Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice.
OBJECTIVE
The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy.


METHODS
Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administered intraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperature threshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifest diabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatment group (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8-476.7 mT peak-to-peak magnetic flux density.


RESULTS
Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statistically significantly (p < 0.001) reduced blood glucose level in the 200 mg/kg STZ (n = 6) group.


CONCLUSIONS
Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.
László
János F
JF
Institute for Research Organisation, Hungarian Academy of Sciences, Budapest, Hungary. laszlo.janos@office.mta.hu
Szilvási
Judit
J
Fényi
Anett
A
Szalai
Andrea
A
Gyires
Klára
K
Pórszász
Róbert
R
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000473:pathology / Q000628:therapy*; D003929:Diabetic Neuropathies / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D055909:Magnetic Field Therapy / Q000295:instrumentation; D051379:Mice; D009437:Neuralgia / Q000503:physiopathology / Q000628:therapy; D010147:Pain Measurement
D001786:Blood Glucose