title: Effect of continuous positive airway pressure treatment on the subsequent EEG spectral power and sleepiness over sustained wakefulness in patients with obstructive sleep apnea-hypopnea syndrome.
abstract: OBJECTIVE
  To determine whether sleepiness and its evolution over sustained wakefulness could be reversed by nasal continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).
  
  
  METHODS
  Twelve OSAHS patients underwent three 32-h sessions of study: one before CPAP therapy (T0), the second (T3) and the third (T6), respectively, after 3 and 6 months of therapy. Each session included one night of sleep followed by 24 h of sustained wakefulness, during which EEG recordings and subjective ratings were performed every hour.
  
  
  RESULTS
  The waking EEG in treated OSAHS patients was partially improved after 3 months of CPAP and their subjective complaint of sleepiness was normalized after 6 months. Theta power (3.9-7.8 Hz) was decreased as well as its time course during the diurnal period but beta power (12.7-29.2 Hz) remained higher.
  
  
  CONCLUSIONS
  CPAP partially reverses waking EEG abnormalities in OSAHS patients with reduced theta activity after 3 months and removes the subjective complaint of sleepiness after 6 months. Nevertheless, the persistence of increased beta activity in treated patients suggests that efforts to stay awake remain strong after CPAP treatment.
  
  
  CONCLUSIONS
  CPAP influences the EEG's time course over sustained wakefulness in a frequency-specific manner in OSAHS patients.
authors.affiliation: Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC CNRS), Strasbourg, France. Jerome.Greneche@linc.u-strasbg.fr
authors.forename: J
authors.initials: J
authors.lastname: Grenèche
authors.forename: J
authors.initials: J
authors.lastname: Krieger
authors.forename: F
authors.initials: F
authors.lastname: Bertrand
authors.forename: C
authors.initials: C
authors.lastname: Erhardt
authors.forename: A
authors.initials: A
authors.lastname: Muzet
authors.forename: P
authors.initials: P
authors.lastname: Tassi
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology*; D045422:Continuous Positive Airway Pressure; D004569:Electroencephalography; D006801:Humans; D008875:Middle Aged; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome; D014851:Wakefulness / Q000502:physiology*