title: Prasugrel as alternative treatment strategy in a case with a hypersensitivity reaction to clopidogrel.
abstract: We report a case with a hypersensitivity reaction to clopidogrel that resolved after clopidogrel discontinuation and recurred on rechallenge. The reaction included fever, tachycardia, rash and mild angioedema. As an alternative to clopidogrel, the more potent thienopyridine prasugrel was administered without any signs of an allergic reaction in the hours, days and weeks following administration.
authors.affiliation: Meander Medical Center, Department of Cardiology, Amersfoort, The Netherlands. woutervanwerkum@gmail.com
authors.forename: Jochem W
authors.initials: JW
authors.lastname: van Werkum
authors.forename: Thijs L
authors.initials: TL
authors.lastname: Braber
authors.forename: Peter W H M
authors.initials: PW
authors.lastname: Verheggen
authors.forename: Simone M
authors.initials: SM
authors.lastname: Van Der Have-Roeffel
mesh_terms: D000368:Aged; D000799:Angioedema; D000077144:Clopidogrel; D004342:Drug Hypersensitivity / Q000503:physiopathology / Q000517:prevention & control*; D005076:Exanthema; D005334:Fever; D006801:Humans; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D000068799:Prasugrel Hydrochloride; D058921:Purinergic P2Y Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D013610:Tachycardia; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013927:Thrombosis / Q000517:prevention & control; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D010879:Piperazines; D058921:Purinergic P2Y Receptor Antagonists; D013876:Thiophenes; D000077144:Clopidogrel; D000068799:Prasugrel Hydrochloride; D013988:Ticlopidine