A borylative cyclisation towards indole boronic esters.
2-Alkynylaniline borylative cyclisations provide a direct means to access indole 3-boronic esters from simple precursors. The Pd-catalysed cyclisation can be merged with cross-coupling processes in the same reaction vessel, moreover, the products can be exploited in C-N bond forming reactions.
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Jianhui
J
Huang
Simon J F
SJ
Macdonald
Joseph P A
JP
Harrity
D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D001897:Boronic Acids; D004952:Esters; D007211:Indoles; D010165:Palladium; C030374:indole