Platelet-large cell ratio and the extent of coronary artery disease: results from a large prospective study.
Even though platelet volume has been supposed to be indicator of platelet activation, contrasting results have been reported on its relationship with the extent of coronary artery disease (CAD). No data have been so far reported on Platelet-Large Cell Ratio (P-LCR). Thus, the aim of the current study was to investigate whether P-LCR is associated with CAD. We measured P-LCR in 1882 consecutive patients undergoing coronary angiography. Significant CAD was defined as stenosis >50% in at least 1 coronary vessel. We additionally measured Carotid Intima-Media Thickness (IMT) in 359 patients. The relationship between P-LCR and platelet aggregation was evaluated by PFA-100 and Multiplate. Patients with higher P-LCR were older (P = 0.038), with larger prevalence of diabetes (P < 0.0001), dilated cardiomyopathy or valvular heart disease (P = 0.004) and less often family history of CAD (P = 0.045), more often on statins (P = 0.002), and diuretics (P = 0.016). P-LCR was significantly associated with baseline glycaemia (P = 0.001) and RBC count (P < 0.001), but inversely related to platelet count (P < 0.0001). P-LCR was not associated with the prevalence of CAD (adjusted P = 0.3) or its severity. In addition, P-LCR was not related to Carotid IMT or platelet aggregation in patients with or without aspirin therapy. This study showed that P-LCR is not related to platelet aggregation, aspirin resistance, the extent of CAD and carotid IMT. Thus, P-LCR can not be considered as a marker of platelet reactivity or a risk factor for CAD.
De Luca
Giuseppe
G
Division of Cardiology, Azienda Ospedaliera-Universitaria Maggiore della Carità, Eastern Piedmont University, C.so Mazzini, 18, 28100 Novara, Italy. giuseppe.deluca@maggioreosp.novara.it
Santagostino
Matteo
M
Secco
Gioel Gabrio
GG
Cassetti
Ettore
E
Giuliani
Livio
L
Coppo
Lorenzo
L
Schaffer
Alon
A
Fundaliotis
Angelica
A
Iorio
Sergio
S
Venegoni
Luca
L
Bellomo
Giorgio
G
Marino
Paolo
P
D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology; D010976:Platelet Count; D011446:Prospective Studies; D017539:Tunica Intima / Q000166:cytology / Q000000981:diagnostic imaging*; D017540:Tunica Media / Q000166:cytology* / Q000000981:diagnostic imaging*; D014463:Ultrasonography