Synthesis and antifungal activity of carabrone derivatives.
Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
Feng
Jun-Tao
JT
Research and Development Center of Biorational Pesticide, College of Plant Protection, Northwest A&F University, Yangling, China. fengjt67@hotmail.com
Ma
Zhi-Qing
ZQ
Li
Jiang-Hua
JH
He
Jun
J
Xu
Hui
H
Zhang
Xing
X
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D020231:Colletotrichum / Q000187:drug effects; D007783:Lactones; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D007783:Lactones; D012717:Sesquiterpenes