Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis.
The efficiency of a chemical synthesis can be nowadays measured, not only by parameters like selectivity and overall yield, but also by its raw material, time, human resources and energy requirements, as well as the toxicity and hazard of the chemicals and the protocols involved. The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. The aim of this tutorial review is to highlight the synergistic effect of the combined use of MCRs and ILs for the development of new eco-compatible methodologies for heterocyclic chemistry.
Isambert
Nicolas
N
Aix-Marseille Université-Institut des Sciences Moléculaires de Marseille-UMR CNRS 6263 iSm2, Centre Saint Jérôme, Service 531, 13397, Marseille Cedex 20, France.
Sanchez Duque
Maria del Mar
Mdel M
Plaquevent
Jean-Christophe
JC
Génisson
Yves
Y
Rodriguez
Jean
J
Constantieux
Thierry
T