Prolidase activity and its diagnostic performance in bipolar disorder.
OBJECTIVE
Proline has an important role in the brain. Prolidase, a proline splitting enzyme, which is also involved in oxidative stress is not investigated in bipolar disorder (BD).


METHODS
66 BD type I patients and 66 healthy controls were enrolled. Serum prolidase activity was measured in both groups via venous sampling. We have compared patients and controls as well as 3 subgroups of patients (24 euthymic, 22 manic, and 20 depressive patients).


RESULTS
Prolidase activity was significantly higher in patients (p<0.001, t=14.517). There wasn't any significant difference among euthymic, manic and depressives (p=0.305, f=1.211). Positive predictive value was 98.5% and negative predictive value was 92.4% above the cutoff point 502.9375U/L of prolidase activity.


CONCLUSIONS
Prolidase activity is impaired in BD, which may be associated with oxidative stress. Prolidase activity may be a trait marker for diagnosing bipolar disorder.
Selek
Salih
S
Psychiatry Department, Medical School, Harran University, S.Urfa, Turkey. drselek@yahoo.com
Altindag
Abdurrahman
A
Saracoglu
Gulben
G
Celik
Hakim
H
Aksoy
Nurten
N
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003866:Depressive Disorder / Q000097:blood / Q000201:enzymology; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D012372:ROC Curve
D015415:Biomarkers; D004150:Dipeptidases; C022449:proline dipeptidase