First report on fertility after allogeneic uterus transplantation.
Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.
Díaz-García
César
C
Department of Obstetrics and Gynecology, University of Gothenburg, Sweden. diaz_cesgar@gva.es
Akhi
Shamima N
SN
Wallin
Ann
A
Pellicer
Antonio
A
Brännström
Mats
M
D000818:Animals; D005260:Female; D005298:Fertility; D006084:Graft Rejection / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D016559:Tacrolimus / Q000494:pharmacology; D014184:Transplantation, Homologous; D014599:Uterus / Q000637:transplantation*
D007166:Immunosuppressive Agents; D016559:Tacrolimus