Terminalia arjuna in cardiovascular diseases: making the transition from traditional to modern medicine in India.
The stem bark of Terminalia arjuna (Roxb.) is used by the Ayurvedic physicians in India for the treatment of various cardiovascular diseases, collectively referred to as hritroga. It has been extensively studied in animal models to demonstrate cardioprotective properties, ranging from positive inotropic- , hypolipdemic-, coronary vasodilatory- and antioxidant effects to induction of stress protein in heart. Various bioactive compounds, like triterpinoids, tannins, flavonoids and minerals have been isolated from the stem bark. A number of clinical studies have also reported its beneficial effects in patients of chronic stable angina, endothelial dysfunction, heart failure and even ischemic mitral regurgitation. However, there are some identified lacunae, like standardisation of the 'drug', toxicity studies along with pharmacological interactions with other drugs and large multicentre randomized clinical trials, before its use by modern medicine is acceptable.
Maulik
S K
SK
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India. skmaulik@gmail.com
Katiyar
C K
CK
D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002986:Clinical Trials as Topic; D005419:Flavonoids / Q000494:pharmacology*; D006333:Heart Failure / Q000188:drug therapy*; D006339:Heart Rate; D006801:Humans; D007194:India; D008515:Medicine, Ayurvedic; D009200:Myocardial Contraction; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013634:Tannins / Q000494:pharmacology; D029766:Terminalia; D014315:Triterpenes / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D000975:Antioxidants; D002316:Cardiotonic Agents; D005419:Flavonoids; D010936:Plant Extracts; D013634:Tannins; D014315:Triterpenes; D014665:Vasodilator Agents