Concomitant adenocarcinoma and colonic non-Hodgkin's lymphoma in a patient with ulcerative colitis: a case report and molecular analysis.
Ulcerative colitis (UC) complicated by colonic lymphoma is rare, although UC is often accompanied by adenocarcinoma of the colon. A concurrent existence of adenocarcinoma and lymphoma in a patient with UC is extremely rare, and has not yet been analyzed at the molecular level. We report a 64-year-old female patient with concomitant adenocarcinoma and diffuse large B-cell lymphoma (DLBCL) in the colon of UC. The genetic changes in these two neoplasms were analyzed. The colon adenocarcinomas had a mutation in MSH6 gene, DNA methylation in CDKN2A gene, and increased microsatellite instability (MSI), although these genetic changes were not recognized in either DLBCL or non-neoplastic UC mucosa. The DLBCL was diagnosed as primary colonic lymphoma, and confirmed Epstein-Barr virus (EBV) infection. The adenocarcinomas and the non-neoplastic UC mucosa were EBV-negative. Our case presented here clearly shows that the development of adenocarcinoma and lymphoma in the colon with UC was caused by individual mechanisms.
Nishigami
Takashi
T
Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Kataoka
Tatsuki R
TR
Torii
Ikuko
I
Sato
Ayuko
A
Tamura
Kazuo
K
Hirano
Hiroshi
H
Hida
Nobuyuki
N
Ikeuchi
Hiroki
H
Tsujimura
Tohru
T
D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics / Q000473:pathology*; D003110:Colonic Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins / Q000235:genetics*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D019942:Genes, p16; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000821:virology*; D053842:Microsatellite Instability; D008875:Middle Aged; D009154:Mutation; D011239:Prednisolone / Q000627:therapeutic use
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D011239:Prednisolone