title: Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence.
abstract: We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.
authors.affiliation: Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
authors.forename: Anass
authors.initials: A
authors.lastname: Znabet
authors.forename: Job
authors.initials: J
authors.lastname: Zonneveld
authors.forename: Elwin
authors.initials: E
authors.lastname: Janssen
authors.forename: Frans J J
authors.initials: FJ
authors.lastname: De Kanter
authors.forename: Madeleine
authors.initials: M
authors.lastname: Helliwell
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Turner
authors.forename: Eelco
authors.initials: E
authors.lastname: Ruijter
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry*; D001234:Aspergillus niger / Q000201:enzymology; D055162:Biocatalysis; D003500:Cyclization; D008995:Monoamine Oxidase / Q000378:metabolism; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000470:Alkaloids; D008995:Monoamine Oxidase