Efficacy of reconstruction of alveolar bone using an alloplastic hydroxyapatite tricalcium phosphate graft under biodegradable chambers.
Our aim was to test the efficacy of a synthetic alloplastic graft under biodegradable chambers to reconstruct a horizontal bony deficiency as an alternative to autogenous, allogeneic, or xenogenic grafts. We used 11 New Zealand white rabbits. On each rabbit's mandible one test sample (grafted chamber) was placed on the (right or left) body, while its control sample (empty (E) chamber) was placed on the other side. Twelve weeks postoperatively the animals were sacrificed and the samples extracted for gross assessment, micro-computed tomographic imaging, and histological and histomorphometric analyses. There was significantly more new bone with a greater surface area in the test group than in the control group, and the alloplastic graft was osteoconductive when used as an onlay graft under a synthetic biodegradable chamber. Synthetic products can be efficient alternatives to autogenic, allogeneic, or xenogenic grafts.
Almasri
Mazen
M
Oral Maxillofacial Surgery Dept., King Khalid University, Faculty of Dentistry, Saudi Arabia. mazen_ajm@yahoo.com
Altalibi
Mostafa
M
D020341:Absorbable Implants; D000539:Alveolar Process / Q000473:pathology; D000543:Alveoloplasty / Q000379:methods*; D000818:Animals; D015519:Bone Density / Q000502:physiology; D001863:Bone Screws; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics; D004867:Equipment Design; D005260:Female; D006882:Hydroxyapatites / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D019344:Lactic Acid / Q000737:chemistry; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D008567:Membranes, Artificial; D010012:Osteogenesis / Q000502:physiology; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits; D011897:Random Allocation; D019651:Plastic Surgery Procedures / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D055114:X-Ray Microtomography
D018786:Bone Substitutes; D006882:Hydroxyapatites; D008567:Membranes, Artificial; C074950:hydroxyapatite-beta tricalcium phosphate; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid