Cytogenetic instability in childhood acute lymphoblastic leukemia survivors.
Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.
Brassesco
María Sol
MS
Departamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14040-901 São Paulo, Brazil. solbrassesco@hotmail.com
Xavier
Danilo Jordão
DJ
Camparoto
Marjori Leiva
ML
Montaldi
Ana Paula
AP
de Godoy
Paulo Roberto D'Auria Vieira
PR
Scrideli
Carlos Alberto
CA
Tone
Luiz Gonzaga
LG
Sakamoto-Hojo
Elza Tiemi
ET
D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D015331:Cohort Studies; D015897:Comorbidity; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D017741:Survivors / Q000706:statistics & numerical data*