title: Profile of wound healing process induced by allantoin.
abstract: OBJECTIVE
  To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods.
  
  
  METHODS
  Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model.
  
  
  RESULTS
  The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis.
  
  
  CONCLUSIONS
  This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin.
authors.affiliation: Pharmacy School, UFOP, Ouro Preto, MG, Brazil.
authors.forename: Lorena Ulhôa
authors.initials: LU
authors.lastname: Araújo
authors.forename: Andrea
authors.initials: A
authors.lastname: Grabe-Guimarães
authors.forename: Vanessa Carla Furtado
authors.initials: VC
authors.lastname: Mosqueira
authors.forename: Claudia Martins
authors.initials: CM
authors.lastname: Carneiro
authors.forename: Neila Márcia
authors.initials: NM
authors.lastname: Silva-Barcellos
mesh_terms: D000481:Allantoin / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology*; D004655:Emulsions; D005260:Female; D007090:Image Interpretation, Computer-Assisted; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D003879:Dermatologic Agents; D004655:Emulsions; D000481:Allantoin