title: [Uterine leiomyoma].
abstract: Uterine fibroids, benign tumors of the human uterus, are the most common indication for hysterectomy. They are clinically apparent in 20-25% of women and cause significant complaints, like prolonged and heavy menstruation, pelvic pressure or pain, sometimes reproductive dysfunction. Though surgery has been the mainstay of fibroid treatment, various minimally invasive procedures have been developed in addition to hysterectomy and abdominal myomectomy. Formation of new leiomyomas after these conservative therapies remains a substantial problem. Also drug-therapy methods are available, but the possible side-effects limit their long-term use. Authors attempt to give an overview of this common gynecological disease, yielding a new insight into the basic biology and genetics of fibroids, with the hope of new and effective methods of therapy in the future.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross utca 27. 1088.
authors.forename: Eva
authors.initials: E
authors.lastname: Csatlós
authors.forename: János
authors.initials: J
authors.lastname: Rigó
authors.forename: István
authors.initials: I
authors.lastname: Szabó
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Nagy
authors.forename: József Gábor
authors.initials: JG
authors.lastname: Joó
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004963:Estrenes / Q000627:therapeutic use; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D010535:Laparoscopy; D007889:Leiomyoma / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D015735:Mifepristone / Q000627:therapeutic use; D010091:Oximes / Q000627:therapeutic use; D014464:Ultrasonic Therapy; D055988:Uterine Artery; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D004963:Estrenes; D006727:Hormone Antagonists; D010091:Oximes; D015735:Mifepristone; C488516:asoprisnil