[Oxidative stress induced by peroxynitrite].
Peroxynitrite which is formed in vivo under oxidative stress in a diffusion-controlled reaction between *NO and O2*- is a strong oxidizingand nitrating agent. It has been suggested that peroxynitrite is involved in the development of a variety of pathological conditions including diabetes, cardiovascular and neurodegenerative disorders. Several physiological routes for peroxynitrite decomposition have been found up to date. Among natural catalytical scavengers of peroxynitrite are peroxiredoxins, catalase, some peroxidases, methemoglobin and myoglobin. Reactions with synthetic perxynitite scavengers have been also studied. Successful results have been obtained for Mn(II), Mn(III) and Fe(III)-porphyrin.
Gebicka
Lidia
L
Instytut Techniki Radiacyjnej, Wydzial Chemiczny, Politechnika Łódzka, Łódź. lgebicka@mitr.p.lodz.pl
Didik
Joanna
J
D000818:Animals; D002374:Catalase / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008706:Methemoglobin / Q000737:chemistry / Q000378:metabolism; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D009566:Nitrates / Q000737:chemistry / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D010544:Peroxidases / Q000737:chemistry / Q000378:metabolism; D054464:Peroxiredoxins / Q000737:chemistry; D030421:Peroxynitrous Acid / Q000737:chemistry* / Q000378:metabolism*; D010944:Plants / Q000378:metabolism
D005609:Free Radicals; D009211:Myoglobin; D009566:Nitrates; D030421:Peroxynitrous Acid; D008706:Methemoglobin; D010544:Peroxidases; D054464:Peroxiredoxins; D002374:Catalase