title: Motion compensated generalized reconstruction for free-breathing dynamic contrast-enhanced MRI.
abstract: The analysis of abdominal and thoracic dynamic contrast-enhanced MRI is often impaired by artifacts and misregistration caused by physiological motion. Breath-hold is too short to cover long acquisitions. A novel multipurpose reconstruction technique, entitled dynamic contrast-enhanced generalized reconstruction by inversion of coupled systems, is presented. It performs respiratory motion compensation in terms of both motion artefact correction and registration. It comprises motion modeling and contrast-change modeling. The method feeds on physiological signals and x-f space properties of dynamic series to invert a coupled system of linear equations. The unknowns solved for represent the parameters for a linear nonrigid motion model and the parameters for a linear contrast-change model based on B-splines. Performance is demonstrated on myocardial perfusion imaging, on six simulated data sets and six clinical exams. The main purpose consists in removing motion-induced errors from time-intensity curves, thus improving curve analysis and postprocessing in general. This method alleviates postprocessing difficulties in dynamic contrast-enhanced MRI and opens new possibilities for dynamic contrast-enhanced MRI analysis.
authors.affiliation: IADI Lab, INSERM-U947, Nancy-Universite, University Hospital Nancy, Nancy, France.
authors.forename: M
authors.initials: M
authors.lastname: Filipovic
authors.forename: P-A
authors.initials: PA
authors.lastname: Vuissoz
authors.forename: A
authors.initials: A
authors.lastname: Codreanu
authors.forename: M
authors.initials: M
authors.lastname: Claudon
authors.forename: J
authors.initials: J
authors.lastname: Felblinger
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003287:Contrast Media; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography; D008536:Meglumine; D009038:Motion; D055414:Myocardial Perfusion Imaging; D009942:Organometallic Compounds; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine