Role of oxidant scavengers in the prevention of Ca²+ homeostasis disorders.
A number of disorders, such as Alzheimer disease and diabetes mellitus, have in common the alteration of the redox balance, resulting in an increase in reactive oxygen species (ROS) generation that might lead to the development of apoptosis and cell death. It has long been known that ROS can significantly alter Ca²+ mobilization, an intracellular signal that is involved in the regulation of a wide variety of cellular functions. Cells have a limited capability to counteract the effects of oxidative stress, but evidence has been provided supporting the beneficial effects of exogenous ROS scavengers. Here, we review the effects of oxidative stress on intracellular Ca²+ homeostasis and the role of antioxidants in the prevention and treatment of disorders associated to abnormal Ca²+ mobilization induced by ROS.
Galan
Carmen
C
Cell Physiology Research Group, Department of Physiology, University of Extremadura, Caceres 10071, Spain.
Jardín
Isaac
I
Dionisio
Natalia
N
Salido
Ginés
G
Rosado
Juan A
JA
D000975:Antioxidants / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism / Q000503:physiopathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D002118:Calcium