title: Cytotoxic Hexacyclic Triterpene Acids from Euscaphis japonica.
abstract: Six hexacyclic triterpene acids (1-6), named euscaphic acids A-F, and eight known triterpene acid compounds (7-14) were isolated from an ethanolic extract of twigs of Euscaphis japonica. Compounds 8 and 10 were isolated for the first time from a natural source. Triterpenes 1-6 possess hexacyclic skeletons with a 13α,27-cyclopropane ring. Structural elucidation of compounds 1-6 was established by spectroscopic methods, especially 2D NMR techniques ((1)H-(1)H COSY, HMQC, HMBC, and NOESY). Compounds 3, 4, and 14 showed significant cytotoxicity against different cancer cell lines [IC50 = 2.54 (NCI-H460), 3.61 (MCF-7), and 3.27 μM (CEM) for 3, 4, and 14, respectively].
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China.
authors.forename: Jing-Jy
authors.initials: JJ
authors.lastname: Cheng
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Cheng
authors.forename: Chun-Tang
authors.initials: CT
authors.lastname: Chiou
authors.forename: I-Jung
authors.initials: IJ
authors.lastname: Lee
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013624:Taiwan; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C007695:euscaphic acid