title: Use of Glubran 2 and Glubran tissue skin adhesive in patients with hereditary bleeding disorders undergoing circumcision and dental extraction.
abstract: Patients with bleeding disorders are at a high risk of bleeding complications during surgical procedures. Cyanoacrylates have been used successfully in many procedures and surgeries. This study was undertaken to evaluate the effectiveness of Glubran 2 and Glubran tissue skin adhesive (Glubran Tiss) in patients with hereditary bleeding disorders who underwent circumcision or dental extraction. Seven patients with congenital bleeding disorders who underwent circumcision or dental extraction were evaluated during 2009. A historical control group was considered for comparison. Glubran 2 acrylic glue was applied in cases of dental extraction and Glubran Tiss in circumcision. The patients were followed up for 6 months to detect complications. Five patients had hemophilia A, one patient had hemophilia B, and one patient had Bernard-Soulier syndrome; six were boys or men and one was a girl. Mean age was 15±8 years (range 5 to 25 years). The results in all patients under circumcision were good with significantly less factor consumption (P=0.043). But in patients who underwent dental extraction, Glubran was effective only in a 5-year-old girl with mandibular premolar tooth extraction, but not successful in a 21-year-old man with extraction of maxillary wisdom tooth. After 6 months of follow-up, no complications were observed in any patients. Our experiences in this small series of patients suggest that adjunct use of Glubran Tiss, in addition to systemic replacement therapy, can be effective in the control of bleeding in patients with hemophilia who undergo circumcision, and helps to lessen factor consumption. But, further studies with larger sample size are needed. However, our experience in using Glubran in dental extraction was not successful.
authors.affiliation: Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sezaneh
authors.initials: S
authors.lastname: Haghpanah
authors.forename: Armaghan
authors.initials: A
authors.lastname: Vafafar
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Golzadeh
authors.forename: Rezvan
authors.initials: R
authors.lastname: Ardeshiri
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
mesh_terms: D000293:Adolescent; D000328:Adult; D001606:Bernard-Soulier Syndrome / Q000150:complications*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D002944:Circumcision, Male / Q000009:adverse effects*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005260:Female; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications*; D006801:Humans; D008297:Male; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C421460:glubran; C421461:glubran 2