title: Nearly identical near-haploid karyotype in a peritoneal mesothelioma and a retroperitoneal malignant peripheral nerve sheath tumor.
abstract: The presence of a near-haploid karyotype is a rare finding in human malignancies, most frequently occurring in acute leukemia. In solid tumors, a near-haploid karyotype has been reported in fewer than 40 cases. We report two nearly identical near-haploid karyotypes from two distinctly different tumor types. The first case is a biphasic malignant mesothelioma from a 53-year-old white woman forming a large retroperitoneal mass. Cytogenetic evaluation revealed a primary hyperdiploid cell population as well as near-haploid and hypertetraploid populations with an overall karyotype of 27,XX,i(5)(p10),+7,add(15)(p11.2),+dic(1;20)(p13;p13)[2]/54,idemx2[90]/101-108,idemx4[19]. The second case is a large pelvic mass from a 48-year-old man. Histologic examination identified a malignant peripheral nerve sheath tumor displaying a karyotype of 26,X,+i(5)(p10),+7,der(15)t(1;15)(q12;p12),+20[5]/52,idemx2[20]. Herein we discuss the potential relationship between these two disparate neoplasms with nearly identical near-haploid karyotypes and present a literature review.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Sukov
authors.forename: Rhett P
authors.initials: RP
authors.lastname: Ketterling
authors.forename: Sainan
authors.initials: S
authors.lastname: Wei
authors.forename: Kristin
authors.initials: K
authors.lastname: Monaghan
authors.forename: Paul
authors.initials: P
authors.lastname: Blunden
authors.forename: Paul
authors.initials: P
authors.lastname: Mazzara
authors.forename: Ravi
authors.initials: R
authors.lastname: Raghavan
authors.forename: Andre M
authors.initials: AM
authors.lastname: Oliviera
authors.forename: Anne E
authors.initials: AE
authors.lastname: Wiktor
authors.forename: Gary L
authors.initials: GL
authors.lastname: Keeney
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Van Dyke
mesh_terms: D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D008297:Male; D008654:Mesothelioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000235:genetics / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000235:genetics* / Q000473:pathology; D012187:Retroperitoneal Space / Q000473:pathology*