title: Functional recovery following intracoronary infusion of autologous mononuclear bone marrow cells in patients with chronic anterior myocardial infarction and severely depressed ventricular function.
abstract: OBJECTIVE
  Studies have shown that intracoronary infusion of mononuclear bone marrow cells improves ventricular function in patients with acute myocardial infarction. However, less information is available about the use of this therapy during the chronic phase of a myocardial infarction. This study involved an analysis of the clinical, echocardiographic and angiographic changes observed in 19 patients with a revascularized chronic anterior myocardial infarction and depressed ventricular function who were treated by cell therapy.
  
  
  METHODS
  A series of patients were monitored during treatment and 6 months and 1 year after treatment. Autologous bone marrow was obtained by needle aspiration of the iliac crest and mononuclear cells were isolated by density-gradient centrifugation. An in vitro biological study of a sample of the infused cells was performed using fluorocytometry, phenotype marking and an analysis of the chemotactic properties of the cells.
  
  
  RESULTS
  Six months and 1 year after cell therapy, a modest improvement was observed in clinical status and ventricular function, which was most pronounced in the group of patients who responded. Characteristically, these patients were revascularized close to the time of cell therapy. There was an inverse relationship between functional recovery and biological parameters that reflected a state conducive to cell migration.
  
  
  CONCLUSIONS
  The intracoronary infusion of mononuclear bone marrow cells into patients with chronic anterior myocardial infarction appeared to result in a modest clinical and functional improvement after 6 months which was sustained up to 1 year after treatment.
authors.affiliation: Servicios de Cardiología y Hematología, Unidad de Terapia Celular, Hospital Universitario Reina Sofía, Córdoba, España. grupocorpal@grupocorpal.com
authors.forename: José
authors.initials: J
authors.lastname: Suárez de Lezo
authors.forename: Concepción
authors.initials: C
authors.lastname: Herrera
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Romero
authors.forename: Manuel
authors.initials: M
authors.lastname: Pan
authors.forename: Rosario
authors.initials: R
authors.lastname: Jiménez
authors.forename: Dolores
authors.initials: D
authors.lastname: Carmona
authors.forename: José M
authors.initials: JM
authors.lastname: Segura
authors.forename: Sonia
authors.initials: S
authors.lastname: Nogueras
authors.forename: Dolores
authors.initials: D
authors.lastname: Mesa
authors.forename: Javier
authors.initials: J
authors.lastname: Suárez de Lezo
authors.forename: Djordje
authors.initials: D
authors.lastname: Pavlovic
authors.forename: Soledad
authors.initials: S
authors.lastname: Ojeda
authors.forename: Antonio
authors.initials: A
authors.lastname: Torres
mesh_terms: D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods*; D002465:Cell Movement; D002908:Chronic Disease; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000502:physiology / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000628:therapy; D006801:Humans; D019044:Image Cytometry; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D020127:Recovery of Function; D013318:Stroke Volume / Q000502:physiology; D014463:Ultrasonography; D016276:Ventricular Function