Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC₅₀ value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC₅₀ value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.
Chen
Yu
Y
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China.
Fan
Hua
H
Yang
Guang-Zhong
GZ
Jiang
Yan
Y
Zhong
Fang-Fang
FF
He
Hong-Wu
HW
D001713:Biphenyl Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D029760:Garcinia / Q000033:anatomy & histology / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D054876:Prenylation; D044004:Xanthones / Q000737:chemistry*
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D007202:Indicators and Reagents; D010851:Picrates; D010936:Plant Extracts; D044004:Xanthones; C004931:1,1-diphenyl-2-picrylhydrazyl