title: ADC changes in schizophrenia: a diffusion-weighted imaging study.
abstract: Studies using diffusion tensor imaging (DTI) have shown multifocal reduction in anisotropy of white matter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P < 0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P < 0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not support ADC changes to be a marker of white matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder.
authors.affiliation: Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany. igor.nenadic@uni-jena.de
authors.forename: Igor
authors.initials: I
authors.lastname: Nenadic
authors.forename: Gerd
authors.initials: G
authors.lastname: Wagner
authors.forename: Daniel
authors.initials: D
authors.lastname: Güllmar
authors.forename: Claudia
authors.initials: C
authors.lastname: Schachtzabel
authors.forename: Katrin
authors.initials: K
authors.lastname: von Consbruch
authors.forename: Sabine
authors.initials: S
authors.lastname: Köhler
authors.forename: Kathrin
authors.initials: K
authors.lastname: Koch
authors.forename: Martin
authors.initials: M
authors.lastname: Roebel
authors.forename: C Christoph
authors.initials: CC
authors.lastname: Schultz
authors.forename: Jürgen R
authors.initials: JR
authors.lastname: Reichenbach
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
authors.forename: Ralf G M
authors.initials: RG
authors.lastname: Schlösser
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult