A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma--a case report with EGFR copy number analysis.
BACKGROUND
Small cell neuroendocrine carcinoma (SNEC) of maxillary sinus is a rare and aggressive malignancy. A tumor with squamous cell carcinoma, adenocarcinoma and SNEC co-existence is extremely rare.


METHODS
We present a colliding tumor of squamous cell, adenocarcinoma and SNEC in maxillary sinus. The clinical features, diagnosis and EGFR flourescence in situ hybridization (FISH) study are presented. A 52-year-old female had a 1-month history of progressing left cheek swelling and purulent rhinorrhea. Magnetic resonance imaging showed a tumor involving left maxilla and orbital floor. Excision of tumor was done and the defect was reconstructed with free flap. The pathology revealed a malignant tumor composed of squamous cell carcinoma, adenocarcinoma and SNEC components. EGFR FISH study showed no gene amplification in 3 components of this tumor. The tumor progressed rapidly and the patient expired at 8 months after surgery.


CONCLUSIONS
A colliding tumor of squamous cell, adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor.
Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan. bigmac@adm.cgmh.org.tww
Shiang-Fu
SF
Huang
Wen-Yu
WY
Chuang
Sou-De
SD
Cheng
Li-Jen
LJ
Hsin
Li-Yu
LY
Lee
Huang-Kai
HK
Kao
D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged
D004273:DNA, Neoplasm; D066246:ErbB Receptors