Hydrocodone: does it have a role in palliative care?
Hydrocodone is an epoxy-methoxy-methylmorphinan semisynthetic opioid (6-deoxy-3-O-methyl-6-oxomorphine hydrogen tartrate hemipentahydrate), which is structurally related to codeine, and is classified as a step 2 opioid on the World Health Organization's stepladder for pain. Hydrocodone is typically found in fixed dose combination with acetaminophen and is often used for pain management. Hydrocodone is a heavily prescribed drug and it is important to understand the evidence base that is guiding this use. This article reviews the pharmacodynamics, pharmacology, and evidence base for the use of hydrocodone in palliative care.
Prommer
Eric
E
Department of Hematology/Oncology/Palliative Care, Mayo Clinic, Phoenix, Arizona, USA.
D000698:Analgesia / Q000191:economics / Q000379:methods*; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D016527:Drug Costs; D019317:Evidence-Based Medicine; D006801:Humans; D006853:Hydrocodone / Q000009:adverse effects* / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000191:economics; D010166:Palliative Care / Q000191:economics / Q000379:methods*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D006853:Hydrocodone