title: Aqueous humor nitric oxide in patients with central retinal vein occlusion.
abstract: OBJECTIVE
  It has been suggested that nitric oxide (NO) has a role in ischemic retinopathies. Since retinal ischemia may develop in retinal vein occlusion, we investigated the presence of nitric oxide in the pathogenesis of central retinal vein occlusion (CRVO).
  
  
  METHODS
  Eighteen consecutive patients with CRVO were included in this study. Aqueous humor specimens were obtained within 21 days of diagnosis. Samples of aqueous humor were also collected from 20 control patients undergoing cataract surgery. For each sample after reduction of nitrate to nitrite with vanadium chloride (VCl(3)), we used spectrophotometric method for simultaneous detection of nitrate and nitrite (NO(x)).
  
  
  RESULTS
  Mean level of aqueous humor NO(x) in CRVO and control group was 94.1±23.2 μmol/l and 55.6±11.0 μmol/l, respectively. The difference between two groups was statistically significant (p<0.0001).
  
  
  CONCLUSIONS
  Our results may support involvement of nitric oxide in the pathogenesis of CRVO.
authors.affiliation: Farabi Eye Research Center, Department of Neuroophthalmology, Tehran University of Medical Sciences, Tehran, Iran. masood219@gmail.com
authors.forename: Masoud Aghsaei
authors.initials: MA
authors.lastname: Fard
authors.forename: Alireza
authors.initials: A
authors.lastname: Lashey
authors.forename: Ahmad-Reza
authors.initials: AR
authors.lastname: Dehpour
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism*; D012170:Retinal Vein Occlusion / Q000378:metabolism* / Q000473:pathology
chemical_list: D009569:Nitric Oxide