title: Organophosphate induced delayed polyneuropathy in man: an overview.
abstract: About 80 years have passed since the first cases of organophosphate induced delayed polyneuropathy (OPIDP), as the consequence of human poisoning with certain organophosphorus compounds, were described in the literature. OPIDP is a relatively rare neurodegenerative disorder in humans characterized by loss of function, ataxia and paralysis of distal parts of sensory and motor axons in peripheral nerves and ascending and descending tracts of spinal cord appearing 2-3 weeks after exposure or later. The molecular target for OPIDP is considered to be an enzyme in the nervous system known as neuropathy target esterase (NTE). This review discusses OPIDP in man with emphasis on clinical presentation, pathogenesis, molecular mechanisms, and possibilities for prevention/therapy.
authors.affiliation: Faculty of Medicine, University of Nish, Nish, Serbia. milan.jokanovic@gmail.com
authors.forename: Milan
authors.initials: M
authors.lastname: Jokanović
authors.forename: Melita
authors.initials: M
authors.lastname: Kosanović
authors.forename: Dejan
authors.initials: D
authors.lastname: Brkić
authors.forename: Predrag
authors.initials: P
authors.lastname: Vukomanović
mesh_terms: D000818:Animals; D004950:Esterases / Q000378:metabolism; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010755:Organophosphates / Q000633:toxicity*; D010766:Phosphorylation; D011115:Polyneuropathies / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology
chemical_list: D010755:Organophosphates; D004950:Esterases