[Factors associated with recurrence and prognosis in patients with gastric gastrointestinal stromal tumors].
OBJECTIVE
To investigate factors associated with postoperative recurrence and prognosis in gastric gastrointestinal stromal tumors(gastric GIST).


METHODS
Clinical data of 107 patients with gastric GIST who underwent surgical resection at the Zhejiang Province Hospital of the Integrated Traditional Chinese and Western Medicine between January 1987 and December 2008 were analyzed retrospectively. Factors associated with recurrence were explored.


RESULTS
Surgery was radical in 83 patients(radical group) and palliative in 24 patients(palliative group). Thirty-one patients developed recurrence in the radical group. Tumor size greater than 5 cm, incompleteness of tumor envelope, and local invasion were associated with tumor recurrence(P<0.05), while gender, age, tumor location, and mitosis were not. The median survival time was 13 months in patients with recurrence and 78 month in those without recurrence, and the difference was statistically significant(P<0.05). The median survival was 54(range, 7-246) months in the radical group and 6 (range, 1-25) in the palliative group, and the difference was also statistically significant(P<0.05).


CONCLUSIONS
Tumor size, integrity of tumor envelope, and local invasion are predictive for recurrence in GIST.
Department of General Surgery, Zhejiang Province Hospital of The Integrated Traditional Chinese and Western Medicine, Hangzhou 310003, China. chongyang_1109@163.com
Chong
C
Yang
Ying
Y
Kong
Ping
P
Wang
Bing
B
Dong
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*