Myocardial hypertrophy induces carotid body hyperplasia.
The carotid bodies tend to enlarge after long-standing cardiopulmonary disease. Our objective was to investigate whether cardiac hypertrophy is associated with carotid body hyperplasia. Fifteen autopsy cases with combined left and right ventricular hypertrophy were examined and compared with two control groups (16 cases). The study involved a meticulous dissection of carotid bifurcations, thin serial sections, and morphometric analysis of carotid body volume and cell types (progenitor, dark, light, and sustentacular). There was a significant increase in sustentacular cells in all individuals with cardiac hypertrophy, which was not drug-induced, and accompanied by a similar increase in carotid body volume. Dark or light cell accumulation was detected focally and only in three instances. It appears that the generalized sustentacular cell hyperplasia is the result of long-standing hypoxia, while a superimposed focal prominence of dark or light cells may be proliferative or metaplastic in nature and attributed to short-term hypoxia.
Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, Greece.
Efthimios
E
Sivridis
Pavlos
P
Pavlidis
Aliki
A
Fiska
Dimitra
D
Pitsiava
Alexandra
A
Giatromanolaki
D000368:Aged; D000369:Aged, 80 and over; D002344:Carotid Body / Q000473:pathology*; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D006965:Hyperplasia / Q000209:etiology; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000473:pathology*; D017380:Hypertrophy, Right Ventricular / Q000473:pathology*; D000860:Hypoxia / Q000473:pathology; D008297:Male; D008853:Microscopy; D008875:Middle Aged