Preparation of amino alcohols condensed with carbohydrates: Evaluation of cytotoxicity and inhibitory effect on NO production.
This work reports the preparation of several amino alcohols condensed with d-arabinose, d-glucose, and d-galactose derivatives. These compounds were evaluated in vitro for their cytotoxicity and ability to decrease nitric oxide production in J774A.1 cells. Arabinofuranoside derivatives 5a, 5b and 5c showed a significant inhibition of nitric oxide production (>80% at 5 μg/mL), while the galactopyranoside derivative 8d showed a notable nitric oxide inhibitory activity (126% at 0.5 μg/mL).
Corrêa
Taís A
TA
Reis
Elaine F C
EF
Alves
Lívia L
LL
Alves
Caio C S
CC
Castro
Sandra B R
SB
Dias
Alyria T
AT
Taveira
Aline F
AF
Le Hyaric
Mireille
M
Couri
Mara R C
MR
Ferreira
Ana P
AP
De Almeida
Mauro V
MV
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D001089:Arabinose / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D005690:Galactose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*
D000605:Amino Alcohols; D002241:Carbohydrates; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D007371:Interferon-gamma; D001089:Arabinose; D005947:Glucose; D005690:Galactose