A clinical, radiographic and laboratory evaluation of prognostic factors in 363 patients with malignant pleural mesothelioma.
BACKGROUND
Malignant pleural mesothelioma (MPM) has a poor prognosis.


OBJECTIVE
Only few studies in literature investigated the presence of pleural fluid and radiographic findings for the prognosis of MPM.


METHODS
We retrospectively investigated the hospital charts of 363 MPM patients who were diagnosed from January 1989 to March 2010. Survival time was calculated by the Kaplan-Meier method. Pretreatment clinical, laboratory and radiographic features of each patient at the time of diagnosis were obtained from patients' charts.


RESULTS
The mean age of 363 patients (217 men, 146 women) was 50.6 ± 11.2 years (range 19-85) and the mean survival time was 11.7 ± 8.6 months (range 1-53). Histological types of MPM were epithelial (71.2%), mixed (15.9%) and sarcomatous type (4.9%). The frequency of disease stages were 31.4% for stage 1, 24.2% for stage 2, 28.6% for stage 3 and 15.8% for stage 4. The most frequent symptoms were dyspnea (82.1%), chest pain (68.3%) and weight loss (58.9%). Results of univariate and multivariate analyses revealed that a Karnofsky performance score ≤60, a pleural fluid glucose level ≤40 mg/dl, a C-reactive protein level >50 mg/l, a serum lactate dehydrogenase level >500 U/l, the presence of pleural fluid, pleural thickening >1 cm and a platelet count of >420 × 10(3)/μl were found to be associated with poor prognosis in MPM.


CONCLUSIONS
Our data suggest that low pleural fluid glucose and high C-reactive protein, the presence of pleural fluid and pleural thickening were associated with poor MPM prognosis. Further prospective studies are needed to highlight prognostic factors more clearly.
Tanrikulu
Abdullah Cetin
AC
Department of Chest Disease, Dicle University, Diyarbakir, Turkey.
Abakay
Abdurrahman
A
Kaplan
Mehmet Ali
MA
Küçüköner
Mehmet
M
Palanci
Yilmaz
Y
Evliyaoglu
Osman
O
Sezgi
Cengizhan
C
Sen
Hadice
H
Carkanat
Ali İhsan
Aİ
Kirbas
Gokhan
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000401:mortality*; D008875:Middle Aged; D015999:Multivariate Analysis; D016066:Pleural Effusion, Malignant / Q000175:diagnosis* / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult