Bacterial exploitation of host cell signaling.
As a way of enhancing infections, bacterial pathogens often alter host cell signaling pathways. Here, we describe recent work that highlights a new phosphatase from an intestinal and wound-invading pathogen that manipulates host cell phosphoinositide circuits. Despite the active-site homology between bacterial inositol phosphatases and mammalian phosphatases, sequence differences between them suggest that the development of specific inhibitors may be feasible.
Lu
Richard
R
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Cambridge, MA 02139, USA.
Goldberg
Marcia B
MB
D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D002477:Cells / Q000378:metabolism* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D015398:Signal Transduction