What is the significance of soluble and endogenous secretory receptor for advanced glycation end products in liver steatosis in obese prepubertal children?
The endogenous secretory receptor for advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) have been shown in human plasma and have emerged as reliable biomarkers of several pathological conditions, including insulin resistance and liver injury. We examined esRAGE and sRAGE levels in obese prepubertal children with and without liver steatosis. esRAGE and sRAGE levels were significantly lower in obese prepubertal children affected by liver steatosis and were independently related to liver steatosis. These findings suggest that AGE-RAGE pathway plays an independent role in the development of liver injury already present in this age group.
Department of Pediatrics, University of Chieti, Chieti, Italy.
Ebe
E
D'Adamo
Cosimo
C
Giannini
Valentina
V
Chiavaroli
Tommaso
T
de Giorgis
Alberto
A
Verrotti
Francesco
F
Chiarelli
Angelika
A
Mohn
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005234:Fatty Liver / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D055815:Young Adult
D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic