Nanoscaffold based stem cell regeneration therapy: recent advancement and future potential.
BACKGROUND
Over the past years, extensive research has been directed towards tissue engineering using conventional scaffolds. In-depth studies in this field have led to the realization that in vivo cells interact with the extracellular matrix, composed of nanofibers at sub-micron scale, which not only provides the mechanical support to the cells but also plays a key role in regulation of cellular behavior. This has led to the development of nanofibrous scaffold (NFS) technology which in combination with stem cells is emerging as an important tool in the development of tissue engineering and regenerative medicine.


METHODS
This review summarizes the three methods of nanofibrous scaffold preparation and provides a state-of-the-art update on the recent advancement in the use of nanoscaffolds in stem cell regeneration therapy.


RESULTS
The review gives the reader an insight on nanoscaffold based therapy methods, such as how these scaffolds can potentially be designed and used in successful development of stem cell based therapies.


CONCLUSIONS
NFS technology when coupled with stem cells and exploited in the right way has a strong potential of being used in stem cell based regenerative medicine.
Prakash
Satya
S
McGill University, Biomedical Engineering, 3775 University Street, Montreal, Quebec, Canada. satya.prakash@mcgill.ca
Khan
Afshan
A
Paul
Arghya
A
D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D036103:Nanotechnology / Q000639:trends; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D033581:Stem Cell Transplantation / Q000639:trends; D013234:Stem Cells / Q000502:physiology*; D054457:Tissue Scaffolds / Q000639:trends