title: [Effects of ginkgolide on hemodynamics in myocardial ischemic dogs].
abstract: OBJECTIVE
  To investigate the effects of Ginkgolide on hemodynamics and myocardial oxygen metabolism in acute myocardial ischemic dogs.
  
  
  METHODS
  Acute myocardial ischemic model dogs were established by ligating left anterior descending coronary artery (LAD). Some hemodynamic parameters and cardiac oxygen consumption were observed after Ginkgolide were given to dogs through the duodenum.
  
  
  RESULTS
  Ginkgolide could increase LVSP, + dp/dt(max), LVWI, SW, CO and CBF, decrease TPVR, CVR, MVO2 and MOUR of Acute myocardial ischemic model dogs at different time points after ligation of LAD.
  
  
  CONCLUSIONS
  Ginkgolide can improve the hemodynamic conditions and oxygen metabolism of myocardial ischemic dogs.
authors.affiliation: Department of Pharmacology, Anhui Medical University, Hefei 230032, China. yinyanyan5678@126.com
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Yin
authors.forename: Xiao-fen
authors.initials: XF
authors.lastname: Min
authors.forename: Wei-zu
authors.initials: WZ
authors.lastname: Li
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides / Q000008:administration & dosage / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010101:Oxygen Consumption / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation
chemical_list: D004365:Drugs, Chinese Herbal; D046934:Ginkgolides