Role of stem cells in kidney repair.
End-stage renal disease and acute renal failure are the most important issues of practical and clinical nephrology, bearing in mind their high mortality rate, solely symptomatic treatment, and overall economic impact on society. The advances in stem cell biology opened the door for the new era in treatment of many disorders, including renal, offering new therapeutical solutions. Findings suggesting that the adult kidney contains stem cells and that stem cells from bone marrow have potential to differentiate into renal cells focused research on the possible application of these cells in therapy of kidney disorders. The other promising candidates for stem cell therapy for the kidney are embryonic stem cells and amniotic fluid-derived stem cells. This article focuses on the characteristics and possible application of these types of stem cells.
Faculty of Medicine, University of Nis, Nis, Serbia.
Vladimir
V
Petrovic
Ivan
I
Jovanovic
Ivana
I
Pesic
Vladisav
V
Stefanovic
D000653:Amniotic Fluid / Q000166:cytology; D053595:Embryonic Stem Cells / Q000637:transplantation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation