Ten-year experience of kidney transplantation at the Hospital of Kaunas University of Medicine: demography, complications, graft and patient survival.
During 10 years, 163 cadaveric kidney transplantations were performed at the Hospital of Kaunas University of Medicine. The aim of this study was to analyze the first 10-year experience in kidney transplantation and to evaluate the most frequent early and late complications after transplantation, graft and patient survival, and impact of delayed graft function on graft survival.


METHODS
A total of 159 patients were included into the study. Graft and patient survival was calculated at 1, 3, and 5 years after transplantation using the Kaplan-Meier method; graft function was also analyzed.


RESULTS
Fifty-three patients (33.3%) in the early period and 72 (55.4%) in the late period had at least one episode of urinary tract infection. Less than half (47.2%) of patients had complications related to immunosuppressive treatment, mostly cytomegalovirus infection, in the late period. The risk of CMV reactivation was 3.98 times higher among recipients who received prophylaxis only with intravenous ganciclovir as compared to patients who received valganciclovir after a brief course of ganciclovir (OR, 3.98; 95% CI, 1.48-8.19; P=0.003). Delayed graft function was observed in 53 cases (33.3%); 37 (23.3%) grafts were lost. Graft and patient survival at 1, 3, and 5 years after transplantation was 85%, 82%, and 71% and 97%, 94%, and 94%, respectively. Graft survival at 1, 3, and 5 years was worse among patients with delayed graft function as compared to patients with good graft function (69%, 69%, 50% vs. 93%, 86%, 84%, respectively; P<0.05).


CONCLUSIONS
Urinary tract infection was the most frequent complication after kidney transplantation. Reactivation of cytomegalovirus infection was present only in a quarter of our patients. The administration of valganciclovir was associated with a significantly lower incidence of CMV infection/disease. Graft and patient survival was sufficiently good. Delayed graft function was an independent risk factor for worse graft survival.
Department of Nephrology, Kaunas University of Medicine, Eivenių 2, 50028 Kaunas, Lithuania. egle.dalinkeviciene@gmail.com
Eglė
E
Dalinkevičienė
Vytautas
V
Kuzminskis
Kristina
K
Petrulienė
Inga
I
Skarupskienė
Gintarė
G
Bagdonavičiūtė
Inga Arūnė
IA
Bumblytė
D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002102:Cadaver; D016009:Chi-Square Distribution; D002648:Child; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D006085:Graft Survival; D006785:Hospitals, University; D006801:Humans; D007165:Immunosuppression Therapy; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects; D008097:Lithuania; D008297:Male; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology; D017582:Renal Replacement Therapy; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000453:epidemiology; D000077562:Valganciclovir
D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir