Effect of chronic mild stress on hippocampal transcriptome in mice selected for high and low stress-induced analgesia and displaying different emotional behaviors.
There is increasing evidence that mood disorders may derive from the impact of environmental pressure on genetically susceptible individuals. Stress-induced hippocampal plasticity has been implicated in depression. We studied hippocampal transcriptomes in strains of mice that display high (HA) and low (LA) swim stress-induced analgesia and that differ in emotional behaviors and responses to different classes of antidepressants. Chronic mild stress (CMS) affected expression of a number of genes common for both strains. CMS also produced strain specific changes in expression suggesting that hippocampal responses to stress depend on genotype. Considerably larger number of genes, biological processes, molecular functions, biochemical pathways, and gene networks were affected by CMS in LA than in HA mice. The results suggest that potential drug targets against detrimental effects of stress include glutamate transporters, and cholinergic, cholecystokinin (CCK), glucocorticoids, and thyroid hormones receptors. Furthermore, some biological processes evoked by stress and different between the strains, such as apoptosis, neurogenesis and chromatin modifications, may be responsible for the long-term, irreversible effects of stress and suggest a role for epigenetic regulation of mood related stress responses.
Department of Molecular Biology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland.
Pawel
P
Lisowski
Grzegorz R
GR
Juszczak
Joanna
J
Goscik
Marek
M
Wieczorek
Lech
L
Zwierzchowski
Artur H
AH
Swiergiel
D000698:Analgesia; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D017209:Apoptosis / Q000235:genetics; D001522:Behavior, Animal; D002454:Cell Differentiation / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D003863:Depression / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D015870:Gene Expression; D020869:Gene Expression Profiling; D006624:Hippocampus / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D055495:Neurogenesis / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D013315:Stress, Psychological / Q000235:genetics* / Q000378:metabolism; D013997:Time Factors
D000928:Antidepressive Agents; D007473:Ion Channels