Genetics of heart failure and sudden death.
Since the sentinel discovery of long QT syndrome as a channelopathy in 1995, many significant strides have been made related to exposing the pathogenic mechanisms underlying sudden cardiac death. However, elucidating the most influential genetic and environmental determinants that underlie the variable penetrance and expressivity of the primary syndrome-associated mutation remains a daunting task.
Vatta
Matteo
M
Department of Pediatrics Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA. mvatta@bcm.edu
Ackerman
Michael J
MJ
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000235:genetics / Q000628:therapy; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004562:Electrocardiography; D006333:Heart Failure / Q000235:genetics* / Q000628:therapy; D016027:Heart Transplantation; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D008133:Long QT Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
D000319:Adrenergic beta-Antagonists; D007473:Ion Channels