Iron pill-induced tumefactive mucosal injury of the hypopharynx.
Iron pill-induced mucosal injury of the airways with massive necrosis and stricture of the lower airways is known to occur, but symptomatic injury of the hypopharyngeal mucosa secondary to therapeutic oral iron ingestion has not been described. We report iron-sulfate-induced mucosal injury of the hypopharynx in a patient receiving therapeutic oral iron supplementation. The patient presented with dysphagia when swallowing pills, but not when eating or drinking. Imaging studies and clinical examination revealed an ulcerated and protuberant hypopharyngeal mass. Histology showed mucosal ulceration with deposits of extracellular crystalline iron particles. The histologic changes were identical to those seen in patients with "iron pill" gastritis.
Cimino-Mathews
Ashley
A
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Broman
Jerry H
JH
Westra
William H
WH
Illei
Peter B
PB
D000284:Administration, Oral; D000369:Aged, 80 and over; D001706:Biopsy; D003680:Deglutition Disorders / Q000503:physiopathology; D004724:Endoscopy; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D006397:Hematinics / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007013:Hypopharynx / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D013607:Tablets; D014057:Tomography, X-Ray Computed; D014456:Ulcer / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology
D005296:Ferrous Compounds; D006397:Hematinics; D013607:Tablets; C020748:ferrous sulfate