title: Coincidence of acute brucella hepatitis and dengue fever or serologic cross-reactivity?
abstract: Hepatic involvement in brucellosis is not uncommon since 10-20% of patient infected with brucella species can have abnormal liver function tests. The usual presentation of brucella hepatitis is in the form of chronic granulomatous hepatitis with mild to moderate elevation of liver enzymes, while acute hepatitis is rare. We report a young patient who presented with acute brucella-induced hepatitis and co-infection with dengue hemorrhagic virus resulting in severe elevation of liver enzymes and absence of granuloma on histology. His mother also simultaneously tested positive for both infections. The patient responded well to anti-brucella therapy with normalization of his liver profile. We discuss, herein, the hepatic involvement of these two infections and discuss the possible serological cross-reactivity between brucella and dengue fever virus.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia.
authors.forename: Khalid I
authors.initials: KI
authors.lastname: Bzeizi
authors.forename: Ali
authors.initials: A
authors.lastname: Benmousa
authors.forename: Faisal M
authors.initials: FM
authors.lastname: Sanai
mesh_terms: D000208:Acute Disease; D000328:Adult; D017347:Brucella melitensis; D002006:Brucellosis / Q000150:complications* / Q000175:diagnosis; D003429:Cross Reactions; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D012698:Serologic Tests; D019595:Severe Dengue / Q000150:complications* / Q000175:diagnosis; D055815:Young Adult