[MMP-1 and MMP-3 gene encoding polymorphism and the risk of the development of pelvic organ prolapse and stress urinary incontinence].
OBJECTIVE
The estimation of the association between the polymorphism at position -1607/1608 of the gene promoter encoding matrix metalloproteinase type 1 (MMP- 1) and the polymorphism at position -1612/1617 of the gene promoter encoding stromelysin type 1 (MMP-3) and the risk of the occurrence of pelvic organ prolapse (POP) and stress urinary incontinence (SUI).


METHODS
347 women were included into the analysis. POP study: the study group consisted of patients with clinically significant POP (POP-Q scale: 2, 3, 4). Women with normal pelvic floor statics (POP-Q scale: 0, 1) and not reporting symptoms of urinary incontinence were included into the control group. SUI study: the study group--patients with symptoms of stress urinary incontinence, the control group--continent women with normal pelvic floor statics (POP-Q scale: 0, 1). Samples of DNA were isolated from whole blood. The type of polymorphism was detected by RFLP method.


RESULTS
Both, in the POP and the SUI study we have observed no statistically significant differences in the occurrences of MMP-1 and MMP-3 promoter polymorphisms between the study and the control groups. Also, the presence of the alleles G/GG (MMP-1) or 5A/6A (MMP-3) did not modify the risk of the POP and SUI development.


CONCLUSIONS
Polymorphism type G/GG of gene promoter encoding MMP-1 and polymorphism type 5A/6A of the gene promoter encoding MMP-3 are not associated with the risk of the development of POP and SUI.
Skorupski
Paweł
P
II Klinika Ginekologii Operacyjnej UM w Lublinie. pawskor@tlen.pl
Miotła
Paweł
P
Jankiewicz
Katarzyna
K
Rechberger
Tomasz
T
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D014550:Urinary Incontinence, Stress / Q000235:genetics*; D014596:Uterine Prolapse / Q000235:genetics*; D016387:Women's Health
D019278:Matrix Metalloproteinase 3; D020781:Matrix Metalloproteinase 1