Gout and its comorbidities.
Gout is a chronic disease in which excessively high levels of serum urate (hyperuricemia) result in tissue depositions of sodium urate crystals and intermittent inflammatory attacks. Patients who have gout frequently experience a range of comorbidities, which complicates management and affects long-term prognosis. We review some of the more important of these comorbidities and consider the extent to which gout or hyperuricemia may be either a consequence or a cause of these related conditions. In addition, we briefly consider several neurological conditions in which the presence of gout or a high serum urate level may be associated with less disease, rather than more.
New York University School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA. michael.pillinger@nyumc.org
Michael H
MH
Pillinger
David S
DS
Goldfarb
Robert T
RT
Keenan
D015897:Comorbidity; D006073:Gout / Q000453:epidemiology* / Q000628:therapy; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology* / Q000628:therapy; D040242:Risk Reduction Behavior; D016896:Treatment Outcome
D006074:Gout Suppressants