Copper-catalyzed synthesis of quinazoline derivatives via Ullmann-type coupling and aerobic oxidation.
A simple and efficient copper-catalyzed approach to quinazoline derivatives has been developed, and the protocol uses readily available substituted (2-bromophenyl)methylamines and amides as the starting materials, and the cascade reactions were performed under air via sequential Ullmann-type coupling and aerobic oxidation without addition of any ligand or additive. The present method provides a convenient and practical strategy for synthesis of quinazoline derivatives.
Wang
Chen
C
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
Li
Shangfu
S
Liu
Hongxia
H
Jiang
Yuyang
Y
Fu
Hua
H
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D008744:Methylamines / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
D008024:Ligands; D008744:Methylamines; D011799:Quinazolines; D003300:Copper