[Variation of mortality risk among cancer patients and individualized therapy].
To investigate the deviation of survival curves from monotonous shape, 17 curves for 6 most common cancer sites of 87,205 patients (aged 30-89) were selected from The U.S. Surveillance, Epidemiology and End Results (SEER) Register database. The curves were analyzed using monotonous exponential and harmonic functions which allowed a corresponding estimation of quasi-sinusoidal disturbances of monthly death hazard. Detectable fluctuations of the latter were established in the 0-40--month life span zone depending on tumor site and age at diagnosis.
A N
AN
Shutko
I
I
Akushevich
L P
LP
Ekimova
M A
MA
Karamullin
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008175:Lung Neoplasms / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality*; D057285:Precision Medicine; D011471:Prostatic Neoplasms / Q000401:mortality; D012004:Rectal Neoplasms / Q000401:mortality; D012306:Risk; D012426:Russia / Q000453:epidemiology; D018426:SEER Program; D013274:Stomach Neoplasms / Q000401:mortality; D013736:Testicular Neoplasms / Q000401:mortality; D014481:United States / Q000453:epidemiology