title: Predicting acute affective symptoms after deep brain stimulation surgery in Parkinson's disease.
abstract: The current study aimed to investigate predictive markers for acute symptoms of depression and mania following deep brain stimulation (DBS) surgery of the subthalamic nucleus for the treatment of motor symptoms in Parkinson's disease (PD). Fourteen patients with PD (7 males) were included in a prospective longitudinal study. Neuropsychological tests, psychopathology scales and tests of motor functions were administered at several time points prior to and after neurosurgery. Pre-existing psychopathological and motor symptoms predicted postoperative affective side effects of DBS surgery. As these can easily be assessed, they should be considered along with other selection criteria for DBS surgery.
authors.affiliation: Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. fschneider @ ukaachen.de
authors.forename: Frank
authors.initials: F
authors.lastname: Schneider
authors.forename: Martina
authors.initials: M
authors.lastname: Reske
authors.forename: Andreas
authors.initials: A
authors.lastname: Finkelmeyer
authors.forename: Lars
authors.initials: L
authors.lastname: Wojtecki
authors.forename: Lars
authors.initials: L
authors.lastname: Timmermann
authors.forename: Timo
authors.initials: T
authors.lastname: Brosig
authors.forename: Volker
authors.initials: V
authors.lastname: Backes
authors.forename: Atoosa
authors.initials: A
authors.lastname: Amir-Manavi
authors.forename: Volker
authors.initials: V
authors.lastname: Sturm
authors.forename: Ute
authors.initials: U
authors.lastname: Habel
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
mesh_terms: D000342:Affective Symptoms / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D000368:Aged; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards; D010300:Parkinson Disease / Q000523:psychology / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020531:Subthalamic Nucleus / Q000502:physiology