Evaluation of Assam Bora rice starch as plasma volume expander by polymer analysis.
Water soluble polysaccharides are currently finding increasing use as a basis material for plasma volume expander. In clinical setting it is desirable to have a precise knowledge of steric and chemical structure, since these affect the pharmacokinetics and pharmacology of plasma volume expander. Branch component of starch amylopectin is very similar in structure to glycogen, the reserve polysaccharide of animal and therefore is liable to be compatible with body tissue. The knowledge of weight average molecular mass, degree of branching, osmotic pressure and coil dimension are essential, since low molecular mass do not have desirable effect and large molar mass have undesirable effect. Assam Bora rice starch was characterized by polymer analysis for use as plasma volume expander. Characterization involves the determination of FTIR spectra, degree of branching by H1 NMR, osmotic pressure by internal measurement technique, establishment of Mark-Houwink relationship and determination of Molecular weight - viscosity relationship.
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, (Assam), India.
Ashokanshu
A
Bhattacharya
Sohail
S
Akhter
Sheikh
S
Shahnawaz
Abdul Wadood
AW
Siddiqui
Mohammad Zaki
MZ
Ahmad
D000687:Amylopectin / Q000737:chemistry; D006851:Hydrochloric Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008970:Molecular Weight; D012275:Oryza / Q000737:chemistry*; D009997:Osmotic Pressure; D010952:Plasma Substitutes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D014783:Viscosity
D010952:Plasma Substitutes; D013213:Starch; D000687:Amylopectin; D006851:Hydrochloric Acid