Recent advances in mast cell clonality and anaphylaxis.
Clonal expansion of mast cells carrying the D816V c-kit mutation results in mastocytosis. Recent studies identified the presence of clonal mast cells carrying this mutation in patients with anaphylaxis without classic diagnostic findings of systemic mastocytosis.
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Brigham & Women's Hospital, Division of Rheumatology, Immunology & Allergy 1 Jimmy Fund Way, Smith Building, Room 626B, Boston, MA 02445 USA.