[Redistribution of gastrointestinal ammonia into blood in alcohol coma rat: the role in lethal outcome].
At 3 h after the intragastral administration of ethanol (446 mmol/kg) the blood ammonia concentration in v. portae increased 1.4 times, in v. cava inf. caudally of vv. renales inflow - 2.2 times, cranially of vv. hepaticae - 2.5 times, and in blood obtained by decapitation - by 65%7. The rate of ammonia accumulation in 'avage medium injected intraperitoneally was triple as that in intact rats. The exposure to atmospheric ammoniac (0.84-1.07 mg/l) for 3 h resuited in increasing blood ammonia concentration 2.4 times compared with the isolated ethanol action. The ammonia inhalation promoted the lethal action of ethanol with a dose alteration factor of 0.81 and suppressed gas-exchange. The promotion of the ethanol lethal action by the non-lethal ammonium acetate dosage has been observed. These data suggest that in rat, the coma-inducing ethanol ingestion promotes the translocation of intestinal ammonia into the common bloodstream, which has a detrimental effect on the outcome of alcohol coma.
Ivnitskiĭ
Iu Iu
IuIu
Shefer
T V
TV
Reĭniuk
V L
VL
D000435:Alcoholic Intoxication / Q000097:blood*; D000641:Ammonia / Q000097:blood*; D000818:Animals; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000494:pharmacology; D003128:Coma / Q000097:blood* / Q000139:chemically induced; D000431:Ethanol / Q000009:adverse effects* / Q000494:pharmacology; D041981:Gastrointestinal Tract / Q000378:metabolism*; D022124:Hyperammonemia / Q000097:blood* / Q000139:chemically induced; D008297:Male; D051381:Rats
D002492:Central Nervous System Depressants; D000431:Ethanol; D000641:Ammonia