Parametric uncertainties and influence of the dead volume representation in modelling simulated moving bed separation processes.
In this study, a systematic numerical procedure for identifying the model parameters of simulated moving bed (SMB) separation processes is developed. The parameters are first estimated by minimizing a weighted least-squares criterion using experimental data from batch experiments, e.g. the time evolution of the concentration of elution peaks. Then, a cross-validation is achieved using data from experiments in SMB operation. At this stage, the importance of a careful modelling of the dead volumes within the SMB process is highlighted. In addition, confidence intervals on the estimated parameters and on the predicted concentration profiles are evaluated.
Grosfils
V
V
Service d'Automatique et d'Analyse des Systèmes, Université Libre de Bruxelles, CP 165/55, 50, Av. F. D. Roosevelt, B-1050 Brussels, Belgium.
Hanus
R
R
Wouwer
A Vande
AV
Kinnaert
M
M
D002845:Chromatography / Q000295:instrumentation*; D008962:Models, Theoretical; D012117:Resins, Synthetic / Q000737:chemistry
D012117:Resins, Synthetic