title: [Severe extrathoracic sarcoidosis].
abstract: Sarcoidosis may affect functional outcome and sometimes may be a life-threatening condition. Functional outcome is particularly compromised by cutaneous, ocular, nasal, osteoarticular manifestations and some neurological expression. Central nervous system involvement and cardiac sarcoidosis could be life-threatening, as laryngeal and renal involvement. Diagnosis is sometimes very difficult to obtain. Several tissue biopsies are usually necessary to rule out all differential diagnosis. Extrathoracic manifestations of severe sarcoidosis require a corticosteroid therapy, initiated, if life-threatening at a daily dose of 1 mg/kg, usually associated with an other immunosuppressive drug (methotrexate, cyclophosphamide, anti TNFα).
authors.affiliation: Service de médecine interne II, CHU Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France. catherine.chapelon@psl.aphp.fr
authors.forename: C
authors.initials: C
authors.lastname: Chapelon Abric
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy; D007818:Laryngeal Diseases / Q000175:diagnosis / Q000188:drug therapy; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy*; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents