Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman.
An efficient method for an iron catalyzed oxidative indolation and methoxyphenylation of N-protected tetrahydroisoquinolines and isochroman is described including subsequent facile deprotection.
Institute for Applied Synthetic Chemistry, Technical University of Vienna, 1060 Vienna, Austria.
Michael
M
Ghobrial
Karin
K
Harhammer
Marko D
MD
Mihovilovic
Michael
M
Schnürch
D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D002839:Chromans; D008024:Ligands; D012997:Solvents; D044005:Tetrahydroisoquinolines; D007501:Iron