[Clinic pathologic analysis and evaluation of fibrosis in 17 cases of idiopathic interstitial pneumonia].
OBJECTIVE
To explore the general principles and the significance of histopathology for idiopathic interstitial pneumonia (IIP) diagnosis; and to investigate the quantitative parameters in evaluation of fibrosis degree of IIP.


METHODS
17 cases of IIP were collected from Peking University 1st Hospital between 2004 and 2009, which had relatively integrated clinical, radiological and pathological materials. Combining clinical and radiological characteristics, histological manifestations and fibrosis degree were analyzed according to American Thoracic Society/European Respiratory Society (ATS/ERS) international consensus classification. Immunohistochemical staining for CD34 and SMA were performed and the correlation between their expressive extent and fibrosis degree were analyzed.


RESULTS
17 cases of IIP were diagnosed by clinical-radiological-pathological comprehensive analysis, which included 9 cases of usual interstitial pneumonia, 5 cases of cryptogenic organizing pneumonia and 3 cases of nonspecific interstitial pneumonia; SMA expression showed positive correlation with degree of fibrosis (r=0.928, P=0.01), and CD34 expression showed negative correlation with degree of fibrosis (r=-0.606, P=0.01).


CONCLUSIONS
Histopathology plays an important role in the diagnosis and classification of IIP. By combining histopathologic pattern, clinical and radiological features, a definite type of IIP can be confirmed. Proper and sufficient biopsy specimens are the premise of right diagnosis.CD34 and SMA immunohistochemical staining can be used in routine practice to evaluate the fibrosis degree of IIP.
Department of Pathology, Peking University First Hospital, Beijing 100034, China.
Yang
Y
Li
Yan
Y
Xiong
Ting
T
Li
D000199:Actins / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D005355:Fibrosis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged
C541116:ACTA2 protein, human; D000199:Actins; D018952:Antigens, CD34