HIF hits Wnt in the stem cell niche.
Distinct stem-cell populations are known to reside in hypoxic niches during development and postnatal life. Hypoxia-inducible transcription factors (HIFs) directly regulate the Wnt/β-catenin pathway to ensure the maintenance of both adult and embryonic stem cells.
Kaufman
Dan S
DS
D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism; D000818:Animals; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000166:cytology / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*
D051793:Hypoxia-Inducible Factor 1; D051153:Wnt Proteins