Forming transmembrane channels using end-functionalized nanotubes.
Using dissipative particle dynamics (DPD) simulations, we examine the interaction between amphiphilic nanotubes and lipid bilayer membranes. The nanotubes are represented by a hydrophobic shaft that is end-functionalized with hydrophilic groups. Nanotubes that are capped by a monolayer of hydrophilic beads or also encompass hydrophilic "hairs" on just one end of the shaft are found to spontaneously penetrate and assume a transmembrane position; the process, however, depends critically on the membrane tension. On the other hand, nanotubes that include hydrophilic hairs at both ends of the hydrophobic shaft are not observed to spontaneously self-organize into the bilayer. When the membrane is stretched to form a pore, the nanotubes with two hairy ends adsorb on the edge of the pore and become localized in the membrane, thus forming a transmembrane channel. The findings from these studies provide guidelines for creating biomimetic nanotube channels that are capable of selectively transporting molecules through the membrane in response to changes in the local environment.
Chemical Engineering Department, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Meenakshi
M
Dutt
Olga
O
Kuksenok
Steven R
SR
Little
Anna C
AC
Balazs
D008051:Lipid Bilayers / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D043942:Nanotubes / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013500:Surface Tension
D008051:Lipid Bilayers; D012997:Solvents