[Antidote against local anaesthetic intoxication: new use of lipid emulsion for intravenous administration].
Local anaesthetics are routinely used for several indications, but despite local administration their use may lead to systemic toxicity. The symptoms include numbness of the tongue, dizziness, tinnitus, visual disturbances, muscle spasms, convulsions, coma, and respiratory and cardiac arrest. Recently, an intravenous lipid emulsion was reported to act as a novel potential antidote for systemic toxicity due to local anaesthetics. We describe the application of this lipid emulsion in a 27-year-old patient with generalized seizures and coma due to local anaesthetic toxicity. She recovered quickly and was responsive again 10 minutes after the intravenous administration of the lipid emulsion.
Erasmus MC, afd. Anesthesiologie, Rotterdam, the Netherlands. m.terhorst@erasmusmc.nl
Maarten
M
ter Horst
Gilbert C H
GC
Tjiang
Ronald L
RL
Luitwieler
Chris
C
van Velzen
Robert Jan
RJ
Stolker
Marcel
M
de Quelerij
D000328:Adult; D000779:Anesthetics, Local / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D003128:Coma / Q000139:chemically induced* / Q000188:drug therapy; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D016896:Treatment Outcome
D000779:Anesthetics, Local; D005217:Fat Emulsions, Intravenous