Quantitative analysis of cellular metabolic dissipative, self-organized structures.
One of the most important goals of the postgenomic era is understanding the metabolic dynamic processes and the functional structures generated by them. Extensive studies during the last three decades have shown that the dissipative self-organization of the functional enzymatic associations, the catalytic reactions produced during the metabolite channeling, the microcompartmentalization of these metabolic processes and the emergence of dissipative networks are the fundamental elements of the dynamical organization of cell metabolism. Here we present an overview of how mathematical models can be used to address the properties of dissipative metabolic structures at different organizational levels, both for individual enzymatic associations and for enzymatic networks. Recent analyses performed with dissipative metabolic networks have shown that unicellular organisms display a singular global enzymatic structure common to all living cellular organisms, which seems to be an intrinsic property of the functional metabolism as a whole. Mathematical models firmly based on experiments and their corresponding computational approaches are needed to fully grasp the molecular mechanisms of metabolic dynamical processes. They are necessary to enable the quantitative and qualitative analysis of the cellular catalytic reactions and also to help comprehend the conditions under which the structural dynamical phenomena and biological rhythms arise. Understanding the molecular mechanisms responsible for the metabolic dissipative structures is crucial for unraveling the dynamics of cellular life.
de la Fuente
Ildefonso Martínez
IM
Institute of Parasitology and Biomedicine "López-Neyra" (CSIC), Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n, 18100 Armilla (Granada), Spain; E-Mail: mtpmadei@ehu.es ; Tel.: +34-958-18-16-21;
D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*