title: [Optimization of molding technics of xiaochuang granules by central composite design-response surface methodology].
abstract: OBJECTIVE
  The optimal molding technics of Xiaochuang granules was selected.
  
  
  METHODS
  The main influential factors of the molding technics included the mixed excipients' ratio, the quantity times of excipients and the ethanol concentration. The molding effect was evaluated with the yield of qualified granules and solubility. The optimal technics of Xiaochuang granules was selected by central composite design-response surface methodology.
  
  
  RESULTS
  The optimal molding technics were as follows: the quantity times of excipients was 2.0, the proportion between mixed excipents (dextrin: lactose) was 1:1, and the ethanol concentration was 65%.
  
  
  CONCLUSIONS
  The molding technics of Xiaochuang granules is reasonable, stable and reliable.
authors.affiliation: Guangxi Traditional Chinese Medical University, Nanning 530001, China. weiwei690413@eyou.com
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Chen
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Nong
authors.forename: Dan
authors.initials: D
authors.lastname: Liang
authors.forename: Chao-cheng
authors.initials: CC
authors.lastname: Deng
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
mesh_terms: D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry*; D015233:Models, Statistical; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D000431:Ethanol