Highly efficient and directional homo- and heterodimeric energy transfer materials based on fluorescently derivatized α,γ-cyclic octapeptides.
Cyclic octapeptides composed of α-amino acids alternated with cis-3-aminocycloalkanecarboxylic acids, self-assemble as drumlike dimers through β-sheet-like, backbone-to-backbone hydrogen bonding. Heterodimerization appears to be significantly more favored than homodimerization, and this represents a novel approach for the design and fabrication of highly stable heterodimeric assemblies. A multicomponent equilibrium network based on fluorescently derivatized self-assembling α,γ-cyclic octapeptides has been successfully used to form light-harvesting/light-converting ensembles with a distinctive organization of donor and acceptor units able to act as efficient artificial photosystems.
Departamento de Química Orgánica y Unidad Asociada al C.S.I.C. Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Campus Vida, Universidad de Santiago, 15782 Santiago de Compostela, Spain.
Roberto J
RJ
Brea
María Jesús
MJ
Pérez-Alvite
Michele
M
Panciera
Manuel
M
Mosquera
Luis
L
Castedo
Juan R
JR
Granja
D019281:Dimerization; D004735:Energy Transfer; D005453:Fluorescence; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry*
D010456:Peptides, Cyclic