title: Transcription factor binding variation in the evolution of gene regulation.
abstract: Transcription factor interactions with DNA are one of the primary mechanisms by which expression is modulated, yet their evolution remains poorly understood. Chromatin immunoprecipitation followed by microarray (ChIP-chip) or sequencing (ChIP-Seq) has revolutionized the study of protein-DNA interactions. However, only recently has attention focused on determining to what extent these regulatory interactions vary between species across entire genomes. A series of recent studies have compared in vivo binding data across a range of evolutionary distances. Binding events diverge rapidly, indicating gene regulation is an evolutionarily flexible process.
authors.affiliation: Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309, USA. robin.dowell@colorado.edu
authors.forename: Robin D
authors.initials: RD
authors.lastname: Dowell
mesh_terms: D000818:Animals; D047369:Chromatin Immunoprecipitation; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000032:analysis* / Q000235:genetics
chemical_list: D014157:Transcription Factors