Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study.
F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults.
Fiocco
A J
AJ
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA. afiocco@klaru-baycrest.on.ca
Kanaya
A M
AM
Lindquist
K M
KM
Harris
T B
TB
Satterfield
S
S
Simonsick
E M
EM
Kuller
L
L
Rosano
C
C
Yaffe
K
K
D000368:Aged; D015415:Biomarkers / Q000097:blood; D003071:Cognition; D015331:Cohort Studies; D003704:Dementia / Q000378:metabolism / Q000523:psychology; D056344:Executive Function; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male
D015415:Biomarkers; D028441:F2-Isoprostanes