Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.
Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.
Calis
Job C J
JC
Global Child Health Group, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands. job.calis@gmail.com
Phiri
Kamija S
KS
Vet
Raymond J W M
RJ
de Haan
Rob J
RJ
Munthali
Francis
F
Kraaijenhagen
Robert J
RJ
Hulshof
Paul J M
PJ
Molyneux
Malcolm E
ME
Brabin
Bernard J
BJ
Boele van Hensbroek
Michaël
M
Bates
Imelda
I
D000740:Anemia / Q000276:immunology*; D001853:Bone Marrow / Q000821:virology*; D016022:Case-Control Studies; D002675:Child, Preschool; D004920:Erythropoiesis / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny