Even neurons are excited by Th17 cells.
The mechanisms by which T helper 17 (Th17) cells contribute to autoimmune encephalomyelitis are likely diverse and not fully elucidated. In this issue of Immunity, Siffrin et al. (2010) propose that Th17 cells engage in direct interactions with neurons, leading to neuronal dysfunction and exacerbation of disease.
Egen
Jackson G
JG
Department of Immunology, Genentech, South San Francisco, CA 94080, USA.
Ouyang
Wenjun
W