[The pathways of taurine influences on gastric secretion].
In chronic experiments with dogs with gastric fistulas the influence of amino acid taurine on the gastric secretion was investigated. We showed that taurine did not cause acid gastric secretion out of digestion, but increased the gastric secretion stimulated by histamine, increased the contents of gastric acid and pepsine in gastric secretes. When administered either 15 minutes or two hours prior histamine injection, taurine affected the Na+ and K+ concentrations in gastric juice. The greatest changes in the basic indices of gastric secretion were observed 14 hours after administration of taurine. In these experiments the contents of total proteins and components of adenile system in gastric secretes was increased also. Blockade of cholinoreceptors by atropine, benzohexonium and IEM-1678 decreased the effects of taurine on gastric secretion stimulated by histamine. Blockade of a-adrenoreceptors by phentolamine did not prevent the taurine-induced effects on histamine-stimulated gastric secretion. It is established that under conditions of the blockade of beta-adrenoreceptors by obsidane, taurine does not manifest entirely its potentiating influence on the gastric secretion stimulating by histamine. The data obtained indicate that taurine affects gastric secretion stimulated by histamine and realization of this effect occurs through M- and N-cholino- and B-adrenoreceptors.
O A
OA
Hrinchenko
P I
PI
Ianchuk
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004285:Dogs; D005508:Food Deprivation; D005747:Gastric Fistula / Q000378:metabolism; D005750:Gastric Juice / Q000737:chemistry* / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D018680:Cholinergic Antagonists; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D013654:Taurine; D006632:Histamine