title: Ameliorated effects of green tea extract on lead induced liver toxicity in rats.
abstract: In the present study, the effect of green tea extract (GTE) on lead induced toxicity was studied in Sprague-Dawley rats. Four groups of rats were used in the study. Lead and GTE was given orally to the rats with drinking water for 8 weeks. Lead concentration in the digested tissues of liver was detected using atomic absorption spectroscopy. The activities of glutathione-S-transferase (GST) and superoxide dismutase (SOD) were used as markers to evaluate the anti oxidant status of tissues. Lead exposure was found to attenuate the antioxidant potential of liver, which was however augmented when supplemented with green tea extract. Liver enzymes ALT, AST and ALP and serum protein determinations indicated the protective effects of green tea extract. Histopathological studies of liver revealed that supplementation of green tea extract resulted in mild degeneration and congestion of the blood vessels and an enhanced regenerative capacity.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, Alexandria University, Egypt.
authors.forename: E E
authors.initials: EE
authors.lastname: Mehana
authors.forename: Abdel Raheim M A
authors.initials: AR
authors.lastname: Meki
authors.forename: Khalid Majid
authors.initials: KM
authors.lastname: Fazili
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D028241:Camellia sinensis / Q000737:chemistry; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008111:Liver Function Tests; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D013662:Tea / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D013662:Tea; D013482:Superoxide Dismutase; D005978:Glutathione