[Application of lamotrigine in bipolar disorder--3T MR spectroscopy follow up (part 1)].
MR spectroscopy (MRS) is a widely used and useful additional tool in the diagnostic process of several neuropsychiatric disorders. Despite several MRS studies in bipolar spectrum research, establishing a clean image about special metabolite alterations in the disorder still needs further investigation. The first part of this case study presents a bipolar II patient and her first 3T MR spectroscopy in drug-naive conditions, comparing to a healthy subject. Having finished the first MRS investigation, we applied lamotrigine medication. The ongoing second part of the study will show the data of the second MRS scan, after 5 month of lamotrigine therapy.
Vas Megyei Markusovszky Kórház Nonprofit Zrt., Pszichiátriai Centrum, Hungary.
Andras
A
Sumegi
Szabolcs
S
Halasz
Edit
E
Kliment
D018692:Antimanic Agents / Q000627:therapeutic use*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D000077213:Lamotrigine; D009682:Magnetic Resonance Spectroscopy; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*; D055815:Young Adult
D018692:Antimanic Agents; D018691:Excitatory Amino Acid Antagonists; D014227:Triazines; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline; D000077213:Lamotrigine