Efficient Pd-catalyzed amination reactions for heterocycle functionalization.
The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The generality of these simple and efficient procedures is demonstrated through the synthesis of a wide variety of structural types.
Henderson
Jaclyn L
JL
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge Massachusetts 02139, USA.
Buchwald
Stephen L
SL
D000586:Amination; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D006571:Heterocyclic Compounds; D008024:Ligands; D010165:Palladium