title: A retrospective analysis of obstetric patients with idiopathic thrombocytopenic purpura: a single center study.
abstract: Idiopathic thrombocytopenic purpura (ITP) commonly affects women of childbearing age. We studied the clinical characteristics of pregnant women with ITP to estimate their risks of bleeding. A retrospective chart review was performed for all obstetric patients with ITP who had delivery at our hospital, from 1 March 2000 to 31 March 2008. Twenty women with ITP delivered 24 children in 23 pregnancies. In all, eight women were treated with corticosteroid during their pregnancy period, and there was only one non-responder. There was no correlation between the maternal platelet count and the amount of blood loss at delivery. Two infants were revealed to have had platelet counts lower than 30 × 10⁹/L, and were treated with high-dose IV IgG. One of them also received corticosteroid therapy. There was no relationship between maternal platelet count at delivery and infant platelet count at birth. Overall, no serious bleeding event was seen in either of the mothers or infants. For most women with ITP, pregnancy is uncomplicated, and even those with severe thrombocytopenia during pregnancy have good outcomes when under the strict care of a hematologist and gynecologist.
authors.affiliation: Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan. richmond@wb3.so-net.ne.jp
authors.forename: Atsuko
authors.initials: A
authors.lastname: Fujita
authors.forename: Rika
authors.initials: R
authors.lastname: Sakai
authors.forename: Shiro
authors.initials: S
authors.lastname: Matsuura
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamamoto
authors.forename: Rika
authors.initials: R
authors.lastname: Ohshima
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Mika
authors.initials: M
authors.lastname: Okuda
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Shin
authors.initials: S
authors.lastname: Fujisawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D036861:Delivery, Obstetric; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000188:drug therapy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood* / Q000188:drug therapy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones