Large fetal goiter due to placental passage of maternal antithyroperoxidase antibodies.
We report a case of fetal goiter in a pregnant woman with Graves-Basedow disease. It was diagnosed in the third trimester by a routine ultrasound, and the cordocentesis verified increased levels of thyroxine (T4) and increased autoantibodies (antithyroperoxidase antibodies) that were also increased in maternal blood. Fetal goiter got smaller on the follow-up scans, and the newborn presented hypothyroidism. Current notions on the diagnosis and management of fetal goiter are briefly discussed.
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada, Spain.
Irene
I
Vico
Francisca S
FS
Molina
Pedro
P
Alarcón-Blanco
Santiago
S
Durán
Guillermo
G
Azumendi
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000276:immunology*; D006042:Goiter / Q000000981:diagnostic imaging / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D021041:Placental Circulation; D011247:Pregnancy; D014463:Ultrasonography
D001323:Autoantibodies