In vivo assessment of prenatal developmental toxicity in rodents.
This unit presents two basic protocols for testing prenatal developmental toxicity in rodents. The standard protocol for assessing prenatal developmental toxicity, often referred to as a Segment II study, describes the methods used for performing cesarean sections and examining cesarean-delivered fetuses for external, skeletal, and visceral alterations. The protocol for the Chernoff/Kavlock assay, a developmental toxicity screen, describes methods for examining parturition, and postnatal growth and viability of prenatally exposed litters.
Narotsky
Michael G
MG
U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Kavlock
Robert J
RJ
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006128:Growth / Q000187:drug effects*; D051379:Mice; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D018675:Toxicity Tests