The talin FERM domain is not so FERM.
The structure of the head domain of talin, an intracellular activator of integrin membrane adhesion receptors, has been solved by Elliott et al. (2010). A FERM domain can be identified in the head from sequence comparisons but, rather than having a compact structure of three subdomains, it has linear arrangement of four subdomains.
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. iain.campbell@bioch.ox.ac.uk
Iain D
ID
Campbell