Meta-analysis of passive immunoprophylaxis in paediatric patients at risk of severe RSV infection.
OBJECTIVE
To review respiratory syncytial virus (RSV), passive immunoprophylaxis (PI) trials and meta-analysis (MA).


METHODS
A literature review.


RESULTS
Two MA of PI were found. Overall 3927 patients were randomized. PI reduces RSV hospitalization in patients with bronchopulmonary dysplasia (RR 0.58; 95% CI 0.41, 0.82) and with acyanotic congenital heart disease (RR 0.29; 95% CI 0.14, 0.62). In patients with cyanotic heart disease or premature infants without bronchopulmonary dysplasia, results are inconclusive. Passive immunoprophylaxis has a null effect in mechanical ventilation and death.


CONCLUSIONS
Passive immunoprophylaxis reduces RSV hospitalization in a subset of patients. However, it has no effect in harder endpoints of RSV disease severity.
Pons
J M V
JM
Agència d'Avaluació de Tecnologia i Recerca Mèdiques (Catalan Agency for Health Technology Assessment and Research), Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. joan.ponsr@gencat.cat
Tebé
C
C
Paladio
N
N
Garcia-Altes
A
A
Danés
I
I
Valls-I-Soler
A
A
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007223:Infant; D016032:Randomized Controlled Trials as Topic; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control*; D018570:Risk Assessment; D012720:Severity of Illness Index
D000911:Antibodies, Monoclonal