title: Association of facial skin aging and vitamin D levels in middle-aged white women.
abstract: To investigate the relationship between UV-induced skin photodamage and 25(OH) vitamin D levels, we performed a cross-sectional study in 45 female subjects aged >40. Menopausal status, smoking status, skin cancer history, oral supplement use, and season of blood draw were recorded and serum 25(OH)D measured. A single-blinded, dermatologist evaluated standardized digital facial images for overall photodamage, erythema/telangiectasias, hyperpigmentation, number of lentigines, and wrinkling. Adjusting for age and season of blood collection, women with lower photodamage scores were associated with a 5-fold increased odds of being vitamin D insufficient (OR 5.0, 95% CI: 1.1, 23). Low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling were also significantly associated with vitamin D insufficiency. Our results suggest an association between skin aging and 25(OH)D levels.
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, 450 Broadway, Pavilion C, MC 5334, Redwood City, CA 94305, USA.
authors.forename: Anne Lynn S
authors.initials: AL
authors.lastname: Chang
authors.forename: Teresa
authors.initials: T
authors.lastname: Fu
authors.forename: Omar
authors.initials: O
authors.lastname: Amir
authors.forename: Jean Y
authors.initials: JY
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005145:Face; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D015595:Skin Aging / Q000502:physiology*; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology; D012880:Skin Pigmentation / Q000502:physiology; D013472:Sunlight / Q000009:adverse effects; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D014807:Vitamin D