Cancer: miRNA addiction - depending on life's little things.
MicroRNAs (miRNAs) pleiotropically modulate gene expression in all cell types. Many miRNAs are overexpressed in tumors, and recent findings suggest that tumors can be 'addicted' to miRNA overexpression, yielding a possible therapeutic opportunity.
Dornan
David
D
Genentech, South San Francisco, CA 94080, USA.
Settleman
Jeff
J
D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes
D035683:MicroRNAs