Two mechanisms that account for major histocompatibility complex restriction of T cells.
In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiate signalling through the TCR complex. Both mechanisms are likely to be essential, but for different reasons.
Department of Biochemistry, University of Illinois 600 South Mathews Avenue, Urbana-Champaign, IL 61801 USA. d-kranz@illinois.edu
David M
DM
Kranz