Targeted renal therapies through microbubbles and ultrasound.
Microbubbles and ultrasound enhance the cellular uptake of drugs (including gene constructs) into the kidney. Microbubble induced modifications to the size selectivity of the filtration capacity of the kidney may enable drugs to enter previously inaccessible compartments of the kidney. So far, negative renal side-effects such as capillary bleeding have been reported only in rats, with no apparent damage in larger models such as pigs and rabbits. Although local delivery is accomplished by applying ultrasound only to the target area, efficient delivery using conventional microbubbles has depended on the combined injection of both drugs and microbubbles directly into the renal artery. Conjugation of antibodies to the shell of microbubbles allows for the specific accumulation of microbubbles in the target tissue after intravenous injection. This exciting approach opens new possibilities for both drug delivery and diagnostic ultrasound imaging in the kidney.
Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Netherlands. L.E.Deelman@med.umcg.nl
Leo E
LE
Deelman
Anne-Emilie
AE
Declèves
Joshua J
JJ
Rychak
Kumar
K
Sharma
D000818:Animals; D003287:Contrast Media; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D045423:Microbubbles; D011817:Rabbits; D051381:Rats; D013552:Swine; D014465:Ultrasonics
D003287:Contrast Media