title: Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression.
abstract: OBJECTIVE
  To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava.
  
  
  METHODS
  Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection.
  
  
  RESULTS
  Dieckol treatment lengthened the survival of irradiated mice and significantly accelerated the hemopoietic recovery of bone marrow cells and peripheral immune cells compared with irradiated, but untreated controls. Dieckol also enhanced the proliferation and differentiation of immune cells, which had been suppressed by ionising radiation. It turned out that the increased expression of oxygen radical-scavenging enzyme manganese superoxide dismutase (MnSOD) and subsequent reduction in DNA damage and lipid peroxidation was crucial for dieckol's radioprotective effect. In addition, the dieckol-induced modulation of protein 53 (p53)-dependent pathways further strengthened the radioresistance of immune cells.
  
  
  CONCLUSIONS
  Dieckol can be a promising agent for reducing the time needed for reconstitution of hemopoietic cells after exposure to irradiation.
authors.affiliation: Jeju National University, South Korea.
authors.forename: Eunjin
authors.initials: E
authors.lastname: Park
authors.forename: Ginnae
authors.initials: G
authors.lastname: Ahn
authors.forename: Jin-Suk
authors.initials: JS
authors.lastname: Yun
authors.forename: Min Ju
authors.initials: MJ
authors.lastname: Kim
authors.forename: So Jin
authors.initials: SJ
authors.lastname: Bing
authors.forename: Dae Seung
authors.initials: DS
authors.lastname: Kim
authors.forename: Jehee
authors.initials: J
authors.lastname: Lee
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Youngheun
authors.initials: Y
authors.lastname: Jee
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001572:Benzofurans / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004249:DNA Damage; D016166:Free Radical Scavengers / Q000378:metabolism; D005720:Gamma Rays; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D007108:Immune Tolerance / Q000187:drug effects* / Q000528:radiation effects; D007165:Immunosuppression Therapy; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D001572:Benzofurans; D016166:Free Radical Scavengers; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; C503840:dieckol; D016178:Granulocyte-Macrophage Colony-Stimulating Factor