title: Effect of body mass index reduction on serum hepcidin levels and iron status in obese children.
abstract: Iron deficiency has been linked to obesity. Hepcidin is the main regulator of iron homeostasis and is higher in obese children compared to controls. To gain insight into the link between obesity and hepcidin, we performed an intervention study in 15 obese children. These children were subjected to a 6-month weight loss program and underwent physical examination and iron status and absorption as well as hepcidin, interleukin-6 and leptin serum levels evaluation at baseline and after the weight loss program. After the program all children reduced their body mass index standard deviation score (BMI SDS) of at least 0.5. We observed a significant decrease in hepcidin (P=0.003) and leptin levels (P=0.005), and a significant increase in iron absorption (P=0.02). A direct correlation between the measure of hepcidin and leptin reduction was observed and this correlation appeared significant (r²=0.33, P=0.003) when adjusted for interleukin-6 and BMI SDS variations. In conclusion, we have shown that, in obese children, BMI reduction is associated with hepcidin reduction, potentially improving iron status and absorption. Implications of these findings could be considered in the management of obese children with poor iron status.
authors.affiliation: Department of Pediatrics 'F. Fede', Seconda Università degli Studi di Napoli, Napoli, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Amato
authors.forename: N
authors.initials: N
authors.lastname: Santoro
authors.forename: P
authors.initials: P
authors.lastname: Calabrò
authors.forename: A
authors.initials: A
authors.lastname: Grandone
authors.forename: D W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: L
authors.initials: L
authors.lastname: Perrone
authors.forename: E Miraglia
authors.initials: EM
authors.lastname: del Giudice
mesh_terms: D000293:Adolescent; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D005260:Female; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D007558:Italy; D008297:Male; D009765:Obesity / Q000097:blood*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron