[Primary pharmacological screening of an endemic plant from the Southern Morocco (Tetraena gaetula [Emb. & Maire] Beier & Thulin)].
Tetraena gaetula (Emb. & Maire) Beier & Thulin (Zygophyllum gaetulum Emb. & Maire, Zygophyllaceae) is an endemic plant from the southern Morocco. This plant is widely used in Moroccan traditional medicine as an antispasmodic and antidiabetic. Our work aims to evaluate several pharmacological properties of extracts of T. gaetula such pro- or antiproliferative, immunomodulatory, analgesic and antidepressant effects. Initially, we studied intraperitoneally the acute toxicity of aqueous extract of T. gaetula in mice; the lethal dose 50 is 1.2 g/kg of body weight. Our results also showed a stimulating proliferative activity of T. gaetula, particularly at 6 μg/μL of the proteic extract on T lymphocytes. However, this same concentration of proteic extract induced rather cytotoxicity on B cells and macrophages. Our ex vivo results showed a dose-dependent response: (i) stimulation of lymphocyte subpopulations and monocytes in a dose 600 mg/kg, and (ii) immunosuppression at a dose 300 mg/kg. The pharmacological results in vivo showed a pronounced antidepressant effect of the proteic extract at all doses. However, the aqueous extract showed analgesic and anti-depressant effects, mainly at doses 300 and 600 mg/kg.
Laboratoire des molécules bioactives, faculté des sciences et techniques, Fès, Maroc.
Amal
A
El Hamsas El Youbi
Dalila
D
Bousta
Ibtissam
I
Ouahidi
Lotfi
L
Aarab
D000700:Analgesics; D000818:Animals; D000928:Antidepressive Agents; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000032:analysis; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009018:Morocco; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D028461:Zygophyllaceae / Q000737:chemistry*
D000700:Analgesics; D000928:Antidepressive Agents; D005419:Flavonoids; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D010936:Plant Extracts