title: Renal dysplasia in Beagle dogs: four cases.
abstract: Anomalies of renal development comprise abnormalities in the amount of renal tissue (agenesis and hypoplasia); anomalies of renal position, form, and orientation; and renal dysplasia. There are previous reports of canine renal dysplasia in different breeds but none in the Beagle breed. This is the first report of renal dysplasia in this breed of dog. Morphologic descriptions of the range of microscopic features observed in four cases of renal dysplasia from preclinical studies in laboratory Beagle dogs are presented (including persistent primitive mesenchyme, persistence of metanephric ducts, asynchronous differentiation of nephrons, and atypical tubular epithelium), along with a basis for the classification of the lesion.
authors.affiliation: Pfizer Ltd, IPC 330, Drug Safety Research & Development, Kent CT13 9NJ, UK. marc.bruder@novartis.com
authors.forename: Marc C
authors.initials: MC
authors.lastname: Bruder
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Shoieb
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Shirai
authors.forename: Germaine G
authors.initials: GG
authors.lastname: Boucher
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Brodie
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D005260:Female; D007668:Kidney / Q000002:abnormalities*; D007674:Kidney Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000235:genetics / Q000473:pathology / Q000662:veterinary; D008297:Male