title: Chemistry and biochemistry of lipid peroxidation products.
abstract: Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological states including inflammation, atherosclerosis, neurodegenerative diseases and cancer. This review is focused on recent advances concerning the formation, metabolism and reactivity towards macromolecules of lipid peroxidation breakdown products, some of which being considered as 'second messengers' of oxidative stress. This review relates also new advances regarding apoptosis induction, survival/proliferation processes and autophagy regulated by 4-hydroxynonenal, a major product of omega-6 fatty acid peroxidation, in relationship with detoxication mechanisms. The use of these lipid peroxidation products as oxidative stress/lipid peroxidation biomarkers is also addressed.
authors.affiliation: UMR1089 Xénobiotiques, INRA, Toulouse, France. fgueraud@toulouse.inra.fr
authors.forename: F
authors.initials: F
authors.lastname: Guéraud
authors.forename: M
authors.initials: M
authors.lastname: Atalay
authors.forename: N
authors.initials: N
authors.lastname: Bresgen
authors.forename: A
authors.initials: A
authors.lastname: Cipak
authors.forename: P M
authors.initials: PM
authors.lastname: Eckl
authors.forename: L
authors.initials: L
authors.lastname: Huc
authors.forename: I
authors.initials: I
authors.lastname: Jouanin
authors.forename: W
authors.initials: W
authors.lastname: Siems
authors.forename: K
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D000447:Aldehydes; D015415:Biomarkers; C027576:4-hydroxy-2-nonenal