title: MRI evaluation of white matter recovery after brain injury.
abstract: We discuss the use of MRI in detecting and staging white matter reorganization after brain injury with and without neurorestorative treatment. Based on variations of diffusion tensor MRI (DTI) methodology, we demonstrate that MRI can detect white matter remodeling after brain injury. In addition, we demonstrate that Q-space DTI can detect early stage axonal remodeling, which involves randomly oriented crossing axons. With the information obtained from conventional and Q-space DTI, it is possible to stage white matter remodeling after brain injury.
authors.affiliation: Department of Neurology, Henry Ford Health System, Detroit, Mich 48202, USA. qjiang1@hfhs.org
authors.forename: Quan
authors.initials: Q
authors.lastname: Jiang
authors.forename: Zheng Gang
authors.initials: ZG
authors.lastname: Zhang
authors.forename: Michael
authors.initials: M
authors.lastname: Chopp
mesh_terms: D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology* / Q000534:rehabilitation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009413:Nerve Fibers, Myelinated / Q000473:pathology*