Wound healing potential of ethanolic extract of Kalanchoe pinnata Lam. leaf--a preliminary study.
The extract of K. pinnata was evaluated for its wound healing activity by using excision wound model in rats. On day 11, animals treated with the ethanolic leaf extract exhibited 86.33% reduction in the wound area, compared to petroleum jelly treated control (69.36%) and the mupirocin treated standard (85.49%). The hydroxyproline content of extract treated animals was higher, as compared to control and the standard groups. Histological analysis was also consistent with the proposal that K. pinnata leaf extract exhibits significant wound healing potential. The increased rate of wound contraction and hydroxyproline content in the extract treated animals supports the claims made by traditional healers of the benefits obtained from the medicinal use of K. pinnata.
Nayak
B Shivananda
BS
Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad. shivananda.nayak@sta.uwi.edu
Marshall
Julien R
JR
Isitor
Godwin
G
D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D006909:Hydroxyproline / Q000032:analysis; D031962:Kalanchoe / Q000737:chemistry*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
D010936:Plant Extracts; D000431:Ethanol; D006909:Hydroxyproline