Effect of astragaloside IV on the general and peripartum reproductive toxicity in Sprague-Dawley rats.
Fertility and early embryonic developmental toxicity in rats were evaluated by intravenously administering astragaloside IV (AS-IV) daily at 0.25, 0.5, and 1.0 mg/kg for 4 weeks before mating, throughout the mating period, and continuing to day 6 of gestation period in females. Perinatal toxicity in rats was evaluated on gestational days (GD) 15 to 21 and lactational days LD (LD) 1 to 21. Astragaloside IV had no maternal toxicity at 0.25 to 1.0 mg/kg in rats. Although it has an inhibitory effect on female fertility in F0/F1 rats, AS-IV was devoid of early embryonic developmental toxicity in F0/F1 rats and in the survival parameters of F1 postnatal rats. Maternal AS-IV exposure at the dose of 1.0 mg/kg per d resulted in a significant delay in time for fur development, eye opening, and cliff parry reflex of pups compared to control group (P < .05), whereas it did not affect the memory and learning of F1 pups.
Xuying
Wan
W
Department of Toxicology, Second Military Medical University, Shanghai 200433, PR China. toxiboy2001@yahoo.com.cn.
Jiangbo
Zhu
Z
Yuping
Zhu
Z
Xili
Ma
M
Yiwen
Zheng
Z
Tianbao
Zhang
Z
Weidong
Zhang
Z
D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry / Q000633:toxicity; D027885:Astragalus propinquus; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000633:toxicity; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced; D007248:Infertility, Male / Q000139:chemically induced; D007774:Lactation; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D018812:Paternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000401:mortality; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D012503:Saponins / Q000008:administration & dosage / Q000633:toxicity*; D018675:Toxicity Tests; D014315:Triterpenes / Q000008:administration & dosage / Q000633:toxicity*
D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A; C027492:Huang Qi