The serum levels of Receptor Activator of Nuclear Factor-κB Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin do not correlate with the radiographically assessed severity of idiopathic hip and knee osteoarthritis.
OBJECTIVE
Determination of the serum levels of Receptor Activator of Nuclear Factor-Κb Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin in patients suffering from osteoarthritis of varying severity and healthy controls and correlation of these results with the patients' age and the radiographically assessed severity of the disease.


METHODS
Patients suffering from hip (n=58) or knee (n=117) osteoarthritis and matched controls (n=19) were enrolled in this study. Patients underwent physical examination and standard radiographic evaluation before blood sampling.


RESULTS
The serum levels of osteoprotegerin were positively correlated with age in all groups, whereas those of osteocalcin in the 'knee' group only. Osteoarthritis' severity and location did not have a statistically significant impact on the mean serum level of any marker in both groups.


CONCLUSIONS
Based on our results, none of the studied markers can serve as a surrogate for radiographic imaging in patients suffering from hip and knee osteoarthritis.
Eustathios Ι
EΙ
Kenanidis
Michael E
ME
Potoupnis
Kyriakos A
KA
Papavasiliou
Stauros
S
Pellios
Fares E
FE
Sayegh
George E
GE
Petsatodis
Nikolaos
N
Karatzas
George A
GA
Kapetanos
D000469:Alkaline Phosphatase / Q000097:blood; D006801:Humans; D020370:Osteoarthritis, Knee; D015675:Osteocalcin / Q000097:blood; D053244:Osteoprotegerin / Q000097:blood; D053245:RANK Ligand / Q000097:blood
D053244:Osteoprotegerin; D053245:RANK Ligand; D015675:Osteocalcin; D000469:Alkaline Phosphatase