Monitoring serum chondroitin sulfate levels in patients submitted to coronary artery bypass surgery.
Glycosaminoglycans (GAGs) are functionally important molecules of the arterial wall and play a crucial role in atherogenesis. Chondroitin sulfate/dermatan sulfate proteoglycans (CS/DSPGs) participate in several biological events through their GAG chains, and are also involved in the development of atherosclerosis. The aim of this study was to compare the pre- and post-operative levels of CS in serum of patients after coronary artery bypass graft surgery using a highly sensitive reversed-polarity capillary electrophoresis method and to investigate the correlation of CS with common biochemical lipid markers. It was found that CS values were significantly higher for all patients post-operatively and, furthermore, CS levels were statistically correlated to apolipoprotein A and B levels. Notably, the pre-operational lipid profile of the patient may be indicative of the values of 4-sulfated CS post-operationally. Furthermore, the obtained results highlight the clinical significance of CS levels in serum, since they may provide complementary information for the latent inflammatory state of the patient.
Karangelis
D
D
Department of Cardiovascular and Thoracic Surgery, University of Thessaly, Larissa, Greece.
Asimakopoulou
A
A
Kanakis
I
I
Tagarakis
G I
GI
Koufakis
T
T
Triposkiadis
F
F
Tsilimingas
N
N
Karamanos
N K
NK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015415:Biomarkers / Q000097:blood; D011508:Chondroitin Sulfate Proteoglycans / Q000097:blood; D002809:Chondroitin Sulfates / Q000097:blood*; D001026:Coronary Artery Bypass; D016903:Drug Monitoring / Q000379:methods; D019075:Electrophoresis, Capillary; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D012680:Sensitivity and Specificity
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D015415:Biomarkers; D011508:Chondroitin Sulfate Proteoglycans; D002809:Chondroitin Sulfates