Creutzfeldt-Jakob disease presenting as bulbar palsy.
Creutzfeldt-Jakob disease (CJD) is a degenerative neurological disorder caused by a prion protein. The diagnosis may be challenging in unusual early presentations. A bulbar symptom as the initial complaint is a rare presentation for CJD, with only a few reports so far. These patients can be misdiagnosed with motor neuron disease or the Miller Fisher variant of Guillain-Barré syndrome. We describe a 69-year-old woman with CJD who presented with bulbar symptoms at the onset.
Department of Neurology, The University of Kansas Medical Center, Kansas City, Kansas, USA. mmittal2@kumc.edu
Manoj
M
Mittal
Nancy
N
Hammond
Kathrin
K
Husmann
Abhijit
A
Lele
Mamatha
M
Pasnoor
D000368:Aged; D001344:Autopsy; D001921:Brain / Q000473:pathology; D010244:Bulbar Palsy, Progressive / Q000175:diagnosis*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D003680:Deglutition Disorders / Q000209:etiology; D004401:Dysarthria / Q000209:etiology; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009207:Myoclonus / Q000209:etiology; D014459:Ulnar Nerve / Q000503:physiopathology