title: Selective sensor for silver ions built from polyfluorophores on a DNA backbone.
abstract: To explore a new modular metal ion sensor design strategy, fluorophores and ligands were incorporated into short DNA-like oligomers. Compound 1 was found to function as a selective sensor for Ag(+) in aqueous buffer, where low micromolar concentrations of Ag(+) induce a red-shifted, turn-on fluorescence signal. Experiments with HeLa cells show that 1 can penetrate cells and yield a signal for intracellular Ag(+). This suggests a broadly applicable approach to developing sensors for a wide variety of cations.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States.
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Tan
authors.forename: Yin Nah
authors.initials: YN
authors.lastname: Teo
authors.forename: Eric T
authors.initials: ET
authors.lastname: Kool
mesh_terms: D002412:Cations / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*
chemical_list: D002412:Cations; D005456:Fluorescent Dyes; D012834:Silver; D004247:DNA