A novel taxane 13-glucoside and other taxanes from the leaves of Taxus cuspidata.
Three new taxanes, 2 α,9 α,10 β-triacetoxy-13 α-( β-D-glucopyranosyloxy)taxa-4(20),11-dien-5 α-ol, 5 α,10 β,13 α-triacetoxytax-11-ene-2 α,7 β,9 α,20-tetraol, and 5 α,10 β,13 β-triacetoxy-2 α,7 β-dihydroxy-2(3→20) abeotaxa-4(20),11-dien-9-one, were isolated from the leaves of the Japanese yew, Taxus cuspidata. Compound 1 is the first example of a taxane with 13-glycosidic linkage.
Ni
Zhi-Yu
ZY
Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Hebei, P. R. China.
Dong
Mei
M
Cong
Bin
B
Sauriol
Françoise
F
Zhang
Man-Li
ML
Wang
Yu-Fang
YF
Huo
Chang-Hong
CH
Shi
Qing-Wen
QW
Kiyota
Hiromasa
H
D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification*; D020946:Taxus / Q000737:chemistry*
C561248:2alpha,9alpha,10beta-triacetoxy-13alpha(beta-D-glucopyranosyloxy)taxa-4(20),11-dien-5alpha-ol; C561246:5alpha,10beta,13alpha-triacetoxytax-11-ene-2alpha,7beta,9alpha,20-tetraol; C561247:5alpha,10beta,13beta-triacetoxy-2 alpha,7beta-dihydroxy-2(3-20) abeotaxa-4(20),11-dien-9-one; D005960:Glucosides; D010936:Plant Extracts; D043823:Taxoids