[Osteoprotegerin and bone mineral density in patients with chronic obstructive pulmonary disease].
OBJECTIVE
to study a relationship between the serum level of osteoprotegerin (OPG), the markers of bone metabolism, tumor necrosis factor-alpha (TNF-alpha), and bone mineral density (BMD) in patients with chronic obstructive pulmonary disease (COPD).


METHODS
Fifty-five patients aged 44 to 58 years who had COPD were examined. BMD in the lumbar spine (L(II)-L(IV)) and left femoral neck (FN) was estimated by dual-energy X-ray absorptiometry (DXA) on Lunar Prodigy Densitometer (USA). The serum levels of OPG, BCrossLaps (BCL), and TNF-alpha were measured. A control group comprised 25 healthy non-smoking gender- and age-matched volunteers.


RESULTS
Osteopenic syndrome (T-test < -1SD) was recorded in 43 (78%) of the 55 examined patients with COPD. In 29 (52%) of them, T-test was lower in two zones towards osteoporosis in 14 (25%) towards osteopenia. In patients with COPD, TNF-alpha concentrations were significantly higher than that in the control group. At the same time, TNF-alpha levels correlated positively with the bone resorption marker BCL (r = 0.52; p = 0.042) and negatively with OPG (r = 0.56; p = 0.003). A direct correlation was established between serum OPG concentrations and BMD in both L(II)-L(IV) and FN (r = 0.56; p < 0.01 and r = 0.47; p < 0.05, respectively)


CONCLUSIONS
The patients with COPD were found to have lower BMD, elevated TNF-alpha concentrations, an increased bone resorption marker, and lower serum OPG levels. The associations between the levels of OPG, TNF-alpha, and BMD suggest that these markers are implicated in the pathogenesis of osteopenic syndrome in COPD.
Kochetkova
E A
EA
Nevzorova
V A
VA
Maĭstrovskaia
Iu V
IuV
Massard
G
G
D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D005272:Femur Neck / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D053244:Osteoprotegerin / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D013131:Spine / Q000000981:diagnostic imaging; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D053244:Osteoprotegerin; D014409:Tumor Necrosis Factor-alpha