title: Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy.
abstract: OBJECTIVE
  We aimed to determine the changes in neural correlates of auditory information processing such as auditory detection, encoding, and sensory discrimination in pediatric patients with intractable epilepsy.
  
  
  METHODS
  In this magnetoencephalography (MEG) study, 10 patients and 10 age- and gender-matched healthy controls were investigated with the multi-feature mismatch negativity (MMN) paradigm. Latencies and amplitudes of M100, M150, M200, and MMN event-related fields were evaluated.
  
  
  RESULTS
  All event-related fields in response to standard stimuli (M100, M150 and M200) and responses to occasional five deviant sounds, deviating from the standard stimuli either in duration, frequency, intensity, location, or by including a silent gap were reduced in amplitude in epilepsy patients compared with healthy controls.
  
  
  CONCLUSIONS
  Our study suggests that auditory information processing is impaired in patients with drug-resistant epilepsy, being evident both in stimulus feature encoding (as reflected by changes of early event-related components, e.g., M100) and in cortical sound discrimination (as reflected by MMNm). The neural changes involving diminished M100 as well as MMNms for all five deviant sound types suggest wide-spread auditory information processing impairments in these patients.
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. milena.korostenskaja@cchmc.org
authors.forename: Milena
authors.initials: M
authors.lastname: Korostenskaja
authors.forename: Maria
authors.initials: M
authors.lastname: Pardos
authors.forename: Hisako
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Teija
authors.initials: T
authors.lastname: Kujala
authors.forename: Paul
authors.initials: P
authors.lastname: Horn
authors.forename: Douglas
authors.initials: D
authors.lastname: Rose
authors.forename: Anna
authors.initials: A
authors.lastname: Byars
authors.forename: David
authors.initials: D
authors.lastname: Brown
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Seo
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Vannest
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.forename: Ton
authors.initials: T
authors.lastname: Degrauw
authors.forename: Risto
authors.initials: R
authors.lastname: Näätänen
authors.forename: Ki H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D001303:Auditory Cortex / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D003265:Contingent Negative Variation / Q000502:physiology; D018450:Disease Progression; D004827:Epilepsy / Q000150:complications* / Q000473:pathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007360:Intelligence / Q000502:physiology; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D010372:Pediatrics; D013223:Statistics as Topic