title: Metallocene catalyzed synthesis of fungistatic vicinal aminoalcohols under solvent free conditions.
abstract: Group 4 and 5 metallocenes, Cp(2)TiCl(2), Cp(2)ZrCl(2) and Cp(2)VCl(2), have been evaluated as catalyst in the solvent free, room temperature, preparation of vicinal aminoalcohols. The regioselectivity of the reaction and the fungistatic activity of the prepared compounds against Botrytis cinerea and Colletotrichum gloeosporioides are discussed.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, s/n, Apdo. 40, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mancilla
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Durán-Patrón
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Macías-Sánchez
authors.forename: Isidro G
authors.initials: IG
authors.lastname: Collado
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000935:Antifungal Agents; D009942:Organometallic Compounds; D012997:Solvents; C013108:metallocene