Association of facial skin aging and vitamin D levels in middle-aged white women.
To investigate the relationship between UV-induced skin photodamage and 25(OH) vitamin D levels, we performed a cross-sectional study in 45 female subjects aged >40. Menopausal status, smoking status, skin cancer history, oral supplement use, and season of blood draw were recorded and serum 25(OH)D measured. A single-blinded, dermatologist evaluated standardized digital facial images for overall photodamage, erythema/telangiectasias, hyperpigmentation, number of lentigines, and wrinkling. Adjusting for age and season of blood collection, women with lower photodamage scores were associated with a 5-fold increased odds of being vitamin D insufficient (OR 5.0, 95% CI: 1.1, 23). Low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling were also significantly associated with vitamin D insufficiency. Our results suggest an association between skin aging and 25(OH)D levels.
Chang
Anne Lynn S
AL
Department of Dermatology, Stanford University School of Medicine, 450 Broadway, Pavilion C, MC 5334, Redwood City, CA 94305, USA.
Fu
Teresa
T
Amir
Omar
O
Tang
Jean Y
JY
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005145:Face; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D015595:Skin Aging / Q000502:physiology*; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology; D012880:Skin Pigmentation / Q000502:physiology; D013472:Sunlight / Q000009:adverse effects; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*; D044465:White People / Q000706:statistics & numerical data*
D014807:Vitamin D