title: Chronic urticaria is associated with a differential helminth-arthropod-related atopy phenotype.
abstract: The relationship between atopic sensitization and chronic urticaria is still controversial. In this study, we aimed to compare the prevalence of aeroallergen sensitization in chronic urticaria patients with (CU/As+) and without (CU/As-) sensitization against Anisakis simplex. Forty-nine CU/As+ and 80 CU/As- patients were studied and skin prick tests (SPT) were performed against aeroallergens. We assessed sensitization in a subgroup of patients with allergic rhinoconjunctivitis and/or bronchial asthma (RCBA) and compared the prevalence with a control group of 522 non-urticaria patients with RCBA. Forty-five percent of CU/As- and 60.4% of CU/As+ patients displayed positive SPT to at least one aeroallergen. CU/As+ patients had a higher prevalence of sensitization against pollen, mould or dander (PMD) (52.2% vs 29.1%, P < 0.01), whereas the prevalence of house dust mite (HDM) sensitization was not statistically different (26.3% in CU/As- and 36.7% in CU/As+). However, in chronic urticaria patients with RCBA, 53.8% of CU/As- and 57.9% of CU/As+ patients differed in the prevalence of HDM sensitization compared to the control group (33.5%, P = 0.03), whereas no difference could be stated for PMD sensitization. Compared to RCBA patients, both CU/As+ and CU/As- patients have a higher clinically relevant sensitization rate against HDM, thus displaying a differential atopy phenotype.
authors.affiliation: Allergy Service, University Hospital La Princesa, Madrid, Spain. alvarodaschner@gmail.com
authors.forename: Alvaro
authors.initials: A
authors.lastname: Daschner
authors.forename: Marta
authors.initials: M
authors.lastname: Rodero
authors.forename: Consolación
authors.initials: C
authors.lastname: De Frutos
authors.forename: Ana
authors.initials: A
authors.lastname: Valls
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuéllar
mesh_terms: D000328:Adult; D000485:Allergens; D000818:Animals; D017163:Anisakis / Q000276:immunology*; D039741:Antigens, Dermatophagoides / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology; D001249:Asthma / Q000276:immunology* / Q000469:parasitology*; D002908:Chronic Disease; D003233:Conjunctivitis, Allergic / Q000276:immunology / Q000469:parasitology; D005260:Female; D005658:Fungi / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D039981:Pyroglyphidae / Q000276:immunology*; D012189:Retrospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000276:immunology; D012882:Skin Tests; D014581:Urticaria / Q000453:epidemiology* / Q000469:parasitology*
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D000947:Antigens, Helminth