[Correlation of microsatellite alterations on chromosome 9 and oncogenesis,metastasis in NSCLC].
BACKGROUND
To investigate the relationship among microsatellite alterations on chromosome 9(9p) and the oncogenesis,metastasis of non-small cell lung cancer (NSCLC).


METHODS
Two microsatellite markers,IFNA and D9S171,were analyzed in 32 cases of NSCLC by polymerase chain reaction-based silver-staining assay.


RESULTS
Of 32 cases of NSCLC,14(43.8%) had microsatellite alterations.The alteration frequency was 64.7% in NSCLC with lymph node metastasis,and 20% in those without lymph node metastasis.There was significant difference between the two groups.None of benign lung tissues showed microsatellite alterations.


CONCLUSIONS
Microsatellite alteration on chromosome 9p in NSCLC appears to be a common and specific event,and may be a valuable molecular marker for determination of early diagnosis and metastasis of NSCLC.
Zhang
S
S
Laboratory of Molecular Biology,Henan Provincial Chest Hospital,Zhengzhou,Henan 450003,P.R.China.
Tang
B
B
Liang
Q
Q
Li
S
S
He
Y
Y
Yang
L
L