[Methods of BMP immobilization and evaluation for Ti-based dental implant surface modification].
Ti-based biomaterial has been widely used as dental and bone implant material although its bioactivity still needs improvement especially for dental implant. The bone morphogenetic proteins(BMPs) bound to Ti-based materials will attract the mesenchymal stem cells to differentiate into osteoblast cells, which benefits the response to the protein-material surface, and finally leads to new bone formation. Several methods including physically mixing, coating, plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials. The latest research papers are focused on the structure and function of BMPs, and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.
Center for Biomedical Materials and Tissue Engineering Research, Peking University Academy for Advanced Interdisciplinary Studies, Beijing 100871, China.
Xiao-shuai
XS
Ren
Shi-cheng
SC
Wei
Xiao-dong
XD
Su
D019485:Bone Morphogenetic Proteins / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D006801:Humans; D055767:Immobilized Proteins / Q000187:drug effects; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology; D019736:Prostheses and Implants; D014025:Titanium / Q000737:chemistry*
D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D055767:Immobilized Proteins; D014025:Titanium