MhyADH catalysed Michael addition of water and in situ oxidation.
The Michael addition of water is a major challenge. Here an enzymatic approach is described. Interestingly, the enzyme (MhyADH) does not only catalyse the Michael addition of water but also the in situ oxidation of the product.
Jin
Jianfeng
J
Gebouw voor Scheikunde, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands.
Oskam
Philip C
PC
Karmee
Sanjib K
SK
Straathof
Adrie J J
AJ
Hanefeld
Ulf
U
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D020562:Betaproteobacteria / Q000201:enzymology; D055162:Biocatalysis; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry* / Q000378:metabolism
D014867:Water; D000426:Alcohol Dehydrogenase