Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients.
Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery. Analysis of their blood samples from the perioperative period showed their MBL levels were abruptly increased at 24 hours after surgery. However, 2 patients had a subsequent drop of MBL at 48 hours, and both expired. These data indicated that the postoperative decrease of MBL may have been related with an unfavorable outcome after cardiac surgery.
Hou
Yunfang Joan
YJ
Department of Anesthesiology, Division of Cardiothoracic Surgery, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA.
Lee
Daniel C
DC
Ko
Wilson
W
Kim
Amie
A
Lee
Jeanie
J
Shevde
Ketan
K
Zhang
Ming
M
D000368:Aged; D006348:Cardiac Surgical Procedures; D017809:Fatal Outcome; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000601:surgery*; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency*; D008875:Middle Aged; D016896:Treatment Outcome
D037601:Mannose-Binding Lectin