Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population.
BACKGROUND
Aspirin-intolerant asthma (AIA) occurs in the lower and upper airways through excessive production of leukotrienes upon administration of non-steroidal anti-inflammatory drugs (NSAIDs). One of the three symptoms of AIA is nasal polyposis, a chronic inflammatory disease that is related to the function of calcium ion in recruitment of immune cells during airway inflammation. It has been implicated that bronchodilation in the airway is related to Ca(2+) regulation. The calcium channel, voltage-dependent, gamma subunit 6 (CACNG6) gene encodes a protein that stabilizes the calcium channel.


METHODS
To study the associations between AIA and polymorphisms in CACNG6 gene, eight variants were genotyped in 102 AIA cases and 429 aspirin-tolerant asthma (ATA) controls. Logistic analyses were used to evaluate the associations of CACNG6 polymorphisms with AIA.


RESULTS
Statistical analyses revealed that a single nucleotide polymorphism (SNP; rs192808C > T; P = 0.0004, Pcorr = 0.0029, OR = 2.88 in co-dominant model; P = 0.0005, Pcorr = 0.0036, OR = 2.99 in dominant model) in intron and a haplotype unique to this variant (CACNG6_BL1_ht6; P = 0.003, Pcorr = 0.02, OR = 2.57 in co-dominant model, P = 0.001, Pcorr = 0.0087, OR = 2.81 in dominant model) were significantly associated with the risk of AIA.


CONCLUSIONS
Our results suggest that the CACNG6 variants might be associated with the risk of AIA in a Korean population.
Lee
Jin Sol
JS
Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea.
Kim
Jeong-Hyun
JH
Bae
Joon Seol
JS
Kim
Jason Yongha
JY
Park
Tae Joon
TJ
Pasaje
Charisse Flerida
CF
Park
Byung-Lae
BL
Cheong
Hyun Sub
HS
Uh
Soo-Taek
ST
Park
Jong-Sook
JS
Jang
An-Soo
AS
Kim
Mi-Kyeong
MK
Choi
Inseon S
IS
Park
Choon-Sik
CS
Shin
Hyoung Doo
HD
D055963:Asthma, Aspirin-Induced / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D056910:Republic of Korea
C521177:CACNG6 protein, human; D015220:Calcium Channels