Epithelial-to-mesenchymal transition in pancreatic adenocarcinoma.
Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/ aggressiveness, and the drug resistance of pancreatic cancer cells.
Cano
Carla E
CE
INSERM U624 Cell Stress, Biology of Pancreas Stress Laboratory, Marseille, France. carla.cano@inserm.fr
Motoo
Yoshiharu
Y
Iovanna
Juan L
JL
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000378:metabolism / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051785:Smad Proteins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
D035683:MicroRNAs; D051785:Smad Proteins; D016212:Transforming Growth Factor beta