title: Surgical outcomes for liposarcoma of the lower limbs with synchronous pulmonary metastases.
abstract: OBJECTIVE
  Surgical resection of pulmonary metastases from soft tissues sarcomas has typically yielded disparate results, owing to the histologic heterogeneity of various series and the presentation times relative to primary tumor discovery. It was our hypothesis that with expeditious, curative surgical resection of both, primary and metastatic disease, patients with liposarcoma of the lower limb and synchronous, resectable, pulmonary metastases might achieve satisfactory outcomes.
  
  
  METHODS
  A consecutive sample clinical study, with a mean follow-up duration of 30 months. Twenty-two patients (mean age, 50 years), each presenting with a liposarcoma of the lower limb and synchronous, resectable, pulmonary metastases, underwent curative resection of both the primary mass and all pulmonary metastases within a mean of 18 days from presentation (range 9-32 days).
  
  
  RESULTS
  Mean overall survival was 28 months, disease-related survival (SE) was 9% at 5 years (±9.7%), and disease-free survival was 9% at 5 years (±7.6%).
  
  
  CONCLUSIONS
  Expeditious, curative resection of both--primary and metastatic lesions--yields acceptable near-term results, with potential for long-term survival, in patients with liposarcoma of the lower limb and synchronous pulmonary metastases.
authors.affiliation: The F.Durante Department of Surgery, University of Rome La Sapienza, Rome, Italy. giulio.illuminati@uniroma1.it
authors.forename: Giulio
authors.initials: G
authors.lastname: Illuminati
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ceccanei
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Pacilè
authors.forename: Francesco G
authors.initials: FG
authors.lastname: Calio
authors.forename: Francesco
authors.initials: F
authors.lastname: Migliano
authors.forename: Valentina
authors.initials: V
authors.lastname: Mercurio
authors.forename: Giulia
authors.initials: G
authors.lastname: Pizzardi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nigri
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008080:Liposarcoma / Q000473:pathology / Q000601:surgery*; D035002:Lower Extremity / Q000473:pathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy; D012509:Sarcoma / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult