title: Concomitant adenocarcinoma and colonic non-Hodgkin's lymphoma in a patient with ulcerative colitis: a case report and molecular analysis.
abstract: Ulcerative colitis (UC) complicated by colonic lymphoma is rare, although UC is often accompanied by adenocarcinoma of the colon. A concurrent existence of adenocarcinoma and lymphoma in a patient with UC is extremely rare, and has not yet been analyzed at the molecular level. We report a 64-year-old female patient with concomitant adenocarcinoma and diffuse large B-cell lymphoma (DLBCL) in the colon of UC. The genetic changes in these two neoplasms were analyzed. The colon adenocarcinomas had a mutation in MSH6 gene, DNA methylation in CDKN2A gene, and increased microsatellite instability (MSI), although these genetic changes were not recognized in either DLBCL or non-neoplastic UC mucosa. The DLBCL was diagnosed as primary colonic lymphoma, and confirmed Epstein-Barr virus (EBV) infection. The adenocarcinomas and the non-neoplastic UC mucosa were EBV-negative. Our case presented here clearly shows that the development of adenocarcinoma and lymphoma in the colon with UC was caused by individual mechanisms.
authors.affiliation: Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishigami
authors.forename: Tatsuki R
authors.initials: TR
authors.lastname: Kataoka
authors.forename: Ikuko
authors.initials: I
authors.lastname: Torii
authors.forename: Ayuko
authors.initials: A
authors.lastname: Sato
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirano
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hida
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Tsujimura
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics / Q000473:pathology*; D003110:Colonic Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins / Q000235:genetics*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D019942:Genes, p16; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000821:virology*; D053842:Microsatellite Instability; D008875:Middle Aged; D009154:Mutation; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D011239:Prednisolone