New guaiane sesquiterpene lactones from Ixeris dentata.
Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-12,6 α-olide (1), ixerin N 6'- O-acetate (2), ixerisoside A 6'- O-acetate (3), ixerin N ( 4), ixerisoside A (5), ixerin M (6), tectroside (7), 8-epidesacylcynaropicrin glucoside (8), 8-epiisolipidiol (9), 11 βH-11,13-dihydrointegrifolin (10) 8 β-hydroxy-4 β,15-dihydrozaluzanin C (11), and integrifolin (12). Compounds 1-12 were evaluated for their inhibitory effect on the proliferation of the cultured human tumor cell lines MES-SA, MES-SA/DX5, HCT-15, and HCT15/CL02 in vitro.
Cha
Mi-Ran
MR
Korea Research Institute of Chemical Technology, Daejeon, Korea.
Choi
Yeon Hee
YH
Choi
Chun Whan
CW
Yoo
Dae Seok
DS
Kim
Young Sup
YS
Choi
Sang Un
SU
Kim
Young Ho
YH
Ryu
Shi Yong
SY
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C562104:3beta,8beta-dihydroxy-guaia-10(14)-en-1alpha,4alpha,5alpha,6beta,7alpha,11betaH-12,6alpha-olide; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C562106:ixerin N 6'- O-acetate; C562105:ixerisoside A