[Dynamic study on inhibition of qi-benefiting, blood-activating recipe on myocardial hypertrophy induced by ISO in rats].
OBJECTIVE
To observe the effect of Qi-Benefiting, Blood-Activating Recipe on the different pathologic stage of myocardial hypertrophy induced by ISO in rats.


METHODS
Myocardial hypertrophy rats were induced by isoproterenol, and treated with Qi-Benefiting, Blood-Activating Recipe for 5,10 and 15 weeks, hemodynamic parameters, LVMI, HMI were determined, ANP and BNP were analysed.


RESULTS
Qi-Benefiting, Blood-Activating Recipe could increase cardiac output and improve hemodynamic parameters all after 5, 10 and 15 weeks' treatment (P<0.05). It could decrease the contents of ANP and BNP after 5, 10 and 15 weeks' treatment (P<0.05). Qi-Benefiting, Blood-Activating Recipe could significantly decrease the levels of HWI and LVMI after 5, 10 and 15 weeks' treatment (P<0.05).


CONCLUSIONS
Qi-Benefiting, Blood-Activating Recipe can significant improve hemodynamic status, increase cardiac output and decrease the level of neurohormonal factors.
Lv
Rong
R
Department of Pathophysiology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. lvrong1025@hotmail.com
Zhang
Chen
C
Liu
Yan
Y
Gu
Yan-pin
YP
Huang
Wei
W
Guo
Wei
W
Wei
Hong-chang
HC
Chen
Li-yun
LY
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects*; D006332:Cardiomegaly / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D009206:Myocardium / Q000473:pathology; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010946:Plants, Medicinal / Q000737:chemistry; D019413:Qi; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016277:Ventricular Function, Left / Q000187:drug effects*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D007545:Isoproterenol