Neurological impairment and arthritis in an immunocompetent child with human parvovirus B19 chronic infection.
Human parvovirus B19 (HPV-B19) is usually a self-limiting infection in immunocompetent children. In this case report, instead, we describe an immunocompotent child with evidence of persistent HPV-B19 infection, arthritis and neurological impairment. He was first admitted to hospital for HPV-B19 infection and sent home in good clinical condition after anti-inflammatory therapy. Eight months later he was re-admitted to hospital for episodes of arthritis and weakness, myalgia, tremors in his legs and hands, and was unable to walk unaided. In both plasma and serum, HPV-B19 DNA, detected by polymerase chain reaction, was still present. For neurological symptoms, he underwent magnetic resonance, which showed increased signal intensity at the spinal roots in the lumbar region, compatible with polyradiculoneuritis. After immunoglobulin therapy he had an excellent response in clinical and radiological terms, suggesting an association between neurological impairment and HPV-B19 infection. Eleven months after the second admission, the patient was still in good clinical condition.
Bozzola
Elena
E
Ospedale Bambino Gesu, Rome, Italy.
Krzysztofiak
Andrzej
A
Cortis
Eisabetta
E
D000843:Ankle Joint / Q000821:virology*; D001170:Arthritis, Infectious / Q000209:etiology* / Q000628:therapy; D002648:Child; D002908:Chronic Disease; D016731:Erythema Infectiosum / Q000150:complications; D006261:Headache / Q000209:etiology; D006801:Humans; D007121:Immunocompetence; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000276:immunology / Q000628:therapy / Q000821:virology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000628:therapy / Q000821:virology; D012021:Reflex, Abnormal; D014766:Viremia / Q000209:etiology / Q000276:immunology
D016756:Immunoglobulins, Intravenous