[Autopsy case of corticosteroid-induced invasive pulmonary aspergillosis with cavity-formation].
Invasive pulmonary aspergillosis (IPA) is an important and fatal complication in the patients with neutropenic or immunosuppressed condition. In spite of intensive treatment with anti-fungal drugs, the prognosis of the patients who have been suffered from IPA is extremely poor. This case was an 85-year-old Japanese man who was diagnosed as idiopathic thrombocytopenic purpura (ITP). He underwent high-dose corticosteroids and gamma-globulin therapy. During the hospitalization, he complained respiratory symptoms, and the abnormal shadow suggesting pulmonary infiltration and cavitation was pointed out on chest imaging. He was diagnosed as IPA because of high level of serum beta-D-glucan and positive for aspergillus antigen. Although he underwent intensive care with anti-fungal drug administration and artificial respiration, he died of respiratory distress on the 68th hospitalization. Postmortem examination disclosed severe bronchopneumonia, cavitation and pulmonary arterial thrombi in both lungs. Histological examination showed widely distributed epitheloid cell granulomata with central necrosis containing aspergillus hyphae, and vasodestructive growth of fungus with occasional organized thrombi.
Sunagawa
Keishin
K
Department of Pathology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. garjyusaiga@yahoo.co.jp
Hemmi
Akihiro
A
Nishikawa
Eri
E
Iriyama
Noriyoshi
N
Yamada
Tsutomu
T
Nemoto
Norimichi
N
D000369:Aged, 80 and over; D001344:Autopsy; D001996:Bronchopneumonia / Q000209:etiology / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000209:etiology* / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D012720:Severity of Illness Index
D011239:Prednisolone; D008775:Methylprednisolone