Repeat recognition.
CUG-binding protein 1 (CUGBP1) is a ubiquitous RNA-binding protein implicated in altered RNA metabolism linked to myotonic dystrophy type 1. Crystal structures of the RRM domains in complex with cognate RNAs (Teplova et al., 2010) reveal molecular details for the selectivity of CUGBP1 toward GU-rich mRNA elements.
Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Konstantinos
K
Tripsianes
Michael
M
Sattler