Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure.
One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.
Wu
Xujun
X
Department of Chemical Engineering, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Jones
Matthew D
MD
Davidson
Matthew G
MG
Chaudhuri
Julian B
JB
Ellis
Marianne J
MJ
D002460:Cell Line; D006801:Humans; D006813:Humidity; D011098:Polyglactin 910 / Q000737:chemistry*; D012997:Solvents; D013501:Surface-Active Agents / Q000032:analysis*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
D012997:Solvents; D013501:Surface-Active Agents; D011098:Polyglactin 910