Implication of pancreatic image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis.
OBJECTIVE
To clarify the implication of pancreatic findings on transabdominal ultrasound and/or abdominal computed tomographic scan on outcomes of islet isolation and endocrine function after total pancreatectomy (TP) with islet autotransplantation (IAT).


METHODS
Retrospective review of islet isolations and graft functions in a cohort of patients with chronic pancreatitis who received TP with IAT from December 2007 to September 2009. Patients were categorized into the following 2 groups on the basis of their transabdominal ultrasound or computed tomographic findings before IAT: early group (normal or equivocal of Cambridge classification) and advanced group (mild to marked).


RESULTS
A total of 12 patients (early group, n=6; advanced group, n=6) were included. Total islet yield per pancreas weight and per patient body weight in the early group was significantly higher compared with that in the advanced group (6989±659 vs 3567±615 islet equivalents per gram, P<0.01; 8556±953 vs 3847±739 islet equivalents per kilogram, P<0.01, respectively). Four patients (67%) in the early group became insulin-free, whereas 2 patients (33%) in the advanced group obtained insulin independence. However, both groups maintained islet graft function and similar glycated hemoglobin levels after transplantation.


CONCLUSIONS
Excellent glycemic control was observed in both groups of patients who received TP with IAT, although the early group showed a significantly better outcome of islet isolation.
Takita
Morihito
M
Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA.
Naziruddin
Bashoo
B
Matsumoto
Shinichi
S
Noguchi
Hirofumi
H
Shimoda
Masayuki
M
Chujo
Daisuke
D
Itoh
Takeshi
T
Sugimoto
Koji
K
Onaca
Nicholas
N
Lamont
Jeffrey
J
Lara
Luis F
LF
Levy
Marlon F
MF
D000328:Adult; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D050500:Pancreatitis, Chronic / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography