title: The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats.
abstract: The purpose of this study was to investigate the effects of hypercholesterolemia and sulphite on active avoidance learning. Male Wistar rats were divided into eight groups as follows: Control (C), Sulphite (S), Vitamin E (E), Sulphite + Vitamin E (SE), Hypercholesterolemia (H), Hypercholesterolemia + Sulphite (HS), Hypercholesterolemia + Vitamin E (HE), and Hypercholesterolemia + Sulphite + Vitamin E (HSE). At the end of the experimental period, the serum cholesterol level (mean ± SD) was significantly higher in H group (111.5 ± 11.11 mg dL(-1) ) as compared to C group (63.5 ± 4.9 mg dL(-1) ). Levels of thiobarbituric acid reactive substances (TBARS) were increased in HS group as compared to C, H, and S groups. Vitamin E reduced TBARS levels in HSE group compared with HS group. Active avoidance results indicated that hypercholesterolemia was associated with learning impairment. Our data clearly revealed that the combination of hypercholesterolemia and sulphite results in exaggerated impairment of active avoidance. Vitamin E improved active avoidance in HSE group compared with HS group. Therefore, the synergistic effect of hypercholesterolemia and sulphite may be associated with a considerable health risk.
authors.affiliation: Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozsoy
authors.forename: Gulay
authors.initials: G
authors.lastname: Hacioglu
authors.forename: Feyza
authors.initials: F
authors.lastname: Savcioglu
authors.forename: Vural
authors.initials: V
authors.lastname: Kucukatay
authors.forename: Piraye
authors.initials: P
authors.lastname: Yargicoglu
authors.forename: Aysel
authors.initials: A
authors.lastname: Agar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects; D006937:Hypercholesterolemia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009573:Nitrites / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013447:Sulfites / Q000633:toxicity*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D009573:Nitrites; D013447:Sulfites; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; C005200:sodium metabisulfite; D002784:Cholesterol