title: Double-blind, randomized, intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia.
abstract: BACKGROUND
  Tumescent local anesthesia (TLA) with lidocaine or prilocaine solutions is widely used in dermatology.
  
  
  OBJECTIVE
  Comparison of efficacy and safety of lidocaine and prilocaine in liposuctions with TLA.
  
  
  METHODS
  TLA was performed using defined dilutions of lidocaine or prilocaine. Half-side comparisons were applied on 26 patients undergoing symmetric liposuction. Pain reduction (overall sensation and pain at lancet prick) and tolerance were assessed before, during and 2-24 h after liposuction.
  
  
  RESULTS
  No differences in overall pain sensation between the substances were detected during and after liposuction except a more rapid onset with lidocaine (less pain after 15 min, p < 0.043). Local tolerance of both substances was excellent.
  
  
  CONCLUSIONS
  Lidocaine and prilocaine used in TLA for liposuction show good efficacy and tolerance. A fixed combination of lidocaine and prilocaine may reduce the risk of side effects when great quantities of TLA are needed.
authors.affiliation: Department of Dermatology, University Clinics of Hamburg, Hamburg, Germany. m.augustin@uke.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Augustin
authors.forename: Kristina
authors.initials: K
authors.lastname: Maier
authors.forename: Boris
authors.initials: B
authors.lastname: Sommer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sattler
authors.forename: Katharina
authors.initials: K
authors.lastname: Herberger
mesh_terms: D000328:Adult; D000772:Anesthesia, Local / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006615:Hip / Q000601:surgery; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use*; D015187:Lipectomy; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011318:Prilocaine / Q000009:adverse effects / Q000627:therapeutic use*; D013848:Thigh / Q000601:surgery
chemical_list: D011318:Prilocaine; D008012:Lidocaine