[Cervical dysplasia in women with human immunodeficiency virus (HIV) in areas of high prevalence of infection].
OBJECTIVE
To determine the prevalence of cervical squamous intraepithelial lesions among HIV-positive women, compared to that of HIV-negative women and identify the different types of lesions in both groups.


METHODS
Cross-sectional study conducted in 16 months in two facilities and the service of pathological anatomy of Bangui. The sample consisted of 250 HIV-positive women matched to 250 HIV-negative women. The parameters studied were the HIV status, the result of cervical smear screening, the rates of CD4 and the data of the interview.


RESULTS
The smears were inflammatory in 54.4% of HIV-negative and 46.4% of HIV-positive. Epidermoid intraepithelial lesions of the cervix were more frequent among HIV-positive women than among HIV-negative women with respectively 34.8% and 16.4% (P<0.0001). The low-grade lesions were more common regardless of HIV status of patients. The median age of onset of the LEI was lower among HIV-positive whatever the grade of the lesion. Koïlocytosis was found in 27.2% of HIV-positive women against 9.2% among HIV-negative (P<0.001).


CONCLUSIONS
The prevention of infection by HIV and HPV and the monitoring of precancerous lesions would allow to prevent their evolution towards invasive cancer.
Koffi
B
B
Service d'Anatomie Pathologique du Laboratoire National de Biologie Clinique et de Santé Publique, BP 1426 Bangui, République Centrafricaine. dockkoffi@yahoo.fr
Serdouma
E
E
Mbolissa-Nguérékoudou
W
W
Ngadjou-Kouchou-Fondjo
M
M
Pengoussou-Gbatoumba
V
V
Sépou
A
A
Grésenguet
G
G
D000328:Adult; D002488:Central African Republic / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006679:HIV Seropositivity / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology; D014626:Vaginal Smears