Enantioselective synthesis of anti-β-hydroxy-α-amido esters via transfer hydrogenation.
The asymmetric transfer hydrogenation of α-amido-β-keto esters to provide the corresponding anti-β-hydroxy-α-amido esters in good to excellent yields, diastereoselectivity, and enantioselectivity is reported. The procedure is operationally simple, and delicate handling of the catalyst is not necessary.
Organic Chemistry, KTH Chemical Science and Engineering, Royal Institute of Technology, 100 44 Stockholm, Sweden.
Brinton
B
Seashore-Ludlow
Piret
P
Villo
Christine
C
Häcker
Peter
P
Somfai
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism
D000577:Amides; D004952:Esters