Low avidity and level of serum anti-Aβ antibodies in patients with cerebral amyloid angiopathy-related cerebral hemorrhage.
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the beta-amyloid protein (Aβ) in small cerebral vessels, which is considered a common cause of intracerebral hemorrhage (CAAH) in elderly people. Little is known about the properties of serum naturally occurring anti-Aβ antibodies in patients with CAAH. We investigated the avidity and levels of anti-Aβ antibodies in 20 patients and 20 age-matched healthy controls by an enzyme-linked immunosorbent assay with thiocyanate elution. Our study revealed that both the levels and the avidity of these endogenous anti-Aβ antibodies were lower in patients with CAAH than in controls, which may be a new mechanism for the impaired clearance of cerebral Aβ and have important implications for the development of immune-based therapeutic strategies for CAA.
Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College, Neurosurgery Department, Guangzhou, China.
Zhikai
Z
Cao
Jianping
J
Lv
Wei
W
Quan
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000906:Antibodies / Q000097:blood*; D000915:Antibody Affinity; D015984:Causality; D016657:Cerebral Amyloid Angiopathy / Q000097:blood / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D016229:Amyloid beta-Peptides; D000906:Antibodies