Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland.
A Klebsiella pneumoniae epidemic strain that coproduced carbapenemase KPC-2 (K. pneumoniae carbapenemase 2) and 16S rRNA methylase ArmA has emerged in Poland. Four nonduplicate isolates from patients in a hospital in Warsaw, Poland, were found to carry the bla(KPC-2) and armA genes on ca. 50-kb and 90-kb plasmids, respectively. Tn4401 with a 100-bp deletion in the variable region was detected in all the isolates. XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.
Zacharczuk
Katarzyna
K
Department of Bacteriology, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.
Piekarska
Katarzyna
K
Szych
Jolanta
J
Zawidzka
Elwira
E
Sulikowska
Agnieszka
A
Wardak
Sebastian
S
Jagielski
Marek
M
Gierczynski
Rafal
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D006595:Hexosamines / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology*; D008780:Methyltransferases / Q000378:metabolism*; D011044:Poland; D012336:RNA, Ribosomal, 16S / Q000378:metabolism*; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D006595:Hexosamines; D012336:RNA, Ribosomal, 16S; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; C007265:2-deoxystreptamine