Probability of bystander effect induced by alpha-particles emitted by radon progeny using the analytical model of tracheobronchial tree.
Radiation-induced biological bystander effects have become a phenomenon associated with the interaction of radiation with cells. There is a need to include the influence of biological effects in the dosimetry of the human lung. With this aim, the purpose of this work is to calculate the probability of bystander effect induced by alpha-particle radiation on sensitive cells of the human lung. Probability was calculated by applying the analytical model cylinder bifurcation, which was created to simulate the geometry of the human lung with the geometric distribution of cell nuclei in the airway wall of the tracheobronchial tree. This analytical model of the human tracheobronchial tree represents the extension of the ICRP 66 model, and follows it as much as possible. Reported probabilities are calculated for various targets and alpha-particle energies. Probability of bystander effect has been calculated for alpha particles with 6 and 7.69 MeV energies, which are emitted in the (222)Rn chain. The application of these results may enhance current dose risk estimation approaches in the sense of the inclusion of the influence of the biological effects.
Faculty of Science, University of Kragujevac, R. Domanović 12, 34000 Kragujevac, Serbia.
B
B
Jovanović
D
D
Nikezić
D000512:Alpha Particles / Q000009:adverse effects*; D001980:Bronchi / Q000528:radiation effects*; D024201:Bystander Effect / Q000528:radiation effects*; D002467:Cell Nucleus / Q000528:radiation effects; D006801:Humans; D008168:Lung / Q000528:radiation effects*; D008954:Models, Biological; D011886:Radon / Q000009:adverse effects*; D014132:Trachea / Q000528:radiation effects*
D011886:Radon