Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.
A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method.
Malet-Sanz
Laia
L
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW. laia.malet@pfizer.com
Madrzak
Julia
J
Ley
Steven V
SV
Baxendale
Ian R
IR
D001391:Azo Compounds / Q000737:chemistry*; D002712:Chlorides / Q000138:chemical synthesis*; D008024:Ligands; D015394:Molecular Structure; D013457:Sulfur Compounds / Q000737:chemistry*
D001391:Azo Compounds; D002712:Chlorides; D008024:Ligands; D013457:Sulfur Compounds