Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances.
This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the development of more effective ways for disease management.
Kumar
Dhiraj
D
Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India. dhiraj@icgeb.res.in
Rao
Kanury V S
KV
D000818:Animals; D001343:Autophagy / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D050356:Lipid Metabolism; D009161:Mycobacterium / Q000276:immunology / Q000502:physiology*; D009164:Mycobacterium Infections / Q000378:metabolism / Q000382:microbiology*; D015398:Signal Transduction / Q000235:genetics