Highly organocatalytic asymmetric Michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles.
An efficient Michael-ketone aldol-dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).
Wang
Liang-Liang
LL
Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
Peng
Lin
L
Bai
Jian-Fei
JF
Huang
Qing-Chun
QC
Xu
Xiao-Ying
XY
Wang
Li-Xin
LX
D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D007211:Indoles; D007659:Ketones; D014867:Water