title: In vivo effects of amorphous calcium phosphate-containing orthodontic composite on enamel demineralization around orthodontic brackets.
abstract: BACKGROUND
  The aim of this study was to evaluate the in vivo effects of an amorphous calcium phosphate-containing orthodontic composite in reducing enamel demineralization around orthodontic brackets, and to compare it with the control.
  
  
  METHODS
  Fourteen orthodontic patients were divided into two equal groups. They received brackets fitted to all first premolars, bonded with either Aegis Ortho® (The Bosworth Co.), an ACP-containing orthodontic composite (experimental group), or Concise® (3M Dental Products), a resin-based orthodontic composite (control group). After 30 days, the teeth were extracted and longitudinally sectioned, and evaluated by superficial-microhardness analysis. The determinations were made at the bracket edge cementing limits and at occlusal and cervical points 100 and 200 μm away from the edge. In all of these positions, indentations were made at depths of 10, 20, 30, 50, 70, and 90 μm from the enamel surface. Analysis of variance (ANOVA) and Tukey post hoc test was used. The statistical significance level was set at p<0.05.
  
  
  RESULTS
  The ANOVA showed statistically significant differences for position, material, depth, and their interactions (p<0.001). The multiple comparison test showed that the ACP-containing orthodontic composite was significantly more efficient than the control composite, reducing enamel demineralization in almost all evaluations (p<0.001).
  
  
  CONCLUSIONS
  Present results indicated that ACP-containing orthodontic composite for bonding orthodontic brackets successfully inhibited demineralization in vivo. This effect was localized to the area around the brackets and was statistically significant after 30 days.
authors.affiliation: Department of Orthodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey. tancanuysal@yahoo.com
authors.forename: T
authors.initials: T
authors.lastname: Uysal
authors.forename: M
authors.initials: M
authors.lastname: Amasyali
authors.forename: S
authors.initials: S
authors.lastname: Ozcan
authors.forename: A E
authors.initials: AE
authors.lastname: Koyuturk
authors.forename: M
authors.initials: M
authors.lastname: Akyol
authors.forename: D
authors.initials: D
authors.lastname: Sagdic
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000293:Adolescent; D019412:Anatomy, Cross-Sectional; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry; D002327:Cariostatic Agents / Q000008:administration & dosage*; D002364:Caseins / Q000008:administration & dosage*; D002648:Child; D003188:Composite Resins / Q000737:chemistry*; D003722:Dental Alloys / Q000737:chemistry; D001840:Dental Bonding / Q000379:methods; D003738:Dental Cements / Q000737:chemistry; D003743:Dental Enamel / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006244:Hardness; D006801:Humans; D008297:Male; D016910:Orthodontic Brackets; D019279:Resin Cements / Q000737:chemistry*; D013193:Stainless Steel / Q000737:chemistry; D013997:Time Factors; D019237:Tooth Cervix / Q000187:drug effects / Q000473:pathology; D019228:Tooth Crown / Q000187:drug effects / Q000473:pathology; D017001:Tooth Demineralization / Q000517:prevention & control*
chemical_list: C528777:Aegis Ortho adhesive; D002327:Cariostatic Agents; D002364:Caseins; D003188:Composite Resins; D003722:Dental Alloys; D003738:Dental Cements; D019279:Resin Cements; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D013193:Stainless Steel; D017438:Bisphenol A-Glycidyl Methacrylate