title: Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies.
abstract: Two modern synthetic technologies to perform 1,3-dipolar cycloaddition reactions were compared. This study puts in evidence the power of microwave-assisted and flow-based methodologies compared to the conventional one in terms of reaction time and yield, and demonstrates the potential of flow chemistry in terms of time, automation, and scaling up opportunities.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Castellano
authors.forename: Lucia
authors.initials: L
authors.lastname: Tamborini
authors.forename: Monica
authors.initials: M
authors.lastname: Viviano
authors.forename: Andrea
authors.initials: A
authors.lastname: Pinto
authors.forename: Gianluca
authors.initials: G
authors.lastname: Sbardella
authors.forename: Paola
authors.initials: P
authors.lastname: Conti
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007555:Isoxazoles; D009570:Nitriles; D011758:Pyrroles; C013231:pyrroline