Primary bilateral adrenal diffuse large B-cell lymphoma demonstrating adrenal failure.
Primary adrenal lymphoma (PAL) is extremely rare although involvement of malignant lymphoma into adrenals is common. We report a case of a 58-year-old man with bilateral PAL who demonstrated adrenal insufficiency. Primary large B-cell lymphoma was proven by a computed tomography-guided needle biopsy of the adrenal tumor. Although a complete remission was once achieved by combination chemotherapy plus rituximab, a recurrence occurred with brain metastasis leading to his death. We concluded that PAL should be considered as a possible cause of bilateral adrenal incidentalomas with progressive adrenal insufficiency.
Horiguchi
Kazuhiko
K
Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi.
Hashimoto
Koshi
K
Hashizume
Masayuki
M
Masuo
Takashige
T
Suto
Mariko
M
Okajo
Jun
J
Handa
Hiroshi
H
Kaneko
Yoriaki
Y
Yokoo
Hideaki
H
Sasaki
Atsushi
A
Okada
Shuichi
S
Yamada
Masanobu
M
Tsukamoto
Norifumi
N
Nojima
Yoshihisa
Y
Nakazato
Yoichi
Y
Mori
Masatomo
M
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000309:Adrenal Insufficiency / Q000209:etiology*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D033162:Incidental Findings; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage
D058846:Antibodies, Monoclonal, Murine-Derived; D003561:Cytarabine; D000069283:Rituximab; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D011241:Prednisone