Inflammatory breast cancer: the disease, the biology, the treatment.
Inflammatory breast cancer (IBC) is a rare and aggressive form of invasive breast cancer accounting for 2.5% of all breast cancer cases. It is characterized by rapid progression, local and distant metastases, younger age of onset, and lower overall survival compared with other breast cancers. Historically, IBC is a lethal disease with less than a 5% survival rate beyond 5 years when treated with surgery or radiation therapy. Because of its rarity, IBC is often misdiagnosed as mastitis or generalized dermatitis. This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy.
Robertson
Fredika M
FM
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Bondy
Melissa
M
Yang
Wei
W
Yamauchi
Hideko
H
Wiggins
Shannon
S
Kamrudin
Samira
S
Krishnamurthy
Savitri
S
Le-Petross
Huong
H
Bidaut
Luc
L
Player
Audrey N
AN
Barsky
Sanford H
SH
Woodward
Wendy A
WA
Buchholz
Thomas
T
Lucci
Anthony
A
Ueno
Naoto T
NT
Ueno
Naoto
N
Cristofanilli
Massimo
M
D014408:Biomarkers, Tumor / Q000235:genetics; D015992:Body Mass Index; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy / Q000379:methods; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D058922:Inflammatory Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008327:Mammography; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications; D049268:Positron-Emission Tomography; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D035583:Rare Diseases; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016217:Ultrasonography, Mammary; D014481:United States / Q000453:epidemiology
D014408:Biomarkers, Tumor