title: Organising pneumonia associated with fumaric acid ester treatment for psoriasis.
abstract: BACKGROUND
  We present the case of a 49-year old male who presented with dyspnoea, cough, weight loss, night sweats and general malaise. He had been on treatment with oral fumaric acid esters (FAE, Fumaderm®; Biogen Idec GmbH, Ismaning, Germany) for 6 months.
  
  
  METHODS
  Report of a case.
  
  
  RESULTS
  His chest X-ray showed patchy infiltrates in the left upper lobe which failed to resolve under empiric antibiotic therapy. A computed tomography of thorax revealed bilateral, mostly peripheral foci of consolidation with air bronchograms. Transbronchial biopsies showed a pattern of organising pneumonia (OP).
  
  
  CONCLUSIONS
  Therapy with oral prednisolone (40 mg/day) resulted in a rapid clinical and radiological improvement. An association of FAE and OP has not previously been reported. Please cite this paper as: Deegan AP, Kirby B, Rogers S, Crotty TB and McDonnell TJ. Organising pneumonia associated with fumaric acid ester treatment for psoriasis.
authors.affiliation: St. Vincent's University Hospital, Respiratory Department, Dublin, Ireland.
authors.forename: Alexander Paul
authors.initials: AP
authors.lastname: Deegan
authors.forename: Brian
authors.initials: B
authors.lastname: Kirby
authors.forename: Sarah
authors.initials: S
authors.lastname: Rogers
authors.forename: Tom Bernard
authors.initials: TB
authors.lastname: Crotty
authors.forename: Timonthy John
authors.initials: TJ
authors.lastname: McDonnell
mesh_terms: D000284:Administration, Oral; D001706:Biopsy; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005650:Fumarates / Q000008:administration & dosage / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D005650:Fumarates; D005938:Glucocorticoids; D011239:Prednisolone