Resveratrol: a multifunctional cytoprotective molecule.
Several recent studies have shown the protective effects of resveratrol in various experimental conditions and pathological animal models. Clinical studies also indicate the beneficial effects of resveratrol in different human diseases. Resveratrol produces a cascade against of events from the initial death-provoking signal, DNA fragmentation, and cell death. Researchers recognized the beneficial effect of resveratrol, as an important component, of the overall injury that occurs in various disorders such as oxidative stress, myocardial injury, anticancer activity, antidiabetic activity, and antihypercholesterolemic effects. Many mechanisms have been proposed for the initiation of protective effects of resveratrol in various pathological events, and considerable evidence exists to indicate that many mediators are involved in the resveratrol-induced protection. The present review focuses on the history, and the beneficial effects and mechanisms of resveratrol in oxidative stress, myocardial injury, anticancer-, antidiabetic- and antihypercholesterolemic activities, and discusses those therapeutic tools, which warrant becoming clinically important.
Juhasz
Bela
B
Department of Pharmacology, Faculty of Pharmacy, Health and Science Center, University of Debrecen, 4032-Debrecen, Hungary. frog@king.pharmacol.dote.hu
Varga
Balazs
B
Gesztelyi
Rudolf
R
Kemeny-Beke
Adam
A
Zsuga
Judit
J
Tosaki
Arpad
A
D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D019610:Cytoprotection; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D019157:Ischemic Preconditioning, Myocardial; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D008517:Phytotherapy; D028321:Plant Preparations; D015427:Reperfusion Injury / Q000517:prevention & control; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D028321:Plant Preparations; D013267:Stilbenes; D000077185:Resveratrol