Clinical trials update from the European Society of Cardiology Meeting 2010: SHIFT, PEARL-HF, STAR-heart, and HEBE-III.
This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the annual meeting of the European Society of Cardiology held in Stockholm in 2010. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. The SHIFT study supports the use of ivabradine in patients with HF due to left ventricular systolic dysfunction and resting sinus rhythm rate ≥70 b.p.m. despite treatment with beta-blockers or where beta-blockers are contra-indicated. Results from PEARL-HF suggest that the potassium binding polymer RLY5016 may be useful for both prevention and treatment of hyperkalaemia in HF patients with or without concomitant chronic kidney disease. The STAR-heart study provides encouraging observational data about the potential for intracoronary stem cell transplantation in patients with HF. Results from HEBE-III showed no effect of erythropoietin on ejection fraction measured 6 weeks post-MI; although there were fewer cardiovascular events in patients assigned to erythropoietin, the study was too small to provide conclusive evidence of effect.
Department of Cardiology, Hull York Medical School, University of Hull, Daisy Building, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, UK.
John G F
JG
Cleland
Alison P
AP
Coletta
Azam
A
Torabi
Daniyal
D
Ahmed
Andrew L
AL
Clark
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D001552:Benzazepines / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D015897:Comorbidity; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000627:therapeutic use; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D006397:Hematinics / Q000627:therapeutic use; D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D000077550:Ivabradine; D009203:Myocardial Infarction / Q000188:drug therapy; D011108:Polymers / Q000008:administration & dosage / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000188:drug therapy / Q000453:epidemiology; D033581:Stem Cell Transplantation
D000319:Adrenergic beta-Antagonists; D001552:Benzazepines; D054815:Cyclic Nucleotide-Gated Cation Channels; D006397:Hematinics; D011108:Polymers; D004921:Erythropoietin; D000077550:Ivabradine