title: Prolonged EEG depression in term and near-term infants with hypoxic ischemic encephalopathy and later development of West syndrome.
abstract: OBJECTIVE
  This study was performed to clarify the relationship between prolonged depression of electroencephalography (EEG) in term and near-term infants with hypoxic ischemic encephalopathy (HIE) and the later development of West syndrome (WS).
  
  
  METHODS
  We investigated 17 term and near-term infants with HIE. Inclusion criteria were as follows: ≥35 weeks of gestation, clinical signs of HIE, magnetic resonance imaging (MRI) lesions corresponding to HIE, assessment of outcome at >18 months of age, depression of EEG, and serial EEG examinations. The 17 infants were divided into the following two groups: Group A (n = 4) with prolonged EEG depression over 21 days of age, and group B (n = 13) with disappearance of EEG depression by 21 days of age.
  
  
  RESULTS
  WS developed in all four infants in group A, but in only one of 13 infants in group B. WS occurred significantly more frequently in group A than in group B. For the prediction of subsequent development of WS, prolonged EEG depression over 21 days of age showed sensitivity of 0.80 and specificity of 1.0. In both groups, abnormal irregular faster waves with or without EEG depression were seen in 11 infants between 2 and 28 days of age. They had no significant relationship with WS, but were significantly related to an adverse developmental outcome.
  
  
  CONCLUSIONS
  Prolonged depression of EEG over 21 days of age in term or near-term infants with HIE is a valuable predictor of the later development of WS.
authors.affiliation: Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi, Japan. kato-jes@umin.ac.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Kato
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
authors.forename: Fumio
authors.initials: F
authors.lastname: Hayakawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Seiji
authors.initials: S
authors.lastname: Hayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kubota
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukasawa
authors.forename: Motomasa
authors.initials: M
authors.lastname: Suzuki
authors.forename: Koichi
authors.initials: K
authors.lastname: Maruyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Oshiro
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hattori
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kidokoro
authors.forename: Jun
authors.initials: J
authors.lastname: Natsume
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D013036:Spasms, Infantile / Q000175:diagnosis* / Q000503:physiopathology