Genetic aberrations in gallbladder cancer.
Gallbladder carcinoma (GBC) is the most common type of biliary tract carcinoma and the third commonest digestive tract malignancy in our region. Studies available in literature do not clearly define the molecular genetic mechanisms involved in the pathogenesis of GBC. Most of these studies are limited to protein expression analysis by immunohistochemistry and western blotting, and only a few have been done on mRNA (messenger RNA) and mutation analysis. This review aims to critically analyze all the available evidence on genetic aberrations in gallbladder carcinoma.
Maurya
Sanjeev K
SK
Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Tewari
Mallika
M
Mishra
Raghvendra R
RR
Shukla
Hari S
HS
D042501:Angiogenic Proteins / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics; D020169:Caspases / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D005706:Gallbladder Neoplasms / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D053842:Microsatellite Instability; D009077:Mucins / Q000378:metabolism; D009857:Oncogenes / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000378:metabolism; D017463:Receptors, Complement 3b / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism
D042501:Angiogenic Proteins; C509991:CR1 protein, human; D015815:Cell Adhesion Molecules; D018797:Cell Cycle Proteins; D009077:Mucins; D011956:Receptors, Cell Surface; D017463:Receptors, Complement 3b; D019098:Telomerase; D020169:Caspases