R/qtl: high-throughput multiple QTL mapping.
BACKGROUND
R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types. We recently added multiple QTL mapping (MQM) to R/qtl. MQM adds higher statistical power to detect and disentangle the effects of multiple linked and unlinked QTL compared with many other methods. MQM for R/qtl adds many new features including improved handling of missing data, analysis of 10,000 s of molecular traits, permutation for determining significance thresholds for QTL and QTL hot spots, and visualizations for cis-trans and QTL interaction effects. MQM for R/qtl is the first free and open source implementation of MQM that is multi-platform, scalable and suitable for automated procedures and large genetical genomics datasets.


BACKGROUND
R/qtl is free and open source multi-platform software for the statistical language R, and is made available under the GPLv3 license. R/qtl can be installed from http://www.rqtl.org/. R/qtl queries should be directed at the mailing list, see http://www.rqtl.org/list/.


BACKGROUND
kbroman@biostat.wisc.edu.
Arends
Danny
D
Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands.
Prins
Pjotr
P
Jansen
Ritsert C
RC
Broman
Karl W
KW
D002874:Chromosome Mapping / Q000379:methods*; D023281:Genomics; D040641:Quantitative Trait Loci; D012984:Software