title: HIV and bone loss.
abstract: The use of antiretroviral therapy has significantly reduced the number of deaths due to HIV/AIDS. However, no current therapy can suppress the virus completely, and as the HIV-infected population continues to live longer new complications are emerging from the persistence of the virus and use of antiretroviral therapy. This review summarizes the clinical evidence linking HIV-associated osteoporosis to direct infection and antiretroviral therapy (ART) use. The purported molecular mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/ART-related osteoporosis are given.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Shitij
authors.initials: S
authors.lastname: Arora
authors.forename: Manasi
authors.initials: M
authors.lastname: Agrawal
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Frantz
authors.initials: F
authors.lastname: Duffoo
authors.forename: Mone
authors.initials: M
authors.lastname: Zaidi
authors.forename: Jameel
authors.initials: J
authors.lastname: Iqbal
mesh_terms: D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology*; D015897:Comorbidity; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D015658:HIV Infections / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010024:Osteoporosis / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology*; D058866:Osteoporotic Fractures / Q000453:epidemiology / Q000503:physiopathology; D053245:RANK Ligand / Q000502:physiology; D018894:Reverse Transcriptase Inhibitors; D015398:Signal Transduction / Q000502:physiology
chemical_list: D044966:Anti-Retroviral Agents; D050659:Core Binding Factor Alpha 1 Subunit; D053245:RANK Ligand; C493709:RUNX2 protein, human; D018894:Reverse Transcriptase Inhibitors; C505688:TNFSF11 protein, human