Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon.
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
Fundação de Medicina Tropical do Amazonas, Brazil.
Wilson M
WM
Ramos Júnior
José F J
JF
Sardinha
Mônica R F
MR
Costa
Marli S
MS
Santana
Maria G C
MG
Alecrim
Marcus V G
MV
Lacerda
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000962:Antimalarials / Q000009:adverse effects*; D005953:Glycogen Storage Disease Type I / Q000150:complications*; D006461:Hemolysis; D006801:Humans; D016780:Malaria, Vivax / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011319:Primaquine / Q000009:adverse effects*
D000962:Antimalarials; D011319:Primaquine