Methods of chromatographic determination of medicines decreasing the level of cholesterol.
With reference to common application of HPLC to routine analytical tests on medicinal products decreasing the level of cholesterol, including three compounds from this group--fenofibrate, bezafibrate and etofibrate, we developed a new method for determining two other compounds--ciprofibrate and gemfibrozil. The developed HPLC method may be used for identification and qualitative determination of selected compounds--derivatives of aryloxyalkylcarboxylic acids as well as it may be used for simultaneous separation and determination of all compounds from the group of fibrates using one column and the same methodology. The results and statistical data indicate good sensitivity and precision. The RSD value presented is equivalent to the newly developed method of determinination of ciprofibrate and gemfibrozil in the substances and medicinal products--capsules and coated tablets.
Kublin
Elzbieta
E
Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chełmska St., 00-725 Warszawa, Poland. elakublin@il.waw.pl
Kaczmarska-Graczyk
Barbara
B
Malanowicz
Ewa
E
Mazurek
Aleksander P
AP
D000924:Anticholesteremic Agents / Q000032:analysis*; D001629:Bezafibrate / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002995:Clofibric Acid / Q000031:analogs & derivatives / Q000032:analysis; D011345:Fenofibrate / Q000032:analysis; D058607:Fibric Acids; D015248:Gemfibrozil / Q000032:analysis
D000924:Anticholesteremic Agents; D058607:Fibric Acids; C009746:etofibrate; D002995:Clofibric Acid; C019304:ciprofibrate; D015248:Gemfibrozil; D011345:Fenofibrate; D001629:Bezafibrate