title: Chemical constituents of Osyris alba and their antiparasitic activities.
abstract: Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis. Osyrisine, catechin, and catechin-3-O-α-L-rhamnopyranoside exhibited a significant level of antiparasitic activity against two parasites, Entamoeba histolytica and Giardia intestinalis.
authors.affiliation: Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan.
authors.forename: Hala I
authors.initials: HI
authors.lastname: Al-Jaber
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: Mosleh
authors.forename: Abdallah
authors.initials: A
authors.lastname: Mallouh
authors.forename: Omar M
authors.initials: OM
authors.lastname: Abu Salim
authors.forename: Musa H
authors.initials: MH
authors.lastname: Abu Zarga
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002392:Catechin / Q000737:chemistry; D002522:Chlorocebus aethiops; D004748:Entamoeba histolytica / Q000187:drug effects*; D016829:Giardia lamblia / Q000187:drug effects*; D007597:Jordan; D008795:Metronidazole / Q000494:pharmacology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029630:Santalaceae / Q000737:chemistry*; D013237:Stereoisomerism; D014709:Vero Cells
chemical_list: D000977:Antiparasitic Agents; D011763:Pyrrolizidine Alkaloids; C552796:osyrisine; D008795:Metronidazole; D002392:Catechin