NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse.
Recent study shows that NT69L, an analog of neurotensin (NT) (8-13), reduces ethanol consumption and preference in mice through modulation of neurotensin receptor subtype one. The current study showed that NT69L significantly decreased ethanol-induced increase of dopamine and glutamate levels in striatum of mouse. These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction.
Li
Zhimin
Z
Neuroscience Laboratory and Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. li.zhimin@mayo.edu
Boules
Mona
M
Richelson
Elliott
E
D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000096:biosynthesis*; D000431:Ethanol / Q000494:pharmacology*; D018698:Glutamic Acid / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017551:Microdialysis; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*
D002492:Central Nervous System Depressants; D010446:Peptide Fragments; C407426:neurotensin 69L; D009496:Neurotensin; D000431:Ethanol; D018698:Glutamic Acid; D004298:Dopamine