Phasic responses in dorsal raphe serotonin neurons to noxious stimuli.
Serotonin is widely implicated in aversive processing. It is not clear, however, whether serotonin neurons encode information about aversive stimuli. We found that, in the dorsal raphe of anesthetized rats, most neurochemically-identified clocklike serotonin neurons were phasically excited by noxious footshocks, whereas most bursting serotonin neurons were inhibited. These results suggest that discrete groups of serotonin neurons differentially code for aversive stimuli.
Schweimer
J V
JV
Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Ungless
M A
MA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004597:Electroshock / Q000009:adverse effects; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation / Q000009:adverse effects; D011903:Raphe Nuclei / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D012701:Serotonin; D014365:Tryptophan Hydroxylase