Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair.
Mice deficient in classical major histocompatibility complex class I (MHCI) have aberrations in neurodevelopment. The consequences of upregulated neuronal MHCI expression have not been examined. We found that transgenic C57Bl/6 mice that are engineered to express higher levels of self-D(b) on their CNS neurons have alterations in their hippocampal morphology and retinogeniculate projections, as well as impaired neurorepair responses. Thus, enhanced neuronal classical MHCI expression can lead to aberrations in neural circuitry and neurorepair. These findings complement a growing body of knowledge concerning the neurobiological activities of MHCI and may have potential clinical relevance.
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Zhongqi-Phyllis
ZP
Wu
Lorraine
L
Washburn
Tina V
TV
Bilousova
Maia
M
Boudzinskaia
Nathalie
N
Escande-Beillard
Jyes
J
Querubin
Hoa
H
Dang
Cui-Wei
CW
Xie
Jide
J
Tian
Daniel L
DL
Kaufman
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009416:Nerve Regeneration / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009924:Organ Culture Techniques; D009435:Synaptic Transmission / Q000502:physiology
D015395:Histocompatibility Antigens Class I; D000110:Acetylcholinesterase