New terpenoids, olibanumols D-G, from traditional Egyptian medicine olibanum, the gum-resin of Boswellia carterii.
A new prenylaromadendrane-type diterpene, olibanumol D (1), and three new oleanane- and lupane-type triterpenes, olibanumols E (2), F (3), and G (4), were isolated from the traditional Egyptian medicine olibanum, the exuded gum-resin from Boswellia carterii Birdw. Their structures were established mainly on the basis of 1D and 2D NMR spectral data. Compounds 1 and 2 exhibited nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse peritoneal macrophages.
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
Toshio
T
Morikawa
Hideo
H
Oominami
Hisashi
H
Matsuda
Masayuki
M
Yoshikawa
D000818:Animals; D029743:Boswellia / Q000737:chemistry*; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D053147:Plant Exudates / Q000737:chemistry / Q000494:pharmacology; D012116:Resins, Plant / Q000737:chemistry* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
D004224:Diterpenes; D008070:Lipopolysaccharides; D053147:Plant Exudates; D012116:Resins, Plant; D013729:Terpenes; D014315:Triterpenes; D009569:Nitric Oxide