title: Impact of delayed graft function on renal function and graft survival in deceased kidney transplantation.
abstract: OBJECTIVE
  To define the risk factors for delayed graft function and study the impact of such delays on renal function and long-term allograft survival in renal transplant recipients.
  
  
  METHODS
  Single-centre retrospective study.
  
  
  METHODS
  Regional hospital, Hong Kong.
  
  
  METHODS
  Records of 118 Chinese renal transplant recipients from 1 July 1997 to 31 July 2005 were reviewed, and categorised into delayed and immediate graft function groups.
  
  
  RESULTS
  Delayed graft function was observed in about 19% of patients, for which cold ischaemic time was an important independent predictor. For each additional hour of cold ischaemic time, the odds ratio increased for delayed function by 0.002 (95% confidence interval, 0.001-0.003; P=0.03). Multivariate analysis revealed that neither cold ischaemic time nor delayed graft function was associated with acute rejection. On the other hand, at 1 year both delayed graft function (odds ratio=18.5; 95% confidence interval, 2.6-130.5; P=0.003) and donor age (1.2; 1.1-1.3; P=0.003) were related to a glomerular filtration rate of less than 30 mL/min. When renal function between patients with and without delayed graft function during the first 3 years was compared, it was significantly better in those without delayed graft function. However, there was no significant difference in death-censored graft survival between delayed graft function and immediate graft function groups.
  
  
  CONCLUSIONS
  Delayed graft function has a significant adverse effect on graft function at 1 year. Limiting cold ischaemic time is important as it is an independent predictor of delayed graft function.
authors.affiliation: Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Hong Kong. simoncycheung@gmail.com
authors.forename: C Y
authors.initials: CY
authors.lastname: Cheung
authors.forename: H W
authors.initials: HW
authors.lastname: Chan
authors.forename: Y H
authors.initials: YH
authors.lastname: Chan
authors.forename: K F
authors.initials: KF
authors.lastname: Chau
authors.forename: C S
authors.initials: CS
authors.lastname: Li
mesh_terms: D000328:Adult; D050377:Cold Ischemia / Q000379:methods*; D051799:Delayed Graft Function / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000209:etiology; D006085:Graft Survival; D006723:Hong Kong; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors