title: Is acute high-dose secondhand smoke exposure always harmful to microvascular function in healthy adults?
abstract: Prev Cardiol. Long-term exposure to secondhand smoke (SHS) is associated with impaired vascular function. The authors investigated the vascular and blood pressure (BP) reactions to acute SHS exposure. Twenty-five healthy nonsmoking adults underwent a 1-hour exposure to SHS (mean fine particulate matter < 2.5 μm level = 315 ± 116 μg/m(3) ). Microvascular endothelial-dependent vasodilatation (EDV) (EndoPAT, Itamar Medical, Caesarea, Israel) and aortic hemodynamics/compliance (SphygmoCor, AtCor Medical, West Ryde, Australia) were measured before and after the SHS exposure with BP measured every 15 minutes during and for a 24-hour period before and after the exposure. SHS exposure did not change EDV, aortic hemodynamics, arterial compliance, or 24-hour BP. However, diastolic BP significantly increased during the SHS exposure period by 3.4 ± 5.6 mm Hg. Our brief SHS exposure did not impair microvascular endothelial function or arterial compliance in healthy nonsmoking adults, but brachial diastolic BP increased.
authors.affiliation: Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Bard
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Dvonch
authors.forename: Niko
authors.initials: N
authors.lastname: Kaciroti
authors.forename: Susan A
authors.initials: SA
authors.lastname: Lustig
authors.forename: Robert D
authors.initials: RD
authors.lastname: Brook
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D012307:Risk Factors; D016037:Single-Blind Method; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014664:Vasodilation; D055815:Young Adult
chemical_list: D014028:Tobacco Smoke Pollution