Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers.
A novel proton-fueled molecular gate-like delivery system has been constructed for controlled cargo release using i-motif quadruplex DNA as caps onto pore outlets of mesoporous silica nanoparticles. Start from simple conformation changes, the i-motif DNA cap can open and close the pore system in smart response to pH stimulus. Importantly, the opening/closing and delivery protocol is highly reversible and a partial cargo delivery can be easily controlled at will. A pH-switchable nanoreactor has also been developed to validate the potential of our system for on-demand molecular transport. This proof of concept might open the door to a new generation of carrier materials and could also provide a general route to use other functional nucleic acids/peptide nucleic acids as capping agents in the fields of versatile controlled delivery nanodevices.
Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
Cuie
C
Chen
Fang
F
Pu
Zhenzhen
Z
Huang
Zhen
Z
Liu
Jinsong
J
Ren
Xiaogang
X
Qu
D004247:DNA / Q000737:chemistry; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes / Q000032:analysis; D054856:G-Quadruplexes; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011522:Protons; D012235:Rhodamines / Q000032:analysis; D012822:Silicon Dioxide / Q000737:chemistry*
D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D011522:Protons; D012235:Rhodamines; D012822:Silicon Dioxide; D004247:DNA; C029773:rhodamine B