Evaluation of loop ligation of larger myoma pseudocapsule combined with vasopressin on laparoscopic myomectomy.
OBJECTIVE
To study the effects of reducing hemorrhage by loop ligation of larger myoma pseudocapsules combined with vasopressin on laparoscopic myomectomy (LM).


METHODS
Prospective controlled clinical trial.


METHODS
Sheng Jing Hospital, China Medical University.


METHODS
A total of 105 women with symptomatic single or multiple larger myomas (diameter 6-18 cm) in need of surgical intervention, who wished to retain their uteri, were randomly divided into three groups in our hospital from January 2006 to January 2008: A) loop ligation combined with vasopressin; B) vasopressin alone; and C) neither loop ligation nor vasopressin. All patients were treated by LM. Each group included 35 cases.


METHODS
Loop ligation of larger myoma (6-18 cm) pseudocapsule combined with vasopressin before thoroughly enucleating the myoma.


METHODS
Operating time, blood loss, blood transfusion, postoperative stay in hospital, symptom improvement.


RESULTS
Average blood loss, postoperative stay in hospital, number of conversions to laparotomy, and need for transfusion because of bleeding during operation in group A were significantly lower than in groups B and C. All patients in group A underwent technically successful laparoscopic operations.


CONCLUSIONS
Loop ligation of larger myoma pseudocapsules combined with vasopressin is a safe, effective, and promising new method to reduce bleeding during laparoscopic myomectomy and makes the laparoscopic operations with larger myomas easier.
Zhao
Fujie
F
Obstetrics and Gynecology Department, Shengjing Hospital, China Medical University, Shen Yang City, People's Republic of China. zhaofujie63@yahoo.com.cn
Jiao
Yisheng
Y
Guo
Zhiqiang
Z
Hou
Rui
R
Wang
Min
M
D000328:Adult; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D007889:Leiomyoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008026:Ligation / Q000379:methods; D008875:Middle Aged; D047368:Tumor Burden; D055988:Uterine Artery / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D014667:Vasopressins / Q000008:administration & dosage*; D055815:Young Adult
D014662:Vasoconstrictor Agents; D014667:Vasopressins