Copper-catalyzed synthesis of quinazoline derivatives via Ullmann-type coupling and aerobic oxidation.
A simple and efficient copper-catalyzed approach to quinazoline derivatives has been developed, and the protocol uses readily available substituted (2-bromophenyl)methylamines and amides as the starting materials, and the cascade reactions were performed under air via sequential Ullmann-type coupling and aerobic oxidation without addition of any ligand or additive. The present method provides a convenient and practical strategy for synthesis of quinazoline derivatives.
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
Chen
C
Wang
Shangfu
S
Li
Hongxia
H
Liu
Yuyang
Y
Jiang
Hua
H
Fu
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D008744:Methylamines / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
D008024:Ligands; D008744:Methylamines; D011799:Quinazolines; D003300:Copper