Thalidomide treatment attenuates chemotherapy-induced gonadal toxicity.
The aim of this study was to investigate gonadal-protective properties of thalidomide in a mouse model of chemotherapy-induced ovarian failure. Administration of thalidomide before alkylating chemotherapy preserved ovarian follicles and lead to the resumption of normal estrous cyclicity.
Ochalski
Melanie E
ME
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA. ochamm@upmc.edu
Shuttleworth
Jennifer J
JJ
Chu
Tianjiao
T
Orwig
Kyle E
KE
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002452:Cell Count; D019610:Cytoprotection / Q000187:drug effects; D004195:Disease Models, Animal; D015536:Down-Regulation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006066:Gonads / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D010053:Ovary / Q000187:drug effects* / Q000473:pathology; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D013792:Thalidomide / Q000008:administration & dosage / Q000627:therapeutic use*
D020533:Angiogenesis Inhibitors; D013792:Thalidomide