Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy.
A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels.
Chittaranjan National Cancer Institute, Department of Cancer Chemoprevention, Kolkata, West Bengal, India.
Somnath Singha
SS
Roy
Prosenjit
P
Ghosh
Ugir Hossain
UH
Sk
Pramita
P
Chakraborty
Jaydip
J
Biswas
Syamsundar
S
Mandal
Arin
A
Bhattacharjee
Sudin
S
Bhattacharya
D000818:Animals; D000975:Antioxidants; D003485:Cyanates; D004353:Drug Evaluation, Preclinical; D051379:Mice; D053644:Naphthalimides / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D010088:Oxidoreductases; D020011:Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D003485:Cyanates; D053644:Naphthalimides; D016566:Organoselenium Compounds; D020011:Protective Agents; D010088:Oxidoreductases