"Venopathy" at work: recasting neointimal hyperplasia in a new light.
Hemodialysis vascular access is a unique form of vascular anastomosis. Although it is created in a unique disease state, it has much to offer in terms of insights into venous endothelial and anastomotic biology. The development of neointimal hyperplasia (NH) has been identified as a pathologic entity, decreasing the lifespan and effectiveness of hemodialysis vascular access. Subtle hints and new data suggest a contrary idea-that NH, to some extent an expected response, if controlled properly, may play a beneficial role in the promotion of maturation to a functional access. This review attempts to recast our understanding of NH and redefine research goals for an evolving discipline that focuses on a life-sustaining connection between an artery and vein.
Yevzlin
Alexander S
AS
Departments of Medicine and Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA.
Chan
Micah R
MR
Becker
Yolanda T
YT
Roy-Chaudhury
Prabir
P
Lee
Timmy
T
Becker
Bryan N
BN
D000818:Animals; D001164:Arteriovenous Fistula / Q000209:etiology / Q000473:pathology; D002408:Catheters, Indwelling / Q000009:adverse effects*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D017539:Tunica Intima / Q000473:pathology* / Q000503:physiopathology; D014654:Vascular Patency; D014680:Veins / Q000473:pathology*