Anterior uveitis associated with high-dose cytosine arabinoside.
OBJECTIVE
To report a case of anterior uveitis associated with high-dose cytosine arabinoside (Ara-C) treatment.


METHODS
Observational case report.


METHODS
A 14-year-old girl was seen for pain, redness, and photophobia shortly after finishing a cycle of high-dose Ara-C.


RESULTS
Portable slit-lamp examination revealed bilateral diffuse fine keratic precipitates, indicative of a nongranulomatous anterior uveitis. This was treated successfully with a course of topical prednisolone acetate 1%.


CONCLUSIONS
Ophthalmologists who are asked to evaluate patients on high-dose Ara-C for a "red eye" should consider anterior uveitis as a potential diagnosis.
Fintelmann
Robert E
RE
The Francis I. Proctor Foundation and Department of Ophthalmology, University of California-San Francisco, San Francisco, California 4143-0730, USA.
Qian
Ying
Y
Skalet
Alison
A
Jeng
Bennie H
BH
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects*; D003561:Cytarabine / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives; D016896:Treatment Outcome; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; C009935:prednisolone acetate; D011239:Prednisolone