title: GPR56 is essential for testis development and male fertility in mice.
abstract: Testis development is critical for male fertility and continuation of the mammalian species. Essential structural components of testes are seminiferous tubules, which are lined by Sertoli cells and provide nutrients and physical protection for the maturation of sperm. Seminiferous tubule formation is initiated in embryos as testis cords and relies on their remodeling for maturation during development. Recently, three-dimensional image analyses showed that testis cords in different parts of embryonic gonads undergo distinct remodeling processes. How this asymmetric remodeling is regulated has not been investigated. We report here that the absence of an adhesion G protein-coupled receptor, GPR56, leads to partial disruption of seminiferous tubules and reduced fertility in male mice. The defects appear to originate asymmetrically in embryonic gonads, but subsequent to the initial establishment of testis cords, suggesting that GPR56 might act to establish a spatial and/or temporal cue for asymmetric cord remodeling during male gonad development.
authors.affiliation: Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA.
authors.forename: Guangchun
authors.initials: G
authors.lastname: Chen
authors.forename: Liquan
authors.initials: L
authors.lastname: Yang
authors.forename: Shahinoor
authors.initials: S
authors.lastname: Begum
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005298:Fertility / Q000235:genetics / Q000502:physiology*; D015151:Immunoblotting; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D012671:Seminiferous Tubules / Q000166:cytology / Q000378:metabolism; D012708:Sertoli Cells / Q000166:cytology / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; C524781:Adgrg1 protein, mouse