Effects of prostaglandin E2 and vascular endothelial growth factor on sperm might lead to endometriosis-associated infertility.
Significantly higher levels of prostaglandin E2 and vascular endothelial growth factor were associated with the severity of endometriosis. In this study, pathologic concentrations of prostaglandin E2 and vascular endothelial growth factor found in endometriotic women significantly inhibited sperm motility, acrosome reaction, and sperm-oocyte interaction, which might result in endometriosis-associated subfertility/infertility.
Lee
Te-Ching
TC
Institute of Physiological and Anatomical Medicine, Department of Anatomy, Tzu Chi University, and Department of Obstetrics and Gynecology, Yuli Veterans Hospital, Hualien, Taiwan.
Ho
Han-Chen
HC
D020101:Acrosome Reaction / Q000187:drug effects / Q000502:physiology; D000818:Animals; D006224:Cricetinae; D015232:Dinoprostone / Q000378:metabolism* / Q000494:pharmacology; D004715:Endometriosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007247:Infertility, Female / Q000503:physiopathology*; D008297:Male; D018919:Neovascularization, Physiologic / Q000502:physiology; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology*; D013084:Sperm-Ovum Interactions / Q000187:drug effects / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism* / Q000494:pharmacology
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D015232:Dinoprostone