Biologically active biotin derivatives of schweinfurthin F.
As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.
Ulrich
Natalie C
NC
Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, United States.
Kuder
Craig H
CH
Hohl
Raymond J
RJ
Wiemer
David F
DF
D001710:Biotin / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D013267:Stilbenes; C518723:schweinfurthin F; D001710:Biotin