title: Labelling of commercially available human serum albumin kits with 68Ga as surrogates for 99mTc-MAA microspheres.
abstract: An alternative method of labelling different commercially available human serum albumin kits with generator produced (68)Ga as possible surrogate markers for the investigation of the biodistribution, and to exclude a possible lung shunt in patients with solid primary tumours and liver metastases by positron emission-tomography (PET) and effective substitute for (99m)Tc HSA as a PET perfusion tracer is described. The radioactive labelling with (68)Ga was based on the elution of a commercial (68)Ge/(68)Ga generator system, which uses a modified tin dioxide column to absorb (68)Ga. We obtained (68)Ga-MAA and (68)Ga-HSA in radiochemical yields of 79 ± 5% with less than 5% free (68)Ga. The whole procedure takes a total of less than 30 min from elution to the final product.
authors.affiliation: Clinic of Nuclear Medicine, University Medical Centre Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany. maus@unimedizin-mainz.de
authors.forename: Stephan
authors.initials: S
authors.lastname: Maus
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Buchholz
authors.forename: Stephan
authors.initials: S
authors.lastname: Ament
authors.forename: Christoph
authors.initials: C
authors.lastname: Brochhausen
authors.forename: Nicole
authors.initials: N
authors.lastname: Bausbacher
authors.forename: Mathias
authors.initials: M
authors.lastname: Schreckenberger
mesh_terms: D000818:Animals; D005710:Gallium Radioisotopes / Q000737:chemistry*; D006801:Humans; D008863:Microspheres; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D012709:Serum Albumin