Targeting thioredoxin reductase: anticancer agents and chemopreventive compounds.
Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductase's C-terminal redox center.
Zeng
H H
HH
School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China. zenghh@bjmu.edu.cn
Wang
L H
LH
D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D017209:Apoptosis; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D010084:Oxidation-Reduction; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013880:Thioredoxin-Disulfide Reductase