title: Development of a general palladium-catalyzed carbonylative Heck reaction of aryl halides.
abstract: The first general palladium-catalyzed carbonylative vinylation of aryl halides with olefins in the presence of CO has been developed. Applying a catalyst system consisting of [(cinnamyl)PdCl](2) and bulky imidazolyl-phosphine ligand L1 allows for the efficient and selective synthesis of α,β-unsaturated ketones under mild reaction conditions. Starting from easily available aryl halides and olefins, versatile building blocks can be prepared in a straightforward manner. The generality and functional group tolerance of this novel protocol is demonstrated.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.forename: Anke
authors.initials: A
authors.lastname: Spannenberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Schulz
authors.forename: Haijun
authors.initials: H
authors.lastname: Jiao
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller