title: Once daily dosing improves adherence to antiretroviral therapy.
abstract: We studied the association of once-daily dosing with self-reported adherence among participants of the Ontario Cohort Study who were currently taking ART and who had completed a 90-min interviewer-administered questionnaire. Suboptimal adherence was defined as missing ≥1 dose of ART in the 4 days prior to the interview. Participants (n = 779) were 85% male, 69% men having sex with men, 67% white, median age 48 years (IQR 42-54), median years of ART 9 (IQR 5-13) and median CD4 count 463 cells/mm(3) (IQR 320-638). Fifteen percent of participants reported suboptimal adherence in the 4 days prior to the interview. In a multivariable logistic regression model, participants on once daily regimens were half as likely to miss a dose during the 4 days prior to the interview. Other independent correlates of suboptimal adherence were younger age, lower positive social interaction and increased frequency of consuming > 6 alcoholic drinks on one occasion.
authors.affiliation: Division of Infectious Disease, University Health Network, Toronto, ON, Canada. raboud@lunenfeld.ca
authors.forename: Janet
authors.initials: J
authors.lastname: Raboud
authors.forename: Maggie
authors.initials: M
authors.lastname: Li
authors.forename: Sharon
authors.initials: S
authors.lastname: Walmsley
authors.forename: Curtis
authors.initials: C
authors.lastname: Cooper
authors.forename: Sandra
authors.initials: S
authors.lastname: Blitz
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Bayoumi
authors.forename: Sean
authors.initials: S
authors.lastname: Rourke
authors.forename: Sergio
authors.initials: S
authors.lastname: Rueda
authors.forename: Anita
authors.initials: A
authors.lastname: Rachlis
authors.forename: Nicole
authors.initials: N
authors.lastname: Mittmann
authors.forename: Marek
authors.initials: M
authors.lastname: Smieja
authors.forename: Evan
authors.initials: E
authors.lastname: Collins
authors.forename: Mona R
authors.initials: MR
authors.lastname: Loutfy
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D010349:Patient Compliance / Q000523:psychology* / Q000706:statistics & numerical data; D012959:Socioeconomic Factors; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents