title: Consequences arising from elevated surface temperatures on human blood.
abstract: Heat in blood pumps is generated by losses of the electrical motor and bearings. In the presented study the influence of tempered surfaces on bulk blood and adhesions on these surfaces was examined. Titanium alloy housing dummies were immersed in 25 mL heparinized human blood. The dummies were constantly tempered at specific temperatures (37-45 °C) over 15 min. Blood samples were withdrawn for blood parameter analysis and the determination of the plasmatic coagulation cascade. The quantities of adhesion on surfaces were determined by drained weight. Blood parameters do not alter significantly up to surface temperatures of 45 °C. In comparison to the control specimen, a drop in the platelet count can be observed, but is not significantly temperature dependent. The mean mass of adhesions at 41 °C increased up to 66% compared to 37 °C. Thus, heat generated in electrical motors and contact bearings may influence the amount of adhesions on surfaces.
authors.affiliation: Applied Medical Engineering, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. hamilton@hia.rwth-aachen.de
authors.forename: Kathrin F
authors.initials: KF
authors.lastname: Hamilton
authors.forename: Verena I
authors.initials: VI
authors.lastname: Schmidt
authors.forename: Ilona
authors.initials: I
authors.lastname: Mager
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steinseifer
mesh_terms: D000497:Alloys; D000704:Analysis of Variance; D001777:Blood Coagulation; D002448:Cell Adhesion; D004906:Erythrocyte Count; D006353:Heart-Assist Devices; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007962:Leukocytes; D010973:Platelet Adhesiveness; D010976:Platelet Count; D011474:Prosthesis Design; D013499:Surface Properties; D014025:Titanium
chemical_list: D000497:Alloys; D006454:Hemoglobins; D014025:Titanium