Paratesticular fibrous pseudotumor--an IgG4-related disorder?
Paratesticular fibrous pseudotumor (nodular periorchitis, inflammatory pseudotumor of the spermatic cord) is a rare, benign condition of unknown etiology characterized by solitary or multiple intrascrotal nodules composed of dense fibrous tissue with a variable, sometimes sparse inflammatory infiltrate. Based on certain similarities to other fibroinflammatory disorders characterized by infiltrates of IgG4-expressing plasma cells and recently subsumed under the heading of IgG4-mediated diseases, we investigated the plasma cell distribution and immunoglobulin isotypes in three cases of paratesticular fibrous and inflammatory pseudotumor. All three cases showed a high number of IgG4-positive plasma cells with an IgG4 to IgG ratio of 44-48%. This finding indicates that paratesticular fibrous pseudotumor might belong to the growing list of IgG4-related diseases, which by now includes such diverse entities as retroperitoneal fibrosis, sclerosing pancreatitis and cholangitis, Riedel's thyroiditis, or sclerosing sialadenitis.
Bösmüller
Hans
H
Department of Pathology, Krankenhaus Barmherzige Schwestern, Seilerstätte 4, 4020, Linz, Austria. hans-christian.boesmueller@bhs.at
von Weyhern
Claus Hann
CH
Adam
Patrick
P
Alibegovic
Vedat
V
Mikuz
Gregor
G
Fend
Falko
F
D000328:Adult; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D012598:Sclerosis / Q000276:immunology; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology
D007074:Immunoglobulin G