title: Chronic effect of ferulic acid from Pseudosasa japonica leaves on enhancing exercise activity in mice.
abstract: Ferulic acid derived from Pseudosasa japonica leaves, which possessed antioxidative potentials with DPPH- (54%) and ABTs- (65%) radical scavenging activities, and lipid-peroxidation inhibitory activity (71%), was orally administered to mice for 12 days in order to investigate its effects on exercise endurance capacity and alterations of antioxidant defense systems. Exhaustive swimming time was increased in the ferulic acid-supplemented group compared with the control group on days 6 and 12 (1.7- and 1.8-fold, respectively). When the mice were exhaustively exercised for 2 consecutive days, a high decrease (53%) was shown in the control group, but no change was found in the ferulic acid-treated group. The administration of ferulic acid significantly protected the depletion of enzymatic- and non enzymatic-antioxidants due to exhaustive exercise. Also, lipid-peroxidation levels decreased in the ferulic acid-treated group compared with the non exercised- and control-groups. These results suggest that ferulic acid from Pseudosasa japonica leaves has a chronic effect on endurance exercise capacity, which is attributed to its ability to ameliorate oxidative stress by improving antioxidant potentials.
authors.affiliation: Department of Food and Nutrition, Chonnam National University, Gwangju 550-757, Korea.
authors.forename: Yanghee
authors.initials: Y
authors.lastname: You
authors.forename: Kyungmi
authors.initials: K
authors.lastname: Kim
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Kwang-Won
authors.initials: KW
authors.lastname: Lee
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Jiyeon
authors.initials: J
authors.lastname: Chun
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
authors.forename: Jeongjin
authors.initials: J
authors.lastname: Park
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D010807:Physical Endurance / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D006109:Poaceae / Q000737:chemistry*; D013550:Swimming
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D016166:Free Radical Scavengers; C004999:ferulic acid