title: Paraneoplastic Clostridium septicum infection of a total knee arthroplasty.
abstract: We describe a case of a well-functioning total knee arthroplasty acutely infected with Clostridium septicum. This is the first reported infection of a prosthetic joint with this organism. A search for the source of this infection uncovered a colonic malignancy. This organism is highly associated with gastrointestinal malignancy, and appropriate investigation should be carried out when it is discovered. The importance of full anaerobic bacterial identification by the microbiology laboratory is underscored by this case.
authors.affiliation: Concordia Joint Replacement Group, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Colin D C
authors.initials: CD
authors.lastname: Burnell
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Turgeon
authors.forename: David R
authors.initials: DR
authors.lastname: Hedden
authors.forename: Eric R
authors.initials: ER
authors.lastname: Bohm
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee / Q000295:instrumentation*; D003015:Clostridium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D052557:Clostridium septicum / Q000302:isolation & purification*; D003110:Colonic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000382:microbiology*; D020370:Osteoarthritis, Knee / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents