title: Successful thrombolytic therapy for recurrent right ventricular thrombosis in Behçet's disease.
abstract: Behçet's disease (BD) is a chronic inflammatory multisystem disorder characterised by recurrent oral and genital aphtosis and ocular involvement. Thrombophlebitis and major vessel thrombosis are common manifestations of vascular involvement in BD patients, whereas intracardiac thrombosis is extremely rare. We describe a 22-year-old woman who presented with deep vein thrombosis and recurrent right ventricular thrombosis complicated by pulmonary embolism. At the time, she complained of fever, recurrent painful oral and genital aphtae and papulo-pustular skin rash so she was diagnosed with BD. She received intravenous streptokinase 50,000 units/hour for three days plus corticosteroids with complete recovery. A review of intracardiac thrombosis in BD is presented and the use of thrombolytic therapy in this rare condition is briefly discussed.
authors.affiliation: University of Cagliari, Cagliari, Italy. matteopiga@alice.it
authors.forename: Matteo
authors.initials: M
authors.lastname: Piga
authors.forename: Francesc
authors.initials: F
authors.lastname: Puchades
authors.forename: Isabel
authors.initials: I
authors.lastname: Mayo
authors.forename: David
authors.initials: D
authors.lastname: D'Cruz
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001528:Behcet Syndrome / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006331:Heart Diseases / Q000150:complications / Q000188:drug therapy*; D006352:Heart Ventricles; D006801:Humans; D011655:Pulmonary Embolism / Q000209:etiology; D012008:Recurrence; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D005343:Fibrinolytic Agents; D013300:Streptokinase