Streptomyces coelicolor increases the production of undecylprodigiosin when interacted with Bacillus subtilis.
Undecylprodigiosin has antimicrobial, immunosuppressive and anticancer properties. Pure cultures of Streptomyces coelicolor produce only low concentrations of undecylprodigiosin. We have therefore sought to increase this by interacting the cells with a bacterium. When interacted with live or heat-killed cells of Bacillus subtilis, Streptomyces coelicolor A3 (2), increased undecylprodigiosin production in shake-flasks and in a 2 l bioreactor. An inoculum of 2.5% (v/v) B. subtilis containing 10(8) cells/ml added at the beginning of the S. coelicolor culture gave the best results for undecylprodigiosin production. In the shake-flasks, the increase was 175-211% and in the bioreactor, 256% in comparison to the pure cultures of S. coelicolor.
Luti
Khalid Jaber Kadhum
KJ
School of Chemical Engineering and Analytical Science, The Mill, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Mavituna
Ferda
F
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000898:Antibiosis; D001412:Bacillus subtilis / Q000502:physiology*; D001709:Biotechnology / Q000379:methods*; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000502:physiology*
D000900:Anti-Bacterial Agents; C047347:undecylprodigiosin; D011353:Prodigiosin