Gout: a clinical syndrome illustrated and discussed.
Gout is an acute inflammatory arthritis with the potency to fully destroy the integrity of the joint leading to severe disability. Besides joint destruction, gout is often associated with an accelerated atherosclerosis culminating in an increased risk of cardiovascular disease. The current existing therapy modalities allow an efficient treatment that not only controls local inflammation but might also have an effect on the generalised features that surround this condition. Here we discuss the modes of clinical appearance, how we are nowadays supposed to treat gout and the current knowledge about the pathogenesis of this clinical syndrome.
Bhansing
K J
KJ
Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
van Bon
L
L
Janssen
M
M
Radstake
T R D J
TR
D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006073:Gout / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia; D008297:Male; D012307:Risk Factors; D014481:United States; D014527:Uric Acid / Q000037:antagonists & inhibitors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006074:Gout Suppressants; D014527:Uric Acid; D000493:Allopurinol