Vascular protection and restorative therapy in ischemic stroke.
Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring cerebral blood flow in the acute phase of ischemic stroke but sometimes causing hemorrhagic transformation (HT); 2) stem cell therapy: the repair of disrupted neuronal networks with newly born neurons in the chronic phase of ischemic stroke. Firstly, we estimated the vascular protective effect of a free radical scavenger, edaravone, in the tPA-treated rat model of middle cerebral artery occlusion. Edaravone prevented dramatically decreased the hemorrhagic transformation and improved the neurologic score and survival rate of tPA-treated rats. Secondly, we attempted to restore brain tissue using a novel biomaterial, polydimethysiloxane-tetraethoxysilane (PDMS-TEOS) hybrid with or without vascular endothelial growth factor (VEGF), and we could show that implantation of a PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.
Yamashita
Toru
T
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Deguchi
Kentaro
K
Nagotani
Shoko
S
Abe
Koji
K
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology / Q000628:therapy*; D004129:Dimethylpolysiloxanes / Q000737:chemistry / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000502:physiology*; D058953:Neural Stem Cells / Q000166:cytology / Q000637:transplantation; D051381:Rats; D012821:Silanes / Q000737:chemistry / Q000627:therapeutic use; D020521:Stroke / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use
D004129:Dimethylpolysiloxanes; D012821:Silanes; D042461:Vascular Endothelial Growth Factor A; C040733:tetraethoxysilane; D010959:Tissue Plasminogen Activator