IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling.
helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein β (C/EPBβ) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor γ (PPARγ). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation.
Lee
Suk Jun
SJ
College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Lee
Eun Ju
EJ
Kim
Sang-Hoon
SH
Choi
Inho
I
Lee
Dong-Mok
DM
Lee
Hyun-Jeong
HJ
Yoon
Duhak
D
Chun
Taehoon
T
D017667:Adipocytes / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism*; D054338:Cell Transdifferentiation; D020381:Interleukin-17 / Q000378:metabolism*; D051379:Mice; D032446:Myoblasts / Q000187:drug effects / Q000502:physiology*; D047495:PPAR gamma / Q000096:biosynthesis*; D015398:Signal Transduction
D022762:CCAAT-Enhancer-Binding Proteins; D020381:Interleukin-17; D047495:PPAR gamma