Genetic damage in chronic renal failure patients is associated with the glomerular filtration rate index.
Chronic renal failure (CRF) patients are considered to present genomic instability and, as a consequence, elevated levels of genetic damage. An open question is whether this damage is related to the stage of the pathology. To determine the background levels of genetic damage, a large population of 258 Caucasian adults (201 CRF patients and 57 controls) was analysed using the micronucleus (MN) assay. The frequency of MN in CRF patients was significantly higher than in controls and correlated with the progression of the disease, according to the glomerular filtration rate. In addition, a significant association was observed between genetic damage and serum creatinine levels. Genetic damage, measured as frequency of MN, increases when renal function decreases. The fact that an increased level of MN is already observed in patients' Stage 2 seems to indicate a genetic predisposition on these patients. Nevertheless, part of the observed damage can be attributed to the uraemic state itself.
Sandoval
Silvia Berenice
SB
Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Edifici Cn, Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.
Stoyanova
Elitsa
E
Coll
Elisabet
E
Pastor
Susana
S
Reyes
Joselyn
J
Andrés
Enrique
E
Ballarin
José
J
Xamena
Noel
N
Marcos
Ricard
R
D000368:Aged; D016022:Case-Control Studies; D004249:DNA Damage / Q000502:physiology; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D007677:Kidney Function Tests; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis