SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.
Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.
Broad Institute, Cambridge, MA 02142, USA.
D E
DE
Neafsey
Imperial College London, London SW7 2AZ, UK.
M K N
MKN
Lawniczak
Broad Institute, Cambridge, MA 02142, USA.
D J
DJ
Park
Imperial College London, London SW7 2AZ, UK.
S N
SN
Redmond
Malaria Research and Training Center, Bamako, Mali.
M B
MB
Coulibaly
Malaria Research and Training Center, Bamako, Mali.
S F
SF
Traoré
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso.
N
N
Sagnon
Institut de Recherche pour le Développement, Unité de Recherche R016, Montpellier, France.|Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Yaounde, Cameroon.
C
C
Costantini
Broad Institute, Cambridge, MA 02142, USA.
C
C
Johnson
Broad Institute, Cambridge, MA 02142, USA.
R C
RC
Wiegand
University of Notre Dame, Notre Dame, IN 46556, USA.
F H
FH
Collins
Broad Institute, Cambridge, MA 02142, USA.
E S
ES
Lander
Broad Institute, Cambridge, MA 02142, USA.|Harvard School of Public Health, Boston, MA 02115, USA.
D F
DF
Wirth
Imperial College London, London SW7 2AZ, UK.
F C
FC
Kafatos
University of Notre Dame, Notre Dame, IN 46556, USA.
N J
NJ
Besansky
Imperial College London, London SW7 2AZ, UK.
G K
GK
Christophides
Broad Institute, Cambridge, MA 02142, USA.|Harvard School of Public Health, Boston, MA 02115, USA.|Boston College, Chestnut Hill, MA 02467, USA.
M A T
MAT
Muskavitch
D000818:Animals; D000852:Anopheles / Q000235:genetics*; D005260:Female; D051456:Gene Flow; D017344:Genes, Insect; D005838:Genotype; D007303:Insect Vectors / Q000235:genetics*; D008288:Malaria; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*