title: [Association between interferon regulatory factor 6 gene polymorphism and non-syndromic oral clefting].
abstract: OBJECTIVE
  To investigate the association between interferon regulatory factor 6 (IRF6) gene polymorphism and non-syndromic oral clefting (NSOC).
  
  
  METHODS
  Experimental group consisted of 186 Ningxia NSOC patients, their parents (183 fathers and 174 mothers), 172 core families (patient+parents), and control group consisted of 200 normal children. DNA was extracted and PCR-restriction fragment length polymorphism (PCR-RFLP) was used to identify the genotypes of the samples, case-control analyses and transmission-disequilibrium test (TDT) were carried out.
  
  
  RESULTS
  Compared with control group, there were significant differences in both rs642961's and rs4844880's AA genotype and A allele among NSOC patients (P < 0.05), but no difference in cleft palate (P = 0.15, P = 0.967, respectively). In TDT analysis, the A allele of rs642961 had a strong over-transmission in NSOC (P < 0.05), so did the rs4844880'A allele (P < 0.05), but neither of them had significant difference in cleft palate (P = 0.91, P = 0.95, respectively).
  
  
  CONCLUSIONS
  IRF6 gene polymorphism is associated with NSOC.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, College of Stomatology, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Hong-wang
authors.initials: HW
authors.lastname: Ren
authors.forename: Gui-zhi
authors.initials: GZ
authors.lastname: Zhao
authors.forename: Yong-qing
authors.initials: YQ
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Ma
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Yan-bo
authors.initials: YB
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Bing
authors.initials: B
authors.lastname: Shi
mesh_terms: D016022:Case-Control Studies; D002972:Cleft Palate / Q000235:genetics*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C109803:IRF6 protein, human; D050835:Interferon Regulatory Factors