Preparation, characterization and in vitro testing of poly(lactic-co-glycolic) acid/barium titanate nanoparticle composites for enhanced cellular proliferation.
The recent advancements in tissue engineering and, more in general, in cell-based applications, has led to an ever increasing interest toward new materials for sustained cell proliferation and differentiation. Here, the preparation and the characterization of scaffolds based on poly(lactic-co-glycolic) acid / barium titanate nanoparticle composites are presented. In vitro testing on H9C2 cell line demonstrates how the presence of the nanoparticles positively affects both the proliferation and the differentiation of this muscle-like cell line. Finally, the possibility to obtain porous scaffold and, therefore, an actual 3D culture system, is introduced.
Ciofani
Gianni
G
Italian Institute of Technology, Smart Materials Lab, Center for Micro-BioRobotics c/o Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, Pontedera, Pisa, Italy. g.ciofani@sssup.it
Ricotti
Leonardo
L
Mattoli
Virgilio
V
D000818:Animals; D017609:Barium Compounds / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D048091:Guided Tissue Regeneration; D019344:Lactic Acid / Q000737:chemistry* / Q000494:pharmacology*; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000494:pharmacology*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D051381:Rats; D013499:Surface Properties; D013718:Tensile Strength; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D017609:Barium Compounds; C024547:barium titanate(IV); D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014025:Titanium