Klinefelter syndrome presenting as behavioral problems in a young adult.
BACKGROUND
An 18-year-old Somali man presented to a primary care clinic to investigate a potential pathophysiological reason for behavioral problems at school that had arisen in the past 1-2 years. A previous physical examination at school revealed the patient to have small, firm testicles which prompted further testing.


METHODS
Thyroid function and levels of prolactin, total testosterone, follicle-stimulating hormone and luteinizing hormone were determined. Testes were measured. Chromosome analysis testing was performed to determine the patient's karyotype.


METHODS
Klinefelter syndrome with a 47,XXY karyotype.


RESULTS
Testosterone replacement therapy was recommended, but the patient declined treatment.
Molnar
Alexandra M
AM
International Medicine Clinic, Harborview Medical Center, Box 359895, 325 9th Avenue, Seattle, WA 98104, USA. amolnar@u.washington.edu
Terasaki
Genji S
GS
Amory
John K
JK
D000293:Adolescent; D041321:Chromosomes, Human, X; D003937:Diagnosis, Differential; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications / Q000175:diagnosis*; D007859:Learning Disabilities / Q000175:diagnosis / Q000209:etiology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology; D012729:Sex Chromosome Aberrations; D014314:Trisomy / Q000175:diagnosis; D055815:Young Adult