title: Gibberellins control fruit patterning in Arabidopsis thaliana.
abstract: The Arabidopsis basic helix-loop-helix (bHLH) proteins INDEHISCENT (IND) and ALCATRAZ (ALC) specify tissues required for fruit opening that have major roles in seed dispersal and plant domestication. Here, we show that synthesis of the phytohormone gibberellin is a direct and necessary target of IND, and that ALC interacts directly with DELLA repressors, which antagonize ALC function but are destabilized by gibberellin. Thus, the gibberellin/DELLA pathway has a key role in patterning the Arabidopsis fruit, and the interaction between DELLA and bHLH proteins, previously shown to connect gibberellin and light responses, is a versatile regulatory module also used in tissue patterning.
authors.affiliation: Cell and Developmental Biology Department, John Innes Centre, Norwich, NR4 7UH, United Kingdom.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Arnaud
authors.forename: Thomas
authors.initials: T
authors.lastname: Girin
authors.forename: Karim
authors.initials: K
authors.lastname: Sorefan
authors.forename: Sara
authors.initials: S
authors.lastname: Fuentes
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wood
authors.forename: Tom
authors.initials: T
authors.lastname: Lawrenson
authors.forename: Robert
authors.initials: R
authors.lastname: Sablowski
authors.forename: Lars
authors.initials: L
authors.lastname: Østergaard
mesh_terms: D017360:Arabidopsis / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D005638:Fruit / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D005875:Gibberellins / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Proteins; D005875:Gibberellins; C448681:ALCATRAZ protein, Arabidopsis; C484035:INDEHISCENT protein, Arabidopsis