title: Fasciculation and defasciculation of neurite bundles on micropatterned substrates.
abstract: We describe experiments of fasciculation, i.e., bundling, of chick sensory neurites on 2D striped substrates. By Fourier decomposition, we separate left-going and right-going neurite components from in vitro images, and we find first that neurite bundles orient toward preferred angles with respect to the stripe direction, and second that in vitro bundles travel in leftward and rightward directions nearly uninterrupted by crossings of bundles traveling in the opposing direction. We explore mechanisms that lead to these behaviors, and summarize implications for future models for neurite outgrowth and guidance.
authors.affiliation: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA. avoyiad@eden.rutgers.edu
authors.forename: A G
authors.initials: AG
authors.lastname: Voyiadjis
authors.forename: M
authors.initials: M
authors.lastname: Doumi
authors.forename: E
authors.initials: E
authors.lastname: Curcio
authors.forename: T
authors.initials: T
authors.lastname: Shinbrot
mesh_terms: D000818:Animals; D049108:Cell Enlargement; D002642:Chick Embryo / Q000166:cytology* / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D016501:Neurites / Q000502:physiology* / Q000648:ultrastructure*