title: Methacrylate monomers lower the level of reduced glutathione and increase the in vitro sensitivity of cells to optical radiation.
abstract: Induction of cell death by optical radiation in the wavelength range 350-500 nm was significantly increased by commonly used methacrylate monomers, not mediated by absorption of radiation by the methacrylate monomers, but through a mechanism involving rapid reduction in the level of glutathione (GSH).
authors.affiliation: NIOM - Nordic Institute of Dental Materials, P.O. Box 70, NO-1305, Haslum, Norway. terje.christensen@nrpa.no
authors.forename: Terje
authors.initials: T
authors.lastname: Christensen
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Bruzell
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D005978:Glutathione / Q000378:metabolism*; D008689:Methacrylates / Q000737:chemistry* / Q000633:toxicity; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry / Q000633:toxicity; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000633:toxicity; D011827:Radiation; D051381:Rats
chemical_list: D008689:Methacrylates; D011109:Polymethacrylic Acids; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; C005044:hydroxyethyl methacrylate; D005978:Glutathione