[Clinical significance of apolipoprotein B-48 (apoB-48) in chronic kidney disease patients].
OBJECTIVE
Apolipoprotein B-48 (apoB-48) is a constituent of chylomicrons and their remnants, and high levels of serum apoB-48 are thought to be one of the risk factors for atherosclerosis. In the current study we examined whether serum apoB-48 level is associated with renal dysfunction.


RESULTS
Patients were separated by eGFR into each stage of chronic kidney disease (CKD). Serum apoB-48 levels were measured by chemiluminescence enzyme immunoassay (CLEIA), and serum lipid levels were compared between each stage of CKD. Serum triglyceride (TG) levels were high at stage 4 and stage 5. Serum total cholesterol, HDL-cholesterol (HDL-C), and LDL-cholesterol (LDL-C) levels were not significantly different. Serum apoB-48 level was significantly higher at stage 4 (Median: 8.3 microg/ml) and stage 5 (9.7 microg/ml) than at stage 1(4.2 microg/ml). Serum apoB-48 levels (10.7 microg/ml) in patients undergoing hemodialysis were not significantly higher than CKD patient of nondialysis (6.9 microg/ml).


CONCLUSIONS
Serum apoB-48 level was strongly associated with renal dysfunction. Therefore, increased serum apoB-48 concentrations may contribute to the increased risk of atherosclerosis and coronary artery disease in the CKD patients.
Division of Laboratory for Clinical Investigation, Department of Medical Technology, Osaka University Hospital, Suita 565-0871, Japan. ookubo@hp-lab.med.osaka-u.ac.jp
Manabu
M
Okubo
Hiroyuki
H
Hanada
Masahiko
M
Matsui
Yoh
Y
Hidaka
Daisaku
D
Masuda
Shizuya
S
Yamashita
D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D008875:Middle Aged
D053283:Apolipoprotein B-48