Intrinsic noise and Hill dynamics in the p53 system.
The p53 feedback loop can induce cellular senescence, cell cycle arrest and apoptosis in response to various stresses, including DNA damage, hypoxia and nutrient deprivation. Using a stochastic model of the negative feedback circuit involving p53 and its inhibitor Mdm2, we present the different oscillatory dynamics at the single-cell and population-cell levels as described in the experiments, and the resonant nature of the oscillations is captured. The stationary distributions of protein populations are characterized by non-Gaussian nature which is due to the interplay between time delay and nonlinearity of reactions.
College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China.
Bo
B
Liu
Shiwei
S
Yan
Qi
Q
Wang
D000465:Algorithms; D003198:Computer Simulation; D025461:Feedback, Physiological; D005583:Fourier Analysis; D008954:Models, Biological; D016011:Normal Distribution; D013269:Stochastic Processes; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53