title: [Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome].
abstract: We investigated the association of polymorphisms of genes FGB G(-455)A and PROCC(-1654)T with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 1.14 +/- +/- 0.33 years (the maximum term 3.2 years). The group studied do not differ significantly with respect to the distributions of G(-455)A alleles and genotypes. However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles. Survival time from end point from carrier phenotype TT and CTis 2.19 +/- 0.18 r. years against 2.46 +/- 0.16 from carrier phenotype CCgene PROC. The obtained data allows to assume the important role of the genes which are responsible for functioning of system of a hemostasis, in the accelerated formation of failures at the patients who had a coronary syndrome.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Agapkina
authors.forename: A G
authors.initials: AG
authors.lastname: Nikitin
authors.forename: A N
authors.initials: AN
authors.lastname: Brovkin
authors.forename: A A
authors.initials: AA
authors.lastname: Pushkov
authors.forename: M A
authors.initials: MA
authors.lastname: Evdokimova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Kudriashova
authors.forename: V S
authors.initials: VS
authors.lastname: Osmolovskaia
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
authors.forename: M S
authors.initials: MS
authors.lastname: Kochkina
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.forename: E N
authors.initials: EN
authors.lastname: Dankovtseva
authors.forename: O S
authors.initials: OS
authors.lastname: Chumakova
authors.forename: T N
authors.initials: TN
authors.lastname: Baklanova
authors.forename: P A
authors.initials: PA
authors.lastname: Talyzin
authors.forename: N E
authors.initials: NE
authors.lastname: Reznichenko
authors.forename: O P
authors.initials: OP
authors.lastname: Donetskaia
authors.forename: S N
authors.initials: SN
authors.lastname: Tereshchenko
authors.forename: E S
authors.initials: ES
authors.lastname: Krasil'nikova
authors.forename: N A
authors.initials: NA
authors.lastname: Dzhaiani
authors.forename: E V
authors.initials: EV
authors.lastname: Akatova
authors.forename: M G
authors.initials: MG
authors.lastname: Glezer
authors.forename: A S
authors.initials: AS
authors.lastname: Galiavich
authors.forename: V B
authors.initials: VB
authors.lastname: Zakirova
authors.forename: N A
authors.initials: NA
authors.lastname: Kaziolova
authors.forename: I V
authors.initials: IV
authors.lastname: Timofeeva
authors.forename: A V
authors.initials: AV
authors.lastname: Iagoda
authors.forename: O I
authors.initials: OI
authors.lastname: Boeva
authors.forename: L I
authors.initials: LI
authors.lastname: Katel'nitskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Khorolets
authors.forename: S V
authors.initials: SV
authors.lastname: Shlyk
authors.forename: É G
authors.initials: ÉG
authors.lastname: Volkova
authors.forename: M P
authors.initials: MP
authors.lastname: Margarian
authors.forename: I O
authors.initials: IO
authors.lastname: Guz'
authors.forename: V O
authors.initials: VO
authors.lastname: Konstantinov
authors.forename: A N
authors.initials: AN
authors.lastname: Timofeeva
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshchikiov
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000401:mortality*; D000483:Alleles; D018572:Disease-Free Survival; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011486:Protein C / Q000235:genetics*; D012426:Russia / Q000453:epidemiology; D015996:Survival Rate
chemical_list: D011486:Protein C; D005340:Fibrinogen