title: Candida albicans structural and secreted proteins modulate CD4/CD8 ratio in tumor infiltrating lymphocytes of spontaneous adenocarcinoma bearing mice.
abstract: BACKGROUND
  Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer.
  
  
  OBJECTIVE
  To evaluate the effects of C. albicans structural and secreted proteins on intratumoral CD4/CD8 ratio as well as the survival rate in BALB/c tumor model.
  
  
  METHODS
  Structural and secretory proteins from C. albicans were isolated and examined for their effects on tumor growth and survival of adenocarcinoma bearing mice.
  
  
  RESULTS
  The results indicated that in mice treated with C. albicans structural protein, the survival rate significantly decreased compared with the control groups. Also, mice treated with secretory proteins showed a decrease in survival rate but it was not statistically significant (p>0.05). Investigating the frequency of tumor infiltrated CD4+ and CD8+ T lymphocytes indicated that the percentages of tumor infiltrated CD4+ T lymphocytes in response to structural and secreted proteins were higher compared to the control groups.
  
  
  CONCLUSIONS
  Our study suggests that C. albicans structural and secreted proteins modulate intratumor T lymphocyte infiltration.
authors.affiliation: Department of Medical Mycology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran, e-mail: Yadegarm@modares.ac.ir.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Holakuyee
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Yadegari
authors.forename: Zuhair Mohammad
authors.initials: ZM
authors.lastname: Hassan
authors.forename: Mansour
authors.initials: M
authors.lastname: Bayat
authors.forename: Ariyo Shahin
authors.initials: AS
authors.lastname: Jafari
authors.forename: Mohsen
authors.initials: M
authors.lastname: Abolhassani
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Amini
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mahdavi
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D000818:Animals; D016516:CD4-CD8 Ratio; D002176:Candida albicans / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D005656:Fungal Proteins / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology*; D016130:Immunophenotyping; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D010641:Phenotype; D047368:Tumor Burden / Q000187:drug effects / Q000276:immunology
chemical_list: D005656:Fungal Proteins