[Cytokines in bone diseases. Cytokine and postmenopausal osteoporosis].
Bone resorption is regulated by various cytokines. In postmenopausal osteoporosis, bone loss due to estrogen deficiency is closely related to the production of bone-resorbing cytokine. Especially, the increased production of IL-1, IL-6 and TNF-α could induce the expression of RANKL in bone tissues to enhance osteoclastogenesis. Relationship between estrogen deficiency and various cytokines is important to clarify the pathogenesis of postmenopausal osteoporosis.
Inada
Masaki
M
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Miyaura
Chisato
C
D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D004195:Disease Models, Animal; D004967:Estrogens / Q000172:deficiency / Q000502:physiology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D051379:Mice; D010010:Osteoclasts / Q000166:cytology; D015663:Osteoporosis, Postmenopausal / Q000209:etiology*; D053245:RANK Ligand / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D004967:Estrogens; D007375:Interleukin-1; D015850:Interleukin-6; D053245:RANK Ligand; D014409:Tumor Necrosis Factor-alpha