A novel mucosal RORγtNKp46 cell subset is a source of interleukin-22.
Lymphoid tissue-inducer cells are hematopoietic cells essential for the organogenesis of several lymphoid structures during both fetal and adult life, whereas natural killer cells are key effector lymphocytes of the innate immune system. A series of recent reports has identified RORγt(+)NKp46(+) interleukin-22-producing cells in gut and tonsils that share features with both lymphoid tissue-inducer cells and natural killer cells and that may be involved in mucosal immunity and homeostasis.
Centre d Immunologie de Marseille-Luminy, Université de la Méditerranée, INSERM U631, CNRS UMR 6102, 163 Avenue du Luminy, Case 906, 13288 Marseille CEDEX 09, France.
Elena
E
Tomasello
Ana
A
Reynders
Eric
E
Vivier