title: Perforated peptic ulcer disease: mid-term outcome among Iranian population.
abstract: OBJECTIVE
  The aim of this study was to evaluate midterm outcome of patients with perforated peptic ulcer disease and to determine the main predictors of mid-term mortality.
  
  
  METHODS
  Demographic and clinical characteristics of 56 patients with the diagnosis of perforated peptic ulcer who were hospitalized in Taleghani Hospital over a 10-year period (19962005) were retrospectively collected, and in-hospital mortality and morbidity were determined. Patients were also followed for one month, one year and five years after the operation.
  
  
  RESULTS
  Among these patients, 85.5% were treated with omental patch closure, 7.1% underwent vagotomy pyloroplasty, 5.3% underwent concurrent vagotomy and gastrojejunostomy, and 1.8% underwent antrectomy. In-hospital mortality and morbidity were 5.3% and 48.2%, respectively. Survival rates at one month, one year and five years after the operation were 92.9%, 89.3% and 78.6%, respectively. Advanced age (p=0.001), preoperative shock (p=0.003), history of malignancy before surgery (p=0.001), treatment delay (p=0.028), intensive care unit admission (p=0.032), and size of ulcer >5 cm (p=0.043) were the main predictors of five-year mortality in the followed patients.
  
  
  CONCLUSIONS
  Mid-term mortality of treated perforated peptic ulcer disease among our population was notable, and the main predictors of mortality included advanced age, history of malignancy, treatment delay, intensive care unit admission, and ulcer size.
authors.affiliation: Department of Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Freshteh
authors.initials: F
authors.lastname: Kamani
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Moghimi
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Marashi
authors.forename: Habibollah
authors.initials: H
authors.lastname: Peyrovi
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Sheikhvatan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000401:mortality* / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult