Mechanotransduction: a major regulator of homeostasis and development.
In nearly all aspects of biology, forces are a relevant regulator of life's form and function. More recently, science has established that cells are exquisitely sensitive to forces of varying magnitudes and time scales, and they convert mechanical stimuli into a chemical response. This phenomenon, termed mechanotransduction, is an integral part of cellular physiology and has a profound impact on the development of the organism. Furthermore, malfunctioning mechanical properties or mechanotransduction often leads to pathology of the organism. In this review, we describe mechanotransduction and the theories underlying how forces may be sensed, from the molecular to organism scale. The influence of mechanotransduction on normal and abnormal development, such as stem cell differentiation and cancer, is also reviewed. Studies illustrate the diversity of mechanotransduction, and the major role it has on organism homeostasis. Cells employ a variety of mechanisms, which differ depending upon cell type and environment, to sense and respond to forces.
Kolahi
Kevin S
KS
Molecular Cell Biomechanics Laboratory, Department of Bioengineering, University of California, Berkeley, CA 94720-1762, USA.
Mofrad
Mohammad R K
MR
D000818:Animals; D002468:Cell Physiological Phenomena; D004848:Epithelium / Q000254:growth & development / Q000502:physiology; D022001:Focal Adhesions / Q000502:physiology; D006706:Homeostasis; D007473:Ion Channels / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D013314:Stress, Mechanical
D007473:Ion Channels