Mouse models of global cerebral ischemia.
Use of rodent models of hippocampal neurodegeneration are recommended for use in studies to understand the pathophysiology and molecular mechanisms involved. This unit includes protocols for two-vessel occlusion, three-vessel occlusion, and permanent bilateral vertebral artery occlusion plus methods for histological techniques for preparation of brain tissue and analysis of hippocampal injury.
Panahian
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N
University of Rochester, Rochester, New York, USA.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D001488:Basilar Artery / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006624:Hippocampus / Q000098:blood supply / Q000503:physiopathology; D051379:Mice; D009410:Nerve Degeneration / Q000473:pathology*; D014711:Vertebral Artery / Q000473:pathology / Q000503:physiopathology