Behavior of coagulation factors and normal inhibitors of coagulation during the acute phase of myocardial infarction.
Acute coronary syndromes are characterized by increased endothelial activation. The aim of this study was to investigate the behavior of coagulation factors V, VII, VIII and normal inhibitors antithrombin III and protein C during the acute phase of myocardial infarction. Thirty-six patients (27 men, nine women) and 35 normal individuals were studied during the acute phase of myocardial infarction, in the first 24 h. A group of 35 normal individuals was used as a control group. Blood samples were taken within the first 24 h of the hospital admission. The plasma levels of the coagulation factors were measured by the clot formation method, whereas the normal inhibitors were measured by ELISA. In the acute phase of myocardial infarction significant changes occur in coagulant and fibrinolytic factors. A decrease in plasma levels of factor V, antithrombin III and protein C was found in patients with acute myocardial infarction, compared to control group, whereas an increase in plasma levels of factor VII were observed. This study concludes that acute myocardial infarction causes consumption of fibrinolytic factors, whereas the coagulant factors seem to increase when being activated.
Moyssakis
Ioannis
I
Department of Cardiology, University of Athens, Laikon Hospital, Athens, Greece.
Vlahodimitris
Ioannis E
IE
Kanakis
Meletios A
MA
Kapsimali
Violetta
V
Tsoucala
Catherine
C
Vaiopoulos
George A
GA
D000208:Acute Disease; D000990:Antithrombin III / Q000032:analysis; D000991:Antithrombins / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis*; D016022:Case-Control Studies; D005165:Factor V / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011486:Protein C / Q000032:analysis
D000991:Antithrombins; D001779:Blood Coagulation Factors; D011486:Protein C; D000990:Antithrombin III; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII