Inflammatory pseudotumor: report of a case in the mandible.
BACKGROUND
Intraoral inflammatory pseudotumor (IPT) is a rare, benign non-neoplastic lesion that presents as a rapidly growing mass with aggressive behavior, which can be mistaken for a malignant process.


METHODS
This article presents a rare case of IPT of the mandible in a 70-year-old male patient. Examination of the oral cavity revealed a hemorrhagic soft mass of the mandibular region. The patient was treated with surgery. Histologic examination of the resected specimen showed proliferation of fascicular spindle cells and a dense, chronic inflammatory cell infiltrate consisting of neutrophils, eosinophils, and lymphocytes. Immunohistochemically, the spindle cells expressed vimentin, α smooth muscle actin, and CD68, indicating a diagnosis of IPT.


CONCLUSIONS
IPT is an unusual benign pathology in the oral and maxillofacial area. Because of its aggressive clinical and radiological features, it can be mistaken for a malignancy. We suggest that oral and maxillofacial surgeons should be aware of the specific features of IPT to avoid unnecessary aggressive treatments such as a radical resection.
Date
Akinori
A
Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Yamagata
Kenji
K
Onizawa
Kojiro
K
Yanagawa
Toru
T
Karube
Rei
R
Ishibashi
Naomi
N
Bukawa
Hiroki
H
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010157:Palatal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010160:Palate, Soft / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed