title: Prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults.
abstract: OBJECTIVE
  This study aims to determine the prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults.
  
  
  METHODS
  A total of 123 subjects, 56.9% males and 43.1% females, were recruited from a tertiary care hospital in Karachi, Pakistan. Questionnaires were administered to gather demographics; height, weight, and blood samples were also taken. For staging serum 25OHD, the cutoff values ≤50 nmol/L and 50.1-74.9 nmol/L were defined as deficiency and insufficiency, respectively.
  
  
  RESULTS
  The mean vitamin D level in the study subjects was 41.1±9.6 nmol/L. Of them, 90% had low serum 25OHD levels: 69.9% were deficient and 21.1% had insufficient levels of 25OHD. There was a significant negative correlation between serum 25OHD and iPTH levels.
  
  
  CONCLUSIONS
  The high prevalence of vitamin D deficiency and insufficiency showed that a high proportion of apparently healthy adults are at risk of developing musculoskeletal and other chronic diseases. Serum iPTH and serum 25OHD levels are better markers of this deficiency as compared to other markers.
authors.affiliation: Department of Pathology and Microbiology, Aga Khan University Hospital (AKUH), Karachi, Pakistan. shireen0008@yahoo.com
authors.forename: Shireen
authors.initials: S
authors.lastname: Mansoor
authors.forename: Aysha
authors.initials: A
authors.lastname: Habib
authors.forename: Farooq
authors.initials: F
authors.lastname: Ghani
authors.forename: Zafar
authors.initials: Z
authors.lastname: Fatmi
authors.forename: Salma
authors.initials: S
authors.lastname: Badruddin
authors.forename: Sarwat
authors.initials: S
authors.lastname: Mansoor
authors.forename: Imran
authors.initials: I
authors.lastname: Siddiqui
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000209:etiology; D010154:Pakistan; D010281:Parathyroid Hormone / Q000097:blood; D012307:Risk Factors; D012621:Seasons; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D