[Expression of survivin, SDF-1 and CXCR4 on tumor cells in ovarian cancer].
BACKGROUND
epithelial ovarian cancer (EOC) has the highest mortality rate among patients with gynecologic malignancies. Lack of specific and early symptoms and of screening tests causes that most patients are diagnosed in advanced stage of disease. Radical surgery followed by chemotherapy does not bring satisfactory curative effects.


OBJECTIVE
the urgent need exists to define the optimum biomarker for ovarian cancer to predict patients' response to curative therapy. Our current study aimed at correlation between the expression of survivin, SDF-1, CXCR-4 on tumor tissue and clinical outcome of patients with ovarian cancer.


RESULTS
We showed that survivin expression correlates with histological grading of the tumor. No correlation was found in terms of SDF-1/ CXCR-4 expression and clinicopathologic data.


CONCLUSIONS
further studies covering larger number of patients are needed to determine whether SDF-1 and CXCR-4 might be considered as biomarkers for ovarian cancer.
Nowak-Markwitz
Ewa
E
Klinika Onkologii Ginekologicznej, Katedra Ginekologii, Połoznictwa i Onkologii Ginekologicznej, Uniwersytet Medyczny, Poznań. ewamarkwitz@poczta.fm
Puła
Bartosz
B
Szajnik
Marta
M
Dziegiel
Piotr
P
Piotrowska
Aleksandra
A
Zabel
Maciej
M
Spaczyński
Marek
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D045744:Cell Line, Tumor; D054377:Chemokine CXCL12 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D019718:Receptors, CXCR4 / Q000378:metabolism*; D000077022:Survivin; D055815:Young Adult
C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D054377:Chemokine CXCL12; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D019718:Receptors, CXCR4; D000077022:Survivin