title: The quadriga effect revisited: designing a "safety incision" to prevent tendon repair rupture and gap formation in a canine model in vitro.
abstract: Loss of experimental animals due to tendon repair failure results in the need for additional animals to complete the study. We designed a relief proximal to the flexor digitorum profundus (FDP) tendon repair site to serve as a "safety incision" to prevent repair site ruptures and maximize safety incision-to-suture strength. The FDP tendons were dissected in 24 canine forepaws. The 2nd and 5th tendons were lacerated at the proximal interphalangeal joint level and sutured using a modified Kessler technique and peripheral running suture. Tendon width was measured where the FDP tendon separates into each individual digit and a safety incision, equal to the 2nd and 5th tendon widths, was performed 3, 4, or 5 mm (Groups 1, 2, and 3) proximal to the separation. The tendons were pulled at a rate of 1 mm/s until either the "safety incision" ruptured or the repair failed. There was no gap formation at the repair site in Groups 1 and 2. However, all Group 3 tendons failed by repair site rupture with the safety incision intact. An adequate safety incision to protect repair gap and rupture and maintain tendon tension for the FDP animal model should be about 4 mm from where the FDP tendon separates.
authors.affiliation: Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
authors.forename: Hugo
authors.initials: H
authors.lastname: Giambini
authors.forename: Jun
authors.initials: J
authors.lastname: Ikeda
authors.forename: Peter C
authors.initials: PC
authors.lastname: Amadio
authors.forename: Kai-Nan
authors.initials: KN
authors.lastname: An
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000818:Animals; D004285:Dogs; D023421:Models, Animal; D011183:Postoperative Complications / Q000517:prevention & control; D012421:Rupture / Q000517:prevention & control; D013710:Tendons / Q000601:surgery*; D013718:Tensile Strength