Semiconservative quasispecies equations for polysomic genomes: the general case.
This paper develops a formulation of the quasispecies equations appropriate for polysomic, semiconservatively replicating genomes. This paper is an extension of previous work on the subject, which considered the case of haploid genomes. Here, we develop a more general formulation of the quasispecies equations that is applicable to diploid and even polyploid genomes. Interestingly, with an appropriate classification of population fractions, we obtain a system of equations that is formally identical to the haploid case. As with the work for haploid genomes, we consider both random and immortal DNA strand chromosome segregation mechanisms. However, in contrast to the haploid case, we have found that an analytical solution for the mean fitness is considerably more difficult to obtain for the polyploid case. Accordingly, whereas for the haploid case we obtained expressions for the mean fitness for the case of an analog of the single-fitness-peak landscape for arbitrary lesion repair probabilities (thereby allowing for noncomplementary genomes), here we solve for the mean fitness for the restricted case of perfect lesion repair.
Itan
Eran
E
Department of Chemistry, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Tannenbaum
Emmanuel
E
D001703:Biophysics / Q000379:methods; D002875:Chromosomes / Q000648:ultrastructure*; D004247:DNA / Q000235:genetics*; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics; D016678:Genome; D006238:Haploidy; D006801:Humans; D015233:Models, Statistical; D011123:Polyploidy; D012100:Reproduction, Asexual; D013045:Species Specificity
D004269:DNA, Bacterial; D004247:DNA