Serum levels of the adipokine fasting-induced adipose factor/angiopoietin-like protein 4 depend on renal function.
Fasting-induced adipose factor/angiopoietin-like protein 4 (FIAF/Angptl4) was recently introduced as a novel adipokine influencing glucose and lipid homeostasis. In the current study, we quantified circulating FIAF/Angtl4 levels in patients on chronic hemodialysis (CD) as compared to controls with a glomerular filtration rate above 50 ml/min. FIAF/Angptl4 was determined by ELISA in control (n=60) and CD (n=60) patients and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation, in both groups. Median serum FIAF/Angptl4 levels were more than 5-fold higher in CD patients (48.3 μg/l) as compared to control subjects (8.4 μg/l) (p<0.001). Furthermore, serum creatinine independently predicted FIAF/Angptl4 concentrations in multiple regression analyses in control subjects (p<0.01). In CD patients, C-reactive protein was independently and positively associated with circulating FIAF/Angptl4 (p<0.01). Taken together, we show that serum FIAF/Angptl4 levels are significantly increased in end-stage renal disease and independently associated with markers of renal function in control subjects.
University of Leipzig, Department of Internal Medicine III, Leipzig, Germany.
T
T
Baranowski
S
S
Kralisch
A
A
Bachmann
U
U
Lössner
J
J
Kratzsch
M
M
Blüher
M
M
Stumvoll
M
M
Fasshauer
D054392:Adipokines / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
C474772:ANGPTL4 protein, human; D054392:Adipokines; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins