Chromosome segregation: taking the passenger seat.
The chromosomal passenger complex (CPC) is a major regulator of mitotic and meiotic chromosome segregation. Three recent papers now elucidate the mechanisms that determine the localization of the CPC to the inner centromere.
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Gerben
G
Vader
Susanne M A
SM
Lens
D064127:Aurora Kinases; D002503:Centromere / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D008869:Microtubule-Associated Proteins; D046912:Multiprotein Complexes; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases