Lack of correlation between short-term dynamics of diabetic retinopathy lesions and the arterial blood pressure.
BACKGROUND
Diabetic retinopathy is characterized by morphological lesions in the ocular fundus related to impairment of the retinal blood flow. The morphological lesions display a dynamic pattern of new formation and resorption of lesions, with a turn-over within days to weeks that may reflect basic pathophysiological mechanisms underlying the disease. However, a possible relationship between short-term fluctuations in diabetic retinopathy and risk factors for the long-term prognosis of diabetic retinopathy, such as the arterial blood pressure, has not been investigated.


METHODS
Five patients with moderate non-proliferative diabetic retinopathy were examined by fundus photography and measurement of the blood pressure at 1- to 2-week intervals for up to 1 year. The numbers of microaneurysms/haemorrhages and hard exudates in the macular area were counted, and changes in these counts were related to changes in the arterial blood pressure.


RESULTS
The five patients discontinued the study after 1-12 months, which resulted in between 5 and 39 examinations per patient, and amounted to a total of 101 examinations. There was a significant covariation between microaneurysms/haemorrhages and hard exudates, whereas there was no significant covariation between the number of either type of lesion and the blood pressure.


CONCLUSIONS
The cause of dynamic changes in diabetic retinopathy lesions occurring over days to weeks may involve other factors than changes in the arterial blood pressure.
Bek
Toke
T
Department of Ophthalmology, Århus University Hospital, DK-8000, Århus C, Denmark. toke.bek@mail.tele.dk
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000145:classification / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology
D006442:Glycated Hemoglobin