title: [Results of surgical resection for patients with pulmonary cryptococcosis].
abstract: Pulmonary cryptococcosis is a fungal infection caused by inhalation of Cryptococcus neoformans. Pulmonary cryptococcal infections tend to occur in immunocompromised individuals, although they can occasionally develop even in immunocompetent hosts. This report presents a retrospective clinical study of 8 patients who underwent a surgical resection for pulmonary cryptococcosis between 1999 and 2008. The age of the patients ranged from 49 to 85 years old (mean 62.6). There were 4 male and 4 female patients. All patients except for 1 had no symptoms. Two patients were immuno-compromised hosts undergoing corticosteroid therapy due to myasthenia gravis and rheumatoid arthritis, respectively. There were 7 patients with a single nodule and 1 patient with multiple nodules. The tumors ranged from 9 to 21 mm in diameter. None of the patients were definitely diagnosed prior to the surgical resection. The surgical procedures included 5 partial resections, 1 segmentectomy and 2 lobectomies. It is often difficult to make a differential diagnosis between lung cancer and pulmonary cyptococosis, because pulmonary cyptococosis shows similar imaging findings in CT. Therefore, a surgical resection is recommended if an observation of the pulmonary nodes is required to make a differential diagnosis of malignant tumors. All of the patients in the current series showed a good outcome without any relapse including cryptococcal meningitis after a surgical resection.
authors.affiliation: Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Takenaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanagiri
authors.forename: Sohichi
authors.initials: S
authors.lastname: Oka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Baba
authors.forename: Manabu
authors.initials: M
authors.lastname: Yasuda
authors.forename: Kenji
authors.initials: K
authors.lastname: Ono
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Uramoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: So
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takenoyama
authors.forename: Sohsuke
authors.initials: S
authors.lastname: Yamada
authors.forename: Kosei
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003453:Cryptococcosis / Q000473:pathology / Q000601:surgery*; D003455:Cryptococcus neoformans; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D012189:Retrospective Studies; D016896:Treatment Outcome