title: Tandem synthesis of 2,3-dihydro-4-iminoquinolines via three-component alkyne-imine metathesis.
abstract: In the absence of any catalysts, ortho-alkynylanilines react with aldehydes and amines in HFIP to form trans-2,3-disubstituted 2,3-dihydro-4-iminoquinolines in a complete trans-selective manner via the three-component alkyne-imine metathesis.
authors.affiliation: Laboratory of Organic Reaction Chemistry, Showa PharmaceuticalUniversity, 3-3165 Higashi-Tamagawagakuen,Machida, Tokyo 194-8543, Japan. akio-sai@ac.shoyaku.ac.jp
authors.forename: Akio
authors.initials: A
authors.lastname: Saito
authors.forename: Jun
authors.initials: J
authors.lastname: Kasai
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Konishi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hanzawa
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007097:Imines; D011804:Quinolines