title: Effects of parathyroid hormone on immune function.
abstract: Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis. Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells). The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to methodological heterogeneity of these studies: it used different PTH formulations (rat, bovine, and human), at different dosages and different incubating periods. In some of these studies, the lymphocytes were collected from uremic patients or animals, which renders the interpretation of the results problematic due to the effect of uremic toxins. Parathyroidectomy has been found to reverse the immunologic defect in patients with high PTH levels. Nonetheless, the clinical significance of these findings is unclear. Further studies are needed to define if PTH does have immunomodulatory effects.
authors.affiliation: Department of Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA. abdallah.geara@gmail.com
authors.forename: Abdallah Sassine
authors.initials: AS
authors.lastname: Geara
authors.forename: Mario R
authors.initials: MR
authors.lastname: Castellanos
authors.forename: Claude
authors.initials: C
authors.lastname: Bassil
authors.forename: Georgia
authors.initials: G
authors.lastname: Schuller-Levis
authors.forename: Eunkue
authors.initials: E
authors.lastname: Park
authors.forename: Marianne
authors.initials: M
authors.lastname: Smith
authors.forename: Michael
authors.initials: M
authors.lastname: Goldman
authors.forename: Suzanne
authors.initials: S
authors.lastname: Elsayegh
mesh_terms: D000818:Animals; D002417:Cattle; D006801:Humans; D056747:Immunomodulation; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D018016:Receptors, Parathyroid Hormone / Q000378:metabolism; D014511:Uremia / Q000276:immunology* / Q000378:metabolism
chemical_list: D010281:Parathyroid Hormone; D018016:Receptors, Parathyroid Hormone