VEP contrast sensitivity responses reveal reduced functional segregation of mid and high filters of visual channels in autism.
Despite the vast amount of behavioral data showing a pronounced tendency in individuals with autism spectrum disorder (ASD) to process fine visual details, much less is known about the neurophysiological characteristics of spatial vision in ASD. Here, we address this issue by assessing the contrast sensitivity response properties of the early visual-evoked potentials (VEPs) to sine-wave gratings of low, medium and high spatial frequencies in adults with ASD and in an age- and IQ-matched control group. Our results show that while VEP contrast responses to low and high spatial frequency gratings did not differ between ASD and controls, early VEPs to mid spatial frequency gratings exhibited similar response characteristics as those to high spatial frequency gratings in ASD. Our findings show evidence for an altered functional segregation of early visual channels, especially those responsible for processing mid- and high-frequency spatial scales.
Jemel
Boutheina
B
Research Laboratory in Neuroscience and Cognitive Electrophysiology, Hôpital Rivière des Prairies, Université de Montréal, Montreal, Canada. boutheina.jemel@umontreal.ca
Mimeault
Daniel
D
Saint-Amour
Dave
D
Hosein
Anthony
A
Mottron
Laurent
L
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000503:physiopathology*; D015350:Contrast Sensitivity / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D055815:Young Adult