Hemangioblastomas might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche.
The cytological origin of central nervous system hemangioblastoma (HB) remains unclear and controversial, largely owing to a lack of in-depth characterization of tumorigenic cells and their progeny tracking. We have now detected a cell subpopulation by stage-specific embryonic antigen-1 expression, which were defined as tumor-initiating cells (TICs) in both sporadic and familial HBs. These TICs subpopulations had universal neural stem cell characteristics. Nevertheless, the freshly sorted TICs endowed with potential of multi-progeny derivatives, including HB components and non-HB ingredients, depended on environmental induction in vitro. Importantly, the freshly harvested TICs formed malignant tumors by injection into conventional mice model, while did redevelop the characteristic HB-like structures within a special mice model with HB-microenvironment, indicating HB niche dependency for the TICs derivative specification. Taken together, the data of the present study suggested that HBs might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche.
Ma
Dexuan
D
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Zhang
Minmin
M
Chen
Luping
L
Tang
Qisheng
Q
Tang
Xuqun
X
Mao
Ying
Y
Zhou
Liangfu
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D015153:Blotting, Western; D002454:Cell Differentiation; D019070:Cell Lineage; D002469:Cell Separation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D018325:Hemangioblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016256:Lewis X Antigen / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism; D058953:Neural Stem Cells / Q000378:metabolism / Q000473:pathology*; D055153:Stem Cell Niche / Q000166:cytology; D055815:Young Adult
D016256:Lewis X Antigen