Insider influence on ErbB activity.
The receptor tyrosine kinase ErbB is activated by ligand-induced dimerization, leading to transphosphorylation of the cytoplasmic kinase domains. Bill et al. (2010) now demonstrate that transphosphorylation can be modulated from within the cell by the cytoplasmic protein cytohesin, providing new insights into ErbB-dependent processes during normal development and cancer.
Shilo
Ben-Zion
BZ
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. benny.shilo@weizmann.ac.il