Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands.
The coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the coordination mode of the ligands to be through the N of the imine and deprotonated phenol of the coumarin-derived ligand in solution. In addition, the more active complexes and their corresponding ligands were investigated in the presence of copper(II) in liquid and frozen solution by ESR spectroscopic methods. A series of secondary amine derivatives of the Schiff base ligands, were isolated with good solubility characteristics but showed little anti-Candida activity. However, cytotoxicity studies of the secondary amines, together with the copper complexes and their corresponding ligands, against human colon cancer and human breast cancer cells identified the chemotherapeutic potential of these new ligands.
Department of Science, Institute of Technology Tallaght, Dublin 24, Ireland.
Bernadette Sarah
BS
Creaven
Eszter
E
Czeglédi
Michael
M
Devereux
Éva Anna
ÉA
Enyedy
Agnieszka
A
Foltyn-Arfa Kia
Dariusz
D
Karcz
Andrew
A
Kellett
Siobhán
S
McClean
Nóra Veronika
NV
Nagy
Andy
A
Noble
Antal
A
Rockenbauer
Terézia
T
Szabó-Plánka
Maureen
M
Walsh
D000588:Amines / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011199:Potentiometry; D012545:Schiff Bases / Q000737:chemistry*; D012995:Solubility
D000588:Amines; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003374:Coumarins; D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D003300:Copper; C030123:coumarin