title: Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems.
abstract: DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have revealed a complexity beyond that initially expected, with inter- and intrapathway complementation as well as functional interactions between proteins involved in repair pathways. In this paper we give a broad overview of the whole DNA repair system and focus on the molecular basis of the repair machineries, particularly in Thermus thermophilus HB8.
authors.affiliation: Department of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Rihito
authors.initials: R
authors.lastname: Morita
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakane
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Shimada
authors.forename: Masao
authors.initials: M
authors.lastname: Inoue
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Iino
authors.forename: Taisuke
authors.initials: T
authors.lastname: Wakamatsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Fukui
authors.forename: Noriko
authors.initials: N
authors.lastname: Nakagawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Masui
authors.forename: Seiki
authors.initials: S
authors.lastname: Kuramitsu