[Effects of acupuncture-drug compound anesthesia on perioperative inflammatory factors in patients undergoing cardiac surgery].
OBJECTIVE
To explore the effect of acupuncture-drug compound anesthesia on immune function in patients with extracorporeal circulation undergoing cardiac surgery.


METHODS
Thirty cases undergoing cardiac surgery which included atrial septal defect neoplasty, ventricular septal defect neoplasty, mitral valve replacement and pulmonary valve coarctotomy were randomly divided into group A and group B, 15 cases in each group. Group A was given general anesthesia plus acupuncture at Neiguan (PC 6), Lieque (LU 7) and Yunmen (LU 2), and group B was given simple general anesthesia. Tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-10 (IL-10) levels before and after surgery were compared.


RESULTS
The level of TNF-alpha was increased and the levels of IL-2 and IL-10 in the serum were decreased in both groups after extracorporeal circulation for 2 h and 24 h, and the ranges of all changes were more less in group A (all P < 0.05).


CONCLUSIONS
Compared with simple general anesthesia, acupuncture-drug compound anesthesia can improve immune suppression partially in the perioperative periods under the same conditions of controlling anesthesia degree.
Shan
Jiang-Gui
JG
Department of Cardiothoracic Surgery, Renji Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200127, China.
Xue
Song
S
Xu
Gen-Xing
GX
Wang
Wei-Jun
WJ
Lian
Feng
F
Liu
Sha
S
Hu
Zhen-Lei
ZL
Huang
Ri-Tai
RT
D015667:Acupuncture Analgesia; D000328:Adult; D000768:Anesthesia, General; D006348:Cardiac Surgical Procedures; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000276:immunology* / Q000601:surgery*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
D018836:Inflammation Mediators; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10