Usage of analgesic in a murine model infected latently with pseudorabies virus.
Butorphanol tartrate (BT) was injected into mice before injection with acetylcholine in a murine model infected latently with pseudorabies virus. The analgesic effect and its influence on virus reactivation were observed. Mice preinjected with BT showed suppression of screaming, moving and excitation and the same level of movement after excitation as mice injected with PBS. In the group injected with BT i.p., one mouse died and another developed diarrhea with increased virus excretion. These results showed that BT has analgesic effects by both injection routes, s.c. and i.p.; however, BT induced death as a side effect, especially with i.p. injection. The injection route for BT should therefore be investigated further.
Tanaka
Seiichi
S
Division of Laboratory Animal Sciences, Research Promotion Project, Oita University, Hasama, Yufu, Oita. denchu@oita-u.ac.jp
Mannen
Kazuaki
K
D000109:Acetylcholine / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D002077:Butorphanol / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D011558:Herpesvirus 1, Suid / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011557:Pseudorabies / Q000821:virology*; D013312:Stress, Physiological / Q000187:drug effects; D014775:Virus Activation
D000701:Analgesics, Opioid; D000109:Acetylcholine; D002077:Butorphanol