[Preparation of self-emulsifying soft capsule and its pharmacokinetic in rats for epimedium flavonoids].
OBJECTIVE
To study the formulation optimization of epimedium flavonoids self-emulsifying drug delivery system and evaluate its effect in vitro and in vivo.


METHODS
Based on the degree of emulsification and emulsifying time, the formulation optimization (i.e., screening of suitable oil phases, nonionic surfactants and co-surfactants) was made by the use of determination of the solubility, orthogonal design and construction of tertiary phase diagram. The dissolution of SEDDS was measured and its pharmacokinetic in rats was measured.


RESULTS
The experimental results revealed the optimized formulation of the self-emulsifying drug delivery system which consisted of oleic acid as oil phase, Tween-80 as nonionic surfactant, and PEG400 as co-surfactant in the proportion of 2:4:4. The dissolution of SEDDS in water was more than 85% in 25 minutes, while that of the epimedium flavonoids capsule was less than 50% in 60 minutes.


CONCLUSIONS
Application of the optimized formulation of epimedium flavonoids self-emulsifying drug delivery system could significantly increase the solubility of epimedium flavonoids in water and improve its bioavailability.
Jiang
Yong-nan
YN
Guangdong Food and Drug Vocational College, Guangzhou 510520, China. jiangyn@gdyzy.edu.cn
Mo
Hong-ying
HY
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004655:Emulsions; D034181:Epimedium / Q000737:chemistry*; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D019301:Oleic Acid; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
D002214:Capsules; D004655:Emulsions; D005419:Flavonoids; D013501:Surface-Active Agents; D019301:Oleic Acid