Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis.
BACKGROUND
Data on the association between sex hormone receptor polymorphisms and migraine are conflicting.


METHODS
We performed a systematic review and meta-analysis on this topic searching for studies published until August 2009. For each study, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.


CONCLUSIONS
Among the seven genes targeted, four variants were investigated in multiple studies. Effect estimates from an additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine. This pattern does not differ between migraine with and without aura. In contrast, the ESR-1 Pvu II C>T and PGR PROGINS insert polymorphism do not appear to be associated with migraine. Results were driven by studies among Caucasians and may differ in other ethnic groups.
Schürks
Markus
M
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA. mschuerks@rics.bwh.harvard.edu
Rist
Pamela M
PM
Kurth
Tobias
T
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D001141:Aromatase / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics; D000078723:Nuclear Receptor Interacting Protein 1; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011944:Receptors, Androgen / Q000235:genetics; D011962:Receptors, FSH / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D011944:Receptors, Androgen; D011962:Receptors, FSH; D011980:Receptors, Progesterone; D001141:Aromatase