Long-range protein coupling mediated by critical low-energy modes of tubular lipid membranes.
We develop a theory of a resonant effect in protein-membrane coupling taking place in the vicinity of instabilities in tubular lipid membranes (TLMs) under longitudinal force and pressure difference constraints. Two critical low-energy modes defining the stability domain boundaries are found. We show that these modes mediate long-range TLM-protein coupling and interactions between absorbed proteins. Besides, TLM mechanical instabilities strongly influence protein desorption and protein cluster nucleation on TLMs. Model predictions can be tested over a large spectrum of mechanochemical conditions.
Monnier
Sylvain
S
Laboratoire de Physique Théorique et Astroparticules, CNRS, Université Montpellier II, Pl. E. Bataillon, 34095 Montpellier Cedex 5, France.
Rochal
Sergei B
SB
Parmeggiani
Andrea
A
Lorman
Vladimir L
VL
D001665:Binding Sites; D055119:Elastic Modulus; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D015388:Organelles / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013314:Stress, Mechanical; D013816:Thermodynamics
D008563:Membrane Lipids; D011506:Proteins