title: Simultaneous examination of tear film break-up and the lipid layer of the human eye: a novel sensor design (Part 1).
abstract: This article presents a non-invasive sensor setup for objective analysis of the pre-corneal human tear-film involving a time-resolved videokeratoscopy and simultaneous imaging of the lipid layer of the tear-film by a second CMOS-camera. This paper describes in detail the mechanical and optical design of the sensor setup, the realization of the entire illumination component with an integrated Placido grid projection, and the calculation of the image formation using the Placido grid. This concept is demonstrated here with a test subject in the full inter-blink period. All images were taken under physiological conditions. The sensor can assist the ophthalmologist in diagnosing Dry-Eye Syndrome. Results and other potential applications are discussed.
authors.affiliation: Medical Optics at the Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany. stefan.arnold@imp.uni-erlangen.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Arnold
authors.forename: Annette
authors.initials: A
authors.lastname: Walter
authors.forename: Timo
authors.initials: T
authors.lastname: Eppig
authors.forename: Holger
authors.initials: H
authors.lastname: Bruenner
authors.forename: Achim
authors.initials: A
authors.lastname: Langenbucher
mesh_terms: D001767:Blinking / Q000502:physiology*; D015352:Dry Eye Syndromes / Q000503:physiopathology; D005123:Eye / Q000033:anatomy & histology*; D006801:Humans; D008029:Lighting; D008055:Lipids / Q000032:analysis / Q000502:physiology; D009799:Ocular Physiological Phenomena; D012720:Severity of Illness Index; D013666:Tears / Q000502:physiology*
chemical_list: D008055:Lipids