title: Novel vesicles self-assembled from amphiphilic star-armed PEG/polypeptide hybrid copolymers for drug delivery.
abstract: A novel amphiphilic four-armed [poly(ε-benzyloxycarbonyl-L-lysine)]₂-block-poly(ethylene glycol)-block-[poly(ε-benzyloxycarbonyl-L-lysine)]₂ hybrid copolymer has been prepared. The cytotoxicity study shows that the copolymer has good biocompatibility with no obvious inhibition effect on cell growth. The amphiphilic copolymers could self-assemble to form vesicles in aqueous solution. DOX · HCl, as a hydrophilic drug, can be loaded into the vesicles, and then successfully internalized by human breast cancer MCF-7 cells. Importantly, the DOX-loaded vesicles show a greatly improved drug release behavior with a zero-order release at the initial stage, suggesting a great potential as the carrier of hydrophilic drugs for controlled drug delivery.
authors.affiliation: The Institute for Advanced Materials and Nano Biomedicine (iNANO), Tongji University, Shanghai 200092, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Dong
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Wen
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.forename: Cao
authors.initials: C
authors.lastname: Li
authors.forename: Yong-Yong
authors.initials: YY
authors.lastname: Li
authors.forename: Helen N
authors.initials: HN
authors.lastname: Jones
authors.forename: Dong-Lu
authors.initials: DL
authors.lastname: Shi
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008856:Microscopy, Fluorescence; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: C558159:(poly(epsilon-benzyloxycarbonyllysine))2-block-poly(ethylene glycol)-block-(poly(epsilon-benzyloxycarbonyllysine))2; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008823:Micelles; D011107:Polylysine; C038295:poly(N(epsilon)-benzyloxycarbonyl-L-lysine); D011092:Polyethylene Glycols; D004317:Doxorubicin