title: Symptom trajectories in posttreatment cancer survivors.
abstract: BACKGROUND
  Cancer survivorship following cancer treatment is uncertain as physical and psychological sequelae related to the disease or its treatment may persist. However, little is known about the experience of symptoms after treatment.
  
  
  OBJECTIVE
  The purposes of this study were to (1) examine postchemotherapy (post-CTX) symptom trajectories in cancer survivors and (2) determine whether demographic characteristics predicted symptom trajectories.
  
  
  METHODS
  One hundred patients who recently completed CTX for lung cancer, colorectal cancer, or lymphoma rated symptoms on an electronic patient care monitor system prior to ambulatory care visits. Latent growth curve analyses were conducted to examine the trajectories of pain, fatigue, sleep disturbance, distress, and depression for 16 months after initial CTX.
  
  
  RESULTS
  Symptoms were present at the first follow-up visit following CTX (P < .0001) and persisted over 16 months. The depression trajectory was predicted by sex: males showed a convex curvilinear growth trajectory, whereas females showed a concave trajectory (P < .05). Higher distress was predicted by younger age (P < .05).
  
  
  CONCLUSIONS
  Psychological and physical symptoms persisted over the 16-month period following CTX for the entire sample. Sex differences in coping could partially explain the different trajectories of growth for depression, but further studies are warranted. Younger patients may be more vulnerable for distress during this posttreatment phase.
  
  
  CONCLUSIONS
  The posttreatment surveillance plan for cancer survivors should include a comprehensive assessment of psychological and physical symptoms. Persistence of symptoms can be expected in some patients, and supportive interventions should be tailored according to symptom reports.
authors.affiliation: Billings Clinic Cancer Center, Billings, Montana, USA. jbrant@billingsclinic.org
authors.forename: Jeannine M
authors.initials: JM
authors.lastname: Brant
authors.forename: Susan
authors.initials: S
authors.lastname: Beck
authors.forename: William N
authors.initials: WN
authors.lastname: Dudley
authors.forename: Patrick
authors.initials: P
authors.lastname: Cobb
authors.forename: Ginette
authors.initials: G
authors.lastname: Pepper
authors.forename: Christine
authors.initials: C
authors.lastname: Miaskowski
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000523:psychology; D015897:Comorbidity; D005221:Fatigue / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000523:psychology; D008223:Lymphoma / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology; D017741:Survivors / Q000523:psychology / Q000706:statistics & numerical data*; D014481:United States