DNA replication fidelity and cancer.
Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.
Preston
Bradley D
BD
Department of Pathology, University of Washington, Seattle, WA 98195, USA. bradp@u.washington.edu
Albertson
Tina M
TM
Herr
Alan J
AJ
D000818:Animals; D002869:Chromosome Aberrations; D004249:DNA Damage; D053843:DNA Mismatch Repair; D004260:DNA Repair / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism; D015321:Gene Rearrangement; D006801:Humans; D053842:Microsatellite Instability; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D017354:Point Mutation
D004259:DNA-Directed DNA Polymerase