Effect of long term low-fat dietary intervention on change in hemostatic factors: results from the Women's Health Initiative.
Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women's Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50-79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5%) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.
Rajpathak
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Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. swapnil.rajpathak@einstein.yu.edu
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Wassertheil-Smoller
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Van Horn
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Snetselaar
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Martin
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Rohan
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D000368:Aged; D018752:Diet, Fat-Restricted; D005167:Factor VII / Q000032:analysis*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006706:Homeostasis; D006801:Humans; D008875:Middle Aged; D016387:Women's Health
D005167:Factor VII; D005340:Fibrinogen