title: The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms.
abstract: Hormonally active vitamin D3, 1,25-(OH)2D3, is believed to have a role in the prevention of cancer formation and in limiting the aggressiveness of cancers that do arise. Therefore,much interest is presently being focused on 1,25-(OH)2D3 and its analogues as potential treatments for various cancers including melanoma. This article discusses the evidence in favour of a role for 1,25-(OH)2D3 in protection against the progression of melanocytic lesions and also summarizes the mechanisms by which 1,25-(OH)2D3 may act to protect against melanoma development and progression.
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Pinczewski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Slominski
mesh_terms: D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D014807:Vitamin D / Q000096:biosynthesis / Q000502:physiology*
chemical_list: D014807:Vitamin D