Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues.
A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O(2) consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.
Department of Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates.
Mariam
M
Al Shamsi
Mohammed T
MT
Al Samri
Suhail
S
Al-Salam
Walter
W
Conca
Sami
S
Shaban
Sheela
S
Benedict
Saeed
S
Tariq
Ankush V
AV
Biradar
Harvey S
HS
Penefsky
Tewodros
T
Asefa
Abdul-Kader
AK
Souid
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D004734:Energy Metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D046529:Microscopy, Electron, Transmission; D010101:Oxygen Consumption; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D001672:Biocompatible Materials; C509968:MCM-41; C509969:SBA-15; D012822:Silicon Dioxide