Effects of hyperthermic seizures on the developing primary visual cortex of the rat.
Febrile seizures occurring during childhood have been shown to interfere with the development of cognitive functions. However, an alteration of the developing sensory systems might also result from febrile seizures. In order to test this hypothesis, seizures were induced by hyperthermia in Long Evans rats on postnatal day 10. Extracellular single neuron recordings were carried out from postnatal days 15 to 30 and at adulthood. The response of neurons in the primary visual cortex to drifting sinusoidal gratings was recorded in anaesthetized rats. As soon as postnatal day 15, the neurons of rats having experienced a hyperthermic seizure showed significantly lower optimal spatial frequencies (SF), broader directional and temporal bandwidths, as well as higher contrast thresholds than did neurons recorded in normal rats. At adulthood, significantly broader spatial bandwidths and lower optimal temporal frequencies (TF) were obtained from neurons of rats subjected to hyperthermia. These results suggest that febrile seizures during infancy could affect the development of spatio-temporal receptive field properties of neurons in primary visual cortex. Such alterations of a sensory system might contribute to the cognitive deficits associated with early-onset febrile seizures.
Centre de Recherche en Neuropsychologie et Cognition, Département de Psychologie, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, QC, Canada, H3C 3J7.
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Prévost
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Costa
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Carmant
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Lepore
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JP
Guillemot
D000200:Action Potentials / Q000502:physiology; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D015350:Contrast Sensitivity / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D005334:Fever / Q000209:etiology*; D005583:Fourier Analysis; D008297:Male; D009474:Neurons / Q000502:physiology*; D009949:Orientation / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011247:Pregnancy; D051381:Rats; D020318:Rats, Long-Evans; D003294:Seizures, Febrile / Q000150:complications* / Q000473:pathology*; D014793:Visual Cortex / Q000254:growth & development / Q000473:pathology / Q000503:physiopathology; D014794:Visual Fields / Q000502:physiology