Divergence, not diversity of an attenuated equine lentivirus vaccine strain correlates with protection from disease.
We recently reported an attenuated EIAV vaccine study that directly examined the effect of lentiviral envelope sequence variation on vaccine efficacy. The study [1] demonstrated for the first time the failure of an ancestral vaccine to protect and revealed a significant, inverse, linear relationship between envelope divergence and protection from disease. In the current study we examine in detail the evolution of the attenuated vaccine strain utilized in this previous study. We demonstrate here that the attenuated strain progressively evolved during the six-month pre-challenge period and that the observed protection from disease was significantly associated with divergence from the original vaccine strain.
Craigo
Jodi K
JK
Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Barnes
Shannon
S
Cook
Sheila J
SJ
Issel
Charles J
CJ
Montelaro
Ronald C
RC
D000818:Animals; D016000:Cluster Analysis; D004859:Equine Infectious Anemia / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D019143:Evolution, Molecular; D005260:Female; D006734:Horse Diseases / Q000276:immunology / Q000517:prevention & control*; D006736:Horses; D004860:Infectious Anemia Virus, Equine / Q000235:genetics / Q000276:immunology*; D008297:Male; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology*
D012367:RNA, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines