title: Serotonin syndrome in an orthopaedic patient secondary to linezolid therapy for MRSA infection.
abstract: A 67-year-old patient was admitted for incision and drainage of a recurrent methicillin-resistant Staphylococcus aureus (MRSA) hip abscess. Linezolid therapy was initiated postoperatively. Within 48 h the patient developed confusion, agitation, hypertension and acute renal failure. Citalopram was stopped and resolution of symptoms occurred within 48 h of discontinuing the offending agent. The symptoms observed in our patient were consistent with the Sternbach criteria for serotonin syndrome.
authors.affiliation: Mid-Western Regional Hospital, Dooradoyle, Limerick, Ireland. mcclean_mark@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: McClean
authors.forename: J C
authors.initials: JC
authors.lastname: Walsh
authors.forename: F
authors.initials: F
authors.lastname: Condon
mesh_terms: D000038:Abscess / Q000382:microbiology*; D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006621:Hip Joint / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D012008:Recurrence; D020230:Serotonin Syndrome / Q000139:chemically induced*; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid