Association of vitamin D receptor Taq I polymorphism and susceptibility to oral squamous cell carcinoma.
BACKGROUND
It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis.


METHODS
The distribution of VDR Taq I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RFLP) and compared with that of 87 healthy controls.


RESULTS
There was a significant difference in the distribution of VDR Taq I genotypes between OSCC patients and healthy controls. Patients with the VDR Tt genotype were found to be at significantly higher risk for OSCC than those with other genotypes (p=0.036). In particular, female OSCC patients were at higher risk (p<0.001) for oral cancer.


CONCLUSIONS
These results suggest that the VDR Taq I polymorphism may be associated with susceptibility to OSCC. Female predilection of the OSCC risk in association with VDR gene polymorphism should also be investigated.
Bektas-Kayhan
Kivanç
K
İstanbul Üniversitesi Dişhekimliği Fakültesi, Ağız,Diş, Çene Hastalıkları Bilim Dalı 6.kat, 34093 Çapa/İstanbul, Turkey. bektaskk@istanbul.edu.tr
Unür
Meral
M
Yaylim-Eraltan
Ilhan
I
Ergen
H Arzu
HA
Toptas
Bahar
B
Hafiz
Günter
G
Karadeniz
Ahmet
A
Isbir
Turgay
T
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
D018167:Receptors, Calcitriol