Venous thromboembolism and port-related thrombosis in metastatic colorectal cancer patients: a monocenter experience.
Venous thromboembolism (VTE) may occur during the natural history of neoplastic disease and is a common cause of mortality and morbidity in cancer patients. Major risk factors for VTE in cancer patients include surgery, immobilization, hospitalization, and the administration of granulopoietic and/or erythropoietic (stimulatory) agents. Chemotherapy is a supplementary independent risk factor for VTE and the use of central venous catheters (CVC) in clinical practice has increased the risk of thromboembolic events. We conducted a retrospective study to evaluate CVC-related thrombosis and the VTE rate in 145 consecutive metastatic colorectal cancer patients. We observed only 2 cases of symptomatic CVC- related thrombotic events (1.38%) and 10 cases of thromboembolic events (6.9%) in our series. Only surgery for metastases was found to be significantly related to the development of VTE, with an incidence of 16.1% vs. 4.4 in patients who did not undergo surgery (p = 0.037). In addition, a history of VTE seems to be a supplementary risk factor for CVC-related thrombosis (p = 0.055).
'L & A Seragnoli' Department of Hematology and Oncological Sciences, University of Bologna, Bologna, Italy.
Elisabetta
E
Nobili
Roberto
R
Di Cicilia
Monica
M
Di Battista
Antonio Maria
AM
Morselli-Labate
Marco
M
Paragona
Jody
J
Corbelli
Marina
M
Macchini
Paolo
P
Prandoni
Guido
G
Biasco
Giovanni
G
Brandi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000556:secondary*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010045:Outpatients / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D056824:Upper Extremity Deep Vein Thrombosis / Q000453:epidemiology*; D054556:Venous Thromboembolism / Q000453:epidemiology*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil