title: Is the yolk sac a new marker for chromosomal abnormalities in early pregnancy?
abstract: BACKGROUND
  Abnormal yolk sac size is associated with fetal miscarriage. This is a case report of two pregnancies with abnormal yolk sacs.
  
  
  METHODS
  In one case, a twofold sac was found; in the other case, the yolk sac was not of spherical form.
  
  
  CONCLUSIONS
  Currently available publications demonstrate a correlation between abnormal yolk sac size and miscarriage. However, in both cases a trisomy was confirmed. It should therefore be discussed whether form and size of the yolk sac could be a marker for chromosomal abnormalities of the fetus.
authors.affiliation: Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany. info@dr-schmidt.info
authors.forename: Peter
authors.initials: P
authors.lastname: Schmidt
authors.forename: Cindy
authors.initials: C
authors.lastname: Hörmansdörfer
authors.forename: Stephan
authors.initials: S
authors.lastname: Bosselmann
authors.forename: Michael
authors.initials: M
authors.lastname: Elsässer
authors.forename: Alexander
authors.initials: A
authors.lastname: Scharf
mesh_terms: D000328:Adult; D015415:Biomarkers; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014314:Trisomy / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal; D015017:Yolk Sac / Q000002:abnormalities* / Q000000981:diagnostic imaging*
chemical_list: D015415:Biomarkers