title: Altered cytokine production by dendritic cells from infants with atopic dermatitis.
abstract: Dendritic cells (DC) are potent initiators of immune responses, compared to other professional antigen-presenting cells, based on their ability to capture antigen, express high amounts of MHC and co-stimulatory molecules, and to secrete immunostimulatory cytokines. Altered functions of DC in atopic individuals have been observed, though it is not clear if this is a cause or a result of the development of allergic disease. In this report we demonstrate altered cytokine production by DC isolated from infants with atopic dermatitis but without a diagnosis of asthma, compared to infants with non-atopic dermatitis. Increased production of IL-6, IL-10 and IFNα from DC isolated from atopic infants is less apparent when DC from infants were examined 1 year later. An increase in the same cytokines was observed in neonatal mice that are genetically predisposed towards allergic inflammation. These results suggest that an atopic environment promotes altered cytokine production by DC from infants.
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Yao
authors.forename: JiHoon
authors.initials: J
authors.lastname: Chang
authors.forename: Sarita
authors.initials: S
authors.lastname: Sehra
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Travers
authors.forename: Cheong-Hee
authors.initials: CH
authors.lastname: Chang
authors.forename: Robert S
authors.initials: RS
authors.lastname: Tepper
authors.forename: Mark H
authors.initials: MH
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D003872:Dermatitis / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D050800:STAT6 Transcription Factor / Q000235:genetics; D013997:Time Factors
chemical_list: D016207:Cytokines; D016898:Interferon-alpha; D015850:Interleukin-6; D050800:STAT6 Transcription Factor; C494100:Stat6 protein, mouse; D016753:Interleukin-10