Fluorescent nucleoside analogue displays enhanced emission upon pairing with guanine.
A fluorescent nucleobase analogue, 7-aminoquinazoline-2,4-(1H,3H)-dione, is incorporated into a DNA oligonucleotide and senses mismatched pairing by displaying G-specific fluorescence enhancement.
Xie
Yun
Y
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Maxson
Tucker
T
Tor
Yitzhak
Y
D001483:Base Sequence; D006147:Guanine / Q000737:chemistry*; D008969:Molecular Sequence Data; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000235:genetics; D055620:Optical Phenomena; D013050:Spectrometry, Fluorescence
D009705:Nucleosides; D009841:Oligonucleotides; D006147:Guanine