No evidence of FGFR3 mutations in prostate cancer.
BACKGROUND
FGFR3 mutations are associated with a good clinical disease course in bladder tumors. Currently, prognostic markers to stratify prostate cancer (PCa) patients for conservative management are lacking. Conflicting results have been found on the presence of FGFR3 mutations in PCa. Our objective was to determine the prevalence of FGFR3 mutations in a subset of prostate tumors. Next, determine the prevalence of FGFR3 mutations in PCa patients with coexistent tumors in other tissues.


METHODS
Primary and locally advanced prostate tumors (n =132) were collected at our medical center. From the 132 PCa patients, 28 (21%) were diagnosed with coexistent primary tumors (bladder, skin, pancreas, renal cell, gastric, colon, hepatic, and lung). Tumors were analyzed by FGFR3 mutation analysis on exon 7, 10, and 15, known to harbor the most frequent mutations.


RESULTS
The prevalence of FGFR3 mutations in patients with only PCa was 0%. Most PCa patients presented with coexistent bladder (n=12) and bladder and skin tumors (n =7). Other coexistent tumors in PCa patients included: bladder and pancreatic cancer (n=1); bladder and renal cell carcinoma (n=1); bladder and gastric carcinoma (n=1); skin cancer (n=1); colon cancer (n= 3); hepatic carcinoma (n=1); and lung cancer (n = 1). FGFR3 mutations were detected in 9/15 (60%) analyzed bladder tumors.


CONCLUSIONS
FGFR3 mutations were absent in the investigated prostate tumors, suggesting a minor role of these mutations in tumorigenesis. Hence, FGFR3 mutation analysis is not suitable to select patients for conservative management. Interestingly, if a prostate tumor coincided with other tumors these were mostly bladder and skin.
Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Tahlita C M
TC
Zuiverloon
Joost L
JL
Boormans
Jan
J
Trapman
Geert J L H
GJ
van Leenders
Ellen C
EC
Zwarthoff
D004252:DNA Mutational Analysis / Q000379:methods; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA
D004273:DNA, Neoplasm; D051498:Receptor, Fibroblast Growth Factor, Type 3