Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats.
Disruption of maternal thyroid hormones during fetal developmental may result in irreversible neurological consequences in offspring. The present study tested the hypothesis that perinatal triclosan exposure of dams decreases thyroxine in dams and offspring prior to weaning. Pregnant Long-Evans rats received triclosan by oral gavage (0-300 mg/kg/d) in corn oil from gestational day (GD)6 through postnatal day (PND)21. Serum was obtained from pups on PND4, 14, and 21, and from dams on PND22. Serum thyroxine (T4) was reduced 31% in dams on PND22. In pups, a unique pattern of hypothyroxinemia was observed; serum T4 decreased 27% in PND4 pups with no significant reduction observed on PND14 or PND21. Comparable reductions of approximately 30% in serum T4 at 300 mg/kg/d for dams and PND4 neonates and a lack of effect at PND14 and PND21 suggest that toxicokinetic or toxicodynamic factors may have contributed to a reduced exposure or a reduced toxicological response during the lactation period.
Paul
Katie B
KB
University of North Carolina, Chapel Hill, North Carolina, USA.
Hedge
Joan M
JM
Devito
Michael J
MJ
Crofton
Kevin M
KM
D000818:Animals; D005260:Female; D006801:Humans; D023421:Models, Animal; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D020318:Rats, Long-Evans; D013974:Thyroxine / Q000097:blood*; D014260:Triclosan / Q000494:pharmacology*
D014260:Triclosan; D013974:Thyroxine