title: Insecticidal potency of novel compounds on multiple insect species of medical and veterinary importance.
abstract: BACKGROUND
  Vector-borne diseases continue to present significant threats to human, animal and plant health. Mosquitoes, houseflies, sand flies and stable flies are well-known vectors of several human and animal pathogens. The toxicity of selected semiochemicals with molecular structures indicative of insecticidal activity was determined against these insect species with the aim of developing novel insecticides toxic to multiple insect species.
  
  
  RESULTS
  Three semiochemicals, namely beta-damascone, cyclemone A and melafleur, showed remarkable toxicity to three mosquitoes, Aedes aegypti L., Ae. albopictus (Skuse) and Anopheles quadrimaculatus Say, the housefly, Musca domestica L., the stable fly, Stomoxys calcitrans L., and the sand fly, Lutzomyia shannoni (Dyar). The chemicals were equally toxic to several field-collected permethrin-tolerant housefly strains. When formulated as 500 mL L(-1) emulsifiable concentrates, the chemicals demonstrated stability and toxicity on filter paper and camouflage military fabrics, with persistence up to 8 days under laboratory conditions. The chemicals were equally effective under field conditions when evaluated on unpainted plywood panels, although a higher dosage was required under field conditions to achieve similar efficacy.
  
  
  CONCLUSIONS
  Laboratory quantification of LC(50) values and field efficacy of three semiochemicals as formulated compounds on mosquitoes, houseflies, stable flies and sand flies showed that these semiochemicals could serve as potent insecticides for multiple insect species.
authors.affiliation: Entomology and Nematology Department, University of Florida, Gainesville, FL 32611-0620, USA. pkaufman@ufl.edu
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Kaufman
authors.forename: Rajinder S
authors.initials: RS
authors.lastname: Mann
authors.forename: Jerry F
authors.initials: JF
authors.lastname: Butler
mesh_terms: D000330:Aedes; D000818:Animals; D000852:Anopheles; D004175:Diptera; D006793:Houseflies; D007300:Insect Control; D007303:Insect Vectors; D007305:Insecticide Resistance; D007306:Insecticides; D009117:Muscidae; D011576:Psychodidae
chemical_list: D007306:Insecticides