Aneurysm and Helicobacter pylori relationship: the seropositivity of CagA, VacA and other antigens of Helicobacter pylori in abdominal and ascending aortic aneurysms.
Helicobacter pylori is thought to be related to atherosclerosis and aneurysm development. We aimed to detect virulance factors of H. pylori and examine the potential etiopathogenetic relationship between aortic aneurysm and H. pylori, 58 abdominal aortic aneurysm (AAA) and 38 ascending aortic aneurysm (AsAA) cases and 57 Healty control group (HCG) were included. We investigated H. pylori IgG by ELISA and virulance factors by Western-Blot (WB) method. No difference was found between AAA (67.24%), AsAA (73.68%) and HCG (57.89%) for H. pylori IgG (p > 0.05). A significant difference was found between AsAA (78.95%) and HCG (57.89%) for H.pylori IgG (p < 0.05) by ELISA and a significant difference was found only between AsAA (100%) and HCG (37.5%) for H. pylori IgG in the 45-55 age group by WB. A statistically significant difference was found between AAA and AsAA for VacA and CagA + VacA and CagA + VacA + UreA antigens and also a significant difference was found between AsAA and HCG for CagA + UreA antigens (p < 0.05). Finally, we suggest that H. pylori VacA has a more important role than CagA in the development of two aneurysms especially in ruptured AAA. New extended studies detecting H. pylori DNA are needed to detect the aetiopathogenesis between aneurysm types and H. pylori.
Ziver
Tevhide
T
Microbiology and Clinical Microbiology Department, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Yuksel
Pelin
P
Ipek
Gokhan
G
Yekeler
Ibrahim
I
Bayramoglu
Zehra
Z
Tireli
Emin
E
Saribas
Suat
S
Aslan
Mustafa
M
Yalvac
Seyma Denli
SD
Ozdomanic
Ibrahim
I
Torlak
Zuhal
Z
Dirican
Ahmet
A
Torun
Muzeyyen Mamal
MM
Kocazeybek
Bekir
B
D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000942:Antigens, Bacterial / Q000097:blood / Q000276:immunology*; D001014:Aortic Aneurysm / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000276:immunology / Q000382:microbiology; D001426:Bacterial Proteins / Q000097:blood / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori