Double-blind, randomized, intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia.
BACKGROUND
Tumescent local anesthesia (TLA) with lidocaine or prilocaine solutions is widely used in dermatology.


OBJECTIVE
Comparison of efficacy and safety of lidocaine and prilocaine in liposuctions with TLA.


METHODS
TLA was performed using defined dilutions of lidocaine or prilocaine. Half-side comparisons were applied on 26 patients undergoing symmetric liposuction. Pain reduction (overall sensation and pain at lancet prick) and tolerance were assessed before, during and 2-24 h after liposuction.


RESULTS
No differences in overall pain sensation between the substances were detected during and after liposuction except a more rapid onset with lidocaine (less pain after 15 min, p < 0.043). Local tolerance of both substances was excellent.


CONCLUSIONS
Lidocaine and prilocaine used in TLA for liposuction show good efficacy and tolerance. A fixed combination of lidocaine and prilocaine may reduce the risk of side effects when great quantities of TLA are needed.
Augustin
Matthias
M
Department of Dermatology, University Clinics of Hamburg, Hamburg, Germany. m.augustin@uke.de
Maier
Kristina
K
Sommer
Boris
B
Sattler
Gerhard
G
Herberger
Katharina
K
D000328:Adult; D000772:Anesthesia, Local / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006615:Hip / Q000601:surgery; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use*; D015187:Lipectomy; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011318:Prilocaine / Q000009:adverse effects / Q000627:therapeutic use*; D013848:Thigh / Q000601:surgery
D011318:Prilocaine; D008012:Lidocaine