title: Exploring the binding site of C-terminal hsp90 inhibitors.
abstract: The 90 kDa heat shock protein (Hsp90) is a prominent target for anticancer drug discovery. While its N-terminal domain has been widely exploited, several lines of evidence are emerging in favor of targeting its C-terminal domain to conceive innovative drugs based on perturbation of the dimer interface. Here, we describe the application of several computational approaches useful to predict the location of the C-terminal binding site.
authors.forename: Miriam
authors.initials: M
authors.lastname: Sgobba
authors.forename: Rosetta
authors.initials: R
authors.lastname: Forestiero
authors.forename: Gianluca
authors.initials: G
authors.lastname: Degliesposti
authors.forename: Giulio
authors.initials: G
authors.lastname: Rastelli
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D018841:HSP90 Heat-Shock Proteins