Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms.
In vitro evidence for the isoform-specific partitioning of cadmium and zinc ions between the two C. elegans metallothioneins is presented. This observation is discussed in terms of isoform-specific affinities towards zinc and cadmium and the implications of our study on the in vivo roles of C. elegans metallothioneins.
Leszczyszyn
Oksana I
OI
Department of Chemistry, University of Warwick, Coventry, UK.
Zeitoun-Ghandour
Sukaina
S
Stürzenbaum
Stephen R
SR
Blindauer
Claudia A
CA
D000327:Adsorption; D000818:Animals; D002104:Cadmium / Q000737:chemistry*; D017173:Caenorhabditis elegans / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008668:Metallothionein / Q000737:chemistry*; D020033:Protein Isoforms / Q000737:chemistry*; D013379:Substrate Specificity; D015032:Zinc / Q000737:chemistry*
D007477:Ions; D020033:Protein Isoforms; D002104:Cadmium; D008668:Metallothionein; D015032:Zinc