Bioorthogonal small-molecule ligands for PARP1 imaging in living cells.
Reiner
Thomas
T
Center for Systems Biology, Massachusetts General Hospital, Richard B. Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114, USA.
Earley
Sarah
S
Turetsky
Anna
A
Weissleder
Ralph
R
D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008856:Microscopy, Fluorescence / Q000379:methods*; D015394:Molecular Structure; D010793:Phthalazines / Q000737:chemistry* / Q000494:pharmacology; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport / Q000187:drug effects; D014162:Transfection; D014966:Xanthenes / Q000737:chemistry
D008024:Ligands; D010793:Phthalazines; D010879:Piperazines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D014966:Xanthenes; D049452:Green Fluorescent Proteins; C034657:Texas red; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; C531550:olaparib