Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.
Department of Pathology, University of Michigan, Ann Arbor, MI 48109-2200, USA. millerr@umich.edu
Richard A
RA
Miller
David E
DE
Harrison
C M
CM
Astle
Joseph A
JA
Baur
Angela Rodriguez
AR
Boyd
Rafael
R
de Cabo
Elizabeth
E
Fernandez
Kevin
K
Flurkey
Martin A
MA
Javors
James F
JF
Nelson
Carlos J
CJ
Orihuela
Scott
S
Pletcher
Zelton Dave
ZD
Sharp
David
D
Sinclair
Joseph W
JW
Starnes
J Erby
JE
Wilkinson
Nancy L
NL
Nadon
Randy
R
Strong
D000375:Aging / Q000187:drug effects / Q000235:genetics; D000818:Animals; D005260:Female; D018740:Genetic Heterogeneity; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D000077185:Resveratrol; D019821:Simvastatin / Q000008:administration & dosage*; D020123:Sirolimus / Q000008:administration & dosage*; D013267:Stilbenes / Q000008:administration & dosage*
D013267:Stilbenes; D019821:Simvastatin; D000077185:Resveratrol; D020123:Sirolimus