Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A.
The solid phase total synthesis of the marine cyanobacterial Ahp-cyclodepsipeptide Symplocamide A is reported as a model for a general route for the synthesis of tailor-made non-covalent serine protease inhibitors.
Chemical Genomics Centre der Max-Planck-Gesellschaft, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Sara C
SC
Stolze
Michael
M
Meltzer
Michael
M
Ehrmann
Markus
M
Kaiser
D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010881:Piperidones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
C555955:3-amino-6-hydroxy-2-piperidone; D047630:Depsipeptides; D010881:Piperidones; C527508:symplocamide A