title: [A study on the relationship between HPV infection and the oncogenesis of primary squamous carcinoma of the lung.].
abstract: BACKGROUND
  To research the relationship between human papillomavirus (HPV) infection and the oncogenesis of primary squamous carcinoma of the lung.
  
  
  METHODS
  50 formalin-fixed paraffin-embedded tissues of squamous cell carcinoma of the lung , 30 samples of areas of squamous epithelium metaplasia near tumors , and 30 samples of normal bronchial mucosa were detected for the presence of HPV DNA by polymerase chain reaction (PCR) .
  
  
  RESULTS
  In these samples , the positive detection rate of HPV DNA was 26%, 36.7% and 10% respectively. Of the detected HPV DNA , HPV16 was of the highest ratio. The positive rate of HPV6/11 and HPV16 in squamous cell carcinoma and squamous epithelium metaplasia had no significant difference by Chi-Square test ( P > 0. 05) .
  
  
  CONCLUSIONS
  These results suggest that HPV infection might play an important role in the oncogenesis of squamous cell carcinomas of the lung , and squamous epithelium metaplasia of the bronchus could be regarded as a precancer lesion. Compared with biotinylated DNA probes and hybridization technique , PCR has a higher sensitivity.
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, P.R.China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Dong
authors.forename: L
authors.initials: L
authors.lastname: Peng
authors.forename: J
authors.initials: J
authors.lastname: Ling
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: H
authors.initials: H
authors.lastname: Zhuang