title: A versatile and practical microwave-assisted synthesis of sterically hindered N-arylpiperazines.
abstract: A wide-ranging and practical synthesis of structurally diverse, sterically hindered N-arylpiperazines from 2,2'-(4-nitrophenylsulfonylazanediyl) bis(ethane-2,1-diyl) bis(4-nitrobenzenesulfonate) and substituted anilines has been achieved using microwave irradiation in acetonitrile followed by deprotection with PhSH.
authors.affiliation: Temple University School of Pharmacy, Department of Pharmaceutical Sciences, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Gao
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Canney
mesh_terms: D000588:Amines / Q000737:chemistry; D008872:Microwaves; D009584:Nitrogen / Q000737:chemistry*; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000588:Amines; D010879:Piperazines; D009584:Nitrogen