Risk factors of Peyronie's disease. What does our clinical experience show?
BACKGROUND
Peyronie's disease (PD) is a localized fibrosis that affects the tunica albuginea of the penis. Its origin can be associated with coital penile trauma in men with autoimmune hypersensitivity and a presumed genetic predisposition.


OBJECTIVE
To identify clinical and traumatic risk factors in a patient population with PD, when compared to a control group.


METHODS
From November 2007 to March 2010, 317 patients sought medical attention for PD. As control group, 147 consecutive patients, who came for a prostate exam, were studied. Clinical, traumatic, and sexual history of these patients was gathered. Risks factors were considered only if they had been present before the onset of PD symptoms.


METHODS
The International Index of Erectile Function and the International Prostate Symptoms Score. A univariate logistic regression model (chi-square) (odds ratios [ORs] and 95% confidence intervals [CI]) was used to estimate the association of risk factors with PD; and the Student's t-test was implemented for age.


RESULTS
The mean age of patients with PD and control group was 56.7 and 58.8, respectively (P<0.923). The mean evolution time of the disease was 17.7 months (2-48). Erectile dysfunction (ED) and coital trauma constituted the only two independent risk factors for PD compared to the control group (P<0.05 and 0.002, respectively) with an OR of 1.5 (95% CI 1.0-2.3) and 2.69 (95% CI 1.41-5.21), respectively. Patients with ED and diabetes mellitus and with a mild-to-moderate ED also presented a higher predisposition (P=0.008 and 0.00001), with an OR of 3.64 (95% CI 1.33-10.79) and 5.58 (95% CI 3.03-10.42), respectively.


CONCLUSIONS
Erectile dysfunction and coital trauma have proven to be independent risk factors for the development of PD.
Casabé
Adolfo
A
Urology Division, Hospital Durand, Buenos Aires, Argentina. arcasabe@fibertel.com.ar
Bechara
Amado
A
Cheliz
Germán
G
De Bonis
Walter
W
Rey
Horacio
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003075:Coitus / Q000502:physiology; D048909:Diabetes Complications / Q000473:pathology / Q000503:physiopathology; D007172:Erectile Dysfunction / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000502:physiology; D010411:Penile Induration / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D010413:Penis / Q000473:pathology / Q000503:physiopathology; D011467:Prostate / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D012725:Sexual Behavior