Krüppel-like transcription factors and control of pluripotency.
Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency. See research article http://www.biomedcentral.com/1741-7007/8/128.
Bourillot
Pierre-Yves
PY
Inserm U846, 18 avenue Doyen Lépine, 69500 Bron, France.
Savatier
Pierre
P
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D005786:Gene Expression Regulation / Q000235:genetics*; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*; D018085:Regulon / Q000235:genetics
D051741:Kruppel-Like Transcription Factors