[Early-onset type 2 diabetes mellitus. The experience from a third level medical institution].
OBJECTIVE
Describe the clinical, metabolic and psychosocial characteristics observed among patients with early onset type 2 diabetes (T2DM).


METHODS
We included 80 consecutive patients with early onset T2DM. All had a medical record, completed a battery of questionnaires and had blood and urine tests.


RESULTS
Mean age was 49 +/- 12 years, 57.5% were women, 76.2% had a family history of diabetes and 68.8% a personal history of obesity. Diabetes was diagnosed at the mean age of 32 +/- 6 years with a mean duration of 17 +/- 11 years. Most patients (66.2%) were on poor glycemic control (Alc > 9.0%) and 30% were depressed. Insulin was commonly needed (80% of the patients) and started on average 9 years after diagnosis Significant diabetes related complications were common (71.3% of patients). A longer diabetes duration was the variable most significantly associated with developing complications (p < 0.00001).


CONCLUSIONS
Patients with early onset T2DM constitute 27.8% of the total number of diabetic patients attending our clinic; they are characterized by a stronger family history of diabetes, a personal history of obesity and co-morbidities associated with metabolic syndrome. Longer disease course and poor glycemic control contribute to a high prevalence of diabetes related complications and high rates of mortality.
Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, DF México. israellerman@gmail.com
Israel
I
Lerman-Garber
Carlos
C
Aguilar-Salinas
Teresa
T
Tusié-Luna
Daniel
D
Velásquez
Marlette
M
Lobato-Valverde
Melannie
M
Osornio-Flores
Francisco J
FJ
Gómez-Pérez
Julio
J
Granados-Arreola
Antonio R
AR
Villa
María Luisa
ML
Velascoa
Juan A
JA
Rull-Rodrigo
D000052:Acanthosis Nigricans / Q000453:epidemiology; D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D015897:Comorbidity; D003627:Data Interpretation, Statistical; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007328:Insulin / Q000627:therapeutic use; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013997:Time Factors
D007328:Insulin