title: Mechanical properties and in vitro bioactivity of Ca5(PO4)2SiO4 bioceramic.
abstract: Pure Ca(5)(PO(4))(2)SiO(4) bioceramic was first prepared by a sol-gel method using triethyl phosphate, tetraethoxysilane, and calcium nitrate tetrahydrate as original materials. Simulated body fluid (SBF) immersion tests revealed that Ca(5)(PO(4))(2)SiO(4) samples had a greater in vitro apatite-forming ability than hydroxyapatite (HA). After soaking Ca(5)(PO(4))(2)SiO(4) samples in the SBF for 1 day, bone-like apatite precipitated on the surfaces and the apatite layer became thicker with increasing the soaking time. However, few bone-like apatites precipitated on the HA samples even after soaking in the SBF for 7 days. The good in vitro bioactivity of Ca(5)(PO(4))(2)SiO(4) samples was attributed to the silanol (Si-OH) groups and greater solubility of Ca(5)(PO(4))(2)SiO(4). In addition, hot-pressed Ca(5)(PO(4))(2)SiO(4) ceramic exhibited lower bending strength and elastic modulus than hot-pressed HA, since the former had a lower relative density than the latter. The results have shown that Ca(5)(PO(4))(2)SiO(4) is a potential candidate material for bone repair.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Lu
authors.forename: Wei
authors.initials: W
authors.lastname: Duan
authors.forename: Yaping
authors.initials: Y
authors.lastname: Guo
authors.forename: Congqin
authors.initials: C
authors.lastname: Ning
mesh_terms: D001031:Apatites / Q000378:metabolism*; D001672:Biocompatible Materials / Q000378:metabolism*; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism*; D002516:Ceramics / Q000737:chemistry / Q000378:metabolism*; D017886:Durapatite / Q000378:metabolism*; D055119:Elastic Modulus; D006801:Humans; D008422:Materials Testing; D044367:Phase Transition; D033362:Powder Diffraction; D017640:Silicates / Q000737:chemistry / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D017640:Silicates; D017886:Durapatite; C020243:calcium phosphate