Role of mitomycin C in reducing keloid recurrence: patient series and literature review.
OBJECTIVE
To study the role of mitomycin C in reducing keloid recurrence.


METHODS
Prospective, randomised, controlled trial.


METHODS
Tertiary care referral centre.


METHODS
Case series of 20 patients presenting with 26 pinna swellings, mostly following ear piercing.


METHODS
We used the technique of surgical shave excision combined with topical application of mitomycin C and secondary wound healing, in all 26 pinnae.


RESULTS
Patients were followed up six to 24 months post-operatively. No recurrences were noted during this period.


CONCLUSIONS
Keloids are fibrotic lesions resulting from abnormal wound healing. The uncontrolled proliferation of normal tissue healing processes results in scarring that enlarges well beyond the original wound margins. Successful treatment of keloids remains a challenge because this disease process has a high propensity for recurrence. Various therapies have previously been reported, and success rates are highly variable. We believe that shave excision followed by topical mitomycin C application is a promising treatment option for the management of pinna keloids.
Department of ENT, Gian Sagar Medical College and Hospital, Ram Nagar, Banur, Distt Patiala, Punjab, India. manishgupta1217@gmail.com
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Gupta
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Narang
D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D054644:Ear Auricle; D005260:Female; D006801:Humans; D007627:Keloid / Q000453:epidemiology / Q000601:surgery*; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011446:Prospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D055815:Young Adult
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin