Access to β,γ-diamino acids. Application to the synthesis of 3-deoxyaminostatine.
The synthesis of orthogonally protected diastereo- and enantiopure β,γ-diamino acids starting from natural α-amino acids is described, as well as its application to the synthesis of fully protected 3-deoxyaminostatine.
Bouillère
Francelin
F
Univ. Paris-Sud, Laboratoire de Chimie des Procédés et Substances Naturelles, Institut de Chimie Moléculaire et des Matériaux d'Orsay, UMR 8182, Bâtiment 410, Orsay, F-91405, France.
Guillot
Régis
R
Kouklovsky
Cyrille
C
Alezra
Valérie
V
D000599:Amino Acids, Diamino / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis
C556470:3-deoxyaminostatine; D000599:Amino Acids, Diamino; D011759:Pyrrolidines; C032519:pyrrolidine