An investigation of candidate regions for association with bipolar disorder.
We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.
Knight
Jo
J
Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, UK. jo.knight@kcl.ac.uk
Rochberg
Nanette S
NS
Saccone
Scott F
SF
Nurnberger
John I
JI
Rice
John P
JP
D000251:Adenosine Triphosphatases; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D056726:Genetic Association Studies; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers; D000251:Adenosine Triphosphatases