The herpes simplex virus type 1 infected cell protein 22.
As one of the immediate-early (IE) proteins of herpes simplex virus type 1 (HSV-1), ICP22 is a multifunctional viral regulator that localizes in the nucleus of infected cells. It is required in experimental animal systems and some nonhuman cell lines, but not in Vero or HEp-2 cells. ICP22 is extensively phosphorylated by viral and cellular kinases and nucleotidylylated by casein kinase II. It has been shown to be required for efficient expression of early (E) genes and a subset of late (L) genes. ICP22, in conjunction with the UL13 kinase, mediates the phosphorylation of RNA polymerase II. Both ICP22 and UL13 are required for the activation of cdc2, the degradation of cyclins A and B and the acquisition of a new cdc2 partner, the UL42 DNA polymerase processivity factor. The cdc2-UL42 complex mediates postranscriptional modification of topoisomerase IIα in an ICP22-dependent manner to promote L gene expression. In addition, ICP22 interacts with cdk9 in a Us3 kinase dependent fashion to phosphorylate RNA polymerase II.
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Fu-sen
FS
Lin
Qiong
Q
Ding
Hong
H
Guo
Alan C
AC
Zheng
D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002460:Cell Line; D019925:Cyclin A / Q000378:metabolism; D019926:Cyclin B / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D012319:RNA Polymerase II / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D000951:Antigens, Neoplasm; D019925:Cyclin A; D019926:Cyclin B; D004268:DNA-Binding Proteins; C057294:ICP22 protein, human herpesvirus 1; D017874:Immediate-Early Proteins; D009711:Nucleotides; D014764:Viral Proteins; D011494:Protein Kinases; C082380:UL13 protein, Simplexvirus; D016203:CDC2 Protein Kinase; D012319:RNA Polymerase II; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C043417:DNA polymerase, Simplexvirus; D004250:DNA Topoisomerases, Type II