Effect of pharmacist intervention on glycemic control in diabetes.
OBJECTIVE
To conduct a meta-analysis evaluating the effect of pharmacist intervention on glycemic control.


METHODS
A systematic search of Medline and CENTRAL was conducted from the earliest possible date through June 2010. Trials were included if they were randomized controlled trials in a diabetic population, evaluated any form of pharmacist intervention and reported data on hemoglobin A1C (A1C). A random-effects model was used to calculate weighted mean differences (WMDs) and 95% confidence intervals.


RESULTS
Fourteen trials (n = 2073) evaluating the effect of pharmacist intervention on glycemic control were identified. Pharmacist intervention significantly lowered A1C (n = 14 trials, WMD -0.76%, 95%CI -1.06 to -0.47) and fasting blood glucose (FBG) (n = 4 trials, WMD -29.32 mg/dL, 95%CI -39.54 to -19.10). A moderate to high degree of statistical heterogeneity was observed in these analyses (I(2) ≥ 44.1% for both).


CONCLUSIONS
Our findings demonstrate statistically and clinically significant associations between pharmacist intervention and improvement in glycemic control.
Collins
Courtney
C
University of Connecticut School of Pharmacy, Storrs, CT 06102-5037, United States.
Limone
Brendan L
BL
Scholle
Jennifer M
JM
Coleman
Craig I
CI
D000368:Aged; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010595:Pharmacists; D016032:Randomized Controlled Trials as Topic
D006442:Glycated Hemoglobin