'A mover and a shaker': 53BP1 allows DNA doublestrand breaks a chance to dance and unite.
The DNA damage response mediator protein, p53-binding protein 1 (53BP1), is dispensable for the repair of most DNA doublestrand breaks (DSBs) induced by ionising radiation. However, two recent studies have shown that 53BP1 is required for rejoining of distant DSB ends and that it promotes the movement of uncapped telomeres. These results are discussed in the light of recent findings, and a model for the role of 53BP1 in DSB rejoining is presented.
Goodarzi
Aaron A
AA
Genome Damage and Stability Centre, University of Sussex Brighton, East Sussex BN1 9RQ UK.
Jeggo
Penny A
PA