APOE genetic associations with seizure development after severe traumatic brain injury.
OBJECTIVE
The purpose of the current study is to assess the role of the APOE genotype in post-traumatic seizure (PTS) development.


METHODS
A retrospective study of 322 adult Caucasians with a severe TBI and APOE genotype.


METHODS
Medical records were searched for PTS. Time to first seizure was categorized as early, late or delayed-onset PTS. Potential PTS associations by genotype, grouped genotype and allele were investigated.


RESULTS
No statistically significant associations were found. However, two out of the four individuals (50%) with the E4/E4 genotype had late/delayed-onset PTS. Furthermore, none with a E2/E2 or E2/E4 genotype seized in the late periods.


CONCLUSIONS
The results of this study may suggest 4/4 as a risk genotype for late/delayed onset PTS and a potential neuroprotective role of the E2 allele. However, this study did not definitively support a role for the APOE genotype in PTS susceptibility and indicates that larger populations are needed to fully evaluate the potential impact of APOE on PTS.
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Megan A
MA
Miller
Yvette
Y
Conley
Joelle M
JM
Scanlon
Dianxu
D
Ren
M
M
Ilyas Kamboh
Christian
C
Niyonkuru
Amy K
AK
Wagner
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D004834:Epilepsy, Post-Traumatic / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000235:genetics*; D055815:Young Adult
D001057:Apolipoproteins E