APOE genetic associations with seizure development after severe traumatic brain injury.
OBJECTIVE
The purpose of the current study is to assess the role of the APOE genotype in post-traumatic seizure (PTS) development.


METHODS
A retrospective study of 322 adult Caucasians with a severe TBI and APOE genotype.


METHODS
Medical records were searched for PTS. Time to first seizure was categorized as early, late or delayed-onset PTS. Potential PTS associations by genotype, grouped genotype and allele were investigated.


RESULTS
No statistically significant associations were found. However, two out of the four individuals (50%) with the E4/E4 genotype had late/delayed-onset PTS. Furthermore, none with a E2/E2 or E2/E4 genotype seized in the late periods.


CONCLUSIONS
The results of this study may suggest 4/4 as a risk genotype for late/delayed onset PTS and a potential neuroprotective role of the E2 allele. However, this study did not definitively support a role for the APOE genotype in PTS susceptibility and indicates that larger populations are needed to fully evaluate the potential impact of APOE on PTS.
Miller
Megan A
MA
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Conley
Yvette
Y
Scanlon
Joelle M
JM
Ren
Dianxu
D
Ilyas Kamboh
M
M
Niyonkuru
Christian
C
Wagner
Amy K
AK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D004834:Epilepsy, Post-Traumatic / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000235:genetics*; D055815:Young Adult
D001057:Apolipoproteins E