Comparison of plasma clearance of iohexol and urinary clearance of inulin for measurement of GFR in children.
BACKGROUND
Very few studies have been published that compare plasma clearance of iohexol (Cio) with renal clearance of inulin (Cin).


METHODS
Diagnostic test study.


METHODS
60 children aged 11.6 ± 4.5 years with different kidney disorders were investigated.


METHODS
Plasma Cio calculated from the slope and a single point.


METHODS
Renal Cin with continuous infusion during water diuresis. Results were compared with the correlation coefficients, bias and precision, accuracy percentage, root mean square error, and intraclass correlation.


METHODS
Measured creatinine clearance and estimated glomerular filtration rate based on serum creatinine level and height.


RESULTS
Mean Cin was 70.7 ± 41.3 (SD) mL/min/1.73 m². Mean differences between Cio and Cin were 2.65 and 2.00 mL/min/1.73 m² for the slope and single-point methods, respectively. Precision was ±16 mL/min/1.73 m² and intraclass correlation was 0.92 in both methods. Proportions of Cio within 30% of Cin were 83.3% and 86.7% for the slope and single-point methods, respectively.


CONCLUSIONS
A limited number of patients; no adults were studied.


CONCLUSIONS
Plasma Cio shows good agreement with renal Cin.
Berg
Ulla B
UB
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. ulla.berg@ki.se
Bäck
Rune
R
Celsi
Gianni
G
Halling
Stella Edström
SE
Homberg
Inger
I
Krmar
Rafael T
RT
Monemi
Kajsa Åsling
KÅ
Oborn
Helena
H
Herthelius
Maria
M
D002648:Child; D003287:Contrast Media / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000493:pharmacokinetics* / Q000652:urine; D007472:Iohexol / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000503:physiopathology
D003287:Contrast Media; D007472:Iohexol; D007444:Inulin; D003404:Creatinine