Neural correlates of hemispatial neglect: a voxel-based SPECT study.
BACKGROUND
Despite many studies that investigated the neural correlates of hemispatial neglect (HN) with structural imaging, studies using voxel-wise analyses of functional imaging are not available. Furthermore, previous studies neither considered the neglect severity nor investigated whether there are differences in these neural correlates according to each neglect subtest. This study aimed to investigate the neural correlates of HN by correlating the total and the individual neglect score with hypoperfusion value on single photon emission computed tomography (SPECT) using voxel-wise analyses.


METHODS
Forty-two patients with acute right hemisphere strokes underwent a neglect test battery consisting of 3 bisection tasks, 2 cancellation tasks and 2 copying tasks. The SPECT images were acquired in these patients and 10 age- and education-matched normal controls.


RESULTS
Patients with HN, compared to those without HN, had hypoperfusion in the right middle temporal-occipital junction, inferior frontal gyrus and retrosplenial area. The total neglect score correlated with the hypoperfusion in the right middle temporal-occipital junction, fusiform gyrus, parahippocampal gyrus, inferior temporal gyrus, anterior part of the superior and middle temporal gyri, cuneus, lingual gyrus, angular gyrus, and the cerebellum. Across the neglect subtests similar correlation patterns were observed with minor variations.


CONCLUSIONS
Unlike the results of previous studies showing that the critical neural correlates for HN are inferior parietal lobule or superior temporal gyrus, our study showed that the lesions that critically contribute to the neglect severity were located in the posterior parts of the middle temporal gyrus (temporal-occipital junction).
Lee
Byung Hwa
BH
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-gu, Seoul, Republic of Korea.
Kang
Eunjoo
E
Cho
Sang Soo
SS
Kim
Eun-Joo
EJ
Seo
Sang Won
SW
Kim
Gyeong-Moon
GM
Lee
Kwang Ho
KH
Na
Duk L
DL
D000368:Aged; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D056910:Republic of Korea; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D015899:Tomography, Emission-Computed, Single-Photon