Epigenetic mechanisms and the relationship to childhood asthma.
Epigenetic mechanisms mediate genomic adaption to the environment and epigenetic alterations can contribute to the development of disease phenotypes, as can genetic variants. A variety of molecular mechanisms are involved in epigenetic regulation, including post-transcriptional histone modifications, histone variants, ATP-dependent chromatin remodelling complexes, polycomb/trithorax protein complexes, small and other noncoding RNAs (small interfering RNA and micro RNAs) and DNA methylation. Epigenetic mechanisms have been identified in cancer but very little is known about these effects in complex diseases such as asthma. Epigenetic mechanisms have been found to play a primordial role in T-cell differentiation and novel aspects of asthma and allergy development are now investigated by systematic epigenetic studies. Here we give an introduction to epigenetics, review the existing literature in relation to asthma and asthma-related mechanisms and hypothesise on feasible approaches for the study of epigenetics in asthma in the future.
Kabesch
M
M
Centre for Paediatrics, Clinic for Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625, Hannover, Germany. kabesch.michael@mh-hannover.de
Michel
S
S
Tost
J
J
D001249:Asthma / Q000175:diagnosis / Q000235:genetics*; D002454:Cell Differentiation; D002648:Child; D002843:Chromatin / Q000378:metabolism; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics; D007249:Inflammation; D008957:Models, Genetic; D022661:RNA, Untranslated / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology; D018417:Th1 Cells / Q000166:cytology; D018418:Th2 Cells / Q000166:cytology
D002843:Chromatin; D022661:RNA, Untranslated