title: Prediction of the external work of the native heart from the dynamic H-Q curves of the rotary blood pumps during left heart bypass.
abstract: The ventricular performance is dependent on the drainage effect of rotary blood pumps (RBPs) and the performance of RBPs is affected by the ventricular pulsation. In this study, the interaction between the ventricle and RBPs was examined using the pressure-volume (P-V) diagram of the ventricle and dynamic head pressure-bypass flow (H-Q) curves (H, head pressure: arterial pressure minus ventricular pressure vs. Q, bypass flow) of the RBPs. We first investigated the relationships in a mock loop with a passive fill ventricle, followed by validation in ex vivo animal experiments. An apical drainage cannula with a micro-pressure sensor was especially fabricated to obtain ventricular pressure, while three pairs of ultrasonic crystals placed on the heart wall were used to derive ventricular volume. The mock loop-configured ventricular apical-descending aorta bypass revealed that the external work of the ventricle expressed by the area inside the P-V diagrams (EW(Heart) ) correlated strongly with the area inside dynamic H-Q curves (EW(VAD)), with the coefficients of correlation being R² = 0.869 ∼ 0.961. The results in the mock loop were verified in the ex vivo studies using three Shiba goats (10-25 kg in body weight), showing the correlation coefficients of R² = 0.802 ∼ 0.817. The linear regression analysis indicated that the increase in the bypass flow reduced pulsatility in the ventricle expressed in EW(Heart) as well as in EW(VAD) . Experimental results, both mock loop and animal studies, showed that the interaction between cardiac external work and H-Q performance of RBPs can be expressed by the relationships "EW(Heart) versus EW(VAD) ." The pulsatile nature of the native heart can be expressed in the area underneath the H-Q curves of RBPs EW(VAD) during left heart bypass indicating the status of the level of assistance by RBPs and the native heart function.
authors.affiliation: Department of Artificial Organs, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Kawaguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitao
authors.forename: Taro
authors.initials: T
authors.lastname: Kimura
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steinseifer
authors.forename: Setsuo
authors.initials: S
authors.lastname: Takatani
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006041:Goats; D018611:Heart Bypass, Left / Q000295:instrumentation*; D006353:Heart-Assist Devices; D016014:Linear Models; D008297:Male; D008904:Miniaturization; D023421:Models, Animal; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D011474:Prosthesis Design; D011673:Pulsatile Flow; D015203:Reproducibility of Results; D013318:Stroke Volume; D013997:Time Factors; D014160:Transducers, Pressure; D016277:Ventricular Function, Left; D017725:Ventricular Pressure