title: During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat.
abstract: BACKGROUND
  Although serum TSH is often elevated in obesity and may be linked to disorders of lipid and glucose metabolism, the clinical relevance of these relationships remains unclear.
  
  
  METHODS
  Subjects were obese children and adolescents (n=206; mean age 14 yr) undergoing rapid weight and fat loss in a standardized, multidisciplinary, 2-month, in-patient weight loss program.
  
  
  METHODS
  This was a prospective study that determined thyroid function, glucose and lipid parameters, leptin, anthropometric measures, and body composition measured by dual-energy x-ray absorption at baseline and at the end of the intervention.
  
  
  RESULTS
  At baseline, 52% of children had TSH concentrations in the high normal range (>2.5 mU/liter), but TSH was not correlated with body weight, body mass index sd scores, lean body mass, or body fat percentage. At baseline, independent of adiposity, TSH significantly correlated with total cholesterol (P=0.008), low-density lipoprotein cholesterol (P=0.013), fasting insulin (P=0.010), homeostatic model assessment (HOMA) (P=0.004), and leptin (P=0.006). During the intervention, mean body fat, TSH, HOMA, and fasting insulin decreased by 21, 11, 53, and 54%, respectively. Change (Δ) in TSH did not correlate with Δbody weight or Δbody composition, but ΔTSH significantly correlated with, Δfasting insulin and ΔHOMA, independent of Δbody weight or Δbody composition (P<0.05).
  
  
  CONCLUSIONS
  TSH concentrations are elevated in obese children but are not correlated with the amount of excess body weight or fat. During weight loss, independent of changes in body weight or composition, decreases in elevated serum TSH predict decreases in fasting insulin and HOMA. These findings suggest interventions that target high TSH concentrations during weight loss in obese subjects may improve insulin sensitivity.
authors.affiliation: ETH Zürich, Human Nutrition Laboratory, Institute of Food Science and Nutrition, Schmelzbergstrasse 7, LFV D22, CH-8092 Zürich, Switzerland. isabelle.aeberli@ilw.agrl.ethz.ch
authors.forename: Isabelle
authors.initials: I
authors.lastname: Aeberli
authors.forename: Andreas
authors.initials: A
authors.lastname: Jung
authors.forename: Stefanie B
authors.initials: SB
authors.lastname: Murer
authors.forename: Johannes
authors.initials: J
authors.lastname: Wildhaber
authors.forename: Joanne
authors.initials: J
authors.lastname: Wildhaber-Brooks
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Knöpfli
authors.forename: Michael B
authors.initials: MB
authors.lastname: Zimmermann
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000628:therapy*; D018579:Patient Selection; D010809:Physical Fitness; D012016:Reference Values; D012044:Regression Analysis; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D015431:Weight Loss / Q000502:physiology*
chemical_list: D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine