A prospective on drug abuse-associated epigenetics and HIV-1 replication.
Drugs of abuse serve as cofactors to susceptibility to HIV infection and disease progression. Although clinical reports indicate association between HIV/AIDS and drug use, the molecular mechanism of infection susceptibility and disease progression remains unclear. Drugs such as cocaine exert their addictive effects in part by epigenetic mechanisms. Given that epigenetic modifications play an important role in HIV-1 life cycle, it is essential to unravel whether drug abuse-associated epigenetic changes may contribute to HIV/AIDS. In this article we will provide a prospective on the impact of epigenetic mechanisms on HIV-1 life cycle.
Center for AIDS Health Disparities Research and Department of Biochemistry and Cancer Biology, Meharry Medical College School of Medicine, Nashville,TN, USA.
Jui
J
Pandhare
Chandravanu
C
Dash
D057890:Epigenomics; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000235:genetics / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D019966:Substance-Related Disorders / Q000150:complications* / Q000821:virology; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D016662:Virus Integration / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D017735:Virus Latency / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects / Q000235:genetics