Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth.
Estradiol enhanced stromal cell-derived factor 1 (SDF-1/CXCL12) production levels in human endometrial stromal cells (ESCs) in a time- and dose-dependent manner that could be completely abolished by ICI 182,780 (estrogen receptor antagonist) and medroxyprogesterone acetate. Although SDF-1 was undetectable in the Ishikawa human endometrial epithelial cell line, its receptor (CXCR4) messenger RNA levels in Ishikawa cells were much higher than those in ESCs, and furthermore SDF-1 induced the proliferation of Ishikawa cells; SDF-1 secreted from ESCs may play a role in endometrial epithelial cell growth in the paracrine system.
Tsutsumi
Akihiro
A
Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan.
Okada
Hidetaka
H
Nakamoto
Tsuyoshi
T
Okamoto
Rika
R
Yasuda
Katsuhiko
K
Kanzaki
Hideharu
H
D000328:Adult; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D054377:Chemokine CXCL12 / Q000378:metabolism*; D004717:Endometrium / Q000166:cytology*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D000077267:Fulvestrant; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D019899:Paracrine Communication / Q000187:drug effects / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D004965:Estrogen Antagonists; D004967:Estrogens; D000077267:Fulvestrant; D004958:Estradiol