[Cytokines in bone diseases. Bone anabolic action of PTH and role of cytokine].
Parathyroid hormone (PTH) has clinically appeared as a bone anabolic reagent in Japan. Local or systemic factors produced by various cells are involved in the bone anabolic action of PTH. Insulin-like growth factor-1 and fibroblast growth factor 2 are included in them. Although the significance of canonical Wnt signaling has been noted as bone anabolic signal, recent reports indicate that an activation of Wnt signaling through several proteins, such as Dkk1 and sclerostin, are related to the bone anabolic action of PTH.
Kaji
Hiroshi
H
Divisions of Diabetes/Endocrinology and Cellular/Molecular Medicine, Kobe University Graduate School of Medicine.
Sugimoto
Toshitsugu
T
D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D016207:Cytokines / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D005819:Genetic Markers / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology*; D053245:RANK Ligand / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D016207:Cytokines; C501126:DKK1 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D010281:Parathyroid Hormone; D053245:RANK Ligand; C422903:SOST protein, human; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; D051176:beta Catenin; D016222:Fibroblast Growth Factor 2; D007334:Insulin-Like Growth Factor I