title: The aging kidney: structural changes.
abstract: A number of structural changes occur in the kidney with aging. The aging kidney is characterized by loss of renal mass, arterial sclerosis, arteriolar hyalinosis, an increased number of sclerotic glomeruli, loss of tubules and interstitial fibrosis. The pathogenesis of aging-associated structural changes is not completely understood. Both genetic background and hemodynamic factors have been associated with progression of age-related morphological changes. The structural changes of aging kidney are nonspecific and can be seen in many conditions, including diabetes and hypertension, and, as such, arterionephrosclerosis of aging is a diagnosis of exclusion.
authors.affiliation: "Bonomo" Hospital, Andria, Italy. g.pannarale@libero.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pannarale
authors.forename: Raffaella
authors.initials: R
authors.lastname: Carbone
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Del Mastro
authors.forename: Carmela
authors.initials: C
authors.lastname: Gallo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Gattullo
authors.forename: Luigi
authors.initials: L
authors.lastname: Natalicchio
authors.forename: Antonino
authors.initials: A
authors.lastname: Navarra
authors.forename: Agostino
authors.initials: A
authors.lastname: Tedesco
mesh_terms: D000367:Age Factors; D000375:Aging / Q000473:pathology*; D000818:Animals; D016922:Cellular Senescence; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000473:pathology / Q000503:physiopathology; D007684:Kidney Tubules / Q000473:pathology / Q000503:physiopathology; D012077:Renal Artery / Q000473:pathology / Q000503:physiopathology; D012079:Renal Circulation; D012307:Risk Factors