The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms.
Hormonally active vitamin D3, 1,25-(OH)2D3, is believed to have a role in the prevention of cancer formation and in limiting the aggressiveness of cancers that do arise. Therefore,much interest is presently being focused on 1,25-(OH)2D3 and its analogues as potential treatments for various cancers including melanoma. This article discusses the evidence in favour of a role for 1,25-(OH)2D3 in protection against the progression of melanocytic lesions and also summarizes the mechanisms by which 1,25-(OH)2D3 may act to protect against melanoma development and progression.
Pinczewski
Joel
J
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Slominski
Andrzej
A
D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D014807:Vitamin D / Q000096:biosynthesis / Q000502:physiology*
D014807:Vitamin D