One-pot synthesis of chiral α-methylene-γ-lactams with excellent diastereoselectivities and enantioselectivities.
An efficient one-pot asymmetric synthesis of highly substituted γ-lactams containing α-methylene groups has been successfully developed. A wide range of γ-lactams could be obtained in high yields with excellent diastereomeric ratios of up to 99:1 in favor of trans isomers. In particular, excellent enantioselectivities of the two newly formed stereogenic centers with up to 99% ee were observed.
Shen
An
A
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Liu
Min
M
Jia
Zhen-Shan
ZS
Xu
Ming-Hua
MH
Lin
Guo-Qiang
GQ
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D007769:Lactams