title: Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.
abstract: Streptomyces clavuligerus is an important industrial strain that produces a number of antibiotics, including clavulanic acid and cephamycin C. A high-quality draft genome sequence of the S. clavuligerus NRRL 3585 strain was produced by employing a hybrid approach that involved Sanger sequencing, Roche/454 pyrosequencing, optical mapping, and partial finishing. Its genome, comprising four linear replicons, one chromosome, and four plasmids, carries numerous sets of genes involved in the biosynthesis of secondary metabolites, including a variety of antibiotics.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
authors.forename: Ju Yeon
authors.initials: JY
authors.lastname: Song
authors.forename: Haeyoung
authors.initials: H
authors.lastname: Jeong
authors.forename: Dong Su
authors.initials: DS
authors.lastname: Yu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Fischbach
authors.forename: Hong-Seog
authors.initials: HS
authors.lastname: Park
authors.forename: Jae Jong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Jeong-Sun
authors.initials: JS
authors.lastname: Seo
authors.forename: Susan E
authors.initials: SE
authors.lastname: Jensen
authors.forename: Tae Kwang
authors.initials: TK
authors.lastname: Oh
authors.forename: Kye Joon
authors.initials: KJ
authors.lastname: Lee
authors.forename: Jihyun F
authors.initials: JF
authors.lastname: Kim
mesh_terms: D053898:Biosynthetic Pathways / Q000235:genetics; D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010957:Plasmids; D017422:Sequence Analysis, DNA / Q000379:methods; D013302:Streptomyces / Q000235:genetics*
chemical_list: D004269:DNA, Bacterial