title: Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice.
abstract: Significant increase in the salivary gland weight was observed after exposure to single therapeutic dose of 3.7 MBq of 131I in mice. Pre-supplementation of antioxidants, O. sanctum leaf extract, turmeric extract and vitamin E for 15 days before 131I exposure demonstrated significant reduction in the salivary gland weight. No major histopathological changes were observed in the salivary gland of experimental animals at 24 h of exposure. Micronuclei index in the bone marrow of polychromatic (PCEs) and normochromatic erythrocytes (NCEs) remained unchanged in all the experimental groups. However, PCE/NCE ratio in the bone marrow decreased significantly in all the 131I exposed animals irrespective of antioxidant supplementation status. The normalization of salivary gland weight by antioxidant pre-supplementation in radioiodine exposed mice is suggestive of the possible ameliorating effect of antioxidants on the salivary gland weight recommending further detailed studies regarding the functional aspect of the salivary gland in higher animals.
authors.affiliation: Radiation Medicine Centre, Bio-Medical Group, Bhabha Atomic Research Centre, c/o Tata Memorial Hospital Annexe, Parel, Mumbai 400 012, India. umapat@yahoo.com
authors.forename: Uma S
authors.initials: US
authors.lastname: Bhartiya
authors.forename: Lebana J
authors.initials: LJ
authors.lastname: Joseph
authors.forename: Yogita S
authors.initials: YS
authors.lastname: Raut
authors.forename: Badanidiyoor S
authors.initials: BS
authors.lastname: Rao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D030024:Curcuma; D019587:Dietary Supplements; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D031339:Ocimum / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011837:Radiation-Protective Agents / Q000494:pharmacology; D012469:Salivary Glands / Q000187:drug effects* / Q000528:radiation effects; D024505:Tocopherols / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D007457:Iodine Radioisotopes; D010936:Plant Extracts; D011837:Radiation-Protective Agents; C012596:turmeric extract; D024505:Tocopherols