LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.
Membrane rafts are microdomains involved in a number of biologically important processes, including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins, containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays important roles in signal initiation by several other immunologically important receptors. Here we review recent progress in the elucidation of several aspects of this protein, e.g. the controversy concerning the importance of LAT being present in membrane rafts, the involvement in signalling through a number of receptors other than the T cell receptor and the puzzling phenotype of some LAT mutants.
Horejsí
Václav
V
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic. horejsi@biomed.cas.cz
Otáhal
Pavel
P
Brdicka
Tomás
T
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; C110810:LAT protein, human; D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface