title: A comparison of the immune responses of dogs exposed to canine distemper virus (CDV) - Differences between vaccinated and wild-type virus exposed dogs.
abstract: Canine distemper virus (CDV)-specific immune response was measured in different dog populations. Three groups of vaccinated or wild-type virus exposed dogs were tested: dogs with a known vaccination history, dogs without a known vaccination history (shelter dogs), and dogs with potential exposure to wild-type CDV. The use of a T-cell proliferation assay demonstrated a detectable CDV-specific T-cell response from both spleen and blood lymphocytes of dogs. Qualitatively, antibody assays [enzyme-linked immunosorbent assay (ELISA) and neutralization assay] predicted the presence of a T-cell response well, although quantitatively neither antibody assays nor the T-cell assay correlated well with each other. An interesting finding from our study was that half of the dogs in shelters were not vaccinated (potentially posing a public veterinary health problem) and that antibody levels in dogs living in an environment with endemic CDV were lower than in vaccinated animals.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Perrone
authors.forename: Scott
authors.initials: S
authors.lastname: Bender
authors.forename: Stefan
authors.initials: S
authors.lastname: Niewiesk
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004216:Distemper / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004285:Dogs; D005260:Female; D008297:Male; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines