Treatment of severe lactic acidosis during the pre-anhepatic stage of liver transplant surgery with intraoperative hemodialysis.
Severe uncompensated lactic acidosis manifesting during the pre-anhepatic stage of orthotopic liver transplant surgery is an uncommon event, but it poses serious concern because of the additional lactate production and impaired elimination by the liver that develops during the anhepatic and allograft reperfusion stages of the procedure. A man with end-stage liver disease secondary to hepatitis C and hemochromatosis and normal renal function, who developed severe lactic acidosis in the pre-anhepatic stage of liver transplantation, was treated successfully with intraoperative, continuous venovenous hemodialysis. Hemodialysis effectively corrected the patient's lactic acidosis and removed lactate, which contributed to hemodynamic stability during the anhepatic and graft reperfusion stages of his liver transplant surgery.
Vitin
Alexander
A
Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA. vitin@u.washington.edu
Muczynski
Kimberly
K
Bakthavatsalam
Ramasamy
R
Martay
Kenneth
K
Dembo
Gregory
G
Metzner
Julia
J
D000140:Acidosis, Lactic / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D058625:End Stage Liver Disease / Q000628:therapy / Q000821:virology; D006432:Hemochromatosis / Q000150:complications; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D012720:Severity of Illness Index