The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector--the selectors derived from two D-tartrates.
(2S,3S)-2,3-Bis(3,5-dimethylphenylcarbonyloxy)-3-(benzyloxycarbonyl)-propanoic acid and (2S,3S)-2,3-bis(1-naphthalenecarbonyloxy)-3-(benzyloxycarbonyl)-propanoic acid were synthesized from D-tartaric acid. These two compounds were chlorinated to afford two chiral selectors for chiral stationary phases (CSPs). The selectors were separately immobilized on aminated silica gel to give two single selector CSPs; and were simultaneously immobilized to obtain a mixed selector CSP. Comparing to the single selector CSPs, the mixed selector CSP bears the enhanced enantioseparation ability, suggesting that the two selectors in the mixed selector CSP are consistent for chiral recognition in most mobile phase conditions.
Chen
Jun
J
Key Laboratory of Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, China.
Li
Mu-Zi
MZ
Xiao
Yan-Hua
YH
Chen
Wei
W
Li
Shi-Rong
SR
Bai
Zheng-Wu
ZW
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D055601:Organic Chemistry Phenomena; D011437:Propylamines; D012821:Silanes / Q000737:chemistry; D058428:Silica Gel / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013644:Tartrates / Q000737:chemistry*
D011437:Propylamines; D012821:Silanes; D013644:Tartrates; D058428:Silica Gel; C477625:amino-propyl-triethoxysilane; C029768:tartaric acid