title: Fitness effects of replichore imbalance in Salmonella enterica.
abstract: A fitness cost due to imbalanced replichores has been proposed to provoke chromosome rearrangements in Salmonella enterica serovars. To determine the impact of replichore imbalance on fitness, the relative fitness of isogenic Salmonella strains containing transposon-held duplications of various sizes and at various chromosomal locations was determined. Although duplication of certain genes influenced fitness, a replichore imbalance of up to 16° did not affect fitness.
authors.affiliation: Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, CA 92182-1010, USA.
authors.forename: T David
authors.initials: TD
authors.lastname: Matthews
authors.forename: Stanley
authors.initials: S
authors.lastname: Maloy
mesh_terms: D002876:Chromosomes, Bacterial; D004261:DNA Replication; D004251:DNA Transposable Elements; D020440:Gene Duplication; D015321:Gene Rearrangement; D016254:Mutagenesis, Insertional; D019779:Salmonella enterica / Q000235:genetics* / Q000254:growth & development*
chemical_list: D004251:DNA Transposable Elements