The link between vascular features and thrombosis.
The mechanisms of vascular control of thrombotic events remain unclear. The vasculature possesses essential anticoagulant factors that regulate coagulation. Because the endothelium-to-blood ratios are much higher in the microcirculation, it is likely that stasis contributes to thrombotic risk, due in large part to failure to rapidly access the microcirculation and to gain access to this highly anticoagulant environment. Inflammation can potentiate thrombosis in part through downregulation of the vascular anticoagulants, a process that appears to be exacerbated in aging, a well-known risk factor for thrombosis. Surgery and trauma, two major risk factors for thrombosis, result in the release of a variety of cellular components that trigger coagulation through separate mechanisms.
Esmon
Charles T
CT
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA. esmonc@omrf.org
Esmon
Naomi L
NL
D000375:Aging / Q000502:physiology; D000818:Animals; D000925:Anticoagulants / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology*; D001808:Blood Vessels / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D008833:Microcirculation / Q000502:physiology; D011486:Protein C / Q000502:physiology; D013927:Thrombosis / Q000503:physiopathology*
D000925:Anticoagulants; D011486:Protein C