Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression.
The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and prostaglandin F2α-induced luteal regression. In addition, further uses of these databases are discussed, as well as limitations of both array technology and the rhesus macaque genome array.
Bishop
C V
CV
Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA. bishop@ohsu.edu
Bogan
R L
RL
Hennebold
J D
JD
Stouffer
R L
RL
D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D003341:Luteolysis / Q000235:genetics / Q000378:metabolism*; D008251:Macaca / Q000235:genetics / Q000378:metabolism*; D008597:Menstrual Cycle / Q000235:genetics / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D011453:Prostaglandins / Q000494:pharmacology
D011453:Prostaglandins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone