Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates.
The thiocarbamates 4-RC(6)H(4)NHC(S)NR(2)' (R=H, Cl; R'=Me, Et), 4-ClC(6)H(4)NHC(S)NR (NR=2-pyridylpiperazine) react with cis-[PtCl(2)(PTA)(2)] (PTA=1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt{SC(NR(2)')=NC(6)H(4)R}(PTA)(2)](+) (R=H, Cl; R'=Me, Et), cis-[Pt{SC(NR)=NC(6)H(4)Cl}(PTA)(2)](+) (NR=2-pyridylpiperazine), which were isolated as their PF(6) salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay.
Bippus
Patrick
P
Fachbereich C-Anorganische Chemie, Bergische Universität Wuppertal, Wuppertal, Germany.
Skocic
Matthias
M
Jakupec
Michael A
MA
Keppler
Bernhard K
BK
Mohr
Fabian
F
D000218:Adamantane / Q000031:analogs & derivatives / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002413:Cations, Divalent; D002614:Chelating Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009943:Organophosphorus Compounds / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010879:Piperazines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism; D013859:Thiocarbamates / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C501763:1,3,5-triaza-7-phosphaadamantane; D000970:Antineoplastic Agents; D002413:Cations, Divalent; D002614:Chelating Agents; D009943:Organophosphorus Compounds; D009944:Organoplatinum Compounds; D010879:Piperazines; D011725:Pyridines; D013859:Thiocarbamates; C458160:2-pyridylpiperazine; D000218:Adamantane