Antiinflammatory properties of Morus nigra leaves.
The aim of the present study was to investigate antiinflammatory activity of the methylene chloride extract of Morus nigra in animal models. Carrageenan-induced paw edema as well as fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the antiinflammatory activity of Morus nigra extract (MnE) in rats. A HPLC fingerprint was used for phytochemical analysis of the extracts. The MnE at test doses of 100-300 mg/kg p.o. clearly demonstrated antiinflammatory effects by reduced paw edema induced by carragenan and significantly inhibited the formation of granulomatous tissue. In addition, chemical compounds isolated from Morus nigra, including betulinic acid, β-sitosterol and germanicol, may be responsible for the antiinflammatory effect of the extract.
Padilha
Marina M
MM
Departamento de Farmácia, Laboratório de Plantas Medicinais e Fitoterápicos, Unifal-MG MG, Alfenas, Minas Gerais, Brazil.
Vilela
Fabiana C
FC
Rocha
Cláudia Q
CQ
Dias
Marcelo J
MJ
Soncini
Roseli
R
dos Santos
Marcelo H
MH
Alves-da-Silva
Geraldo
G
Giusti-Paiva
Alexandre
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy*; D008297:Male; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan