title: Caffeic acid effects on oxidative stress in rat hippocampus after pilocarpine-induced seizures.
abstract: The objective of the study was to evaluate the caffeic acid (CA) effects against the oxidative stress (OS) observed during seizures. Wistar rats were intraperitoneally treated with either 0.9% saline (control), CA (4 mg/kg), pilocarpine (400 mg/kg, pilocarpine group), or the association of CA (4 mg/kg) plus pilocarpine (400 mg/kg). The thiobarbituric-acid-reacting substances and the hippocampal nitrite content were significantly increased (89 and 94%, respectively) in pilocarpine group when compared with control. There were marked decreases in lipid peroxidation level (43%) and nitrite content (45%) in CA group when compared with pilocarpine group. There were no marked alterations in superoxide dismutase (SOD) and catalase (CAT) activities in pilocarpine group; however, the SOD and CAT activities were significantly increased (35 and 51%, respectively) after CA pretreatment. Our findings strongly support the hypothesis that OS was indeed generated in hippocampus. CA pretreatment can reduces the OS produced by seizures.
authors.affiliation: Laboratory of Research in Experimental Neurochemistry, Curso de Farmácia, Centro de Ciências da Saúde, Federal University of Piaui, Campus Universitário Ministro Petrônio Portella, Bairro Ininga, Teresina, PI 64049-550, Brazil.
authors.forename: Ítala Mônica
authors.initials: ÍM
authors.lastname: dos Santos Sales
authors.forename: Katia Gomes
authors.initials: KG
authors.lastname: do Nascimento
authors.forename: Chistiane Mendes
authors.initials: CM
authors.lastname: Feitosa
authors.forename: Gláucio Barros
authors.initials: GB
authors.lastname: Saldanha
authors.forename: Dejiang
authors.initials: D
authors.lastname: Feng
authors.forename: Rivelilson Mendes
authors.initials: RM
authors.lastname: de Freitas
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced* / Q000378:metabolism* / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009410:Nerve Degeneration / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D018696:Neuroprotective Agents; C040048:caffeic acid