European bone mineral density loci are also associated with BMD in East-Asian populations.
Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.
deCODE Genetics, Reykjavik, Iceland. unnur.styrkarsdottir@decode.is
Unnur
U
Styrkarsdottir
Bjarni V
BV
Halldorsson
Daniel F
DF
Gudbjartsson
Nelson L S
NL
Tang
Jung-Min
JM
Koh
Su-mei
SM
Xiao
Timothy C Y
TC
Kwok
Ghi Su
GS
Kim
Juliana C N
JC
Chan
Stacey
S
Cherny
Seung Hun
SH
Lee
Anthony
A
Kwok
Suzanne
S
Ho
Solveig
S
Gretarsdottir
Jelena Pop
JP
Kostic
Stefan Th
ST
Palsson
Gunnar
G
Sigurdsson
Pak C
PC
Sham
Beom-Jun
BJ
Kim
Annie W C
AW
Kung
Shin-Yoon
SY
Kim
Jean
J
Woo
Ping-C
PC
Leung
Augustine
A
Kong
Unnur
U
Thorsteinsdottir
Kari
K
Stefansson
D000368:Aged; D044466:Asian People / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D055106:Genome-Wide Association Study; D006615:Hip; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013131:Spine; D044465:White People / Q000235:genetics*