MRI assessment of changes in liver iron deposition post-venesection.
OBJECTIVE
The aim of this study was to determine if changes in hepatic iron content in patients with hemochromatosis pre- and post-venesection could be detected by changes in liver signal intensity with MRI.


METHODS
The study was performed with institutional ethics approval and with informed consent. Gradient echo images were performed on 20 patients with hemochromatosis pre- and post-venesection and 10 control subjects: gradient echo T1-weighted in- and out-phases (4.54 (in)/2.27 (out), 167 [TE/TR], Flip 70°) and gradient echo T2* (5/18 [TE/TR], Flip 10°). The liver to muscle signal ratio was compared pre- and post-venesection.


RESULTS
All MRI sequences showed significant correlation between the liver to muscle signal intensity ratio and the serum ferritin pre-venesection [r=-0.70, -0.65, -0.74, -0.72, in/out/T2*r/T2*, respectively]. There was a significant increase on all sequences in the liver to muscle signal intensity ratio post-venesection (p<0.001). The control group and patients post-venesection had almost identical liver to muscle signal intensity ratios.


CONCLUSIONS
The reduction in liver signal intensity caused by iron excess in hemochromatosis returns to normal post-venesection. Measurement of liver to muscle signal intensity ratios may be a useful tool in assessing treatment response in iron overload states.
Department of Radiology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. pbeddy@eircom.net
P
P
Beddy
J
J
McCann
M
M
Ahern
S
S
Norris
M
M
Keogan
D016022:Case-Control Studies; D005260:Female; D005293:Ferritins / Q000097:blood; D006432:Hemochromatosis / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D019190:Iron Overload / Q000175:diagnosis* / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy; D011446:Prospective Studies; D016896:Treatment Outcome
D005293:Ferritins