Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1.
Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.
Lee
Sujin
S
College of Pharmacy, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
Maharjan
Sony
S
Kim
Kyeojin
K
Kim
Nam-Jung
NJ
Choi
Hyun-Jung
HJ
Kwon
Young-Guen
YG
Suh
Young-Ger
YG
D017209:Apoptosis / Q000187:drug effects*; D001808:Blood Vessels / Q000293:injuries / Q000473:pathology; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000187:drug effects / Q000473:pathology; D036145:Ginsenosides / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D036145:Ginsenosides; C472077:ginsenoside Rk1; D002784:Cholesterol