title: AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings.
abstract: AIDS&#x2010;associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource&#x2010;limited settings. Itraconazole poorly penetrates the central nervous system, whereas fluconazole has poor activity against P. marneffei. We prospectively report management of 1 patient and retrospectively review 7 coinfection cases from Vietnam.
authors.affiliation: Wellcome Trust Major Overseas Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. thuyl@oucru.org
authors.forename: Thuy
authors.initials: T
authors.lastname: Le
authors.forename: Tran Thi
authors.initials: TT
authors.lastname: Hong Chau
authors.forename: Ngo Thi
authors.initials: NT
authors.lastname: Kim Cuc
authors.forename: Pham
authors.initials: P
authors.lastname: Si Lam
authors.forename: Tran Phu
authors.initials: TP
authors.lastname: Manh Sieu
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Shikuma
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Day
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000302:isolation & purification*; D003906:Developing Countries; D003937:Diagnosis, Differential; D015725:Fluconazole / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D010407:Penicillium / Q000187:drug effects / Q000302:isolation & purification*; D011446:Prospective Studies; D012189:Retrospective Studies; D014744:Vietnam
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole