title: In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids.
abstract: The in vitro effects of the ω-3 polyunsaturated fatty acids (PUFAs) eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) on phagocytosis and the extracellular respiratory burst in caprine monocytes were assessed. Blood monocytes incubated with increasing concentrations of EPA or DHA (25-200 μM) demonstrated increased phagocytosis compared to unexposed monocytes. Generation of reactive oxygen species (ROS) was not markedly affected in the presence of EPA and DHA, except at 200 μM, at which concentrations monocyte viability was also reduced.
authors.affiliation: Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Università di Milano, via Celoria 10, 20133 Milano, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Lecchi
authors.forename: Guido
authors.initials: G
authors.lastname: Invernizzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Agazzi
authors.forename: Mariella
authors.initials: M
authors.lastname: Ferroni
authors.forename: Laura Francesca
authors.initials: LF
authors.lastname: Pisani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Savoini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ceciliani
mesh_terms: D000818:Animals; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D006041:Goats / Q000276:immunology*; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D010587:Phagocytosis; D017382:Reactive Oxygen Species / Q000276:immunology* / Q000378:metabolism; D016897:Respiratory Burst
chemical_list: D017382:Reactive Oxygen Species; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid