title: Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola.
abstract: Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
authors.forename: Quan-Xiang
authors.initials: QX
authors.lastname: Wu
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Crews
authors.forename: Marija
authors.initials: M
authors.lastname: Draskovic
authors.forename: Johann
authors.initials: J
authors.lastname: Sohn
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Johnson
authors.forename: Karen
authors.initials: K
authors.lastname: Tenney
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Valeriote
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yao
authors.forename: Leonard F
authors.initials: LF
authors.lastname: Bjeldanes
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004151:Dipeptides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D004151:Dipeptides; C555149:azonazine