Cyclophilin A: promising new target in cardiovascular therapy.
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.
Satoh
Kimio
K
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry.
Shimokawa
Hiroaki
H
Berk
Bradford C
BC
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D002319:Cardiovascular System / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D021984:Cyclophilin A / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D018832:Molecular Chaperones; D017382:Reactive Oxygen Species; D020782:Matrix Metalloproteinases; D021984:Cyclophilin A