Substituted spiro [2.3'] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.
Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 μmol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD.
Ali
Mohamed Ashraf
MA
Pharmacogenetic and Novel Therapeutics Research, Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Pennag, Malaysia. asraf80med@rediffmail.com
Ismail
Rusli
R
Choon
Tan Soo
TS
Yoon
Yeong Keng
YK
Wei
Ang Chee
AC
Pandian
Suresh
S
Kumar
Raju Suresh
RS
Osman
Hasnah
H
Manogaran
Elumalai
E
D000544:Alzheimer Disease / Q000188:drug therapy; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013141:Spiro Compounds; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D011759:Pyrrolidines; D013141:Spiro Compounds