title: Guidelines for nomenclature assignment of Ger receptors.
abstract: Some members of the orders Bacillales and Clostridiales form dormant spores when subjected to environmental stress. These resistant spores return to normal vegetative growth upon encountering nutrients. A family of membrane-bound proteins called germination (Ger) receptors is tasked with detecting metabolites that serve as germination signals. During the characterization of tripartite Ger receptor proteins from the genera Bacillus and Clostridium, we found numerous nomenclature inconsistencies. In this work, we issued guidelines to remediate this problem. We generated a sample of sequenced Bacillus, Clostridium and related endospore-forming genera. Ger receptor proteins were recovered from these genomes by PSI-BLAST. The resulting Ger receptor protein sequences were then clustered by neighbor-joining based on sequence alignment. Inconsistencies in Ger receptor labeling were noted and new names proposed. Finally, a systematic approach for naming of new Ger receptors was designed.
authors.affiliation: School of Life Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, Las Vegas, NV 89154, USA. rossc6@unlv.nevada.edu
authors.forename: Christian A
authors.initials: CA
authors.lastname: Ross
authors.forename: Ernesto
authors.initials: E
authors.lastname: Abel-Santos
mesh_terms: D056449:Bacillales / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D003013:Clostridium / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D016000:Cluster Analysis; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013171:Spores, Bacterial / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D009626:Terminology as Topic
chemical_list: D008565:Membrane Proteins