title: Impact of changes in obesity parameters on glucose metabolism and insulin resistance over a one-year period.
abstract: OBJECTIVE
  Changes in indexes of obesity, such as waist circumference (WC) and body mass index (BMI), may influence some glucose metabolism-related parameters in both obese and non-obese subjects. We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period.
  
  
  METHODS
  Data from 3213 individuals (2014 men, 1199 women) who underwent a general health screening two years running and were not taking antidiabetic medication were analyzed.
  
  
  RESULTS
  In men, percent changes in WC (%dWC) and BMI (%dBMI) were both significantly correlated with percent changes in fasting glucose (%dFG), in hemoglobin A(1C) (%dHbA(1C)), and in HOMA-IR (%dHOMA-IR). In women, these relationships were not significant except for the relationship between %dBMI and %dHOMA-IR. In a multivariate linear regression analysis using age, %dBMI, and %dWC as independent variables, %dBMI, but not %dWC, was found to be an independent predictor of %dHOMA-IR in both genders. Furthermore, in men, %dBMI was also an independent factor predicting %dFG and %dHbA(1C).
  
  
  CONCLUSIONS
  During the one-year period, a reduction in BMI, and thus weight loss, was found to be associated with the improvement of insulin sensitivity, especially in men. A reduction in WC was also associated with an improvement in insulin sensitivity in men; however, this relationship did not remain significant after controlling for changes in BMI.
authors.affiliation: Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan. asakamoto-tky@umin.ac.jp
authors.forename: Aiko
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Ei-Ichi
authors.initials: E
authors.lastname: Toda
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
mesh_terms: D015992:Body Mass Index; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D012737:Sex Factors; D055105:Waist Circumference
chemical_list: D005947:Glucose