Bioactive polymeric systems with platelet antiaggregating activity for the coating of vascular devices.
The preparation, characterization, and analysis of physicochemical and biological properties of a new bioactive polymer system, based on a copolymer of an acrylic derivative of triflusal (a molecule with chemical structure related to aspirin with antiaggregating activity for platelets) is described and evaluated as thin bioactive coating for vascular grafts and coronary stents. The acrylic monomer derived from triflusal (THEMA) provides random copolymers when it is polymerized with butyl acrylate (BA), according to their reactivity ratios, r(THEMA) = 1.05 and r(BA) = 0.33. The copolymer THBA70, containing a molar composition f(THEMA) = 0.45 and f(BA) = 0.55 presents the optimal properties of stability, flexibility, and adhesion, with a T(g) = 21 ± 2 °C, to be applied as bioactive and biostable coatings for vascular grafts and coronary stents. Thin films of this copolymer system present an excellent biocompatibility and a good inherent antiaggregant activity for platelets.
Rodríguez
G
G
Instituto de Ciencia y Tecnología de Polímeros, Consejo Superior de Investigaciones Cientificas, and CIBER-BBN, c/Juan de la Cierva 3, Madrid, Spain. gema@ictp.csic.es
Fernández-Gutiérrez
M
M
Parra
J
J
López-Bravo
A
A
Honduvilla
N G
NG
Buján
J
J
Molina
M
M
Duocastella
L
L
San Román
J
J
D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D001807:Blood Vessel Prosthesis; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D010975:Platelet Aggregation Inhibitors; D012459:Salicylates; C556105:THBA70 polymer; C016167:triflusal