Determination of active substances in multicomponent veterinary preparations of antiparasitic action by HPLC method.
The study aimed at the development of an HPLC method enabling the identification and determination of the content of selected compounds occurring in multicomponent veterinary preparations used in parasitic diseases. The studied compounds included: pyrantel embonate, fenbendazole, praziquantel, epsiprantel and febantel. Using the developed HPLC method, a good separation of the above compounds was achieved. The regression analysis has shown linearity of the method in the required concentration range. The determination of the compounds mentioned and statistical evaluation of the results have demonstrated that the method is characterized by a good selectivity and high precision.
Białecka
Wanda
W
National Medicines Institute, 30/34 Chelmska St., 00-725 Warszawa, Poland. wbialecka@il.waw.pl
Kulik
Anna
A
D000977:Antiparasitic Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D057230:Limit of Detection; D019155:Veterinary Drugs / Q000032:analysis*
D000977:Antiparasitic Agents; D019155:Veterinary Drugs