Tumor therapy with Amanita phalloides (death cap): stabilization of B-cell chronic lymphatic leukemia.
BACKGROUND
Molecular events that cause tumor formation upregulate a number of HOX genes, called switch genes, coding for RNA polymerase II transcription factors. Thus, in tumor cells, RNA polymerase II is more active than in other somatic cells. Amanita phalloides contains amanitin, inhibiting RNA polymerase II. Partial inhibition with amanitin influences tumor cell--but not normal cell--activity.


OBJECTIVE
To widen the treatment spectrum, homeopathic dilutions of Amanita phalloides, containing amanitin, were given to a patient with leukemia. Monitoring the leukemic cell count, different doses of amanitin were given.


RESULTS
The former duplication time of leukemic cells was 21 months. Within a period of 21 months, the cell count is stabilized to around 10(5)/μL. No leukemia-associated symptoms, liver damage, or continuous erythrocyte deprivation occur.


CONCLUSIONS
This new principle of tumor therapy shows high potential to provide a gentle medical treatment.
Riede
Isolde
I
Independent Cancer Research, Ueberlingen, Germany. riede@tumor-therapie.info
D000545:Amanita / Q000737:chemistry*; D000546:Amanitins / Q000494:pharmacology / Q000627:therapeutic use*; D002452:Cell Count; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006705:Homeopathy; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors*
D000546:Amanitins; D004791:Enzyme Inhibitors; D012319:RNA Polymerase II