title: Organ preservation surgery for advanced hypopharyngeal cancer.
abstract: CONCLUSIONS
  Organ preservation surgery with partial pharyngectomy preserving the larynx is feasible for the treatment of advanced hypopharyngeal cancer with comparable local control and preservation of function.
  
  
  OBJECTIVE
  To examine the feasibility and therapeutic effects of organ preservation surgery for advanced hypopharyngeal cancer.
  
  
  METHODS
  Fourteen patients with stage III/IV hypopharyngeal cancer were treated by partial pharyngectomy with or without partial laryngectomy to preserve the larynx. Ten cases were T1/2 primary while four cases had T3/4 tumors. Reconstruction of the pharyngolarynx was completed by primary mucosal suture in six, while free forearm flap was used in eight cases. Induction chemotherapy was administered for six cases including three with T3/4 tumors.
  
  
  RESULTS
  Five-year overall survival and disease-specific survival rates were 57.1% and 66.7%, respectively. The 5-year locoregional control rate was 66.7% and the larynx preservation rate was 100%. No patients presented with local recurrence at the pharyngolaryngeal segment, while two cases showed nodal recurrence, from which they died. Tracheal stoma was closed in 9 of 14 cases. Vocal function was excellent in five cases, moderate in five, and poor in three. Swallowing function was excellent to moderate in eight cases and poor in six.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Kyoto University, Kyoto, Japan. hirano@ent.kuhp.kyoto-u.ac.jp
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hirano
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tateya
authors.forename: Morimasa
authors.initials: M
authors.lastname: Kitamura
authors.forename: Shinpei
authors.initials: S
authors.lastname: Kada
authors.forename: Seiji
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kanda
authors.forename: Shinzo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D010611:Pharyngectomy; D012189:Retrospective Studies; D013524:Surgical Flaps; D015996:Survival Rate; D016896:Treatment Outcome