Toxicological analysis of 17 autopsy cases of hydrogen sulfide poisoning resulting from the inhalation of intentionally generated hydrogen sulfide gas.
Although many cases of fatal hydrogen sulfide poisoning have been reported, in most of these cases, it resulted from the accidental inhalation of hydrogen sulfide gas. In recent years, we experienced 17 autopsy cases of fatal hydrogen sulfide poisoning due to the inhalation of intentionally generated hydrogen sulfide gas. In this study, the concentrations of sulfide and thiosulfate in blood, urine, cerebrospinal fluid and pleural effusion were examined using GC/MS. The sulfide concentrations were blood: 0.11-31.84, urine: 0.01-1.28, cerebrospinal fluid: 0.02-1.59 and pleural effusion: 2.00-8.59 (μg/ml), while the thiosulfate concentrations were blood: 0-0.648, urine: 0-2.669, cerebrospinal fluid: 0.004-0.314 and pleural effusion: 0.019-0.140 (μmol/ml). In previous reports, the blood concentration of thiosulfate was said to be higher than that of sulfide in hydrogen sulfide poisoning cases, although the latter was higher than the former in 8 of the 14 cases examined in this study. These results are believed to be strongly influenced by the atmospheric concentration of hydrogen sulfide the victims were exposed to and the time interval between exposure and death.
Maebashi
Kyoko
K
Department of Forensic Medicine, The Jikei University School of Medicine 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan. maebashi@jikei.ac.jp
Iwadate
Kimiharu
K
Sakai
Kentaro
K
Takatsu
Akihiro
A
Fukui
Kenji
K
Aoyagi
Miwako
M
Ochiai
Eriko
E
Nagai
Tomonori
T
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000506:poisoning*; D002648:Child; D005260:Female; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D005740:Gases; D006801:Humans; D006862:Hydrogen Sulfide / Q000008:administration & dosage / Q000506:poisoning*; D008297:Male; D010996:Pleural Effusion; D013405:Suicide; D013440:Sulfides / Q000032:analysis*; D013885:Thiosulfates / Q000032:analysis*; D055815:Young Adult
D000393:Air Pollutants; D005740:Gases; D013440:Sulfides; D013885:Thiosulfates; D006862:Hydrogen Sulfide