title: Highly organocatalytic asymmetric Michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles.
abstract: An efficient Michael-ketone aldol-dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Liang-Liang
authors.initials: LL
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Peng
authors.forename: Jian-Fei
authors.initials: JF
authors.lastname: Bai
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Huang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Xu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D007211:Indoles; D007659:Ketones; D014867:Water