title: Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation.
abstract: The immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.
authors.affiliation: Sébastien Lacroix-Desmazes, INSERM UMR 872 Equipe 16, Centre de Recherche des Cordeliers, Paris, F-75006 France.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Navarrete
authors.forename: Suryasarathi
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Maud
authors.initials: M
authors.lastname: Teyssandier
authors.forename: Yohann
authors.initials: Y
authors.lastname: Repesse
authors.forename: Sandrine
authors.initials: S
authors.lastname: Delignat
authors.forename: Sébastien
authors.initials: S
authors.lastname: André
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
authors.forename: Srinivas V
authors.initials: SV
authors.lastname: Kaveri
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
mesh_terms: D000906:Antibodies / Q000097:blood*; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D001777:Blood Coagulation; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003029:Coagulants / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D004705:Endocytosis; D005169:Factor VIII / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D000906:Antibodies; D003029:Coagulants; D011956:Receptors, Cell Surface; D005169:Factor VIII