title: Cytogenetic instability in childhood acute lymphoblastic leukemia survivors.
abstract: Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.
authors.affiliation: Departamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14040-901 São Paulo, Brazil. solbrassesco@hotmail.com
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Danilo Jordão
authors.initials: DJ
authors.lastname: Xavier
authors.forename: Marjori Leiva
authors.initials: ML
authors.lastname: Camparoto
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Montaldi
authors.forename: Paulo Roberto D'Auria Vieira
authors.initials: PR
authors.lastname: de Godoy
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Scrideli
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
authors.forename: Elza Tiemi
authors.initials: ET
authors.lastname: Sakamoto-Hojo
mesh_terms: D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D015331:Cohort Studies; D015897:Comorbidity; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D017741:Survivors / Q000706:statistics & numerical data*