Perioperative protective effects of statins.
Although statins decrease cholesterol synthesis, they also possess 'pleiotropic' effects, such as enhancing the function of vascular endothelium and the stability of atherosclerotic plaques. Furthermore, they attenuate oxidative stress, inflammation, and the prothrombotic response. These diverse biological actions may explain their perioperative protective effects, especially in patients undergoing cardiac and major vascular procedures. Beyond reductions in perioperative mortality and cardiorenal complications, recent evidence also suggests outcome benefits from statin exposure in sepsis, airway hyperreactivity, and venous thromboembolism. It is likely that these agents will be increasingly prescribed perioperatively as high-quality evidence from well-designed randomized trials becomes available in the near future.
Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, University of Pennsylvania Philadelphia, PA 19104 USA.
Nina
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Singh
John G
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Augoustides