title: Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models.
abstract: Identifying mild cognitive impairment (MCI) subjects who will convert to clinical Alzheimer's disease (AD) is important for therapeutic decisions, patient counselling and clinical trials. Hippocampal volume and rate of atrophy predict clinical decline at the MCI stage and progression to AD. In this paper, we create p-maps from the differences in the shape of the hippocampus between 60 normal controls and 60 AD subjects using statistical shape models, and generate different regions of interest (ROI) by thresholding the p-maps at different significance levels. We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs.
authors.affiliation: Centre for Medical Image Computing, University College London, WC1E 6BT, UK.
authors.forename: Kelvin K
authors.initials: KK
authors.lastname: Leung
authors.forename: Kai-Kai
authors.initials: KK
authors.lastname: Shen
authors.forename: Josephine
authors.initials: J
authors.lastname: Barnes
authors.forename: Gerard R
authors.initials: GR
authors.lastname: Ridgway
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Clarkson
authors.forename: Jurgen
authors.initials: J
authors.lastname: Fripp
authors.forename: Olivier
authors.initials: O
authors.lastname: Salvado
authors.forename: Fabrice
authors.initials: F
authors.lastname: Meriaudeau
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.forename: Pierrick
authors.initials: P
authors.lastname: Bourgeat
authors.forename: Sébastien
authors.initials: S
authors.lastname: Ourselin
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000209:etiology* / Q000473:pathology*; D001284:Atrophy / Q000150:complications / Q000473:pathology; D003072:Cognition Disorders / Q000150:complications* / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique