[Use of serum protein profiling for early diagnosis of gastric cancer].
OBJECTIVE
To identify serum biomarkers associated with early gastric cancer.


METHODS
Serum proteins or peptides were purified with weak cation exchange magnetic beads in 433 patients with gastric cancer and 120 healthy subjects. Distinct peaks were selected using Biomarker Wizard software. The area under receiver operating characteristic curve(AUC) was generated to analyze discrimination capability of peaks between gastric cancers and health people.


RESULTS
Thirteen distinct peaks were identified between 42 gastric cancer and 42 health people matched by age and gender(P<0.001). There were 5 peaks (2745, 2768, 6629, 3402, and 6436 m/z) with AUC greater than 0.8. Peak of 6629 m/z was identified to be transthyretin. The sensitivity and specificity of 6629 m/z were 65.5% and 92.0%. The sensitivity of 6629 m/z was 59.4% in I(A gastric cancer.


CONCLUSIONS
Transthyretin precursor may be of value in the early diagnosis of gastric cancer.
Zheng
Zhi-guo
ZG
Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Xu
Shen-hua
SH
Xu
Qi
Q
Zhu
Chi-hong
CH
Yu
Chuan-ding
CD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D040081:Protein Array Analysis; D040901:Proteomics / Q000379:methods*; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013274:Stomach Neoplasms / Q000097:blood*; D055815:Young Adult
D001798:Blood Proteins