Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle.
Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
Department of Otolaryngology, Chi Mei Medical Center, Liouying, Tainan 717, Taiwan.
Ching-Yi
CY
Yiu
Shih-Ying
SY
Chen
Li-Kwan
LK
Chang
Ya-Fang
YF
Chiu
Tsuey-Pin
TP
Lin
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002460:Cell Line; D017781:Genes, Immediate-Early; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics; D014771:Virion / Q000187:drug effects / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects*
D000975:Antioxidants; D013267:Stilbenes; D014764:Viral Proteins; D000077185:Resveratrol