cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases.
"clinical NEUroPROteomics of neurodegenerative diseases" (cNEUPRO) is a Specific Targeted Research Project (STREP) within the sixth framework program of the European Commission dedicated to the search for novel biomarker candidates for Alzheimer's disease and other neurodegenerative diseases. The ultimate goal of cNEUPRO is to identify one or more valid biomarker(s) in blood and CSF applicable to support the early and differential diagnosis of dementia disorders. The consortium covers all steps required for the discovery of novel biomarker candidates such as acquisition of high quality CSF and blood samples from relevant patient groups and controls, analysis of body fluids by various methods, and finally assay development and assay validation. Here we report the standardized procedures for diagnosis and preanalytical sample-handling within the project, as well as the status of the ongoing research activities and some first results.
Spitzer
Philipp
P
Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany.
Klafki
Hans Wolfgang
HW
Blennow
Kaj
K
Buée
Luc
L
Esselmann
Hermann
H
Herruka
Sanna-Kaisa
SK
Jimenez
Connie
C
Klivenyi
Peter
P
Lewczuk
Piotr
P
Maler
Juan Manuel
JM
Markus
Katrin
K
Meyer
Helmut E
HE
Morris
Chris
C
Müller
Thorsten
T
Otto
Markus
M
Parnetti
Lucilla
L
Soininen
Hilkka
H
Schraen
Susanna
S
Teunissen
Charlotte
C
Vecsei
Laszlo
L
Zetterberg
Henrik
H
Wiltfang
Jens
J