title: Biologically active biotin derivatives of schweinfurthin F.
abstract: As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United States.
authors.forename: Natalie C
authors.initials: NC
authors.lastname: Ulrich
authors.forename: Craig H
authors.initials: CH
authors.lastname: Kuder
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Hohl
authors.forename: David F
authors.initials: DF
authors.lastname: Wiemer
mesh_terms: D001710:Biotin / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; C518723:schweinfurthin F; D001710:Biotin