Healing genes in the nervous system.
The evolution of gene therapy has led to the development of promising new therapeutic approaches. This NeuroView will introduce the variety of delivery vehicles currently available for gene therapy, a range of preclinical strategies for tackling major diseases of the nervous system, the clinical limitations, and ethical considerations.
Breakefield
Xandra O
XO
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. breakefield@hms.harvard.edu
Sena-Esteves
Miguel
M
D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009420:Nervous System / Q000378:metabolism*; D009422:Nervous System Diseases / Q000235:genetics / Q000473:pathology / Q000628:therapy