title: DAnCER: disease-annotated chromatin epigenetics resource.
abstract: Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically interacting proteins, and their disruption has been linked to a number of complex human diseases. CM remains largely unexplored, however, especially in higher eukaryotes such as human. Here we present the DAnCER resource, which integrates information on genes with CM function from five model organisms, including human. Currently integrated are gene functional annotations, Pfam domain architecture, protein interaction networks and associated human diseases. Additional supporting evidence includes orthology relationships across organisms, membership in protein complexes, and information on protein 3D structure. These data are available for 962 experimentally confirmed and manually curated CM genes and for over 5000 genes with predicted CM function on the basis of orthology and domain composition. DAnCER allows visual explorations of the integrated data and flexible query capabilities using a variety of data filters. In particular, disease information and functional annotations are mapped onto the protein interaction networks, enabling the user to formulate new hypotheses on the function and disease associations of a given gene based on those of its interaction partners. DAnCER is freely available at http://wodaklab.org/dancer/.
authors.affiliation: Hospital for Sick Children, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Andrei L
authors.initials: AL
authors.lastname: Turinsky
authors.forename: Brian
authors.initials: B
authors.lastname: Turner
authors.forename: Rosanne C
authors.initials: RC
authors.lastname: Borja
authors.forename: James A
authors.initials: JA
authors.lastname: Gleeson
authors.forename: Michael
authors.initials: M
authors.lastname: Heath
authors.forename: Shuye
authors.initials: S
authors.lastname: Pu
authors.forename: Thomas
authors.initials: T
authors.lastname: Switzer
authors.forename: Dong
authors.initials: D
authors.lastname: Dong
authors.forename: Yunchen
authors.initials: Y
authors.lastname: Gong
authors.forename: Tuan
authors.initials: T
authors.lastname: On
authors.forename: Xuejian
authors.initials: X
authors.lastname: Xiong
authors.forename: Andrew
authors.initials: A
authors.lastname: Emili
authors.forename: Jack
authors.initials: J
authors.lastname: Greenblatt
authors.forename: John
authors.initials: J
authors.lastname: Parkinson
authors.forename: Zhaolei
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shoshana J
authors.initials: SJ
authors.lastname: Wodak
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002843:Chromatin / Q000378:metabolism*; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D057890:Epigenomics; D006801:Humans; D051379:Mice; D058977:Molecular Sequence Annotation; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D002843:Chromatin