Dobutamine stress tagging and gradient-echo imaging for detection of coronary heart disease at 3 T.
OBJECTIVE
The purpose of this study was to evaluate the feasibility and diagnostic accuracy of a combined spoiled gradient-echo (sGRE) and tagged gradient-echo (SPAMM-GRE) protocol for detection of coronary artery disease (CAD) during high-dose dobutamine stress at 3 T.


METHODS
The study protocol was approved by the local ethics committee. For stress testing, a standard high-dose dobutamine protocol was employed. Image quality at the highest stress level and diagnostic accuracy of the sGRE and SPAMM-GRE sequences were compared. The final study population consisted of 37 patients.


RESULTS
The mean image quality score was 2.6±0.6 for the sGRE sequence and 2.4±0.6 for the SPAMM-GRE sequence (p>0.05). Sensitivity, specificity and diagnostic accuracy were 0.81, 0.86, 0.84 and 0.88, 0.86, 0.86 for the sGRE and SPAMM-GRE, respectively. In three cases with new wall motion abnormalities (WMAs), detected by sGRE and SPAMM-GRE, WMAs were detected at a lower stress level by tagging.


CONCLUSIONS
The combined sGRE and SPAMM-GRE high-dose dobutamine protocol at 3 T is feasible and delivers good diagnostic accuracy. Tagging increases the sensitivity of high-dose dobutamine stress testing for detection of CAD and may allow for detection of new WMAs at lower stress levels compared with sGRE alone.
Thomas
D
D
Department of Radiology, University of Bonn, Germany. daniel.thomas@ukb.uni-bonn.de
Meyer
C
C
Strach
K
K
Naehle
C P
CP
Mazraeh
J
J
Gampert
T
T
Schild
H H
HH
Sommer
T
T
D002316:Cardiotonic Agents; D017023:Coronary Angiography / Q000379:methods; D003327:Coronary Disease / Q000175:diagnosis*; D004280:Dobutamine; D025401:Echocardiography, Stress / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D002316:Cardiotonic Agents; D004280:Dobutamine