Effects of Korean ginseng root extract on cisplatin-induced emesis in a rat-pica model.
In the present study, we investigate the effect of Korean ginseng root extract (KG) on cisplatin-induced pica in a rat model. Rats were treated with KG before (25, 50, and 100 mg/kg) or after (12.5, 25, and 50 mg/kg) a single intraperitoneal injection of cisplatin (7 and 6 mg/kg, respectively). We examined intake of kaolin and normal food as an indicator of the emetic stimulus every 24 h for 120 h. Changes in body weight, haematology and histopathology were additionally assessed. Pre-treatment with KG (25 and 50 mg/kg) significantly attenuated cisplatin-induced kaolin intake (24, 48, and 72 h) and markedly improved intake of normal food by rats at 48, 72, 96, and 120 h. Cisplatin-induced kaolin intake was markedly decreased upon post-treatment of rats with KG (12.5, 25, and 50 mg/kg) at 24 h. Notably, post-treatment with the lowest KG dose resulted in a significant anti-pica effect and improved food intake until 72 h. The magnitude of body weight reduction was significantly diminished in rats pre-treated/post-treated with 25, 50, and 12.5 mg/kg KG. The anti-pica effects of KG were further confirmed with haematological and histopathological findings. Our findings collectively indicate that KG improves the resistance of rats against emesis.
Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Daejeon, Republic of Korea.
Hanumantha Rao Balaji
HR
Raghavendran
Sathyanath
S
Rekha
Jang-Woo
JW
Shin
Hyeong-Geug
HG
Kim
Jing-Hua
JH
Wang
Hye-Jung
HJ
Park
Min-Kyung
MK
Choi
Jung-Hyo
JH
Cho
Chang-Gue
CG
Son
D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D005894:Panax / Q000737:chemistry*; D010842:Pica / Q000503:physiopathology*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D000970:Antineoplastic Agents; D010936:Plant Extracts; D002945:Cisplatin