Proximal interphalangeal joint arthritis.
Proximal interphalangeal joint function is critical for proper finger and hand function and arthritis of this joint can lead to considerable hand impairment. Proximal interphalangeal joint arthritides are broadly categorized into nonerosive and erosive osteoarthritis (OA), posttraumatic arthritis, and inflammatory arthritis. The nonerosive type is considered idiopathic or primary OA, whereas the erosive form exhibits an inflammatory component. Idiopathic or primary OA occurs as a consequence of abnormal mechanical stress that leads to damage of cartilage and subchondral bone, with subsequent cytokine and growth factor activation. Individual genetics then mediate the cellular responses. Although erosive OA is described as a separate entity, this remains controversial, with many suggesting that it is merely a more aggressive form of nonerosive, primary OA. Inflammatory OA occurs when connective tissues are diseased, allowing for normal use to incite arthritic damage. Treatment modalities for proximal interphalangeal joint arthritis are currently limited.
Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Benjamin J
BJ
Jacobs
Gust
G
Verbruggen
Robert Alexander
RA
Kaufmann
D018450:Disease Progression; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D010011:Osteocytes / Q000473:pathology; D010014:Osteolysis; D011859:Radiography; D012307:Risk Factors; D012737:Sex Factors