Gremlin: an interactive visualization model for analyzing genomic rearrangements.
In this work we present, apply, and evaluate a novel, interactive visualization model for comparative analysis of structural variants and rearrangements in human and cancer genomes, with emphasis on data integration and uncertainty visualization. To support both global trend analysis and local feature detection, this model enables explorations continuously scaled from the high-level, complete genome perspective, down to the low-level, structural rearrangement view, while preserving global context at all times. We have implemented these techniques in Gremlin, a genomic rearrangement explorer with multi-scale, linked interactions, which we apply to four human cancer genome data sets for evaluation. Using an insight-based evaluation methodology, we compare Gremlin to Circos, the state-of-the-art in genomic rearrangement visualization, through a small user study with computational biologists working in rearrangement analysis. Results from user study evaluations demonstrate that this visualization model enables more total insights, more insights per minute, and more complex insights than the current state-of-the-art for visual analysis and exploration of genome rearrangements.
O'Brien
Trevor M
TM
Computer Science Department, Brown University, Providence, RI 02912, USA. trevor@cs.brown.edu
Ritz
Anna M
AM
Raphael
Benjamin J
BJ
Laidlaw
David H
DH
D003196:Computer Graphics; D003198:Computer Simulation; D030541:Databases, Genetic; D015321:Gene Rearrangement; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D014584:User-Computer Interface