Insights into Cdc13 dependent telomere length regulation.
Cdc13 is a single stranded telomere binding protein that specifically localizes to the telomere ends of budding yeasts and is essential for cell viability. It caps the ends of chromosomes thus preventing chromosome end-to-end fusions and exonucleolytic degradation, events that could lead to genomic instability and senescence, the hallmark of aging. Cdc13 is also involved in telomere length regulation by recruiting or preventing access of telomerase to the telomeric overhang. Recruitment of telomerase to the telomeres for G-strand extension is required for continuous cell division, while preventing its access to the telomeres through capping the chromosome ends prevents mitotic events that could lead to cell immortality, the hall mark of carcinogenesis. Cdc13 and its putative homologues human CTC1 and POT1 are therefore key to many biological processes directly associated with life extension and cancer prevention and can be viewed as an ideal target for cancer and age related therapies.
The Wistar Institute, Philadelphia, PA 19103, USA.
Mark
M
Mason
Emmanuel
E
Skordalakes
D001665:Binding Sites; D002470:Cell Survival / Q000502:physiology; D004247:DNA / Q000378:metabolism; D004256:DNA Polymerase I / Q000378:metabolism; D019915:DNA Primase / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000502:physiology*; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000502:physiology*; D034501:Telomere-Binding Proteins / Q000737:chemistry / Q000502:physiology*
C452219:Cdc13 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D034501:Telomere-Binding Proteins; D004247:DNA; D019915:DNA Primase; C116932:DNA polymerase alpha-primase; D019098:Telomerase; D004256:DNA Polymerase I