A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.
Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.
Segalen
Isabelle
I
EA 2216 Immunology and Pathology and IRF148 ScInBioS, European University of Brest, France.
Fali
Tinhinane
T
Pers
Jacques-Olivier
JO
Le Meur
Yann
Y
Youinou
Pierre
P
Loisel
Séverine
S
D000208:Acute Disease; D000818:Animals; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans