Monocyte chemoattractant protein (MCP-1) A-2518G gene polymorphism in stroke patients with different comorbidities.
OBJECTIVE
The aim of our study was to assess the effect of A-2518G polymorphism in the monocyte chemoattractant protein-1 gene on development of stroke.


METHODS
A total of 194 patients with stroke and 320 healthy controls were genotyped for the MCP-1 gene -2518 polymorphism.


RESULTS
There was a significant difference in genotype frequencies between ischemic stroke patients and controls (p=0.01). Stroke patients were subdivided according to gender, presence of renal disease, small-vessel disease, diabetes, atherosclerosis and hyperlipidemia. There were differences in genotype frequencies between stroke patients with atherosclerosis and controls (p=0.03), and in allele frequencies between diabetic patients and controls (p=0.04). In hyperlipidemia, the OR 2.33 for the GG genotype may be due to stroke, because it was found only vs. controls and not vs. group without hyperlipidemia.


CONCLUSIONS
Our results demonstrate an association between the polymorphism in the regulatory region of MCP-1 gene and susceptibility to ischemic stroke.
Buraczynska
Kinga
K
Department of Neurology, Medical University of Lublin, Lublin, Poland. kinga_bur@yahoo.com
Luchowski
Piotr
P
Wojczal
Joanna
J
Ksiazek
Andrzej
A
Stelmasiak
Zbigniew
Z
D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000235:genetics; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
D018932:Chemokine CCL2