Redefining the TGR5 triterpenoid binding pocket at the C-3 position.
Genet
Cédric
C
UMR/CNRS, Université de Strasbourg, Illkirch, France.
Schmidt
Céline
C
Strehle
Axelle
A
Schoonjans
Kristina
K
Auwerx
Johan
J
Saladin
Régis
R
Wagner
Alain
A
D001665:Binding Sites; D018360:Crystallography, X-Ray; D006801:Humans; D008968:Molecular Conformation; D053978:Pentacyclic Triterpenes; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000094062:Betulinic Acid
C473772:GPBAR1 protein, human; D053978:Pentacyclic Triterpenes; D043562:Receptors, G-Protein-Coupled; D014315:Triterpenes; D000094062:Betulinic Acid