LINGO1 rs9652490 variant in Parkinson disease patients.
Essential tremor (ET) has been hypothesized to be a risk factor for the development of Parkinson disease (PD). Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility. To evaluate whether the same variant is associated also with PD susceptibility, we investigated the association between the LINGO1 rs9652490 variant and PD phenotype in Caucasian and Chinese PD subjects. We found no significant differences in genotypic and allele distribution between patients and control subjects (χ(2)=1.931, p=0.381 for genotypic distribution; χ(2)=0.001, p=0.973 for allele distribution), suggesting this variant is not associated with PD.
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yi
Y
Guo
Joseph
J
Jankovic
Zhi
Z
Song
Huarong
H
Yang
Wen
W
Zheng
Weidong
W
Le
Xiangqi
X
Tang
Xiong
X
Deng
Yan
Y
Yang
Sheng
S
Deng
Ziqiang
Z
Luo
Hao
H
Deng
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D010641:Phenotype; D044465:White People / Q000235:genetics*
C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins