title: [Preparation and characterization of curcumin polybutylcyanoacrylate nanoparticles].
abstract: OBJECTIVE
  To prepare curcumin polybutylcyanoacrylate nanoparticles (Cur-PBCNs) and evaluate its characteristics.
  
  
  METHODS
  Cur-PBCNs were prepared by emulsion polymerization, and the formulation was optimized by L16 (4(3)) orthogonal design test with entrapment efficiency and drug loading as indices. In addition, its characteristics were investigated.
  
  
  RESULTS
  The nanoparticles were spherical in appearance under transmission electron microscope (TEM). The mean diameter of the nanoparticles was 93.8 nm, the mean entrapment efficiency was (50.4 +/- 2.2)%, the mean drug-loading was (33.5 +/- 0.9)% and the Zeta potential was -6.81 mV. The total drug release was 34.74% in 2 hours followed by a sustained release in vitro for Cur-PBCNs, and the in vitro release profile of the nanoparticles was fit for two phases kinetics equation: 100 - Q = 4.5235e(-0.1724t) + 4.1641e(-0.0114t).
  
  
  CONCLUSIONS
  The optimal Cur-PBCNs show good characteristics and sustained release character in vitro.
authors.affiliation: College of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: Xiu-qing
authors.initials: XQ
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Fan-ping
authors.initials: FP
authors.lastname: Zhu
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Ding
authors.forename: Ying-jie
authors.initials: YJ
authors.lastname: Zhai
authors.forename: Guang-xi
authors.initials: GX
authors.lastname: Zhai
mesh_terms: D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D004659:Enbucrilate / Q000008:administration & dosage / Q000737:chemistry*; D020939:Zingiber officinale / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D011092:Polyethylene Glycols; D004659:Enbucrilate; D003474:Curcumin