Gut microbiota and related diseases: clinical features.
Intestinal microbiota is essential for gut homeostasis. Specifically, the microorganisms inhabiting the gut lumen interact with the intestinal immune system, supply key nutrients for the major components of the gut wall, and modulate energy metabolism. Host-microbiome interactions can be either beneficial or deleterious, driving gastrointestinal lymphoid tissue activities and shaping gut wall structures. This overview briefly focuses on the potential role played by abnormalities in gut microbiota and relative responses of the gastrointestinal tract in the determination of important pathological conditions such as the irritable bowel syndrome, inflammatory bowel diseases and colorectal cancer.
Stanghellini
Vincenzo
V
Department of Clinical Medicine, St. Orsola-Malpighi Hospital, University of Bologna, Building No. 5, Via Massarenti, 9, 40138, Bologna, Italy. v.stanghellini@unibo.it
Barbara
Giovanni
G
Cremon
Cesare
C
Cogliandro
Rosanna
R
Antonucci
Alexandra
A
Gabusi
Veronica
V
Frisoni
Chiara
C
De Giorgio
Roberto
R
Grasso
Valentina
V
Serra
Mauro
M
Corinaldesi
Roberto
R
D003106:Colon / Q000187:drug effects / Q000382:microbiology*; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000382:microbiology; D003469:Culture; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000382:microbiology; D043183:Irritable Bowel Syndrome / Q000382:microbiology* / Q000473:pathology; D007558:Italy / Q000453:epidemiology; D054892:Metagenome; D019936:Probiotics; D012007:Rectum / Q000187:drug effects / Q000382:microbiology*; D012307:Risk Factors