title: [Chronic lupus erythematosus: 104 Tunisian cases].
abstract: BACKGROUND
  Chronic lupus erythematosus is a cutaneous form of lupus erythematosus, usually involving photoexposed areas.
  
  
  OBJECTIVE
  The aim of our study is to evaluate the epidemio-clinical trends, therapeutic features and outcome of patients with chronic lupus erythematosus, through a Tunisian hospital series. We have tried to compare our results with those of other African and western series.
  
  
  METHODS
  It is a retrospective study, concerning all patients with chronic lupus erythematosus, attending the Dermatology department of Charles Nicolle Hospital over an 11 years period. The patients' age, sex, clinical features, explorations results, treatment and evolution were recorded.
  
  
  RESULTS
  A total of 104 patients were included. Chronic lupus erythematosus represented 0,1 % of all the dermatitis seen over 11 years. Chronic lupus erythematosus affects young women with a ratio F/M of 1,97 and an average age of 42 years. The discoid form was the most frequent clinical shape, observed in 73 % of cases (76 patients). The face was the most frequent localization of the lesions (91%). Five patients (4.8%) presented a generalized chronic lupus erythematosus. The direct immunofluorescence in sick skin was positive in 54 % of cases. Treatment included sun avoidance and oral antimalarials drugs in the majority of cases (95%). The progression from chronic lupus erythematosus to systemic lupus erythemetosus was observed in two cases (2%).
  
  
  CONCLUSIONS
  Chronic lupus erythematosus is a relatively rare disorder in Tunisia, compared to other African countries, where prevalence is 7 to 10 times more frequent. As shown in our study, the most common clinical feature is the discoid form. The diagnosis can be confirmed by histopathological and direct immunofluorescence examination. Progression of chronic lupus erythematosus to systemic lupus erythematosus is possible, as observed in two of our patients. Thus, Patients with chronic lupus erythematosus should be continually followed up.
authors.affiliation: Service de dermatologie, Hôpital Charles Nicolle de Tunis.
authors.forename: Anis
authors.initials: A
authors.lastname: Mahfoudh
authors.forename: Aida
authors.initials: A
authors.lastname: Khaled
authors.forename: Olfa
authors.initials: O
authors.lastname: Chtourou
authors.forename: Monia
authors.initials: M
authors.lastname: Kharfi
authors.forename: Faten
authors.initials: F
authors.lastname: Zeglaoui
authors.forename: Becima
authors.initials: B
authors.lastname: Fazaa
authors.forename: Mohamed Ridha
authors.initials: MR
authors.lastname: Kamoun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014416:Tunisia; D055815:Young Adult