The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field.
Leukotrienes (LTs) are potent biological proinflammatory mediators. LTC4, LTD4, and LTE4 are more frequently involved in chronic inflammatory responses and exert their actions binding to a cysteinyl-LT 1 (CysLT1) receptor and a cysteinyl-LT 2 (CysLT2) receptor. LTs receptor antagonists available for clinical use demonstrate high-affinity binding to the CysLT1 receptor. In this paper the employment of anti-LTs in allergic cutaneous diseases is analyzed showing that several studies have recently reported a beneficial effects of these agents (montelukast and zafirlukast as well as zileuton) for the treatment of some allergic cutaneous related diseases-like chronic urticaria and atopic eczema although their proper application remains to be established.
Nettis
Eustachio
E
Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Piazza Giulio Cesare, 70124 Bari, Italy. e.nettis@allergy.uniba.it
D'Erasmo
Maddalena
M
Di Leo
Elisabetta
E
Calogiuri
Gianfranco
G
Montinaro
Vincenzo
V
Ferrannini
Antonio
A
Vacca
Angelo
A
D000085:Acetates / Q000627:therapeutic use; D000818:Animals; D003521:Cyclopropanes; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D048448:Phenylcarbamates; D011804:Quinolines / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy*; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000627:therapeutic use
D000085:Acetates; D003521:Cyclopropanes; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D011804:Quinolines; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds; C093875:montelukast; C062735:zafirlukast