Mechanisms of tubulointerstitial fibrosis.
The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even reverse fibrosis remains elusive. Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies. How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding.
Zeisberg
Michael
M
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. mzeisber@bidmc.harvard.edu
Neilson
Eric G
EG
D018450:Disease Progression; D004848:Epithelium / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D005355:Fibrosis; D020022:Genetic Predisposition to Disease; D006801:Humans; D009395:Nephritis, Interstitial / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D051437:Renal Insufficiency / Q000473:pathology / Q000503:physiopathology