Discordance between fasting glucose-based and hemoglobin A1c-based diagnosis of diabetes mellitus in Koreans.
We analyzed data of 35,624 non-diabetic Koreans using fasting plasma glucose (FPG) criteria and HbA1c criteria in screening for diabetes. Among the 1,491 subjects newly diagnosed with diabetes, 473 (31.6%) met the FPG criteria only (≥7.0mmol/l), 350 (23.5%) met HbA1c criteria only (≥6.5%), and 668 (44.9%) met both criteria. The DM-by-HbA1c group had significantly older age, higher proportion of women, and lower hemoglobin concentration. The DM-by-FPG group had higher systolic and diastolic blood pressure, fasting serum insulin, and HOMA-IR. Further studies are needed to determine which of these criteria is superior in predicting the risks of long-term vascular complications of diabetes.
Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea.
Chul-Hee
CH
Kim
Hong-Kyu
HK
Kim
Sung-Jin
SJ
Bae
Joong-Yeol
JY
Park
Ki-Up
KU
Lee
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000740:Anemia / Q000150:complications / Q000453:epidemiology; D001786:Blood Glucose / Q000032:analysis*; D048909:Diabetes Complications / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011314:Preventive Health Services; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012727:Sex Characteristics; D055815:Young Adult
D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human