Intradural cranial chordoma.
BACKGROUND
Intradural chordomas are rare and have been considered benign owing to the feasibility of complete resection and the display of lesser aggressive biologic behavior than typical chordomas.


METHODS
We herein reported 2 cases of intradural cranial chordoma with aggressive biologic behavior. A tumor (anti-Ki-67 monoclonal antibody [MIB-1], 13.9%) in a 59-year-old woman was strongly adherent to the brainstem and involved the basilar artery and its branches. After subtotal removal, the remnant tumor was treated with stereotactic radiotherapy. A tumor (MIB-1, 6.2%) in a 75-year-old woman repeatedly recurred even after initial gross total removal. The recurrent chordomas were treated with γ-knife radiosurgery.


CONCLUSIONS
The cases presented in this study indicate that intradural chordomas can also be aggressive such as typical chordomas. Long-term follow-ups with a large number of patients with this condition are essential for elucidating the prognosis of intradural chordomas.
Ito
Eiji
E
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Saito
Kiyoshi
K
Nagatani
Tetsuya
T
Ishiyama
Junzo
J
Terada
Koichi
K
Yoshida
Mitsuhiro
M
Wakabayashi
Toshihiko
T
D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D002817:Chordoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D004388:Dura Mater; D005260:Female; D006801:Humans; D008875:Middle Aged; D016634:Radiosurgery