211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice.
Breastfeeding jaundice is a common problem in neonates who were exclusively breastfed, but its pathogenesis is still unclear. The uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphism was shown to contribute to the development of neonatal hyperbilirubinemia. We hypothesize that the variation of UGT1A1 gene may contribute to neonatal breastfeeding jaundice. We prospectively enrolled 688 near-term and term infants who were exclusively breastfed (BF group) or were supplemented by infant formula partially (SF group) before onset of hyperbilirubinemia. Genotyping of the promoter and exon1 of UGT1A1 was performed in all neonates. Neonates in BF group had a significantly higher maximal body weight loss ratio, peak bilirubin level, and a greater incidence of hyperbilirubinemia than those in SF group. Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG). This phenomenon was only seen in BF group but not in SF group when subset analysis was performed. This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice.
Departments of Pediatrics and Medical Genetics, Graduate Institute of Clinical Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Hung-Chieh
HC
Chou
Mei-Huei
MH
Chen
Hwai-I
HI
Yang
Yi-Ning
YN
Su
Wu-Shiun
WS
Hsieh
Chien-Yi
CY
Chen
Huey-Ling
HL
Chen
Mei-Hwei
MH
Chang
Po-Nien
PN
Tsao
D001663:Bilirubin / Q000097:blood; D001903:Bottle Feeding; D001942:Breast Feeding / Q000009:adverse effects*; D016009:Chi-Square Distribution; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D041943:Infant Formula; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D000099148:UGT1A1 Enzyme
D001663:Bilirubin; D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme