title: The Macular Assessment Profile test - a new VDU-based technique for measuring the spatial distribution of the macular pigment, lens density and rapid flicker sensitivity.
abstract: The measurement of macular pigment optical density (MPOD) in the eye is often carried out using optical techniques based on heterochromatic flicker photometry (HFP). These require the use of two spectrally-narrow beams, one at the wavelength of maximum absorption of the macular pigment (MP) and the other in the long wavelength region of the visible spectrum where MP absorption is negligible. A new technique for the measurement of MPOD spatial profiles has been developed by overcoming the current shortcomings associated with the use of visual displays. The new Macular Assessment Profile (MAP) test makes use of a 'notch' filter and a photometric model to measure and compute the peak MPOD value. Two other useful parameters are also computed from the same measurements. These describe the subject's sensitivity to rapid flicker and the absorption of blue light by the lens. MPOD profiles, lens density, rapid flicker sensitivity, and red/green (RG) and yellow/blue (YB) colour thresholds were measured in 54 normal subjects aged 18-61 years. The results confirm previous findings on ageing effects and demonstrate the complete absence of correlation between MPOD and the subject's YB chromatic thresholds. In contrast, RG chromatic sensitivity improves with higher levels of MPOD.
authors.affiliation: Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, City University, Northampton Square, London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Barbur
authors.forename: E
authors.initials: E
authors.lastname: Konstantakopoulou
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez-Carmona
authors.forename: J A
authors.initials: JA
authors.lastname: Harlow
authors.forename: A G
authors.initials: AG
authors.lastname: Robson
authors.forename: J D
authors.initials: JD
authors.lastname: Moreland
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology / Q000523:psychology; D003118:Color Perception / Q000502:physiology; D003119:Color Perception Tests / Q000379:methods; D055253:Color Vision / Q000502:physiology*; D016288:Computer Terminals; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005425:Flicker Fusion; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008266:Macula Lutea / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010783:Photometry / Q000379:methods; D012168:Retinal Pigments / Q000032:analysis*; D012684:Sensory Thresholds / Q000502:physiology; D055815:Young Adult
chemical_list: D012168:Retinal Pigments