High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease.
Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) have overlapping gastrointestinal manifestations. Serum antibodies to intestinal microbial antigens in IBD are thought to reflect a loss of tolerance in the setting of genetically encoded innate immune defects. CGD subjects studied here, with or without colitis, had considerably higher levels of ASCA IgA, ASCA IgG, anti-OmpC, anti-I2, and anti-CBir1, but absent to low pANCA, compared to IBD-predictive cutoffs. Higher antibody levels were not associated with a history of colitis. Except for higher ASCA IgG in subjects <18 years, antibody levels were not age-dependent. In comparison, 7 HIES subjects expressed negative to low antibody levels to all of these antigens; none had colitis. Our results suggest that markedly elevated levels of antimicrobial antibodies in CGD do not correlate with a history of colitis but may reflect a specific defect in innate immunity in the face of chronic antigenic stimulation.
Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Joyce E
JE
Yu
Suk See
SS
De Ravin
Gulbu
G
Uzel
Carol
C
Landers
Stephan
S
Targan
Harry L
HL
Malech
Steven M
SM
Holland
Wenqing
W
Cao
Noam
N
Harpaz
Lloyd
L
Mayer
Charlotte
C
Cunningham-Rundles
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood / Q000276:immunology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000908:Antibodies, Fungal / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003092:Colitis / Q000209:etiology* / Q000473:pathology; D003424:Crohn Disease / Q000276:immunology*; D005260:Female; D005408:Flagellin / Q000276:immunology; D006105:Granulomatous Disease, Chronic / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007589:Job Syndrome / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018272:Porins / Q000276:immunology; D011551:Pseudomonas fluorescens / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000276:immunology; D055815:Young Adult
D019268:Antibodies, Antineutrophil Cytoplasmic; D000907:Antibodies, Bacterial; D000908:Antibodies, Fungal; C502160:CBir1 flagellin; C113724:OmpC protein; D018272:Porins; D005408:Flagellin