title: Trichosporon inkin Esophagitis: An Uncommon Disease in a Patient with Pulmonary Cancer.
abstract: Trichosporon species are usually opportunistic pathogens. Here, we present a case of esophagitis caused by T. inkin in a 54-year-old woman with pulmonary cancer and severe neutropenia in whom the susceptibility profile of the isolate against azoles and polyenes was verified. The patient was diagnosed with esophagitis grade I of Wilcox, presenting scattered whitish plaques and exudates in upper two-thirds of the esophageal mucosa. Antifungal therapy involving oral fluconazole (150 mg/day for 14 days) was ineffective. In vitro, the isolate showed no resistance to this azole and sensitivity to amphotericin B. Since T. inkin is of growing importance as an agent of invasive infections in immunocompromised patients, we stress that the diagnosis of esophagitis by this species should be followed by an assessment of the therapeutic sensitivity of the strain involved.
authors.affiliation: Departamento de Micologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Nelson Chaves, s/n, Cidade Universitária, Recife, PE, 50670-420, Brazil. danielle_xande@yahoo.com.br
authors.forename: Danielle Patrícia Cerqueira
authors.initials: DP
authors.lastname: Macêdo
authors.forename: Neiva Tinti
authors.initials: NT
authors.lastname: de Oliveira
authors.forename: Vanessa Karina Alves
authors.initials: VK
authors.lastname: da Silva
authors.forename: Aline Mary
authors.initials: AM
authors.lastname: de Almeida Farias
authors.forename: Reginaldo Gonçalves
authors.initials: RG
authors.lastname: de Lima Neto
authors.forename: Ana Botler
authors.initials: AB
authors.lastname: Wilheim
authors.forename: Patrícia Cariolano
authors.initials: PC
authors.lastname: de Oliveira
authors.forename: Nadyr
authors.initials: N
authors.lastname: Pedi
authors.forename: Suanni Lemos
authors.initials: SL
authors.lastname: de Andrade
authors.forename: Rejane Pereira
authors.initials: RP
authors.lastname: Neves
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology; D004941:Esophagitis / Q000382:microbiology* / Q000473:pathology*; D004945:Esophagoscopy; D004947:Esophagus / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008175:Lung Neoplasms / Q000150:complications; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis* / Q000473:pathology*; D009503:Neutropenia / Q000150:complications; D011090:Polyenes / Q000494:pharmacology; D017211:Treatment Failure; D014250:Trichosporon / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D011090:Polyenes