All change: protein conformation and the ubiquitination reaction cascade.
The structures of enzymes that collectively modify proteins by covalent addition of ubiquitin-like protein moieties have provided significant insights into the regulatory pathways they compose and have highlighted the importance of protein flexibility for the mechanism and regulation of the ubiquitination reaction.
Riedinger
Christiane
C
Laboratory of Molecular Biophysics and Department of Biochemistry South Parks Road, Oxford OX1 3QU UK.
Endicott
Jane A
JA