title: RNA editing in P transposable element read-through transcripts in Drosophila melanogaster.
abstract: RNA editing is proposed as a modulator of transcriptomes, but its biological impact has not been fully elucidated. In particular, its importance for transposable elements is controversial. We found RNA editing on antisense read-through transcripts of KP elements, one of the deletion derivatives of P transposable elements in Drosophila melanogaster. Three kinds of RNA editing were detected at 20 sites around the terminal inverted repeats (TIR); 15 A-to-G, four U-to-C, and one C-to-U conversions. A-to-G conversions are suggested to be attributed to A-to-I RNA editing on KP element RNAs, because inosine (I) in RNA is recognized as G by reverse transcriptase. TIRs were deduced to form dsRNAs as a putative target of ADAR. This is the first report of RNA editing on mobile elements of Drosophila.
authors.affiliation: Venture Laboratory, Kyoto Institute of Technology, Sakyo, Kyoto 606-8585, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Fukui
authors.forename: Masanobu
authors.initials: M
authors.lastname: Itoh
mesh_terms: D000818:Animals; D001483:Base Sequence; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D017393:RNA Editing; D014158:Transcription, Genetic
chemical_list: D004251:DNA Transposable Elements