Calcium signalling: fishing out molecules of mitochondrial calcium transport.
Cellular energy metabolism, survival and death are controlled by mitochondrial calcium signals originating in the cytoplasm. Now, RNAi studies link three proteins - MICU1, NCLX and LETM1 - to the previously unknown molecular mechanism of mitochondrial calcium transport.
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Gyorgy.Hajnoczky@jefferson.edu
György
G
Hajnóczky
György
G
Csordás
D017920:Antiporters / Q000378:metabolism* / Q000502:physiology; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D034622:RNA Interference; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*
D017920:Antiporters; D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; C544264:Letm1 protein, Drosophila; D019831:Sodium-Calcium Exchanger; C034703:mitochondrial calcium uniporter