Genetic variation in insulin/IGF-1 signaling pathways and longevity.
The insulin/IGF-1 pathway has been shown to affect lifespan and rate of aging in a variety of animals including worms, flies and mice. Genetic variation in this pathway may also affect human longevity. We review the evidence for the effect of this pathway on longevity with a focus on the genetic studies in humans to date. One gene, FOXO3A, a transcriptional factor homologous to daf-16, has been repeatedly associated with increased lifespan in several studies in different ethnic populations.
Ziv
Elad
E
Department of Medicine, Institute for Human Genetics, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 94143-3116, United States. elad.ziv@ucsf.edu
Hu
Donglei
D
D000375:Aging / Q000235:genetics*; D000818:Animals; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D008136:Longevity / Q000235:genetics*; D051379:Mice; D020641:Polymorphism, Single Nucleotide; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D007328:Insulin; D014157:Transcription Factors; D007334:Insulin-Like Growth Factor I