title: Residual cervical lymphadenopathy after definitive treatment of nasopharyngeal carcinoma: fine needle aspiration cytology, computed tomography and histopathological findings.
abstract: BACKGROUND
  Patients with nasopharyngeal carcinoma may have residual cervical lymphadenopathy after definitive treatment of the primary tumour and regional cervical nodal disease. Whether such lymphadenopathy truly represents persistent disease is unclear. There are few published studies addressing this clinical problem.
  
  
  METHODS
  We retrospectively and systematically reviewed the clinical records of 12 patients with nasopharyngeal carcinoma who had presented to a tertiary academic hospital, over an 11-year period, with suspected persistent cervical nodal disease after definitive radiotherapy or concurrent chemoradiotherapy. Findings on fine needle aspiration cytology and computed tomography scanning were correlated with final histopathological results.
  
  
  RESULTS
  The incidence of negative neck dissection was 41.7 per cent. The positive and negative predictive values of fine needle aspiration cytology in identifying disease were 100 and 42.9 per cent, respectively. Computed tomography scanning had a positive predictive value of 58.3 per cent in identifying disease.
  
  
  CONCLUSIONS
  In patients treated definitively for nasopharyngeal carcinoma, residual cervical lymphadenopathy may not represent persistent disease. Head and neck surgeons involved in the management of these patients should bear in mind the current limitations of fine needle aspiration cytology and computed tomography in confirming the diagnosis pre-operatively. Salvage neck dissection may over-treat some of these patients.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Singapore General Hospital, Republic of Singapore. songtar@gmail.com
authors.forename: S-T
authors.initials: ST
authors.lastname: Toh
authors.forename: H-W
authors.initials: HW
authors.lastname: Yuen
authors.forename: K-H
authors.initials: KH
authors.lastname: Lim
authors.forename: Y-H
authors.initials: YH
authors.lastname: Goh
authors.forename: H-K C
authors.initials: HK
authors.lastname: Goh
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D009333:Neck; D037981:Neck Dissection; D009336:Necrosis; D018365:Neoplasm, Residual; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D012846:Singapore; D013997:Time Factors; D014057:Tomography, X-Ray Computed