Morphology, growth, and size limit of bacterial cells.
Bacterial cells utilize a living peptidoglycan network (PG) to separate the cell interior from the surroundings. The shape of the cell is controlled by PG synthesis and cytoskeletal proteins that form bundles and filaments underneath the cell wall. The PG layer also resists turgor pressure and protects the cell from osmotic shock. We argue that mechanical influences alter the chemical equilibrium of the reversible PG assembly and determine the cell shape and cell size. Using a mechanochemical approach, we show that the cell shape can be regarded as a steady state of a growing network under the influence of turgor pressure and mechanical stress. Using simple elastic models, we predict the size of common spherical and rodlike bacteria. The influence of cytoskeletal bundles such as crescentin and MreB are discussed within the context of our model.
Jiang
Hongyuan
H
Department of Mechanical Engineering and Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Sun
Sean X
SX
D000255:Adenosine Triphosphate / Q000378:metabolism; D001419:Bacteria / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D048430:Cell Shape / Q000502:physiology; D002473:Cell Wall / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000737:chemistry; D003599:Cytoskeleton / Q000737:chemistry / Q000378:metabolism; D004926:Escherichia coli / Q000166:cytology / Q000254:growth & development / Q000378:metabolism / Q000648:ultrastructure; D010457:Peptidoglycan / Q000096:biosynthesis* / Q000737:chemistry; D013314:Stress, Mechanical; D013816:Thermodynamics
D003598:Cytoskeletal Proteins; D010457:Peptidoglycan; D000255:Adenosine Triphosphate