Visual perception and frontal lobe in intellectual disabilities: a study with evoked potentials and neuropsychology.
BACKGROUND
Perception disorders are frequently observed in persons with intellectual disability (ID) and their influence on cognition has been discussed. The objective of this study is to clarify the mechanisms behind these alterations by analysing the visual event related potentials early component, the N1 wave, which is related to perception alterations in several pathologies. Additionally, the relationship between N1 and neuropsychological visual tests was studied with the aim to understand its functional significance in ID persons.


METHODS
A group of 69 subjects, with etiologically heterogeneous mild ID, performed an odd-ball task of active discrimination of geometric figures. N1a (frontal) and N1b (post-occipital) waves were obtained from the evoked potentials. They also performed several neuropsychological tests.


RESULTS
Only component N1a, produced by the target stimulus, showed significant correlations with the visual integration, visual semantic association, visual analogical reasoning tests, Perceptual Reasoning Index (Wechsler Intelligence Scale for Children Fourth Edition) and intelligence quotient.


CONCLUSIONS
The systematic correlations, produced by the target stimulus in perceptual abilities tasks, with the N1a (frontal) and not with N1b (posterior), suggest that the visual perception process involves frontal participation. These correlations support the idea that the N1a and N1b are not equivalent. The relationship between frontal functions and early stages of visual perception is revised and discussed, as well as the frontal contribution with the neuropsychological tests used. A possible relationship between the frontal activity dysfunction in ID and perceptive problems is suggested. Perceptive alteration observed in persons with ID could indeed be because of altered sensory areas, but also to a failure in the frontal participation of perceptive processes conceived as elaborations inside reverberant circuits of perception-action.
Muñoz-Ruata
J
J
Department of Cognitive Neurophysiology, Fundación Promiva, Majadahonda, Madrid, Spain. jorgemruata@icomem.es
Caro-Martínez
E
E
Martínez Pérez
L
L
Borja
M
M
D000293:Adolescent; D058256:Brain Waves / Q000502:physiology; D002648:Child; D004192:Discrimination, Psychological / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*