The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model - a cross-over study.
OBJECTIVE
To test the plaque inhibitory effect of an experimental 0.07% cetylpyridinium chloride (CPC) mouthrinse in a 3-day plaque accumulation model in a cross-over design.


METHODS
A total of 30 subjects (non-dental students), ≥18 years of age, were randomly assigned to use one of three different mouthrinses three times a day. After 3 days, the subjects returned for the clinical assessments and received a questionnaire to evaluate their attitude towards the product used by them. The cross-over procedure was repeated twice to have all subjects use all products.


RESULTS
A total of 29 subjects completed the protocol and this resulted in a statistically significant difference between the three groups (P < 0.001) with regard to plaque scores. Over three sessions, the mean plaque scores were 2.17 for the control product, 1.14 for the CPC group and 1.12 for the 0.1% Hexetidine product (positive control). Results of the questionnaire show that, compared with hexetidine, the taste of the CPC was appreciated better, and less oral sensations were observed following rinsing.


CONCLUSIONS
The CPC mouthrinse proved to be effective in inhibiting 'de novo' plaque formation to an extent similar to that of a 0.1% hexetidine product. Compared with hexetidine, the taste of the CPC was appreciated better and less oral sensations were observed following rinsing.
Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam, The Netherlands. p.versteeg@acta.nl
P A
PA
Versteeg
N A M
NA
Rosema
N L
NL
Hoenderdos
D E
DE
Slot
G A
GA
Van der Weijden
D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006590:Hexetidine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D013649:Taste; D055815:Young Adult
D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D006590:Hexetidine; D002594:Cetylpyridinium