title: Clinical analysis of living related renal transplantation with donors older than 50 years in China.
abstract: OBJECTIVE
  The objective of this study was to investigate whether kidney grafts from living related donors older than 50 years were safe for the donors and recipients in the long term.
  
  
  METHODS
  One hundred seven living related donor kidney transplantations were performed in our center from April 1994 to December 2007. No prisoners or organs from prisoners were used in the collection of these data. Donors were divided into 2 groups: >50 years of age (range, 51-78 years), designated as the study group, and ≤50 years of age (range, 21-50 years), designated as the control groups. The mean time of follow-up was 49 months (range, 12-180 months). Clinical data were compared, including donor serum creatinine (Scr) levels, glomerular filtration rates (GFR) before and after the procedures operative complications, and postoperative short-term and long-term recovery of renal function in recipients as well as their complications and recipient and kidney survivals.
  
  
  RESULTS
  All operations were successfully performed. Before the operation, the mean Scr and GFR were 82.16 ± 10.86 umol/L and 85.82 ± 6.26 mL/min, respectively, in the study group versus 78.66 ± 10.41 umol/L and 88.74 ± 9.44 mL/min, respectively, in the control group. There were no significant differences in mean Scr or GFR values between the groups at various preoperative or postoperative times (P > .05). No severe perioperative complications occurred, and no subsequent renal function failure was observed upon long-term follow-up of donors in the 2 groups. Comparisons of recipient age, gender ratio, duration on dialysis, HLA matches, cold/warm ischemia times, and immunosuppression therapy showed a correlations between the 2 groups. Mean Scr levels of recipients, which were compared from 1 week to 3 years following surgery, were slightly higher among the control than the study group, but the difference was not significant (P > .05). There were no significant differences between the study and control groups in 1-,3-,5-, and 8-year recipient/graft survival rates (P > .05).
  
  
  CONCLUSIONS
  Long-term follow-up showed that transplantations using grafts from donors older than 50 years of age yielded similar results to those with younger donors.
authors.affiliation: Center of Kidney Transplantation, Linyi People’s Hospital, Shandong, China.
authors.forename: F F
authors.initials: FF
authors.lastname: Guo
authors.forename: Z-Q
authors.initials: ZQ
authors.lastname: Shao
authors.forename: W-Y
authors.initials: WY
authors.lastname: Yang
authors.forename: G-J
authors.initials: GJ
authors.lastname: Wang
authors.forename: S-F
authors.initials: SF
authors.lastname: Tan
authors.forename: X-F
authors.initials: XF
authors.lastname: He
authors.forename: J-M
authors.initials: JM
authors.lastname: Wang
authors.forename: H J
authors.initials: HJ
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: F G
authors.initials: FG
authors.lastname: Sun
authors.forename: W-B
authors.initials: WB
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D003404:Creatinine / Q000097:blood; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D003404:Creatinine