Glioblastoma with granular cell astrocytoma features: a case report and literature review.
We present the case of a 69-year old patient with a contrast enhancing, partially cystic lesion of the right temporal lobe, involving the ventricle and extending into the occipital lobe. The resected tumor showed histological features of a glioblastoma with granular cell astrocytoma features, lacking amplification of the EGFR gene region and IDH1R132H mutation. Literature review of 59 cases showed a 12-month overall survival of 11.7% for high-grade and 40% for low-grade granular cell astrocytomas. In 35% more than one cerebral lobe was affected. These extended mass effects may explain the worse prognosis despite the relatively bland histology of the granular cell component.
Schittenhelm
J
J
Institute of Brain Research, University Hospital, Eberhard Karls University of Tuebingen, Germany. jens.schittenhelm@med.uni-tuebingen.de
Psaras
T
T
D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D013702:Temporal Lobe / Q000473:pathology