title: Adjustment and characterization of an original model of chronic ischemic heart failure in pig.
abstract: We present and characterize an original experimental model to create a chronic ischemic heart failure in pig. Two ameroid constrictors were placed around the LAD and the circumflex artery. Two months after surgery, pigs presented a poor LV function associated with a severe mitral valve insufficiency. Echocardiography analysis showed substantial anomalies in radial and circumferential deformations, both on the anterior and lateral surface of the heart. These anomalies in function were coupled with anomalies of perfusion observed in echocardiography after injection of contrast medium. No demonstration of myocardial infarction was observed with histological analysis. Our findings suggest that we were able to create and to stabilize a chronic ischemic heart failure model in the pig. This model represents a useful tool for the development of new medical or surgical treatment in this field.
authors.affiliation: Inserm U 828, Avenue du Haut-Lévêque, 33600 Pessac, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Barandon
authors.forename: Joachim
authors.initials: J
authors.lastname: Calderon
authors.forename: Patricia
authors.initials: P
authors.lastname: Réant
authors.forename: Dominique
authors.initials: D
authors.lastname: Caillaud
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lafitte
authors.forename: Xavier
authors.initials: X
authors.lastname: Roques
authors.forename: Thierry
authors.initials: T
authors.lastname: Couffinhal
authors.forename: Pierre
authors.initials: P
authors.lastname: Dos Santos