title: Weight-bearing asymmetry in relation to measures of impairment and functional mobility for people with knee osteoarthritis.
abstract: OBJECTIVE
  To compare weight-bearing asymmetry (WBA) for people with unilateral knee osteoarthritis (OA) with that for healthy adults of similar age. In addition, associations between WBA and clinical measures of knee impairment and functional mobility were evaluated.
  
  
  METHODS
  Cross-sectional design with age-matched control (CTL) group.
  
  
  METHODS
  Clinical research laboratory.
  
  
  METHODS
  People with end-stage unilateral knee OA (n=50) (OA group) and healthy people (n=17) (CTL group) were enrolled in the study (N=67).
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  WBA during a Five Times Sit-to-Stand Test (FTSST) based on average vertical ground reaction force under each foot, self-reported knee pain assessed using a Numerical Pain Rating Scale, knee extensor strength asymmetry based on peak isometric knee extension torque, knee motion asymmetry based on maximum passive knee extension and flexion angles, FTSST time, six-minute walk test distance, and Stair Climbing Test time.
  
  
  RESULTS
  The OA group demonstrated greater WBA than the CTL group during transitions between sitting and standing as measured by an absolute symmetry index (P=.015). No correlation was found between WBA and knee motion asymmetry, but comparisons of WBA with all the other outcome variables indicated fair relationships (range, r=.29-.44).
  
  
  CONCLUSIONS
  Weight-bearing asymmetry during transitions between sitting and standing can serve as a clinically relevant measure related to both knee impairment and functional mobility for people with unilateral knee OA.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Colorado Denver, Aurora, 80045, USA. cory.christiansen@ucdenver.edu
authors.forename: Cory L
authors.initials: CL
authors.lastname: Christiansen
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Stevens-Lapsley
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000503:physiopathology* / Q000534:rehabilitation; D010146:Pain / Q000209:etiology; D026741:Physical Therapy Modalities; D016059:Range of Motion, Articular; D016474:Weight-Bearing