title: Applications and bioefficacy of the functional food supplement fermented papaya preparation.
abstract: Fermented papaya preparation (FPP) (a product of yeast fermentation of Carica papaya Linn) is a food supplement. Studies in chronic and degenerative disease conditions (such as thalassemia, cirrhosis, diabetes and aging) and performance sports show that FPP favorably modulates immunological, hematological, inflammatory, vascular and oxidative stress damage parameters. Neuroprotective potential evaluated in an Alzheimer's disease cell model showed that the toxicity of the β-amyloid can be significantly modulated by FPP. Oxidative stress trigger apoptotic pathways such as the c-jun N-terminal kinase (JNK) and p38-mitogen activated protein kinase (MAPK) are preferentially activated by pro-inflammatory cytokines and oxidative stress resulting in cell differentiation and apoptosis. FPP modulated the H₂O₂-induced ERK, Akt and p38 activation with the reduction of p38 phosphorylation induced by H₂O₂. FPP reduces the extent of the H₂O₂-induced DNA damage, an outcome corroborated by similar effects obtained in the benzo[a]pyrene treated cells. No genotoxic effect was observed in experiments with FPP exposed to HepG2 cells nor was FPP toxic to the PC12 cells. Oxidative stress-induced cell damage and inflammation are implicated in a variety of cancers, diabetes, arthritis, cardiovascular dysfunctions, neurodegenerative disorders (such as stroke, Alzheimer's disease, and Parkinson's disease), exercise physiology (including performance sports) and aging. These conditions could potentially benefit from functional nutraceutical/food supplements (as illustrated here with fermented papaya preparation) exhibiting anti-inflammatory, antioxidant, immunostimulatory (at the level of the mucus membrane) and induction of antioxidant enzymes.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY, USA. okezie.aruoma@touro.edu
authors.forename: Okezie I
authors.initials: OI
authors.lastname: Aruoma
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: Pierre
authors.initials: P
authors.lastname: Mantello
authors.forename: Eliezer
authors.initials: E
authors.lastname: Rachmilewitz
authors.forename: Luc
authors.initials: L
authors.lastname: Montagnier
mesh_terms: D000544:Alzheimer Disease / Q000178:diet therapy / Q000378:metabolism; D000740:Anemia / Q000178:diet therapy / Q000378:metabolism; D000818:Animals; D029441:Carica / Q000737:chemistry* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000378:metabolism; D019587:Dietary Supplements; D005285:Fermentation; D006801:Humans; D007249:Inflammation / Q000178:diet therapy / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D028321:Plant Preparations / Q000008:administration & dosage* / Q000737:chemistry; D013177:Sports / Q000502:physiology
chemical_list: D028321:Plant Preparations