Verification of intramolecular hybrid/parallel g-quadruplex structure under physiological conditions using novel cyanine dye H-aggregates: both in solution and on Au film.
The H-aggregates of a novel cyanine dye, 3,3'-di(3-sulfopropyl)-4,5,4',5'-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MTC), have been fabricated to verify hybrid/parallel intramolecular G-quadruplexes from linear duplex and single-strand DNAs under physiological conditions. The recognition is found to be successful both in solution and on Au film. These results have shown MTC H-aggregates, as a supramolecular system, may be used as a potential excellent probe for DNA structure, both in vitro and in vivo.
Qianfan
Q
Yang
Jun-Feng
JF
Xiang
Shu
S
Yang
Qian
Q
Li
Qiuju
Q
Zhou
Aijiao
A
Guan
Lin
L
Li
Yanxia
Y
Zhang
Xiufeng
X
Zhang
Hong
H
Zhang
Yalin
Y
Tang
Guangzhi
G
Xu