title: Role of microRNAs in cardiac preconditioning.
abstract: Preconditioning (PC) of the heart by sublethal ischemia, mild heat shock, or hypoxia has evolved as a powerful experimental tool to discover novel signaling mechanisms in cardioprotection. The ultimate goal is to determine novel therapeutic targets for potential application in humans to protect the heart against ischemia-related injuries. In recent years, there has been a tremendous interest in understanding the role of small noncoding RNAs, microRNAs (miRs), in cardiovascular diseases. miRs have been recognized as regulators of gene expression by destabilization and translational inhibition of target messenger RNAs. Studies have shown that several miRs, including miR-1, miR-133, miR-21, miR-126, miR-320, miR-92a, and miR-199a, are regulated after preconditioning and play an active role in protecting the heart against ischemia/reperfusion injury. These miRs also drive the synthesis of important cardioprotective proteins including heat shock protein (HSP)-70, endothelial nitric oxide synthase, inducible nitric oxide synthase, HSP-20, Sirt1, and hypoxia-inducible factor 1a. We believe that identification and targeted delivery of miR(s) in the heart could have an immense therapeutic potential in reducing myocardial infarction in patients suffering from heart disease.
authors.affiliation: Division of Cardiology, Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, 1101 East Marshall St, Richmond, VA 23298, USA.
authors.forename: Fadi N
authors.initials: FN
authors.lastname: Salloum
authors.forename: Chang
authors.initials: C
authors.lastname: Yin
authors.forename: Rakesh C
authors.initials: RC
authors.lastname: Kukreja
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods* / Q000639:trends; D035683:MicroRNAs / Q000502:physiology* / Q000627:therapeutic use; D015428:Myocardial Reperfusion Injury / Q000235:genetics / Q000517:prevention & control*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000517:prevention & control
chemical_list: D035683:MicroRNAs