Prevalence of human papilloma virus infections and cervical cytological abnormalities among Korean women with systemic lupus erythematosus.
We performed a multicenter cross-sectional study of 134 sexually active systemic lupus erythematosus (SLE) patients to investigate the prevalence of and risk factors for high risk human papilloma virus (HPV) infection and cervical cytological abnormalities among Korean women with SLE. In this multicenter cross-sectional study, HPV testing and routine cervical cytologic examination was performed. HPV was typed using a hybrid method or the polymerase chain reaction. Data on 4,595 healthy women were used for comparison. SLE patients had greater prevalence of high-risk HPV infection (24.6% vs. 7.9%, P<0.001, odds ratio 3.8, 95% confidence interval 2.5-5.7) and of abnormal cervical cytology (16.4 vs. 2.8%, P<0.001, OR 4.4, 95% CI 2.5-7.8) compared with controls. SLE itself was identified as independent risk factors for high risk HPV infection among Korean women (OR 3.8, 95% CI 2.5-5.7) along with ≥2 sexual partners (OR 8.5, 95% CI 1.2-61.6), and Pap smear abnormalities (OR 97.3, 95% CI 6.5-1,456.7). High-risk HPV infection and cervical cytological abnormalities were more common among Korean women with SLE than controls. SLE itself may be a risk factor for HPV infection among Korean women, suggesting the importance of close monitoring of HPV infections and abnormal Pap smears in SLE patients.
Lee
You-Hyun
YH
Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Choe
Jung-Yoon
JY
Park
Sung-Hoon
SH
Park
Yong-Wook
YW
Lee
Shin-Seok
SS
Kang
Young-Mo
YM
Nam
Eon-Jeong
EJ
Park
Won
W
Kwon
Seong-Ryul
SR
Bae
Sang-Cheol
SC
Kim
Yun-Jung
YJ
Suh
Chang-Hee
CH
Kim
Hyoun-Ah
HA
Hur
Nam Wook
NW
Lee
Jisoo
J
D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D016017:Odds Ratio; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D056910:Republic of Korea; D012307:Risk Factors; D014626:Vaginal Smears; D014930:Women