Synthesis and study of controlled release of ofloxacin from polyester conjugates.
New polymeric conjugates were prepared coupling ofloxacin to two-, three-, four and six-arm, star-shaped poly(ɛ-caprolactone) and polylactide. The homopolymers were synthesized via ring-opening polymerization of ɛ-caprolactone, l-lactide and rac-lactide in the presence of glycerol, penthaerythritol, dipentaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. The conjugates were characterized by GPC, MALDI-TOF MS, NMR, IR and viscosity methods. Content of Sn has been investigated in polymers by electrothermal atomic absorption spectrometry. Toxicity of monomers, initiators and polymers were evaluated with bacterial luminescence test and two protozoan assays. The in vitro release of ofloxacin from obtained conjugates in pH 7 was investigated.
Sobczak
Marcin
M
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wum.edu.pl
Nałęcz-Jawecki
Grzegorz
G
Kołodziejski
Wacław L
WL
Goś
Piotr
P
Zółtowska
Karolina
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000633:toxicity; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D008163:Luminescent Measurements; D015242:Ofloxacin / Q000737:chemistry* / Q000633:toxicity; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013054:Spectrophotometry, Atomic; D018675:Toxicity Tests; D014783:Viscosity
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; C016240:polycaprolactone; C033616:poly(lactide); D015242:Ofloxacin