In vitro antimicrobial activity of Brazilian medicinal plant extracts against pathogenic microorganisms of interest to dentistry.
This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebinthifolius (aroeira), Croton campestris (velame), Lafoensia pacari (pacari), Centaurium erythraea (centáurea), Stryphnodendron adstringens (barbatimão), and Anacardium humile (cajuzinho-docerrado), as compared to standardized antimicrobial agents (nystatin, chloramphenicol and tetracycline hydrochloride). Ethanol, hexane and butane fractions from stem barks, rinds, leaves, and/or roots were extracted and tested. Antimicrobial diffusion agar test and MIC were performed according to CLSI. After 24 h of incubation at 37 °C, the diameter of inhibition zones and spectrophotometer readings were measured and compared. The results were reported as means ± standard deviation (M ± SD). With the exception of five extracts that showed no antimicrobial activity, all the extracts tested showed antimicrobial activity, in different levels. This study suggests that extracts from the plants tested could be an alternative therapeutic option for infectious conditions of the oral cavity, such as denture stomatitis, dental caries, and periodontitis.
Pereira
Elizete Maria
EM
Laboratory of Microbiology and Biomaterials, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Gomes
Rafael Tomaz
RT
Freire
Natália Ribeiro
NR
Aguiar
Evandro Guimarães
EG
Brandão
Maria das Graças Lins
Md
Santos
Vagner Rodrigues
VR
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001938:Brazil; D002176:Candida albicans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018514:Plant Structures; D010946:Plants, Medicinal; D009057:Stomatognathic Diseases / Q000382:microbiology*
D000890:Anti-Infective Agents; D010936:Plant Extracts