Focused review: neuraxial morphine and oral herpes reactivation in the obstetric population.
Neuraxial morphine administration is a common strategy for providing postcesarean delivery analgesia. Morphine delivered via this route increases the risk of herpes labialis (oral herpes) reactivation, a disease common in women of childbearing age. A primary concern is risk of transmission to the neonate from maternal reactivation. The benefits to the mother of this form of analgesia outweigh the risk of neonatal herpes acquired postpartum from maternal recurrence because serious neonatal morbidity from recurrent herpes has not been described.
Bauchat
Jeanette R
JR
Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. jbauchat@gmail.com
D016362:Analgesia, Obstetrical / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D002585:Cesarean Section / Q000009:adverse effects; D005260:Female; D006560:Herpes Labialis / Q000139:chemically induced* / Q000635:transmission / Q000821:virology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D018139:Simplexvirus / Q000187:drug effects*; D014775:Virus Activation / Q000187:drug effects*
D000701:Analgesics, Opioid; D009020:Morphine