title: Sweat loss prediction using a multi-model approach.
abstract: A new multi-model approach (MMA) for sweat loss prediction is proposed to improve prediction accuracy. MMA was computed as the average of sweat loss predicted by two existing thermoregulation models: i.e., the rational model SCENARIO and the empirical model Heat Strain Decision Aid (HSDA). Three independent physiological datasets, a total of 44 trials, were used to compare predictions by MMA, SCENARIO, and HSDA. The observed sweat losses were collected under different combinations of uniform ensembles, environmental conditions (15-40°C, RH 25-75%), and exercise intensities (250-600 W). Root mean square deviation (RMSD), residual plots, and paired t tests were used to compare predictions with observations. Overall, MMA reduced RMSD by 30-39% in comparison with either SCENARIO or HSDA, and increased the prediction accuracy to 66% from 34% or 55%. Of the MMA predictions, 70% fell within the range of mean observed value ± SD, while only 43% of SCENARIO and 50% of HSDA predictions fell within the same range. Paired t tests showed that differences between observations and MMA predictions were not significant, but differences between observations and SCENARIO or HSDA predictions were significantly different for two datasets. Thus, MMA predicted sweat loss more accurately than either of the two single models for the three datasets used. Future work will be to evaluate MMA using additional physiological data to expand the scope of populations and conditions.
authors.affiliation: Biophysics and Biomedical Modeling Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA. xiaojiang.xu@us.army.mil
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Xu
authors.forename: William R
authors.initials: WR
authors.lastname: Santee
mesh_terms: D001833:Body Temperature Regulation / Q000502:physiology; D016208:Databases, Factual; D015444:Exercise / Q000502:physiology; D005260:Female; D018869:Heat-Shock Response / Q000502:physiology; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008954:Models, Biological; D013546:Sweating / Q000502:physiology*