Host genetics and HIV-1: the final phase?
This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.
Fellay
Jacques
J
Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America. jacques.fellay@duke.edu
Shianna
Kevin V
KV
Telenti
Amalio
A
Goldstein
David B
DB
D015331:Cohort Studies; D018450:Disease Progression; D014644:Genetic Variation / Q000502:physiology; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology* / Q000517:prevention & control / Q000628:therapy; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D017053:Infection Control; D008954:Models, Biological; D016896:Treatment Outcome