Two-photon fluorescent probes for metal ions.
Two-photon microscopy (TPM) has become an indispensible tool in biology and medicine owing to the capability of imaging the intact tissue for a long period of time. To make it a versatile tool in biology, a variety of two-photon probes for specific applications are needed. In this context, many research groups are developing two-photon probes for various applications. In this Focus Review, we summarize recent results on model studies and selected examples of two-photon probes that can detect intracellular free metal ions in live cells and tissues to provide a guideline for the design of useful two-photon probes for various in vivo imaging applications.
Division of Energy Systems Research, Ajou University, Suwon, 443-749 Korea. kimhm@ajou.ac.kr
Hwan Myung
HM
Kim
Bong Rae
BR
Cho
D000818:Animals; D001923:Brain Chemistry; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007477:Ions; D008670:Metals / Q000032:analysis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017785:Photons; D051381:Rats
D005456:Fluorescent Dyes; D007477:Ions; D008670:Metals