Predicting acute affective symptoms after deep brain stimulation surgery in Parkinson's disease.
The current study aimed to investigate predictive markers for acute symptoms of depression and mania following deep brain stimulation (DBS) surgery of the subthalamic nucleus for the treatment of motor symptoms in Parkinson's disease (PD). Fourteen patients with PD (7 males) were included in a prospective longitudinal study. Neuropsychological tests, psychopathology scales and tests of motor functions were administered at several time points prior to and after neurosurgery. Pre-existing psychopathological and motor symptoms predicted postoperative affective side effects of DBS surgery. As these can easily be assessed, they should be considered along with other selection criteria for DBS surgery.
Schneider
Frank
F
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. fschneider @ ukaachen.de
Reske
Martina
M
Finkelmeyer
Andreas
A
Wojtecki
Lars
L
Timmermann
Lars
L
Brosig
Timo
T
Backes
Volker
V
Amir-Manavi
Atoosa
A
Sturm
Volker
V
Habel
Ute
U
Schnitzler
Alfons
A
D000342:Affective Symptoms / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D000368:Aged; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards; D010300:Parkinson Disease / Q000523:psychology / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020531:Subthalamic Nucleus / Q000502:physiology