Inhibition of gap junctional intercellular communication by toxic metals.
As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of cellular signaling mediated by gap junctions. This paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminum, lead, nickel, vanadium, and indium on gap junctional intercellular communication. Whenever available, particular attention is paid to the mechanistic basis of this deleterious biological outcome, which may involve the gap junction activity level or may arise from modifications in the expression of the gap junction building stones, the connexins.
Vinken
Mathieu
M
Department of Toxicology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. mvinken@vub.ac.be
Ceelen
Liesbeth
L
Vanhaecke
Tamara
T
Rogiers
Vera
V
D002450:Cell Communication / Q000187:drug effects* / Q000502:physiology; D017630:Connexins / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D017629:Gap Junctions / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008670:Metals / Q000633:toxicity*
D017630:Connexins; D004785:Environmental Pollutants; D008670:Metals