[The correlation between combining 1p/19q LOH and pathology in gliomas].
OBJECTIVE
To investigate the frequencies of combining loss of heterozygosity (LOH) of chromosome 1p/19q in gliomas of different pathologies and analyze the clinical factors correlated with combining LOH by logistic regression.


METHODS
Tumor samples from 127 glioma patients were collected. The status of 1p and 19q was evaluated by fluorescence in situ hybridization (FISH) and the frequencies of combining 1p/19q LOH in gliomas of different pathologies were analyzed.


RESULTS
The frequencies of combining 1p/19q LOH in astrocytic, oligoastrocytic and oligodendroglial tumors were 19.30%, 50.00% and 80.77% respectively. The frequencies of combining 1p/19q LOH in oligoastrocytic and oligodendroglial tumors were higher than those in astrocytic tumors (P < 0.01) and the frequencies of combining 1p/19q LOH in oligodendroglial tumors was higher than those in oligoastrocytic tumors (P < 0.05). The frequencies of 1p/19q LOH in astrocytic, oligoastrocytic and oligodendroglial tumors were 12.28%, 11.36 and 0 respectively. There was no significant correlation between combining 1p/19q LOH and age, gender and grade by logistic regression.


CONCLUSIONS
In gliomas, combining 1p/19q LOH is proved to be the most common pattern of chromosome deletion involving 1p or 19q. It is significantly correlated with oligodendroglial component. Combining 1p/19q LOH may be valuable in the diagnosis, treatment and prognostic prediction for glioma with oligodendroglial component.
Ren
Xiao-hui
XH
Beijing Neurosurgical Institute, Beijing 100050, China.
Cui
Xiang-li
XL
Lin
Song
S
Wang
Zhong-cheng
ZC
D000293:Adolescent; D000328:Adult; D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D009836:Oligodendroglia / Q000473:pathology; D009837:Oligodendroglioma / Q000235:genetics / Q000473:pathology; D055815:Young Adult