Overcoming obstacles to developing new analgesics.
Despite substantial investment by the pharmaceutical industry over several decades, there has been little progress in developing new, efficacious and safe analgesics. As a result, many large pharmaceutical companies are leaving the area of pain medication. Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging.
Woolf
Clifford J
CJ
Neurobiology Center and Program in Neurobiology, Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, USA. clifford.woolf@childrens.harvard.edu
D000700:Analgesics / Q000191:economics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D017277:Drug Approval; D055808:Drug Discovery; D006801:Humans; D040541:Marketing; D010330:Patents as Topic; D010820:Physicians; D015203:Reproducibility of Results
D000700:Analgesics