VEGF-independent angiogenic pathways induced by PDGF-C.
VEGF is believed to be a master regulator in both developmental and pathological angiogenesis. The role of PDGF-C in angiogenesis, however, is only at the beginning of being revealed. We and others have shown that PDGF-C is a critical player in pathological angiogenesis because of its pleiotropic effects on multiple cellular targets. The angiogenic pathways induced by PDGF-C are, to a large extent, VEGF-independent. These pathways may include, but not limited to, the direct effect of PDGF-C on vascular cells, the effect of PDGF-C on tissue stroma fibroblasts, and its effect on macrophages. Taken together, the pleiotropic, versatile and VEGF-independent angiogenic nature of PDGF-C has placed it among the most important target genes for antiangiogenic therapy.
Li
Xuri
X
National Eye Institute, NIH, Rockville, MD 20852, USA. lixur@nei.nih.gov
Kumar
Anil
A
Zhang
Fan
F
Lee
Chunsik
C
Li
Yang
Y
Tang
Zhongshu
Z
Arjuna
Pachiappan
P
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D016207:Cytokines; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; C411423:platelet-derived growth factor C; D020782:Matrix Metalloproteinases