In vitro antitumor activity of N-glycosyl sulfonamides.
A series of α-D-hex-2-enopyranosyl sulfonamides was evaluated for their antiproliferative activity against human hepatocellular liver carcinoma (HepG2) and human lung adenocarcinoma (A549) cell lines. The most potent compound (2,4,6-tri-O-acetyl-3-deoxy-α-D-erythro-hex-2-enopyranosyl ethanesulfonamide) showed antiproliferative properties in the micromolar range. The SARs of these sulfonamidoglycoside which includes the influence of carbohydrate rings and sulfonamide class are described.
Crespo
Rosana
R
Instituto de Investigaciones Bioquímicas de La Plata (UNLP-CONICET CCT La Plata), 60 y 120. (1900) La Plata, Argentina.
de Bravo
Margarita G
MG
Colinas
Pedro A
PA
Bravo
Rodolfo D
RD
D000230:Adenocarcinoma / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
D013449:Sulfonamides