title: Brain metastases of mouse mammary adenocarcinoma is increased by acute stress.
abstract: Brain metastases from mammary adenocarcinoma constitute the chief cause of morbidity and mortality. Some evidence suggests that stress may contribute to disease progression and metastases. Here we show that acute restraint stress (30 min) induces statistically significant increase in brain metastases of systemically administered luciferase-tagged 4T1-BR-3P mouse mammary adenocarcinoma cells as evidenced by the total brain-associated photons from 5.6 × 10(7) photons in unstressed controls to 1.7 × 10(8) photons in C57BL/6 (p = 0.0018) and from 7.6 × 10(7) to 2.1 × 10(7) photons in BALB/c (p = 0.004) mice. Acute stress may increase metastases by disrupting the blood-brain-barrier (BBB), through release of corticotropin-releasing-hormone (CRH) activating perivascular brain mast cells.
authors.affiliation: Department of Neurology, Medical University of Lodz, Poland.
authors.forename: Jacek J
authors.initials: JJ
authors.lastname: Rozniecki
authors.forename: G Gary
authors.initials: GG
authors.lastname: Sahagian
authors.forename: Duraisamy
authors.initials: D
authors.lastname: Kempuraj
authors.forename: Kai
authors.initials: K
authors.lastname: Tao
authors.forename: Stanley
authors.initials: S
authors.lastname: Jocobson
authors.forename: Bodi
authors.initials: B
authors.lastname: Zhang
authors.forename: Theoharis C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001814:Blood-Testis Barrier / Q000503:physiopathology; D001921:Brain; D001932:Brain Neoplasms / Q000473:pathology* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D017785:Photons; D012149:Restraint, Physical / Q000009:adverse effects*
chemical_list: D003346:Corticotropin-Releasing Hormone