Alzheimer disease prevention: focus on cardiovascular risk, not amyloid?
Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.
Geldmacher
David S
DS
Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA. Dsg8n@virginia.edu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control*; D000682:Amyloid / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D004967:Estrogens / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D008928:Mitochondria; D008962:Models, Theoretical; D018384:Oxidative Stress; D047495:PPAR gamma / Q000819:agonists; D058225:Plaque, Amyloid; D012306:Risk; D045162:Thiazolidinediones / Q000494:pharmacology
D000682:Amyloid; D004967:Estrogens; D047495:PPAR gamma; D045162:Thiazolidinediones