[Omega-3 fatty acids in parenteral nutrition: are they what makes the difference?].
Omega-3 fatty acids derived from fish oil have constantly been in the limelight in recent years because of their beneficial effects on health. In the field of parenteral nutrition, fish oil-based lipid emulsions also have shown very promising results with regard to parenteral-nutrition-associated liver disease (PNALD) and in comparison with soybean-oil derived emulsions. The latter are especially rich in omega-6 fatty acids, with pro-inflammatory characteristics. It is not clear, however, which effects can be attributed to the omega-3 fatty acids in fish oil, with their anti-inflammatory profile, since studies employed different lipid doses for soybean- and fish oil emulsions. In addition, antioxidants and potentially toxic plant sterols play a role. There is a clear need for adequate controlled studies to clarify these effects.
Universitair Medisch Centrum St. Radboud, Darmfalen Unit, afd. Maag-, Darm-, en Leverziekten, Nijmegen, the Netherlands. g.wanten@mdl.umcn.nl
Geert
G
Wanten
D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000009:adverse effects; D005395:Fish Oils / Q000737:chemistry*; D006801:Humans; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D013024:Soybean Oil
D005217:Fat Emulsions, Intravenous; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D013024:Soybean Oil