An update on pathobiologic roles of anti-glycan antibodies in Guillain-Barré syndrome.
Anti-glycan antibodies directed against gangliosides are now considered the major immune effectors that induce damage to intact nerve fibers in some variants of the monophasic neuropathic disorders that comprise Guillain-Barré syndrome. Recent experimental studies elucidating the complexity of anti-glycan antibody-mediated pathobiologic effects on intact and injured nerves undergoing repair are discussed.
Department of Neurology, University of Texas Medical School at Houston 6431 Fannin Street, Houston, TX 77030 USA.
Kazim A
KA
Sheikh
Gang
G
Zhang