title: Concise synthesis of Valerena-4,7(11)-diene, a highly active sedative, from valerenic acid.
abstract: A concise synthesis of valerena-4,7(11)-diene with potent sedative activity was achieved in three steps involving, reduction of carboxylic acid, bromination of the resulting alcohol, and reduction of the bromide from valerenic acid in a 63% total yield. This synthetic method makes it possible to provide further materials for biological testing to realize comprehensive SAR studies.
authors.affiliation: Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University, Nara, Japan. kitayama@nara.kindai.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Genki
authors.initials: G
authors.lastname: Kawabata
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
mesh_terms: D000475:Alkenes; D002264:Carboxylic Acids / Q000737:chemistry; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis*; D007192:Indenes / Q000138:chemical synthesis*; D008722:Methods; D055601:Organic Chemistry Phenomena; D012717:Sesquiterpenes / Q000138:chemical synthesis*
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D006993:Hypnotics and Sedatives; D007192:Indenes; D012717:Sesquiterpenes; C037133:valerenic acid