Regulation of major histocompatibility complex class II genes.
The major histocompatibility complex class II (MHC-II) genes are regulated at the level of transcription. Recent studies have shown that chromatin modification is critical for efficient transcription of these genes, and a number of chromatin modifying complexes recruited to MHC-II genes have been described. The MHC-II genes are segregated from each other by a series of chromatin elements, termed MHC-II insulators. Interactions between MHC-insulators and the promoters of MHC-II genes are mediated by the insulator factor CCCTC-binding factor and are critical for efficient expression. This regulatory mechanism provides a novel view of how the entire MHC-II locus is assembled architecturally and can be coordinately controlled.
Department of Microbiology & Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, United States.
Nancy M
NM
Choi
Parimal
P
Majumder
Jeremy M
JM
Boss
D000818:Animals; D002875:Chromosomes; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D011401:Promoter Regions, Genetic
D000949:Histocompatibility Antigens Class II; D006657:Histones