Commensal Escherichia coli isolate resistant to eight classes of antimicrobial agents in the United States.
To increase understanding of community-acquired resistance, stool samples from 477 nonhospitalized persons in Maryland and Michigan, from 2004 to 2008, were screened for ceftriaxone resistance. Seven (1.5%) yielded ceftriaxone-resistant Escherichia coli; one isolate was resistant to all eight antimicrobial classes routinely tested: aminoglycosides, β-lactam/β-lactamase inhibitor combinations, cephems, penicillins, folate pathway inhibitors, phenicols, quinolones, and tetracyclines. The extensively resistant isolate was from a 50-year-old woman who denied antimicrobial use, hospitalization, or international travel within 6 months. Meat (beef, chicken, and pork) and eggs were consumed within 1 month before stool collection. Further studies are warranted to understand potential sources, including the food supply, of resistant E. coli.
Krueger
Amy L
AL
Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Enteric, Zoonotic, and Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. frf7@cdc.gov
Folster
Jason
J
Medalla
Felicita
F
Joyce
Kevin
K
Perri
Mary Beth
MB
Johnson
Laura
L
Zervos
Marcus
M
Whichard
Jean M
JM
Barzilay
Ezra J
EJ
D000328:Adult; D000818:Animals; D002443:Ceftriaxone / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D005798:Genes, Bacterial; D019450:Genes, MDR; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids / Q000235:genetics / Q000302:isolation & purification; D011159:Population Surveillance; D011795:Surveys and Questionnaires; D014481:United States
D002443:Ceftriaxone