title: A novel solid-angle tomosynthesis (SAT) scanning scheme.
abstract: OBJECTIVE
  Digital tomosynthesis (DTS) recently gained extensive research interests in both diagnostic and radiation therapy fields. Conventional DTS images are generated by scanning an x-ray source and flat-panel detector pair on opposite sides of an object, with the scanning trajectory on a one-dimensional curve. A novel tomosynthesis method named solid-angle tomosynthesis (SAT) is proposed, where the x-ray source scans on an arbitrary shaped two-dimensional surface.
  
  
  METHODS
  An iterative algorithm in the form of total variation regulated expectation maximization is developed for SAT image reconstruction. The feasibility and effectiveness of SAT is corroborated by computer simulation studies using three-dimensional (3D) numerical phantoms including a 3D Shepp-Logan phantom and a volumetric CT image set of a human breast.
  
  
  RESULTS
  SAT is able to cover more space in Fourier domain more uniformly than conventional DTS. Greater coverage and more isotropy in the frequency domain translate to fewer artifacts and more accurately restored features in the in-plane reconstruction.
  
  
  CONCLUSIONS
  Comparing with conventional DTS, SAT allows cone-shaped x-ray beams to project from more solid angles, thus provides more coverage in the spatial-frequency domain, resulting in better quality of reconstructed image.
authors.affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, 21201, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Cedric
authors.initials: C
authors.lastname: Yu
mesh_terms: D000465:Algorithms; D021621:Imaging, Three-Dimensional / Q000379:methods*; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*