Measurement of small intestinal damage.
Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID-induced intestinal lesions as a result of the development of the capsule endoscope and double-balloon endoscope. Ischemic enteritis, one of the most dramatic abdominal emergencies, is known to cause severe damage to the small intestine by a significant decrease of arterial blood flow in the small intestine. In this unit, two animal models for small intestinal damage induced by NSAIDs or intestinal ischemia are described. Also included are methods for lesion induction and evaluation of the damage as well as the measurement of pathogenic functional and biochemical changes.
Kyoto Pharmaceutical University, Kyoto, Japan.
Koji
K
Takeuchi
Hiroshi
H
Satoh
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002415:Cats; D003251:Constriction, Pathologic; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004751:Enteritis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D007410:Intestinal Diseases / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D007421:Intestine, Small / Q000098:blood supply / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology; D008297:Male; D017538:Mesenteric Artery, Superior; D051381:Rats; D012720:Severity of Illness Index
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents