title: Artificial transcription factors which mediate double-strand DNA cleavage.
abstract: A new family of artificial transcription factor (ATF)-based conjugates have been designed and synthesized as potent chemical nucleases. Polyamides as the important and efficient ATFs were used to modify and activate several anchor compounds. The results demonstrate that the resulting conjugates remarkably promote the rate accelerations and non-random double-strand DNA cleavage activity. Interestingly, the cleavage activity of both the hydrolytic and oxidative agents was promoted efficiently through the modification of the ATFs.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 Beisanhuan East Road, 100029 Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Du
authors.forename: Hua
authors.initials: H
authors.lastname: Tian
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang
authors.forename: Min
authors.initials: M
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Ren-Zhong
authors.initials: RZ
authors.lastname: Qiao
authors.forename: Yan-Xing
authors.initials: YX
authors.lastname: Jia
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D015195:Drug Design; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009757:Nylons / Q000737:chemistry*; D010084:Oxidation-Reduction; D014157:Transcription Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009757:Nylons; D014157:Transcription Factors; D004247:DNA