title: Mode of onset of polymorphic ventricular tachycardia in acute myocardial infarction.
abstract: BACKGROUND
  Polymorphic ventricular tachycardia (PVT) can occur during acute myocardial infarction (MI). In the past, studies investigated the initiation pattern of ventricular tachycardias in different patient populations; however, the mode of onset of PVT in acute MI patients has not been investigated previously.
  
  
  OBJECTIVE
  To retrospectively investigate the electrophysiological features of PVT with different initiation patterns in acute MI patients to assess whether there is a relationship of the initiation patterns of PVT with clinical and electrophysiological characteristics.
  
  
  METHODS
  Sixty-two rhythm strips defined as PVT from 53 patients (mean [± SD] age 63±8 years) with acute ST elevation MI were analyzed. All patients were monitored while they were hospitalized in the coronary care unit, and the electrocardiogram strips were obtained from continuous monitoring. PVT was defined as sudden-onset tachycardia if it was not preceded by ventricular ectopic beats. PVT that was preceded by single or multiple ectopic beats was defined as nonsudden-onset tachycardia.
  
  
  RESULTS
  Nonsudden-onset episodes were more common than suddenonset episodes (40 episodes [64.5%] versus 22 episodes [35.5%]). In the nonsudden-onset group, 25 episodes (62.5%) were initiated after a single ectopic beat, while 15 episodes (37.5%) were initiated after multiple complexes. The mean (± SD) left ventricular ejection fraction of patients with nonsudden-onset PVT was decreased (53±6% versus 65±7%, P<0.01). Nonsudden-onset tachycardias had lower coupling intervals than suddenonset tachycardias. Similarly, the PVT cycle length was shorter in the presence of nonsudden-onset initiation. When nonsudden-onset PVT episodes were further subclassified based on the morphology of the first beat of tachycardia, 26 PVTs (65%) had a first beat of tachycardia similar to the subsequent PVT beats and 14 (35%) did not.
  
  
  CONCLUSIONS
  These results demonstrate that PVT is often preceded by ventricular ectopy in acute MI patients. Nonsudden-onset PVT is usually characterized by a lower coupling interval, shorter PVT cycle length and an associated lower ejection fraction.
authors.affiliation: Cardiology Department, Eskisehir Osmangazi University, Eskisehir, Turkey. bulent@gorenek.com
authors.forename: Bulent
authors.initials: B
authors.lastname: Gorenek
authors.forename: Osman
authors.initials: O
authors.lastname: Cengiz
authors.forename: Gulmira
authors.initials: G
authors.lastname: Kudaiberdieva
authors.forename: Ilker
authors.initials: I
authors.lastname: Durak
authors.forename: Volkan
authors.initials: V
authors.lastname: Dogan
authors.forename: Binnur
authors.initials: B
authors.lastname: Yasar
authors.forename: Alparslan
authors.initials: A
authors.lastname: Birdane
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Cavusoglu
authors.forename: Necmi
authors.initials: N
authors.lastname: Ata
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*