Overcoming obstacles to developing new analgesics.
Despite substantial investment by the pharmaceutical industry over several decades, there has been little progress in developing new, efficacious and safe analgesics. As a result, many large pharmaceutical companies are leaving the area of pain medication. Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging.
Neurobiology Center and Program in Neurobiology, Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, USA. clifford.woolf@childrens.harvard.edu
Clifford J
CJ
Woolf
D000700:Analgesics / Q000191:economics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D017277:Drug Approval; D055808:Drug Discovery; D006801:Humans; D040541:Marketing; D010330:Patents as Topic; D010820:Physicians; D015203:Reproducibility of Results
D000700:Analgesics