[Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome].
We investigated the association of polymorphisms of genes FGB G(-455)A and PROCC(-1654)T with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 1.14 +/- +/- 0.33 years (the maximum term 3.2 years). The group studied do not differ significantly with respect to the distributions of G(-455)A alleles and genotypes. However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles. Survival time from end point from carrier phenotype TT and CTis 2.19 +/- 0.18 r. years against 2.46 +/- 0.16 from carrier phenotype CCgene PROC. The obtained data allows to assume the important role of the genes which are responsible for functioning of system of a hemostasis, in the accelerated formation of failures at the patients who had a coronary syndrome.
Agapkina
Iu V
IuV
Nikitin
A G
AG
Brovkin
A N
AN
Pushkov
A A
AA
Evdokimova
M A
MA
Kudriashova
O Iu
OIu
Osmolovskaia
V S
VS
Minushkina
L O
LO
Kochkina
M S
MS
Selezneva
N D
ND
Dankovtseva
E N
EN
Chumakova
O S
OS
Baklanova
T N
TN
Talyzin
P A
PA
Reznichenko
N E
NE
Donetskaia
O P
OP
Tereshchenko
S N
SN
Krasil'nikova
E S
ES
Dzhaiani
N A
NA
Akatova
E V
EV
Glezer
M G
MG
Galiavich
A S
AS
Zakirova
V B
VB
Kaziolova
N A
NA
Timofeeva
I V
IV
Iagoda
A V
AV
Boeva
O I
OI
Katel'nitskaia
L I
LI
Khorolets
E V
EV
Shlyk
S V
SV
Volkova
É G
ÉG
Margarian
M P
MP
Guz'
I O
IO
Konstantinov
V O
VO
Timofeeva
A N
AN
Sidorenko
B A
BA
Zateĭshchikiov
D A
DA
Nosikov
V V
VV
D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000401:mortality*; D000483:Alleles; D018572:Disease-Free Survival; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011486:Protein C / Q000235:genetics*; D012426:Russia / Q000453:epidemiology; D015996:Survival Rate
D011486:Protein C; D005340:Fibrinogen