Acute kidney injury in the critically ill, morbidly obese patient: diagnostic and therapeutic challenges in a unique patient population.
The growing burden of morbid obesity (body mass index >40 kg/m²) on critical care resources translates to a significant incidence of acute kidney injury (AKI) in morbidly obese (MO), critically ill patients. This article examines the literature pertinent to AKI in critically ill MO patients. After a concise review of the available epidemiologic data regarding the incidence of acute renal injury in MO individuals, the authors review the limitations and available tools for estimation of renal function in the MO population (with emphasis on the critical illness). Also described are several specific types of renal injury previously described in this population that are applicable to the critical care setting. Lastly, the authors review some of the challenges and limitations in providing renal support to critically ill MO individuals, and identify potential areas for future research in this population.
Bucaloiu
Ion D
ID
Department of Nephrology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, USA. IDBUCALOIU@geisinger.edu
Perkins
Robert M
RM
DiFilippo
William
W
Yahya
Taher
T
Norfolk
Evan
E
D050110:Bariatric Surgery / Q000009:adverse effects; D003422:Critical Care; D016638:Critical Illness; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery; D017582:Renal Replacement Therapy; D012206:Rhabdomyolysis / Q000209:etiology; D012307:Risk Factors