Corynebacterium jeikeium pacemaker infection associated with antineutrophil cytoplasmic antibodies: a single positive blood culture could be sufficient for diagnosis.
Corynebacterium jeikeium, a member of the non-diphtheria corynebacteria, has been rarely reported as being responsible for cardiovascular-device infection. Here, we report what is believed to be the first case of C. jeikeium pacemaker infection associated with the presence of proteinase-3 antineutrophil cytoplasmic antibodies. The diagnosis was established based on the positivity of a single positive blood culture and led to pacemaker extraction. This observation highlights the difficulty in the diagnosis of cardiac-device infection in the presence of a single positive blood culture with a fastidious microorganism that could be considered as a contaminant. It also underscores the need for device extraction to ensure healing.
Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.|Faculté de Médecine, Université Paris Descartes, Paris, France.
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Bechara
Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
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Gousseff
Service de Médecine Interne, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
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Passeron
UMR S 872 - Equipe 12, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Centre de Recherche Biomédical des Cordeliers, Université Paris Descartes et Université Pierre et Marie Curie, Paris, France.|Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.|Faculté de Médecine, Université Paris Descartes, Paris, France.
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Podglajen
Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
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Day
Service de Médecine Interne, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.|Faculté de Médecine, Université Paris Descartes, Paris, France.
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Pouchot
Service de Cardiologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.|Faculté de Médecine, Université Paris Descartes, Paris, France.
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Lavergne
UMR S 872 - Equipe 12, Laboratoire de Recherche Moléculaire sur les Antibiotiques, Centre de Recherche Biomédical des Cordeliers, Université Paris Descartes et Université Pierre et Marie Curie, Paris, France.|Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.|Faculté de Médecine, Université Paris Descartes, Paris, France.
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Mainardi
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001769:Blood / Q000276:immunology / Q000382:microbiology*; D003352:Corynebacterium / Q000145:classification / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008297:Male; D053146:Myeloblastin / Q000276:immunology; D010138:Pacemaker, Artificial / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000382:microbiology
D019268:Antibodies, Antineutrophil Cytoplasmic; D053146:Myeloblastin