Serotonin syndrome in an orthopaedic patient secondary to linezolid therapy for MRSA infection.
A 67-year-old patient was admitted for incision and drainage of a recurrent methicillin-resistant Staphylococcus aureus (MRSA) hip abscess. Linezolid therapy was initiated postoperatively. Within 48 h the patient developed confusion, agitation, hypertension and acute renal failure. Citalopram was stopped and resolution of symptoms occurred within 48 h of discontinuing the offending agent. The symptoms observed in our patient were consistent with the Sternbach criteria for serotonin syndrome.
McClean
M
M
Mid-Western Regional Hospital, Dooradoyle, Limerick, Ireland. mcclean_mark@hotmail.com
Walsh
J C
JC
Condon
F
F
D000038:Abscess / Q000382:microbiology*; D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006621:Hip Joint / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D012008:Recurrence; D020230:Serotonin Syndrome / Q000139:chemically induced*; D013203:Staphylococcal Infections / Q000188:drug therapy*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid