Surface modification of polyimide sheets for regenerative medicine applications.
In the present work, two strategies were elaborated to surface-functionalize implantable polyimide sheets. In the first methodology, cross-linkable vinyl groups were introduced on the polyimide surface using aminopropylmethacrylamide. In the second approach, a reactive succinimidyl ester was introduced on the surface of PI. Using the former approach, the aim is to apply a vinyl functionalized biopolymer coating. In the latter approach, any amine containing biopolymer can be immobilized. The foils developed were characterized in depth using a variety of characterization techniques including atomic force microscopy, static contact angle measurements, and X-ray photoelectron spectroscopy. The results indicated that both modification strategies were successful. The subcutaneous implantation in mice indicated that both modification strategies resulted in biocompatible materials, inducing only limited cellular infiltration to the surrounding tissue.
Van Vlierberghe
S
S
Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281 S4-bis, Ghent, Belgium,
Sirova
M
M
Rossmann
P
P
Thielecke
H
H
Boterberg
V
V
Rihova
B
B
Schacht
E
E
Dubruel
P
P
D000178:Acrylamides / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D016207:Cytokines / Q000097:blood; D005260:Female; D020007:Implants, Experimental / Q000009:adverse effects; D008297:Male; D055595:Mechanical Phenomena; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D056951:Photoelectron Spectroscopy; D044968:Regenerative Medicine; D012117:Resins, Synthetic / Q000009:adverse effects / Q000737:chemistry*; D013499:Surface Properties
D000178:Acrylamides; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D016207:Cytokines; D012117:Resins, Synthetic; C029945:polyimide resin; C045985:methacrylamide