An update on disordered iron metabolism and iron overload.
Iron overload is a major cause of morbidity and mortality in transfusion-dependent anemias. Greater understanding of the mechanisms of iron regulation and the role of toxic iron moieties and their predilection for certain organs has enhanced our ability to better target therapies in recent years, as illustrated by the Thalassemia syndromes.
Ward
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Division of Medical Oncology and Hematology, Department of Medicine, Toronto General Hospital, University Health Network, Ont., Canada. richard.ward@uhn.on.ca
D000818:Animals; D001803:Blood Transfusion; D000077543:Deferiprone; D003676:Deferoxamine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D019190:Iron Overload / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D011728:Pyridones / Q000627:therapeutic use; D013789:Thalassemia / Q000150:complications / Q000628:therapy
D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D007501:Iron; D003676:Deferoxamine