title: An application of Ag(III) complex chemiluminescence system for the determination of enoxacin in capsule and biological fluid.
abstract: Ag(III) complex chemiluminescence (CL) system was applied for the determination of enoxacin (ENX). The CL conditions of [Ag(HIO(6))(2)](5-)-H(2)SO(4)-ENX systems without any luminescence reagent were investigated and optimized. Under the optimized conditions, the CL intensity was proportional to the concentration of ENX in the range from 6.6 × 10(-5) to 3.3 × 10(-3) g/L. The limit of detection (s/n = 3) was 2.0 × 10(-5) g/L. The recovery of ENX from the spiked pharmaceutical preparations was in the range of 82.9-108% with a relative standard deviation of 1.9-3.0%. For spiked serum and urine samples the recovery of ENX was in the range of 83.7-110% with a relative standard deviation of 1.1-2.8%. The proposed method was applied successfully to the determination of the drug in capsule, serum and urine samples.
authors.affiliation: College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding, 071002, China.
authors.forename: Peiyun
authors.initials: P
authors.lastname: Chen
authors.forename: Hanwen
authors.initials: H
authors.lastname: Sun
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis*; D001826:Body Fluids / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry*; D015365:Enoxacin / Q000032:analysis*; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D018030:Silver Compounds / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D002214:Capsules; D018030:Silver Compounds; D015365:Enoxacin