title: The pattern recognition molecule deleted in malignant brain tumors 1 (DMBT1) and synthetic mimics inhibit liposomal nucleic acid delivery.
abstract: Liposomal nucleic acid delivery is a preferred option for therapeutic settings. The cellular pattern recognition molecule DMBT1, secreted at high levels in various diseases, and synthetic mimics efficiently inhibit liposomal nucleic acid delivery to human cells. These findings may have relevance for therapeutic nucleic acid delivery strategies.
authors.affiliation: Lundbeckfonden Center of Excellence NanoCAN, University of Southern Denmark, 5000 Odense C, Denmark.
authors.forename: Pernille Lund
authors.initials: PL
authors.lastname: Hansen
authors.forename: Stephanie
authors.initials: S
authors.lastname: Blaich
authors.forename: Caroline
authors.initials: C
authors.lastname: End
authors.forename: Steffen
authors.initials: S
authors.lastname: Schmidt
authors.forename: Jesper B
authors.initials: JB
authors.lastname: Moeller
authors.forename: Uffe
authors.initials: U
authors.lastname: Holmskov
authors.forename: Jan
authors.initials: J
authors.lastname: Mollenhauer
mesh_terms: D000818:Animals; D001665:Binding Sites; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002135:Calcium-Binding Proteins; D002460:Cell Line; D004268:DNA-Binding Proteins; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D009077:Mucins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D025521:Tumor Suppressor Proteins
chemical_list: D002135:Calcium-Binding Proteins; C108174:DMBT1 protein, human; D004268:DNA-Binding Proteins; C114202:Dmbt1 protein, mouse; D008081:Liposomes; D009077:Mucins; D009696:Nucleic Acids; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; D025521:Tumor Suppressor Proteins