A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma.
Central neurocytomas are low-grade tumors of neuronal origin located in the lateral ventricle that present predominantly with raised intracranial pressure. In this retrospective study, we investigated the clinical, radiological, histopathological and immunohistochemical features of eight patients (seven males and one female; age range 16-61 years; mean=35.1 years) with neurocytoma. Raised intracranial pressure was the most common presenting feature. In addition, one patient presented with marked visual deterioration and one presented with a visual field defect. All lesions were located in the lateral ventricle (right lateral ventricle: four patients, left lateral ventricle: three patients, both ventricles: one patients). Radiology showed marked intratumoral calcification in two patients. Total microsurgical excision was achieved in seven patients. Histopathology showed sheets of monotonously small-to-medium-sized neoplastic cells with uniform round-to-oval nuclei and inconspicuous nucleoli. Immunohistochemistry was positive for synaptophysin and neuron-specific enolase (NSE) in all tumors, and glial fibrillary acidic protein was focally positive in two patients. One patient had lipomatous differentiation within the tumor. No recurrence was noted in any of our patients until the last follow-up; however, there were two deaths in our series.
Jaiswal
Sushila
S
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India. sushilapath@yahoo.com
Vij
Mukul
M
Rajput
Dinesh
D
Mehrotra
Anant
A
Jaiswal
Awadhesh Kumar
AK
Srivastava
Arun Kumar
AK
Behari
Sanjay
S
Krishnani
Narendra
N
D000293:Adolescent; D000328:Adult; D002114:Calcinosis / Q000209:etiology; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019586:Intracranial Hypertension / Q000209:etiology; D020547:Lateral Ventricles / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018306:Neurocytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000096:biosynthesis; D016708:Synaptophysin / Q000096:biosynthesis; D055815:Young Adult
D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase