When music and long-term memory interact: effects of musical expertise on functional and structural plasticity in the hippocampus.
The development of musical skills by musicians results in specific structural and functional modifications in the brain. Surprisingly, no functional magnetic resonance imaging (fMRI) study has investigated the impact of musical training on brain function during long-term memory retrieval, a faculty particularly important in music. Thus, using fMRI, we examined for the first time this process during a musical familiarity task (i.e., semantic memory for music). Musical expertise induced supplementary activations in the hippocampus, medial frontal gyrus, and superior temporal areas on both sides, suggesting a constant interaction between episodic and semantic memory during this task in musicians. In addition, a voxel-based morphometry (VBM) investigation was performed within these areas and revealed that gray matter density of the hippocampus was higher in musicians than in nonmusicians. Our data indicate that musical expertise critically modifies long-term memory processes and induces structural and functional plasticity in the hippocampus.
Inserm-EPHE-Université de Caen/Basse-Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France.
Mathilde
M
Groussard
Renaud
R
La Joie
Géraldine
G
Rauchs
Brigitte
B
Landeau
Gaël
G
Chételat
Fausto
F
Viader
Béatrice
B
Desgranges
Francis
F
Eustache
Hervé
H
Platel
D000328:Adult; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D057567:Memory, Long-Term; D009146:Music; D009473:Neuronal Plasticity