3D polymer scaffold arrays.
We have developed a combinatorial platform for fabricating tissue scaffold arrays that can be used for screening cell-material interactions. Traditional research involves preparing samples one at a time for characterization and testing. Combinatorial and high-throughput (CHT) methods lower the cost of research by reducing the amount of time and material required for experiments by combining many samples into miniaturized specimens. In order to help accelerate biomaterials research, many new CHT methods have been developed for screening cell-material interactions where materials are presented to cells as a 2D film or surface. However, biomaterials are frequently used to fabricate 3D scaffolds, cells exist in vivo in a 3D environment and cells cultured in a 3D environment in vitro typically behave more physiologically than those cultured on a 2D surface. Thus, we have developed a platform for fabricating tissue scaffold libraries where biomaterials can be presented to cells in a 3D format.
Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD, USA.
Carl G
CG
Simon
Yanyin
Y
Yang
Shauna M
SM
Dorsey
Murugan
M
Ramalingam
Kaushik
K
Chatterjee
D000818:Animals; D002448:Cell Adhesion; D018929:Cell Culture Techniques / Q000295:instrumentation*; D002460:Cell Line; D049109:Cell Proliferation; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D054457:Tissue Scaffolds / Q000737:chemistry*
D011108:Polymers