Skeletal aging and the adipocyte program: New insights from an "old" molecule.
Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, time-keeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging.
Lecka-Czernik
Beata
B
Department of Orthopaedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, USA.
Rosen
Clifford J
CJ
Kawai
Masanobu
M
D017667:Adipocytes / Q000378:metabolism* / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D009687:Nuclear Proteins; D047495:PPAR gamma; D014157:Transcription Factors; C102804:nocturnin; D007334:Insulin-Like Growth Factor I