Old yeast can't handle the noise.
In this issue of Molecular Cell, Feser et al. (2010) show that aging yeast lose chromatin-associated histones and, furthermore, that correcting this deficiency robustly enhances replicative life span, indicating that loss of normal chromatin packing contributes to the aging process.
McCormick
Mark A
MA
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Kennedy
Brian K
BK