Commentary: the year in nuclear receptor control of metabolism.
This commentary highlights some of the most important discoveries in the field of nuclear receptor control of metabolism that occurred over the past year (2009 to 2010). As might be expected in a field that encompasses several hundred active laboratories, the task of providing a balanced look at these discoveries was daunting. Thus, to help make the selection of these discoveries, a small panel of colleagues was recruited to help. After selecting the top candidate discoveries from a Google search and a PubMed search, the panel was asked to rank them. These final selections were presented at "The Year In Basic Science Session" of the Annual Meeting of the Endocrine Society, ENDO 2010, the highlights of which are reproduced in this article.
Mangelsdorf
David J
DJ
University of Texas Southwestern Medical Center, Howard Hughes Medical Institute, Department of Pharmacology, 6001 Forest Park Road, Room ND9.124A, Dallas, TX 75390-9050, USA. davo.mango@utsouthwestern.edu
D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D001862:Bone Resorption / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000378:metabolism; D065150:Cellular Reprogramming; D002784:Cholesterol / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis; D006801:Humans; D007662:Ketosis / Q000378:metabolism; D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D010012:Osteogenesis; D047493:PPAR alpha / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012098:Reproduction; D013217:Starvation; D058207:Sumoylation; D014157:Transcription Factors / Q000378:metabolism
D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047493:PPAR alpha; D047495:PPAR gamma; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C414620:fibroblast growth factor 21; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D006418:Heme; D005346:Fibroblast Growth Factors; D002784:Cholesterol