title: Genetic correlation of blood pressure responses to dietary sodium and potassium intervention and cold pressor test in Chinese population.
abstract: We examined the genetic association between blood pressure (BP) responses to dietary sodium and potassium intervention and to cold pressor test (CPT) in a large family-based dietary feeding study. The dietary intervention and CPT were conducted among 1906 participants in rural China. The dietary intervention included three 7-day periods of low-sodium feeding (51.3 mmol per day), high-sodium feeding (307.8 mmol per day) and high-sodium feeding plus potassium supplementation (60 mmol per day). BP responses to high-sodium intervention had strong genetic correlations (ρ(G)) with both BP responses to low sodium (ρ(G)=-0.43 to -0.54, P-values=0.0005 to 0.03) and to potassium supplementation (ρ(G)=-0.41 to -0.49, P-values=0.001 to 0.005) interventions. Most environmental correlations between BP responses to various dietary interventions were significant. The ρ(G) between BP responses to CPT and to high-sodium intervention and potassium supplementation were statistically significant. For example, the ρ(G) between maximum BP responses to CPT and BP responses to high-sodium intervention was 0.37 (P=0.006) for systolic BP (SBP) and 0.41 (P=0.002) for diastolic BP (DBP). The ρ(G) between maximum BP responses to CPT and BP responses to potassium intervention was -0.42 (P=0.001) for SBP and -0.46 (P=0.001) for SBP. Our study suggests that there are common genetic determinants that influence BP responses to dietary sodium and potassium interventions and to CPT.
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. hmei@tulane.edu
authors.forename: H
authors.initials: H
authors.lastname: Mei
authors.forename: T K
authors.initials: TK
authors.lastname: Rice
authors.forename: D
authors.initials: D
authors.lastname: Gu
authors.forename: J E
authors.initials: JE
authors.lastname: Hixson
authors.forename: C E
authors.initials: CE
authors.lastname: Jaquish
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.forename: J-C
authors.initials: JC
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Cao
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: T N
authors.initials: TN
authors.lastname: Kelly
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.forename: J
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D002681:China; D003080:Cold Temperature; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017419:Potassium, Dietary / Q000008:administration & dosage*; D012982:Sodium, Dietary / Q000008:administration & dosage*
chemical_list: D017419:Potassium, Dietary; D012982:Sodium, Dietary