Isolation of Cryptococcus magnus and Cryptococcus chernovii from nasal cavities of pediatric patients with acute lymphoblastic leukemia.
We report the isolation of Cryptococcus magnus and Cryptococcus chernovii in cultures inoculated with nasal specimens of pediatric cancer patients with acute lymphoblastic leukemia. The phenotypic characteristics of the isolates are described and their identity confirmed by sequencing of rDNA. Both species were resistant to caspofungin, anidulafungin, 5-flucytosine and itraconazole, but susceptible to amphotericin B, posaconazole and voriconazole. To the best of our knowledge, the isolation of these two species from nasal cavities has not been reported previously.
Khan
Ziauddin
Z
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait-13110. zkhan@hsc.edu.kw
Mokaddas
Eiman
E
Ahmad
Suhail
S
Burhamah
Mona H A
MH
D000935:Antifungal Agents / Q000494:pharmacology; D002467:Cell Nucleus / Q000235:genetics; D002648:Child; D003454:Cryptococcus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D004271:DNA, Fungal / Q000235:genetics; D025141:Drug Resistance, Fungal; D006801:Humans; D008297:Male; D009181:Mycoses / Q000382:microbiology; D009668:Nose Diseases / Q000382:microbiology*; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000382:microbiology*
D000935:Antifungal Agents; D004271:DNA, Fungal