Retinoic acid-inducible gene-I-like receptors.
Retinoic acid-inducible gene-I (RIG-I), melanoma differentiation-associated 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2) form a family of DExD/H box RNA helicases. RIG-I-like receptors (RLRs) are expressed ubiquitously at low levels, and their expression is induced by treatment with type I interferon (IFN) or a viral infection. RLRs function as sensors for the detection of viral RNA (such as double-stranded RNA) in the cytoplasm to initiate antiviral responses by producing type I and type III IFNs. Unlike Toll-like receptors, which sense exogenous pathogen-associated molecular patterns, RLRs detect cytoplasmic viral RNA. Because RLRs are IFN-inducible viral sensors, they are critical in amplifying antiviral responses.
Onoguchi
Kazuhide
K
Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Yoneyama
Mitsutoshi
M
Fujita
Takashi
T
D000818:Animals; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D007372:Interferons / Q000378:metabolism*; D020365:RNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011971:Receptors, Immunologic; D015398:Signal Transduction; D014777:Virus Diseases / Q000378:metabolism
D011971:Receptors, Immunologic; D007372:Interferons; C520569:DHX58 protein, human; C452820:RIGI protein, human; C452815:IFIH1 protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1; D020365:RNA Helicases