CD117 expression in gammopathies is associated with an altered maturation of the myeloid and lymphoid hematopoietic cell compartments and favorable disease features.
Aberrant CD117 expression is associated with a favorable outcome in multiple myeloma. We analyzed 106 patients with symptomatic multiple myeloma (n=50), smoldering multiple myeloma (n=38) and monoclonal gammopathy of undetermined significance (n=18) to elucidate biological features of CD117(+) versus CD117(-) monoclonal gammopathies. CD117(+) (mono)clonal plasma cells were detected in 30% symptomatic multiple myeloma, 45% smoldering multiple myeloma and 72% monoclonal gammopathy of undetermined significance patients. CD117 expression was associated with higher percentages of normal bone marrow plasma cells, CD117(+) myeloid precursors and CD38(+) B lymphocytes in all monoclonal gammopathies. Conversely, the number of bone marrow CD34(+) myeloid cells and peripheral blood neutrophils was reduced among CD117(+) multiple myeloma but not monoclonal gammopathy of undetermined significance patients. CD117 expression by (mono)clonal plasma cells is associated with uniquely altered patterns of production of hematopoietic bone marrow cells with decreased peripheral blood neutrophil counts and persistence of normal residual bone marrow plasma cells.
Department of Medicine, Services of Cytometry and Hematology and Cancer Research Center (CIC, IBMCC USAL-CSIC), University of Salamanca and University Hospital of Salamanca, Salamanca, Spain.
Martin
M
Schmidt-Hieber
Martin
M
Pérez-Andrés
Bruno
B
Paiva
Juan
J
Flores-Montero
Jose J
JJ
Perez
Norma C
NC
Gutierrez
Maria-Belen
MB
Vidriales
Sergio
S
Matarraz
Jesus F
JF
San Miguel
Alberto
A
Orfao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006413:Hematopoietic System / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D022423:Myeloid Cells / Q000378:metabolism / Q000473:pathology*; D010265:Paraproteinemias / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011003:Ploidies; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit