Too much of a good thing is bad: proteasome inhibition induces stressed hearts to fail.
Carrier
Lucie
L
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001897:Boronic Acids / Q000009:adverse effects / Q000494:pharmacology; D000069286:Bortezomib; D019703:Calcineurin / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D023421:Models, Animal; D032383:Myocytes, Cardiac / Q000502:physiology; D050778:NFATC Transcription Factors / Q000502:physiology; D011480:Protease Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000502:physiology*; D061988:Proteasome Inhibitors; D011719:Pyrazines / Q000009:adverse effects / Q000494:pharmacology; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology
D001897:Boronic Acids; D050778:NFATC Transcription Factors; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D011719:Pyrazines; D025801:Ubiquitin; D000069286:Bortezomib; D019703:Calcineurin; D046988:Proteasome Endopeptidase Complex