[TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease].
OBJECTIVE
To study the association between single nucleotide polymorphisms of thioredoxin reductase-2 (TrxR2) gene and the susceptibility to Kashin-Beck disease (KBD).


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotype frequencies of rs5748469 in TrxR2 gene in 84 KBD patients and 109 healthy control subjects.


RESULTS
The genotype frequencies of A/A, A/C, and C/C in the KBD patients were 83.33%, 15.48% and 1.19%, as compared with the frequencies of 74.31%, 25.69%, and 0.00% in the healthy control, respectively, showing no significant difference in the single nucleotide polymorphisms of TrxR2 gene between the two groups (P=0.13).


CONCLUSIONS
No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to KBD.
Lu
Wei
W
School of Life Science and Technology, Xi'an Jiaotong University, College of Medicine, Xi'an 710049, China. luwei@stu.xjtu.edu.cn
Mo
Xiao-yan
XY
Xiong
Yong-min
YM
D000328:Adult; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D057767:Kashin-Beck Disease / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054482:Thioredoxin Reductase 2 / Q000235:genetics*
C516127:TXNRD2 protein, human; D054482:Thioredoxin Reductase 2