Random-walk mechanism in the genetic recombination.
We have explained some experimental data of the homologous recombination and the genetic interference in terms of one-dimensional random walk over discrete sites. We first review our previous results. Next, we modify our random-walk model for the homologous recombination into a continuous-site model, and discuss a possible explanation for the previous experimental data obtained by means of the plasmid having one-side homology. Finally, we show that a reaction between an intermediate and a product is indispensable in explaining the genetic interference in terms of our reaction-diffusion model.
Fujitani
Youhei
Y
Keio University, 223-8522 Yokohama, Japan. youhei@appi.keio.ac.jp
Kawai
Junji
J
Kobayashi
Ichizo
I
D000818:Animals; D019295:Computational Biology; D004926:Escherichia coli / Q000235:genetics; D018390:Gene Targeting; D005822:Genetic Vectors; D051379:Mice; D008957:Models, Genetic; D010957:Plasmids / Q000235:genetics; D011995:Recombination, Genetic