title: [The clinico-pathological manifestation of cardiac involvement in eosinophilic diseases].
abstract: OBJECTIVE
  To investigate the clinical and pathological features of eosinophilic diseases with cardiac involvement.
  
  
  METHODS
  We analyzed the clinical and cardiac pathological data of 7 patients with eosinophilic diseases with cardiac involvement under endomyocardial biopsy or autopsy.
  
  
  RESULTS
  Seven patients (5 male, average age 51 years) were enrolled. Four patients were diagnosed as idiopathic hypereosinophilic syndrome and three were Churg-Strauss syndrome. Peripheral blood eosinophilia count increased significantly in all patients. Cardiac involvement included angina pectoris, myocardial infarction, heart failure, presyncope and sudden death. Electrocardiogram showed cardiac ischemia, bundle branch block and third degree atrioventricular block. Echocardiography suggested ventricular and atrial enlargement, decreased ventricular systolic function, pulmonary hypertension, valvular prolapse and insufficiency and endocarditis. Pathology displayed infiltration of eosinophils, formation of granulomata, necrotizing vasculitis, myocardial necrosis and endomyocardial fibrosis in heart. Coronary artery could be also affected and led to myocardial infarction.
  
  
  CONCLUSIONS
  Cardiovascular complications of eosinophilic diseases are a major source of morbidity and mortality in these disorders. The manifestations are multiple and early recognition and treatment with steroid and immunosuppressant can improve prognosis.
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Tian
authors.forename: Quan
authors.initials: Q
authors.lastname: Fang
authors.forename: Da-chun
authors.initials: DC
authors.lastname: Zhao
authors.forename: Quan-cai
authors.initials: QC
authors.lastname: Cui
authors.forename: Yong-tai
authors.initials: YT
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Meng-tao
authors.initials: MT
authors.lastname: Li
authors.forename: Xiu-chun
authors.initials: XC
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D004699:Endocardium / Q000473:pathology; D004802:Eosinophilia / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011379:Prognosis