title: Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study.
abstract: F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults.
authors.affiliation: Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA. afiocco@klaru-baycrest.on.ca
authors.forename: A J
authors.initials: AJ
authors.lastname: Fiocco
authors.forename: A M
authors.initials: AM
authors.lastname: Kanaya
authors.forename: K M
authors.initials: KM
authors.lastname: Lindquist
authors.forename: T B
authors.initials: TB
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Satterfield
authors.forename: E M
authors.initials: EM
authors.lastname: Simonsick
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: C
authors.initials: C
authors.lastname: Rosano
authors.forename: K
authors.initials: K
authors.lastname: Yaffe
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003071:Cognition; D015331:Cohort Studies; D003704:Dementia / Q000378:metabolism / Q000523:psychology; D056344:Executive Function; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes