title: The relevance of early TCD monitoring in the intensive care units for the confirming of brain death diagnosis.
abstract: Brain death (BD) diagnosis is the clinical assessment of the irreversible loss of function of the entire brain, including the brainstem. Transcranial Doppler (TCD) examination is used in several countries as a confirmatory test to assess cerebral circulatory arrest (CCA). A total of 1,400 TCD examinations were performed in 623 patients (pts) admitted to intensive care units (ICUs) of our hospital during the last 6 years. Oscillating flow, systolic spikes and the absence of any TCD signal were considered as diagnostic patterns of irreversible CCA. TCD patterns of CCA were detected in 56 pts. In 25 pts, deeply sedated with barbiturate therapy, TCD was employed as confirmatory test for BD diagnosis and 14 of them could become organ and/or tissue donors. TCD is a safe and inexpensive tool that can be performed at the bedside, and it allows to shorten the diagnostic process of BD, which is the prerequisite for organ donation.
authors.affiliation: Department of Neurological and Psychiatrics Sciences, University of Florence, Viale Morgagni, 85, 50134, Florence, Italy. marinella.marinoni@unifi.it
authors.forename: Marinella
authors.initials: M
authors.lastname: Marinoni
authors.forename: Fabiana
authors.initials: F
authors.lastname: Alari
authors.forename: Veronica
authors.initials: V
authors.lastname: Mastronardi
authors.forename: Adriano
authors.initials: A
authors.lastname: Peris
authors.forename: Paola
authors.initials: P
authors.lastname: Innocenti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001926:Brain Death / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D055815:Young Adult