Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions.
Coating surfaces with N-alkylated polyethylenimines (PEIs), namely branched N,N-hexyl,methyl-PEI via covalent attachment to glass or linear N,N-dodecyl,methyl-PEI by physical deposition ("painting") onto polyethylene, enables the resultant materials to quickly and efficiently disinfect aqueous solutions of (non-enveloped) poliovirus and rotavirus.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Alyssa M
AM
Larson
Bryan B
BB
Hsu
Debabrata
D
Rautaray
Jayanta
J
Haldar
Jianzhu
J
Chen
Alexander M
AM
Klibanov
D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D050296:Microbial Viability / Q000187:drug effects*; D017955:Poliovirus / Q000187:drug effects*; D011073:Polyamines / Q000737:chemistry / Q000494:pharmacology*; D000071228:Polyelectrolytes; D012401:Rotavirus / Q000187:drug effects*; D038301:Virus Inactivation
D020099:Coated Materials, Biocompatible; D004202:Disinfectants; D011073:Polyamines; D000071228:Polyelectrolytes