A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma--a case report with EGFR copy number analysis.
BACKGROUND
Small cell neuroendocrine carcinoma (SNEC) of maxillary sinus is a rare and aggressive malignancy. A tumor with squamous cell carcinoma, adenocarcinoma and SNEC co-existence is extremely rare.


METHODS
We present a colliding tumor of squamous cell, adenocarcinoma and SNEC in maxillary sinus. The clinical features, diagnosis and EGFR flourescence in situ hybridization (FISH) study are presented. A 52-year-old female had a 1-month history of progressing left cheek swelling and purulent rhinorrhea. Magnetic resonance imaging showed a tumor involving left maxilla and orbital floor. Excision of tumor was done and the defect was reconstructed with free flap. The pathology revealed a malignant tumor composed of squamous cell carcinoma, adenocarcinoma and SNEC components. EGFR FISH study showed no gene amplification in 3 components of this tumor. The tumor progressed rapidly and the patient expired at 8 months after surgery.


CONCLUSIONS
A colliding tumor of squamous cell, adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor.
Huang
Shiang-Fu
SF
Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan. bigmac@adm.cgmh.org.tww
Chuang
Wen-Yu
WY
Cheng
Sou-De
SD
Hsin
Li-Jen
LJ
Lee
Li-Yu
LY
Kao
Huang-Kai
HK
D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged
D004273:DNA, Neoplasm; D066246:ErbB Receptors