title: Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.
abstract: Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
authors.affiliation: Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, USA.
authors.forename: Cathie M
authors.initials: CM
authors.lastname: Pfleger
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Lauren
authors.initials: L
authors.lastname: Friedman
authors.forename: Roselle
authors.initials: R
authors.lastname: Vittorino
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Conley
authors.forename: Lap
authors.initials: L
authors.lastname: Ho
authors.forename: Hayley C
authors.initials: HC
authors.lastname: Fivecoat
authors.forename: Giulio M
authors.initials: GM
authors.lastname: Pasinetti