Pulmonary involvement in inflammatory bowel disease.
OBJECTIVE
To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease (IBD).


METHODS
Thirty ulcerative colitis (UC) and nine Crohn's disease patients, and 20 control subjects were enrolled in this prospective study. Detailed clinical information was obtained. Extent and activity of the bowel disease were established endoscopically. Each patient underwent pulmonary function tests and high-resolution computed tomography (HRCT). Blood samples for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), angiotensin converting enzyme and total IgE were delivered by the patients.


RESULTS
Ten (25.6%) patients had respiratory symptoms. A pulmonary function abnormality was present in 22 of 39 patients. Among all patients, the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) 25%-75%, transfer coefficient for carbon monoxide (DLCO), DLCO/alveolar volume. Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients. Endoscopic and clinical activities in UC patients were correlated with FEV1, FEV1/FVC, and FEF 25%-75%. Smoking status, duration of disease and medication were not correlated with pulmonary physiological test results, HRCT abnormalities, clinical/endoscopic disease activity, CRP, ESR or total IgE level or body mass index.


CONCLUSIONS
It is important that respiratory manifestations are recognized and treated early in IBD. Otherwise, they can lead to destructive and irreversible changes in the airway wall.
Atatürk Chest Disease and Chest Surgery Training and Research Hospital, Pulmonary Medicine, 06000 Ankara, Turkey.
Aydin
A
Yilmaz
Nilgün
N
Yilmaz Demirci
Derya
D
Hoşgün
Enver
E
Uner
Yurdanur
Y
Erdoğan
Atila
A
Gökçek
Atalay
A
Cağlar
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D001985:Bronchial Provocation Tests; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011653:Pulmonary Diffusing Capacity; D012846:Singapore; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity
D015415:Biomarkers; D007073:Immunoglobulin E; D002097:C-Reactive Protein; D007703:Peptidyl-Dipeptidase A