Entropically modified spiking ability and periodicity in clustered channels.
It has been shown that, in models of excitable clusters of voltage-gated sodium channels, the spontaneous rate of action potential and signal encoding ability exhibit multiple peaks at different cluster sizes due to an entropy effect in small system. In this paper, we show that similar results can be found in excitable cluster of ligand-gated calcium channels. Furthermore, we demonstrate that the periodicity of spontaneous Ca2+ spikes elicited by the cluster reveals multiple maxima at small discrete cluster sizes.
Shuai
Jianwei
J
Department of Physics and Institute of Theoretical Physics and Astrophysics, Xiamen University, Xiamen 361005, China. jianweishuai@xmu.edu.cn
Sheng
Rong
R
Jung
Peter
P
D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D001703:Biophysics / Q000379:methods*; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism; D015220:Calcium Channels / Q000737:chemistry; D020013:Calcium Signaling; D016000:Cluster Analysis; D019277:Entropy; D006801:Humans; D008024:Ligands; D008962:Models, Theoretical; D015222:Sodium Channels / Q000737:chemistry*; D013269:Stochastic Processes; D013997:Time Factors
D015220:Calcium Channels; D008024:Ligands; D015222:Sodium Channels; D002118:Calcium