title: The Comparative Toxicogenomics Database: update 2011.
abstract: The Comparative Toxicogenomics Database (CTD) is a public resource that promotes understanding about the interaction of environmental chemicals with gene products, and their effects on human health. Biocurators at CTD manually curate a triad of chemical-gene, chemical-disease and gene-disease relationships from the literature. These core data are then integrated to construct chemical-gene-disease networks and to predict many novel relationships using different types of associated data. Since 2009, we dramatically increased the content of CTD to 1.4 million chemical-gene-disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps (to find comparable genes and chemicals that share toxicogenomic profiles), enriched Gene Ontology terms associated with chemicals, statistically ranked chemical-disease inferences, Venn diagram tools to discover overlapping and unique attributes of any set of chemicals, genes or disease, and enhanced gene pathway data content, among other features. Together, this wealth of expanded chemical-gene-disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. CTD is freely available at http://ctd.mdibl.org.
authors.affiliation: Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
authors.forename: Allan Peter
authors.initials: AP
authors.lastname: Davis
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: King
authors.forename: Susan
authors.initials: S
authors.lastname: Mockus
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Murphy
authors.forename: Cynthia
authors.initials: C
authors.lastname: Saraceni-Richards
authors.forename: Michael
authors.initials: M
authors.lastname: Rosenstein
authors.forename: Thomas
authors.initials: T
authors.lastname: Wiegers
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Mattingly
mesh_terms: D016208:Databases, Factual; D004194:Disease / Q000209:etiology* / Q000235:genetics; D004781:Environmental Exposure; D053263:Gene Regulatory Networks; D005796:Genes; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D012984:Software; D043922:Toxicogenetics
chemical_list: D015386:Hazardous Substances