title: Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats.
abstract: Acrylamide (ACR) has been shown to be a neurotoxic agent for both laboratory animals and human. The present study aimed at synthesizing new functionalized melatonin derivatives bearing promising heterocyclic moiety that could be expected to have protective effect against ACR-induced neurotoxicity in adult female rats. The novel melatonin derivatives 4, 6, 7 and 11 were synthesized and their chemical structures were confirmed by studying their analytical and spectral data. The administration of ACR [i.p., 50 mg kg(-1) body weight (b. wt.)] alone resulted in significant increase in brain malondialdehyde level (MDA) and lactate dehydrogenase (LDH) activity whereas it caused significant decrease in brain monoamines levels and antioxidant enzymes activity. Treatment with melatonin derivatives 4, 6, 7 and 11 (i.p., 50 mg kg(-1) b. wt) prior to ACR produced significant decrease in brain MDA level and LDH activity with concomitant significant increase in brain monoamines and antioxidant enzymes activity. It could be concluded that the new synthesized melatonin derivatives exhibited promising protective activity against ACR-induced neurotoxicity.
authors.affiliation: Hormones Department, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: Hanaa H
authors.initials: HH
authors.lastname: Ahmed
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Elmegeed
authors.forename: el-Sayed M
authors.initials: el-SM
authors.lastname: el-Sayed
authors.forename: Mervat M
authors.initials: MM
authors.lastname: Abd-Elhalim
authors.forename: Wafaa Gh
authors.initials: WG
authors.lastname: Shousha
authors.forename: Reham W
authors.initials: RW
authors.lastname: Shafic
mesh_terms: D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000975:Antioxidants; D016877:Oxidants; D020106:Acrylamide; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D008550:Melatonin