title: Osteoinduction of porous titanium: a comparative study between acid-alkali and chemical-thermal treatments.
abstract: In this study, a slurry foaming method was developed to fabricate porous titanium, and two different surface treatments were applied to investigate their effects on the osteoinduction of the implants. Three types of implants, that was porous titanium with no treatment, with chemical-thermal treatment (CTPT), and with acid-alkali treatment (AAPT), were implanted in the dorsal muscles of adult dogs for 3 and 5 months. After implantation for 3 months, new bone was only found in the inner pores of AAPT by histological analysis and field emission scanning electron microscopy observation. After implantation for 5 months, new bone was also found in CTPT, but it was absent in AAPT. This study not only confirmed that porous titanium with appropriate surface treatments could possess osteoinduction but also showed that its osteoinductive potential was tightly related to the surface treatment. As a simpler method, acid-alkali treatment could endow porous titanium with faster osteoinduction, and AAPT might have potential in clinical application.
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China.
authors.forename: Chaoyong
authors.initials: C
authors.lastname: Zhao
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhu
authors.forename: Kailu
authors.initials: K
authors.lastname: Liang
authors.forename: Jietao
authors.initials: J
authors.lastname: Ding
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xiang
authors.forename: Hongsong
authors.initials: H
authors.lastname: Fan
authors.forename: Xingdong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000143:Acids; D000468:Alkalies; D000818:Animals; D001031:Apatites; D004285:Dogs; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis; D014025:Titanium
chemical_list: D000143:Acids; D000468:Alkalies; D001031:Apatites; D014025:Titanium