title: Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels.
abstract: OBJECTIVE
  Obstructive sleep apnea (OSA) is a sleep-disordered breathing leading to vascular endothelial cells dysfunction, cognitive impairment, and abnormal lipid metabolism. serum brain-derived neurotrophic factor (BDNF) protein, cortisol, and lipid levels in OSA were investigated.
  
  
  METHODS
  All middle-aged subjects including healthy individuals without signs and symptoms of apnea-hypopnea and ear nose throat (ENT) outpatients were randomly recruited and screened by overnight polysomnogram (PSG). Apnea-hypopnea index (AHI) was used as a criteria to determine subjects to enroll in this program. According to AHI, they were separated into control and OSA groups. A group of 39 OSA patients (AHI ≥ 10 events/h) and 24 control subjects (AHI < 5 events/h) were selected. Serum BDNF protein was analyzed by enzyme-linked immunosorbent assay (ELISA) from venous blood collection at 8:00 a.m. following PSG. Serum cortisol was assayed by enzyme-chemiluminescense immuno assay (ECLIA). Serum lipid profile levels were determined by enzymatic colorimetric and homogeneous method.
  
  
  RESULTS
  Characteristics of OSA patients and control groups including gender, age, AHI, body weight, height, and BMI showed significant differences. Serum BDNF protein, cortisol, triglyceride, and total cholesterol levels in OSA and control groups were not significantly different. High density lipoprotein-cholesterol (HDL-c) in OSA was significantly lower than that of control (p = 0.008) while low density lipoprotein-cholesterol (LDL-c) was significantly higher than that of control (p = 0.04).
  
  
  CONCLUSIONS
  OSA had no significant effect on serum BDNF, cortisol, triglyceride, or total cholesterol levels while LDL-c and HDL-c levels in OSA patients compared to control were significantly different at p = 0.04, and p = 0.008, respectively.
authors.affiliation: Department of Physiology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand. panaree@swu.ac.th
authors.forename: Busarakumtragul
authors.initials: B
authors.lastname: Panaree
authors.forename: Mekseepralard
authors.initials: M
authors.lastname: Chantana
authors.forename: Sukhumsirichart
authors.initials: S
authors.lastname: Wasana
authors.forename: Neruntarat
authors.initials: N
authors.lastname: Chairat
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis; D013785:Thailand
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008055:Lipids; D006854:Hydrocortisone