Selenium or selenium plus folic acid intake improves the detrimental effects of ethanol on pups' selenium balance.
The levels of folic acid and selenium, two nutrients with antioxidant properties, decrease in dams exposed to ethanol during gestation and lactation. This decrease affects their antioxidant balance, and consequently the health of their offspring. In this study we have proved that a supplemented diet with Se (0.5 ppm) or with Se (0.5 ppm) plus folic acid (8 ppm) to ethanol-exposed (20%v/v) dams prevents the ethanol-provoked effects in their offspring's Se deposits. Se levels in milk, serum, urine, faeces and several tissues were measured by graphite-furnace atomic absorption spectrometry. Results show that ethanol decreases Se deposits in pups' heart, liver, kidney and testes. However Se levels in pancreas and in serum were increased by ethanol; it also compromised the weight and the length of the offspring at the end of lactation. Our supplemented diets to ethanol dams increased all of these impaired levels, and restored Se pancreas concentration to a control status. However Se-only therapy mainly displaces Se to serum, kidney and spleen, and co-treatment with Se plus folic acid, mainly displaces Se to liver and brain. This data demonstrate that the qualitative and quantitative Se organ deposits depend on ethanol consumption, Se status, and the presence of other antioxidants.
Ojeda
M L
ML
Department of Physiology and Zoology, Faculty of Pharmacy, Seville University, Seville, Spain.
Jotty
K
K
Nogales
F
F
Murillo
M L
ML
Carreras
O
O
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D004032:Diet; D019587:Dietary Supplements; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005260:Female; D005492:Folic Acid / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects; D006706:Homeostasis / Q000502:physiology; D007774:Lactation / Q000502:physiology; D008297:Male; D008892:Milk / Q000737:chemistry; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000032:analysis / Q000378:metabolism*; D018036:Selenium Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution
D000975:Antioxidants; D002492:Central Nervous System Depressants; D018036:Selenium Compounds; D000431:Ethanol; D005492:Folic Acid; D012643:Selenium