Clitoral and vulvar vestibular sensation in women taking 20 mcg ethinyl estradiol combined oral contraceptives: a preliminary study.
BACKGROUND
Many women taking low-dose (20 mcg) oral contraceptive pills (OCPs) complain of decreased libido and arousal and some develop vulvar vestibular pain and dyspareunia. Free testosterone concentrations are decreased by the OCP. Genital sensation has not been objectively measured in women taking OCPs.


OBJECTIVE
We assessed whether the 20 mcg ethinyl estradiol combined OCP and associated decrease in free testosterone levels affected genital sensation in a pilot study of a group of asymptomatic OCP users and controls.


METHODS
Clitoral thermal, vibratory, and vestibular pain thresholds, sexual functioning, and free testosterone levels were measured in 24 women taking 20 mcg ethinyl estradiol combined OCPs and 28 comparison women not using hormonal contraception.


METHODS
Female Sexual Functioning Index (FSFI), free testosterone, and clitoral heat, cold, and vibratory thresholds for sensation and vestibular pain thresholds.


RESULTS
Free testosterone levels were lower in OCP users. There were no differences in FSFI scores, clitoral thermal or vibratory thresholds, or vestibular pain thresholds between groups.


CONCLUSIONS
Low-dose (20 mcg) oral contraceptives decrease free testosterone but are not associated with alterations in clitoral or vestibular sensation. Further studies of genital sensation in women with OCP-related sexual dysfunction are warranted.
Lee
Monica
M
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Group, Beverly Hills, CA, USA.
Morgan
Melinda
M
Rapkin
Andrea
A
D000328:Adult; D002140:California; D016022:Case-Control Studies; D002987:Clitoris / Q000187:drug effects*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004414:Dyspareunia / Q000139:chemically induced / Q000517:prevention & control; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D017288:Pain Threshold / Q000187:drug effects; D010865:Pilot Projects; D012725:Sexual Behavior / Q000187:drug effects; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000517:prevention & control; D013739:Testosterone / Q000097:blood; D013697:Thermosensing / Q000187:drug effects; D014110:Touch / Q000187:drug effects*; D014732:Vibration; D014844:Vulva / Q000187:drug effects*
D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D013739:Testosterone; D004997:Ethinyl Estradiol