Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline.
BACKGROUND
The Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort represents the largest and best-characterized national sample of American youth with recent-onset type 2 diabetes.


OBJECTIVE
The objective of the study was to describe the baseline characteristics of participants in the TODAY randomized clinical trial.


METHODS
Participants were recruited over 4 yr at 15 clinical centers in the United States (n = 704) and enrolled, randomized, treated, and followed up 2-6 yr.


METHODS
The study was conducted at pediatric diabetes care clinics and practices.


METHODS
Eligible participants were aged 10-17 yr inclusive, diagnosed with type 2 diabetes for less than 2 yr and had a body mass index at the 85th percentile or greater.


METHODS
After baseline data collection, participants were randomized to one of the following groups: 1) metformin alone, 2) metformin plus rosiglitazone, or 3) metformin plus a lifestyle program of weight management.


METHODS
Baseline data presented include demographics, clinical/medical history, biochemical measurements, and clinical and biochemical abnormalities.


RESULTS
At baseline the cohort included the following: 64.9% were female; mean age was 14.0 yr; mean diabetes duration was 7.8 months; mean body mass index Z-score was 2.15; 89.4% had a family history of diabetes; 41.1% were Hispanic, 31.5% were non-Hispanic black; 38.8% were living with both biological parents; 41.5% had a household annual income of less than $25,000; 26.3% had a highest education level of parent/guardian less than a high school degree; 26.3% had a blood pressure at the 90th percentile or greater; 13.6% had a blood pressure at the 95th percentile or greater; 13.0% had microalbuminuria; 79.8% had a low high-density lipoprotein level; and 10.2% had high triglycerides.


CONCLUSIONS
The TODAY cohort is predominantly from racial/ethnic minority groups, with low socioeconomic status and a family history of diabetes. Clinical and biochemical abnormalities and comorbidities are prevalent within 2 yr of diagnosis. These findings contribute greatly to our understanding of American youth with type 2 diabetes.
Copeland
Kenneth C
KC
University of Oklahoma College of Medicine, 1200 North Phillips, Suite 4500, Oklahoma City, Oklahoma 73104. kenneth-copeland@ouhsc.edu.
Zeitler
Philip
P
Geffner
Mitchell
M
Guandalini
Cindy
C
Higgins
Janine
J
Hirst
Kathryn
K
Kaufman
Francine R
FR
Linder
Barbara
B
Marcovina
Santica
S
McGuigan
Paul
P
Pyle
Laura
L
Tamborlane
William
W
Willi
Steven
S
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000208:ethnology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000150:complications / Q000208:ethnology / Q000378:metabolism*; D010808:Physical Examination; D011788:Quality of Life
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids