Bacterial population genomics and infectious disease diagnostics.
New sequencing technologies have made the production of bacterial genome sequences increasingly easy, and it can be confidently forecasted that vast genomic databases will be generated in the next few years. Here, we detail how collections of bacterial genomes from a particular species (population genomics libraries) have already been used to improve the design of several diagnostic assays for bacterial pathogens. Genome sequencing itself is also becoming more commonly used for epidemiological, forensic and clinical investigations. There is an opportunity for the further development of bioinformatic tools to bring even further value to bacterial diagnostic genomics.
Joseph
Sandeep J
SJ
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.
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Timothy D
TD
D001419:Bacteria / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000175:diagnosis*; D001431:Bacteriological Techniques / Q000379:methods*; D044822:Biodiversity; D019295:Computational Biology / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D054892:Metagenome; D025202:Molecular Diagnostic Techniques / Q000379:methods*