title: APOE ε2 allele is associated with larger regional cortical thicknesses and volumes.
abstract: BACKGROUND
  The protective effect of the apolipoprotein E (APOE) ε2 allele against Alzheimer's disease (AD) is controversial.
  
  
  OBJECTIVE
  Our purpose was to clarify if the ε2 allele affects regional cortical thicknesses and volumes.
  
  
  METHODS
  Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls.
  
  
  RESULTS
  In the mild cognitive impairment group, the ε2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with ε3/ε3, and a larger cerebral gray matter and smaller lateral ventricles than the ε3/ε3 and ε4 carriers. In the AD group, the ε2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the ε3/ε3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than ε4 carriers. No APOE2 effect was found in the control group.
  
  
  CONCLUSIONS
  The APOE ε2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD.
authors.affiliation: Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Yawu
authors.initials: Y
authors.lastname: Liu
authors.forename: Teemu
authors.initials: T
authors.lastname: Paajanen
authors.forename: Eric
authors.initials: E
authors.lastname: Westman
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Andrew
authors.initials: A
authors.lastname: Simmons
authors.forename: Catherine
authors.initials: C
authors.lastname: Tunnard
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sobow
authors.forename: Petroula
authors.initials: P
authors.lastname: Proitsi
authors.forename: John
authors.initials: J
authors.lastname: Powell
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Sebastian
authors.initials: S
authors.lastname: Muehlboeck
authors.forename: Alan
authors.initials: A
authors.lastname: Evans
authors.forename: Christian
authors.initials: C
authors.lastname: Spenger
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology; D053329:Apolipoprotein E2 / Q000235:genetics*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000473:pathology; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests
chemical_list: D053329:Apolipoprotein E2