Immunologic changes in obesity.
A growing body of literature suggests multifaceted alterations to the immune function in obese patients compared with a lean cohort. Although treatment in the intensive care unit has an associated risk of infectious complications, which, if any, of these immunologic alterations are causal is unclear. Obesity clearly causes abundant alterations to the immune system. Overall, the aggregate effect seems to be chronic activation of inflammatory mediators.
Division of Critical Care Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, USA.
Mitchell K
MK
Craft
Mary Jane
MJ
Reed
D054392:Adipokines / Q000276:immunology; D052436:Adipose Tissue, White / Q000276:immunology*; D006801:Humans; D055633:Immune System Phenomena / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D009765:Obesity / Q000276:immunology*
D054392:Adipokines