title: Does sulfur-hexafluoride tamponade, as an adjunct to vitrectomy and internal-limiting-membrane peeling, suffice for the treatment of retinal detachment associated with macular hole?
abstract: OBJECTIVE
  To evaluate the efficacy of sulfur hexafluoride tamponade, as an adjunct to vitrectomy and internal-limiting-membrane peeling, for the treatment of retinal detachment (RD) associated with macular hole (MH).
  
  
  METHODS
  Our study was a retrospective interventional case series. We evaluated 9 phakic eyes of 9 consecutive patients with retinal detachment secondary to macular hole (MHRD) treated with 20-gauge (g) pars plana vitrectomy, which was followed with trypan blue-assisted internal-limiting-membrane peeling, fluid-air exchange, and 20% sulfur hexafluoride tamponade (SF(6)) gas exchange. All patients underwent optical coherence tomography, best-corrected visual acuity (BCVA) measurement, and dilated fundus examination with indentation, pre- and postoperatively.
  
  
  RESULTS
  The mean (± standard deviation) follow-up time was 13 ± 3 months (range 9-18). Postoperatively, all eyes demonstrated an attached retina, whereas MH closure was achieved in only 1 eye, and in a second eye after additional injection of gas and further posturing. The BCVA improved from 2.2 ± 0.4 logMAR (logarithm of the minimum angle of resolution) at baseline to 2.0 ± 0.5 logMAR at the end of follow-up (p = .05).
  
  
  CONCLUSIONS
  The failure in MH closure in most of our cases strengthens the view that short-term tamponade with SF(6) may not suffice for achieving MH closure, and either prolonged tamponade (with C(3)F(8) or silicone oil) or additional photocoagulation may be a better option for eyes with MHRDs. In addition, it is possible that intravitreal injection of gas might be an option for the treatment of persistent MHs after vitrectomy for MHRD, especially when the MH is small. Further studies are required to evaluate the above findings, although the implementation of large series studies remains a challenge because of the rarity of cases with MHRDs.
authors.affiliation: Department of Ophthalmology, University of Athens, Athens, Greece. igeorgalas@yahoo.com
authors.forename: Ilias
authors.initials: I
authors.lastname: Georgalas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Ladas
authors.forename: Petros
authors.initials: P
authors.lastname: Petrou
authors.forename: Eustratios
authors.initials: E
authors.lastname: Gotzaridis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Papaconstantinou
authors.forename: Alexandros
authors.initials: A
authors.lastname: Rouvas
authors.forename: Chryssanthi
authors.initials: C
authors.lastname: Koutsandrea
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D019773:Epiretinal Membrane / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D012167:Retinal Perforations / Q000150:complications / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D013459:Sulfur Hexafluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014821:Vitrectomy / Q000379:methods*
chemical_list: D013459:Sulfur Hexafluoride