Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation.
The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl(4), BF(3)·Et(2)O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides.
Yao
Nianhuan
N
Division of Hematology and Oncology, Department of Internal Medicine, UC-Davis Cancer Center, School of Medicine, 4501 X Street, Sacramento, CA 95817, USA.
Fung
Gabriel
G
Malekan
Hamed
H
Ye
Long
L
Kurth
Mark J
MJ
Lam
Kit S
KS
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure
D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids