Structural and pharmacological effects of ring-closing metathesis in peptides.
Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.
Jacobsen
Øyvind
Ø
School of Pharmacy, University of Oslo, Oslo, Norway. oyvind.jacobsen@farmasi.uio.no
Klaveness
Jo
J
Rongved
Pål
P
D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D010455:Peptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D010455:Peptides; D010456:Peptides, Cyclic