title: The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features.
abstract: In a series of 177 breast carcinomas, we found that the Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status, and the three components of the Nottingham tumor grade. The RS also correlated with a composite index (the Breast Cancer Prognostic Score or BCPS) comprising the same six parameters. Categorical concordance was 56% and 66% using conventional and TAILORx cutoffs, respectively. Our data show that a composite prognostic index can be constructed from routinely reported breast tumor features that captures much of the information provided by the Oncotype assay at no added cost.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA. joseph.geradts@duke.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Geradts
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Bean
authors.forename: Rex C
authors.initials: RC
authors.lastname: Bentley
authors.forename: William T
authors.initials: WT
authors.lastname: Barry
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human