title: Interferon-γ and IL-5 production correlate directly in HIV patients co-infected with mycobacterium tuberculosis with or without immune restoration disease.
abstract: IL-5 and interferon-γ responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration disease (IRD) associated with M. tuberculosis after starting antiretroviral therapy (ART). Interferon-γ levels were constant on ART, whilst IL-5 levels generally rose over time. We suggest that increased IL-5 production reflects a recovery of CD4(+) T cell function and that a Th1/Th2 imbalance is not associated with increased susceptibility to M. tuberculosis disease or IRD associated with M. tuberculosis upon starting ART.
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia. 10114374@student.uwa.edu.au
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Oliver
authors.forename: Julian H
authors.initials: JH
authors.lastname: Elliott
authors.forename: Vonthanak
authors.initials: V
authors.lastname: Saphonn
authors.forename: Mean Chhi
authors.initials: MC
authors.lastname: Vun
authors.forename: Martyn A
authors.initials: MA
authors.lastname: French
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001769:Blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D004198:Disease Susceptibility; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D015848:Interleukin-5 / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D019380:Anti-HIV Agents; C508599:IL5 protein, human; D015848:Interleukin-5; D007371:Interferon-gamma