title: Providing optimal nutritional support on the intensive care unit: key challenges and practical solutions.
abstract: Many patients in the intensive care unit are malnourished or unable to eat. Feeding them correctly has the potential to reduce morbidity and even mortality but is a very complex procedure. The inflammatory response induced by surgery, trauma or sepsis will alter metabolism, change the ability to utilise nutrients and can lead to rapid loss of lean mass. Both overfeeding and underfeeding macronutrients can be harmful but generally it would seem optimal to give less during metabolic stress and immobility and increase in recovery. Physical intolerance of feeding such as diarrhoea or delayed gastric emptying is common in the intensive care unit. Diarrhoea can be treated with fibre or peptide feeds and anti-diarrhoeal drugs; however, the use of probiotics is controversial. Gastric dysfunction problems can often be overcome with prokinetic drugs or small bowel feeding tubes. New feeds with nutrients such as n-3 fatty acids that have the potential to attenuate excessive inflammatory responses show great promise in favourably improving metabolism and substrate utilisation. The importance of changing nutrient provision according to metabolic and physical tolerance cannot be understated and although expert groups have produced many guidelines on nutritional support of the critically ill, correct interpretation and implementation can be difficult without a dedicated nutrition health care professional such as a dietitian or a multidisciplinary nutritional support team.
authors.affiliation: Department of Nutrition and Dietetics, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. Peter.Turner@rlbuht.nhs.uk
authors.forename: Pete
authors.initials: P
authors.lastname: Turner
mesh_terms: D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D004750:Enteral Nutrition / Q000009:adverse effects; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000628:therapy*; D010288:Parenteral Nutrition / Q000009:adverse effects; D011506:Proteins / Q000008:administration & dosage
chemical_list: D015525:Fatty Acids, Omega-3; D011506:Proteins