Focal segmental glomerulosclerosis as a complication of hepatitis B virus infection.
Human hepatitis B virus (HBV) is well known as a cause of membranous nephropathy (MN). While the association of HBV infection with MN is strong, data regarding its association with other glomerular diseases are conflicting. Here, we report a case of focal segmental glomerulosclerosis (FSGS) with HBV infection. In this case, we have found HBV-DNA in urinary podocytes by real-time PCR methods. After the administration of anti-viral therapy, FSGS improved, paralleling the decreased level of HBV-DNA in podocytes. The refractory FSGS induced by HBV could be effectively treated with appropriate anti-viral agents.
Department of Nephrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Kentaro
K
Sakai
Naoki
N
Morito
Joichi
J
Usui
Masahiro
M
Hagiwara
Akira
A
Hiwatashi
Kuniaki
K
Fukuda
Toru
T
Nanmoku
Takayuki
T
Toda
Noriaki
N
Matsui
Michio
M
Nagata
Kunihiro
K
Yamagata
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000235:genetics; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction
D000998:Antiviral Agents; D004279:DNA, Viral