title: Search for antifungal compounds from the wood of durable tropical trees.
abstract: Research on antifungal compounds from the durable wood from French Guiana Amazonian forest trees highlights the correlation between the activity of their extracts against wood-rotting fungi and human pathogens. The fractionation of an ethyl acetate extract of Sextonia rubra wood led to the isolation of rubrenolide (1) and rubrynolide (2). The potential of compounds 1 and 2 is described through the evaluation of their activity against 16 pathogenic fungi and their cytotoxicity toward NIH-3T3 mammalian fibroblast cells.
authors.affiliation: CNRS, UMR ECOFOG, Université des Antilles et de la Guyane, 97300 Cayenne, France.
authors.forename: Alice M S
authors.initials: AM
authors.lastname: Rodrigues
authors.forename: Phellipe N E T
authors.initials: PN
authors.lastname: Theodoro
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Charlie
authors.initials: C
authors.lastname: Basset
authors.forename: Maria R R
authors.initials: MR
authors.lastname: Silva
authors.forename: Jacques
authors.initials: J
authors.lastname: Beauchêne
authors.forename: Laila S
authors.initials: LS
authors.lastname: Espíndola
authors.forename: Didier
authors.initials: D
authors.lastname: Stien
mesh_terms: D000080:Acetals / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D005616:French Guiana; D019770:Lauraceae / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D018547:Plant Stems / Q000737:chemistry; D011124:Polyporaceae / Q000737:chemistry*; D014197:Trees / Q000382:microbiology*; D014934:Wood / Q000382:microbiology
chemical_list: D000080:Acetals; D000475:Alkenes; D000480:Alkynes; D000935:Antifungal Agents; C511467:rubrenolide; C000605893:rubrynolide