Increased immunoreactivity to SLIT/ROBO1 and its correlation with severity of dysmenorrhea in adenomyosis.
Compared with normal endometrium, SLIT expression was statistically significantly higher in ectopic endometrium from women with adenomyosis, while roundabout 1 (ROBO1) immunoreactivity and microvessel density (MVD) level were statistically significantly higher in both eutopic and ectopic endometrium than normal endometrium. Both SLIT immunoreactivity in ectopic endometrium and MVD in eutopic endometrium were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity in women with adenomyosis.
Nie
Jichan
J
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China.
Liu
Xishi
X
Zheng
Yu
Y
Geng
Jian-Guo
JG
Guo
Sun-Wei
SW
D015415:Biomarkers / Q000378:metabolism; D004412:Dysmenorrhea / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011237:Predictive Value of Tests; D011971:Receptors, Immunologic / Q000378:metabolism*; D012720:Severity of Illness Index; D000097905:Roundabout Proteins
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C492289:SLIT1 protein, human