Computational energetic model of morphogenesis based on multi-agent Cellular Potts Model.
The Cellular Potts Model (CPM) is a cellular automaton (CA), developed by Glazier and Graner in 1992, to model the morphogenesis. In this model, the entities are the cells. It has already been improved in many ways; however, a key point in biological systems, not defined in CPM, is energetic exchange between entities. We integrate this energetic concept inside the CPM. We simulate a cell differentiation inside a growing cell tissue. The results are the emergence of dynamic patterns coming from the consumption and production of energy. A model described by CA is less scalable than one described by a multi-agent system (MAS). We have developed a MAS based on the CPM, where a cell agent is implemented from the cell of CPM together with several behaviours, in particular the consumption and production of energy from the consumption of molecules.
Tripodi
Sébastien
S
European University of Brittany - UEB UBO, EA 3883-LISyC (in virtuo) 20 av Le Gorgeu CS, 93837 29238, Brest Cedex, France. sebastien.tripodi@univ-brest.fr
Ballet
Pascal
P
Rodin
Vincent
V
D002468:Cell Physiological Phenomena; D049109:Cell Proliferation; D002477:Cells / Q000166:cytology; D019295:Computational Biology; D003198:Computer Simulation; D004734:Energy Metabolism; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*