title: Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating.
abstract: In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures.
authors.forename: Humeyra
authors.initials: H
authors.lastname: Caglayan
authors.forename: Semih
authors.initials: S
authors.lastname: Cakmakyapan
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Addae
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Pinard
authors.forename: Deniz
authors.initials: D
authors.lastname: Caliskan
authors.forename: Kadir
authors.initials: K
authors.lastname: Aslan
authors.forename: Ekmel
authors.initials: E
authors.lastname: Ozbay