Search for antifungal compounds from the wood of durable tropical trees.
Research on antifungal compounds from the durable wood from French Guiana Amazonian forest trees highlights the correlation between the activity of their extracts against wood-rotting fungi and human pathogens. The fractionation of an ethyl acetate extract of Sextonia rubra wood led to the isolation of rubrenolide (1) and rubrynolide (2). The potential of compounds 1 and 2 is described through the evaluation of their activity against 16 pathogenic fungi and their cytotoxicity toward NIH-3T3 mammalian fibroblast cells.
Rodrigues
Alice M S
AM
CNRS, UMR ECOFOG, Université des Antilles et de la Guyane, 97300 Cayenne, France.
Theodoro
Phellipe N E T
PN
Eparvier
Véronique
V
Basset
Charlie
C
Silva
Maria R R
MR
Beauchêne
Jacques
J
Espíndola
Laila S
LS
Stien
Didier
D
D000080:Acetals / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D005616:French Guiana; D019770:Lauraceae / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D018547:Plant Stems / Q000737:chemistry; D011124:Polyporaceae / Q000737:chemistry*; D014197:Trees / Q000382:microbiology*; D014934:Wood / Q000382:microbiology
D000080:Acetals; D000475:Alkenes; D000480:Alkynes; D000935:Antifungal Agents; C511467:rubrenolide; C000605893:rubrynolide