Seven new monoterpenoid indole alkaloids from Gelsemium elegans.
Seven new indole alkaloids were isolated from the roots of Gelsemium elegans Benth. and their structures were determined by spectroscopic analysis and chemical transformation from known alkaloids. Kounaminal (1) is a new koumine-type alkaloid that contains an unusual aminal moiety. Humantenoxenine (2) and 15-hydroxyhumantenoxenine (3) are humantenine-type alkaloids that contain a novel β-amino-α,β-unsaturated ketone residue. The other four novel alkaloids are two gelsedilam-related and two gelsenicine-related alkaloids.
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Yousuke
Y
Yamada
Mariko
M
Kitajima
Noriyuki
N
Kogure
Sumphan
S
Wongseripipatana
Hiromitsu
H
Takayama
D031450:Gelsemium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry* / Q000145:classification*
D046948:Secologanin Tryptamine Alkaloids