title: Unexpectedly stable artificial duplex from flexible acyclic threoninol.
abstract: A new foldamer, acyclic threoninol nucleic acid (aTNA), has been synthesized by tethering each of the genetic nucleobases A, G, C, and T to d-threoninol molecules, which were then incorporated as building blocks into a scaffold bearing phosphodiester linkages. We found that with its fully complementary strand in an antiparallel fashion, the aTNA oligomer forms an exceptionally stable duplex that is far more stable than corresponding DNA or RNA duplexes, even though single-stranded aTNA is rather flexible and thus does not take a preorganized structure.
authors.affiliation: Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. asanuma@mol.nagoya-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Asanuma
authors.forename: Takasuke
authors.initials: T
authors.lastname: Toda
authors.forename: Keiji
authors.initials: K
authors.lastname: Murayama
authors.forename: Xingguo
authors.initials: X
authors.lastname: Liang
authors.forename: Hiromu
authors.initials: H
authors.lastname: Kashida
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D002072:Butylene Glycols / Q000737:chemistry*; D002942:Circular Dichroism; D008958:Models, Molecular
chemical_list: D000605:Amino Alcohols; D002072:Butylene Glycols; C532652:threoninol