Profile of wound healing process induced by allantoin.
OBJECTIVE
To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods.


METHODS
Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model.


RESULTS
The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis.


CONCLUSIONS
This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin.
Araújo
Lorena Ulhôa
LU
Pharmacy School, UFOP, Ouro Preto, MG, Brazil.
Grabe-Guimarães
Andrea
A
Mosqueira
Vanessa Carla Furtado
VC
Carneiro
Claudia Martins
CM
Silva-Barcellos
Neila Márcia
NM
D000481:Allantoin / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology*; D004655:Emulsions; D005260:Female; D007090:Image Interpretation, Computer-Assisted; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D003879:Dermatologic Agents; D004655:Emulsions; D000481:Allantoin