Kinin receptor antagonists as potential neuroprotective agents in central nervous system injury.
Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.
Thornton
Emma
E
Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, South Australia, Australia. Emma.Thornton@adelaide.edu.au
Ziebell
Jenna M
JM
Leonard
Anna V
AV
Vink
Robert
R
D065168:Bradykinin Receptor Antagonists; D002490:Central Nervous System / Q000293:injuries / Q000473:pathology; D004487:Edema / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D064729:Neurokinin-1 Receptor Antagonists; D018696:Neuroprotective Agents; D020521:Stroke / Q000188:drug therapy / Q000473:pathology
D065168:Bradykinin Receptor Antagonists; D064729:Neurokinin-1 Receptor Antagonists; D018696:Neuroprotective Agents