Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.
Chinese herbs have been and still are widely used as important remedies in Oriental medicine. Over the recent years, a variety of biologically active constituents have been isolated from these sources and confirmed to have multifunctional activity in experimental studies. Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares certain biological properties. Recently, honokiol and magnolol have been found to have anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties in preclinical models, without appreciable toxicity. These findings have increased interest in bringing honokiol and magnolol to the clinic as novel therapeutic agents in dermatology. In this review, the findings concerning the major mechanisms of action of honokiol and magnolol are described. Knowledge of the multiple activities of honokiol and magnolol can assist with the development of honokiol and magnolol derivatives and the design of clinical trials that will maximize the potential benefit of honokiol and magnolol in the patient setting for dermatologic disorders.
Shen
Jui-Lung
JL
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan. shen5300@yahoo.com.tw
Man
Kee-Ming
KM
Huang
Po-Hsun
PH
Chen
Wen-Chi
WC
Chen
Der-Cherng
DC
Cheng
Ya-Wen
YW
Liu
Po-Len
PL
Chou
Ming-Chih
MC
Chen
Yung-Hsiang
YH
D000975:Antioxidants / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D006801:Humans; D017705:Lignans / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D000498:Allyl Compounds; D010636:Phenols
D000975:Antioxidants; D001713:Biphenyl Compounds; D003879:Dermatologic Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols