title: Palladium-catalyzed amination of unprotected halo-7-azaindoles.
abstract: Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.
authors.affiliation: Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Jaclyn L
authors.initials: JL
authors.lastname: Henderson
authors.forename: Sarah M
authors.initials: SM
authors.lastname: McDermott
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000586:Amination; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: C023422:7-azaindole dimer; D007211:Indoles; D008024:Ligands; D010165:Palladium