title: The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells.
abstract: The densely ciliated granule cell layer of the adult murine hippocampal dentate gyrus is one of two sites of adult neurogenesis. The granule cells have already been proven to localize their SSTR3 (somatostatin receptor 3) receptors to their so-called primary cilia. Here we show for the first time that 70-90% of these cells in 7-18 months-old wild-type and 3×Tg-AD (Alzheimer disease transgenic) mice also load p75(NTR) receptors into the structures containing SSTR3, i.e., their primary cilia. On the other hand, p75(NTR')s TrkA co-receptors were not localized to cilia but conventionally distributed throughout the cell surface. Significantly fewer cells (20-40%) in the hippocampal CA1 and CA3 regions and cerebral cortex have p75(NTR) containing cilia. While we don't know what the impact of the cilial localization of p75(NTR) on dentate gyral adult neurogenesis and memory encoding might be, the cilia's amyloid β-activatable p75(NTR) receptors could be damaging or lethal to the hippocampal functioning of amyloid β-accumulating Alzheimer brain.
authors.affiliation: Molecular Signalling Group, National Research Council Canada, Institute for Biological Sciences, Ottawa, Ontario, Canada. Balu.Chakravarthy@nrc-cnrc.gc.ca
authors.forename: Balu
authors.initials: B
authors.lastname: Chakravarthy
authors.forename: Chantal
authors.initials: C
authors.lastname: Gaudet
authors.forename: Michel
authors.initials: M
authors.lastname: Ménard
authors.forename: Trevor
authors.initials: T
authors.lastname: Atkinson
authors.forename: Anna
authors.initials: A
authors.lastname: Chiarini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Dal Prà
authors.forename: James
authors.initials: J
authors.lastname: Whitfield
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000378:metabolism; D056654:CA3 Region, Hippocampal / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D020800:Receptor, Nerve Growth Factor