title: [Mechanisms of influenza virus replication].
abstract: The influenza A virus genome consists of eight, single-stranded, negative-sense RNA segments. Unlike most negative-sense RNA viruses, transcription and replication of the influenza A virus genome occurs in the nucleus of cells. Once synthesized, the genomic RNA is exported to the cytoplasm and then to the apical plasma membrane, where a complete set of the eight viral RNA segments is packaged into progeny virions. Here, we discuss the influenza A virion structure and its replication steps in host cells.
authors.affiliation: International Research Center for Infectious Diseases.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Noda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000821:virology; D003593:Cytoplasm / Q000821:virology; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D010949:Plasma / Q000821:virology; D012367:RNA, Viral; D014158:Transcription, Genetic; D014771:Virion / Q000737:chemistry / Q000235:genetics; D014779:Virus Replication
chemical_list: D012367:RNA, Viral