title: Human vascular aging: limb-specific lessons.
abstract: Unlike quadrupeds, human limbs are exposed to differing homeostatic challenges and uses across the life span. This raises the question of whether vascular function and skeletal muscle blood flow regulation differs between human limbs and whether these limb-specific parameters may be altered during exercise as a consequence of aging and disease.
authors.affiliation: Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, University of Utah, Salt Lake City, UT 84148, USA.
authors.forename: D Walter
authors.initials: DW
authors.lastname: Wray
authors.forename: Steve K
authors.initials: SK
authors.lastname: Nishiyama
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Donato
authors.forename: Russell S
authors.initials: RS
authors.lastname: Richardson
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005121:Extremities / Q000098:blood supply*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D012737:Sex Factors