In vivo neurochemistry of primary focal hand dystonia: a magnetic resonance spectroscopic neurometabolite profiling study at 3T.
The neurochemical basis of dystonia is unknown. The purpose of this study was to assess the differences of the inhibitory neurotransmitter, gamma amino butyric acid (GABA), in the sensorimotor cortex and the basal ganglia using magnetic resonance spectroscopy with optimized GABA sensitivity. Twenty-two patients with focal hand dystonia and 22 healthy controls were studied. No significant differences in GABA were observed between the groups in either the sensorimotor cortex or in the basal ganglia.
Medical Neurology Branch, Human Motor Control Section, NINDS/NIH, Bethesda, Maryland, USA. herapx@gmail.com
Priyantha
P
Herath
Cecile
C
Gallea
Jan Willem
JW
van der Veen
Silvina G
SG
Horovitz
Mark
M
Hallett
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000378:metabolism* / Q000473:pathology; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D020821:Dystonic Disorders / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D009465:Neuromuscular Agents; D005680:gamma-Aminobutyric Acid; D019274:Botulinum Toxins, Type A