title: Non-oral treatment with ivermectin for disseminated strongyloidiasis.
abstract: Critically ill patients with disseminated strongyloidiasis may not be candidates for oral treatment. We report four patients with disseminated strongyloidiasis, believed to be unable to absorb oral therapy, who were treated with ivermectin by rectal and/or subcutaneous administration. Obtaining subcutaneous ivermectin and dosing it appropriately is a challenge. These cases underscore the need for improved access to subcutaneous ivermectin and more pharmacological data to guide use of this treatment approach.
authors.affiliation: Division of Infectious Diseases, and Department of Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York, USA. dnfusco@partners.org
authors.forename: Dahlene N
authors.initials: DN
authors.lastname: Fusco
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Downs
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Satlin
authors.forename: Meera
authors.initials: M
authors.lastname: Pahuja
authors.forename: Liz
authors.initials: L
authors.lastname: Ramos
authors.forename: Philip S
authors.initials: PS
authors.lastname: Barie
authors.forename: Lawrence
authors.initials: L
authors.lastname: Fleckenstein
authors.forename: Henry W
authors.initials: HW
authors.lastname: Murray
mesh_terms: D000285:Administration, Rectal; D000328:Adult; D000368:Aged; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013322:Strongyloidiasis / Q000188:drug therapy*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin