title: Mechanisms of tubulointerstitial fibrosis.
abstract: The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even reverse fibrosis remains elusive. Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies. How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding.
authors.affiliation: Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. mzeisber@bidmc.harvard.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Zeisberg
authors.forename: Eric G
authors.initials: EG
authors.lastname: Neilson
mesh_terms: D018450:Disease Progression; D004848:Epithelium / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D005355:Fibrosis; D020022:Genetic Predisposition to Disease; D006801:Humans; D009395:Nephritis, Interstitial / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D051437:Renal Insufficiency / Q000473:pathology / Q000503:physiopathology