Intravenous lacosamide for treatment of status epilepticus.
OBJECTIVE
Treatment of established status epilepticus (SE) requires immediate intravenous anticonvulsant therapy. Currently used first-line drugs may cause potentially hazardous side effects. We aimed to assess the efficacy and safety of intravenous lacosamide (LCM) in SE after failure of standard treatment.


METHODS
We retrospectively analyzed 39 patients (21 women, 18 men, median age 62 years) from the hospital databases of five neurological departments in Germany, Austria and Switzerland between September 2008 and January 2010 who were admitted in SE and received at least one dose of intravenous LCM.


RESULTS
Types of SE were generalized convulsive (n = 6), complex partial (n = 17) and simple partial (n = 16). LCM was administered after failure of benzodiazepins or other standard drugs in all but one case. Median bolus dose of LCM was 400 mg (range 200-400 mg), which was administered at 40-80 mg/min in those patients where infusion rate was documented. SE stopped after LCM in 17 patients, while 22 patients needed further anticonvulsant treatment. The success rate in patients receiving LCM as first or second drug was 3/5, as third drug 11/19, and as fourth or later drug 3/15. In five subjects, SE could not be terminated at all. No serious adverse events attributed to LCM were documented.


CONCLUSIONS
Intravenous LCM may be an alternative treatment for established SE after failure of standard therapy, or when standard agents are considered unsuitable.
Kellinghaus
C
C
Department of Neurology, Klinikum Osnabrück, Germany. christoph.kellinghaus@klinikum-os.de
Berning
S
S
Immisch
I
I
Larch
J
J
Rosenow
F
F
Rossetti
A O
AO
Tilz
C
C
Trinka
E
E
D000081:Acetamides / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000379:methods; D000078334:Lacosamide; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide