In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells.
This in vitro study demonstrates the comparative anti-inflammatory effects of rosiglitazone and 15d-PGJ(2) in endometriosis and provides evidence for exploitation of peroxisome proliferator-activated receptor-γ as a therapeutic target.
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indu
I
Sharma
Veena
V
Dhawan
Subhash Chand
SC
Saha
Lakhbir Kaur
LK
Dhaliwal
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001706:Biopsy; D016022:Case-Control Studies; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004715:Endometriosis / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008070:Lipopolysaccharides / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D015230:Prostaglandin D2 / Q000494:pharmacology; D000077154:Rosiglitazone; D017154:Stromal Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D045162:Thiazolidinediones / Q000494:pharmacology; D014591:Uterine Diseases / Q000473:pathology
D000893:Anti-Inflammatory Agents; D008024:Ligands; D008070:Lipopolysaccharides; D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D015230:Prostaglandin D2