title: The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration.
abstract: OBJECTIVE
  Tissue levels of asymmetric dimetilarginine (ADMA) and symmetric dimetilarginine (SDMA) were investigated in cardiac ventricle and gastrocnemius muscles of guinea pigs treated with radioactive iodine (RAI) alone or in combination with L-carnitine (LC).
  
  
  METHODS
  Group 1 received no treatment (control group). Group 2 received a total dose of 30 mCi⁻¹kg⁻¹ body weight iodine-131 alone. Group 3 received 200 mg⁻¹kg⁻¹ of LC for 10 days alone. Group 4 received 200 mg⁻¹kg⁻¹ of LC plus RAI therapy. Free thyroid hormones, ADMA and SDMA concentrations were measured.
  
  
  RESULTS
  Serum free thyroid hormone concentrations were found decreased in the RAI and LC-RAI groups after RAI application. A significant decrease in ADMA and SDMA concentration was observed in ventricle muscle following RAI application. The LC-RAI group had significantly decreased ADMA levels in ventricle muscle compared with those of the control group. Similarly, SDMA concentrations in ventricle and gastrocnemius muscles of the LC-RAI groups were significantly lower than those of the control groups.
  
  
  CONCLUSIONS
  Our results indicated that RAI appears to exert an inhibitory effect on ADMA and SDMA levels of ventricular muscle. LC administration when given adjuvant to RAI therapy may cause a marked decrease in ADMA concentrations of both ventricular and gastrocnemius muscles.
authors.affiliation: Department of Physiology, Trakya University Faculty of Medicine, Edirne, Turkey. arzuvardar@trakya.edu.tr
authors.forename: Selma Arzu
authors.initials: SA
authors.lastname: Vardar
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gunduz
authors.forename: Gulay Durmus
authors.initials: GD
authors.lastname: Altun
authors.forename: Nurettin
authors.initials: N
authors.lastname: Aydogdu
authors.forename: Hakan
authors.initials: H
authors.lastname: Karadag
authors.forename: Nese
authors.initials: N
authors.lastname: Torun
authors.forename: Oktay
authors.initials: O
authors.lastname: Kaya
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D002331:Carnitine / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000528:radiation effects*; D006709:Homoarginine / Q000378:metabolism; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000528:radiation effects*; D009206:Myocardium / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D011837:Radiation-Protective Agents; D013963:Thyroid Hormones; D006709:Homoarginine; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine; D002331:Carnitine