title: Driving biochemical discovery with quantitative proteomics.
abstract: Proteomic analysis of biological samples plays an increasing role in modern research. Although the application of proteomics technologies varies across many disciplines, proteomics largely is a tool for discovery that then leads to novel hypotheses. In recent years, new methods and technologies have been developed and applied in many areas of proteomics, and there is a strong push towards using proteomics in a quantitative manner. Indeed, mass spectrometry-based, quantitative proteomics approaches have been applied to great success in a variety of biochemical studies. In particular, the use of quantitative proteomics provides new insights into protein complexes and post-translational modifications and leads to the generation of novel insights into these important biochemical systems.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, 1000 E. 50(th) St., MO 64110, USA. mpw@stowers.org
authors.forename: Michael P
authors.initials: MP
authors.lastname: Washburn
mesh_terms: D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods*