A 4-decade-long (and still ongoing) hunt for palytoxins chemical architecture.
Since its isolation dated back to as far as 1971, palytoxin has all along drawn scientists' attention from across the world because of its high toxicity and fascinating chemical architecture. Commitment of the international scientific community to the study of this extremely potent non-proteic toxin has led to discover quite a number of palytoxin analogues. Once confined only to tropical and subtropical areas, palytoxins have recently spread also to more temperate regions, such as the Mediterranean Sea where they have caused severe human intoxications. Studies on the Mediterranean toxic outbreaks brought to light the existence of further palytoxin-like compounds, ovatoxins, never reported elsewhere in the world.
Ciminiello
Patrizia
P
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", via D. Montesano 49, 80131 Napoli, Italy. ciminiel@unina.it
Dell'Aversano
Carmela
C
Fattorusso
Ernesto
E
Forino
Martino
M
Grauso
Laura
L
Tartaglione
Luciana
L
D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000379:methods; D003064:Cnidarian Venoms; D004141:Dinoflagellida / Q000737:chemistry*; D008387:Marine Toxins / Q000737:chemistry*; D015394:Molecular Structure; D053719:Tandem Mass Spectrometry; D000095702:Polyether Toxins
D000178:Acrylamides; D003064:Cnidarian Venoms; D008387:Marine Toxins; C010272:palytoxin; D000095702:Polyether Toxins