Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20.
Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.5-11.0 exhibit a single well defined reduction peak which may be due to the reduction of -CC- group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.8-7.2μgmL(-1). The calculated LOD and LOQ are 1.8 and 6.0ngmL(-1) by SWCAdSV and 8.1 and 27.2ngmL(-1) by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique.
Jain
Rajeev
R
School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India. rajeevjain54@yahoo.co.in
Vikas
Rather
Jahangir Ahmad
JA
D000327:Adsorption; D002244:Carbon / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D010208:Papaverine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011136:Polysorbates / Q000737:chemistry / Q000494:pharmacology*; D015203:Reproducibility of Results; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D013607:Tablets
D011136:Polysorbates; D013501:Surface-Active Agents; D013607:Tablets; D002244:Carbon; C005317:drotaverin; D010208:Papaverine