Estimating the net effect of unmeasured ions in human extracellular fluid using a new mathematical model. Part II: Practical issues.
Building on the theoretical considerations developed in Part I of this two-part series, a population range was established for a new extracellular fluid acid-base parameter using Monte Carlo simulation. This new parameter the unmeasured ion excess, had a normal range of +/- 2.50 mEq/l which was slightly narrower than the normal range for the standard base excess at +/- 3.20 mmol/l. In both cases, most of this variation occurred as a result of the estimation of the bicarbonate concentration. Finally, several short clinical vignettes were explored to highlight the differences between the unmeasured ion excess and the standard base excess.
Anstey
C M
CM
Department of Critical Care Medicine, Sunshine Coast Hospital, Nambou, Queensland, Australia. chris_anstey@health.qld.gov.au
D000137:Acid-Base Imbalance; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000737:chemistry; D003198:Computer Simulation; D045604:Extracellular Fluid / Q000378:metabolism*; D006801:Humans; D007477:Ions / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009010:Monte Carlo Method
D001639:Bicarbonates; D007477:Ions