[Efficacy of fluoroquinolones on urological infection pathogens within biofilms].
Our investigations demonstrated that fluoroquinalones affect both formation and established urological bacterial biofilms which present difficulties for antimicrobial therapy because incomplete eradication of uroinfection promotes persistence and development of chronic processes. Fluoroquinalones reduce biofilm mass and number of CFU. The affected biofilms become less resistant to external impacts. This provides a more potent action of antibiotic and, finally, a good therapeutic effect of the drug. Levofloxacin (floracid) showed the highest activity among fluoroquinalones studied. It actively suppresses uroinfection bacteria in biofilms and lowers the risk of the infection recurrence.
Tets
V V
VV
Artemenko
N K
NK
Zaslavskaia
N V
NV
Tets
G V
GV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D024841:Fluoroquinolones / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D014570:Urologic Diseases / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones