Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.
BACKGROUND
Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.


OBJECTIVE
The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.


METHODS
A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP.


RESULTS
The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.


CONCLUSIONS
This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
Moreno-Galván
Mónica
M
Centro Nacional de Vigilancia Epidemiológica y Control de Enfermedades, SSA, Mexico City, Mexico.
Herrera-González
Norma Estela
NE
Robles-Pérez
Vera
V
Velasco-Rodríguez
Julio C
JC
Tapia-Conyer
Roberto
R
Sarti
Elsa
E
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000502:physiology; D003271:Contraceptive Agents, Female / Q000009:adverse effects; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000502:physiology; D004967:Estrogens / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D009376:Neoplasms, Hormone-Dependent / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D017584:Reproductive History; D012306:Risk; D012907:Smoking / Q000453:epidemiology
D003271:Contraceptive Agents, Female; D004967:Estrogens; D009363:Neoplasm Proteins; D019363:Cytochrome P-450 CYP1A1; D002394:Catechol O-Methyltransferase