title: Extraction of the plane of minimal cross-sectional area of the corpus callosum using template-driven segmentation.
abstract: Changes in corpus callosum (CC) size are typically quantified in clinical studies by measuring the CC cross-sectional area on a midsagittal plane. We propose an alternative measurement plane based on the role of the CC as a bottleneck structure in determining the rate of interhemispheric neural transmission. We designate this plane as the Minimum Corpus Callosum Area Plane (MCCAP), which captures the cross section of the CC that best represents an upper bound on interhemispheric transmission. Our MCCAP extraction method uses a nested optimization framework, segmenting the CC as it appears on each candidate plane, using registration-based segmentation. We demonstrate the robust convergence and high accuracy of our method for magnetic resonance images and present preliminary clinical results showing higher sensitivity to disease-induced atrophy.
authors.affiliation: Medical Image Analysis Lab, Simon Fraser University, Canada.
authors.forename: Neda
authors.initials: N
authors.lastname: Changizi
authors.forename: Ghassan
authors.initials: G
authors.lastname: Hamarneh
authors.forename: Omer
authors.initials: O
authors.lastname: Ishaq
authors.forename: Aaron
authors.initials: A
authors.lastname: Ward
authors.forename: Roger
authors.initials: R
authors.lastname: Tam
mesh_terms: D000465:Algorithms; D019412:Anatomy, Cross-Sectional / Q000379:methods*; D003337:Corpus Callosum / Q000473:pathology*; D005103:Expert Systems; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique