G-protein-coupled receptor structure: what can we learn?
The first, long-awaited, structures of non-visual G-protein-coupled receptors have provided important insights into the process of ligand binding and receptor activation. Here I explore the technological advances that enabled the resolution of the crystal structures of the β(1)- and β(2)-adrenergic receptors, and review what we have learnt and what is still to be discovered.
Department of Cell Physiology and Pharmacology, University of Leicester, Hodgkin Building Lancaster Road Leicester LE1 9HN UK.
Andrew B
AB
Tobin