title: Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients.
abstract: Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery. Analysis of their blood samples from the perioperative period showed their MBL levels were abruptly increased at 24 hours after surgery. However, 2 patients had a subsequent drop of MBL at 48 hours, and both expired. These data indicated that the postoperative decrease of MBL may have been related with an unfavorable outcome after cardiac surgery.
authors.affiliation: Department of Anesthesiology, Division of Cardiothoracic Surgery, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA.
authors.forename: Yunfang Joan
authors.initials: YJ
authors.lastname: Hou
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Lee
authors.forename: Wilson
authors.initials: W
authors.lastname: Ko
authors.forename: Amie
authors.initials: A
authors.lastname: Kim
authors.forename: Jeanie
authors.initials: J
authors.lastname: Lee
authors.forename: Ketan
authors.initials: K
authors.lastname: Shevde
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures; D017809:Fatal Outcome; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000601:surgery*; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D037601:Mannose-Binding Lectin