title: S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides.
abstract: The construction of a library of benzothiaoxazepine-1,1'-dioxides utilizing a one-pot, S(N)Ar diversification-ODCT(50) scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Rolfe
authors.forename: Thiwanka B
authors.initials: TB
authors.lastname: Samarakoon
authors.forename: Sarra V
authors.initials: SV
authors.lastname: Klimberg
authors.forename: Marek
authors.initials: M
authors.lastname: Brzozowski
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015394:Molecular Structure; D010077:Oxazepines / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D010077:Oxazepines; D010087:Oxides; D054852:Small Molecule Libraries; D013844:Thiazoles