The heme biosynthesis pathway and clinical manifestations of abnormal function.
Biosynthesis of heme is important for both prokaryotes and eukaryotes. The enzymes for this multistep process are distributed between the cytosol and mitochondria in eukaryotes. In humans there are inherited and acquired disorders characterized by over synthesis of one or more enzymes or absence of an enzyme. This overview discusses each enzyme in the heme biosynthesis pathway.
Phillips
J D
JD
University of Utah Medical School, Salt Lake City, Utah, USA.
Kushner
J P
JP
D006418:Heme / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D011164:Porphyrias / Q000201:enzymology / Q000378:metabolism*; D011166:Porphyrins / Q000652:urine
D011166:Porphyrins; D006418:Heme