Triterpenoidal saponins: bioactive secondary metabolites from Zygophyllum coccineum.
Phytochemical investigation of the aerial parts of Zygophyllum coccineum L. led to the isolation of nine ursane-type triterpene saponins (1- 9), including the new one; zygophylloside S (1), together with a known flavonoid glycoside (10) and a sterol glycoside (11). The isolated compounds were tested for antifungal activity against several important plant pathogens and for insecticidal activity against two important mosquito species. Among the isolated compounds 1, 3, 5, 6, and 9 showed 32-77 % fungal growth inhibition at a concentration of 30 µM against Phomopsis viticola. Compound 9 showed 90 % and 80 % mosquitocidal activity at 3.1 µg/0.5 µL against Aedes aegypti and Culex quinquefasciatus, respectively.
Amin
Elham
E
Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt.
El-Hawary
Seham S
SS
Fathy
Magda M
MM
Mohammed
Rabab
R
Ali
Zulfiqar
Z
Tabanca
Nurhayat
N
Wedge
David E
DE
Becnel
James J
JJ
Khan
Ikhlas A
IA
D000330:Aedes / Q000187:drug effects; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D003465:Culex / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032445:Zygophyllum / Q000737:chemistry*
D000935:Antifungal Agents; D007306:Insecticides; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes