[Effects of ginkgolide on hemodynamics in myocardial ischemic dogs].
OBJECTIVE
To investigate the effects of Ginkgolide on hemodynamics and myocardial oxygen metabolism in acute myocardial ischemic dogs.


METHODS
Acute myocardial ischemic model dogs were established by ligating left anterior descending coronary artery (LAD). Some hemodynamic parameters and cardiac oxygen consumption were observed after Ginkgolide were given to dogs through the duodenum.


RESULTS
Ginkgolide could increase LVSP, + dp/dt(max), LVWI, SW, CO and CBF, decrease TPVR, CVR, MVO2 and MOUR of Acute myocardial ischemic model dogs at different time points after ligation of LAD.


CONCLUSIONS
Ginkgolide can improve the hemodynamic conditions and oxygen metabolism of myocardial ischemic dogs.
Yin
Yan-yan
YY
Department of Pharmacology, Anhui Medical University, Hefei 230032, China. yinyanyan5678@126.com
Min
Xiao-fen
XF
Li
Wei-zu
WZ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides / Q000008:administration & dosage / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010101:Oxygen Consumption / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D046934:Ginkgolides