title: Interdigitating dendritic cell sarcoma of the tonsil.
abstract: Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from antigen-presenting cells, with 55 cases reported thus far. A standard treatment modality is still being debated. This report describes a 56-year-old female who presented with right tonsillar enlargement and right submandibular swelling for 6 months. Treatment with empiric antibiotics did not result in improvement of her symptoms. Fine needle aspiration of the tonsil revealed no malignant cells. Tonsillectomy was eventually performed due to persistent symptoms. Based on microscopic findings, immunohistochemical stains, and review of the literature, the present case was finally diagnosed as IDCS of the tonsil with cervical lymph node involvement. The patient received four cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, and a clinically complete response was achieved followed by adjuvant radiation.
authors.affiliation: Medical Oncology, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Jin-Hyoung
authors.initials: JH
authors.lastname: Kang
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Chun
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Chang
authors.forename: Yeon-Sil
authors.initials: YS
authors.lastname: Kim
authors.forename: Sang Nam
authors.initials: SN
authors.lastname: Lee
authors.forename: Min-Sik
authors.initials: MS
authors.lastname: Kim
authors.forename: Chang-Suk
authors.initials: CS
authors.lastname: Kang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D018714:Radiotherapy, Adjuvant; D014067:Tonsillar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D014068:Tonsillectomy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone