Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer.
This study aims to evaluate the role of free/total prostate-specific antigen (PSA) ratio, serum total sialic acid level and cathepsin D activity in the differentiation of prostate cancer and benign prostatic hyperplasia (BPH). The study looked at 100 patients with BPH, 75 patients with organ-confined or locally advanced prostate cancer, and a control group of 50 healthy volunteers. Prostate cancer patients showed significantly higher total sialic acid level and cathepsin D activity and lower free/total PSA ratio than those in the BPH group. The results suggest that combined measurement of serum total sialic acid and/or cathepsin D activity with free/total PSA ratio could serve as a useful adjunct to conventional diagnostics for the differentiation of prostate cancer and BPH.
El Melegy
N T
NT
Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt. elmelegynagla@yahoo.com
Aboulella
H A
HA
Abul-Fadl
A M
AM
Mohamed
N A
NA
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002402:Cathepsin D / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000175:diagnosis*; D011471:Prostatic Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen; D002402:Cathepsin D; D019158:N-Acetylneuraminic Acid