[Methods of BMP immobilization and evaluation for Ti-based dental implant surface modification].
Ti-based biomaterial has been widely used as dental and bone implant material although its bioactivity still needs improvement especially for dental implant. The bone morphogenetic proteins(BMPs) bound to Ti-based materials will attract the mesenchymal stem cells to differentiate into osteoblast cells, which benefits the response to the protein-material surface, and finally leads to new bone formation. Several methods including physically mixing, coating, plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials. The latest research papers are focused on the structure and function of BMPs, and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.
Ren
Xiao-shuai
XS
Center for Biomedical Materials and Tissue Engineering Research, Peking University Academy for Advanced Interdisciplinary Studies, Beijing 100871, China.
Wei
Shi-cheng
SC
Su
Xiao-dong
XD
D019485:Bone Morphogenetic Proteins / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D006801:Humans; D055767:Immobilized Proteins / Q000187:drug effects; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology; D019736:Prostheses and Implants; D014025:Titanium / Q000737:chemistry*
D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D055767:Immobilized Proteins; D014025:Titanium