SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.
SIV-infected natural hosts do not progress to clinical AIDS yet display high viral replication and an acute immunologic response similar to pathogenic SIV/HIV infections. During chronic SIV infection, natural hosts suppress their immune activation, whereas pathogenic hosts display a highly activated immune state. Here, we review natural host SIV infections with an emphasis on specific immune cells and their contribution to the transition from the acute-to-chronic phases of infection.
Seattle Biomedical Research Institute, Seattle, WA, USA.
Kiran D
KD
Mir
Melanie A
MA
Gasper
Vasudha
V
Sundaravaradan
Donald L
DL
Sodora
D000208:Acute Disease; D000818:Animals; D016923:Cell Death / Q000276:immunology*; D015658:HIV Infections; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008213:Lymphocyte Activation / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*