SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.
Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.
Neafsey
D E
DE
Broad Institute, Cambridge, MA 02142, USA.
Lawniczak
M K N
MKN
Imperial College London, London SW7 2AZ, UK.
Park
D J
DJ
Broad Institute, Cambridge, MA 02142, USA.
Redmond
S N
SN
Imperial College London, London SW7 2AZ, UK.
Coulibaly
M B
MB
Malaria Research and Training Center, Bamako, Mali.
Traoré
S F
SF
Malaria Research and Training Center, Bamako, Mali.
Sagnon
N
N
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso.
Costantini
C
C
Institut de Recherche pour le Développement, Unité de Recherche R016, Montpellier, France.|Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Yaounde, Cameroon.
Johnson
C
C
Broad Institute, Cambridge, MA 02142, USA.
Wiegand
R C
RC
Broad Institute, Cambridge, MA 02142, USA.
Collins
F H
FH
University of Notre Dame, Notre Dame, IN 46556, USA.
Lander
E S
ES
Broad Institute, Cambridge, MA 02142, USA.
Wirth
D F
DF
Broad Institute, Cambridge, MA 02142, USA.|Harvard School of Public Health, Boston, MA 02115, USA.
Kafatos
F C
FC
Imperial College London, London SW7 2AZ, UK.
Besansky
N J
NJ
University of Notre Dame, Notre Dame, IN 46556, USA.
Christophides
G K
GK
Imperial College London, London SW7 2AZ, UK.
Muskavitch
M A T
MAT
Broad Institute, Cambridge, MA 02142, USA.|Harvard School of Public Health, Boston, MA 02115, USA.|Boston College, Chestnut Hill, MA 02467, USA.
D000818:Animals; D000852:Anopheles / Q000235:genetics*; D005260:Female; D051456:Gene Flow; D017344:Genes, Insect; D005838:Genotype; D007303:Insect Vectors / Q000235:genetics*; D008288:Malaria; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*