title: Streptomyces coelicolor increases the production of undecylprodigiosin when interacted with Bacillus subtilis.
abstract: Undecylprodigiosin has antimicrobial, immunosuppressive and anticancer properties. Pure cultures of Streptomyces coelicolor produce only low concentrations of undecylprodigiosin. We have therefore sought to increase this by interacting the cells with a bacterium. When interacted with live or heat-killed cells of Bacillus subtilis, Streptomyces coelicolor A3 (2), increased undecylprodigiosin production in shake-flasks and in a 2 l bioreactor. An inoculum of 2.5% (v/v) B. subtilis containing 10(8) cells/ml added at the beginning of the S. coelicolor culture gave the best results for undecylprodigiosin production. In the shake-flasks, the increase was 175-211% and in the bioreactor, 256% in comparison to the pure cultures of S. coelicolor.
authors.affiliation: School of Chemical Engineering and Analytical Science, The Mill, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Khalid Jaber Kadhum
authors.initials: KJ
authors.lastname: Luti
authors.forename: Ferda
authors.initials: F
authors.lastname: Mavituna
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000898:Antibiosis; D001412:Bacillus subtilis / Q000502:physiology*; D001709:Biotechnology / Q000379:methods*; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; C047347:undecylprodigiosin; D011353:Prodigiosin