title: Substrate-induced covalent assembly of a chemzyme and crystallographic characterization of a chemzyme-substrate complex.
abstract: A substrate induced covalent assembly of a highly organized chemzyme known to be effective in both catalytic asymmetric aziridination and aza Diels-Alder reactions is described and the information gained from which led to an efficient one-pot aziridination protocol. The crystal structures of two chemzyme-iminium complexes were elucidated by X-ray diffraction analysis that provides critical insights into the binding of the substrates with the chemzyme.
authors.affiliation: Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.forename: Anil K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Rui H
authors.initials: RH
authors.lastname: Huang
authors.forename: Munmun
authors.initials: M
authors.lastname: Mukherjee
authors.forename: William D
authors.initials: WD
authors.lastname: Wulff
mesh_terms: D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013379:Substrate Specificity
chemical_list: D004798:Enzymes