Liver failure due to antithyroid drugs: report of a case and literature review.
Hyperthyroidism is a common endocrine disorder affecting 2% of females and 0.5% of males worldwide and antithyroid drugs constitute the first line of treatment in the majority of cases. These agents may cause severe adverse effects and among them liver failure, although rare, is a potential lethal one. This case illustrates the sudden and abrupt deterioration of hepatic function due to antithyroid drug administration. This case along with a concise literature review is presented aiming to increase the awareness of endocrinologists of possible fatal complications from the everyday use of common agents such as antithyroid drugs.
First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece.
Sarantis
S
Livadas
Xenofon
X
Xyrafis
Frangiskos
F
Economou
Georgios
G
Boutzios
Maria
M
Christou
Aristea
A
Zerva
Athanasios
A
Karachalios
Helen
H
Palioura
Sotiria
S
Palimeri
Evanthia
E
Diamanti-Kandarakis
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000601:surgery; D017093:Liver Failure / Q000139:chemically induced*; D008713:Methimazole / Q000009:adverse effects*; D011441:Propylthiouracil / Q000009:adverse effects*; D013965:Thyroidectomy
D013956:Antithyroid Agents; D008713:Methimazole; D011441:Propylthiouracil