Radiofrequency radiation at 40 kHz induces hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model for human Wilson disease.
In the present study, we examined effects of radiofrequency (RF) radiation at 40 kHz on hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model for human Wilson disease, which is a heritable disease of copper metabolism in the liver. The activities of ALT and AST in serum of LEC rats exposed to RF radiation for 2 weeks were approximately 3.8-fold and 2-fold higher than those in serum of sham-exposed rats, respectively. Although there were no significant differences in hepatic copper contents between LEC rats exposed to RF radiation for 2 weeks and sham-exposed rats, copper contents in the kidney and serum of exposed LEC rats were approximately 4.2-fold and 12.9-fold higher than those in sham-exposed rats, respectively. Relative O₂⁻-scavenging activities in the S-100 fraction of the liver of LEC rats exposed to RF radiation for 2 weeks were 1.6-fold higher than those in sham-exposed rats. No significant differences were observed in activities of AST and ALT in serum and relative O₂⁻-scavenging activity in the S-100 fraction of the liver of normal control WKAH rats that were sham-exposed and exposed to RF radiation. No significant differences were observed in copper contents in the liver, kidney and serum of WKAH rats that were sham-exposed and exposed to RF radiation for 2 weeks. The results show that RF radiation at 40 kHz induced hepatic injury in LEC rats.
Sakai
Hiroshi
H
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu.
Horiguchi
Noboru
N
Endoh
Daiji
D
Nakayama
Kenji
K
Hayashi
Masanobu
M
D000818:Animals; D004195:Disease Models, Animal; D016166:Free Radical Scavengers; D006527:Hepatolenticular Degeneration / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D020332:Rats, Inbred LEC; D013481:Superoxides
D016166:Free Radical Scavengers; D013481:Superoxides