Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.
BACKGROUND
Although the ingestion of a dose of colchicine lower than 0.5 mg/kg is usually complicated by a mortality rate less than 5%, severe complications may be associated with drug-drug interactions in case of overdose combining other drugs.


METHODS
A 33-year-old previously healthy woman was admitted after a drug overdose combining colchicine, atorvastatin, ibuprofen, diclofenac, and furosemide. The amount of colchicine ingested was exactly 20 mg, corresponding to 0.33 mg/kg. Despite this relatively low dose, she presented the clinical course that is usually seen with much larger colchicine ingestions. She developed acute renal and liver failure, acute lung injury, pancytopenia with sepsis, rhabdomyolysis, hypertriglyceridemia, and ultimately died on Day 14 from hyperammonemic encephalopathy, refractory hypoxemia, and cardiac arrhythmias.


CONCLUSIONS
Serious drug-drug interactions may have complicated colchicine poisoning. In particular, atorvastatin, an inhibitor of P-glycoprotein and cytochrome P450 3A4, was likely responsible for an increased severity of rhabdomyolysis. In addition, propofol used for sedation during mechanical ventilation may have induced symptoms consistent with "propofol infusion syndrome," with further muscular injury and hypertriglyceridemia. The mechanism of death was unusual and similar to Reye's syndrome.
Department of Intensive Care, Université Catholique de Louvain, Cliniques St-Luc, Brussels, Belgium.
Virginie
V
Montiel
Vincent
V
Huberlant
Marie-Françoise
MF
Vincent
Frédéric
F
Bonbled
Philippe
P
Hantson
D000328:Adult; D000069059:Atorvastatin; D003078:Colchicine / Q000506:poisoning*; D003422:Critical Care; D051544:Cytochrome P-450 CYP3A; D065692:Cytochrome P-450 CYP3A Inhibitors; D062787:Drug Overdose; D005260:Female; D006538:Heptanoic Acids / Q000506:poisoning; D006801:Humans; D009102:Multiple Organ Failure / Q000139:chemically induced*; D015742:Propofol / Q000506:poisoning; D011758:Pyrroles / Q000506:poisoning; D012206:Rhabdomyolysis / Q000139:chemically induced
D065692:Cytochrome P-450 CYP3A Inhibitors; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D003078:Colchicine; D015742:Propofol