Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis.
Cytokinesis is the final step of cell division whereby the dividing cells separate physically. Failure of this process has been proposed to cause tumourigenesis. Several specific lipids are essential for cytokinesis, and recent evidence has revealed that phosphatidylinositol 3-phosphate (PtdIns3P) - a well-known regulator of endosomal trafficking, receptor signaling, nutrient sensing and autophagy - plays an evolutionarily conserved role during cytokinesis. The emerging picture is that PtdIns3P and its regulators and effectors constitute a novel regulatory mechanism for cytokinesis. Elucidating the role of PtdIns3P in cytokinesis might contribute to insight into mechanisms of tumour development and suppression.
Nezis
Ioannis P
IP
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway.
Sagona
Antonia P
AP
Schink
Kay Oliver
KO
Stenmark
Harald
H
D000818:Animals; D048749:Cytokinesis; D005658:Fungi / Q000166:cytology; D006801:Humans; D008055:Lipids / Q000502:physiology; D018129:Phosphatidylinositol Phosphates / Q000502:physiology*; D059828:Plant Cells
D008055:Lipids; D018129:Phosphatidylinositol Phosphates