Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo.
Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.
Institut Pasteur de Lille, Lactic Acid Bacteria & Mucosal Immunity, Center for Infection and Immunity of Lille, 1, Rue du Pr Calmette, BP 245, F-59019 Lille, France.
Benoît
B
Foligné
Stéphanie-Marie
SM
Deutsch
Jérôme
J
Breton
Fabien J
FJ
Cousin
Joëlle
J
Dewulf
Michel
M
Samson
Bruno
B
Pot
Gwénaël
G
Jan
D000818:Animals; D002478:Cells, Cultured; D003092:Colitis / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D016753:Interleukin-10 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000382:microbiology; D051379:Mice; D019936:Probiotics / Q000494:pharmacology*; D011424:Propionibacterium / Q000276:immunology* / Q000502:physiology*
D007155:Immunologic Factors; D016753:Interleukin-10