title: Mapping anterior temporal lobe language areas with fMRI: a multicenter normative study.
abstract: Removal of the anterior temporal lobe (ATL) is an effective surgical treatment for intractable temporal lobe epilepsy but carries a risk of language and verbal memory deficits. Preoperative localization of functional zones in the ATL might help reduce these risks, yet fMRI protocols in current widespread use produce very little activation in this region. Based on recent evidence suggesting a role for the ATL in semantic integration, we designed an fMRI protocol comparing comprehension of brief narratives (Story task) with a semantically shallow control task involving serial arithmetic (Math task). The Story > Math contrast elicited strong activation throughout the ATL, lateral temporal lobe, and medial temporal lobe bilaterally in an initial cohort of 18 healthy participants. The task protocol was then implemented at 6 other imaging centers using identical methods. Data from a second cohort of participants scanned at these centers closely replicated the results from the initial cohort. The Story-Math protocol provides a reliable method for activation of surgical regions of interest in the ATL. The bilateral activation supports previous claims that conceptual processing involves both temporal lobes. Used in combination with language lateralization measures, reliable ATL activation maps may be useful for predicting cognitive outcome in ATL surgery, though the validity of this approach needs to be established in a prospective surgical series.
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jbinder@mcw.edu
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Binder
authors.forename: William L
authors.initials: WL
authors.lastname: Gross
authors.forename: Jane B
authors.initials: JB
authors.lastname: Allendorfer
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bonilha
authors.forename: Jessica
authors.initials: J
authors.lastname: Chapin
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Edwards
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Grabowski
authors.forename: John T
authors.initials: JT
authors.lastname: Langfitt
authors.forename: David W
authors.initials: DW
authors.lastname: Loring
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Lowe
authors.forename: Katherine
authors.initials: K
authors.lastname: Koenig
authors.forename: Paul S
authors.initials: PS
authors.lastname: Morgan
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Ojemann
authors.forename: Christopher
authors.initials: C
authors.lastname: Rorden
authors.forename: Jerzy P
authors.initials: JP
authors.lastname: Szaflarski
authors.forename: Madalina E
authors.initials: ME
authors.lastname: Tivarus
authors.forename: Kurt E
authors.initials: KE
authors.lastname: Weaver
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D032882:Comprehension / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000502:physiology*; D055815:Young Adult