title: In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: results of the COMPACT Asia-Pacific Study.
abstract: The Comparative Activity of Carbapenems Testing (COMPACT) Study was designed to determine the in vitro potency of doripenem compared with imipenem and meropenem against a large number of contemporary Gram-negative pathogens from more than 100 centres across Europe and the Asia-Pacific region and to assess the reliability of Etest methodology for doripenem minimum inhibitory concentration (MIC) determination against these pathogens. Data from eight countries within the Asia-Pacific region, which collected 1612 bacterial isolates, are presented here. Etest methodology was found to be a reliable method for MIC determination. Doripenem showed in vitro activity similar to or better than meropenem and at least four-fold better than imipenem against Enterobacteriaceae. Against Pseudomonas aeruginosa, doripenem was also the most active of the three carbapenems in vitro. However, in vitro results do not necessarily correlate with clinical outcome.
authors.affiliation: PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia.
authors.forename: K J
authors.initials: KJ
authors.lastname: Christiansen
authors.forename: M
authors.initials: M
authors.lastname: Ip
authors.forename: H B
authors.initials: HB
authors.lastname: Ker
authors.forename: M
authors.initials: M
authors.lastname: Mendoza
authors.forename: L
authors.initials: L
authors.lastname: Hsu
authors.forename: P
authors.initials: P
authors.lastname: Kiratisin
authors.forename: A
authors.initials: A
authors.lastname: Chongthaleong
authors.forename: I S
authors.initials: IS
authors.lastname: Redjeki
authors.forename: A
authors.initials: A
authors.lastname: Quintana
authors.forename: R
authors.initials: R
authors.lastname: Flamm
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: M
authors.initials: M
authors.lastname: Cassettari
authors.forename: D
authors.initials: D
authors.lastname: Cooper
authors.forename: P
authors.initials: P
authors.lastname: Okolo
authors.forename: I
authors.initials: I
authors.lastname: Morrissey
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010139:Pacific Islands; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D000077726:Doripenem; D000077731:Meropenem