Multiplexed detection of metabolites of narcotic drugs from a single latent fingermark.
An immunoassay based technique is used for the detection of psychoactive substances in the sweat deposited within fingermarks of a narcotic drug user. Magnetic particles functionalized with antimorphine and antibenzoylecgonine antibodies were used for the detection of a metabolite of heroin (morphine) and a metabolite of cocaine (benzoylecgonine), respectively. The drug metabolites were detected individually as well as simultaneously from a single fingermark. The images of the fingermarks obtained using brightfield and fluorescence microscopy were of high evidential quality with resolution to enable identification of an individual in addition to providing information on drug usage.
Pompi
P
Hazarika
Sue M
SM
Jickells
Kim
K
Wolff
David A
DA
Russell
D001681:Biological Assay / Q000379:methods*; D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D003878:Dermatoglyphics; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D018796:Immunoconjugates / Q000737:chemistry / Q000276:immunology; D008280:Magnetics; D009020:Morphine / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D009294:Narcotics / Q000032:analysis* / Q000276:immunology / Q000378:metabolism*; D015813:Substance Abuse Detection / Q000379:methods*; D013997:Time Factors
D018796:Immunoconjugates; D009294:Narcotics; C005618:benzoylecgonine; D009020:Morphine; D003042:Cocaine