title: Reversible IgA deficiency after severe Gram-negative bacteria infection in a patient with systemic sclerosis.
abstract: A 43-year-old woman with systemic sclerosis (SSc) developed IgA deficiency (IgAD) after cholecystitis. The severe decrease of IgA (<10 mg/dl) partially recovered after 5 years. She had repeated episodes of infection during IgAD. Anti-IgA antibody was not detected. Flow cytometric analysis showed that peripheral CD19(+)IgA(+) and CD38(+)IgA(+) cells were normally present. Although the mechanism of secondary IgAD is still vague, its association with autoimmune diseases including SSc and also with bacterial infection is discussed.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgi-machi, Kita-ku, Osaka, 530-8480, Japan. mayagita@kitano-hp.or.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Yagita
authors.forename: Kazuta
authors.initials: K
authors.lastname: Yasui
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hori
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000328:Adult; D002764:Cholecystitis / Q000150:complications*; D005260:Female; D005434:Flow Cytometry; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D017098:IgA Deficiency / Q000276:immunology* / Q000473:pathology; D007070:Immunoglobulin A / Q000097:blood; D020127:Recovery of Function; D012595:Scleroderma, Systemic / Q000097:blood / Q000276:immunology* / Q000473:pathology
chemical_list: D007070:Immunoglobulin A