Tumor necrosis factor-alpha-308 G/A polymorphism and acute liver graft rejection: a meta-analysis.
BACKGROUND
Studies investigating the association between TNF-α-308 promoter polymorphism and acute rejection (AR) in liver transplant (LT) recipients report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship.


METHODS
Two investigators independently searched the Medline and Embase databases. Data were extracted using standardized forms and odds ratios (OR) with 95% confidence intervals (CI) were calculated.


RESULTS
This meta-analysis included nine case-control studies and a cohort research, which included 1104 cases of LT recipients in which 351 cases developed AR and 753 cases did not develop AR. All control samples were in Hardy-Weinberg proportion. An association between AR and A allele was not found in the overall population (OR=1.35, 95% CI=0.83, 2.22). Regarding ethnic diversity, because only 1 study was performed in Asian patients, the result of subgroup analysis by ethnicity would not be reliable for Asians. The calculated OR for A allele and AR risk in LT recipients among Caucasians was 1.36 (95% CI=0.78, 2.36). The results for the AA/AG genotype vs GG genotype showed a similar trend to those for the A allele.


CONCLUSIONS
This meta-analysis suggests that TNF-α-308 promoter polymorphism may be not associated with AR in LT recipients among Caucasians. In future, additional studies based on Asian patients should be performed to evaluate the association between TNF-α-308 G/A polymorphism and AR risk in Asian population.
Liu
Fei
F
Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Li
Bo
B
Wei
Yonggang
Y
Ma
Yu
Y
Yan
Lvnan
L
Wen
Tianfu
T
D000208:Acute Disease; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D044469:Racial Groups; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha