title: Mixed-phenotype acute leukemia relapse in the iris.
abstract: Mixed-phenotype acute leukemia is a rare condition with no previously reported intraocular involvement. We present clinical, radiologic, and cytologic findings of leukemic intraocular relapse in a 23-month-old girl, with lineage switch presenting as conjunctivitis after allogeneic bone marrow transplantation. A diagnostic approach using fine needle aspiration is described.
authors.affiliation: University of Tennessee Health Science Center, Department of Ophthalmology, The Hamilton Eye Institute, Memphis, Tennessee 38613, USA.
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Shildkrot
authors.forename: Mihaela
authors.initials: M
authors.lastname: Onciu
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Hoehn
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Wilson
mesh_terms: D000208:Acute Disease; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D015811:Iris Neoplasms / Q000235:genetics* / Q000473:pathology*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010641:Phenotype; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology / Q000628:therapy; D012008:Recurrence; D014178:Translocation, Genetic
chemical_list: C470550:MLL-AF10 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein