Expression and function of CXCR7 in the mouse forebrain.
The chemokine CXCL12/CXCR4 signaling system is important for the regulation of neuron migration in the developing forebrain. In particular it is crucial for correct distribution of Cajal-Retzius cells and migration of cortical interneurons. Here we investigated the expression of CXCR7, the second receptor for CXCL12, in comparison to CXCR4. We found that shifts in the expression of both receptors in the above cited cell populations coincide with major changes in their migratory behavior. Furthermore, we demonstrated that postnatally generated olfactory interneuron precursors express CXCR7 but not CXCR4 and that their distribution in the rostral migratory stream is affected by CXCR7 downregulation. This suggests an involvement of CXCR7 in neuronal cell migration and indicates a possible action of CXCR7 independently of CXCR4 as a mediator of CXCL12 signaling.
Tiveron
Marie-Catherine
MC
Institut de Biologie du Développement de Marseille Luminy, Unité Mixte de Recherche 6216, CNRS/Université de la Méditerrannée, Campus de Luminy, 13288 Marseile Cedex 09, France.
Boutin
Camille
C
Daou
Pascale
P
Moepps
Barbara
B
Cremer
Harold
H