Inhibitors selective for HDAC6 in enzymes and cells.
Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Praveer K
PK
Gupta
Robert C
RC
Reid
Ligong
L
Liu
Andrew J
AJ
Lucke
Steve A
SA
Broomfield
Melanie R
MR
Andrews
Matthew J
MJ
Sweet
David P
DP
Fairlie
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D002460:Cell Line; D056284:Histone Deacetylase 1 / Q000187:drug effects; D000073864:Histone Deacetylase 6; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry*; D006655:Histone Deacetylases / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000201:enzymology; D051379:Mice; D011485:Protein Binding; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; C110550:HDAC1 protein, human; C433811:HDAC6 protein, human; D056284:Histone Deacetylase 1; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases