α7 and β2 nicotinic receptors control monoamine-mediated locomotor response.
Earlier studies reported exacerbated locomotor response to stress and tranylcypromine in β2 nicotinic acetylcholine receptor (nAChR) knockout (KO) mice. This study aimed to further assess the role of β2 and coexpressed nAChR subunits in the brain (α4, α6 and α7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments. Results show that β2 KO mice were hyperreactive to novelty, cocaine and morphine. In contrast, α7 KO mice were hyporeactive to tranylcypromine and cocaine. These results suggest that endogenous nAChR stimulation may exert a tonic control on monoamine-mediated locomotor responses. β2 and α7-containing nAChR may contribute, respectively, to the inhibitory and permissive pathways of this tonic control.
Villégier
Anne-Sophie
AS
INSERM U114, Collége de France, Paris. anne-sophie.villegier@ineris.fr
Salomon
Lucas
L
Granon
Sylvie
S
Champtiaux
Nicolas
N
Changeux
Jean-Pierre
JP
Tassin
Jean-Pol
JP
D017109:Akathisia, Drug-Induced / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D015306:Biogenic Monoamines / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D011595:Psychomotor Agitation / Q000378:metabolism* / Q000503:physiopathology; D011978:Receptors, Nicotinic / Q000502:physiology*; D064569:alpha7 Nicotinic Acetylcholine Receptor
D015306:Biogenic Monoamines; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; C579166:Chrna7 protein, mouse