Paradoxical contractile properties in the knee extensors of HIV-infected men treated with antiretroviral therapy.
We assessed contractile properties in the knee extensors of 18 men with the human immunodeficiency virus (HIV+) being treated with antiretroviral therapy (ART), and 9 healthy controls matched for age and body mass index. We found significant, divergent differences between groups with regard to force relaxation. Half-times of twitch relaxation were shorter (62.6 ± 5.4 ms vs. 48.9 ± 3.0 ms; p = 0.045) and maximum rates of torque relaxation were slower (0.47% ± 0.04%(s-)1 vs. 1.32% ± 0.10%(s-)1; p < 0.001) in HIV+ individuals. These preliminary findings suggest potential intramuscular impairments in HIV+ individuals on ART, perhaps because of interactions between calcium handling and mitochondrial dysfunction.
Russ
David W
DW
School of Physical Therapy, Ohio University, Athens, OH 45701, USA. russd@ohio.edu
Scott
Wayne B
WB
Oursler
Krisann K
KK
King
Jenna Salter
JS
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007719:Knee Joint / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D019415:Torque
D019380:Anti-HIV Agents; D002118:Calcium