In obesity and weight loss, all roads lead to the mighty macrophage.
Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.
Red Eagle
Alex
A
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Chawla
Ajay
A
D052436:Adipose Tissue, White / Q000276:immunology*; D000818:Animals; D002465:Cell Movement; D006801:Humans; D008066:Lipolysis; D008264:Macrophages / Q000502:physiology*; D009765:Obesity / Q000276:immunology*; D015431:Weight Loss / Q000276:immunology*