The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.
Hollenhorst
Marie A
MA
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Bumpus
Stefanie B
SB
Matthews
Megan L
ML
Bollinger
J Martin
JM
Kelleher
Neil L
NL
Walsh
Christopher T
CT