Cell physician: reading cell motion: a mathematical diagnostic technique through analysis of single cell motion.
Cell motility is an essential phenomenon in almost all living organisms. It is natural to think that behavioral or shape changes of a cell bear information about the underlying mechanisms that generate these changes. Reading cell motion, namely, understanding the underlying biophysical and mechanochemical processes, is of paramount importance. The mathematical model developed in this paper determines some physical features and material properties of the cells locally through analysis of live cell image sequences and uses this information to make further inferences about the molecular structures, dynamics, and processes within the cells, such as the actin network, microdomains, chemotaxis, adhesion, and retrograde flow. The generality of the principals used in formation of the model ensures its wide applicability to different phenomena at various levels. Based on the model outcomes, we hypothesize a novel biological model for collective biomechanical and molecular mechanism of cell motion.
Coskun
Hasan
H
Department of Mathematics, Ohio State University, Columbus, OH, USA. hcoskun@math.ohio-state.edu
Coskun
Huseyin
H
D002465:Cell Movement / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology*; D008954:Models, Biological; D014741:Video Recording