title: Heterotopic ossifications after vertebroplasty using calcium phosphate in osteoporotic vertebral compression fractures: Report of 2 cases.
abstract: BACKGROUND
  Recently, calcium phosphate (CaP) cement, instead of polymethylmethacrylate, has been injected into the compressed vertebral body. Calcium phosphate may have the potential for ectopic or heterotopic ossification and, thus, injected CaP cement can induce unwanted heterotopic ossifications in the human body.
  
  
  METHODS
  The authors describe 2 cases of heterotopic ossifications after vertebroplasty using CaP in osteoporotic vertebral compression fractures. We performed percutaneous vertebroplasty using CaP cement in a 69-year-old woman with L2 compression fracture and an 80-year-old man with L1 compression fracture. Follow-up radiologic studies for both cases showed that heterotopic ossifications had developed around the CaP-augmented vertebral bodies and that the cemented vertebral bodies had recollapsed. Also, subsequent vertebral compression fractures had occurred.
  
  
  CONCLUSIONS
  We suggest that heterotopic ossification may be complications of vertebroplasty with CaP. Therefore, we strongly recommended that the patients who undergo a vertebroplasty with CaP need strict observation.
authors.affiliation: Department of Neurosurgery, Chunchon Sacred Heart Hospital, Hallym University College of Medicine, Chunchon-shi, Kangwon-do, South Korea. youmans@empal.com
authors.forename: Dong Hwa
authors.initials: DH
authors.lastname: Heo
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Cho
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Cho
authors.forename: Jun Hyeung
authors.initials: JH
authors.lastname: Cho
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Sheen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002130:Calcium Phosphates / Q000009:adverse effects*; D005260:Female; D050815:Fractures, Compression / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries; D008297:Male; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D010024:Osteoporosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D016103:Spinal Fractures / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D054854:Vertebroplasty / Q000009:adverse effects*
chemical_list: D002130:Calcium Phosphates; C020243:calcium phosphate