title: Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.
abstract: Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.
authors.affiliation: Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg-CNRS (UMR 7006), 8 allee Gaspard Monge, 67000 Strasbourg, France.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gorska
authors.forename: Julien
authors.initials: J
authors.lastname: Beyrath
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fournel
authors.forename: Gilles
authors.initials: G
authors.lastname: Guichard
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D000595:Amino Acid Sequence; D019281:Dimerization; D008024:Ligands; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000737:chemistry* / Q000378:metabolism*; D020349:Surface Plasmon Resonance
chemical_list: D008024:Ligands; D020135:Peptide Nucleic Acids; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand