Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use.
OBJECTIVE
To examine variation in positive and negative subjective effects to alcohol, tobacco and marijuana and covariation between these three drugs and each effect.


METHODS
Retrospective self-reports of subjective effects were collected to estimate the genetic and environmental influences and the extent of their specificity across three drugs.


METHODS
Data were drawn from 1299 adolescent and young adult same- and opposite sex twin- and sibling-pairs participating in the Colorado Center for Antisocial Drug Dependence (CADD).


METHODS
A large, collaborative, longitudinal study of substance use and antisocial behavior in community and clinical adolescents.


METHODS
Subjective effects were assessed using a 13-item questionnaire that included positive and negative responses to alcohol, tobacco and marijuana.


RESULTS
Heritable influences contributed moderately (additive genetic effects 16-56%) to positive and negative subjective effects to all three drugs and did not differ for males and females. Genetic and environmental contributions to positive and negative subjective effects are largely non-overlapping for tobacco and marijuana. Multivariate genetic modeling indicated that subjective effects to alcohol, tobacco and marijuana share a common, heritable etiology and that drug-specific genetic influences were an important contributor to individual differences in drug response.


CONCLUSIONS
Results from our genetic analyses suggest that subjective effects to these commonly used and misused drugs are heritable and that the genetic and environmental influences on effects to one drug also influence subjective effects to other drugs.
Haberstick
Brett C
BC
Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA. brett.haberstick@colorado.edu
Zeiger
Joanna S
JS
Corley
Robin P
RP
Hopfer
Christian J
CJ
Stallings
Michael C
MC
Rhee
Soo Hyun
SH
Hewitt
John K
JK
D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology; D002186:Cannabinoids / Q000494:pharmacology; D004200:Diseases in Twins; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000235:genetics* / Q000523:psychology; D015233:Models, Statistical; D009538:Nicotine / Q000494:pharmacology; D010641:Phenotype; D012189:Retrospective Studies; D057566:Self Report; D012907:Smoking / Q000235:genetics* / Q000523:psychology; D012931:Social Environment; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology; D055815:Young Adult
D002186:Cannabinoids; D000431:Ethanol; D009538:Nicotine