[Expression of MRP gene in non-small cell lung cancer and its significance].
BACKGROUND
To investigate the effects of multi-drug resistance associated protein gene (MRP gene) overexpression on the prognosis of patients with non-small cell lung cancer (NSCLC) .


METHODS
Paraffin-embedded cancer tissues from 47 cases of NSCLC who had undergone radical resection were determined for expression of MRP gene mRNA by in situ hybridization combined with immunohistochemistry and all the patients had been followed up.


RESULTS
All of 47 lung cancer specimen were found to have overexpression of MRP gene mRNA and the overexpression was closely related to survival time and recurrence or metastasis after surgery , but not to the clinical pathological factors.


CONCLUSIONS
MRP gene is related with the prognosis of lung cancer patients and may be regarded as indicator to predict the prognosis and to choose suitable chemotherapy for non-small cell lung cancer patients.
Department of Thoracic Surgery , Xinhua Hospital , Shanghai Second Medical University , Shanghai 200092 , P. R. China.
G
G
Shan
H
H
Zhong
F
F
Zhang