Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease.
Sjogren
A-K M
AK
Andersson
K M E
KM
Khan
O
O
Olofsson
F J
FJ
Karlsson
C
C
Bergo
M O
MO
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D011905:Genes, ras; D051379:Mice; D009196:Myeloproliferative Disorders / Q000188:drug therapy* / Q000201:enzymology; D010641:Phenotype; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I