title: p38(MAPK) in the senescence of human and murine fibroblasts.
abstract: Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38(MAPK) pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-relatedpathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.
authors.affiliation: University of Namur, Research Unit on Cellular Biology, Rue de Bruxelles, 61, Namur B-5000, Belgium. florence.chainiaux@fundp.ac.be
authors.forename: Florence
authors.initials: F
authors.lastname: Debacq-Chainiaux
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Boilan
authors.forename: Jérémie
authors.initials: J
authors.lastname: Dedessus Le Moutier
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Weemaels
authors.forename: Olivier
authors.initials: O
authors.lastname: Toussaint
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D005347:Fibroblasts / Q000201:enzymology*; D006801:Humans; D051379:Mice; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D048051:p38 Mitogen-Activated Protein Kinases