title: Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.
abstract: Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondria, dynamic organelles that function as the primary site of oxidative metabolism and play crucial roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis and intracellular signaling.
authors.affiliation: Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA. everdin@gladstone.ucsf.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hirschey
authors.forename: Lydia W S
authors.initials: LW
authors.lastname: Finley
authors.forename: Marcia C
authors.initials: MC
authors.lastname: Haigis
mesh_terms: D000818:Animals; D017209:Apoptosis; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D037761:Sirtuins