title: Characteristic time scales of electroencephalograms of narcoleptic patients and healthy controls.
abstract: Sleep electroencephalograms (EEGs) typically showed correlated fluctuations that became random-like oscillations beyond a characteristic time scale. To investigate this behavior quantitatively, the detrended fluctuation analysis (DFA) was applied to EEGs of 10 narcoleptic patients (22.0 ± 4.0 yrs; 6 males) and 8 healthy controls (24.0 ± 2.0 yrs; 5 males). The characteristic time scales of the narcoleptics and controls were estimated as 1.8 ± 0.7 and 4.4 ± 1.2s, respectively (significance level, p<0.01). We further performed DFA of the EEGs segmented into 30s epochs and found that the DFA scaling exponents increased in deep sleep stages. These results were verified with power spectrum and auto-correlation analysis, and reproduced by a mathematical model. We thus concluded that characteristics of EEGs of narcoleptic patients could be differentiated from those of healthy subjects, suggesting a potential application of DFA in diagnosing narcolepsy.
authors.affiliation: School of Physics, The University of Sydney, Sydney, New South Wales 2006, Australia. jongwon.kim@sydney.edu.au
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Hongbeom
authors.initials: H
authors.lastname: Shin
authors.forename: Eui-Joong
authors.initials: EJ
authors.lastname: Kim
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Koo
authors.forename: Byunghun
authors.initials: B
authors.lastname: Choi
authors.forename: Kwang Suk
authors.initials: KS
authors.lastname: Park
authors.forename: Do-Un
authors.initials: DU
authors.lastname: Jeong
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D016022:Case-Control Studies; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009290:Narcolepsy / Q000175:diagnosis*; D012815:Signal Processing, Computer-Assisted; D018709:Statistics, Nonparametric