5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.
Metabolic acidosis after acute acetaminophen overdose is typically attributed to either transient lactic acidosis without evidence of hepatic injury or hepatic failure. High levels of the organic acid 5-oxoprolinuria are usually reported in patients with predisposing conditions, such as sepsis, who are treated in a subacute or chronic fashion with acetaminophen. The authors report a case of a 40-year-old woman who developed anion gap metabolic acidosis and somnolence after an acute acetaminophen overdose. Substantial hepatic damage did not occur, which ruled out acetaminophen-induced hepatic insufficiency as a cause of the patient's acidosis or altered mental status. Urinalysis revealed elevated levels of 5-oxoproline, suggesting that the patient's acute acetaminophen overdose was associated with marked anion gap metabolic acidosis due solely to 5-oxoproline without hepatic complications. The acidosis fully resolved with N-acetylcysteine treatment and supportive care including hydration.
Lawrence
David T
DT
Division of Medical Toxicology, University of Virginia School of Medicine, P.O. Box 800774, Charlottesville, VA 22908-0774, USA.
Bechtel
Laura K
LK
Charlton
Nathan P
NP
Holstege
Christopher P
CP
D000082:Acetaminophen / Q000009:adverse effects*; D000111:Acetylcysteine / Q000627:therapeutic use; D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000139:chemically induced* / Q000188:drug therapy / Q000628:therapy; D000208:Acute Disease; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D011761:Pyrrolidonecarboxylic Acid / Q000378:metabolism*
D018712:Analgesics, Non-Narcotic; D016166:Free Radical Scavengers; D000082:Acetaminophen; D011761:Pyrrolidonecarboxylic Acid; D000111:Acetylcysteine