Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity.
Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data. Of the isolates obtained, 1-isomangostin and garcinone E were found to be active constituents in the anticomplement assay used.
Quan
Gui-Hua
GH
Immune Modulators Research Center, Korea Research Institute of Bioscience and Biotechnology, 685-1 Ochangeup, Cheongwongun, ChungBuk 363-883, South Korea.
Oh
Sei-Ryang
SR
Kim
Jung-Hee
JH
Lee
Hyeong-Kyu
HK
Kinghorn
A Douglas
AD
Chin
Young-Won
YW
D051056:Complement Inactivating Agents / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry*; D015394:Molecular Structure; D014966:Xanthenes / Q000737:chemistry* / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
C554678:1-isomangostin; D051056:Complement Inactivating Agents; D014966:Xanthenes; D044004:Xanthones; C470472:garcinone E; C009689:xanthone