Etiological characteristics of people with intellectual disability in Iran.
OBJECTIVE
To describe the etiological characteristics of intellectual disability in one Iranian center.


METHODS
In a cross-sectional study, 64 cases with mental retardation (MR) were examined in the Intellectual Rehabilitation & Welfare Care Center of Vardavard, Iran between April and September 2008. Cases were diagnosed with MR or showed delay/regression of developmental milestones. We studied the records of patients and interviewed their families.


RESULTS
A total of 64 cases were screened (most were children). The number of male patients was 19 (29.7%) and the females was 45 (70.3%). First degree relatives with mental retardation were found in the families of studied patients, among these relatives 48% were female and 52% were male. Up to 77% of the marriages were between relatives, approximately half between first cousins. The illiteracy rate reached 34% in the families of MR children. Hard labor, hypoxia during labor, mother`s preexisting systemic disease, and maternal and neonatal infection were the most important factors for MR. Furthermore, most of the families were found to have low socioeconomic class.


CONCLUSIONS
Cognitive disabilities in children are multifactorial. Consanguinity was the main risk factor for MR and considering its high rate in our country due to traditional marriages, it should be modified.
Jazayeri
Roshanak
R
Department of Genetics, University of Social Welfare and Rehabilitation Sciences, PO Box 13185-1678, Tehran, Iran. swt_f@yahoo.com
Saberi
Seyed H
SH
Soleymanzadeh
Maryam
M
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005192:Family Health; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology*; D007361:Intelligence Tests; D007492:Iran / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D055815:Young Adult