Hypersensitivity pneumonitis due to high-dose colistin aerosol therapy.
We report a case of hypersensitivity pneumonitis, possibly due to aerosolized colistin therapy for severe multi-resistant Gram-negative pneumonia. Microbiological eradication was achieved with colistin therapy, which was stopped after 12 days in view of rising eosinophilia and possible lung fibrosis. The eosinophil count started to normalize 3 days after stopping colistin therapy and the patient was eventually weaned to minimal ventilatory support.
Leong
K W
KW
Department of Anesthesia and Surgical Intensive Care Unit, Singapore General Hospital, Singapore.
Ong
S
S
Chee
H L
HL
Lee
W
W
Kwa
A L
AL
D000280:Administration, Inhalation; D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D003091:Colistin