title: [Genetic diseases and glioblastomas].
abstract: Some cancers are involved in inherited genetic syndromes. These genetic diseases are suspected of being involved in approximately 1% of gliomas. Few data are available on glioblastomas and their characteristics among these diseases. Familial syndromes known to predispose individuals to glioblastoma are neurofibromatosis type 1, Li-Fraumeni's syndrome, tuberous sclerosis, and Turcot's syndrome. This review discusses glioblastomas related to these diseases and the current knowledge on the statistical, clinical, and molecular biology data. Non-syndromic glioma families are discussed: a better understanding of molecular abnormalities in these groups should help understand the mechanisms of gliomagenesis. A case of malignant glioma requires the physician to actively search for the possibility of inherited factors and eventually suggest genetic counseling.
authors.affiliation: Service de neurochirurgie, hôpital Pasteur, CHU de Nice, 30, avenue de la voie Romaine, 06000 Nice, France. fabien.almairac@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Almairac
authors.forename: M
authors.initials: M
authors.lastname: Frenay
authors.forename: P
authors.initials: P
authors.lastname: Paquis
mesh_terms: D001932:Brain Neoplasms / Q000150:complications*; D030342:Genetic Diseases, Inborn / Q000150:complications*; D005909:Glioblastoma / Q000150:complications*; D006801:Humans