[Preparation and characterization of curcumin polybutylcyanoacrylate nanoparticles].
OBJECTIVE
To prepare curcumin polybutylcyanoacrylate nanoparticles (Cur-PBCNs) and evaluate its characteristics.


METHODS
Cur-PBCNs were prepared by emulsion polymerization, and the formulation was optimized by L16 (4(3)) orthogonal design test with entrapment efficiency and drug loading as indices. In addition, its characteristics were investigated.


RESULTS
The nanoparticles were spherical in appearance under transmission electron microscope (TEM). The mean diameter of the nanoparticles was 93.8 nm, the mean entrapment efficiency was (50.4 +/- 2.2)%, the mean drug-loading was (33.5 +/- 0.9)% and the Zeta potential was -6.81 mV. The total drug release was 34.74% in 2 hours followed by a sustained release in vitro for Cur-PBCNs, and the in vitro release profile of the nanoparticles was fit for two phases kinetics equation: 100 - Q = 4.5235e(-0.1724t) + 4.1641e(-0.0114t).


CONCLUSIONS
The optimal Cur-PBCNs show good characteristics and sustained release character in vitro.
Zhu
Xiu-qing
XQ
College of Pharmacy, Shandong University, Jinan 250012, China.
Sun
Min
M
Zhu
Fan-ping
FP
Ding
Ting-ting
TT
Zhai
Ying-jie
YJ
Zhai
Guang-xi
GX
D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D004659:Enbucrilate / Q000008:administration & dosage / Q000737:chemistry*; D020939:Zingiber officinale / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D004337:Drug Carriers; D004655:Emulsions; D011092:Polyethylene Glycols; D004659:Enbucrilate; D003474:Curcumin