[Concentration of selected biochemical parameters in blood of pregnant women infected by HPV 16 and 18].
Asymptomatic HPV infection in pregnant women may be connected with changes of pro-inflammatory cytokines and proteolytic enzymes which may condition the persistence of infection during pregnancy.


OBJECTIVE
The main aim of the study was to evaluate the concentration of interleukin-1, TNF-alpha and alpha-1 antitrypsin in pregnant women infected by oncogenic types HPV.


METHODS
The study was conducted in 2008-2009 at the Department of Obstetrics and Gynecology Medical University Lodz, on pregnant women in the third trimester of pregnancy The study group consisted on 19 pregnant women HPV-16, -18 infected. The control group consisted on 34 pregnant women at the same gestational age, HPV-negative. The concentration of interleukin-1, TNF-alpha and alpha-1 antitripsin was estimated in blood.


RESULTS
The results of concentration interleukin-1, TNF-alpha and alpha-1 antitrypsin were similar in both groups of pregnant women.


CONCLUSIONS
High risk HPV infection has no influence on the concentration of pro- inflammatory cytokines. In HPV infection during pregnancy the anti proteolytic defense did not decrease.
Karowicz-Bilińska
Agata
A
Klinika Patologii Ciazy, I Katedra Ginekologii i Połoinictwa UM w Łodzi. agakar@interia.pl
Brzozowska
Maria
M
Estemberg
Dorota
D
Kuś
Ewa
E
Berner-Trabska
Marlena
M
Kowalska-Koprek
Urszula
U
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D052162:Human papillomavirus 16 / Q000378:metabolism*; D052161:Human papillomavirus 18 / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D030361:Papillomavirus Infections / Q000097:blood*; D011044:Poland; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult; D000515:alpha 1-Antitrypsin / Q000097:blood
D015415:Biomarkers; D016207:Cytokines; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D000515:alpha 1-Antitrypsin