Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents.
An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation-asymmetric reduction sequence.
Mutti
Francesco G
FG
Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
Orthaber
Andreas
A
Schrittwieser
Joerg H
JH
de Vries
Johannes G
JG
Pietschnig
Rudolf
R
Kroutil
Wolfgang
W
D002384:Catalysis; D004798:Enzymes / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D010084:Oxidation-Reduction
D004798:Enzymes; D007202:Indicators and Reagents; D007495:Iridium