Polyoma virus-associated progressive multifocal leukoencephalopathy after renal transplantation: regression following withdrawal of mycophenolate mofetil.
The 2008-released FDA safety report described a potential association between use of MMF and progressive multifocal leukoencephalopathy. We here report the case of an 11-yr-old kidney transplanted boy suffering from PML who showed rapid improvement parallel to withdrawal of MMF. This case contributes to the increasing knowledge on side effects of MMF treatment in children.
Weber
Sven C
SC
Department of Pediatric Nephrology, Charité, Universitätsmedizin, Berlin, Germany. sven.weber@charite.de
Uhlenberg
Birgit
B
Raile
Klemens
K
Querfeld
Uwe
U
Müller
Dominik
D
D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000235:genetics / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology / Q000379:methods; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology / Q000821:virology*; D008297:Male; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011120:Polyomavirus / Q000276:immunology*; D027601:Polyomavirus Infections / Q000150:complications / Q000276:immunology; D018570:Risk Assessment; D014181:Transplantation Immunology / Q000187:drug effects; D014412:Tumor Virus Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D028761:Withholding Treatment
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid