Effects of gallic acid on brain lipid peroxide and lipid metabolism in streptozotocin-induced diabetic Wistar rats.
This study evaluated the protective effects of gallic acid on brain lipid peroxidation products, antioxidant system, and lipids in streptozotocin-induced type II diabetes mellitus. Streptozotocin-induced diabetic rats showed a significant increase in the levels of blood glucose, brain lipid peroxidation products, and lipids and a significant decrease in the activities of brain enzymic antioxidants. Oral treatment with gallic acid (10 mg and 20 mg/kg) for 21 days significantly decreased the levels of blood glucose, brain lipid peroxidation products, and lipids and significantly increased the activities of brain enzymic antioxidants in diabetic rats. Histopathology of brain confirmed the protective effects of gallic acid. Furthermore, in vitro study revealed the free radical scavenging action of gallic acid. Thus, our study shows the beneficial effects of gallic acid on brain metabolism in streptozotocin-induced type II diabetic rats. A diet containing gallic acid may be beneficial to type II diabetic patients.
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar 608 002, India. ps_mainzenprince@yahoo.co.in
P
P
Stanely Mainzen Prince
M R
MR
Kumar
C J
CJ
Selvakumari
D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D005707:Gallic Acid / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D010851:Picrates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000633:toxicity; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D001713:Biphenyl Compounds; D001786:Blood Glucose; D008054:Lipid Peroxides; D008055:Lipids; D010851:Picrates; D017392:Thiobarbituric Acid Reactive Substances; D013311:Streptozocin; D005707:Gallic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl