Neuropsychological correlates of mild to severe hallucinations in Parkinson's disease.
The development of visual hallucinations (VH) is a frequent complication of Parkinson's disease (PD). Presence of hallucinations is one of the main risk factors associated with dementia, and severity progression of VH mainly contributes to impaired quality of life in PD. The neuropsychological features associated with severity progression of VH are unknown and might help to detect patients at risk of a more severe outcome. We aimed to explore the neuropsychological deficits associated with the different types of VH observed in PD, from minor hallucinations to well-formed VH with loss of insight. Prospective study of 57 PD patients with (n = 29) and without VH (n = 28) matched for age, education, antiparkinsonian medications, and disease duration. Description of VH was assessed by the Hallucinations and Psychosis item of the MDS-UPDRS. Cognition was assessed with the Parkinson's Disease-Cognitive Rating Scale (PD-CRS) and the Mattis Dementia Rating Scale (MDRS). Patients with minor VH did not differ from patients without VH in any cognitive domain. PD patients with major VH and insight retained performed worse on the action verbal fluency task (P < 0.04), and patients with VH and loss of insight showed a greater impairment on the PD-CRS posterior cortical score (P = 0.021) and the clock copying item (P = 0.01). A double dissociation was found in the neuropsychological profile of patients with VH with and without loss of insight. While the presence of major VH with insight retained appeared related to a predominant frontal-striatal impairment, loss of insight was characterized by further impairment of cognitive functions related to posterior cortical areas. A comprehensible continuum pattern of clinical relationships emerged among VH and cognitive functioning in PD.
Movement Disorders Unit, Neurology Department, Sant Pau Hospital (Sant Pau Institute of Biomedical Research), Autonomous University of Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
Gisela
G
Llebaria
Javier
J
Pagonabarraga
Mercè
M
Martínez-Corral
Carmen
C
García-Sánchez
Berta
B
Pascual-Sedano
Alexandre
A
Gironell
Jaime
J
Kulisevsky
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D006212:Hallucinations / Q000150:complications* / Q000523:psychology*; D006801:Humans; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors