Lacosamide and epilepsy.
We will review all available studies on the use of lacosamide in the treatment of partial-onset seizures. The available evidence includes two open-label studies and three randomized controlled trials evaluating the safety and efficacy of oral lacosamide. One open-label study and one randomized controlled trial evaluating the safety and tolerability of intravenous lacosamide was also identified. Lacosamide was found to be efficacious with significant reduction in seizure frequency dosed 400-600 mg daily. Moreover, its adverse drug effects were mild and infrequently reported in the literature. Findings suggest that lacosamide is an effective agent for adjunctive treatment of refractory partial-onset seizures.
Department of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO 63110-1088, USA. jharris2@stlcop.edu
Jacklyn A
JA
Harris
Julie A
JA
Murphy
D000081:Acetamides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000075202:Contraindications; D004828:Epilepsies, Partial / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D000078334:Lacosamide; D016032:Randomized Controlled Trials as Topic; D013226:Status Epilepticus / Q000188:drug therapy
D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide