Evaluation by fluid/structure-interaction spinal-cord simulation of the effects of subarachnoid-space stenosis on an adjacent syrinx.
A finite-element numerical model was constructed of the spinal cord, pia mater, filum terminale, cerebrospinal fluid in the spinal subarachnoid space (SSS), and dura mater. The cord was hollowed out by a thoracic syrinx of length 140 mm, and the SSS included a stenosis of length 30 mm opposite this syrinx. The stenosis severity was varied from 0% to 90% by area. Pressure pulse excitation was applied to the model either at the cranial end of the SSS, simulating the effect of cranial arterial pulsation, or externally to the abdominal dura mater, simulating the effect of cough. A very short pulse was used to examine wave propagation; a pulse emulating cardiac systole was used to examine the effects of fluid displacement. Additionally, repetitive sinusoidal excitation was applied cranially. Bulk fluid flow past the stenosis gave rise to prominent longitudinal pressure dissociation ("suck") in the SSS adjacent to the syrinx. However, this did not proportionally increase the longitudinal motion of fluid in the syrinx. The inertia of the fluid in the SSS, together with the compliance of this space, gave a resonance capable of being excited constructively or destructively by cardiac or coughing impulses. The main effect of mild stenosis was to lower the frequency of this resonance; severe stenosis damped out to-and-fro motions after the end of the applied excitation. Syrinx fluid motion indicated the fluid momentum and thus the pressure developed when the fluid was stopped by the end of the syrinx; however, the tearing stress in the local cord material depended also on the instantaneous local SSS pressure and was therefore not well predicted by syrinx fluid motion. Stenosis was also shown to give rise to a one-way valve effect causing raised SSS pressure caudally and slight average cord displacement cranially. The investigation showed that previous qualitative predictions of the effects of suck neglected factors that reduced the extent of the resulting syrinx fluid motion and of the cord tearing stress, which ultimately determines whether the syrinx lengthens.
Bertram
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Biofluid Mechanics Laboratory, Faculty of Engineering, University of New South Wales, Sydney 2052, Australia.
D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D003198:Computer Simulation; D004388:Dura Mater / Q000503:physiopathology; D020342:Finite Element Analysis; D006801:Humans; D057446:Hydrodynamics; D008959:Models, Neurological; D010841:Pia Mater / Q000503:physiopathology; D013116:Spinal Cord / Q000503:physiopathology*; D013130:Spinal Stenosis / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D013346:Subarachnoid Space / Q000473:pathology / Q000503:physiopathology*; D013595:Syringomyelia / Q000134:cerebrospinal fluid / Q000503:physiopathology