Commensal Escherichia coli isolate resistant to eight classes of antimicrobial agents in the United States.
To increase understanding of community-acquired resistance, stool samples from 477 nonhospitalized persons in Maryland and Michigan, from 2004 to 2008, were screened for ceftriaxone resistance. Seven (1.5%) yielded ceftriaxone-resistant Escherichia coli; one isolate was resistant to all eight antimicrobial classes routinely tested: aminoglycosides, β-lactam/β-lactamase inhibitor combinations, cephems, penicillins, folate pathway inhibitors, phenicols, quinolones, and tetracyclines. The extensively resistant isolate was from a 50-year-old woman who denied antimicrobial use, hospitalization, or international travel within 6 months. Meat (beef, chicken, and pork) and eggs were consumed within 1 month before stool collection. Further studies are warranted to understand potential sources, including the food supply, of resistant E. coli.
Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Enteric, Zoonotic, and Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. frf7@cdc.gov
Amy L
AL
Krueger
Jason
J
Folster
Felicita
F
Medalla
Kevin
K
Joyce
Mary Beth
MB
Perri
Laura
L
Johnson
Marcus
M
Zervos
Jean M
JM
Whichard
Ezra J
EJ
Barzilay
D000328:Adult; D000818:Animals; D002443:Ceftriaxone / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D005798:Genes, Bacterial; D019450:Genes, MDR; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids / Q000235:genetics / Q000302:isolation & purification; D011159:Population Surveillance; D011795:Surveys and Questionnaires; D014481:United States
D002443:Ceftriaxone