Status of toxic metals in biological samples of diabetic mothers and their neonates.
The mechanism of transport of trace elements from the mother to the newborn is still not well known. The aim of present study was to compare the status of trace toxic elements, arsenic (As), cadmium (Cd), and lead (Pb) in biological samples (whole blood, urine and scalp hair) of insulin-dependent diabetic mothers (age ranged 30-40) and their newly born infants (n = 76). An age and socioeconomics matched 68 nondiabetic mothers and their infants, residing in the same locality, who were selected as referents. The elemental concentrations in all three biological samples were determined by an electrothermal atomic absorption spectrometer, prior to microwave-assisted acid digestion. The mean values of As, Cd, and Pb in all biological samples of diabetic mothers and their infants were significantly higher as compared to the referent mother-infant pair samples (p < 0.01). The high levels of As, Cd, and Pb in biological samples of diabetic women may play a role in the pathogenesis of diabetes mellitus and impacts on their neonates.
Kolachi
Nida Fatima
NF
Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan.
Kazi
Tasneem Gul
TG
Afridi
Hassan Imran
HI
Kazi
Naveed
N
Khan
Sumaira
S
Kandhro
Ghulam Abbas
GA
Shah
Abdul Qadir
AQ
Baig
Jameel Ahmed
JA
Wadhwa
Sham Kumar
SK
Shah
Faheem
F
Jamali
Mohammad Khan
MK
Arain
Mohammad Balal
MB
D000328:Adult; D001151:Arsenic / Q000097:blood / Q000652:urine; D002104:Cadmium / Q000097:blood / Q000652:urine; D005260:Female; D006197:Hair / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D008297:Male; D011247:Pregnancy; D012535:Scalp / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000097:blood* / Q000378:metabolism / Q000652:urine*; D015032:Zinc / Q000097:blood / Q000652:urine
D014131:Trace Elements; D002104:Cadmium; D015032:Zinc; D001151:Arsenic