title: Galanin regulation of LH release in male rats.
abstract: The present study examines the role of cerebroventricular administered (IIIrd ventricle) galanin on LHRH and LH release in adult and immature male rats. In both age groups, galanin stimulated LHRH synthesis and release from the hypothalamus, leading to a higher release of pituitary LH which in turn increased plasma LH levels. Galantide, a galanin receptor blocker, on the other hand, drastically reduced hypothalamic LHRH and plasma LH while increasing pituitary LH. In vitro incubation of anterior pituitary cells with galanin followed by LHRH resulted in increased release of pituitary LH but not by galanin alone. Galantide exhibited no such effect either alone or with LHRH. These results indicate that galanin is an important regulator for both hypothalamic LHRH and hypophysial LH and its role is independent of age in the case of male rats.
authors.affiliation: Department of Zoology, University of Delhi, Delhi 110007, India. manishaarora2001@yahoo.co.in
authors.forename: Manisha Arora
authors.initials: MA
authors.lastname: Pandit
authors.forename: R N
authors.initials: RN
authors.lastname: Saxena
mesh_terms: D000818:Animals; D019004:Galanin / Q000031:analogs & derivatives / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D044088:Receptors, Galanin / Q000037:antagonists & inhibitors / Q000378:metabolism; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D044088:Receptors, Galanin; C074975:galantide; D013373:Substance P; D007987:Gonadotropin-Releasing Hormone; D019004:Galanin; D007986:Luteinizing Hormone