Propolis: is there a potential for the development of new drugs?
BACKGROUND
Propolis has plenty of biological and pharmacological properties and its mechanisms of action have been widely investigated in the last years, using different experimental models in vitro and in vivo. Researchers have been interested in the investigation of isolated compounds responsible for propolis action; however, there is lack of clinical research on the effects of propolis.
Since propolis-containing products have been marketed and humans have used propolis for different purposes, the goal of this review is to discuss the potential of propolis for the development of new drugs, by comparing data from the literature that suggest candidate areas for the establishment of drugs against tumors, infections, allergy, diabetes, ulcers and with immunomodulatory action.


CONCLUSIONS
The efficacy of propolis in different protocols in vitro and in vivo suggests its therapeutic properties, but before establishing a strategy using this bee product, it is necessary to study: (a) the chemical nature of the propolis sample. (b) Propolis efficacy should be compared to well-established parameters, e.g. positive or negative controls in the experiments. Moreover, possible interactions between propolis and other medicines should be investigated in humans as well. (c) Clinical investigation is needed to evaluate propolis potential in patients or healthy individuals, to understand under which conditions propolis may promote health. Data point out the importance of this research field not only for the readers and researchers in the scientific community waiting for further clarification on the potential of propolis but also for the pharmaceutical industry that looks for new drugs.
Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618-000 Botucatu, SP, Brazil. sforcin@ibb.unesp.br
José Maurício
JM
Sforcin
Vassya
V
Bankova
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy; D055808:Drug Discovery; D020834:Ethnopharmacology; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D007155:Immunologic Factors; D011429:Propolis