In search of blood tests for thoracic aortic diseases.
A number of new diagnostic screening tools have been developed for the assessment of acute and chronic diseases of the thoracic aorta. Although standardized blood-based tests capable of detecting individuals at risk for aortic aneurysm and dissection disease are not yet available, our current knowledge is expanding at a rapid rate and the future is very promising. In this review, an update of the contemporary knowledge on blood tests for detecting thoracic aortic diseases in both preclinical and clinical settings is provided, offering the potential to predict adverse aortic events, such as enlargement, rupture, and dissection.
Trimarchi
Santi
S
Policlinico San Donato IRCCS, Cardiovascular Center E. Malan, University of Milano, Milan, Italy. santi.trimarchi@grupposandonato.it
Sangiorgi
Giuseppe
G
Sang
Xiangpeng
X
Rampoldi
Vincenzo
V
Suzuki
Toru
T
Eagle
Kim A
KA
Elefteriades
John A
JA
D000209:Acute-Phase Proteins / Q000032:analysis; D000784:Aortic Dissection / Q000097:blood / Q000175:diagnosis*; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000175:diagnosis; D017545:Aortic Aneurysm, Thoracic / Q000097:blood / Q000175:diagnosis*; D002135:Calcium-Binding Proteins / Q000097:blood; D016207:Cytokines / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D020782:Matrix Metalloproteinases / Q000097:blood; D008840:Microfilament Proteins / Q000097:blood; D018995:Myosin Heavy Chains / Q000097:blood; D000096985:Calponins
D000209:Acute-Phase Proteins; D002135:Calcium-Binding Proteins; D016207:Cytokines; D005338:Fibrin Fibrinogen Degradation Products; D017228:Hepatocyte Growth Factor; D020782:Matrix Metalloproteinases; D008840:Microfilament Proteins; D018995:Myosin Heavy Chains; D000096985:Calponins; C036309:fibrin fragment D