Gastroretentive dosage forms: a review with special emphasis on floating drug delivery systems.
In the present era, gastroretentive dosage forms (GRDF) receive great attention because they can improve the performance of controlled release systems. An optimum GRDF system can be defined as a system which retains in the stomach for a sufficient time interval against all the physiological barriers, releases active moiety in a controlled manner, and finally is easily metabolized in the body. Physiological barriers like gastric motility and gastric retention time (GRT) act as obstacles in developing an efficient GRDF. Gastroretention can be achieved by developing different systems like high density systems, floating drug delivery systems (FDDS), mucoadhesive systems, expandable systems, superporous systems, and magnetic systems. All these systems have their own merits and demerits. This review focused on the various aspects useful in development of GRDF including the current trends and advancements.
Pawar
Vivek K
VK
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, NH- 58, Uttar Pradesh, 250002, India. vivekpharmaperson@gmail.com
Kansal
Shaswat
S
Garg
Garima
G
Awasthi
Rajendra
R
Singodia
Deepak
D
Kulkarni
Giriraj T
GT
D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics*; D005746:Gastric Emptying / Q000502:physiology; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans
D003692:Delayed-Action Preparations