Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor.
Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor outcome. Interestingly, a hypophyseal tumor was detected simultaneously by magnetic resonance imaging in this case. We think it is probable that the tumor in the hypophysis might be associated with the ALCL.
Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China.
Lei
L
Wang
Yin
Y
Tong
Zhimei
Z
Chen
Weilai
W
Xu
Jie
J
Jin
D000328:Adult; D001706:Biopsy; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007621:Karyotyping; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D011014:Pneumonia / Q000150:complications; D016896:Treatment Outcome