MicroRNAs in cancer: personalizing diagnosis and therapy.
MicroRNAs (miRNAs) are 19-24nt noncoding RNAs that have been implicated in the pathogenesis of both solid and hematological malignancies. Frequently located in fragile chromosomal regions, miRNAs are essential to key biological functions, such as cellular differentiation, apoptosis, and growth. miRNAs may serve as either tumor suppressors or oncogenes. As a result, they have the potential to serve as both biomarkers and therapeutic agents in cancer. Based on our presentation at the recent Towards Personalized Cancer Medicine conference held in Barcelona, Spain, May 19-21, 2010, we provide an overview of the current knowledge of miRNA deregulation in solid and hematological malignancies and their application as biomarkers of disease.
Nana-Sinkam
S Patrick
SP
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio 43210, USA.
Fabbri
Muller
M
Croce
Carlo M
CM
D001943:Breast Neoplasms / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D000090243:Nucleophosmin; D010190:Pancreatic Neoplasms / Q000235:genetics; D057285:Precision Medicine / Q000379:methods*; D015854:Up-Regulation / Q000235:genetics
D035683:MicroRNAs; D009687:Nuclear Proteins; D000090243:Nucleophosmin