title: Liver involvement associated with dengue infection in adults in Vietnam.
abstract: Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children. We describe the spectrum and evolution of disease manifestations among 644 adults with dengue who were prospectively recruited on admission to a major infectious disease hospital in southern Vietnam and compare them with a group of patients with similar illnesses not caused by dengue. Transaminase levels increased in virtually all dengue patients and correlated with other markers of disease severity. However, peak enzyme values usually occurred later than other complications. Clinically severe liver involvement was infrequent and idiosyncratic, but usually resulted in severe bleeding. Chronic co-infection with hepatitis B was associated with modestly but significantly increased levels of alanine aminotransferase, but did not otherwise impact the clinical picture.
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. trungdt@oucru.org
authors.forename: Dinh The
authors.initials: DT
authors.lastname: Trung
authors.forename: Le Thi Thu
authors.initials: le TT
authors.lastname: Thao
authors.forename: Tran Tinh
authors.initials: TT
authors.lastname: Hien
authors.forename: Nguyen The
authors.initials: NT
authors.lastname: Hung
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Vinh
authors.forename: Pham Tran Dieu
authors.initials: PT
authors.lastname: Hien
authors.forename: Nguyen Tran
authors.initials: NT
authors.lastname: Chinh
authors.forename: Cameron
authors.initials: C
authors.lastname: Simmons
authors.forename: Bridget
authors.initials: B
authors.lastname: Wills
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003715:Dengue / Q000150:complications* / Q000453:epidemiology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000209:etiology* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase