Benefit of gluten-free diet in idiopathic pulmonary hemosiderosis in association with celiac disease.
Lane-Hamilton syndrome refers to the uncommon co-occurrence of idiopathic pulmonary hemosiderosis and celiac disease (CD). Three children aged between 7 and 14 years with IPH were detected to have co-existing non-diarrheal CD. Institution of gluten-free diet in each of the three children resulted in amelioration of the pulmonary symptoms along with improvement of anthropometric parameters and hemoglobin over a short-term follow-up period of 8-17 months. Inhaled/oral steroids and immunosuppressants could be weaned off after dietary exclusion therapy in each of the three children. Gluten free diet should be instituted in all patients diagnosed with Lane-Hamilton syndrome. It ameliorates both the pulmonary as well as the intestinal symptoms although the precise mechanism of the pulmonary response is as yet unclear.
Sethi
Gulshan R
GR
Department of Pediatrics, Lok Nayak Hospital, New Delhi, India.
Singhal
Kamal K
KK
Puri
Amarender S
AS
Mantan
Mukta
M
D000293:Adolescent; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy*; D002648:Child; D055050:Diet, Gluten-Free; D005260:Female; D006486:Hemosiderosis / Q000150:complications* / Q000178:diet therapy*; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000178:diet therapy*; D008297:Male; D000097545:Hemosiderosis, Pulmonary