title: Evolution models with lethal mutations on symmetric or random fitness landscapes.
abstract: We calculate the mean fitness for evolution models, when the fitness is a function of the Hamming distance from a reference sequence, and there is a probability that this fitness is nullified (Eigen model case) or tends to the negative infinity (Crow-Kimura model case). We calculate the mean fitness of these models. The mean fitness is calculated also for the random fitnesses with logarithmic-normal distribution, reasonably describing sometimes the situation with RNA viruses.
authors.affiliation: Yerevan Physics Institute, Alikhanian Brothers Street 2, Yerevan 375036, Armenia.
authors.forename: Zara
authors.initials: Z
authors.lastname: Kirakosyan
authors.forename: David B
authors.initials: DB
authors.lastname: Saakian
authors.forename: Chin-Kun
authors.initials: CK
authors.lastname: Hu
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation / Q000235:genetics*; D016019:Survival Analysis; D015996:Survival Rate