title: Ibuprofen induces reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA uptake in severe epithelial breast hyperplasia without atypia.
abstract: The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m-pentavalent dimercaptosuccinic acid (99mTc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia. Eight patients with histologically confirmed severe epithelial breast hyperplasia with (n  =  4) and without atypia (n  =  4) were submitted prospectively to 99mTc-(V)DMSA scintimammography before and after a 4-week course of 400 mg ibuprofen daily oral intake. Lesion to background ratios 60 minutes postinjection were calculated and compared (t-test) before and after ibuprofen administration. Prior to ibuprofen, the patients with severe epithelial hyperplasia displayed a significantly higher 99mTc-(V)DMSA uptake ratio compared to those with atypical epithelial hyperplasia (2.40 ± 0.32 vs 1.67 ± 0.09, respectively; p  =  .003). They also exhibited a more substantial percent decline in tracer uptake postibuprofen compared to women with atypical epithelial hyperplasia (62.0 ± 7.1 vs 15.0 ± 0.2, respectively; p  =  .001). Ibuprofen induces significant uptake reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA in severe epithelial breast hyperplasia without atypia. This agent could therefore constitute a potential imaging tool for monitoring chemoprophylaxis effectiveness in women at the early stages of malignant transformation.
authors.affiliation: Nuclear Medicine Department, "Alexandra" University Hospital, 80 Vassilisis Sophias' Avenue, Athens 11528, Greece. vpapantoniou@gmail.com
authors.forename: Vassilios
authors.initials: V
authors.lastname: Papantoniou
authors.forename: Angeliki
authors.initials: A
authors.lastname: Tsaroucha
authors.forename: Pipitsa
authors.initials: P
authors.lastname: Valsamaki
authors.forename: Spyridon
authors.initials: S
authors.lastname: Tsiouris
authors.forename: Evangelia
authors.initials: E
authors.lastname: Sotiropoulou
authors.forename: Theodore
authors.initials: T
authors.lastname: Karianos
authors.forename: Spyridon
authors.initials: S
authors.lastname: Marinopoulos
authors.forename: Athina
authors.initials: A
authors.lastname: Fothiadaki
authors.forename: Maria
authors.initials: M
authors.lastname: Sotiropoulou
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Archontaki
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Syrgiannis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Dimitrakakis
authors.forename: Aris
authors.initials: A
authors.lastname: Antsaklis
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism* / Q000473:pathology*; D007052:Ibuprofen / Q000378:metabolism*; D008327:Mammography; D008875:Middle Aged; D011446:Prospective Studies; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D007052:Ibuprofen