title: [An HGPRT defective mouse lung cancer cell line and its biological characteristics.].
abstract: BACKGROUND
  To provide antigenic cells suitable for cell fusion to preparing lung cancer vaccine.
  
  
  METHODS
  An HGPRT (hypoxanthine guanidine phosphoribosyl transferase)-defective cell line , ALA9702 , was gradually induced by 8-azaguanine (8-AG) from mouse lung cancer cell line , LA795 . The biological characteristics and carcinogenicity of ALA9702 cells have been appraised both in vivo and in vitro.
  
  
  RESULTS
  ALA9702 cells have been cultured over one year in medium containing 20mug/ml 8-AG, and maintained their biologic characteristics and carcinogenicity of the original cells , LA795 cells.
  
  
  CONCLUSIONS
  ALA9702 cell line presents as stabile HGPRT-defective mouse lung cancer cell. It will provide useful antigenic cells for establishment of effective specific lung cancer vaccine therapy.
authors.affiliation: Cancer Center and Cancer Institute of The First University Hospital , West China University of Medical Sciences , Chengdu 610041 , P. R. China.
authors.forename: P
authors.initials: P
authors.lastname: Lin
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Huang