title: Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response.
abstract: The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.
authors.affiliation: Novartis Institutes of BioMedical Research, Neuropsychiatry, GPCR Expertise Program, Basel, Switzerland. markus.fendt@novartis.com
authors.forename: Markus
authors.initials: M
authors.lastname: Fendt
authors.forename: Mélanie
authors.initials: M
authors.lastname: Buchi
authors.forename: Hugo
authors.initials: H
authors.lastname: Bürki
authors.forename: Stefan
authors.initials: S
authors.lastname: Imobersteg
authors.forename: Bérangère
authors.initials: B
authors.lastname: Ricoux
authors.forename: Thomas
authors.initials: T
authors.lastname: Suply
authors.forename: Andreas W
authors.initials: AW
authors.lastname: Sailer
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D046353:Immobility Response, Tonic / Q000187:drug effects / Q000502:physiology; D057967:Infusions, Intraventricular; D007266:Inhibition, Psychological; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013216:Reflex, Startle / Q000187:drug effects / Q000235:genetics* / Q000502:physiology
chemical_list: C515062:NPSR1 protein, mouse; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; C539972:neuropeptide S, mouse; D003042:Cocaine