title: Cost of paid transplantation abroad: possible donor-origin early multiple myeloma in a renal transplant recipient treated using bortezomib.
abstract: The incidence of cancer is greater in transplant recipients compared with the general population. Posttransplantation lymphoproliferative disorder (PTLD) is the second most common cancer in these patients. Non-Hodgkin lymphoma is most commonly observed, and multiple myeloma (PTLD-MM) accounts for less than 4% of PTLDs. Most reported PTLD-MM is of recipient origin, and to date, few cases of donor-origin PTLD-MM have been reported. Bortezomib is a protease inhibitor that has been used successfully to treat multiple myeloma. Herein, we describe the case of a patient in whom multiple myeloma developed shortly after paid living-unrelated renal transplantation performed abroad (in Egypt). The patient had no apparent risk factors for PTLD-MM. Thus, it was supposed that PTLD-MM was of donor origin, considering its early development, lack of recipient risk factors, and no available donor medical status. To our knowledge, this report is the first to describe the use of bortezomib in this setting. Although bortezomib plus dexamethasone therapy resulted in hematologic remission, the patient remained dialysis-dependent.
authors.affiliation: Department of Nephrology, Selcuk University, Meram, Konya, Turkey. yalcinsolakmd@gmail.com
authors.forename: Y
authors.initials: Y
authors.lastname: Solak
authors.forename: H
authors.initials: H
authors.lastname: Atalay
authors.forename: M
authors.initials: M
authors.lastname: Anil
authors.forename: I
authors.initials: I
authors.lastname: Aydogdu
authors.forename: H Z
authors.initials: HZ
authors.lastname: Tonbul
mesh_terms: D004534:Egypt; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000191:economics* / Q000592:standards; D008232:Lymphoproliferative Disorders / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology*; D014019:Tissue Donors / Q000145:classification; D014180:Transplantation / Q000191:economics*