Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.
Eisele
Yvonne S
YS
Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.
Obermüller
Ulrike
U
Heilbronner
Götz
G
Baumann
Frank
F
Kaeser
Stephan A
SA
Wolburg
Hartwig
H
Walker
Lary C
LC
Staufenbiel
Matthias
M
Heikenwalder
Mathias
M
Jucker
Mathias
M
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D001923:Brain Chemistry; D016657:Cerebral Amyloid Angiopathy / Q000378:metabolism / Q000473:pathology; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000473:pathology; D011328:Prions / Q000737:chemistry / Q000378:metabolism; D017510:Protein Folding; D013997:Time Factors
D016229:Amyloid beta-Peptides; D011328:Prions