Neuroprotection by natural polyphenols: molecular mechanisms.
Polyphenols are the most abundant antioxidants in diet. These can be found in fruits, vegetables, beverages (tea, wine, juices, etc.), plants and some herbs. These compounds are capable of protecting neuronal cells in different in vivo and in vitro models through diverse intracellular targets. The focus of this review is aimed at presenting the role of some polyphenols on the molecular mechanism involve in neuroprotection through different biological processes like oxidative stress, excitotoxicity, apoptotic neuronal death, regulation of the kinase signal cascade and modulation of Ubiquitin-Proteasome pathway. The study of the molecular mechanisms involved in neuroprotection and the molecular targets of natural polyphenols are important in the discovery of a valuable tool for new and more advanced therapy in neurodegenerative diseases.
Campos-Esparza
Maria del Rosario
Mdel R
Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, México.
Torres-Ramos
Mónica Adriana
MA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents; D018384:Oxidative Stress / Q000187:drug effects; D010447:Peptide Hydrolases / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology
D005419:Flavonoids; D018696:Neuroprotective Agents; D010636:Phenols; D059808:Polyphenols; D025801:Ubiquitin; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; D002118:Calcium