Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: a pilot study.
Xerostomia complaint is very commonly associated to radioactive iodine therapy. Alternatives to treat this morbidity can offer better quality of life to patients with thyroid cancer submitted to adjuvant iodine therapy.


OBJECTIVE
to report on the experience with pilocarpine on the treatment of xerostomia in thyroid cancer patients submitted to adjuvant radioactive iodine therapy (RIT).


METHODS
The five patients who met the inclusion criteria received 5mg of pilocarpine, 3 tid for one week. Side effects of the drug and subjective response to xerostomia complaints after treatment were evaluated.


METHODS
it is a prospective, non-randomized study.


RESULTS
Sudoresis was the most frequent side effect of pilocarpine use, followed by fatigue and headache. Two patients reported relief of xerostomia using pilocarpine, but only one patient was able to tolerate the side effects.


CONCLUSIONS
Pilocarpine seems to relieve xerostomia complaints in thyroid cancer patients because it is able to stimulate salivary flow, but the observed side effects made the patients refuse long-term therapy continuation.
Hospital A. C. Camargo.
Juliana Pereira
JP
Almeida
Luiz Paulo
LP
Kowalski
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008875:Middle Aged; D010862:Pilocarpine / Q000009:adverse effects / Q000627:therapeutic use*; D010865:Pilot Projects; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012469:Salivary Glands / Q000000981:diagnostic imaging / Q000503:physiopathology; D012472:Salivation / Q000187:drug effects; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D016896:Treatment Outcome; D014987:Xerostomia / Q000188:drug therapy*
D007457:Iodine Radioisotopes; D010862:Pilocarpine