility; D042241:Early Diagnosis; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000592:standards; D010775:Photic Stimulation / Q000379:methods; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology; D055815:Young Adult