title: The utility of cardiopulmonary exercise testing to detect and track early-stage ischemic heart disease.
abstract: Evidence demonstrating the potential value of noninvasive cardiopulmonary exercise testing (CPET) to accurately detect exercise-induced myocardial ischemia is emerging. This case-based concept report describes CPET abnormalities in an asymptomatic at-risk man with suspected early-stage ischemic heart disease. When CPET was repeated 1 year after baseline assessment, his cardiovascular function had worsened, and an anti-atherosclerotic regimen was initiated. When the patient was retested after 3.3 years, the diminished left ventricular function had reversed with pharmacotherapy directed at decreasing cardiovascular events in patients with coronary artery disease. Thus, in addition to identifying appropriate patients in need of escalating therapy for atherosclerosis, CPET was useful in monitoring progression and reversal of abnormalities of the coronary circulation in a safe and cost-effective manner without the use of radiation. Serial CPET parameters may be useful to track changes marking the progression and/or regression of the underlying global ischemic burden.
authors.affiliation: Research and Development Department, MET-TEST, Atlanta, GA, USA. schaudhry@mettest.net
authors.forename: Sundeep
authors.initials: S
authors.lastname: Chaudhry
authors.forename: Ross A
authors.initials: RA
authors.lastname: Arena
authors.forename: James E
authors.initials: JE
authors.lastname: Hansen
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Lewis
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Myers
authors.forename: Laurence S
authors.initials: LS
authors.lastname: Sperling
authors.forename: Brian D
authors.initials: BD
authors.lastname: Labudde
authors.forename: Karlman
authors.initials: K
authors.lastname: Wasserman
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology*; D008078:Cholesterol, LDL / Q000097:blood; D018450:Disease Progression; D005080:Exercise Test / Q000379:methods / Q000706:statistics & numerical data*; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D015203:Reproducibility of Results
chemical_list: D008078:Cholesterol, LDL