Effect of dietary conjugated linoleic acid supplementation on early inflammatory responses during cutaneous wound healing.
Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.
Park
Na-Young
NY
Department of Food and Nutrition, Research Institute of Science for Human Life, Kyung Hee University, Dongdaemun-gu, Seoul 130-761, Republic of Korea.
Valacchi
Giuseppe
G
Lim
Yunsook
Y
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000378:metabolism; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D005260:Female; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
D044243:Linoleic Acids, Conjugated; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D051547:Heme Oxygenase-1; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D013482:Superoxide Dismutase