title: [Correlation of ornidazole concentration in saliva and serum of healthy volunteers].
abstract: OBJECTIVE
  To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.
  
  
  METHODS
  Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.
  
  
  RESULTS
  The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.
  
  
  CONCLUSIONS
  Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.
authors.affiliation: Department of Stomatology, General Hospital of PLA, Beijing 100853, China. qtww791001@sohu.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Hong-chen
authors.initials: HC
authors.lastname: Liu
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.forename: Chun-zhen
authors.initials: CZ
authors.lastname: Feng
authors.forename: Ping
authors.initials: P
authors.lastname: Chang
authors.forename: Xian-hua
authors.initials: XH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009950:Ornidazole / Q000032:analysis / Q000097:blood* / Q000493:pharmacokinetics*; D012463:Saliva / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D009950:Ornidazole