Cyclophilin A: promising new target in cardiovascular therapy.
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry.
Kimio
K
Satoh
Hiroaki
H
Shimokawa
Bradford C
BC
Berk
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D002319:Cardiovascular System / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D021984:Cyclophilin A / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D018832:Molecular Chaperones; D017382:Reactive Oxygen Species; D020782:Matrix Metalloproteinases; D021984:Cyclophilin A