title: Altered engagement of attention and default networks during target detection in schizophrenia.
abstract: Recent studies have implicated inappropriate engagement of functional brain networks in schizophrenia. This fMRI study examined task-induced activations and deactivations in 10 schizophrenia patients with prominent negative symptoms and 10 healthy controls during a simple target detection task. Group comparison revealed recruitment of distinct attentional networks during this task, with schizophrenia subjects activating the dorsal attention system and controls activating the executive network. Further, schizophrenia patients failed to deactivate posterior cingulate regions during the task, supporting recent studies of altered default mode processing. These findings support theories of dysfunctional recruitment of large-scale brain networks in schizophrenia.
authors.affiliation: Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA. whasenk@emory.edu
authors.forename: Wendy
authors.initials: W
authors.lastname: Hasenkamp
authors.forename: G Andrew
authors.initials: GA
authors.lastname: James
authors.forename: William
authors.initials: W
authors.lastname: Boshoven
authors.forename: Erica
authors.initials: E
authors.lastname: Duncan
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003118:Color Perception / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D010101:Oxygen Consumption / Q000502:physiology*; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011597:Psychomotor Performance / Q000502:physiology*; D011999:Recruitment, Neurophysiological / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology