Radiofrequency ablation for recurrent intrahepatic cholangiocarcinoma after curative resection.
OBJECTIVE
Percutaneous radiofrequency ablation (RFA) has shown efficacy in patients with recurrent hepatocellular carcinoma, but has not been well documented in patients with recurrent intrahepatic cholangiocarcinoma (ICC). We therefore evaluated the long-term survival and safety of percutaneous RFA for patients with recurrent ICC after curative resection.


METHODS
A total of 20 patients with 29 recurrent ICCs underwent ultrasound-guided percutaneous RFA. All patients had undergone curative resection of the primary ICC. Tumor size ranged from 0.7 cm to 4.4 cm in maximum dimension (mean, 1.9 cm; median, 1.5 cm).


RESULTS
The technical effectiveness rate of RFA was 97% (28/29) of recurrent ICCs. Mean local tumor progression-free survival was 39.8 months, and the cumulative local tumor progression-free 6 month and 1, 2, and 4 year survival rates were 93%, 74%, 74%, and 74%, respectively. Median overall survival after RFA was 27.4 months and the cumulative overall 6 month and 1, 2, and 4 year survival rates were 95%, 70%, 60%, and 21%, respectively. There were two major complications (one liver abscess and one biliary stricture, 7% per treatment) during the follow-up, but no procedure-related deaths.


CONCLUSIONS
RFA is safe and provides successful local tumor control in patients with recurrent ICC after curative resection. RFA for recurrent ICC resulted in a median overall survival rate of 27.4 months after RFA in the present series.
Radiology and Research Institute of Radiology, Asan Medical Center, Department of Surgery, University of Ulsan College of Medicine, Seoul, Republic of Korea. jhkimrad@amc.seoul.kr
Jin Hyoung
JH
Kim
Hyung Jin
HJ
Won
Yong Moon
YM
Shin
Pyo Nyun
PN
Kim
Sung-Gyu
SG
Lee
Shin
S
Hwang
D000328:Adult; D000368:Aged; D017115:Catheter Ablation / Q000401:mortality*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000401:mortality; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000601:surgery*; D015995:Prevalence; D025321:Surgery, Computer-Assisted / Q000706:statistics & numerical data; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D014463:Ultrasonography / Q000706:statistics & numerical data