Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior.
The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.
Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Genevieve
G
Konopka
Daniel H
DH
Geschwind
D000818:Animals; D001519:Behavior / Q000502:physiology*; D005075:Biological Evolution; D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D019143:Evolution, Molecular; D015870:Gene Expression / Q000235:genetics; D023281:Genomics; D006801:Humans; D010641:Phenotype