title: Synoxazolidinones A and B: novel bioactive alkaloids from the ascidian Synoicum pulmonaria.
abstract: Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.
authors.affiliation: Norwegian College of Fishery Science, University of Tromsø, Breivika N-9037, Tromsø, Norway. margey.tadesse@uit.no
authors.forename: Margey
authors.initials: M
authors.lastname: Tadesse
authors.forename: Morten B
authors.initials: MB
authors.lastname: Strøm
authors.forename: Johan
authors.initials: J
authors.lastname: Svenson
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
authors.forename: Bruce F
authors.initials: BF
authors.lastname: Milne
authors.forename: Veronika
authors.initials: V
authors.lastname: Tørfoss
authors.forename: Jeanette H
authors.initials: JH
authors.lastname: Andersen
authors.forename: Espen
authors.initials: E
authors.lastname: Hansen
authors.forename: Klara
authors.initials: K
authors.lastname: Stensvåg
authors.forename: Tor
authors.initials: T
authors.lastname: Haug
mesh_terms: D000818:Animals; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry*; D014561:Urochordata / Q000737:chemistry*
chemical_list: D023303:Oxazolidinones; C555088:synoxazolidinone A; C555089:synoxazolidinone B; D019791:Guanidine