Comparative activity of telavancin and other antimicrobial agents against methicillin-resistant Staphylococcus aureus isolates collected from 1991 to 2006.
BACKGROUND
Increasingly frequent reports of vancomycin treatment failures for serious methicillin-resistant Staphylococcus aureus (MRSA) infections provide impetus for comparative in vitro studies to assess the activity of newer antimicrobial agents against a range of MRSA isolates.


METHODS
A sample of 168 MRSA derived from a long-term MRSA collection was subjected to susceptibility testing to telavancin, daptomycin, linezolid, tigecycline and vancomycin by broth micro-dilution. Data were reviewed for sporadic occurrence of isolates with reduced susceptibility. Analyses were performed to test for temporal trends toward decreasing susceptibility and to compare susceptibility of isolates from different infection sites.


RESULTS
No MRSA isolate from any time period was resistant to test antibiotics. For daptomycin, linezolid and tigecycline, there were no susceptibility differences between the pre- and postclinical availability periods. All newer agents were active against MRSA isolates with minimum inhibitory concentrations (MICs) of vancomycin >1 mg/l, but there were significant correlations in susceptibility among several pairs of antibiotics.


CONCLUSIONS
Telavancin and other newer antistaphylococcal agents were fully active against MRSA from various infection sites including isolates with vancomycin MIC >1 mg/l.
Shams
Wael
W
James H. Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tenn., USA.
Walker
Elaine S
ES
Levy
Foster
F
Reynolds
Scott A
SA
Peterson
Shalena M
SM
Sarubbi
Felix A
FA
D000081:Acetamides / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology; D000069349:Linezolid; D000077427:Lipoglycopeptides; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D000078304:Tigecycline; D014640:Vancomycin / Q000494:pharmacology
D000081:Acetamides; D000617:Aminoglycosides; D000890:Anti-Infective Agents; D000077427:Lipoglycopeptides; D023303:Oxazolidinones; D014640:Vancomycin; D000078304:Tigecycline; D008911:Minocycline; D000069349:Linezolid; D017576:Daptomycin; C487637:telavancin