[Memory and epilepsy].
Medial temporal lobe epilepsy is a chronic neurological disease that begins in the early age and that is associated with frequent and disturbing memory deficits. Repeated seizures will lead to the formation of an epileptogenic network that may interfere with physiological neuronal networks and thus with normal brain function: by direct activation or indirectly by deactivation during a seizure, see for example the dreamy state or the ''déja vécu'' phenomenon during temporal seizures; by ictal or post-ictal inhibition, see for example ictal or post-ictal amnesia; by a repetitive and chronic modulation leading to a reorganization of the physiological neuronal networks. The study of these interactions between epileptic and physiological neural networks must lead to better explore the patient's memory and predict memory worsening before temporal lobe surgery and to better understand the reorganization of memory networks in chronic epilepsy. The goal is double: (1) improve the prediction of post-operative memory worsening and guide rehabilitation in epileptic clinical practice; (2) improve the pathophysiological knowledge about memory processes.
Dupont
Sophie
S
D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000523:psychology; D011939:Mental Recall / Q000502:physiology; D009415:Nerve Net; D011183:Postoperative Complications / Q000503:physiopathology / Q000523:psychology; D014054:Tomography; D014057:Tomography, X-Ray Computed