Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging.
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the ability (i) to duplicate indefinitely while maintaining pluripotency and (ii) to differentiate into cell types of all three embryonic germ layers. These two properties of ESCs and iPSCs make them potentially suitable for tissue engineering and cell replacement therapy for many different diseases, including Parkinson's disease, diabetes and heart disease. However, one critical obstacle in the clinical application of ESCs or iPSCs is the risk of teratoma formation. The emerging field of molecular imaging is allowing researchers to track transplanted ESCs or iPSCs in vivo, enabling early detection of teratomas.
Kooreman
Nigel G
NG
Department of Medicine, Division of Cardiology, Stanford University School of Medicine, 300 Pasteur Drive, Grant S140B, Stanford, CA 94305-5111, USA.
Wu
Joseph C
JC
D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000473:pathology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000473:pathology*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods; D044968:Regenerative Medicine; D013724:Teratoma / Q000473:pathology*; D023822:Tissue Engineering