Monitoring endocrine function in males: using intra-atrial cannulas to monitor plasma hormonal dynamics in toxicology experiments.
Intra-atrial cannulation provides assessment of endocrine change within animals. Protocols for permanent tethers used in short-term 5- to 10-day experiments and permanent vascular access used in long-term (>10 days) experiments are presented. A protocol for blood processing is also included. Data from a longitudinal endocrine baseline assessment (LEBA) and an endocrine challenge test (ECT) are presented as well.
Fail
Patricia A
PA
Research Triangle Institute, Research Triangle Park, North Carolina, USA.
Anderson
Stephanie A
SA
D000818:Animals; D002408:Catheters, Indwelling; D052244:Endocrine Disruptors / Q000633:toxicity*; D004703:Endocrine System / Q000187:drug effects*; D006325:Heart Atria; D006728:Hormones / Q000097:blood*; D008297:Male; D051381:Rats
D052244:Endocrine Disruptors; D006728:Hormones