Short communication: predicting adverse HIV-related outcomes in a resource-limited setting: use of the inflammation marker α(1)-acid glycoprotein.
Limited data exist on the use of acute-phase proteins as predictors of HIV-related outcomes. We examined the relationship between postpartum α(1)-acid glycoprotein (AGP) concentrations and HIV-related maternal mortality, mother-to-child transmission, and HIV-free survival among 643 Zimbabwean women. Elevated AGP was significantly associated with a 5.74-fold (p = 0.001) increased risk of maternal death, a 2.39-fold (p = 0.033) increased risk of postnatal transmission, and a marginally significant 1.85-fold (p = 0.087) increased risk of infant infection or death. In a resource-limited setting, AGP may be of utility as an inexpensive prognostic tool for HIV-infected individuals.
Rawat
Rahul
R
International Food Policy Research Institute , Poverty Health and Nutrition Division, Washington, DC, USA.
Humphrey
Jean H
JH
Mutasa
Kuda
K
Ntozini
Robert
R
Stoltzfus
Rebecca J
RJ
D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009961:Orosomucoid / Q000032:analysis*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000401:mortality*; D011379:Prognosis; D013534:Survival; D015030:Zimbabwe
D009961:Orosomucoid