Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy.
For the first time we present data showing that metabolic targeted therapy with dichloroacetate (DCA) may improve the outcome of photodynamic therapy. This treatment modality can be easily introduced into clinical practice guidelines.
Kwitniewski
Mateusz
M
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, 0310, Norway. kwitniewski@gumed.edu.pl
Moan
Johan
J
Juzeniene
Asta
A
D045744:Cell Line, Tumor; D003999:Dichloroacetic Acid / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D008027:Light; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use / Q000633:toxicity; D010795:Phthalic Acids / Q000627:therapeutic use / Q000633:toxicity
D017319:Photosensitizing Agents; D010795:Phthalic Acids; C102688:5-aminoisophthalic acid; D003999:Dichloroacetic Acid