title: Effect of dietary conjugated linoleic acid supplementation on early inflammatory responses during cutaneous wound healing.
abstract: Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.
authors.affiliation: Department of Food and Nutrition, Research Institute of Science for Human Life, Kyung Hee University, Dongdaemun-gu, Seoul 130-761, Republic of Korea.
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Park
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Valacchi
authors.forename: Yunsook
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000378:metabolism; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D005260:Female; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D044243:Linoleic Acids, Conjugated; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D051547:Heme Oxygenase-1; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D013482:Superoxide Dismutase