Actin crosslinkers: repairing the sense of touch.
Cells use actin bundles infused with myosin to exert contractile forces on the extracellular environment. This active tension is essential for cellular mechanosensation. Now, the role of actin crosslinkers in stabilizing and repairing the actin bundles is coming into clearer view.
Johns Hopkins University, Department of Mechanical Engineering, Institute for NanoBioTechnology, and Physical Science for Oncology Center, Baltimore, MD 21218, USA. ssun@jhu.edu
Sean X
SX
Sun
Sam
S
Walcott
D000199:Actins / Q000378:metabolism / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology*; D022001:Focal Adhesions / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D009218:Myosins / Q000378:metabolism*; D022502:Stress Fibers / Q000378:metabolism / Q000502:physiology*
D000199:Actins; D009218:Myosins