title: Predonation quality of life and early postdonation safety of older living renal donors in China.
abstract: BACKGROUND
  Studies on the safety of older living renal donors are lacking in China.
  
  
  METHODS
  We observed 142 consecutive living renal donors before and early after (7 days) the operation. There were no prisoners used as donors or recipients. Subjects were divided into 2 groups: older than 50 years of age (n = 40) or younger age (n = 102). We compared differences in early safety between the 2 groups.
  
  
  RESULTS
  There were no significant differences in 8 aspects of the predonation quality of life using the SF-36 questionnaire, except for physical function (P < .001). Zero hour biopsies performed on 52 kidneys showed 15 to display abnormal renal tissues (28.85%), which was significantly greater among the older age group (P = .034). The perioperative indexes were similar between the 2 groups; however, the hospital stay was longer in the older group (P = .034). Compared with the younger group, the older group generally showed a lower creatinine clearance (CCr; P < .001), higher cystatin c (P = .006), and similar serum creatinine (Scr) preoperatively, conditions that persisted at 7 days postoperatively. Although the increased Scr and reduced CCr were present in all donors, the changes in Scr and CCr were similar between the 2 groups. Differences in urinary micro-albumin and proteinuria before and after operation were not significantly different for both groups.
  
  
  CONCLUSIONS
  Increased use of older living kidney donors in China may be a safe strategy to meet the demand for transplantation. However, long-term outcomes need further follow-up.
authors.affiliation: Organ Transplant Center, 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Qiu
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Fei
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Deng
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000419:Albuminuria / Q000453:epidemiology / Q000209:etiology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002681:China; D005190:Family; D006801:Humans; D019520:Living Donors / Q000523:psychology*; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods / Q000523:psychology*; D059035:Perioperative Period / Q000523:psychology; D011507:Proteinuria / Q000453:epidemiology / Q000209:etiology; D011788:Quality of Life; D012449:Safety