Metabolism and pharmacokinetics of contraceptive steroids in obese women: a review.
The effect of obesity on drug metabolism and pharmacokinetics is poorly understood, and this is particularly true in regard to contraceptive steroids. This article will review the known and theoretical physiologic and pharmacologic interactions between obesity and contraceptive steroids.
Edelman
Alison B
AB
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA. edelmana@ohsu.edu
Cherala
Ganesh
G
Stanczyk
Frank Z
FZ
D003278:Contraceptives, Oral, Hormonal / Q000378:metabolism* / Q000493:pharmacokinetics*; D004997:Ethinyl Estradiol / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D011372:Progestins / Q000378:metabolism / Q000493:pharmacokinetics; D012869:Skin Absorption; D013256:Steroids / Q000378:metabolism / Q000493:pharmacokinetics
D003278:Contraceptives, Oral, Hormonal; D011372:Progestins; D013256:Steroids; D004997:Ethinyl Estradiol