title: Image dissimilarity-based quantification of lung disease from CT.
abstract: In this paper, we propose to classify medical images using dissimilarities computed between collections of regions of interest. The images are mapped into a dissimilarity space using an image dissimilarity measure, and a standard vector space-based classifier is applied in this space. The classification output of this approach can be used in computer aided-diagnosis problems where the goal is to detect the presence of abnormal regions or to quantify the extent or severity of abnormalities in these regions. The proposed approach is applied to quantify chronic obstructive pulmonary disease in computed tomography (CT) images, achieving an area under the receiver operating characteristic curve of 0.817. This is significantly better compared to combining individual region classifications into an overall image classification, and compared to common computerized quantitative measures in pulmonary CT.
authors.affiliation: The Image Group, Department of Computer Science, University of Copenhagen, Denmark. lauges@diku.dk
authors.forename: Lauge
authors.initials: L
authors.lastname: Sørensen
authors.forename: Marco
authors.initials: M
authors.lastname: Loog
authors.forename: Pechin
authors.initials: P
authors.lastname: Lo
authors.forename: Haseem
authors.initials: H
authors.lastname: Ashraf
authors.forename: Asger
authors.initials: A
authors.lastname: Dirksen
authors.forename: Robert P W
authors.initials: RP
authors.lastname: Duin
authors.forename: Marleen
authors.initials: M
authors.lastname: de Bruijne
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D013902:Radiography, Thoracic / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*