Carbazoles and coumarins from Clausena harmandiana stimulate glucose uptake in L6 myotubes.
Two carbazoles (compounds 1 and 2) and one coumarin (compound 8) from Clausena harmandiana exhibited significant glucose uptake activity in L6 myotubes in a time and dose dependent manner. In addition, compounds 2 and 8 were inhibited by p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinases, respectively.
Noipha
Kusumarn
K
Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90110, Thailand.
Thongthoom
Tula
T
Songsiang
Uraiwan
U
Boonyarat
Chantana
C
Yenjai
Chavi
C
D002227:Carbazoles / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D054700:Clausena / Q000737:chemistry; D003374:Coumarins / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D003847:Deoxyglucose / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011725:Pyridines / Q000494:pharmacology; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors
D002227:Carbazoles; D003374:Coumarins; D007093:Imidazoles; D010936:Plant Extracts; D011725:Pyridines; D003571:Cytochalasin B; D003513:Cycloheximide; D003847:Deoxyglucose; D048051:p38 Mitogen-Activated Protein Kinases; C093642:SB 203580