title: Endometrial adenocarcinoma with signet ring cells: report of two cases of an extremely rare phenomenon.
abstract: The presence of signet ring cells in a carcinoma within the uterine corpus strongly raises the possibility of a metastasis from a primary tumor in the breast, gastrointestinal tract, or elsewhere. Signet ring cells are extremely rare in primary endometrial adenocarcinomas with only a single prior case report. We report 2 cases of primary endometrial adenocarcinoma, one of mucinous and the other of endometrioid type, with a significant component of signet ring cells. One of the neoplasms arose within adenomyosis. In reporting these cases, we illustrate that the presence of signet ring cells does not preclude a primary endometrial adenocarcinoma.We discuss signet ring cells in the endometrium.
authors.affiliation: Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland.
authors.forename: Clinton
authors.initials: C
authors.lastname: Boyd
authors.forename: Iain
authors.initials: I
authors.lastname: Cameron
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged