title: Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity.
abstract: Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data. Of the isolates obtained, 1-isomangostin and garcinone E were found to be active constituents in the anticomplement assay used.
authors.affiliation: Immune Modulators Research Center, Korea Research Institute of Bioscience and Biotechnology, 685-1 Ochangeup, Cheongwongun, ChungBuk 363-883, South Korea.
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Quan
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D051056:Complement Inactivating Agents / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry*; D015394:Molecular Structure; D014966:Xanthenes / Q000737:chemistry* / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C554678:1-isomangostin; D051056:Complement Inactivating Agents; D014966:Xanthenes; D044004:Xanthones; C470472:garcinone E; C009689:xanthone