title: [Primary study of resting state functional magnetic resonance imaging in early onset schizophrenia using ReHo].
abstract: OBJECTIVE
  To explore the regional homogeneity of resting state brain activity in early onset schizophrenia using functional magnetic resonance imaging.
  
  
  METHODS
  Schizophrenia or schizophreniform disorder was diagnosed according to DSM-IV-TR (diagnostic and statistical manual of mental disorders, fourth edition, text revision). A total of 18 adolescents with early-onset schizophrenia (EOS; onset of psychotic symptoms by age 18) and 18 age- and gender-matched healthy volunteers were tested in a resting-state fMRI scan. Regional homogeneity approach was used to analyze the functional imaging data,and statistical parametric mapping 5 (SPM5)was used to perform t-test in ReHo maps between the patients and controls.
  
  
  RESULTS
  In comparison with the controls, the early-onset patients showed significantly decreased regional homogeneity in bilateral medial prefrontal cortex(P<0.001,uncorrected; voxel>20), but no brain regions showed significantly increased regional homogeneity in the patients.
  
  
  CONCLUSIONS
  Regional homogeneity of resting state brain activities in EOS was decreased in bilateral medial prefrontal cortex. These abnormal changes may be involved in the psychopathology of schizophrenia.
authors.affiliation: Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Shao'ai
authors.initials: S
authors.lastname: Jiang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liao
authors.forename: Weiqing
authors.initials: W
authors.lastname: Liu
authors.forename: Changlian
authors.initials: C
authors.lastname: Tan
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chen
authors.forename: Jinsong
authors.initials: J
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult