[Cytokines in bone diseases. Wnt signal and excessive bone formation].
Wnt signal has been known to play various roles in many organ from the beginning of embryogensis. Its role in bone metabolism has also been investigated and established. Lipoprotein receptor-related protein 5 (LRP5) is one of the important molecules in wnt signal pathway whose point mutations are related to both bone loss and excessive bone formation. Wnt signal is involved in the action of sclerostin which was found as a gene for osteosclerosis, one of the diseases of excessive bone formation. Wnt signal is keeping the position as an important research target for normal and pathological bone formation.
Hosoi
Takayuki
T
Department of Clinical Research and Development, National Center for Geriatrics and Gerontology.
D048868:Adaptor Proteins, Signal Transducing; D015519:Bone Density / Q000235:genetics; D001851:Bone Diseases, Metabolic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism; D002114:Calcinosis / Q000235:genetics*; D005819:Genetic Markers / Q000502:physiology; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics* / Q000502:physiology*; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D017354:Point Mutation; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; C422903:SOST protein, human; D051153:Wnt Proteins