Second high-dose chemotherapy intensification followed by hematopoietic stem cell transplantation applying a novel high-dose topotecan-based regimen in an adult Wilms' tumor patient: case report.
High-dose chemotherapy and hematopoietic stem cell support remains a valuable treatment option for the rare patient population with relapsed Wilms' tumor. Here we report the case of a 22-year-old male patient treated with two cycles of high-dose chemotherapy at relapse after nephrectomy and adjuvant chemotherapy; the first cycle with melphalan--etoposide--carboplatin and the second with a novel preparative regimen incorporating high-dose topotecan (topotecan--cyclophosphamide--melphalan). A detailed discussion and literature review pertaining to that case is provided.
Daladimos
Theodoros
T
Department of Medicine, Second Division of Medical Oncology, Metaxa Cancer Hospital, 51 Botassi Street, Piraeus, Greece.
Theotikos
Evangelos
E
Athanasopoulos
Aggelos
A
Tsakonas
George
G
Karabelis
Athanasios
A
Mylonakis
Nikolaos
N
Kosmas
Christos
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009392:Nephrectomy; D019772:Topotecan / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy* / Q000601:surgery*; D055815:Young Adult
D005047:Etoposide; D019772:Topotecan; D003520:Cyclophosphamide; D016190:Carboplatin; D008558:Melphalan