title: Bone regeneration by octacalcium phosphate collagen composites in a dog alveolar cleft model.
abstract: Octacalcium phosphate (OCP) and porcine atelocollagen sponge composites (OCP/Col) markedly enhanced bone regeneration in a rat cranial defect model. To assess clinical application, the authors examined whether OCP/Col would enhance bone regeneration in an alveolar cleft model in an adult dog, which was assumed to reflect patients with alveolar cleft. Disks of OCP/Col or collagen were implanted into the defect and bone regeneration by OCP/Col or collagen was investigated 4 months after implantation. Macroscopically, the OCP/Col-treated alveolus was obviously augmented and occupied by radio-opacity, and the border between the original bone and the defect was indistinguishable. Histological analysis revealed it was filled and bridged with newly formed bone; a small quantity of the remaining implanted OCP was observed. X-ray diffraction patterns of the area of implanted OCP/Col indicated no difference from those of dog bone. In the collagen-treated alveolus, the hollowed alveolus was mainly filled with fibrous connective tissue, and a small amount of new bone was observed at the defect margin. These results suggest that bone was obviously repaired when OCP/Col was implanted into the alveolar cleft model in a dog, and OCP/Col would be a significant bone regenerative material to substitute for autogeneous bone.
authors.affiliation: Division of Oral Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsui
authors.forename: A
authors.initials: A
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Handa
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: O
authors.initials: O
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Kamakura
authors.forename: S
authors.initials: S
authors.lastname: Echigo
mesh_terms: D000539:Alveolar Process / Q000002:abnormalities* / Q000601:surgery; D000543:Alveoloplasty / Q000379:methods*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations; D008297:Male
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D004338:Drug Combinations; C022045:octacalcium phosphate; D003094:Collagen