Plant-derived therapeutics for the treatment of metabolic syndrome.
Metabolic syndrome is defined as a set of coexisting metabolic disorders that increase an individual's likelihood of developing type 2 diabetes, cardiovascular disease and stroke. Medicinal plants, some of which have been used for thousands of years, serve as an excellent source of bioactive compounds for the treatment of metabolic syndrome because they contain a wide range of phytochemicals with diverse metabolic effects. In order for botanicals to be effectively used against metabolic syndrome, however, botanical preparations must be characterized and standardized through the identification of their active compounds and respective modes of action, followed by validation in controlled clinical trials with clearly defined endpoints. This review assesses examples of commonly known and partially characterized botanicals to describe specific considerations for the phytochemical, preclinical and clinical characterization of botanicals associated with metabolic syndrome.
Graf
Brittany L
BL
Rutgers University, SEBS, New Brunswick, NJ 08901, USA.
Raskin
Ilya
I
Cefalu
William T
WT
Ribnicky
David M
DM
D050153:Abdominal Fat / Q000187:drug effects; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D050171:Dyslipidemias / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D024821:Metabolic Syndrome / Q000188:drug therapy*; D051379:Mice; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D010944:Plants / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism; D051381:Rats
D028321:Plant Preparations