Saliva S100B in professional sportsmen: High levels at resting conditions and increased after vigorous physical activity.
BACKGROUND
Neurological dysfunction is a key medical concern in professional sportsmen (PSM). We investigated whether saliva S100B concentrations in PSM and healthy controls are modified before and after training.


METHODS
We conducted a case-control-study in 75 patients (25 PSM vs 50 controls) in which S100B saliva concentrations were expressed as absolute values and percentage of change (%) from samples drawn before (T0) and after (T1) training.


RESULTS
No differences (P>0.05) between groups were found regarding clinical, monitoring and laboratory parameters. S100B both in PSM and controls was higher at T1 when compared to T0 (P<0.01). In PSM, S100B was higher than controls (P<0.001) at T0 and T1. S100B% at T0-T1 was higher (P<0.001) in PSM and in controls and between PSM and controls (P<0.001).


CONCLUSIONS
Increased saliva S100B levels in PSM before and after training suggest a paracrine/autocrine protein's role connected to stressing activity, which becomes especially evident in PSMs.
Michetti
Fabrizio
F
Institute of Anatomy and Cell Biology, Catholic University, Rome, Italy.
Bruschettini
Matteo
M
Frigiola
Alessandro
A
Abella
Raul
R
Giamberti
Alessandro
A
Marchese
Nora
N
Mangraviti
Salvatore
S
Melioli
Giovanni
G
Baldari
Amedeo
A
Bruschettini
Pierluigi
P
Gazzolo
Diego
D
D016022:Case-Control Studies; D006801:Humans; D009043:Motor Activity; D012146:Rest; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D012463:Saliva
D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins