Dietary acrylamide intake and risk of breast cancer in the UK women's cohort.
BACKGROUND
No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide.


METHODS
A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33,731 women aged 35-69 years from the UK Women's Cohort Study followed up for a median of 11 years.


RESULTS
In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio=1.08 per 10 μg day(-1), 95% CI: 0.98-1.18, P(trend)=0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio=1.2, 95% CI: 1.0-1.3, P(trend)=0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio=1.0, 95% CI: 0.9-1.1, P(trend)=0.99).


CONCLUSIONS
There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation.
Centre for Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9JT, UK.
V J
VJ
Burley
D C
DC
Greenwood
S J
SJ
Hepworth
L K
LK
Fraser
T M
TM
de Kok
S G
SG
van Breda
S A
SA
Kyrtopoulos
M
M
Botsivali
J
J
Kleinjans
P A
PA
McKinney
J E
JE
Cade
D020106:Acrylamide / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced*; D015331:Cohort Studies; D004032:Diet; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D006113:United Kingdom
D020106:Acrylamide