Visual compatibility of oritavancin diphosphate with selected coadministered drugs during simulated Y-site administration.
OBJECTIVE
The visual compatibility of the new intravenous antibiotic oritavancin diphosphate with various drugs commonly administered to patients in acute care settings was studied.


METHODS
Clinically used concentrations of 37 drugs, including antibiotics, sedatives, analgesics, and cardiovascular agents, were evaluated in 1:1 mixtures with oritavancin concentrations of 0.8, 1.2, and 2 mg/mL. Oritavancin solutions were prepared in 5% dextrose injection and mixed with each test drug solution. The mixtures were then visually observed over a period of four hours at room temperature. The pH of the mixtures was also determined immediately and four hours after mixing. Compatibility was defined as the absence of any color change, haze, fibers, particles, and precipitate.


RESULTS
Of the 37 tested drugs, 23 were visually compatible with all three concentrations of oritavancin over the four-hour study period. Drugs formulated at a basic or neutral pH were more likely to be incompatible with oritavancin.


CONCLUSIONS
Oritavancin diphosphate was visually incompatible with many intravenous drugs that are likely to be coadministered in acute care settings.
Kumar
Atul
A
College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. kuma0070@umn.edu
Mann
Henry J
HJ
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D011232:Chemical Precipitation; D003116:Color; D004344:Drug Incompatibility; D004355:Drug Stability; D004356:Drug Storage; D005947:Glucose / Q000737:chemistry*; D006020:Glycopeptides / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D000077427:Lipoglycopeptides; D019999:Pharmaceutical Solutions; D013997:Time Factors; D014640:Vancomycin / Q000031:analogs & derivatives
D000900:Anti-Bacterial Agents; D005947:Glucose; D006020:Glycopeptides; D000077427:Lipoglycopeptides; D019999:Pharmaceutical Solutions; C100708:oritavancin; D014640:Vancomycin