Porcine dermal collagen matrix injection may enhance flap repair surgery for complex anal fistula.
BACKGROUND
The use of biomaterials to treat anal fistula has drawn great interest. More recently, a porcine dermal matrix injection has been proposed as infill biomaterial to treat fistulas.


METHODS
We propose a novel approach consisting in non-cutting seton positioning followed by flap repair associated with dermal matrix injection into the fistula tracts after several weeks.


RESULTS
We report our experience with this two-staged procedure on 11 consecutive patients with recurrent high trans-sphincteric fistulas with a minimum follow-up of 6 months.


CONCLUSIONS
In our experience, this two-stage approach seems to be safe and effective.
Department of Surgery, University of Rome Tor Vergata, Policlinico Tor Vergata, Chirurgia Generale, Viale Oxford 81, 00133 Rome, Italy. piersileri@yahoo.com
Pierpaolo
P
Sileri
Luana
L
Franceschilli
Giovanna
G
Del Vecchio Blanco
Vito M
VM
Stolfi
Giulio P
GP
Angelucci
Achille L
AL
Gaspari
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003094:Collagen / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D020405:Dermis / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D012003:Rectal Fistula / Q000601:surgery*; D013524:Surgical Flaps; D034421:Sus scrofa; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
D003094:Collagen