Direct conversion of β-hydroxyketones to cyclic disiloxanes.
β-Hydroxyketones can be directly converted to cyclic disiloxanes using diphenylchlorosilane in the presence of imidazole and an amine base. The reaction is proposed to proceed via a nucleophilic activation mechanism through a cyclic chairlike transition state affording hydrosilylated products with high diastereoselectivity.
Department of Chemistry, Western Washington University, Bellingham, Washington 98225, United States. oneil@chem.wwu.edu
Gregory W
GW
O'Neil
Michael M
MM
Miller
Kyle P
KP
Carter