A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes.
A novel nucleoside analog with a disulfide bridge structure at the sugar moiety, which shows redox-responsive reversibility of the sugar conformation due to formation and scission of the disulfide bond, was designed and synthesized.
Baba
Takeshi
T
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kodama
Tetsuya
T
Mori
Kazuto
K
Imanishi
Takeshi
T
Obika
Satoshi
S
D002241:Carbohydrates / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D010084:Oxidation-Reduction
D002241:Carbohydrates; D009705:Nucleosides