Salvianolic acid A exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice.
Benzodiazepine was known to produce amnesia. Salvianolic acid A extracted from Salvia miltiorrhiza was an effective antioxidant. The objective of the study was to evaluate the effect of salvianolic acid A on diazepam-induced amnesia in mice. C57BL/6 mice were treated with salvianolic acid A at doses of 10, 20 and 40 mg/kg following administration with diazepam at a dose of 3 mg/kg. Morris water maze was performed to evaluate the effect of salvianolic acid A on amnesia. The antioxidative parameters in hippocampus were measured. The results showed that salvianolic acid A decreased the mean escape latency and increased the percentage of time spent in target quadrant. Salvianolic acid A reduced the content of malondialdehyde and increased the activities of superoxide dismutase, catalase and glutathione peroxidase in hippocampus. The findings demonstrated that salvianolic acid A had antiamnesic effects on diazepam-induced anterograde amnesia in mice, by augmenting the antioxidative capacity of hippocampus.
Wang
T
T
Department of Pharmacology, School of Pharmacy, Yantai University, Yantai 264005, People's Republic of China.
Shan
S Y
SY
Han
B
B
Zhang
L M
LM
Fu
F H
FH
D020324:Amnesia, Anterograde / Q000139:chemically induced* / Q000188:drug therapy*; D000818:Animals; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007773:Lactates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism
D002109:Caffeic Acids; D006993:Hypnotics and Sedatives; D007773:Lactates; D018697:Nootropic Agents; C066201:salvianolic acid A; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003975:Diazepam