Synoxazolidinones A and B: novel bioactive alkaloids from the ascidian Synoicum pulmonaria.
Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.
Tadesse
Margey
M
Norwegian College of Fishery Science, University of Tromsø, Breivika N-9037, Tromsø, Norway. margey.tadesse@uit.no
Strøm
Morten B
MB
Svenson
Johan
J
Jaspars
Marcel
M
Milne
Bruce F
BF
Tørfoss
Veronika
V
Andersen
Jeanette H
JH
Hansen
Espen
E
Stensvåg
Klara
K
Haug
Tor
T
D000818:Animals; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry*; D014561:Urochordata / Q000737:chemistry*
D023303:Oxazolidinones; C555088:synoxazolidinone A; C555089:synoxazolidinone B; D019791:Guanidine