Tomographic molecular imaging of x-ray-excitable nanoparticles.
X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd(2)O(2)S:Eu phosphors in various phantoms. Imaging in an optically diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging.
Stanford University School of Medicine, Department of Radiation Oncology,875 Blake Wilbur Drive, Stanford, California 94305-5847, USA.
Guillem
G
Pratx
Colin M
CM
Carpenter
Conroy
C
Sun
Ravi P
RP
Rao
Lei
L
Xing
D005063:Europium / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008163:Luminescent Measurements / Q000295:instrumentation; D053758:Nanoparticles / Q000737:chemistry*; D019047:Phantoms, Imaging; D015898:Tomography Scanners, X-Ray Computed; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*; D014965:X-Rays
C021197:gadolinium sulfoxylate; D005063:Europium; D005682:Gadolinium