title: [The transcript expression of PKC-β₁ gene in human lung cancer].
abstract: BACKGROUND
  To determine the relationship between the transcript expression of PKC-β₁ gene and pathophysilogical characteristics of lung cancer.
  
  
  METHODS
  The expression of PKC-β₁ mRNA was detected in 50 human lung cancer tissues,para-cancerous tissues,non-cancerous tissues and 30 benign pulmonary lession tissues by Northern blot.
  
  
  RESULTS
  (1) The expression level of PKC-β₁ mRNA in lung cancer tissues was significantly higher than that in para-cancerous tissues,non-cancerous tissues and benign pulmonary lession tissues (P<0.01).(2) The expression level of PKC-β₁ in poor-differentiated cancer was significantly higher than that in moderate-well differentiated cancer (P<0.05).(3) The expression of PKC-β₁ mRNA in stage III cancer was remarkably higher than that in stage I and stage II disease (P<0.01).(4) The expression of PKC-β₁ in cancer with lymph node metastasis was significantly higher than that in the cancer without lymph node involvement (P<0.01).
  
  
  CONCLUSIONS
  There is an overexpression of PKC-β₁ mRNA in lung cancer tissues,and it may play an important role in the advancement,cancer cell differentiation and metastasis of lung cancer.
authors.affiliation: Cancer Center,The First University Hospital,West China University of Medical Sciences,Chengdu,Sichuan 610041,P.R.China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Yang