Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark.
The Annona squamosa L. bark was collected from Ahmednagar district, India. 18-Acetoxy-ent-kaur-16-ene was isolated from petroleum ether extract (PE) and studied for its analgesic and anti-inflammatory activities. 18-Acetoxy-ent-kaur-16-ene at the doses of 12.5 and 25 mg/kg, and PE at a dose of 50 mg/kg exhibited significant analgesic along with anti-inflammatory activity.
Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, India.
M J
MJ
Chavan
P S
PS
Wakte
D B
DB
Shinde
D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D031041:Annona / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D045786:Diterpenes, Kaurane / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement; D010423:Pentazocine / Q000627:therapeutic use; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
C568182:18-acetoxy-ent-kaur-16-ene; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D045786:Diterpenes, Kaurane; D019342:Acetic Acid; D001241:Aspirin; D010423:Pentazocine