Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola.
Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.
Wu
Quan-Xiang
QX
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Crews
Mitchell S
MS
Draskovic
Marija
M
Sohn
Johann
J
Johnson
Tyler A
TA
Tenney
Karen
K
Valeriote
Frederick A
FA
Yao
Xiao-Jun
XJ
Bjeldanes
Leonard F
LF
Crews
Phillip
P
D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004151:Dipeptides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure
D004151:Dipeptides; C555149:azonazine