Volume changes of corpus striatum, thalamus, hippocampus and lateral ventricles in posttraumatic stress disorder (PTSD) patients suffering from headaches and without therapy.
OBJECTIVE
In the present study, we have hypothesized that volume changes of the caudate nucleus, putamen, globus pallidus, hippocampus, thalamus, and lateral ventricle in newly-diagnosed, male PTSD patients without therapy are more pronounced in those with headaches. To confirm or reject our hypothesis, we have undertaken an extensive study of forty-nine PTSD patients.


METHODS
To confirm or reject our hypothesis, we have undertaken an extensive study of forty-nine PTSD male patients that underwent MRI scanning immediately upon admittance for the treatment. Based on headache frequency, they were classified into three groups: group 1 included patients with headaches at least twice a week; group 2 consisted of patients with headaches less than twice a week; and group 3 consisted of patients without headaches. All MRI scans underwent software-based volume compute and statistical processing.


RESULTS
39 out of 49 patients with PTSD suffered from headaches. Bilaterally, volume decreases were noted in groups 1 and 2 compared to group 3 for the caudate nucleus, putamen, hippocampus and lateral ventricle. Differences in globus pallidus and thalamus among groups appeared to be insignificant.


CONCLUSIONS
The present study revealed a bilateral volume decrease of the caudate nucleus, putamen and hippocampus in PTSD male subjects without therapy. Intensity of volume alterations correlated with Hamilton's depression rating score; regression analysis uncovered correlated changes in the caudate nucleus, putamen and hippocampus, and an inverse correlation with the volume of the lateral ventricle in the PTSD patients.
Filipovic
B R
BR
School of Medicne in Belgrade, Institute of Anatomy Belgrade, Serbia.
Djurovic
B
B
Marinkovic
S
S
Stijak
L
L
Aksic
M
M
Nikolic
V
V
Starcevic
A
A
Radonjic
V
V
D000328:Adult; D003342:Corpus Striatum / Q000473:pathology*; D003863:Depression / Q000523:psychology; D005917:Globus Pallidus / Q000473:pathology; D006261:Headache / Q000209:etiology / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D038801:International Classification of Diseases; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D011699:Putamen / Q000473:pathology; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D013788:Thalamus / Q000473:pathology*