title: The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field.
abstract: Leukotrienes (LTs) are potent biological proinflammatory mediators. LTC4, LTD4, and LTE4 are more frequently involved in chronic inflammatory responses and exert their actions binding to a cysteinyl-LT 1 (CysLT1) receptor and a cysteinyl-LT 2 (CysLT2) receptor. LTs receptor antagonists available for clinical use demonstrate high-affinity binding to the CysLT1 receptor. In this paper the employment of anti-LTs in allergic cutaneous diseases is analyzed showing that several studies have recently reported a beneficial effects of these agents (montelukast and zafirlukast as well as zileuton) for the treatment of some allergic cutaneous related diseases-like chronic urticaria and atopic eczema although their proper application remains to be established.
authors.affiliation: Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Piazza Giulio Cesare, 70124 Bari, Italy. e.nettis@allergy.uniba.it
authors.forename: Eustachio
authors.initials: E
authors.lastname: Nettis
authors.forename: Maddalena
authors.initials: M
authors.lastname: D'Erasmo
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Di Leo
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Calogiuri
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Montinaro
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferrannini
authors.forename: Angelo
authors.initials: A
authors.lastname: Vacca
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000818:Animals; D003521:Cyclopropanes; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D048448:Phenylcarbamates; D011804:Quinolines / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy*; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000627:therapeutic use
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D011804:Quinolines; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds; C093875:montelukast; C062735:zafirlukast