title: Hemodynamics of ulcerated plaques: before and after.
abstract: The hemodynamics and fluid mechanical forces in blood vessels have long been implicated in the deposition and growth of atherosclerotic plaque. Detailed information about the hemodynamics in vessels affected by significant plaque deposits can also provide insight into the mechanisms and likelihood of plaque weakening and rupture. In the current study, the governing equations are solved in their finite volume formulation in several patient-specific stenotic geometries. Of specific interest are the flow patterns and forces near ulcerations in the plaque. The flow patterns and forces in vessels with ulcerated plaques are compared with those in stenotic vessels without evidence of ulceration and to the hemodynamics in the same vessels as they likely appeared prior to ulceration. Hemodynamics "before" and "after" hemorrhage may suggest fluid mechanical and morphological factors of diagnostic and predictive value. Recirculation zones, vortex shedding, and secondary flows are captured by both laminar and turbulent solutions. The forces on vessel walls are shown to correlate with unstable plaque deposits. Performing before and after studies of vessels in long-term radiology studies may illuminate mechanisms of hemorrhage and other vessel remodeling.
authors.affiliation: Department of Biology, Lafayette College, Easton, PA 18042, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Cummins
authors.forename: Jenn Stroud
authors.initials: JS
authors.lastname: Rossmann
mesh_terms: D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D003198:Computer Simulation; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000503:physiopathology*; D011673:Pulsatile Flow; D014456:Ulcer / Q000473:pathology / Q000503:physiopathology*