title: Expansion of human cord blood hematopoietic stem cells for transplantation.
abstract: A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture (Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically.
authors.affiliation: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
authors.forename: Song
authors.initials: S
authors.lastname: Chou
authors.forename: Pat
authors.initials: P
authors.lastname: Chu
authors.forename: William
authors.initials: W
authors.lastname: Hwang
authors.forename: Harvey
authors.initials: H
authors.lastname: Lodish
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods; D049109:Cell Proliferation; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D011687:Purines / Q000378:metabolism
chemical_list: D011687:Purines