[A case of mucosa-associated lymphoid tissue lymphoma with penicillin allergy successfully treated with levofloxacin, minomycin and rabeprazole].
A 52-year-old Japanese woman was referred to our Institute because of Helicobacter pylori(H. pylori)-positive gastric mucosa-associated lymphoid tissue(MALT)lymphoma. Since she had a penicillin allergy, we could not eradicate H. pylori using the standard triple therapy including amoxicillin. Additionally, H. pylori was resistant to both clarithromycin and metronidazole. So she was treated with minomycin (MINO), levofloxacin (LVFX), and rabeprazole (RPZ) based on a drug sensitivity test. MINO+LVFX+RPZ appear to be a promising, appropriate, and well-tolerated eradication regimen for H. pylori demonstrating resistance to both clarithromycin and metronidazole, and for patients who are allergic to penicillin.
Konno
Tomoko
T
Department of Laboratory Medicine, Kaken Hospital, Chemotherapy Research Institute, and Department of Internal Medicine, Medical Oncology, Kyorin University School of Medicine.
Motoori
Shigeatsu
S
Iwamoto
Nozomi
N
Miyazawa
Tomoe
T
Saito
Shigeyo
S
Kitagawa
Naoko
N
Saisho
Hiromitsu
H
Furuse
Junji
J
Itabashi
Masayuki
M
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D064704:Levofloxacin; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D010406:Penicillins / Q000276:immunology*; D064750:Rabeprazole
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D010406:Penicillins; D064750:Rabeprazole; D064704:Levofloxacin; D015242:Ofloxacin; D008911:Minocycline