title: Measures for characterizing directionality specific volume changes in TBM of brain growth.
abstract: Tensor based morphology (TBM) is a powerful approach to analyze local structural changes in brain anatomy. However, conventional scalar TBM methods are unable to present direction-specific analysis of volume changes required to model complex changes such as those during brain growth. In this paper, we describe novel TBM descriptors for studying direction-specific changes in a subject population which can be used in conjunction with scalar TBM to analyze local patterns in directionality of volume change during brain development. We illustrate the use of these methods by studying brain developmental patterns in fetuses. Results show that this approach detects early changes local growth that are related to the early stages of sulcal and gyral formation.
authors.affiliation: Biomedical Image Computing Group, University of California San Francisco, San Francisco, CA 94143, USA. vidya.rajagopalan@ucsf.edu
authors.forename: Vidya
authors.initials: V
authors.lastname: Rajagopalan
authors.forename: Julia
authors.initials: J
authors.lastname: Scott
authors.forename: Piotr A
authors.initials: PA
authors.lastname: Habas
authors.forename: Kio
authors.initials: K
authors.lastname: Kim
authors.forename: Francois
authors.initials: F
authors.lastname: Rousseau
authors.forename: Orit A
authors.initials: OA
authors.lastname: Glenn
authors.forename: A James
authors.initials: AJ
authors.lastname: Barkovich
authors.forename: Colin
authors.initials: C
authors.lastname: Studholme
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009929:Organ Size / Q000502:physiology; D010363:Pattern Recognition, Automated / Q000379:methods*; D011296:Prenatal Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity