Postoperative treatment and prognosis of patients with resected single brain metastasis: how useful are established prognostic scores?
OBJECTIVE
To evaluate postoperative prognosis and the performance of known prognostic scores in patients treated with surgical resection for single brain metastasis.


METHODS
We evaluated prognostic factors and five previously published prognostic scores in a group of 74 patients with single brain metastasis treated with surgery with or without immediate whole-brain radiotherapy (WBRT).


RESULTS
In multivariate analysis, good performance status, absence of extracranial metastases and primary tumor control were significantly associated with improved overall survival. Survival (median 10.8 months) was not significantly prolonged by immediate WBRT. Salvage treatment was necessary in 87% of patients without immediate WBRT. All five scores identified groups of patients with superior prognosis. The recursive partitioning analysis (RPA) classes, the graded prognostic assessment (GPA) score and the score developed by Rades et al. identified a poor prognosis group, but the numbers of poor prognosis patients were very small.


CONCLUSIONS
RPA and GPA appear to have the most utility in delineating exceptionally good or poor prognosis patients after resection of single brain metastasis, but this finding remains to be validated in a larger study population. Identification and validation of suitable prognostic scores hopefully will guide decision making regarding local treatment of solitary brain metastasis.
Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway. carsten.nieder@nlsh.no
Carsten
C
Nieder
Sabrina T
ST
Astner
Nikolaus H
NH
Andratschke
Kirsten
K
Marienhagen
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011182:Postoperative Care; D011379:Prognosis; D016634:Radiosurgery; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome