Identification and characterization of two new HIV type 1 Unique (B/C) recombinant forms in China.
Recombination was most important in the generation of new viral strains and in the increase of HIV diversity. There were more and more new HIV-1 strains. Not only circulating recombinant forms (CRFs) but also unique recombinant forms (URFs) have been reported around the world. CRF07_BC and CRF08_BC were the two predominant CRFs circulated in Yunnan Province, southwest China. In the present study, we identified two new HIV Type 1 unique (B/C) recombinant gorms in Yunnan Province by nucleotide sequencing in two halves of HIV genome. Although the genomic structures of the two B/C recombinants were different from previously identified CRFs (CRF07_BC and CRF08_BC) and URFs in Yunnan Pprovince, they have several common recombination sites with CRF07_BC and CRF08_BC.
Department of HIV/AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yongjian
Y
Liu
Lin
L
Li
Shaomin
S
Yang
Zuoyi
Z
Bao
Hanping
H
Li
Zheng
Z
Wang
Daomin
D
Zhuang
Siyang
S
Liu
Lili
L
Chen
Yishan
Y
Fan
Min
M
Zhong
Li
L
Gao
Xiaolin
X
Wang
Jingyun
J
Li
D000328:Adult; D002681:China; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
D012367:RNA, Viral