title: Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: report of a case providing further evidence for a pathogenetic link.
abstract: Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential. Recent cytogenetic studies have shown a t(1;10)(p22;q24) or der(10)t(1;10) in combination with aberrations of chromosome 3 in a limited number of cases of both entities. Here we report a case of a 42-year-old female with a soft tissue tumor of the ankle showing hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor, a der(10)t(1;10), and abnormalities of chromosome 3. This hybrid lesion provides further evidence for a close relationship between these 2 tumor types.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Elco
authors.forename: Adrián
authors.initials: A
authors.lastname: Mariño-Enríquez
authors.forename: John A
authors.initials: JA
authors.lastname: Abraham
authors.forename: Paola
authors.initials: P
authors.lastname: Dal Cin
authors.forename: Jason L
authors.initials: JL
authors.lastname: Hornick
mesh_terms: D000328:Adult; D000842:Ankle; D001706:Biopsy; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006486:Hemosiderosis / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008279:Magnetic Resonance Imaging; D020360:Neoadjuvant Therapy; D019637:Orthopedic Procedures; D018714:Radiotherapy, Adjuvant; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D014178:Translocation, Genetic; D016896:Treatment Outcome