Endogenous gastric mediators: patho-physiological role and measurements.
The protocols described in this unit are designed to present the major endogenous gastric mediators involved in the control of gastric acid secretion, namely gastrin and histamine, and in the regulation of gastric motility, which include motilin and ghrelin, under physiological and pathological conditions. The measurement of these mediators in plasma or serum of humans and animals by radioimmunoassay are described and their pathophysiological role is discussed.
Jagiellonian University, Cracow, Poland.
Stanislaw J
SJ
Konturek
Wladysław
W
Bielanski
Peter C
PC
Konturek
Thomas
T
Brzozowski
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000503:physiopathology*; D005755:Gastrins / Q000097:blood* / Q000502:physiology*; D054439:Ghrelin / Q000097:blood; D006632:Histamine / Q000097:blood* / Q000502:physiology*; D006801:Humans; D009037:Motilin / Q000097:blood; D011863:Radioimmunoassay / Q000379:methods; D014116:Toxicology / Q000379:methods
D005755:Gastrins; D054439:Ghrelin; D009037:Motilin; D006632:Histamine