MicroRNA biogenesis takes another single hit from microsatellite instability.
In this issue of Cancer Cell, Melo et al. show that mutation of a single allele of the Exportin-5 gene (XPO5) suffices to depress microRNA (miRNA) levels and promote tumorigenesis. Thus, XPO5 joins the ranks of DICER and TRBP as a haploinsufficient tumor suppressor in the miRNA biogenesis pathway.
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. helge.grosshans@fmi.ch
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Büssing