[Nitrogen monoxide monitoring not useful in children with asthma].
Although the Dutch Paediatric Society 2007 practice guideline on asthma in children recommended monitoring of exhaled nitric oxide (FeNO) in the follow-up of children with asthma, a recent systematic review performed by the Dutch Cochrane Centre clearly showed that monitoring FeNO does not improve clinically-relevant asthma outcomes in children. As a result, FeNO monitoring cannot be recommended in the follow-up of children with asthma. This illustrates that many recommendations in evidence-based guidelines are not firmly based on high-quality evidence, but on expert opinion alone. This calls for caution in using such guidelines as standards of care.
Isala Klinieken, Amalia kinderafdeling, Zwolle, the Netherlands. p.l.p.brand@isala.nl
Paul L P
PL
Brand
D000280:Administration, Inhalation; D001249:Asthma / Q000378:metabolism*; D001993:Bronchodilator Agents / Q000032:analysis*; D002648:Child; D005938:Glucocorticoids / Q000008:administration & dosage / Q000032:analysis; D006801:Humans; D009569:Nitric Oxide / Q000032:analysis*
D001993:Bronchodilator Agents; D005938:Glucocorticoids; D009569:Nitric Oxide