Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach.
The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in α of the nitrogen has been performed through an inverse-demanding aza-Diels-Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.
De
Kavita
K
Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ Paris Sud, 5 rue J.B. Clément, F-92296 Châtenay-Malabry, France.
Legros
Julien
J
Crousse
Benoit
B
Chandrasekaran
Srinivasan
S
Bonnet-Delpon
Danièle
D
D000634:Aminoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D010618:Phenanthrolines / Q000138:chemical synthesis*
D000634:Aminoquinolines; D010618:Phenanthrolines; C080436:8-aminoquinoline