Enantioselective synthesis of anti-β-hydroxy-α-amido esters via transfer hydrogenation.
The asymmetric transfer hydrogenation of α-amido-β-keto esters to provide the corresponding anti-β-hydroxy-α-amido esters in good to excellent yields, diastereoselectivity, and enantioselectivity is reported. The procedure is operationally simple, and delicate handling of the catalyst is not necessary.
Seashore-Ludlow
Brinton
B
Organic Chemistry, KTH Chemical Science and Engineering, Royal Institute of Technology, 100 44 Stockholm, Sweden.
Villo
Piret
P
Häcker
Christine
C
Somfai
Peter
P
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism
D000577:Amides; D004952:Esters