Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies.
Two modern synthetic technologies to perform 1,3-dipolar cycloaddition reactions were compared. This study puts in evidence the power of microwave-assisted and flow-based methodologies compared to the conventional one in terms of reaction time and yield, and demonstrates the potential of flow chemistry in terms of time, automation, and scaling up opportunities.
Castellano
Sabrina
S
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy.
Tamborini
Lucia
L
Viviano
Monica
M
Pinto
Andrea
A
Sbardella
Gianluca
G
Conti
Paola
P
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
D019086:Bridged Bicyclo Compounds, Heterocyclic; D007555:Isoxazoles; D009570:Nitriles; D011758:Pyrroles; C013231:pyrroline