[The dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa in the allergic rhinitis rat models].
OBJECTIVE
To investigate the dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rat models of allergic rhinitis, at different stages of the process during pathogenesis.


METHODS
One hundred and eighty Sprague-Dawley (SD) rats were randomly divided into three groups, the normal Group A used for contrast and experimental groups: Group B and C, each group were 60 rats. Then, observed the expression of the TGF-beta1 and FGF-2 in the nasal mucosa at different stages of the process by immunohistochemical staining.


RESULTS
The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of the normal Group A was negative, while the Group B and Group C were varying degrees of positive both, and Group B, the level of the TGF-beta1 and FGF-2 were both decline after allergen avoidance, but still more not ability than the expression of the Group B (P < 0.05).


CONCLUSIONS
The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rats models were varying degrees of positive , and it is decline while the allergen avoidance.
Xie
Bingbin
B
Department of Otorhinolaryngology, Foshan Hospital of Traditional Medicine, Foshan, 528000, China. linyun02@hotmail.com
Liu
Yuehui
Y
Luo
Gui
G
Liu
Jianguo
J
Zhong
Yanping
Y
Mei
Xiaofeng
X
D000818:Animals; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2