Candida albicans PHO81 is required for the inhibition of hyphal development by farnesoic acid.
Farnesoic acid is a signaling molecule that inhibits the transition from budding yeast to filament formation in Candida albicans, but the molecular mechanism regulated by this substance is unknown. In this study, we analyzed the function of CaPHO81, which is induced by farnesoic acid. The pho81Δ mutant cells existed exclusively as filaments under favorable yeast growth conditions. Furthermore, the inhibition of hyphal growth and repression of CPH1, EFG1, HWP1, and GAP1 mRNA expression in response to farnesoic acid were defective in pho81Δ mutant cells. These data suggest a role for CaPHO81 in the inhibition of hyphal development by farnesoic acid.
Chung
Soon-Chun
SC
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of Korea.
Kim
Tae-Im
TI
Ahn
Chan-Hong
CH
Shin
Jongheon
J
Oh
Ki-Bong
KB
D000595:Amino Acid Sequence; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D025301:Hyphae / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D058977:Molecular Sequence Annotation; D017384:Sequence Deletion; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D005656:Fungal Proteins; C007702:farnesoic acid; D018631:ras Proteins