Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Pacchiano
Fabio
F
Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Box 100245, Gainesville, Florida 32610, USA.
Aggarwal
Mayank
M
Avvaru
Balendu Sankara
BS
Robbins
Arthur H
AH
Scozzafava
Andrea
A
McKenna
Robert
R
Supuran
Claudiu T
CT