Neonatal sarcoma.
Though some neonatal soft tissue tumours have identical biology and natural history to the same tumours in older children many tumours in this age group have a distinct and more favourable behaviour and mandate less aggressive treatment; many being curable by surgical resection alone. Accurate histological diagnosis is essential. In those instances where adjunctive chemotherapy is indicated it is essential to modify paediatric chemotherapy dosages and regimes to minimise the risk of serious adverse effects. Radiotherapy should be avoided due to its severe adverse effects on growth and the risk of inducing secondary malignancies.
Spicer
Richard D
RD
University of Bristol, UK. rdspicer@hotmail.com
D017024:Chemotherapy, Adjuvant; D000075202:Contraindications; D005315:Fetal Diseases / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D017410:Practice Guidelines as Topic; D011296:Prenatal Diagnosis; D011878:Radiotherapy; D012509:Sarcoma / Q000175:diagnosis* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000628:therapy; D057832:Watchful Waiting