title: Malignant peripheral nerve sheath tumour in the liver of a dog.
abstract: A 14-year-old male mixed breed dog was presented for abdominal distension and abdominal pain. Radiographical examination identified a large space-occupying mass in the abdomen. Necropsy examination revealed the presence of a 12cm hepatic mass that occupied almost half of the abdominal cavity. Microscopically, this mass consisted of spindle-shaped neoplastic cells that were arranged in short streams and interlacing bundles. Immunohistochemically, the neoplastic cells expressed vimentin, S-100, protein gene product 9.5 and neuron specific enolase, but were negative for cytokeratin, smooth muscle actin, melan A and von Willebrand Factor. These findings indicated that the hepatic mass was a primary hepatic peripheral nerve sheath tumour. To our knowledge, this is the first documentation of a primary hepatic malignant peripheral nerve sheath tumour in a dog.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
authors.forename: J-W
authors.initials: JW
authors.lastname: Park
authors.forename: G-H
authors.initials: GH
authors.lastname: Woo
authors.forename: H
authors.initials: H
authors.lastname: Jee
authors.forename: D-W
authors.initials: DW
authors.lastname: Jung
authors.forename: H-Y
authors.initials: HY
authors.lastname: Youn
authors.forename: M-C
authors.initials: MC
authors.lastname: Choi
authors.forename: D-Y
authors.initials: DY
authors.lastname: Kim
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase