[Vitamin D revisited: a cornerstone of health?].
There is a recent renewed interest in vitamin D metabolism and pathophysiology, due to its recent description as a hormone with a positive impact on global health rather than a strictly bone hormone: vitamin D could be a protective factor against infection, autoimmunity, cardiovascular morbidity, and cancer. By contrast, vitamin D deficiency appears to be increasingly frequent worldwide. We propose a review of these new aspects of vitamin D metabolism, with a focus on vitamin D status in a local pediatric cohort. There is an urgent need for revisiting current guidelines on vitamin D supplementation and for closely monitoring serum vitamin D in children with chronic diseases, i.e., at greater risk of cardiovascular impairment, bone morbidity, infectious disease, and acute inflammation.
David Geffen School of Medicine, UCLA, Los Angeles, USA. justine.bacchetta@chu-lyon.fr
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Bacchetta
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Ranchin
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Dubourg
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Cochat
D001327:Autoimmune Diseases / Q000517:prevention & control; D001424:Bacterial Infections / Q000517:prevention & control; D050071:Bone Density Conservation Agents / Q000378:metabolism* / Q000627:therapeutic use*; D001847:Bone Diseases / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism* / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002648:Child; D002762:Cholecalciferol / Q000378:metabolism / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005602:France / Q000453:epidemiology; D014943:Global Health; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000517:prevention & control; D015995:Prevalence; D012307:Risk Factors; D014777:Virus Diseases / Q000517:prevention & control; D014807:Vitamin D / Q000378:metabolism* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*
D050071:Bone Density Conservation Agents; D014807:Vitamin D; D002762:Cholecalciferol