Dynamic patient position changes during colonoscope withdrawal increase adenoma detection: a randomized, crossover trial.
BACKGROUND
Colonoscopy has a miss rate for adenomas that may partly relate to poor visualization of the colonic surface. Dynamic position changes during colonoscope withdrawal can improve luminal distension.


OBJECTIVE
To assess whether position changes also improve adenoma and polyp detection.


METHODS
Randomized crossover clinical trial.


METHODS
Academic endoscopy unit.


METHODS
This study involved 130 patients who presented for routine colonoscopy.


METHODS
Examination either entirely in the left lateral position followed by position changes (cecum to hepatic flexure, left lateral; transverse colon, supine; splenic flexure and descending colon, right lateral) or vice versa. After both examinations, polyps were removed for histopathology.


METHODS
Proportion of patients with ≥1 polyp or adenoma detected between the hepatic flexure and the sigmoid-descending colon junction. Luminal distension was measured on a scale of 1 to 5: 1, total collapse; 5, fully distended.


RESULTS
At least 1 adenoma was detected in 34% of patients in colon areas in which the patient position differed from left lateral (transverse colon, splenic flexure, descending colon) compared with 23% examined with the patient in the left lateral position alone (P = .01). At least 1 polyp was detected in 52% of patients with position changes versus 34% of patients examined in the left lateral position alone (P < .001). Adenoma and polyp detection were positively correlated with an improved distension score (correlation coefficient, 0.12; P < .001). Adenomas were detected in 16% of colon areas with adequate distension scores (4 and 5) compared with 7% of those with borderline or nondiagnostic scores (1-3; P < .001).


CONCLUSIONS
Single-operator study.


CONCLUSIONS
Dynamic position changes during colonoscope withdrawal significantly improved polyp and adenoma detection. (


BACKGROUND
NCT00234650).
East
James E
JE
Wolfson Unit for Endoscopy, St. Mark’s Hospital, Imperial College London, London. jameseast6@yahoo.com
Bassett
Paul
P
Arebi
Naila
N
Thomas-Gibson
Siwan
S
Guenther
Thomas
T
Saunders
Brian P
BP
D000236:Adenoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002432:Cecum / Q000473:pathology; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003111:Colonic Polyps / Q000175:diagnosis*; D003113:Colonoscopy / Q000379:methods*; D018592:Cross-Over Studies; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D056888:Patient Positioning; D016683:Supine Position