title: Protease sensing with nanoparticle based platforms.
abstract: Nanoparticulate systems in various unique configurations are highly effective at detecting protease activity both in vivo and in vitro. In this article, we have summarised the conventional modern methods for monitoring protease activity, and critically appraised recent advances in protease-responsive nanosensors.
authors.affiliation: School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK NG7 2RD.
authors.forename: Katharina
authors.initials: K
authors.lastname: Welser
authors.forename: Rosemary
authors.initials: R
authors.lastname: Adsley
authors.forename: Bernadette M
authors.initials: BM
authors.lastname: Moore
authors.forename: Weng C
authors.initials: WC
authors.lastname: Chan
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Aylott
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D010450:Endopeptidases / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D049452:Green Fluorescent Proteins / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D045663:Quantum Dots; D013059:Spectrum Analysis, Raman
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers; D049452:Green Fluorescent Proteins; D010450:Endopeptidases