title: Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.
abstract: Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.
authors.affiliation: PanThera Biopharma, LLC, Aiea, HI 96701, USA.
authors.forename: Guan-Sheng
authors.initials: GS
authors.lastname: Jiao
authors.forename: Seongjin
authors.initials: S
authors.lastname: Kim
authors.forename: Mahtab
authors.initials: M
authors.lastname: Moayeri
authors.forename: Lynne
authors.initials: L
authors.lastname: Cregar-Hernandez
authors.forename: Linda
authors.initials: L
authors.lastname: McKasson
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Margosiak
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Leppla
authors.forename: Alan T
authors.initials: AT
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000931:Antidotes / Q000737:chemistry / Q000494:pharmacology*; D000942:Antigens, Bacterial; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000931:Antidotes; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin