The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia.
The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.
Department of Experimental Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N., Denmark. ohk@sund.ku.dk
Otto
O
Kalliokoski
Klas S P
KS
Abelson
Janne
J
Koch
Anna
A
Boschian
Sarah F
SF
Thormose
Natasha
N
Fauerby
Rune S
RS
Rasmussen
Flemming F
FF
Johansen
Jann
J
Hau
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000758:Anesthesia; D000821:Animal Feed; D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002047:Buprenorphine / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012646:Self Administration; D013312:Stress, Physiological / Q000187:drug effects*; D013514:Surgical Procedures, Operative
D000701:Analgesics, Opioid; D002047:Buprenorphine; D003345:Corticosterone