Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada.
OBJECTIVE
To determine whether certain maternal characteristics and obstetric complications are associated with increased risk of autism spectrum disorders (ASD) in children.


METHODS
Provincial delivery records identified the cohort of 218 890 singleton live births in Alberta, Canada,between January 1, 1998, and December 31, 2004. These were followed-up for ASD via ICD-9 diagnostic codes assigned by physician billing until March 31, 2008. Maternal and obstetric risk factors were also extracted from PDR.


RESULTS
Prevalence and incidence of ASD in Alberta are in line with those reported elsewhere and suggest recent increases in rate of diagnosis and/or incidence. Boys have 5-fold higher prevalence than girls. The peak age of diagnosis occurs at age 3 years. Relative risk modelling indicates that the risk of ASD is elevated among children of older mothers and those who experience specific pregnancy and birth complications.


CONCLUSIONS
Certain maternal characteristics and obstetric complications are associated with ASD in children. We identified lower rates of ASD and later age at diagnosis among children of Aboriginal mothers that requires further research.
Community and Occupational Medicine Program, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. igor.burstyn@drexel.edu
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Burstyn
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Sithole
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Zwaigenbaum
D000328:Adult; D017677:Age Distribution; D000416:Alberta / Q000453:epidemiology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000453:epidemiology* / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D008499:Medical Records; D007744:Obstetric Labor Complications; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D055815:Young Adult