title: [Cytokines in bone diseases. Involvement of cytokines in bone metastasis].
abstract: Bone metastases are critically involved in both QOL and ADL in patients with malignant diseases. This issue is seriously important for many patients with cancer expecting rather good prognosis. Recent studies indicate that there are several factors either specific to cancer cells or to bone tissue that participate in establishing bone metastasis. Most of those factors are members of cytokine family. Development of therapeutic tools against bone metastasis is now focusing on blocking actions of cytokines that are involved in establishment of bone metastasis.
authors.affiliation: Toranomon Hospital Endocrine Center.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeuchi
mesh_terms: D000203:Activities of Daily Living; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D016207:Cytokines / Q000502:physiology*; D055808:Drug Discovery; D005260:Female; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D011471:Prostatic Neoplasms / Q000473:pathology; D011788:Quality of Life; D013964:Thyroid Neoplasms / Q000473:pathology
chemical_list: D016207:Cytokines