Parametric uncertainties and influence of the dead volume representation in modelling simulated moving bed separation processes.
In this study, a systematic numerical procedure for identifying the model parameters of simulated moving bed (SMB) separation processes is developed. The parameters are first estimated by minimizing a weighted least-squares criterion using experimental data from batch experiments, e.g. the time evolution of the concentration of elution peaks. Then, a cross-validation is achieved using data from experiments in SMB operation. At this stage, the importance of a careful modelling of the dead volumes within the SMB process is highlighted. In addition, confidence intervals on the estimated parameters and on the predicted concentration profiles are evaluated.
Service d'Automatique et d'Analyse des Systèmes, Université Libre de Bruxelles, CP 165/55, 50, Av. F. D. Roosevelt, B-1050 Brussels, Belgium.
V
V
Grosfils
R
R
Hanus
A Vande
AV
Wouwer
M
M
Kinnaert
D002845:Chromatography / Q000295:instrumentation*; D008962:Models, Theoretical; D012117:Resins, Synthetic / Q000737:chemistry
D012117:Resins, Synthetic