AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings.
AIDS&#x2010;associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource&#x2010;limited settings. Itraconazole poorly penetrates the central nervous system, whereas fluconazole has poor activity against P. marneffei. We prospectively report management of 1 patient and retrospectively review 7 coinfection cases from Vietnam.
Le
Thuy
T
Wellcome Trust Major Overseas Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. thuyl@oucru.org
Hong Chau
Tran Thi
TT
Kim Cuc
Ngo Thi
NT
Si Lam
Pham
P
Manh Sieu
Tran Phu
TP
Shikuma
Cecilia M
CM
Day
Jeremy N
JN
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000302:isolation & purification*; D003906:Developing Countries; D003937:Diagnosis, Differential; D015725:Fluconazole / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D010407:Penicillium / Q000187:drug effects / Q000302:isolation & purification*; D011446:Prospective Studies; D012189:Retrospective Studies; D014744:Vietnam
D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole