A review of clinical diagnostic applications of liquid chromatography-tandem mass spectrometry.
Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) technology is emerging as a complementary method to traditional methodology used for clinical applications. Enhanced specificity and high-throughput capabilities are providing significant benefits to clinical diagnostic laboratories conducting routine analyses. This technology is expected to expand rapidly as scientists focus on more complicated challenges that can be solved efficiently by adding LC/MS/MS to their arsenal of techniques.
Shushan
Bori
B
Clinical Mass Spec Consultants, Toronto, ON, Canada, M4W 2W6. bori@rogers.com
D015415:Biomarkers / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D019411:Clinical Laboratory Techniques / Q000295:instrumentation*; D006801:Humans; D055432:Metabolomics; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D053719:Tandem Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
D015415:Biomarkers; D010455:Peptides; D011506:Proteins