Efficacy of a single dose hepatitis B depot vaccine.
A single dose formulation of a novel hepatitis B vaccine, consisting of an adjuvant emulsion of liposomes in oil was produced at a manufacturing scale and delivered to rabbits. This single dose vaccine generated a significantly higher antibody response than two doses of an alum-adjuvanted control vaccine in the short term, and was as effective as three doses of the control vaccine in the long term.
MacDonald
Lisa D
LD
ImmunoVaccine Technologies Inc., 1721 Lower Water St. Halifax, Nova Scotia, Canada.
Fuentes-Ortega
Antar
A
Sammatur
Leeladhar
L
Mansour
Marc
M
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D008081:Liposomes / Q000008:administration & dosage*; D011817:Rabbits
D000276:Adjuvants, Immunologic; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D008081:Liposomes