title: Reliability of the noninvasive sequence methods to estimate baroreflex function using the paradigm of brain death.
abstract: BACKGROUND
  Various techniques have been developed to estimate spontaneous baroreflex sensitivity noninvasively. However, in the EuroBaVar study it has been shown that they yield differing results.
  
  
  OBJECTIVE
  To investigate the reliability of these methods further we compared the results of the most common sequence techniques. We used the paradigm of brain death with the absence of any baroreflex function.
  
  
  METHODS
  In a prospective study we recorded breathing pattern, ECG and continuous blood pressure in 10 consecutive brain dead subjects of a neurointensive care unit. EuroBaVar sequence techniques 12-18 (ST12-ST18) were applied to the data sets and the number of sequences compared.
  
  
  RESULTS
  Techniques which are based on thresholds in terms of blood pressure or R-R interval changes yielded the least false positive results: technique ST12, ST13, and ST14 detected very few sequences, while ST18 detected no sequence at all. Techniques using a correlation threshold (ST15-ST17) found a high number.
  
  
  CONCLUSIONS
  This study demonstrates clearly that many of the sequence techniques used to estimate baroreflex sensitivity render false positive results in the unique paradigm of brain death. Thus, the method should be selected with regard to the biological signal and the pathophysiological background.
authors.affiliation: Department for Neurology and Psychiatry, General Hospital of the City of Linz, Austria; Neurointensive Care Unit, Department for Neurology and Psychiatry, General Hospital of the City of Linz, Austria. Walter.Struhal@akh.linz.at
authors.forename: W
authors.initials: W
authors.lastname: Struhal
authors.forename: S
authors.initials: S
authors.lastname: Hoedl
authors.forename: H
authors.initials: H
authors.lastname: Lahrmann
authors.forename: E
authors.initials: E
authors.lastname: Toeglhofer
authors.forename: F
authors.initials: F
authors.lastname: Gruber
authors.forename: M
authors.initials: M
authors.lastname: Vosko
authors.forename: G
authors.initials: G
authors.lastname: Ransmayr
mesh_terms: D000293:Adolescent; D000328:Adult; D017704:Baroreflex; D001794:Blood Pressure; D001926:Brain Death / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D055815:Young Adult