title: Tumorigenesis: Twist1 links EMT to self-renewal.
abstract: The epithelial-mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.
authors.forename: Alberto
authors.initials: A
authors.lastname: Martin
authors.forename: Amparo
authors.initials: A
authors.lastname: Cano
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008648:Mesoderm / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009687:Nuclear Proteins / Q000378:metabolism; D063150:Polycomb Repressive Complex 1; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D051879:Twist-Related Protein 1 / Q000378:metabolism*
chemical_list: C069077:BMI1 protein, human; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D051879:Twist-Related Protein 1; D063150:Polycomb Repressive Complex 1