Cancer transmissibility across HLA barriers between immunocompetent individuals: rare but not impossible.
The axiom of human leukocyte incompatibility (HLA) incompatibility has always led scientists to consider cancer transmission between HLA-different individuals impossible. In fact, cancer transmission between individuals represents a frightening possibility in animal populations with limited HLA diversity or for rare cancers exploiting downregulation of HLA expression. We review here evidence from nonhuman models and settings for interhuman transmission.
Focosi
Daniele
D
Laboratory of Immunogenetics, Division of Immunohematology, Azienda Ospedaliera Universitaria Pisana, Italy. dfocosi@tin.it
De Donno
Monica
M
Barbuti
Serena
S
Davini
Sara
S
Fornaciari
Silvia
S
Curcio
Michele
M
Mariotti
Maria Luciana
ML
Scatena
Fabrizio
F
D000818:Animals; D001803:Blood Transfusion; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence / Q000276:immunology*; D009369:Neoplasms / Q000453:epidemiology / Q000276:immunology* / Q000601:surgery; D014180:Transplantation; D014685:Venereal Tumors, Veterinary / Q000453:epidemiology / Q000276:immunology*
D015395:Histocompatibility Antigens Class I