title: Retroperitoneal solitary fibrous tumor-induced hypoglycemia associated with high molecular weight insulin-like growth factor II.
abstract: A man, aged 65 years, presented with frequent episodes of hypoglycemia and unconsciousness. Hypoglycemia was accompanied by undetectable serum insulin and C-peptide levels and a high serum insulin-like growth factor (IGF)-II level. He was found to have a retroperitoneal solitary fibrous tumor. He underwent successful resection of the tumor and had no hypoglycemic episodes after the operation. Immunohistochemical analysis revealed positive immunostaining for IGF-II in tumor cells. The presence of the high-molecular-weight form of IGF-II in the patient's serum was confirmed by immunoblotting, which suggests that his hypoglycemia was due to an increase in the plasma level of IGF-II secreted by the tumor.
authors.affiliation: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Yamakawa-Yokota
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ozaki
authors.forename: Akiko
authors.initials: A
authors.lastname: Okajima
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishio
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Oiso
mesh_terms: D000368:Aged; D002096:C-Peptide / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D007328:Insulin / Q000097:blood; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D011859:Radiography; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D014474:Unconsciousness / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D002096:C-Peptide; D007328:Insulin; D009363:Neoplasm Proteins; D007335:Insulin-Like Growth Factor II