The yin and yang of polycomb repression in regenerating muscle.
Tumor necrosis factor-α (TNF-α) has complex effects on muscle regeneration. In this issue of Cell Stem Cell, Palacios et al. (2010) report that TNF-α-activated p38α kinase controls differentiation of muscle stem cells by promoting polycomb repressive complex 2 (PRC2) silencing of the Pax7 promoter.
Dobreva
Gergana
G
Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Ludwigstr. 43, Germany.
Braun
Thomas
T