Evaluation of the potential use of adipose-derived mesenchymal stromal cells in the treatment of canine atopic dermatitis: a pilot study.
Stem cells and their potential therapeutic uses in human and veterinary medicine have generated considerable interest. These cells have a number of potentially unique immunologic properties; most notable are their reported regenerative and antiinflammatory capabilities. The aim of this prospective pilot study was to evaluate the efficacy of intravenously administered autogenous adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment of canine atopic dermatitis. AD-MSCs administered intravenously at a dose of 1.3 million cells/kg did not significantly reduce the clinical signs of canine atopic dermatitis or the owner-assessed pruritus level.
Hall
M N
MN
Animal Dermatology Clinic, Tustin, CA 92780, USA.
Rosenkrantz
W S
WS
Hong
J H
JH
Griffin
C E
CE
Mendelsohn
C M
CM
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D000900:Anti-Bacterial Agents; D003876:Dermatitis, Atopic / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D010865:Pilot Projects
D000900:Anti-Bacterial Agents