Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules.
An 8-(phenyl)-2'-deoxyguanosine derivative self-assembles in aqueous media into discrete hexadecamers that further self-assemble above 32 °C into microglobules that encapsulate the drug doxorubicin.
Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, PR 00931.
José E
JE
Betancourt
Chandramouleeswaran
C
Subramani
José L
JL
Serrano-Velez
Eduardo
E
Rosa-Molinar
Vincent M
VM
Rotello
José M
JM
Rivera
D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013696:Temperature
C110357:8-phenyl-2'-deoxyguanosine; D003839:Deoxyadenosines; D004337:Drug Carriers; D004317:Doxorubicin