A new translocation between chromosomes 6 and 9 helps to establish diagnosis of renal oncocytoma.
Renal oncocytomas are benign epithelial tumors of the kidney. Histologically, they resemble certain malignant renal tumors, such as chromophobe renal cell carcinoma and the eosinophilic or granular form of clear cell renal carcinoma. It is, therefore, important to be able to differentiate among these tumors. Cytogenetic analysis is an important adjunct to the diagnosis of renal tumors, as the various subtypes have specific acquired chromosome abnormalities. Oncocytomas present either with loss of chromosome 1 and a sex chromosome, or with recurring translocations involving chromosome 11. We describe 2 patients with renal oncocytoma and a new translocation between chromosomes 6 and 9. The tumors in both patients were histologically virtually identical. The t(6;9)(p21;p23) may be a new translocation associated with renal oncocytomas.
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, NJ 08903, USA.
Rachel
R
Hudacko
Michael
M
May
Hana
H
Aviv
D018249:Adenoma, Oxyphilic / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D000328:Adult; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured