Synthesis and in vitro evaluation of carboxymethyl starch-chitosan nanoparticles as drug delivery system to the colon.
The purpose of this study was to examine chitosan (CS)-carboxymethyl starch (CMS) nanoparticles as drug delivery system to the colon. The 5-aminosalicylic acid (5-ASA) was chosen as model drug molecule. CS-CMS nanoparticles were formulated by a complex coacervation process under mild conditions. The influence of process variables, including the two ionic polymers, on particle size, and nanoparticles entrapment of 5-ASA was studied. In vitro release of 5-ASA was also evaluated, and the integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The release of 5-ASA from nanoparticle was based on the ion-exchange mechanism. The CS-CMS nanoparticles developed based on the modulation of ratio show promise as a system for controlled delivery of drug to the colon.
Saboktakin
Mohammad Reza
MR
Nanostructured Materials Synthesis Lab., International Research Institute of Arian Chemie Gostar, Tabriz, Iran. saboktakin123@yahoo.com
Tabatabaie
Roya M
RM
Maharramov
Abel
A
Ramazanov
Mohammad Ali
MA
D010131:Aminosalicylic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003106:Colon / Q000378:metabolism; D016503:Drug Delivery Systems; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010592:Pharmaceutic Aids / Q000138:chemical synthesis / Q000737:chemistry; D013213:Starch / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D010592:Pharmaceutic Aids; C514968:carboxymethyl-chitosan; D010131:Aminosalicylic Acid; D013213:Starch; D048271:Chitosan; C034848:carboxymethyl starch