Design and feasibility of an international study assessing the prevalence of contact allergy to fragrances in the general population: the European Dermato-Epidemiology Network Fragrance Study.
OBJECTIVE
Data on contact allergy to fragrances in the general population are limited. Data from allergological services suggest that the frequency of contact allergy to fragrances is increasing. The European Dermato-Epidemiology Network (EDEN) Fragrance Study aims to obtain reliable data on the prevalence of contact allergy to fragrances and other sensitizers of the European baseline series, in the general population of different geographical areas of Europe. We report the methodology and the reliability of instruments adopted and discuss the feasibility based on a pilot phase.


METHODS
Descriptive epidemiology survey. A random sample from the general population is selected and interviewed, and is offered patch testing in a randomized way. We specifically enquire about any skin rash reported during the previous year, and any history of reactions to products that may contain the sensitizer and/or a history of avoidance of the same products. Patch test data are linked to the questionnaire information to define clinical relevance.


RESULTS
The questionnaire showed high test-retest reliability in 94 individuals. Patch test reading also showed a high level of interrater reliability. During the pilot phase, a total of 589 participants were recruited.


CONCLUSIONS
The EDEN Fragrance Study is feasible and able to provide useful data on fragrance allergy.
Rossi
Marta
M
Centro Studi GISED, Ospedali Riuniti, Bergamo, Italy.
Coenraads
Pieter-Jan
PJ
Diepgen
Thomas
T
Svensson
Åke
Å
Elsner
Peter
P
Gonçalo
Margarida
M
Bruze
Magnus
M
Naldi
Luigi
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology*; D005060:Europe / Q000453:epidemiology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D010865:Pilot Projects; D015995:Prevalence; D011897:Random Allocation; D018401:Sample Size; D011795:Surveys and Questionnaires; D055815:Young Adult
D010476:Perfume