Endocrine disruptors and Leydig cell function.
During the past decades, a large body of information concerning the effects of endocrine disrupting compounds (EDCs) on animals and humans has been accumulated. EDCs are of synthetic or natural origin and certain groups are known to disrupt the action of androgens and to impair the development of the male reproductive tract and external genitalia. The present overview describes the effects of the different classes of EDCs, such as pesticides, phthalates, dioxins, and phytoestrogens, including newly synthesized resveratrol analogs on steroidogenesis in Leydig cells. The potential impact of these compounds on androgen production by Leydig cells during fetal development and in the adult age is discussed. In addition, the possible role of EDCs in connection with the increasing frequency of abnormalities in reproductive development in animals and humans is discussed.
Svechnikov
K
K
Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Q2:08, E-17176 Stockholm, Sweden. konstantin.svechnikov@ki.se
Izzo
G
G
Landreh
L
L
Weisser
J
J
Söder
O
O
D000328:Adult; D000818:Animals; D052244:Endocrine Disruptors / Q000009:adverse effects; D004703:Endocrine System / Q000187:drug effects* / Q000196:embryology / Q000502:physiology; D004785:Environmental Pollutants / Q000633:toxicity; D006727:Hormone Antagonists / Q000494:pharmacology*; D006728:Hormones / Q000502:physiology; D006801:Humans; D007985:Leydig Cells / Q000502:physiology*; D008297:Male; D012098:Reproduction / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects
D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D006727:Hormone Antagonists; D006728:Hormones