Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.
Trilateral retinoblastoma (TRB) is a rare condition characterized by an intracranial neuroblastic tumor associated with bilateral or unilateral retinoblastoma (RB). The outcome is almost always fatal. An 18-month-old patient with familial bilateral RB was referred for a pineal lesion detected on a screening by magnetic resonance imaging. The child, considered inoperable by 2 different neurosurgical teams, was treated with conventional chemotherapy (methotrexate, vincristine, vepeside, cyclophosphamide, and carboplatin) plus tandem transplantation (vepeside/carboplatin and thiotepa/mephalan) followed by local radiotherapy. At 80 months from the diagnosis of TRB, the patient is alive and in complete remission, with no neuropsychologic consequences. An early and aggressive treatment may improve the prognosis of TRB.
De Ioris
Maria Antonietta
MA
Division of Pediatric Oncology Unit, Ospedale Pediatrico Bambino Gesù, Rome, Italy. deioris@opbg.net
Fidani
Paola
P
Munier
Francis L
FL
Serra
Annalisa
A
Ilari
Ilaria
I
Popovic
Maya Beck
MB
Natali
Gianluigi
G
Secco
Domitilla Elena
DE
Cozza
Raffaele
R
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D010871:Pinealoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D011829:Radiation Dosage; D011878:Radiotherapy; D012074:Remission Induction; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*