title: Multivariate statistical analysis of deformation momenta relating anatomical shape to neuropsychological measures.
abstract: The purpose of this study is to characterize the neuroanatomical variations observed in neurological disorders such as dementia. We do a global statistical analysis of brain anatomy and identify the relevant shape deformation patterns that explain corresponding variations in clinical neuropsychological measures. The motivation is to model the inherent relation between anatomical shape and clinical measures and evaluate its statistical significance. We use Partial Least Squares for the multivariate statistical analysis of the deformation momenta under the Large Deformation Diffeomorphic framework. The statistical methodology extracts pertinent directions in the momenta space and the clinical response space in terms of latent variables. We report the results of this analysis on 313 subjects from the Mild Cognitive Impairment group in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
authors.affiliation: University of Utah, Salt Lake City, UT, USA. nikhil@cs.utah.edu
authors.forename: Nikhil
authors.initials: N
authors.lastname: Singh
authors.forename: P Thomas
authors.initials: PT
authors.lastname: Fletcher
authors.forename: J Samuel
authors.initials: JS
authors.lastname: Preston
authors.forename: Linh
authors.initials: L
authors.lastname: Ha
authors.forename: Richard
authors.initials: R
authors.lastname: King
authors.forename: J Stephen
authors.initials: JS
authors.lastname: Marron
authors.forename: Michael
authors.initials: M
authors.lastname: Wiener
authors.forename: Sarang
authors.initials: S
authors.lastname: Joshi
mesh_terms: D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic