A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.
Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
Marti
Guillaume
G
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Eparvier
Véronique
V
Litaudon
Marc
M
Grellier
Philippe
P
Guéritte
Françoise
F
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
D000962:Antimalarials; D010936:Plant Extracts; D044004:Xanthones; C009689:xanthone