title: Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis.
abstract: OBJECTIVE
  To determine serum adiponectin, C-reactive protein (CRP), TNF-α and IL-6 levels in impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) patients with periodontitis before and after periodontal intervention, and to investigate the relationship between T2DM and periodontitis.
  
  
  METHODS
  A total of 50 IGT and 106 T2DM patients with periodontitis were enrolled. The T2DM patients were divided into two groups: T2DM without macrovascular disease (DM1) group and T2DM with macrovascular disease (DM2) group. Each group was randomly divided into two subgroups according to whether they performed periodontal intervention. The normal control group (NC group) consisted of 30 healthy adults. The serum adiponectin, CRP, TNF-α and IL-6 levels were measured at baseline and 3 months after periodontal intervention.
  
  
  RESULTS
  The serum adiponectin levels at baseline had decreased tendency with significant difference between each two groups, while CRP, TNF-α, and IL-6 levels had increased tendency with significant difference between each two groups among NC, IGT, DM1 and DM2 groups (all P<0.01). At 3 months after periodontal intervention, the serum adiponectin levels were increased than those without periodontal intervention (all P<0.01), while CRP, IL-6 and TNF-α significantly decreased (all P<0.05) in both IGT and DM1 groups. In DM2 group, only CRP levels at 3 months after periodontal intervention were significantly decreased (P<0.05). Moreover, the HbAlc levels in T2DM patients were improved at 3 months after periodontal invention (P<0.01).
  
  
  CONCLUSIONS
  Periodontal intervention is helpful for glucose control, which may be associated with increased serum adiponectin levels and decreased inflammatory cytokine levels.
authors.affiliation: Department of Oral Medicine and Periodontology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Street, Hangzhou 310009, PR China.
authors.forename: Wei-Lian
authors.initials: WL
authors.lastname: Sun
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Chen
authors.forename: Su-Zhan
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Yue-Zhong
authors.initials: YZ
authors.lastname: Ren
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Qin
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000150:complications; D002097:C-Reactive Protein / Q000032:analysis*; D002340:Carotid Artery Diseases / Q000150:complications; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D003925:Diabetic Angiopathies / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000150:complications / Q000628:therapy; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications; D006442:Glycated Hemoglobin / Q000032:analysis; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000150:complications / Q000628:therapy; D010514:Periodontal Pocket / Q000150:complications / Q000628:therapy; D010518:Periodontitis / Q000150:complications / Q000628:therapy*; D016491:Peripheral Vascular Diseases / Q000150:complications; D016745:Root Planing; D013524:Surgical Flaps; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D052242:Adiponectin; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C499918:ADIPOQ protein, human