IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection.
An IL28B haplotype strongly determines the outcome of natural and interferon-α treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-α responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV.
Martin
Maureen P
MP
Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, NCI-Frederick, Frederick, Maryland, USA.
Qi
Ying
Y
Goedert
James J
JJ
Hussain
Shehnaz K
SK
Kirk
Gregory D
GD
Hoots
W Keith
WK
Buchbinder
Susan
S
Carrington
Mary
M
Thio
Chloe L
CL
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D016174:Hepacivirus; D006509:Hepatitis B / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006526:Hepatitis C; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics* / Q000276:immunology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D055815:Young Adult; D000095022:Interferon Lambda
D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda