Gene regulation: the cohesin ring connects developmental highways.
How does cohesin regulate gene expression and development independently of its roles in sister chromatid cohesion and chromosome segregation? Recent studies show that cohesin, through multiple mechanisms, directly controls transcription of genes that regulate morphogenesis, differentiation, cell proliferation and pluripotency.
Dorsett
Dale
D
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D004440:Ecdysone / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics; D051379:Mice; D009024:Morphogenesis / Q000235:genetics*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D012469:Salivary Glands / Q000378:metabolism; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D004440:Ecdysone; D000097722:Cohesins; C119839:nipped-B protein, Drosophila