Stereoselective Negishi-like couplings between alkenyl and alkyl halides in water at room temperature.
Mix in water and then stir. That is all that is required in this new approach to stereoselective sp(3)-sp(2) cross-couplings between an alkyl and alkenyl halide. Prior formation of organozinc reagents is not required.
Krasovskiy
Arkady
A
Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States.
Duplais
Christophe
C
Lipshutz
Bruce H
BH
D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001966:Bromine / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature; D014867:Water / Q000737:chemistry
D000475:Alkenes; D000480:Alkynes; D014867:Water; D007455:Iodine; D001966:Bromine