Thrombophilia mediates lowering cardiovascular risk factors in women with a history of preeclampsia.
OBJECTIVE
Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases.


METHODS
Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined.


RESULTS
Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function.


CONCLUSIONS
This study suggests that thrombophilia "mediates" in lowering of cardiovascular risk factors in women with a history of preeclampsia.
van der Horst
Marjolein
M
Department of Anesthesiology, VU University Medical Center, Amsterdam, The Netherlands. m.vanderhorst@vumc.nl
van Weissenbruch
Mirjam M
MM
de Vries
Johanna I
JI
D000328:Adult; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation; D009426:Netherlands / Q000453:epidemiology; D010865:Pilot Projects; D011225:Pre-Eclampsia; D011247:Pregnancy; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D012307:Risk Factors; D012867:Skin / Q000098:blood supply; D019851:Thrombophilia / Q000150:complications / Q000453:epidemiology*
D002784:Cholesterol