Gd-complexes of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs).
We report the synthesis of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H(2)O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R(1) relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.
Kim
Hee-Kyung
HK
Department of Medical & Biological Engineering, Kyungpook National University, Daegu, 702-701, Korea.
Park
Ji-Ae
JA
Kim
Kyeong Min
KM
Nasiruzzaman
Sk Md
SM
Kang
Duk-Sik
DS
Lee
Jongmin
J
Chang
Yongmin
Y
Kim
Tae-Jeong
TJ
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005296:Ferrous Compounds / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D000075163:Metallocenes; D004369:Pentetic Acid / Q000737:chemistry*; D051381:Rats; D012709:Serum Albumin / Q000737:chemistry; D013816:Thermodynamics
D003287:Contrast Media; D056831:Coordination Complexes; D005296:Ferrous Compounds; D047028:Macrocyclic Compounds; D000075163:Metallocenes; D012709:Serum Albumin; D004369:Pentetic Acid; D005682:Gadolinium; C004998:ferrocene