Methadone-induced toxic leukoencephalopathy: diagnosis and follow-up by magnetic resonance imaging including diffusion-weighted imaging and apparent diffusion coefficient maps.
OBJECTIVE
Effects of methadone misuse have been rarely described. The purpose of this case report is to increase the knowledge of methadone-related leukoencephalopathy.


METHODS
We report the long-term follow-up by brain magnetic resonance imaging including isotropic diffusion-weighted imaging and mean apparent diffusion coefficient values of a 49-year-old patient who attempted suicide by intravenous methadone.


CONCLUSIONS
Lesion pattern included subtle cerebellar involvement, mainly reversible extensive bilateral and symmetric brain involvement, cystic degeneration in the periventricular regions, sparing of corpus callosum and subcortical U-fibers, development of diffuse brain atrophy, and clear-cut clinical improvement.
Cerase
Alfonso
A
Dipartimento di Neuroscienze, Azienda Ospedaliera Universitaria Senese, Siena, Italy. alfonsocerase@aliceposta.it
Leonini
Sara
S
Bellini
Matteo
M
Chianese
Giuseppe
G
Venturi
Carlo
C
D001921:Brain / Q000187:drug effects / Q000473:pathology*; D001931:Brain Mapping; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008691:Methadone / Q000506:poisoning*; D008875:Middle Aged
D008691:Methadone