Increased osteoprotegerin levels in women with previous gestational diabetes developing metabolic syndrome.
Osteoprotegerin (OPG), a novel soluble member of tumour necrosis factor receptor superfamily, has been shown to link cardiovascular disorders. The aim of this study is to investigate the potential relationship between serum OPG levels, cardiovascular risk factors and metabolic syndrome in a relatively large group of women with previous GDM. In this cross-sectional case-control study, 128 women with previous GDM and 67 age-matched controls were enrolled. Subjects were evaluated for the diagnosis of metabolic syndrome according to the criteria of the American Heart Association (AHA). Fasting glucose, insulin, serum lipids, CRP and OPG were assayed. HOMA score was calculated. Carotid intima media thickness (IMT) was measured. There was no significant increase in OPG levels in women with previous GDM when compared to controls. On the other hand, women with previous GDM developing metabolic syndrome had higher OPG levels than those without metabolic syndrome and healthy controls. Serum OPG levels were associated with obesity, insulin resistance, serum CRP and carotid IMT. Serum OPG is related to cardiovascular risk factors and metabolic syndrome, and might be involved in the development of cardiovascular disorders in women with previous GDM.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey. barisakincimd@gmail.com
Baris
B
Akinci
Aygul
A
Celtik
Faize
F
Yuksel
Sinan
S
Genc
Serkan
S
Yener
Mustafa
M
Secil
Mehmet Ali
MA
Ozcan
Sena
S
Yesil
D000328:Adult; D050197:Atherosclerosis / Q000209:etiology; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D009765:Obesity / Q000150:complications; D053244:Osteoprotegerin / Q000097:blood*; D011247:Pregnancy; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014421:Turkey / Q000453:epidemiology; D014463:Ultrasonography
D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D002097:C-Reactive Protein