Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.
A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.
McIntosh
John A
JA
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Robertson
Charles R
CR
Agarwal
Vinayak
V
Nair
Satish K
SK
Bulaj
Grzegorz W
GW
Schmidt
Eric W
EW
D000595:Amino Acid Sequence; D002384:Catalysis; D003500:Cyclization; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010447:Peptide Hydrolases / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012270:Ribosomes / Q000737:chemistry*
D010455:Peptides; D010447:Peptide Hydrolases