Oral repeat dose and reproductive toxicity of the chlorinated flame retardant Dechlorane Plus.
This study consisted of a 28-day oral repeat dose (repeat dose toxicity [RDT]) phase and a developmental and reproductive (developmental and reproductive toxicity [DART]) phase with rats. Rats were treated with Dechlorane Plus at doses of 0, 750, 1500, or 5000 mg/kg by gavage. For the RDT phase, no effects were observed on in-life parameters or clinical or anatomic pathology. In the DART phase, no effects were observed on reproductive or fertility indices, or fetal development through lactation day (LD) 4. No effects were noted on gestation day (GD) 20 implantation data, fetal indices, or external and visceral examinations. Mortalities occurred across all dose groups, although these were gavage-related errors and not compound related. Microscopic evidence of gavage-related errors included adhesions, inflammation, and fibrosis in the thoracic and pleural cavities. These findings were not test article related as they were observed only in animals with evidence of gavage injury. The no-observable-effect level (NOEL) in both phases of study was 5000 mg/kg.
Brock Scientific Consulting, 19909 Hamil Cir., Montgomery Village, MD, 20886, USA. billbrock@comcast.net
William J
WJ
Brock
Raymond E
RE
Schroeder
Christy A
CA
McKnight
Jan L
JL
VanSteenhouse
Janice M
JM
Nyberg
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005411:Flame Retardants / Q000008:administration & dosage / Q000633:toxicity*; D006843:Hydrocarbons, Chlorinated / Q000008:administration & dosage / Q000633:toxicity*; D007774:Lactation; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D020258:Neurotoxicity Syndromes; D019055:No-Observed-Adverse-Effect Level; D018812:Paternal Exposure / Q000009:adverse effects; D011083:Polycyclic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity
D005411:Flame Retardants; D006843:Hydrocarbons, Chlorinated; D011083:Polycyclic Compounds; D013723:Teratogens; C526360:dechlorane plus