Propofol as a bridge to extubation for high-risk children with congenital cardiac disease.
BACKGROUND
Children with congenital cardiac defects may have associated chromosomal anomalies, airway compromise, and/or pulmonary hypertension, which can pose challenges to adequate sedation, weaning from mechanical ventilation, and successful extubation. Propofol, with its unique properties, may be used as a bridge to extubation in certain cardiac populations.


METHODS
We retrospectively reviewed 0-17-year-old patients admitted to the Cardiac Intensive Care Unit between January, 2007 and September, 2008, who required mechanical ventilation and received a continuous infusion of propofol as a bridge to extubation. Medical charts were reviewed for demographics, associated comorbidities, as well as additional sedation medications and haemodynamic trends including vital signs and vasopressor support during the peri-infusion period. Successful extubation was defined as no re-intubation required for respiratory failure within 48 hours. Outcomes measured were successful extubation, evidence for propofol infusion syndrome, haemodynamic stability, and fluid and inotropic requirements.


RESULTS
We included 11 patients for a total of 12 episodes. Propofol dose ranged from 0.4 to 5.6 milligram per kilogram per hour with an average infusion duration of 7 hours. All patients were successfully extubated, and none demonstrated worsening metabolic acidosis suggestive of the propofol infusion syndrome. All patients remained haemodynamically stable during the infusion with average heart rates and blood pressures remaining within age-appropriate ranges. One patient received additional fluid but no increase in vasopressors was needed.


CONCLUSIONS
This study suggests that propofol infusions may allow for successful extubation in a certain population of children with congenital cardiac disease. Further studies are required to confirm whether propofol is an efficient and safe alternative in this setting.
Department of Pediatrics, Section of Pediatric Critical Care, The Children's Hospital, University of Colorado at Denver, School of Medicine, Aurora, Colorado, USA.
Sarena N
SN
Teng
Jon
J
Kaufman
Angela S
AS
Czaja
Robert H
RH
Friesen
Eduardo M
EM
da Cruz
D000293:Adolescent; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D020878:Device Removal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008297:Male; D011182:Postoperative Care / Q000379:methods*; D011379:Prognosis; D015742:Propofol / Q000008:administration & dosage*; D012189:Retrospective Studies; D012307:Risk Factors; D015300:Ventilator Weaning / Q000379:methods*
D018686:Anesthetics, Intravenous; D015742:Propofol