Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005.
BACKGROUND
Craniopharyngiomas are rare epithelial tumors that are presumed to arise from the remnants of Rathke's pouch.


OBJECTIVE
This study was designed to evaluate the outcome characteristics of craniopharyngiomas treated in a single institution and to determine whether the adamantinomatous craniopharyngioma should be considered more aggressive than a World Health Organization (WHO) grade I neoplasm.


METHODS
We identified all patients with craniopharyngioma given their diagnoses at University of California, San Francisco in a 20-year period and performed a retrospective analysis of clinicopathological and outcome characteristics. Statistical analyses were performed to determine factors that affect survival characteristics.


RESULTS
Eighty patients were included in the study based on the selection criteria. Sixty-nine tumors were adamantinomatous, 9 were papillary, and 2 were unclassified. All pediatric tumors were adamantinomatous. Visual field examination in 60 patients revealed a defect in 39 and only 14 showed bitemporal field defects. Hormonal tests with abnormal results were more common in younger patients. During a median follow-up of 82 months, 38 tumors recurred. Four of 9 gross total resections and 34 of 59 subtotal resections recurred. Median time to recurrence was 16.3 months for gross total and 11.7 for subtotal resections. Progression-free survival did not differ between males and females or children and adults. There was a negative correlation between age and overall survival.


CONCLUSIONS
Adamantinomatous craniopharyngioma is a locally aggressive neoplasm with a significant rate of recurrence. This is not in keeping with the current designation of a WHO grade I neoplasm. Subtotal resection is associated with less mortality/morbidity but a higher recurrence rate. Given the high numbers of "silent" defects, formal visual field testing should be performed in all patients with craniopharyngiomas.
Pekmezci
Melike
M
Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
Louie
Jonathan
J
Gupta
Nalin
N
Bloomer
Michele M
MM
Tihan
Tarik
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D002140:California / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000517:prevention & control; D010911:Pituitary Neoplasms / Q000401:mortality* / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality*; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult