Copper stress targets the rcs system to induce multiaggregative behavior in a copper-sensitive Salmonella strain.
Salmonella ΔcuiD strains form mucoid colonies on copper-containing solid media. We show here that this multiaggregative behavior is caused by the Rcs-dependent induction of colanic acid extracellular polysaccharide. Deletion of cps operon genes in a ΔcuiD strain increased the sensitivity to copper, indicating a role for colanic acid in copper resistance.
Pontel
Lucas B
LB
Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas (IBR-CONICET), Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Pezza
Alejandro
A
Soncini
Fernando C
FC
D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics; D053898:Biosynthetic Pathways / Q000235:genetics*; D003300:Copper / Q000633:toxicity*; D003470:Culture Media / Q000737:chemistry; D009876:Operon; D011134:Polysaccharides / Q000096:biosynthesis; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D012475:Salmonella / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D017384:Sequence Deletion
D001426:Bacterial Proteins; D003470:Culture Media; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D003300:Copper; C004275:colanic acid