title: No further increase in the incidence of esophageal adenocarcinoma in Sweden.
abstract: Since 1970, the incidence of esophageal adenocarcinoma has increased rapidly in Western populations, whereas the incidences of gastric cardia and gastric non-cardia adenocarcinoma have increased moderately and declined, respectively. The Swedish Cancer Register and Total Population Register provided opportunities for a valid update of incidence trends of these tumors including the year 2008. Joinpoint regression was used to assess any shifts in trends with calendar time. The esophageal adenocarcinoma incidence reached a peak in 2005, and then showed a decrease. During the period 2001-2008, the joinpoint regression analysis indicates a virtually stable incidence (annual percentage increase 1.1, 95% confidence interval [CI] -2.7 to 5.1). The cardia adenocarcinoma incidence has slightly decreased after 1990 (annual percentage decrease -1.0, 95% CI -1.6 to -0.3). The decreasing incidence of gastric non-cardia adenocarcinoma has continued steadily during recent years (annual percentage decrease -4.9 (95% CI -5.2 to -4.7). Thus, an encouraging break in the rising incidence of esophageal adenocarcinoma has been seen in Sweden since 2005, whereas the corresponding incidences of gastric cardia and non-cardia adenocarcinoma have been stable and decreasing, respectively.
authors.affiliation: Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Stockholm, Sweden. jesper.lagergren@ki.se
authors.forename: Jesper
authors.initials: J
authors.lastname: Lagergren
authors.forename: Fredrik
authors.initials: F
authors.lastname: Mattsson
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D002299:Cardia; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012042:Registries; D013274:Stomach Neoplasms / Q000453:epidemiology; D013548:Sweden / Q000453:epidemiology