Pharmacology of ionotropic glutamate receptors: A structural perspective.
The impact of structural biology on the design of ligands (agonists, antagonists and modulators) for ionotropic glutamate receptors is reviewed.
Stawski
Philipp
P
Department of Chemistry, Ludwig-Maximilians-Universität, München Butenandtstr. 5-13 (F4.086), D-81377 Munich, Germany.
Janovjak
Harald
H
Trauner
Dirk
D
D006801:Humans; D008024:Ligands; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D018091:Receptors, AMPA / Q000819:agonists / Q000037:antagonists & inhibitors; D058468:Receptors, Ionotropic Glutamate / Q000819:agonists* / Q000037:antagonists & inhibitors*; D018092:Kainic Acid Receptors / Q000819:agonists / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000037:antagonists & inhibitors
D008024:Ligands; D018377:Neurotransmitter Agents; D018091:Receptors, AMPA; D058468:Receptors, Ionotropic Glutamate; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate