Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.
Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio [OR] = 1.72, 95% confidence interval [CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio [HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese.
Wang
Fen
F
Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, China.
Shu
Chang
C
Jia
Longfei
L
Zuo
Xiumei
X
Zhang
Yongbiao
Y
Zhou
Aihong
A
Qin
Wei
W
Song
Haiqing
H
Wei
Cuibai
C
Zhang
Feng
F
Hong
Zhen
Z
Tang
Muni
M
Wang
Duen-Mei
DM
Jia
Jianping
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007339:Insulysin / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D007339:Insulysin