title: Prolactin is involved in the systemic inflammatory response in myocardial infarction.
abstract: Prolactin may contribute to an atherogenic phenotype. Furthermore, previous studies have shown that prolactin levels increase in situations of acute stress and inflammation. We therefore aimed to investigate the relationship between prolactin, acute stress and inflammation in patients with myocardial infarction. We performed a case-control study in 40 patients with myocardial infarction and 39 controls, aged 41-84 years. Blood for assessment of prolactin and high sensitive C-reactive protein (hsCRP) was drawn at inclusion, that is, during the acute phase of the event, and 2-3 weeks later. Unexpectedly, prolactin levels at inclusion did not differ between cases and controls (7.0 ng/ml and 6.0 ng/ml, respectively, p=0.28). 2-3 weeks later prolactin levels in cases had not decreased. However, univariate regression analysis indicated that hsCRP is associated with prolactin levels (regression coefficient β 0.11; [95% CI 0.01; 0.21]; p=0.03) in cases during the acute phase of myocardial infarction. Our findings may suggest that prolactin is involved in the systemic inflammatory response, which takes place during myocardial infarction; however, this association may not be strong enough to induce higher prolactin levels in patients with myocardial infarction.
authors.affiliation: Department of Vascular Medicine of the Academic Medical Center, Amsterdam, The Netherlands. a.q.reuwer@amc.uva.nl
authors.forename: A Q
authors.initials: AQ
authors.lastname: Reuwer
authors.forename: B
authors.initials: B
authors.lastname: van Zaane
authors.forename: M
authors.initials: M
authors.lastname: van Wissen
authors.forename: A P
authors.initials: AP
authors.lastname: van Zanten
authors.forename: M T B
authors.initials: MT
authors.lastname: Twickler
authors.forename: V E A
authors.initials: VE
authors.lastname: Gerdes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology*; D011388:Prolactin / Q000276:immunology*
chemical_list: D011388:Prolactin; D002097:C-Reactive Protein