Molecular analysis of gene rearrangements and mutations in acute leukemias and myeloproliferative neoplasms.
A large subset of acute leukemias and other myeloproliferative neoplasms contain specific genetic alterations, many of which are associated with unique clinical and pathologic features. These alterations include chromosomal translocations leading to oncogenic fusion genes, as well as mutations leading to aberrant activation of a variety of proteins critical to hematopoietic progenitor cell proliferation and differentiation. Molecular analysis is central to diagnosis and clinical management of leukemias, permitting genetic confirmation of a clinical and histologic impression, providing prognostic and predictive information, and facilitating detection of minimal residual disease. This unit will outline approaches to the molecular diagnosis of the most frequent and clinically relevant genetic alterations in acute leukemias and myeloproliferative neoplasms.
Sholl
Lynette M
LM
Brigham and Women's Hospital, Boston, Massachusetts, USA.
Longtine
Janina
J
D000208:Acute Disease; D002454:Cell Differentiation; D049109:Cell Proliferation; D015321:Gene Rearrangement; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000235:genetics*; D018365:Neoplasm, Residual / Q000235:genetics; D011379:Prognosis; D014178:Translocation, Genetic