No link of serotonin 2C receptor editing to serotonin transporter genotype.
RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.
James J. Peters Veterans Affairs Medical Center, Bronx, New York, USA
Rebecca
R
Lyddon
Edwin
E
Cuppen
Vahram
V
Haroutunian
Larry J
LJ
Siever
Stella
S
Dracheva
D000818:Animals; D004195:Disease Models, Animal; D045604:Extracellular Fluid / Q000378:metabolism; D055786:Gene Knockout Techniques; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D017393:RNA Editing / Q000235:genetics*; D051381:Rats; D044405:Receptor, Serotonin, 5-HT2C / Q000172:deficiency / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D012703:Serotyping
D044405:Receptor, Serotonin, 5-HT2C; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin