title: Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter.
abstract: De novo lipogenesis, the production of fats from simple precursors, is often dismissed as irrelevant to the pathobiology of obesity caused by positive energy balance due to typical high fat diets. However, emerging data implicate de novo lipogenesis in the generation of metabolic signals that alter disease risk. Exploiting this signaling pathway represents lipoexpediency. Lipoexpediency is the concept of directing fats toward benefit even in the setting of lipid overload, and represents a strategy to complement efforts aimed at improving energy balance. Optimizing lipid signals initiated by key lipogenic enzymes such as fatty acid synthase might limit morbidity in people who are unlikely to abandon the lifestyle of the sedentary gourmand.
authors.affiliation: Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
authors.forename: Irfan J
authors.initials: IJ
authors.lastname: Lodhi
authors.forename: Xiaochao
authors.initials: X
authors.lastname: Wei
authors.forename: Clay F
authors.initials: CF
authors.lastname: Semenkovich
mesh_terms: D000818:Animals; D004435:Eating / Q000235:genetics / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D050155:Lipogenesis / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D047493:PPAR alpha / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D047493:PPAR alpha