Natural peroxisome proliferator-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis.
BACKGROUND
Atopic dermatitis (AD) requires permanent skin care.


OBJECTIVE
A cream containing 2% SO (sunflower oleodistillate), with peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist properties, has been compared to a topical steroid (hydrocortisone butyro-propionate 1 mg/g).


METHODS
An open, randomized study included two groups of 40 children (aged 3 months to 4 years). Group A applied the steroid and group B applied the 2% SO cream, twice a day. SCORAD (SCORing Atopic Dermatitis) was determined at D0, D7 and D21 and quality of life (QoL) at D0 and D21.


RESULTS
SCORAD was similar at D0 (37.2 versus 36.9), D7 (18.9 versus 19.2) (-49% and -48%) and D21 (11 versus 9.4) (-70% and -75%) (p < 0.01 versus D0). The Infant Dermatitis Quality of Life and Dermatitis Family Impact Questionnaire improved similarly by 65%/67% in group A and 72%/75% in group B at D21 (p < 0.01 versus D0).


CONCLUSIONS
A 2% SO cream has demonstrated therapeutic properties, using clinical scores and QoL, comparable to those of a topical steroid.
Department of Dermatology, Institut Alfred Fournier, Paris, France.
Clarence
C
De Belilovsky
Elia
E
Roo-Rodriguez
Caroline
C
Baudouin
Franck
F
Menu
Bernard
B
Chadoutaud
Philippe
P
Msika
D000287:Administration, Topical; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004643:Emollients; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D047493:PPAR alpha / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D011788:Quality of Life; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D004643:Emollients; D047493:PPAR alpha; D006854:Hydrocortisone