[Results of lung transplantation].
BACKGROUND
Lung transplantation has experienced an increasing expansion with a significant improvement in results with the passage of time. Evaluation of these results consists of several domains: survival, function, quality of life and cost-effectiveness.


BACKGROUND
The success of lung transplantation is confirmed by a median survival that currently exceeds 5 years. Cystic fibrosis is the disease associated with the best results with, in France, a survival of 76% at 1 year, 56% at 5 years and 47% at 10 years and a median survival of 8 years. According to French data the 5-year survival is 46% for PAHT, 42% for COPD and 36% for pulmonary fibrosis. Studies have shown a survival benefit for cystic fibrosis and interstitial lung disease but definitive conclusions cannot be drawn for patients with COPD. Lung transplantation brings similar benefits in terms of quality of life and cost-effectiveness.


RESULTS
New statistical methods would allow a better estimate in terms of years of survival and quality of life to be made for each candidate on an individual basis.


CONCLUSIONS
Lung transplantation improves survival and quality of life compared to medical treatment, at an acceptable cost. These outcomes should be assessed at both an individual and social level to justify the resources involved.
Groupe de transplantation pulmonaire de Grenoble, pôle de médecine aiguë et communautaire, clinique de pneumologie, fédération Grenoble transplantation, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France. SQuetant@chu-grenoble.fr
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D000328:Adult; D000367:Age Factors; D000368:Aged; D003362:Cost-Benefit Analysis; D003550:Cystic Fibrosis / Q000401:mortality / Q000601:surgery; D017079:Exercise Tolerance; D005602:France / Q000453:epidemiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000401:mortality / Q000601:surgery; D017563:Lung Diseases, Interstitial / Q000401:mortality / Q000601:surgery; D016040:Lung Transplantation / Q000191:economics / Q000379:methods / Q000523:psychology / Q000706:statistics & numerical data; D008875:Middle Aged; D017060:Patient Satisfaction; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality / Q000601:surgery; D011656:Pulmonary Emphysema / Q000401:mortality / Q000601:surgery; D011658:Pulmonary Fibrosis / Q000401:mortality / Q000601:surgery; D011788:Quality of Life; D012086:Reoperation; D012129:Respiratory Function Tests; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome