24-hour temporal pattern of NTPDase and 5'-nucleotidase enzymes in rat blood serum.
Circadian rhythms represent an important mechanism to prepare the organism for environmental variations. ATP, ADP, AMP, and adenosine can act as extracellular messengers in a range of biological processes and are metabolized by a number of enzymes, including NTPDases and 5'-nucleotidase. In the present study the authors report that ATPase and ADPase activities present 24-h temporal variations that peak during dark (activity) span. These findings suggest that this enzymatic temporal pattern in blood serum might be important for the normal physiology and function of the organism through the maintenance of extracellular nucleotides at physiological levels.
Detanico
Bernardo Carraro
BC
Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Porto Alegre, Brazil.
de Souza
Andressa
A
Medeiros
Liciane Fernandes
LF
Rozisky
Joanna Ripoll
JR
Caumo
Wolnei
W
Hidalgo
Maria Paz Loayza
MP
Battastini
Ana Maria Oliveira
AM
Torres
Iraci Lucena da Silva
IL
D015720:5'-Nucleotidase / Q000097:blood*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000097:blood; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001081:Apyrase / Q000097:blood; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood; D007700:Kinetics; D008297:Male; D008550:Melatonin / Q000097:blood; D009708:Nucleotidases / Q000097:blood; D051381:Rats; D017208:Rats, Wistar
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D009708:Nucleotidases; C018775:adenosine monophosphatase; D015720:5'-Nucleotidase; D000251:Adenosine Triphosphatases; D001081:Apyrase; D008550:Melatonin; D003345:Corticosterone