Pumilio turns on microRNA function.
Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.
Triboulet
Robinson
R
Gregory
Richard I
RI
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D016601:RNA-Binding Proteins / Q000378:metabolism*
D020413:3' Untranslated Regions; D035683:MicroRNAs; D016601:RNA-Binding Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27