Ionic liquids in oligosaccharide synthesis: towards mucin-type glycan probes.
The present article provides an overview on mucins and their role in biological processes, while aiming to familiarize readers with the current tools available for the synthesis of structurally defined mucin-type glycan probes including the advantages and potential applications of using ionic liquids in the synthesis of this important class of oligosaccharides. Furthermore, we also highlight recent developments in glycoarray technology that can enable high-sensitivity and high-throughput analysis of this important class of protein-carbohydrate interactions.
Galan
M Carmen
MC
Department of Chemistry, University of Bristol, Bristol BS8 1TS, UK. M.C.Galan@bristol.ac.uk
Corfield
Anthony P
AP
D052578:Ionic Liquids / Q000737:chemistry*; D008956:Models, Chemical; D009077:Mucins / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*
D052578:Ionic Liquids; D009077:Mucins; D009844:Oligosaccharides; D011134:Polysaccharides