title: Bioactive glass scaffold with similar structure and mechanical properties of cancellous bone.
abstract: Natural bone is an amazing material because of its structure and mechanics. It is a challenge to find a bone substituted material mimicking natural bone intended to suffice for the need for bone repair and regeneration. In this study, a biomorphic material with similar structure and mechanical properties of cancellous bone has been fabricated by using demineralized cancellous bone as a template. Well-oriented particles in the pore walls could be observed clearly. The compressive strength of this scaffold was up to about 4.9 ± 0.2 MPa, close to the lower limit of the natural bone and 30 times of bioactive glass scaffolds, even though the porosity was up to 90%. This kind of bioactive glass composite scaffolds presented high resistance to deformation and showed an excellent shape restoration property. It is very close to a natural cancellous bone with a similar macro- and micro-structure and force-extension behavior. These results suggested this material would have a good potential in bone tissue engineering.
authors.affiliation: Division of Applied Materials Science, Department of Engineering Science, Uppsala University, Sweden.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
mesh_terms: D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001842:Bone and Bones; D005898:Glass; D008855:Microscopy, Electron, Scanning
chemical_list: D001672:Biocompatible Materials