[A neonatal case of immunoallergic acute interstitial nephritis].
Acute interstitial nephritis accounts for about 10 % of the cases of acute renal failure. An adverse drug reaction caused by an immunoallergic mechanism is suggested when fever, skin rash, eosinophilia, and eosinophiluria are associated. The outcome is favorable after withdrawal of drug therapy in most cases. We report a case of acute interstitial nephritis induced by immunoallergic drug mechanisms, in a 3-week-old infant who presented with acute renal failure associated with eosinophilia and hepatitis and who had received cefotaxime and gentamicin. The patient's progression was favorable with normalization of renal and liver function 1 week after suspension of antibiotic drugs.
Essid
A
A
Service de réanimation pédiatrique, hôpital Raymond-Poincaré, Assistance publique-Hôpitaux de Paris, 104, boulevard Raymond-Poincaré, 92380 Garches, France. aben.essid@rpc.aphp.fr
Allani-Essid
N
N
Rubinsztajn
R
R
Estournet
B
B
Bataille
J
J
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002439:Cefotaxime / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced; D005839:Gentamicins / Q000009:adverse effects*; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002439:Cefotaxime