title: Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent.
abstract: In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4 ± 2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706, Republic of Korea.
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Tae Sup
authors.initials: TS
authors.lastname: Lee
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Kang
authors.forename: Rita
authors.initials: R
authors.lastname: Song
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
mesh_terms: D000818:Animals; D005260:Female; D007457:Iodine Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D045663:Quantum Dots; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013388:Succinimides / Q000737:chemistry*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013388:Succinimides; C022581:Bolton-Hunter reagent