Pharmacokinetics of buprenorphine in a sodium carboxymethylcellulose gel after buccal transmucosal administration in dogs.
Alternatives to intravenous administration of opioids are needed in veterinary medicine. Previous research suggests that opioids can be administered through the buccal mucosa in dogs. This study reports the pharmacokinetics of buprenorphine HCl (0.05 mg/kg) administered transmucosally in six dogs compared with those of buprenorphine HCl (0.015 mg/kg) administered intravenously. The results suggest that the pharmacokinetics of buprenorphine HCl administered intravenously or transmucosally are similar and that transmucosal administration may be considered as a noninvasive alternative to intravenous administration.
Krotscheck
Ursula
U
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, NY, USA.
Boothe
Dawn Merton
DM
Little
Amy A
AA
Erb
Hollis N
HN
D058956:Administration, Mucosal; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D002047:Buprenorphine / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D004285:Dogs / Q000097:blood*; D005260:Female; D006207:Half-Life; D008297:Male
D000701:Analgesics, Opioid; D002047:Buprenorphine; D002266:Carboxymethylcellulose Sodium