title: Simultaneous examination of tear film break-up and the lipid layer of the human eye: a novel model eye for time course simulation of physiologic tear film behavior (Part 2).
abstract: This article describes a model eye created to mimic the three-layered human tear-film. The model replicates the properties of the mucin, liquid and lipid layer as well as the time-course behavior including blinking process and tear film break-up for measurements with the tear film sensor described in Part 1. The setup basically consists of a sphere that is moistened by a dilution of tear film substitute. Therefore, the time point of the first break-up strongly depends on the consistency of the dilution. By means of an integrated heater, the evaporation rate of the artificial tear-film can be increased. To illustrate the applicability of the model eye, exemplary images during tear-film simulation, taken with and without using the heater, are shown. All images were captured by the sensor. Results and other potential applications are briefly discussed.
authors.affiliation: Medical Optics at the Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany. stefan.arnold@imp.uni-erlangen.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Arnold
authors.forename: Holger
authors.initials: H
authors.lastname: Bruenner
authors.forename: Achim
authors.initials: A
authors.lastname: Langenbucher
mesh_terms: D015374:Biosensing Techniques; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008055:Lipids / Q000502:physiology*; D009799:Ocular Physiological Phenomena; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D013666:Tears / Q000502:physiology*
chemical_list: D008055:Lipids; D009883:Ophthalmic Solutions