[Advancement of methanol poisoning mechanism research].
The methanol poisoning by oral intake or skin contact occurs occasionally, which may have serious consequences including blindness and/or death. Methanol and its metabolites, formaldehyde and formic acid, are associated with metabolic acidosis, visual dysfunction and neurological symptoms. At present, the mechanism of methanol poisoning primarily focuses on the cell hypoxia, the alteration of structure and biological activity induced by free radical and lactic acid. Meanwhile, methanol poisoning causes changes in the balance between the production of free radicals and antioxidant capacity and in the proteases-protease inhibitors system, which lead to a series of disturbances.
Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Jie-min
JM
Chen
Li-xin
LX
Wang
Wen-tao
WT
Xia
D000138:Acidosis / Q000139:chemically induced*; D000818:Animals; D005557:Formaldehyde / Q000378:metabolism / Q000506:poisoning*; D005561:Formates / Q000378:metabolism / Q000506:poisoning*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D000432:Methanol / Q000378:metabolism* / Q000506:poisoning*; D009420:Nervous System / Q000187:drug effects / Q000473:pathology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D014786:Vision Disorders / Q000139:chemically induced / Q000473:pathology; D000099295:Formyltetrahydrofolate Dehydrogenase
D005557:Formaldehyde; D005561:Formates; D005609:Free Radicals; D000432:Methanol; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011506:Proteins; D000099295:Formyltetrahydrofolate Dehydrogenase