Highly regioselective ruthenium-catalyzed allylic alkylations of chelated enolates.
Ru-catalyzed allylic alkylations are a highly interesting alternative to Pd-catalyzed reactions. Ru complexes show a high tendency for regioretention, especially for branched and (Z)-configured substrates, and they do not undergo isomerization of the allyl intermediates formed. Therefore, (Z)-substrates conserve their olefin geometry, and a perfect chirality transfer is observed with optically active substrates.
Bayer
Anton
A
Universität des Saarlandes, Institut für Organische Chemie, Im Stadtwald, Geb. 23.2, D-66123 Saarbrücken, Germany.
Kazmaier
Uli
U