Protease sensing with nanoparticle based platforms.
Nanoparticulate systems in various unique configurations are highly effective at detecting protease activity both in vivo and in vitro. In this article, we have summarised the conventional modern methods for monitoring protease activity, and critically appraised recent advances in protease-responsive nanosensors.
Welser
Katharina
K
School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK NG7 2RD.
Adsley
Rosemary
R
Moore
Bernadette M
BM
Chan
Weng C
WC
Aylott
Jonathan W
JW
D015374:Biosensing Techniques / Q000379:methods*; D010450:Endopeptidases / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D049452:Green Fluorescent Proteins / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D045663:Quantum Dots; D013059:Spectrum Analysis, Raman
D005456:Fluorescent Dyes; D011108:Polymers; D049452:Green Fluorescent Proteins; D010450:Endopeptidases