Chromosome segregation: taking the passenger seat.
The chromosomal passenger complex (CPC) is a major regulator of mitotic and meiotic chromosome segregation. Three recent papers now elucidate the mechanisms that determine the localization of the CPC to the inner centromere.
Vader
Gerben
G
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Lens
Susanne M A
SM
D064127:Aurora Kinases; D002503:Centromere / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D008869:Microtubule-Associated Proteins; D046912:Multiprotein Complexes; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases