title: Massive transfusion and blood product use in the pediatric trauma patient.
abstract: Hemorrhagic shock in the pediatric trauma patient is an uncommon but fundamental problem for the treating clinician. Current management of hemorrhagic shock involves initial resuscitation with crystalloid fluids followed by infusion of blood components as necessary. In management of the adult trauma patient, many institutions have implemented massive transfusion protocols to guide transfusion in situations requiring or anticipating the use of greater than 10 U of packed red blood cells. In the pediatric population, guidelines for massive transfusion are vague or nonexistent. Adult trauma transfusion protocols can be applied to children until a pediatric protocol is validated. Here, we attempt to identify certain principles of transfusion therapy specific to pediatric trauma and outline a sample pediatric massive transfusion protocol that may be used to guide resuscitation. Also, adjuncts to transfusion, such as colloid fluids, other plasma expanders or hemoglobin substitutes, and recombinant activated factor VII, are discussed.
authors.affiliation: Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Dehmer
authors.forename: William T
authors.initials: WT
authors.lastname: Adamson
mesh_terms: D016913:Blood Component Transfusion; D001802:Blood Substitutes / Q000008:administration & dosage; D001810:Blood Volume; D002648:Child; D002985:Clinical Protocols; D015942:Factor VIIa / Q000008:administration & dosage; D006454:Hemoglobins / Q000008:administration & dosage; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage; D012771:Shock, Hemorrhagic / Q000209:etiology / Q000628:therapy*; D014947:Wounds and Injuries / Q000150:complications / Q000628:therapy*
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C509893:PolyHeme; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa