Natural products published in 2009 from plants traditionally used to treat malaria.
Malaria is a major parasitic disease and is responsible for almost one million deaths each year in Africa. There is an urgent need to discover new active compounds. Nature and particularly plants are a potential source of new antimalarial drugs since they contain a quantity of metabolites with a great variety of structures and pharmacological activities. This review covers the compounds with antiplasmodial activity isolated from plants which have been published during 2009 organized according to their phytochemical classes. Details are given for substances with IC₅₀ values ≤ 11 µM. Sixty-seven references are identified.
Bero
Joanne
J
Pharmacognosy Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium. Joanne.bero@uclouvain.be
Quetin-Leclercq
Joëlle
J
D000349:Africa; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D020128:Inhibitory Concentration 50; D008288:Malaria / Q000188:drug therapy*; D008519:Medicine, Traditional; D008517:Phytotherapy; D010944:Plants / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D001688:Biological Products