Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours.
An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient's exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo.
Inoue
Masafumi
M
Agency for Science, Research and Technology, Singapore.
Barkham
Timothy
T
Leo
Yee Sin
YS
Chan
Kwai Peng
KP
Chow
Angela
A
Wong
Christopher W
CW
Tze Chuen Lee
Raphael
R
Maurer-Stroh
Sebastian
S
Lin
Raymond
R
Lin
Cui
C
D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D009154:Mutation; D053139:Oseltamivir / Q000494:pharmacology*; D058873:Pandemics; D010802:Phylogeny; D017422:Sequence Analysis, DNA / Q000379:methods; D013997:Time Factors
D000998:Antiviral Agents; D053139:Oseltamivir