Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10⁻³ and P = 7.9 × 10⁻³, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10⁻³ and P = 1.5 × 10⁻³, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
Liang-Dan
LD
Sun
Hui
H
Cheng
Zai-Xing
ZX
Wang
An-Ping
AP
Zhang
Pei-Guang
PG
Wang
Jin-Hua
JH
Xu
Qi-Xing
QX
Zhu
Hai-Sheng
HS
Zhou
Eva
E
Ellinghaus
Fu-Ren
FR
Zhang
Xiong-Ming
XM
Pu
Xue-Qin
XQ
Yang
Jian-Zhong
JZ
Zhang
Ai-E
AE
Xu
Ri-Na
RN
Wu
Li-Min
LM
Xu
Lin
L
Peng
Cynthia A
CA
Helms
Yun-Qing
YQ
Ren
Chi
C
Zhang
Shu-Mei
SM
Zhang
Rajan P
RP
Nair
Hong-Yan
HY
Wang
Guo-Shu
GS
Lin
Philip E
PE
Stuart
Xing
X
Fan
Gang
G
Chen
Trilokraj
T
Tejasvi
Pan
P
Li
Jun
J
Zhu
Zhi-Ming
ZM
Li
Hong-Mei
HM
Ge
Michael
M
Weichenthal
Wen-Zheng
WZ
Ye
Cheng
C
Zhang
Song-Ke
SK
Shen
Bao-Qi
BQ
Yang
Yuan-Yuan
YY
Sun
Shan-Shan
SS
Li
Yan
Y
Lin
Jian-Hua
JH
Jiang
Cun-Tao
CT
Li
Ri-Xin
RX
Chen
Juan
J
Cheng
Xin
X
Jiang
Peng
P
Zhang
Wei-Min
WM
Song
Jin
J
Tang
Hao-Qin
HQ
Zhang
Li
L
Sun
Jing
J
Cui
Li-Jun
LJ
Zhang
Biao
B
Tang
Fei
F
Huang
Qian
Q
Qin
Xiao-Ping
XP
Pei
Ai-Min
AM
Zhou
Li-Mei
LM
Shao
Jian-Lan
JL
Liu
Feng-Yu
FY
Zhang
Wei-Dong
WD
Du
Andre
A
Franke
Anne M
AM
Bowcock
James T
JT
Elder
Jian-Jun
JJ
Liu
Sen
S
Yang
Xue-Jun
XJ
Zhang
D000626:Aminopeptidases / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics; D004261:DNA Replication; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D015778:Minor Histocompatibility Antigens; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D064249:Securin; D015843:Serpins / Q000235:genetics; D025521:Tumor Suppressor Proteins; D014481:United States / Q000453:epidemiology
C477880:CSMD1 protein, human; D017630:Connexins; C000607042:GJB2 protein, human; D008565:Membrane Proteins; D015778:Minor Histocompatibility Antigens; D009363:Neoplasm Proteins; C108403:SERPINB8 protein, human; D064249:Securin; D015843:Serpins; D025521:Tumor Suppressor Proteins; C578002:pituitary tumor-transforming protein 1, human; D000072259:Connexin 26; D000626:Aminopeptidases; C464841:ERAP1 protein, human