Correlation between vancomycin and daptomycin MIC values for methicillin-susceptible and methicillin-resistant Staphylococcus aureus by 3 testing methodologies.
We examined the potential correlation between vancomycin and daptomycin MIC for 298 Staphylococcus aureus by broth microdilution (BMD), Etest, and MicroScan(®). Etest and BMD identified a significant, albeit poor, correlation between MICs (ρ = 0.29, P < .01, and ρ = 0.15, P = .01, respectively), but no correlation (ρ = 0.08, P = .18) was observed with MicroScan.
Center for Anti-Infective Research and Development, Hartford, CT 06102, USA.
Rebecca A
RA
Keel
Christina A
CA
Sutherland
Jaber
J
Aslanzadeh
David P
DP
Nicolau
Joseph L
JL
Kuti
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D017576:Daptomycin