Effect of the antiviral drug oseltamivir (Tamiflu) on the bacterial community structure of a surface water ecosystem analyzed using fluorescence in situ hybridization.
The antiviral drug Tamiflu has received particular attention because of its recommended use against the influenza A H5N1 and H1N1 viruses. Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from sewage treatment plants. In the present paper the bacterial community of surface water samples, treated with OC (1.5 mg L⁻¹), was characterized by Fluorescence In Situ Hybridization (FISH) in microcosm experiments. The α-, β- and γ-Proteobacteria increased in OC-treated versus non-treated water samples during the incubation period, suggesting these bacterial groups had an active role in OC degradation.
Caracciolo
Anna Barra
AB
Water Research Institute-National Research Council, Monterotondo, Rome, Italy. barracaracciolo@irsa.cnr.it
Grenni
Paola
P
Saccà
Maria Ludovica
ML
D020561:Alphaproteobacteria / Q000187:drug effects / Q000254:growth & development; D000998:Antiviral Agents / Q000737:chemistry / Q000633:toxicity*; D001419:Bacteria / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D020562:Betaproteobacteria / Q000187:drug effects / Q000254:growth & development; D058448:Biota; D005618:Fresh Water / Q000737:chemistry / Q000382:microbiology*; D020563:Gammaproteobacteria / Q000187:drug effects / Q000254:growth & development; D057927:Hydrophobic and Hydrophilic Interactions; D017404:In Situ Hybridization, Fluorescence; D053139:Oseltamivir / Q000737:chemistry / Q000633:toxicity*; D014871:Water Microbiology; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity
D000998:Antiviral Agents; D014874:Water Pollutants, Chemical; D053139:Oseltamivir