Acute thrombocytopenia: an unusual complication occurring after drug-eluting microspheres transcatheter hepatic chemoembolization.
Image-guided transcatheter hepatic chemoembolization (TACE) is accepted worldwide as an effective treatment for patients with unresectable hepatocellular carcinoma and liver metastases from neuroendocrine tumors, colorectal carcinomas, and uveal melanomas. Although the technique is relatively safe, it has been associated with several complications. We report the cases of two patients with colorectal liver metastases who developed acute thrombocytopenia a few hours after TACE. To our knowledge, acute thrombocytopenia occurring after TACE with drug-eluting microspheres has not yet been reported. Here we discuss the hypothetical etiopathogenetic mechanisms.
Poggi
Guido
G
Department of Oncology, IRCCS Fondazione S. Maugeri, Istituto Scientifico di Pavia, 27100 Pavia, Italy. guido.poggi@fsm.it
Quaretti
Pietro
P
Montagna
Benedetta
B
Sottotetti
Federico
F
Tagliaferri
Barbara
B
Pozzi
Emma
E
Amatu
Alessio
A
Pagella
Chiara
C
Bernardo
Giovanni
G
D000208:Acute Disease; D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D000077146:Irinotecan; D007958:Leukocyte Count; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D010976:Platelet Count; D012811:Sigmoid Neoplasms / Q000628:therapy*; D013921:Thrombocytopenia / Q000139:chemically induced*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000077146:Irinotecan; D002166:Camptothecin