title: Complete valvular heart apparatus model from 4D cardiac CT.
abstract: The cardiac valvular apparatus, composed of the aortic, mitral, pulmonary and tricuspid valve, is an essential part of the anatomical, functional and hemodynamic mechanism of the heart and the cardiovascular system as a whole. Valvular heart diseases often involve multiple dysfunctions and require joint assessment and therapy of the valves. In this paper, we propose a complete and modular patient-specific model of the cardiac valvular apparatus estimated from 4D cardiac CT data. A new constrained Multi-linear Shape Model (cMSM), conditioned by anatomical measurements, is introduced to represent the complex spatiotemporal variation of the heart valves. The cMSM is exploited within a learning-based framework to efficiently estimate the patient-specific valve parameters from cine images. Experiments on 64 4D cardiac CT studies demonstrate the performance and clinical potential of the proposed method. To the best of our knowledge, it is the first time cardiologists and cardiac surgeons can benefit from an automatic quantitative evaluation of the complete valvular apparatus based on non-invasive imaging techniques. In conjunction with existent patient-specific chamber models, the presented valvular model enables personalized computation modeling and realistic simulation of the entire cardiac system.
authors.affiliation: Computer Aided Medical Procedures, Technical University Munich, Germany.
authors.forename: Sasa
authors.initials: S
authors.lastname: Grbić
authors.forename: Razvan
authors.initials: R
authors.lastname: Ionasec
authors.forename: Dime
authors.initials: D
authors.lastname: Vitanovski
authors.forename: Ingmar
authors.initials: I
authors.lastname: Voigt
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Bogdan
authors.initials: B
authors.lastname: Georgescu
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
authors.forename: Dorin
authors.initials: D
authors.lastname: Comaniciu
mesh_terms: D000465:Algorithms; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D006351:Heart Valves / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*