title: Expression of e-selectin in the skin of patients with atopic dermatitis: morphometric study.
abstract: Adhesion molecules may play an important role in the homing of T-cell subsets into allergen-exposed skin of atopic individuals. The aim of this study was to examine the expression of adhesion molecules in atopic dermatitis skin lesions. Biopsies were obtained from lesions in 30 adult patients with atopic dermatitis and 10 healthy adults as controls. Biopsy specimens were studied by immunohistochemistry for the expression of E-selectin in epidermis and dermis cells. Results showed significant changes in the epithelial cell expression of E-selectin, which were especially pronounced in vascular endothelium of the dermis of atopic dermatitis patients.
authors.affiliation: University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine, University of Zagreb, Šalata 4, Zagreb, Croatia. sandra.marinovic@zg.htnet.hr
authors.forename: Sandra
authors.initials: S
authors.lastname: Marinović Kulišić
authors.forename: Jasna
authors.initials: J
authors.lastname: Lipozenčić
authors.forename: Gordana
authors.initials: G
authors.lastname: Gregorović
authors.forename: Gordana
authors.initials: G
authors.lastname: Gregurek
authors.forename: Gordana
authors.initials: G
authors.lastname: Lacković
authors.forename: Gordana
authors.initials: G
authors.lastname: Jurić-Lekić
mesh_terms: D000328:Adult; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000378:metabolism* / Q000473:pathology; D020405:Dermis / Q000378:metabolism; D019040:E-Selectin / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012867:Skin / Q000378:metabolism* / Q000473:pathology
chemical_list: D019040:E-Selectin