Effects of early weaning on the circadian rhythm and behavioral satiety sequence in rats.
The objective of this work was to study the effect of early weaning on circadian rhythm and the behavioral satiety sequence in adult rats. Male Wistar rat pups were weaned for separation from the mother at 15 (D15), 21 (D21) and 30 (D30) days old. Body weight and food intake was measured every 30 days until pups were 150 days old. At 90 days of age, the circadian rhythm of food intake was evaluated every 4h for three days. Behavioral satiety was evaluated at 35 and 100 days of age. This work demonstrated that body weight and food intake were not altered, but the behavioral satiety sequence demonstrated that the D15 group delayed satiety compared with the D30 group at 100 days of age. In the circadian rhythm of the food intake study, early weaning (D15) changed food intake in the intermediary period of the light phase and in the intermediary period of the dark phase. In conclusion, our study showed that early weaning may alter the feeding behavior mainly in relation to satiety and the circadian rhythm of feeding. It is possible that the presence of other environmental stimuli during early weaning can cause hyperphagia and deregulate the mechanisms of homeostasis and body weight control. This study supports theories that depict insults during early life as determinants of chronic diseases.
Oliveira
Lisiane dos Santos
Ldos S
Centro Acadêmico de Vitória - Universidade Federal de Pernambuco, Vitória de Santo Antão - PE, Brazil. lisianenutricao@yahoo.com.br
da Silva
Ligia Pereira
LP
da Silva
Aline Isabel
AI
Magalhães
Carolina Peixoto
CP
de Souza
Sandra Lopes
SL
de Castro
Raul Manhães
RM
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004435:Eating / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012528:Satiety Response / Q000502:physiology*; D014886:Weaning