It's not just sex.
The dosage of X and Y chromosome genes varies systematically in males and females. In mammals, X inactivation largely compensates for this, but in this issue of Developmental Cell, Wijchers et al. show that the expression of hundreds of autosomal genes is still influenced by sex chromosome dosage, independently of physiological sex.
Pirrotta
Vincenzo
V
Rutgers University, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. pirrotta@biology.rutgers.edu