title: Stroke after treatment with bortezomib and dexamethasone in a Chinese patient with extramedullary relapse of multiple myeloma.
abstract: Thromboembolic complications commonly occur in patients with multiple myeloma (MM). The risk of such complications may be elevated by the use of immunomodulatory agents such as thalidomide and lenalidomide as initial therapy for MM. However, arterial thrombosis after treatment with bortezomib is rare. Herein we report a case of a 70-year-old Chinese male patient with extramedullary relapse of MM. After treatment with bortezomib and dexamethasone he developed a nonfatal thrombotic stroke. Administration of bortezomib and dexamethasone was then discontinued and he obtained partial remission.
authors.affiliation: Department of Hematology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, P.R. China. guohongf2000@yahoo.com.cn
authors.forename: H F
authors.initials: HF
authors.lastname: Guo
authors.forename: H L
authors.initials: HL
authors.lastname: Su
authors.forename: J J
authors.initials: JJ
authors.lastname: Mao
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D002681:China; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology; D011719:Pyrazines / Q000008:administration & dosage; D012008:Recurrence; D020521:Stroke / Q000139:chemically induced*; D013927:Thrombosis / Q000139:chemically induced*; D016896:Treatment Outcome
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone