title: Soft tissue anaplastic large T-cell lymphoma associated with a metallic orthopedic implant: case report and review of the current literature.
abstract: On occasion, the placement of orthopedic prosthetic components or stabilization hardware leads to surgical site infections, in some cases presenting at a point in time distant from the surgical procedure. Although infectious complications are the most common etiology for surgical site pain and inflammation, malignancies can also develop around prosthetic devices and metallic implants. When encountered, such malignancies are most often sarcoma, but rarely B-cell non-Hodgkin's lymphoma has also been described. In this article, we describe what we believe to be the first published case of anaplastic large T-cell lymphoma associated with a stainless steel fixation plate that was implanted several years earlier for repair of a tibial fracture. Appropriate to this case, we review the medical literature on the association of orthopedic implants with the development of neoplasm, along with the theorized pathogenic mechanisms leading to such an association.
authors.affiliation: Internal Medicine, University of Miami-Miller School of Medicine at Florida Atlantic University, FL, USA.
authors.forename: Bharath
authors.initials: B
authors.lastname: Palraj
authors.forename: Anil
authors.initials: A
authors.lastname: Paturi
authors.forename: Ross G
authors.initials: RG
authors.lastname: Stone
authors.forename: Harold
authors.initials: H
authors.lastname: Alvarez
authors.forename: Matjaz
authors.initials: M
authors.lastname: Sebenik
authors.forename: Maria T
authors.initials: MT
authors.lastname: Perez
authors.forename: Larry M
authors.initials: LM
authors.lastname: Bush
mesh_terms: D000368:Aged; D001860:Bone Plates / Q000009:adverse effects*; D005593:Fracture Fixation, Internal; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000209:etiology; D013193:Stainless Steel; D013978:Tibial Fractures / Q000601:surgery
chemical_list: D013193:Stainless Steel