title: Pathological aspects of lipid peroxidation.
abstract: Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
authors.affiliation: INSERM I2MR-858, IFR-150, Avenue J Poulhès, BP 84225, Toulouse, France. anne.negre-salvayre@inserm.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Negre-Salvayre
authors.forename: Nathalie
authors.initials: N
authors.lastname: Auge
authors.forename: Victoria
authors.initials: V
authors.lastname: Ayala
authors.forename: Huveyda
authors.initials: H
authors.lastname: Basaga
authors.forename: Jordi
authors.initials: J
authors.lastname: Boada
authors.forename: Rainer
authors.initials: R
authors.lastname: Brenke
authors.forename: Sarah
authors.initials: S
authors.lastname: Chapple
authors.forename: Guy
authors.initials: G
authors.lastname: Cohen
authors.forename: Janos
authors.initials: J
authors.lastname: Feher
authors.forename: Tilman
authors.initials: T
authors.lastname: Grune
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lengyel
authors.forename: Giovanni E
authors.initials: GE
authors.lastname: Mann
authors.forename: Reinald
authors.initials: R
authors.lastname: Pamplona
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Poli
authors.forename: Manuel
authors.initials: M
authors.lastname: Portero-Otin
authors.forename: Yael
authors.initials: Y
authors.lastname: Riahi
authors.forename: Robert
authors.initials: R
authors.lastname: Salvayre
authors.forename: Shlomo
authors.initials: S
authors.lastname: Sasson
authors.forename: Jose
authors.initials: J
authors.lastname: Serrano
authors.forename: Ofer
authors.initials: O
authors.lastname: Shamni
authors.forename: Werner
authors.initials: W
authors.lastname: Siems
authors.forename: Richard C M
authors.initials: RC
authors.lastname: Siow
authors.forename: Ingrid
authors.initials: I
authors.lastname: Wiswedel
authors.forename: Kamelija
authors.initials: K
authors.lastname: Zarkovic
authors.forename: Neven
authors.initials: N
authors.lastname: Zarkovic
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008107:Liver Diseases / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology