Carrier mediated protein and peptide stabilization.
Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role in stabilization of proteins. Incorporation of the protein and peptides into a particulate carrier can protect it against degradation in vitro and in vivo, the release can be controlled,and it also offers possibilities for targeting. This review has focused on a wide range of bioactive carriers used in protein stabilization during long time storage. Bioactive carriers can protect the bioactives from degradation, resulting in increased bioavailability of protein.
Tiwari
Amit Kumar
AK
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University,Sagar-470 003, India.
Gajbhiye
Virendra
V
Sharma
Rajeev
R
Jain
Narendra Kumar
NK
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D050091:Dendrimers; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D008081:Liposomes; D008863:Microspheres; D053758:Nanoparticles; D037742:Nanotubes, Carbon; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
D003692:Delayed-Action Preparations; D050091:Dendrimers; D004337:Drug Carriers; D005079:Excipients; D008081:Liposomes; D037742:Nanotubes, Carbon; D010455:Peptides; D011506:Proteins