title: Pharmacogenomics--practice and challenges.
abstract: BACKGROUND
  Generating revenue of over $1 billion annually to owner companies, blockbuster drugs have been a prominent feature of drug development over recent decades. However, a large number of patients have an inadequate therapeutic response to the 'one size fits all' blockbuster drugs. It is difficult to predict which patient subgroups will respond well to a drug and which will have significant adverse reactions.
  
  
  OBJECTIVE
  This article outlines the potential role of pharmacogenomics in drug development and personalised medicine in order to examine possible treatment strategies targeted to patients according to their genetic profile.
  
  
  CONCLUSIONS
  Drug development based on pharmacogenomics has the potential to result in medications that have predictable responses in ethnic or racial patient subpopulations and can be targeted to accommodate individual genetic variation. The key challenges for the successful implementation of this concept include finding suitable biomarkers, bringing down the cost of laboratory investigations, and making drug development processes based on pharmacogenomics economically viable for pharmaceutical companies.
authors.affiliation: Maulana Azad Medical College, New Delhi, India. dr.raktimghosh@yahoo.co.in
authors.forename: Raktim
authors.initials: R
authors.lastname: Ghosh
authors.forename: Samhati
authors.initials: S
authors.lastname: Ghosh
authors.forename: Shalini
authors.initials: S
authors.lastname: Chawla
mesh_terms: D001315:Australia; D004345:Drug Industry; D017850:Economics, Pharmaceutical; D006801:Humans; D010597:Pharmacogenetics; D057285:Precision Medicine