Prognostic significance of CD151 expression in esophageal squamous cell carcinoma with aggressive cell proliferation and invasiveness.
BACKGROUND
CD151 is a member of the tetraspanins and has recently been reported as a promoter of the malignant progression of cancer. The purpose of this study was to clarify the clinicopathological outcome and prognostic significance of the immunohistochemical expression of CD151 in esophageal squamous cell carcinoma (ESCC).


METHODS
We evaluated the significance of CD151 expression by immunohistochemistry in 138 surgically resected ESCC and the association of CD151 expression with clinicopathological features.


RESULTS
Seventy-five (51.7%) ESCC showed a positive expression of CD151, which indicated a significant association with tumor depth (P = 0.004), lymph node metastasis (P = 0.002), distant metastasis (P = 0.025), and lymphatic invasion (P = 0.046), as well as the Ki-67 labeling index (P = 0.011). The 5-year survival rate of ESCC patients with CD151-positive expression was significantly lower than with CD151-negative expression (positive, 43.1%; negative, 63.8%; P = 0.003). Multivariate analysis showed that positive CD151 expression was not an independent factor for poor survival (P = 0.096).


CONCLUSIONS
CD151 expression is associated with tumor proliferation and invasiveness in ESCC.
Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan. suzukis@med.gunma-u.ac.jp
Shigemasa
S
Suzuki
Tatsuya
T
Miyazaki
Naritaka
N
Tanaka
Makoto
M
Sakai
Akihiko
A
Sano
Takanori
T
Inose
Makoto
M
Sohda
Masanobu
M
Nakajima
Hiroyuki
H
Kato
Hiroyuki
H
Kuwano
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D049109:Cell Proliferation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015996:Survival Rate; D060185:Tetraspanin 24
D015703:Antigens, CD; C554715:CD151 protein, human; D060185:Tetraspanin 24