Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study).
BACKGROUND
The management of cardiovascular risk factors is important for prevention of atherosclerotic cardiovascular diseases (ACVD). Visceral fat accumulation plays an important role in the clustering of cardiovascular risk factors, leading to ACVD. The present study investigated the gender- and age-specific relationship between obesity-related cardiovascular risk factor accumulation and computed tomography (CT)-measured fat distribution in a large-scale Japanese general population.


RESULTS
Fat distribution was measured on CT scans in 12,443 subjects (males/females = 10,080/2,363), who underwent medical health check-up at 9 centers in Japan. The investigated obesity-related cardiovascular risk factors were hyperglycemia, dyslipidemia, and elevated blood pressure. Visceral fat area (VFA) for all males and old females showed almost symmetric distribution, while that of young females showed skewed distribution with a marked left shift. Only a small proportion of young females had large visceral fat and cardiovascular risk accumulation. The mean number of risk factors exceeded 1.0 at around 100 cm(2) for VFA in all groups, irrespective of gender, age (cut-off age 55), and BMI (cut-off BMI 25 kg/m(2)).


CONCLUSIONS
In this large-scale Japan-wide general population study, an absolute VFA value of about 100 cm(2) equated with obesity-related cardiovascular risk factor accumulation, irrespective of gender, age, and BMI.
Hiuge-Shimizu
Aki
A
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Kishida
Ken
K
Funahashi
Tohru
T
Ishizaka
Yuko
Y
Oka
Rie
R
Okada
Minoru
M
Suzuki
Shizu
S
Takaya
Norihide
N
Nakagawa
Tohru
T
Fukui
Toshiki
T
Fukuda
Hiroshi
H
Watanabe
Naoya
N
Yoshizumi
Tohru
T
Nakamura
Tadashi
T
Matsuzawa
Yuji
Y
Yamakado
Minoru
M
Shimomura
Iichiro
I
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D050197:Atherosclerosis / Q000209:etiology*; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D050151:Subcutaneous Fat / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D055815:Young Adult