Craniopharyngioma in a patient with acromegaly due to a pituitary macroadenoma.
We present the first reported case of a craniopharyngioma as a second primary tumor in a patient with acromegaly due to a growth hormone (GH)-secreting pituitary adenoma. The patient was lost for follow-up for 18 years after trans-sphenoidal pituitary surgery for a GH-secreting pituitary adenoma. She presented with headaches and decreased visual acuity, and showed unsuppressed GH in an oral glucose load test with high IGF-1 levels. Brain MRI showed a suprasellar cystic mass and the patient underwent surgery for cyst drainage resulting in postoperative improvement in her vision. Biopsy of the mass confirmed the diagnosis of a craniopharyngioma. We stress the need for close follow-up of patients with acromegaly with adequate control of GH and IGF-1 levels.
El-Bilbeisi
Hazem
H
National Center for Diabetes, Endocrinology, Genetics, Amman, Jordan. elbilbeisi@hotmail.com
Ghannam
Mohammad
M
Nimri
Caramella F
CF
Ahmad
Azmi T
AT
D000172:Acromegaly / Q000209:etiology*; D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D003397:Craniopharyngioma / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*
D013006:Growth Hormone