Rate of non-adherence prior to upward dose titration in previously stable antidepressant users.
BACKGROUND
Non-adherence to antidepressant medications is a contributing factor to disease relapse and may result in needless increases in antidepressant dosing.


METHODS
We analyzed de-identified patient claims data from Medco Health Solutions, Inc.'s information database and measured adherence as the medication possession ratio (MPR), with adequate adherence as MPR ≥80%. Adherence was calculated for patients in whom antidepressants were dose escalated and who were on the same antidepressant medication for at least 180 days before the upward dosage titration. Statistical analysis was performed on subgroups comparing adherence with mail vs. retail channels, differences in age and gender, generic prescription vs. brand only, and prescription by psychiatrist vs. non-psychiatrist.


RESULTS
29.7% of patients were non-adherent to their antidepressant medication during the 6 months prior to a prescribed increase in dosage. Non-adherence was significantly lower among patients using the Medco Therapeutic Resource Centers® mail order vs. retail channel. Younger age correlated with poorer adherence. Rates of non-adherence were also significantly greater among women, those receiving generic medications, and among patients with overall lower disease comorbidity. Adherence was not significantly impacted by prescription from a psychiatrist or a non-psychiatrist.


CONCLUSIONS
Retrospective design and use of an administrative patient claims database.


CONCLUSIONS
Suboptimal medication adherence commonly precedes an upward dosage titration of antidepressant medications. Utilization of a mail order channel may improve adherence. Clinicians prescribing antidepressants should explore adherence issues carefully prior to recommending an increase in dosage.
Muzina
David J
DJ
Medco Health Solutions, Inc., Franklin Lakes, NJ, USA. David_Muzina@Medco.com
Malone
Donald A
DA
Bhandari
Inderpal
I
Lulic
Rocco
R
Baudisch
Rich
R
Keene
Matthew
M
D000328:Adult; D000367:Age Factors; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult; D016903:Drug Monitoring
D000928:Antidepressive Agents