Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells.
In this work, a paramagnetic nanofibrous composite film was fabricated with poly lactide, hydroxyapatite and γ-Fe(2)0(3) nanoparticles using the electrospinning technique. The composite film significantly enhanced the proliferation, differentiation and ECM secretion of the osteoblast cells under a static magnetic field, which offers promising application potentials in bone tissue engineering and bone regeneration therapy.
Meng
Jie
J
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhang
Yu
Y
Qi
Xiaojin
X
Kong
Hua
H
Wang
Chaoying
C
Xu
Zhen
Z
Xie
Sishen
S
Gu
Ning
N
Xu
Haiyan
H
D000818:Animals; D001861:Bone Regeneration; D002454:Cell Differentiation; D002460:Cell Line; D049109:Cell Proliferation; D017886:Durapatite / Q000737:chemistry; D005109:Extracellular Matrix / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D008280:Magnetics; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology*; D011091:Polyesters / Q000737:chemistry; D023822:Tissue Engineering
D005290:Ferric Compounds; D011091:Polyesters; C000499:ferric oxide; C033616:poly(lactide); D017886:Durapatite