Trypanocidal activity of lipophilic diamines and amino alcohols.
Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet.
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Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900 Juiz de Fora, MG, Brazil.
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Rezende
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da Costa
C F
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Silva
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Le Hyaric
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Fontes
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Romanha
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de Almeida
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D000605:Amino Alcohols / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005840:Gentian Violet / Q000494:pharmacology; D015394:Molecular Structure; D012995:Solubility; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D000605:Amino Alcohols; D003959:Diamines; D014344:Trypanocidal Agents; D005840:Gentian Violet