The microbicidal and cytoregulatory roles of NADPH oxidases.
Despite their prominent microbicidal roles, NADPH oxidases (NOXs) have been recently found to regulate a wide variety of physiological activities. Through generation of reactive oxygen species (ROS), NOXs actively participate in cellular activities, including NET formation, inflammasome activation and wound sensing. The microbicidal and cytoregulatory roles of NOXs are contrasted in this review.
Yang
Hung-Chi
HC
Department of Medical Biotechnology and Laboratory Sciences, Chang-Gung University, Kwei-san, Tao-Yuan, Taiwan.
Cheng
Mei-Ling
ML
Ho
Hung-Yao
HY
Chiu
Daniel Tsun-Yee
DT
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007239:Infections / Q000201:enzymology; D007249:Inflammation / Q000201:enzymology; D019255:NADPH Oxidases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D000890:Anti-Infective Agents; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases