Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish.
Demographic aging gives rise to a growing population with age-associated behavioral and cognitive deficits that may be associated at least partially to the increasing prevalence of neurodegenerative disorders, such as Alzheimer's disease (AD). In this disease, it has been observed a decrease in the cholinergic system, which is crucial to memory formation. Scopolamine-induced amnesic effect, through the disruption of the cholinergic neurotransmission, is one of the approaches used to investigate the mechanisms involved in cognitive impairment observed in AD. The aim of our study was to investigate the potential protective role of quercetin and rutin against scopolamine-induced inhibitory avoidance memory deficits in zebrafish. Scopolamine (200 μM dissolved in the tank water for 1h) given pre-training hindered memory formation while both quercetin and rutin pretreatments (50mg/kg, single injection, i.p.) prevented the scopolamine-induced amnesia. None of the compounds affected zebrafish general locomotor activity. Together, these results contribute to the increase of the knowledge about plant compounds applicability as medicines to prevent and treat neurodegenerative diseases, like Alzheimer's disease.
Richetti
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SK
Laboratório de Neuroquímica e Psicofarmacologia, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619-900 Porto Alegre, RS, Brazil.
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Capiotti
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D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001362:Avoidance Learning / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D009043:Motor Activity / Q000187:drug effects; D011794:Quercetin / Q000627:therapeutic use*; D012431:Rutin / Q000627:therapeutic use*; D012601:Scopolamine / Q000633:toxicity*; D015027:Zebrafish
D000975:Antioxidants; D012431:Rutin; D011794:Quercetin; D012601:Scopolamine