Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.
BACKGROUND
The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.


OBJECTIVE
The aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia.


METHODS
Plasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382 individuals without AIDS) were tested retrospectively for the presence of HBV sero-markers and for serum HBV DNA, screened for HCV infection by testing for anti-HCV antibody and HCV RNA.


RESULTS
HBsAg prevalence in HIV-positive individuals is 12.2%. HIV/HBV co-infected individuals with CD4 count of <200 cells µL⁻¹ have a higher HBV DNA viral load than patients with higher CD4 count (log 4.0 vs. log 2.0 DNA copies/ml, p < 0.05). Males (OR = 1.8, 95% CI: 1.0, 3.2) were more likely to be HBsAg positive than female. HCV seroprevalence was 0.9% in HIV-positive individuals.


CONCLUSIONS
The prevalence of HBsAg carriage in HIV- infected Gambians is similar to that obtained in the general population. However co-infected individuals with reduced CD4 levels, indicative of AIDS had higher prevalence of HBeAg retention and elevated HBV DNA levels compared to non-AIDS patients with higher CD4 count.
Jobarteh
Modou
M
Medical Research Council, Fajara, P O Box 273, Banjul, The Gambia.
Malfroy
Marine
M
Peterson
Ingrid
I
Jeng
Adam
A
Sarge-Njie
Ramu
R
Alabi
Abraham
A
Peterson
Kevin
K
Cotten
Matt
M
Hall
Andrew
A
Rowland-Jones
Sarah
S
Whittle
Hilton
H
Tedder
Richard
R
Jaye
Assan
A
Mendy
Maimuna
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005714:Gambia / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification; D015498:HIV-2 / Q000302:isolation & purification; D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D055815:Young Adult
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral