title: Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium-catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation.
abstract: A strategy involving palladium-catalyzed cyclization of halo-phenyl hydrazones and aryl isocyanates provides a convenient approach to the synthesis of 1,3,4-benzotriazepines (4) or 1-arylamide-1H-indazoles (5) in good isolated yields. Microwave irradiation was found to afford high reaction efficiency, while the choice of halophenyl hydrazone had an effect on the pathway of the reaction.
authors.affiliation: College of Pharmacy, State Key Laboratory of Virology, Wuhan University, Wuhan, 430071, China. cdong@whu.edu.cn
authors.forename: Chune
authors.initials: C
authors.lastname: Dong
authors.forename: Lingli
authors.initials: L
authors.lastname: Xie
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Mou
authors.forename: Yashan
authors.initials: Y
authors.lastname: Zhong
authors.forename: Wei
authors.initials: W
authors.lastname: Su
mesh_terms: D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D017953:Isocyanates / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves; D010165:Palladium / Q000737:chemistry*
chemical_list: D001552:Benzazepines; D006835:Hydrazones; D007191:Indazoles; D017953:Isocyanates; D010165:Palladium