title: Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells.
abstract: We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity.
authors.affiliation: College of Life Science and Biotechnology, Dongguk University-Seoul, Seoul 100-756, Korea.
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Jee-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Shanthaveerappa K
authors.initials: SK
authors.lastname: Boovanahalli
authors.forename: Yongseok
authors.initials: Y
authors.lastname: Choi
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Choo
authors.forename: Ick-dong
authors.initials: ID
authors.lastname: Yoo
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Yun
authors.forename: Gye Won
authors.initials: GW
authors.lastname: Lee
authors.forename: Gyu-Yong
authors.initials: GY
authors.lastname: Song
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002087:Butyrates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001578:Benzopyrans; D002087:Butyrates; D008543:Melanins; C101278:decursin