Iron-facilitated direct oxidative C-H transformation of allylarenes or alkenes to alkenyl nitriles.
This paper describes the first direct approach to alkenyl nitriles from allylarenes or alkenes facilitated by an inexpensive homogeneous iron catalyst. Three C-H bond cleavages occur under the mild conditions during this process. Mechanistic studies indicate that the cleavage of the allyl C(sp(3))-H bond is involved in the rate-determining step. This observation may provide an opportunity to achieve C(sp(3))-H functionalization catalyzed by an iron catalyst.
Qin
Chong
C
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
Jiao
Ning
N
D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D009570:Nitriles / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
D000475:Alkenes; D009570:Nitriles; D002244:Carbon; D006859:Hydrogen; D007501:Iron