Estimates of interethnic admixture in the Brazilian population using a panel of 24 X-linked insertion/deletion markers.
OBJECTIVE
In this study, we aimed to identify ancestry informative haplotypes and make interethnic admixture estimates using X-chromosome markers.


METHODS
A significant sample (461 individuals) of European, African, and Native American populations was analyzed, and four linkage groups were identified. The data obtained were used to describe the ancestral contribution of populations from four different geographical regions of Brazil (745 individuals).


RESULTS
The global interethnic admixture estimates of the four mixed populations under investigation were calculated applying all the 24 insertion/deletion (INDEL) markers. In the North region, a larger Native Americans ancestry was observed (42%). The Northeast and Southeast regions had smaller Native American contribution (27% in both of them). In the South region, there was a large European contribution (46%).


CONCLUSIONS
The estimates obtained are compatible with expectations for a colonization model with biased admixture between European men (one X chromosome) and Native American and African women (two X chromosomes), so the 24 X-INDEL panel described here can be a useful to make admixture interethnic estimates in Brazilian populations.
Resque
Rafael Lima
RL
Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Para, Brazil.
Freitas
Natalle Do Socorro Da Costa
Ndo S
Rodrigues
Elzemar Martins Ribeiro
EM
Guerreiro
João Farias
JF
Santos
Ney Pereira Carneiro Dos
NP
Ribeiro dos Santos
Andrea
A
Zago
Marco Antonio
MA
Santos
Sidney
S
D001938:Brazil / Q000453:epidemiology; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D051456:Gene Flow; D005787:Gene Frequency; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D044469:Racial Groups
D005819:Genetic Markers