Autophagy gets in on the regulatory act.
Autophagy down-regulates the Wnt signal transduction pathway via targeted degradation of a key signaling protein. This may provide an explanation for autophagy's role in tumor suppression.
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.
Steven K
SK
Backues
Daniel J
DJ
Klionsky
D000818:Animals; D001343:Autophagy; D002477:Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism
D051153:Wnt Proteins