Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.
Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.
Guarracino
Danielle A
DA
Department of Chemistry, New York University, New York, NY 10003, USA.
Bullock
Brooke N
BN
Arora
Paramjit S
PS
D032701:Biomimetics; D001704:Biopolymers / Q000737:chemistry*; D015195:Drug Design; D008024:Ligands; D017433:Protein Structure, Secondary; D011506:Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic
D001704:Biopolymers; D008024:Ligands; D011506:Proteins