Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.
German Cancer Research Center, DKFZ, Heidelberg, Germany.
Daniele
D
Campa
Anika
A
Hüsing
Jenny
J
Chang-Claude
Lucie
L
Dostal
Heiner
H
Boeing
Janine
J
Kröger
Anne
A
Tjønneland
Nina
N
Roswall
Kim
K
Overvad
Christina C
CC
Dahm
Laudina
L
Rodríguez
Núria
N
Sala
Maria José Sánchez
MJ
Pérez
Nerea
N
Larrañaga
Maria-Dolores
MD
Chirlaque
Eva
E
Ardanaz
Kay-Tee
KT
Khaw
Nick
N
Wareham
Naomi E
NE
Allen
Ruth C
RC
Travis
Antonia
A
Trichopoulou
Androniki
A
Naska
Christina
C
Bamia
Domenico
D
Palli
Sabina
S
Sieri
Rosario
R
Tumino
Carlotta
C
Sacerdote
Henk J
HJ
van Kranen
H
H
Bas Bueno-de-Mesquita
Pär
P
Stattin
Mattias
M
Johansson
Veronique
V
Chajes
Sabina
S
Rinaldi
Isabelle
I
Romieu
Afshan
A
Siddiq
Teresa
T
Norat
Elio
E
Riboli
Rudolf
R
Kaaks
Federico
F
Canzian
D000328:Adult; D000368:Aged; D064429:Fatty Acid Synthases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013002:Somatomedins / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D013002:Somatomedins; D064429:Fatty Acid Synthases