Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland.
OBJECTIVE
Transcription factor Snail1 has a central role in induction of epithelial-mesenchymal transition (EMT). The aim of the present study was to study the association of Snail1 expression with clinicopathologic factors and prognosis in adenoid cystic carcinoma (ACC) of salivary gland.


METHODS
Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC were retrieved. The Snail1 expression of all these cases was examined by immunohistochemical methods. The association between Snail1 expression and clinicopathologic variables was analyzed using chi-square test, and the prognostic factors were examined by univariate and multivariate analyses.


RESULTS
Our data demonstrated that the positive expression of Snail1 was observed in 58.68% (71/121) of cases. Snail1 expression was significantly associated with histologic pattern, perineural invasion, local regional recurrence, and distant metastasis of patients with ACC (P < .05). And Snail1 expression, local regional recurrence, and distant metastasis were independent and significant prognostic factors in all patients.


CONCLUSIONS
Snail1 may play an important role in the invasion and metastasis of ACC, and Snail1 has the potential for being a strong prognosis indicator at presentation of ACC patients.
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, China.
Jian
J
Jiang
Yaling
Y
Tang
Guiquan
G
Zhu
Min
M
Zheng
Jing
J
Yang
Xinhua
X
Liang
D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000473:pathology* / Q000556:secondary; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology; D000071250:Snail Family Transcription Factors; D015996:Survival Rate; D014157:Transcription Factors / Q000032:analysis*; D016896:Treatment Outcome; D016335:Zinc Fingers / Q000235:genetics*
C000604407:SNAI1 protein, human; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors