title: Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study.
abstract: BACKGROUND
  Lipocalin-2 and adipocyte fatty-acid-binding protein (A-FABP or FABP4) are adipokines potentially involved in the pathophysiology of obesity and metabolic syndrome in adults. In children, they have been scarcely studied.
  
  
  OBJECTIVE
  To analyze lipocalin-2 and A-FABP circulating levels before and after 2 years of a dieting and lifestyle intervention in a prepubertal obese cohort.
  
  
  METHODS
  Case-control study with a prospective follow-up of cases for 2 years in our referral pediatric endocrine outpatient center.
  
  
  METHODS
  Seventy-three prepubertal obese children, 8.03 ± 1.08-years old, and 47 age- and gender-matched lean controls were studied. Anthropometric parameters, blood pressure, fasting oral glucose tolerance test, homeostatic model insulin resistance index (HOMA-IR), lipid profile, lipocalin-2, and A-FABP were evaluated. Weight loss was considered if z-score body mass index (BMI) decreased at least 0.5 s.d.
  
  
  RESULTS
  At baseline, lipocalin-2 and A-FABP were higher in prepubertal obese children than those in lean controls (P<0.001). A-FABP showed a gradual increase, according to the obesity degree (r(2)=0.632; P<0.001). After 2 years, obese patients who lost weight showed a decrease in A-FABP (a mean 2% reduction in BMI was associated with a mean 29% decrease in A-FABP (P<0.001)) without changes in lipocalin-2 levels. Regression model analysis adjusted by age, sex, BMI, and HOMA showed that A-FABP was lower in males (β=-5.77 (CI 95%: -9.7; -1.84)) and was modified by BMI (β=2.7 (CI 95%: 1.77-3.62), r(2)=0.659). Lipocalin-2 was not modified by any of these variables.
  
  
  CONCLUSIONS
  Prepubertal obese children show high plasma lipocalin-2 and A-FABP levels, but only A-FABP is influenced by weight loss.
authors.affiliation: Department of Pediatric Endocrinology, Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autònoma de Barcelona (UAB), C/Parc Taulí SN, 08208 Sabadell, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Corripio
authors.forename: José-Miguel
authors.initials: JM
authors.lastname: Gónzalez-Clemente
authors.forename: Jacobo
authors.initials: J
authors.lastname: Pérez-Sánchez
authors.forename: Sílvia
authors.initials: S
authors.lastname: Näf
authors.forename: Lluís
authors.initials: L
authors.lastname: Gallart
authors.forename: Ramon
authors.initials: R
authors.lastname: Nosàs
authors.forename: Joan
authors.initials: J
authors.lastname: Vendrell
authors.forename: Assumpta
authors.initials: A
authors.lastname: Caixàs
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D054834:Lipocalins / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000378:metabolism; D015431:Weight Loss / Q000502:physiology*
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D054834:Lipocalins