Sympathetic and cardiovascular responses to glossopharyngeal insufflation in trained apnea divers.
Glossopharyngeal insufflation (lung packing) is a common maneuver among experienced apnea divers by which additional air is pumped into the lungs. It has been shown that packing may compromise cardiovascular homeostasis. We tested the hypothesis that the packing-mediated increase in intrathoracic pressure enhances the baroreflex-mediated increase in muscle sympathetic nerve activity (MSNA) in response to an exaggerated drop in cardiac output (CO). We compared changes in hemodynamics and MSNA (peroneal microneurography) during maximal breath-holds without and with prior moderate packing (0.79 ± 0.40 liters) in 14 trained divers (12 men, 2 women, 26.7 ± 4.5 yr, body mass index 24.8 ± 2.4 kg/m(2)). Packing did not change apnea time (3.8 ± 1.0 vs. 3.8 ± 1.2 min), hemoglobin oxygen desaturation (-17.6 ± 12.3 vs. -18.7 ± 12.8%), or the reduction in CO (1 min: -3.65 ± 1.83 vs. -3.39 ± 1.96 l/min; end of apnea: -2.44 ± 1.33 vs. -2.16 ± 1.44 l/min). On the other hand, packing dampened the early, i.e., 1-min increase in mean arterial pressure (MAP, 1 min: 9.2 ± 8.3 vs. 2.4 ± 11.0 mmHg, P < 0.01) and in total peripheral resistance (relative TPR, 1 min: 2.1 ± 0.5 vs. 1.9 ± 0.5, P < 0.05) but it augmented the concomitant rise in MSNA (1 min: 28.0 ± 11.7 vs. 39.4 ± 12.7 bursts/min, P < 0.001; 32.8 ± 16.4 vs. 43.9 ± 14.8 bursts/100 heart beats, P < 0.01; 3.3 ± 2.1 vs. 4.8 ± 3.2 au/min, P < 0.05). We conclude that the early sympathoactivation 1 min into apnea after moderate packing is due to mechanisms other than excessive reduction in CO. We speculate that lower MAP despite increased MSNA after packing might be explained by vasodilator substances released by the lungs. This idea should be addressed in future studies.
Heusser
Karsten
K
Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. karsten.heusser@gmx.de
Dzamonja
Gordan
G
Breskovic
Toni
T
Steinback
Craig D
CD
Diedrich
André
A
Tank
Jens
J
Jordan
Jens
J
Dujic
Zeljko
Z
D000328:Adult; D001049:Apnea / Q000503:physiopathology*; D017704:Baroreflex; D001794:Blood Pressure; D002302:Cardiac Output; D002319:Cardiovascular System / Q000294:innervation*; D018592:Cross-Over Studies; D004242:Diving; D005260:Female; D005930:Glossopharyngeal Nerve / Q000503:physiopathology*; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007327:Insufflation; D008297:Male; D010543:Peroneal Nerve / Q000503:physiopathology; D011446:Prospective Studies; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors; D014664:Vasodilation; D055815:Young Adult