Bromophenols as Candida albicans isocitrate lyase inhibitors.
A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against gram-positive and, gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl)methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans.
Oh
Ki-Bong
KB
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea.
Jeon
Heung Bae
HB
Han
Yu-Ri
YR
Lee
Yeon-Ju
YJ
Park
Jiyoung
J
Lee
So-Hyoung
SH
Yang
Dongsik
D
Kwon
Mihyun
M
Shin
Jongheon
J
Lee
Hyi-Seung
HS
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D010636:Phenols; D007522:Isocitrate Lyase