Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems.
DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have revealed a complexity beyond that initially expected, with inter- and intrapathway complementation as well as functional interactions between proteins involved in repair pathways. In this paper we give a broad overview of the whole DNA repair system and focus on the molecular basis of the repair machineries, particularly in Thermus thermophilus HB8.
Morita
Rihito
R
Department of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan.
Nakane
Shuhei
S
Shimada
Atsuhiro
A
Inoue
Masao
M
Iino
Hitoshi
H
Wakamatsu
Taisuke
T
Fukui
Kenji
K
Nakagawa
Noriko
N
Masui
Ryoji
R
Kuramitsu
Seiki
S