title: A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes.
abstract: A novel nucleoside analog with a disulfide bridge structure at the sugar moiety, which shows redox-responsive reversibility of the sugar conformation due to formation and scission of the disulfide bond, was designed and synthesized.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Baba
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kodama
authors.forename: Kazuto
authors.initials: K
authors.lastname: Mori
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D002241:Carbohydrates; D009705:Nucleosides