[The effects of intravenous dexketoprofen on postoperative analgesia and morphine consumption in patients undergoing abdominal hysterectomy].
OBJECTIVE
Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug ketoprofen. The aim of this study was to investigate the effect of intravenous dexketoprofen on postoperative pain.


METHODS
This study was performed on 50 (ASA I-II) patients scheduled for abdominal hysterectomy. Fifty patients were randomized into two equal groups. Patients received saline solution (Group I) or 50 mg intravenous dexketoprofen (Group II) 1 hour (h) before surgery and 8-16 h after surgery. All patients received a standard anesthetic protocol. At the end of surgery, all patients received intravenous (IV) morphine via a PCA (patient- controlled analgesia) device. Pain scores were assessed at 2, 6, 12 and 24 h after surgery. Morphine consumption and adverse effects were noted during the first 24 h after the surgery. The pain scores were significantly lower in the dexketoprofen group compared with the control group (p<0.05).


RESULTS
The cumulative morphine consumption was also lower in the dexketoprofen group than the control group (p<0.05). No significant difference was observed in adverse effects between the groups (p>0.05).


CONCLUSIONS
We conclude that the administration of IV dexketoprofen provided a significant analgesic benefit and decreased the morphine requirements in patients undergoing abdominal hysterectomy.
Tuncer
Sema
S
Department of Algology, Selçuk University Meram, Konya, Turkey. tuncersema@hotmail.com
Reisli
Ruhiye
R
Keçecioğlu
Melahat
M
Erol
Atilla
A
D000005:Abdomen / Q000601:surgery; D000698:Analgesia / Q000379:methods*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009020:Morphine / Q000627:therapeutic use*; D011184:Postoperative Period; D014325:Tromethamine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D009020:Morphine; D007660:Ketoprofen; C118296:dexketoprofen trometamol