Canine invasive lobular carcinoma of the mammary gland: morphological and immunohistochemical characterizations of three cases.
Invasive lobular carcinoma (ILC) represents 15% of invasive human breast tumours. This report describes the morphological and immunohistochemical features of three canine mammary tumours comparable with human ILC. These tumours were composed of a non-delimited proliferation of discrete cells infiltrating fibrous connective tissue. Multifocal in-situ carcinoma associated with invasive lesions was present. Invasive tumour cells and in-situ lesions expressed cytokeratin and CK34betaE12, but not E-cadherin. Based on these morphological and immunohistochemical characteristics, the tumours were classified as canine ILC.
Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Italy. lorenzo.ressel@poste.it
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Ressel
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Millanta
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Poli
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002278:Carcinoma in Situ / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000556:secondary / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D005260:Female; D007633:Keratins / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000378:metabolism / Q000473:pathology*; D015674:Mammary Neoplasms, Animal / Q000378:metabolism / Q000473:pathology*; D008408:Mastectomy / Q000662:veterinary; D009361:Neoplasm Invasiveness
D014408:Biomarkers, Tumor; C121278:CK-34 beta E12; D007633:Keratins