title: Solving the problem of concomitant gradients in ultra-low-field MRI.
abstract: In ultra-low-field magnetic resonance imaging (ULF MRI), spin precession is detected typically in magnetic fields of the order of 10-100 μT. As in conventional high-field MRI, the spatial origin of the signals can be encoded by superposing gradient fields on a homogeneous main field. However, because the main field is weak, gradient field amplitudes become comparable to it. In this case, the concomitant gradients forced by Maxwell's equations cause the assumption of linearly varying field gradients to fail. Thus, image reconstruction with Fourier transformation would produce severe image artifacts. We propose a direct linear inversion (DLI) method to reconstruct images without limiting assumptions about the gradient fields. We compare the quality of the images obtained using the proposed reconstruction method and the Fourier reconstruction. With simulations, we show how the reconstruction errors of the methods depend on the strengths of the concomitant gradients. The proposed approach produces nearly distortion-free images even when the main field reaches zero.
authors.affiliation: Aalto University, Department of Biomedical Engineering and Computational Science, P.O. Box 12200, FI-00076 Aalto, Finland. jaakko.nieminen@tkk.fi
authors.forename: Jaakko O
authors.initials: JO
authors.lastname: Nieminen
authors.forename: Risto J
authors.initials: RJ
authors.lastname: Ilmoniemi
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003198:Computer Simulation; D004574:Electromagnetic Fields; D005583:Fourier Analysis; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D016011:Normal Distribution; D019047:Phantoms, Imaging; D014867:Water
chemical_list: D014867:Water