Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide.
The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion.
Stefulj
Jasminka
J
Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Zagreb, Croatia. stefulj@irb.hr
Mokrovic
Gordana
G
Hranilovic
Dubravka
D
Bordukalo-Niksic
Tatjana
T
Bakula
Mirko
M
Kubat
Milovan
M
Jernej
Branimir
B
D016009:Chi-Square Distribution; D015331:Cohort Studies; D017523:Croatia / Q000453:epidemiology; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016728:Self-Injurious Behavior / Q000235:genetics*; D013405:Suicide; D014365:Tryptophan Hydroxylase / Q000235:genetics*
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase