Tissue regeneration potential in human umbilical cord blood.
Regenerative medicine is the process of creating functional tissue with the aid of stem cells, to repair loss of organ function. Possible targets for regenerative medicine include orthopaedic, cardiac, hepatic, pancreatic and central nervous system (CNS) applications. Umbilical cord blood (CB) has established itself as a legitimate source for haematopoietic stem cell transplantation. It is also considered an accessible and less immunogenic source for mesenchymal, unrestricted somatic and for other stem cells with pluri/multipotent properties. The latter are capable of differentiating into a wide variety of cell types including bone, cartilage, cardiomyocytes and neural. They also possess protective abilities that may contribute to tissue repair even if in vitro differentiation is excluded. In view of the absence of treatment for many devastating diseases, the elucidation of non-haematopoietic applications for CB will facilitate the development of pioneering relevant cell therapy approaches. This review focusses on current studies using human CB-derived cells for regenerative medicine.
Arien-Zakay
Hadar
H
Chaim Sheba Medical Center, Tel-Hashomer, Israel. hadara@ekmd.huji.ac.il
Lazarovici
Philip
P
Nagler
Arnon
A
D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods; D005312:Fetal Blood; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D009928:Organ Specificity; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods