Fatal invasive trichosporonosis due to Trichosporon loubieri in a patient with T-lymphoblastic lymphoma.
This study describes the third known human case of an invasive infection caused by Trichosporon loubieri. The 21-year-old patient was suffering from a third relapse of T-lymphoblastic lymphoma and had been in pancytopenia for three months when she developed a blood trichosporonosis. The patient died 10 days later, despite intravenous voriconazole therapy. Final unequivocal identification of the strain was done using molecular biology tools.
C.H.U. de Bordeaux, Laboratoire de Parasitologie-Mycologie, Hôpital Saint André, Bordeaux, France. frederic.gabriel@chu-bordeaux.fr
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Gabriel
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Noel
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Accoceberry
D000935:Antifungal Agents / Q000008:administration & dosage; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D008969:Molecular Sequence Data; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011743:Pyrimidines / Q000008:administration & dosage; D017422:Sequence Analysis, DNA; D014230:Triazoles / Q000008:administration & dosage; D014250:Trichosporon / Q000302:isolation & purification*; D065819:Voriconazole; D055815:Young Adult
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole