[Connexin 43 expression in intraperitoneal free gastric cancer cells in patients with gastric cancer].
OBJECTIVE
To examine the association of connexin 43 (Cx43) in the intraperitoneal free gastric cancer cells and clinicopathological characteristics.


METHODS
Immunohistochemistry and immunofluorescence staining were used to detect connexin 43 in 75 paraffin-embedded gastric cancer tissues, matched paracancerous tissue, and intraperitoneal free gastric cancer cells.


RESULTS
The positive rates of Cx43 expression were 33.3% (25/75) in gastric cancer tissue specimens and 100% (75/75) in matched paracancerous tissue (P<0.01). The positive detection rate of free cancer cells in peritoneal lavage was 38.6% (29/75) and the positive rate of Cx43 in peritoneal free gastric cancer cells was 72.4% (21/29), which was significantly higher than that in gastric cancer tissue specimens (P<0.01). Significant association was observed of Cx43 expression of free gastric cancer cells with tumor infiltration and histological type (P<0.05).


CONCLUSIONS
Cx43 gene may be involved in the mechanism of peritoneal metastasis of gastric cancer.
Tang
Bo
B
Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
Yu
Pei-wu
PW
Peng
Zhi-hong
ZH
Yu
Ge
G
Qian
Feng
F
Zhao
Yong-liang
YL
Shi
Yan
Y
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018031:Connexin 43 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000556:secondary*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
D018031:Connexin 43