Mixed-strain Mycobacterium tuberculosis infections among patients dying in a hospital in KwaZulu-Natal, South Africa.
We performed spoligotyping and 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing on M. tuberculosis culture-positive biopsy specimens collected from adults dying in a hospital in KwaZulu-Natal. Of 56 culture-positive samples genotyped, we detected mixed strains in five (9%) and clonal heterogeneity in an additional four (7%).
Cohen
Ted
T
Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA 02115, USA. tcohen@hsph.harvard.edu
Wilson
Douglas
D
Wallengren
Kristina
K
Samuel
Elizabeth Y
EY
Murray
Megan
M
D000328:Adult; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D008297:Male; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D013019:South Africa; D014376:Tuberculosis / Q000382:microbiology* / Q000401:mortality*
D004269:DNA, Bacterial