External globus pallidus stimulation modulates brain connectivity in Huntington's disease.
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.
Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. nligot@ulb.ac.be
Noémie
N
Ligot
Pierre
P
Krystkowiak
Clémence
C
Simonin
Serge
S
Goldman
Philippe
P
Peigneux
John
J
Van Naemen
Michel
M
Monclus
Simon Frédéric
SF
Lacroix
David
D
Devos
Kathy
K
Dujardin
Christine
C
Delmaire
Eric
E
Bardinet
Arnaud
A
Delval
Marie
M
Delliaux
Luc
L
Defebvre
Jerome
J
Yelnik
Serge
S
Blond
Alain
A
Destée
Xavier
X
De Tiège
D000328:Adult; D001479:Basal Ganglia / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D046690:Deep Brain Stimulation; D005260:Female; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography; D013788:Thalamus / Q000502:physiology
D010104:Oxygen Radioisotopes