title: A scalable and integrative system for pathway bioinformatics and systems biology.
abstract: BACKGROUND
  Progress in systems biology depends on developing scalable informatics tools to predictively model, visualize, and flexibly store information about complex biological systems. Scalability of these tools, as well as their ability to integrate within larger frameworks of evolving tools, is critical to address the multi-scale and size complexity of biological systems.
  
  
  RESULTS
  Using current software technology, such as self-generation of database and object code from UML schemas, facilitates rapid updating of a scalable expert assistance system for modeling biological pathways. Distribution of key components along with connectivity to external data sources and analysis tools is achieved via a web service interface.
  
  
  BACKGROUND
  All sigmoid modeling software components and supplementary information are available through: http://www.igb.uci.edu/servers/sb.html.
authors.affiliation: Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA.
authors.forename: Behnam
authors.initials: B
authors.lastname: Compani
authors.forename: Trent
authors.initials: T
authors.lastname: Su
authors.forename: Ivan
authors.initials: I
authors.lastname: Chang
authors.forename: Jianlin
authors.initials: J
authors.lastname: Cheng
authors.forename: Kandarp H
authors.initials: KH
authors.lastname: Shah
authors.forename: Thomas
authors.initials: T
authors.lastname: Whisenant
authors.forename: Yimeng
authors.initials: Y
authors.lastname: Dou
authors.forename: Adriel
authors.initials: A
authors.lastname: Bergmann
authors.forename: Raymond
authors.initials: R
authors.lastname: Cheong
authors.forename: Barbara
authors.initials: B
authors.lastname: Wold
authors.forename: Lee
authors.initials: L
authors.lastname: Bardwell
authors.forename: Andre
authors.initials: A
authors.lastname: Levchenko
authors.forename: Pierre
authors.initials: P
authors.lastname: Baldi
authors.forename: Eric
authors.initials: E
authors.lastname: Mjolsness
mesh_terms: D019295:Computational Biology; D003195:Computer Communication Networks; D003198:Computer Simulation; D016208:Databases, Factual; D005103:Expert Systems; D020407:Internet; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D015398:Signal Transduction; D012984:Software; D049490:Systems Biology / Q000706:statistics & numerical data*; D014584:User-Computer Interface