The genetics of child psychiatric disorders: focus on autism and Tourette syndrome.
Investigations into the genetics of child psychiatric disorders have finally begun to shed light on molecular and cellular mechanisms of psychopathology. The first strains of success in this notoriously difficult area of inquiry are the result of an increasingly sophisticated appreciation of the allelic architecture of common neuropsychiatric and neurodevelopmental disorders, the consolidation of large patient cohorts now beginning to reach sufficient size to power reliable studies, the emergence of genomic tools enabling comprehensive investigations of rare as well as common genetic variation, and advances in developmental neuroscience that are fueling the rapid translation of genetic findings.
State
Matthew W
MW
Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA. matthew.state@yale.edu
D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002665:Child Psychiatry; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D005879:Tourette Syndrome / Q000235:genetics*