title: Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus.
abstract: OBJECTIVE
  To determine the possible effect of corneal collagen crosslinking (CXL) with riboflavin and ultraviolet A (UVA) on intraocular pressure (IOP) measurements by Goldmann applanation tonometry (GAT).
  
  
  METHODS
  Institute of Vision and Optics, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  This noncomparative study measured IOP by GAT before CXL and 6 months and 12 months after CXL.
  
  
  RESULTS
  The study evaluated 55 eyes (55 patients). There was a statistically significant increase in the measured IOP 6 months and 12 months after CXL (both P<.001). The mean measured IOP was 9.95 mm Hg ± 3.01 (SD) before CXL, 11.40 ± 2.89 mm Hg at 6 months, and 11.35 ± 3.38 mm Hg at 12 months. The change in IOP measurements at both postoperative examinations was not correlated with patient age, preoperative pachymetry, or preoperative keratometry readings.
  
  
  CONCLUSIONS
  After riboflavin-UVA CXL in eyes with keratoconus, there was a significant increase in IOP measured by GAT that was probably caused by an increase in corneal rigidity.
authors.affiliation: Institute of Vision and Optics, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grentzelos
authors.forename: George A
authors.initials: GA
authors.lastname: Kounis
authors.forename: Dimitra M
authors.initials: DM
authors.lastname: Portaliou
authors.forename: Efstathios T
authors.initials: ET
authors.lastname: Detorakis
authors.forename: Michael
authors.initials: M
authors.lastname: Magarakis
authors.forename: Vasileios E
authors.initials: VE
authors.lastname: Karampatakis
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Pallikaris
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism*; D003432:Cross-Linking Reagents; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011446:Prospective Studies; D012256:Riboflavin / Q000627:therapeutic use*; D013997:Time Factors; D014065:Tonometry, Ocular; D014466:Ultraviolet Rays; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin