Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.
By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13-26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum.
Jensen
Jens H
JH
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016-3295, USA. jj33@nyu.edu
Falangola
Maria F
MF
Hu
Caixia
C
Tabesh
Ali
A
Rapalino
Otto
O
Lo
Calvin
C
Helpern
Joseph A
JA
D000368:Aged; D001921:Brain / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged