title: Virtual mitochondrion: towards an integrated model of oxidative phosphorylation complexes and beyond.
abstract: The modelling of OXPHOS (oxidative phosphorylation) in order to integrate all kinetic and thermodynamic aspects of chemiosmotic theory has a long history. We briefly review this history and show how new ways of modelling are required to integrate a local model of the individual respiratory complexes into a global model of OXPHOS and, beyond that, into a reliable overall model of central metabolism.
authors.affiliation: Université de Bordeaux 2, 146 rue Léo-Saignat, F 33076, Bordeaux Cedex, France. jpm@u-bordeaux2.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mazat
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fromentin
authors.forename: Margit
authors.initials: M
authors.lastname: Heiske
authors.forename: Christine
authors.initials: C
authors.lastname: Nazaret
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ransac
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D010085:Oxidative Phosphorylation