New phenylpropanoids and in vitro α-glucosidase inhibitors from Balanophora japonica.
Five new phenylpropanoids, named balajaponins A-E (1-5), were isolated from Balanophora japonica, along with 24 known compounds. Among them, three hydrolysable tannins (6-8) showed specific in vitro α-glucosidase inhibition, with IC₅₀ values in the range of 1-4 µM. Kinetic analysis revealed that they all acted in a noncompetitive mode.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Tong
T
Zhou
Xiao-hui
XH
Zhang
Shu-wei
SW
Zhang
Shan-shan
SS
Liu
Li-jiang
LJ
Xuan
D031111:Balanophoraceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000378:metabolism
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D047348:Hydrolyzable Tannins; D010666:Phenylpropionates; D010936:Plant Extracts; D000520:alpha-Glucosidases