title: [Microbiota and enteral nutrition].
abstract: Enteral nutrition is a nutritional therapy that is used in up to 10% of hospitalized patients. It involves a dramatic change in the provision of nutrients to the intestine and this, along with metabolic stress and drugs used, is responsible for a marked dysbiosis. Even though there is a huge level of between-subject variability, this dysbiosis is characterized by a decrease in the dominant flora, an increase in potentially pathogenic microorganisms and a reduction in the number of individual strains. The main characteristic of these changes in the microbiota is diarrhea, which has many consequences in these patients. Saccharomyces boulardii is able to prevent enteral nutrition-associated diarrhea, probably through an increase in short-chain fatty acid production. Alongside its role in the onset and prevention of diarrhea, the microbiota may be involved in energy harvesting and changes in the nutritional status. Manipulations of the microbiota may therefore be a novel way to increase feeding efficiency in tube-fed patients.
authors.affiliation: Division of Digestive Diseases, University Hospital of Nice, France. stephane.schneider@unice.fr
authors.forename: S-M
authors.initials: SM
authors.lastname: Schneider
mesh_terms: D003967:Diarrhea / Q000209:etiology / Q000517:prevention & control*; D004750:Enteral Nutrition / Q000009:adverse effects*; D006801:Humans; D054892:Metagenome; D019936:Probiotics / Q000627:therapeutic use*; D012440:Saccharomyces / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome