DAnCER: disease-annotated chromatin epigenetics resource.
Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically interacting proteins, and their disruption has been linked to a number of complex human diseases. CM remains largely unexplored, however, especially in higher eukaryotes such as human. Here we present the DAnCER resource, which integrates information on genes with CM function from five model organisms, including human. Currently integrated are gene functional annotations, Pfam domain architecture, protein interaction networks and associated human diseases. Additional supporting evidence includes orthology relationships across organisms, membership in protein complexes, and information on protein 3D structure. These data are available for 962 experimentally confirmed and manually curated CM genes and for over 5000 genes with predicted CM function on the basis of orthology and domain composition. DAnCER allows visual explorations of the integrated data and flexible query capabilities using a variety of data filters. In particular, disease information and functional annotations are mapped onto the protein interaction networks, enabling the user to formulate new hypotheses on the function and disease associations of a given gene based on those of its interaction partners. DAnCER is freely available at http://wodaklab.org/dancer/.
Turinsky
Andrei L
AL
Hospital for Sick Children, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada.
Turner
Brian
B
Borja
Rosanne C
RC
Gleeson
James A
JA
Heath
Michael
M
Pu
Shuye
S
Switzer
Thomas
T
Dong
Dong
D
Gong
Yunchen
Y
On
Tuan
T
Xiong
Xuejian
X
Emili
Andrew
A
Greenblatt
Jack
J
Parkinson
John
J
Zhang
Zhaolei
Z
Wodak
Shoshana J
SJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002843:Chromatin / Q000378:metabolism*; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D057890:Epigenomics; D006801:Humans; D051379:Mice; D058977:Molecular Sequence Annotation; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics
D002843:Chromatin