[Cardiotoxicity in performing chemotherapy of breast cancer by the data of retrospective multicenter "case-control" investigation].
The authors describe results of 5 year observations of the state of the cardiovascular system in 1643 women who underwent nonajuvant and adjuvant polychemotherapy of breast cancer within the framework of retrospective multicenter case-control investigation. The total frequency of registration of acute cardiotoxicity was 39.3% at standard visits, and 75.2% at unplanned visits. The frequency of late toxicity was 34.5% according to clinical-echocardiography findings, and 100% according to the data of echocardiography of patients with risk factors and markers of cardiotoxicity. The necessity of joint management of such patients by oncologists and cardiologists is stressed.
L Z
LZ
Vel'sher
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AN
Kaziulin
I A
IA
Koroleva
D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors