[The HPA axis in the pathogenesis of chronic fatigue syndrome].
Chronic fatigue syndrome (CFS) is a clinical syndrome characterized by profound disabling chronic fatigue associated with a wide array of other physical symptoms. Its etiology is currently unknown. Among the various hypotheses, considerable interest has been placed in the hypothalamus-pituitary-adrenal axis as a possible target of the pathogenesis of CFS. This article reviews the available scientific evidence about a role of hypothalamic-pituitary-adrenal axis in the pathogenesis of chronic fatigue syndrome.
Ursini
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Dipartimento di Medicina Interna Unità di Medicina Sperimentale e Clinica dell'Università di Catanzaro Magna Graecia, Catanzaro, Italia. francesco.ursini@yahoo.it
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Gagliardi
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D015673:Fatigue Syndrome, Chronic / Q000209:etiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology