Fitness effects of replichore imbalance in Salmonella enterica.
A fitness cost due to imbalanced replichores has been proposed to provoke chromosome rearrangements in Salmonella enterica serovars. To determine the impact of replichore imbalance on fitness, the relative fitness of isogenic Salmonella strains containing transposon-held duplications of various sizes and at various chromosomal locations was determined. Although duplication of certain genes influenced fitness, a replichore imbalance of up to 16° did not affect fitness.
Matthews
T David
TD
Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, CA 92182-1010, USA.
Maloy
Stanley
S
D002876:Chromosomes, Bacterial; D004261:DNA Replication; D004251:DNA Transposable Elements; D020440:Gene Duplication; D015321:Gene Rearrangement; D016254:Mutagenesis, Insertional; D019779:Salmonella enterica / Q000235:genetics* / Q000254:growth & development*
D004251:DNA Transposable Elements