Spiroborate esters in the borane-mediated asymmetric synthesis of pyridyl and related heterocyclic alcohols.
The effectiveness of several spiroborate ester catalysts was investigated in the asymmetric borane reduction of 2-, 3-, 4-acetylpyridines under different reaction conditions. Highly enantiomerically enriched 1-(2-, 3- and 4-pyridyl)ethanols and 1-(heterocyclic)ethanols were obtained using 1 to 10% catalytic loads of the spiroborate 5 derived from diphenylprolinol and ethylene glycol.
Stepanenko
Viatcheslav
V
Department of Chemistry, University of Puerto Rico-Humacao, CUH Station, Humacao, Puerto Rico 00791, USA.
De Jesús
Melvin
M
Correa
Wildeliz
W
Guzmán
Irisbel
I
Vázquez
Cindybeth
C
Ortiz
Lymaris
L
Ortiz-Marciales
Margarita
M