title: Dual-focus therapeutic ultrasound transducer for production of broad tissue lesions.
abstract: In noninvasive high-intensity focused ultrasound (HIFU) treatment, formation of a large tissue lesion per sonication is desirable for reducing the overall treatment time. The goal of this study is to show the feasibility of enlarging tissue lesion size with a dual-focus therapeutic ultrasound transducer (DFTUT) by increasing the depth-of-focus (DOF). The proposed transducer consists of a disc- and an annular-type element of different radii of curvatures to produce two focal zones. To increase focal depth and to maintain uniform beamwidth of the elongated DOF, each element transmits ultrasound of a different center frequency: the inner element at a higher frequency for near field focusing and the outer element at a lower frequency for far field focusing. By activating two elements at the same time with a single transmitter capable of generating a dual-frequency mixed signal, the overall DOF of the proposed transducer may be extended considerably. A prototype transducer composed of a 4.1 MHz inner element and a 2.7 MHz outer element was fabricated to obtain preliminary experimental results. The feasibility the proposed technique was demonstrated through sound field, temperature and thermal dose simulations. The performance of the prototype transducer was verified by hydrophone measurements and tissue ablation experiments on a beef liver specimen. When several factors affecting the length and the uniformity of elongated DOF of the DFTUT are optimized, the proposed therapeutic ultrasound transducer design may increase the size of ablated tissues in the axial direction and, thus, decreasing the treatment time for a large volume of malignant tissues especially deep-seated targets.
authors.affiliation: NIH Resource Center for Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089-1111, USA. jongsjeo@usc.edu
authors.forename: Jong Seob
authors.initials: JS
authors.lastname: Jeong
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Cannata
authors.forename: K Kirk
authors.initials: KK
authors.lastname: Shung
mesh_terms: D004867:Equipment Design; D005240:Feasibility Studies; D006358:Hot Temperature; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation*