title: Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.
abstract: Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio [OR] = 1.72, 95% confidence interval [CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio [HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese.
authors.affiliation: Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Longfei
authors.initials: L
authors.lastname: Jia
authors.forename: Xiumei
authors.initials: X
authors.lastname: Zuo
authors.forename: Yongbiao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Aihong
authors.initials: A
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Haiqing
authors.initials: H
authors.lastname: Song
authors.forename: Cuibai
authors.initials: C
authors.lastname: Wei
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
authors.forename: Muni
authors.initials: M
authors.lastname: Tang
authors.forename: Duen-Mei
authors.initials: DM
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007339:Insulysin / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D007339:Insulysin