The pharmacological therapy of non-variceal upper gastrointestinal bleeding.
The modern management of patients with upper gastrointestinal bleeding includes, in selected patients, the performance of timely multimodal endoscopic hemostasis followed by profound acid suppression. This article discusses the available data on the use of antisecretory regimens in the management of patients with bleeding peptic ulcers, which are a major cause of non-variceal upper gastrointestinal bleeding, and briefly addresses other medications used in this acute setting. The most important clinically relevant data are presented, favoring fully published articles.
Division of Gastroenterology, Montreal General Hospital site, The McGill University Health Center, 1650 Cedar Avenue, Room D16.125, Montréal, Canada.
Joshua
J
Greenspoon
Alan
A
Barkun
D000208:Acute Disease; D005744:Gastric Acid / Q000737:chemistry; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D014148:Tranexamic Acid / Q000009:adverse effects / Q000627:therapeutic use; D041742:Upper Gastrointestinal Tract / Q000187:drug effects
D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D013004:Somatostatin; D014148:Tranexamic Acid