title: Effect of improving spatial or temporal resolution on image quality and quantitative perfusion assessment with k-t SENSE acceleration in first-pass CMR myocardial perfusion imaging.
abstract: k-t Sensitivity-encoded (k-t SENSE) acceleration has been used to improve spatial resolution, temporal resolution, and slice coverage in first-pass cardiac magnetic resonance myocardial perfusion imaging. This study compares the effect of investing the speed-up afforded by k-t SENSE acceleration in spatial or temporal resolution. Ten healthy volunteers underwent adenosine stress myocardial perfusion imaging using four saturation-recovery gradient echo perfusion sequences: a reference sequence accelerated by sensitivity encoding (SENSE), and three k-t SENSE-accelerated sequences with higher spatial resolution ("k-t High"), shorter acquisition window ("k-t Fast"), or a shared increase in both parameters ("k-t Hybrid") relative to the reference. Dark-rim artifacts and image quality were analyzed. Semiquantitative myocardial perfusion reserve index (MPRI) and Fermi-derived quantitative MPR were also calculated. The k-t Hybrid sequence produced highest image quality scores at rest (P = 0.015). Rim artifact thickness and extent were lowest using k-t High and k-t Hybrid sequences (P < 0.001). There were no significant differences in MPRI and MPR values derived by each sequence. Maximizing spatial resolution by k-t SENSE acceleration produces the greatest reduction in dark rim artifact. There is good agreement between k-t SENSE and standard acquisition methods for semiquantitative and fully quantitative myocardial perfusion analysis.
authors.affiliation: Division of Cardiovascular and Neuronal Remodelling, University of Leeds, Leeds, United Kingdom.
authors.forename: Neil
authors.initials: N
authors.lastname: Maredia
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Radjenovic
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.forename: Abdulghani
authors.initials: A
authors.lastname: Larghat
authors.forename: John P
authors.initials: JP
authors.lastname: Greenwood
authors.forename: Sven
authors.initials: S
authors.lastname: Plein
mesh_terms: D000328:Adult; D016477:Artifacts; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D016277:Ventricular Function, Left / Q000502:physiology*