Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases.
Lennox-Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox-Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide.
Hôpital Henri Gastaut, Centre Saint-Paul, Marseille, France.
Antonella
A
Cuzzola
Edoardo
E
Ferlazzo
Domenico
D
Italiano
Rocco Salvatore
RS
Calabrò
Placido
P
Bramanti
Pierre
P
Genton
D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy; D000078334:Lacosamide; D065768:Lennox Gastaut Syndrome; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy
D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide