title: Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.
abstract: Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices.
authors.affiliation: Department of Chemistry, New York University, New York, NY 10003, USA.
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Guarracino
authors.forename: Brooke N
authors.initials: BN
authors.lastname: Bullock
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Arora
mesh_terms: D032701:Biomimetics; D001704:Biopolymers / Q000737:chemistry*; D015195:Drug Design; D008024:Ligands; D017433:Protein Structure, Secondary; D011506:Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D001704:Biopolymers; D008024:Ligands; D011506:Proteins