title: The value of initial lactate in patients with carbon monoxide intoxication: in the emergency department.
abstract: Patients with carbon monoxide (CO) poisoning have been found to have a correlation between initial clinical severity on admission and blood lactate levels. Recently, it is suggested that the lactate level may be a useful prognostic factor in cases study. The purpose of this study was to determine whether lactate levels were associated with the short-term outcome of patients with CO poisoning and identify the characteristics of patients with high initial lactate levels. Eighty patients that presented to the Chonnam National University Hospital after CO poisoning, over 5 years, were enrolled in this retrospective study. Fifty-six (70.0%) patients had high lactate (>2.1 mmo/L) on admission. Thirty-three (41.3%) patients had medical complications and one patient (1.3%) died. The patients with high initial lactate had an altered mental status more frequently, higher WBC, glucose and carboxyhemoglobin (COHb), and lower base deficit on admission. The multivariate analysis showed that lactate was an independent factor associated with serious complications and the need for intensive medical treatment, along with advanced age, WBC, and altered mental status on admission. The results of this study show that the initial lactate was useful for patient prognosis after CO poisoning.
authors.affiliation: Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, South Korea.
authors.forename: Jeong Mi
authors.initials: JM
authors.lastname: Moon
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Shin
authors.forename: Byeong Jo
authors.initials: BJ
authors.lastname: Chun
mesh_terms: D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000150:complications / Q000628:therapy; D015331:Cohort Studies; D004632:Emergency Medical Services / Q000379:methods*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D019344:Lactic Acid