A case-control study: occupational cooking and the risk of uveal melanoma.
BACKGROUND
A European-wide population based case-control study (European rare cancer study) undertaken in nine European countries examined risk factors for uveal melanoma. They found a positive association between cooks and the risk of uveal melanoma. In our study we examine whether cooks or people who worked in cook related jobs have an increased uveal melanoma risk.


METHODS
We conducted a case-control study during 2002 and 2005. Overall, 1653 eligible subjects (age range: 20-74 years, living in Germany) participated. Interviews were conducted with 459 incident uveal melanoma cases, 827 population controls, 180 ophthalmologist controls and 187 sibling controls. Data on occupational exposure were obtained from a self-administered postal questionnaire and a computer-assisted telephone interview. We used conditional logistic regression to estimate odds ratios adjusting for the matching factors.


RESULTS
Overall, we did not observe an increased risk of uveal melanoma among people who worked as cooks or who worked in cook related jobs. When we restricted the source population of our study to the population of the Federal State of Northrhine-Westphalia, we observed an increased risk among subjects who were categorized as cooks in the cases-control analysis.


CONCLUSIONS
Our results are in conflict with former results of the European rare cancer study. Considering the rarity of the disease laboratory in vitro studies of human uveal melanoma cell lines should be done to analyze potential exposure risk factors like radiation from microwaves, strong light from incandescent ovens, or infrared radiation.
Institute of Clinical Epidemiology, Medical Faculty, University of Halle-Wittenberg, Halle, Germany. andrea.schmidt-pokrzywniak@medizin.uni-halle.de
Andrea
A
Schmidt-Pokrzywniak
Karl-Heinz
KH
Jöckel
Anja
A
Marr
Norbert
N
Bornfeld
Andreas
A
Stang
D000328:Adult; D000368:Aged; D016001:Confidence Intervals; D003296:Cooking; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007259:Infrared Rays / Q000009:adverse effects; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014604:Uveal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult; D000098943:Uveal Melanoma