title: Performance of multidetector computed tomographic angiography in determining surgical resectability of pancreatic head adenocarcinoma.
abstract: OBJECTIVE
  To evaluate the performance of multidetector computed tomographic angiography (MDCTA) in assessing the surgical resectability of pancreatic head adenocarcinoma.
  
  
  METHODS
  With institutional review board approval, radiographic, surgical, and pathological records of 203 consecutive patients with adenocarcinoma of the pancreatic head were analyzed retrospectively. Patients were imaged with MDCT scanners using our institution's CTA pancreatic protocol. Images were compared with surgical outcomes to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of MDCTA in determining resectability.
  
  
  RESULTS
  Data were analyzed twice, once with equivocal findings on MDCTA assumed as resectable and again with equivocal cases assumed as unresectable. All equivocal cases were ultimately unresectable; when this was assumed, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were determined to be 100%, 71%, 85%,100% and 89%. Twelve patients deemed resectable by preoperative MDCTA were found to be unresectable on surgical exploration owing to vascular involvement (n = 4), liver metastases (n = 4), and peritoneal involvement (n = 4).
  
  
  CONCLUSIONS
  Multidetector CT angiography offers accurate and valuable preoperative assessment of surgical resectability of pancreatic ductal adenocarcinoma. Liver and peritoneal metastases and vascular invasion still remain important pitfalls in preoperative evaluation.
authors.affiliation: Department of Radiological Science, University of California-Los Angeles, Los Angeles, CA 90095-7437, USA. okaneko@ucla.edu
authors.forename: Osamu F
authors.initials: OF
authors.lastname: Kaneko
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Lee
authors.forename: Jimmie
authors.initials: J
authors.lastname: Wong
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Kadell
authors.forename: Howard A
authors.initials: HA
authors.lastname: Reber
authors.forename: David S K
authors.initials: DS
authors.lastname: Lu
authors.forename: Steven S
authors.initials: SS
authors.lastname: Raman
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D018579:Patient Selection; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007472:Iohexol