title: Clinicopathologic features and outcomes of metaplastic breast carcinoma: comparison with invasive ductal carcinoma of the breast.
abstract: OBJECTIVE
  Metaplastic breast carcinoma (MBC) is rare. Its clinicopathologic features and prognosis are uncertain. The aim of this study was to evaluate the clinicopathologic characteristics and outcomes in comparison with invasive ductal carcinoma (IDC).
  
  
  METHODS
  We reviewed the data of 29 patients with MBC and 4,851 patients with IDC, who received surgery at Yonsei University Severance Hospital between 1980 and 2008. Various clinicopathologic features, recurrence free, and overall survival were investigated and compared to each other.
  
  
  RESULTS
  Stage IV cases at diagnosis were more common in MBC (10.3%) than in IDC (0.9%). The incidence rates of triple negative breast cancer (TNBC) were significantly higher in MBC (84.0%) than in IDC (20.1%). Larger tumors (> 2 cm) and lower tendency of axillary metastasis were frequently observed in MBC. Only one of 24 preoperative core needle biopsies (CNB) correctly diagnosed MBC. There was no significant difference in survival between the two groups.
  
  
  CONCLUSIONS
  MBC was characterized by a higher incidence of TNBC, larger tumor size, and lower tendency of axillary metastasis, and was difficult to diagnose with CNB. Although the incidence of stage IV disease at diagnosis was higher in MBC, the survival rates of stage I-III were comparable to those of IDC.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Seho
authors.initials: S
authors.lastname: Park
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: So-Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Byeong-Woo
authors.initials: BW
authors.lastname: Park
authors.forename: Kyong-Sik
authors.initials: KS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D002277:Carcinoma / Q000175:diagnosis* / Q000503:physiopathology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015994:Incidence; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome