The flow synthesis of heterocycles for natural product and medicinal chemistry applications.
This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we discuss some of our results with a main focus on the synthesis of heterocyclic compounds which we use in various natural product and medicinal chemistry programmes.
Innovative Technology Centre for Advanced Chemical Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom. mb588@cam.ac.uk
Marcus
M
Baumann
Ian R
IR
Baxendale
Steven V
SV
Ley
D001386:Azides / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis; D002384:Catalysis; D002621:Chemistry / Q000295:instrumentation / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D001386:Azides; D001688:Biological Products; D006571:Heterocyclic Compounds