A versatile and practical microwave-assisted synthesis of sterically hindered N-arylpiperazines.
A wide-ranging and practical synthesis of structurally diverse, sterically hindered N-arylpiperazines from 2,2'-(4-nitrophenylsulfonylazanediyl) bis(ethane-2,1-diyl) bis(4-nitrobenzenesulfonate) and substituted anilines has been achieved using microwave irradiation in acetonitrile followed by deprotection with PhSH.
Gao
Rong
R
Temple University School of Pharmacy, Department of Pharmaceutical Sciences, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA.
Canney
Daniel J
DJ
D000588:Amines / Q000737:chemistry; D008872:Microwaves; D009584:Nitrogen / Q000737:chemistry*; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry*
D000588:Amines; D010879:Piperazines; D009584:Nitrogen