Developmental and environmental origins of breast cancer: DDT as a case study.
More than 20 studies of serum "DDT" and breast cancer have found little support for the hypothesis that exposure influences risk of breast cancer. However, studies share common limitations including the inability to account for exposure in early life when the breast may be most vulnerable and the inability to measure exposure to the primary components of commercial DDT. This paper (1) summarizes evidence regarding critical windows of exposure for breast cancer (2) summarizes lessons learned from initial efforts to study DDT and breast cancer (3) reviews evidence from the Child Health and Development Studies (CHDS) where exposure was measured in young women using blood samples obtained during active exposure, 1-3 days after delivery and (4) suggests approaches for human studies that might advance understanding of environmental stressors in the developmental origins of disease.
Cohn
Barbara A
BA
Child Health and Development Studies, The Public Health Institute, Berkeley, CA 94709, United States. bcohn@chdstudies.org
D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D002274:Carcinogens, Environmental / Q000009:adverse effects* / Q000032:analysis; D003634:DDT / Q000009:adverse effects* / Q000097:blood; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D002274:Carcinogens, Environmental; D003634:DDT