Effect of IL-6 C-572G polymorphism on idiopathic membranous nephropathy risk in a Han Chinese population.
Membranous glomerulonephritis (MGN) is viewed as an immune-mediated glomerular disease, with immunologic expression occurring in genetically susceptible persons. The cytokine interleukin-6 (IL-6) gene polymorphism is known to impair intracellular signaling pathways following adaptive immune response. Our study gauged the effects of IL-6 C-572G (rs1800796) single nucleotide polymorphism (SNP) on MGN among Taiwan's Han Chinese population, as analyzed in 265 controls and 106 MGN patients. Genotyping for IL-6 C-572G SNP was performed by restriction fragment length polymorphism assay. Data showed stark differences in genotype and allele frequency distributions at IL-6 C-572G SNP between MGN patients and controls (p = 1.6E-04 and 1.7E-04, respectively). People with C allele or with CC genotype at IL-6 C-572G SNP showed higher risk of MGN (odds ratio = 2.42 and 2.71, respectively; 95% confidence interval = 1.51-3.87 and 1.60-4.60, respectively). These point to IL-6 C-572G polymorphism as the underlying cause of MGN; polymorphism merits further investigation.
Department of Medical Research, Genetic Center, China Medical University Hospital, Taichung, Taiwan, Republic of China. chenshihy@yahoo.com.tw
Shih-Yin
SY
Chen
Cheng-Hsu
CH
Chen
Yu-Chuen
YC
Huang
Hsuan-Min
HM
Chuang
Ming-Min
MM
Lo
Fuu-Jen
FJ
Tsai
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015433:Glomerulonephritis, Membranous / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D016036:Seroepidemiologic Studies; D013624:Taiwan / Q000453:epidemiology
D015850:Interleukin-6