Value of routine bone scans in patients with bone sarcomas before local treatment.
During modern treatment of children with bone sarcomas, the children undergo multiple diagnostic imaging procedures, including bone scan (BS) with Tc99m. The aim of the BS is to establish the metastatic status of the skeletal system at the time of initial diagnosis and thereafter. We retrospectively reviewed 85 medical charts of patients with osteosarcoma (n = 40) and Ewing sarcoma (n = 45) who had been treated in our department between 01.01.1995 and 01.11.2009. Every patient underwent routine imaging studies including BS at the time of initial diagnosis and before local treatment. Median age of all patients was 15.5 years (range, 8 to 29). Fifteen patients had metastases at diagnosis. All patients were treated with neoadjuvant chemotherapy. No patient with localized disease developed metastatic disease to the skeletal system before local treatment; those with localized disease who developed metastases did so some time after completion of the treatment plan. As the probability of developing bone metastatic disease while receiving therapy is very low, routine BS in asymptomatic patients before local treatment may safely be omitted.
Department of Pediatric Hematology Oncology, Meyer Children's Hospital, Haifa, Israel.
Doua
D
Bakri
Rachel
R
Bar-Shalom
Myriam Weyl
MW
Ben Arush
Sergey
S
Postovsky
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary; D055815:Young Adult
D000970:Antineoplastic Agents