Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.
Through bioassay-guided fractionation and chromatography technique, eight indole alkaloids were furnished from the stems of Ervatamia hainanensis. All isolates were evaluated for acetylcholinesterase (AChE) inhibition activities, in which compounds 1 and 3 exhibited the same level of activities as galantamine, a marketed cholinesterase inhibitor for the treatment of Alzheimer's disease. Discussion about the relationships between structure and activity of these alkaloids was also presented.
Zhan
Zha-Jun
ZJ
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
Yu
Qi
Q
Wang
Zhan-Li
ZL
Shan
Wei-Guang
WG
D000110:Acetylcholinesterase / Q000378:metabolism; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005702:Galantamine / Q000494:pharmacology; D006860:Hydrogen Bonding; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology*; D008958:Models, Molecular; D008968:Molecular Conformation; D014101:Torpedo; D014961:X-Ray Diffraction
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D007211:Indoles; D005702:Galantamine; D000110:Acetylcholinesterase