title: A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy.
abstract: A simple acid-resistant hydrophobic tag, which can be removed rapidly in a single-step procedure after overall peptide synthesis, has been developed to accomplish practical solution-phase synthesis of a 15-mer antagonistic peptide of TNF-α (A-TNF-α). Hydrophobically tagged peptides can be separated as precipitates at each step by addition of a polar organic solvent.
authors.affiliation: Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Gegen
authors.initials: G
authors.lastname: Tana
authors.forename: Shingo
authors.initials: S
authors.lastname: Kitada
authors.forename: Shuji
authors.initials: S
authors.lastname: Fujita
authors.forename: Yohei
authors.initials: Y
authors.lastname: Okada
authors.forename: Shokaku
authors.initials: S
authors.lastname: Kim
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Chiba
mesh_terms: D000595:Amino Acid Sequence; D057927:Hydrophobic and Hydrophilic Interactions; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D010455:Peptides; D012996:Solutions; D014409:Tumor Necrosis Factor-alpha