title: Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides.
abstract: A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
authors.affiliation: Department of Chemistry, Umeå University, Umeå, Sweden.
authors.forename: J Mikael
authors.initials: JM
authors.lastname: Hillgren
authors.forename: Markus K
authors.initials: MK
authors.lastname: Dahlgren
authors.forename: Tam M
authors.initials: TM
authors.lastname: To
authors.forename: Mikael
authors.initials: M
authors.lastname: Elofsson
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D058947:Bacterial Secretion Systems / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D007659:Ketones / Q000138:chemical synthesis; D018716:Molecular Mimicry; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D000900:Anti-Bacterial Agents; D058947:Bacterial Secretion Systems; D007659:Ketones; D054852:Small Molecule Libraries; D013844:Thiazoles