Wegener's granulomatosis complicated by pulmonary embolism: a case report and review of the literature.
We describe the case of a 79-year-old lady who developed pulmonary emboli on a background of active Wegener's granulomatosis (WG). The literature reports an increased association of venous thromboembolic disease and the small vessel vasculitides, including WG. This case report explores the issues surrounding systemic anticoagulation in the context of a systemic vasculitis that predisposes to severe bleeding, in particular from the respiratory tract.
Hughes
Michael
M
Guy's and St. Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK. Michael.Hughes83@hotmail.co.uk
Burgess
James
J
Parekh
Nikesh
N
D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013902:Radiography, Thoracic; D016896:Treatment Outcome
D000925:Anticoagulants; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide