title: [Clinical trial on standard treatment of acute organophosphorus poisoning].
abstract: OBJECTIVE
  To explore the norms of treatment of acute organophosphorus pesticide poisoning (AOPP), and observe the curative effect.
  
  
  METHODS
  On basis of the pre-research, the norms of treatment of AOPP were summarized, and a multi-center clinical trial was performed in 6 hospitals selected from high incidence of AOPP in Shandong Province.
  
  
  RESULTS
  422 patients of AOPP in 6 hospitals in observation period were treated and observed by the norms of treatment. Among them, the proportion of oral poisoning was 97.16%, middle and severe degree were 87.44%. Compared with themselves 2 years ago before standard treatment, the curative effect of the norms of treatment for AOPP was much better than before. The mortality rate of AOPP declined from 9.87% to 1.66% (Chi2 = 27.92, P < 0.01), that was much better than the average therapeutic effect level of all our province in the same period (the mortality rate: 8.92%) (Chi2 = 26.05, P < 0.01). The average amount of atropine [(37.54 +/- 17.76) mg], dropped greatly [(1280.70 +/- 69.22) mg] (U = 439.22, P < 0.01).The usage of atropine by continuous intravenous injection with venous pump was better than ordinary intravenous injection. The mean dosage of pralidoxime chloride increased twice than the previous (U = 19.48, P < 0.01). There was no drug poisoning.
  
  
  CONCLUSIONS
  The standard treatment of AOPP is urgently needed in our country, especially in rural area. By this trial, the satisfactory effect of the norms of treatment for AOPP summarized is observed and it reduces the fatality rate remarkably.
authors.affiliation: Shandong Academy of Labour Hygiene and Occupational Disease, Jinan 250002, China.
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Yan
authors.forename: Xiu-Ju
authors.initials: XJ
authors.lastname: Li
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Ning
authors.forename: Xue-Bin
authors.initials: XB
authors.lastname: Zhao
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Pan
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Yan
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Li
authors.forename: Xiu-Wei
authors.initials: XW
authors.lastname: Zhang
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D010575:Pesticides / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy*; D059039:Standard of Care / Q000592:standards*; D055815:Young Adult
chemical_list: D010575:Pesticides