title: Implication of pancreatic image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis.
abstract: OBJECTIVE
  To clarify the implication of pancreatic findings on transabdominal ultrasound and/or abdominal computed tomographic scan on outcomes of islet isolation and endocrine function after total pancreatectomy (TP) with islet autotransplantation (IAT).
  
  
  METHODS
  Retrospective review of islet isolations and graft functions in a cohort of patients with chronic pancreatitis who received TP with IAT from December 2007 to September 2009. Patients were categorized into the following 2 groups on the basis of their transabdominal ultrasound or computed tomographic findings before IAT: early group (normal or equivocal of Cambridge classification) and advanced group (mild to marked).
  
  
  RESULTS
  A total of 12 patients (early group, n=6; advanced group, n=6) were included. Total islet yield per pancreas weight and per patient body weight in the early group was significantly higher compared with that in the advanced group (6989±659 vs 3567±615 islet equivalents per gram, P<0.01; 8556±953 vs 3847±739 islet equivalents per kilogram, P<0.01, respectively). Four patients (67%) in the early group became insulin-free, whereas 2 patients (33%) in the advanced group obtained insulin independence. However, both groups maintained islet graft function and similar glycated hemoglobin levels after transplantation.
  
  
  CONCLUSIONS
  Excellent glycemic control was observed in both groups of patients who received TP with IAT, although the early group showed a significantly better outcome of islet isolation.
authors.affiliation: Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA.
authors.forename: Morihito
authors.initials: M
authors.lastname: Takita
authors.forename: Bashoo
authors.initials: B
authors.lastname: Naziruddin
authors.forename: Shinichi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Noguchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimoda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Chujo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itoh
authors.forename: Koji
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Nicholas
authors.initials: N
authors.lastname: Onaca
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lamont
authors.forename: Luis F
authors.initials: LF
authors.lastname: Lara
authors.forename: Marlon F
authors.initials: MF
authors.lastname: Levy
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D050500:Pancreatitis, Chronic / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography