Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C(18) column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01-10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.
Ogawa
Tadashi
T
Department of Legal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan. ogawatd@aichi-med-u.ac.jp
Hattori
Hideki
H
Kaneko
Rina
R
Ito
Kenjiro
K
Iwai
Masayo
M
Mizutani
Yoko
Y
Arinobu
Tetsuya
T
Ishii
Akira
A
Suzuki
Osamu
O
Seno
Hiroshi
H
D014150:Antipsychotic Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D013058:Mass Spectrometry; D010879:Piperazines / Q000097:blood*; D010880:Piperidines / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052617:Solid Phase Microextraction; D053719:Tandem Mass Spectrometry
D014150:Antipsychotic Agents; D010879:Piperazines; D010880:Piperidines; C079310:blonanserin