title: Second high-dose chemotherapy intensification followed by hematopoietic stem cell transplantation applying a novel high-dose topotecan-based regimen in an adult Wilms' tumor patient: case report.
abstract: High-dose chemotherapy and hematopoietic stem cell support remains a valuable treatment option for the rare patient population with relapsed Wilms' tumor. Here we report the case of a 22-year-old male patient treated with two cycles of high-dose chemotherapy at relapse after nephrectomy and adjuvant chemotherapy; the first cycle with melphalan--etoposide--carboplatin and the second with a novel preparative regimen incorporating high-dose topotecan (topotecan--cyclophosphamide--melphalan). A detailed discussion and literature review pertaining to that case is provided.
authors.affiliation: Department of Medicine, Second Division of Medical Oncology, Metaxa Cancer Hospital, 51 Botassi Street, Piraeus, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Daladimos
authors.forename: Evangelos
authors.initials: E
authors.lastname: Theotikos
authors.forename: Aggelos
authors.initials: A
authors.lastname: Athanasopoulos
authors.forename: George
authors.initials: G
authors.lastname: Tsakonas
authors.forename: Athanasios
authors.initials: A
authors.lastname: Karabelis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Mylonakis
authors.forename: Christos
authors.initials: C
authors.lastname: Kosmas
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009392:Nephrectomy; D019772:Topotecan / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy* / Q000601:surgery*; D055815:Young Adult
chemical_list: D005047:Etoposide; D019772:Topotecan; D003520:Cyclophosphamide; D016190:Carboplatin; D008558:Melphalan