Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.
Miller
Richard A
RA
Department of Pathology, University of Michigan, Ann Arbor, MI 48109-2200, USA. millerr@umich.edu
Harrison
David E
DE
Astle
C M
CM
Baur
Joseph A
JA
Boyd
Angela Rodriguez
AR
de Cabo
Rafael
R
Fernandez
Elizabeth
E
Flurkey
Kevin
K
Javors
Martin A
MA
Nelson
James F
JF
Orihuela
Carlos J
CJ
Pletcher
Scott
S
Sharp
Zelton Dave
ZD
Sinclair
David
D
Starnes
Joseph W
JW
Wilkinson
J Erby
JE
Nadon
Nancy L
NL
Strong
Randy
R
D000375:Aging / Q000187:drug effects / Q000235:genetics; D000818:Animals; D005260:Female; D018740:Genetic Heterogeneity; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D000077185:Resveratrol; D019821:Simvastatin / Q000008:administration & dosage*; D020123:Sirolimus / Q000008:administration & dosage*; D013267:Stilbenes / Q000008:administration & dosage*
D013267:Stilbenes; D019821:Simvastatin; D000077185:Resveratrol; D020123:Sirolimus