Pharmacodynamic action of a commercial preparation of the mushroom Coprinus comatus in rats.
The pharmacodynamic effect of a 7-day oral treatment with a suspension of Coprinus comatus at doses of 0.835 and 1.670 g/kg in rats was studied. Changes in body weight, bile secretion and hypoglycaemic action were examined together with antipyretic activity and paw oedema tests. Such treatments resulted in a significantly lower increase in the body weight of tested animals (15.73 ± 8.36 g/rat in the untreated group, 8.44 ± 8.23 g/rat (p < 0.05) and 3.18 ± 7.93 g/rat (p < 0.05), for C. comatus 0.835 and 1.67 g/kg, respectively). Hypoglycaemic action was evident only in the glucose load test (6.79 ± 0.61 to 9.70 ± 1.16 (p < 0.05) in the untreated group and 6.47 ± 0.35 to 7.27 ± 0.76 for C. comatus 1.67 g/kg). Histological examination of pancreas cross-sections suggested certain protective functions of the mushroom suspension in alloxan poisoning. In the antipyretic test, a significantly lower increase in body temperature was observed in the mushroom-pretreated rats. In the paw oedema test, no decrease in oedema induced by formalin injection was observed following treatment with C. comatus.
Sabo
A
A
Department of Pharmacology, Toxicology and Clinical Pharmacology, Medical Faculty of Novi Sad, Serbia.
Stilinovic
N
N
Vukmirovic
S
S
Bukumiric
Z
Z
Capo
I
I
Jakovljevic
V
V
D000496:Alloxan / Q000506:poisoning; D000818:Animals; D058633:Antipyretics / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D001786:Blood Glucose; D001835:Body Weight; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D003302:Coprinus / Q000737:chemistry*; D004487:Edema / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D058633:Antipyretics; D001786:Blood Glucose; D002756:Cholagogues and Choleretics; D007004:Hypoglycemic Agents; D000496:Alloxan