title: Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.
abstract: The ethanolic root extract of C. zambesicus (27-81mg/kg) was evaluated for antiiflammatory, analgesic and antipyretic properties in mice. The extract (27-81mg/kg) demonstrated a weak antiinflammatory activity. However, a significant (P<0.01-0.001) analgesic and antipyretic activities were observed in all the experimental models tested. The extract may be exerting its effects through central mechanisms. These findings confirms its ethnomedical use in the treatment of malarial-associated symptoms.
authors.affiliation: Department of Pharmacology and Toxicology, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
authors.forename: Jude E
authors.initials: JE
authors.lastname: Okokon
authors.forename: Paul A
authors.initials: PA
authors.lastname: Nwafor
mesh_terms: D019342:Acetic Acid; D000661:Amphetamine; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D002351:Carrageenan; D029802:Croton / Q000737:chemistry*; D004140:Dinitrophenols; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D005557:Formaldehyde; D006358:Hot Temperature; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots; D051381:Rats; D012997:Solvents; D014992:Xylenes
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D004140:Dinitrophenols; D010936:Plant Extracts; D012997:Solvents; D014992:Xylenes; D005557:Formaldehyde; D000431:Ethanol; D002351:Carrageenan; D000661:Amphetamine; D019342:Acetic Acid