Association of novelty seeking scores and striatal dopamine D₂/D₃ receptor availability of healthy volunteers: single photon emission computed tomography with ¹²³i-iodobenzamide.
It has been speculated that novelty seeking (NS) behavior is related to the dopaminergic system. Fifty-two subjects completed the Tridimensional Personality Questionnaire and underwent single photon emission computed tomography with (123)I-iodobenzamide. A marginally positive correlation was noted between NS and striatal dopamine D(2)/D(3) receptor availability (r = 0.25, p =0.07). A positive association was noted between the NS scores and left striatal D(2)/D(3) receptor availability (r= 0.29, p =0.04). The results suggest that a relationship might exist between NS score and dopaminergic activity.
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tainan Municipal Hospital, 138 Shen Li Road, Tainan, Taiwan.
Hsiang Yu
HY
Huang
I Hui
IH
Lee
Kao Ching
KC
Chen
Tzung Lieh
TL
Yeh
Po See
PS
Chen
Yen Kuang
YK
Yang
Nan-Tsing
NT
Chiu
We Jen
WJ
Yao
Chia-Chieh
CC
Chen
D000328:Adult; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D010555:Personality Inventory; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D011795:Surveys and Questionnaires; D013624:Taiwan; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult
D007462:Iodobenzenes; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C426805:idobenzamide