title: The diagnosis and management of prosthetic joint infections.
abstract: A host of technical and operative improvements have seen the rates of infection associated with joint replacement reach historic lows. However, the increasing number of operations being performed means that the absolute number of such infections remains significant. Diagnosis may be challenging and delaying appropriate treatment can lead to reduced joint function and the need for more complex, perhaps multiple, procedures. Individual centres tend to see small numbers of such cases, and in the absence of large clinical trials management varies. Early diagnosis, selection of an appropriate surgical strategy, accurate identification of the responsible microorganisms and construction of an appropriate antibiotic regimen are essential elements of any management strategy. Such packages of care are best delivered by a multidisciplinary team composed of orthopaedic and plastic surgeons, microbiologists, infectious disease physicians, specialist nurses, physiotherapists and occupational therapists. Each treatment plan must be developed in consultation with the patient, taking into account their aims and realistic goals. This review provides an overview of current understanding regarding diagnosis and treatment of prosthetic joint infections and suggests a treatment algorithm.
authors.affiliation: Department of Microbiology and Infectious Disease, John Radcliffe Hospital, Oxford OX3 9DU, UK. edward.moran@imm.ox.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Moran
authors.forename: I
authors.initials: I
authors.lastname: Byren
authors.forename: B L
authors.initials: BL
authors.lastname: Atkins
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D013514:Surgical Procedures, Operative / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents