Does arsenic in soil contribute to arsenic urinary concentrations in a French population living in a naturally arsenic contaminated area?
A cross sectional study using environmental and biological samples was implemented to assess the association between arsenic (As) concentrations in the environment and urinary As levels of residents living in an area where the soil is naturally As rich. As was measured in drinking water, atmospheric particulate matter, and soil and a geographic information system was used to assign environmental concentrations closest to the participants' dwellings and the sum of inorganic As and metabolites in urine samples. The only potential source of As environmental contamination was from soil with a range of 13-131 mg As/kg of dry matter. As(V) was the only species present among As extracted from the analyzed soil samples. The chemical extraction showed a poor mobility of As soil. There was no difference between child and teenager, and adult urinary As concentrations, though men had higher urinary As concentrations than women (p<0.001). Given the important differences in lifestyle between 7-18 year olds, men, and women, these groups were analyzed separately. Whilst we were unable to find a stable model for the 7-18 year old group, for the adult men group we found that seafood consumption in the 3 days prior to the investigation (p=0.02), and beer (p=0.03) and wine consumption in the 4 days before the study, were associated with As urinary levels (μg/L). In adult women, creatinine was the only variable significantly associated with As urinary concentration (μg/L). The concentrations we measured in soils were variable and although high, only moderately so and no link between As concentrations in the soil and urinary As concentrations could be found for either men or women. Some individual factors explained half of the variability of adult men urinary As levels. The unexplained part of the variability should be searched notably in As mobility in soil and uncharacterized human behavior.
Fillol
Clémence
C
Université Paris Descartes, Laboratoire Santé Publique et Environnement, EA 4064, Paris, France. c.fillol@invs.sante.fr
Dor
Frédéric
F
Clozel
Blandine
B
Goria
Sarah
S
Seta
Nathalie
N
D000293:Adolescent; D000328:Adult; D001151:Arsenic / Q000032:analysis / Q000652:urine*; D002648:Child; D004784:Environmental Monitoring; D005260:Female; D005602:France; D005618:Fresh Water / Q000737:chemistry; D040362:Geographic Information Systems; D006798:Housing; D006801:Humans; D008297:Male; D052638:Particulate Matter / Q000032:analysis; D012989:Soil Pollutants / Q000032:analysis / Q000652:urine*; D014874:Water Pollutants, Chemical / Q000032:analysis; D055815:Young Adult
D052638:Particulate Matter; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D001151:Arsenic