Novel vesicles self-assembled from amphiphilic star-armed PEG/polypeptide hybrid copolymers for drug delivery.
A novel amphiphilic four-armed [poly(ε-benzyloxycarbonyl-L-lysine)]₂-block-poly(ethylene glycol)-block-[poly(ε-benzyloxycarbonyl-L-lysine)]₂ hybrid copolymer has been prepared. The cytotoxicity study shows that the copolymer has good biocompatibility with no obvious inhibition effect on cell growth. The amphiphilic copolymers could self-assemble to form vesicles in aqueous solution. DOX · HCl, as a hydrophilic drug, can be loaded into the vesicles, and then successfully internalized by human breast cancer MCF-7 cells. Importantly, the DOX-loaded vesicles show a greatly improved drug release behavior with a zero-order release at the initial stage, suggesting a great potential as the carrier of hydrophilic drugs for controlled drug delivery.
Wang
Kang
K
The Institute for Advanced Materials and Nano Biomedicine (iNANO), Tongji University, Shanghai 200092, China.
Dong
Hai-Qing
HQ
Wen
Hui-Yun
HY
Xu
Meng
M
Li
Cao
C
Li
Yong-Yong
YY
Jones
Helen N
HN
Shi
Dong-Lu
DL
Zhang
Xian-Zheng
XZ
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008856:Microscopy, Fluorescence; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D014407:Tumor Cells, Cultured
C558159:(poly(epsilon-benzyloxycarbonyllysine))2-block-poly(ethylene glycol)-block-(poly(epsilon-benzyloxycarbonyllysine))2; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008823:Micelles; D011107:Polylysine; C038295:poly(N(epsilon)-benzyloxycarbonyl-L-lysine); D011092:Polyethylene Glycols; D004317:Doxorubicin