Substrate-induced covalent assembly of a chemzyme and crystallographic characterization of a chemzyme-substrate complex.
A substrate induced covalent assembly of a highly organized chemzyme known to be effective in both catalytic asymmetric aziridination and aza Diels-Alder reactions is described and the information gained from which led to an efficient one-pot aziridination protocol. The crystal structures of two chemzyme-iminium complexes were elucidated by X-ray diffraction analysis that provides critical insights into the binding of the substrates with the chemzyme.
Hu
Gang
G
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Gupta
Anil K
AK
Huang
Rui H
RH
Mukherjee
Munmun
M
Wulff
William D
WD
D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013379:Substrate Specificity
D004798:Enzymes