How long does it take to establish a morphogen gradient?
A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.
Alexander M
AM
Berezhkovskii
Christine
C
Sample
Stanislav Y
SY
Shvartsman
D002454:Cell Differentiation / Q000187:drug effects*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism* / Q000494:pharmacology*; D007700:Kinetics; D008954:Models, Biological
D036341:Intercellular Signaling Peptides and Proteins