title: High Efficacy of Preoperative Low-Dose Radiotherapy with Sanazole (AK-2123) for Extraskeletal Ewing's Sarcoma: A Case Report.
abstract: Extraskeletal Ewing's sarcoma is a rare soft tissue tumor that is morphologically indistinguishable from Ewing's sarcoma of bone. We report a case of extraskeletal Ewing's sarcoma with several systemic problems. A 69-year-old man presented with a 5-month history of a rapidly enlarging mass in the right thigh. Because preoperative radiotherapy with sanazole (AK-2123) contributed the tumor mass reduction down to 40% in size, the tumor was successfully resected with clear surgical margins and repaired with a musculocutaneous flap. The high efficacy of pre-operative low-dose radiotherapy with sanazole was histologically confirmed that the resected tumor specimen involved no viable tumor cells and showed 100% necrosis. Based on clinical outcomes in this case, the combined modality of pre-operative low-dose radiotherapy with hypoxic cell radiosensitizer and adequate surgical resection might provide for the useful clinical application of extraskeletal Ewing's sarcoma treatment.
authors.affiliation: Department of Orthopedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Sakabe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Murata
authors.forename: Eiichi
authors.initials: E
authors.lastname: Konishi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Koto
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Horie
authors.forename: Takaaki
authors.initials: T
authors.lastname: Matsui
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sawai
authors.forename: Hideya
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Tsutomu V
authors.initials: TV
authors.lastname: Kagiya
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kubo