Survival after diphenhydramine ingestion with hemodialysis in a toddler.
A 13-month-old male who ingested 20 diphenhydramine (25 mg) tablets presented with seizures and ultimately progressed to status epilepticus and wide-complex tachycardia. Due to worsening clinical course, hemodialysis was performed with temporal resolution of his symptoms. Hemodialysis may be considered in critically ill diphenhydramine overdoses not responsive to conventional supportive care.
McKeown
Nathanael J
NJ
Department of Emergency Medicine, Oregon Health & Science University, Oregon Poison Center, 3181 SW Sam Jackson Park Rd., Mail Code CB550, Portland, OR 97239, USA. mckeownn@ohsu.edu
West
Patrick L
PL
Hendrickson
Robert G
RG
Horowitz
B Zane
BZ
D004155:Diphenhydramine / Q000506:poisoning*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning* / Q000627:therapeutic use; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D011041:Poisoning / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006435:Renal Dialysis; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D013226:Status Epilepticus / Q000139:chemically induced; D013610:Tachycardia / Q000139:chemically induced / Q000503:physiopathology; D016896:Treatment Outcome
D006993:Hypnotics and Sedatives; D004155:Diphenhydramine; D008874:Midazolam