The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growth.
Zaldívar-Machorro
Víctor J
VJ
Departamento de Bioquímica, Facultad de Química, Universidad Nacional Autónoma de México, México D. F. 04510, México.
López-Ortiz
Manuel
M
Demare
Patricia
P
Regla
Ignacio
I
Muñoz-Clares
Rosario A
RA