The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease.
Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.
Weil
Brent R
BR
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. brweil@iupui.edu
Manukyan
Mariuxi C
MC
Herrmann
Jeremy L
JL
Abarbanell
Aaron M
AM
Poynter
Jeffrey A
JA
Wang
Yue
Y
Meldrum
Daniel R
DR
D003424:Crohn Disease / Q000503:physiopathology / Q000601:surgery; D006084:Graft Rejection / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology / Q000601:surgery; D018805:Sepsis / Q000503:physiopathology / Q000601:surgery