Complications of ketorolac use in children undergoing operative fracture care.
BACKGROUND
Ketorolac is commonly used for pain relief perioperatively, but its safety is questioned in children undergoing orthopaedic surgery. The aims of this study are to evaluate the rates of osseous and soft tissue complications after operative pediatric fracture care in children treated with ketorolac, and to compare the rates to those in children treated without ketorolac.


METHODS
A retrospective review was conducted for 221 consecutive children who underwent operative fracture care by a single surgeon and were followed until fracture healing. Of the 221 children, 169 had received ketorolac perioperatively and 52 had not received. The children were evaluated for potential complications associated with the perioperative parenteral administration of ketorolac, specifically including nonunion, delayed union, need for transfusion, wound complications and infection.


RESULTS
There was no difference in overall complication rates between the 2 groups (P=0.928). There were 3 cases in which blood transfusion was needed, 2/169 (1.2%) in the ketorolac group and 1/52 (1.9%) in the nonketorolac group. The wound infection was comparable in the 2 groups, occurring in 1/52 (1.9%) patients in the nonketorolac group and in 4/169 (2.3%) patients in the ketorolac group. There were no cases of delayed union or nonunion in either group.


CONCLUSIONS
The results of this study indicate that perioperative ketorolac use does not increase the risk of complications after operative fracture care in children (P=0.928). Specifically, there was no increased risk with regard to infection or wound complications, and there were no cases of delayed union or nonunion.


METHODS
Level III.
Kay
Robert M
RM
Childrens Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. rkay@chla.usc.edu
Directo
Michael P
MP
Leathers
Michael
M
Myung
Karen
K
Skaggs
David L
DL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000601:surgery*; D017759:Fractures, Malunited; D006801:Humans; D007223:Infant; D020910:Ketorolac / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000188:drug therapy*; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk; D014946:Wound Infection / Q000453:epidemiology / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020910:Ketorolac