title: Temporal diffeomorphic free-form deformation for strain quantification in 3D-US images.
abstract: This paper presents a new diffeomorphic temporal registration algorithm and its application to motion and strain quantification from a temporal sequence of 3D images. The displacement field is computed by forward eulerian integration of a non-stationary velocity field. The originality of our approach resides in enforcing time consistency by representing the velocity field as a sum of continuous spatiotemporal B-Spline kernels. The accuracy of the developed diffeomorphic technique was first compared to a simple pairwise strategy on synthetic US images with known ground truth motion and with several noise levels, being the proposed algorithm more robust to noise than the pairwise case. Our algorithm was then applied to a database of cardiac 3D+t Ultrasound (US) images of the left ventricle acquired from eight healthy volunteers and three Cardiac Resynchronization Therapy (CRT) patients. On healthy cases, the measured regional strain curves provided uniform strain patterns over all myocardial segments in accordance with clinical literature. On CRT patients, the obtained normalization of the strain pattern after CRT agreed with clinical outcome for the three cases.
authors.affiliation: Center for Computational Imaging & Simulation Technologies in Biomedicine, Information and Communication Technologies Department, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Mathieu
authors.initials: M
authors.lastname: De Craene
authors.forename: Gemma
authors.initials: G
authors.lastname: Piella
authors.forename: Nicolas
authors.initials: N
authors.lastname: Duchateau
authors.forename: Etel
authors.initials: E
authors.lastname: Silva
authors.forename: Adelina
authors.initials: A
authors.lastname: Doltra
authors.forename: Hang
authors.initials: H
authors.lastname: Gao
authors.forename: Jan
authors.initials: J
authors.lastname: D'hooge
authors.forename: Oscar
authors.initials: O
authors.lastname: Camara
authors.forename: Josep
authors.initials: J
authors.lastname: Brugada
authors.forename: Marta
authors.initials: M
authors.lastname: Sitges
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Frangi
mesh_terms: D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity