title: [Effects of neurotrophin 3 on interdigestive migrating motor complex in rats with acute liver injury.].
abstract: OBJECTIVE
  To observe the effects of neurotrophin 3(NT-3)on interdigestive migrating motor complex (MMC) in rats with D-galactosamine induced acute liver injury.
  
  
  METHODS
  Twenty-four specific pathogen-free purebred rats were equally randomized into control and acute liver injury groups. The control group was injected with equal volume of normal saline via tail vein. Acute liver injury model of the rats was induced by D-galactosamine injection via the tail vein in the acute liver injury group. And the indexes of interdigestive MMC before and after NT-3 injection were recorded by a polygraph and analyzed in model group. The serum NT-3 concentration was assayed in the two groups.
  
  
  RESULTS
  There were no significant changes of gastrointestinal MMC cycle and jejunal phase I MMC after NT-3 injection. Compared with the acute liver injury rats before NT-3 injection , the antral phases I, III and IV MMC were significantly prolonged [(577.44 ± 248.60)s vs (343.58 ± 227.30) s, (80.94 ± 21.15) s vs (24.76 ± 7.41) s, (405.69 ± 131.34) s vs (191.67 ± 128.15) s, P < 0.05] and the phase II MMC was shortened [ (883.94 ± 488.50) s vs (1519.00 ± 831.14) s, P < 0.05] in the acute liver injury group. The duodenal phases I, III and IV MMC were significantly prolonged [ (557.63 ± 335.14) s vs (309.46 ± 220.22) s,(75.91 ± 15.75) s vs (31.15 ± 13.67) s, (423.38 ± 135.22) s vs (209.77 ± 123.83) s, P < 0.05] and MMC II phase was shortened [ (748.81 ± 579.69) s vs (1535.86 ± 930.50) s, P < 0.05] in the acute liver injury rats. In addition, the jejunal MMC III and MMC IV phase was significantly prolonged [ (86.58 ± 23.40) s vs (31.41 ± 16.09) s,(385.18 ± 110.02) s vs (220.59 ± 159.30) s, P < 0.05] and phase II MMC was shortened [ (876.89 ± 652.01) s vs (1870.89 ± 1010.35) s, P < 0.05 ] in the acute liver injury rats. The serum NT-3 level was significantly higher in model group than in control group.
  
  
  CONCLUSIONS
  NT-3 could enhance the gastrointestinal motility in acute liver injury rats.
authors.affiliation: Artificial Liver Treatment and Training Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. maybelake@126.com
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Wei-hong
authors.initials: WH
authors.lastname: Xu
authors.forename: Zhong-ping
authors.initials: ZP
authors.lastname: Duan
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Su-jun
authors.initials: SJ
authors.lastname: Zheng
authors.forename: Xu-hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Mei
authors.initials: M
authors.lastname: Ding
authors.forename: Zhi-wu
authors.initials: ZW
authors.lastname: Lv
mesh_terms: D000818:Animals; D004063:Digestion / Q000502:physiology; D005260:Female; D005688:Galactosamine; D005769:Gastrointestinal Motility / Q000502:physiology*; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000187:drug effects* / Q000502:physiology; D020933:Neurotrophin 3 / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020933:Neurotrophin 3; D005688:Galactosamine