title: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.
abstract: Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10⁻¹¹), odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10⁻¹²), OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.
authors.affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Miki
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Kyong-Ah
authors.initials: KA
authors.lastname: Yoon
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
authors.forename: Geon Kook
authors.initials: GK
authors.lastname: Lee
authors.forename: Jae Ill
authors.initials: JI
authors.lastname: Zo
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Naoya
authors.initials: N
authors.lastname: Hosono
authors.forename: Takashi
authors.initials: T
authors.lastname: Morizono
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Johji
authors.initials: J
authors.lastname: Inazawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yataro
authors.initials: Y
authors.lastname: Daigo
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins