[Toxicological and hygiene characterization of titanium dioxide nanoparticles introduced to the gastrointestinal tract of rats. Communication 1. Integral, biochemical and hematologic indices, small intestinal macromolecule absorption, DNA damage].
Water suspensions of titanium dioxide nanoparticles were introduced intragastrically to growing male Wistar rats daily for 28 days. The data obtained revealed the presence of toxic risks related to said nanomaterials action and demonstrate the necessity of sanitary regulation of titanium dioxide nanoparticles used in food contact materials, cosmetics and other commodity.
Raspolov
R V
RV
Vernikov
V M
VM
Shumakova
A A
AA
Sentsova
T B
TB
Trushina
E N
EN
Mustafina
O K
OK
Kravchenko
L V
LV
Aksenov
I V
IV
Selifanov
A V
AV
Guseva
G V
GV
Avren'eva
L I
LI
Lashneva
N V
NV
Ivanova
G N
GN
Gmoshinskiĭ
I V
IV
Bessonov
V V
VV
Khotimchenko
S A
SA
Tutel'ian
V A
VA
D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D003460:Crystallization; D004249:DNA Damage; D006454:Hemoglobins / Q000032:analysis; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D053758:Nanoparticles / Q000633:toxicity* / Q000648:ultrastructure; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014025:Titanium / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D036401:Toxicity Tests, Chronic
D006454:Hemoglobins; D013438:Sulfhydryl Compounds; C009495:titanium dioxide; D014025:Titanium