Adamantinoma with plasmacytoid features: expanding the spectrum of a diagnostically challenging entity.
Adamantinoma is a rare neoplasm that characteristically involves the tibia. In many instances, typical location within the tibia, very slow course, and a typical radiographic appearance can strongly suggest the correct diagnosis. We present a case that has both unusual radiographic findings and uncharacteristic histology. In this case, radiologic imaging showed a poorly defined lytic lesion within the distal, lateral tibia extending to the joint with central necrosis, overlying periosteal reaction and possible tumor spread into soft tissue. The histology of this lesion showed pronounced vascularity and surrounding large neoplastic cells with plasmacytoid morphology. The combination of these features led to an initial misdiagnosis as metastatic carcinoma from unknown primary.
Walters
Matthew P
MP
Department of Pathology, Medical College of Wisconsin, Milwaukee, 53226, United States. mpwalter@mcw.edu
Baynes
Keith
K
Carrera
Guillermo F
GF
King
David M
DM
Wang
Dian
D
Charlson
John
J
Zambrano
Eduardo
E
D050398:Adamantinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010950:Plasma Cells / Q000473:pathology; D011859:Radiography; D013977:Tibia / Q000473:pathology*
D014408:Biomarkers, Tumor