[A case of curatively resected locally advanced pancreatic cancer after chemoradiation therapy].
A 68-year-old man admitted for pancreatic tumor detected by US was found by computed tomography(CT)to have locally advanced pancreatic cancer invading the portal vein and neural plexus of the superior mesenteric artery without distant metastasis. We conducted preoperative chemoradiation therapy containing S-1 and hyperfractionated accelerated radiation therapy (50 Gy). Reevaluation of CT after chemoradiation therapy showed that the primary tumor reduced 52% without distant metastasis. Based on these findings, we conducted subtotal stomach-preserving pancreaticoduodenectomy with portal vein resection. Pathological examination revealed moderately-differentiated adenocarcinoma. Extensive fibrosis with a small amount of cancer cells was observed in the marginal area of the tumor. The portal vein was surrounded with extensive fibrosis and free from cancer cells. Extrapancreatic nerve plexus invasion and lymph node metastasis were not observed. There were no residual cancer cells (R0). The postoperative course was uneventful, and adjuvant chemotherapy (S-1) was started. The patient remains well without recurrence 12 months after surgery.
Department of Surgical Oncology and Digestive Surgery, Graduate School of Medical Science, Kagoshima University.
Hiroshi
H
Kurahara
Hiroyuki
H
Shinchi
Kousei
K
Maemura
Yuko
Y
Mataki
Masaya
M
Aoki
Masahiko
M
Sakoda
Shinichi
S
Ueno
Shoji
S
Natsugoe
Sonshin
S
Takao
D000368:Aged; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid