[Studies on relationship between myc family oncogene overexpression and prognosis of lung cancer.].
BACKGROUND
To evaluate the relationship between myc family oncogene overexpression and the clinical prognosis of lung cancer.


METHODS
A series of 47 primary lung cancer specimens was analyzed for myc family oncogenes by RT-PCR nondenature polycrylamide gel electrophoresis.


RESULTS
There was a positive correlation between overexpression of myc oncogenes and tumor size ,lymph node metastasis and stages of lung cancer. 18 of 24 patients (75%) with myc overexpression showed relapse , which was higher than that (47%) without myc gene overexpression for one year postoperatively. The results also showed that 19 of 27 cases (70%) with myc gene overexpression had p53 alteration , and that 63% and 76% of these 19 cases was in stage III and relapsed respectively , which was higher than that (27% and 22%) of the patients with p53 alteration but no myc gene overexpression.


CONCLUSIONS
myc family gene overexpression may be regarded as one of the prognostic determinants in lung cancer.
Bai
L
L
Chinese PLA General Hospital & Military Post-graduate Medical School, Beijing 100853, P.R.China.
Sun
Y
Y
Li
S
S