An intramolecular PIFA-mediated metal-free allylic oxycarbonylation reaction and its application to the preparation of furopyrimidinones.
The preparation of a series of furo[3,4-d]pyrimidinones by an unprecedented PIFA-mediated intramolecular allylic oxycarbonylation reaction developed on 5-carbamoyl-substituted Biginelli adducts is presented. The construction of the fused lactone by a metal-free C-H activation process, without the need of an additional functionalization step, is featured in the present work.
Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco - Euskal Herriko Unibertsitatea, 48940 Leioa, Spain.
Irantzu
I
Couto
Imanol
I
Tellitu
Esther
E
Domínguez