Antiplasmodial activity of three bisbenzylisoquinoline alkaloids from the tuber of Stephania rotunda.
Three bisbenzylisoquinoline alkaloids were isolated for the first time from Stephania rotunda tuber. Their structures were elucidated by spectroscopic methods and their antiplasmodial activity was investigated in vitro on chloroquine resistant Plasmodium falciparum strain W2. These alkaloids were identified as 2-norcepharanthine (1), cepharanoline (2) and fangchinoline (3). In vitro, they displayed significant antiplasmodial activity with inhibitory concentration 50 values of 0.3, 0.2 and 0.3 µM.
Chea
Aun
A
Laboratory of Ethnopharmacology and Pharmacognosy, UMR-MD3, Faculty of Pharmacy, University of the Mediterranean Aix-Marseille II, Marseille, France.
Bun
Sok-Siya
SS
Azas
Nadine
N
Gasquet
Monique
M
Bory
Sothavireak
S
Ollivier
Evelyne
E
Elias
Riad
R
D000962:Antimalarials / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044182:Benzylisoquinolines / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002160:Cambodia; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035281:Plant Tubers / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D031607:Stephania / Q000737:chemistry*
D000962:Antimalarials; D044182:Benzylisoquinolines; C060802:fangchinoline