title: Clinical and radiological features of imported chikungunya fever in Japan: a study of six cases at the National Center for Global Health and Medicine.
abstract: Chikungunya fever (CHIKF) is currently distributed in Africa and in South and Southeast Asia; outbreaks have occurred periodically in the region over the past 50 years. After a large outbreak had occurred in countries in the western Indian Ocean region in 2005, several countries reported cases of CHIKF from travelers who had visited affected areas. In Japan, there have been only 15 cases of CHIKF patients so far, according to the National Institute of Infectious Diseases. Therefore, to evaluate the clinical and radiological features associated with the disease, we describe 6 imported cases of CHIKF. All of the patients had had prolonged arthralgia on admission to our hospital, and diagnosis was confirmed with specific antibodies by using an IgM-capture enzyme-linked immunoassay and a plaque reduction neutralizing antibody assay. Magnetic resonance imaging (MRI) of one patient revealed erosive arthritis and tenosynovitis during the convalescence stage. Clinicians should be aware of the late consequences of infection by the chikungunya virus (CHIKV) and recognize the possible association of subacute and chronic arthritis features. In addition, competent vectors of CHIKV, Aedes aegypti, can now be found in many temperate areas of the eastern and western hemispheres, including Japan. This fact raises concern that the virus could be introduced and become established in these areas. This necessitates an increased awareness of the disease, because imported cases are likely to contribute to the spread of CHIKV infection wherever the competent mosquito vectors are distributed.
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan. mizunomd@hotmail.com
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kato
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeshita
authors.forename: Mugen
authors.initials: M
authors.lastname: Ujiie
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kanagawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
authors.forename: Chang-Kweng
authors.initials: CK
authors.lastname: Lim
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Takasaki
mesh_terms: D000328:Adult; D018354:Alphavirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D018771:Arthralgia / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007564:Japan; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D014195:Travel