Hepcidin and disorders of iron metabolism.
The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.
Ganz
Tomas
T
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. TGanz@mednet.ucla.edu
Nemeth
Elizabeta
E
D000375:Aging / Q000378:metabolism; D000740:Anemia / Q000378:metabolism; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism; D005260:Female; D022781:Hepatocytes / Q000378:metabolism; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000188:drug therapy / Q000378:metabolism*; D019266:Iron, Dietary / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D000098742:Ferroportin
D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; C578702:HAMP protein, human; C579599:Hamp protein, mouse; D064451:Hepcidins; D015850:Interleukin-6; D019266:Iron, Dietary; D014168:Transferrin; D000098742:Ferroportin; D007501:Iron