title: Skeletal aging and the adipocyte program: New insights from an "old" molecule.
abstract: Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, time-keeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging.
authors.affiliation: Department of Orthopaedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, USA.
authors.forename: Beata
authors.initials: B
authors.lastname: Lecka-Czernik
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Rosen
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kawai
mesh_terms: D017667:Adipocytes / Q000378:metabolism* / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D047495:PPAR gamma; D014157:Transcription Factors; C102804:nocturnin; D007334:Insulin-Like Growth Factor I