[Syndrome of accelerated aging induced by carcinogenic environmental factors].
The available data on effect of various environmental carcinogenic factors (chemical mutagens, polycyclic aromatic hydrocarbons, nitroso compounds, aromatic amines, tobacco smoking, ionizing radiation, constant illumination, alimentary obesity) upon the organisms suggest that it induces standard pattern of changes at different levels of integration (molecular, cellular, systemic) similar to characteristics of accelerated aging. These changes are favorable to development of age-associated diseases, including cardiovascular those, malignancies, diabetes mellitus type 2, metabolic syndrome, decrease in resistance to stress, immunodepression which lead to life span reduction and premature death.
V N
VN
Anisimov
D000375:Aging / Q000235:genetics* / Q000473:pathology; D002274:Carcinogens, Environmental / Q000633:toxicity*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology; D009153:Mutagens / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000503:physiopathology; D009603:Nitroso Compounds / Q000633:toxicity; D009765:Obesity / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D011839:Radiation, Ionizing; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014898:Werner Syndrome / Q000139:chemically induced* / Q000235:genetics / Q000503:physiopathology
D002274:Carcinogens, Environmental; D009153:Mutagens; D009603:Nitroso Compounds; D011084:Polycyclic Aromatic Hydrocarbons