[Modulating effects of androgens on development adaptive-compensatory processes in organism of experimental animals-males].
The purpose of research is the definition of androgens role and myocardial androgen receptors and sex steroids in males under metabolic and hormonal "stress" induced by the experimental diabetes. Research was carried out on 60 rats-males, mass 180,0-200,0 g. The diabetes reproduced by single injection of alloxan (200mg/kg). Androgen receptors were revealed by the radiometric and radioautography methods. The content of glucose, immunoreactive insulin, testosteron, estradiol, corticosteron and somatotropin were defined in animals blood plasma. On the early terms of alloxan diabetes estradiol concentration increase against a background of testosteron decrease which causes the "feminization" of the sexual hormonal balance. On the other side the increase of androgen receptors expression by cardiomyocytes causes the intensification of myocardium tissue physiologic ability to androgens perception positively influencing on the metabolism. Consequently, androgens provoke stimulating effect on the myocard metabolism in males at early stages of the experimental diabetes.
Didebulidze
N A
NA
Sumbadze
Ts M
TsM
Melikadze
E B
EB
Gvidani
S A
SA
Kakabadze
M Sh
MSh
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000728:Androgens / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood / Q000494:pharmacology / Q000502:physiology; D013006:Growth Hormone / Q000097:blood / Q000494:pharmacology / Q000502:physiology; D008297:Male; D051381:Rats; D012737:Sex Factors; D013739:Testosterone / Q000097:blood / Q000494:pharmacology / Q000502:physiology
D000728:Androgens; D001786:Blood Glucose; D013739:Testosterone; D004958:Estradiol; D013006:Growth Hormone; D003345:Corticosterone