Bronchiolitis obliterans organizing pneumonia in Swine associated with porcine circovirus type 2 infection.
Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS), typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs), extracellular collagen matrix (ECM) deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (P < .05). Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.
Cheng
Ching-Chang
CC
Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Lee
Yen-Feng
YF
Lin
Nai-Nu
NN
Wu
Chieh-Liang
CL
Tung
Kwong-Chung
KC
Chiu
Yung-Tsung
YT
D000199:Actins / Q000378:metabolism; D056809:Alveolar Epithelial Cells / Q000378:metabolism; D000818:Animals; D002465:Cell Movement; D018173:Circoviridae Infections / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D017925:Circovirus; D018549:Cryptogenic Organizing Pneumonia / Q000209:etiology* / Q000473:pathology* / Q000662:veterinary; D004195:Disease Models, Animal; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000473:pathology / Q000821:virology; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D058628:Myofibroblasts / Q000201:enzymology / Q000473:pathology; D053495:Osteopontin / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000473:pathology / Q000821:virology*; D019282:Wasting Syndrome / Q000150:complications / Q000473:pathology / Q000662:veterinary*
D000199:Actins; D053495:Osteopontin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9