title: [A new form of cell death: Parthanatos].
abstract: Parthanatos is a form of cell death, which often occurs in many diseases such as stroke, Parkinson's disease, heart attack, diabetes, and ischemia reperfusion injury. In a cell, the activation of PARP-1 caused by excitotoxicity leads to Parthanatos, which is also known as PARP-1-dependent cell death. There are multiple cell signaling pathways involved in the process of Parthanatos, which have not been fully understood. The main focus of this article is underlying molecular mechanisms of Parthanatos.
authors.affiliation: Laboratory of Development Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China. wanglianbang1984@163.com
authors.forename: Lian-Bang
authors.initials: LB
authors.lastname: Wang
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Zhang
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Shan
mesh_terms: D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D048909:Diabetes Complications / Q000473:pathology; D006801:Humans; D010300:Parkinson Disease / Q000473:pathology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D015427:Reperfusion Injury / Q000473:pathology*; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology*; D020521:Stroke / Q000473:pathology
chemical_list: D011065:Poly(ADP-ribose) Polymerases