Endometriosis and estroprogestins: the chicken or the egg causality dilemma.
Dysmenorrhea as a reason to initiate estroprogestins is significantly more common in women with endometriosis than in women without the disease. This might explain the previously reported mild association between endometriosis and past use of oral contraceptives.
Somigliana
Edgardo
E
Department of Obstetrics, Gynecology, and Neonatology, Fondazione Cà Granda, Milan, Italy. dadosomigliana@yahoo.it
Vercellini
Paolo
P
Vigano
Paola
P
Abbiati
Annalisa
A
Benaglia
Laura
L
Fedele
Luigi
L
D000328:Adult; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000453:epidemiology; D004715:Endometriosis / Q000188:drug therapy* / Q000453:epidemiology; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D009652:Norpregnenes / Q000008:administration & dosage* / Q000009:adverse effects; D012307:Risk Factors
D003276:Contraceptives, Oral; D004338:Drug Combinations; D009652:Norpregnenes; C494367:estroprogestin; D004997:Ethinyl Estradiol