[Prevention of abnormal physiological and biochemical characteristics of red blood cells in carbon disulfide intoxication].
Experimental studies were conducted on 4 groups of 10 rats each: 1) intact animals (a control group); 2) inhalation of carbon disulfide at a concentration of 2.0 mg/m3 for 7 days; 3) prophylactic administration of the hepatoprotective agent Legalon (100 mg/kg of total polyphenols), followed by carbon disulfide inhalation for 7 days; 4) prophylactic administration of the biologically active additive Kalifen (100 mg/kg of total polyphenols for 7 days), followed by carbon disulfide inhalation. Animal survival after carbon disulfide inhalation was 80%; preadministration of Legalon or Kalifen increased survival up to 100%. Carbon disulfide inhalation was attended by abnormal size features of red blood cells, impairments in the antioxidant defense system and the ratio of phospholipid fractions to neutral lipids. Preadministration of Legalon or Kalifen before inhalation contributes to less abnormalities in the study physiological and biochemical parameters of erythrocyte membranes.
Kushnerova
N F
NF
Rakhmanin
Iu A
IuA
Kushnerova
T V
TV
Drugova
E S
ES
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002246:Carbon Disulfide / Q000506:poisoning*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D010743:Phospholipids / Q000378:metabolism; D011041:Poisoning / Q000097:blood / Q000517:prevention & control; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010743:Phospholipids; D059808:Polyphenols; D012838:Silymarin; D002246:Carbon Disulfide