Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome.
BACKGROUND
The cytokine interleukin-6 (IL-6) is important in both immune responses and cardiovascular diseases. The IL-6 promoter polymorphism -174 G/C is associated with increased plasma concentrations of IL-6. The relationship between IL-6 polymorphisms and graft survival, cardiovascular events, and new-onset diabetes mellitus after kidney transplantation is controversial.


OBJECTIVE
To analyze whether IL-6 (-174 G/C) polymorphism influences kidney graft survival or development of chronic allograft nephropathy, cardiovascular events, or new- onset diabetes.


METHODS
The IL-6 promoter polymorphism (-174 G/C) was analyzed using the polymerase chain reaction with sequence-specific primers in 335 kidney transplant recipients. Data for graft survival, chronic graft nephropathy, cardiovascular events, and new-onset diabetes were obtained retrospectively from clinical records. Categorical variables were compared between individuals with CC, GG, and GC genotypes using χ2 tests. Survival analysis was performed using the Kaplan-Meier method, comparing groups using the log-rank test.


RESULTS
No significant differences were observed in 5-year graft survival between individuals with CC and GC/GG genotypes (85.3% vs 77.1%; P=.22). Nor were significant differences noted in the rates of chronic allograft nephropathy (37.5% vs 33.8%; P=.48), cardiovascular events (10.0% vs 23.0%; P=.10), or new-onset diabetes (7.5% vs 11.8%; P=.28).


CONCLUSIONS
There is no association between IL-6 (-174 G/C) polymorphism and graft survival or development of chronic allograft nephropathy, cardiovascular events, or new- onset diabetes.
Sánchez-Velasco
P
P
Service of Immunology, Hospital Universitario Marqués de Valdecilla, Servicio Cántabro de Salud, Santander, Spain.
Rodrigo
E
E
Fernández-Fresnedo
G
G
Ocejo-Vinyals
J G
JG
Ruiz
J C
JC
Arnau
A
A
Leyva-Cobián
F
F
Arias
M
M
D006085:Graft Survival; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D015850:Interleukin-6