HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discovery.
Human T-cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, was the first human retrovirus to be isolated. It is now the 30(th) anniversary of the initial discovery of HTLV-1. This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression.
Jeang
Kuan-Teh
KT
National Institutes of Health, Bethesda, Maryland 20892, USA. KJEANG@niaid.nih.gov
D002472:Cell Transformation, Viral; D004268:DNA-Binding Proteins / Q000235:genetics; D018450:Disease Progression; D016356:Gene Products, tax / Q000378:metabolism*; D016158:Genes, p53; D016355:Genes, pX; D015490:HTLV-I Infections / Q000378:metabolism / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000821:virology*; D013601:T-Lymphocytes / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D004268:DNA-Binding Proteins; D016356:Gene Products, tax; C478985:PDRG1 protein, human; D016159:Tumor Suppressor Protein p53; C514970:tax protein, Human T-lymphotrophic virus 1