Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase.
Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in transporting Ca2+ across the cell membranes.
Division of Molecular Medicine, Bose Institute, A.J.C. Bose Centenery Campus, P-1/12, C. I. T. Scheme VII-M, Kolkata 700054, India.
Chinmoy
C
Mukherjee
Swatilekha
S
Ghosh
Pinki
P
Nandi
Parimal C
PC
Sen
Anup Kumar
AK
Misra
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D002236:Carbohydrate Conformation; D002462:Cell Membrane / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006041:Goats; D008297:Male; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D005960:Glucosides; D013450:Sulfones; D000252:Calcium-Transporting ATPases