title: [Antimicrobic and hemolytic activity of low-molecular metabolits of brown seaweed Laminaria cichorioides Miyabe].
abstract: Antimicrobial and hemolytic activity of ethanol extract of brown seaweed Laminaria cichorioides Miyabe, its lipophilic fractions, various classes of substances of lipophilic fraction, such as chlorophylls, fucoxanthin, monogalactosyldiacylglycerols, digalactosyldiacylglycerols, sulfoquinovosyldiacylglycerols, and fatty acids were investigated. The antimicrobial activity was studied by means of yeast cells Safale S-04 and Candida albicans CMM 455, fungi Aspergillus niger CMM 4634 and Fusarium oxysporum CMM 4639, bacteria Staphylococcus aureus ATCC 21027 (gram-positive) and Escherichia coli ATCC 15034 (gram-negative) which demonstrated selective sensitivity to the studied substances. Hemolytic activity was investigated at concentrations of substances in the range of 0.2-2000 microg/ml at different pH of erythrocyte suspension. All investigated substances caused hemolysis. The dependence of hemolytic activity of substances on pH of media was determined.
authors.forename: N I
authors.initials: NI
authors.lastname: Gerasimenko
authors.forename: E L
authors.initials: EL
authors.lastname: Chaĭkina
authors.forename: N G
authors.initials: NG
authors.lastname: Busarova
authors.forename: M M
authors.initials: MM
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D006461:Hemolysis; D053878:Hemolytic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007795:Laminaria / Q000737:chemistry*; D051379:Mice; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D053878:Hemolytic Agents