title: Ubiquitin Drug Discovery and Diagnostics Conference - targeting E3 ligases.
abstract: The Ubiquitin Drug Discovery and Diagnostics Conference, held in Philadelphia, included topics covering the role of E3 ligases in disease. This conference report highlights selected presentations on E3-E2 ligase interactions, the SCF cyclin F ubiquitin ligase complex, and targeting HectH9 and KF-1 E3 ligases. Pharmaceutical research discussed includes E3 programs from Progenra and efforts to modulate the Parkin ligase at Elan Pharmaceuticals.
authors.affiliation: Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, CA 94080-7021, USA. jennifer.johnston@elan.com
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Johnston
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006801:Humans; D008025:Ligases / Q000378:metabolism; D051379:Mice; D058990:Molecular Targeted Therapy; D044843:SKP Cullin F-Box Protein Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013379:Substrate Specificity; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; C502830:HUWE1 protein, human; D044843:SKP Cullin F-Box Protein Ligases; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases