Nanotechnology and HIV: potential applications for treatment and prevention.
HIV/AIDS is a global pandemic and is the leading infectious cause of death among adults. Although antiretroviral (ARV) therapy has dramatically improved the quality of life and increased the life expectancy of those infected with HIV, life-long suppressive treatment is required and a cure for HIV infection remains elusive; frequency of dosing and drug toxicity as well as the development of viral resistance pose additional limitations. Furthermore, preventative measures such as a vaccine or microbicide are urgently needed to curb the rate of new infections. The capabilities inherent to nanotechnology hold much potential for impact in the field of HIV treatment and prevention. This article reviews the potential for the multidisciplinary field of nanotechnology to advance the fields of HIV treatment and prevention.
Kim
Peter S
PS
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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Sarah W
SW
D016915:AIDS Vaccines / Q000008:administration & dosage; D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage; D016503:Drug Delivery Systems; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D049329:Nanostructures / Q000627:therapeutic use*; D036103:Nanotechnology
D016915:AIDS Vaccines; D019380:Anti-HIV Agents