title: New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities.
abstract: New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy. The new pyridazinone derivatives have been studied as vasorelaxant and antiplatelet agents. Analysis of biological data revealed the silyl ethers (4a-i) and N,O-dibenzyl derivatives (6g-i) as the most active compounds.
authors.affiliation: Departamento de Química Orgánica, Universidade de Vigo, 36310 Vigo, Spain.
authors.forename: Tamara
authors.initials: T
authors.lastname: Costas
authors.forename: Pedro
authors.initials: P
authors.lastname: Besada
authors.forename: Alessandro
authors.initials: A
authors.lastname: Piras
authors.forename: Laura
authors.initials: L
authors.lastname: Acevedo
authors.forename: Matilde
authors.initials: M
authors.lastname: Yañez
authors.forename: Francisco
authors.initials: F
authors.lastname: Orallo
authors.forename: Reyes
authors.initials: R
authors.lastname: Laguna
authors.forename: Carmen
authors.initials: C
authors.lastname: Terán
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines; D014665:Vasodilator Agents