A new antitumor arabinopyranoside from Laurencia majuscula induces G2/M cell cycle arrest.
A new arabinopyranoside was isolated from the alga Laurencia majuscula (Harvey) Lucas, collected from the Xisha Islands in the South China Sea. Its structure was elucidated as hexadecyl-1-O-α-L-arabinopyranoside by spectroscopic analysis. It was found that arabinopyranoside had significant antitumor activity in LOVO and Bel-7402 cell lines. Flow cytometric analysis showed that arabinopyranoside arrested the cell cycle in the G2/M phase. Western blotting demonstrated that the protein expression of CDK1 and cyclin A related to the G2/M phase decreased markedly with arabinopyranoside treatment, with slight changes in cyclin B1 expression. Taken together, the findings identify a potential new antitumor therapeutic arabinopyranoside isolated from red alga Laurencia majuscula.
Du
Bin
B
Department of Pathology, Medical School, Jinan University, Guangzhou 510632, China.
Zhong
Xueyun
X
Liao
Xiaojian
X
Xu
Wenjie
W
Zhou
Xulong
X
Xu
Shihai
S
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D006017:Glycolipids / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D006017:Glycolipids; D006027:Glycosides; C554677:hexadecyl-1-O-arabinopyranoside