Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety.
OBJECTIVE
Topical hemostatic agents are widely used in brain surgery but they have some disadvantages such as foreign body reaction, being a focus for infection and causing artifacts in radiological examinations. The purpose of this study is to compare the effectiveness and safety of microporous polysaccharide hemospheres (MPH) with a well known agent, oxidized regenerated cellulose (ORC), histopathologically and radiologically.


METHODS
Standard brain lesions (4x1mm) were created in 24 hemispheres in 12 New-Zealand rabbits. Animals were divided into three groups; control, ORC and MPH. Twenty-four hours later, all rabbits magnetic resonance brain imaging. After imaging, the animals were sacrificed and the brains were removed for histopathological analysis.


RESULTS
Histopathological analysis showed no significant difference between the groups. Radiological examination showed no significant difference between the MPH and ORC groups in terms of edema but the edema in control group was significantly prominent than MPH and ORC groups (p < 0.001).


CONCLUSIONS
A new agent (MPH) provides safe and effective hemostasis in the brain in this study. The most important advantage of microporous polysaccharide hemospheres is their rapid clearance from the surgical field and therefore having the potential of causing less imaging artifacts.
Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey.
Hakan
H
Emmez
Mehmet
M
Tonge
Nil
N
Tokgoz
Emre
E
Durdag
Ipek
I
Gonul
Necdet
N
Cevıker
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D004195:Disease Models, Animal; D006488:Hemostasis, Surgical / Q000379:methods*; D006490:Hemostatics / Q000494:pharmacology*; D020300:Intracranial Hemorrhages / Q000473:pathology / Q000517:prevention & control*; D008279:Magnetic Resonance Imaging; D009410:Nerve Degeneration / Q000473:pathology / Q000517:prevention & control; D011134:Polysaccharides / Q000494:pharmacology*; D011817:Rabbits
D002483:Cellulose, Oxidized; D006490:Hemostatics; D011134:Polysaccharides