Development and performance analysis of PCL/silica nanocomposites for bone regeneration.
In the present article, several developments of biocomposites containing silica nanoparticles intended for bone regeneration are reported. Nanocomposites of poly(ε-caprolactone) (PCL) and silica, in which either the silica nanoparticles or the PCL have been modified in order to improve interfacial adhesion through chemical graft between the phases are hereafter described. The composites are characterized with respect to their chemical-physical and mechanical properties. Their biocompatibility and capacity to induce the osteoblastic phenotype in human bone marrow mesenchymal stem cells have been assessed.
Institute of Polymers Chemistry and Technology, CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy. luigi.calandrelli@ictp.cnr.it
Luigi
L
Calandrelli
Marco
M
Annunziata
Fulvio
F
Della Ragione
Paola
P
Laurienzo
Mario
M
Malinconico
Adriana
A
Oliva
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D008422:Materials Testing / Q000379:methods; D051379:Mice; D008954:Models, Biological; D041681:NIH 3T3 Cells; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D012822:Silicon Dioxide