Electrical remodeling in fibrillating canine atrium: action potential alternans during rapid atrial pacing and late phase 3 early afterdepolarization after cessation of rapid atrial pacing.
Sustained atrial fibrillation (AF) was induced by atrial burst pacing, and monophasic action potentials (MAPs) were recorded. MAP alternans was observed at a cycle length (CL) of 167.5 ± 28.2 msec before burst pacing and 201.3 ± 40.2 msec after burst pacing. AF > 5 minutes duration was induced in 1 dog in the control condition but in all 8 dogs after burst pacing. The difference in RA MAPD(80) of the first spontaneous beat and steady-state sinus rhythm was significantly larger after atrial burst pacing than before atrial burst pacing (31.5 ± 15.9 msec versus 8.2 ± 9.0 msec) In 4 dogs, late phase 3 early after depolarization was observed after rapid atrial pacing. Rapid atrial pacing-induced electrical remodeling includes APD alternans during rapid atrial pacing and also causes an increase in the MAPD of the initial several beats and the development of late phase 3 early afterdepolarizations after a sudden increase in CL.
Watanabe
Ichiro
I
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Okumura
Yasuo
Y
Nagashima
Koichi
K
Ohkubo
Kimie
K
Ashino
Sonoko
S
Kofune
Masayoshi
M
Ohya
Toshiyuki
T
Hirayama
Atsushi
A
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000628:therapy; D016275:Atrial Function / Q000502:physiology*; D002304:Cardiac Pacing, Artificial / Q000379:methods; D004285:Dogs; D004554:Electric Countershock; D022062:Electrophysiologic Techniques, Cardiac; D006325:Heart Atria / Q000503:physiopathology*