Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review).
Cells are tightly regulated by sophisticated systems. Among such systems, post-translational modification has been intensively studied, and the ubiquitin-proteasome system is one of the best-known proteolytic mechanisms for the timely destruction of regulatory proteins. As progress has been made in research on the ubiquitin-proteasome system, our understanding of fundamental regulatory circuits, such as the cell cycle and circadian rhythms, has progressed. Here, we focused on the SKP1-CUL1-F-box protein of E3 ubiquitin ligase, especially the F-box and additional characteristic domain-containing proteins, as adaptors for regulatory proteins. Accumulating evidence suggests that the F-box and additional characteristic domain-containing proteins are involved in a wide variety of cellular processes and pathogenesis. This raises the possibility that F-box and additional characteristic domain-containing proteins could be used as biomarkers for certain diseases.
Sato
Kazuyuki
K
Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan.
Yoshida
Kenichi
K
D000818:Animals; D044783:F-Box Proteins / Q000502:physiology*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000502:physiology
D044783:F-Box Proteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex