Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
Payne
Joseph E
JE
Department of Chemistry, Kalypsys, Inc, 10420 Wateridge Circle, San Diego, California 92121, USA.
Bonnefous
Céline
C
Symons
Kent T
KT
Nguyen
Phan M
PM
Sablad
Marciano
M
Rozenkrants
Natasha
N
Zhang
Yan
Y
Wang
Li
L
Yazdani
Nahid
N
Shiau
Andrew K
AK
Noble
Stewart A
SA
Rix
Peter
P
Rao
Tadimeti S
TS
Hassig
Christian A
CA
Smith
Nicholas D
ND