¹⁸F-FDG and ¹¹C-MET positron emission tomography findings of cutaneous mast cell tumor in a dog.
A 12-year-old intact male Maltese dog presented with an inguinal mass. Histopathology revealed a grade III mast cell tumor. Computed tomography demonstrated pulmonary and inguinal nodules and masses. Chemotherapy was performed using a vinblastine/prednisone protocol, and the inguinal mass disappeared 5 weeks later. Use of 2-deoxy-2-[¹⁸F]fluoro-D-glucose (¹⁸F-FDG) and (L)-[methyl- ¹¹C]methionine (¹¹C-MET)-positron emission tomography (PET) demonstrated hypermetabolic areas in the lungs and inguinal region one week after initial chemotherapy. The standardized uptake values of ¹⁸F-FDG were not different between lung and inguinal lesions; however, the inguinal lesion had a higher ¹¹C-MET standardized uptake value than the lung lesions. The hypermetabolic area was still visible on the second ¹⁸F-FDG-PET scan despite the disappearance of the mass. This is the first report of ¹¹C-MET-PET findings associated with a cutaneous mast cell tumor in a dog.
Cerebral Microcirculation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Byeong-Teck
BT
Kang
Min-Hee
MH
Kang
Chae-Young
CY
Lim
Dae-Young
DY
Kim
Hee-Myung
HM
Park
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology*; D008297:Male; D034801:Mastocytoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008715:Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D049268:Positron-Emission Tomography / Q000662:veterinary*; D019275:Radiopharmaceuticals / Q000494:pharmacology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine; C038344:methionine methyl ester