Altered gentamicin serum concentrations in obese pediatric patients.
We performed a retrospective case-cohort study of 50 obese pediatric patients aged 2 to 18 years who received scheduled gentamicin therapy, with serum peak and trough concentrations measured. Obese pediatric patients had significantly higher gentamicin serum peak and trough concentrations despite receiving significantly lower mg/kg of actual body weight doses of gentamicin.
Choi
Jamie J
JJ
Department of Pharmacy, Texas Children's Hospital, Houston, TX, USA. jachoi@texaschildrens.org.
Moffett
Brady S
BS
McDade
Erin J
EJ
Palazzi
Debra L
DL
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D012189:Retrospective Studies; D044967:Serum / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D005839:Gentamicins