Dynamics of inflammatory markers in post-acute stroke patients undergoing rehabilitation.
Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ2 = 4.81, p = 0.028, χ2 = 10.40, p = 0.005 and χ2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients' recovery.
Manolescu
Bogdan Nicolae
BN
Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, 8 Eroii Sanitari Street, Bucharest, Romania. manolescub@yahoo.fr
Berteanu
Mihai
M
Dumitru
Luminița
L
Dinu
Horațiu
H
Iliescu
Alina
A
Fărcășanu
Ileana Cornelia
IC
Oprea
Eliza
E
Vlădoiu
Suzana
S
Popa
Oana
O
Ianăș
Olga
O
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis*; D053582:Interleukin-1alpha / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D011379:Prognosis; D012046:Rehabilitation; D020521:Stroke / Q000097:blood / Q000175:diagnosis*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D053582:Interleukin-1alpha; D015850:Interleukin-6; D017270:Lipoprotein(a); D014409:Tumor Necrosis Factor-alpha