Clonality analysis of giant cell lesions of the jaws.
Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions.
Amaral
Fabrício Rezende
FR
Department of Oral Surgery and Pathology, Dental School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. fabricioramaral@superig.com.br
Gomes
Carolina Cavaliéri
CC
Oliveira
Carla Silveira
CS
Souza
Paulo Eduardo Alencar de
PE
Gomez
Ricardo Santiago
RS
D041321:Chromosomes, Human, X; D002999:Clone Cells / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008339:Mandibular Neoplasms / Q000235:genetics / Q000473:pathology*; D008441:Maxillary Neoplasms / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction / Q000379:methods; D011944:Receptors, Androgen / Q000235:genetics
D004273:DNA, Neoplasm; D011944:Receptors, Androgen