title: Detection of low-level PTFE contamination: An application of solid-state NMR to structure elucidation in the pharmaceutical industry.
abstract: We report a novel use of solid-state ¹⁹F nuclear magnetic resonance to detect and quantify polytetrafluoroethylene contamination from laboratory equipment, which due to low quantity (up to 1% w/w) and insolubility remained undetected by standard analytical techniques. Solid-state ¹⁹F NMR is shown to be highly sensitive to such fluoropolymers (detection limit 0.02% w/w), and is demonstrated as a useful analytical tool for structure elucidation of unknown solid materials.
authors.affiliation: Chemical Development, GlaxoSmithKline Plc, Gunnels Wood Road, Stevenage, Hertfordshire SG12NY, UK. tran.pham@gsk.com
authors.forename: Tran N
authors.initials: TN
authors.lastname: Pham
authors.forename: Caroline J
authors.initials: CJ
authors.lastname: Day
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Edwards
authors.forename: Helen R
authors.initials: HR
authors.lastname: Wood
authors.forename: Ian R
authors.initials: IR
authors.lastname: Lynch
authors.forename: Simon A
authors.initials: SA
authors.lastname: Watson
authors.forename: Anne-Sophie Z
authors.initials: AS
authors.lastname: Bretonnet
authors.forename: Frederick G
authors.initials: FG
authors.lastname: Vogt
mesh_terms: D004304:Dosage Forms; D004340:Drug Contamination / Q000517:prevention & control*; D057230:Limit of Detection; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D011138:Polytetrafluoroethylene / Q000032:analysis / Q000737:chemistry
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D011138:Polytetrafluoroethylene