Long-term follow-up of a randomized trial comparing laparoscopic and mini-incision open live donor nephrectomy.
Long-term physical and psychosocial effects of laparoscopic and open kidney donation are ill defined. We performed long-term follow-up of 100 live kidney donors, who had been randomly assigned to mini-incision open donor nephrectomy (MIDN) or laparoscopic donor nephrectomy (LDN). Data included blood pressure, glomerular filtration rate, quality of life (SF-36), fatigue (MFI-20) and graft survival. After median follow-up of 6 years clinical and laboratory data were available for 47 donors (94%) in both groups; quality of life data for 35 donors (70%) in the MIDN group, and 37 donors (74%) in the LDN group. After 6 years, mean estimated glomerular filtration rates did not significantly differ between MIDN (75 mL/min) and LDN (76 mL/min, p = 0.39). Most dimensions of the SF-36 and MFI-20 did not significantly differ between groups at long-term follow-up, and most scores had returned to baseline. Twelve percent of the donors reported persistent complaints, but no major complications requiring surgical intervention. Five-year death-censored graft survival was 90% for LDN, and 85% for MIDN (p = 0.50). Long-term outcome of live kidney donation is excellent from the perspective of both the donor and the recipient.
Dols
L F C
LF
Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
Ijzermans
J N M
JN
Wentink
N
N
Tran
T C K
TC
Zuidema
W C
WC
Dooper
I M
IM
Weimar
W
W
Kok
N F M
NF
D000328:Adult; D000368:Aged; D005221:Fatigue / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D006973:Hypertension; D016030:Kidney Transplantation / Q000379:methods; D010535:Laparoscopy / Q000379:methods / Q000523:psychology; D019520:Living Donors / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009392:Nephrectomy / Q000379:methods* / Q000523:psychology; D011788:Quality of Life; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome