title: When patients report diseases that prescribers seem unaware of: discordance between patient and physician reporting of risk-related previous history in NSAID users from the CADEUS study.
abstract: Prescribers are often unaware of possibly dangerous previous medical histories (PMHs) of their patients. Data from a study of nonsteroidal anti-inflammatory drug (NSAID) users served to identify factors associated with this lack of awareness. In this study, we analyzed the factors that may have led prescribers to report the absence of some PMHs that the patients reported as being present. Of 26,618 patients prescribed an NSAID, 469 (1.7%) reported a PMH of unstable angina, 648 (2.4%) reported heart failure, 2,244 (8.4%) reported gastric or duodenal ulcer, 489 (1.8%) reported upper gastrointestinal tract bleeding (UGIB), 5,343 (20.0%) reported gastroesophageal reflux disease (GERD), and 7,832 (29.4%) reported dyspepsia. Between 64 (GERD) and 92% (UGIB) of these patient-reported PMHs were absent in the corresponding prescribers' reports. This discordance was associated with the following factors: patients of younger age, female patients, less frequent patient-prescriber contact, prescription of NSAID by a specialist, no recent specialist consultation, hospitalization or surgery related to the PMH, and no dispensation of proton-pump inhibitors (PPIs) for digestive disorder-related PMHs. The study showed that a substantial proportion of prescribers seemed unaware of the presence of risk-related PMHs that the patient reported when asked.
authors.affiliation: Department of Pharmacology, Université de Bordeaux, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Fourrier-Réglat
authors.forename: L
authors.initials: L
authors.lastname: Lacoin
authors.forename: A
authors.initials: A
authors.lastname: Pariente
authors.forename: R
authors.initials: R
authors.lastname: Lassalle
authors.forename: P
authors.initials: P
authors.lastname: Robinson
authors.forename: C
authors.initials: C
authors.lastname: Droz-Perroteau
authors.forename: B
authors.initials: B
authors.lastname: Bégaud
authors.forename: P
authors.initials: P
authors.lastname: Blin
authors.forename: N D
authors.initials: ND
authors.lastname: Moore
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001291:Attitude of Health Personnel; D001364:Awareness; D011307:Drug Prescriptions; D004363:Drug Utilization; D005260:Female; D005602:France; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy; D019538:Health Care Surveys; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D016017:Odds Ratio; D010817:Physician-Patient Relations; D010818:Practice Patterns, Physicians'; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012017:Referral and Consultation; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors