Clotting factors and eicosanoids protect against nematode infections.
We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation.
Hyrsl
Pavel
P
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden.
Dobes
Pavel
P
Wang
Zhi
Z
Hauling
Thomas
T
Wilhelmsson
Christine
C
Theopold
Ulrich
U
D000818:Animals; D001777:Blood Coagulation / Q000276:immunology; D001779:Blood Coagulation Factors / Q000378:metabolism* / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D015777:Eicosanoids / Q000378:metabolism* / Q000494:pharmacology; D006458:Hemolymph / Q000378:metabolism; D007113:Immunity, Innate; D020637:Photorhabdus / Q000472:pathogenicity*; D017168:Rhabditida / Q000382:microbiology / Q000472:pathogenicity*; D013559:Symbiosis; D011503:Transglutaminases / Q000378:metabolism* / Q000494:pharmacology
D001779:Blood Coagulation Factors; D015777:Eicosanoids; D011503:Transglutaminases