title: Lactobacillus rhamnosus meningitis following recurrent episodes of bacteremia in a child undergoing allogeneic hematopoietic stem cell transplantation.
abstract: We report a case of meningitis due to Lactobacillus rhamnosus in a child undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia. Four episodes of bacteremia involving strains with pulsotypes identical to that of the cerebrospinal fluid isolate preceded meningitis. After several courses of clindamycin, no relapse occurred during the patient follow-up.
authors.affiliation: CHU Clermont-Ferrand, Laboratoire de Bactériologie Clinique, Clermont-Ferrand F-63003, France. frobin@chu-clermontferrand.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Robin
authors.forename: Catherine
authors.initials: C
authors.lastname: Paillard
authors.forename: Hélène
authors.initials: H
authors.lastname: Marchandin
authors.forename: François
authors.initials: F
authors.lastname: Demeocq
authors.forename: Richard
authors.initials: R
authors.lastname: Bonnet
authors.forename: Claire
authors.initials: C
authors.lastname: Hennequin
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000382:microbiology; D015373:Bacterial Typing Techniques; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D052201:Lacticaseibacillus rhamnosus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008969:Molecular Sequence Data; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012008:Recurrence; D017422:Sequence Analysis, DNA; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D002981:Clindamycin