[Markers of chloric acid (I) in biological systems--identification and properties].
Reactive oxygen and nitrogen species are attributed to initiation and propagation of many diseases. The demonstration of elevated activity of myeloperoxidase and the level of 3-chlorotyrosine in atherosclerosis, kidney diseases and chronic inflammations brought about the interest in the biological role of another strong oxidant--hypochlorite. Concentration of this compound is extremely difficult to estimate in vivo and in vitro because of its high reactivity. The reaction of hypochlorite with biological compounds lead to formation of chlorohydrins, glutathione sulfonamides, chloramines, 3- and 3,5-dichlorotyrosines and chlorinated DNA bases (8-chloroadenine, 8-chloroguanine, 5-chlorocytosine and 5-chlorouracil). At least some of these products of hypochlorite action are believed to provide specific HOCl-biomarkers, useful especially in the analysis of clinical samples, using sensitive detection techniques.
Robaszkiewicz
Agnieszka
A
Katedra Biofizyki Molekulamrnej, Uniwersytet Łódzki, Łódź. agnieszka.robaszkiewicz@gmail.com
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002700:Chloramines / Q000737:chemistry / Q000302:isolation & purification; D002704:Chlorates / Q000737:chemistry* / Q000302:isolation & purification*; D002728:Chlorohydrins / Q000737:chemistry / Q000302:isolation & purification; D005978:Glutathione / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D006997:Hypochlorous Acid / Q000737:chemistry / Q000302:isolation & purification; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D013450:Sulfones / Q000737:chemistry / Q000302:isolation & purification
D015415:Biomarkers; D002700:Chloramines; D002704:Chlorates; D002728:Chlorohydrins; D013450:Sulfones; C430906:glutathione sulfonamide; D009249:NADP; D006997:Hypochlorous Acid; D005978:Glutathione; C022842:chloric acid