[Effects of pulsed magnetic field on insulin-like growth factor-1 (IGF-1) in cerebrospinal fluid and effects of IGF-1 on functional recovery].
OBJECTIVE
To study the effects of pulsed magnetic field on insulin-like growth factor-1 (IGF-1) level in the cerebrospinal fluid (CSF) and the association of IGF-1 alterations with the activities of daily living (ADL) of patients with brain injury.


METHODS
Sixty-five patients with brain injury were divided randomly into the control group (n=30) and magnetic therapy group (n=35), both receiving conventional therapy and in the latter group, daily pulsed magnetic field treatment (20-40 mT, 50 Hz, 20 min per time, 1 time per day) for 14 consecutive days were administered. On the first and 14th days of the treatment, 2 ml CSF was collected from the cases patients for IGF-1 measurement by radioimmunoassay, and Barthel index (BI) was used to assess the ADL of the patients.


RESULTS
After a 14-day treatment, IGF-1 level in the CSF were significantly increased in the magnetic group in comparison with the level before the treatment and with those in the control group (P<0.05). IGF-1 in the CSF underwent no significant changes in the control group (P>0.05). The scores of BI increased significantly in both groups after the treatment (P<0.01), but the increment was more obvious in the magnetic therapy group (P<0.05). A significant positive correlation was found between IGF-1 level in the CSF and BI in these patients (r=0.283, P=0.022).


CONCLUSIONS
Pulsed magnetic field might increase IGF-1 level in the CSF of patients with brain injury to promote the recovery of the patients ADL, suggesting its potential clinical value in the treatment of brain injury.
Song
Cheng-xian
CX
Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. songchengxian21@163.com
Fan
Jian-zhong
JZ
Wu
Hong-ying
HY
Wei
Yi
Y
Zhen
Jian-rong
JR
D000328:Adult; D001930:Brain Injuries / Q000134:cerebrospinal fluid* / Q000534:rehabilitation / Q000628:therapy*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000134:cerebrospinal fluid*; D060526:Magnetic Fields; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function
D007334:Insulin-Like Growth Factor I