Ion channels as antivirus targets.
Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or cellular activity. We will discuss a group of viral channel proteins that belong to the viroproin family, and which participate in a number of viral functions including promoting the release of viral particles from cells. Blocking these channel-forming proteins may be "lethal", which can be a suitable and potential therapeutic strategy. In this review we discuss seven ion channels of viruses which can lead serious infections in human beings: M2 of influenza A, NB and BM2 of influenza B, CM2 of influenza C, Vpu of HIV-1, p7 of HCV and 2B of picornaviruses.
Liang
Xin
X
State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Li
Zhi-Yuan
ZY
D000998:Antiviral Agents / Q000494:pharmacology*; D054298:Human Immunodeficiency Virus Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors* / Q000502:physiology; D014763:Viral Matrix Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D054334:Viral Regulatory and Accessory Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D000086082:Viroporin Proteins
D000998:Antiviral Agents; D054298:Human Immunodeficiency Virus Proteins; D007473:Ion Channels; D014763:Viral Matrix Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C101758:2B protein, poliovirus; C064964:BM2 polypeptide, influenza B virus; C090877:CM2 protein, Influenza C virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C051094:NB glycoprotein, Influenza B virus; C088369:p7 protein, Hepatitis C virus; C514859:vpu protein, Human immunodeficiency virus 1