An engineering intervention resulting in improvement in lung function and change in urinary 8-hydroxydeoxyguanosine among foundry workers in Taiwan.
OBJECTIVE
To assess changes in oxidative DNA damage and lung function amongst a group of foundry workers resulting from an engineering intervention to reduce air respirable dust in their working environment.


METHODS
We studied all 22 workers recruited from a typical small Taiwanese iron foundry plant before and 3 months after improvements to air exhaust control. The effectiveness of the air exhaust intervention in reducing respirable dust and SiO₂ was determined by personal breathing-zone air sampling. Initial baseline biomarker measurements were taken of lung function and urinary 8-hydroxy-deoxyguanosine (8-OHdG) in all of the workers, with follow-up measurements taken 3 months after the engineering control was put in place. Generalized estimating equations were used to assess the effect of the intervention on lung function and oxidative DNA damage.


RESULTS
Following the intervention, respirable dust density decreased from 2.87 ± 1.38 mg/m³ to 1.60 ± 0.70 mg/m³ (p = 0.07), and SiO₂ concentration decreased from 0.43 ± 0.25 mg/m³ to 0.18 ± 0.11 mg/m³ (p < 0.05). Compared to initial baseline, significant improvements were found in lung function (FVC, FEV1, FVC%pred and FEV1%pred) amongst the workers after the engineering intervention. A significant increase in concentration of urinary 8-OHdG was observed after the engineering intervention in smokers, but not in non-smokers.


CONCLUSIONS
These findings indicate that reductions in workplace respirable dust and SiO₂ concentration can result in improved lung function amongst foundry workers.
Lin
Ming-Hsiu
MH
Institute of Occupational Safety and Health, Council of Labour Affairs, Executive Yuan, Taipei, 221, Taiwan, R.O.C.
Liou
Saou-Hsing
SH
Chang
Ching-Wen
CW
Huang
I-Hsiao
IH
Strickland
Paul T
PT
Lai
Ching-Huang
CH
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000395:Air Pollutants, Occupational; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004391:Dust; D004738:Engineering; D005541:Forced Expiratory Volume; D006801:Humans; D007501:Iron / Q000633:toxicity*; D008168:Lung / Q000502:physiology*; D008669:Metallurgy; D008875:Middle Aged; D016273:Occupational Exposure; D018384:Oxidative Stress; D011009:Pneumoconiosis; D012822:Silicon Dioxide / Q000009:adverse effects*; D012907:Smoking; D013147:Spirometry; D013624:Taiwan; D014797:Vital Capacity
D000395:Air Pollutants, Occupational; D004391:Dust; D012822:Silicon Dioxide; D000080242:8-Hydroxy-2'-Deoxyguanosine; D007501:Iron; D003849:Deoxyguanosine