title: Comparison of wound strength with and without a hydrogel liquid ocular bandage in human cadaver eyes.
abstract: OBJECTIVE
  To determine whether a hydrogel liquid ocular bandage improves wound strength.
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  Laboratory investigation.
  
  
  METHODS
  The wound strength of 2.8 mm clear corneal incisions and 23-gauge scleral incisions was tested in cadaver eyes by raising the intraocular pressure (IOP) until leakage occurred. The pressure at the first sign of incision leakage with the liquid bandage and without the liquid bandage was determined.
  
  
  RESULTS
  Four corneal incisions and 4 scleral incisions were made in 5 cadaver eyes. The mean pressure at the first sign of corneal incision leakage was 59.5 mm Hg ± 21.0 (SD) without the liquid bandage and 198.1 ± 57.6 mm Hg with the liquid bandage (P<.0001). The mean pressure at the first sign of scleral incision leakage was 47.9 ± 21.4 mm Hg and 209.0 ± 42.9 mm Hg, respectively (P<.0001). Eight corneal incisions and 8 scleral incisions did not leak at the maximum pressure of 246 mm Hg. With both incision types, the difference in leakage with a liquid bandage in place and with no liquid bandage was statistically significant (P = .002).
  
  
  CONCLUSIONS
  With application of a hydrogel liquid ocular bandage, incisions withstood significantly higher IOP before leakage occurred than when no liquid bandage was used.
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.
authors.forename: Surekha
authors.initials: S
authors.lastname: Maddula
authors.forename: Don K
authors.initials: DK
authors.lastname: Davis
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ness
authors.forename: Michael K
authors.initials: MK
authors.lastname: Burrow
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Olson
mesh_terms: D047070:Bandages, Hydrocolloid; D003315:Cornea / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008866:Microsurgery / Q000379:methods; D008954:Models, Biological; D011092:Polyethylene Glycols; D012590:Sclera / Q000601:surgery*; D013529:Surgical Wound Dehiscence / Q000503:physiopathology / Q000517:prevention & control*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D011092:Polyethylene Glycols