title: Long-chain polyunsaturated fatty acids profile in plasma phospholipids of hyperphenylalaninemic children on unrestricted diet.
abstract: BACKGROUND
  The aim of the present study was to examine whether hyperphenylalaninemic children on unrestricted diet (MHP) may exhibit a different LCPUFA profile from PKU or healthy children in plasma phospholipids.
  
  
  METHODS
  Forty-five MHP children (age 9-14 years) were age and sex matched with 45 PKU and 45 healthy children. Fatty acids were determined and expressed as % of total fatty acids.
  
  
  RESULTS
  MHP children showed docosahexaenoic acid (DHA) levels higher than PKU children (mean difference, 0.2%; 95% confidence interval, 0.02%-0.38%), although difference was not significant after correction for multiple comparisons, and lower levels than healthy children (-0.8%; -1.01% to -0.59%). Concentration of n-3 PUFA was higher in MHP than PKU children (0.6%; 0.4% to 0.8%),
  
  
  CONCLUSIONS
  The results suggest that low DHA levels in plasma phospholipids not only are evident in PKU but also may occur in MHP children, who are on unrestricted diet, as compared to healthy children.
authors.affiliation: Department of Paediatrics, San Paolo Hospital, University of Milan, Via di Rudinì 8, 20142 Milan, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Giovannini
authors.forename: Elvira
authors.initials: E
authors.lastname: Verduci
authors.forename: Giovanni
authors.initials: G
authors.lastname: Radaelli
authors.forename: Annamaria
authors.initials: A
authors.lastname: Lammardo
authors.forename: Diego
authors.initials: D
authors.lastname: Minghetti
authors.forename: Giacomo
authors.initials: G
authors.lastname: Cagnoli
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Salvatici
authors.forename: Enrica
authors.initials: E
authors.lastname: Riva
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D015930:Diet Records; D005231:Fatty Acids, Unsaturated / Q000097:blood* / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D010661:Phenylketonurias / Q000097:blood*; D010743:Phospholipids / Q000097:blood*
chemical_list: D005231:Fatty Acids, Unsaturated; D010743:Phospholipids