Endothelin-1: physiological and pathological roles in myometrium.
Endothelin-1 (ET-1), a member of endothelin peptide family is released by many different tissues including uterine smooth muscle. ET-1 acts through ETA and ETB receptors and is implicated in a wide range of biological and pathological functions that explain the great attention of the pharmacological industry for ET-1 receptors as potential therapeutic targets in vascular pathologies and cancers. It is now well established that ET-1 is also able to regulate myometrial functions. In the present review, we focused on ET axis and related signaling pathways involved in the regulation of myometrial contraction, as well as cell proliferation and survival. Such ET-1-mediated cellular functions play a critical role in normal pregnancy, preterm birth and uterine leiomyoma.
Université Paris Sud-11, CNRS, UMR-8619, Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Equipe Signalisation et Régulations Cellulaires, 91400 Orsay, France. Zahra.tanfin@u-psud.fr
Zahra
Z
Tanfin
Denis
D
Leiber
Philippe
P
Robin
Clément
C
Oyeniran
Michelle
M
Breuiller-Fouché
D000595:Amino Acid Sequence; D004194:Disease; D019332:Endothelin-1 / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D009215:Myometrium / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction; D014590:Uterine Contraction
D019332:Endothelin-1