Olmesartan associated with acute renal failure in a patient with bilateral renal artery stenosis.
In patients with renal artery stenosis (RAS), the inhibition of renin-angiotensin-aldosterone system can cause deterioration of renal function. Here we present a 75-year-old man who developed acute renal failure after olmesartan treatment. Following discontinuation of olmesartan, his renal functions normalized. His renal Doppler ultrasonography and renal angiography showed findings consistent with bilateral RAS. In this case, unlike those previously reported, renal failure developed with olmesartan for the first time and after only a single dose, which is thought to be a new, safe, and tolerable antihypertensive agent. This is a well-defined effect of angiotensin-converting enzyme inhibitors, in patients with RAS. Also with the increasing use of angiotensin II receptor blockers (ARBs), renal failure associated with ARBs in patients with RAS is rising. The use of olmesartan also requires caution and close follow-up of renal functions for patients who have risk factors.
Bavbek
Nukhet
N
Department of Nephrology, Medical School, Fatih University, Ankara, Turkey.
Kasapoglu
Benan
B
Isik
Ayse
A
Kargili
Ayse
A
Kirbas
Ismail
I
Akcay
Ali
A
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D012078:Renal Artery Obstruction / Q000150:complications*; D013777:Tetrazoles / Q000009:adverse effects*
D047228:Angiotensin II Type 1 Receptor Blockers; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan