Hemophagocytic syndrome in a patient with acute tubulointerstitial nephritis secondary to hepatitis A virus infection.
Hepatitis A virus (HAV) infection is generally a self-limited disease, but the infection in adults can be serious, to be often complicated by acute kidney injury (AKI) and rarely by virus-associated hemophagocytic syndrome (VAHS). Our patient, a 48-yr-old man, was diagnosed with HAV infection complicated by dialysis-dependent AKI. His kidney biopsy showed acute tubulointerstitial nephritis with massive infiltration of activated macrophages and T cells, and he progressively demonstrated features of VAHS. With hemodialysis and steroid treatment, he was successfully recovered.
Cho
Eunjung
E
Department of Internal Medicine, Korea University Medical College, Korea University Anam Hospital, Seoul, Korea.
Cha
Inhye
I
Yoon
Kichul
K
Yang
Ha Na
HN
Kim
Hye Won
HW
Kim
Myung-Gyu
MG
Jo
Sang-Kyung
SK
Cho
Won Yong
WY
Kim
Hyoung Kyu
HK
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy; D000914:Antibodies, Viral / Q000032:analysis; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral