Increased immunoreactivity to SLIT/ROBO1 and its correlation with severity of dysmenorrhea in adenomyosis.
Compared with normal endometrium, SLIT expression was statistically significantly higher in ectopic endometrium from women with adenomyosis, while roundabout 1 (ROBO1) immunoreactivity and microvessel density (MVD) level were statistically significantly higher in both eutopic and ectopic endometrium than normal endometrium. Both SLIT immunoreactivity in ectopic endometrium and MVD in eutopic endometrium were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity in women with adenomyosis.
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China.
Jichan
J
Nie
Xishi
X
Liu
Yu
Y
Zheng
Jian-Guo
JG
Geng
Sun-Wei
SW
Guo
D015415:Biomarkers / Q000378:metabolism; D004412:Dysmenorrhea / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011237:Predictive Value of Tests; D011971:Receptors, Immunologic / Q000378:metabolism*; D012720:Severity of Illness Index; D000097905:Roundabout Proteins
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C492289:SLIT1 protein, human