title: Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males.
abstract: The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used to assess IR. The presence of MetS was defined according to the AHA/NHLBI criteria. The prevalence of MetS was 19.3%. The odds ratio of MetS for restrictive ventilatory pattern was 1.55 (95% confidence interval, 1.12-2.14), and that for obstructive ventilatory pattern was 1.39 (0.66-2.94) after adjustment for confounders. When subjects were divided in 4 groups according to quartiles of FVC or FEV(1) (% predicted [pred]), HOMA-IR significantly increased as the FVC or FEV(1) (% predicted [pred]) decreased. Individuals in the lowest FVC or FEV(1) quartile had the highest hs-CRP level. Prevalence of MetS increased as FVC or FEV(1) (% predicted [pred]) quartiles decreased. The abdominal obesity, hs-CRP and HOMA-IR were the independent predictors for the lowest FVC and FEV(1) (% predicted [pred]) even after adjustment for confounders. These results indicate that MetS, IR, and systemic inflammation are important risk factors for reduced lung function in nonsmoking Korean males.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Seong Yong
authors.initials: SY
authors.lastname: Lim
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005541:Forced Expiratory Volume / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D016017:Odds Ratio; D012123:Pulmonary Ventilation / Q000502:physiology*; D056910:Republic of Korea; D012129:Respiratory Function Tests; D012307:Risk Factors; D014797:Vital Capacity / Q000502:physiology
chemical_list: D007328:Insulin; D002097:C-Reactive Protein; D005947:Glucose