Immunological aspects of epilepsy.
In recent years, the concept of an immunological background of some types of epilepsy has been gaining an increasing number of supporters. The following article is an attempt to review the most significant studies that explore irregularities in patients with intractable epilepsy, search for and identify the immunological causal factors of seizures and, finally, associate these factors with particular syndromes that manifest in refractory epilepsy. We also discuss the efficacy of immunomodulatory treatment in the recognized syndromes. Last, we focus on the immunological abnormalities found in patients undergoing antiepileptic therapy with classical antiepileptic drugs as well as changes in the immune system that could be provoked by an epileptic seizure itself.
Zarczuk
Radosław
R
Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Łukasik
Dariusz
D
Jedrych
Marian
M
Borowicz
Kinga K
KK
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004351:Drug Resistance; D004660:Encephalitis / Q000150:complications / Q000276:immunology; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology
D000927:Anticonvulsants; D007155:Immunologic Factors