title: Use of molecular imaging to differentiate liver metastasis of colorectal cancer metastasis from neuroendocrine tumor origin.
abstract: Synchronous malignant neoplasms in a single patient are well documented in the literature. It is also recognized that there is increasing incidence of synchronous non-neuroendocrine neoplasm in patients with neuroendocrine tumor (NET). We present a case, of a patient with synchronous colorectal cancer and pancreatic NET, both cancers presenting with liver metastasis. By using 18F-FDG PET and 68Ga-DOTATATE PET imaging, we showed 2 different tumor types within the liver, which was subsequently confirmed on liver biopsy. This case report shows the utility of molecular imaging using different PET peptides. These newer modalities are useful in understanding the biology of the NET and in determining the best patient management.
authors.affiliation: Royal Free Hampstead NHS trust, UK.
authors.forename: Kiran
authors.initials: K
authors.lastname: Desai
authors.forename: Jennifer
authors.initials: J
authors.lastname: Watkins
authors.forename: Nicholas
authors.initials: N
authors.lastname: Woodward
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Quigley
authors.forename: Christos
authors.initials: C
authors.lastname: Toumpanakis
authors.forename: Jamshed
authors.initials: J
authors.lastname: Bomanji
authors.forename: Martyn
authors.initials: M
authors.lastname: Caplin
mesh_terms: D001706:Biopsy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000473:pathology*; D009942:Organometallic Compounds; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D009942:Organometallic Compounds; D019788:Fluorodeoxyglucose F18; C513399:gallium Ga 68 dotatate