Developmental biology: a DOR connecting growth and clocks.
DOR, a nuclear receptor co-activator conserved from flies to humans, provides a molecular connection between ecdysone and insulin signaling, two important pathways controlling developmental timing and growth, respectively.
Delanoue
Rénald
R
Institute of Developmental Biology and Cancer, University of Nice-Sophia Antipolis, CNRS, Parc Valrose, Nice, France.
Léopold
Pierre
P
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology; D004331:Drosophila melanogaster / Q000254:growth & development*; D004440:Ecdysone / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological; D011987:Receptors, Steroid / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D004268:DNA-Binding Proteins; C104790:DOR protein, Drosophila; D029721:Drosophila Proteins; D007328:Insulin; D011987:Receptors, Steroid; C055469:ecdysone receptor; D004440:Ecdysone