title: Eruptive microvenular hemangiomas in 4 Chinese patients: clinicopathologic correlation and review of the literature.
abstract: Microvenular hemangioma (MVH) is an uncommon benign vascular neoplasm that usually occurs as a solitary asymptomatic red or purple papule, nodule, or plaque with a predilection for the upper extremities. Patients with more than 1 lesion, that is, multiple MVHs, are extremely rare. We describe the clinicopathologic features of 4 Chinese patients who had a rapidly progressive abrupt onset of numerous MVHs numbering in the tens to hundreds. Clinically, the correct diagnosis of MVH could not be made in any of our patients; however, histologic examination revealed the characteristic features of MVH. Immunohistochemical stains were performed in all cases and showed the vessel lining cells to be positive for CD34, CD31, and factor VIII-related antigen. Polymerase chain reaction for human herpesvirus-8 was negative in all cases. The differential diagnosis and review of the literature of patients with multiple MVHs are presented.
authors.affiliation: Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China.
authors.forename: Xiu-Lian
authors.initials: XL
authors.lastname: Xu
authors.forename: Cui-Rong
authors.initials: CR
authors.lastname: Xu
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Yuan-Hua
authors.initials: YH
authors.lastname: Cao
authors.forename: Xue-Si
authors.initials: XS
authors.lastname: Zeng
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002681:China; D003937:Diagnosis, Differential; D005260:Female; D006391:Hemangioma / Q000276:immunology / Q000473:pathology* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000821:virology; D014699:Venules / Q000276:immunology / Q000473:pathology* / Q000821:virology; D055815:Young Adult; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor