title: Effects of nondependent lung ventilation with continuous positive-pressure ventilation and high-frequency positive-pressure ventilation on right-ventricular function during 1-lung ventilation.
abstract: Background. The application of volume-controlled high frequency positive pressure ventilation (HFPPV) to the nondependent lung (NL) may have comparable effects to continuous positive airway pressure (CPAP) on the right ventricular (RV) function, oxygenation, and surgical conditions during one lung ventilation (OLV) for thoracotomy. Methods. After local ethics committee approval and informed consent, 75 patients scheduled for elective thoracotomy using OLV were randomly allocated to receive nondependent lung either CPAP 2 (CPAP2; n=25) or 5 (CPAP5; n=25) cm H2O pressure setting of the device or HFPPV using VT 3 mL-1, I: E ratio <0.3 and R.R 60/min (HFPPV; n=25), followed 15 min of OLV. Intraoperative changes in RV ejection fraction (REF), end-diastolic volume (RVEDVI) and stroke work (RVSWI), stroke volume (SVI), oxygen delivery (DO2), and uptake (VO2) indices and shunt fraction (Qs: Qt) were recorded without any surgical manipulation of the lung. Results. The application of NL-HFPPV resulted in improved REF by 33%, SVI and DO2 (P < 0.01) and reduced RVEDVI, RVSWI, PVRI, oxygen uptake, and shunt fraction by 24.8% (P < 0.01) than in the NL-CPAP groups. Conclusion. We concluded that the use of NL-HFPPV is a feasible option and offers improved RV function and oxygenation during OLV for open thoracotomy.
authors.affiliation: University of Dammam, Al Khubar, Saudi Arabia. mohamedrefaateltahan@yahoo.com
authors.forename: Mohamed R
authors.initials: MR
authors.lastname: El Tahan
authors.forename: Yasser
authors.initials: Y
authors.lastname: El Ghoneimy
authors.forename: Mohamed
authors.initials: M
authors.lastname: Regal
authors.forename: Afrah
authors.initials: A
authors.lastname: Deria
authors.forename: Mona
authors.initials: M
authors.lastname: Al Ahmadey
authors.forename: Hatem
authors.initials: H
authors.lastname: El Emam
mesh_terms: D000293:Adolescent; D000328:Adult; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006612:High-Frequency Ventilation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D012121:Respiration, Artificial / Q000379:methods; D013318:Stroke Volume; D013908:Thoracotomy / Q000379:methods*; D016278:Ventricular Function, Right; D055815:Young Adult
chemical_list: D010100:Oxygen