title: [Age features of pure leukoaraiosis in non-demented outpatients].
abstract: OBJECTIVE
  To investigate the aging features of pure leukoaraiosis (LA) in non-demented outpatients.
  
  
  METHODS
  The outpatients with age older than 40 years, without taking cholesterol lowering and B vitamin medications and with mini-mental state examination more than 24 scores were selected from July 2008 to December. 2009 in Beijing Tiantan Hospital. LA was defined with MRI. Patients were classified into two groups i.e. LA group consisting of 138 patients with leukoaraiosis but without lacunar lesions and cortical infarcts and a control group consisting of 124 patients without any lesion in brain. Age and other vascular risk factors were also investigated.
  
  
  RESULTS
  Age of the patients in the LA group was significantly higher than that in the control group (P<0.001). Multivariable logistic regression analysis showed that age was independently associated with pure LA (OR 1.080, 95%CI 1.042-1.120), after adjusting sex, vascular risk factors and presence of atherosclerosis in cervical arteries. If age-stratification was further considered, logistic regression analysis showed that OR (95%CI) for LA was 2.693 (95%CI 1.103-6.575) in a 60-69 year group and 13.527 (95%CI 3.319-55.131) in a ≥70 year group as compared with a 40-49 year group.
  
  
  CONCLUSIONS
  Age is a determining risk factor for pure LA and patients with age older than 60 years are at high risk of LA.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Xue-ying
authors.initials: XY
authors.lastname: Yu
authors.forename: Gui-hong
authors.initials: GH
authors.lastname: Wang
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Guan
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Su-xiang
authors.initials: SX
authors.lastname: Wang
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Yong-jun
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D017677:Age Distribution; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012307:Risk Factors