aMAGEing new players enter the RING to promote ubiquitylation.
The MAGE proteins are best known as curious tumor-specific antigens. However, Doyle et al. (2010) reveal that MAGE proteins interact with RING proteins to promote ubiquitylation which provides important new insights into the physiological and pathological functions of this enigmatic family of proteins.
Espantman
Kristen C
KC
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037-1099, USA.
O'Shea
Clodagh C
CC