title: P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide.
abstract: Although suicide represents 1.8% of the global burden of disease, there are few objective assays for suicide risk. Being associated with depressive disorders, which have a high risk of suicide, the proteins P11, P2RX7, and S100β may be biomarkers for a suicidal disposition. We measured levels of p11 and P2RX7 mRNA in peripheral blood mononuclear cells (PBMCs) of 26 psychiatric patients (11 suicide attempters, 15 suicide non-attempters) with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), and 14 normal controls, using quantitative real-time PCR. We also conducted a meta-analysis of microarray data of p11, P2RX7 and S100β from post-mortem prefrontal cortex (PFC) of patients who committed suicide (n = 56) and non-suicide controls (n = 61). We found that PBMC p11 mRNA levels were significantly lower in suicide attempters and higher in suicide non-attempters, when compared to normal controls. The PFC p11 mRNA levels in suicide completers were also lower than non-suicide controls (adjusted p = 0.007). Unlike p11, PBMC P2RX7 mRNA levels were significantly lower than normal controls in all patients including suicide attempters, suicide non-attempters, and suicide completers. In addition, levels of S100β in PFC did not differ between suicide completers and non-suicide controls. These results suggest that PBMC p11 mRNA levels may be a potential adjunctive biomarker for the assessment of suicide risk in mental disorders and warrants a larger translational study to determine its clinical utility.
authors.affiliation: Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Lezhang@USUHS.mil
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Tung-Ping
authors.initials: TP
authors.lastname: Su
authors.forename: Kwang
authors.initials: K
authors.lastname: Choi
authors.forename: Webster
authors.initials: W
authors.lastname: Maree
authors.forename: Cheng-Ta
authors.initials: CT
authors.lastname: Li
authors.forename: Ming-Yi
authors.initials: MY
authors.lastname: Chung
authors.forename: Ying-Sheue
authors.initials: YS
authors.lastname: Chen
authors.forename: Ya-Mei
authors.initials: YM
authors.lastname: Bai
authors.forename: Yuan-Hwa
authors.initials: YH
authors.lastname: Chou
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Barker
authors.forename: James E
authors.initials: JE
authors.lastname: Barrett
authors.forename: Xiao Xia
authors.initials: XX
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.forename: David M
authors.initials: DM
authors.lastname: Benedek
authors.forename: Robert
authors.initials: R
authors.lastname: Ursano
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D017306:Annexin A2 / Q000235:genetics* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003863:Depression / Q000235:genetics* / Q000473:pathology / Q000523:psychology*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D008297:Male; D046228:Microarray Analysis / Q000379:methods; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger / Q000378:metabolism; D058486:Receptors, Purinergic P2X7 / Q000235:genetics / Q000378:metabolism; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000235:genetics* / Q000378:metabolism*; D013405:Suicide; D000099248:S100 Calcium Binding Protein A10
chemical_list: D017306:Annexin A2; D015415:Biomarkers; D009414:Nerve Growth Factors; D012333:RNA, Messenger; D058486:Receptors, Purinergic P2X7; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D000099248:S100 Calcium Binding Protein A10; C546468:P2RX7 protein, human