title: Rising incidence of pancreatic cancer in France.
abstract: OBJECTIVE
  Time trends in the incidence of pancreatic cancer vary considerably between countries. The aim of this study was to provide time trends in incidence during a 25-year period in a well-defined French population.
  
  
  METHODS
  The cancer registry in Burgundy (France) was used to study time trends between 1981 and 2005 by sex, age, subsite, and histology. They were analyzed using an age-period cohort model.
  
  
  RESULTS
  Age-standardized incidence rates increased from 5.7 (1981-1985) to 7.9 per 100,000 (2001-2005) in men and from 2.6 to 4.6 in women. The mean percentage of variation by the 5-year period was +9.9% (P < 0.001, 95% confidence interval, 6.2%-13.6%) and +13.4% (P = 0.004, 95% confidence interval, 9.4%-17.5%), respectively. The increase in incidence was higher for cancers of the tail and corpus than for cancers of the head of pancreas and for malignant pancreatic endocrine tumors than for adenocarcinomas. The cumulative risk of developing a pancreatic cancer rose from 0.51% for men born in 1900 to 1.13% for those born in 1950. It was 0.34% and 0.55% for women, respectively.
  
  
  CONCLUSIONS
  The incidence of pancreatic cancer has increased sharply in France both by period and by birth cohort. Etiological studies are required to explain the increase in the incidence.
authors.affiliation: Registre Bourguignon des Cancers Digestifs, Centre Hospitalier Universitaire de Dijon, National Institute for Health and Medical Research, and Université de Bourgogne, Dijon, France. Anne-Marie.Bouvier@u-bourgogne.fr
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bouvier
authors.forename: Mathilde
authors.initials: M
authors.lastname: David
authors.forename: Valérie
authors.initials: V
authors.lastname: Jooste
authors.forename: Marion
authors.initials: M
authors.lastname: Chauvenet
authors.forename: Côme
authors.initials: C
authors.lastname: Lepage
authors.forename: Jean
authors.initials: J
authors.lastname: Faivre
mesh_terms: D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data*; D012307:Risk Factors; D012737:Sex Factors