Control of vascular tone by purines and pyrimidines.
In this Commentary, the roles of uridine adenosine tetraphosphate as an endothelium-derived contracting or relaxing factor described in the paper by Tölle et al. are considered and put into the wider context of the mechanisms of control of vascular tone by purinergic signalling via receptors located on both smooth muscle and endothelial cells.
Burnstock
Geoffrey
G
Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, London, UK. g.burnstock@ucl.ac.uk
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000502:physiology*; D015226:Dinucleoside Phosphates / Q000494:pharmacology / Q000502:physiology*; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011983:Receptors, Purinergic / Q000502:physiology*; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology*
D015226:Dinucleoside Phosphates; D011983:Receptors, Purinergic; C529314:uridine adenosine tetraphosphate