Model study on the clinical signs and residue concentrations of sublethal carbofuran poisoning in birds.
The incidence of fatal poisoning of birds of prey caused by carbofuran has increased markedly in Hungary since 2007. An experimental model with broiler chickens was used to study clinical signs of sublethal carbofuran poisoning in birds and to measure the residue concentrations of carbamate in tissues after exposure. Eight chickens were treated with a carbofuran-containing insecticide orally by gastric tube at a single dose of 2.5 mg/kg body weight, and clinical signs of poisoning were observed. Gas chromatography was used to determine carbofuran concentrations in the blood, muscle, and liver samples, and in stomach contents. Poisoning was characterized by typical muscarinic and nicotinic clinical signs without mortality. Carbofuran in the stomach and edible tissues of acutely poisoned birds may lead to secondary poisoning of predators and may also present risks to human health.
Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, 2 István st. H-1078 Budapest, Hungary. lehel.jozsef@aotk.szie.hu
J
J
Lehel
P
P
Laczay
J
J
Déri
E G
EG
Darin
P
P
Budai
D000818:Animals; D000835:Animals, Wild; D001715:Bird Diseases / Q000139:chemically induced*; D001717:Birds; D002235:Carbofuran / Q000032:analysis / Q000506:poisoning*; D002645:Chickens; D005260:Female; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D006814:Hungary; D007306:Insecticides / Q000506:poisoning*; D008099:Liver / Q000737:chemistry; D008297:Male; D023421:Models, Animal; D010573:Pesticide Residues / Q000032:analysis* / Q000378:metabolism / Q000506:poisoning; D011041:Poisoning / Q000662:veterinary
D007306:Insecticides; D010573:Pesticide Residues; D002235:Carbofuran