title: Palladium-catalyzed decarboxylative couplings of 2-(2-azaaryl)acetates with aryl halides and triflates.
abstract: Pd-catalyzed decarboxylative cross-couplings of 2-(2-azaaryl)acetates with aryl halides and triflates have been discovered. This reaction is potentially useful for the synthesis of some functionalized pyridines, quinolines, pyrazines, benzoxazoles, and benzothiazoles. Theoretical analysis shows that the nitrogen atom at the 2-position of the heteroaromatics directly coordinates to Pd(II) in the decarboxylation transition state.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Shang
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Song-Lin
authors.initials: SL
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000085:Acetates; D002264:Carboxylic Acids; D006219:Halogens; D010165:Palladium