Upper urinary tract infections are associated with RANTES promoter polymorphism.
We evaluated the association between MCP-1, CCR2, RANTES, and CCR5 gene polymorphisms and upper urinary tract infection in 273 children recruited in Northeast Italy. Statistical analysis of RANTES-403 G>A genotype frequencies showed that children carrying the RANTES-403 G allele are at higher risk for urinary tract infection, irrespective of vesicoureteral reflux.
Centi
Sonia
S
Laboratory of Immunopathology and Molecular Biology of the Kidney, Department of Pediatrics Salus Pueri, University of Padua, Italy.
Negrisolo
Susanna
S
Stefanic
Alejandra
A
Benetti
Elisa
E
Cassar
Walburga
W
Da Dalt
Liviana
L
Rigamonti
Waifro
W
Zucchetta
Pietro
P
Montini
Giovanni
G
Murer
Luisa
L
Artifoni
Lina
L
D018946:Chemokine CCL5 / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014552:Urinary Tract Infections / Q000235:genetics*
C483024:CCL5 protein, human; D018946:Chemokine CCL5