Clotting factors and eicosanoids protect against nematode infections.
We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation.
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden.
Pavel
P
Hyrsl
Pavel
P
Dobes
Zhi
Z
Wang
Thomas
T
Hauling
Christine
C
Wilhelmsson
Ulrich
U
Theopold
D000818:Animals; D001777:Blood Coagulation / Q000276:immunology; D001779:Blood Coagulation Factors / Q000378:metabolism* / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D015777:Eicosanoids / Q000378:metabolism* / Q000494:pharmacology; D006458:Hemolymph / Q000378:metabolism; D007113:Immunity, Innate; D020637:Photorhabdus / Q000472:pathogenicity*; D017168:Rhabditida / Q000382:microbiology / Q000472:pathogenicity*; D013559:Symbiosis; D011503:Transglutaminases / Q000378:metabolism* / Q000494:pharmacology
D001779:Blood Coagulation Factors; D015777:Eicosanoids; D011503:Transglutaminases