Characterization of Aedes albopictus akirin for the control of mosquito and sand fly infestations.
The control of arthropod vectors of pathogens that affect human and animal health is important for the eradication of vector-borne diseases. Recent evidences showed a reduction in the survival and/or fertility of mosquitoes, sand flies and poultry red mites fed in vitro with antibodies against the recombinant Aedes albopictus akirin. These experiments were the first step toward the development of a multi-target arthropod vaccine. In this study, we showed that the oviposition of A. albopictus and Phlebotomus perniciosus fed on mice vaccinated with recombinant A. albopictus akirin was reduced by 17% and 31%, respectively when compared to controls. However, Aedes aegypti mosquitoes were not affected after feeding on vaccinated mice. These results showed that recombinant A. albopictus akirin could be used to vaccinate hosts for the control of mosquito and sand fly infestations and suggested new experiments to develop improved vaccine formulations.
Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain.
Juan A
JA
Moreno-Cid
Maribel
M
Jiménez
Sylvie
S
Cornelie
Ricardo
R
Molina
Pedro
P
Alarcón
Marie-Noelle
MN
Lacroix
Rocío
R
Pinal
Sarah
S
Delacour
Javier
J
Lucientes
Mario
M
Canales
José M
JM
Pérez de la Lastra
Margarita
M
Villar
José
J
de la Fuente
D000330:Aedes / Q000254:growth & development*; D000818:Animals; D004199:Disease Vectors; D005260:Female; D007300:Insect Control / Q000379:methods*; D019476:Insect Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010058:Oviposition / Q000276:immunology; D011576:Psychodidae / Q000254:growth & development*
D019476:Insect Proteins