title: Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.
abstract: Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.
authors.affiliation: Global Child Health Group, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands. job.calis@gmail.com
authors.forename: Job C J
authors.initials: JC
authors.lastname: Calis
authors.forename: Kamija S
authors.initials: KS
authors.lastname: Phiri
authors.forename: Raymond J W M
authors.initials: RJ
authors.lastname: Vet
authors.forename: Rob J
authors.initials: RJ
authors.lastname: de Haan
authors.forename: Francis
authors.initials: F
authors.lastname: Munthali
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kraaijenhagen
authors.forename: Paul J M
authors.initials: PJ
authors.lastname: Hulshof
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Brabin
authors.forename: Michaël
authors.initials: M
authors.lastname: Boele van Hensbroek
authors.forename: Imelda
authors.initials: I
authors.lastname: Bates
mesh_terms: D000740:Anemia / Q000276:immunology*; D001853:Bone Marrow / Q000821:virology*; D016022:Case-Control Studies; D002675:Child, Preschool; D004920:Erythropoiesis / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny