title: Vincristine-ticlopidine-aspirin: an effective therapy in children with Kasabach-Merritt phenomenon associated with vascular tumors.
abstract: Kasabach-Merritt phenomenon (KMP) is a serious coagulopathy with severe thrombocytopenia (<10,000/mm³) that occurs in the presence of an enlarging vascular tumor such as kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). The natural history and treatment of these lesions remain controversial. The authors report a KHE case and a TA case that presented with KMP, describing their successful pharmacological management with vincristine, ticlopidine, and aspirin.
authors.affiliation: Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, Sevilla, Spain. israfdez@hotmail.com
authors.forename: Israel
authors.initials: I
authors.lastname: Fernandez-Pineda
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Lopez-Gutierrez
authors.forename: Gema
authors.initials: G
authors.lastname: Ramirez
authors.forename: Catalina
authors.initials: C
authors.lastname: Marquez
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D018324:Hemangioma, Capillary / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D059885:Kasabach-Merritt Syndrome; D013988:Ticlopidine / Q000627:therapeutic use*; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D014750:Vincristine; D013988:Ticlopidine; D001241:Aspirin