The risk of cytogenetic abnormalities in the late first trimester of pregnancies conceived through assisted reproduction.
OBJECTIVE
To determine if pregnancies conceived through infertility treatment are at increased risk of cytogenetic abnormalities in the late first trimester compared with spontaneously conceived pregnancies, or if there is increased risk when comparing less invasive infertility treatment (in vivo group) to in vitro fertilization (in vitro group).


METHODS
Retrospective case-controlled study.


METHODS
University hospital.


METHODS
A total of 1,606 women who spontaneously conceived and 559 women who conceived through infertility treatment undergoing chorionic villus sampling (CVS).


METHODS
None.


METHODS
Cytogenetic abnormalities diagnosed by CVS.


RESULTS
No difference in cytogenetic abnormalities was found when comparing spontaneously conceived pregnancies to those conceived through infertility treatment (7.0% versus 5.4%). We also found no difference in the prevalence of cytogenetic abnormalities when comparing in vivo and in vitro fertilization subgroups (4.7% versus 5.8%). Finally, no difference was found when comparing the prevalence of different types of cytogenetic abnormalities between groups.


CONCLUSIONS
Infertility treatment does not increase the risk of carrying a cytogenetically abnormal fetus in the late first trimester, nor does it increase the preponderance for any specific type of abnormality.
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Deirdre A
DA
Conway
Satin S
SS
Patel
Jennifer
J
Liem
Kenneth J
KJ
Fan
Ray
R
Jalian
John
J
Williams
Margareta D
MD
Pisarska
D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D025063:Chromosome Disorders / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007246:Infertility / Q000453:epidemiology / Q000628:therapy; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000235:genetics; D015995:Prevalence; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012306:Risk