Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells.
Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.
Polyol Biotech Ltd, Granot Initiative Center, D.N. Hefer, Israel. gr.polyol@gmail.com
Gennady
G
Rosenblat
Shai
S
Meretski
Joseph
J
Segal
Mark
M
Tarshis
Avi
A
Schroeder
Alexandra
A
Zanin-Zhorov
Gilead
G
Lion
Arieh
A
Ingber
Malka
M
Hochberg
D000893:Anti-Inflammatory Agents; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair; D015232:Dinoprostone / Q000378:metabolism; D005233:Fatty Alcohols / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects* / Q000528:radiation effects; D009924:Organ Culture Techniques; D027421:Persea / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D011740:Pyrimidine Dimers / Q000032:analysis; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
D000893:Anti-Inflammatory Agents; D005233:Fatty Alcohols; D015850:Interleukin-6; D011740:Pyrimidine Dimers; D015232:Dinoprostone