Mutual benefits of B-ALL and HLDA/HCDM HLDA 9th Barcelona 2010.
The B-cell panel of the ninth HLDA was applied in a multicentre fashion to cryopreserved cells from 46 patients with acute lymphoblastic leukemia. The reagents were aliquoted and shipped to volunteer participants from the French Groupe d'Etude Immunologique des Leucémies (GEIL). All samples were tested in flow cytometry, and the results collected as of the strength of labeling of the leukemic clone as negative, weak or strong. Among the 64 antibodies tested, the strongest and most frequent staining was observed for CD305 (LAIR), CD229 (Ly9), CD200 (OX-2) and, to a lesser extent, CD361 (EVI2b). Details of the observations, and information about the molecules tested are provided in the manuscript as well as a summary table.
Immunology, CHU de Brabois & Nancy Université, Allée du Morvan, Vandoeuvre les Nancy, France. faure@medecine.uhp-nancy.fr
Gilbert C
GC
Faure
Sophie
S
Amsellem
Christine
C
Arnoulet
Valérie
V
Bardet
Lydia
L
Campos
Marcelo
M
De Carvalho-Bittencourt
Adrienne
A
de Labarthe
Alice
A
Eischen
Jean
J
Feuillard
Chantal
C
Fossat
Francine Garnache
FG
Ottou
Estelle
E
Guérin
Julien
J
Guy
Hélène
H
Jouault
Emilienne
E
Kuhlein
Francis
F
Lacombe
Elodie
E
Lainey
Marc
M
Maynadié
Maria Elena
ME
Noguera
Mikael
M
Roussel
Françoise
F
Solly
Orianne Wagner
OW
Ballon
Marie C
MC
Béné
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D055815:Young Adult
D000911:Antibodies, Monoclonal; D015703:Antigens, CD