Microwave modified non-crosslinked pectin films with modulated drug release.
The effects of microwave on drug release properties of pectin films carrying sulfanilamide (SN-P), sulfathiazole (ST-P) and sulfamerazine (SM-P) of high to low aqueous solubilities were investigated. These films were prepared by solvent evaporation technique and treated by microwave at 80 W for 5-40 min. Their profiles of drug dissolution, drug content, matrix interaction and matrix crystallinity were determined by drug dissolution testing, drug content assay, differential scanning calorimetry, X-ray diffractometry and scanning electron microscopy techniques. Microwave induced an increase in matrix amorphousness but lower drug release propensity with a greater retardation extent in SN-P films, following a rise in strength of matrix interaction. A gain in amorphous structure does not necessarily increase the drug release of film. Microwave can possibly retard drug release of pectin film carrying water-soluble drug through modulating its state of matrix interaction.
Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia.
Nor Khaizan
NK
Anuar
Tin Wui
TW
Wong
Mohd Nasir
MN
Taib
D002152:Calorimetry, Differential Scanning; D002240:Carbohydrate Sequence; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry; D005079:Excipients / Q000737:chemistry* / Q000528:radiation effects*; D007202:Indicators and Reagents; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D008969:Molecular Sequence Data; D010368:Pectins / Q000737:chemistry* / Q000528:radiation effects*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D014961:X-Ray Diffraction
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D007202:Indicators and Reagents; D010368:Pectins