[Significance of plasmic L-plastin levels in the diagnosis of colorectal cancer].
OBJECTIVE
To investigate the clinical significance of plasmic L-plastin level in patients with colorectal cancer.


METHODS
From March 2008 to March 2009, plasma samples were collected from 40 patients and 40 healthy controls. Plasmic L-plastin level was measured by ELISA kit and was compared to TIMP-1.


RESULTS
Plasmic L-plastin level in patients with colorectal cancer was higher than that in healthy adults (1.662±0.386 vs. 0.485±0.085 μg/L, P<0.01). The sensitivity of L-plastin in the diagnosis of colorectal cancer was 67.5%, and the specificity was 80.6%. The Youden index was 0.481 and AUC was 0.772 (P<0.01). Plasmic L-plastin levels were associated with the tumor size (P=0.006), serosal penetration (F=4.687, P<0.05) and lymphatic metastasis (P<0.01). Compared to plasmic TIMP-1 level, L-plastin showed the same capability in indicating the depth of tumor. The specificity of L-plastin was better in indicating lymphatic metastasis (86% vs. 58%, χ2=4.2, P<0.05).


CONCLUSIONS
Plasmic L-plastin level may serve as a potential marker in colorectal cancer.
Yuan
Cheng-bin
CB
Department of General Surgery, Ruijin Hospital, Shanghai Jiaoton University, Shanghai 200025, China.
Zhao
Ren
R
Wan
Fang-jun
FJ
Cai
Jian-hua
JH
Ji
Xiao-pin
XP
Yu
Ying-yan
YY
D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008840:Microfilament Proteins / Q000097:blood*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; D019715:Tissue Inhibitor of Metalloproteinase-1; C026742:plastin