Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism.
Hyperthyroidism causes a variety of adverse effects on the cardiovascular system. Left ventricular (LV) asynchrony is defined as loss of the simultaneous peak contraction of corresponding cardiac segments. The aim of this study was to assess systolic asynchrony in patients with overt hyperthyroidism. Asynchrony was evaluated in 27 patients with overt hyperthyroidism and 21 controls. All the patients and controls were subjected to a tissue synchronization imaging (TSI). The time to regional peak systolic tissue velocity (Ts) in LV by the six-basal-six-mid-segmental model was measured on ejection phase TSI images and four TSI parameters of systolic asynchrony were computed. All TSI parameters of LV asynchrony increased in hyperthyroid patients compared to controls: the standard deviation (SD) of the 12 LV segments Ts (35.7±14.4 vs 20.1±10.1, P<0.0001); the maximal difference in Ts between any 2 of the 12 LV segments (111.9±40.7 vs 65.9±30.7, P<0.0001); the SD of the 6 basal LV segments (31.2±18.2 vs 16.8±9.7, P=0.01); and the maximal difference in Ts between any 2 of the 6 basal LV segments (76.6±42.0 vs 44.4±25.7, P=0.005). Patients with overt hyperthyroidism present evidence of LV asynchrony by TSI.
Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, and Department of Internal Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. akiris79@yahoo.com
Abdulkadir
A
Kırış
Cihangir
C
Erem
Gülhanım
G
Kırış
Mustafa
M
Koçak
Omer
O
Gedikli
Irfan
I
Nuhoğlu
Merih
M
Kutlu
Tuba
T
Kaplan
Mustafa
M
Gökçe
Sükrü
S
Celik
D000208:Acute Disease; D000328:Adult; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013599:Systole / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*