title: Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy.
abstract: Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.
authors.affiliation: Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Dierksen
authors.forename: Maureen E
authors.initials: ME
authors.lastname: Skehan
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Khan
authors.forename: Jed
authors.initials: J
authors.lastname: Jeng
authors.forename: R N Kaveer
authors.initials: RN
authors.lastname: Nandigam
authors.forename: John A
authors.initials: JA
authors.lastname: Becker
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Krista L
authors.initials: KL
authors.lastname: Neal
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Betensky
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Frosch
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.forename: Anand
authors.initials: A
authors.lastname: Viswanathan
authors.forename: David H
authors.initials: DH
authors.lastname: Salat
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
mesh_terms: D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D016657:Cerebral Amyloid Angiopathy / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D013844:Thiazoles