title: A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression.
abstract: BACKGROUND
  Obesity is associated with clinical depression among women. However, depressed women are often excluded from weight loss trials.
  
  
  OBJECTIVE
  This study examined treatment outcomes among women with comorbid obesity and depression.
  
  
  METHODS
  Two hundred three (203) women were randomized to behavioral weight loss (n = 102) or behavioral weight loss combined with cognitive-behavioral depression management (n = 101).
  
  
  RESULTS
  Average participant age was 52 years; mean baseline body mass index was 39 kg/m(2). Mean Patient Health Questionnaire and Hopkins Symptom Checklist (SCL-20) scores indicated moderate to severe baseline depression. Weight loss and SCL-20 changes did not differ between groups at 6 or 12 months in intent-to-treat analyses (p = 0.26 and 0.55 for weight, p = 0.70 and 0.25 for depressive symptoms).
  
  
  CONCLUSIONS
  Depressed obese women lost weight and demonstrated improved mood in both treatment programs. Future weight loss trials are encouraged to enroll depressed women.
authors.affiliation: University of Minnesota, Minneapolis, USA. linde074@umn.edu
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Linde
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Simon
authors.forename: Evette J
authors.initials: EJ
authors.lastname: Ludman
authors.forename: Laura E
authors.initials: LE
authors.lastname: Ichikawa
authors.forename: Belinda H
authors.initials: BH
authors.lastname: Operskalski
authors.forename: David
authors.initials: D
authors.lastname: Arterburn
authors.forename: Paul
authors.initials: P
authors.lastname: Rohde
authors.forename: Emily A
authors.initials: EA
authors.lastname: Finch
authors.forename: Robert W
authors.initials: RW
authors.lastname: Jeffery
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D015992:Body Mass Index; D015897:Comorbidity; D003863:Depression / Q000523:psychology; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D005260:Female; D006801:Humans; D007061:Idaho / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D016896:Treatment Outcome; D014861:Washington / Q000453:epidemiology; D015431:Weight Loss