Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus.
OBJECTIVE
To determine the possible effect of corneal collagen crosslinking (CXL) with riboflavin and ultraviolet A (UVA) on intraocular pressure (IOP) measurements by Goldmann applanation tonometry (GAT).


METHODS
Institute of Vision and Optics, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.


METHODS
Prospective case series.


METHODS
This noncomparative study measured IOP by GAT before CXL and 6 months and 12 months after CXL.


RESULTS
The study evaluated 55 eyes (55 patients). There was a statistically significant increase in the measured IOP 6 months and 12 months after CXL (both P<.001). The mean measured IOP was 9.95 mm Hg ± 3.01 (SD) before CXL, 11.40 ± 2.89 mm Hg at 6 months, and 11.35 ± 3.38 mm Hg at 12 months. The change in IOP measurements at both postoperative examinations was not correlated with patient age, preoperative pachymetry, or preoperative keratometry readings.


CONCLUSIONS
After riboflavin-UVA CXL in eyes with keratoconus, there was a significant increase in IOP measured by GAT that was probably caused by an increase in corneal rigidity.
Kymionis
George D
GD
Institute of Vision and Optics, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
Grentzelos
Michael A
MA
Kounis
George A
GA
Portaliou
Dimitra M
DM
Detorakis
Efstathios T
ET
Magarakis
Michael
M
Karampatakis
Vasileios E
VE
Pallikaris
Ioannis G
IG
D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism*; D003432:Cross-Linking Reagents; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011446:Prospective Studies; D012256:Riboflavin / Q000627:therapeutic use*; D013997:Time Factors; D014065:Tonometry, Ocular; D014466:Ultraviolet Rays; D055815:Young Adult
D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin