COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136,000 coding mutations in almost 542,000 tumour samples; of the 18,490 genes documented, 4803 (26%) have one or more mutations. Full scientific literature curations are available on 83 major cancer genes and 49 fusion gene pairs (19 new cancer genes and 30 new fusion pairs this year) and this number is continually increasing. Key amongst these is TP53, now available through a collaboration with the IARC p53 database. In addition to data from the Cancer Genome Project (CGP) at the Sanger Institute, UK, and The Cancer Genome Atlas project (TCGA), large systematic screens are also now curated. Major website upgrades now make these data much more mineable, with many new selection filters and graphics. A Biomart is now available allowing more automated data mining and integration with other biological databases. Annotation of genomic features has become a significant focus; COSMIC has begun curating full-genome resequencing experiments, developing new web pages, export formats and graphics styles. With all genomic information recently updated to GRCh37, COSMIC integrates many diverse types of mutation information and is making much closer links with Ensembl and other data resources.
Forbes
Simon A
SA
Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA Cambridge, UK.
Bindal
Nidhi
N
Bamford
Sally
S
Cole
Charlotte
C
Kok
Chai Yin
CY
Beare
David
D
Jia
Mingming
M
Shepherd
Rebecca
R
Leung
Kenric
K
Menzies
Andrew
A
Teague
Jon W
JW
Campbell
Peter J
PJ
Stratton
Michael R
MR
Futreal
P Andrew
PA
D045744:Cell Line, Tumor; D057225:Data Mining; D030561:Databases, Nucleic Acid; D015894:Genome, Human; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D014584:User-Computer Interface