MicroRNAs and LPS: developing a relationship in the neonatal gut.
Upon birth, the intestine converts from a sterile environment to a home for commensal microorganisms. How immune homeostasis is maintained during this transition is not well understood. Here, Chassin et al. (2010) demonstrate that microRNA-146a regulates the responsiveness of intestinal epithelial cells during microbial colonization of the neonatal intestine.
Barbalat
Roman
R
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Barton
Gregory M
GM