title: Granulomatous lymphadenitis associated with Actinobacillus pleuropneumoniae serotype 2 in slaughter barrows.
abstract: This study evaluated the occurrence of granulomatous lymphadenitis and its association with Actinobacillus spp. in 151 653 slaughtered pigs. Markedly enlarged pulmonary hilar, mediastinal, mandibular or hepatic lymph nodes were detected in 6 castrated males. The cut surfaces showed multifocal yellow-white lesions. Histologically, gram-negative bacilli were visible in the centers of the lesions with asteroid bodies, epithelioid cells, and multinucleated giant cells. Dense fibrous connective tissue surrounded these granulomatous lesions. Immunohistochemically, the organisms reacted with polyclonal antibodies against Actinobacillus pleuropneumoniae serotype 2 in all 6 barrows. The organism was isolated from the lymph nodes of all 6 animals. The results indicate that the granulomatous lymphadenitis was associated with A. pleuropneumoniae serotype 2 and the disorder had a tendency to occur in slaughter barrows.
authors.affiliation: Toyama Prefectural Meat Inspection Center, 28-4 Shinbori, Imizu 934-0035, Japan.
authors.forename: Takemi
authors.initials: T
authors.lastname: Ohba
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibahara
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Ariko
authors.initials: A
authors.lastname: Takashima
authors.forename: Masataka
authors.initials: M
authors.lastname: Nagoshi
authors.forename: Masanori
authors.initials: M
authors.lastname: Kubo
mesh_terms: D000189:Actinobacillus Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000145:classification / Q000276:immunology / Q000302:isolation & purification; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008199:Lymphadenitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012703:Serotyping / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology* / Q000473:pathology*
chemical_list: D000907:Antibodies, Bacterial