Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis.
OBJECTIVE
To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine.


METHODS
A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain.


RESULTS
The eye showed Acanthamoeba organisms within the cornea and evidence of acute and chronic inflammation throughout the remainder of the eye. The patient has survived without orbital recurrence for 2 years.


CONCLUSIONS
This case demonstrates late inflammation with active Acanthameoba keratitis following systemic pentamidine therapy.
Department of Ophthalmology, The Ohio State University, Columbus, Ohio, USA.
Rebecca A
RA
Kuennen
Reynell Harder
RH
Smith
Thomas F
TF
Mauger
Elson
E
Craig