[Primary study of resting state functional magnetic resonance imaging in early onset schizophrenia using ReHo].
OBJECTIVE
To explore the regional homogeneity of resting state brain activity in early onset schizophrenia using functional magnetic resonance imaging.


METHODS
Schizophrenia or schizophreniform disorder was diagnosed according to DSM-IV-TR (diagnostic and statistical manual of mental disorders, fourth edition, text revision). A total of 18 adolescents with early-onset schizophrenia (EOS; onset of psychotic symptoms by age 18) and 18 age- and gender-matched healthy volunteers were tested in a resting-state fMRI scan. Regional homogeneity approach was used to analyze the functional imaging data,and statistical parametric mapping 5 (SPM5)was used to perform t-test in ReHo maps between the patients and controls.


RESULTS
In comparison with the controls, the early-onset patients showed significantly decreased regional homogeneity in bilateral medial prefrontal cortex(P<0.001,uncorrected; voxel>20), but no brain regions showed significantly increased regional homogeneity in the patients.


CONCLUSIONS
Regional homogeneity of resting state brain activities in EOS was decreased in bilateral medial prefrontal cortex. These abnormal changes may be involved in the psychopathology of schizophrenia.
Jiang
Shao'ai
S
Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, China.
Zhou
Bing
B
Liao
Yanhui
Y
Liu
Weiqing
W
Tan
Changlian
C
Chen
Xiaogang
X
Tang
Jinsong
J
D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult