Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.
Campa
Daniele
D
German Cancer Research Center, DKFZ, Heidelberg, Germany.
Hüsing
Anika
A
Chang-Claude
Jenny
J
Dostal
Lucie
L
Boeing
Heiner
H
Kröger
Janine
J
Tjønneland
Anne
A
Roswall
Nina
N
Overvad
Kim
K
Dahm
Christina C
CC
Rodríguez
Laudina
L
Sala
Núria
N
Pérez
Maria José Sánchez
MJ
Larrañaga
Nerea
N
Chirlaque
Maria-Dolores
MD
Ardanaz
Eva
E
Khaw
Kay-Tee
KT
Wareham
Nick
N
Allen
Naomi E
NE
Travis
Ruth C
RC
Trichopoulou
Antonia
A
Naska
Androniki
A
Bamia
Christina
C
Palli
Domenico
D
Sieri
Sabina
S
Tumino
Rosario
R
Sacerdote
Carlotta
C
van Kranen
Henk J
HJ
Bas Bueno-de-Mesquita
H
H
Stattin
Pär
P
Johansson
Mattias
M
Chajes
Veronique
V
Rinaldi
Sabina
S
Romieu
Isabelle
I
Siddiq
Afshan
A
Norat
Teresa
T
Riboli
Elio
E
Kaaks
Rudolf
R
Canzian
Federico
F
D000328:Adult; D000368:Aged; D064429:Fatty Acid Synthases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013002:Somatomedins / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D013002:Somatomedins; D064429:Fatty Acid Synthases