title: Effect of N-acetylcysteine and fructose-1,6-bisphosphate in the treatment of experimental sepsis.
abstract: Sepsis is a syndrome caused by uncontrolled systemic inflammatory response of the individual, which represents a serious epidemiological problem worldwide. The aim of this study was to investigate the effect of N-acetylcysteine (NAC) and fructose-1,6-bisphosphate (FBP) in the treatment of experimental sepsis. We used rats that were divided into five experimental groups: normal control (not induced), septic control (induced using a capsule with non sterile fecal content and Escherichia coli), treated with FBP (500 mg/kg i.p.), treated with NAC (150 mg/kg i.p.), and treated with the combination of FBP with NAC. In the group treated with NAC, 16.68% of the mice survived, the FBP reduced the mortality of mice during the acute stage of the disease and increased the animals' survival time in 33.34%, and the combination of drugs had no effect. Our results show that NAC prevented the mortality of animals after septic induction. These data confirm the validity of the use of NAC in the treatment of sepsis. Our data also show that the synergistic action with FBP does not improve the picture.
authors.affiliation: Laboratório de Pesquisa em Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6681, prédio 12C, sala 263, CEP 90.619-900, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Ricardo Obalski
authors.initials: RO
authors.lastname: de Mello
authors.forename: Adroaldo
authors.initials: A
authors.lastname: Lunardelli
authors.forename: Eduardo
authors.initials: E
authors.lastname: Caberlon
authors.forename: Cristina Machado Bragança
authors.initials: CM
authors.lastname: de Moraes
authors.forename: Roberto
authors.initials: R
authors.lastname: Christ Vianna Santos
authors.forename: Vinicius Lorini
authors.initials: VL
authors.lastname: da Costa
authors.forename: Gabriela Viegas
authors.initials: GV
authors.lastname: da Silva
authors.forename: Patrícia
authors.initials: P
authors.lastname: da Silva Scherer
authors.forename: Luiz Eduardo Coimbra
authors.initials: LE
authors.lastname: Buaes
authors.forename: Denizar Alberto
authors.initials: DA
authors.lastname: da Silva Melo
authors.forename: Márcio Vinícius Fagundes
authors.initials: MV
authors.lastname: Donadio
authors.forename: Fernanda Bordignon
authors.initials: FB
authors.lastname: Nunes
authors.forename: Jarbas Rodrigues
authors.initials: JR
authors.lastname: de Oliveira
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006597:Fructose-Bisphosphatase / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D006597:Fructose-Bisphosphatase; D000111:Acetylcysteine