Effect of iron and zinc deficiency on short term memory in children.
OBJECTIVE
To evaluate the effect of iron and zinc deficiency on short term memory of children in the age group of 6-11 years and to assess the response to supplementation therapy.


METHODS
Interventional study.


METHODS
100 children in the age group of 6-11 years (subdivided into 6-8 yr and 9-11 yr groups) from an urban corporation school.


METHODS
After collection of demographic data, the study children underwent hematological assessment which included serum iron, serum zinc, and hemoglobin estimation. Based on the results, they were divided into Iron deficient, Zinc deficient, and Combined deficiency groups. Verbal and nonverbal memory assessment was done in all the children.


METHODS
Iron (2mg/kg bodyweight in two divided doses) and zinc (5mg once-a-day) supplementation for a period of 3 months for children in the deficient group.


RESULTS
All children with iron and zinc deficiency in both the age groups had memory deficits. Combined deficiency in 9-11 years group showed severe degree of affectation in verbal (P<0.01) and non-verbal memory (P<0.01), and improved after supplementation (P = 0.05 and P< 0.01, respectively). In 6-8 years group, only non-verbal form of memory (P =0.02) was affected, which improved after supplementation.


CONCLUSIONS
Iron and zinc deficiency is associated with memory deficits in children. There is a marked improvement in memory after supplementation. Post supplementation IQ scores do not show significant improvement in deficient groups in 6-8 year olds.
Umamaheswari
K
K
Department of Physiology, Madras Medical College, Chennai, India. umamaheswari.g@hotmail.com
Bhaskaran
Mythily
M
Krishnamurthy
Gautham
G
Vasudevan
Hemamalini
H
Vasudevan
Kavita
K
D002648:Child; D015331:Cohort Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007194:India; D007501:Iron / Q000008:administration & dosage / Q000097:blood; D000090463:Iron Deficiencies; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D009483:Neuropsychological Tests; D013334:Students; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency*
D007501:Iron; D015032:Zinc