PAPP-A: a new anti-aging target?
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
Conover
Cheryl A
CA
Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. Conover.Cheryl@Mayo.edu
D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D011266:Pregnancy-Associated Plasma Protein-A / Q000235:genetics / Q000378:metabolism*
D007334:Insulin-Like Growth Factor I; D011266:Pregnancy-Associated Plasma Protein-A