The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells.
Stem cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells. These cells are relatively easy to obtain, appear to be pluripotent, and are immunologically immature. These cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells.
Sanberg
Paul R
PR
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA. psanberg@health.usf.edu
Eve
David J
DJ
Willing
Alison E
AE
Garbuzova-Davis
Svitlana
S
Tan
Jun
J
Sanberg
Cyndy D
CD
Allickson
Julie G
JG
Cruz
L Eduardo
LE
Borlongan
Cesar V
CV
D053687:Adult Stem Cells / Q000166:cytology* / Q000637:transplantation; D001773:Blood Cells / Q000166:cytology*; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation