Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure.
One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.
Department of Chemical Engineering, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Xujun
X
Wu
Matthew D
MD
Jones
Matthew G
MG
Davidson
Julian B
JB
Chaudhuri
Marianne J
MJ
Ellis
D002460:Cell Line; D006801:Humans; D006813:Humidity; D011098:Polyglactin 910 / Q000737:chemistry*; D012997:Solvents; D013501:Surface-Active Agents / Q000032:analysis*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
D012997:Solvents; D013501:Surface-Active Agents; D011098:Polyglactin 910