Health-related quality of life in children with achalasia.
OBJECTIVE
To assess self-reported QoL in children with achalasia aged 5-18 and compare this with both disease and healthy control children in a prospective study.


METHODS
All children diagnosed with achalasia at one hospital were asked to participate in this study by completing the self-report module of the validated PedsQL™ generic QoL assessment. All children attending a tertiary paediatric gastroenterology clinic from February 2009 to May 2009 with chronic constipation or inflammatory bowel disease were asked to participate in this study as disease controls. The PedsQL™ considers physical, emotional, social and school domains and is scored from 0-100. Healthy children were also recruited from the same site. Groups were compared using Analysis of Variance with Tukey's post-hoc test.


RESULTS
One hundred and sixty one children completed the assessment (90 (56%) male, mean age 11.3 yrs ± 3.4 years) including 17 children with achalasia, 44 with chronic constipation, 59 with inflammatory bowel disease and 41 healthy children. QoL was significantly lower in the achalasia group compared to both children with IBD (73 vs. 82, p = 0.035) and healthy children (73 vs. 84, p = 0.005), and was comparable to that of children with chronic constipation (73 vs. 74, p = 0.99).


CONCLUSIONS
Children with achalasia report a significantly lower QoL compared to children with inflammatory bowel disease and healthy children.
Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, London, UK. mm1305@ic.ac.uk
Matko
M
Marlais
Julia R
JR
Fishman
John Me
JM
Fell
David J
DJ
Rawat
Munther J
MJ
Haddad
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003248:Constipation / Q000503:physiopathology / Q000523:psychology; D004931:Esophageal Achalasia / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology / Q000523:psychology; D008131:London; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D018434:Sickness Impact Profile