[Characteristics of developmental regression in autistic children].
OBJECTIVE
About 30% of autistic cases experience developmental regression around 2 years of age. The clinical course and manifestations of autistic children with regression remain unclear. This study investigated the clinical features of a group of autistic children with regression.


METHODS
One hundred and fifty-two children at ages of 2.5-6.5 years confirmed with autism based on DSM-IV diagnostic criteria were enrolled. They were grouped according to language development: normal or regression. The perinatal history, developmental history and characteristics of regression were investigated. The symptoms were compared between the two groups.


RESULTS
Regressions were observed in 33 children (21.7%) at age of between 16 and 21 months, with loss both in communicative skills and social engagement. The regressive group was scored significantly higher on the Childhood Autism Rating Scale (CARS) (P<0.05) and had a relatively higher proportion of severely ill children (66.7% vs 45.4%; P<0.05)compared with the non-regressive group.


CONCLUSIONS
Regression as a characteristic symptom occurs in some autistic children and is of value for diagnosis of autism. The autistic children with regression display more severe social and language impairments than those without regression. Regressive autism may be a special subtype.
Xi
Chun-Yan
CY
Department of Developmental Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. xichy2006@yahoo.com.cn
Hua
Tian-Yi
TY
Zhao
Yun-Jing
YJ
Liu
Xiao-Mei
XM
D001321:Autistic Disorder / Q000175:diagnosis / Q000523:psychology*; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007804:Language Development; D008297:Male; D012919:Social Behavior