T-lineage lymphoblastic lymphoma and leukemia-a MASSive problem.
T cell precursor malignancies may present as T-lymphoblastic lymphoma (T-LBL) with marked enlargement of lymph nodes or acute T-lymphoblastic leukemia (T-ALL) with little lymph node enlargement. In this issue of Cancer Cell, Feng et al. show that dysregulation of BCL2, AKT signaling, and cell adhesion pathways are hallmarks of T-LBL.
Mullighan
Charles G
CG
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. charles.mullighan@stjude.org