Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.
Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases.
Wei
Bin
B
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Jin
J-P
JP
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D013045:Species Specificity; D020107:Troponin T / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D020033:Protein Isoforms; D020107:Troponin T