title: Fluoroquinolone prophylaxis against febrile neutropenia in areas with high fluoroquinolone resistance--an Asian perspective.
abstract: Febrile neutropenia remains a major cause of morbidity and mortality in patients receiving chemotherapy. Major prophylactic strategies include granulocyte colony-stimulating factor and antibiotics, the most widely used of which are fluoroquinolones. While fluoroquinolone prophylaxis has been shown to be effective in areas where fluoroquinolone resistance is low, this same efficacy has not been proven in areas where resistance is high, such as in Asia. Given the increase in antimicrobial resistance with the use of prophylaxis, the risks and benefits of this strategy need to be carefully considered. This review presents the evidence for and against fluoroquinolone prophylaxis in areas of high fluoroquinolone resistance.
authors.affiliation: Department of Medicine, National University Health System, Singapore General Hospital, Singapore.
authors.forename: Esther Shu-Ting
authors.initials: ES
authors.lastname: Ng
authors.forename: Yixin
authors.initials: Y
authors.lastname: Liew
authors.forename: Liang Piu
authors.initials: LP
authors.lastname: Koh
authors.forename: Li Yang
authors.initials: LY
authors.lastname: Hsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001208:Asia; D044466:Asian People; D004351:Drug Resistance; D005334:Fever / Q000517:prevention & control*; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones