title: Age-related normogram for antral follicle count: McGill reference guide.
abstract: OBJECTIVE
  To produce age-related normograms for antral follicle count in an infertile population without polycystic ovaries.
  
  
  METHODS
  Retrospective cohort analysis.
  
  
  METHODS
  University teaching center.
  
  
  METHODS
  Eighteen hundred sixty-six infertile patients.
  
  
  METHODS
  Baseline transvaginal ultrasound examination between days 2 and 4 of the menstrual cycle.
  
  
  METHODS
  Correlation between age and different percentiles of antral follicle count.
  
  
  RESULTS
  The age-related normogram for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentile of antral follicle count showed a biphasic mode of antral follicle count decline with two different rates of antral follicle count loss: a steep-slope phase (high rate of antral follicle count loss) and a moderate-slope phase (restrained rate of antral follicle count losses). In the low antral follicle count percentiles (3rd, 10th, 25th), the phase of high loss rate of follicles preceded the phase of slow loss rate, whereas in the high antral follicle count percentiles (75th, 90th, 97th) the opposite was found.
  
  
  CONCLUSIONS
  Age-related normograms in infertile women without polycystic ovaries demonstrate a biphasic pattern of decreased antral follicles. These normograms could provide a reference guide for the clinician in consulting with women with infertility. However, future validation with longitudinal data is still needed.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: Benny
authors.initials: B
authors.lastname: Almog
authors.forename: Fady
authors.initials: F
authors.lastname: Shehata
authors.forename: Einat
authors.initials: E
authors.lastname: Shalom-Paz
authors.forename: Seang Lin
authors.initials: SL
authors.lastname: Tan
authors.forename: Togas
authors.initials: T
authors.lastname: Tulandi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D002452:Cell Count / Q000379:methods / Q000592:standards; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D049451:Nomograms; D006080:Ovarian Follicle / Q000166:cytology* / Q000000981:diagnostic imaging / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000473:pathology; D017410:Practice Guidelines as Topic; D012016:Reference Values; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult