Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon.
In this work, nanostructured particles of porous silicon are demonstrated to act as an effective carrier for the sustained delivery of antibacterial agents with an enhanced inhibitory activity. Methods are described for the incorporation of significant amounts of the established antibacterial compound triclosan (Irgasan) into mesoporous silicon of varying porosities. Such materials were characterized by a combination of scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), and antimicrobial assays. Assessment of antibacterial activity was carried out versus the bacterium Staphylococcus aureus as a function of time with concomitant assessment of triclosan release; significant, sustained inhibition of bacterial growth is demonstrated in the triclosan-containing porous Si for time intervals greater than 100 days. Significantly, enhanced dissolution (relative to room temperature equilibrium solubility) of the triclosan was observed for the initial 15 days of drug release, inferring some amorphization or nanostructuring by the porous Si matrix.
Department of Chemistry, Texas Christian University, Ft Worth, Texas 76129, United States.
Mengjia
M
Wang
Jeffery L
JL
Coffer
Katrina
K
Dorraj
Phil S
PS
Hartman
Armando
A
Loni
Leigh T
LT
Canham
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D016503:Drug Delivery Systems; D008826:Microbial Sensitivity Tests; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012825:Silicon / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013499:Surface Properties; D014260:Triclosan / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014260:Triclosan; D012825:Silicon