title: Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics.
abstract: Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.
authors.affiliation: Department of Gynecology and Obstetrics, University Clinic of Münster, Münster, Germany. Andreas.Schuering@ukmuenster.de
authors.forename: Andreas N
authors.initials: AN
authors.lastname: Schüring
authors.forename: Nicole
authors.initials: N
authors.lastname: Schulte
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kelsch
authors.forename: Albrecht
authors.initials: A
authors.lastname: Röpke
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kiesel
authors.forename: Martin
authors.initials: M
authors.lastname: Götte
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology*; D001706:Biopsy; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D002469:Cell Separation; D004717:Endometrium / Q000166:cytology*; D005260:Female; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology