[Clinical significance of MDR1 and MDRP gene expression in patients with non-small cell lung cancer.].
BACKGROUND
To investigate the clinical significance of MDR1 andMDRP gene expression in patients with non-small cell lung cancer (NSCLC) .


METHODS
Using reverse transcription polymerase chain reaction (RT-PCR) technique , the expression of MDR1 and MDRP gene was determined in cancer and paracancerous tissues from 33 NSCLC patients.


RESULTS
Positive expression of MDR1 gene was 69.7% and 36.4% in lung cancer tissues and paracancerous tissues respectively , and a highly significant difference was observed between the two groups ( P < 0.01) . The expression levels of MDR1 mRNA were much higher than those in paracancerous tissues. The positivity rate of MDRP gene expression in cancer tissues was 63.6% , which was higher than 30.3% in paracancerous tissue. The gene expression levels in cancer tissues were also significantly higher than those in paracancerous tissues. The expression levels of MDR1 and MDRP in cancer tissues of the patients receiving pre-operative chemotherapy were remarkably higher than those of the patients not receiving chemotherapy ( P < 0.05) .


CONCLUSIONS
NSCLC had primary and acquired multidrug resistance. It was of important significance to detect MDR1 and MDRP gene expression in directing chemotherapy of lung carcinoma and in predicting prognosis.
Wang
Y
Y
Department of Thoracic Surgery , No. 252 Hospital of P. L . A , Baoding 071000 , P. R. China.
Wang
A
A
Chen
J
J
Zhao
Y
Y
Li
X
X
Zang
Y
Y
Zhang
G
G
Song
Y
Y