Pulmonary remodeling in asthma.
The inflammatory and immunologic processes responsible for asthma can produce permanently fixed obstructive lung disease unresponsive to medical therapy. This can be manifested clinically by the failure of a childhood asthmatic to reach full expected lung capacity at adulthood and by an accelerated decline in pulmonary capacity in adults. Recent studies have furthered our insight into the pathologic processes underlying these changes and the potential effects of therapy to prevent them.
Lieberman
Phil
P
University of Tennessee, College of Medicine, Departments of Medicine and Pediatrics, Division of Allergy and Immunology Memphis, TN 38120 USA.