ADC changes in schizophrenia: a diffusion-weighted imaging study.
Studies using diffusion tensor imaging (DTI) have shown multifocal reduction in anisotropy of white matter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P < 0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P < 0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not support ADC changes to be a marker of white matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder.
Nenadic
Igor
I
Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany. igor.nenadic@uni-jena.de
Wagner
Gerd
G
Güllmar
Daniel
D
Schachtzabel
Claudia
C
von Consbruch
Katrin
K
Köhler
Sabine
S
Koch
Kathrin
K
Roebel
Martin
M
Schultz
C Christoph
CC
Reichenbach
Jürgen R
JR
Sauer
Heinrich
H
Schlösser
Ralf G M
RG
D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult