title: Clinicopathological features and prognosis of Chinese patients with acute post-streptococcal glomerulonephritis.
abstract: OBJECTIVE
  To investigate clinicopathological and prognostic differences between adults and children with acute post-streptococcal glomerulonephritis (APSGN).
  
  
  METHODS
  A retrospective case series of 112 patients with APSGN was undertaken. Patients were divided into two groups according to age: adults aged more than 17 years and children aged less than 15 years.
  
  
  RESULTS
  The incidence of APSGN, especially in adults, has decreased in the past three decades. Children have had a higher incidence of macroscopic haematuria than adults (58.3% vs 32.7%, P < 0.05). Laboratory test showed that red blood cell count of urine sediment in children was more significant. On light microscopy, adults had more global glomerulosclerosis, tubular basement membrane thickening, tubular atrophy and interstitial fibrosis, while children had more glomerular infiltrating neutrophils and monocytes and cellular casts. Immunofluorescence microscopy showed that classical staining was seen more in children. The short-term prognoses were good in both children and adults. But the recovery rate of proteinuria in children was faster than that in adults.
  
  
  CONCLUSIONS
  Adults with APSGN had similar clinical features as children except that children had more significant haematuria. On pathology, adults had more outstanding chronic changes by light microscopy and more untypical staining by immunofluorescence.
authors.affiliation: Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, China.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Luo
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chen
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jinquan
authors.initials: J
authors.lastname: Wang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Liu
authors.forename: Leishi
authors.initials: L
authors.lastname: Li
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D001706:Biopsy; D016009:Chi-Square Distribution; D002648:Child; D002681:China; D003165:Complement System Proteins / Q000276:immunology; D004906:Erythrocyte Count; D005260:Female; D005921:Glomerulonephritis / Q000208:ethnology / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D006417:Hematuria / Q000208:ethnology / Q000382:microbiology; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D011379:Prognosis; D011507:Proteinuria / Q000208:ethnology / Q000382:microbiology; D013290:Streptococcal Infections / Q000208:ethnology / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013997:Time Factors; D016482:Urinalysis; D055815:Young Adult
chemical_list: D003165:Complement System Proteins