Ibuprofen induces reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA uptake in severe epithelial breast hyperplasia without atypia.
The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m-pentavalent dimercaptosuccinic acid (99mTc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia. Eight patients with histologically confirmed severe epithelial breast hyperplasia with (n  =  4) and without atypia (n  =  4) were submitted prospectively to 99mTc-(V)DMSA scintimammography before and after a 4-week course of 400 mg ibuprofen daily oral intake. Lesion to background ratios 60 minutes postinjection were calculated and compared (t-test) before and after ibuprofen administration. Prior to ibuprofen, the patients with severe epithelial hyperplasia displayed a significantly higher 99mTc-(V)DMSA uptake ratio compared to those with atypical epithelial hyperplasia (2.40 ± 0.32 vs 1.67 ± 0.09, respectively; p  =  .003). They also exhibited a more substantial percent decline in tracer uptake postibuprofen compared to women with atypical epithelial hyperplasia (62.0 ± 7.1 vs 15.0 ± 0.2, respectively; p  =  .001). Ibuprofen induces significant uptake reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA in severe epithelial breast hyperplasia without atypia. This agent could therefore constitute a potential imaging tool for monitoring chemoprophylaxis effectiveness in women at the early stages of malignant transformation.
Papantoniou
Vassilios
V
Nuclear Medicine Department, "Alexandra" University Hospital, 80 Vassilisis Sophias' Avenue, Athens 11528, Greece. vpapantoniou@gmail.com
Tsaroucha
Angeliki
A
Valsamaki
Pipitsa
P
Tsiouris
Spyridon
S
Sotiropoulou
Evangelia
E
Karianos
Theodore
T
Marinopoulos
Spyridon
S
Fothiadaki
Athina
A
Sotiropoulou
Maria
M
Archontaki
Aikaterini
A
Syrgiannis
Konstantinos
K
Dimitrakakis
Konstantinos
K
Antsaklis
Aris
A
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism* / Q000473:pathology*; D007052:Ibuprofen / Q000378:metabolism*; D008327:Mammography; D008875:Middle Aged; D011446:Prospective Studies; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D007052:Ibuprofen