Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.
OBJECTIVE
Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.


METHODS
Polymorphisms were studied by allelic discrimination.


RESULTS
In a hospital-based case-control study on 500 individuals (235 cases and 265 controls) of Czech white origin, SOD2, SOD3, NQO1, and NQO2 polymorphisms showed no significant association with pancreatic cancer risk. Major lifestyle factors such as smoking and alcohol, coffee, or tea consumption did not modify the effect of the studied polymorphisms.


CONCLUSIONS
The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. Despite this observation, other populations with different lifestyle(s) may be at risk and should be further studied.
Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic.
Beatrice
B
Mohelnikova-Duchonova
Lenka
L
Marsakova
David
D
Vrana
Ivana
I
Holcatova
Miroslav
M
Ryska
Zdenek
Z
Smerhovsky
Alena
A
Slamova
Miriam
M
Schejbalova
Pavel
P
Soucek
D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011808:Quinone Reductases / Q000235:genetics*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C441642:SOD3 protein, human; C447479:NQO1 protein, human; C419642:NRH - quinone oxidoreductase2