title: Untreated type 2 diabetes and its complications are associated with subcortical infarctions.
abstract: OBJECTIVE
  To investigate the association of type 2 diabetes with subcortical infarctions.
  
  
  METHODS
  We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging.
  
  
  RESULTS
  The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11-6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects.
  
  
  CONCLUSIONS
  These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. roberts.rosebud@mayo.edu
authors.forename: Rosebud O
authors.initials: RO
authors.lastname: Roberts
authors.forename: Kejal
authors.initials: K
authors.lastname: Kantarci
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Scott A
authors.initials: SA
authors.lastname: Przybelski
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Weigand
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000453:epidemiology* / Q000209:etiology; D048909:Diabetes Complications / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male