What has gene expression profiling taught us about glaucoma?
The availability in recent years of new cellular and animal models, as well as advances in genomic and related technologies, have made possible important advances in our understanding of the cellular and molecular events that mediate retinal ganglion cell dysfunction and death in glaucoma. In this review, we briefly summarize the methodology and results of a number of genome-wide expression studies that have been performed to study the retina and optic nerve head in glaucoma.
Yang
Zhiyong
Z
Department of Ophthalmology, Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zack
Donald J
DJ
D000818:Animals; D017209:Apoptosis; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D005901:Glaucoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000235:genetics* / Q000473:pathology; D012160:Retina / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology