Unraveling the genetic basis of asthma and allergic diseases.
Asthma and allergic diseases are believed to be complex genetic diseases which may result from the interaction of multiple genetic factors and environmental stimuli. In past decades, great efforts have been exerted in unraveling their genetic basis. The strategies in discovering genes and genetic variants, confirming their importance in pathogenesis of asthma and allergic diseases, as well as their strengths and limitations are summarized comprehensively and concisely. The current consensus about the genetic basis of asthma and allergic diseases is briefly described as well.
Meng
Jian-Feng
JF
Department of Pediatric Immunology Research, Allergy Clinic Section, Children's Mercy Hospital & Clinics/School of Medicine, University of Missouri at Kansas City, Kansas City, USA.
Rosenwasser
Lanny J
LJ