title: Evaluation of genotoxic effects in male Wistar rats following microwave exposure.
abstract: Wistar rats (70 days old) were exposed for 2 h a day for 45 days continuously at 10 GHz [power density 0.214 mW/cm2, specific absorption rate (SAR) 0.014 W/kg] and 50 GHz (power density 0.86 microW/cm2, SAR 8.0 x10(-4) W/kg). Micronuclei (MN), reactive oxygen species (ROS), and antioxidant enzymes activity were estimated in the blood cells and serum. These radiations induce micronuclei formation and significant increase in ROS production. Significant changes in the level of serum glutathione peroxidase, superoxide dismutase and catalase were observed in exposed group as compared with control group. It is concluded that microwave exposure can be affective at genetic level. This may be an indication of tumor promotion, which comes through the overproduction of reactive oxygen species.
authors.affiliation: Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kumar
authors.forename: Kavindra Kumar
authors.initials: KK
authors.lastname: Kesari
authors.forename: Jitendra
authors.initials: J
authors.lastname: Behari
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D004249:DNA Damage / Q000528:radiation effects*; D005434:Flow Cytometry; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D008872:Microwaves; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase