Antigen-driven T-cell repertoire selection during adaptive immune responses.
Protective immunity against a variety of infections depends on the amplification and differentiation of rare naïve antigen-specific CD4 and CD8 T cells. Recent evidence indicates that the clonotypic composition of the responding T-cell compartment has a critical role in the immune defense against pathogens. The present review compares and contrasts how naive CD4 and CD8 T cells recognize their cognate antigen, and discusses the factors that regulate the genesis and maintenance of the CD4 and CD8 T-cell receptor repertoire diversity.
Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53201-2178, USA.
Christina K
CK
Baumgartner
Laurent P
LP
Malherbe
D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D017637:Clonal Deletion / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000941:Antigens; D011948:Receptors, Antigen, T-Cell