title: Vancomycin MIC for methicillin-resistant coagulase-negative Staphylococcus isolates: evaluation of the broth microdilution and Etest methods.
abstract: Vancomycin MIC results were determined by the broth microdilution (BMD) method and by Etest using 130 methicillin-resistant coagulase-negative staphylococcus bloodstream isolates obtained from a tertiary hospital. The majority (98.5%) of MIC results determined by BMD were ≤1 μg/ml, in contrast to MIC results determined by Etest (72.3% were ≥1.5 μg/ml). The MICs obtained by Etest were, in general, 1- to 2-fold higher than the MICs obtained by BMD.
authors.affiliation: Unidade de Microbiologia e Biologia Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 2350 Ramiro Barcelos Street, Porto Alegre 90035-903, RS, Brazil. rpaiva@hcpa.ufrgs.br
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Paiva
authors.forename: Alice B
authors.initials: AB
authors.lastname: Mombach Pinheiro Machado
authors.forename: Alexandre P
authors.initials: AP
authors.lastname: Zavascki
authors.forename: Afonso L
authors.initials: AL
authors.lastname: Barth
mesh_terms: D016470:Bacteremia / Q000382:microbiology*; D003030:Coagulase / Q000378:metabolism; D006761:Hospitals; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D013203:Staphylococcal Infections / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D003030:Coagulase; D014640:Vancomycin