p73 regulates maintenance of neural stem cell.
p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proliferation. In parallel with this in vitro data, the width of the neurogenic areas was reduced in the brains of embryonic and adult p73-/- mice. These data suggest that p73, and in particular TAp73, is important for maintenance of the NSC pool.
Agostini
Massimiliano
M
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.
Tucci
Paola
P
Chen
Hailan
H
Knight
Richard A
RA
Bano
Daniele
D
Nicotera
Pierluigi
P
McKeon
Frank
F
Melino
Gerry
G
D000818:Animals; D049109:Cell Proliferation; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D051379:Mice; D008817:Mice, Mutant Strains; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*; D015854:Up-Regulation
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051880:Receptors, Notch; D055748:SOXB1 Transcription Factors; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins; C454920:delta Np73, mouse