title: Localization of absorbers in scattering media by use of frequency-domain measurements of time-dependent photon migration.
abstract: Frequency-domain studies of time-dependent light propagation in tissuelike phantoms that contain optical heterogeneities are described. Specifically the phase shift and amplitude modulation of reemergent light were measured when illuminated by an amplitude-modulated light source. Changes in the phase angle and the extent of modulation revealed the presence of a light-absorbing object. Furthermore the magnitude and direction of these changes were sensitive to the absorber depth and the light modulation frequency in a manner that could be used to infer the location of the heterogeneity. These data suggest the feasibility of optical imaging by frequency-domain methods.
authors.forename: E M
authors.initials: EM
authors.lastname: Sevick
authors.forename: J K
authors.initials: JK
authors.lastname: Frisoli
authors.forename: C L
authors.initials: CL
authors.lastname: Burch
authors.forename: J R
authors.initials: JR
authors.lastname: Lakowicz