title: Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2.
abstract: We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Blvd, Tucson, AZ 85721, USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Porter
authors.forename: Mark R
authors.initials: MR
authors.lastname: Helmers
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Furman
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Joy
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
authors.forename: Indraneel
authors.initials: I
authors.lastname: Ghosh
mesh_terms: D006801:Humans; D008958:Models, Molecular; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000037:antagonists & inhibitors*; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2