Clinical implication of CD166 expression in gastric cancer.
BACKGROUND
CD166 is one of the cell-surface immunoglobulins, and is well known to regulate leukocyte mobility. Its expression is associated with aggressive tumor behavior. CD166 expression is a prognostic marker in several cancers, but the predictive value of CD166 expression in gastric cancer has not been clarified yet.


METHODS
A total of 142 gastric cancer patients who consecutively received curative gastrectomy in Kagoshima University Hospital were enrolled in the current study. The patients were composed of 99 men and 43 women, ranging in age from 42 to 84 years (mean 63 years). Cancerous CD166 expression was evaluated immunohistochemically.


RESULTS
Cancerous CD166 expression was identified in not only cellular membrane but also cytoplasm. The rates of membranous and cytoplasmic CD166 positivities were 25.4% and 34.4%, respectively. Cytoplasmic and membranous CD166 positivities were significantly correlated with nodal involvement and vascular invasion. Survival analysis of the 142 gastric cancer patients revealed that membranous CD166-positive group (median survival 18.6 months, range 0.3-104.5 months) had a significantly poorer outcome than CD166-negative group (median 25.7 months range 1.4-106 months) (P < 0.05).


CONCLUSIONS
Membranous CD166-positivity may contribute to one of the promising prognostic markers in gastric cancer.
Ishigami
Sumiya
S
Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan. ishiga@m.kufm.kagoshima-u.ac.jp
Ueno
Shinichi
S
Arigami
Takaaki
T
Arima
Hideo
H
Uchikado
Yasuto
Y
Kita
Yoshiaki
Y
Sasaki
Ken
K
Nishizono
Yuka
Y
Omoto
Itaru
I
Kurahara
Hiroshi
H
Matsumoto
Masataka
M
Kijima
Yuko
Y
Natsugoe
Shoji
S
D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis
D020410:Activated-Leukocyte Cell Adhesion Molecule; D014408:Biomarkers, Tumor