Interactions between giant unilamellar vesicles and charged core-shell magnetic nanoparticles.
This work combined two tools, giant unilamellar vesicles (GUVs) and core-shell magnetic nanoparticles (CSMNs), to develop a simplified model for studying interactions between the cell membrane and nanoparticles. We focused on charged functionalized CSMNs that can be either cationic or anionic. Using optical, electron, and confocal microscopy, we found that giant vesicle-nanoparticle interactions did not result from a simple electrostatic phenomenon because cationic CSMNs tended to bind to positively charged bilayers, whereas anionic CSMNs remained inert.
Laurencin
Mathieu
M
UPMC University of Paris 06-CNRS-ESPCI Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France.
Georgelin
Thomas
T
Malezieux
Bernard
B
Siaugue
Jean-Michel
JM
Ménager
Christine
C
D002462:Cell Membrane / Q000737:chemistry; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D055620:Optical Phenomena; D053835:Unilamellar Liposomes / Q000737:chemistry*
D053835:Unilamellar Liposomes