title: The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells.
abstract: Stem cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells. These cells are relatively easy to obtain, appear to be pluripotent, and are immunologically immature. These cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells.
authors.affiliation: Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA. psanberg@health.usf.edu
authors.forename: Paul R
authors.initials: PR
authors.lastname: Sanberg
authors.forename: David J
authors.initials: DJ
authors.lastname: Eve
authors.forename: Alison E
authors.initials: AE
authors.lastname: Willing
authors.forename: Svitlana
authors.initials: S
authors.lastname: Garbuzova-Davis
authors.forename: Jun
authors.initials: J
authors.lastname: Tan
authors.forename: Cyndy D
authors.initials: CD
authors.lastname: Sanberg
authors.forename: Julie G
authors.initials: JG
authors.lastname: Allickson
authors.forename: L Eduardo
authors.initials: LE
authors.lastname: Cruz
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000637:transplantation; D001773:Blood Cells / Q000166:cytology*; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation