Uric acid as a marker of oxidative stress in dilatation of the ascending aorta.
BACKGROUND
Increased serum uric acid (UA) has been shown to directly promote oxidative stress. Recent studies point toward a role for oxidative stress in the pathogenesis of ascending aortic aneurysms (AscAAs). This study was designed to examine the relationship between serum UA concentrations, total antioxidant reductive capacity, and AscAAs.


METHODS
The serum UA concentrations, total antioxidant reductive capacity were compared in 60 patients with ascending aortic dilatation (ectasia group (3.8-4.3 cm), 34 patients; aneurysmal group (≥4.4 cm), 26 patients) vs. 30 control subjects. The patients were evaluated by a complete transthoracic echocardiographic examination including measurement of the aortic dimensions.


RESULTS
The serum UA concentration and total antioxidant reductive capacity were significantly higher in patients with AscAAs. In multiple linear regression analysis, hypertension and serum UA concentration were significantly associated with aortic dilatation (β = 0.3, P = 0.03; β = 0.15, P < 0.001, respectively).


CONCLUSIONS
In conclusion, we found that serum UA concentration and total antioxidant capacity (TAC) were significantly associated with aortic dilatation. The higher serum UA concentration may be responsible for the elevated serum antioxidant capacity that was observed among individuals with AscAA. Large-scale epidemiological studies conducted over several years are required to correlate the cross-sectional findings from this study with clinical outcome.
Esen
Ali M
AM
Kartal Kosuyolu Heart-Education and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Akcakoyun
Mustafa
M
Esen
Ozlem
O
Acar
Goksel
G
Emiroglu
Yunus
Y
Pala
Selcuk
S
Kargin
Ramazan
R
Karapinar
Hekim
H
Ozcan
Omer
O
Barutcu
Irfan
I
D000328:Adult; D000368:Aged; D001011:Aorta / Q000000981:diagnostic imaging / Q000473:pathology*; D001014:Aortic Aneurysm / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D018570:Risk Assessment; D012307:Risk Factors; D014421:Turkey; D014463:Ultrasonography; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid