Neurotoxic in vivo models of Parkinson's disease recent advances.
Animal models have been invaluable to Parkinson's disease (PD) research. Of these, neurotoxin models have historically been the most widely utilized. The goal of this chapter is to give a brief historical description of classic PD models and then to identify the most recent important advances in modeling human PD in animals. Indeed, significant advances in modeling additional features of PD and expansion to new species have occurred in both older and newer models. The roles these new advances in modeling may have in future PD research are examined in this chapter.
Cannon
Jason R
JR
Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Greenamyre
J Timothy
JT
D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D020267:MPTP Poisoning / Q000473:pathology / Q000523:psychology; D020258:Neurotoxicity Syndromes / Q000473:pathology* / Q000523:psychology; D009498:Neurotoxins / Q000633:toxicity; D016627:Oxidopamine; D010269:Paraquat / Q000633:toxicity; D010300:Parkinson Disease / Q000473:pathology* / Q000523:psychology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000523:psychology; D012402:Rotenone / Q000633:toxicity; D013565:Sympatholytics; D014475:Uncoupling Agents / Q000633:toxicity
D009498:Neurotoxins; D013565:Sympatholytics; D014475:Uncoupling Agents; D012402:Rotenone; D016627:Oxidopamine; D010269:Paraquat; D004298:Dopamine