Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity.
Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.
Marcelin
Genevieve
G
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA.
Chua
Streamson
S
D017667:Adipocytes / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D051379:Mice; D023421:Models, Animal; D009765:Obesity / Q000378:metabolism* / Q000628:therapy; D010084:Oxidation-Reduction; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides