Continuous-flow synthesis of vitamin D3.
A highly efficient, two-stage, continuous-flow synthesis of vitamin D(3) from provitamin D(3) was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.
Fuse
Shinichiro
S
Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1-H-101, Ookayama, Meguro-ku, Tokyo 152-8552, Japan.
Tanabe
Nobutake
N
Yoshida
Masahito
M
Yoshida
Hayato
H
Doi
Takayuki
T
Takahashi
Takashi
T
D002762:Cholecalciferol / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003684:Dehydrocholesterols / Q000737:chemistry; D014466:Ultraviolet Rays
D003684:Dehydrocholesterols; D002762:Cholecalciferol; C016705:7-dehydrocholesterol