title: Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies.
abstract: Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented.
authors.affiliation: Department of Chemistry, Imperial College London, London, UK SW7 2AZ.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Martinelli
authors.forename: Beeta
authors.initials: B
authors.lastname: Balali-Mood
authors.forename: Rachael
authors.initials: R
authors.lastname: Panizzo
authors.forename: Mark F
authors.initials: MF
authors.lastname: Lythgoe
authors.forename: Andrew J P
authors.initials: AJ
authors.lastname: White
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ferretti
authors.forename: Joachim H G
authors.initials: JH
authors.lastname: Steinke
authors.forename: Ramon
authors.initials: R
authors.lastname: Vilar
mesh_terms: D000577:Amides / Q000737:chemistry*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D018360:Crystallography, X-Ray; D005063:Europium / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry; D051381:Rats; D013057:Spectrum Analysis
chemical_list: D000577:Amides; D003287:Contrast Media; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D005063:Europium; D005682:Gadolinium