Frequency of cognitive impairment dramatically increases during the first 5 years of multiple sclerosis.
Previous studies have demonstrated that cognitive impairment is already present in patients suffering from a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). However, little is known about the course of cognitive impairment after the occurrence of a CIS. In order to characterise the early evolution of cognitive impairment, the authors assessed during a 5-year follow-up period a group of 24 CIS patients with high risk of developing MS. Longitudinal neuropsychological assessment was performed at two time points (baseline and year 5) in patients and controls (baseline and year 1). At year 5, 54% of patients showed cognitive impairment against 29% at baseline. Multiple regression models showed that patients with a higher T(2) lesion load at baseline had a higher cognitive impairment at year 5. This longitudinal study performed in CIS patients showed that the frequency of cognitive impairment increases dramatically during the first 5 years following a CIS and that the cognitive status at year 5 was predictable by conventional MRI parameters recorded at baseline.
Pôle de Neurosciences cliniques, Service de Neurologie, Assistance publique Hôpitaux de Marseille, CHU Timone, Marseille, France. francoise.reuter@univmed.fr
Françoise
F
Reuter
Wafaa
W
Zaaraoui
Lydie
L
Crespy
Anthony
A
Faivre
Audrey
A
Rico
Irina
I
Malikova
Elisabeth
E
Soulier
Patrick
P
Viout
Jean-Philippe
JP
Ranjeva
Jean
J
Pelletier
Bertrand
B
Audoin
D000328:Adult; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000453:epidemiology*; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D009483:Neuropsychological Tests; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid; D012307:Risk Factors; D013116:Spinal Cord / Q000473:pathology
D043025:Oligoclonal Bands