title: Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.
abstract: RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular functions in regulating transcription, RNA processing, translation and protein translocation. RNA polymerase III transcription activity is tightly regulated during the cell cycle and coupled to growth control mechanisms. Furthermore, there are reports of changes in RNA polymerase III transcription activity during cellular differentiation, including the discovery of a novel isoform of human RNA polymerase III that has been shown to be specifically expressed in undifferentiated human H1 embryonic stem cells. Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation.
authors.affiliation: Institut Européen de Chimie et Biologie (I.E.C.B.), Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM) U869, Pessac, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Dumay-Odelot
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Durrieu-Gaillard
authors.forename: Daniel
authors.initials: D
authors.lastname: Da Silva
authors.forename: Robert G
authors.initials: RG
authors.lastname: Roeder
authors.forename: Martin
authors.initials: M
authors.lastname: Teichmann
mesh_terms: D002454:Cell Differentiation; D048708:Cell Growth Processes; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D011401:Promoter Regions, Genetic; D020033:Protein Isoforms / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012320:RNA Polymerase III / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D020033:Protein Isoforms; D014157:Transcription Factors; D012313:RNA; D012320:RNA Polymerase III