title: An efficient and chemoselective procedure for acylal synthesis.
abstract: A novel heterogeneous efficient procedure has been developed for the chemoselective synthesis of acylals (1,1-diacetates) under solvent-free conditions. A novel catalyst prepared by the sulfuric acid catalyzed copolymerization of p-toluenesulfonic acid and paraformaldehyde displays extremely high activities for the title reactions, affording average yields over 90% within several minutes. A comparative study showed that the novel catalyst has much higher activity than other catalysts used for this purpose. Besides, the novel catalyst displays chemoselectivity for the protection of aldehydes in the presence of ketones. In addition the high acidity (4.0 mmol/g), thermal stability (200 ºC) and easy reusability make the novel catalyst one of the best choices for the process.
authors.affiliation: School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng, China.
authors.forename: Da-He
authors.initials: DH
authors.lastname: Fan
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Mao
authors.forename: Yong-Miao
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000085:Acetates / Q000138:chemical synthesis*; D000447:Aldehydes; D001557:Benzenesulfonates; D002384:Catalysis; D005557:Formaldehyde; D007659:Ketones; D011108:Polymers
chemical_list: D000085:Acetates; D000447:Aldehydes; D001557:Benzenesulfonates; D007659:Ketones; D011108:Polymers; D005557:Formaldehyde; C029501:4-toluenesulfonic acid; C003043:paraform