title: [The dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa in the allergic rhinitis rat models].
abstract: OBJECTIVE
  To investigate the dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rat models of allergic rhinitis, at different stages of the process during pathogenesis.
  
  
  METHODS
  One hundred and eighty Sprague-Dawley (SD) rats were randomly divided into three groups, the normal Group A used for contrast and experimental groups: Group B and C, each group were 60 rats. Then, observed the expression of the TGF-beta1 and FGF-2 in the nasal mucosa at different stages of the process by immunohistochemical staining.
  
  
  RESULTS
  The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of the normal Group A was negative, while the Group B and Group C were varying degrees of positive both, and Group B, the level of the TGF-beta1 and FGF-2 were both decline after allergen avoidance, but still more not ability than the expression of the Group B (P < 0.05).
  
  
  CONCLUSIONS
  The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rats models were varying degrees of positive , and it is decline while the allergen avoidance.
authors.affiliation: Department of Otorhinolaryngology, Foshan Hospital of Traditional Medicine, Foshan, 528000, China. linyun02@hotmail.com
authors.forename: Bingbin
authors.initials: B
authors.lastname: Xie
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Liu
authors.forename: Gui
authors.initials: G
authors.lastname: Luo
authors.forename: Jianguo
authors.initials: J
authors.lastname: Liu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhong
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Mei
mesh_terms: D000818:Animals; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2