[RNA interference as a potential tool for diagnosis and therapy of some human diseases].
RNA interference is one of the most important discoveries in the field of molecular biology. To date, many studies have been reported which suggest that RNA interference takes part in various biological processes essential for the development of many diseases. On the other hand, owing to its high specificity and efficiency, RNA interference has become a powerful tool in gene therapy. However, introduction of small interfering RNAs (siRNAs) to a target tissue requires overcoming some critical biological barriers. This, in turn, contributes to searching for new effective vectors, which should selectively penetrate the tissue and be able to exclude the innate immune response. This study provides a brief overview of the application of RNA interference in the diagnosis and therapy of some human diseases.
Zakład Cytobiochemii, Katedra Cytobiochemii, Uniwersytet Łódzki, 90-237 Łódź.
Paweł
P
Jóźwiak
Anna
A
Lipińska
D004194:Disease / Q000235:genetics*; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000627:therapeutic use; D006801:Humans; D034622:RNA Interference