title: Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.
abstract: Trilateral retinoblastoma (TRB) is a rare condition characterized by an intracranial neuroblastic tumor associated with bilateral or unilateral retinoblastoma (RB). The outcome is almost always fatal. An 18-month-old patient with familial bilateral RB was referred for a pineal lesion detected on a screening by magnetic resonance imaging. The child, considered inoperable by 2 different neurosurgical teams, was treated with conventional chemotherapy (methotrexate, vincristine, vepeside, cyclophosphamide, and carboplatin) plus tandem transplantation (vepeside/carboplatin and thiotepa/mephalan) followed by local radiotherapy. At 80 months from the diagnosis of TRB, the patient is alive and in complete remission, with no neuropsychologic consequences. An early and aggressive treatment may improve the prognosis of TRB.
authors.affiliation: Division of Pediatric Oncology Unit, Ospedale Pediatrico Bambino Gesù, Rome, Italy. deioris@opbg.net
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: De Ioris
authors.forename: Paola
authors.initials: P
authors.lastname: Fidani
authors.forename: Francis L
authors.initials: FL
authors.lastname: Munier
authors.forename: Annalisa
authors.initials: A
authors.lastname: Serra
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ilari
authors.forename: Maya Beck
authors.initials: MB
authors.lastname: Popovic
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Natali
authors.forename: Domitilla Elena
authors.initials: DE
authors.lastname: Secco
authors.forename: Raffaele
authors.initials: R
authors.lastname: Cozza
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D010871:Pinealoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D011829:Radiation Dosage; D011878:Radiotherapy; D012074:Remission Induction; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*