[Antitumor effect of tumor necrosis factor alpha and interferon gamma on human lung adenocarcinoma A549 cell line.].
BACKGROUND
To explore the synergistic antitumor effect of tumor necrosis factor alpha (TNF-alpha) and interferon gamma ( IFN-gamma) on human lung adenocarcinoma A549 cell line.


METHODS
Cell growth inhibition was determined byMTT colorimetry assay.


RESULTS
Both TNF-alpha and IFN-gamma showed directly growth inhibition on human lung carcinoma A549 cell line. IFN-gamma could enhance cell growth inhibition effect of TNF-alpha when used together.


CONCLUSIONS
TNF-alpha and IFN-gamma displayed significant synergistic antitumor effect on human lung adenocarcinoma A549 cell line. These results give experimental evidence for the multimodality therapy of human lung cancer and other tumors.
Jiang
Z
Z
Department of Respiratory Medicine , The First Affiliated Hospital of Nanjing Medical University , Nanjing 210029 , P. R. China.
Yu
W
W