title: Artesunate misuse and Plasmodium falciparum malaria in traveler returning from Africa.
abstract: Plasmodium falciparum malaria developed in an African-born traveler who returned to Canada after visiting Nigeria. While there, she took artesunate prophylactically. Isolates had an elevated 50% inhibitory concentration to artemisinin, artesunate, and artemether, compared with that of other African isolates. Inappropriate use of artemisinin derivatives can reduce P. falciparum susceptibility.
authors.affiliation: University of Toronto, Toronto, Ontario, Canada.
authors.forename: Dea
authors.initials: D
authors.lastname: Shahinas
authors.forename: Rachel
authors.initials: R
authors.lastname: Lau
authors.forename: Krishna
authors.initials: K
authors.lastname: Khairnar
authors.forename: David
authors.initials: D
authors.lastname: Hancock
authors.forename: Dylan R
authors.initials: DR
authors.lastname: Pillai
mesh_terms: D000328:Adult; D000349:Africa; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000077332:Artesunate; D002170:Canada; D018890:Chemoprevention; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000469:parasitology / Q000517:prevention & control*; D009549:Nigeria; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D012651:Self Medication / Q000009:adverse effects*; D014195:Travel
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate