Mapping chromatin conformation.
Chromatin conformation capture (3C) and related techniques have become well-established methods to examine which distal DNA sequences are spatially located close to a locus of interest. Hi-C is a new addition to the growing set of 3C-based techniques that has extended the approach to a genome-wide analysis of nuclear chromatin using high-throughput DNA sequencing to generate global interaction maps for the entire genome.
Department of Cell and Developmental Biology, John Innes Centre Colney Lane, Colney, Norwich, NR4 7UH UK.
Peter J
PJ
Shaw