title: [Effect of omega-3 acids on clinical evolution, plasma inflammatory biomarkers and B-type natriuretic peptide levels in patients with coronary heart disease].
abstract: OBJECTIVE
  The consumption of fish has been associated with a minor risk of cardiovascular mortality.
  
  
  METHODS
  Thirty-one patients with clinical and angiographic evidence of coronary illness and no data of heart failure were followed up. One gram per day of omega-3-acid ethyl esters was added to their usual cardiologic treatment. Demographic, clinical and analytical data (lipid, ESR, CRP, lipoprotein[a], fibrinogen, and BNP levels) were evaluated at the beginning and at 9 months.
  
  
  RESULTS
  Six patients had cardiologic events in the follow up although none presented acute coronary syndrome. Significant differences were seen in HDL cholesterol (mg/dL) (38,5[9,6] vs. 42,1 (11,0), p=0,000), hemoglobin (g/dL) (13,2 [1,7] vs. 13,9 (1,7), p=0,009) and pro-BNP (pg/dL) (745,5 [1,035,7] vs. 235,8 [194,0], p=0,008) levels. No significant differences existed either in the inflammatory parameters or in total cholesterol, LDL cholesterol and triglycerides.
  
  
  CONCLUSIONS
  One gram day of omega-3-acid ethyl esters added to the usual cardiologic treatment in patients with coronary heart disease improves pro BNP levels of patients with preserved left ventricular function without modifying serum inflammatory parameters.
authors.affiliation: Servicio de Cardiología, Complejo Hospitalario Universitario Insular-Materno infantil, Las Palmas de Gran Canaria, Gran Canaria, España. efrenmartinezquintana@yahoo.es
authors.forename: Efrén
authors.initials: E
authors.lastname: Martínez-Quintana
authors.forename: Fayna
authors.initials: F
authors.lastname: Rodríguez-González
authors.forename: Estrella
authors.initials: E
authors.lastname: Torres-Fuentes
authors.forename: Laura
authors.initials: L
authors.lastname: López-Ríos
authors.forename: Vicente
authors.initials: V
authors.lastname: Nieto-Lago
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004334:Drug Administration Schedule; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D014280:Triglycerides; D020097:Natriuretic Peptide, Brain