[Leukocyte nitric oxide status in patients with chronic recurrent furunculosis].
The basal and in vitro pyrogenal-stimulated nitric oxide-producing capabilities of leukocytes versus their oxygen-producing and phagocytic activity were studied in patients with chronic recurrent furunculosis during remission (n=62) and exacerbation (n=12). The basal nitric oxide-producing activity of leukocytes was found to be similar. The stimulated leukocyte cultures from the patients showed mainly a perverted reaction--suppression of nitric oxide production instead of its increase detectable in donors. A direct correlation was found between the nitric oxide-producing activity of leukocytes and the results of HCT test in healthy individuals and patients during exacerbation rather than remission.
Novikova
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Gomoliako
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D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002478:Cells, Cultured; D005260:Female; D005667:Furunculosis / Q000097:blood* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D010587:Phagocytosis / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012008:Recurrence; D013203:Staphylococcal Infections / Q000097:blood* / Q000378:metabolism / Q000382:microbiology; D013211:Staphylococcus aureus / Q000254:growth & development; D055815:Young Adult
D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; C009136:pyrogenal; D009569:Nitric Oxide