Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6.
Cartilage does not form in the tooth extraction socket of the normal rat. The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat. A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only. Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets. Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction. In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage. Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat.
Department of Medical Research and Animal Study, Kaohsiung Military General Hospital, Kaohsiung, Taiwan 823, Republic of China.
Y C
YC
Shyng
C Y
CY
Chi
H
H
Devlin
P
P
Sloan
D000818:Animals; D055418:Bone Morphogenetic Protein 6 / Q000494:pharmacology*; D002356:Cartilage / Q000378:metabolism*; D049109:Cell Proliferation; D002478:Cells, Cultured; D020219:Chondrogenesis; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005455:Fluorescent Antibody Technique; D008963:Molar / Q000601:surgery; D051381:Rats; D013311:Streptozocin; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects* / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
D055418:Bone Morphogenetic Protein 6; D013311:Streptozocin