title: A simple strategy for the construction of combinatorial cyclic peptoid libraries.
abstract: Here we describe a simple method that allows for rapid and easy sequence determination of cyclic peptoids. The key idea in this strategy is a post-screening "ring-opening" reaction to convert cyclic peptoids selected from a high-throughput screen into linear peptoids, which can be sequenced by tandem mass spectrometry. Thus, there is no need for encoding.
authors.affiliation: Department of Biochemistry and Molecular Biology, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Meyer
authors.forename: Hyun-Suk
authors.initials: HS
authors.lastname: Lim
mesh_terms: D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007700:Kinetics; D008856:Microscopy, Fluorescence; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry; D053719:Tandem Mass Spectrometry
chemical_list: D019151:Peptide Library; D010456:Peptides, Cyclic; D034444:Peptoids