Report: synthesis and evaluation of mannich bases of Benzimidazo [1,2-c] quinazolin- 6(5h)-thione for antimicrobial activity.
The intermediate Benzimidazo[1,2-c] quinazolin-6(5H)-thione (1) was obtained by cyclization of 2-(2'-aminophenyl) benzimidazole with carbon disulfide. Mannich base (2a-d) of compound (1) was obtained on treatment with Para formaldehyde and secondary aliphatic amines, similarly treatment of (1) with different ketones afforded respective mannich bases (3 e-h). All derivatives synthesized were characterized from IR and 1HNMR spectral data's. Moderate anti bacterial activity was exhibited from 2a-d and from 3f, 3h against S. aureus, E. coli, and E. fecalis but very negligent activity were seen from these compounds when screened against P aeruginosa.
Saraswathi
M
M
Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore, India. rm_rohini@rediffmail.com
Rohini
R M
RM
Ranaprathapsingh
Nayeem
Naira
N
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012997:Solvents; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D001562:Benzimidazoles; D007202:Indicators and Reagents; D008352:Mannich Bases; D011799:Quinazolines; D012997:Solvents; D013871:Thiones; C554581:benzimidazo(1,2-c)quinazolin-6(5h)-thione; D004121:Dimethyl Sulfoxide