title: A comparative biomechanical evaluation of hernia mesh fixation by fibrin sealant.
abstract: BACKGROUND
  The atraumatic fixation of meshes by fibrin sealant (FS) has been established for both open and laparoscopic techniques of hernia repair. This study was performed to evaluate the use of FS in hernia mesh fixation with different polymerization speed (thrombin concentrations), using commercial hernia meshes, and in two techniques, transabdominal preperitoneal mesh placement (TAPP) and intraperitoneal mesh placement (IPOM).
  
  
  METHODS
  A median laparotomy was performed in a pig model and hernia meshes were placed in IPOM and TAPP techniques. After mesh fixation with FS using thrombin concentrations of 4 and 500 IU/mL, maximum shear force before failure was measured at 5, 60, and 120 min.
  
  
  RESULTS
  At both thrombin concentrations and in all meshes in which the technique was used, the TAPP method tended to show higher maximum force levels at failure than did the IPOM method. In both TAPP and IPOM techniques and in all meshes, the 4 IU/mL thrombin concentration FS was superior to the 500 IU/mL thrombin concentration sealant.
  
  
  CONCLUSIONS
  Although both thrombin concentrations are suitable for mesh fixation, lower concentrations allow slower polymerization and better sealant diffusion leading to higher maximum force levels at failure. The TAPP method was biomechanically superior to the IPOM method. There were no major differences between mesh products.
authors.affiliation: Department of Surgery, Wilhelminenspital, Vienna, Austria.
authors.forename: René H
authors.initials: RH
authors.lastname: Fortelny
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Petter-Puchner
authors.forename: James
authors.initials: J
authors.lastname: Ferguson
authors.forename: Simone
authors.initials: S
authors.lastname: Gruber-Blum
authors.forename: Julian
authors.initials: J
authors.lastname: Brand
authors.forename: Kathrin
authors.initials: K
authors.lastname: Mika
authors.forename: Heinz
authors.initials: H
authors.lastname: Redl
mesh_terms: D034861:Abdominal Wall / Q000601:surgery; D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology; D046449:Hernia, Abdominal / Q000503:physiopathology* / Q000601:surgery*; D007813:Laparotomy / Q000379:methods; D010537:Peritoneum / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control; D013524:Surgical Flaps; D013526:Surgical Mesh; D034421:Sus scrofa; D013917:Thrombin / Q000494:pharmacology; D014014:Tissue Adhesives / Q000494:pharmacology*
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D014014:Tissue Adhesives; D013917:Thrombin