title: Outcomes after a purely endoscopic transsphenoidal resection of growth hormone-secreting pituitary adenomas.
abstract: OBJECTIVE
  Using strict biochemical remission criteria, the authors assessed surgical outcomes after endoscopic transsphenoidal resection of growth hormone (GH)-secreting pituitary adenomas and identified preoperative factors that significantly influence the rate of remission.
  
  
  METHODS
  A retrospective review of a prospectively maintained database was performed. The authors reviewed cases in which an endoscopic resection of GH-secreting pituitary adenomas was performed. The cohort consisted of 26 patients who had been followed for 3-60 months (mean 24.5 months). The thresholds of an age-appropriate, normalized insulin-like growth factor-I concentration, a nadir GH level after oral glucose load of less than 1.0 μg/l, and a random GH value of less than 2.5 μg/l were required to establish biochemical cure postoperatively.
  
  
  RESULTS
  Overall, in 57.7% of patients undergoing a purely endoscopic transsphenoidal pituitary adenectomy for acromegaly, an endocrinological cure was achieved. The mean clinical follow-up duration was 24.5 months. In patients with microadenomas (4 cases) the cure rate was 75%, whereas in patients harboring macroadenomas (22 cases) the cure rate was 54.5%. Cavernous sinus invasion (Knosp Grades 3 and 4) was associated with a significantly lower remission rate (p = 0.0068). Hardy Grade 3 and 4 tumors were also less likely to achieve biochemical cure (p = 0.013). The overall complication rate was 11.5% including 2 incidents of transient diabetes insipidus and 1 postoperative CSF leak, which were treated nonoperatively.
  
  
  CONCLUSIONS
  A purely endoscopic transsphenoidal approach to GH-secreting pituitary adenomas leads to similar outcome for noninvasive macroadenomas compared with traditional microsurgical techniques. Furthermore, this approach may often provide maximal visualization of the tumor, the pituitary gland, and the surrounding neurovascular structures.
authors.affiliation: Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. peter.campbell@jeffersonhospital.org
authors.forename: Peter G
authors.initials: PG
authors.lastname: Campbell
authors.forename: Erin
authors.initials: E
authors.lastname: Kenning
authors.forename: David W
authors.initials: DW
authors.lastname: Andrews
authors.forename: Sanjay
authors.initials: S
authors.lastname: Yadla
authors.forename: Marc
authors.initials: M
authors.lastname: Rosen
authors.forename: James J
authors.initials: JJ
authors.lastname: Evans
mesh_terms: D000172:Acromegaly / Q000601:surgery*; D000236:Adenoma / Q000601:surgery; D000328:Adult; D000368:Aged; D004724:Endoscopy / Q000379:methods*; D005260:Female; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000601:surgery*; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008137:Longitudinal Studies; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019635:Neurosurgical Procedures / Q000379:methods; D010911:Pituitary Neoplasms / Q000601:surgery; D012074:Remission Induction; D013100:Sphenoid Bone; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I