title: Investigating possible changes in protein structure during dendrimer-protein binding.
abstract: Building on our previous results that revealed a sized based mechanism for dendrimer/protein binding, the mechanism of complexation is further probed using CD spectroscopy; the results demonstrate that dendrimer/protein binding is not accompanied by changes in the protein's structure and that binding takes place on the interfacial area/active site entrance.
authors.affiliation: Chemistry Department, University of Sheffield, Sheffield, UKS3 7HF.
authors.forename: F
authors.initials: F
authors.lastname: Chiba
authors.forename: G
authors.initials: G
authors.lastname: Mann
authors.forename: L J
authors.initials: LJ
authors.lastname: Twyman
mesh_terms: D002918:Chymotrypsin / Q000737:chemistry* / Q000378:metabolism*; D002942:Circular Dichroism; D045304:Cytochromes c / Q000737:chemistry* / Q000378:metabolism*; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D050091:Dendrimers; D045304:Cytochromes c; D002918:Chymotrypsin