Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics.
Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.
Schüring
Andreas N
AN
Department of Gynecology and Obstetrics, University Clinic of Münster, Münster, Germany. Andreas.Schuering@ukmuenster.de
Schulte
Nicole
N
Kelsch
Reinhard
R
Röpke
Albrecht
A
Kiesel
Ludwig
L
Götte
Martin
M
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology*; D001706:Biopsy; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D002469:Cell Separation; D004717:Endometrium / Q000166:cytology*; D005260:Female; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology