title: [Creatinine: past and present].
abstract: Serum creatinine is certainly one of the most prescribed biological parameters. In this review article, we remind some historical data regarding creatinine. Different methodologies to measure creatinine in blood and urine are deeply described. We also discuss the physiological reason for its use as a glomerular filtration rate marker. However, analytical and physiological limitations are described and discussed. Creatinine clearance usefulness is finally largely discussed.
authors.affiliation: Service de néphrologie-dialyse-transplantation rénale, CHU Sart Tilman, Liège, Belgium. pierre_delanaye@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.forename: Nicolas
authors.initials: N
authors.lastname: Maillard
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariat
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Laurence
authors.initials: L
authors.lastname: Piéroni
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood* / Q000652:urine; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D003404:Creatinine