title: Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
authors.affiliation: Department of Chemistry, Kalypsys, Inc, 10420 Wateridge Circle, San Diego, California 92121, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Payne
authors.forename: Céline
authors.initials: C
authors.lastname: Bonnefous
authors.forename: Kent T
authors.initials: KT
authors.lastname: Symons
authors.forename: Phan M
authors.initials: PM
authors.lastname: Nguyen
authors.forename: Marciano
authors.initials: M
authors.lastname: Sablad
authors.forename: Natasha
authors.initials: N
authors.lastname: Rozenkrants
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Nahid
authors.initials: N
authors.lastname: Yazdani
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Shiau
authors.forename: Stewart A
authors.initials: SA
authors.lastname: Noble
authors.forename: Peter
authors.initials: P
authors.lastname: Rix
authors.forename: Tadimeti S
authors.initials: TS
authors.lastname: Rao
authors.forename: Christian A
authors.initials: CA
authors.lastname: Hassig
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Smith