title: Interleukin-6 promoter polymorphism (-174 G/C) in Indian patients with chronic periodontitis.
abstract: Recent studies have focused on genetic polymorphism of the interleukin-6 (IL-6) gene, which has led to a better understanding of the intricate interactions between host response, microorganisms, and genetics. Genotype prevalence appears to vary by the race and ethnicity of the population studied. We used a polymerase chain reaction technique to determine the prevalence of single nucleotide polymorphism in IL-6 at position -174 G>C in a population of 30 South Indians. Blood samples were collected from 15 chronic periodontitis patients and 15 healthy controls. The results showed that the G/G genotype was significantly more frequent in the chronic periodontitis group and that the C/C genotype was significantly more frequent in the control group (P = 0.0069 for both). The G allele was more frequent in chronic periodontitis patients (76.67%), whereas the C allele was more frequent in the control group (73.33%). Among chronic periodontitis patients, the odds ratio for having the G allele, as compared with the controls, was 9.04. In this population, the presence of the G/G genotype of IL-6 (-174) might increase susceptibility to chronic periodontitis, whereas the C/C genotype may have a protective effect.
authors.affiliation: Department of Periodontics, PMNM Dental College and Hospital, Bagalkot, India.
authors.forename: Nagaraj B
authors.initials: NB
authors.lastname: Kalburgi
authors.forename: Aman
authors.initials: A
authors.lastname: Bhatia
authors.forename: Shivaprasad
authors.initials: S
authors.lastname: Bilichodmath
authors.forename: Sudhir R
authors.initials: SR
authors.lastname: Patil
authors.forename: Sachin B
authors.initials: SB
authors.lastname: Mangalekar
authors.forename: Kishore
authors.initials: K
authors.lastname: Bhat
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D055113:Chronic Periodontitis / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044465:White People / Q000235:genetics
chemical_list: D015850:Interleukin-6