Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena.
Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.
Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Jingqiu
J
Dai
Analia
A
Sorribas
Wesley Y
WY
Yoshida
Philip G
PG
Williams
D057055:Aspartic Acid Proteases / Q000037:antagonists & inhibitors*; D031213:Cordia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006254:Hawaii; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D010666:Phenylpropionates; C555324:sebestenoid C; C555325:sebestenoid D; D057055:Aspartic Acid Proteases