title: Phage display selection of miniprotein binders of the Estrogen Receptor.
abstract: Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.
authors.affiliation: Chemical Genomics Centre of the Max Planck Society, Otto-Hahn Strasse 15, D-44227, Dortmund, Germany.
authors.forename: Trang
authors.initials: T
authors.lastname: Phan
authors.forename: Hoang D
authors.initials: HD
authors.lastname: Nguyen
authors.forename: Hülya
authors.initials: H
authors.lastname: Göksel
authors.forename: Sabine
authors.initials: S
authors.lastname: Möcklinghoff
authors.forename: Luc
authors.initials: L
authors.lastname: Brunsveld
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D004220:Disulfides / Q000737:chemistry; D008969:Molecular Sequence Data; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011960:Receptors, Estrogen / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004220:Disulfides; D019151:Peptide Library; D010455:Peptides; D011960:Receptors, Estrogen