Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/β2-glycoprotein I complexes in postmenopausal women.
Oxidative stress and consequent oxidized lipoprotein production is thought to play a central role in both the initiation and progression of atherosclerosis. Oxidized low-density lipoprotein (oxLDL)/β2-glycoprotein I (β2GPI) complexes are etiologically important in the development of atherosclerosis. The aim of the present study was to investigate whether long-term treatment with conventional hormone replacement therapy (HRT) in postmenopausal women could affect total serum antioxidant capacity (TAC) and serum levels of oxLDL/β2GPI complexes. A total of 60 normolipidemic postmenopausal women treated with oral estrogen together with progestin therapy for 3 months were selected. TAC and serum levels of oxLDL/β2GPI complexes were measured at the beginning and end of the HRT. HRT led to a significant increase in TAC (15%, P=0.02) and a minor but statistically nonsignificant decrease of oxLDL/β2GPI complexes (3%, P=0.30) when compared with the baseline control levels. There was also no significant association between TAC and oxLDL/β2GPI complexes changes related to HRT. This study indicates that, HRT in postmenopausal women leads to an increase in TAC without an equivalent change in serum levels of oxLDL/β2GPI complexes. It is concluded that beneficial effects of HRT could be explained, at least in part, by improving antioxidant status, but may not be directly associated with a change in oxidized lipoprotein production.
Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam
M
Darabi
Mohsen
M
Ani
Ahmad
A
Movahedian
Elahe
E
Zarean
Mojtaba
M
Panjehpour
Mohammed
M
Rabbani
D000975:Antioxidants / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D017698:Postmenopause / Q000097:blood*; D011372:Progestins / Q000008:administration & dosage; D053482:beta 2-Glycoprotein I / Q000097:blood*
D000975:Antioxidants; D008076:Cholesterol, HDL; D008077:Lipoproteins, LDL; D011372:Progestins; D053482:beta 2-Glycoprotein I; C099252:oxidized low density lipoprotein