Treatment of murine Fusarium verticillioides infection with liposomal amphotericin B plus terbinafine.
Using a murine model of disseminated infection by Fusarium verticillioides, the efficacy of liposomal amphotericin (L-AmB) B at 10mg/kg body weight once daily and terbinafine (TRB) at 150 mg/kg body weight twice daily, alone and in combination, was evaluated. The combination of L-AmB with TRB was the only treatment able to prolong survival and to reduce fungal loads in the spleen and kidneys of mice infected with either strain of F. verticillioides used. The results suggest that this combination may have a role in the treatment of F. verticillioides infection.
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
Mery
M
Ruíz-Cendoya
F Javier
FJ
Pastor
Javier
J
Capilla
Josep
J
Guarro
D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005670:Fusarium / Q000187:drug effects* / Q000302:isolation & purification; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D009281:Naphthalenes / Q000008:administration & dosage*; D013154:Spleen / Q000382:microbiology; D016019:Survival Analysis; D000077291:Terbinafine; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077291:Terbinafine