CYP1A1 polymorphism in adolescents with polycystic ovary syndrome.
OBJECTIVE
To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females.


METHODS
The CYP1A1 Ile/Val polymorphism was analyzed by collecting DNA samples from 44 adolescents with polycystic ovary syndrome (PCOS)--according to the Rotterdam criteria--and 120 healthy female controls aged 13-18 years in Ankara, Turkey.


RESULTS
There was a 2.5-fold increase in the frequency of the CYP1A1 Ile/Val genotype in adolescents with PCOS compared with the control group (odds ratio [OR] 2.54; 95% confidence interval [CI], 1.143-5.637; P<0.001), in addition to a 2.4-fold increase in the frequency of the Val allele (OR 2.43; 95% CI, 1.099-5.397; P<0.001).


CONCLUSIONS
The data show an association between CYP1A1 and PCOS, indicating that variant alleles of the gene may affect the metabolic and transport pathway of estrogens, thus causing PCOS.
Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. sinemhusnu@yahoo.com
Sinem
S
Akgül
Orhan
O
Derman
Mehmet
M
Alikaşifoğlu
Dilek
D
Aktaş
D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey
D019363:Cytochrome P-450 CYP1A1