title: The relationship between oxidative stress and coronary artery ectasia.
abstract: BACKGROUND
  Whereas coronary artery ectasia (CAE) is a rare abnormality of the coronary arteries, co-existent coronary artery disease (CAD) is commonly seen in CAE patients. Since a causative relationship has been shown to exist between oxidative stress and CAD, we sought to determine whether any relationship exists between oxidative stress and CAE.
  
  
  METHODS
  Fourty four patients with CAE (without CAD) and 86 controls (without any coronary disease) were recruited from among 1,520 patients undergoing coronary angiography. CAE subgroups were determined in accordance with the Markis classification system. Mean values for serum total oxidant status (TOS), total antioxidant status (TAS) and the oxidative stress index (OSI) were statistically compared between these two study groups and among CAE subgroups, with p = 0.05 set as the threshold for statistical significance.
  
  
  RESULTS
  TOS and OSI were significantly increased (p = 0.018 and 0.0002) and TAS decreased (p = 0.031) in the CAE versus control group. TOS and TAS were independently related to CAE (p = 0.037 and 0.039), with an r(2) of 0.127. Interestingly, however, among CAE subgroups, no differences were observed.
  
  
  CONCLUSIONS
  Oxidative stress might be implicated in the pathogenesis of CAE. Clinically-defined CAE subgroups did not differ in terms of oxidative stress status. However, the clinical implications of these findings are unclear and warrant further investigation.
authors.affiliation: Department of Cardiology, Harran University, Sanliurfa, Turkey. buyukhatipoglu@gmail.com
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sezen
authors.forename: Memduh
authors.initials: M
authors.lastname: Bas
authors.forename: Mustafa
authors.initials: M
authors.lastname: Polat
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.forename: Hakan
authors.initials: H
authors.lastname: Buyukhatipoglu
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kucukdurmaz
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kaya
authors.forename: Recep
authors.initials: R
authors.lastname: Demirbag
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D003330:Coronary Vessel Anomalies / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D016877:Oxidants