Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies.
OBJECTIVE
The globus pallidus plays a critical role in movement regulation. Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and systemic administration of a neurotensin analog could produce antiparkinsonian effects. The present study aimed to investigate the effects of pallidal neurotensin on haloperidol-induced parkinsonian symptoms.


METHODS
Behavioral experiments and electrophysiological recordings were performed in the present study.


RESULTS
Bilateral infusions of neurotensin into the globus pallidus reversed haloperidol-induced parkinsonian catalepsy in rats. Electrophysiological recordings showed that microinjection of neurotensin induced excitation of pallidal neurons in the presence of systemic haloperidol administration. The neurotensin type-1 receptor antagonist SR48692 blocked both the behavioral and the electrophysiological effects induced by neurotensin.


CONCLUSIONS
Activation of pallidal neurotensin receptors may be involved in neurotensin-induced antiparkinsonian effects.
Xue
Yan
Y
Department of Physiology, Qingdao University, Qingdao 266071, China.
Chen
Lei
L
D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D006220:Haloperidol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D009496:Neurotensin / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
D014150:Antipsychotic Agents; D009496:Neurotensin; D006220:Haloperidol