Overexpression of matrix metalloproteinase (MMP)-1 and -9 in central giant cell lesions of the jaws: implications for clinical behavior.
OBJECTIVE
The aim of this study was to investigate the relationship between the immunohistochemical expression of MMP-1 and MMP-9 with the clinical behavior of central giant cell lesions (CGCLs) of the jaws.


METHODS
Paraffin-embedded tissue from 30 aggressive and 12 nonaggressive CGCLs was assessed for the expression of MMP-1 and MMP-9 using immunohistochemistry.


RESULTS
Although cellular immunolocalization patterns of MMP-1 and MMP-9 were similar, mean values of expression estimation/SID scores of each protease were significantly higher in aggressive CGCLs in comparison with nonaggressive lesions. Moreover, linear regression analysis showed that there was a reasonably good correlation not only between the expression estimation but also among SID scores of the 2 proteolytic enzymes.


CONCLUSIONS
The findings of this study suggest a role for MMP-1 and MMP-9 in the resorptive activity of different cellular groups in CGCLs and indicate that differences in immunoreactivity of these 2 proteolytic enzymes may underlie the distinct clinical behavior.
Faculty of Dentistry, University of Antioquia, Medellín, Colombia. labinbio@odontologia.udea.edu.co
Sergio Iván
SI
Tobón-Arroyave
Sofía Milena
SM
Mideros-Simarra
Lina Marcela
LM
Castaño-Ramírez
Gloria Amparo
GA
Flórez-Moreno
Diana María
DM
Isaza-Guzmán
D000293:Adolescent; D000328:Adult; D002452:Cell Count; D048430:Cell Shape; D002648:Child; D002675:Child, Preschool; D003593:Cytoplasm / Q000201:enzymology / Q000648:ultrastructure; D018450:Disease Progression; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D015726:Giant Cells / Q000201:enzymology / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007571:Jaw Diseases / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008336:Mandibular Diseases / Q000201:enzymology / Q000473:pathology; D020781:Matrix Metalloproteinase 1 / Q000032:analysis*; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008439:Maxillary Diseases / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D010014:Osteolysis / Q000201:enzymology / Q000473:pathology; D012008:Recurrence; D017154:Stromal Cells / Q000201:enzymology / Q000473:pathology; D055815:Young Adult
D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1