An overview of concepts for cancer stem cells.
For many years, cancer research has focused on the adult stem cells present in malignant tumors. It is believed that current cancer treatments sometimes fail because they do not target these cells. According to classic models of carcinogenesis, these events can occur in any cell. In contrast, the cancer stem cell (CSC) hypothesis states that the preferential targets of oncogenic transformation are tissue stem cells or early progenitor cells that have acquired the potential for self-renewal. These tumor-initiating cells, or CSCs, in turn, are characterized by their ability to undergo self-renewal, a process that drives tumorigenesis and differentiation, which contributes to the cellular heterogeneity of tumors. Herein, we discuss the definitions and properties of CSCs in the major human cancers.
Chen
Shih-Yin
SY
Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Huang
Yu-Chuen
YC
Liu
Shih-Ping
SP
Tsai
Fuu-Jen
FJ
Shyu
Woei-Cherng
WC
Lin
Shinn-Zong
SZ
D001921:Brain / Q000166:cytology; D001940:Breast / Q000166:cytology; D003106:Colon / Q000166:cytology; D005260:Female; D006801:Humans; D008168:Lung / Q000166:cytology; D008297:Male; D014411:Neoplastic Stem Cells / Q000166:cytology*; D010053:Ovary / Q000166:cytology; D010179:Pancreas / Q000166:cytology; D011467:Prostate / Q000166:cytology