[Experimental hemorrhagic stroke: the study of neuropeptides (MIF, selank) in the intraperitoneal injection].
The aim of this study was to examine Taftsin derivates--macrophage inhibitory factor (MIF, Thr-Lys-Pro) and heptapeptide selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the model of experimental intracerebral hemorrhage in rats. The double autologous blood injection in the basal nucleus was used as a model of intracerebral hemorrhage. Animals ware randomly divided into three groups--the control group (n = 5) was treated with saline, the second group (n = 5) was injected with MIF in dose 150 mkg/ kg/day, the third group (n = 5) received Selank in dose 300 mkg/kg/day. Intraperitoneal injection of peptides was used. Body weight assessment, neurological examination and brain MRI were performed in 24, 72 hours and 10 days after the hematoma formation. The effect of neuropeptides on the functional restoration in animals, in the absence of the effect on hematoma volume and perifocal edema, was found. The significant reduction of perifocal edema and hematoma volume was observed in the 10th day after the hematoma formation in all experimental groups (p < 0.05). Only the control group of animals showed the significant (p < 0.05) weight loss in the 3rd day after the operation. The rate of neurological deficit was different: the significant improvement assessed with Menzes and limb placing test scales was seen only in the groups treated with neuropeptides in the 10th day.
Skvortsova
V I
VI
Tvorogova
T V
TV
Dubina
A I
AI
Burenchev
D V
DV
Gubskiĭ
L V
LV
Stakhovskaia
L V
LV
Povarova
O V
OV
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008263:Macrophage Migration-Inhibitory Factors / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D009842:Oligopeptides / Q000008:administration & dosage*; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology; D014405:Tuftsin / Q000008:administration & dosage*
D008263:Macrophage Migration-Inhibitory Factors; D009842:Oligopeptides; C045468:threonyl-lysyl-proline; D014405:Tuftsin; C100827:TP 7