title: The effect of propofol and desflurane anaesthesia on human hepatic blood flow: a pilot study.
abstract: This study tested the hypothesis that propofol is associated with a higher hepatic blood flow in humans compared with desflurane. Using a cross over study design, 10 patients received first propofol and then desflurane, and a further 10 patients received desflurane and then propofol. Blood flow index in the right and middle hepatic veins, stroke volume index and cardiac index were assessed by transoesophageal echocardiography. Mean arterial blood pressure, stroke volume index and cardiac index were the same in both groups. Propofol was associated with significantly greater blood flow index in the right hepatic vein (median (IQR [range]) 199 (146-237 [66-388]) vs. 149 (112-189 [42-309]) ml.min(-1).m(-2); p = 0.005) and middle hepatic vein (150 (122-191 [57-341]) vs. 125 (92-149 [47-362]) ml.min(-1).m(-2); p < 0.001) compared with desflurane. In routine clinical conditions, propofol anaesthesia was associated with significantly greater hepatic blood flow than desflurane anaesthesia.
authors.affiliation: Department of Anaesthesiology, University Clinic Ulm, Ulm, Germany. rainer.meierhenrich@uniklinik-ulm.de
authors.forename: R
authors.initials: R
authors.lastname: Meierhenrich
authors.forename: A
authors.initials: A
authors.lastname: Gauss
authors.forename: B
authors.initials: B
authors.lastname: Mühling
authors.forename: H
authors.initials: H
authors.lastname: Bracht
authors.forename: P
authors.initials: P
authors.lastname: Radermacher
authors.forename: M
authors.initials: M
authors.lastname: Georgieff
authors.forename: F
authors.initials: F
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D018592:Cross-Over Studies; D000077335:Desflurane; D017548:Echocardiography, Transesophageal; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006503:Hepatic Veins / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015742:Propofol / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000077335:Desflurane; D007530:Isoflurane; D015742:Propofol