Antibiotic hypersensitivity in CF: drug-induced life-threatening hemolytic anemia in a pediatric patient.
Adverse reactions to antibiotics in patients with cystic fibrosis (CF) are a growing concern. We report the case of a pediatric patient with CF with multiple comorbidities and a history of drug reactions, who developed life-threatening piperacillin-induced immune hemolytic anemia. We review drug-induced hemolytic anemia (DIIHA) in particular, and antibiotic hypersensitivity in CF in general, including the frequency, pathogenesis, and risk factors. Finally, we discuss the treatment options and propose an algorithm for the management of drug-induced hypersensitivity reactions in patients with CF.
Chavez
Alma
A
Pulmonary Department, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, United States.
Mian
Amir
A
Scurlock
Amy M
AM
Blackall
Douglas
D
Com
Gulnur
G
D000293:Adolescent; D000465:Algorithms; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000453:epidemiology*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology*; D004342:Drug Hypersensitivity / Q000453:epidemiology; D005260:Female; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000453:epidemiology*; D012307:Risk Factors
D000900:Anti-Bacterial Agents