title: Weight of evidence approach for the relative hazard ranking of nanomaterials.
abstract: In assessing hazard for human health posed by newly engineered nanomaterials (ENM), approaches such as Weight of Evidence (WOE) and expert judgment are required to develop conclusions about the hazard of ENM. This is because all factors affecting hazard are not currently well defined and are often subject to different interpretation. Here we report the application of a WOE procedure to assess the potential of ENM to cause harm for human health, by integrating and combining physicochemical properties of NM and toxicity data obtained within the EU-funded Particle Risk project. The procedure was applied to carbon black (CB), single-walled carbon nanotubes (SWNT), C60 fullerene and quantum dots (QD) ENM tested during the Particle Risk project. The results show that some of the investigated ENM present a relatively higher hazardousness level on the basis of the integration of their physicochemical properties and toxicological effects, and that their hazard may be ranked as follow: QD >> C60 > SWNT > CB. This case study shows the utility of WOE approach to obtain a hazard ranking of ENM.
authors.affiliation: Venice Research Consortium, c/o VEGA - Venice Gateway for Science and Technology, Venice, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Zuin
authors.forename: Christian
authors.initials: C
authors.lastname: Micheletti
authors.forename: Andrea
authors.initials: A
authors.lastname: Critto
authors.forename: Giulio
authors.initials: G
authors.lastname: Pojana
authors.forename: Helinor
authors.initials: H
authors.lastname: Johnston
authors.forename: Vicki
authors.initials: V
authors.lastname: Stone
authors.forename: Lang
authors.initials: L
authors.lastname: Tran
authors.forename: Antonio
authors.initials: A
authors.lastname: Marcomini
mesh_terms: D004785:Environmental Pollutants / Q000633:toxicity; D037741:Fullerenes / Q000633:toxicity*; D015386:Hazardous Substances; D006801:Humans; D037742:Nanotubes, Carbon / Q000633:toxicity*; D045663:Quantum Dots; D012107:Research Design; D012307:Risk Factors; D053260:Soot / Q000633:toxicity*; D014116:Toxicology / Q000592:standards*
chemical_list: D004785:Environmental Pollutants; D037741:Fullerenes; D015386:Hazardous Substances; D037742:Nanotubes, Carbon; D053260:Soot