Controlled attenuation parameter (CAP): a novel VCTE™ guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes.
There is a need for noninvasive methods to detect liver steatosis, which can be a factor of liver fibrosis progression. This work aims to evaluate a novel ultrasonic controlled attenuation parameter (CAP) devised to target, specifically, liver steatosis using a sophisticated process based on vibration control transient elastography (VCTE™). CAP was first validated as an estimate of ultrasonic attenuation at 3.5 MHz using Field II simulations and tissue-mimicking phantoms. Performance of the CAP was then appraised on 115 patients, taking the histological grade of steatosis as reference. CAP was significantly correlated to steatosis (Spearman ρ = 0.81, p < 10(-16)). Area under receiver operative characteristic (ROC) curve (AUC) was equal to 0.91 and 0.95 for the detection of more than 10% and 33% of steatosis, respectively. Furthermore, results show that CAP can efficiently separate several steatosis grades. These promising results suggest that CAP is a noninvasive, immediate, objective and efficient method to detect and quantify steatosis.
Sasso
Magali
M
R&D Department, Echosens, Paris, France. magali.sasso@echosens.com
Beaugrand
Michel
M
de Ledinghen
Victor
V
Douvin
Catherine
C
Marcellin
Patrick
P
Poupon
Raoul
R
Sandrin
Laurent
L
Miette
Véronique
V
D000465:Algorithms; D019540:Area Under Curve; D002908:Chronic Disease; D015331:Cohort Studies; D018450:Disease Progression; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D019047:Phantoms, Imaging; D010865:Pilot Projects; D012372:ROC Curve; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric