title: Progressive muscle weakness with respiratory insufficiency in a young patient with tetanus during magnesium sulfate infusion.
abstract: Magnesium sulfate administered as an intravenous infusion is considered safe. However, there have been concerns about the neuromuscular blocking properties of magnesium that can cause respiratory insufficiency. We report a patient with mild tetanus who, after being started on magnesium infusion, developed progressive respiratory insufficiency, proximal muscle weakness and ptosis. On discontinuation of magnesium infusion, the muscular weakness improved and respiration became normal. The safety of magnesium sulfate infusion for the management of tetanus needs to be re-evaluated.
authors.affiliation: Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India. tjpreethy@rediffmail.com
authors.forename: Preethy Joseph
authors.initials: PJ
authors.lastname: Mathew
authors.forename: Narayanan
authors.initials: N
authors.lastname: Muthurajan
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Wig
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced*; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D013742:Tetanus / Q000150:complications*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate