Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the caudate nucleus to participate in pain modulation.
Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to investigate the source of AVP in CdN by the nucleus push-pull perfusion and radioimmunoassay. The results showed that: (1) pain stimulation increased the AVP concentration in the CdN perfusion liquid, (2) PVN decreased the effect of pain stimulation which was stronger in both sides than in one side of PVN cauterization; and (3) L-glutamate sodium would excited the PVN neurons by the PVN microinjection that could increase the AVP concentration in the CdN perfusion liquid. The data suggested that AVP in the CdN might come from the PVN in the pain process, i.e., AVP in the PVN might be transferred to the CdN to participate in the pain modulation.
Yang
Jun
J
School of Pharmacy, Xinxiang Medical University, Xixiang, Henan 453003, China. bcd2009@126.com
Li
Peng
P
Zhang
Xiao-Yi
XY
Zhang
Jing
J
Hao
Fang
F
Pan
Yan-Juan
YJ
Lu
Guang-Zhou
GZ
Lu
Lu
L
Wang
Da-Xin
DX
Wang
Gen
G
Yan
Fu-Lin
FL
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism* / Q000494:pharmacology; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010147:Pain Measurement; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001127:Arginine Vasopressin