title: [Incidence, risk factors and skin manifestations of post-thrombotic syndrome: a four-year follow-up of patients included in the EDITH study].
abstract: OBJECTIVE
  Despite appropriate therapy 10 to 100% of patients with deep vein thrombosis (DVT) of the lower limbs will develop post-thrombotic syndrome (PTS). The aim of this study was to evaluate the incidence of PTS in the EDITH cohort and to estimate the association between initial patients' characteristics and the risk of development of PTS.
  
  
  METHODS
  One hundred and eighty patients included in the EDITH study for a first event of DVT of the lower limbs without clinical signs of venous insufficiency were recalled 4 years after their initial thrombotic event. PTS was diagnosed according to the Villalta score.
  
  
  RESULTS
  Ninety-five patients (45 men, mean age 50.7 ± 16.9 years) were evaluated for PTS. Among them, 28.4% (95% CI 19.3-37.5) developed PTS but none had severe PTS. The most frequent clinical signs of PTS were varicose veins (59%), corona phlebectatica (48%), swelling leg (30%) and pigmented dermatitis (26%). No single risk factor was associated with PTS development (age, sex, BMI thrombophilia, etiology, localization, recurrence, symptomatic DVT and familial history of DVT).
  
  
  CONCLUSIONS
  PTS is a frequent disease. However, lack of uniformity of diagnosis criteria in the different studies does not make possible the estimation of PTS risk factors.
authors.affiliation: Université européenne de Bretagne, 29238 Brest cedex 3, France.
authors.forename: A
authors.initials: A
authors.lastname: Delluc
authors.forename: C
authors.initials: C
authors.lastname: Gouedard
authors.forename: L
authors.initials: L
authors.lastname: De Saint Martin
authors.forename: C
authors.initials: C
authors.lastname: Garcia
authors.forename: A-M
authors.initials: AM
authors.lastname: Roguedas
authors.forename: L
authors.initials: L
authors.lastname: Bressollette
authors.forename: L
authors.initials: L
authors.lastname: Misery
authors.forename: D
authors.initials: D
authors.lastname: Mottier
authors.forename: G
authors.initials: G
authors.lastname: Le Gal
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D054070:Postthrombotic Syndrome / Q000150:complications / Q000209:etiology*; D012307:Risk Factors; D012727:Sex Characteristics; D012871:Skin Diseases / Q000453:epidemiology* / Q000209:etiology; D014648:Varicose Veins / Q000175:diagnosis / Q000209:etiology; D020246:Venous Thrombosis / Q000150:complications