Reinforcement of pancreticojejunostomy using polyglycolic acid mesh and fibrin glue sealant.
OBJECTIVE
To examine whether pressure-tight reinforcement of pancreaticojejunostomy (PJ) using polyglycolic acid (PGA) mesh and fibrin glue sealant can reduce the incidence of postoperative pancreatic fistula (POPF).


METHODS
The study population included 128 consecutive patients who underwent pancreaticoduodenectomy between September 2006 and January 2010. Postoperative mortality and morbidity among 50 patients who underwent reinforcement of PJ anastomosis using PGA mesh and fibrin glue were compared with 78 patients (historical controls).


RESULTS
The 2 groups demonstrated no significant differences in frequencies of overall or septic complications, reoperation, or in-hospital death. No significant difference in the frequency of POPF, delayed gastric emptying, or intra-abdominal abscess was found between groups. There was no difference between the 2 groups in the number of necessary interventions, and no bleeding complications or POPF-related mortality occurred. The median length of postoperative in-hospital stay between the 2 groups was similar: 13 days (range, 8-101 days) versus 14 days (range, 8-61 days). Similar findings were observed in a subgroup analysis consisting of patients with a pancreatic duct diameter smaller than 3 mm.


CONCLUSIONS
This retrospective single-center study showed that reinforcement of PJ anastomosis using PGA mesh and fibrin glue provided no significant benefit in reducing the frequency of POPF.
Satoi
Sohei
S
Department of Surgery, Kansai Medical University, Osaka, Japan. satoi@hirakata.kmu.ac.jp
Toyokawa
Hideyoshi
H
Yanagimoto
Hiroaki
H
Yamamoto
Tomohisa
T
Hirooka
Satoshi
S
Yui
Rintaro
R
Yamaki
So
S
Matsui
Yoichi
Y
Mergental
Hynek
H
Kwon
A-Hon
AH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008136:Longevity; D008297:Male; D008875:Middle Aged; D010193:Pancreaticojejunostomy / Q000379:methods*; D011100:Polyglycolic Acid / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies; D013526:Surgical Mesh
D015718:Fibrin Tissue Adhesive; D011100:Polyglycolic Acid