title: T3 regulates E-cadherin, and β- and α-catenin expression in the stomach during the metamorphosis of the toad Rhinella arenarum.
abstract: The metamorphosis of Rhinella arenarum was induced precociously for 5 days, then blocked for 3 months to evaluate the role of thyroid hormones as modulators of morphoregulatory molecules such as E-cadherin, and β- and α-catenin during epithelium remodeling. We then performed an immunohistochemical and morphometric study of these molecules in the larval stomach. We show that 3,5,3'-triiodothyronine exerts a positive regulatory effect on E-cadherin and β- and α-catenin expression in stomach epithelium. This suggests continuous synthesis of E-cadherin, and β- and α-catenin; synthesis essentially is thyroid hormone-independent during premetamorphosis and early prometamorphosis, but it becomes thyroid hormone-dependent during metamorphic climax.
authors.affiliation: Microscopy Laboratory Applied to Cellular and Molecular Studies, Bioengineering and Bioinformatic School, National University of Entre Ríos, Ruta 11, Km 10, Oro Verde, Entre Ríos, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Izaguirre
authors.forename: V H
authors.initials: VH
authors.lastname: Casco
mesh_terms: D000818:Animals; D002025:Bufonidae / Q000254:growth & development* / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D008675:Metamorphosis, Biological; D013270:Stomach / Q000254:growth & development*; D014284:Triiodothyronine / Q000378:metabolism*; D051178:alpha Catenin / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D015820:Cadherins; D051178:alpha Catenin; D051176:beta Catenin; D014284:Triiodothyronine