What can Drosophila teach us about iron-accumulation neurodegenerative disorders?
The present review focuses on the development and use of Drosophila for modeling neurodegenerative disorders that involve iron accumulation, in particular Friedrich's Ataxia (FRDA) and Neurodegeneration with Iron accumulation (NBIA). Several Drosophila models of such disorders have been introduced successfully in the last few years. Here we review these models and note on the feasibility and advantages of using fly models for understanding the molecular and cellular bases of these devastating diseases.
Bekenstein
Uriya
U
Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat-Ram, 91904, Jerusalem, Israel.
Kadener
Sebastian
S
D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*
D007501:Iron