title: Clinical features of 215 stage I ovarian tumors in Japanese women.
abstract: OBJECTIVE
  Differences of the clinical features of Stage I borderline ovarian tumors and Stage I ovarian cancer need to be clarified.
  
  
  METHODS
  We retrospectively investigated 215 patients with Stage I ovarian tumors (67 with borderline tumors and 148 with ovarian cancer) treated between 1988 and 2001.
  
  
  RESULTS
  Only one patient with a borderline tumor developed recurrence, while recurrence was found in 20 patients with Stage I ovarian cancer. There was a significant difference in the recurrence rate between patients with Stage Ia or Ib ovarian cancer and those with Stage Ic cancer (p = 0.007). Clear cell adenocarcinoma showed a higher recurrence rate. Among our patients with recurrence, only five in whom the recurrent tumor could be surgically resected are currently alive and disease-free.
  
  
  CONCLUSIONS
  This study confirmed the low aggressiveness of Stage I borderline ovarian tumors and high aggressiveness of Stage Ic ovarian cancer or clear cell adenocarcinoma. In patients with recurrence, surgical resection may improve survival.
authors.affiliation: Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan. kaku@belle.shiga-med.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Kaku
authors.forename: N
authors.initials: N
authors.lastname: Takeshima
authors.forename: K
authors.initials: K
authors.lastname: Umayahara
authors.forename: R
authors.initials: R
authors.lastname: Furuta
authors.forename: F
authors.initials: F
authors.lastname: Akiyama
authors.forename: K
authors.initials: K
authors.lastname: Takizawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy