TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26.
Behcet's disease (BD) is a chronic inflammatory autoimmune disease and strongly associated with human leukocyte antigen (HLA)-B∗51 and -A∗26. We examined whether other genetic factors may exist in HLA region by 135 single nucleotide polymorphisms (SNPs) in 384 pairs of Japanese BD patients and controls. Multiple logistic regression analysis identified two novel susceptibility SNPs: rs9261365 near a ring finger protein (RNF) 39 and rs2074474 on exon 9 of tripartite motif-containing (TRIM) 39 independently of HLA-B∗51 and -A∗26 alleles. Our findings suggest that RNF39 and TRIM39 are involved in the etiology of BD.
Kurata
Riho
R
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1143, Japan.
Nakaoka
Hirofumi
H
Tajima
Atsushi
A
Hosomichi
Kazuyoshi
K
Shiina
Takashi
T
Meguro
Akira
A
Mizuki
Nobuhisa
N
Ohono
Shigeaki
S
Inoue
Ituro
I
Inoko
Hidetoshi
H
D001528:Behcet Syndrome / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D059949:HLA-B51 Antigen; D006239:Haplotypes; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics*; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D044767:Ubiquitin-Protein Ligases
D002352:Carrier Proteins; D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D017874:Immediate-Early Proteins; C444639:RNF39 protein, human; C414583:TRIM39 protein, human; D044767:Ubiquitin-Protein Ligases