The role of the blood transcriptome in innate inflammation and stroke.
Cerebrovascular disease is a major cause of death and disability, with a poorer outcome in patients having select risk factors including diabetes and hypertension. Risk factors and the state of cerebral ischemia-reperfusion associated with cerebrovascular occlusion are known to cause inflammatory changes. These events and the inflammatory state are reflected by transcript changes in various components of the blood and can be specifically measured. By defining these changes, new insight into cerebrovascular disease and its therapeutics is being achieved.
Freedman
Jane E
JE
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. freedmaj@bu.edu
Vitseva
Olga
O
Tanriverdi
Kahraman
K
D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007249:Inflammation / Q000097:blood* / Q000235:genetics* / Q000276:immunology; D008959:Models, Neurological; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000235:genetics* / Q000276:immunology