Expression of e-selectin in the skin of patients with atopic dermatitis: morphometric study.
Adhesion molecules may play an important role in the homing of T-cell subsets into allergen-exposed skin of atopic individuals. The aim of this study was to examine the expression of adhesion molecules in atopic dermatitis skin lesions. Biopsies were obtained from lesions in 30 adult patients with atopic dermatitis and 10 healthy adults as controls. Biopsy specimens were studied by immunohistochemistry for the expression of E-selectin in epidermis and dermis cells. Results showed significant changes in the epithelial cell expression of E-selectin, which were especially pronounced in vascular endothelium of the dermis of atopic dermatitis patients.
Marinović Kulišić
Sandra
S
University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine, University of Zagreb, Šalata 4, Zagreb, Croatia. sandra.marinovic@zg.htnet.hr
Lipozenčić
Jasna
J
Gregorović
Gordana
G
Gregurek
Gordana
G
Lacković
Gordana
G
Jurić-Lekić
Gordana
G
D000328:Adult; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000378:metabolism* / Q000473:pathology; D020405:Dermis / Q000378:metabolism; D019040:E-Selectin / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012867:Skin / Q000378:metabolism* / Q000473:pathology
D019040:E-Selectin