Tandem [4 + 1 + 1] annulation and metal-free aerobic oxidative aromatization: straightforward synthesis of highly substituted phenols from one aldehyde and two ketones.
Polysubstituted phenols are efficiently assembled from one aldehyde and two different methyl ketones in a one-pot operation via a newly base-induced regiospecific [4 + 1 + 1] annulation and sequential metal-free oxidative aromatization using molecular oxygen (from air) as the sole oxidant at room temperature.
Wang
Mang
M
Department of Chemistry, Northeast Normal University, Changchun 130024, China. wangm452@nenu.edu.cn
Fu
Zhenqian
Z
Feng
Hui
H
Dong
Ying
Y
Liu
Jun
J
Liu
Qun
Q
D000447:Aldehydes / Q000737:chemistry*; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D000447:Aldehydes; D007659:Ketones; D010636:Phenols; D010100:Oxygen