Engineered hydrogen-bonded polymer multilayers: from assembly to biomedical applications.
Over the last two decades the layer-by-layer (LbL) assembly technique has become a highly versatile platform for the synthesis of nanoengineered thin films and particles. The widespread need for highly functional and responsive materials for applications in biomedicine-such as drug and gene delivery-has recently led to considerable efforts in the assembly of LbL materials, particularly films that can be subsequently stabilised and functionalised through a range of chemistries. In this tutorial review, recent developments in hydrogen-bonded LbL-assembled materials will be discussed, focusing on the design of materials with enhanced stimuli-responsive characteristics. Emphasis will be given to materials engineered for biomedical applications, specifically films/capsules that afford controlled loading and release of therapeutic cargo for application in vitro and in vivo.
Such
Georgina K
GK
Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Johnston
Angus P R
AP
Caruso
Frank
F
D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002214:Capsules / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D006860:Hydrogen Bonding; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry
D000178:Acrylamides; D000180:Acrylic Resins; D000970:Antineoplastic Agents; D002214:Capsules; D004337:Drug Carriers; D011108:Polymers; D011109:Polymethacrylic Acids; C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols; D011205:Povidone