Effects of a mineral antioxidant complex on clinical safety, body water, lactate response, and aerobic performance in response to exhaustive exercise.
BACKGROUND
This investigation examined the safety and efficacy of a silica-based mineral antioxidant complex (MAC) that has been suggested to influence body water and buffer lactate.


METHODS
In a double-blind, randomized crossover design, male participants completed testing for 3 conditions: water only (baseline), rice flour (placebo), and MAC supplementation. Participants visited the laboratory on 5 occasions: familiarization, baseline, Testing Day 1, washout, and Testing Day 2. Baseline and Testing Days 1 and 2 consisted of fasting blood, pre- to postexercise body-water assessment and determination of VO2peak on a cycle ergometer. The supplementation protocols were separated by 1 wk and balanced to minimize an order effect.


RESULTS
No differences between conditions were found for heart rate, blood pressure, or serum-safety markers (p>.05). Before exercise there were no differences between conditions for total body water (TBW), intracellular water (ICW), or extracellular water (ECW). No significant interactive effects for supplementation and exercise were found for TBW, ICW, or ECW (p>.05). A time effect for TBW (p<.01) and ICW (p<.001) was present. Within-group changes in TBW occurred in the MAC condition, and within-group changes for ICW occurred in the MAC and placebo conditions. Ratings of perceived exertion and blood lactate increased (p<.05) with exercise. No significant effects were found for performance variables.


CONCLUSIONS
MAC supplementation had no impact on aerobic exercise performance and lactate response. Increases in TBW and ICW occurred after MAC consumption, but these changes appeared to have minimal physiological impact.
School of Medicine and Applied Sciences, Central Queensland University, Rockhampton, Australia.
Vincent J
VJ
Dalbo
Michael D
MD
Roberts
Scott E
SE
Hassell
Jordan R
JR
Moon
Chad M
CM
Kerksick
D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001642:Bicycling / Q000502:physiology; D001834:Body Water / Q000378:metabolism*; D003257:Consumer Product Safety; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D017097:Electric Impedance; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male; D008903:Minerals / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D055815:Young Adult
D000975:Antioxidants; D007773:Lactates; D008903:Minerals; D012822:Silicon Dioxide