Geographical variation in human papillomavirus prevalence in Mexican women with normal cytology.
OBJECTIVE
To determine the prevalence of human papillomavirus (HPV) infection and genotype distribution in Mexican women with similar lifestyles from two geographical regions who receive medical care from the Mexican Navy Health System, and to identify the associated sociodemographic and reproductive characteristics.


METHODS
Cervical swabs from 671 women, beneficiaries of the Mexican Navy Health System, from two distinct southern coast regions of Mexico, were analyzed. Data were obtained regarding sociodemographic variables and sexual and reproductive history. For HPV detection and typing, PCR with general primers and direct sequencing were performed on extracted DNA. Association with clinical variables was evaluated.


RESULTS
Most patients had a normal cytology or low-grade intraepithelial neoplasia. A high prevalence of HPV was found (43.6%), with a significant difference between the two regions studied from the southwest Pacific coast of Mexico (37.6% in Acapulco, Guerrero vs. 49.7% in Lázaro Cárdenas, Michoacán). Some differences were also found associated to HPV type distribution, particularly related to genotypes 18, 58, and 53. Factors influencing these differences could not be identified with the analysis of typical risk factors linked to the acquisition of an HPV infection.


CONCLUSIONS
Regional differences in HPV prevalence and distribution show an apparent geographic boundary between the studied populations that deserves further analysis, taking into account other factors such as those related to the sexual partners.
Orozco-Colín
Asunción
A
Dirección General Adjunta de Sanidad Naval, Secretaría de Marina, Mexico.
Carrillo-García
Adela
A
Méndez-Tenorio
Alfonso
A
Ponce-de-León
Sergio
S
Mohar
Alejandro
A
Maldonado-Rodríguez
Rogelio
R
Guerra-Arias
Rocío
R
Flores-Gil
Octavio
O
Sotelo-Regil
Rita
R
Lizano
Marcela
M
D000328:Adult; D002584:Cervix Uteri / Q000166:cytology* / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D012747:Sexual Partners; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology
D004279:DNA, Viral