title: Structural insights into chondroitin sulfate binding in pregnancy-associated malaria.
abstract: Malaria during pregnancy is caused when parasite-infected erythrocytes accumulate within the placenta through interactions between the VAR2CSA protein on the infected erythrocyte surface and placental CSPGs (chondroitin sulfate proteoglycans). This interaction is the major target for therapeutics to treat or prevent pregnancy-associated malaria. Here we review the structural characterization of CSPG-binding DBL (Duffy-binding like) domains from VAR2CSA and summarize the growing evidence that the exquisite ligand specificity of VAR2CSA results from the adoption of higher-order architecture in which these domains fold together to form a ligand-binding pocket.
authors.affiliation: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
authors.forename: Pongsak
authors.initials: P
authors.lastname: Khunrae
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Higgins
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry* / Q000378:metabolism*; D002809:Chondroitin Sulfates / Q000378:metabolism*; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000378:metabolism*; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology
chemical_list: D000953:Antigens, Protozoan; C512601:VAR2CSA protein, Plasmodium falciparum; D002809:Chondroitin Sulfates