title: Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection.
abstract: In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described, and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate toward the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer-initiating cells.
authors.affiliation: Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liège, Liège, Belgium.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Kroonen
authors.forename: Jessica
authors.initials: J
authors.lastname: Nassen
authors.forename: Yves-Gautier
authors.initials: YG
authors.lastname: Boulanger
authors.forename: Fabian
authors.initials: F
authors.lastname: Provenzano
authors.forename: Valérie
authors.initials: V
authors.lastname: Capraro
authors.forename: Vincent
authors.initials: V
authors.lastname: Bours
authors.forename: Didier
authors.initials: D
authors.lastname: Martin
authors.forename: Manuel
authors.initials: M
authors.lastname: Deprez
authors.forename: Pierre
authors.initials: P
authors.lastname: Robe
authors.forename: Bernard
authors.initials: B
authors.lastname: Rogister
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D002465:Cell Movement; D002552:Cerebral Ventricles / Q000473:pathology*; D003342:Corpus Striatum; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000473:pathology*; D009830:Olfactory Bulb; D014183:Transplantation, Heterologous