title: The relationship between migraine and right-to-left shunt in children.
abstract: Migraine is the most common headache in childhood, and there are some reports that suggest the relationship between migraine and right-to-left shunt. The aim of this study was to evaluate the frequency of right-to-left shunt in children with migraine with aura and compare it with children with migraine without aura, and in healthy children. In a cross-sectional case-control study, we assessed 20 children with migraine with aura, 20 migraine without aura and 20 healthy age, and gender-matched control group. We determined the frequency of right-to-left shunt by transcranial doppler with contrast and transthoracic echocardiography without contrast. The dopplers and echocardiograms were performed blindly by the same examiners during headache-free periods. The presence of right-to-left shunt was found in 13/20 patients with migraine with aura compared with five of 20 migraine without aura and four of 20 control subjects. The frequency of right-to-left shunt in migraine with aura was statistically different from the other two groups (P < 0.005). There was no association between right-to-left shunt and frequency of attacks, duration and intensity of attacks, uni/bilateral occurence, familial occurrence, gender and age of patients.
  
  
  CONCLUSIONS
  our findings suggest possible association of migraine with aura and right-to-left shunt. It seems that right-to-left shunt does not influence the clinical features of migraine.
authors.affiliation: Department of Pediatric Neurology, Faculty of Medicine, Ondokuz Mayis University, Kurupelit Kampusu 55139 Samsun, Turkey.
authors.forename: Sevcan
authors.initials: S
authors.lastname: Sarısoy
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Aydın
authors.forename: Metin
authors.initials: M
authors.lastname: Sungur
authors.forename: Ilkay Koray
authors.initials: IK
authors.lastname: Bayrak
authors.forename: Servet
authors.initials: S
authors.lastname: Aker
authors.forename: Hamit
authors.initials: H
authors.lastname: Özyürek
authors.forename: Haydar Ali
authors.initials: HA
authors.lastname: Taşdemir
authors.forename: Kemal
authors.initials: K
authors.lastname: Baysal
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006343:Heart Septal Defects / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000150:complications*; D020326:Migraine without Aura / Q000150:complications*; D014463:Ultrasonography