title: Continuous-flow synthesis of vitamin D3.
abstract: A highly efficient, two-stage, continuous-flow synthesis of vitamin D(3) from provitamin D(3) was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1-H-101, Ookayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Fuse
authors.forename: Nobutake
authors.initials: N
authors.lastname: Tanabe
authors.forename: Masahito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hayato
authors.initials: H
authors.lastname: Yoshida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D002762:Cholecalciferol / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003684:Dehydrocholesterols / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D003684:Dehydrocholesterols; D002762:Cholecalciferol; C016705:7-dehydrocholesterol