Malignant peripheral nerve sheath tumour in the liver of a dog.
A 14-year-old male mixed breed dog was presented for abdominal distension and abdominal pain. Radiographical examination identified a large space-occupying mass in the abdomen. Necropsy examination revealed the presence of a 12cm hepatic mass that occupied almost half of the abdominal cavity. Microscopically, this mass consisted of spindle-shaped neoplastic cells that were arranged in short streams and interlacing bundles. Immunohistochemically, the neoplastic cells expressed vimentin, S-100, protein gene product 9.5 and neuron specific enolase, but were negative for cytokeratin, smooth muscle actin, melan A and von Willebrand Factor. These findings indicated that the hepatic mass was a primary hepatic peripheral nerve sheath tumour. To our knowledge, this is the first documentation of a primary hepatic malignant peripheral nerve sheath tumour in a dog.
Park
J-W
JW
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Woo
G-H
GH
Jee
H
H
Jung
D-W
DW
Youn
H-Y
HY
Choi
M-C
MC
Kim
D-Y
DY
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase