Actin crosslinkers: repairing the sense of touch.
Cells use actin bundles infused with myosin to exert contractile forces on the extracellular environment. This active tension is essential for cellular mechanosensation. Now, the role of actin crosslinkers in stabilizing and repairing the actin bundles is coming into clearer view.
Sun
Sean X
SX
Johns Hopkins University, Department of Mechanical Engineering, Institute for NanoBioTechnology, and Physical Science for Oncology Center, Baltimore, MD 21218, USA. ssun@jhu.edu
Walcott
Sam
S
D000199:Actins / Q000378:metabolism / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology*; D022001:Focal Adhesions / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D009218:Myosins / Q000378:metabolism*; D022502:Stress Fibers / Q000378:metabolism / Q000502:physiology*
D000199:Actins; D009218:Myosins