title: 3-hydroxy 3-methylglutaryl coenzyme A reductase: a new biomarker of fish exposure to water pollution.
abstract: The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor α, biomarkers of pollution exposure and lowered O₂, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O₂ content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.
authors.affiliation: Department of Biology, University of Roma Tre, Italy. vpallott@uniroma3.it
authors.forename: Valentina
authors.initials: V
authors.lastname: Pallottini
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Scalici
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Gibertini
authors.forename: Maria
authors.initials: M
authors.lastname: Marino
authors.forename: Anna
authors.initials: A
authors.lastname: Trentalance
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005399:Fishes / Q000378:metabolism*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D008297:Male; D014873:Water Pollutants / Q000633:toxicity*; D014876:Water Pollution / Q000032:analysis / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers; D014873:Water Pollutants; D006903:Hydroxymethylglutaryl CoA Reductases