title: Factors controlling cardiac neural crest cell migration.
abstract: Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting pharyngeal arch arteries. A subset of the cells continue migrating into the cardiac outflow tract where they will condense to form the aorticopulmonary septum. Cell signaling, extracellular matrix and cell-cell contacts are all critical for the initial migration, pauses, continued migration, and condensation of these cells. This review elucidates what is currently known about these factors.
authors.affiliation: Department of Pediatrics, Duke University, Durham, NC, USA. mlkirby@duke.edu
authors.forename: Margaret L
authors.initials: ML
authors.lastname: Kirby
authors.forename: Mary R
authors.initials: MR
authors.lastname: Hutson
mesh_terms: D000818:Animals; D002450:Cell Communication; D002465:Cell Movement / Q000235:genetics; D058750:Epithelial-Mesenchymal Transition; D005109:Extracellular Matrix / Q000378:metabolism; D005725:Ganglia, Autonomic / Q000196:embryology; D006321:Heart / Q000196:embryology* / Q000294:innervation; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D009432:Neural Crest / Q000166:cytology* / Q000378:metabolism; D010614:Pharynx / Q000098:blood supply / Q000196:embryology / Q000294:innervation
chemical_list: D047908:Intracellular Signaling Peptides and Proteins