Drug-induced aseptic meningitis, sensorineural hearing loss and vestibulopaty.
We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
Sepcić
Juraj
J
School of Medicine, Rijeka University, Rijeka, Croatia.
Bucuk
Mira
M
Perković
Olivio
O
Sepić-Grahovac
Dubravka
D
Troselj-Vukić
Biserka
B
Poljak
Ivica
I
Crnić-Martinović
Marija
M
Turel
Iztok
I
Ristić
Smiljana
S
Sepcić
Kristina
K
D002939:Ciprofloxacin / Q000009:adverse effects; D004347:Drug Interactions; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D008582:Meningitis, Aseptic / Q000139:chemically induced*; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects; D014012:Tinnitus / Q000139:chemically induced; D020338:Vestibular Neuronitis / Q000139:chemically induced*
D002939:Ciprofloxacin; D011899:Ranitidine; D007052:Ibuprofen