title: A 4-decade-long (and still ongoing) hunt for palytoxins chemical architecture.
abstract: Since its isolation dated back to as far as 1971, palytoxin has all along drawn scientists' attention from across the world because of its high toxicity and fascinating chemical architecture. Commitment of the international scientific community to the study of this extremely potent non-proteic toxin has led to discover quite a number of palytoxin analogues. Once confined only to tropical and subtropical areas, palytoxins have recently spread also to more temperate regions, such as the Mediterranean Sea where they have caused severe human intoxications. Studies on the Mediterranean toxic outbreaks brought to light the existence of further palytoxin-like compounds, ovatoxins, never reported elsewhere in the world.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", via D. Montesano 49, 80131 Napoli, Italy. ciminiel@unina.it
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ciminiello
authors.forename: Carmela
authors.initials: C
authors.lastname: Dell'Aversano
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Martino
authors.initials: M
authors.lastname: Forino
authors.forename: Laura
authors.initials: L
authors.lastname: Grauso
authors.forename: Luciana
authors.initials: L
authors.lastname: Tartaglione
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000379:methods; D003064:Cnidarian Venoms; D004141:Dinoflagellida / Q000737:chemistry*; D008387:Marine Toxins / Q000737:chemistry*; D015394:Molecular Structure; D053719:Tandem Mass Spectrometry; D000095702:Polyether Toxins
chemical_list: D000178:Acrylamides; D003064:Cnidarian Venoms; D008387:Marine Toxins; C010272:palytoxin; D000095702:Polyether Toxins