Progress and prospects: stem cells and neurological diseases.
The central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such as Parkinson's disease (PD), Alzheimer's disease or Huntington's disease (HD), or in acute injuries resulting in rapid cell loss for example, in cerebrovascular damage (for example, stroke) or spinal cord injury. Although the adult brain contains small numbers of stem cells in restricted areas, they do not contribute significantly to functional recovery. Transplantation of stem cells or stem cell-derived progenitors has long been seen as a therapeutic solution to repair the damaged brain. With the advent of the induced pluripotent stem cells technique a new and potentially better source for transplantable cells may be available in future. This review aims to highlight current strategies to replace lost cellular populations in neurodegenerative diseases with the focus on HD and PD and traumatic brain injuries such as stroke, discussing many of the technical and biological issues associated with central nervous system cell transplantation.
Gögel
S
S
Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College London, London, UK. stefanie.gogel@kcl.ac.uk
Gubernator
M
M
Minger
S L
SL
D000818:Animals; D001930:Brain Injuries / Q000628:therapy; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000378:metabolism / Q000628:therapy*; D020127:Recovery of Function; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism