title: A new diimide derivative from the co-culture broth of two mangrove fungi (strain no. E33 and K38).
abstract: A new diimide derivative, named (-)-byssochlamic acid bisdiimide (1), was isolated from the mixed broth of two mangrove fungi (strain no. K38 and E33) from the South China sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) and semi-synthesis. Primary bioassays showed that 1 had weak cytotoxic activity against Hep-2 and HepG2 cells.
authors.affiliation: College of Science, Institute of Biomaterial, South China Agricultural University, Guangzhou, China.
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Li
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Ding
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Yong-Cheng
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D056945:Hep G2 Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D006575:Heterocyclic Compounds, 3-Ring; D007094:Imides; C552795:byssochlamic acid bisdiimide; C010875:byssochlamic acid