Hastifolins A-G, antifeedant neo-clerodane diterpenoids from Scutellaria hastifolia.
From the aerial parts of Scutellaria hastifolia, family Lamiaceae (Labiatae), seven neo-clerodane diterpenoids (hastifolins A-G) were isolated. The products are similar to the known scuteparvin and are characterized by being trans-cinnamoyl derivatives. Structures and stereochemistry were determined by intensive NMR investigation. Six of the products form three pairs of epimers at C-13. Hastifolins A-C showed significant antifeedant activity.
Raccuglia
Rosa Angela
RA
Dipartimento di Chimica Organica, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
Bellone
Gabriella
G
Loziene
Kristina
K
Piozzi
Franco
F
Rosselli
Sergio
S
Maggio
Antonella
A
Bruno
Maurizio
M
Simmonds
Monique S J
MS
D000818:Animals; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031363:Scutellaria / Q000737:chemistry*; D018411:Spodoptera / Q000187:drug effects*
D045785:Diterpenes, Clerodane