Spherical N-carboxyethylchitosan/hydroxyapatite nanoparticles prepared by ionic diffusion process in a controlled manner.
The nanocomposites containing hydroxyapatite (HA) and biomacromolecules have attracted considerable research interest in implants, tissue scaffolds and drug controlled delivery. In this study, the N-carboxyethylchitosan/hydroxyapatite (NCECS/HA) nanoparticles were prepared by the ionic diffusion process in a controlled manner. The crystallization, particle size, size distribution and aggregation morphology of the NCECS/HA nanocomposites were dependent on the mole ratio of the glucosamine unit in NCECS to the Ca(2+). Fourier transform-infrared spectroscopic (FTIR) result indicated that there are chemical bonds formed between NCECS and HA. X-ray diffraction (XRD) analysis showed that the crystallization of HA in NCECS matrix was significantly retarded. Transmission electron microscopy (TEM) results revealed that NCECS/HA nanocomposites have the spherical morphology with the diameter ranging from 10 to 40 nm. The NCECS mineralization is driven by the self-assembly of NCECS and HA. These NCECS/HA nanocomposites have potential applications as the carrier for the controlled delivery of growth factors and drugs.
Zhu
Aiping
A
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, People's Republic of China. apzhu@yzu.edu.cn
Lu
Yan
Y
Zhou
Yao
Y
Dai
Sheng
S
D048271:Chitosan / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D003460:Crystallization; D004058:Diffusion; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D044367:Phase Transition; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D014867:Water / Q000494:pharmacology; D014961:X-Ray Diffraction
D014867:Water; D048271:Chitosan; D017886:Durapatite