Role of glucocorticoid-induced leucine zipper (GILZ) expression by dendritic cells in tolerance induction.
Dendritic cells (DCs) play a crucial role in T cell allorecognition in the context of organ transplantation and allogeneic hematopoietic stem cell transplantation (allo-HSCT). This DC function is believed to be directly involved in allo-HSCT morbidity and mortality. DC functions range from immunoaggressive responses to the promotion of tolerance, reflecting functional plasticity. This unique characteristic offers a rationale to propose generation of tolerogenic DCs as a therapeutic tool for graft-versus-host disease (GVHD). The accumulated preclinical findings support the concept that glucocorticoid-induced leucine zipper (GLIZ) expression redirects mature DC function toward a tolerogenic mode, driving differentiation of antigen-specific regulatory T cells. Taking into account the unique role of DCs within the allo-HSCT context, novel preventive and curative therapeutics for GVHD might be based on the selective induction of GILZ expression in vivo.
INSERM U996, Université Paris-Sud 11 and Hôpital Antoine Béclère, Assistance Publique Hôpitaux de Paris, Clamart, France. roman.krzysiek@abc.aphp.fr
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D003713:Dendritic Cells / Q000276:immunology*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D014157:Transcription Factors / Q000502:physiology*
C404226:TSC22D3 protein, human; D014157:Transcription Factors