Enantioselective synthesis of the lomaiviticin aglycon full carbon skeleton reveals remarkable remote substituent effects during the dimerization event.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
Hong Geun
HG
Lee
Jae Young
JY
Ahn
Amy S
AS
Lee
Matthew D
MD
Shair
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D000095602:Angucyclines and Angucyclinones
D000903:Antibiotics, Antineoplastic; D005449:Fluorenes; C433842:lomaiviticin A; D000095602:Angucyclines and Angucyclinones; C433843:lomaiviticin B