Palladium-catalyzed decarboxylative couplings of 2-(2-azaaryl)acetates with aryl halides and triflates.
Pd-catalyzed decarboxylative cross-couplings of 2-(2-azaaryl)acetates with aryl halides and triflates have been discovered. This reaction is potentially useful for the synthesis of some functionalized pyridines, quinolines, pyrazines, benzoxazoles, and benzothiazoles. Theoretical analysis shows that the nitrogen atom at the 2-position of the heteroaromatics directly coordinates to Pd(II) in the decarboxylation transition state.
Shang
Rui
R
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Yang
Zhi-Wei
ZW
Wang
Yan
Y
Zhang
Song-Lin
SL
Liu
Lei
L
D000085:Acetates / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000085:Acetates; D002264:Carboxylic Acids; D006219:Halogens; D010165:Palladium