title: Non-rigid registration with missing correspondences in preoperative and postresection brain images.
abstract: Registration of preoperative and postresection images is often needed to evaluate the effectiveness of treatment. While several non-rigid registration methods exist, most would be unable to accurately align these types of datasets due to the absence of tissue in one image. Here we present a joint registration and segmentation algorithm which handles the missing correspondence problem. An intensity-based prior is used to aid in the segmentation of the resection region from voxels with valid correspondences in the two images. The problem is posed in a maximum a posteriori (MAP) framework and optimized using the expectation-maximization (EM) algorithm. Results on both synthetic and real data show our method improved image alignment compared to a traditional non-rigid registration algorithm as well as a method using a robust error kernel in the registration similarity metric.
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, USA. nicha.chitphakdithai@yale.edu
authors.forename: Nicha
authors.initials: N
authors.lastname: Chitphakdithai
authors.forename: James S
authors.initials: JS
authors.lastname: Duncan
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique