title: Effects of solid hyaluronic acid film on postoperative fibrous scar formation after strabismus surgery in animals.
abstract: OBJECTIVE
  The purpose of this study was to investigate the inhibitory effect of solid hyaluronic acid-carboxymethylcellulose film on the formation of wound adhesion after strabismus surgery on rabbit eyes.
  
  
  METHODS
  The authors performed strabismus surgery on rabbit eyes with hyaluronic acid film applied under and above the muscles. Histological examination was performed 90 days postoperatively using Masson trichrome staining. The length of adhesion tissues in the operated area was quantitatively compared between film-treated and control eyes.
  
  
  RESULTS
  Hyaluronic acid film significantly prevented the formation of adhesions between muscle, conjunctiva, and sclera after strabismus surgery (t test, P < .05).
  
  
  CONCLUSIONS
  The current results indicate that hyaluronic acid film can inhibit the formation of postoperative adhesion around conjunctiva, muscle, and sclera to some extent. The authors conclude that this substance offers potential benefits for ophthalmic surgery, not only with strabismus surgery but also procedures such as scleral buckle.
authors.affiliation: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Kimio
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakazawa
authors.forename: Tomomi
authors.initials: T
authors.lastname: Metoki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium; D002921:Cicatrix / Q000517:prevention & control*; D003229:Conjunctival Diseases / Q000517:prevention & control; D006820:Hyaluronic Acid; D008567:Membranes, Artificial; D009801:Oculomotor Muscles / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D015422:Scleral Diseases / Q000517:prevention & control; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium