title: Spiroborate esters in the borane-mediated asymmetric synthesis of pyridyl and related heterocyclic alcohols.
abstract: The effectiveness of several spiroborate ester catalysts was investigated in the asymmetric borane reduction of 2-, 3-, 4-acetylpyridines under different reaction conditions. Highly enantiomerically enriched 1-(2-, 3- and 4-pyridyl)ethanols and 1-(heterocyclic)ethanols were obtained using 1 to 10% catalytic loads of the spiroborate 5 derived from diphenylprolinol and ethylene glycol.
authors.affiliation: Department of Chemistry, University of Puerto Rico-Humacao, CUH Station, Humacao, Puerto Rico 00791, USA.
authors.forename: Viatcheslav
authors.initials: V
authors.lastname: Stepanenko
authors.forename: Melvin
authors.initials: M
authors.lastname: De Jesús
authors.forename: Wildeliz
authors.initials: W
authors.lastname: Correa
authors.forename: Irisbel
authors.initials: I
authors.lastname: Guzmán
authors.forename: Cindybeth
authors.initials: C
authors.lastname: Vázquez
authors.forename: Lymaris
authors.initials: L
authors.lastname: Ortiz
authors.forename: Margarita
authors.initials: M
authors.lastname: Ortiz-Marciales