title: CDMS (Clinical Data Mining Software): a cytokinome data mining system for a predictive medicine of chronic inflammatory diseases.
abstract: The cytokines, main players of the chronic inflammation progression leading to serious diseases such as diabetes or cancer, represent a target for better clinical prognosis and innovative therapeutic strategies. To investigate the immunopathogenetic progression of these diseases, the evaluation of serum cytokines profiles made of many different proteins is much more informative than single protein measurements. We developed a Clinical Data Mining Software to collect cytokine profiles evaluated on healthy subjects and patients by multiplex immunoassays also annotated with their clinical and laboratory data, to compare patient profiles by statistical tools and to evaluate their disease progression.
authors.affiliation: Centro Ricerche Oncologiche Mercogliano, 'Fiorentino Lo Vuolo', via Ammiraglio Bianco, 83013 Mercogliano, Avellino, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Evangelista
authors.forename: G
authors.initials: G
authors.lastname: Colonna
authors.forename: M
authors.initials: M
authors.lastname: Miele
authors.forename: F
authors.initials: F
authors.lastname: Cutugno
authors.forename: G
authors.initials: G
authors.lastname: Castello
authors.forename: S
authors.initials: S
authors.lastname: Desantis
authors.forename: S
authors.initials: S
authors.lastname: Costantini
mesh_terms: D000465:Algorithms; D002908:Chronic Disease; D019295:Computational Biology / Q000379:methods*; D016207:Cytokines / Q000097:blood*; D003627:Data Interpretation, Statistical; D057225:Data Mining / Q000379:methods*; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006801:Humans; D007118:Immunoassay; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis; D020407:Internet; D008297:Male; D012984:Software
chemical_list: D016207:Cytokines