Expression of cyclooxygenase-2 in colonic polyps.
BACKGROUND
Limited data is available regarding the relationships between cyclooxygenase-2 (COX-2) and colorectal cancer formation.


OBJECTIVE
The aim of the study was to investigate cyclooxygenase-2 (COX-2) expression in histologically diverse colonic polyps, to determine the association between the expression of this enzyme and selected patho logical and clinical characteristics of polyps, and to establish the location of cells with high COX-2 expression within the polyp.


METHODS
We examined 212 colonic polyps from 175 patients. Immunohistochemical staining with monoclonal anti-COX-2 antibodies was performed.


RESULTS
Statistically significant differences associated with high COX-2 expression were found: in adenomas vs. other polyps (P <0.001), in adenomas with high-grade dysplasia (P <0.000 001), and in polyps of the cecum (P <0.02). Statistically significant differences in COX-2 were also associated with polyp size (P <0.000 001). Cells with high COX-2 expression were usually located in the epithelial layer (P = 0.01). No significant associations were found between high COX-2 expression and the age and sex of patients or the total number of polyps.


CONCLUSIONS
We demonstrated that high COX-2 expression is associated with typical risk factors for malignant transformation of colonic polyps. The results suggest the possible role of COX-2 in the early stages of colon carcinogenesis.
Wasilewicz
Michał P
MP
Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
Kołodziej
Blanka
B
Bojułko
Teresa
T
Kaczmarczyk
Mariusz
M
Sulzyc-Bielicka
Violetta
V
Bielicki
Dariusz
D
D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology; D000236:Adenoma / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D003106:Colon / Q000201:enzymology; D003111:Colonic Polyps / Q000201:enzymology* / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D042241:Early Diagnosis; D004848:Epithelium / Q000201:enzymology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D011044:Poland; D017154:Stromal Cells / Q000201:enzymology
D014408:Biomarkers, Tumor; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human