β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1.
In this report, we describe the convergent synthesis of β(1,3) oligosaccharides containing an aminoalkyl group. The branched heptadecasaccharide and linear hexadecasaccharide acted as ligands of dectin-1 whose binding affinity was only 10-fold weaker than that of natural SPG and exhibited dectin-1 agonist activity.
Tanaka
Hiroshi
H
Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1-H-101 Ookayama, Meguro, Tokyo, 152-8552, Japan. thiroshi@apc.titech.ac.jp
Kawai
Tetsuya
T
Adachi
Yoshiyuki
Y
Ohno
Naohito
N
Takahashi
Takashi
T
D057809:HEK293 Cells; D006801:Humans; D037181:Lectins, C-Type; D008024:Ligands; D008565:Membrane Proteins / Q000819:agonists* / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000819:agonists* / Q000378:metabolism; D009844:Oligosaccharides / Q000737:chemistry*; D011485:Protein Binding; D047071:beta-Glucans / Q000737:chemistry; D000099181:Dectin-1
D037181:Lectins, C-Type; D008024:Ligands; D008565:Membrane Proteins; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D009844:Oligosaccharides; D047071:beta-Glucans; D000099181:Dectin-1