title: Designing microcapsule arrays that propagate chemical signals.
abstract: Using analysis and simulation, we show how ordered arrays of microcapsules in solution can be harnessed to propagate chemical signals in directed and controllable ways, allowing the signals to be transmitted over macroscopic distances. The system encompasses two types of capsules that are localized on an adhesive surface. The "signaling" capsules release inducer molecules, which trigger "targets" to release nanoparticles. The released nanoparticles can bind to the underlying surface and thus, create adhesion gradients, which then propel the signaling capsules to shuttle between neighboring targets. This arrangement acts like a relay, so that triggering target capsules at a particular location in the array also triggers target capsules in adjacent locations. For an array containing two target columns, our simulations and analysis show that steady input signal leads to a sustained periodic output. For an array containing multiple target columns, we show that by introducing a prescribed ratio of nanoparticle release rates between successive target columns, a chemical signal can be propagated along the array without dissipation. We also demonstrate that similar signal transmission cannot be performed via diffusion alone.
authors.affiliation: Chemical Engineering Department, University of Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Amitabh
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Anna C
authors.initials: AC
authors.lastname: Balazs
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D002214:Capsules; D003198:Computer Simulation; D004058:Diffusion; D008956:Models, Chemical; D009038:Motion; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D001704:Biopolymers; D002214:Capsules