Osteopontin expression in salivary gland carcinomas.
BACKGROUND
In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results.


METHODS
One hundred and seventy-five patients with a primary salivary gland carcinoma diagnosed from January 1, 1990 to December 31, 2005 were identified in the local pathology register, Odense University Hospital. Criteria as documented by Allred et al. were used to assess OPN immunostaining that was performed on surgical specimens.


RESULTS
Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known prognostic factors in salivary gland carcinomas was insignificant.


CONCLUSIONS
Salivary gland carcinomas express OPN. The expression does not correlate with known prognostic factors.
Department of ENT Head and Neck Surgery, Odense University Hospital, Odense, Denmark Department of Pathology, Odense University Hospital, Odense, Denmark. bjoerndal@dadlnet.dk
Kristine
K
Bjørndal
Stine R
SR
Larsen
Christian
C
Godballe
Annelise
A
Krogdahl
D000230:Adenocarcinoma / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism*; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015588:Observer Variation; D053495:Osteopontin / Q000096:biosynthesis*; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D053495:Osteopontin