title: Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction.
abstract: Patas monkeys were not reported to carry species‐specific simian immunodeficiency virus (SIV), but cross‐species transmission of SIVagm to patas monkeys occurred in the wild. We report that patas monkeys share immunophenotypic features with natural hosts of SIV; that is, low levels of CD4+ T cells and low CCR5 expression on CD4+ T cells. In 1 patas monkey with undetectable levels of CD4+ T cells, experimental exposure to SIVagm did not result in infection. The other experimentally infected patas monkeys showed an infection pattern similar to SIV infection in natural hosts. Thus, down‐regulation of CD4 and CCR5 expression on CD4+ T cells may effectively control human immunodeficiency virus acquisition and result in SIV extinction.
authors.affiliation: Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA. apetreic@pitt.edu
authors.forename: Cristian
authors.initials: C
authors.lastname: Apetrei
authors.forename: Thaidra
authors.initials: T
authors.lastname: Gaufin
authors.forename: Rajeev
authors.initials: R
authors.lastname: Gautam
authors.forename: Carol
authors.initials: C
authors.lastname: Vinton
authors.forename: Vanessa
authors.initials: V
authors.lastname: Hirsch
authors.forename: Mark
authors.initials: M
authors.lastname: Lewis
authors.forename: Jason
authors.initials: J
authors.lastname: Brenchley
authors.forename: Ivona
authors.initials: I
authors.lastname: Pandrea
mesh_terms: D000818:Animals; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D004901:Erythrocebus patas; D005786:Gene Expression Regulation; D007113:Immunity, Innate; D010215:Papio; D019713:Receptors, CCR5 / Q000096:biosynthesis; D011991:Receptors, Virus / Q000096:biosynthesis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
chemical_list: D019713:Receptors, CCR5; D011991:Receptors, Virus