title: Epithelial-to-mesenchymal transition in pancreatic adenocarcinoma.
abstract: Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/ aggressiveness, and the drug resistance of pancreatic cancer cells.
authors.affiliation: INSERM U624 Cell Stress, Biology of Pancreas Stress Laboratory, Marseille, France. carla.cano@inserm.fr
authors.forename: Carla E
authors.initials: CE
authors.lastname: Cano
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Motoo
authors.forename: Juan L
authors.initials: JL
authors.lastname: Iovanna
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000378:metabolism / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051785:Smad Proteins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D051785:Smad Proteins; D016212:Transforming Growth Factor beta