Age-related normogram for antral follicle count: McGill reference guide.
OBJECTIVE
To produce age-related normograms for antral follicle count in an infertile population without polycystic ovaries.


METHODS
Retrospective cohort analysis.


METHODS
University teaching center.


METHODS
Eighteen hundred sixty-six infertile patients.


METHODS
Baseline transvaginal ultrasound examination between days 2 and 4 of the menstrual cycle.


METHODS
Correlation between age and different percentiles of antral follicle count.


RESULTS
The age-related normogram for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentile of antral follicle count showed a biphasic mode of antral follicle count decline with two different rates of antral follicle count loss: a steep-slope phase (high rate of antral follicle count loss) and a moderate-slope phase (restrained rate of antral follicle count losses). In the low antral follicle count percentiles (3rd, 10th, 25th), the phase of high loss rate of follicles preceded the phase of slow loss rate, whereas in the high antral follicle count percentiles (75th, 90th, 97th) the opposite was found.


CONCLUSIONS
Age-related normograms in infertile women without polycystic ovaries demonstrate a biphasic pattern of decreased antral follicles. These normograms could provide a reference guide for the clinician in consulting with women with infertility. However, future validation with longitudinal data is still needed.
Almog
Benny
B
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Shehata
Fady
F
Shalom-Paz
Einat
E
Tan
Seang Lin
SL
Tulandi
Togas
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D002452:Cell Count / Q000379:methods / Q000592:standards; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D049451:Nomograms; D006080:Ovarian Follicle / Q000166:cytology* / Q000000981:diagnostic imaging / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000473:pathology; D017410:Practice Guidelines as Topic; D012016:Reference Values; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult