Virtual mitochondrion: towards an integrated model of oxidative phosphorylation complexes and beyond.
The modelling of OXPHOS (oxidative phosphorylation) in order to integrate all kinetic and thermodynamic aspects of chemiosmotic theory has a long history. We briefly review this history and show how new ways of modelling are required to integrate a local model of the individual respiratory complexes into a global model of OXPHOS and, beyond that, into a reliable overall model of central metabolism.
Mazat
Jean-Pierre
JP
Université de Bordeaux 2, 146 rue Léo-Saignat, F 33076, Bordeaux Cedex, France. jpm@u-bordeaux2.fr
Fromentin
Jonathan
J
Heiske
Margit
M
Nazaret
Christine
C
Ransac
Stéphane
S
D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010085:Oxidative Phosphorylation