Prion transmission: prion excretion and occurrence in the environment.
Prion diseases range from being highly infectious, for example scrapie and CWD, which show facile transmission between susceptible individuals, to showing negligible horizontal transmission, such as BSE and CJD, which are spread via food or iatrogenically, respectively. Scrapie and CWD display considerable in vivo dissemination, with PrP(Sc) and infectivity being found in a range of peripheral tissues. This in vivo dissemination appears to facilitate the recently reported excretion of prion through multiple routes such as from skin, feces, urine, milk, nasal secretions, saliva and placenta. Furthermore, excreted scrapie and CWD agent is detected within environmental samples such as water and on the surfaces of inanimate objects. The cycle of "uptake of prion from the environment--widespread in vivo prion dissemination--prion excretion--prion persistence in the environment" is likely to explain the facile transmission and maintenance of these diseases within wild and farmed populations over many years.
School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Sutton Bonington, UK. kevin.gough@nottingham.ac.uk
Kevin C
KC
Gough
Ben C
BC
Maddison
D000818:Animals; D004777:Environment; D005243:Feces / Q000737:chemistry; D006801:Humans; D018620:PrPSc Proteins / Q000378:metabolism; D017096:Prion Diseases / Q000473:pathology / Q000635:transmission*; D011328:Prions / Q000032:analysis* / Q000472:pathogenicity; D012867:Skin / Q000378:metabolism
D018620:PrPSc Proteins; D011328:Prions