(-)-α-Bisabolol attenuates visceral nociception and inflammation in mice.
The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (-)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent.
Leite
Gerlânia de O
Gde O
Departamento de Química Biológica, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil.
Leite
Laura H I
LH
Sampaio
Renata de S
Rde S
Araruna
Mariana Késsia A
MK
de Menezes
Irwin Rose A
IR
da Costa
José Galberto M
JG
Campos
Adriana R
AR
D015746:Abdominal Pain / Q000139:chemically induced / Q000188:drug therapy*; D000208:Acute Disease; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D003106:Colon / Q000187:drug effects; D003520:Cyclophosphamide; D003872:Dermatitis / Q000188:drug therapy*; D004195:Disease Models, Animal; D004423:Ear; D008297:Male; D051379:Mice; D000081222:Monocyclic Sesquiterpenes; D009149:Mustard Plant; D009822:Oils, Volatile / Q000737:chemistry; D010537:Peritoneum / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010938:Plant Oils; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; D012717:Sesquiterpenes; C004497:bisabolol; D003520:Cyclophosphamide; C027793:mustard oil