title: Isolation and crystal structure of marcanine A from Polyalthia plagioneura.
abstract: Marcanine A was isolated from the stems of Polyalthia plagioneura as light yellow crystals. The molecular and crystal structures have been determined by 1D,2D-NMR and X-ray diffraction analysis. It crystallizes in the triclinic system, space group P-1 with a = 5.2140(5)Å, b = 10.1871(11)Å, c = 11.0709(13)Å, α = 110.452(2)º, β = 103.376(2)°, γ = 90.1870(10)°, V = 533.74(10)A3, Z = 2. There are three intermolecular hydrogen bonds in a unit cell. It displays some inhibitory activities towards four kinds of human tumor cells, including BEL-7402, K562, SPCA-1 and SGC-7409.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Hainan, China.
authors.forename: Bingjing
authors.initials: B
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Guangying
authors.initials: G
authors.lastname: Chen
authors.forename: Changri
authors.initials: C
authors.lastname: Han
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans; D006860:Hydrogen Bonding; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D031044:Polyalthia / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; C530232:marcanine A