title: Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis.
abstract: We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca(2+)) concentration in neuroblastoma IMR5 cells, at least partly through Ca(2+) release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP(3)R) and ryanodine receptor (RyR) channels. This leads to Ca(2+) accumulation in mitochondria through the mitochondrial Ca(2+) uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca(2+) concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.
authors.affiliation: Institut Pasteur, Unité de Biologie des Virus Entériques, 25 rue du Dr Roux, Paris, France.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Brisac
authors.forename: François
authors.initials: F
authors.lastname: Téoulé
authors.forename: Arnaud
authors.initials: A
authors.lastname: Autret
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pelletier
authors.forename: Florence
authors.initials: F
authors.lastname: Colbère-Garapin
authors.forename: Catherine
authors.initials: C
authors.lastname: Brenner
authors.forename: Christophe
authors.initials: C
authors.lastname: Lemaire
authors.forename: Bruno
authors.initials: B
authors.lastname: Blondel
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D015153:Blotting, Western; D002118:Calcium / Q000378:metabolism*; D002458:Cell Fractionation; D045744:Cell Line, Tumor; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000209:etiology*; D011051:Poliomyelitis / Q000150:complications* / Q000378:metabolism; D017955:Poliovirus; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism
chemical_list: D053496:Inositol 1,4,5-Trisphosphate Receptors; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium