Evaluation of genotoxic effects in male Wistar rats following microwave exposure.
Wistar rats (70 days old) were exposed for 2 h a day for 45 days continuously at 10 GHz [power density 0.214 mW/cm2, specific absorption rate (SAR) 0.014 W/kg] and 50 GHz (power density 0.86 microW/cm2, SAR 8.0 x10(-4) W/kg). Micronuclei (MN), reactive oxygen species (ROS), and antioxidant enzymes activity were estimated in the blood cells and serum. These radiations induce micronuclei formation and significant increase in ROS production. Significant changes in the level of serum glutathione peroxidase, superoxide dismutase and catalase were observed in exposed group as compared with control group. It is concluded that microwave exposure can be affective at genetic level. This may be an indication of tumor promotion, which comes through the overproduction of reactive oxygen species.
Kumar
Sanjay
S
Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
Kesari
Kavindra Kumar
KK
Behari
Jitendra
J
D000818:Animals; D002374:Catalase / Q000378:metabolism; D004249:DNA Damage / Q000528:radiation effects*; D005434:Flow Cytometry; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D008872:Microwaves; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase