Is the yolk sac a new marker for chromosomal abnormalities in early pregnancy?
BACKGROUND
Abnormal yolk sac size is associated with fetal miscarriage. This is a case report of two pregnancies with abnormal yolk sacs.


METHODS
In one case, a twofold sac was found; in the other case, the yolk sac was not of spherical form.


CONCLUSIONS
Currently available publications demonstrate a correlation between abnormal yolk sac size and miscarriage. However, in both cases a trisomy was confirmed. It should therefore be discussed whether form and size of the yolk sac could be a marker for chromosomal abnormalities of the fetus.
Schmidt
Peter
P
Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany. info@dr-schmidt.info
Hörmansdörfer
Cindy
C
Bosselmann
Stephan
S
Elsässer
Michael
M
Scharf
Alexander
A
D000328:Adult; D015415:Biomarkers; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014314:Trisomy / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal; D015017:Yolk Sac / Q000002:abnormalities* / Q000000981:diagnostic imaging*
D015415:Biomarkers