Risk factors for immune reconstitution inflammatory syndrome under combination antiretroviral therapy can be aetiology-specific.
In order to discriminate general from aetiology-specific risk factors for immune reconstitution inflammatory syndrome (IRIS), we followed up, during six months, 99 patients with advanced HIV infection commencing antiretroviral therapy (ART) without active opportunistic infections or evident inflammation. IRIS predictors were determined by univariate analysis using clinical data from 76 ART-responding patients either completing follow-up or developing IRIS, and by multivariate analysis of inflammation, disease progression and nutrition status variables. We identified 23 primary IRIS events (30.3%). Univariate predictors for all IRIS events were higher platelet counts and lower CD4/CD8 ratio, whereas subclinical inflammation was the multivariate predictor. Platelets, alkaline phosphatase levels and %CD8 T-cells in univariate analysis also predicted mycobacteria-associated IRIS independently, remaining elevated during follow-up. Herpesvirus IRIS was predicted by platelets and inflammation. Indicators of advanced HIV disease and subclinical inflammation jointly predict IRIS, and some are specific of the underlying microbial aetiology, possibly explaining previous reports.
Center for Infectious Diseases Research (CIENI), Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Mexico City, Mexico.
E
E
Espinosa
C E
CE
Ormsby
R S
RS
Vega-Barrientos
M
M
Ruiz-Cruz
G
G
Moreno-Coutiño
A
A
Peña-Jiménez
A B
AB
Peralta-Prado
M
M
Cantoral-Díaz
D P
DP
Romero-Rodríguez
G
G
Reyes-Terán
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D016516:CD4-CD8 Ratio; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006564:Herpesviridae / Q000276:immunology / Q000472:pathogenicity; D006566:Herpesviridae Infections / Q000276:immunology / Q000473:pathology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000453:epidemiology* / Q000209:etiology* / Q000382:microbiology / Q000821:virology; D008297:Male; D009161:Mycobacterium / Q000276:immunology / Q000472:pathogenicity; D010976:Platelet Count; D012307:Risk Factors; D014376:Tuberculosis / Q000276:immunology / Q000473:pathology
D044966:Anti-Retroviral Agents