The renin-angiotensin system and cancer: old dog, new tricks.
For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion of vascular networks are required. There is accumulating molecular and in vivo evidence to indicate that the expression and actions of the renin-angiotensin system (RAS) influence malignancy and also predict that RAS inhibitors, which are currently used to treat hypertension and cardiovascular disease, might augment cancer therapies. To appreciate this potential hegemony of the RAS in cancer, an expanded comprehension of the cellular actions of this system is needed, as well as a greater focus on translational and in vivo research.
George
Amee J
AJ
School of Biomedical Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Thomas
Walter G
WG
Hannan
Ross D
RD
D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000187:drug effects