Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
He
Shuwen
S
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. shuwen_he@merck.com
Ye
Zhixiong
Z
Dobbelaar
Peter H
PH
Bakshi
Raman K
RK
Hong
Qingmei
Q
Dellureficio
James P
JP
Sebhat
Iyassu K
IK
Guo
Liangqin
L
Liu
Jian
J
Jian
Tianying
T
Lai
Yingjie
Y
Franklin
Christopher L
CL
Reibarkh
Mikhail
M
Holmes
Mark A
MA
Weinberg
David H
DH
MacNeil
Tanya
T
Tang
Rui
R
Tamvakopoulos
Constantin
C
Peng
Qianping
Q
Miller
Randy R
RR
Stearns
Ralph A
RA
Chen
Howard Y
HY
Chen
Airu S
AS
Strack
Alison M
AM
Fong
Tung M
TM
Wyvratt
Matthew J
MJ
Nargund
Ravi P
RP