title: Systems-level feedback in cell-cycle control.
abstract: Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)-CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations are always well-conserved. The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism).
authors.affiliation: Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. bela.novak@bioch.ox.ac.uk
authors.forename: Béla
authors.initials: B
authors.lastname: Novák
authors.forename: P K
authors.initials: PK
authors.lastname: Vinod
authors.forename: Paula
authors.initials: P
authors.lastname: Freire
authors.forename: Orsolya
authors.initials: O
authors.lastname: Kapuy
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans
chemical_list: D018797:Cell Cycle Proteins; D019926:Cyclin B; D016203:CDC2 Protein Kinase