title: Nonlocal patch-based label fusion for hippocampus segmentation.
abstract: Quantitative magnetic resonance analysis often requires accurate, robust and reliable automatic extraction of anatomical structures. Recently, template-warping methods incorporating a label fusion strategy have demonstrated high accuracy in segmenting cerebral structures. In this study, we propose a novel patch-based method using expert segmentation priors to achieve this task. Inspired by recent work in image denoising, the proposed nonlocal patch-based label fusion produces accurate and robust segmentation. During our experiments, the hippocampi of 80 healthy subjects were segmented. The influence on segmentation accuracy of different parameters such as patch size or number of training subjects was also studied. Moreover, a comparison with an appearance-based method and a template-based method was carried out. The highest median kappa value obtained with the proposed method was 0.884, which is competitive compared with recently published methods.
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada.
authors.forename: Pierrick
authors.initials: P
authors.lastname: Coupé
authors.forename: José V
authors.initials: JV
authors.lastname: Manjón
authors.forename: Vladimir
authors.initials: V
authors.lastname: Fonov
authors.forename: Jens
authors.initials: J
authors.lastname: Pruessner
authors.forename: Montserrat
authors.initials: M
authors.lastname: Robles
authors.forename: D Louis
authors.initials: DL
authors.lastname: Collins
mesh_terms: D000465:Algorithms; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique