Prevalence of mild cognitive impairment and its subtypes in the Heinz Nixdorf Recall study cohort.
OBJECTIVE
We investigated the prevalence of mild cognitive impairment (MCI) and its subtypes according to the original (MCI-original) and modified (MCI-modified; neglecting cognitive complaints) Petersen criteria.


METHODS
4,145 subjects (aged 50-80 years) from a German population-based study completed a cognitive screening test and were poststratified into 2 groups with sample sizes of 1,125 for impaired and 3,020 for age-appropriate performance. Random samples of 445 impaired participants and 211 age-appropriate participants received a detailed neuropsychological evaluation. The prevalence of MCI was estimated by a bias correction estimator based on stratum weights. The association between MCI and age, gender and education was analyzed in a logistic regression model.


RESULTS
The estimated MCI prevalence was 7.8% (95% CI: 5.7-9.9%) for the original, and 12.1% (95% CI: 9.8-14.4%) for the modified criteria. In the MCI-original group, amnestic MCI subtypes were slightly less common than non-amnestic MCI subtypes (3.5 vs. 4.3%). MCI-original was associated with lower education and older age. In the MCI-modified group, the amnestic subtypes were more common than the non-amnestic MCI subtypes (7.8 vs. 4.3%), and MCI was associated with age, gender and education.


CONCLUSIONS
Prevalence rates of MCI are high in the general population and vary considerably according to the criteria applied.
Dlugaj
Martha
M
Department of Neurology, University Hospital Essen, Essen, Germany. Martha.Dlugaj@uk-essen.de
Weimar
Christian
C
Wege
Natalia
N
Verde
Pablo Emilio
PE
Gerwig
Marcus
M
Dragano
Nico
N
Moebus
Susanne
S
Jöckel
Karl-Heinz
KH
Erbel
Raimund
R
Siegrist
Johannes
J
D017677:Age Distribution; D000368:Aged; D000647:Amnesia / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D003072:Cognition Disorders / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D015331:Cohort Studies; D003704:Dementia / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D012042:Registries; D017678:Sex Distribution