title: A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma.
abstract: Central neurocytomas are low-grade tumors of neuronal origin located in the lateral ventricle that present predominantly with raised intracranial pressure. In this retrospective study, we investigated the clinical, radiological, histopathological and immunohistochemical features of eight patients (seven males and one female; age range 16-61 years; mean=35.1 years) with neurocytoma. Raised intracranial pressure was the most common presenting feature. In addition, one patient presented with marked visual deterioration and one presented with a visual field defect. All lesions were located in the lateral ventricle (right lateral ventricle: four patients, left lateral ventricle: three patients, both ventricles: one patients). Radiology showed marked intratumoral calcification in two patients. Total microsurgical excision was achieved in seven patients. Histopathology showed sheets of monotonously small-to-medium-sized neoplastic cells with uniform round-to-oval nuclei and inconspicuous nucleoli. Immunohistochemistry was positive for synaptophysin and neuron-specific enolase (NSE) in all tumors, and glial fibrillary acidic protein was focally positive in two patients. One patient had lipomatous differentiation within the tumor. No recurrence was noted in any of our patients until the last follow-up; however, there were two deaths in our series.
authors.affiliation: Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India. sushilapath@yahoo.com
authors.forename: Sushila
authors.initials: S
authors.lastname: Jaiswal
authors.forename: Mukul
authors.initials: M
authors.lastname: Vij
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rajput
authors.forename: Anant
authors.initials: A
authors.lastname: Mehrotra
authors.forename: Awadhesh Kumar
authors.initials: AK
authors.lastname: Jaiswal
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Narendra
authors.initials: N
authors.lastname: Krishnani
mesh_terms: D000293:Adolescent; D000328:Adult; D002114:Calcinosis / Q000209:etiology; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019586:Intracranial Hypertension / Q000209:etiology; D020547:Lateral Ventricles / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018306:Neurocytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000096:biosynthesis; D016708:Synaptophysin / Q000096:biosynthesis; D055815:Young Adult
chemical_list: D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase