Cooperative catalysis with metal and secondary amine: synthesis of 2-substituted quinolines via addition/cycloisomerization cascade.
A cooperative catalytic system, consisting of CuI and pyrrolidine, has been developed for an efficient synthesis of 2-substituted quinolines. A combination of both the catalysts is necessary; the use of either catalyst alone does not give the product.
Patil
Nitin T
NT
Organic Chemistry Division - II, Indian Institute of Chemical Technology, Hyderabad 500 607, India. nitin@iict.res.in
Raut
Vivek S
VS
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007454:Iodides; D011759:Pyrrolidines; D011804:Quinolines; D003300:Copper; C073870:cuprous iodide; C032519:pyrrolidine