title: Protective effect of calcium folinate against methotrexate-induced endosalpinx damage in rats.
abstract: The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX.
authors.affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yang
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Chen
authors.forename: Han-Chu
authors.initials: HC
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Fei-Yun
authors.initials: FY
authors.lastname: Zheng
mesh_terms: D000818:Animals; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D002955:Leucovorin / Q000494:pharmacology*; D008727:Methotrexate / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020011:Protective Agents; D002955:Leucovorin; D008727:Methotrexate