title: Hydrogen protects vestibular hair cells from free radicals.
abstract: CONCLUSIONS
  Hydrogen gas effectively protected against the morphological and functional vestibular hair cell damage by reactive oxygen species (ROS).
  
  
  OBJECTIVE
  ROS are generally produced by oxidative stress. In the inner ear, ROS levels increase as a result of noise trauma and ototoxic drugs and induce damage. It is thus important to control ROS levels in the inner ear. The protective effects of hydrogen gas in cochlear hair cells have been reported previously.
  
  
  METHODS
  This study examined the effects of hydrogen gas on mouse vestibular hair cell damage by ROS using antimycin A.
  
  
  RESULTS
  In the group *exposed to hydrogen gas, vestibular hair cells were morphologically well preserved and their mechano-electrical transduction activities were relatively well maintained when compared with controls. Hydroxyphenyl fluorescein (HPF) fluorescence in vestibular tissue was also reduced by hydrogen gas.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kyoto University, Kyoto, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Taura
authors.forename: Yayoi S
authors.initials: YS
authors.lastname: Kikkawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000968:Antimycin A / Q000494:pharmacology*; D005452:Fluoresceins / Q000378:metabolism; D018069:Hair Cells, Vestibular / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006859:Hydrogen / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000502:physiology*; D011726:Pyridinium Compounds / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000494:pharmacology*
chemical_list: C520960:2-(6-(4'-hydroxy)phenoxy-3H-xanthen-3-on-9-yl)benzoic acid; D000900:Anti-Bacterial Agents; C073804:FM1 43; D005452:Fluoresceins; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds; D017382:Reactive Oxygen Species; D000968:Antimycin A; D006859:Hydrogen