Insulators: linking genome architecture to gene regulation.
Insulator elements have long been associated with a proposed domain boundary function, ensuring appropriate associations between regulatory elements and transcription units through the physical organisation of the genome into looped domains. Recent experiments in Drosophila have, however, highlighted a more direct involvement of insulators in transcriptional regulation.
White
Robert A H
RA
Department of Physiology, Development & Neuroscience, University of Cambridge Downing Street, Cambridge, CB2 3DY UK. rw108@cam.ac.uk