Sperm toxicity of "nonspermicidal" lubricant and ultrasound gels used in reproductive medicine.
Three commercial, nonspermicidal gels used in fertility practice were found to be toxic to sperm in a 24-hr sperm survival assay; these included Felis, Replens, and Aquasonic Gel, which is used for transvaginal ultrasound during ovulation monitoring. In contrast, Pre-Seed did not cause any sperm toxicity, suggesting its appropriate use by patients who are trying to conceive, as well as clinicians during fertility procedures.
Foundation FABER, Lausanne, Switzerland.
Josefina
J
Vargas
Michel
M
Crausaz
Alfred
A
Senn
Marc
M
Germond
D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005782:Gels / Q000494:pharmacology*; D006801:Humans; D054327:Lubricants / Q000009:adverse effects*; D008297:Male; D009930:Organic Chemicals / Q000494:pharmacology; D018456:Reproductive Medicine / Q000379:methods*; D055101:Semen Analysis; D013089:Spermatocidal Agents / Q000494:pharmacology; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods*
C071627:Aquasonic; D005782:Gels; D054327:Lubricants; D009930:Organic Chemicals; D013089:Spermatocidal Agents