Treatment and diagnosis of a dog with fulminant neurological deterioration due to anatoxin--a intoxication.
OBJECTIVE
To describe the clinical features, treatment, diagnostic work-up, and outcome of a dog with acute neurologic signs subsequent to algal toxin exposure.


METHODS
A Golden Retriever was presented for evaluation of acute onset of paraparesis after swimming in a man-made pond in early June and ingesting algae from a nearby bucket. The dog was anxious, had mild ptyalism, and when excited, developed generalized self-limiting tremors that progressed to generalized fasciculations and lateral recumbency. The dog was treated with activated charcoal and crystalloid fluids. Two hours after the presentation, the dog acutely decompensated and was ultimately euthanized. Gastric contents, bucket contents, pond water, bile, and urine were positive for anatoxin-a.


CONCLUSIONS
Anatoxin-a intoxication is rarely confirmed in dogs but should be considered as a differential diagnosis in any dog with acute neurologic signs. We report the first successful detection of anatoxin-a in urine and bile of a dog exposed to blue green algae. This new test provides an enhanced diagnostic tool in suspect cases and has possible therapeutic implications in dogs.
Puschner
Birgit
B
California Animal Health and Food Safety Laboratory System - Toxicology Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. bpuschner@ucdavis.edu
Pratt
Chap
C
Tor
Elizabeth R
ER
D000818:Animals; D000458:Cyanobacteria / Q000378:metabolism*; D000087522:Cyanobacteria Toxins; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004781:Environmental Exposure; D008297:Male; D014326:Tropanes / Q000378:metabolism / Q000506:poisoning*
D000087522:Cyanobacteria Toxins; D014326:Tropanes; C509783:anatoxin a