title: Comparison of plasma clearance of iohexol and urinary clearance of inulin for measurement of GFR in children.
abstract: BACKGROUND
  Very few studies have been published that compare plasma clearance of iohexol (Cio) with renal clearance of inulin (Cin).
  
  
  METHODS
  Diagnostic test study.
  
  
  METHODS
  60 children aged 11.6 ± 4.5 years with different kidney disorders were investigated.
  
  
  METHODS
  Plasma Cio calculated from the slope and a single point.
  
  
  METHODS
  Renal Cin with continuous infusion during water diuresis. Results were compared with the correlation coefficients, bias and precision, accuracy percentage, root mean square error, and intraclass correlation.
  
  
  METHODS
  Measured creatinine clearance and estimated glomerular filtration rate based on serum creatinine level and height.
  
  
  RESULTS
  Mean Cin was 70.7 ± 41.3 (SD) mL/min/1.73 m². Mean differences between Cio and Cin were 2.65 and 2.00 mL/min/1.73 m² for the slope and single-point methods, respectively. Precision was ±16 mL/min/1.73 m² and intraclass correlation was 0.92 in both methods. Proportions of Cio within 30% of Cin were 83.3% and 86.7% for the slope and single-point methods, respectively.
  
  
  CONCLUSIONS
  A limited number of patients; no adults were studied.
  
  
  CONCLUSIONS
  Plasma Cio shows good agreement with renal Cin.
authors.affiliation: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. ulla.berg@ki.se
authors.forename: Ulla B
authors.initials: UB
authors.lastname: Berg
authors.forename: Rune
authors.initials: R
authors.lastname: Bäck
authors.forename: Gianni
authors.initials: G
authors.lastname: Celsi
authors.forename: Stella Edström
authors.initials: SE
authors.lastname: Halling
authors.forename: Inger
authors.initials: I
authors.lastname: Homberg
authors.forename: Rafael T
authors.initials: RT
authors.lastname: Krmar
authors.forename: Kajsa Åsling
authors.initials: KÅ
authors.lastname: Monemi
authors.forename: Helena
authors.initials: H
authors.lastname: Oborn
authors.forename: Maria
authors.initials: M
authors.lastname: Herthelius
mesh_terms: D002648:Child; D003287:Contrast Media / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000493:pharmacokinetics* / Q000652:urine; D007472:Iohexol / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D007472:Iohexol; D007444:Inulin; D003404:Creatinine