title: [Variations in antihypertensive drug utilization among primary care areas in the autonomous region of Valencia (Spain)].
abstract: OBJECTIVE
  To estimate consumption of five subgroups of antihypertensive drugs by primary care areas and to analyze its variation.
  
  
  METHODS
  We performed an ecological, descriptive study of antihypertensive consumption in 239 primary care areas in the autonomous region of Valencia in 2005 followed by analysis of the variability observed. The 239 primary care areas were studied by descriptive analysis of dispensation [defined daily dose (DDD) per 1,000 inhabitants/day in pensioners (DDD/1000p/day) and in the active population (DDD/1000a/day)] and standardized consumption ratios. Small-area variation analysis was used to analyze the observed variability. Associations among dispensations of the distinct therapeutic subgroups were also analyzed.
  
  
  RESULTS
  Overall antihypertensive use in the autonomous region of Valencia in 2005 was 235.6DDD/1000/day. This consumption was concentrated in pensioners (800DDD/1000p/day vs. 73DDD/1000a/day). Consumption of antihypertensive subgroups oscillated from 442DDD/1000p/day for drugs with action on the renin-angiotensin system to 32DDD/1000p/day for doxazosin. The active population showed similar patterns. Variation in consumption was moderate, with coefficients of variation from 0.20 to 0.40 (slightly greater for the active population). Associations among dispensations of the different therapeutic subgroups were strong.
  
  
  CONCLUSIONS
  This study shows major variations in the overall consumption of antihypertensive drugs among primary care areas of the autonomous region of Valencia. These results suggest that variation may be associated with problems of underutilization in areas with lower consumption.
authors.affiliation: Centro Superior de Investigación en Salud Pública, Valencia, España. sanfelix_gab@gva.es
authors.forename: Gabriel
authors.initials: G
authors.lastname: Sanfélix-Gimeno
authors.forename: Salvador
authors.initials: S
authors.lastname: Peiró
authors.forename: Julián
authors.initials: J
authors.lastname: Librero
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011320:Primary Health Care; D013030:Spain
chemical_list: D000959:Antihypertensive Agents