Interleukin 6 as a key regulator of muscle mass during cachexia.
Interleukin 6 (IL-6) has received significant attention for its regulatory role in muscle wasting during cachexia. This review examines the role of circulating IL-6 for decreasing muscle mass during cancer and emphasizes some of the indirect actions of IL-6 that may cause muscle wasting.
Carson
James A
JA
Division of Applied Physiology, Department of Exercise Science, Integrative Muscle Biology Lab, University of South Carolina, Columbia, SC 29208, USA. carsonj@mailbox.sc.edu
Baltgalvis
Kristen A
KA
D002100:Cachexia / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D015444:Exercise / Q000502:physiology; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D006984:Hypertrophy; D007249:Inflammation / Q000097:blood / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009369:Neoplasms / Q000150:complications; D012307:Risk Factors; D015398:Signal Transduction
D015850:Interleukin-6; D006003:Glycogen