Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma.
OBJECTIVE
Positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy-D-glucose ((18) F-FDG) is considered to be the most beneficial imaging method for staging patients with non-Hodgkin's lymphoma (NHL). The intensity of (18) F-FDG accumulation may be determined by calculating the so-called standardised uptake value (SUV). The study aimed at assessing the benefit of SUV(max) determination in staging (18) F-FDG PET/CT in untreated patients with NHL.


METHODS
One hundred and forty-nine initial staging (18) F-FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUV(max) was determined.


RESULTS
The highest mean and median values of SUV(max) were observed in patients with diffuse large B-cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUV(max) < 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUV(max) values. On the other hand, a correlation of the Ki-67 proliferative index of tumour cells and SUV(max) was revealed (r = 0.409, P < 0.001). The geometric mean of SUV(max) in patients with Ki-67 ≤ 60 and those with Ki-67 > 60 was 8.8 and 14.3, respectively (P < 0.001).


CONCLUSIONS
The results confirm that SUV(max) is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUV(max) with the Ki-67 values suggests that SUV(max) might have a prognostic values in NHL.
Papajík
Tomáš
T
Department of Hemato-Oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic. tomas.papajik@fnol.cz
Mysliveček
Miroslav
M
Sedová
Zuzana
Z
Buriánková
Eva
E
Procházka
Vít
V
Koranda
Pavel
P
Raida
Luděk
L
Kubová
Zuzana
Z
Palová
Miroslava
M
Kučerová
Ladislava
L
Flodr
Patrik
P
Jarkovský
Jiří
J
Dušek
Ladislav
L
Indrák
Karel
K
D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods* / Q000592:standards; D049268:Positron-Emission Tomography / Q000379:methods* / Q000592:standards; D011379:Prognosis; D012680:Sensitivity and Specificity
D019394:Ki-67 Antigen; D019788:Fluorodeoxyglucose F18; D007770:L-Lactate Dehydrogenase