The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog.
The dog is a common model for study of osteoarthritis (OA). Subjective histologic scoring systems have often served as the reference standard for presence and severity of OA. However, these scoring systems have perceived shortcomings. The system developed for this report attempts to address these shortcomings by providing a standardized methodology for global assessment of the joint, versatility and the potential for relative weighting of pathology, allowing for comparison among time points, studies, and centers, and critical analysis of the system's reliability. The proposed system for assessment of canine tissues appears to provide an effective method for global assessment of articular pathology in OA. The system is versatile, comprehensive, and reliable and appears to have advantages over conventional scoring systems.
Cook
J L
JL
University of Missouri, Comparative Orthopaedic Laboratory, 900 East Campus Drive, Columbia, MO 65211, USA. cookjl@missouri.edu
Kuroki
K
K
Visco
D
D
Pelletier
J-P
JP
Schulz
L
L
Lafeber
F P J G
FP
D000818:Animals; D001169:Arthritis, Experimental / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D007596:Joints / Q000473:pathology; D008592:Menisci, Tibial / Q000473:pathology; D010003:Osteoarthritis / Q000473:pathology*; D012720:Severity of Illness Index; D013583:Synovial Membrane / Q000473:pathology