Non-cholinergic pharmacotherapy approaches to Alzheimer's disease: the use of non-steroidal anti-inflammatory drugs.
The treatment of Alzheimer's disease is undoubtedly one of the greatest challenges of modern medicine and pharmacology. Affecting millions of people, Alzheimer's disease has become a major social problem. Several theories have been proposed to account for its pathogenesis. Possibly, the "amyloid cascade hypothesis" is the dominant one. However, the "inflammation hypothesis" also contributes to the pathogenesis of the disease. Thus, this study intends to describe the role of neuroinflammation in Alzheimer's disease, regarding its cellular and molecular components, and to examine if the use of non-steroidal anti-inflammatory drugs could be an effective "weapon" in the battle against it.
Tsartsalis
S
S
A" Laboratory of Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece.
Panagopoulos
P K
PK
Mironidou-Tzouveleki
M
M
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology*; D000682:Amyloid / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D018678:Cholinergic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy*; D058990:Molecular Targeted Therapy
D000682:Amyloid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018678:Cholinergic Agents