Karyopyknotic cytoplasmic inclusions in neutrophils.
Karyopyknotic cytoplasmic inclusions in neutrophils (KPCI) have been previously called "Howell-Jolly" like inclusions and identified in immunosuppressed patients with human immunodeficiency virus (HIV) and in patients with various malignancies who have undergone chemotherapy. Attempts to characterize these inclusions have included the Grocott's methenamine silver (GMS), periodic acid Schiff (PAS), Gram, and Feulgen stains. Previous authors have concluded that these inclusions are of deoxyribonucleic acid (DNA) origin. We present a case describing an additional method to confirm this observation and to document previously undescribed curvilinear forms.
Ong
Menchu C
MC
Louisiana State University Health Sciences Center Department of Pathology, Shreveport, USA.
Veillon
Diana M
DM
Nordberg
Mary Lowery
ML
Cotelingam
James D
JD
D004908:Erythrocyte Inclusions / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*