title: Functionalizable collagen model peptides.
abstract: The functionalizability and conformational properties of azidoproline (Azp)-containing collagen model peptides (CMPs) were studied. The results show that (4R)Azp has a similar stabilizing effect on the collagen triple helix as (4R)hydroxyproline and that functionalized CMPs are readily accessible by "click" chemistry. The resulting triazole-functionalized CMPs form stable triple helices, demonstrating that sterically demanding moieties in three symmetry-related positions in all strands are tolerated. The straightforward synthesis and facile functionalizability of the Azp-containing CMPs are intriguing for the development of functional collagen-based materials.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
authors.forename: Roman S
authors.initials: RS
authors.lastname: Erdmann
authors.forename: Helma
authors.initials: H
authors.lastname: Wennemers
mesh_terms: D003094:Collagen / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*
chemical_list: D010455:Peptides; D003094:Collagen