Chronic effect of ferulic acid from Pseudosasa japonica leaves on enhancing exercise activity in mice.
Ferulic acid derived from Pseudosasa japonica leaves, which possessed antioxidative potentials with DPPH- (54%) and ABTs- (65%) radical scavenging activities, and lipid-peroxidation inhibitory activity (71%), was orally administered to mice for 12 days in order to investigate its effects on exercise endurance capacity and alterations of antioxidant defense systems. Exhaustive swimming time was increased in the ferulic acid-supplemented group compared with the control group on days 6 and 12 (1.7- and 1.8-fold, respectively). When the mice were exhaustively exercised for 2 consecutive days, a high decrease (53%) was shown in the control group, but no change was found in the ferulic acid-treated group. The administration of ferulic acid significantly protected the depletion of enzymatic- and non enzymatic-antioxidants due to exhaustive exercise. Also, lipid-peroxidation levels decreased in the ferulic acid-treated group compared with the non exercised- and control-groups. These results suggest that ferulic acid from Pseudosasa japonica leaves has a chronic effect on endurance exercise capacity, which is attributed to its ability to ameliorate oxidative stress by improving antioxidant potentials.
You
Yanghee
Y
Department of Food and Nutrition, Chonnam National University, Gwangju 550-757, Korea.
Kim
Kyungmi
K
Yoon
Ho-Geun
HG
Lee
Kwang-Won
KW
Lee
Jeongmin
J
Chun
Jiyeon
J
Shin
Dong-Hoon
DH
Park
Jeongjin
J
Jun
Woojin
W
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D010807:Physical Endurance / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D006109:Poaceae / Q000737:chemistry*; D013550:Swimming
D000975:Antioxidants; D003373:Coumaric Acids; D016166:Free Radical Scavengers; C004999:ferulic acid