[Expression and significance of Fas/APO-1 and Bcl-2 protein in human lung cancer.].
BACKGROUND
To investigate the role of Fas/APO-1 and Bcl-2 in oncogenesis and progression of lung cancer.


METHODS
The expression of Fas/APO-1 and Bcl-2 protein were detected in 65 lung cancer tissues and 46 normal lung tissues by immunohistochemistry.


RESULTS
The positive rate of Fas/APO-1 protein expression in lung cancer tissues was 56. 92 % , which was significantly lower than that in normal lung tissues (82. 61 %) ( P < 0. 01) . The positive rate of Bcl-2 protein expression was 46. 15 %. It was significantly higher than that in normal lung tissues (6. 52 %) ( P < 0. 01) .


CONCLUSIONS
Both Fas/APO-1 and Bcl-2 may play an role in the oncogenesis and progression of lung cancer.
Yi
Y
Y
Department of Thoracocardiac Surgery , 175th Hospital of People's Liberation Army , Zhangzhou , Fujian 363000 , P. R. China.
Gan
X
X
Lin
C
C
Hu
X
X