Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis.
This pilot study evaluated protection of an equine autogenous bacterin-toxoid vaccine against Corynebacterium pseudotuberculosis infection. Twenty-four BALB/c mice were inoculated with two doses of bacterin-toxoid vaccine or two injections of a placebo. Clinical, microbiologic, and pathologic outcomes were assessed after intradermal infection with one of two equine-origin C. pseudotuberculosis strains. Mice receiving bacterin-toxoid from fast-growing C. pseudotuberculosis showed significant protection from challenge infection, as evidenced by a higher survival rate, fewer gross and histopathologic lesions, and lower bacterial levels on culture. Successful protection via a vaccine against equine internal abscesses might provide supplementary management options against an important, potentially fatal disease.
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, One Shields Ave., Davis, CA 95616, USA.
Jennifer K
JK
Gorman
Mourad
M
Gabriel
N James
NJ
MacLachlan
Nathan
N
Nieto
Janet
J
Foley
Sharon
S
Spier
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D003354:Corynebacterium Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D016925:Corynebacterium pseudotuberculosis / Q000276:immunology*; D006734:Horse Diseases / Q000382:microbiology / Q000517:prevention & control*; D006736:Horses; D051379:Mice; D008807:Mice, Inbred BALB C; D010865:Pilot Projects
D001428:Bacterial Vaccines