title: Late-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus?
abstract: Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder, typically presenting in the second and third decade. We report the case of an elderly gentleman with significant vascular risk factors, presenting with slowly progressive, bilateral, visual loss with high signal lesions in the pericallosal and periventricular deep white matter on MRI brain studies. Possible diagnoses included late-onset MS, ischaemic optic neuropathies, a mitochondrial disorder or an overlap syndrome such as Harding's disease.
authors.affiliation: Department of Neurology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
authors.forename: N
authors.initials: N
authors.lastname: Cawley
authors.forename: A
authors.initials: A
authors.lastname: Molloy
authors.forename: L
authors.initials: L
authors.lastname: Cassidy
authors.forename: N
authors.initials: N
authors.lastname: Tubridy
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis; D009154:Mutation; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis* / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology / Q000235:genetics