[Stroke volume variation in the evaluation of fluid responsiveness in refractory septic shock].
OBJECTIVE
To evaluate fluid responsiveness by stroke volume variation(SVV) in mechanically ventilated patients with refractory septic shock.


METHODS
Forty-two refractory septic shock patients were enrolled in the study. According to the responsiveness of fluid loading, the patients were divided into responsive group and non-responsive group. The SVV values of two groups were retrospectively analyzed. The receiver operating characteristic curve was drafted to determine the cut-off value of SVV for predicting fluid responsiveness.


RESULTS
Among the 42 refractory septic shock patients, 24 were found responsive to fluid loading, 18 were not; before the fluid loading, central venous pressure, heart rate, mean arterial pressure and global end-diastolic volume index in the both groups showed no significant differences whereas the SVV in the responsive group was much higher than that in the nonresponsive group (P=0.006). Using SVV≥12% as the threshold to predict fluid responsiveness, the sensitivity was 77%, specificity was 85%.


CONCLUSIONS
SVV can accurately predict fluid responsiveness in refractory septic shock patients.
Zhang
Hong-min
HM
Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Liu
Da-wei
DW
Wang
Xiao-ting
XT
Rui
Xi
X
Wang
Hao
H
He
Huai-wu
HW
Liu
Ye
Y
Chen
Xiu-kai
XK
D000328:Adult; D000368:Aged; D002496:Central Venous Pressure; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012772:Shock, Septic / Q000503:physiopathology*; D013318:Stroke Volume