The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics.
Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.
Liu
Jia
J
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Rd, P.O. box 100266, Gainesville, FL 32610, USA.
Wennier
Sonia
S
McFadden
Grant
G
D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism* / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods; D009233:Myxoma virus / Q000276:immunology*; D050504:Oncolytic Viruses / Q000276:immunology*; D011817:Rabbits; D014764:Viral Proteins / Q000378:metabolism* / Q000627:therapeutic use
D007155:Immunologic Factors; D014764:Viral Proteins