Neuroprotective strategies for intracerebral hemorrhage: trials and translation.
Intracerebral hemorrhage is a devastating neurological illness with few treatment options. In the past 10 years, 6 clinical trials have been completed examining the potential role that putative neuroprotective agents might play in improving outcome. Although each of these trials failed to show a benefit, animal research continues to supply the translational pipeline and 5 clinical trials evaluating neuroprotective agents in intracerebral hemorrhage are currently ongoing. Despite initial failures, neuroprotective agents continue to show promise in the treatment of intracerebral hemorrhage, but improvements in clinical trial design and more accurate predictive outcome models are necessary.
Kellner
Christopher P
CP
Department of Neurological Surgery, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
Connolly
E Sander
ES
D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*
D018696:Neuroprotective Agents