Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor beta1 deficiency.
Patients with interleukin 12 (IL-12)p40 or IL-12 receptor β1 (IL12Rβ1) deficiencies are prone to develop infections caused by mycobacteria and salmonella; other infections have only been rarely observed. In this report we describe 2 unrelated patients with complete autosomal recessive IL12Rβ1 deficiency who suffered from sepsis attributable to Klebsiella pneumoniae. A Mexican boy suffered from disseminated bacille Calmette-Guérin disease and infections caused by K pneumoniae and Candida albicans and had a fatal outcome. A Turkish girl living in France suffered from disseminated Nocardia nova infection and K pneumoniae sepsis. Therefore, Klebsiella infections should be considered in patients with IL12Rβ1 deficiency. Conversely, IL12Rβ1 deficiency should be considered in patients with unexplained klebsiellosis.
Pedraza
Sigifredo
S
Unit of Biochemistry, National Institute for Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. spedraza@rocketmail.com
Lezana
Jose Luis
JL
Samarina
Arina
A
Aldana
Ruth
R
Herrera
Maria Teresa
MT
Boisson-Dupuis
Stéphanie
S
Bustamante
Jacinta
J
Pages
Perle
P
Casanova
Jean-Laurent
JL
Picard
Capucine
C
D001500:BCG Vaccine / Q000009:adverse effects; D002177:Candidiasis / Q000150:complications; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D053711:Interleukin-12 Receptor beta 1 Subunit / Q000235:genetics*; D007710:Klebsiella Infections / Q000150:complications / Q000235:genetics*; D007711:Klebsiella pneumoniae; D008297:Male; D009154:Mutation; D009163:Mycobacterium bovis; D009617:Nocardia Infections / Q000150:complications; D018805:Sepsis / Q000235:genetics*; D014388:Tuberculosis, Lymph Node / Q000150:complications
D001500:BCG Vaccine; D053711:Interleukin-12 Receptor beta 1 Subunit