title: Effect of input waveform pattern and large blood vessel existence on destruction of liver tumor using radiofrequency ablation: finite element analysis.
abstract: Much research has been directed at improving the effectiveness of the radiofrequency (RF) ablation of hepatocellular carcinomas. In that point of view, this study was performed to provide comprehensive information of the relation between RF waveforms and thermodynamic response of the tissue with the consideration of four different types of RF waveforms (half-sine, half-square, half-exponential, and damped-sine) to maximize the amount of tumor tissue removed while maintaining the advantages of RF ablation. For the aim of this study, finite element models incorporating results from previous numerical models were used and validated with ex vivo experiments. From analyses of the entire results, we concluded that this study may prove valuable as a first step in providing comprehensive information of the relation between various RF waveforms and thermodynamic responses within the tissue during the RF ablation process. This study may also contribute toward studies to determine an optimum RF waveform capable of maximizing the amount of tumor tissue removed while maintaining the advantages of RF ablation.
authors.affiliation: Gerontechnology Center, Korea Institute of Industrial Technology, Cheonan, Chungnam 330-825, Korea.
authors.forename: Dohyung
authors.initials: D
authors.lastname: Lim
authors.forename: Bumseok
authors.initials: B
authors.lastname: Namgung
authors.forename: Dae Gon
authors.initials: DG
authors.lastname: Woo
authors.forename: Jin Seung
authors.initials: JS
authors.lastname: Choi
authors.forename: Han Sung
authors.initials: HS
authors.lastname: Kim
authors.forename: Gye Rae
authors.initials: GR
authors.lastname: Tack
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D002417:Cattle; D020342:Finite Element Analysis; D006801:Humans; D006979:Hyperthermia, Induced / Q000706:statistics & numerical data; D066298:In Vitro Techniques; D008099:Liver / Q000098:blood supply / Q000601:surgery; D008113:Liver Neoplasms / Q000098:blood supply* / Q000503:physiopathology / Q000628:therapy*; D008954:Models, Biological; D000078702:Radiofrequency Therapy; D013816:Thermodynamics