Aquaporin 1, a potential therapeutic target for migraine with aura.
The pathophysiology of migraine remains largely unknown. However, evidence regarding the molecules participating in the pathophysiology of migraine has been accumulating. Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases. This review outlines newly emerging evidence indicating that AQP-1 plays an important role in pain signal transduction and migraine and could therefore serve as a potential therapeutic target for these diseases.
Xu
Guang-Yin
GY
Key Laboratory of Pain Research & Therapy, Department of Neurobiology and Institute of Neuroscience, Soochow University, Suzhou, P.R. China.
Wang
Fen
F
Jiang
Xinghong
X
Tao
Jin
J
D000818:Animals; D051398:Aquaporin 1 / Q000737:chemistry / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology; D004827:Epilepsy / Q000150:complications* / Q000628:therapy*; D006801:Humans; D008881:Migraine Disorders / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D008954:Models, Biological; D009619:Nociceptors / Q000378:metabolism
D051398:Aquaporin 1