Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases.
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Mathias
M
Schelwies
Diana
D
Brinson
Shuhei
S
Otsuki
Young-Hoon
YH
Hong
Martin K
MK
Lotz
Chi-Huey
CH
Wong
Sarah R
SR
Hanson
D001192:Arylsulfatases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000737:chemistry; D057809:HEK293 Cells; D006497:Heparan Sulfate / Q000031:analogs & derivatives; D006801:Humans; D006923:Hymecromone / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D015394:Molecular Structure; D013379:Substrate Specificity; D013429:Sulfatases; D015238:Sulfotransferases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D001192:Arylsulfatases; D004791:Enzyme Inhibitors; D005944:Glucosamine; D006497:Heparan Sulfate; D006923:Hymecromone; D013429:Sulfatases; D015238:Sulfotransferases; C019492:4-methylumbelliferyl sulfate; C470791:SULF1 protein, human; C470792:SULF2 protein, human