title: Long-term simulation of human exposure to atmospheric perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) in the Osaka urban area, Japan.
abstract: A publicly available atmospheric transport model, the Weather Research and Forecasting Chemistry Model ( http://ruc.noaa.gov/wrf/WG11/ ), was used to simulate atmospheric perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) emitted from a point source in the Osaka urban area (also known as Keihanshin), Japan. The time period of the simulation was from 1983 to 2008. The modeled air concentrations were highly correlated (r = 0.91) with the observed air concentrations. Intake levels by inhalation of simulated air concentrations and through the gastrointestinal tract as estimated by the food duplicate method were input to a pharmacokinetic model of the human body to simulate serum concentrations of PFOA and PFO (PFO(A)). For validation of the atmospheric model, simulated values were compared with those observed in serum samples. The simulated values generally agreed with those observed in serum samples from residents of the Keihanshin area (r = 0.93). It was confirmed that the atmospheric model was generally capable of projecting features of atmospheric PFO(A) as well as serum concentrations of PFO(A) in this case. The results indicated a dominant contribution of the atmospheric component to serum PFO(A) in humans near the point source in the Keihanshin area. In 2008, that contribution was about 70%.
authors.affiliation: Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Tamon
authors.initials: T
authors.lastname: Niisoe
authors.forename: Kouji H
authors.initials: KH
authors.lastname: Harada
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Akio
authors.initials: A
authors.lastname: Koizumi
mesh_terms: D000393:Air Pollutants / Q000097:blood / Q000633:toxicity*; D002210:Caprylates / Q000097:blood / Q000633:toxicity*; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005466:Fluorocarbons / Q000097:blood / Q000633:toxicity*; D006801:Humans; D007564:Japan; D014504:Urban Health
chemical_list: D000393:Air Pollutants; D002210:Caprylates; D005466:Fluorocarbons; C023036:perfluorooctanoic acid