Granada virus: a natural phlebovirus reassortant of the sandfly fever Naples serocomplex with low seroprevalence in humans.
A new member of the phlebovirus genus, tentatively named Granada virus, was detected in sandflies collected in Spain. By showing the presence of specific neutralizing antibodies in human serum collected in Granada, we show that Granada virus infects humans. The analysis of the complete genome of Granada virus revealed that this agent is likely to be a natural reassortant of the recently described Massilia virus (donor of the long and short segments) with a yet unidentified phlebovirus (donor of the medium segment).
Collao
Ximena
X
Department of Virology, National Center of Microbiology, Institute of Health Carlos III, Madrid, Spain. ximecf1@hotmail.com
Palacios
Gustavo
G
de Ory
Fernando
F
Sanbonmatsu
Sara
S
Pérez-Ruiz
Mercedes
M
Navarro
José María
JM
Molina
Ricardo
R
Hutchison
Stephen K
SK
Lipkin
W Ian
WI
Tenorio
Antonio
A
Sánchez-Seco
María Paz
MP
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D002522:Chlorocebus aethiops; D005260:Female; D016679:Genome, Viral; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D010217:Phlebotomus Fever / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D011576:Psychodidae / Q000821:virology*; D016865:Reassortant Viruses; D029301:Sandfly fever Naples virus / Q000145:classification* / Q000235:genetics* / Q000276:immunology; D016036:Seroepidemiologic Studies; D014709:Vero Cells
D000914:Antibodies, Viral