title: Epidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen.
abstract: Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response.
authors.affiliation: Departamento de Enfermagem, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.
authors.forename: Dorlene M C
authors.initials: DM
authors.lastname: Aquino
authors.forename: Arlene J M
authors.initials: AJ
authors.lastname: Caldas
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Miranda
authors.forename: Antonio A M
authors.initials: AA
authors.lastname: Silva
authors.forename: Manoel
authors.initials: M
authors.lastname: Barral-Netto
authors.forename: Aldina
authors.initials: A
authors.lastname: Barral
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D007891:Leishmania / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000276:immunology; D011576:Psychodidae / Q000276:immunology*
chemical_list: D000906:Antibodies; D000953:Antigens, Protozoan