Association of vitamin D receptor Taq I polymorphism and susceptibility to oral squamous cell carcinoma.
BACKGROUND
It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis.


METHODS
The distribution of VDR Taq I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RFLP) and compared with that of 87 healthy controls.


RESULTS
There was a significant difference in the distribution of VDR Taq I genotypes between OSCC patients and healthy controls. Patients with the VDR Tt genotype were found to be at significantly higher risk for OSCC than those with other genotypes (p=0.036). In particular, female OSCC patients were at higher risk (p<0.001) for oral cancer.


CONCLUSIONS
These results suggest that the VDR Taq I polymorphism may be associated with susceptibility to OSCC. Female predilection of the OSCC risk in association with VDR gene polymorphism should also be investigated.
İstanbul Üniversitesi Dişhekimliği Fakültesi, Ağız,Diş, Çene Hastalıkları Bilim Dalı 6.kat, 34093 Çapa/İstanbul, Turkey. bektaskk@istanbul.edu.tr
Kivanç
K
Bektas-Kayhan
Meral
M
Unür
Ilhan
I
Yaylim-Eraltan
H Arzu
HA
Ergen
Bahar
B
Toptas
Günter
G
Hafiz
Ahmet
A
Karadeniz
Turgay
T
Isbir
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
D018167:Receptors, Calcitriol