Sleep-disordered breathing: in depression and schizophrenia.
Sleep disorders are becoming more prevalent. There is an overlap of symptoms related to obstructive sleep apnea syndrome (OSAS) and many psychiatric conditions. Complaints of excessive sleepiness, insomnia, cognitive dysfunction, and depressive symptoms can be related to both disease states. Obstructive sleep apnea syndrome is characterized by repetitive disruption of sleep by cessation of breathing and was first described in the 19th century by bedside observation during sleep. Physicians observed this cessation of breathing while the patient slept and postulated that these episodes were responsible for subsequent complaints of sleepiness. OSAS can coexist with major depressive disorder, exacerbate depressive symptoms, or be responsible for a large part of the symptom complex of depression. Additionally, in schizophrenia, sleep apnea may develop as a result of chronic neuroleptic treatment and its effect on gains in body weight, a major risk factor for the development of OSAS.It is important to recognize the signs and symptoms of sleep apnea, namely excessive daytime sleepiness, snoring, and witnessed apneas. Recognition of the existence of sleep apnea, prompt referral to a sleep specialist, and ultimately treatment of an underlying sleep disorder, such as OSAS, can ameliorate symptoms of psychiatric disease.
Dr. Jaffe is with the Department of Medicine, Division of Pulmonary, Critical Care Allergy, and Sleep, Thomas Jefferson University; and Drs. Markov and Doghramji are with the Department of Psychiatry and Human Behavior, Thomas Jefferson University; All are with the Sleep Disorders Center at Thomas Jefferson University, Philadelphia, Pennsylvania.
Fredric
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Jaffe
Dimitri
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Markov
Karl
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Doghramji