The safety of drugs used in acid-related disorders and functional gastrointestinal disorders.
Medicines are frequently used in the management of acid-related disorders and functional gastrointestinal disorders. With the exception of complicated peptic ulcer disease, these disorders are not associated with appreciable mortality. Drug treatments have consequently been held to the highest standards of safety. Some medicines have been withdrawn or restricted based on assessments and perceptions of risk. However, the risk of serious toxicity is low for most of the agents discussed in this article. Assessments are made of the safety and adverse-event profiles of certain drug classes and, where appropriate, individual medicines. For conditions with a low risk of mortality or serious morbidity, clinicians need to balance the risks of potential adverse events with the anticipated benefits of a successful outcome of specific drug treatment.
Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 1400, Chicago, IL 60611, USA.
Neehar
N
Parikh
Colin W
CW
Howden
D000707:Anaphylaxis / Q000209:etiology; D001847:Bone Diseases / Q000139:chemically induced; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000209:etiology; D004347:Drug Interactions; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D011014:Pneumonia / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000209:etiology
D005765:Gastrointestinal Agents; D054328:Proton Pump Inhibitors