title: Carrier mediated protein and peptide stabilization.
abstract: Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role in stabilization of proteins. Incorporation of the protein and peptides into a particulate carrier can protect it against degradation in vitro and in vivo, the release can be controlled,and it also offers possibilities for targeting. This review has focused on a wide range of bioactive carriers used in protein stabilization during long time storage. Bioactive carriers can protect the bioactives from degradation, resulting in increased bioavailability of protein.
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University,Sagar-470 003, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Tiwari
authors.forename: Virendra
authors.initials: V
authors.lastname: Gajbhiye
authors.forename: Rajeev
authors.initials: R
authors.lastname: Sharma
authors.forename: Narendra Kumar
authors.initials: NK
authors.lastname: Jain
mesh_terms: D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D050091:Dendrimers; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D008081:Liposomes; D008863:Microspheres; D053758:Nanoparticles; D037742:Nanotubes, Carbon; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D050091:Dendrimers; D004337:Drug Carriers; D005079:Excipients; D008081:Liposomes; D037742:Nanotubes, Carbon; D010455:Peptides; D011506:Proteins