Substituted spiro [2.3'] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.
Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 μmol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD.
Pharmacogenetic and Novel Therapeutics Research, Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Pennag, Malaysia. asraf80med@rediffmail.com
Mohamed Ashraf
MA
Ali
Rusli
R
Ismail
Tan Soo
TS
Choon
Yeong Keng
YK
Yoon
Ang Chee
AC
Wei
Suresh
S
Pandian
Raju Suresh
RS
Kumar
Hasnah
H
Osman
Elumalai
E
Manogaran
D000544:Alzheimer Disease / Q000188:drug therapy; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013141:Spiro Compounds; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D011759:Pyrrolidines; D013141:Spiro Compounds