Evaluation of three brands of drug interaction software for use in intensive care units.
OBJECTIVE
To evaluate drug interaction software programs and determine their accuracy in identifying drug-drug interactions that may occur in intensive care units. Setting The study was developed in Brazil.


METHODS
Drug interaction software programs were identified through a bibliographic search in PUBMED and in LILACS (database related to the health sciences published in Latin American and Caribbean countries). The programs' sensitivity, specificity, and positive and negative predictive values were determined to assess their accuracy in detecting drug-drug interactions. The accuracy of the software programs identified was determined using 100 clinically important interactions and 100 clinically unimportant ones. Stockley's Drug Interactions 8th edition was employed as the gold standard in the identification of drug-drug interaction.


RESULTS
Sensitivity, specificity, positive and negative predictive values.


RESULTS
The programs studied were: Drug Interaction Checker (DIC), Drug-Reax (DR), and Lexi-Interact (LI). DR displayed the highest sensitivity (0.88) and DIC showed the lowest (0.69). A close similarity was observed among the programs regarding specificity (0.88-0.92) and positive predictive values (0.88-0.89). The DIC had the lowest negative predictive value (0.75) and DR the highest (0.91).


CONCLUSIONS
The DR and LI programs displayed appropriate sensitivity and specificity for identifying drug-drug interactions of interest in intensive care units. Drug interaction software programs help pharmacists and health care teams in the prevention and recognition of drug-drug interactions and optimize safety and quality of care delivered in intensive care units.
Faculty of Pharmacy, Federal University of Minas Gerais, Av. Antônio Carlos 6627, Campus Pampulha, 31270-010, Belo Horizonte, MG, Brazil. amreis@farmacia.ufmg.br
Adriano Max Moreira
AM
Reis
Silvia Helena De Bortoli
SH
Cassiani
D001938:Brazil; D004347:Drug Interactions / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units / Q000592:standards*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood; D012984:Software / Q000592:standards*
D004364:Pharmaceutical Preparations