Biomagnetic methods: technologies applied to pharmaceutical research.
Biomagnetic methods have been designed for a wide range of applications. Recently, such methods have been proposed as alternatives to scintigraphy for evaluating of a number of pharmaceutical processes in vitro as well as under the influence of gastrointestinal physiological parameters. In this review, physical characterization as well as the most recent applications of Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) in the pharmaceutical research will be explored. Moreover, their current status and how these technologies can be employed to improve the knowledge about the impact of gastrointestinal physiology on drug delivery in association with pharmacokinetic outcomes, termed pharmacomagnetography, will be presented.
Corá
Luciana A
LA
Pró-Reitoria de Pesquisa e Pós-Graduação, Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brazil.
Américo
Madileine F
MF
Oliveira
Ricardo B
RB
Serra
Cristina H R
CH
Baffa
Oswaldo
O
Evangelista
Raul C
RC
Oliveira
Giselle F
GF
Miranda
José Ricardo Aruda
JR
D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D008280:Magnetics / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000032:analysis; D013678:Technology, Pharmaceutical / Q000379:methods*
D004364:Pharmaceutical Preparations