[Transformation of physiological gastroprotective effects of glucocorticoids into pathological ulcerogenic consequences].
The study was designed to investigate how physiological gastroprotective action of glucocorticoids could be transformed to pathological proulcerogenic effect. Time-dependent effects of single injection of dexamethasone on stress-induced gastric erosions, corticosterone and blood glucose levels, somatic parameters were investigated in fasted rats. Dexamethasone injected at the same dose attenuated or aggravated the stress-induced gastric erosions depending on the time of the injection. In case of dexamethasone injection 1-12 hrs before stress, we observed its gastroprotective action. Further increase in the time interval caused transformation of the gastroprotective action of dexamethasone to proulcerogenic effect. Accordingly to the results obtained, dexamethasone-induced long-lasting maintenance of blood glucose levels accompanied with signs of catabolic effect as well as dexamethasone-induced corticosterone deficiency may be responsible, at least partly, for the transformation of gastroprotective effect of dexamethasone to the proulcerogenic one.
L P
LP
Filaretova
T R
TR
Bagaeva
O Iu
OIu
Morozova
T T
TT
Podvigina
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003345:Corticosterone / Q000037:antagonists & inhibitors / Q000097:blood*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D005215:Fasting; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D007103:Immobilization; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000097:blood / Q000139:chemically induced* / Q000473:pathology / Q000523:psychology; D013315:Stress, Psychological / Q000097:blood / Q000473:pathology; D013997:Time Factors
D001786:Blood Glucose; D005938:Glucocorticoids; D003907:Dexamethasone; D003345:Corticosterone