[Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital].
We reviewed the results of 6 patients with biphenotypic acute leukemia (BAL) which the diagnostic standard of the European Group for the Immunological Characterization of Leukemia (EGIL) at Sapporo Medical University Hospital between 2006 and 2008. There were 5 males and 1 females with an average age of 35 years. Among them, 4 were B lymphoid and myeloid, 2 were T lymphoid and myeloid, and one was T/B lymphoid. Two of 4 patients did not attain complete remission, and two relapsed after first treatment with acute myeloblastic leukemia (AML) protocol. On the other hand, two showed complete remission after the acute lymphoblastic leukemia (ALL) protocol. One of 4 patients survived who had been treated with hematopoietic stem cell transplantation as a post-remission therapy. The ALL protocol was good for the induction therapy. However, overall treatment-related deaths were 4 patients and considerable caution was necessary.
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine.
Kazuyuki
K
Murase
Satoshi
S
Iyama
Tsutomu
T
Sato
Rishu
R
Takimoto
Masayoshi
M
Kobune
Junji
J
Kato
D000293:Adolescent; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D015456:Leukemia, Biphenotypic, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult