Driving biochemical discovery with quantitative proteomics.
Proteomic analysis of biological samples plays an increasing role in modern research. Although the application of proteomics technologies varies across many disciplines, proteomics largely is a tool for discovery that then leads to novel hypotheses. In recent years, new methods and technologies have been developed and applied in many areas of proteomics, and there is a strong push towards using proteomics in a quantitative manner. Indeed, mass spectrometry-based, quantitative proteomics approaches have been applied to great success in a variety of biochemical studies. In particular, the use of quantitative proteomics provides new insights into protein complexes and post-translational modifications and leads to the generation of novel insights into these important biochemical systems.
Washburn
Michael P
MP
Stowers Institute for Medical Research, Kansas City, 1000 E. 50(th) St., MO 64110, USA. mpw@stowers.org
D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods*