N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties.
We report on the neuroprotective effects of N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) in a model of oxidative stress-induced nerve cell death using mouse hippocampal-derived HT22 cells. The four derivatives (JLK1472, JLK1486, JLK1522 and JLK1535) protected the HT22 cells from death at concentrations ranging from 0.1 to 1 μM. Their action is partially dependent on their ability to act as PPARγ agonists. These analogues also maintain GSH levels suggesting that they have indirect anti-oxidant effects.
Laboratoire de Chimie Biomoléculaire, CNRS, IBDML-UMR-6216, Université de la Méditerranée, Marseille, France.
Sébastien
S
Madonna
Pamela
P
Maher
Jean-Louis
JL
Kraus
D000588:Amines / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D006624:Hippocampus / Q000166:cytology; D051379:Mice; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D015125:Oxyquinoline / Q000737:chemistry* / Q000494:pharmacology; D047495:PPAR gamma / Q000819:agonists*
D000588:Amines; D000975:Antioxidants; D018696:Neuroprotective Agents; D047495:PPAR gamma; D015125:Oxyquinoline