[Optimization of molding technics of xiaochuang granules by central composite design-response surface methodology].
OBJECTIVE
The optimal molding technics of Xiaochuang granules was selected.


METHODS
The main influential factors of the molding technics included the mixed excipients' ratio, the quantity times of excipients and the ethanol concentration. The molding effect was evaluated with the yield of qualified granules and solubility. The optimal technics of Xiaochuang granules was selected by central composite design-response surface methodology.


RESULTS
The optimal molding technics were as follows: the quantity times of excipients was 2.0, the proportion between mixed excipents (dextrin: lactose) was 1:1, and the ethanol concentration was 65%.


CONCLUSIONS
The molding technics of Xiaochuang granules is reasonable, stable and reliable.
Chen
Wei-wei
WW
Guangxi Traditional Chinese Medical University, Nanning 530001, China. weiwei690413@eyou.com
Nong
Yu-mei
YM
Liang
Dan
D
Deng
Chao-cheng
CC
Luo
Bin
B
D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry*; D015233:Models, Statistical; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D000431:Ethanol