title: Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques.
abstract: Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG, including the human neutralizing monoclonal IgG1b12, at levels insufficient to block infection, to six newborn macaques before oral challenge with simian-HIV strain SF162P3 (SHIV(SF162P3)). All of the macaques rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for six months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.
authors.affiliation: Pathobiology Program, Department of Global Health, University of Washington, Seattle, Washington, USA.
authors.forename: Cherie T
authors.initials: CT
authors.lastname: Ng
authors.forename: J Pablo
authors.initials: JP
authors.lastname: Jaworski
authors.forename: Pushpa
authors.initials: P
authors.lastname: Jayaraman
authors.forename: William F
authors.initials: WF
authors.lastname: Sutton
authors.forename: Patrick
authors.initials: P
authors.lastname: Delio
authors.forename: LaRene
authors.initials: L
authors.lastname: Kuller
authors.forename: David
authors.initials: D
authors.lastname: Anderson
authors.forename: Gary
authors.initials: G
authors.lastname: Landucci
authors.forename: Barbra A
authors.initials: BA
authors.lastname: Richardson
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Burton
authors.forename: Donald N
authors.initials: DN
authors.lastname: Forthal
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Haigwood
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D014766:Viremia / Q000276:immunology / Q000517:prevention & control*
chemical_list: D057134:Antibodies, Neutralizing; D007074:Immunoglobulin G