Steroid receptor coactivator (SRC) family: masters of systems biology.
The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Since their discovery ∼15 years ago, the extraordinary sum of examination of SRC function has shaped the foundation of our knowledge for the now 350+ coregulators that have been identified to date. In this perspective, we retrace our steps into the field of coregulators and provide a summary of selected seminal work that helped define the SRCs as masters of systems biology.
York
Brian
B
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
O'Malley
Bert W
BW
D000818:Animals; D015706:Bibliometrics; D015415:Biomarkers; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000378:metabolism; D056920:Nuclear Receptor Coactivator 1 / Q000378:metabolism*; D051958:Nuclear Receptor Coactivator 2 / Q000378:metabolism*; D056921:Nuclear Receptor Coactivator 3 / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D049490:Systems Biology; D014158:Transcription, Genetic
D015415:Biomarkers; D008024:Ligands; D051958:Nuclear Receptor Coactivator 2; D018160:Receptors, Cytoplasmic and Nuclear; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3