One-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids.
Palladium-catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.
Department of Chemistry, University of South Africa, Pretoria, South Africa. mphahmj@unisa.ac.za
Malose Jack
MJ
Mphahlele
Mamasegare Mabel
MM
Mphahlele
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis; D010165:Palladium / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis*; D014965:X-Rays
D001897:Boronic Acids; D016861:Cyclooxygenase Inhibitors; D011804:Quinolines; D010165:Palladium