Effects of triclocarban on intact immature male rat: augmentation of androgen action.
Triclocarban (TCC; 3,4,4'-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on human prostate LNCaP and C4-2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC treatment. In prostate cancer-derived LNCaP and C4-2B cells, TCC potentiated androgen actions via androgen receptor-dependent actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells.
Duleba
Antoni J
AJ
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA. ajduleba@ucdavis.edu
Ahmed
Mohamed I
MI
Sun
Meng
M
Gao
Allen C
AC
Villanueva
Jesus
J
Conley
Alan J
AJ
Turgeon
Judith L
JL
Benirschke
Kurt
K
Gee
Nancy A
NA
Chen
Jiangang
J
Green
Peter G
PG
Lasley
Bill L
BL
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002224:Carbanilides / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000378:metabolism; D012741:Sexual Maturation / Q000187:drug effects; D013739:Testosterone / Q000097:blood*; D014158:Transcription, Genetic / Q000187:drug effects; D014867:Water / Q000378:metabolism
D000891:Anti-Infective Agents, Local; D002224:Carbanilides; D011944:Receptors, Androgen; D014867:Water; D013739:Testosterone; D007986:Luteinizing Hormone; C009540:triclocarban