title: Tailored α-methylene-γ-butyrolactones and their effects on growth suppression in pancreatic carcinoma cells.
abstract: A selected series of racemic α-methylene-γ-butyrolactones (AMGBL) were synthesized via allylboration and screened against three human pancreatic cancer cell lines (Panc-1, MIA PaCa-2, and BxPC-3). This systematic study established a discernible relationship between the substitution pattern of AMGBL and their anti-proliferative activity. β,γ-diaryl-AMGBLs, particularly those with a trans-relationship exhibited higher potency than parthenolide and LC-1 against all three cell lines.
authors.affiliation: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, United States. chandran@purdue.edu
authors.forename: P Veeraraghavan
authors.initials: PV
authors.lastname: Ramachandran
authors.forename: Debarshi
authors.initials: D
authors.lastname: Pratihar
authors.forename: Hari Narayanan G
authors.initials: HN
authors.lastname: Nair
authors.forename: Matthew
authors.initials: M
authors.lastname: Walters
authors.forename: Sadie
authors.initials: S
authors.lastname: Smith
authors.forename: Michele T
authors.initials: MT
authors.lastname: Yip-Schneider
authors.forename: Huangbing
authors.initials: H
authors.lastname: Wu
authors.forename: C Max
authors.initials: CM
authors.lastname: Schmidt
mesh_terms: D015107:4-Butyrolactone / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*
chemical_list: D015107:4-Butyrolactone