Roles of the small GTPases RhoA and Rac1 in cell behavior.
The Rho-family GTPases are proving to have a variety of biological functions apart from their well known effects on the cytoskeleton. Recent work indicates their involvement in signaling between the adhesion receptors integrin and syndecan, effects on the recruitment of beta-catenin to the nucleus, and potential roles in the nucleus as well as the cytoplasm.
Department of Cellular and Molecular Physiology, University of North Carolina at Chapel Hill, 5320 MBRB, Chapel Hill, NC, USA. Carol_Otey@med.unc.edu
Carol
C
Otey
Silvia
S
Goicoechea
Rafael
R
Garcia-Mata