CSLEX (Sialyl Lewis X) is a useful tumor marker for monitoring of breast cancer patients.
BACKGROUND
CSLEX is a type II carbohydrate antigen that interacts with the CSLEX-1 monoclonal antibody. CSLEX in combination with carbohydrate antigen 15-3 may be more useful than Carcinoembryonic Antigen with carbohydrate antigen 15-3 as tumor markers for monitoring of breast cancer.


METHODS
The serum levels of tumor markers, including CSLEX, were measured in 480 consecutive breast cancer patients with or without metastasis who visited the outpatient clinic of the Division of Breast and Endocrine Surgery, Shinshu University Hospital, between April 2007 and September 2007.


RESULTS
Serum levels of each of the tumor markers correlated significantly with the status of metastasis (P < 0.01). Combinations of Carcinoembryonic Antigen and carbohydrate antigen 15-3, Carcinoembryonic Antigen and Nation Cancer Center-Stomach-439, Carcinoembryonic Antigen and CSLEX, carbohydrate antigen 15-3 and Nation Cancer Center-Stomach-439, and carbohydrate antigen 15-3 and CSLEX levels also correlated significantly with the status of metastasis (P < 0.01). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were almost the same for CSLEX and Nation Cancer Center-Stomach-439, which are both type II carbohydrate antigens. The cutoff indexes of serum CSLEX and Nation Cancer Center-Stomach-439 for detection of breast cancer metastasis were 38.8 ± 52.7-fold and 22.1 ± 27.8-fold, respectively (P = 0.16).


CONCLUSIONS
These data suggest that the diagnostic values of CSLEX and Nation Cancer Center-Stomach-439 are similar in single or combined use. However, the cutoff index of serum CSLEX tended to be higher than that of Nation Cancer Center-Stomach-439, which may make CSLEX more useful for detection of breast cancer metastasis.
Department of Breast Surgery, Tokyo Medical University, Ami Inashiki, Ibaraki 300-0395, Japan.
Tomoyuki
T
Fujita
Koichi
K
Murayama
Toru
T
Hanamura
Toshihiro
T
Okada
Tokiko
T
Ito
Michihiko
M
Harada
Akira
A
Komatsu
Hiroshi
H
Koyama
Toshiharu
T
Kanai
Kazuma
K
Maeno
Yasuhiro
Y
Mochizuki
Yoshihisa
Y
Hama
Ken-Ichi
K
Ito
Jun
J
Amano
Minoru
M
Fujimori
D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009844:Oligosaccharides / Q000097:blood*; D011379:Prognosis; D012372:ROC Curve; D012680:Sensitivity and Specificity; D000080506:Sialyl Lewis X Antigen
D014408:Biomarkers, Tumor; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen