title: Interactions between giant unilamellar vesicles and charged core-shell magnetic nanoparticles.
abstract: This work combined two tools, giant unilamellar vesicles (GUVs) and core-shell magnetic nanoparticles (CSMNs), to develop a simplified model for studying interactions between the cell membrane and nanoparticles. We focused on charged functionalized CSMNs that can be either cationic or anionic. Using optical, electron, and confocal microscopy, we found that giant vesicle-nanoparticle interactions did not result from a simple electrostatic phenomenon because cationic CSMNs tended to bind to positively charged bilayers, whereas anionic CSMNs remained inert.
authors.affiliation: UPMC University of Paris 06-CNRS-ESPCI Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Laurencin
authors.forename: Thomas
authors.initials: T
authors.lastname: Georgelin
authors.forename: Bernard
authors.initials: B
authors.lastname: Malezieux
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Siaugue
authors.forename: Christine
authors.initials: C
authors.lastname: Ménager
mesh_terms: D002462:Cell Membrane / Q000737:chemistry; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D055620:Optical Phenomena; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D053835:Unilamellar Liposomes