[Genome-wide scanning in the study of risk for cerebral stroke].
The role of genetic predisposition to the formation of most multifactorial diseases, including stroke, was demonstrated in a number of investigations. To determine the individual genetic risk of a polygenic disease, the candidate gene approach is used most often. It is based on the analysis of polymorphic variants of certain genes taking into consideration the function of their protein product. But this approach is limited by the analysis of defined genes and does not detect new groups of genes, which involved in the pathogenesis of cerebral stroke. Genome-wide association study is a wide-range analysis of whole-genome polymorphisms, which allows to compare the distribution of allele frequencies in stroke patients and healthy individuals. The use of this method for the determination of individual genetic risk of acute stroke allows to perform molecular-genetic screening of most significant markers of stroke predisposition; to determine patients with the highest risk of stroke and to perform the mass health examination with preventive therapy prescription. The genome-wide association study to determine the individual genetic risk of stroke, taking into account ethnic origin, is performed in the Russian Federation since 2008 on the basis of the Neurological clinic of the Russian State Medical University in collaboration with the Institute of Molecular Genetics, Russian Academy of Sciences.
Skvortsova
V I
VI
Limborskaia
S A
SA
Shetova
I M
IM
Slominskiĭ
P A
PA
Botsina
A Iu
AIu
Shamalov
N A
NA
Tupitsyna
T V
TV
D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D011110:Polymorphism, Genetic; D020521:Stroke / Q000235:genetics*
D005819:Genetic Markers