Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract.
In the present study six probiotic Lactobacillus rhamnosus strains were investigated for their ability to survive in the human upper gastrointestinal tract through a dynamic gastric model of digestion. MRS broth was used as delivery vehicle and survival was investigated during in vitro gastric and gastric plus duodenal digestion. Results highlighted that all tested strains showed good survival rate during both gastric and duodenal digestion. In particular, three strains exhibited a great survival showing a recovery percentage in the range between 117 and 276%. In agreement with survival data, high lactic acid production was detected for all strains, confirming their metabolic activity during digestion.
Pitino
Iole
I
DOFATA, Dipartimento di Orto Floro Arboricoltura e Tecnologie Agro-alimentari, University of Catania, Catania, Italy.
Randazzo
Cinzia Lucia
CL
Mandalari
Giuseppina
G
Lo Curto
Alberto
A
Faulks
Richard Martin
RM
Le Marc
Yvan
Y
Bisignano
Carlo
C
Caggia
Cinzia
C
Wickham
Martin Sean John
MS
D004063:Digestion; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D052201:Lacticaseibacillus rhamnosus / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism; D050296:Microbial Viability; D008954:Models, Biological; D041742:Upper Gastrointestinal Tract / Q000382:microbiology*
D019344:Lactic Acid