Contrast sensitivity in patients with Beta-thalassemia major and sickle cell disease under regular transfusions and treatment with desferrioxamine.
OBJECTIVE
Evaluation of contrast sensitivity in patients with beta-thalassemia major and sickle cell disease which undergo regular transfusions and chelation therapy with desferrioxamine (DFX).


METHODS
We studied contrast sensitivity in 48 eyes (24 patients) with beta-thalassemia major (group A) and in 42 eyes (21 patients) with sickle cell disease (group B), compared to 60 eyes of 30 healthy individuals (control group). Contrast sensitivity was measured using B-VAT II-SG Mentor Video Aquity Tester.


RESULTS
We found no statistically significant difference between group A and group B in any spatial frequency, while we found statistically significant differences between group B and control group in all spatial frequencies studied. Between group A and control group we found statistically significant differences in spatial frequencies of 2.3, and 6 cyc/deg.


CONCLUSIONS
DFX causes retinal alterations that may explain reductions in contrast sensitivity function and justifies regular evaluations that may allow early detection of visual function deterioration.
Gorezis
Spyridon
S
Epirus Vision Center, Ioannina, Greece.
Asproudis
Ioannis
I
Chalasios
Nikolaos
N
Karali
Aikaterini
A
Tsanou
Elena
E
Peschos
Dimitrios
D
Christodoulou
Aikaterini
A
Aspiotis
Miltiadis
M