MiRonTop: mining microRNAs targets across large scale gene expression studies.
CONCLUSIONS
Current challenges in microRNA (miRNA) research are to improve the identification of in vivo mRNA targets and clarify the complex interplay existing between a specific miRNA and multiple biological networks. MiRonTop is an online java web tool that integrates DNA microarrays or high-throughput sequencing data to identify the potential implication of miRNAs on a specific biological system. It allows a rapid characterization of the most pertinent mRNA targets according to several existing miRNA target prediction approaches. It also provides useful representations of the enrichment scores according to the position of the target site along the 3'-UTR, where the contribution of the sites located in the vicinity of the stop codon and of the polyA tail can be clearly highlighted. It provides different graphs of miRNA enrichment associated with up- or down-regulated transcripts and different summary tables about selections of mRNA targets and their functional annotations by Gene Ontology.


BACKGROUND
http://www.microarray.fr:8080/miRonTop/index.
Le Brigand
Kevin
K
Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis, Nice, France.
Robbe-Sermesant
Karine
K
Mari
Bernard
B
Barbry
Pascal
P
D020413:3' Untranslated Regions; D057225:Data Mining; D015870:Gene Expression; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D020407:Internet; D035683:MicroRNAs / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000378:metabolism*; D012984:Software
D020413:3' Untranslated Regions; D035683:MicroRNAs; D012333:RNA, Messenger