[Expression and clinical significance of Xiap and Caspase-3 protien in primary epithelia ovarian cancer].
OBJECTIVE
To study the expression and clinical significance of Xiap, Caspase-3 protein in primary epithelia ovarian cancer.


METHODS
The Xiap and Caspase-3 were detected by immunohistochemical in 40 cases of epithelial ovarian cancer 20 cases of borderline ovarian tumor, 15 cases of benign ovarian tumor, and 15 normal ovarian tissues.


RESULTS
There were significantly different between the expression of Xiap in epithelial ovarian cancer, borderline ovarian tumor, benign ovarian tumor and normal ovarian tissues. The expression of Caspase-3 in epithelial ovarian cancer and borderline ovarian tumor was significantly lower than that in benign ovarian tumor and normal ovarian tissue (P<0.01). The expression of Xiap in epithelial ovarian cancer was related to clinc stage, pathological grade and living. The expression of caspase-3 in epithelial ovarian cancer was related to clinc stage and living (P<0.01).


CONCLUSIONS
The expressions of Xiap and Caspase-3 may be important roles for the formation and development of epithelia ovarian cancer. The expressions of Xiap and Caspase-3 are the poor prognostic factors in epithelial ovarian carcinomas.
Chen
Wei
W
Department of Gynecology and Obstetrics, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China. chen4096@hotmail.com
Peng
Ping
P
D000328:Adult; D000368:Aged; D053148:Caspase 3 / Q000235:genetics* / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000235:genetics* / Q000378:metabolism
D051636:X-Linked Inhibitor of Apoptosis Protein; D053148:Caspase 3