Understanding the temporal codes of intra-cellular signals.
The health of organisms and cells depends on appropriate responses to diverse internal and external cues, stimuli, or challenges, such as changes in hormone or cytokine levels, or exposure to a pathogen. Cellular responses must be tailored to the identity and intensity of the stimulus and therefore intra-cellular signals must carry information about both. However, signaling mediators often form intricate networks that react to multiple stimuli yet manage to produce stimulus-specific responses. The multi-functionality ('functional pleiotropism') of signaling nodes suggests that biological networks have evolved ways of passing physiologically relevant stimulus information through shared channels. Increasing evidence supports the notion that this is achieved in part through temporal regulation of signaling mediators' activities. The present challenge is to identify the features of temporal activity profile that represent information about a given stimulus and understand how cells read the temporal codes to control their responses.
Signaling Systems Laboratory, BioCircuits Institute, and San Diego Center for Systems Biology of Cellular Stress Responses, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, United States.
Marcelo
M
Behar
Alexander
A
Hoffmann
D000818:Animals; D005786:Gene Expression Regulation; D042541:Intracellular Space; D015398:Signal Transduction