[The influence of aromatic amino acid derivatives on the complement system under ionizing radiation].
Activities of the complement classical, alternative and lectin pathways were determined under conditions of X-radiation in the blood of rats treated and none-treated with synthetic Schiffbase aromatic amino acid derivatives, nicotinyl-L-tyrosinate or nicotinyl-L-tryptophanate, before irradiation. In case of activities of the alternative and lectin pathways no significant changes between irradiated animals and none-irradiated control animals were detected. However, the data obtained demonstrate significantly elevated activity of the classical complement cascade in the blood of irradiated animals (1 day after irradiation), as compared to those none-irradiated. This effect was less pronounced in rats treated with nicotinyl-L-tyrosinate or nicotinyl-L-tryptophanate 1 hour before irradiation. Based on the results obtained the ability of nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate to act as cyto-protectors is concluded.
A S
AS
Boiadzhian
E A
EA
Arakelova
G V
GV
Avetisian
M G
MG
Malakian
S A
SA
Badzhinian
D000818:Animals; D003170:Complement Pathway, Alternative / Q000528:radiation effects*; D003171:Complement Pathway, Classical / Q000528:radiation effects*; D037582:Complement Pathway, Mannose-Binding Lectin / Q000528:radiation effects*; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012545:Schiff Bases / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014364:Tryptophan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014965:X-Rays / Q000009:adverse effects
D009539:Nicotinic Acids; D011837:Radiation-Protective Agents; D012545:Schiff Bases; C555004:nicotinyl tryptophanate; C555003:nicotinyl tyrosinate; D014443:Tyrosine; D014364:Tryptophan