Successful use of maternal blood in the management of severe hemolytic disease of the fetus and newborn due to anti-Kp(b).
BACKGROUND
The incidence of hemolytic disease of the fetus and newborn (HDFN) has decreased since the introduction of Rh immunoglobulin prophylaxis in Rh(D)-negative pregnant women. Thus, the relative incidence of rare alloantibody-related HDFN has increased. The lack of available maternally matched red blood cells for transfusion in these cases may create management difficulties.


METHODS
We report a case of anti-Kp(b) HDFN. Severe fetal anemia required intrauterine transfusion. Difficulty in obtaining Kp(b)-negative blood necessitated using the mother's donated RBCs.


CONCLUSIONS
Severe HDFN with rare antibodies can be managed successfully using maternal blood.
Bleile
Michelle J
MJ
Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, and University of Iowa, Iowa City, IA 52242, United States.
Rijhsinghani
Asha
A
Department of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, and University of Iowa, Iowa City, IA 52242, United States.
Dwyre
Denis M
DM
Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, and University of Iowa, Iowa City, IA 52242, United States.
Raife
Thomas J
TJ
Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, and University of Iowa, Iowa City, IA 52242, United States. Electronic address: thomas-raife@uiowa.edu.
D001805:Blood Transfusion, Intrauterine / Q000379:methods*; D019468:Disease Management; D004899:Erythroblastosis, Fetal / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D009035:Mothers
D007518:Isoantibodies