Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.
Asagarasu
Akira
A
Synthetic Research Department, ASKA Pharmaceutical Co, Ltd, 5-36-1, Shimosakunobe, Takatsu-ku, Kawasaki 213-8522, Japan. asagarasu-a@aska-pharma.co.jp
Matsui
Teruaki
T
Hayashi
Hiroyuki
H
Tamaoki
Satoru
S
Yamauchi
Yukinao
Y
Minato
Kouichi
K
Sato
Michitaka
M