Comparative evaluation of the Japanese diagnostic criteria for autoimmune pancreatitis.
OBJECTIVE
The aim of the study was to clarify the problems of the Japanese criteria for autoimmune pancreatitis (AIP) in comparison with the other criteria.


METHODS
We retrospectively investigated the clinical, imaging, serological, and histopathogic features, together with other organ involvement and response to steroid, in 50 patients with AIP diagnosed on the basis of the Japanese, Korean, HISORt, and Asian criteria. Thirty-five patients with pancreatic cancer were enrolled as a control group.


RESULTS
Forty (80%) of 50 patients received a diagnosis of AIP on the basis of the Japanese criteria. Imaging findings and serological parameters fulfilled the Japanese criteria in 40 (80%) and 50 (100%) of the patients. Pathological findings fulfilled the Japanese criteria in 6 (43%) of 14 patients. All of the 10 patients who did not have a diagnosis of AIP did not fulfill the imaging criteria. Serological parameters fulfilled the Japanese criteria in 8 (23%) of 35 patients with pancreatic cancer. The sensitivities of the Japanese, Korean, HISORt, and Asian criteria for AIP were 80%, 86%, 92%, and 82%, respectively. The specificities of those 4 criteria were 89%, 89%, 97%, and 89%, respectively.


CONCLUSIONS
The low sensitivity of imaging criteria and low specificity of serological criteria were the problems in the Japanese criteria.
Naitoh
Itaru
I
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Nakazawa
Takahiro
T
Ohara
Hirotaka
H
Ando
Tomoaki
T
Hayashi
Kazuki
K
Okumura
Fumihiro
F
Miyabe
Katsuyuki
K
Yoshida
Michihiro
M
Sano
Hitoshi
H
Takada
Hiroki
H
Kanematsu
Takayoshi
T
Joh
Takashi
T
D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007564:Japan; D007723:Korea; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D010195:Pancreatitis / Q000175:diagnosis* / Q000276:immunology; D011859:Radiography; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
D007074:Immunoglobulin G