title: Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors.
abstract: Cytomegaloviruses (CMV) are ubiquitous, opportunistic DNA viruses that have mastered the art of immune evasion through their ability to mimic host proteins or to inhibit antiviral responses. The study of the host response against CMV infection has illuminated many facets of the complex interaction between host and pathogen. Here, we review evidence derived from the animal models and human studies that supports the central role played by innate immune receptors in the recognition of virus infection and their participation in the many layers of defense.
authors.affiliation: Department of Human Genetics and Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada.
authors.forename: Michal
authors.initials: M
authors.lastname: Pyzik
authors.forename: Eve-Marie
authors.initials: EM
authors.lastname: Gendron-Pontbriand
authors.forename: Nassima
authors.initials: N
authors.lastname: Fodil-Cornu
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Vidal
mesh_terms: D000818:Animals; D003587:Cytomegalovirus / Q000276:immunology* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D011971:Receptors, Immunologic / Q000276:immunology*
chemical_list: D011971:Receptors, Immunologic