Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy.
It is becoming apparent that a number of pathogenic mechanisms contribute to diabetic neuropathy, so that therapeutic interventions that target one particular mechanism may have limited success. A recently published preclinical study has adopted an alternative approach by using a novel small molecule to induce heat-shock protein 70. This confers upon neurons, and perhaps other cells of the nervous system, the ability to better tolerate the diverse stresses associated with diabetes rather than intervening in their production.
Calcutt
Nigel A
NA
Department of Pathology, University of California-San Diego, La Jolla, CA 92093, U.S.A. ncalcutt@ucsd.edu
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D010147:Pain Measurement; D011984:Sensory Receptor Cells / Q000378:metabolism*
D018841:HSP90 Heat-Shock Proteins