title: Preparation of amino alcohols condensed with carbohydrates: Evaluation of cytotoxicity and inhibitory effect on NO production.
abstract: This work reports the preparation of several amino alcohols condensed with d-arabinose, d-glucose, and d-galactose derivatives. These compounds were evaluated in vitro for their cytotoxicity and ability to decrease nitric oxide production in J774A.1 cells. Arabinofuranoside derivatives 5a, 5b and 5c showed a significant inhibition of nitric oxide production (>80% at 5 μg/mL), while the galactopyranoside derivative 8d showed a notable nitric oxide inhibitory activity (126% at 0.5 μg/mL).
authors.forename: Taís A
authors.initials: TA
authors.lastname: Corrêa
authors.forename: Elaine F C
authors.initials: EF
authors.lastname: Reis
authors.forename: Lívia L
authors.initials: LL
authors.lastname: Alves
authors.forename: Caio C S
authors.initials: CC
authors.lastname: Alves
authors.forename: Sandra B R
authors.initials: SB
authors.lastname: Castro
authors.forename: Alyria T
authors.initials: AT
authors.lastname: Dias
authors.forename: Aline F
authors.initials: AF
authors.lastname: Taveira
authors.forename: Mireille
authors.initials: M
authors.lastname: Le Hyaric
authors.forename: Mara R C
authors.initials: MR
authors.lastname: Couri
authors.forename: Ana P
authors.initials: AP
authors.lastname: Ferreira
authors.forename: Mauro V
authors.initials: MV
authors.lastname: De Almeida
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D001089:Arabinose / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D005690:Galactose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D000605:Amino Alcohols; D002241:Carbohydrates; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D007371:Interferon-gamma; D001089:Arabinose; D005947:Glucose; D005690:Galactose