Variable time-delay estimation for anesthesia control during intensive care.
The presence of artifacts plays a crucial role in automatic sedation systems and may introduce variable time delays (TDs) in the closed-loop-control structures. This paper presents a successful procedure to estimate the varying TD of the bispectral index (BIS) monitor used in closed-loop control during intensive care. The TD estimation (TDE) is based on the cross-correlation analysis technique and the method is validated with real measured signals of propofol and BIS. Extended prediction self-adaptive control is used in combination with a Smith predictor to reduce the computational burden imposed by the variable TD. The conclusion is that an online TDE of the BIS monitor improves the performance of the closed-loop system for reference tracking, disturbance rejection, and overall stability.
Ionescu
Clara M
CM
Department of Electrical Energy, Systemsand Automation, Ghent University, Gent-Zwijnaarde 9052, Belgium. claramihaela.ionescu@ugent.be
Hodrea
Ramona
R
De Keyser
Robin
R
D000368:Aged; D000465:Algorithms; D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003198:Computer Simulation; D056805:Consciousness Monitors; D003422:Critical Care / Q000379:methods*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D008991:Monitoring, Physiologic / Q000379:methods; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted
D018686:Anesthetics, Intravenous; D015742:Propofol