title: Enamides accessed from aminothioesters via a Pd(0)-catalyzed decarbonylative/β-hydride elimination sequence.
abstract: A facile synthesis of various enamides from aminothioesters via a palladium(0)-catalyzed decarbonylation/β-hydride elimination is reported. This protocol was applied to mercaptopyridyl C-terminal modified peptides for the generation of enamides without epimerization at stereogenic centers.
authors.affiliation: Center of Insoluble Protein Structures (InSpin), Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C., Denmark.
authors.forename: Geanna K
authors.initials: GK
authors.lastname: Min
authors.forename: Dácil
authors.initials: D
authors.lastname: Hernández
authors.forename: Anders T
authors.initials: AT
authors.lastname: Lindhardt
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D000596:Amino Acids; D001688:Biological Products; D004952:Esters; D013438:Sulfhydryl Compounds; D010165:Palladium; D006859:Hydrogen