title: Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds.
abstract: Polyhydroxylated hybrid molecules have been synthesized using a protocol based on the regioselective acylation of the target compounds with activated dicarboxylic acids catalyzed by Novozym-435. The procedure implies that the mixed ester derivatives prepared and isolated from the first esterification step act as acylating agents in the second esterification step.
authors.affiliation: Istituto di Chimica del Riconoscimento Molecolare, C.N.R., Via Mario Bianco 9, 20131 Milan, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Magrone
authors.forename: Francesco
authors.initials: F
authors.lastname: Cavallo
authors.forename: Walter
authors.initials: W
authors.lastname: Panzeri
authors.forename: Daniele
authors.initials: D
authors.lastname: Passarella
authors.forename: Sergio
authors.initials: S
authors.lastname: Riva
mesh_terms: D055162:Biocatalysis; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D006878:Hydroxides / Q000138:chemical synthesis* / Q000378:metabolism; D008049:Lipase / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D006878:Hydroxides; C031356:hydroxide ion; C093667:Novozyme 435; D008049:Lipase