Cellular binding of nanoparticles in the presence of serum proteins.
Cellular binding of cationic nanoparticles in the presence of serum proteins was probed with two-colour fluorescence microscopy. Cationic nanoparticles associate with serum proteins in solution and bind to the cell surface as a single anionic complex. Displacement of serum proteins from the nanoparticles was found to be protein dependent.
Doorley
Gerard W
GW
School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.
Payne
Christine K
CK
D000818:Animals; D001665:Binding Sites; D002412:Cations / Q000737:chemistry; D002417:Cattle; D002460:Cell Line; D002522:Chlorocebus aethiops; D005456:Fluorescent Dyes / Q000737:chemistry; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013499:Surface Properties
D002412:Cations; D005456:Fluorescent Dyes; D012710:Serum Albumin, Bovine