title: Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case-control study.
abstract: We estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castellón, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147 (44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations.
authors.affiliation: Health Promotion Unit, Centro de Salud Pública, Avda del Mar, 12, 12003 Castellón, Spain. jpuigb@terra.es
authors.forename: Joan
authors.initials: J
authors.lastname: Puig-Barberà
authors.forename: Alberto
authors.initials: A
authors.lastname: Arnedo-Pena
authors.forename: Francisco
authors.initials: F
authors.lastname: Pardo-Serrano
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Tirado-Balaguer
authors.forename: Silvia
authors.initials: S
authors.lastname: Pérez-Vilar
authors.forename: Ester
authors.initials: E
authors.lastname: Silvestre-Silvestre
authors.forename: Consuelo
authors.initials: C
authors.lastname: Calvo-Mas
authors.forename: Lourdes
authors.initials: L
authors.lastname: Safont-Adsuara
authors.forename: Montserrat
authors.initials: M
authors.lastname: Ruiz-García
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines