A comparison between the efficacy of dydrogesterone and calcium plus vitamin D in improving women's general health.
OBJECTIVE
The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effect of dydrogesterone and calcium plus vitamin D on young women's general health.


METHODS
One hundred and eighty students studying at Shiraz University were recruited. Students completed the General Health Questionnaires (GHQ-28) prior to participation. They were then randomly assigned to take a tablet containing either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of their menstrual cycle for 2 consecutive cycles, and to complete the same questionnaires during both the intervention cycles.


RESULTS
The effects of dydrogesterone and calcium plus vitamin D on general health scores were similar during the first month of intervention (11.41 ± 4.28, 12.23 ± 3.76, respectively) (p>0.05) and both of them were more effective than placebo (16.69 ± 3.28) (p<0.05). However, dydrogesterone was more effective than calcium plus vitamin D and placebo during the second month of intervention (4.33 ± 2.69, 6.2 ± 3.55, 14.39 ± 3.45, respectively) (p<0.05). No significant differences between groups regarding drugs' side effects (p>0.05) were found.


CONCLUSIONS
Both dydrogesterone and calcium D were more effective than placebo in promoting women's general health. Dydrogesterone was, however, more efficient than calcium plus vitamin D.
College of Nursing & Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
M
M
Khajehei
K
K
Abdali
H R
HR
Tabatabaee
D000328:Adult; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D004394:Dydrogesterone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006304:Health Status; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology; D011372:Progestins / Q000008:administration & dosage* / Q000009:adverse effects; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage* / Q000009:adverse effects; D016387:Women's Health; D055815:Young Adult
D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D004338:Drug Combinations; D011372:Progestins; D014807:Vitamin D; D004394:Dydrogesterone