The aging kidney: structural changes.
A number of structural changes occur in the kidney with aging. The aging kidney is characterized by loss of renal mass, arterial sclerosis, arteriolar hyalinosis, an increased number of sclerotic glomeruli, loss of tubules and interstitial fibrosis. The pathogenesis of aging-associated structural changes is not completely understood. Both genetic background and hemodynamic factors have been associated with progression of age-related morphological changes. The structural changes of aging kidney are nonspecific and can be seen in many conditions, including diabetes and hypertension, and, as such, arterionephrosclerosis of aging is a diagnosis of exclusion.
Pannarale
Giovanni
G
"Bonomo" Hospital, Andria, Italy. g.pannarale@libero.it
Carbone
Raffaella
R
Del Mastro
Giuseppe
G
Gallo
Carmela
C
Gattullo
Vincenzo
V
Natalicchio
Luigi
L
Navarra
Antonino
A
Tedesco
Agostino
A
D000367:Age Factors; D000375:Aging / Q000473:pathology*; D000818:Animals; D016922:Cellular Senescence; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000473:pathology / Q000503:physiopathology; D007684:Kidney Tubules / Q000473:pathology / Q000503:physiopathology; D012077:Renal Artery / Q000473:pathology / Q000503:physiopathology; D012079:Renal Circulation; D012307:Risk Factors