New drugs for HIV-1: challenges and novel candidates.
The XVIII International Conference of the International AIDS Society held in Vienna on the 18-23 July 2010 brought together scientists, clinicians, policymakers, people living with HIV/AIDS and journalists from across the globe. Keynote speakers relevant to the theme of this report included Sharon Lewin (Alfred Hospital, Melbourne, Australia) and Tae-Wook Chun (National Institute of Allergy and Infectious Diseases, MA, USA), among others. A total of 19,100 delegates from across 193 countries attended the conference, which comprised 248 sessions, accompanied by 6238 abstracts and posters. The remit was broad, covering scientific, social and political aspects of the HIV/AIDS epidemic. This article focuses on the issue of eliminating latent reservoirs of HIV-1 infection, highlighting selected potential novel therapeutic interventions in overcoming challenges in HIV-1 suppression.
Ward
Christopher James Kevin
CJ
Brighton and Sussex Medical School, Brighton, BN1 9RH, UK. cjkward@doctors.org.uk
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001310:Auranofin; D002460:Cell Line; D003226:Congresses as Topic; D004197:Disease Reservoirs; D015195:Drug Design; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D051379:Mice; D016032:Randomized Controlled Trials as Topic; D045522:Recombinases / Q000378:metabolism; D017735:Virus Latency / Q000187:drug effects*
D019380:Anti-HIV Agents; D045522:Recombinases; D001310:Auranofin