Effect of Naoling decoction on iNOS expression in hippocampal CA3 region in rats with synthetic Alzheimer's disease.
OBJECTIVE
To observe the effect of Naoling decoction on the expression of iNOS in hippocamal CA3 region in rats with Alzheimer's disease (AD), and to explore the potential mechanism.


METHODS
Forty SD rats were classified into 5 groups: a normal group, a sham-operated group, an AD group, a Naoling decoction group, and a Naofukang group. The Alzheimer's disease model was established by injecting Aβ1-42 into the hippocamal in the rats. Expression of iNOS in the CA3 region was measured with immunohistochemical staining.


RESULTS
Compared with the normal group, the expression of iNOS protein in the hippocampal CA3 fields in the AD group increased (P<0.05). Naoling decoction decreased the iNOS expression.


CONCLUSIONS
Naoling decoction can significantly reduce the expression of iNOS in the AD model rats, suggesting that Naoling decoction can be used for AD rats.
Zhong
Bingwu
B
Department of Traditional Chinese Medicine, Second Xiangya Hospital, Central South University, Changsha, China. zbw3201@126.com
Wang
Zhe
Z
He
Mingda
M
D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology*; D016229:Amyloid beta-Peptides; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism*; D010446:Peptide Fragments; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat