Combined patch containing salicylic acid and nicotinamide: role of drug interaction.
The aim of the present study was to formulate a combined patch containing salicylic (SA) acid and nicotinamide (NA), useful for the treatment of mild acne, and to verify their mutual effect on drug permeation and skin retention. The performance of the patch was tested in vitro in permeation experiments using pig ear skin as barrier. To better understand the data obtained from the film, permeation from solutions and isopropyl myristate/water partition coefficient were also determined. The results obtained in the present work suggest a mutual influence of NA and SA on their permeation across the skin from an innovative transdermal film. The partition coefficient obtained when the two molecules were simultaneously present was typically lower than the respective value obtained with NA and SA alone.
Dipartimento Farmaceutico, Università degli Studi di Parma, Viale G. P. Usberti 27/A, 43100 Parma, Italy.
Cristina
C
Padula
Chiara
C
Ferretti
Sara
S
Nicoli
Patrizia
P
Santi
D000279:Administration, Cutaneous; D000818:Animals; D020405:Dermis / Q000378:metabolism; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods; D004347:Drug Interactions / Q000502:physiology; D004817:Epidermis / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009226:Myristates / Q000737:chemistry; D009536:Niacinamide / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010539:Permeability / Q000187:drug effects; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology; D012995:Solubility; D013012:Sorbitol / Q000737:chemistry; D034421:Sus scrofa; D057968:Transdermal Patch; D014867:Water / Q000737:chemistry
D004338:Drug Combinations; D009226:Myristates; D014867:Water; C008205:isopropyl myristate; D009536:Niacinamide; D013012:Sorbitol; D011142:Polyvinyl Alcohol; D011205:Povidone; D020156:Salicylic Acid