title: Single-dose time-resolved contrast enhanced hybrid MR angiography in diagnosis of peripheral arterial disease: compared with digital subtraction angiography.
abstract: OBJECTIVE
  To prospectively study the diagnostic performance of hybrid single-dose contrast-enhanced MRA of peripheral arterial disease (PAD), with digital subtraction angiography (DSA) as the reference standard.
  
  
  METHODS
  Hybrid MRA, combining time resolved imaging of contrast kinetics and two-station bolus-chase sequences, of lower limb was performed in 31 PAD patients (21 men, 10 women; mean age, 72 years) with two separate gadobenate dimeglumine (8 mL) injections in each sequence. Two independent blinded readers analyzed the vascular stenosis (32 segments in each limb). Sensitivity, specificity, and accuracy in all vascular segments and segments below popliteal artery were calculated. Interobserver agreements on MRA and intermodality agreements between MRA and DSA were calculated by using k statistics.
  
  
  RESULTS
  Sensitivity, specificity, and accuracy of the hybrid MRA with regard to hemodynamically significant stenosis in all vascular segments were 92%, 97%, and 95% for reader 1, and 90%, 92%, and 92%, for reader 2, respectively. The interobsever agreements on MRA were good (k = 0.77-0.74) for all-grade stenosis, and excellent (k = 0.82-0.81) for hemadynamically significant stenosis. The intermodality agreements are good to excellent (k = 0.73-0.94).
  
  
  CONCLUSIONS
  Single-dose hybrid MRA is a safe and reliable noninvasive alternative to conventional DSA in the assessment of PAD patients.
authors.affiliation: Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Chun-Chieh
authors.initials: CC
authors.lastname: Wang
authors.forename: Huei-Lung
authors.initials: HL
authors.lastname: Liang
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Hsiao
authors.forename: Matt Chiung-Yu
authors.initials: MC
authors.lastname: Chen
authors.forename: To-Ho
authors.initials: TH
authors.lastname: Wu
authors.forename: Chieh-Jen
authors.initials: CJ
authors.lastname: Wu
authors.forename: Jer-Shyung
authors.initials: JS
authors.lastname: Huang
authors.forename: Yih-Huei
authors.initials: YH
authors.lastname: Lin
authors.forename: Huay-Ben
authors.initials: HB
authors.lastname: Pan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction / Q000379:methods*; D003251:Constriction, Pathologic / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D007700:Kinetics; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D058729:Peripheral Arterial Disease / Q000175:diagnosis* / Q000473:pathology*; D012015:Reference Standards; D015203:Reproducibility of Results