title: [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].
abstract: OBJECTIVE
  To develop a HPLC method for the simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao' erjinning oral liquid.
  
  
  METHODS
  The chromatographic separation was achieved on a Lichrospher C18 (4.6 mm x 250 mm, 5 microm) column with a mobile phase which was composed of acetonitrile(A) and 0.4% phosphoric acid(B) for gradient elution (10:90-18:82-27:73). The flow rate was (0.8-1.1-0.8) mL x min(-1), the column temperature was 30 degrees C and the detection wavelength was set at 300 nm.
  
  
  RESULTS
  The results showed that 6 effective components were separated well and showed good linearity. The average recoveries were between 95%-105%.
  
  
  CONCLUSIONS
  The method is proved to be rapid, accurate, credible and repeatable. It can be used for the quality control of Xiao'erjinning oral liquid.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xinzhuang
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhao
authors.forename: Liuqing
authors.initials: L
authors.lastname: Di
authors.forename: Qing
authors.initials: Q
authors.lastname: Guo
authors.forename: Shouchuan
authors.initials: S
authors.lastname: Wang
mesh_terms: D002109:Caffeic Acids / Q000032:analysis*; D002726:Chlorogenic Acid / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D044950:Flavanones / Q000032:analysis*; D006027:Glycosides / Q000032:analysis*; D006569:Hesperidin / Q000032:analysis*
chemical_list: D002109:Caffeic Acids; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D006027:Glycosides; D002726:Chlorogenic Acid; D006569:Hesperidin; C008282:linarin; C005274:naringin; C040048:caffeic acid