A model for harmonizing flow cytometry in clinical trials.
Complexities in sample handling, instrument setup and data analysis are barriers to the effective use of flow cytometry to monitor immunological parameters in clinical trials. The novel use of a central laboratory may help mitigate these issues.
Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA. maecker@stanford.edu
Holden T
HT
Maecker
J Philip
JP
McCoy
Michael
M
Amos
John
J
Elliott
Adolfas
A
Gaigalas
Lili
L
Wang
Richard
R
Aranda
Jacques
J
Banchereau
Chris
C
Boshoff
Jonathan
J
Braun
Yael
Y
Korin
Elaine
E
Reed
Judy
J
Cho
David
D
Hafler
Mark
M
Davis
C Garrison
CG
Fathman
William
W
Robinson
Thomas
T
Denny
Kent
K
Weinhold
Bela
B
Desai
Betty
B
Diamond
Peter
P
Gregersen
Paola
P
Di Meglio
Paola
P
DiMeglio
Frank O
FO
Nestle
Frank
F
Nestle
Mark
M
Peakman
Federica
F
Villanova
Federica
F
Villnova
John
J
Ferbas
Elizabeth
E
Field
Aaron
A
Kantor
Thomas
T
Kawabata
Wendy
W
Komocsar
Michael
M
Lotze
Jerry
J
Nepom
Hans
H
Ochs
Raegan
R
O'Lone
Deborah
D
Phippard
Scott
S
Plevy
Stephen
S
Rich
Mario
M
Roederer
Dan
D
Rotrosen
Jung-Hua
JH
Yeh
D002986:Clinical Trials as Topic; D005434:Flow Cytometry / Q000379:methods* / Q000592:standards*; D006801:Humans; D013048:Specimen Handling