title: Dolabranes from the Chinese Mangrove, Ceriops tagal.
abstract: Six new dolabranes, named tagalsins P-U (1-6), were isolated from stems and twigs of a Chinese mangrove, Ceriops tagal, along with seven known dolabranes, an abietane, and a pimarane. The structures of these compounds were established on the basis of spectroscopic data or comparison with data in the literature. The relative configurations of tagalsins P and Q (1, 2), two new 15,16-dinor-dolabranes, were confirmed by means of single-crystal X-ray diffraction analysis. This is the first report of 16-nordolabranes and 15,16-dinordolabranes from plants of the Ceriops genus. Tagalsins Q (2), R (3), and U (6) showed moderate antifeedant activity against the third-instar larvae of Brontispa longissima at a concentration of 1 mg/mL. However, none of the new dolabranes exhibited significant activity against human cancer cell lines.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Hu
authors.forename: Min-Yi
authors.initials: MY
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xiao
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001517:Coleoptera / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects; D006801:Humans; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D043982:Rhizophoraceae / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C000605953:tagalsin Q; C000605954:tagalsin S