Artificial transcription factors which mediate double-strand DNA cleavage.
A new family of artificial transcription factor (ATF)-based conjugates have been designed and synthesized as potent chemical nucleases. Polyamides as the important and efficient ATFs were used to modify and activate several anchor compounds. The results demonstrate that the resulting conjugates remarkably promote the rate accelerations and non-random double-strand DNA cleavage activity. Interestingly, the cleavage activity of both the hydrolytic and oxidative agents was promoted efficiently through the modification of the ATFs.
Li
Chao
C
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 15 Beisanhuan East Road, 100029 Beijing, China.
Du
Chao
C
Tian
Hua
H
Jiang
Chao
C
Du
Min
M
Liu
Yan
Y
Qiao
Ren-Zhong
RZ
Jia
Yan-Xing
YX
Zhao
Yu-Fen
YF
D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D015195:Drug Design; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009757:Nylons / Q000737:chemistry*; D010084:Oxidation-Reduction; D014157:Transcription Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
D009757:Nylons; D014157:Transcription Factors; D004247:DNA