Is there a personalized medicine for mood disorders?
Major Depressive Disorder (MDD) and antidepressant therapy response are largely based on behavioral criteria, which are known to correlate at best modestly with biological measures. Therefore, it is not surprising that the search for peripheral biological markers (biomarkers) being assessed in distant biological systems such as body fluids has not yet resulted in clinically convincing measures for MDD diagnostics or treatment evaluation. Imaging genetics studies, however, have been successful in the search for intermediate imaging phenotypes of MDD and treatment response that are directly related to the neurobiological underpinnings of MDD, but are not suitable for a broad clinical use today. Hence, we argue that intermediate phenotypes derived from imaging genetics studies should be utilized as substitutes of behaviorally assessed psychiatric diagnoses or therapy response in the search for easily accessible peripheral biomarkers. This article will further cover the current state of peripheral and neural biomarker research.
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Lucie
L
Bartova
Andreas
A
Berger
Lukas
L
Pezawas
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D019964:Mood Disorders / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D057285:Precision Medicine; D014131:Trace Elements / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D015415:Biomarkers; D014131:Trace Elements; D014815:Vitamins; D003577:Cytochrome P-450 Enzyme System