Mupirocin resistance in clinical isolates of staphylococci in a tertiary care centre in south India.
The present study was carried out to determine the rates of high-level and low-level mupirocin resistance in Staphylococcus spp. (MuH and MuL) in southern India. A prospective study was carried out on Staphylococcus spp. isolated for a period of three months in the microbiology laboratory of an 800-bedded tertiary care hospital. One hundred sixty-seven non-duplicate Staphylococcus spp. isolated from different specimens were tested for mupirocin susceptibility using 5 and 200 μg discs and by agar dilution. Rates of MuH were found to be two percent in methicillin-resistant Staphylococcus aureus (MRSA) and 28% in methicillin-resistant coagulase-negative Staphylococcus spp. (MRCoNS). MuL strains may be still treated with mupirocin, while MuH strains require other treatment options for eradication, making prior screening and differentiation important.
Oommen
S K
SK
Department of Microbiology, PSG Institute of Medical Sciences & Research Centre, Peelameedu, Coimbatore, India. seema.oommen@gmail.com
Appalaraju
B
B
Jinsha
K
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003030:Coagulase / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D006746:Hospital Bed Capacity, 500 and over; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D007194:India / Q000453:epidemiology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D003030:Coagulase; D016712:Mupirocin