title: Usefulness of magnifying endoscopy for iodine-unstained lesions in a high-risk esophageal cancer population.
abstract: OBJECTIVE
  To investigate the usefulness of magnified observations of iodine-unstained esophageal lesions in the histological diagnosis of esophageal mucosa abnormalities, in high-risk esophageal cancer groups.
  
  
  METHODS
  The subjects included 38 patients who had at least one of the four criteria known to be high-risk factors for esophageal cancer. Following endoscopic observation, magnified observations were performed on iodine-unstained lesions of the esophagus. The total number of lesions was 43. These lesions were classified as type A (clear papilla), type B (fused papilla), and type C (non-visible papilla) according to the findings. Tissue biopsy was then carried out. Finally the histological findings were graded in terms of histological factors, and their relationships were compared.
  
  
  RESULTS
  Of the 43 lesions, 11 were type A, 17 were type B, and 15 were type C under magnifying endoscopy. Histological findings such as inflammatory cell infiltration and basal cell hyperplasia were significantly increased in type B and type C lesions compared with type A lesions (P < 0.05). Low-grade esophageal dysplasia was apparent in 1 (9%) of 11 type A lesions, in 3 (18%) of 17 type B lesions, and in 6 (40%) of 15 type C lesions, with the highest rate in type C.
  
  
  CONCLUSIONS
  Magnified observations of the esophagus, classified by papillary aspects using magnifying endoscopy of iodine-unstained lesions in high-risk esophageal cancer groups, are considered useful in estimating dysplasia and inflammation of esophageal mucosa.
authors.affiliation: Institute for Digestive Research, SoonChunHyang University College of Medicine, Seoul 140-743, South Korea.
authors.forename: Ik Seong
authors.initials: IS
authors.lastname: Choi
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Jang
authors.forename: Won Young
authors.initials: WY
authors.lastname: Cho
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Lee
authors.forename: Hyun Gun
authors.initials: HG
authors.lastname: Kim
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Lee
authors.forename: Soung Won
authors.initials: SW
authors.lastname: Jeong
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Cho
authors.forename: Joon Seong
authors.initials: JS
authors.lastname: Lee
authors.forename: So Young
authors.initials: SY
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D004945:Esophagoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007455:Iodine; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology*; D012307:Risk Factors
chemical_list: D007455:Iodine