Phospholipase A2 inhibitors (βPLIs) are encoded in the venom glands of Lachesis muta (Crotalinae, Viperidae) snakes.
Phospholipase A(2) inhibitors (PLIs) are glycoproteins secreted by snake liver into the circulating blood aiming the self-protection against toxic venom phospholipases A(2). In the present study, we describe the first complete nucleotide sequence of a βPLI from venom glands of a New World snake, Lachesis muta. The deduced primary structure was compared to other known βPLIs and recent literature findings of other possible roles of PLIs in snakes are discussed.
Lima
Rebeca Mascarenhas
RM
Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Rua Conde Pereira Carneiro 80, CEP 30510-010, Belo Horizonte, MG, Brazil.
Estevão-Costa
Maria Inácia
MI
Junqueira-de-Azevedo
Inácio L M
IL
Ho
Paulo Lee
PL
Diniz
Marcelo Ribeiro Vasconcelos
MR
Fortes-Dias
Consuelo Latorre
CL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017837:Bothrops / Q000378:metabolism*; D003435:Crotalid Venoms / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel; D004791:Enzyme Inhibitors; D005088:Exocrine Glands / Q000378:metabolism*; D054513:Group IV Phospholipases A2 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data
D003435:Crotalid Venoms; D004791:Enzyme Inhibitors; D054513:Group IV Phospholipases A2