The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease.
The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-year prognostic risk of acute myocardial infarction (fatal and non-fatal) and sudden death, with the respect of secondary CHD prevention. It has been demonstrated that 12-month treatment with Allicor results in the significant decrease of cardiovascular risk by 1.5-fold in men (p < 0.05), and by 1.3-fold in women. The above results were equitable also in terms of relative risks. The main effect that played a role in cardiovascular risk reduction was the decrease in LDL cholesterol by 32.9 mg/dl in men (p < 0.05), and by 27.3 mg/dl in women. Thus, the most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a trend that might be due presumably to the insufficient sample size. Since Allicor is the remedy of natural origin, it is safe with the respect to adverse effects and allows even perpetual administration that may be crucial for the secondary prevention of atherosclerotic diseases in CHD patients.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia. sobenin@cardio.ru
Igor A
IA
Sobenin
Valentin V
VV
Pryanishnikov
Lyudmila M
LM
Kunnova
Yevgeny A
YA
Rabinovich
Danik M
DM
Martirosyan
Alexander N
AN
Orekhov
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013607:Tablets / Q000627:therapeutic use*; D016896:Treatment Outcome
D000975:Antioxidants; D008078:Cholesterol, LDL; D013607:Tablets