Aquaporin 1, a potential therapeutic target for migraine with aura.
The pathophysiology of migraine remains largely unknown. However, evidence regarding the molecules participating in the pathophysiology of migraine has been accumulating. Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases. This review outlines newly emerging evidence indicating that AQP-1 plays an important role in pain signal transduction and migraine and could therefore serve as a potential therapeutic target for these diseases.
Key Laboratory of Pain Research & Therapy, Department of Neurobiology and Institute of Neuroscience, Soochow University, Suzhou, P.R. China.
Guang-Yin
GY
Xu
Fen
F
Wang
Xinghong
X
Jiang
Jin
J
Tao
D000818:Animals; D051398:Aquaporin 1 / Q000737:chemistry / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology; D004827:Epilepsy / Q000150:complications* / Q000628:therapy*; D006801:Humans; D008881:Migraine Disorders / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D008954:Models, Biological; D009619:Nociceptors / Q000378:metabolism
D051398:Aquaporin 1