title: An introduction to adaptive designs and adaptation in CNS trials.
abstract: Adaptive designs learn from accumulating trial data in real time and apply this knowledge to optimize subsequent study execution. A set of design rules define a priori which modifications may be incorporated into the trial design. Judicious use of adaptive designs may increase the information value per resource unit invested by avoiding allocation of patients to non-efficacious/unsafe therapies and allowing stopping decisions to be made at the earliest possible time point. Ultimately this may accelerate the development of promising therapies.
authors.affiliation: Vladimir.Dragalin@quintiles.com
authors.forename: Vladimir
authors.initials: V
authors.lastname: Dragalin
mesh_terms: D002491:Central Nervous System Agents / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D015195:Drug Design; D006801:Humans; D012107:Research Design; D013997:Time Factors
chemical_list: D002491:Central Nervous System Agents