Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1.
We report here that YajL is associated with ribosomes and interacts with many ribosomal proteins and that a yajL mutant of Escherichia coli displays decreased translation accuracy, as well as increased dissociation of 70S ribosomes into 50S and 30S subunits after oxidative stress.
Kthiri
Fatoum
F
Stress Molecules, Institut Jacques Monod, Université Paris 7, 2 Place Jussieu, Paris, France.
Gautier
Valérie
V
Le
Hai-Tuong
HT
Prère
Marie-Françoise
MF
Fayet
Olivier
O
Malki
Abderrahim
A
Landoulsi
Ahmed
A
Richarme
Gilbert
G
D004926:Escherichia coli / Q000378:metabolism / Q000502:physiology*; D029968:Escherichia coli Proteins; D014176:Protein Biosynthesis; D012269:Ribosomal Proteins / Q000172:deficiency*; D012270:Ribosomes / Q000378:metabolism
D029968:Escherichia coli Proteins; D012269:Ribosomal Proteins; C554198:YajL protein, E coli