A mitotic beacon reveals its nucleosome anchor.
Mitosis, nuclear envelope formation, and nucleocytoplasmic transport require chromosomes to identify themselves by enriching Ran-GTP around the chromatin fiber. In a recent Nature report, Makde et al. (2010) describe the structure of the Ran activator RCC1 anchored onto nucleosomes.
Hondele
Maria
M
EMBL International PhD Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
Ladurner
Andreas
A