title: Tonic T cell signalling and T cell tolerance as opposite effects of self-recognition on dendritic cells.
abstract: Naive T cells spend most of their time scanning the surface of dendritic cells (DCs), indicating that self-MHC/T cell receptor (TCR) interactions between these immune cells occur routinely in peripheral organs during the steady state. Peripheral self-MHC recognition on DCs drives seemingly opposing effects in the absence of inflammatory stimuli such as deletion of certain self-reactive T cells as well as maintenance of the T cell responsiveness to antigen, both of which shape the T cell repertoire and regulate T cell responses. Here we review recent data on the role of self-MHC recognition on steady-state DCs in the periphery and propose that interactions between T cells and steady-state DCs display an analogy with selection processes that occur in the thymus: high affinity TCR/self-MHC interactions in the periphery result in T cell deletion, while low/intermediate affinity interactions result in tonic TCR signalling that is required to keep T cells responsive to antigen.
authors.affiliation: Division of Molecular Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany. n.garcia@dkfz.de
authors.forename: Natalio
authors.initials: N
authors.lastname: Garbi
authors.forename: Günter J
authors.initials: GJ
authors.lastname: Hämmerling
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Probst
authors.forename: Maries
authors.initials: M
authors.lastname: van den Broek
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D017634:Self Tolerance / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*