title: The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy korean male adults.
abstract: BACKGROUND
  We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.
  
  
  METHODS
  Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed.
  
  
  RESULTS
  Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors.
  
  
  CONCLUSIONS
  A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Chan-Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Ji-Cheol
authors.initials: JC
authors.lastname: Bae
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Yoo
authors.forename: Won-Jun
authors.initials: WJ
authors.lastname: Kim
authors.forename: Cheol-Young
authors.initials: CY
authors.lastname: Park
authors.forename: Ji Oh
authors.initials: JO
authors.lastname: Mok
authors.forename: Chul Hee
authors.initials: CH
authors.lastname: Kim
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Ki-Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Sung-Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sun-Woo
authors.initials: SW
authors.lastname: Kim