Serum vaspin concentrations are decreased after exercise-induced oxidative stress.
Elevated visceral adipose tissue-derived serpin (vaspin) serum concentrations are associated with impaired insulin sensitivity, but increase unexpectedly after long-term physical training. We therefore investigated the effect of an acute exercise bout and the effects of vitamin supplementation on chronic exercise effect and on serum vaspin concentrations. We measured serum vaspin and thiobarbituric acid-reactive substances (TBARS) concentrations in 80 individuals before and after a 1-hour acute exercise bout and independently in 40 healthy young men who were randomly assigned to either antioxidant (vitamin C (1,000 mg/day) and vitamin E (400 IU/day)) or to no supplementation after a standardized 4-week physical training program as a post hoc analysis. Serum vaspin concentrations significantly decreased after acute physical exercise as well as after 4 weeks of training in individuals without antioxidants. Changes in vaspin serum concentration correlate with increased TBARS serum concentrations both in response to a 1-hour exercise bout (r = -0.42, p < 0.01) and to the 4-week training (r = -0.31, p < 0.05). Interestingly, supplementation with antioxidants rather increased circulating vaspin levels in response to 4 weeks of exercise. In conclusion, vaspin serum concentrations are decreased by exercise-induced oxidative stress, but not by exercise-associated improvement in insulin sensitivity.
Department of Medicine, University of Leipzig, Leipzig, Germany.
Andreas
A
Oberbach
Katharina
K
Kirsch
Stefanie
S
Lehmann
Nadine
N
Schlichting
Mathias
M
Fasshauer
Kim
K
Zarse
Michael
M
Stumvoll
Michael
M
Ristow
Matthias
M
Blüher
Peter
P
Kovacs
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D019587:Dietary Supplements; D015536:Down-Regulation; D015444:Exercise / Q000502:physiology*; D005260:Female; D005858:Germany; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015843:Serpins / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*; D055815:Young Adult
D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D017382:Reactive Oxygen Species; C507339:SERPINA12 protein, human; D015843:Serpins; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D014810:Vitamin E; D001205:Ascorbic Acid