title: Bromophenols as Candida albicans isocitrate lyase inhibitors.
abstract: A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against gram-positive and, gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl)methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans.
authors.affiliation: Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea.
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Heung Bae
authors.initials: HB
authors.lastname: Jeon
authors.forename: Yu-Ri
authors.initials: YR
authors.lastname: Han
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Park
authors.forename: So-Hyoung
authors.initials: SH
authors.lastname: Lee
authors.forename: Dongsik
authors.initials: D
authors.lastname: Yang
authors.forename: Mihyun
authors.initials: M
authors.lastname: Kwon
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D010636:Phenols; D007522:Isocitrate Lyase