Metabolic dysfunction in the pathogenesis of pulmonary hypertension.
Pulmonary artery hypertension is characterized by proliferation in the resistance vessels. A recent study in Science Translational Medicine (Sutendra et al., 2010) found that increased fatty acid oxidation and a shift in the glycolysis/glucose oxidation ratio may be central to the pathogenesis of this process, suggesting that these abnormalities comprise novel treatment targets.
Rubin
Lewis J
LJ
University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ljrubin@ucsd.edu.