S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides.
The construction of a library of benzothiaoxazepine-1,1'-dioxides utilizing a one-pot, S(N)Ar diversification-ODCT(50) scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.
Rolfe
Alan
A
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, USA.
Samarakoon
Thiwanka B
TB
Klimberg
Sarra V
SV
Brzozowski
Marek
M
Neuenswander
Benjamin
B
Lushington
Gerald H
GH
Hanson
Paul R
PR
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015394:Molecular Structure; D010077:Oxazepines / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis; D013844:Thiazoles / Q000737:chemistry*
D010077:Oxazepines; D010087:Oxides; D054852:Small Molecule Libraries; D013844:Thiazoles