Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease.
The activity of the β-secretase involved in the cleavage of amyloid-β (Aβ) is increased in sporadic late-onset Alzheimer's disease (AD). Whether the corresponding γ-secretase activity is altered is still uncertain. We evaluated mRNA expression and protein levels of presenilin 1 (PS1) and γ-secretase activity in the frontal cortex of 32 cases with late-onset sporadic AD and those of 29 control subjects. We found a significant increase in PS1 mRNA, protein levels and γ-secretase activity in AD cases. These findings suggest that upregulation of PS1 leads to Aβ overproduction and accumulation in sporadic AD.
Borghi
Roberta
R
Department of Internal Medicine, University of Genova, Genova, Italy.
Piccini
Alessandra
A
Barini
Erica
E
Cirmena
Gabriella
G
Guglielmotto
Michela
M
Tamagno
Elena
E
Fornaro
Michele
M
Perry
George
G
Smith
Mark A
MA
Garuti
Anna
A
Tabaton
Massimo
M
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000096:biosynthesis; D001921:Brain / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D053764:Presenilin-1 / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D015854:Up-Regulation / Q000502:physiology*
D053764:Presenilin-1; D012333:RNA, Messenger; D053829:Amyloid Precursor Protein Secretases