Artesunate misuse and Plasmodium falciparum malaria in traveler returning from Africa.
Plasmodium falciparum malaria developed in an African-born traveler who returned to Canada after visiting Nigeria. While there, she took artesunate prophylactically. Isolates had an elevated 50% inhibitory concentration to artemisinin, artesunate, and artemether, compared with that of other African isolates. Inappropriate use of artemisinin derivatives can reduce P. falciparum susceptibility.
Shahinas
Dea
D
University of Toronto, Toronto, Ontario, Canada.
Lau
Rachel
R
Khairnar
Krishna
K
Hancock
David
D
Pillai
Dylan R
DR
D000328:Adult; D000349:Africa; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000077332:Artesunate; D002170:Canada; D018890:Chemoprevention; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000469:parasitology / Q000517:prevention & control*; D009549:Nigeria; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D012651:Self Medication / Q000009:adverse effects*; D014195:Travel
D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate