title: EUS-guided FNA of local recurrence of pancreatic cancer after surgical resection.
abstract: BACKGROUND
  EUS-guided FNA (EUS-FNA) is a sensitive test for the preoperative diagnosis of pancreatic cancer. Its use for diagnosing local tumor recurrence after surgical resection has not been described.
  
  
  OBJECTIVE
  To determine the sensitivity of EUS-FNA for this indication.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary referral hospital in the United States.
  
  
  METHODS
  Consecutive patients referred for EUS with clinical and/or radiographic suspicion of pancreatic cancer recurrence.
  
  
  METHODS
  EUS ± FNA of retroperitoneal mass.
  
  
  METHODS
  Sensitivity of EUS-FNA.
  
  
  RESULTS
  Seventeen patients (9 male, median age 71 years) underwent EUS at a median of 17 months (range 7-46 months) after a classic Whipple procedure (n = 7), pylorus-sparing Whipple procedure (n = 7), or distal pancreatectomy (n = 3) for suspected local recurrence of pancreatic cancer. The primary tumor (median size 2.5 cm, range 1.5-7.9 cm) was located in the head in 14 patients, the body in 1, and the tail in 2. Final surgical margins at any site were positive in only 1 of 17 patients (+ retroperitoneal margin). At the time of suspected recurrence, 4 patients (24%) were asymptomatic. EUS disclosed a mass (median size 21 mm, range 12-30 mm) in 16 of 17 patients (94%). Transgastric EUS-FNA (n = 16, median 4.5 passes, range 2-10) disclosed recurrent malignancy in 13 of 16 (79%), atypical cells in 1 of 16 (7%), and benign cytology in 2 of 16 (14%). Subsequent radiographic evidence of increasing tumor burden was seen in 1 of 2 patients with benign cytology; however, follow-up for the 2 other patients with benign biopsy specimens was not available. Depending on the status of the 2 patients without available follow-up, the sensitivity, specificity, and accuracy of EUS-FNA for the diagnosis of recurrent cancer ranged from 81% to 93%, was 100%, and ranged from 81% to 93%, respectively.
  
  
  CONCLUSIONS
  Small, single-center retrospective cohort.
  
  
  CONCLUSIONS
  EUS-FNA is sensitive for the diagnosis of retroperitoneal recurrence of pancreatic cancer after surgical resection.
authors.affiliation: Department of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA.
authors.forename: John
authors.initials: J
authors.lastname: DeWitt
authors.forename: Stuart
authors.initials: S
authors.lastname: Sherman
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Haddad
authors.forename: Lee
authors.initials: L
authors.lastname: McHenry
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Cote
authors.forename: Julia K
authors.initials: JK
authors.lastname: Leblanc
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D015331:Cohort Studies; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies