Severe Plasmodium vivax malaria, Brazilian Amazon.
We describe a case series of 17 patients hospitalized in Manaus (western Brazilian Amazon) with PCR-confirmed Plasmodium vivax infection who were treated with chloroquine and primaquine. The major complications were jaundice and severe anemia. No in vivo chloroquine resistance was detected. These data help characterize the clinical profile of severe P. vivax malaria in Latin America.
Alexandre
Márcia A
MA
Fundacao de Medicina Tropical do Amazonas, Manaus, Brazil.
Ferreira
Cynthia O
CO
Siqueira
André M
AM
Magalhães
Belisa L
BL
Mourão
Maria Paula G
MP
Lacerda
Marcus V
MV
Alecrim
Maria das Gracas C
Md
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000962:Antimalarials / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016780:Malaria, Vivax / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D011319:Primaquine / Q000627:therapeutic use; D012720:Severity of Illness Index; D055815:Young Adult
D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine