title: Off-label use of rhBMP-2 for reconstruction of critical-sized mandibular defects.
abstract: Techniques for reconstructing segmental defects of the mandible have traditionally relied upon autogenous tissue transfer. Tissue engineering has brought about the promise of de novo bone formation and the possibility of reconstruction of these defects without the drawbacks of traditional techniques. Bone morphogenic proteins (BMP) have presented themselves as the most promising in this field. We present three cases where reconstruction of critical-sized mandibular defects was attempted using recombinant human BMP-2.
authors.affiliation: Department of Dentistry, Albert Einstein College of Medicine, Bronx, NY, USA. aglied@montefiore.org
authors.forename: Allen N
authors.initials: AN
authors.lastname: Glied
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kraut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000601:surgery; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001860:Bone Plates; D016025:Bone Transplantation; D003094:Collagen; D004337:Drug Carriers; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery*; D008339:Mandibular Neoplasms / Q000601:surgery; D010012:Osteogenesis / Q000187:drug effects; D010019:Osteomyelitis / Q000601:surgery; D011994:Recombinant Proteins / Q000627:therapeutic use*; D019651:Plastic Surgery Procedures / Q000379:methods*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen