The Generation R Study: design and cohort update 2010.
The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. General follow-up rates until the age of 4 years exceed 75%. Data collection in mothers, fathers and preschool children included questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome wide association screen is available in the participating children. Regular detailed hands on assessment are performed from the age of 5 years onwards. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
The Generation R Study Group (AE006), Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl
Vincent W V
VW
Jaddoe
Cock M
CM
van Duijn
Albert J
AJ
van der Heijden
Johan P
JP
Mackenbach
Henriëtte A
HA
Moll
Eric A P
EA
Steegers
Henning
H
Tiemeier
Andre G
AG
Uitterlinden
Frank C
FC
Verhulst
Albert
A
Hofman
D000328:Adult; D002648:Child; D002652:Child Behavior / Q000502:physiology*; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D003071:Cognition; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects; D015340:Epidemiologic Research Design; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics; D055106:Genome-Wide Association Study; D006305:Health Status Indicators; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007407:Interviews as Topic; D008297:Male; D008430:Maternal-Child Health Centers; D009426:Netherlands / Q000453:epidemiology; D010808:Physical Examination / Q000379:methods; D011247:Pregnancy; D011295:Prenatal Care; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D055815:Young Adult