title: Application of subepithelial connective tissue graft with or without enamel matrix derivative for root coverage: a split-mouth randomized study.
abstract: The primary aim of this randomized clinical investigation was to evaluate gingival recession defects treated by a coronally advanced flap and sub-epithelial connective tissue graft (SCTG) with or without enamel matrix derivative (EMD). Twelve patients with Miller's class III buccal recession defects of ≥2.0 mm in similar contra lateral sites were included in this split-mouth randomized study. Test sites were treated with SCTG plus EMD while control sites received SCTG only. At baseline, 6 months and 12 months, clinical parameters such as recession level (RL), probing depth (PD), clinical attachment level (CAL), and apico-cervical width of keratinized tissue (KT) were determined. A P value <0.05 was considered significant. Compared to the baseline and based on paired t tests, both groups had significant improvement in all the clinical parameters. However, the test group showed better results in RL (P = 0.046) and CAL (P = 0.023) at 6 months. At 12 months, the test group demonstrated better results in RL (P = 0.01), PD (P = 0.017) and CAL (P = 0.001). Only the KT results were not significantly different between groups at both 6 and 12 months (P = 0.708) and (P = 0.570), respectively. The present study demonstrated the benefit of adding EMD to SCTG for root coverage in Miller's class III buccal gingival recession defects after 12 months. (J Oral Sci 52, 463-471, 2010).
authors.affiliation: Department of Periodontology, Faculty of Dentistry, São Leopoldo Mandic Dental Research Center, Campinas, SP, Brazil. phenriques@mpc.com.br
authors.forename: Paulo S G
authors.initials: PS
authors.lastname: Henriques
authors.forename: André A
authors.initials: AA
authors.lastname: Pelegrine
authors.forename: Ana A
authors.initials: AA
authors.lastname: Nogueira
authors.forename: Mônica M
authors.initials: MM
authors.lastname: Borghi
mesh_terms: D000328:Adult; D003238:Connective Tissue / Q000637:transplantation*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005889:Gingival Recession / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins