[SAYP--a novel regulator of metazoan development].
SAYP is a dual-function transcriptional coactivator of RNA polymerase II. It is a metazoan-specific factor involved in different signaling pathways that control normal development. In Drosophila, SAYP is present in the organism from the early stages of development and participates in cell cycle synchronization at the blastoderm stage. SAYP is abundant in many embryonic cells and in imaginal discs of larvae and is crucial for oogenesis in adults. At the molecular level, SAYP serves as a basis for assembling the BTFly nuclear supercomplex consising of the Brahma and TFIID coactivators. We suppose that BTFly and other similar nuclear supercomplexes play an important role in ontogenesis.
Kuz'mina
Iu L
IuL
Panov
V V
VV
Vorob'eva
N E
NE
Soshnikova
N V
NV
Kopantseva
M R
MR
Nikolenko
Iu V
IuV
Nabirochkina
E N
EN
Georgieva
S G
SG
Shidlovskiĭ
Iu V
IuV
D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry; D004330:Drosophila / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry; D009154:Mutation; D009363:Neoplasm Proteins / Q000378:metabolism; D009928:Organ Specificity; D015534:Trans-Activators / Q000737:chemistry; D035362:Transcription Factor TFIID / Q000737:chemistry; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016335:Zinc Fingers
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D046912:Multiprotein Complexes; D009363:Neoplasm Proteins; C552094:PHF10 protein, human; D015534:Trans-Activators; D035362:Transcription Factor TFIID; D014157:Transcription Factors; C086469:brm protein, Drosophila; C499490:e(y)3 protein, Drosophila