title: Unusual presentation of gastrointestinal stromal tumor with early cerebral involvement.
abstract: Gastrointestinal stromal tumor (GIST) is a rare tumor typically arising from gastrointestinal tract. GIST very rarely metastasizes beyond abdominal cavity. Metastatic spread to the brain is anecdotal. This is a case study describing metastatic GIST with early cerebral involvement and resistance to therapy with KIT tyrosine kinase inhibitor imatinib mesylate.
authors.affiliation: Department of Oncology, Bon Secours Hospital, Cork, Republic of Ireland. fjanku@mdanderson.org
authors.forename: Filip
authors.initials: F
authors.lastname: Janku
authors.forename: David
authors.initials: D
authors.lastname: Kidney
authors.forename: John
authors.initials: J
authors.lastname: Coyne
mesh_terms: D001549:Benzamides; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D018450:Disease Progression; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D006801:Humans; D000068877:Imatinib Mesylate; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases