Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent.
In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4 ± 2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.
Park
Jae Jun
JJ
Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706, Republic of Korea.
Lee
Tae Sup
TS
Kang
Joo Hyun
JH
Song
Rita
R
Cheon
Gi Jeong
GJ
D000818:Animals; D005260:Female; D007457:Iodine Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D045663:Quantum Dots; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013388:Succinimides / Q000737:chemistry*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013388:Succinimides; C022581:Bolton-Hunter reagent