title: The use of fibrin glue in surgery of the knee.
abstract: Fibrin glue, also known as fibrin sealant, is now established as a haemostatic agent in surgery, but its role in orthopaedic surgery is neither well known nor clearly defined. Although it was originally used over 100 years ago, concerns about transmission of disease meant that it fell from favour. It is also available as a slow-release drug delivery system and as a substrate for cellular growth and tissue engineering. Consequently, it has the potential to be used in a number of ways in orthopaedic surgery. The purpose of this review is to address its use in surgery of the knee in which it appears to offer great promise.
authors.affiliation: Department of Orthopaedics, University College Hospital, 235 Euston Road, London NW1 2BU, UK. shelain.patel@doctors.org.uk
authors.forename: S
authors.initials: S
authors.lastname: Patel
authors.forename: E C
authors.initials: EC
authors.lastname: Rodriguez-Merchan
authors.forename: F S
authors.initials: FS
authors.lastname: Haddad
mesh_terms: D000818:Animals; D019645:Arthroplasty, Replacement, Knee / Q000379:methods; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects / Q000627:therapeutic use*; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D007718:Knee Injuries / Q000601:surgery; D007719:Knee Joint / Q000601:surgery*; D014014:Tissue Adhesives / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives