Breast cancer genomics: normal tissue and cancer markers.
Mammography is a powerful screening tool for early detection of breast cancer, but it has limitations in terms of both specificity and sensitivity. Imaging tools such as MRI that complement mammography are too costly to serve as first-line screens. Recently, progress has been made on blood markers, particularly microRNAs and proteins. There are new methods for protein marker discovery directly in blood, but they are limited in the number of patients that can be examined. An alternative is to discover markers as transcripts in tissues, followed by development of blood protein tests for those that perform best. To identify genes that are overexpressed in malignancy it is paramount to include normal control tissues from healthy individuals. Here we report the identification of potential breast cancer markers, including some that are overexpressed in aggressive disease.
Schummer
Michèl
M
Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. mschumme@fhcrc.org
Beatty
David
D
Urban
Nicole
N
D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008403:Mass Screening; D035683:MicroRNAs / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D012016:Reference Values; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
D014408:Biomarkers, Tumor; D005819:Genetic Markers; D035683:MicroRNAs; D012334:RNA, Neoplasm