title: [Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations].
abstract: Three genes mutations in which cause familial forms of Alzheimer's disease are known to date:PSEN1, PSEN2 and APP; and APOE gene polymorphism is a strong risk factor for Alzheimer's disease. We have evaluated allele and genotype frequency distribution of rs11136000 polymorphism in clusterin (CLU) gene (or apolipoprotein J, APOJ) in populations of three Russian regions and i nAlzheimhner's diseasepatients. Genome-wideassociation studies in samples from several European populations have recently revealed highly significant association o fCLU gene with AD (p = 8.5 x 10(-10)). We found no differences in allele and genotype frequencies of rs11136000 between populations from Moscow, Ural and Siberia regions. The allele frequencies are close to those in European populations. The genetic association analysis in cohort of Alzheimer's disease patients and normal individuals (>500 individuals ineach group) revealed no significant association of the rs11136000 polymorphism in CLU with Alzheimer's disease in Russian populations. Although our resultsdo not confirm the role of CLU gene as a majorgenetic factor forcommon form of Alzheimer's disease, the data do not rule out the possibility of modest effect of CLU and interaction between CLU and APOE genotypes in etiology of Alzheimer's disease.
authors.forename: S A
authors.initials: SA
authors.lastname: Golenkina
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Gol'tsov
authors.forename: I L
authors.initials: IL
authors.lastname: Kuznetsova
authors.forename: A P
authors.initials: AP
authors.lastname: Grigorenko
authors.forename: T V
authors.initials: TV
authors.lastname: Andreeva
authors.forename: D A
authors.initials: DA
authors.lastname: Reshetov
authors.forename: S S
authors.initials: SS
authors.lastname: Kunizheva
authors.forename: L I
authors.initials: LI
authors.lastname: Shagam
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Morozova
authors.forename: I V
authors.initials: IV
authors.lastname: Goldenkova-Pavlova
authors.forename: Kh
authors.initials: Kh
authors.lastname: Shimshilashvili
authors.forename: A O
authors.initials: AO
authors.lastname: Viacheslavova
authors.forename: G
authors.initials: G
authors.lastname: Faskhutdinova
authors.forename: A É
authors.initials: AÉ
authors.lastname: Gareeva
authors.forename: A G
authors.initials: AG
authors.lastname: Zaĭnullina
authors.forename: É K
authors.initials: ÉK
authors.lastname: Khusnutdinova
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: V A
authors.initials: VA
authors.lastname: Stepanov
authors.forename: A V
authors.initials: AV
authors.lastname: Kolotvin
authors.forename: L M
authors.initials: LM
authors.lastname: Samokhodskaia
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
authors.forename: E I
authors.initials: EI
authors.lastname: Rogaev
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D051152:Clusterin / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012426:Russia / Q000453:epidemiology
chemical_list: C495242:CLU protein, human; D051152:Clusterin