Chronic cutaneous graft-versus-host disease manifesting as calcinosis cutis universalis on a background of widespread sclerodermatoid changes.
BACKGROUND
The cutaneous manifestations of graft-versus-host disease (GVHD) can be classified into acute and chronic forms. Acute GVHD is defined as a skin eruption that manifests within 100 days of transplantation, whereas chronic GVHD refers to cutaneous changes that appear 100 days or more posttransplantation.


OBJECTIVE
Although most chronic forms fall within lichenoid and sclerodermoid forms, there is a multitude of less common presentations. These include xerosis, follicular prominence, ichthyosis, and pityriasis rosea-like, eczematous, or psoriasiform lesions.


CONCLUSIONS
We report a previously unreported manifestation of chronic cutaneous GVHD, specifically calcinosis cutis universalis on a background of sclerodermoid changes.
Man
Jeremy
J
Division of Dermatology, University of Alberta, Edmonton, Ab, Canada.
Kalisiak
Michal
M
Birchall
Iain W J
IW
Salopek
Thomas G
TG
D016026:Bone Marrow Transplantation / Q000276:immunology*; D002114:Calcinosis / Q000175:diagnosis*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000276:immunology*