title: [Tumors of the pineal region: retrospective study of 40 cases].
abstract: BACKGROUND
  the tumours of the pineal region are rare brain tumours, most common in children and characterized by a large clinical and histologic polymorphism.
  
  
  OBJECTIVE
  to assess the outcome and prognostic factors of 40 patients with primitive pineal region tumours treated at the department of radiotherapy of Salah Azaiz institute.
  
  
  METHODS
  between January 1977 and December 2000, 40 patients received radiotherapy. There were 22 adults and 18 children (age < 16 years). The mean age was 20.4 years and sex ratio was 2.07. Histologic diagnosis was confirmed in 11 cases; 16 patients had a CT evaluation after 20 Gy radiotherapy and in 13 cases diagnosis was performed with CT aspects ± germinal tumour markers. Target volume varied; 10 had craniospinal irradiation, 16 had local irradiation and 14 had whole brain irradiation with a boost at the tumour bed. Chemotherapy was proposed for metastases and recurrent diseases.
  
  
  RESULTS
  survival rates were 87% at 2 years and 74, 5% at 5 years. For children, survival rates were 88% at 2 and 4 years. Eight patients (20%) failed locally and 5 patients (12.5%) had metastasis. Age, performance status and large fields of radiotherapy seem to be associated with prognosis and survival.
  
  
  CONCLUSIONS
  Pineal tumours and especially germinal tumours are chemosensitive and radiosensitive, care of these tumours is multidisciplinary involving surgery, chemotherapy and radiotherapy. From our study and a review of the literature, we tried to find a therapeutic strategy for tumours of the pineal region.
authors.affiliation: Service de Radiothérapie Carcinologique, Institut Salah Azaiz, Tunis.
authors.forename: Chiraz Nasr
authors.initials: CN
authors.lastname: Ben Ammar
authors.forename: Dorra
authors.initials: D
authors.lastname: Mnif
authors.forename: Bacem
authors.initials: B
authors.lastname: Belghith
authors.forename: Lotfi
authors.initials: L
authors.lastname: Kochbati
authors.forename: Hatem
authors.initials: H
authors.lastname: Frikha
authors.forename: Walid
authors.initials: W
authors.lastname: Gargouri
authors.forename: Mounir
authors.initials: M
authors.lastname: Besbes
authors.forename: Mansour
authors.initials: M
authors.lastname: Ben Abdallah
authors.forename: Mongi
authors.initials: M
authors.lastname: Maalej
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000401:mortality* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D010870:Pineal Gland / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult