title: Toxic epidermal necrolysis with prominent facial pustules: a case with reactivation of human herpesvirus 7.
abstract: A 37-year-old Japanese man presented with confluent erythemas and progressive erosive lesions on the almost entire body including the oral mucosa and genitalia. This was accompanied with prominent facial pustules. Although a lymphocyte stimulation test was positive only for acetaminophen, he took other agents including carbamazepine for his depression. He was diagnosed as having toxic epidermal necrolysis with prominent facial pustules and treated by methylprednisolone pulse therapy, which resulted in a good response. During the course, human herpesvirus 7 (HHV-7) DNA was detected in his peripheral blood. The HHV-7 reactivation might be related to facial pustulosis, which is occasionally observed in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms.
authors.affiliation: Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan. wanwan@asahikawa-med.ac.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Honma
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tobisawa
authors.forename: Shin
authors.initials: S
authors.lastname: Iinuma
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibuya
authors.forename: Shigetsuna
authors.initials: S
authors.lastname: Komatsu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takahashi
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced / Q000473:pathology / Q000821:virology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D004802:Eosinophilia / Q000139:chemically induced; D016199:Herpesvirus 7, Human / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D019349:Roseolovirus Infections / Q000139:chemically induced / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D016896:Treatment Outcome; D014775:Virus Activation
chemical_list: D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D002220:Carbamazepine; D000082:Acetaminophen; D008775:Methylprednisolone