Targets and non-targets in the aging brain: A go/nogo event-related potential study.
This study tested whether older adults show enhanced suppression of inappropriate processing of non-target information, as marked with the nogo-P3 event-related potential (ERP). Healthy younger and older adults were tested on a simple go/nogo task with visually presented numbers. Unlike in most of the previous studies, go and nogo stimuli were matched for frequency and conflict level in order to minimize the impact of task difficulty, probability monitoring, or conflict detection and resolution on the age-related ERP differences. Older adults showed slower go responses but a comparable accuracy to younger controls. The parietal go-P3 latency was also delayed with aging, while the central nogo-P3 was more pronounced in older adults than in younger controls. The amplitude of this component negatively correlated with go-RTs. In line with previous studies, this suggests that a partial response preparation to nogo events is strongly suppressed in older adults, especially faster ones.
International School for Advanced Studies, SISSA, Trieste, Italy. vallesi@sissa.it
Antonino
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Vallesi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult