Lipoglioblastoma: a lipidized glioma radiologically and histologically mimicking adipose tissue.
BACKGROUND
We report the case of a man with glioblastoma containing a component radiologically and histologically mimicking adipose tissue.


METHODS
A 48-year-old man recently complaining of headaches and difficulty with speech presented with a cystic peripherally enhancing left temporoparietal mass with focal intrinsically (precontrast) bright nodules in fluid attenuated inversion recovery and T1-weighted images similar to adipose tissue. Histologically, the enhancing component was classic glioblastoma, whereas the bright nodules comprised tumor cells that in aggregate closely resembled adipose tissue.


CONCLUSIONS
The case illustrates the extent to which lipidized central nervous system tumors of glial origin, or components thereof, can radiologically and histologically resemble adipose tissue. However, immunohistochemical staining and electron microscopy can eliminate diagnostic confusion.
Johnson
Michael W
MW
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Lin
Doris
D
Smir
Bassam N
BN
Burger
Peter C
PC
D000273:Adipose Tissue / Q000473:pathology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008064:Lipidoses / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011859:Radiography