Protective effects of Punica granatum in experimentally-induced gastric ulcers.
In the present investigation standardized aqueous methanolic extract of Punica (AMP) was used for its possible ulcer protective activity in wistar rats against different experimental models. Preliminary phytochemical screening of AMP reveals the presence of saponin, tannins, and flavonoids, which may be responsible for its activity. HPTLC finger prints of AMP showed the presence of 12 spots at different (retention factor) rf values. Oral administration of AMP (490 and 980 mg/kg bw) significantly reduced the ulcer lesion index produced by alcohol, indomethacin, and aspirin, at both doses in rats. Further, in pylorus-ligated rats AMP significantly reduces the ulcer lesions, gastric volume, and total acidity. It prevents the ulceration by increasing the pH and mucus secretion in pylorus ligated rats. The present study shows the anti-ulcer activity of AMP in experimentally-induced gastric ulcers.
Alam
Mohd Sarfaraz
MS
Department of Ilmul Advia, Faculty of Medicine, Jamia Hamdard, New Delhi - 110062, India.
Alam
Mohd Aftab
MA
Ahmad
Sayeed
S
Najmi
Abul Kalam
AK
Asif
Mohd
M
Jahangir
Tamanna
T
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D035264:Flowers; D007700:Kinetics; D029561:Lythraceae; D008297:Male; D010936:Plant Extracts / Q000378:metabolism; D020011:Protective Agents / Q000378:metabolism / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D020011:Protective Agents