Decarboxylative homocoupling of (hetero)aromatic carboxylic acids.
A variety of hetero(aromatic) carboxylic acids are shown to undergo decarboxylative homocoupling, mediated by a Pd/Ag system. This novel methodology for the synthesis of symmetrical biaryls avoids the use of haloarenes and organometallic compounds as starting materials.
Cornella
Josep
J
Queen Mary University of London, School of Biological and Chemical Sciences, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK.
Lahlali
Hicham
H
Larrosa
Igor
I
D001565:Benzoates / Q000138:chemical synthesis / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D002723:Chlorobenzoates; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012834:Silver / Q000737:chemistry
C522946:2-chloro-5-nitrobenzoic acid; D001565:Benzoates; D002264:Carboxylic Acids; D002723:Chlorobenzoates; D009574:Nitro Compounds; D009942:Organometallic Compounds; D012834:Silver; D010165:Palladium