title: De novo development of eosinophilic myocarditis with left ventricular assist device support as bridge to transplant.
abstract: The de novo development of myocarditis during left ventricular assist device support for dilated cardiomyopathy has not been previously described. We report a case of severe eosinophilic myocarditis associated with the use of leukotriene-receptor antagonist montelukast that developed during left ventricular assist device support accompanied by intra-device thrombus formation that was hemodynamically tolerated and subsequently discovered in the explanted heart. There may be no visible change in cardiac function as assessed by echocardiography, but the diagnosis should be entertained with the development of peripheral eosinophilia.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. pereira.naveen@mayo.edu
authors.forename: Naveen L
authors.initials: NL
authors.lastname: Pereira
authors.forename: Soon J
authors.initials: SJ
authors.lastname: Park
authors.forename: Richard C
authors.initials: RC
authors.lastname: Daly
authors.forename: Sudhir S
authors.initials: SS
authors.lastname: Kushwaha
authors.forename: William D
authors.initials: WD
authors.lastname: Edwards
mesh_terms: D000085:Acetates / Q000009:adverse effects*; D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D003521:Cyclopropanes; D004802:Eosinophilia; D005260:Female; D016027:Heart Transplantation; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008875:Middle Aged; D009205:Myocarditis / Q000209:etiology* / Q000276:immunology; D011804:Quinolines / Q000009:adverse effects*; D013440:Sulfides; D013927:Thrombosis / Q000209:etiology
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast