[Pharmacological research of wild and cultivated Atractylodes lancea].
OBJECTIVE
To explore the differences of the main pharmacological action in wild and cultivated Atractylodes lancea.


METHODS
Study the effect of the 70% ethanol extracts from the wild and the culticated A. lancea on the mice with gastriculcer induced by absolute ethyl alcohol or HCl. Stdudy the effect on intestinal propulsive function in mice by measuring the length of intestine and distance of Indian ink. Observe anti-bacteria effect in vitro of the A. lancea by determining the minimum inhibitory concentrations.


RESULTS
The pharmacological action, which made a little difference in the sane productive places, and made significant differences in different productive places. Compared to Jurong, it has better actions in Luotian on small intestinal propulsive function and bacteriostatic action. There was not an obvious difference in protective effect on gastric ulcer induced by absolute ethyl alcohol and 0.6 mol x L(-1) HC1 between different locations.


CONCLUSIONS
To the main effect, cultvated A. lancea had no significant difference on the whole but having better result in some respects, which can provide the pharmacodynamics evidence of cultivated A. lancea being used instead of the wild.
Zhu
Donghai
D
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhudonghai2000@163.com
Fu
Meihong
M
Yang
Qing
Q
Fang
Jing
J
Song
Hongyue
H
Yang
Bin
B
Xiong
Yulan
Y
D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
D004365:Drugs, Chinese Herbal