title: Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals.
abstract: The present study compared the effects of anesthesia induction with sevoflurane and propofol on hemodynamics, P-wave dispersion (Pwd), QT interval and corrected QT (QTc) interval. A total of 72 adult patients were included in this prospective study. All patients had control electrocardiograms (ECGs) before anesthesia induction. Anesthesia was induced with sevoflurane inhalation or intravenous propofol. Electrocardiography for all patients was performed during the 1(st) and 3(rd) minutes of induction, 3 minutes after administration of muscle relaxant, and at 5 minutes and 10 minutes after intubation. Pwd and QT intervals were measured on all ECGs. QTc intervals were determined using the Bazett formula. There was no significant difference in Pwd and QT and QTc intervals on control ECGs. In the sevoflurane group, except for control ECGs, Pwd and QTc interval on all ECGs were significantly longer than those in the propofol group (p < 0.05). We conclude that propofol should be used for anesthesia induction in patients with a predisposition to preoperative arrhythmias, and in those whose Pwd and QTc durations are prolonged on preoperative ECGs.
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Zonguldak Karaelmas University, Turkey. vhanci@gmail.com
authors.forename: Volkan
authors.initials: V
authors.lastname: Hanci
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydin
authors.forename: Bülent Serhan
authors.initials: BS
authors.lastname: Yurtlu
authors.forename: Hilal
authors.initials: H
authors.lastname: Ayoğlu
authors.forename: Rahsan Dilek
authors.initials: RD
authors.lastname: Okyay
authors.forename: Ebru
authors.initials: E
authors.lastname: Taş
authors.forename: Gülay
authors.initials: G
authors.lastname: Erdoğan
authors.forename: Keziban
authors.initials: K
authors.lastname: Aydoğan
authors.forename: Isil Ozkoçak
authors.initials: IO
authors.lastname: Turan
mesh_terms: D000293:Adolescent; D000328:Adult; D000777:Anesthetics / Q000008:administration & dosage* / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D000777:Anesthetics; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol