Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy.
Hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and the short treatment time window comprise major challenges for thrombolytic therapy. Improving tissue plasminogen activator therapy has become one of the highest priorities in the stroke field. Recent efforts have been aimed at identifying new strategies that might enhance the thrombolytic efficacy of tissue plasminogen activator at the same time as reducing its associated complications related to hemorrhage and neurotoxicity. We believe that the combination of low-dose tissue plasminogen activator with recombinant annexin A2 (a tissue plasminogen activator and plasminogen coreceptor) might constitute a promising approach. Our pilot study using a focal embolic stroke model in rats supports this hypothesis.
Fan
Xiang
X
Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Yu
Zhanyang
Z
Liu
Jianxiang
J
Liu
Ning
N
Hajjar
Katherine A
KA
Furie
Karen L
KL
Lo
Eng H
EH
Wang
Xiaoying
X
D000818:Animals; D017306:Annexin A2 / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D010865:Pilot Projects; D051381:Rats; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
D017306:Annexin A2; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator