Adamantinoma with plasmacytoid features: expanding the spectrum of a diagnostically challenging entity.
Adamantinoma is a rare neoplasm that characteristically involves the tibia. In many instances, typical location within the tibia, very slow course, and a typical radiographic appearance can strongly suggest the correct diagnosis. We present a case that has both unusual radiographic findings and uncharacteristic histology. In this case, radiologic imaging showed a poorly defined lytic lesion within the distal, lateral tibia extending to the joint with central necrosis, overlying periosteal reaction and possible tumor spread into soft tissue. The histology of this lesion showed pronounced vascularity and surrounding large neoplastic cells with plasmacytoid morphology. The combination of these features led to an initial misdiagnosis as metastatic carcinoma from unknown primary.
Department of Pathology, Medical College of Wisconsin, Milwaukee, 53226, United States. mpwalter@mcw.edu
Matthew P
MP
Walters
Keith
K
Baynes
Guillermo F
GF
Carrera
David M
DM
King
Dian
D
Wang
John
J
Charlson
Eduardo
E
Zambrano
D050398:Adamantinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010950:Plasma Cells / Q000473:pathology; D011859:Radiography; D013977:Tibia / Q000473:pathology*
D014408:Biomarkers, Tumor