[Cytokines in bone diseases. Cytokines and myeloma bone disease].
Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. MM cells produce a variety of cytokines to stimulate bone resorption by enhancing osteoclast formation and suppress bone formation by inhibiting osteoblast differentiation, leading to bone destruction and rapid loss of bone. In these lesions, osteoclasts and bone marrow stromal cells/immature osteoblasts create a microenvironment suitable for myeloma cell growth and survival, thereby forming a vicious cycle between bone destruction and myeloma expansion.
Abe
Masahiro
M
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine.
D001854:Bone Marrow Cells / Q000473:pathology; D001862:Bone Resorption / Q000209:etiology; D002450:Cell Communication; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000502:physiology; D009101:Multiple Myeloma / Q000209:etiology* / Q000473:pathology*; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis; D053245:RANK Ligand / Q000502:physiology; D017154:Stromal Cells / Q000473:pathology
D016207:Cytokines; D019402:Macrophage Inflammatory Proteins; D053245:RANK Ligand