title: Drug eluting stents versus bare metal stents in the treatment of saphenous vein graft disease: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Treatment of saphenous vein graft (SVG) disease is still a matter of debate given the uncertainty of the available conflicting data. Our aim was to assess, by means of a meta-analytic approach, the risk/benefit profile of drug eluting stents (DES) versus bare metal stents (BMS) in the treatment of SVG disease.
  
  
  RESULTS
  A search of relevant studies in several databases was performed. The endpoints of interest such as: major adverse events (MAE) (the combination of overall death and non-fatal myocardial infarction [AMI]), target vessel revascularisation (TVR), and target lesion revascularisation (TLR) have been calculated in-hospital and at the longest follow-up. Single endpoints and the rate of stent thrombosis (ST) were also assessed. Three randomised controlled trials and 15 registry studies were appraised, totalling 3,294 patients. During hospitalisation, there was no difference in the risk of MAE, overall death, AMI and TVR. No data were available to calculate the TLR rate. At a mean follow-up of 19.8 months, no significant differences were found in the risk of MAE and AMI. BMS were associated with a trend towards a higher risk of overall death (OR 1.32 [1,00-1.74], p=0.05, number needed to treat [NNT]=55). DES showed superiority in terms of TVR (OR 1.86 [1.33-2.61], p=0.0003, NNT=16), and TLR (OR 1.77 [1.27-2.48], p<0.0001, NNT=25). According to pre-specified subgroup analyses, these effects seem less evident at the long-term follow-up. DES were not associated with an increased risk of ST.
  
  
  CONCLUSIONS
  Use of DES in SVG substantially reduces both TVR and TLR. These data also demonstrate that using DES in SVG is safe and contradict previous reports of potential risks.
authors.affiliation: Department of Interventional Cardiology, Istituto clinico S. Ambrogio, Milan, Italy. luctes@gmail.com
authors.forename: Luca
authors.initials: L
authors.lastname: Testa
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Agostoni
authors.forename: Paul
authors.initials: P
authors.lastname: Vermeersch
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Biondi-Zoccai
authors.forename: William
authors.initials: W
authors.lastname: Van Gaal
authors.forename: Ravinay
authors.initials: R
authors.lastname: Bhindi
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Brilakis
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Latini
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Laudisa
authors.forename: Samuele
authors.initials: S
authors.lastname: Pizzocri
authors.forename: Stefania
authors.initials: S
authors.lastname: Lanotte
authors.forename: Nedy
authors.initials: N
authors.lastname: Brambilla
authors.forename: Adrian
authors.initials: A
authors.lastname: Banning
authors.forename: Francesco
authors.initials: F
authors.lastname: Bedogni
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D054855:Drug-Eluting Stents; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000628:therapy*; D006801:Humans; D012501:Saphenous Vein / Q000637:transplantation*; D015607:Stents