[TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease].
OBJECTIVE
To study the association between single nucleotide polymorphisms of thioredoxin reductase-2 (TrxR2) gene and the susceptibility to Kashin-Beck disease (KBD).


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotype frequencies of rs5748469 in TrxR2 gene in 84 KBD patients and 109 healthy control subjects.


RESULTS
The genotype frequencies of A/A, A/C, and C/C in the KBD patients were 83.33%, 15.48% and 1.19%, as compared with the frequencies of 74.31%, 25.69%, and 0.00% in the healthy control, respectively, showing no significant difference in the single nucleotide polymorphisms of TrxR2 gene between the two groups (P=0.13).


CONCLUSIONS
No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to KBD.
School of Life Science and Technology, Xi'an Jiaotong University, College of Medicine, Xi'an 710049, China. luwei@stu.xjtu.edu.cn
Wei
W
Lu
Xiao-yan
XY
Mo
Yong-min
YM
Xiong
D000328:Adult; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D057767:Kashin-Beck Disease / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054482:Thioredoxin Reductase 2 / Q000235:genetics*
C516127:TXNRD2 protein, human; D054482:Thioredoxin Reductase 2