Targeting of cancer cells using click-functionalized polymer capsules.
Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targeting offers promise for drug delivery applications.
Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.
Marloes M J
MM
Kamphuis
Angus P R
AP
Johnston
Georgina K
GK
Such
Henk H
HH
Dam
Richard A
RA
Evans
Andrew M
AM
Scott
Edouard C
EC
Nice
Joan K
JK
Heath
Frank
F
Caruso
D000906:Antibodies / Q000008:administration & dosage / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D045744:Cell Line, Tumor; D057930:Click Chemistry; D005434:Flow Cytometry; D006801:Humans; D008856:Microscopy, Fluorescence; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D011108:Polymers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*
D000906:Antibodies; D001386:Azides; D053769:Nanocapsules; D011108:Polymers