Retrospective analysis of hysteroscopic findings in breast cancer patients having adjuvant tamoxifen treatment.
OBJECTIVE
To evaluate the effects of tamoxifen on the endometrium of breast cancer patients by hysteroscopy and endometrial sampling.


METHODS
Thirty-seven breast cancer patients using tamoxifen underwent hysteroscopy because of postmenopausal endometrial thickening or abnormal uterine bleeding. Hysteroscopic findings were compared with histopathology and ultrasonographic measurement of the endometrium.


RESULTS
Nineteen women showed endometrial abnormalities (51%) out of 37 patients. Negative and positive predictive values for hysteroscopy in detecting endometrial abnormalities were 100% and 94%, respectively.


CONCLUSIONS
Endometrial surveillance is an important part of gynecological follow-up in breast cancer patients using tamoxifen and the liberal use of hysteroscopy aids in the diagnosis of abnormal endometrium.
Sendag
F
F
Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey. fatih.sendag@ege.edu.tr
Sahin
C
C
Zeybek
B
B
Terek
M Cosan
MC
Oztekin
K
K
Bilgin
O
O
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D012189:Retrospective Studies; D013629:Tamoxifen / Q000009:adverse effects*
D004965:Estrogen Antagonists; D013629:Tamoxifen