title: Update on fungal keratitis from 1999 to 2008.
abstract: OBJECTIVE
  To report trends in fungal keratitis from a single institution between 1999 and 2008.
  
  
  METHODS
  Retrospective chart review of the patients presenting to the cornea service with fungal keratitis from April 1999 to December 2008.
  
  
  RESULTS
  Seventy-eight eyes of 76 patients were identified. The most common predisposing factors included contact lens use (35.9%), trauma (21.8%), and history of penetrating keratoplasty (15.4%). There was a significant increase in the rate of contact lens-related Fusarium infections over time, which peaked in 2005 and 2006 (P = 0.021). Almost 40% of fungal keratitis cases [11 of 28 eyes (39.3%)] were soft contact lens-related Fusarium infections in 2005 and 2006, and this decreased to less than 10% [2 of 25 eyes (8%)] in 2007 and 2008. The odds of having a contact lens-related Fusarium infection in 2005-2006 compared with 2007-2008 was 4.40 (95% confidence interval of 0.60-32.50) (P = 0.178). Despite the decrease in contact lens-related Fusarium infections, the number of fungal infections remained elevated in 2007 (10 eyes) and 2008 (14 eyes), including contact lens-related infections (3 in 2007 and 6 in 2008).
  
  
  CONCLUSIONS
  A definite increase in the number of fungal keratitis cases began in 2004 and continued through 2006 during the Fusarium outbreak associated with ReNu with MoistureLoc. Despite the decrease in contact lens-related Fusarium infections, the overall number of fungal keratitis cases remained high through 2008. Fungal keratitis was more often associated with contact lens use than with trauma in this time.
authors.affiliation: Cornea Service, Wills Eye Institute, Department of Ophthalmology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Elvin H
authors.initials: EH
authors.lastname: Yildiz
authors.forename: Yasmine F
authors.initials: YF
authors.lastname: Abdalla
authors.forename: Ahmed F
authors.initials: AF
authors.lastname: Elsahn
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Rapuano
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Hammersmith
authors.forename: Peter R
authors.initials: PR
authors.lastname: Laibson
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003261:Contact Lenses / Q000009:adverse effects / Q000382:microbiology; D003320:Corneal Ulcer / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D015143:Philadelphia / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult