CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman.
BACKGROUND
Pagetoid reticulosis is a rare variant of mycosis fungoides. This rare condition typically presents as a solitary plaque located on the extremities with an indolent clinical course (Woringer-Kolopp disease) or as a more generalized presentation with diffuse cutaneous involvement and a more aggressive clinical course (Ketron-Goodman disease).


OBJECTIVE
To review the cutaneous manifestations, pathology, and treatment of localized pagetoid reticulosis.


METHODS
The authors describe a 24-year-old woman with a slowly enlarging, localized plaque of seven months duration, representing the localized form of pagetoid reticulosis with CD8+ immunophenotype.


RESULTS
The histological, immunohistochemical, and clinical features of the patient's skin lesion were characteristic for a diagnosis of Woringer-Kolopp disease. Systemic work-up for lymphoma was negative.


CONCLUSIONS
Woringer-Kolopp disease is most commonly seen in middle-aged men as a solitary lesion of the extremities, and it should always be considered in the differential diagnosis when a patient presents with such a lesion. A histological analysis demonstrated atypical lymphocytes preferentially localized to the epidermis with a CD4+, CD8+, or CD4-/CD8- phenotype. The treatment of choice for a solitary lesion may be localized radiation therapy, but newer therapies, such as bexarotene, may warrant further investigation.
Stephanie J
SJ
Martin
Philip R
PR
Cohen
Jeong Hee
JH
Cho-Vega
Jaime A
JA
Tschen