The effects of parity, breastfeeding, and infertility treatment on the risk of hereditary breast and ovarian cancer: a review.
Knowledge of the potential association of parity, breastfeeding, and infertility treatment on breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers is important and should be a crucial part of genetic counseling. The discussion of parity and clinical management of infertility in these women is complex, and patient preferences should be considered. Ideally, these preferences should be informed by accurate information on the risks and benefits of the interventions considered. However, this important subject has been investigated in a relatively small number of studies, thus, the existing data remain somewhat limited, and the estimated risk of cancer in BRCA mutation carriers is imprecise.
Fishman
Ami
A
Department of Obstetrics and Gynecology, Meir Medical Center, Kfar-Saba, Israel. amifishman@gmail.com
D001942:Breast Feeding; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics*; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors