Total synthesis of Phytophthora mating hormone α1.
Total synthesis of Phytophthora mating hormone α1 (1) has been demonstrated. The required stereochemistries (methyl) are achieved by applying CuI-(S)-Tol-BINAP-catalyzed conjugate addition of Grignard reagents to α,β-unsaturated esters.
Wang
Shun-Yi
SY
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Song
Ping
P
Chan
Li-Yan
LY
Loh
Teck-Peng
TP
D002384:Catalysis; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D006728:Hormones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010838:Phytophthora / Q000737:chemistry*; D013237:Stereoisomerism
D004224:Diterpenes; D006728:Hormones; C504077:mating hormone alpha1, Phytophthora