Expansion of human cord blood hematopoietic stem cells for transplantation.
A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture (Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically.
Chou
Song
S
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Chu
Pat
P
Hwang
William
W
Lodish
Harvey
H
D018929:Cell Culture Techniques / Q000379:methods; D049109:Cell Proliferation; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D011687:Purines / Q000378:metabolism
D011687:Purines