Two mechanisms that account for major histocompatibility complex restriction of T cells.
In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiate signalling through the TCR complex. Both mechanisms are likely to be essential, but for different reasons.
Kranz
David M
DM
Department of Biochemistry, University of Illinois 600 South Mathews Avenue, Urbana-Champaign, IL 61801 USA. d-kranz@illinois.edu