The pathogenic role of Maillard reaction in the aging eye.
The proteins of the human eye are highly susceptible to the formation of advanced glycation end products (AGEs) from the reaction of sugars and carbonyl compounds. AGEs progressively accumulate in the aging lens and retina and accumulate at a higher rate in diseases that adversely affect vision such as, cataract, diabetic retinopathy and age-related macular degeneration. In the lens AGEs induce irreversible changes in structural proteins, which lead to lens protein aggregation and formation of high-molecular-weight aggregates that scatter light and impede vision. In the retina AGEs modify intra- and extracellular proteins that lead to an increase in oxidative stress and formation of pro-inflammatory cytokines, which promote vascular dysfunction. This review outlines recent advances in AGE research focusing on the mechanisms of their formation and their role in cataract and pathologies of the retina. The therapeutic action and pharmacological strategies of anti-AGE agents that can inhibit or prevent AGE formation in the eye are also discussed.
Nagaraj
Ram H
RH
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA. ram.nagaraj@case.edu
Linetsky
Mikhail
M
Stitt
Alan W
AW
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005128:Eye Diseases / Q000378:metabolism* / Q000473:pathology; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015416:Maillard Reaction; D015394:Molecular Structure; D012160:Retina / Q000378:metabolism
D017127:Glycation End Products, Advanced