title: Dynamics of inflammatory markers in post-acute stroke patients undergoing rehabilitation.
abstract: Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ2 = 4.81, p = 0.028, χ2 = 10.40, p = 0.005 and χ2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients' recovery.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, 8 Eroii Sanitari Street, Bucharest, Romania. manolescub@yahoo.fr
authors.forename: Bogdan Nicolae
authors.initials: BN
authors.lastname: Manolescu
authors.forename: Mihai
authors.initials: M
authors.lastname: Berteanu
authors.forename: Luminița
authors.initials: L
authors.lastname: Dumitru
authors.forename: Horațiu
authors.initials: H
authors.lastname: Dinu
authors.forename: Alina
authors.initials: A
authors.lastname: Iliescu
authors.forename: Ileana Cornelia
authors.initials: IC
authors.lastname: Fărcășanu
authors.forename: Eliza
authors.initials: E
authors.lastname: Oprea
authors.forename: Suzana
authors.initials: S
authors.lastname: Vlădoiu
authors.forename: Oana
authors.initials: O
authors.lastname: Popa
authors.forename: Olga
authors.initials: O
authors.lastname: Ianăș
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis*; D053582:Interleukin-1alpha / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D011379:Prognosis; D012046:Rehabilitation; D020521:Stroke / Q000097:blood / Q000175:diagnosis*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D053582:Interleukin-1alpha; D015850:Interleukin-6; D017270:Lipoprotein(a); D014409:Tumor Necrosis Factor-alpha