Post-transcriptional regulation of noise in protein distributions during gene expression.
The intrinsic stochasticity of gene expression can lead to a large variability of protein levels across a population of cells. Variability (or noise) in protein distributions can be modulated by cellular mechanisms of gene regulation; in particular, there is considerable interest in understanding the role of post-transcriptional regulation. To address this issue, we propose and analyze a stochastic model for post-transcriptional regulation of gene expression. The analytical solution of the model provides insight into the effects of different mechanisms of post-transcriptional regulation on the noise in protein distributions. The results obtained also demonstrate how different sources of intrinsic noise in gene expression can be discriminated based on observations of regulated protein distributions.
Jia
Tao
T
Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. tjia@vt.edu
Kulkarni
Rahul V
RV
D005786:Gene Expression Regulation; D007700:Kinetics; D008954:Models, Biological; D016012:Poisson Distribution; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013269:Stochastic Processes; D014158:Transcription, Genetic
D011506:Proteins; D012333:RNA, Messenger