Perinatal exposure of rats to Bisphenol A affects fertility of male offspring--an overview.
Endocrine disruptors (ED) induce both functional and behavioral reproductive abnormalities. Bisphenol A (BPA) is a known ED that leaches from polycarbonate plastics, as such human exposure is common. Maternal BPA exposure has been shown to have negative effects on the fertility of male offspring. Pregnant rats exposed perinatally to environmentally relevant doses of BPA gave birth to offspring with significantly impaired spermatogenesis and fertility. Perinatal exposure had deleterious effects on the male germ line which manifested as impairments in the fertility of F(1) male offspring and subsequent F(2) and F(3) generations. This overview is an attempt to summarize the currently available data in the literature with regards to perinatal BPA exposure and male fertility.
National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health (ICMR), Mumbai, Maharashtra, India.
Smita
S
Salian
Tanvi
T
Doshi
Geeta
G
Vanage
D000818:Animals; D001559:Benzhydryl Compounds; D003920:Diabetes Mellitus / Q000139:chemically induced; D044127:Epigenesis, Genetic / Q000187:drug effects*; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000502:physiology; D005837:Genitalia, Male / Q000187:drug effects / Q000473:pathology; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D018811:Maternal Exposure; D009765:Obesity / Q000139:chemically induced; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds