[Radiation burn "innovating therapeutic approach"].
Radiation burn is a determinist effect of localized irradiation. The lesion is in good correlation with absorbed dose. Radiation burn is different from thermal burn. The evolution is spatiotemporal unpredictable with successive inflammatory waves and recurrence of necrosis. The conventional surgical treatment is rarely efficient because each surgical operative act seems to stimulate the inflammatory waves and fibro-necrosis process. The lesion can escape to this conventional surgical treatment. The new therapeutic approach combines surgery and cellular therapy with local administration of autologous mesenchymal stem cells. From 5 years, cell therapy have been an adjuvant treatment of surgery. This association is a therapeutic innovation, it's now the recommendation for conservative surgery of this very serious radiation burn.
Bey
E
E
Service de chirurgie plastique HIA Percy, Clamart, France. embeyboe@9online.fr
Doucet
C
C
Duhamel
P
P
Brachet
M
M
Prat
M
M
Bargues
L
L
Amabile
J-C
JC
Gourmelon
P
P
Lataillade
J-J
JJ
D000328:Adult; D002056:Burns / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D011832:Radiation Injuries / Q000150:complications / Q000601:surgery / Q000628:therapy*