Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease.
Renal cysts, pain, and hematuria are common presentations of autosomal dominant polycystic kidney disease (ADPKD) in children. Renal function, however, is typically preserved in these patients despite increased renal volume. Since angiogenesis has been implicated in promotion of renal cyst growth in ADPKD, we measured the serum level of various angiogenic factors and early renal structural changes and cardiovascular parameters in 71 patients with ADPKD, with a mean age of 16 years. Renal structure and left ventricular mass index were measured by magnetic resonance imaging or by echocardiogram. Renal function was assessed by creatinine clearance and urinary protein excretion. Serum growth factor levels were measured by enzyme-linked immunosorbent assay. Because of skewed distributions, the various parameters are reported as log(10). Serum log(10) vascular endothelial growth factor was positively correlated with renal and cardiac structure, but negatively with creatinine clearance. Serum angiopoietin 1 levels significantly correlated with structural change in both the kidney and the heart and with urinary protein. Thus, the correlation between angiogenic growth factors with both renal and cardiac disease severity is compatible with a possible role for angiogenesis in the early progression of disease in ADPKD.
Reed
Berenice Y
BY
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA. berenice.gitomer@UCDenver.edu
Masoumi
Amirali
A
Elhassan
Elwaleed
E
McFann
Kim
K
Cadnapaphornchai
Melissa A
MA
Maahs
David M
DM
Snell-Bergeon
Janet K
JK
Schrier
Robert W
RW
D000293:Adolescent; D000328:Adult; D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D002648:Child; D003404:Creatinine / Q000652:urine; D003560:Cysts / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009389:Neovascularization, Pathologic; D016891:Polycystic Kidney, Autosomal Dominant / Q000097:blood* / Q000473:pathology; D011507:Proteinuria; D012720:Severity of Illness Index; D014463:Ultrasonography; D042442:Vascular Endothelial Growth Factors / Q000097:blood*; D055815:Young Adult
D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042442:Vascular Endothelial Growth Factors; D003404:Creatinine