title: Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women.
abstract: C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.
authors.affiliation: Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555-1109, USA.
authors.forename: Fatima
authors.initials: F
authors.lastname: Nayeem
authors.forename: Karl E
authors.initials: KE
authors.lastname: Anderson
authors.forename: Manubai
authors.initials: M
authors.lastname: Nagamani
authors.forename: James J
authors.initials: JJ
authors.lastname: Grady
authors.forename: Lee-Jane W
authors.initials: LJ
authors.lastname: Lu
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition; D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D017697:Premenopause
chemical_list: D015415:Biomarkers; D006728:Hormones; D002097:C-Reactive Protein; D000469:Alkaline Phosphatase