Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides.
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
Hillgren
J Mikael
JM
Department of Chemistry, Umeå University, Umeå, Sweden.
Dahlgren
Markus K
MK
To
Tam M
TM
Elofsson
Mikael
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D058947:Bacterial Secretion Systems / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D007659:Ketones / Q000138:chemical synthesis; D018716:Molecular Mimicry; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D058947:Bacterial Secretion Systems; D007659:Ketones; D054852:Small Molecule Libraries; D013844:Thiazoles