title: Flavonoids of Enhydra fluctuans exhibit anticancer activity against Ehrlich's ascites carcinoma in mice.
abstract: Flavonoids obtained from Enhydra fluctuans (FEF) were screened for anticancer activity against Ehrlich's ascites carcinoma (EAC) bearing Swiss albino mice. The anticancer activity was assessed by measuring the tumor growth response, percentage increase of life span, hematological parameters, lipid peroxidation, and antioxidant enzyme activity, like GSH and CAT. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Treatment with FEF caused a significant decrease in the tumor cell volume and increase of life span. All the hematological parameters, malonaldehyde content and antioxidant enzyme activity were restored towards the normal level. FEF was found to be cytotoxic in the in-vitro model.
authors.affiliation: NSHM College of Pharmaceutical Technology, 124 B.L. Saha Road, Kolkata- 700053, West Bengal, India. santanuin@rediffmail.com
authors.forename: Santanu
authors.initials: S
authors.lastname: Sannigrahi
authors.forename: Upal Kanti
authors.initials: UK
authors.lastname: Mazumder
authors.forename: Arijit
authors.initials: A
authors.lastname: Mondal
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
authors.forename: Silpi Lipsa
authors.initials: SL
authors.lastname: Mishra
authors.forename: Souvik
authors.initials: S
authors.lastname: Roy
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D019659:Asteraceae / Q000737:chemistry*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids