Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases.
Lennox-Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox-Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide.
Cuzzola
Antonella
A
Hôpital Henri Gastaut, Centre Saint-Paul, Marseille, France.
Ferlazzo
Edoardo
E
Italiano
Domenico
D
Calabrò
Rocco Salvatore
RS
Bramanti
Placido
P
Genton
Pierre
P
D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy; D000078334:Lacosamide; D065768:Lennox Gastaut Syndrome; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy
D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide