title: Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum.
abstract: OBJECTIVE
  We report the clinicopathologic features of a solitary fibrous tumor (SFT) having undergone malignant transformation and being intimately associated with a WHO Grade II astrocytoma.
  
  
  METHODS
  A 7-month old patient presented with delayed motor development and hydrocephalus.
  
  
  METHODS
  Histologic and immunocytologic methods were applied in the study of the tumors. Resection was initially employed and the SIOP protocol employing vincristine and carboplatin was applied upon tumor recurrence.
  
  
  CONCLUSIONS
  The biologic basis for the association of SFT and astrocytoma is unknown. The complex lesion differs substantially from WHO Grade IV gliosarcoma and from gliofibroma, lesions in which the disparate elements are linked by metaplasia. Indeed, it may represent a collision tumor. Lastly, induction of the glioma by the solitary fibrous tumor, a mechanism invoked to explain the poorly understood "sarcoglioma," deserves consideration.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: López
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: C
authors.initials: C
authors.lastname: Giannini
authors.forename: S H
authors.initials: SH
authors.lastname: Torp
mesh_terms: D001254:Astrocytoma / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D015897:Comorbidity; D006801:Humans; D007223:Infant; D008297:Male; D054364:Solitary Fibrous Tumors / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology