title: Effectiveness of ketorolac tromethamine in prevention of severe retinopathy of prematurity.
abstract: OBJECTIVE
  This study assessed the effectiveness of the use of ketorolac tromethamine to reduce retinopathy of prematurity (ROP) incidence and its progression to more severe forms.
  
  
  METHODS
  Forty-seven preterm newborn infants with a birth weight (BW) of 1,000 grams or less and/or a gestational age (GA) of 29 weeks or less were enrolled in the study when avascular retina zone I or ROP any stage were diagnosed at screening. Studied infants were randomized to receive ketorolac tromethamine ophthalmic solution in one eye and a drop of placebo in the other eye, until ROP requiring treatment or full retinal vascularization was diagnosed.
  
  
  RESULTS
  Only 2 newborn infants did not develop ROP. Among 45 newborn infants who developed ROP, 6 showed different ROP staging between the two eyes, 4 of which had a better outcome in the eye receiving ketorolac tromethamine. The differences between ROP stagings were not significant even when analyzed by GA and BW subgroups. No significant treatment-related side effects occurred.
  
  
  CONCLUSIONS
  This report suggests that ketorolac tromethamine ophthalmic solution cannot reduce the risk of developing severe ROP in preterm infants.
authors.affiliation: Department of Pediatrics, Catholic University Sacred Heart, 00168 Rome, Italy. carmengiannantonio@libero.it
authors.forename: Carmen
authors.initials: C
authors.lastname: Giannantonio
authors.forename: Patrizia
authors.initials: P
authors.lastname: Papacci
authors.forename: Velia
authors.initials: V
authors.lastname: Purcaro
authors.forename: Francesco
authors.initials: F
authors.lastname: Cota
authors.forename: Mikael Ghennet
authors.initials: MG
authors.lastname: Tesfagabir
authors.forename: Fernando
authors.initials: F
authors.lastname: Molle
authors.forename: Domenico
authors.initials: D
authors.lastname: Lepore
authors.forename: Antonio
authors.initials: A
authors.lastname: Baldascino
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
mesh_terms: D001724:Birth Weight; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D020911:Ketorolac Tromethamine; D012178:Retinopathy of Prematurity / Q000175:diagnosis; D012307:Risk Factors
chemical_list: D020911:Ketorolac Tromethamine