Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response.
The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.
Fendt
Markus
M
Novartis Institutes of BioMedical Research, Neuropsychiatry, GPCR Expertise Program, Basel, Switzerland. markus.fendt@novartis.com
Buchi
Mélanie
M
Bürki
Hugo
H
Imobersteg
Stefan
S
Ricoux
Bérangère
B
Suply
Thomas
T
Sailer
Andreas W
AW
D000161:Acoustic Stimulation; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D046353:Immobility Response, Tonic / Q000187:drug effects / Q000502:physiology; D057967:Infusions, Intraventricular; D007266:Inhibition, Psychological; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013216:Reflex, Startle / Q000187:drug effects / Q000235:genetics* / Q000502:physiology
C515062:NPSR1 protein, mouse; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; C539972:neuropeptide S, mouse; D003042:Cocaine