Autobiographical memory in temporal lobe epilepsy: role of hippocampal and temporal lateral structures.
The present study was aimed at investigating the impact of hippocampal and temporal cortical lesions on remote autobiographical memories in temporal lobe epilepsy (TLE). Episodic specificity, episodic richness, and personal semantic memory from different life periods were assessed using a modified version of the Autobiographical Memory Interview (AMI) (M.D. Kopelman, A.E. Wilson, A. Baddeley, The autobiographical memory interview. Bury St. Edmunds: Thames Valley Test Co.; 1990) in 47 patients with unilateral mesial or lateral TLE and 38 healthy controls. Patients with TLE performed significantly more poorly than controls. Patients with left and right mTLE were equally moderately impaired, but patients with left lateral TLE had the most severe episodic memory deficits, particularly for childhood memories. With respect to personal semantic memory, patients with left TLE were significantly more impaired than those with right TLE, most pronounced for childhood memories. Both autobiographical memory aspects, episodic and personal semantic memory, were significantly intercorrelated, but both did not correlate with anterograde memory, indicating a structural dissociation between both functions.
Herfurth
Kirsten
K
Department of Neurology, Epilepsy Centre (ZEE), Friedrich-Alexander-University Erlangen–Nuremberg, Erlangen, Germany.
Kasper
Burkhard
B
Schwarz
Michael
M
Stefan
Hermann
H
Pauli
Elisabeth
E
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult