title: Synthesis and preliminary anti-HIV activities of andrographolide derivatives.
abstract: Recent studies indicated that andrographolide was a potential anti-HIV therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their anti-HIV activities were evaluated in vitro. As compared with TI, compounds 5c, 5d and 5i showed moderate inhibitory activities on the cytopathic effect with TI above 10. Among the derivatives, compound 5i was the best one with TI > 51.
authors.affiliation: Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Ge
authors.forename: Wenlong
authors.initials: W
authors.lastname: Huang
authors.forename: Huibin
authors.initials: H
authors.lastname: Zhang
authors.forename: Hai
authors.initials: H
authors.lastname: Qian
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yongtang
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; C030419:andrographolide