Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group.
BACKGROUND
Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia.


METHODS
Mothers of 443 cases of infant leukaemia diagnosed during 1996-2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression.


RESULTS
We observed no associations between prenatal vitamin (odds ratio (OR)=0.79, 95% confidence interval (CI): 0.44-1.42) or iron supplementation (OR=1.07, 95% CI: 0.75-1.52) and infant leukaemia after adjustment for race/ethnicity and income. Similar results were observed for leukaemia subtypes analysed separately.


CONCLUSIONS
The observed null associations may be attributable to high supplementation rates and/or national fortification programmes.
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, MMC 422, Minneapolis, MN 55455, USA.
A M
AM
Linabery
S E
SE
Puumala
J M
JM
Hilden
S M
SM
Davies
N A
NA
Heerema
M A
MA
Roesler
J A
JA
Ross
D000328:Adult; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage*; D007938:Leukemia / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D011247:Pregnancy; D012306:Risk; D014815:Vitamins / Q000008:administration & dosage*
D019266:Iron, Dietary; D014815:Vitamins