Trichosporon inkin Esophagitis: An Uncommon Disease in a Patient with Pulmonary Cancer.
Trichosporon species are usually opportunistic pathogens. Here, we present a case of esophagitis caused by T. inkin in a 54-year-old woman with pulmonary cancer and severe neutropenia in whom the susceptibility profile of the isolate against azoles and polyenes was verified. The patient was diagnosed with esophagitis grade I of Wilcox, presenting scattered whitish plaques and exudates in upper two-thirds of the esophageal mucosa. Antifungal therapy involving oral fluconazole (150 mg/day for 14 days) was ineffective. In vitro, the isolate showed no resistance to this azole and sensitivity to amphotericin B. Since T. inkin is of growing importance as an agent of invasive infections in immunocompromised patients, we stress that the diagnosis of esophagitis by this species should be followed by an assessment of the therapeutic sensitivity of the strain involved.
Macêdo
Danielle Patrícia Cerqueira
DP
Departamento de Micologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Nelson Chaves, s/n, Cidade Universitária, Recife, PE, 50670-420, Brazil. danielle_xande@yahoo.com.br
de Oliveira
Neiva Tinti
NT
da Silva
Vanessa Karina Alves
VK
de Almeida Farias
Aline Mary
AM
de Lima Neto
Reginaldo Gonçalves
RG
Wilheim
Ana Botler
AB
de Oliveira
Patrícia Cariolano
PC
Pedi
Nadyr
N
de Andrade
Suanni Lemos
SL
Neves
Rejane Pereira
RP
D000935:Antifungal Agents / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology; D004941:Esophagitis / Q000382:microbiology* / Q000473:pathology*; D004945:Esophagoscopy; D004947:Esophagus / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008175:Lung Neoplasms / Q000150:complications; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis* / Q000473:pathology*; D009503:Neutropenia / Q000150:complications; D011090:Polyenes / Q000494:pharmacology; D017211:Treatment Failure; D014250:Trichosporon / Q000187:drug effects / Q000302:isolation & purification*
D000935:Antifungal Agents; D001393:Azoles; D011090:Polyenes