title: Severe Plasmodium vivax malaria, Brazilian Amazon.
abstract: We describe a case series of 17 patients hospitalized in Manaus (western Brazilian Amazon) with PCR-confirmed Plasmodium vivax infection who were treated with chloroquine and primaquine. The major complications were jaundice and severe anemia. No in vivo chloroquine resistance was detected. These data help characterize the clinical profile of severe P. vivax malaria in Latin America.
authors.affiliation: Fundacao de Medicina Tropical do Amazonas, Manaus, Brazil.
authors.forename: Márcia A
authors.initials: MA
authors.lastname: Alexandre
authors.forename: Cynthia O
authors.initials: CO
authors.lastname: Ferreira
authors.forename: André M
authors.initials: AM
authors.lastname: Siqueira
authors.forename: Belisa L
authors.initials: BL
authors.lastname: Magalhães
authors.forename: Maria Paula G
authors.initials: MP
authors.lastname: Mourão
authors.forename: Marcus V
authors.initials: MV
authors.lastname: Lacerda
authors.forename: Maria das Gracas C
authors.initials: Md
authors.lastname: Alecrim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000962:Antimalarials / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016780:Malaria, Vivax / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D011319:Primaquine / Q000627:therapeutic use; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine