OMiR: Identification of associations between OMIM diseases and microRNAs.
A large number of loci for genetic diseases have been mapped on the human genome and a group of hereditary diseases among them have thus far proven unsuccessful to clone. It is conceivable that such "unclonable" diseases are not linked to abnormalities of protein coding genes (PCGs), but of non-coding RNAs (ncRNAs). We developed a novel approach termed OMiR (OMIM and miRNAs), to test whether microRNAs (miRNAs) exhibit any associations with mapped genetic diseases not yet associated with a PCG. We found that "orphan" genetic disease loci were proximal to miRNA loci more frequently than to loci for which the responsible protein coding gene is known, thus suggesting that miRNAs might be the elusive culprits. Our findings indicate that inclusion of miRNAs among the candidate genes to be considered could assist geneticists in their hunt for disease genes, particularly in the case of rare diseases.
Rossi
Simona
S
Dept. of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA. Isidore.Rigoutsos@jefferson.edu
Tsirigos
Aristotelis
A
Amoroso
Antonio
A
Mascellani
Nicoletta
N
Rigoutsos
Isidore
I
Calin
George A
GA
Volinia
Stefano
S
D019295:Computational Biology / Q000379:methods*; D057225:Data Mining; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics*; D008040:Genetic Linkage; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D013223:Statistics as Topic
D035683:MicroRNAs