title: Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?
abstract: Several studies suggest that the response to various stressors differs between the sexes. We aimed to study serum HSP70 and levels of oxidized-LDL (ox-LDL) as markers of oxidative stress in men and women with type 2 diabetes. We quantified serum HSP70 and levels of ox-LDL in three cohorts; patients with newly diagnosed diabetes, patients with long-standing diabetes and normal controls. The cohort of patients with newly diagnosed diabetes was followed up for 3 months under glucose-lowering therapy with metformin. Our findings showed that serum HSP70 level was increased in women with long-standing diabetes in comparison with men. HSP70 did not decrease after glucose lowering therapy in women with newly diagnosed diabetes, but it did decrease in men. There was no significant difference on ox-LDL between men and women in any of the studied cohorts. It decreased significantly in the cohort of patients with newly diagnosed diabetes after treatment, regardless of sex. There was no significant correlation between HSP70 and ox-LDL in any of the studied cohorts except among normal women. We suggest that diabetes induces an immune response and impairs cellular defense mechanisms against oxidative stress more commonly in women with type 2 diabetes than in men.
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. nakhjavanim@tums.ac.ir
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Nakhjavani
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Morteza
authors.forename: Alipasha
authors.initials: A
authors.lastname: Meysamie
authors.forename: Alireza
authors.initials: A
authors.lastname: Esteghamati
authors.forename: Omid
authors.initials: O
authors.lastname: Khalilzadeh
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Esfahanian
authors.forename: Leyla
authors.initials: L
authors.lastname: Khajeali
authors.forename: Firouzeh
authors.initials: F
authors.lastname: Feiz
mesh_terms: D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein