title: Increased incidence of colorectal malignancies in renal transplant recipients: a case control study.
abstract: This study was to evaluate the frequency of colorectal neoplasia in renal transplant recipients and to investigate the association with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. We compared the frequency of colorectal neoplasia among renal transplant recipients with that of the healthy subjects. Specimens of colorectal neoplasia were examined for EBV and CMV using in situ hybridization and immunohistochemistry, respectively. Of 796 renal transplantation cohorts, 315 were enrolled. The frequency of colorectal neoplasia among the patients was 22.9%. Compared with the healthy subjects, the odds ratio (OR) for advanced adenoma was 3.32 (95% CI, 1.81-6.10). The frequency of cancer among the patients was 1.9% (OR, 12.0; 95% CI, 1.45-99.7). A long interval between transplantation and colonoscopy was a significant factor in the development of advanced colorectal neoplasia. EBV positivity was detected in 30.6% of colorectal neoplasia specimens from renal transplant recipients, which was higher than that for the controls (p = 0.002). CMV was not detected in any lesions of patients or controls. In conclusion, renal transplant recipients have a significantly increased risk of advanced colorectal neoplasia. EBV was more frequently found in specimens of advanced colorectal neoplasm obtained from the renal transplant recipients.
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: J M
authors.initials: JM
authors.lastname: Park
authors.forename: M-G
authors.initials: MG
authors.lastname: Choi
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.forename: I-S
authors.initials: IS
authors.lastname: Chung
authors.forename: C W
authors.initials: CW
authors.lastname: Yang
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: C K
authors.initials: CK
authors.lastname: Jung
authors.forename: K Y
authors.initials: KY
authors.lastname: Lee
authors.forename: J-H
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification; D018450:Disease Progression; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D015994:Incidence; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011183:Postoperative Complications / Q000453:epidemiology*; D018570:Risk Assessment; D013997:Time Factors; D055815:Young Adult