title: Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders.
abstract: Leonurus cardiaca L. (Lamiaceae) is used traditionally for its sedative, hypotensive and cardiotonic effects. Due to the lack of clinical data regarding its effect in patients, a study was carried out to assess the clinical efficacy of Leonurus oil extract (LOE) in patients with arterial hypertension stages 1 and 2, accompanied by anxiety and sleep disorders. Fifty patients were treated for 28 days with 1200 mg LOE per day. Positive effects of LOE on psycho-emotional status and arterial blood pressure in patients with stage 1 hypertension were observed 1 week earlier than in patients with stage 2 hypertension. According to the Clinical Global Impression (CGI) scale, a significant improvement in the symptoms of anxiety and depression was observed in 32% of patients, a moderate improvement in 48% and a weak effect in 8%; 12% of patients did not respond to therapy. Side effects were minimal in all groups. Leonurus oil extract may therefore be a potentially effective therapeutic agent for patients with arterial hypertension and concurrent psycho-neurological disorders.
authors.affiliation: Saint-Petersburg Institute of Pharmacy, 47/5, Piskarevsky pr., 195067, St Petersburg, Russia. alexs79@mail.ru
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Shikov
authors.forename: Olga N
authors.initials: ON
authors.lastname: Pozharitskaya
authors.forename: Valery G
authors.initials: VG
authors.lastname: Makarov
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Demchenko
authors.forename: Evgenia V
authors.initials: EV
authors.lastname: Shikh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D031332:Leonurus / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D010938:Plant Oils / Q000737:chemistry*; D012893:Sleep Wake Disorders / Q000150:complications*
chemical_list: D010936:Plant Extracts; D010938:Plant Oils