title: Screening of enzyme inhibitors from traditional Chinese medicine.
abstract: Traditional Chinese medicine (TCM) has been used for more than 4000 years. By comparison with large combinatorial chemistry libraries and natural products of the West for high-throughput screening (HTS) of new drugs discovery, an advantage of TCM is that the preparation has clear efficacies on the therapy of some diseases. Although the effective components are not clear, the clear efficacies of TCM have been identified for long time practice, Therefore, TCMs should be valuable lead compound libraries with a definite therapy efficacy from the viewpoint of HTS. Nevertheless, current HTS technologies are not easily adapted to investigate TCMs because they are designed for screening a relatively pure known chemical at a known concentration. In contrast, TCMs are mixtures of unknown compounds in unknown concentrations that may differ markedly between samples from different plants. This article reviews the current and future researches on the enzyme inhibitors screening from TCM.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Shen
authors.forename: Yuming
authors.initials: Y
authors.lastname: Hu
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors