X-linked agammaglobulinemia complicated with endobronchial tuberculosis.
OBJECTIVE
We report a case of X-linked agammaglobulinemia complicated with endobronchial tuberculosis.


METHODS
We observed the patient's clinical course and analysed his data retrospectively.


RESULTS
Interestingly, the T-cell proliferation activity in this patient was intact, and the CD4-positive T cells produced interferon gamma. However, the result of the quantiferon alpha-2b test was negative.


CONCLUSIONS
The findings of this case suggest that the quantiferon alpha-2b test may not be diagnostic for tuberculosis not only in patients with T-cell disorders but also in cases with B-cell deficiencies such as X-linked agammaglobulinemia.
Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan. ped076@poh.osaka-med.ac.jp
Chihiro
C
Kawakami
Akiko
A
Inoue
Kimitaka
K
Takitani
Hirokazu
H
Kanegane
Toshio
T
Miyawaki
Hiroshi
H
Tamai
D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications / Q000175:diagnosis*; D001982:Bronchial Diseases / Q000150:complications / Q000175:diagnosis*; D005188:False Negative Reactions; D040181:Genetic Diseases, X-Linked / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis*