Three-component one-pot approach to synthesize benzopyrano[4,3-d]pyrimidines.
A novel benzopyrano[4,3-d]pyrimidine scaffold was generated via a three-component one-pot reaction from iodochromone, alkyne, and an amidine through a Sonogashira coupling, condensation, and cycloaddition. This combinatorial synthetic approach provides an efficient, easy construction of a diversified heterocyclic compounds library.
Li
Dewen
D
State Key Laboratory of Drug Research Shanghai Institute of Materia Medica,Chinese Academy of Science, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Duan
Shudong
S
Hu
Youhong
Y
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis
D011714:Pyrans; D011743:Pyrimidines; D054852:Small Molecule Libraries; C030986:pyrimidine