[Strong association between the NINJ2 gene polymorphism and the susceptibility of stroke in Chinese Han population in Fangshan district].
OBJECTIVE
To investigate the association between the NINJ2 gene rs11833579 polymorphism and stroke in Han Chinese population.


METHODS
This study was a population-based cross-sectional case-control study. Polymerase chain reaction-restriction fragment length polymorphism (RFLP) and sequencing were used for the detection of NINJ2 genotypes in 790 patients with stroke (679 ischemic stroke) which were Han Chinese population from Fangshan First Hospital and 811 controls which were healthy Han Chinese population without family history of stroke in Fangshan district rural area.


RESULTS
In rs11833579 locus of the NINJ2 gene, the frequencies of GG genotype and allele G were higher in ischemic stroke patients than that in controls (P<0.001). The frequency of allele G of the NINJ2 gene was higher in cerebral hemorrhage patients than that in controls (P=0.005). Genotype had little effect on the glucose, total cholesterol and triglyceride.


CONCLUSIONS
There is significant association between rs11833579 site polymorphism of the NINJ2 gene and risk for stroke in Han Chinese population from Fangshan district.
National Laboratory of Medical Molecular Biology, Institution of Basic Medical Science, Clinic Academy of Medical Science & Peking Union Medical College, Beijing 100005, China.
Kuo
K
Chen
Zhan-sen
ZS
Xiao
Shu-qin
SQ
Hou
Run-tian
RT
Zhao
Yue-feng
YF
Liu
Hui-dong
HD
Dou
Guang-ping
GP
Li
Xiao-ming
XM
Tao
Feng
F
Li
Wen-yu
WY
Zhou
Chang-chun
CC
Qiu
D000368:Aged; D016022:Case-Control Studies; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000235:genetics; D002544:Cerebral Infarction / Q000235:genetics; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020521:Stroke / Q000235:genetics*
D015816:Cell Adhesion Molecules, Neuronal; C504206:NINJ2 protein, human