Towards a cure for HIV: the identification and characterization of HIV reservoirs in optimally treated people.
Currently available anti-HIV-1 drugs suppress viral replication and maintain viral levels below the detection threshold of most assays but do not eliminate cellular reservoirs. As a result, very low levels of circulating virus can be detected in most people despite long-term treatment with potent anti-HIV drug combinations. Not surprisingly, viral levels rebound with discontinuation of treatment. New evidence indicates that there is a viral reservoir in bone marrow progenitor cells.
Onafuwa-Nuga
Adewunmi
A
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
McNamara
Lucy A
LA
Collins
Kathleen L
KL
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018952:Antigens, CD34 / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D016655:HIV Core Protein p24 / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D013234:Stem Cells / Q000821:virology; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D018952:Antigens, CD34; D016655:HIV Core Protein p24; D012367:RNA, Viral