title: Optimal mutation rates in dynamic environments: The Eigen model.
abstract: We consider the Eigen quasispecies model with a dynamic environment. For an environment with sharp-peak fitness in which the most-fit sequence moves by k spin-flips each period T we find an asymptotic stationary state in which the quasispecies population changes regularly according to the regular environmental change. From this stationary state we estimate the maximum and the minimum mutation rates for a quasispecies to survive under the changing environment and calculate the optimum mutation rate that maximizes the population growth. Interestingly we find that the optimum mutation rate in the Eigen model is lower than that in the Crow-Kimura model, and at their optimum mutation rates the corresponding mean fitness in the eigenmodel is lower than that in the Crow-Kimura model, suggesting that the mutation process which occurs in parallel to the replication process as in the Crow-Kimura model gives an adaptive advantage under changing environment.
authors.affiliation: Department of Physics, The Catholic University of Korea, Bucheon, Gyeonggi-do, Korea.
authors.forename: Mark
authors.initials: M
authors.lastname: Ancliff
authors.forename: Jeong-Man
authors.initials: JM
authors.lastname: Park