MALDI imaging mass spectrometry--painting molecular pictures.
MALDI Imaging Mass Spectrometry is a molecular analytical technology capable of simultaneously measuring multiple analytes directly from intact tissue sections. Histological features within the sample can be correlated with molecular species without the need for target-specific reagents such as antibodies. Several studies have demonstrated the strength of the technology for uncovering new markers that correlate with disease severity as well as prognosis and therapeutic response. This review describes technological aspects of imaging mass spectrometry together with applications in cancer research.
Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.
Kristina
K
Schwamborn
Richard M
RM
Caprioli
D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000032:analysis; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation / Q000379:methods*; D009363:Neoplasm Proteins / Q000032:analysis; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D010455:Peptides / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation / Q000379:methods*
D008055:Lipids; D009363:Neoplasm Proteins; D010455:Peptides; D004364:Pharmaceutical Preparations