Cleft lip and palate: series of unusual clinical cases.
Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face, corresponding to approximately 65% of all malformations of the craniofacial region.


OBJECTIVE
to describe unusual clinical cases of non-syndromic CL/P (CL/PNS), diagnosed in a reference service in Minas Gerais, Brazil, and correlate these alterations with possible risk factors.


METHODS
we carried out a retrospective study, between the years of 1992 and the 1st half of 2009, from medical records.


RESULTS
Among the 778 cases of CL/PNS diagnosed in the period of 17 years, 5 (0.64%) were unusual CL/PNS, and all patients were male. It was found that among the 5 patients, 2 had incomplete right cleft lip with incomplete cleft palate, 2 were affected by left incomplete cleft lip and incomplete cleft palate, and 1 had a cleft lip and palate associated with complete right cleft palate. Risk factors such as consanguinity, maternal smoking and alcohol consumption, medication usage during pregnancy, history of abortion and/or stillbirths and maternal diseases were not associated with unusual CL/PNS.


CONCLUSIONS
This study described 5 unusual cases of CL/PNS in a Brazilian population; no associations with the risk factors analyzed were seen. It also confirmed the unusualness of the prevalence of such alterations.
Paranaíba
Lívia Máris Ribeiro
LM
State University of Campinas - Unicamp.
Miranda
Roseli Teixeira de
RT
Martelli
Daniella Reis Barbosa
DR
Bonan
Paulo Rogério Ferreti
PR
Almeida
Hudson de
Hd
Orsi Júnior
Julian Miranda
JM
Martelli Júnior
Hercílio
H
D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D002971:Cleft Lip / Q000453:epidemiology / Q000209:etiology*; D002972:Cleft Palate / Q000453:epidemiology / Q000209:etiology*; D003241:Consanguinity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008046:Lip / Q000002:abnormalities; D008297:Male; D010159:Palate / Q000002:abnormalities; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects