Thymic egress: S1P of 1000.
Recent studies have begun to illuminate the mechanism of T-cell export from the thymus, with the identification of a required lysophospholipid receptor, two upstream transcription factors, and several downstream regulators of cytoskeleton dynamics. This work has generated immediate translational impact, aiding the design of immunosuppressant drugs and the identification of a novel form of human immunodeficiency.
Zachariah
Marcus A
MA
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco 513 Parnassus Avenue, San Francisco, CA 94143 USA.
Cyster
Jason G
JG