Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases.
Schelwies
Mathias
M
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Brinson
Diana
D
Otsuki
Shuhei
S
Hong
Young-Hoon
YH
Lotz
Martin K
MK
Wong
Chi-Huey
CH
Hanson
Sarah R
SR
D001192:Arylsulfatases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000737:chemistry; D057809:HEK293 Cells; D006497:Heparan Sulfate / Q000031:analogs & derivatives; D006801:Humans; D006923:Hymecromone / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D015394:Molecular Structure; D013379:Substrate Specificity; D013429:Sulfatases; D015238:Sulfotransferases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D001192:Arylsulfatases; D004791:Enzyme Inhibitors; D005944:Glucosamine; D006497:Heparan Sulfate; D006923:Hymecromone; D013429:Sulfatases; D015238:Sulfotransferases; C019492:4-methylumbelliferyl sulfate; C470791:SULF1 protein, human; C470792:SULF2 protein, human