The myelin brake: when enough is enough.
Myelination by Schwann cells in the peripheral nervous system and by oligodendrocytes in the central nervous system is tightly regulated by interactions with axons. Various investigations have shed light on the signaling pathways that mediate the production of myelin, but an important question remains; that is, which signals determine when the cell stops myelinating. New studies demonstrate that in Schwann cells, this is controlled by the abundance of Dlg1, which acts to stop active myelination.
Macklin
Wendy B
WB
Department of Cell and Developmental Biology, University of Colorado Denver Health Science Center, Aurora, CO 80045, USA. wendy.macklin@ucdenver.edu
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D001369:Axons / Q000502:physiology*; D000074288:Discs Large Homolog 1 Protein; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D009186:Myelin Sheath / Q000378:metabolism / Q000502:physiology*; D020890:Neuregulin-1 / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; C513314:DLG1 protein, human; D000074288:Discs Large Homolog 1 Protein; D008565:Membrane Proteins; D020890:Neuregulin-1; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human