Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation.
The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.
Kritzik
Marcie R
MR
Department of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lago
Cory U
CU
Kayali
Ayse G
AG
Arnaud-Dabernat
Sandrine
S
Liu
Guoxun
G
Zhang
You-Qing
YQ
Hua
Hong
H
Fox
Howard S
HS
Sarvetnick
Nora E
NE
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D054377:Chemokine CXCL12 / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology* / Q000502:physiology*; D007422:Intestines / Q000166:cytology / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008822:Mice, Transgenic; D008938:Mitosis / Q000502:physiology; D008969:Molecular Sequence Data; D010179:Pancreas / Q000166:cytology* / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000378:metabolism; D012038:Regeneration / Q000502:physiology
C514936:CXCR4 protein, mouse; D054377:Chemokine CXCL12; C515256:Cxcl12 protein, mouse; D008565:Membrane Proteins; D019718:Receptors, CXCR4; C555527:epithelial progenitor 1 protein, mouse