[Biological effects of phytoecdysteroids and chronic low-dose irradiation].
The influence of serpistene in dose of 5 and 50 mg/kg on chronic low-dose gamma-irradiation (22.6 cGy) effects on cytogenetic (abnormal sperm cell, marrow bone micronucleus) and function and morphology (thyroid and adrenal glands) parameters of mice was estimated. The serpistene modifies effects of gamma-irradiation depends on the administration regime and a dose of the substance. The most expressive radioprotective effect on endocrine organs after serpistene prophylactic administration was found. The prophylactic dose was 5 mg/kg for adrenal gland and both doses--for thyroid gland. The most expressive radioprotective effect on marrow bone cells after serpistene therapeutic administration in a dose of 5 mg/kg was found. The most expressive antimutagenic effect on somatic and germinal cells of prophylactic and therapeutic administration in a dose of 50 mg/kg was found.
Raskosha
O V
OV
Bashlykova
L A
LA
Ermakova
O V
OV
D000302:Adrenal Cortex / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D026461:Ecdysteroids / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D020964:Embryo Loss / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D012098:Reproduction / Q000187:drug effects / Q000528:radiation effects; D013077:Sperm Head / Q000187:drug effects / Q000528:radiation effects; D013737:Testis / Q000187:drug effects / Q000528:radiation effects; D013961:Thyroid Gland / Q000187:drug effects / Q000528:radiation effects
D026461:Ecdysteroids; D011837:Radiation-Protective Agents