title: cAMP diffusion in Dictyostelium discoideum: a Green's function method.
abstract: A Green's function method is developed to approach the spatiotemporal equations describing the cAMP production in Dictyostelium discoideum, markedly reducing numerical calculations times: cAMP concentrations and gradients are calculated just at the amoeba locations. A single set of parameters is capable of reproducing the different observed behaviors, from cAMP synchronization, spiral waves and reaction-diffusion patterns to streaming and mound formation. After aggregation, the emergence of a circular motion of amoebas, breaking the radial cAMP field symmetry, is observed.
authors.affiliation: Instituto de Física, Universidade Federal do Rio Grande do Sul, Av Bento Gonçalves 9500, PB 15051, 91501-970 Porto Alegre, RS, Brazil.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Calovi
authors.forename: Leonardo G
authors.initials: LG
authors.lastname: Brunnet
authors.forename: Rita M C
authors.initials: RM
authors.lastname: de Almeida
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D000242:Cyclic AMP / Q000737:chemistry*; D004023:Dictyostelium / Q000737:chemistry*; D008954:Models, Biological; D008956:Models, Chemical
chemical_list: D000242:Cyclic AMP