title: Synthesis and study of controlled release of ofloxacin from polyester conjugates.
abstract: New polymeric conjugates were prepared coupling ofloxacin to two-, three-, four and six-arm, star-shaped poly(ɛ-caprolactone) and polylactide. The homopolymers were synthesized via ring-opening polymerization of ɛ-caprolactone, l-lactide and rac-lactide in the presence of glycerol, penthaerythritol, dipentaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. The conjugates were characterized by GPC, MALDI-TOF MS, NMR, IR and viscosity methods. Content of Sn has been investigated in polymers by electrothermal atomic absorption spectrometry. Toxicity of monomers, initiators and polymers were evaluated with bacterial luminescence test and two protozoan assays. The in vitro release of ofloxacin from obtained conjugates in pH 7 was investigated.
authors.affiliation: Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wum.edu.pl
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Nałęcz-Jawecki
authors.forename: Wacław L
authors.initials: WL
authors.lastname: Kołodziejski
authors.forename: Piotr
authors.initials: P
authors.lastname: Goś
authors.forename: Karolina
authors.initials: K
authors.lastname: Zółtowska
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000633:toxicity; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D008163:Luminescent Measurements; D015242:Ofloxacin / Q000737:chemistry* / Q000633:toxicity; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013054:Spectrophotometry, Atomic; D018675:Toxicity Tests; D014783:Viscosity
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; C016240:polycaprolactone; C033616:poly(lactide); D015242:Ofloxacin