Relationship between degree of chromosomal aberration and survival in intestinal-type gastric cancer - a preliminary report based on three cases of hepatic metastasized gastric cancer with long-time survival.
BACKGROUND
Gastric cancer is one of the most frequent malignancies worldwide. More than 50% of all patients present with advanced stage of disease, with long-time survival of less than 5%. In selected subgroups, palliative gastric resection seems to be beneficial for survival and improved quality of the remaining life time, but is still controversially discussed.


METHODS
We report 3 cases of patients with intestinal-type advanced gastric cancer. All patients presented preoperatively with stage IV disease with liver metastases. The patients underwent palliative gastric resection and subsequent palliative chemotherapy. We performed a genome-wide DNA analysis of 9 gastric cancer tissue specimens using the DNA microchip array technique.


RESULTS
4 and 6 years after palliative surgery and chemotherapy, 2 of the patients show no signs of recurrence, while the third patient shows stable disease under third-line chemotherapy 4 years after the initial diagnosis. Comparative genetic analysis of 9 gastric cancer tissue specimens suggested that the degree of chromosomal aberration was closely related to survival for intestinal-type gastric cancers.


CONCLUSIONS
Palliative gastric resection is beneficial for survival and quality of life in selected patients. Determination of the degree of chromosomal aberrations might be helpful in predicting the response on multimodal treatment in intestinal-type gastric cancer. A better understanding of molecular biology is needed to define prognosis markers and molecular targets.
Dittmar
Yves
Y
Department of General, Visceral and Vascular Surgery, University of Jena, Germany. volkerjacobs@hotmail.com
Posorski
Nicole
N
Rauchfuss
Falk
F
Voigt
Rigo
R
Heise
Michael
M
Jandt
Karin
K
Gajda
Mieczyslav
M
Settmacher
Utz
U
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics; D005858:Germany; D006801:Humans; D015994:Incidence; D007414:Intestinal Neoplasms / Q000235:genetics / Q000401:mortality / Q000628:therapy; D008113:Liver Neoplasms / Q000235:genetics / Q000401:mortality* / Q000517:prevention & control / Q000556:secondary* / Q000628:therapy; D008137:Longitudinal Studies; D008297:Male; D010166:Palliative Care / Q000706:statistics & numerical data*; D010865:Pilot Projects; D018570:Risk Assessment; D012307:Risk Factors; D013223:Statistics as Topic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D016019:Survival Analysis; D015996:Survival Rate