Chemokine receptor 5 △32 allele in patients with severe pandemic (H1N1) 2009.
Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.
Keynan
Yoav
Y
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. keynany@yahoo.com
Juno
Jennifer
J
Meyers
Adrienne
A
Ball
T Blake
TB
Kumar
Anand
A
Rubinstein
Ethan
E
Fowke
Keith R
KR
D000328:Adult; D000483:Alleles; D002170:Canada / Q000453:epidemiology; D016638:Critical Illness; D004196:Disease Outbreaks; D005260:Female; D006579:Heterozygote; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000472:pathogenicity*; D007251:Influenza, Human / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology* / Q000821:virology; D008297:Male; D058873:Pandemics; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion; D012720:Severity of Illness Index
D019713:Receptors, CCR5