Identifying tremor-related characteristics of basal ganglia nuclei during movement in the Parkinsonian patient.
Local field potential (LFP) and Electromyographic (EMG) signals were recorded from 12 Parkinsonian patients with tremor-dominant symptoms as they performed passive and voluntary movements. The LFP signals were categorised into episodes of tremorous and atremorous activity (identified through EMG power spectra), then divided into delta (2-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) frequency bands. Modulation of LFP oscillatory activity in these frequency bands were compared between the subthalamic nucleus (STN) and the globus pallidus internus (GPi) to determine if differential tremor-related characteristics were identifiable for either target. Our results suggest that such local characteristic activity is identifiable in the STN, and thus could be a target for initial development of a closed-loop demand driven stimulator device which capitalises on such activity to trigger stimulation, even during voluntary movement activity.
Burgess
Jonathan G
JG
School of Systems Engineering, University of Reading, UK. j.g.burgess@reading.ac.uk
Warwick
Kevin
K
Ruiz
Virginie
V
Gasson
Mark N
MN
Aziz
Tipu Z
TZ
Brittain
John-Stuart
JS
Stein
John
J
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000473:pathology*; D003627:Data Interpretation, Statistical; D046690:Deep Brain Stimulation; D004558:Electric Stimulation; D004569:Electroencephalography; D004576:Electromyography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D020531:Subthalamic Nucleus / Q000473:pathology; D014202:Tremor / Q000503:physiopathology