Are anidulafungin or voriconazole released from polymethylmethacrylate in vitro?
BACKGROUND
Depot delivery of antimicrobial agents is used for treatment and prevention of bacterial orthopaedic infections; there is little information regarding newer antifungal agents and their potential use in polymethylmethacrylate (PMMA) depot delivery.


OBJECTIVE
We determined the percent of anidulafungin or voriconazole present after polymerization in PMMA beads loaded with anidulafungin or voriconazole, and we assessed elution of anidulafungin or voriconazole from beads loaded with anidulafungin or voriconazole.


METHODS
Beads containing 7.5% anidulafungin or voriconazole were pulverized and incubated in Kreb's ringer buffer for 48 hours; the buffer was assayed for anidulafungin or voriconazole concentration. The in vitro release of anidulafungin and voriconazole from PMMA beads loaded with 7.5% anidulafungin or voriconazole was determined in triplicate in a continuous flow chamber.


RESULTS
0.7% of anidulafungin and 5.6% of voriconazole loaded in the beads were detected after polymerization. No anidulafungin was detected in the elution studies. The mean peak voriconazole concentration in the elution studies was 0.9 μg/mL.


CONCLUSIONS
Anidulafungin may not be suitable for depot delivery in PMMA.
Rouse
Mark S
MS
Division of Infectious Disease, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Heijink
Andras
A
Steckelberg
James M
JM
Patel
Robin
R
D000077612:Anidulafungin; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D004343:Drug Implants; D054714:Echinocandins / Q000008:administration & dosage / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D011743:Pyrimidines / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage / Q000737:chemistry*; D065819:Voriconazole
D000935:Antifungal Agents; D004337:Drug Carriers; D004343:Drug Implants; D054714:Echinocandins; D011743:Pyrimidines; D014230:Triazoles; D019904:Polymethyl Methacrylate; D000077612:Anidulafungin; D065819:Voriconazole