Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.
A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.
The First Department of Internal Medicine, Gifu University Graduate School of Medicine.
Takeshi
T
Hara
Hisashi
H
Tsurumi
Senji
S
Kasahara
Kengo
K
Ogawa
Jun
J
Takada
Kenji
K
Imai
Koji
K
Takai
Jun-ichi
J
Kitagawa
Shigeru
S
Kiyama
Naoki
N
Imai
Masami
M
Oyama
Tsuyoshi
T
Takami
Hisataka
H
Moriwaki
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017115:Catheter Ablation; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006394:Hemangiosarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006498:Hepatectomy; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D011241:Prednisone / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000627:therapeutic use; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D013921:Thrombocytopenia / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
D007377:Interleukin-3; D011994:Recombinant Proteins; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone