title: Neoaortic valve and root complex evolution after Ross operation in infants, children, and adolescents.
abstract: BACKGROUND
  The Ross operation in children and adolescents offers many potential advantages. Concerns have been raised about the long-term development of the neoaortic complex and the risk of dilation.
  
  
  METHODS
  Retrospective analysis of prospectively collected follow-up data in a population of patients who underwent Ross operations when they were younger than 18 years old was conducted. Echocardiographic and clinical data, including survival, need for reoperations, and quality of life, were analyzed in 95 patients for a median follow-up of 84 months.
  
  
  RESULTS
  The neoaortic root and sinotubular junction demonstrated dilation that exceeded somatic growth. The neoaortic valve grew in a manner that reflected somatic proportions. Freedom from moderate neoaortic root dilation was 100% at 5 years and 77% after 10 years. Freedom from moderate neoaortic valve insufficiency was 86% at 5 years after the Ross procedure and 63% after 10 years. The use of a proximal anastomosis running suture (p = 0.005) and the degree of neoaortic valve insufficiency (p = 0.032) at discharge were independently associated with the degree of neoaortic valve insufficiency at follow-up. Freedom from neoaortic reintervention was 96% at the 5-year follow-up and 80% at the 10-year follow-up. Predictors of neoaortic reintervention were the use of an operative technique other than aortic root replacement (p = 0.002) and the degree of neoaortic valve insufficiency at discharge (p = 0.005).
  
  
  CONCLUSIONS
  The Ross operation remains a viable option for children and adolescents with severe aortic valve disease; neoaortic complex dilation occurs but is not directly responsible for neoaortic valve insufficiency, which is the main cause for reoperation.
authors.affiliation: Department of Cardiac Surgery, IRCCS Policlinico S. Donato, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.forename: Alessandro
authors.initials: A
authors.lastname: Varrica
authors.forename: Angela
authors.initials: A
authors.lastname: Satriano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giamberti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pomè
authors.forename: Raul
authors.initials: R
authors.lastname: Abella
authors.forename: Mario
authors.initials: M
authors.lastname: Carminati
authors.forename: Concetta
authors.initials: C
authors.lastname: Carlucci
authors.forename: Marco
authors.initials: M
authors.lastname: Ranucci
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000473:pathology / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000209:etiology* / Q000601:surgery; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004108:Dilatation, Pathologic; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D011664:Pulmonary Valve / Q000637:transplantation; D012086:Reoperation; D012189:Retrospective Studies; D055815:Young Adult