Fast, efficient, mild, and metal-free synthesis of pyrroles by domino reactions in water.
(E)-β-Bromonitrostyrenes react with enaminones in water to afford pyrroles in excellent yields. The domino reaction constitutes a new, mild, and environmentally benign process for the fast and efficient synthesis of diverse pyrroles.
Rueping
Magnus
M
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany. magnus.rueping@rwth-aachen.de
Parra
Alejandro
A
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013343:Styrenes / Q000737:chemistry*; D014867:Water
D007659:Ketones; D011758:Pyrroles; D013343:Styrenes; D014867:Water