title: Design and synthesis of biomimetic multicomponent all-bone-minerals bionanocomposites.
abstract: We report a simple and novel top-down method based on a drop-casting process for the controlled synthesis of all-bone-minerals biomimetic multicomponent bionanocomposites. Integration of micro- and nanoscale binary features into nanofibrous biocompatible polymer scaffold structures is successfully demonstrated. Compositional control of the constituents of the bionanocomposites resulted in uniform dispersion of hydroxyapatite nanospheres (~100-500 nm) among collagen nanofibers (~100 nm). The composites also present high calcium and oxygen contents and adequate phosphorus compositions comparable to the levels of bone tissues. Our preliminary results open up further possibilities to develop advanced tissue-engineered bionanocomposites for bone grafting.
authors.affiliation: Center for Nanoscience and Technology (NDnano), Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, United States. abiswas@nd.edu
authors.forename: Abhijit
authors.initials: A
authors.lastname: Biswas
authors.forename: Ilker S
authors.initials: IS
authors.lastname: Bayer
authors.forename: He
authors.initials: H
authors.lastname: Zhao
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Fumiya
authors.initials: F
authors.lastname: Watanabe
authors.forename: Alexandru S
authors.initials: AS
authors.lastname: Biris
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D001842:Bone and Bones / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D008903:Minerals