Simulations of lipid vesicle rupture induced by an adjacent supported lipid bilayer patch.
Using a simple phenomenological model of a lipid bilayer and a surface, simulations were performed to study the bilayer-induced vesicle rupture probability as a vesicle adsorbs adjacently to a bilayer patch already adsorbed on the surface. The vesicle rupture probability was studied as a function of temperature, vesicle size, and surface-bilayer interaction strength. From the simulation data, estimates of the apparent activation energy for bilayer-induced vesicle rupture were calculated, both for different vesicle sizes and for different surface-bilayer interaction strengths.
Allerbo
Oskar
O
Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden.
Lundström
Anders
A
Dimitrievski
Kristian
K
D000327:Adsorption; D000465:Algorithms; D001703:Biophysics / Q000379:methods; D003198:Computer Simulation; D008051:Lipid Bilayers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008560:Membrane Fluidity; D008962:Models, Theoretical; D009010:Monte Carlo Method; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature
D008051:Lipid Bilayers; D008055:Lipids