title: A tissue-engineering approach for stenosis of the trachea and/or cricoid.
abstract: CONCLUSIONS
  This new regenerative therapy shows great potential for the treatment of stenosis of the trachea and/or cricoids (STC).
  
  
  OBJECTIVE
  To estimate the potential of tissue-engineered artificial trachea (AT) for treatment of STC in clinical applications. We previously reported that AT was a useful material for implantation into a tracheal defect after resection of cancer. There are many causes of stenosis of the respiratory tract and STC is particularly difficult to treat.
  
  
  METHODS
  The AT was a spiral stent composed of Marlex mesh made of polypropylene and covered with collagen sponge made from porcine skin. Three patients with STC were treated by this tissue-engineering method. All of them suffered from STC caused by long endotracheal intubations. They underwent a two-stage operation. In the first operation, after resection of the stenotic regions, the edge of the tracheal cartilage was sutured to the edge of the skin. The tracheal lumen was exposed and a T-shaped cannula was inserted into the large tracheostoma. At 3 weeks to 2 months after the first operation, the trachea and skin were separated. The trimmed AT with venous blood and basic fibroblast growth factor (b-FGF) was then implanted into the cartilage defect.
  
  
  RESULTS
  Postoperatively, all patients were able to breathe easily and had no discomfort in their daily activities. Six months after the second operation, we observed enough air space in the trachea and cricoid by computed tomography (CT) imaging and fiber endoscopy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kanemaru
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hirano
authors.forename: Hiroo
authors.initials: H
authors.lastname: Umeda
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamashita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Suehiro
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Toshiki
authors.initials: T
authors.lastname: Maetani
authors.forename: Koichi
authors.initials: K
authors.lastname: Omori
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003413:Cricoid Cartilage; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007829:Laryngostenosis / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011126:Polypropylenes / Q000627:therapeutic use; D013526:Surgical Mesh; D013536:Suture Techniques; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014135:Tracheal Stenosis / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D011126:Polypropylenes