title: How reliable are scientific studies?
abstract: There is growing concern that a substantial proportion of scientific research may in fact be false. A number of factors have been proposed as contributing to the presence of a large number of false-positive results in the literature, one of which is publication bias. We discuss empirical evidence for these factors.
authors.forename: Marcus R
authors.initials: MR
authors.lastname: Munafò
authors.forename: Jonathan
authors.initials: J
authors.lastname: Flint
mesh_terms: D005189:False Positive Reactions; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D011336:Probability; D017594:Publication Bias; D015203:Reproducibility of Results; D012106:Research / Q000592:standards*