title: Gender differences in bone mineral density in obese children during pubertal development.
abstract: OBJECTIVE
  To investigate whether body mass index (BMI) and body composition can affect peak bone mass in a population of obese (OB) (BMI SDS>2.0) and normal weight (NORM) (BMI-SD score <2.0) pubertal subjects (Tanner stage T3 to T5).
  
  
  METHODS
  151 subjects (81 OB, age 14.5±2.4 yr) were analyzed using dual-X-ray absorbiometry technique to study Lumbar and whole body bone mineral density (BMD) (areal, normalized for height) and Z-score, lean mass (LM) and lean/fat ratio.
  
  
  RESULTS
  As a whole group, OB males did not show any significant difference in bone parameters vs NORM, while OB females showed higher bone density parameters (p<0.05). When grouped according to T, while OB males showed higher bone density at T3-4 stage (p<0.01), and lower at T5 (p<0.01) compared to NORM, OB females showed a tendency through increased BMD at T3-4 and T5 although statistically different only at T5. BMD was independently correlated to LM, lean/fat ratio, and testosterone in NORM males and, at lower level, in OB males, while to LM in NORM females and only to age in OB females.
  
  
  CONCLUSIONS
  Our data seem to confirm the possible negative influence of obesity on bone density in boys, a possible explanation could be an unfavorable body composition during sexual maturation that seems not to affect bone development in adolescents girls.
authors.affiliation: Cardiorespiratory and Sport Medicine Unit, Bambino Gesù Children's Hospital, IRCCS, P.za San Onofrio, 4, 00165 Rome, Italy. dfintini@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Fintini
authors.forename: C
authors.initials: C
authors.lastname: Brufani
authors.forename: A
authors.initials: A
authors.lastname: Grossi
authors.forename: G
authors.initials: G
authors.lastname: Ubertini
authors.forename: R
authors.initials: R
authors.lastname: Fiori
authors.forename: L
authors.initials: L
authors.lastname: Pecorelli
authors.forename: A
authors.initials: A
authors.lastname: Calzolari
authors.forename: M
authors.initials: M
authors.lastname: Cappa
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D001846:Bone Development / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity; D011627:Puberty / Q000502:physiology*; D012727:Sex Characteristics; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol