Surveillance for colitis-associated colon neoplasia.
The risk of developing colon cancer is increased in colitis patients, particularly if the disease is extensive and its duration long-standing. Endoscopic guidelines have been developed with the goal of detecting early neoplastic changes prior to development of advanced malignancy. Unfortunately, the natural history of this superimposed neoplastic process in colitis appears to be very heterogeneous and poorly understood. Moreover, there are numerous confounding variables in colitis patients that limit accurate assessment of the surveillance effectiveness of colonoscopy and multi-site biopsy protocols. Although the clinical challenge posed to even the most experienced clinicians remains significant, evolving methods of endoscopic imaging may facilitate better evaluation of this highly select group of patients.
Freeman
Hugh James
HJ
Department of Medicine, University of British Columbia, Vancouver, BC V6T 1W5, Canada. hugfree@shaw.ca
D000782:Aneuploidy; D003093:Colitis, Ulcerative / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008962:Models, Theoretical; D011159:Population Surveillance; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology; D012307:Risk Factors