Negative regulation of autophagy.
Autophagy is an evolutionarily conserved catabolic process that involves the invagination and degradation of cytoplasmic components through an autophagosomelysosome track. Autophagy functions as a quality control of cellular milieu and is implicated in a wide variety of pathological conditions. However, excessive or imbalanced autophagic flux may also be associated with cellular toxicity and may potentially contribute to the development of pathological conditions. Just as all membrane trafficking systems need to constantly strike a balance in their level of activation and inhibition to ensure proper spatial and temporal delivery of their cargo, autophagy must also be tightly regulated. Here, we provide an overview of the current knowledge regarding the negative regulation of mammalian autophagy in an effort to understand its physiological relevance and potential clinical importance.
Liang
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Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA. chengyu.liang@usc.edu
D000818:Animals; D001343:Autophagy; D000071187:Autophagy-Related Protein 5; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism; D002154:Calpain / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
C495773:Atg5 protein, mouse; D000071187:Autophagy-Related Protein 5; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D008869:Microtubule-Associated Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D058570:TOR Serine-Threonine Kinases; D010744:Phosphoric Monoester Hydrolases; C061816:phosphatidylinositol-3-phosphatase; D002154:Calpain