Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer.
In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer. The peculiar metabolism of dietary compounds of the individual microbiota complement, its overall immunostimulation and immunomodulatory activity, and eventually the production of toxins that perturb the regulation of cell growth, define the balance of positive and negative risk factors for colorectal cancer development. Moreover, shaping the composition of the human intestinal microbiota, diet has an indirect impact in determining the balance between health and disease. The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset.
Candela
Marco
M
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. marco.candela@unibo.it
Guidotti
Marco
M
Fabbri
Alessia
A
Brigidi
Patrizia
P
Franceschi
Claudio
C
Fiorentini
Carla
C
D015179:Colorectal Neoplasms / Q000382:microbiology*; D004032:Diet; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D054892:Metagenome