Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span.
Accumulating evidence from various organisms points to a role for autophagy in the regulation of life span. By performing a genome-wide screen to identify novel life span determinants in Saccharomyces cerevisiae, we have obtained further insights into the autophagy-related and -unrelated degradation processes that may be important for preventing cellular senescence. The generation of multivesicular bodies and their fusion with the vacuole in the endosomal pathway emerged as novel cell functions involved in yeast chronological survival and longevity extension.
Longo
Valter D
VD
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Nislow
Corey
C
Fabrizio
Paola
P
D001343:Autophagy / Q000235:genetics*; D031204:Caloric Restriction; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics*; D005820:Genetic Testing; D009154:Mutation / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics* / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D056827:Endosomal Sorting Complexes Required for Transport; D029701:Saccharomyces cerevisiae Proteins