The NPC-transporter, a ghost in the machine.
Yeast FG nucleoporins are intrinsically disordered proteins that contain cohesive molten globular regions and repulsive extended-coil regions. When placed along the central axis of the NPC, FG nups may self-assemble to create a novel transport channel that provides a series of docking sites for karyopherin-cargo complexes (Yamada et al., 2010).
Akey
Christopher W
CW
Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA. cakey@bu.edu