title: Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune-Albright syndrome.
abstract: We report a rare case of polyostotic fibrous dysplasia on endocrine hyperfunction with elevated human growth hormone and normal serum level of prolactin. There were some differential points of gender, gigantism, endocrine function, and GNAS gene from McCune-Albright syndrome. Malignant transformation was suspected in the pelvic tumor from imaging because rapid growth of the tumor by imaging was observed; however, no malignant change occurred in this case.
authors.affiliation: Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0204, Japan. kenshi@m.ehime-u.ac.jp
authors.forename: Kenshi
authors.initials: K
authors.lastname: Sakayama
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Teruki
authors.initials: T
authors.lastname: Kidani
authors.forename: Taketsugu
authors.initials: T
authors.lastname: Fujibuchi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kito
authors.forename: Nozomu
authors.initials: N
authors.lastname: Tanji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakamura
mesh_terms: D000172:Acromegaly / Q000175:diagnosis; D000328:Adult; D001849:Bone Diseases, Endocrine / Q000150:complications / Q000175:diagnosis; D001859:Bone Neoplasms / Q000175:diagnosis; D002864:Chromogranins; D003937:Diagnosis, Differential; D005359:Fibrous Dysplasia, Polyostotic / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000378:metabolism; D005877:Gigantism / Q000175:diagnosis; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D010386:Pelvic Neoplasms / Q000150:complications* / Q000601:surgery*; D010900:Pituitary Diseases / Q000150:complications; D011388:Prolactin / Q000097:blood
chemical_list: D002864:Chromogranins; D019382:Human Growth Hormone; D011388:Prolactin; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs