Gene profile analysis of CD8(+) ILT3-Fc induced T suppressor cells.
Gene profile analysis of ILT3-Fc-induced Ts revealed a significant upregulation of Zink finger proteins, most of which act as transcriptional repressors. Included among these repressors is BCL6, which was shown to play a critical role in the differentiation of ILT3-Fc-induced T suppressor (Ts) cells. Genes implicated in cell cycle progression were downregulated. Genes encoding numerous inflammatory cytokines and chemokines were also downregulated. In contrast, antiapoptotic genes, as well as members of the WNT and transforming growth factor-β pathways, were upregulated. This study elucidates certain important aspects of Ts differentiation and function.
Vlad
George
G
Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
King
Jessica
J
Chang
Chih-Chao
CC
Liu
Zhuoru
Z
Friedman
Richard A
RA
Torkamani
Ali A
AA
Suciu-Foca
Nicole
N
D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D015536:Down-Regulation / Q000235:genetics; D015870:Gene Expression / Q000276:immunology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000276:immunology; D018816:Genes, cdc; D006084:Graft Rejection / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D008562:Membrane Glycoproteins; D020411:Oligonucleotide Array Sequence Analysis; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use; D011971:Receptors, Immunologic; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D013491:Suppressor Factors, Immunologic / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics
D051017:Apoptosis Regulatory Proteins; C411984:BCOR protein, human; D016207:Cytokines; C107907:LILRB4 protein, human; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D011994:Recombinant Proteins; D012097:Repressor Proteins; D013491:Suppressor Factors, Immunologic; D016212:Transforming Growth Factor beta