title: Use of the molecular precursor method to facilitate thin hydroxyapatite coating of titanium fiber web scaffold and enhance bone formation: an experimental study in rat cranial bone defects.
abstract: OBJECTIVE
  This study evaluated the bone-regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method.
  
  
  METHODS
  TW disks with or without the thin HA coating were implanted into rat cranial bone defects. The rats were sacrificed after 3 or 6 weeks. New bone formation into the TW was evaluated.
  
  
  RESULTS
  The porous structure of TW was clearly maintained after the HA coating was applied. In the HA-coated TW group, new woven bone was observed in the majority of the disks after 6 weeks, whereas the control (uncoated TW) group showed limited new bone formation in the interior. The bone formation ratio in the HA-coated group was significantly higher than in the control group (20.6% and 59.1% after 3 and 6 weeks, respectively, versus 2.0% and 15.5%, respectively; P < .05).
  
  
  CONCLUSIONS
  The molecular precursor method of applying a thin HA coating to TW appeared to effectively enhance new bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW three-dimensional scaffold.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University, 3-9 Fuku-ura, Kanazawa-ku, Yokohama, Japan. mhirota@med.yokohama-cu.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirota
authors.forename: Tohru
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ametani
authors.forename: Yuka
authors.initials: Y
authors.lastname: Monden
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Noishiki
authors.forename: Iwai
authors.initials: I
authors.lastname: Tohnai
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D008297:Male; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000601:surgery; D013526:Surgical Mesh; D054457:Tissue Scaffolds; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; C101914:titanium fiber; D017886:Durapatite; D014025:Titanium