title: [Tea polyphenols protects the testis following testicular torsion/detorsion in rats].
abstract: OBJECTIVE
  To investigate the protective effect of tea polyphenols against testis injury induced by unilateral testicular torsion/detorsion.
  
  
  METHODS
  Twenty-four healthy male Wistar rats were equally randomized into Group I, sham operation, and Groups II and III, subjected to left lateral 720 degrees testicular torsion, followed by detorsion at 6 hours. Intraperitoneal injection of isotonic saline and polyphenols was initiated 30 minutes prior to detorsion and maintained at a low dose for 3 days postoperatively. All the rats were fed under the same condition and sacrificed 5 days later, the left torsional testes harvested for the detection of the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) and the apoptosis of spermatogenic cells by TUNEL.
  
  
  RESULTS
  Significant differences were observed among Groups I, I and III in the levels of SOD in the left torsional testes ([285.00 +/- 22.51], [242.00 +/- 17.62] and [261.00 +/- 10.01] nU/mg, P < 0.05), as well as in the levels of MDA ([1.81 +/- 0.20], [4.34 +/- 0.34] and [2.94 +/- 0.38] nU/mg, P < 0.05). And the apoptosis indexes of spermatogenic cells were 6.64 +/- 1.82, 55.23 +/- 6.46 and 31.84 +/- 5.56 in the three groups, significantly reduced in Group III as compared with Group II (P < 0.05).
  
  
  CONCLUSIONS
  Tea polyphenols has a protective effect against testicular torsion-induced ischemic reperfusion injury in rats.
authors.affiliation: Department of Urology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China. heqingxin54@163.com
authors.forename: Qing-Xin
authors.initials: QX
authors.lastname: He
authors.forename: Yan-Gang
authors.initials: YG
authors.lastname: Zhang
authors.forename: Xuan
authors.initials: X
authors.lastname: Hu
authors.forename: Yun-Tong
authors.initials: YT
authors.lastname: Guo
mesh_terms: D000818:Animals; D017209:Apoptosis; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013086:Spermatic Cord Torsion / Q000378:metabolism* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D013662:Tea / Q000737:chemistry*; D013737:Testis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D008315:Malondialdehyde; D013482:Superoxide Dismutase