FIH1 (factor inhibiting HIF-1) in the kidney: more than an oxygen sensor?
Factor inhibiting HIF-1 (FIH1) inhibits the activity of hypoxia-inducible factor 1 (HIF-1) by preventing HIF-1α from binding to p300/CBP. Schödel et al. demonstrate that, in the kidney, FIH1 is expressed selectively in the distal tubules and podocytes. Although FIH1 functions as a transcriptional repressor of HIF target genes in tubular cells, it does not do so in podocytes. This study suggests that FIH1 may have diverse implications for distal tubular function and podocyte biology.
Sirin
Yasemin
Y
Medizinische Klinik und Poliklinik D, University of Münster, Münster, Germany.
Pavenstädt
Hermann
H
D000818:Animals; D015687:Cell Hypoxia; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D015432:Glomerulonephritis, Membranoproliferative / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000378:metabolism*; D051379:Mice; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D050199:Podocytes / Q000378:metabolism*; D051381:Rats; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D050880:p300-CBP Transcription Factors / Q000378:metabolism
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012097:Repressor Proteins; D006899:Mixed Function Oxygenases; C551240:factor inhibiting hypoxia-inducible factor 1, mouse; C439790:HIF1AN protein, human; D050880:p300-CBP Transcription Factors; D010100:Oxygen