title: Lymphangiosarcoma complicating extensive congenital mixed vascular malformations.
abstract: Pediatric hepatic angiosarcoma is a very rare malignant vascular tumor. A few cases have shown pediatric hepatic angiosarcoma occurring on a background of preexisting vascular lesions. We report the case of a newborn girl who presented extensive limbs and upper trunk cutaneous mixed vascular malformations at birth. These malformations were associated with thrombocytopenia. Cutaneous biopsies revealed complex vascular malformations with a significant lymphatic component. Compressive body suit therapy led to regression of the limbs' cutaneous vascular malformations. At the age of 9 months, the patient presented multiple heterogeneous hepatosplenic nodules. Aggressive treatment with prednisone, vincristine, and hepatosplenic embolizations resulted in initial improvement of the hepatosplenic lesions for few months, followed by an increase of the lesions with failure of response to treatment despite adding alpha-interferon-2b to treatment. The patient died at the age of 19 months. The autopsy's pathological examination revealed a hepatic-based angiosarcoma with plurimetastatic dissemination to the spleen, lungs, peritoneum, pleura, mesenteric linings as well as the serosa of the stomach and small intestine. Multiple cutaneous and visceral complex capillaro-lymphatico-venous malformations were also identified. We hypothesize that these multiple extensive mixed vascular malformations were associated with chronic lymphedema which probably predisposed to the development of the angiosarcoma in our patient.
authors.affiliation: Division of Dermatology, CHU Sainte Justine, University of Montreal, Montreal, Quebec, Canada. roladhaybi@yahoo.com
authors.forename: Rola
authors.initials: R
authors.lastname: Al Dhaybi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Agoumi
authors.forename: Julie
authors.initials: J
authors.lastname: Powell
authors.forename: Josée
authors.initials: J
authors.lastname: Dubois
authors.forename: Victor
authors.initials: V
authors.lastname: Kokta
mesh_terms: D001344:Autopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008204:Lymphangiosarcoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D017445:Skin Diseases, Vascular / Q000150:complications / Q000151:congenital / Q000188:drug therapy; D054079:Vascular Malformations / Q000150:complications* / Q000188:drug therapy / Q000473:pathology