[The transcript expression of PKC-β₁ gene in human lung cancer].
BACKGROUND
To determine the relationship between the transcript expression of PKC-β₁ gene and pathophysilogical characteristics of lung cancer.


METHODS
The expression of PKC-β₁ mRNA was detected in 50 human lung cancer tissues,para-cancerous tissues,non-cancerous tissues and 30 benign pulmonary lession tissues by Northern blot.


RESULTS
(1) The expression level of PKC-β₁ mRNA in lung cancer tissues was significantly higher than that in para-cancerous tissues,non-cancerous tissues and benign pulmonary lession tissues (P<0.01).(2) The expression level of PKC-β₁ in poor-differentiated cancer was significantly higher than that in moderate-well differentiated cancer (P<0.05).(3) The expression of PKC-β₁ mRNA in stage III cancer was remarkably higher than that in stage I and stage II disease (P<0.01).(4) The expression of PKC-β₁ in cancer with lymph node metastasis was significantly higher than that in the cancer without lymph node involvement (P<0.01).


CONCLUSIONS
There is an overexpression of PKC-β₁ mRNA in lung cancer tissues,and it may play an important role in the advancement,cancer cell differentiation and metastasis of lung cancer.
Zhou
Q
Q
Cancer Center,The First University Hospital,West China University of Medical Sciences,Chengdu,Sichuan 610041,P.R.China.
Liu
L
L
Li
L
L
Wang
Y
Y
Chen
J
J
Yang
J
J