Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers.
A novel proton-fueled molecular gate-like delivery system has been constructed for controlled cargo release using i-motif quadruplex DNA as caps onto pore outlets of mesoporous silica nanoparticles. Start from simple conformation changes, the i-motif DNA cap can open and close the pore system in smart response to pH stimulus. Importantly, the opening/closing and delivery protocol is highly reversible and a partial cargo delivery can be easily controlled at will. A pH-switchable nanoreactor has also been developed to validate the potential of our system for on-demand molecular transport. This proof of concept might open the door to a new generation of carrier materials and could also provide a general route to use other functional nucleic acids/peptide nucleic acids as capping agents in the fields of versatile controlled delivery nanodevices.
Chen
Cuie
C
Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
Pu
Fang
F
Huang
Zhenzhen
Z
Liu
Zhen
Z
Ren
Jinsong
J
Qu
Xiaogang
X
D004247:DNA / Q000737:chemistry; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes / Q000032:analysis; D054856:G-Quadruplexes; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011522:Protons; D012235:Rhodamines / Q000032:analysis; D012822:Silicon Dioxide / Q000737:chemistry*
D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D011522:Protons; D012235:Rhodamines; D012822:Silicon Dioxide; D004247:DNA; C029773:rhodamine B