title: Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents.
abstract: An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation-asymmetric reduction sequence.
authors.affiliation: Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Francesco G
authors.initials: FG
authors.lastname: Mutti
authors.forename: Andreas
authors.initials: A
authors.lastname: Orthaber
authors.forename: Joerg H
authors.initials: JH
authors.lastname: Schrittwieser
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
authors.forename: Rudolf
authors.initials: R
authors.lastname: Pietschnig
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
mesh_terms: D002384:Catalysis; D004798:Enzymes / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D004798:Enzymes; D007202:Indicators and Reagents; D007495:Iridium