[Levosulpiride in the management of functional dyspepsia and delayed gastric emptying].
Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect. At a dosage of 25mg three times daily, levosulpiride accelerates gastric and gallbladder emptying. Clinical trials have shown that this agent is more effective than placebo in reducing the symptoms of dyspepsia, while comparative studies have demonstrated that its effect is similar or superior to that of other dopamine antagonists. The safety profile of levosulpiride is good and the frequency of adverse events is similar to that of other D(2) dopamine antagonists. Therefore, this drug is a useful therapeutic option in the management of patients with functional dyspepsia, as well as in those with delayed gastric emptying.
Serra
Jordi
J
Servicio de Digestivo, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
D000818:Animals; D002986:Clinical Trials as Topic; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D065127:Dopamine D2 Receptor Antagonists; D004353:Drug Evaluation, Preclinical; D004415:Dyspepsia / Q000188:drug therapy*; D016473:Gallbladder Emptying / Q000187:drug effects; D005746:Gastric Emptying / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018589:Gastroparesis / Q000188:drug therapy*; D006168:Guinea Pigs; D006801:Humans; D015394:Molecular Structure; D058828:Serotonin 5-HT4 Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D005765:Gastrointestinal Agents; D058828:Serotonin 5-HT4 Receptor Agonists; D013469:Sulpiride; C078143:levosulpiride