title: Impact of executive function deficits in youth with bipolar I disorder: a controlled study.
abstract: Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond those predicted by having BP-I disorder. Youth with BP-I disorder were ascertained from psychiatric clinics and community sources. We defined EFDs as having at least two out of eight EF measures impaired from a battery of six tests. Significantly more youth with BP-I disorder had EFDs than controls (45% versus 17%). Comparisons were made between controls without EFDs (N=81), controls with EFDs (N=17), BP-I youth without EFDs (N=76), and BP-I youth with EFDs (N=62). EFDs were associated with an increased risk for placement in a special class and a decrease in academic achievement (WRAT-3 reading and arithmetic). EFDs in BP-I subjects were associated with an increased risk for speech/language disorder (as assessed in the K-SADS-E) relative to BP-I subjects without EFDs. Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning.
authors.affiliation: Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA. jbiederman@partners.org
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
authors.forename: Carter R
authors.initials: CR
authors.lastname: Petty
authors.forename: Janet
authors.initials: J
authors.lastname: Wozniak
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Wilens
authors.forename: Ronna
authors.initials: R
authors.lastname: Fried
authors.forename: Alysa
authors.initials: A
authors.lastname: Doyle
authors.forename: Aude
authors.initials: A
authors.lastname: Henin
authors.forename: Clancey
authors.initials: C
authors.lastname: Bateman
authors.forename: Maggie
authors.initials: M
authors.lastname: Evans
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D001714:Bipolar Disorder / Q000150:complications* / Q000523:psychology; D016009:Chi-Square Distribution; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D009483:Neuropsychological Tests; D011593:Psychology, Social