[Expression and significance of STAT3 and VEGF with MVD in the nasal polyps].
OBJECTIVE
To investigate microvessel density (MVD) and expressions of phosphor-STAT3 and vascular endothelial growth factor (VEGF) in nasal polyps, to explore their pathogenetic correlations.


METHODS
All selected cases were measured up the standard of enrollment. Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal construction. p-STAT3,VEGF and MVD in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry (sp) method.


RESULTS
In nasal polyp tissues, The positive rates of p-STAT3 and VEGF expression were 60% and 70% respectively, all were significantly higher in nasal polyps than in control inferior turbinates (P < 0.01). MVD was significantly higher in nasal polyps than in control inferior turbinates (22.78 +/- 7.89 vs 7.12 +/- 2.84, P < 0.01). p-STAT3 expression was positively correlated with VEGF expression and MVD.


CONCLUSIONS
p-STAT3, VEGF and MVD were overexpressed in the tissues of nasal polyps, and p-STAT3 expression was positively correlated with VEGF expression and MVD; p-STAT3 was positively correlated with the neovascularization of nasal polyps, The inhibition of STAT3 pathway may inhibit the neovascularization, and then inhibit the formation and recurrence of the nasal polyps.
Cao
Qingsong
Q
Department of Otorhinolaryngology, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. yyzm333@163.com
Zhang
Tao
T
Jiang
Lixin
L
Wang
Lihua
L
Luo
Sijin
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult
D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A