Two-component systems and regulation of developmental progression in Myxococcus xanthus.
Myxococcus xanthus is a prokaryotic model system for multicellular development and cell differentiation. Two-component signal transduction genes are abundant in this organism and the majority is likely organized into complex signaling pathways. This chapter describes in vivo genetic and in vitro biochemical methods used to define signal transduction systems in M. xanthus. We also describe a series of phenotypic analyses utilized to define how a specific set of atypical histidine kinases (HKs) influence progression through the complex developmental program.
Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Bongsoo
B
Lee
Andreas
A
Schramm
Sakthimala
S
Jagadeesan
Penelope I
PI
Higgs
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D000071677:Histidine Kinase; D016941:Myxococcus xanthus / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D011494:Protein Kinases; D000071677:Histidine Kinase