Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity.
While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, United States.
Amelia R
AR
Hofstetter
Lucy C
LC
Sullivan
Aron E
AE
Lukacher
Andrew G
AG
Brooks
D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D013601:T-Lymphocytes / Q000276:immunology
D015395:Histocompatibility Antigens Class I