Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein.
Although angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT(1) or AT(2)) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological receptors involved in the angiotensin II-induced constriction of rat venae cavae and femoral veins, as well as the opposing effects exerted by locally produced prostanoids and NO upon induction of these vasomotor responses. The obtained results suggest that both AT(1) and AT(2) angiotensin II receptors are expressed in both veins. Angiotensin II concentration-response curves were shifted toward the right by losartan but not by PD 123319 in both the vena cava and femoral vein. Moreover, it was observed that both 10(-5)M indomethacin and 10(-4)M L-NAME improve the angiotensin II responses in the vena cava and femoral vein. In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT(1) but not AT(2) to induce venoconstriction, which is blunted by vasodilator prostanoids and NO.
Faculty of Pharmacy and Biochemistry, University of Marilia, SP, Brazil.
Osmar Gomes
OG
da Silva
Patrícia de Souza
Pde S
Rossignoli
Maria Alícia
MA
Carrillo-Sepúlveda
Maria Luiza Morais
ML
Barreto-Chaves
Agnaldo Bruno
AB
Chies
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D005268:Femoral Vein / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D019808:Losartan / Q000494:pharmacology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism*; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology; D014682:Vena Cava, Inferior / Q000187:drug effects*
D007093:Imidazoles; D011725:Pyridines; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; C073402:PD 123319; D019808:Losartan; D019331:NG-Nitroarginine Methyl Ester