title: [Prognostic value of inflammatory markers and lipid profile in patients suffering from intermittent claudication - a pilot study].
abstract: OBJECTIVE
  To analyse clinical and serological variables (lipid profile, inflammatory biomarkers) as potential risk factors for the development of short-term cardiovascular events and mortality in patients suffering from intermittent claudication.
  
  
  METHODS
  We included all patients with a first-time diagnosis of vascular intermittent claudication in our center during 2005-2006. We analysed clinical data, serological parameters (creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, ApolipoproteinA1, ApolipoproteinB100, lipoprotein(a), homocysteine, C-reactive protein, erythrocyte sedimentation rate [ESR], fibrinogen), cardiovascular events and mortality during 1-3 year follow-up.
  
  
  RESULTS
  We included 162 patients: 143 (88.3%) men, mean (SD) age 66 (10.4) (41-86) years, 76 (46.9%) active smokers, 96 (59.3%) hypertensive, 56 (34.6%) diabetic, 129 (79.6%) hypercholesterolemic. We registered 16 (9.9%) coronary/cerebrovascular events, 18 (11.1%) lower limb vascular events and 9 (5.9%) late deaths during follow-up (mean [SD] 18.2 [8] months). Hypertension was the only predictor of coronary or cerebrovascular events (p=0.013); heart disease and HDL-cholesterol<45 mg/dL were independent risk factors for lower limb vascular events (p=0.021 and 0.049), and ESR>20 mm/h was associated with all-cause death (p=0.008).
  
  
  CONCLUSIONS
  Reduced HDL-cholesterol and elevated ESR have emerged as independent risk factors for short-term lower limb vascular events and death.
authors.affiliation: Servicio de Angiología y Cirugía Vascular, Hospital de Galdakao-Usansolo, Bizkaia, España. melina.vegadeceniga@osakidetza.net
authors.forename: Melina
authors.initials: M
authors.lastname: Vega de Céniga
authors.forename: Luis
authors.initials: L
authors.lastname: Estallo
authors.forename: Margarita Esteban
authors.initials: ME
authors.lastname: Salan
authors.forename: Esther
authors.initials: E
authors.lastname: Bravo
authors.forename: Maite
authors.initials: M
authors.lastname: Izagirre
authors.forename: Angel
authors.initials: A
authors.lastname: Barba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007383:Intermittent Claudication / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D015415:Biomarkers
vernacular_title: Valor pronóstico de marcadores inflamatorios y perfil lipídico en pacientes con claudicación intermitente. Estudio piloto.