Stratifying patients with stroke in trials that target brain repair.
A number of therapies are emerging that have the potential to reduce poststroke disability by promoting repair. Careful evaluation of patients with stroke might help distinguish those who are most likely to respond to a restorative therapy from those who lack biological substrate needed to achieve gains. Potential approaches to such stratification are considered, including measures of brain injury or of poststroke brain function.
Cramer
Steven C
SC
University of California Irvine Medical Center, Orange, CA 92868-4280, USA. scramer@uci.edu
D001921:Brain / Q000503:physiopathology; D002986:Clinical Trials as Topic; D006801:Humans; D018579:Patient Selection; D020127:Recovery of Function; D012107:Research Design; D020521:Stroke / Q000503:physiopathology; D000071939:Stroke Rehabilitation