[Adipocytokines and assay method in metabolic syndrome].
Adipocytokines, such as adiponectin, TNF-alpha, and leptin, are cytokines secreted by visceral adipocytes, and they are associated with metabolic syndrome. Adiponectin is one of the adipocytokines, and is a protein comprised of 244 amino acids. It is known as ACRP30, GBP28, and AdipoQ. Adiponectin is secreted by adipocytes, has three different isoforms, including trimers (low-molecular weight: LMW), hexamers (middle-molecular-weight: MMW), and higher-order oligomeric (high-molecular-weight: HMW) structures, and affects the biological activity. Adiponectin is a clinically relevant parameter measured routinely in subjects at risk of type 2 diabetes and metabolic syndrome. We investigated the adiponectin levels using a number of ELISA assay kits.
Abe
Akio
A
Immunochemistry Testing Department, SRL, Inc., Hachioji 192-8535, Japan. a-abe@srl.srl-inc.co.jp
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D054439:Ghrelin / Q000097:blood; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D020738:Leptin / Q000097:blood; D024821:Metabolic Syndrome / Q000175:diagnosis*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011933:Reagent Kits, Diagnostic; D052243:Resistin / Q000097:blood; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D054439:Ghrelin; C587883:HBEGF protein, human; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D011933:Reagent Kits, Diagnostic; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha