Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis.
BACKGROUND
Data on the association between sex hormone receptor polymorphisms and migraine are conflicting.


METHODS
We performed a systematic review and meta-analysis on this topic searching for studies published until August 2009. For each study, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.


CONCLUSIONS
Among the seven genes targeted, four variants were investigated in multiple studies. Effect estimates from an additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine. This pattern does not differ between migraine with and without aura. In contrast, the ESR-1 Pvu II C>T and PGR PROGINS insert polymorphism do not appear to be associated with migraine. Results were driven by studies among Caucasians and may differ in other ethnic groups.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA. mschuerks@rics.bwh.harvard.edu
Markus
M
Schürks
Pamela M
PM
Rist
Tobias
T
Kurth
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D001141:Aromatase / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics; D000078723:Nuclear Receptor Interacting Protein 1; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011944:Receptors, Androgen / Q000235:genetics; D011962:Receptors, FSH / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D011944:Receptors, Androgen; D011962:Receptors, FSH; D011980:Receptors, Progesterone; D001141:Aromatase