Rapid synthesis of 2',3'-dideoxy-3'β-fluoro-pyrimidine nucleosides from 2'-deoxypyrimidine nucleosides.
A rapid synthesis of 2',3'-dideoxy-3'-fluoro-β-D-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral drugs. However, when evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.
Khalil
Ahmed
A
Institut des Biomolécules Max Mousseron, UMR CNRS-UM, Université Montpellier, France.
Mathé
Christophe
C
Périgaud
Christian
C
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D054879:Halogenation; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014777:Virus Diseases / Q000188:drug therapy; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides