Activity of deferasirox in Mucorales: influences of species and exogenous iron.
Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.
Lewis
Russell E
RE
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.
Pongas
Georgios N
GN
Albert
Nathaniel
N
Ben-Ami
Ronen
R
Walsh
Thomas J
TJ
Kontoyiannis
Dimitrios P
DP
D000935:Antifungal Agents / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D000077588:Deferasirox; D007501:Iron / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009090:Mucorales / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D001565:Benzoates; D014230:Triazoles; D007501:Iron; D000077588:Deferasirox