title: VEGF receptor signaling in vertebrate development.
abstract: The secreted glycoprotein vascular endothelial growth factor A (VEGF or VEGFA) affects many different cell types and modifies a wide spectrum of cellular behaviors in tissue culture models, including proliferation, migration, differentiation and survival. The versatility of VEGF signaling is reflected in the complex composition of its cell surface receptors and their ability to activate a variety of different downstream signaling molecules. A major challenge for VEGF research is to determine which of the specific signaling pathways identified in vitro control development and homeostasis of tissues containing VEGF-responsive cell types in vivo.
authors.affiliation: UCL Institute of Ophthalmology, University College London, London, UK.
authors.forename: Joaquim Miguel
authors.initials: JM
authors.lastname: Vieira
authors.forename: Christiana
authors.initials: C
authors.lastname: Ruhrberg
authors.forename: Quenten
authors.initials: Q
authors.lastname: Schwarz
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D014714:Vertebrates / Q000196:embryology* / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D040262:Receptors, Vascular Endothelial Growth Factor