Autophagy: a target for retinoic acids.
Autophagy is an intracellular catabolic process that responds with great sensitivity to nutrient availability, implying that certain macro- or micro-nutrients are involved. We found that retinoic acid promotes autophagosome maturation through a pathway independent from the classic nuclear retinoid receptors. Retinoic acid redistributes the cation-independent mannose-6-phosphate receptor from the trans-Golgi region to maturing autophagosomal structures inducing their acidification. Manipulation of the autophagic activity by retinoids could have enormous health implications, since they are essential dietary components and frequently used pharmaceuticals.
Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Yogendra
Y
Rajawat
Zoe
Z
Hilioti
Ioannis
I
Bossis
D001343:Autophagy / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D010588:Phagosomes / Q000187:drug effects / Q000378:metabolism; D017527:Receptor, IGF Type 2 / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D020123:Sirolimus / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology*; D021601:trans-Golgi Network / Q000187:drug effects / Q000378:metabolism
D017527:Receptor, IGF Type 2; D018168:Receptors, Retinoic Acid; D011993:Recombinant Fusion Proteins; D014212:Tretinoin; D020123:Sirolimus