Efficient microwave-assisted synthesis of 5-deazaflavine derivatives.
A series of pyrimido[4,5-b]quinolines (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N⁴-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.
Grupo de Investigación en Compuestos Heterocíclicos, Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, A.A.1890 Barranquilla, Colombia. jorgetrilleras@mail.uniatlantico.edu.co
Jorge
J
Trilleras
Luis Gabriel
LG
López
Dency José
DJ
Pacheco
Jairo
J
Quiroga
Manuel
M
Nogueras
José M de la
JM
Torre
Justo
J
Cobo
D000588:Amines / Q000737:chemistry; D003500:Cyclization; D005415:Flavins / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure
D000588:Amines; D005415:Flavins; C019319:5-deazaflavin