Detection of low-level PTFE contamination: An application of solid-state NMR to structure elucidation in the pharmaceutical industry.
We report a novel use of solid-state ¹⁹F nuclear magnetic resonance to detect and quantify polytetrafluoroethylene contamination from laboratory equipment, which due to low quantity (up to 1% w/w) and insolubility remained undetected by standard analytical techniques. Solid-state ¹⁹F NMR is shown to be highly sensitive to such fluoropolymers (detection limit 0.02% w/w), and is demonstrated as a useful analytical tool for structure elucidation of unknown solid materials.
Pham
Tran N
TN
Chemical Development, GlaxoSmithKline Plc, Gunnels Wood Road, Stevenage, Hertfordshire SG12NY, UK. tran.pham@gsk.com
Day
Caroline J
CJ
Edwards
Andrew J
AJ
Wood
Helen R
HR
Lynch
Ian R
IR
Watson
Simon A
SA
Bretonnet
Anne-Sophie Z
AS
Vogt
Frederick G
FG
D004304:Dosage Forms; D004340:Drug Contamination / Q000517:prevention & control*; D057230:Limit of Detection; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D011138:Polytetrafluoroethylene / Q000032:analysis / Q000737:chemistry
D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D011138:Polytetrafluoroethylene