[Antidote against local anaesthetic intoxication: new use of lipid emulsion for intravenous administration].
Local anaesthetics are routinely used for several indications, but despite local administration their use may lead to systemic toxicity. The symptoms include numbness of the tongue, dizziness, tinnitus, visual disturbances, muscle spasms, convulsions, coma, and respiratory and cardiac arrest. Recently, an intravenous lipid emulsion was reported to act as a novel potential antidote for systemic toxicity due to local anaesthetics. We describe the application of this lipid emulsion in a 27-year-old patient with generalized seizures and coma due to local anaesthetic toxicity. She recovered quickly and was responsive again 10 minutes after the intravenous administration of the lipid emulsion.
ter Horst
Maarten
M
Erasmus MC, afd. Anesthesiologie, Rotterdam, the Netherlands. m.terhorst@erasmusmc.nl
Tjiang
Gilbert C H
GC
Luitwieler
Ronald L
RL
van Velzen
Chris
C
Stolker
Robert Jan
RJ
de Quelerij
Marcel
M
D000328:Adult; D000779:Anesthetics, Local / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D003128:Coma / Q000139:chemically induced* / Q000188:drug therapy; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D016896:Treatment Outcome
D000779:Anesthetics, Local; D005217:Fat Emulsions, Intravenous