Tapioca starch graft copolymers and Dome Matrix® modules II. Effect of modules assemblage on riboflavin release kinetics.
This paper studies the Riboflavin release from systems made of assembled modules of Dome Matrix® technology using tapioca starch-ethylmethacrylate (TSEMA) and tapioca hydroxypropylstarch-ethylmethacrylate (THSEMA) graft copolymers produced by two different drying methods. Two different shape modules were manufactured for this study, i.e., female and male modules, in order to facilitate their assemblage in "void configuration", a system with an internal void space. Drug release studies on void configurations based on THSEMA show faster releases than TSEMA; HPMC systems used as a comparative reference showed intermediate release. Moreover, using void configurations made with one module of TSEMA and the other of THSEMA is possible to average the drug release, without difference between the drying methods used for the polymers. With respect to the floatation characteristics, all the void configurations floated immediately and, due to the mass center of the system, the floatation position of the system was always axial with the female module up and the male down. The drug release studies performed with a sinker to force the immersion of the systems in the medium did not show differences with respect to the dissolution test without a sinker. The combination of floatation capability of the assembled modules and the prolonged drug release provided with the graft copolymers make these assembled modules candidates as controlled release gastro-retentive dosage forms.
Dpto. Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, Sevilla, Spain.
Marta
M
Casas
Orazio Luca
OL
Strusi
M Rosa
MR
Jiménez-Castellanos
Paolo
P
Colombo
D000465:Algorithms; D055598:Chemical Phenomena; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D005772:Gastrointestinal Transit; D007700:Kinetics; D002365:Manihot / Q000737:chemistry*; D008768:Methylmethacrylates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012256:Riboflavin / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013213:Starch / Q000031:analogs & derivatives / Q000737:chemistry*; D013607:Tablets
D003692:Delayed-Action Preparations; D005079:Excipients; D008768:Methylmethacrylates; D011108:Polymers; D013607:Tablets; C009931:poly(ethylmethacrylate); D013213:Starch; C046042:2-hydroxypropyl starch; D012256:Riboflavin