Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.
Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the formation of the products. The antimycobacterial activity of the isomeric compounds has been tested against Mycobacterium tuberculosis (MTB).
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
Ramaiyan
R
Manikannan
Ramaiyan
R
Venkatesan
Shanmugam
S
Muthusubramanian
Perumal
P
Yogeeswari
Dharmarajan
D
Sriram
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D004126:Dimethylformamide; D005559:Formamides / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D005559:Formamides; D011720:Pyrazoles; D013440:Sulfides; D004126:Dimethylformamide