The effect of tigecycline and ertapenem against clinical isolates of Brucella melitensis detected by E-test on different media.
In this study, in vitro activity of tigecycline (TIG) and ertapenem (ERT) against clinical isolates of Brucella melitensis and the effect of different media on in vitro test results were investigated. The in vitro effects of TIG and ERT to 38 B. melitensis isolates were comparatively investigated in brucella agar and 5% sheep blood agar. MIC value of ERT was 0.032 μg/mL in 23 of 38 and 20 of 38 isolates on blood and brucella agar, respectively. Minimum inhibitory concentration values of TIG were substantially different ranging between 0.064-0.25 μg/mL on blood agar. However, MIC values of TIG were similar on brucella agar with 0.25 μg/mL in 15 of 38 isolates and 0.5 μg/mL in 10 of 38 isolates. In conclusion, although ERT and TIG were effective against B. melitensis isolates in vitro, further studies are needed in order to determine the use of these novel drugs in treatment of brucellosis.
Department of Clinical Microbiology and Infectious Diseases, Ondokuz Mayis University, Medical School, Samsun, Turkey. estanyel@yahoo.com.tr
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Tanyel
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Coban
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Fisgin
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Tulek
D000362:Agar; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001769:Blood; D017347:Brucella melitensis / Q000187:drug effects* / Q000302:isolation & purification; D002006:Brucellosis / Q000382:microbiology; D003470:Culture Media / Q000737:chemistry*; D000077727:Ertapenem; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D012756:Sheep; D000078304:Tigecycline; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D047090:beta-Lactams; D000078304:Tigecycline; D000362:Agar; D008911:Minocycline; D000077727:Ertapenem