Physiologic and pathologic changes of platelets in pregnancy.
Platelets are key players in haemostasis and thrombus formation. Defects affecting platelets during pregnancy can lead to heterogeneous complications, such as thrombosis, first trimester miscarriage and postpartum haemorrhage. The incidence of complications is increased in women who have heritable platelet function disorders. Modifications of platelet count or platelet functions during normal pregnancy and preeclampsia will be summarized and the management of pregnant women with heritable platelet function disorders will be discussed.
Valera
Marie-Cecile
MC
INSERM U858, I2MR, Equipe 9, CHU Rangueil, BP 84225, 31432 Toulouse cedex 4, France.
Parant
Olivier
O
Vayssiere
Christophe
C
Arnal
Jean-François
JF
Payrastre
Bernard
B
D001606:Bernard-Soulier Syndrome / Q000097:blood; D001791:Blood Platelet Disorders / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D011250:Pregnancy Complications, Hematologic; D013921:Thrombocytopenia / Q000097:blood