Window to the brain: Can retinopathy be used to assess cognitive function.
OBJECTIVE
Retinopathy status as a screening method to predict cognitive health is limited. The objective of this study was to examine the association between retinopathy and lowered cognitive performance in a Canadian First Nations population.


METHODS
Eligible individuals were assessed by the Clock Drawing Test (CDT) and the Trail Making Test Parts A and B, which were combined into an executive function score (TMT-exec). Digital fundus photographs were taken for both eyes to assess retinopathy. Anthropometric, vascular and metabolic risk factors were assessed by interview, clinical examinations and blood tests. Carotid atherosclerosis was assessed by Doppler ultrasonography.


RESULTS
Retinopathy was detected in 7.1% of the population. Individuals classified as having a previous history of cardiovascular disease, insulin resistance and diabetes were more likely to have retinopathy. No other cardiovascular risk factors were associated. In unadjusted analysis, there were no associations between retinopathy and lowered cognitive performance (CDT, odds ratio [OR]: 0.86, 95% confidence interval [CI]: 0.30–2.53; TMT-exec, OR: 1.79, 95% CI: 0.60–5.33). Multivariable adjusted analysis also showed no associations, although sample size may be limiting.


CONCLUSIONS
Retinopathy was not associated with lowered cognitive performance. Associations for microvascular risk factors suggest a panel of cognitive tests is needed for future studies.
Fergenbaum
Jennifer H
JH
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. jennifer.fergenbaum@utoronto.ca
Bruce
Sharon
S
Lou
Wendy
W
Hanley
Anthony J G
AJ
Greenwood
Carol
C
Young
T Kue
TK
D000328:Adult; D000886:Anthropometry; D002170:Canada; D002318:Cardiovascular Diseases / Q000150:complications* / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012164:Retinal Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012307:Risk Factors; D013647:Task Performance and Analysis; D014145:Trail Making Test