Deciphering proteins and their functions in the regenerating retina.
Neurons of the mammalian CNS, including retinal ganglion cells, lack, in contrast to the PNS, the ability to regenerate axons spontaneously after injury. Regeneration of the CNS is extremely complex and involves various molecular factors and cells. Therewith the regenerative process remains an enormous scientific and clinical challenge. This article provides an overview of proteins that play a crucial role in axon regeneration of retinal ganglion cells and their underlying signaling pathways. In this context, we elucidate the role of 2D gel electrophoresis and highlight some additional proteins, altered upon regeneration by using this highly sensitive method.
Prokosch
Verena
V
Department of Experimental Ophthalmology, School of Medicine, University Eye Hospital Muenster, D-48149 Muenster, Germany.
Chiwitt
Carolin
C
Rose
Karin
K
Thanos
Solon
S
D000818:Animals; D001369:Axons / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D012165:Retinal Ganglion Cells / Q000502:physiology*
D011506:Proteins