title: Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consecutive patients.
abstract: OBJECTIVE
  To analyze the clinical manifestations and risk factors of complications in laparoscopic low anterior resection (LAR) for rectal cancer patients.
  
  
  METHODS
  A series of 132 consecutive patients who received laparoscopic LAR for rectal cancer in our center were included. The etiology, diagnosis, treatment and prevention of rectal cancer were studied among the patients with surgery-related complications using both univariate and multivariate regression analysis.
  
  
  RESULTS
  No conversion to open surgery was observed and 5 cases converted to hand-assisted laparoscopic operation. The overall morbidity rate was 20.5%. Complications occurred during the operation in 7 patients (5.3%), within 30 postoperative days in 24 patients (18.2%), and within 3 mo in 2 patients (1.5%). The most significant complications were anastomotic leakage (9.1%) and anastomotic hemorrhage (5.3%). Size and location of tumor, pathological staging and preoperative nutrition were significant factors associated with LAR complications, while gender, age and pathological type showed no relevance. Binary logistics regression showed that the size and location of tumor, and pathological staging were independent factors of laparoscopic LAR. All the complications were treated during their onset of clinical manifestations by interventional or conservative therapy.
  
  
  CONCLUSIONS
  Anastomotic leakage is a major complication in laparoscopic LAR. The complications may be associated with tumor size and site, and pathological stage. Interventional therapies are of value in the management of laparoscopic LAR complications.
authors.affiliation: Department of General Surgery, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Qian-Lin
authors.initials: QL
authors.lastname: Zhu
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Lu
authors.forename: Ming-Liang
authors.initials: ML
authors.lastname: Wang
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Hu
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Li
authors.forename: Zhi-Hai
authors.initials: ZH
authors.lastname: Mao
authors.forename: Min-Hua
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D057868:Anastomotic Leak; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D016896:Treatment Outcome