Targeting breast cancer stem cells: fishing season open!
Studies describing the tumor as a hierarchically organized cell population have changed the classical oncogenesis view and propose new therapeutic strategies. Cancer stem cells (CSCs) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cancer cure. A large research effort is now aiming to develop drugs targeting CSCs, based either on a priori understanding of key pathways regulating CSC biology or on high-throughput screening to identify novel targets and compounds.
Ginestier
Christophe
C
Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR Inserm/Institut Paoli-Calmettes, France. christophe.ginestier@inserm.fr
Charafe-Jauffret
Emmanuelle
E
Birnbaum
Daniel
D
D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051927:CD24 Antigen / Q000032:analysis; D015820:Cadherins / Q000037:antagonists & inhibitors; D045744:Cell Line, Tumor; D055808:Drug Discovery; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D051927:CD24 Antigen; D015820:Cadherins; D018960:Hyaluronan Receptors; D016328:NF-kappa B