Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
Pfleger
Cathie M
CM
Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, USA.
Wang
Jun
J
Friedman
Lauren
L
Vittorino
Roselle
R
Conley
Lindsay M
LM
Ho
Lap
L
Fivecoat
Hayley C
HC
Pasinetti
Giulio M
GM