[Embryonic genome organization after fertilization in mammals].
In mammals, the embryonic genome is first transcriptionally inactive after fertilization. Embryonic development is then strictly dependent on the maternally inherited RNA and proteins accumulated before ovulation and present in the oocyte cytoplasm. The onset of embryonic gene expression is initiated later during development, i.e. during the "embryonic genome activation (EGA)". EGA takes place at various preimplantation stages according to species and is dependent on the presence of the basal transcriptional machinery components but also on parental genomes reorganizations after fertilization. Indeed, during the first embryonic cycles, nuclei undergo intense remodeling that could be a key regulator of embryonic development.
Beaujean
Nathalie
N
INRA, UMR1198 Biologie du Développement et Reproduction, 78352 Jouy-en-Josas, France. nathalie.beaujean@jouy.inra.fr
Mason
Karlla
K
Bonnet-Garnier
Amélie
A
Salvaing
Juliette
J
Debey
Pascale
P
D000818:Animals; D001755:Blastocyst / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D015254:DNA Modification Methylases / Q000235:genetics; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D005306:Fertilization / Q000235:genetics / Q000502:physiology*; D014644:Genetic Variation; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D006657:Histones / Q000235:genetics; D008322:Mammals / Q000235:genetics* / Q000502:physiology*; D011247:Pregnancy; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D006657:Histones; D015254:DNA Modification Methylases; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase