title: Predictive factors for the detection of CIN II-III in the follow-up of women with CIN I.
abstract: OBJECTIVE
  To determine which factors may increase the risk that women diagnosed with CIN I may later develop CIN II-III.
  
  
  METHODS
  A prospective study of 174 women with a grade 1 intraepithelial lesion (CIN I) confirmed by biopsy, with a follow-up time of at least one year. The following factors were studied: age, HPV infection, HPV infection by a high-risk genotype, the HPV genotypes involved, coinfection by several HPV genotypes and duration of follow-up. These factors were correlated with later detection of CIN II-III by biopsy during follow-up. Statistical analysis was performed using SPSS.
  
  
  RESULTS
  CIN II-III was detected at the follow-up in 24 of 174 women included in the study (13.7%), in four cases by colposcopically directed biopsy and in 20 by LLETZ. Correlation of the factors studied with the incidence of CIN II-III in this group showed that the only statistically significant factors were overall HPV infection and HPV infection by genotypes 31 and 70 (Chi-square and Fisher's test, p < 0.05, respectively), while the duration of follow-up came close to statistical significance (Student's test, p = 0.052).
  
  
  CONCLUSIONS
  HPV infection and duration of follow-up are predictive factors for the detection of CIN II-III in follow-up care for women with CIN I.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital Sant Joan de Déu, University of Barcelona, Esplugues (Barcelona). edugonzalez@hsjdbcn.org
authors.forename: E
authors.initials: E
authors.lastname: Gonzalez-Bosquet
authors.forename: L
authors.initials: L
authors.lastname: Selva
authors.forename: J
authors.initials: J
authors.lastname: Sabria
authors.forename: L
authors.initials: L
authors.lastname: Pallares
authors.forename: L
authors.initials: L
authors.lastname: Almeida
authors.forename: C
authors.initials: C
authors.lastname: Muñoz-Almagro
authors.forename: J M
authors.initials: JM
authors.lastname: Lailla
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology