title: [Cervical intraepithelial neoplasia 2+ in low-grade squamous intraepithelial lesion pathologically diagnosed by colposcopy-assisted biopsy].
abstract: OBJECTIVE
  To assess the accuracy of colposcopy-assisted biopsy for the diagnosis of cervical intraepithelial neoplasia I (CIN(1)) and to reappraise the correlative factors of missed CIN(2+) in low-grade SIL(squamous intraepithelial lesion)pathologically diagnosed by colposcopy-assisted biopsy.
  
  
  METHODS
  A total of 274 women with CIN(1) diagnosed by colposcopy-assisted biopsy and missing scheduled follow-up thus elected to undergo loop electrosurgical excisional procedure (LEEP). Epidemiological data and cervical cytology, high risk human papillomavirus (HR-HPV) detection and colposcopy with directed biopsy and endocervical curettage if necessary prior to LEEP were reviewed and correlation of missed CIN(2+) and all the above factors analyzed.
  
  
  RESULTS
  Among these patients, 85 cases (31.0%) of CIN(2+) were detected. Univariate analysis showed that poor cervical cytology before colposcopy, unsatisfactory colposcopy and positive HR-HPV detection were risk factors of missed CIN(2+) in low-grade SIL pathologically diagnosed by colposcopy-assisted biopsy. Multivariate logistic analysis showed that whether colposcopic examination was satisfactory or not and cervical cytology before colposcopy were independent risk factors of missed CIN(2+) in low-grade SIL pathologically diagnosed by colposcopy-assisted biopsy (OR: 2.06 and 4.67 respectively).
  
  
  CONCLUSIONS
  The accuracy of colposcopy-assisted biopsy for the diagnosis of CIN(1) remains poor. Whether colposcopic examination is satisfactory or not and cervical cytology before colposcopy are independent risk factors of missed CIN(2+) in low-grade SIL pathologically diagnosed by colposcopy-assisted biopsy.
authors.affiliation: Obstetrics & Gynecology Hospital Affiliated to College of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Yi-fan
authors.initials: YF
authors.lastname: Cheng
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Wang
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Lü
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Cheng
authors.forename: Xing
authors.initials: X
authors.lastname: Xie
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods*; D003127:Colposcopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*