[A study on the relationship between the expression of Bax gene products and prognosis in patients with human non-small cell lung cancer].
BACKGROUND
To explore the relationship between the expression of Bax gene and oncogenesis , development and prognosis of lung cancer.


METHODS
The expression level of Bax gene products was detected in 124 human non-small cell lung cancer by immunohistochemistry labelled-streptavidin-biotin methods.


RESULTS
The expressional level of Bax products in lung cancer tissues (53. 76 %) was significantly lower than that in the normal tissues adjacent to lung cancer (75. 51 %) and normal lung tissues (74. 97 %) ( P < 0. 01) . The expressional level of Bax products was closely related with P-TNM stage , the size of primary tumor and lymph node metastasis ( P < 0. 01 or P < 0. 05) ; but not to histological classification , cell differentiation and site of the cancer , and age , sex of the patients and smoking or not ( P > 0. 05) . The five-year survival rate in patients with high Bax expression was significantly higher than that in patients with low Bax expression ( P < 0. 01) .


CONCLUSIONS
Abnormal expression of Bax gene may play an important role in the oncogenesis , development and prognosis of lung cancer. Bax gene may be involved in the oncogenesis , development and metastasis of lung cancer.
Cancer Center , The First University Hospital , West China University of Medical Sciences , Chengdu , Sichuan 610041 , P. R. China.
L
L
Li
Q
Q
Zhou
H
H
Li
L
L
Liu
M
M
Qiu
D
D
Luo
C
C
Yi
S
S
Zhang
N
N
Cheng