title: SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks.
abstract: SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies.
  
  
  BACKGROUND
  http://www.win.tue.nl/∼mwestenb/spotxplore/.
authors.affiliation: Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands. m.a.westenberg@tue.nl
authors.forename: Michel A
authors.initials: MA
authors.lastname: Westenberg
authors.forename: Jos B T M
authors.initials: JB
authors.lastname: Roerdink
authors.forename: Oscar P
authors.initials: OP
authors.lastname: Kuipers
authors.forename: Sacha A F T
authors.initials: SA
authors.lastname: van Hijum
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D053263:Gene Regulatory Networks / Q000235:genetics*; D012984:Software; D014584:User-Computer Interface