Effect of accessions of Colocasia esculenta-based diets on the hepatic and renal functional indices of weanling Wistar rats.
The liver and kidney functional indices of weanling albino rats (Rattus norvegicus) maintained on different accessions (offspring of a variety planted/collected at a specific location and time but differing in certain morphological characteristics) of cooked Colocasia esculenta (cocoyam)-based diets (UFCe1-UFCe7) for 28 days were investigated. All the accessions of C. esculenta-based diets did not significantly (P > .05) alter the serum levels of albumin, globulin, inorganic phosphorus, calcium, magnesium, and uric acid of the animals.The total protein and total bilirubin levels decreased only in the UFCe3- and UFCe4-fed animals, respectively. Whereas UFCe1 and UFCe2 significantly decreased the conjugated bilirubin levels, UFCe3 and UFCe6 increased it. While all the accessions of C. esculenta-based diet decreased the serum alkaline phosphatase activity, γ-glutamyl transferase activity was increased. UFCe1 and UFCe5 increased the serum alanine aminotransferase activity, whereas UFCe4 decreased the activity of the enzyme. Again, UFCe3 and UFCe1 increased the serum creatinine and aspartate aminotransferase activity of the animals. Furthermore, the computed blood urea nitrogen:creatinine ratio was higher in animals maintained on UFCe1-, UFCe3-, UFCe4-, and UFCe5-based diets. Whereas UFCe6 and UFCe7 increased the level of sodium in the serum of the animals, UFCe4 and UFCe5 decreased the chloride level. The serum urea level was decreased by UFCe1, UFCe3, UFCe4, and UFCe5, whereas the potassium level increased in the UFCe4-, UFCe6-, and UFCe7-fed animals. Overall, the results revealed that all the accessions of C. esculenta produced selective effects on the hepatic and renal functional indices of the weanling rats. The highest alterations were produced by UFCe4, whereas the least was from UFCe2. These alterations may have consequential effects on the normal functioning of the liver and kidney of the animals. UFCe2 exhibited the least toxicity risk among the accessions of C. esculenta growing in the KwaZulu-Natal Province of South Africa.
Lewu
Muinat N
MN
Department of Botany, University of Fort Hare, Alice, South Africa.
Yakubu
Musa T
MT
Adebola
Patrick O
PO
Afolayan
Anthony J
AJ
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D031060:Colocasia / Q000633:toxicity*; D004032:Diet; D005260:Female; D006358:Hot Temperature; D007674:Kidney Diseases / Q000209:etiology*; D007677:Kidney Function Tests; D008107:Liver Diseases / Q000209:etiology*; D008111:Liver Function Tests; D008297:Male; D035281:Plant Tubers / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D014886:Weaning; D005723:gamma-Glutamyltransferase / Q000097:blood
D001798:Blood Proteins; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D001663:Bilirubin