title: Long-term outcome after drug-eluting stent implantation in comparison with bare metal stents: a single centre experience.
abstract: BACKGROUND
  The aim of our study was to evaluate the effect of drug-eluting stents (DES) compared with bare-metal stents (BMS) on all-cause mortality and target vessel revascularization (TVR) in a "real-world" clinical setting.
  
  
  RESULTS
  One thousand four hundred and ninety consecutive patients, who underwent PCI, were included in a prospective registry from January 2003 until December 2006. Patients were divided retrospectively into two groups: those who received a DES and those who received a BMS. The primary combined endpoint all-cause mortality or TVR and the individual endpoints death and TVR were evaluated during a mean follow-up period of 24.56 ± 12.5 months (range 6-52 months). In total 1,033 patients (69.3%) received BMS, while 457 patients (30.7%) received DES. With respect to clinical characteristics, significant differences between groups were found for age, hyperlipidemia, diabetes mellitus, heart failure, previous cerebral insult and presence of acute coronary syndrome (ACS) during intervention. Propensity score analysis was performed in attempt to eliminate this selection bias. With respect to the combined endpoint all-cause death or TVR, 12.9% of patients with DES and 21.3% with BMS (p = 0.015) had an event during the follow-up. 12.3% of patients with BMS but only 5.7% with DES died during the follow-up (p = 0.025). Thirty-three patients (7.2%) of the DES group and 99 patients (9.6%) of the BMS group (p = 0.1) needed TVR.
  
  
  CONCLUSIONS
  Our results obtained in a "real-world" clinical setting exhibit a clinical long-term benefit for DES compared with BMS and underline the safety and efficacy of DES over BMS.
authors.affiliation: 3rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Montleartstrasse 37, Vienna, Austria. i_tentzeris@gmx.net
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tentzeris
authors.forename: Rudolf
authors.initials: R
authors.lastname: Jarai
authors.forename: Serdar
authors.initials: S
authors.lastname: Farhan
authors.forename: Johann
authors.initials: J
authors.lastname: Wojta
authors.forename: Martin
authors.initials: M
authors.lastname: Schillinger
authors.forename: Alexander
authors.initials: A
authors.lastname: Geppert
authors.forename: Michael
authors.initials: M
authors.lastname: Nürnberg
authors.forename: Gerhard
authors.initials: G
authors.lastname: Unger
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000628:therapy; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods / Q000401:mortality*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D019233:Retreatment / Q000706:statistics & numerical data; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome