Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10⁻³ and P = 7.9 × 10⁻³, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10⁻³ and P = 1.5 × 10⁻³, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
Sun
Liang-Dan
LD
Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
Cheng
Hui
H
Wang
Zai-Xing
ZX
Zhang
An-Ping
AP
Wang
Pei-Guang
PG
Xu
Jin-Hua
JH
Zhu
Qi-Xing
QX
Zhou
Hai-Sheng
HS
Ellinghaus
Eva
E
Zhang
Fu-Ren
FR
Pu
Xiong-Ming
XM
Yang
Xue-Qin
XQ
Zhang
Jian-Zhong
JZ
Xu
Ai-E
AE
Wu
Ri-Na
RN
Xu
Li-Min
LM
Peng
Lin
L
Helms
Cynthia A
CA
Ren
Yun-Qing
YQ
Zhang
Chi
C
Zhang
Shu-Mei
SM
Nair
Rajan P
RP
Wang
Hong-Yan
HY
Lin
Guo-Shu
GS
Stuart
Philip E
PE
Fan
Xing
X
Chen
Gang
G
Tejasvi
Trilokraj
T
Li
Pan
P
Zhu
Jun
J
Li
Zhi-Ming
ZM
Ge
Hong-Mei
HM
Weichenthal
Michael
M
Ye
Wen-Zheng
WZ
Zhang
Cheng
C
Shen
Song-Ke
SK
Yang
Bao-Qi
BQ
Sun
Yuan-Yuan
YY
Li
Shan-Shan
SS
Lin
Yan
Y
Jiang
Jian-Hua
JH
Li
Cun-Tao
CT
Chen
Ri-Xin
RX
Cheng
Juan
J
Jiang
Xin
X
Zhang
Peng
P
Song
Wei-Min
WM
Tang
Jin
J
Zhang
Hao-Qin
HQ
Sun
Li
L
Cui
Jing
J
Zhang
Li-Jun
LJ
Tang
Biao
B
Huang
Fei
F
Qin
Qian
Q
Pei
Xiao-Ping
XP
Zhou
Ai-Min
AM
Shao
Li-Mei
LM
Liu
Jian-Lan
JL
Zhang
Feng-Yu
FY
Du
Wei-Dong
WD
Franke
Andre
A
Bowcock
Anne M
AM
Elder
James T
JT
Liu
Jian-Jun
JJ
Yang
Sen
S
Zhang
Xue-Jun
XJ
D000626:Aminopeptidases / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics; D004261:DNA Replication; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D015778:Minor Histocompatibility Antigens; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D064249:Securin; D015843:Serpins / Q000235:genetics; D025521:Tumor Suppressor Proteins; D014481:United States / Q000453:epidemiology
C477880:CSMD1 protein, human; D017630:Connexins; C000607042:GJB2 protein, human; D008565:Membrane Proteins; D015778:Minor Histocompatibility Antigens; D009363:Neoplasm Proteins; C108403:SERPINB8 protein, human; D064249:Securin; D015843:Serpins; D025521:Tumor Suppressor Proteins; C578002:pituitary tumor-transforming protein 1, human; D000072259:Connexin 26; D000626:Aminopeptidases; C464841:ERAP1 protein, human