title: Early enteral fat supplementation with microlipid® and fish oil in the treatment of two premature infants with short bowel.
abstract: The infusion of Intralipid® is a main risk factor for parenteral nutrition-associated cholestasis in infants with short bowel syndrome. Early provision of enteral fat to reduce the use of Intralipid while providing adequate fat for the growth of infants with short bowel has not been reported. We present 2 cases of premature infants with short bowel who received early supplementation of enteral Microlipid® and fish oil. This approach allowed us to discontinue Intralipid shortly after initiating feedings. The infants tolerated Microlipid/fish oil well without adverse reactions, had appropriate weight gain and ostomy output. They underwent bowel reanastomosis 3 weeks after enteral feeding began, and were discharged on full oral feedings. In case 1, the infant did not develop parenteral nutrition-associated cholestasis; in case 2, cholestasis had developed before initiating feeds, but was not aggravated by enteral fat and was improving prior to discharge.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. qyang @ wfubmc.edu
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Cherrie D
authors.initials: CD
authors.lastname: Welch
authors.forename: Kathleen
authors.initials: K
authors.lastname: Ayers
authors.forename: Charles
authors.initials: C
authors.lastname: Turner
authors.forename: Thomas
authors.initials: T
authors.lastname: Pranikoff
mesh_terms: D002779:Cholestasis / Q000209:etiology / Q000517:prevention & control; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004750:Enteral Nutrition; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D012778:Short Bowel Syndrome / Q000628:therapy*; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils