Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.
Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the formation of the products. The antimycobacterial activity of the isomeric compounds has been tested against Mycobacterium tuberculosis (MTB).
Manikannan
Ramaiyan
R
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
Venkatesan
Ramaiyan
R
Muthusubramanian
Shanmugam
S
Yogeeswari
Perumal
P
Sriram
Dharmarajan
D
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D004126:Dimethylformamide; D005559:Formamides / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D005559:Formamides; D011720:Pyrazoles; D013440:Sulfides; D004126:Dimethylformamide