title: Trypanocidal activity of lipophilic diamines and amino alcohols.
abstract: Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet.
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: C O R
authors.initials: CO
authors.lastname: Júnior
authors.forename: R O
authors.initials: RO
authors.lastname: Alves
authors.forename: C A M
authors.initials: CA
authors.lastname: Rezende
authors.forename: C F
authors.initials: CF
authors.lastname: da Costa
authors.forename: H
authors.initials: H
authors.lastname: Silva
authors.forename: M
authors.initials: M
authors.lastname: Le Hyaric
authors.forename: A P S
authors.initials: AP
authors.lastname: Fontes
authors.forename: R J
authors.initials: RJ
authors.lastname: Alves
authors.forename: A J
authors.initials: AJ
authors.lastname: Romanha
authors.forename: M V
authors.initials: MV
authors.lastname: de Almeida
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005840:Gentian Violet / Q000494:pharmacology; D015394:Molecular Structure; D012995:Solubility; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000605:Amino Alcohols; D003959:Diamines; D014344:Trypanocidal Agents; D005840:Gentian Violet