Liquiritigenin derivatives and their hepatotoprotective activity.
Liquiritigenin (7,4'-dihydroxyflavanone), isolated from the roots of Glycyrrhiza glabra, was derivatized to liquiritigenin 7, 4'-diacetate, liquiritigenin 4'-acetate, isoliquiritigenin, and liquiritigenin 7, 4'-dibenzoate. All these derivatives were evaluated for in vitro hepatoprotective activity against D-galactosamine-lipopolysaccharide(GalN/LPS) induced toxicity. In-vitro hepatotoxicity was manifested by a significant increase (P < 0.05) in liver toxicity biomarkers (SGPT, SGOT, ALKP, triglyceride, LPO, NO and LDH). The level of biomarkers in the treatment groups was significantly decreased (P < 0.05) when compared with the GalN/LPS group. The results revealed that isoliquiritigenin exhibited better hepatoprotective activity than liquiritigenin and its derivatives.
Gaur
Rashmi
R
Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
Kumar
Sunil
S
Trivedi
Priyanka
P
Bhakuni
Rajendra Singh
RS
Bawankule
Dnyaneshwar Umrao
DU
Pal
Anirban
A
Shanker
Karuna
K
D000818:Animals; D002478:Cells, Cultured; D047188:Chalcones / Q000494:pharmacology*; D019610:Cytoprotection; D044950:Flavanones / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D005688:Galactosamine / Q000633:toxicity; D006035:Glycyrrhiza / Q000737:chemistry*; D022781:Hepatocytes / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D047188:Chalcones; D044950:Flavanones; D005419:Flavonoids; D005688:Galactosamine; C040920:isoliquiritigenin; C083152:liquiritigenin