External globus pallidus stimulation modulates brain connectivity in Huntington's disease.
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.
Ligot
Noémie
N
Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. nligot@ulb.ac.be
Krystkowiak
Pierre
P
Simonin
Clémence
C
Goldman
Serge
S
Peigneux
Philippe
P
Van Naemen
John
J
Monclus
Michel
M
Lacroix
Simon Frédéric
SF
Devos
David
D
Dujardin
Kathy
K
Delmaire
Christine
C
Bardinet
Eric
E
Delval
Arnaud
A
Delliaux
Marie
M
Defebvre
Luc
L
Yelnik
Jerome
J
Blond
Serge
S
Destée
Alain
A
De Tiège
Xavier
X
D000328:Adult; D001479:Basal Ganglia / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D046690:Deep Brain Stimulation; D005260:Female; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography; D013788:Thalamus / Q000502:physiology
D010104:Oxygen Radioisotopes