title: Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemical deposition.
abstract: Hydroxyapatite (HA) coatings on titanium (Ti) substrates have attracted much attention owing to the combination of good mechanical properties of Ti and superior biocompatibility of HA. Incorporating silver (Ag) into HA coatings is an effective method to impart the coatings with antibacterial properties. However, the uniform distribution of Ag is still a challenge and Ag particles in the coatings are easy to agglomerate, which in turn affects the applications of the coatings. In this study, we employed pulsed electrochemical deposition to co-deposit HA and Ag simultaneously, which realized the uniform distribution of Ag particles in the coatings. This method was based on the use of a well-designed electrolyte containing Ag ions, calcium ions and l-cysteine, in which cysteine acted as the coordination agent to stabilize Ag ions. The antibacterial and cell culture tests were used to evaluate the antibacterial properties and biocompatibility of HA/Ag composite coatings, respectively. The results indicated the as-prepared coatings had good antibacterial properties and biocompatibility. However, an appropriate silver content should be chosen to balance the biocompatibility and antibacterial properties. Heat treatments promoted the adhesive strength and enhanced the biocompatibility without sacrificing the antibacterial properties of the HA/Ag coatings. In summary, this study provided an alternative method to prepare bioactive surfaces with bactericidal ability for biomedical devices.
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031 Sichuan, People's Republic of China. luxiong_2004@163.com
authors.forename: Xiong
authors.initials: X
authors.lastname: Lu
authors.forename: Bailin
authors.initials: B
authors.lastname: Zhang
authors.forename: Yingbo
authors.initials: Y
authors.lastname: Wang
authors.forename: Xianli
authors.initials: X
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
authors.forename: Shuxin
authors.initials: S
authors.lastname: Qu
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.forename: Fumio
authors.initials: F
authors.lastname: Watari
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Ding
authors.forename: Yang
authors.initials: Y
authors.lastname: Leng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D055664:Electrochemical Techniques; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D012834:Silver; D017886:Durapatite; D014025:Titanium