[T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy].
OBJECTIVE
To investigate the relationship between T cell receptor constant alpha chain (TCRCα) gene +1592C/T polymorphism and IgA nephropathy.


METHODS
TCRCα +1592C/T genotypes were identified by PCR-RFLP and direct sequencing in 244 Chinese Han patients with IgA nephropathy, who were classified according to their genotype into CC (188 cases), CT (54 cases) and TT (2 cases) groups. The clinical and pathological data of the patients were analyzed in relation to the TCRCα +1592C/T genotypes.


RESULTS
No significant differences in the clinical and biochemical indices were found in these patients with different TCRCα gene +1592C/T genotypes. TCRCα +1592C/T polymorphism was not found to contribute to severity or manifestations of renal pathology.


CONCLUSIONS
TCRCα+1592C/T polymorphism may not be associated with the susceptibility to IgA nephropathy in the Chinese Han population.
Li
Shi-liang
SL
Department of Nephrology, Affiliated Hospital, Youjiang Medical University for Nationalities, Baise 533000, China. lishiliang-6605850@163.com
Lin
Xu
X
Wang
Jie
J
Yang
Fa-fen
FF
You
Yan-wu
YW
Guo
Peng-wei
PW
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002648:Child; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D055815:Young Adult
D016693:Receptors, Antigen, T-Cell, alpha-beta