Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation.
Uveitis is an intraocular inflammatory disease causing a significant visual impairment. The disease can be idiopathic, associated with infectious and systemic disorders or arisen from an unknown cause. Over the last 20years the model of EAU in mice has contributed significantly for the establishment of parameters for diagnostic evaluations and therapies for posterior uveitis in human. Many studies using recently discovered molecules which present proinflammatory and anti-inflammatory effects have been described. Moreover, new approaches of research provided by the increasing body of knowledge on components of immune responses such as cytokines, T-cell subpopulations and their associated functions have contributed for the further understanding of uveitis and possible treatment.
Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, São Paulo, Brazil.
Alessandra Goncalves
AG
Commodaro
Valquiria
V
Bueno
Rubens
R
Belfort
Luiz Vicente
LV
Rizzo
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D056747:Immunomodulation / Q000187:drug effects / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D011409:Propylene Glycols / Q000494:pharmacology; D013110:Sphingosine / Q000031:analogs & derivatives / Q000494:pharmacology; D014605:Uveitis / Q000276:immunology*
D007155:Immunologic Factors; D018836:Inflammation Mediators; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine