InCl3-catalyzed allylic Friedel-Crafts reactions toward the stereocontrolled synthesis of 1,2,3,4-tetrahydroquinolines.
Allyl chlorides tethered to an N-aryl moiety readily undergo InCl(3)-catalyzed Friedel-Crafts reactions to furnish highly enantiomerically enriched 1,2,3,4-tetrahydroquinolines with good yields and excellent diastereoselectivity.
Giera
David S
DS
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
Schneider
Christoph
C
D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000498:Allyl Compounds; D011804:Quinolines; D007204:Indium; C020758:indium trichloride; C542964:1,2,3,4-tetrahydroquinoline