title: Study on the changes of urinary 8-hydroxydeoxyguanosine levels and burden of heavy metal around e-waste dismantling site.
abstract: To examine the relations between the burden of blood copper (B-Cu), blood ferrous (B-Fe), and the oxidative stress in people around electronic waste (e-waste) recycling sites, this study measured and analyzed the level of urinary 8-Hydroxy-2'-deoxyguanosine (8-OHDG) of these people. Exposed groups, consisted of female groups (directly exposed group n=100, indirectly exposed group n=54) and male groups (directly exposed group n=98, indirectly exposed group n=34), were chosen from e-waste recycling sites. Control group (female n=59, male=32) was selected from a green plantation. Questionnaire surveys for risk factors were also performed. Results indicated the male directly exposed group (lg8-OHDG nmol/mol creatinine, mean±SD, 3.55±0.49) showed a lower 8-OHDG level than the male control group (lg8-OHDG nmol/mol creatinine, mean±SD, 3.89±0.29) (p<0.01), Meanwhile, an elevated B-Fe in male directly exposed group (lgB-Fe ug/L 3.11±0.25) were observed compared with the male control group (lgB-Fe ug/L 2.83±0.22) (p<0.01). The levels of urinary 8-OHDG were negatively associated with blood ferrous, as confirmed by linear regression model (unstandardized regression coefficient, beta=-0.215, p<0.05). The present study suggests that the exposure to e-waste might cause the elevation of B-Fe and result in the changes of urinary 8-OHDG levels.
authors.affiliation: Department of Environment and Health, Chinese Research Academy of Environmental Sciences, 100012, PR China. wanghmxj@163.com
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.forename: Shihai
authors.initials: S
authors.lastname: Lv
authors.forename: Fasheng
authors.initials: F
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Shen
authors.initials: S
authors.lastname: Ke
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D001822:Body Burden; D003300:Copper / Q000097:blood*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D055615:Electrical Equipment and Supplies; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012037:Refuse Disposal; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D003300:Copper; D000080242:8-Hydroxy-2'-Deoxyguanosine; D007501:Iron; D003849:Deoxyguanosine