title: The effect of lidocaine when mixed with large gel particle hyaluronic acid filler tolerability and longevity: a six-month trial.
abstract: OBJECTIVE
  To determine if there is any effect on tolerance, adverse events or clinical outcome when lidocaine is added to large gel particle hyaluronic acid (LGP-HA).
  
  
  METHODS
  Single-centered, double-blinded, randomized, with-in patient trial, comparing patient comfort when receiving LGP-HA injections versus injections of LGP-HA mixed with lidocaine hydrochloride 2% (LGP-HA + L). Results were determined through patient questionnaires, standardized Canfield photography and blinded physician assessors. Participants were followed for six months.
  
  
  RESULTS
  Eighteen females were enrolled and completed the study. The average pain rating was significantly less when LGP-HA + L was administered as reported by participants and blinded investigators. Average rating of bruising and redness were less with LGP-HA + L, but not significant. After six months, 100 percent of participants and 100 percent of the primary and secondary blinded investigators reported no difference in clinical outcome or longevity between the different treatments. There was no difference in adverse events.
  
  
  CONCLUSIONS
  This is the first trial to report a six-month follow-up in a split-face study comparing LGP-HA + L to LGP-HA alone. All participant and investigator reports found symmetry of the NLFs at six months, thus demonstrating that the addition of lidocaine to LGP-HA does not affect longevity. Administration of LGP-HA + L is associated with less patient discomfort than administration of LGP-HA alone.
authors.affiliation: Tulane Dermatology Department, Tulane University, New Orleans, LA 70124, USA. drlupo@drmarylupo.com
authors.forename: Mary P
authors.initials: MP
authors.lastname: Lupo
authors.forename: Glenda
authors.initials: G
authors.lastname: Swetman
authors.forename: William
authors.initials: W
authors.lastname: Waller
mesh_terms: D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D003288:Contusions / Q000517:prevention & control; D003357:Cosmetic Techniques; D004311:Double-Blind Method; D004890:Erythema / Q000517:prevention & control; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D007267:Injections; D008012:Lidocaine / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D001672:Biocompatible Materials; D006820:Hyaluronic Acid; D008012:Lidocaine