Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy.
Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.
Dierksen
Gregory A
GA
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Skehan
Maureen E
ME
Khan
Muhammad A
MA
Jeng
Jed
J
Nandigam
R N Kaveer
RN
Becker
John A
JA
Kumar
Ashok
A
Neal
Krista L
KL
Betensky
Rebecca A
RA
Frosch
Matthew P
MP
Rosand
Jonathan
J
Johnson
Keith A
KA
Viswanathan
Anand
A
Salat
David H
DH
Greenberg
Steven M
SM
D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D016657:Cerebral Amyloid Angiopathy / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D013844:Thiazoles