Preclinical and clinical activity of ATP mimetic JAK2 inhibitors.
The discovery of a common Janus kinase 2 (JAK2) point mutation, JAK2V617F, in myeloproliferative neoplasms has generated enormous interest in the development and therapeutic use of small molecule JAK2 inhibitor-targeted therapy in these diseases. A handful of compounds are currently in clinical development in primary myelofibrosis or post-polycythemia vera (PV)/essential thrombocythemia (ET) myelofibrosis. To date, clinical benefit has been demonstrated in terms of reduction of splenomegaly, improvement in constitutional symptoms, and control of leukocytosis. Some of the drugs have also been evaluated in PV and ET, with demonstrated activity against erythrocytosis, thrombocytosis, pruritus, and splenomegaly. However, drug effect on bone marrow fibrosis or JAK2 allele burden has been modest so far. Regardless, it is important to keep in mind that current anti-JAK2 treatment trials constitute only the beginning of many upcoming similar clinical trials, and that it is premature to make generalizations or any form of comparative conclusions regarding drug activity or toxicity.
Wadleigh
Martha
M
Leukemia Program, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Martha_wadleigh@dfci.harvard.edu
Tefferi
Ayalew
A
D000255:Adenosine Triphosphate; D000818:Animals; D002986:Clinical Trials as Topic; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors* / Q000235:genetics; D009196:Myeloproliferative Disorders / Q000188:drug therapy*; D017354:Point Mutation
D004791:Enzyme Inhibitors; D000255:Adenosine Triphosphate; D053614:Janus Kinase 2