Mupirocin resistance in clinical isolates of staphylococci in a tertiary care centre in south India.
The present study was carried out to determine the rates of high-level and low-level mupirocin resistance in Staphylococcus spp. (MuH and MuL) in southern India. A prospective study was carried out on Staphylococcus spp. isolated for a period of three months in the microbiology laboratory of an 800-bedded tertiary care hospital. One hundred sixty-seven non-duplicate Staphylococcus spp. isolated from different specimens were tested for mupirocin susceptibility using 5 and 200 μg discs and by agar dilution. Rates of MuH were found to be two percent in methicillin-resistant Staphylococcus aureus (MRSA) and 28% in methicillin-resistant coagulase-negative Staphylococcus spp. (MRCoNS). MuL strains may be still treated with mupirocin, while MuH strains require other treatment options for eradication, making prior screening and differentiation important.
Department of Microbiology, PSG Institute of Medical Sciences & Research Centre, Peelameedu, Coimbatore, India. seema.oommen@gmail.com
S K
SK
Oommen
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B
Appalaraju
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K
Jinsha
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003030:Coagulase / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D006746:Hospital Bed Capacity, 500 and over; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D007194:India / Q000453:epidemiology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D003030:Coagulase; D016712:Mupirocin