Strategies for the asymmetric synthesis of H-phosphinate esters.
Access to P-chiral H-phosphinates via desymmetrization of hypophosphite esters was investigated. The use of chiral auxiliaries, chiral catalysts, and of a bulky prochiral group that could lead to kinetic resolution was explored. A chiral NMR assay for enantiomeric excess determination of H-phosphinates was developed. An asymmetric route to C-chiral H-phosphinates is also examined and an assay was developed.
Department of Chemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA.
Karla
K
Bravo-Altamirano
Laëtitia
L
Coudray
Eric L
EL
Deal
Jean-Luc
JL
Montchamp
D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism
D004952:Esters; D063065:Organophosphonates