Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection.
In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described, and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate toward the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer-initiating cells.
Kroonen
Jérôme
J
Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liège, Liège, Belgium.
Nassen
Jessica
J
Boulanger
Yves-Gautier
YG
Provenzano
Fabian
F
Capraro
Valérie
V
Bours
Vincent
V
Martin
Didier
D
Deprez
Manuel
M
Robe
Pierre
P
Rogister
Bernard
B
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D002465:Cell Movement; D002552:Cerebral Ventricles / Q000473:pathology*; D003342:Corpus Striatum; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000473:pathology*; D009830:Olfactory Bulb; D014183:Transplantation, Heterologous