Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta.
Chronic histiocytic intervillositis of the placenta (CHI) is a rare and poorly understood pathology which may occur in all trimesters. The most conspicuous feature is a histiocytic infiltration of the intervillous space without involvement of the villous parenchyma. In this report on CHI, we re-evaluate a series of four cases and focus on histological, immunohistological and fluorescence in situ hybridisation-derived findings, fetal status and clinical data for previously unrecognised CHI-associated features. Our approach revealed that assisted reproduction-induced pregnancy had been performed in 2 of 4 CHI cases, but other factors and comorbidities are likely to contribute to CHI.
Institute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, Germany.
J
J
Traeder
D
D
Jonigk
H
H
Feist
V
V
Bröcker
F
F
Länger
H
H
Kreipe
K
K
Hussein
D000328:Adult; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000453:epidemiology / Q000473:pathology*; D011247:Pregnancy; D012189:Retrospective Studies