title: Stroke unit care in clinical practice: an observational study in the Florence center of the European Registers of Stroke (EROS) Project.
abstract: BACKGROUND
  Randomized trials and meta-analyses indicate positive effects of stroke unit (SU) care on survival and dependency of patients with stroke. However, data on the advantages of SU in 'real-world' settings are limited. We prospectively assessed, in a large University Hospital, the effect of SU versus other conventional wards (OCW) care on all-cause mortality, death or dependency, death or institutionalization.
  
  
  METHODS
  In a prospective observational study in the European Registers of Stroke Project, patients hospitalized for first-in-a-lifetime stroke were evaluated for demographics, risk factors, clinical presentation, resource use, 3-month and 1-year survival, and functional outcome.
  
  
  RESULTS
  Overall, 355 patients (54.1% men, mean age 73.4 ± 14.5 years) were registered, 140 (39.4%) admitted to the SU, and 215 (60.6%) to OCW. OCW patients were older, whilst SU patients had more severe strokes according to NIHSS (P for trend = 0.025). SU patients were significantly more often treated by specialists in stroke medicine, stroke nurses, physiotherapists and speech therapists (all P < 0.001), psychologists (P = 0.025), dietitians (P < 0.001), and social workers (P = 0.003). MRI, carotid, and transcranial Doppler were significantly more often performed in SU patients (all P < 0.001). Intravenous fluids (P = 0.003) and intravenous anticoagulation (P < 0.001) were more often prescribed in SU. Controlling for case-mix, SU significantly reduced 1-year mortality (P = 0.020), death or dependency at 3 months (P = 0.006) and 1 year (P = 0.043), and death or institutionalization at 3 months (P = 0.001) and 1 year (P = 0.009).
  
  
  CONCLUSIONS
  We confirmed the benefits of SU care in a clinical setting. Further analyses should define the contribution of individual components of care to stroke outcome.
authors.affiliation: Institute of Neurosciences, Italian National Research Council Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy. dicarlo@in.cnr.it
authors.forename: A
authors.initials: A
authors.lastname: Di Carlo
authors.forename: M
authors.initials: M
authors.lastname: Lamassa
authors.forename: I
authors.initials: I
authors.lastname: Wellwood
authors.forename: F
authors.initials: F
authors.lastname: Bovis
authors.forename: M
authors.initials: M
authors.lastname: Baldereschi
authors.forename: P
authors.initials: P
authors.lastname: Nencini
authors.forename: A
authors.initials: A
authors.lastname: Poggesi
authors.forename: A
authors.initials: A
authors.lastname: Cramaro
authors.forename: F
authors.initials: F
authors.lastname: Pescini
authors.forename: G
authors.initials: G
authors.lastname: Lucente
authors.forename: C D A
authors.initials: CD
authors.lastname: Wolfe
authors.forename: D
authors.initials: D
authors.lastname: Inzitari
mesh_terms: D000046:Academic Medical Centers / Q000379:methods*; D000368:Aged; D000369:Aged, 80 and over; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000401:mortality* / Q000628:therapy*