Developing vaccines to combat hookworm infection and intestinal schistosomiasis.
Hookworm infection and schistosomiasis rank among the most important health problems in developing countries. Both cause anaemia and malnutrition, and schistosomiasis also results in substantial intestinal, liver and genitourinary pathology. In sub-Saharan Africa and Brazil, co-infections with the hookworm, Necator americanus, and the intestinal schistosome, Schistosoma mansoni, are common. The development of vaccines for these infections could substantially reduce the global disability associated with these helminthiases. New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development.
Hotez
Peter J
PJ
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
Bethony
Jeffrey M
JM
Diemert
David J
DJ
Pearson
Mark
M
Loukas
Alex
A
D000740:Anemia / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D000947:Antigens, Helminth; D006725:Hookworm Infections / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D017221:Necator americanus / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000517:prevention & control*; D014612:Vaccines / Q000302:isolation & purification*; D017778:Vaccines, Combined / Q000302:isolation & purification
D000947:Antigens, Helminth; D014612:Vaccines; D017778:Vaccines, Combined