WITHDRAWN: Kidney injury molecule-1: a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury.
Ahead of Print article withdrawn by Publisher. Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated renal proximal tubular epithelial cells in damaged regions. Many studies have confirmed that KIM-1 is a specific marker of renal proximal tubular damage. Recently, more attention has been paid to its potential pathophysiological functions in renal injury or repair. A number of studies have illustrated the different functions of KIM-1 in various renal diseases, including its protective functions in acute kidney injury and damaging functions in chronic kidney disease. Although the exact functions of KIM-1 still remain unclear, some scientists speculate that KIM-1 may be a therapeutic target for kidney injury. In this review, some of the known features and functions of KIM-1 are highlighted.
Huo
Wenqian
W
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing - PR China.
Liu
Rongrong
R
Zhang
Keqin
K
Nie
Jin
J
Li
Qiansheng
Q
Jin
Fengshuo
F