[Aspects of atherosclerosis and metabolic syndrome in lupus erythematosus].
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting mainly young women. In last decades premature atherosclerosis has been identified as an important cause of mortality due to SLE related risk factors (inflammation and treatment) and metabolic syndrome (MS). MS is a group of risk factors, originating from an abnormal metabolism, with an increased risk for developing atherosclerotic cardiovascular disease. The prevalence of MS varies from 5,5-55,4% in the general population and has been observed up to 40% in SLE, associated with advanced age, low socioeconomic status, lack of exercise, use of high doses of prednisone and disease activity. Treatment should include identification and modification of these risk factors.
Disciplina de Reumatologia, Hospital das clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo-SP, Brasil.
Iana Sousa
IS
Nascimento
Caio Robledo D'Angioli Costa
CR
Quaio
Nailú Angélica
NA
Sinicato
Simone
S
Appenzeller
Jozélio Freire
JF
de Carvalho
D050197:Atherosclerosis / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D024821:Metabolic Syndrome / Q000209:etiology*