Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma.
The prognosis of high-risk rhabdomyosarcoma (RMS) with metastatic or recurrent disease remains poor. We report a 6-year-old girl who successfully underwent allogeneic hematopoietic stem cell transplantation against recurrent metastatic alveolar RMS. The disease recurred at distant lymph node metastasis with bone marrow involvement. After chemotherapy and radiotherapy for the metastatic site, she underwent allogeneic bone marrow transplantation during complete remission from her 5/8 HLA-matched father. She developed acute graft-versus-host disease after preemptive donor lymphocyte infusion and remains in a disease-free condition for 31 months after transplantation. A graft-versus-tumor effect through allogeneic immune cells might produce a beneficial effect for high-risk RMS.
Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan. ohta@ped.med.osaka-u.ac.jp
Hideaki
H
Ohta
Yoshiko
Y
Hashii
Hisao
H
Yoshida
Shigenori
S
Kusuki
Sadao
S
Tokimasa
Akihiro
A
Yoneda
Masahiro
M
Fukuzawa
Nami
N
Inoue
Junichi
J
Hara
Takeshi
T
Kusafuka
Keiichi
K
Ozono
D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011379:Prognosis; D012008:Recurrence; D018232:Rhabdomyosarcoma, Alveolar / Q000175:diagnosis / Q000556:secondary / Q000628:therapy*; D014184:Transplantation, Homologous