Aqueous humor nitric oxide in patients with central retinal vein occlusion.
OBJECTIVE
It has been suggested that nitric oxide (NO) has a role in ischemic retinopathies. Since retinal ischemia may develop in retinal vein occlusion, we investigated the presence of nitric oxide in the pathogenesis of central retinal vein occlusion (CRVO).


METHODS
Eighteen consecutive patients with CRVO were included in this study. Aqueous humor specimens were obtained within 21 days of diagnosis. Samples of aqueous humor were also collected from 20 control patients undergoing cataract surgery. For each sample after reduction of nitrate to nitrite with vanadium chloride (VCl(3)), we used spectrophotometric method for simultaneous detection of nitrate and nitrite (NO(x)).


RESULTS
Mean level of aqueous humor NO(x) in CRVO and control group was 94.1±23.2 μmol/l and 55.6±11.0 μmol/l, respectively. The difference between two groups was statistically significant (p<0.0001).


CONCLUSIONS
Our results may support involvement of nitric oxide in the pathogenesis of CRVO.
Fard
Masoud Aghsaei
MA
Farabi Eye Research Center, Department of Neuroophthalmology, Tehran University of Medical Sciences, Tehran, Iran. masood219@gmail.com
Lashey
Alireza
A
Dehpour
Ahmad-Reza
AR
D000368:Aged; D001082:Aqueous Humor / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism*; D012170:Retinal Vein Occlusion / Q000378:metabolism* / Q000473:pathology
D009569:Nitric Oxide