Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity.
The biophysical and biological properties of unprecedented anti-HIV aptamers are presented. The most active aptamer (1L) shows a significant affinity to the HIV protein gp120.
Oliviero
Giorgia
G
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Napoli, Italy.
Amato
Jussara
J
Borbone
Nicola
N
D'Errico
Stefano
S
Galeone
Aldo
A
Mayol
Luciano
L
Haider
Shozeb
S
Olubiyi
Olujide
O
Hoorelbeke
Bart
B
Balzarini
Jan
J
Piccialli
Gennaro
G
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000494:pharmacology; D054856:G-Quadruplexes; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D009841:Oligonucleotides / Q000737:chemistry*
D019380:Anti-HIV Agents; D052157:Aptamers, Nucleotide; D015699:HIV Envelope Protein gp120; D009841:Oligonucleotides; C514793:gp120 protein, Human immunodeficiency virus 1