title: Hepcidin and disorders of iron metabolism.
abstract: The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. TGanz@mednet.ucla.edu
authors.forename: Tomas
authors.initials: T
authors.lastname: Ganz
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Nemeth
mesh_terms: D000375:Aging / Q000378:metabolism; D000740:Anemia / Q000378:metabolism; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism; D005260:Female; D022781:Hepatocytes / Q000378:metabolism; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000188:drug therapy / Q000378:metabolism*; D019266:Iron, Dietary / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D000098742:Ferroportin
chemical_list: D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; C578702:HAMP protein, human; C579599:Hamp protein, mouse; D064451:Hepcidins; D015850:Interleukin-6; D019266:Iron, Dietary; D014168:Transferrin; D000098742:Ferroportin; D007501:Iron