FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.
Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.
Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. fnimmerj@biologie.uni-erlangen.de
Falk
F
Nimmerjahn
Anja
A
Lux
Heike
H
Albert
Melissa
M
Woigk
Christian
C
Lehmann
Diana
D
Dudziak
Patrick
P
Smith
Jeffrey V
JV
Ravetch
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D015551:Autoimmunity; D007074:Immunoglobulin G / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D017452:Receptors, IgG / Q000172:deficiency* / Q000502:physiology
C522404:Fcgr4 protein, mouse; D007074:Immunoglobulin G; D017452:Receptors, IgG