Protective effect of calcium folinate against methotrexate-induced endosalpinx damage in rats.
The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX.
Yang
Xiao-Jun
XJ
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China.
Chen
Yan-Ping
YP
Wang
Han-Chu
HC
Zhao
Jing
J
Zheng
Fei-Yun
FY
D000818:Animals; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D002955:Leucovorin / Q000494:pharmacology*; D008727:Methotrexate / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D020011:Protective Agents; D002955:Leucovorin; D008727:Methotrexate