Large fetal goiter due to placental passage of maternal antithyroperoxidase antibodies.
We report a case of fetal goiter in a pregnant woman with Graves-Basedow disease. It was diagnosed in the third trimester by a routine ultrasound, and the cordocentesis verified increased levels of thyroxine (T4) and increased autoantibodies (antithyroperoxidase antibodies) that were also increased in maternal blood. Fetal goiter got smaller on the follow-up scans, and the newborn presented hypothyroidism. Current notions on the diagnosis and management of fetal goiter are briefly discussed.
Vico
Irene
I
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada, Spain.
Molina
Francisca S
FS
Alarcón-Blanco
Pedro
P
Durán
Santiago
S
Azumendi
Guillermo
G
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000276:immunology*; D006042:Goiter / Q000000981:diagnostic imaging / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D021041:Placental Circulation; D011247:Pregnancy; D014463:Ultrasonography
D001323:Autoantibodies