title: Gd-complexes of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs).
abstract: We report the synthesis of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H(2)O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R(1) relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.
authors.affiliation: Department of Medical & Biological Engineering, Kyungpook National University, Daegu, 702-701, Korea.
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Ji-Ae
authors.initials: JA
authors.lastname: Park
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Sk Md
authors.initials: SM
authors.lastname: Nasiruzzaman
authors.forename: Duk-Sik
authors.initials: DS
authors.lastname: Kang
authors.forename: Jongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.forename: Tae-Jeong
authors.initials: TJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005296:Ferrous Compounds / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D000075163:Metallocenes; D004369:Pentetic Acid / Q000737:chemistry*; D051381:Rats; D012709:Serum Albumin / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D005296:Ferrous Compounds; D047028:Macrocyclic Compounds; D000075163:Metallocenes; D012709:Serum Albumin; D004369:Pentetic Acid; D005682:Gadolinium; C004998:ferrocene