Reconstruction of biological networks based on life science data integration.
For the implementation of the virtual cell, the fundamental question is how to model and simulate complex biological networks. Therefore, based on relevant molecular database and information systems, biological data integration is an essential step in constructing biological networks. In this paper, we will motivate the applications BioDWH--an integration toolkit for building life science data warehouses, CardioVINEdb--a information system for biological data in cardiovascular-disease and VANESA--a network editor for modeling and simulation of biological networks. Based on this integration process, the system supports the generation of biological network models. A case study of a cardiovascular-disease related gene-regulated biological network is also presented.
Kormeier
Benjamin
B
Bioinformatics Department, Bielefeld University, PO Box 100131, 33501 Bielefeld, Germany.
Hippe
Klaus
K
Arrigo
Patrizio
P
Töpel
Thoralf
T
Janowski
Sebastian
S
Hofestädt
Ralf
R
D001690:Biological Science Disciplines / Q000379:methods*; D002318:Cardiovascular Diseases / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D008957:Models, Genetic; D015398:Signal Transduction / Q000235:genetics; D012984:Software; D019108:Tight Junctions / Q000378:metabolism