[The effect of taurine derivative of change the biochemical parameters carbohidrate and lipide status by starvation].
The results obtained on the model of starvation shows that nutritional dropsy led to the significant decrease of glucose, total cholesterol (TCh) and triglycerides (TC), as well as increase of non-estherified fatty acids (NEFA) in blood serum. In the rats with nutritional dropsy after treatment fed with standard diet enriched with soybean protein body weight returned to normal values as well as levels of Glucose, TCh and TC. However, concentration of NEFA remained increased. In the experimental group received additionally taurepar or taurhythman the level of NEFA decreased up to the normal one. It is necessary to mention that taurine derivatives did not change the biochemical parameters in blood of normal non-starved rats. We suppose that these new substances promote reduction of intensity of hyperlipidemic processes. It is known, that during starvation incomplete oxidation of fatty acids leads to acidosis with following destruction of mitochondria membraine. Finding property of taurine derivatives to decrease the concentration of non-estherified fatty acids points at their ability for restoration of tricarboxilic acid's cycle and prevention of accumulation of suboxidized molecules of NEFA and acidosis development.
Khnychenko
L K
LK
Sapronov
N S
NS
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D004195:Disease Models, Animal; D005508:Food Deprivation; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051381:Rats; D013217:Starvation / Q000097:blood*; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology
D001786:Blood Glucose; C518136:taurepar; D013654:Taurine