Outcomes with the use of recombinant human erythropoietin in critically ill burn patients.
Recent data demonstrate a possible mortality benefit in traumatically injured patients when given subcutaneous recombinant human erythropoietin (rhEPO). The purpose of this report is to examine the effect of rhEPO on mortality and transfusion in burn patients. We conducted a review of burn patients (greater than 30% total body surface area, intensive care unit [ICU] days greater than 15) treated with 40,000 u rhEPO over an 18-month period (January 2007 to July 2008). Matched historical controls were identified and a contemporaneous cohort of subjects not administered rhEPO was used for comparison (NrhEPO). Mortality, transfusions, ICU and hospital length of stay were assessed. A total of 105 patients were treated (25 rhEPO, 53 historical control group, 27 NrhEPO). Hospital transfusions (mean 13,704 +/- mL vs. 13,308 +/- mL; P = 0.42) and mortality (29.6 vs. 32.0%; P = 0.64) were similar. NrhEPO required more blood transfusions (13,308 +/- mL vs. 6827 +/- mL; P = 0.004). No difference in mortality for the rhEPO and NrhEPO (32.0 vs. 22.2%; P = 0.43) was found. Thromboembolic complications were similar in all three groups. No effect was seen for rhEPO treatment on mortality or blood transfusion requirements in the severely burned.
Lundy
Jonathan B
JB
U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA. jlundy1313@yahoo.com
Hetz
Katherine
K
Chung
Kevin K
KK
Renz
Evan M
EM
White
Christopher E
CE
King
Booker T
BT
Huzar
Todd
T
Wolf
Steven E
SE
Blackbourne
Lorne H
LH
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D002056:Burns / Q000150:complications / Q000401:mortality / Q000628:therapy*; D016638:Critical Illness; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D055815:Young Adult
D011994:Recombinant Proteins; D004921:Erythropoietin