Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma.
We report the case of a child presenting with concurrent thoracic ganglioneuroblastoma and acute myeloid leukemia. The peculiarity was the close relation between the two tumors with the latter infiltrating the former one. Histological and genomic studies indicate the different clonal origins of the malignancies in the patient, and we hypothesized that GNB and AML developed independently. Our observation suggests that in patients with more than one tumor, though discovered at different times, one neoplasm is not always secondary.
Department of Paediatric Haematology and Oncology, University of Catania, Catania, Italy. adicata@unict.it
Andrea
A
Di Cataldo
Katia
K
Mazzocco
Gaetano
G
Magro
Elena
E
Mirabile
Luca
L
Lo Nigro
Raffaella
R
Defferrari
Gian Paolo
GP
Tonini
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D018305:Ganglioneuroblastoma / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology