Synthesis and antioxidant activity of some new coumarinyl-1,3-thiazolidine-4-ones.
A series of Schiff's bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff's bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples.
Cacić
Milan
M
Department of Applied Chemistry and Ecology, Faculty of Food Technology, J. J. Strossmayer University, Franje Kuhaca 20, 31 000 Osijek, Croatia. mcacic@ptfos.hr
Molnar
Maja
M
Sarkanj
Bojan
B
Has-Schön
Elizabeta
E
Rajković
Valentina
V
D000447:Aldehydes / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry; D010084:Oxidation-Reduction; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry
D000447:Aldehydes; D000890:Anti-Infective Agents; D000975:Antioxidants; D053778:Thiazolidines; D008982:Molybdenum; D001205:Ascorbic Acid