title: WT1 expression correlates with angiogenesis in endometrial cancer tissue.
abstract: BACKGROUND
  No direct comparison has been made of the relationship between the expression of Wilms' tumor gene WT1 within tumor cells and angiogenesis in vivo.
  
  
  METHODS
  A series of 70 endometrial cancer patients who had undergone a curative resection was studied by immunohistochemistry to determine the correlation between WT1 expression, angiogenesis (proliferation of endothelial cell adhesion molecule-1, PECAM-1/CD31) and angiogenic growth factor (vascular endothelial growth factor, VEGF).
  
  
  RESULTS
  A strong association was found between WT1 expression score and mean vascular density (p<0.001, n=70, ϱ=0.568). Immunohistochemistry of serial sections revealed that WT1 and VEGF were co-expressed in the same area of endometrial cancer tissue.
  
  
  CONCLUSIONS
  Tumor-produced WT1, which may regulate the expression of VEGF, is found to be associated with induction of angiogenesis in endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640 Japan. satoshi.dohi1018@gmail.com
authors.forename: Satoshi
authors.initials: S
authors.lastname: Dohi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ohno
authors.forename: Satoru
authors.initials: S
authors.lastname: Kyo
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Soma
authors.forename: Haruo
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Masaki
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000098:blood supply* / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D025721:WT1 Proteins / Q000378:metabolism*
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D025721:WT1 Proteins