title: Hemophagocytic syndrome in a patient with acute tubulointerstitial nephritis secondary to hepatitis A virus infection.
abstract: Hepatitis A virus (HAV) infection is generally a self-limited disease, but the infection in adults can be serious, to be often complicated by acute kidney injury (AKI) and rarely by virus-associated hemophagocytic syndrome (VAHS). Our patient, a 48-yr-old man, was diagnosed with HAV infection complicated by dialysis-dependent AKI. His kidney biopsy showed acute tubulointerstitial nephritis with massive infiltration of activated macrophages and T cells, and he progressively demonstrated features of VAHS. With hemodialysis and steroid treatment, he was successfully recovered.
authors.affiliation: Department of Internal Medicine, Korea University Medical College, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Eunjung
authors.initials: E
authors.lastname: Cho
authors.forename: Inhye
authors.initials: I
authors.lastname: Cha
authors.forename: Kichul
authors.initials: K
authors.lastname: Yoon
authors.forename: Ha Na
authors.initials: HN
authors.lastname: Yang
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Myung-Gyu
authors.initials: MG
authors.lastname: Kim
authors.forename: Sang-Kyung
authors.initials: SK
authors.lastname: Jo
authors.forename: Won Yong
authors.initials: WY
authors.lastname: Cho
authors.forename: Hyoung Kyu
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy; D000914:Antibodies, Viral / Q000032:analysis; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000914:Antibodies, Viral