European bone mineral density loci are also associated with BMD in East-Asian populations.
Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.
Styrkarsdottir
Unnur
U
deCODE Genetics, Reykjavik, Iceland. unnur.styrkarsdottir@decode.is
Halldorsson
Bjarni V
BV
Gudbjartsson
Daniel F
DF
Tang
Nelson L S
NL
Koh
Jung-Min
JM
Xiao
Su-mei
SM
Kwok
Timothy C Y
TC
Kim
Ghi Su
GS
Chan
Juliana C N
JC
Cherny
Stacey
S
Lee
Seung Hun
SH
Kwok
Anthony
A
Ho
Suzanne
S
Gretarsdottir
Solveig
S
Kostic
Jelena Pop
JP
Palsson
Stefan Th
ST
Sigurdsson
Gunnar
G
Sham
Pak C
PC
Kim
Beom-Jun
BJ
Kung
Annie W C
AW
Kim
Shin-Yoon
SY
Woo
Jean
J
Leung
Ping-C
PC
Kong
Augustine
A
Thorsteinsdottir
Unnur
U
Stefansson
Kari
K
D000368:Aged; D044466:Asian People / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D055106:Genome-Wide Association Study; D006615:Hip; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013131:Spine; D044465:White People / Q000235:genetics*