Plant products in the treatment and control of filariasis and other helminth infections and assay systems for antifilarial/anthelmintic activity.
Lymphatic filariasis, onchocerciasis, loaisis, and other helminth infections cause serious health problems especially in resource-limited tropical and subtropical developing countries of the world, and more than 2 billion people are infected with at least one helminth species. From times immemorial, man looked up to the plant kingdom in search of anthelmintics, antifilarials, and remedies for parasite-induced health problems. Although more than 50 % of drugs in modern medicine are derived from plants or leads from plants, a success story of plant-based anthelminthics or antifilarials is yet to be told. In the last 5 decades, more than 100 plant products were reported to be beneficial in the treatment or control of these parasitic infections but they could not be developed into viable drugs for a variety of reasons. This review focuses on the plant products reported to be useful in the control and treatment of human helminth infections with the main emphasis on filariasis and the in vitro and in vivo systems available for assaying anthelmintic activity.
Division of Parasitology, Central Drug Research Institute, CSIR, Lucknow, India. drpkmurthy@yahoo.com
Puvvada Kalpana
PK
Murthy
Sujith Kurian
SK
Joseph
Puvvada Sri Ramchandra
PS
Murthy
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001681:Biological Assay / Q000379:methods; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005368:Filariasis / Q000188:drug therapy* / Q000469:parasitology; D006373:Helminthiasis / Q000188:drug therapy* / Q000469:parasitology; D006376:Helminths / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*
D000871:Anthelmintics; D028321:Plant Preparations