Genetic mouse models of Parkinson's disease The state of the art.
The identification of several mutations causing familial forms of Parkinson's disease (PD) has led to the creation of multiple lines of mice expressing similar genetic alterations. These models present a unique opportunity for understanding pathophysiological mechanisms leading to PD in a mammalian brain and provide models that are suitable for the preclinical testing of new therapies. Different lines of mice recapitulate the symptoms and pathological features of PD to various extents. This chapter examines their respective advantages and highlights some of the key findings that have already emerged from the analysis of these new models of PD.
Magen
Iddo
I
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Chesselet
Marie-Françoise
MF
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000235:genetics; D002395:Catecholamines / Q000502:physiology; D006224:Cricetinae; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D051379:Mice; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D011328:Prions / Q000096:biosynthesis / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011597:Psychomotor Performance / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics; D051844:alpha-Synuclein / Q000096:biosynthesis / Q000235:genetics
D002395:Catecholamines; D010982:Platelet-Derived Growth Factor; D011328:Prions; D051844:alpha-Synuclein; D014446:Tyrosine 3-Monooxygenase; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; C495279:Lrrk2 protein, mouse; D017346:Protein Serine-Threonine Kinases; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D004298:Dopamine