Copper-catalyzed cross dehydrogenative coupling reactions of tertiary amines with ketones or indoles.
A novel cross dehydrogenative coupling (CDC) reaction of N,N-dimethylanilines with methyl ketones by cooperative copper and aminocatalysis has been developed, which leads to the formation of β-arylamino ketones in 42-73% yields. Moreover, the copper-catalyzed alkylation of free (NH) indoles with N,N-dimethylanilines via CDC reaction is also presented, affording alkylated indoles in 52-78% yields.
Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry, and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
Fei
F
Yang
Jian
J
Li
Jin
J
Xie
Zhi-Zhen
ZZ
Huang