Notch signaling pathway as a therapeutic target in breast cancer.
The highly conserved Notch signaling pathway is involved in regulating a number of key cellular processes. This pathway has been implicated in both the development and progression of breast cancer and has emerged as a possible therapeutic target. Several clinical trials are currently underway to determine if targeting the Notch pathway with drugs such as the γ-secretase inhibitors may be an effective therapeutic strategy that improves outcomes in this disease.
University of Toronto, Princess Margaret Hospital, 610 University Avenue, Suite 5-222, Toronto, Ontario, M5G 2M9.
Hamed
H
Al-Hussaini
Deepa
D
Subramanyam
Michael
M
Reedijk
Srikala S
SS
Sridhar
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy*; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D016896:Treatment Outcome
D051880:Receptors, Notch