Metastatic medullary carcinoma of the vulva in a patient with MEN IIb syndrome.
BACKGROUND
Multiple endocrine neoplasia (MEN) IIb is a rare genetic syndrome characterized by the occurrence of medullary thyroid carcinoma (MTC), pheochromocytoma and mucosal neuromas.


METHODS
A 43-year-old woman with MEN IIb syndrome presented to our department with a painful enlargement of the left side of her vulva, which was initially presumed to be an inflammatory Bartholin's gland process. Upon admission, the patient was on antibiotics with no response and surgery was decided. A wide local excision was performed and histology revealed a metastatic medullary carcinoma of the vulva.


CONCLUSIONS
MEN IIb syndrome is a clinical entity that may present multiple metastatic sites. To our knowledge, this is the first case of vulvar metastasis as part of the syndrome.
Thomakos
N
N
1st Department of Obstetrics and Gynecology, Alexandra Hospital, University of Athens, Athens, Greece.
Rodolakis
A
A
Akrivos
N
N
Skampardonis
N
N
Sotiropoulou
M
M
Biliatis
I
I
Alevizaki
M
M
Antsaklis
A
A
D000328:Adult; D018276:Carcinoma, Medullary / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D018814:Multiple Endocrine Neoplasia Type 2b / Q000556:secondary* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000556:secondary* / Q000601:surgery