title: [Hyperbaric oxygenation in combined treatment of interstitial cystitis].
abstract: A total of 116 female patients with painful bladder syndrome/interstitial cystitis aged 32-78 years (mean age 56 +/- 2.4 years) entered the trial. They were divided into two groups according to treatment. Group 1 (n = 54) received 10-day combined conservative treatment consisting of antimicrobial drugs (if urinary infection was diagnosed), angioprotectors, mast cell activity stabilizers and bladder instillation with combined solution. Group 2 included 62 patients whose treatment included complex anti-inflammatory therapy in combination with HBO sessions (7-10 sessions in barochamber OKA-MT, 2.0 +/- 0.2 atm). Subjective (the disease course, pain intensity, 24-h and nocturnal pollakiuria, effective urine volume) and objective (microcirculation in the bladder wall) results were assessed. Dopplerograms revealed venous stagnation. Patients of group 2 had a persistent improvement of microcirculation in bladder mucosa as shown by better blood flow in the veins and arterioles. In group 1 the above improvement was less pronounced. Thus, HBO in combined treatment of interstitial cystitis improves treatment results and promotes long-term remission of the disease.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Pushkar'
authors.forename: A V
authors.initials: AV
authors.lastname: Zaĭtsev
authors.forename: A P
authors.initials: AP
authors.lastname: Gavrilenko
authors.forename: A B
authors.initials: AB
authors.lastname: Matsaev
authors.forename: G R
authors.initials: GR
authors.lastname: Kasian
authors.forename: K B
authors.initials: KB
authors.lastname: Kolontarev
authors.forename: R F
authors.initials: RF
authors.lastname: Farmanov
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D018856:Cystitis, Interstitial / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000098:blood supply / Q000503:physiopathology