Treatment of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia.
Progressive multifocal leukoencephalopathy is a neurological disease caused by the human polyoma virus JC virus and can present in patients with known immunodeficiencies. However, when associated with idiopathic CD4+ lymphocytopenia, management of patients can be quite challenging as these are two rare diseases with limited effective treatment options. In conjunction with the case report of a patient diagnosed with both conditions presented within this issue, a discussion of available treatment strategies is detailed.
The Methodist Hospital, Houston, TX 77030, USA. amila.patel@gmail.com
Amila
A
Patel
Julie
J
Patel
Judy
J
Ikwuagwu
D000998:Antiviral Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D000077404:Cidofovir; D003561:Cytarabine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D016207:Cytokines / Q000008:administration & dosage / Q000627:therapeutic use*; D003596:Cytosine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007577:JC Virus / Q000187:drug effects*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome
D000998:Antiviral Agents; D016207:Cytokines; D063065:Organophosphonates; D003561:Cytarabine; D003596:Cytosine; D000077404:Cidofovir