Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women.
C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.
Nayeem
Fatima
F
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555-1109, USA.
Anderson
Karl E
KE
Nagamani
Manubai
M
Grady
James J
JJ
Lu
Lee-Jane W
LJ
D000273:Adipose Tissue; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition; D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D017697:Premenopause
D015415:Biomarkers; D006728:Hormones; D002097:C-Reactive Protein; D000469:Alkaline Phosphatase