title: Evaluation of Escherichia coli cell response to antibiotic treatment by use of Raman spectroscopy with laser tweezers.
abstract: Laser tweezers Raman spectroscopy was used to detect the cellular response of Escherichia coli cells to penicillin G-streptomycin and cefazolin. Time-dependent intensity changes of several Raman peaks at 729, 1,245, and 1,660 cm(-1) enabled untreated cells and cells treated with the different antibiotic drugs to be distinguished.
authors.affiliation: Biophysics Graduate Group, University of California, Davis, Davis, California 95616, USA.
authors.forename: Tobias J
authors.initials: TJ
authors.lastname: Moritz
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Polage
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Taylor
authors.forename: Denise M
authors.initials: DM
authors.lastname: Krol
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Lane
authors.forename: James W
authors.initials: JW
authors.lastname: Chan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001431:Bacteriological Techniques / Q000379:methods*; D002437:Cefazolin / Q000494:pharmacology; D004926:Escherichia coli / Q000737:chemistry* / Q000187:drug effects* / Q000378:metabolism; D052898:Optical Tweezers; D010400:Penicillin G / Q000494:pharmacology; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013307:Streptomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin; D010400:Penicillin G; D013307:Streptomycin