title: Nonmyeloablative allogeneic stem cell transplantation for nasopharyngeal carcinoma.
abstract: We present a case of a patient with metastatic nasopharyngeal carcinoma who failed two lines of palliative combination chemotherapy and was treated with allogeneic nonmyeloablative stem cell transplantation (NST). This patient achieved a durable tumor response, dramatic relief of his symptoms, and elimination of tumor in his bone marrow-an effect likely achieved via a graft-versus-tumor response. Although NST has been explored previously in solid tumors, such as renal cell carcinoma and breast cancer, it has not been widely explored in nasopharyngeal carcinoma. We also present data from a flow cytometric immune analysis and cytokine enzyme-linked immunosorbent assay analysis in the pre- and post-NST period.
authors.affiliation: National Cancer Centre, Department of Medical Oncology, Singapore.
authors.forename: Whay K
authors.initials: WK
authors.lastname: Chia
authors.forename: Who W
authors.initials: WW
authors.lastname: Wang
authors.forename: Wan T
authors.initials: WT
authors.lastname: Lim
authors.forename: Wai M
authors.initials: WM
authors.lastname: Tai
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Choon H
authors.initials: CH
authors.lastname: Thng
authors.forename: Yatanar
authors.initials: Y
authors.lastname: Soe
authors.forename: Swee P
authors.initials: SP
authors.lastname: Yap
authors.forename: Eng H
authors.initials: EH
authors.lastname: Tan
authors.forename: Han C
authors.initials: HC
authors.lastname: Toh
mesh_terms: D019046:Bone Marrow Neoplasms / Q000556:secondary; D002277:Carcinoma; D004359:Drug Therapy, Combination / Q000009:adverse effects; D058501:Enzyme-Linked Immunospot Assay; D005434:Flow Cytometry; D020350:Graft vs Tumor Effect; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000628:therapy; D009362:Neoplasm Metastasis / Q000628:therapy; D010166:Palliative Care; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous