Treatment of through-and-through bone lesion using autologous growth factors and xenogeneic bone graft: a case report.
BACKGROUND
This pilot case study aimed at evaluating the possibility of achieving optimal hard and soft tissue regeneration using plasma rich in growth factors (PRGF) and anorganic bovine bone (ABB) for the surgical treatment of a large through-and-through periapical bone lesion.


METHODS
Maxillary incisors of a patient with through-and-through periapical lesion of endodontic origin were treated using modern endodontic surgical technique with the adjunct of PRGF. The PRGF clot was positioned over the palatal side of the lesion while the remaining bone defect was grafted with PRGF and ABB. A collagen membrane embedded with plasma very rich in growth factors covered the graft. Post-operative pain and swelling were negligible, and soft tissue healing was very fast. One-year clinical and radiographic outcome showed complete healing and functionality.


CONCLUSIONS
The addition of PRGF to ABB could improve the regenerative process, reducing postoperative symptoms and resulting in a fast and predictable hard and soft tissue healing.
Department of Health Technologies, IRCCS Istituto Ortopedico Galeazzi, University of Milan, Via R. Galeazzi 4, 20161 Milan, Italy.
Silvio
S
Taschieri
Gabriele
G
Rosano
Tommaso
T
Weinstein
Monica
M
Bortolin
Massimo
M
Del Fabbro
D000328:Adult; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007180:Incisor / Q000000981:diagnostic imaging / Q000601:surgery*; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000601:surgery*; D010482:Periapical Abscess / Q000000981:diagnostic imaging / Q000601:surgery*; D010486:Periapical Tissue / Q000000981:diagnostic imaging / Q000601:surgery*; D011862:Radiography, Panoramic; D019553:Tooth, Nonvital; D014183:Transplantation, Heterologous
D018786:Bone Substitutes; D036341:Intercellular Signaling Peptides and Proteins