Synthesis and preliminary anti-HIV activities of andrographolide derivatives.
Recent studies indicated that andrographolide was a potential anti-HIV therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their anti-HIV activities were evaluated in vitro. As compared with TI, compounds 5c, 5d and 5i showed moderate inhibitory activities on the cytopathic effect with TI above 10. Among the derivatives, compound 5i was the best one with TI > 51.
Wang
Bin
B
Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Ge
Liang
L
Huang
Wenlong
W
Zhang
Huibin
H
Qian
Hai
H
Li
Jing
J
Zheng
Yongtang
Y
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D004224:Diterpenes; C030419:andrographolide