title: A semi-automatic method for segmentation of the carotid bifurcation and bifurcation angle quantification on black blood MRA.
abstract: Quantitative information about the geometry of the carotid artery bifurcation may help in predicting the development of atherosclerosis. A geodesic active contours based segmentation method combining both gradient and intensity information was developed for semi-automatic, accurate and robust quantification of the carotid bifurcation angle in Black Blood MRA data. The segmentation method was evaluated by comparing its accuracy to inter and intra observer variability on a large dataset that has been acquired as part of a longitudinal population study which investigates the natural progression of carotid atherosclerosis. Furthermore, the method is shown to be robust to initialization differences. The bifurcation angle obtained from the segmented lumen corresponds well with the angle derived from the manual lumen segmentation, which demonstrates that the method has large potential to replace manual segmentations for extracting the carotid bifurcation angle from Black Blood MRA data.
authors.affiliation: Department of Radiology, Erasmus MC-University Medical Center Rotterdam, The Netherlands. h.tang@tudelft.nl
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
authors.forename: Robbert S
authors.initials: RS
authors.lastname: van Onkelen
authors.forename: Theo
authors.initials: T
authors.lastname: van Walsum
authors.forename: Reinhard
authors.initials: R
authors.lastname: Hameeteman
authors.forename: Michiel
authors.initials: M
authors.lastname: Schaap
authors.forename: Fufa L
authors.initials: FL
authors.lastname: Tori
authors.forename: Quirijn J A
authors.initials: QJ
authors.lastname: van den Bouwhuijsen
authors.forename: Jacqueline C M
authors.initials: JC
authors.lastname: Witteman
authors.forename: Aad
authors.initials: A
authors.lastname: van der Lugt
authors.forename: Lucas J
authors.initials: LJ
authors.lastname: van Vliet
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
mesh_terms: D000465:Algorithms; D002339:Carotid Arteries / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity