title: (-)-α-Bisabolol attenuates visceral nociception and inflammation in mice.
abstract: The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (-)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent.
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil.
authors.forename: Gerlânia de O
authors.initials: Gde O
authors.lastname: Leite
authors.forename: Laura H I
authors.initials: LH
authors.lastname: Leite
authors.forename: Renata de S
authors.initials: Rde S
authors.lastname: Sampaio
authors.forename: Mariana Késsia A
authors.initials: MK
authors.lastname: Araruna
authors.forename: Irwin Rose A
authors.initials: IR
authors.lastname: de Menezes
authors.forename: José Galberto M
authors.initials: JG
authors.lastname: da Costa
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Campos
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced / Q000188:drug therapy*; D000208:Acute Disease; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D003106:Colon / Q000187:drug effects; D003520:Cyclophosphamide; D003872:Dermatitis / Q000188:drug therapy*; D004195:Disease Models, Animal; D004423:Ear; D008297:Male; D051379:Mice; D000081222:Monocyclic Sesquiterpenes; D009149:Mustard Plant; D009822:Oils, Volatile / Q000737:chemistry; D010537:Peritoneum / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010938:Plant Oils; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; D012717:Sesquiterpenes; C004497:bisabolol; D003520:Cyclophosphamide; C027793:mustard oil