title: Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions.
abstract: A highly efficient enantioselective S(N)Ar reaction of chiral acyl bicyclic lactam with substituted-2,4-dinitrobenzenes was developed, affording products containing quarternary stereogenic centers. They are further utilized towards an enantioselective synthesis of spirooxoindoles.
authors.affiliation: Medicinal Chemistry Department, GVK Biosciences, Plot 28A, IDA Nacharam, Hyderabad, India. Subhabrata.sen@gvkbio.com
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Sen
authors.forename: Venkata R
authors.initials: VR
authors.lastname: Potti
authors.forename: Ramu
authors.initials: R
authors.lastname: Surakanti
authors.forename: Y L N
authors.initials: YL
authors.lastname: Murthy
authors.forename: Raghavaiah
authors.initials: R
authors.lastname: Pallepogu
mesh_terms: D000215:Acylation; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis*; D007769:Lactams / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; D007211:Indoles; D007769:Lactams; D013141:Spiro Compounds