title: Chiral phosphaalkene-oxazoline ligands for the palladium-catalyzed asymmetric allylic alkylation.
abstract: Enantioselective catalysis in moderate to excellent yields and ee's has been accomplished using a phosphaalkene-based ligand system. Specifically, the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate using a chiral P(sp(2)),N(sp(2)) ligand proceeds with a variety of malonate nucleophiles in 73-95% yield (79-92% ee).
authors.affiliation: Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
authors.forename: Julien
authors.initials: J
authors.lastname: Dugal-Tessier
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Dake
authors.forename: Derek P
authors.initials: DP
authors.lastname: Gates
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000498:Allyl Compounds; D008024:Ligands; D010080:Oxazoles; D010710:Phosphates; D010165:Palladium