Isolated perfused porcine skin flap.
The isolated porcine skin flap is used to determine the rate and extent of absorption of chemicals through skin. This ex vivo model system allows cutaneous toxicology and pharmacology studies to be conducted in viable skin that has a normal structure and intact microvasculature. Porcine skin is also anatomically and physiologically similar to human skin, therefore data from studies using this ex vivo system can in some cases to predict dermatopharmacokinetics and dermotoxicity to test compounds in humans.
North Carolina State University, Raleigh, North Carolina, USA.
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Baynes
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion; D010600:Pharmacology / Q000295:instrumentation / Q000379:methods*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*; D012869:Skin Absorption; D013045:Species Specificity; D013524:Surgical Flaps; D013552:Swine; D014116:Toxicology / Q000295:instrumentation / Q000379:methods*