title: Colonoscopic findings in coeliac disease on a gluten-free diet.
abstract: BACKGROUND
  to date, there are few data on colonoscopic findings in patients with celiac disease, and most of these obtained in patients with iron deficiency anaemia.
  
  
  OBJECTIVE
  we assessed colonoscopic findings in unselected patients with coeliac disease, since there are no studies available also considering morphological aspects, and there is literature suggestion of increased prevalence of colorectal tumours.
  
  
  METHODS
  colonoscopies with multiple biopsies were retrospectively analyzed in 42 coeliac disease patients on gluten-free diet above age 40; 16 had clinical or laboratory features of iron deficiency anaemia. Mucosal biopsies were evaluated for the presence of intraepithelial lymphocytes and of mucosal eosinophils, in addition to conventional histologic assessment, and compared with those obtained in 15 controls.
  
  
  RESULTS
  macroscopic abnormalities (polyps, diverticula, inflammatory changes) were found in 26% of patients. Microscopic abnormalities (lymphocytic colitis, melanosis coli, rectal histiocytosis) were found in 36% of patients. None of these findings was found in controls. Coeliac disease patients had significantly higher eosinophil score than controls in the right colon, whereas this was not significantly different between groups in the left colon.
  
  
  CONCLUSIONS
  colonoscopic findings in coeliac disease on gluten-free diet may reveal significant findings, even in patients without iron deficiency anaemia. There is the need of further studies in larger cohorts of patients to establish whether colonoscopy in these patients may be clinically useful.
authors.affiliation: Division of Internal Medicine, Desio General Hospital, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Casella
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: C
authors.initials: C
authors.lastname: Di-Bella
authors.forename: E
authors.initials: E
authors.lastname: de-Marco
authors.forename: F
authors.initials: F
authors.lastname: Pagni
authors.forename: E
authors.initials: E
authors.lastname: Drera
authors.forename: R
authors.initials: R
authors.lastname: Ortenzi
authors.forename: V
authors.initials: V
authors.lastname: Baldini
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
mesh_terms: D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000178:diet therapy* / Q000473:pathology*; D003113:Colonoscopy; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies