Effects of solid hyaluronic acid film on postoperative fibrous scar formation after strabismus surgery in animals.
OBJECTIVE
The purpose of this study was to investigate the inhibitory effect of solid hyaluronic acid-carboxymethylcellulose film on the formation of wound adhesion after strabismus surgery on rabbit eyes.


METHODS
The authors performed strabismus surgery on rabbit eyes with hyaluronic acid film applied under and above the muscles. Histological examination was performed 90 days postoperatively using Masson trichrome staining. The length of adhesion tissues in the operated area was quantitatively compared between film-treated and control eyes.


RESULTS
Hyaluronic acid film significantly prevented the formation of adhesions between muscle, conjunctiva, and sclera after strabismus surgery (t test, P < .05).


CONCLUSIONS
The current results indicate that hyaluronic acid film can inhibit the formation of postoperative adhesion around conjunctiva, muscle, and sclera to some extent. The authors conclude that this substance offers potential benefits for ophthalmic surgery, not only with strabismus surgery but also procedures such as scleral buckle.
Takeuchi
Kimio
K
Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Nakazawa
Mitsuru
M
Metoki
Tomomi
T
Yamazaki
Hitoshi
H
Miyagawa
Yasuhiro
Y
Ito
Tadashi
T
D000818:Animals; D002266:Carboxymethylcellulose Sodium; D002921:Cicatrix / Q000517:prevention & control*; D003229:Conjunctival Diseases / Q000517:prevention & control; D006820:Hyaluronic Acid; D008567:Membranes, Artificial; D009801:Oculomotor Muscles / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D015422:Scleral Diseases / Q000517:prevention & control; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium