title: Hypertension, nitric oxide, oxidants, and dietary plant polyphenols.
abstract: Fruits and vegetables are key foods whose high ingestion is associated with the improvement of numerous pathological conditions, including hypertension. Such health promoting actions have been increasingly ascribed to the antioxidant characteristics of different polyphenols in fruits and vegetables. Consequently, based on this assumption, many beverages and foods rich in polyphenols, grape, tea, cocoa, and soy products and many of their chemical constituents purified, are being studied both, as antioxidants and antihypertensive agents. This paper reviews the current evidence linking high polyphenol consumption with reductions in blood pressure. Basic chemical aspects of flavanols, flavonols, isoflavones and stilbenes, as possible responsible for the observed effects of those foods on blood pressure are included. Human interventions studies by using grapes and wine, cocoa and chocolate, black and green tea, soy products, and purified compounds ((+)-catequin, quercetin, (-)-epigallocatechin gallate) are summarized. The discussed hypothesis, strongly supported by experimental data in animals, is that by regulating nitric oxide bioavailability, polyphenols present in fruits and vegetables affect endothelial function and as a consequence, blood pressure. Even when data are not definitive and many questions remain open, the whole evidence is encouraging to start considering diets that can provide a benefit to hypertensive subjects, and those benefits will be more significant in people that do not have controlled his/her elevated blood pressure.
authors.affiliation: Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956 C1113AAD, Buenos Aires, Argentina.
authors.forename: Monica
authors.initials: M
authors.lastname: Galleano
authors.forename: Olga
authors.initials: O
authors.lastname: Pechanova
authors.forename: Cesar G
authors.initials: CG
authors.lastname: Fraga
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002318:Cardiovascular Diseases / Q000178:diet therapy / Q000188:drug therapy; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000188:drug therapy*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D028321:Plant Preparations / Q000378:metabolism / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D011918:Rats, Inbred SHR; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D016877:Oxidants; D010636:Phenols; D028321:Plant Preparations; D059808:Polyphenols; D017382:Reactive Oxygen Species; D009569:Nitric Oxide