title: Personalization of cubic Hermite meshes for efficient biomechanical simulations.
abstract: Cubic Hermite meshes provide an efficient representation of anatomy, and are useful for simulating soft tissue mechanics. However, their personalization can be a complex, time consuming and labour-intensive process. This paper presents a method based on image registration and using an existing template for deriving a patient-specific cubic Hermite mesh. Its key contribution is a solution to customise a Hermite continuous description of a shape with the use of a discrete warping field. Fitting accuracy is first tested and quantified against an analytical ground truth solution. To then demonstrate its clinical utility, a generic cubic Hermite heart ventricular model is personalized to the anatomy of a patient, and its mechanical stability is successfully tested. The method achieves an easy, fast and accurate personalization of cubic Hermite meshes, constituting a crucial step for the clinical adoption of physiological simulations.
authors.affiliation: Computing Laboratory, University of Oxford, UK. pablo.lamata@comlab.ox.ac.uk
authors.forename: Pablo
authors.initials: P
authors.lastname: Lamata
authors.forename: Steven
authors.initials: S
authors.lastname: Niederer
authors.forename: David
authors.initials: D
authors.lastname: Barber
authors.forename: David
authors.initials: D
authors.lastname: Norsletten
authors.forename: Jack
authors.initials: J
authors.lastname: Lee
authors.forename: Rod
authors.initials: R
authors.lastname: Hose
authors.forename: Nic
authors.initials: N
authors.lastname: Smith
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D020342:Finite Element Analysis; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008953:Models, Anatomic; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity