Palmar fasciitis with polyarthritis syndrome in a patient with breast cancer.
Palmar fasciitis and polyarthritis syndrome (PFPAS) is a rare paraneoplastic syndrome often associated with ovarian and pancreatic cancers, and rarely lung and breast cancers. A 39-year-old patient with breast cancer underwent neoadjuvant chemotherapy, radical mastectomy, and radiation therapy. Subsequently, the patient developed PFPAS coinciding with progression of the breast cancer. The rheumatological symptoms were severe causing significant distress and handicap. The patient had a partial response to treatment with corticosteroids. A literature review of PFPAS and its relation to breast cancer is discussed.
Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham St., Slot 634, Little Rock, AR 72205, USA. kkrishna@uams.edu
Kavya
K
Krishna
Abdulraheem
A
Yacoub
Laura F
LF
Hutchins
Patrick M
PM
Kortebein
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D044584:Carcinoma, Ductal / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005208:Fasciitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D009288:Naproxen / Q000627:therapeutic use; D020360:Neoadjuvant Therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use; D011878:Radiotherapy
D000893:Anti-Inflammatory Agents; D009288:Naproxen; D011241:Prednisone