title: Chronic intermittent hypoxia exposure induces memory impairment in growing rats.
abstract: The study was aimed to examine the effect of chronic intermittent hypoxia (CIH) on spatial memory of growing rats and to explore the possible underlying mechanisms. Sixty two rats were trained to perform the 8-arm radial maze task and were divided into four groups: 2-week-CIH (2IH) 2-week-control (2C) 4-week-CIH (4IH) and 4-week-control (4C). There were more reference memory errors, working memory errors and total memory errors in 2IH and 4IH groups compared to the controls. The levels of 8-iso-Prostaglandin F(2-alpha) [8-ISO-PGF(2-alpha)] an in vivo marker for oxidative stress, in serum, hippocampus and prefrontal cortex were higher in CIH groups than the control groups. There were significant correlations between the levels of 8-ISO-PGF(2-alpha) and numbers of memory errors. The ultrastructural changes were evident in the hippocampal and prefrontal cortical tissues from the CIH groups. These results indicate that CIH can induce oxidative stress in brain tissues involved in spatial memory function.
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical College, Wenzhou, China. caixh839@sina.com.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Cai
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Zhou
authors.forename: Cun-Xue
authors.initials: CX
authors.lastname: Zhang
authors.forename: Liang-Gang
authors.initials: LG
authors.lastname: Hu
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Fan
authors.forename: Chang-Chong
authors.initials: CC
authors.lastname: Li
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Zheng
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Gong
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000378:metabolism; D006624:Hippocampus / Q000648:ultrastructure; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000523:psychology*; D018384:Oxidative Stress / Q000502:physiology; D017397:Prefrontal Cortex / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D006861:Hydrogen Peroxide