title: Altered gentamicin serum concentrations in obese pediatric patients.
abstract: We performed a retrospective case-cohort study of 50 obese pediatric patients aged 2 to 18 years who received scheduled gentamicin therapy, with serum peak and trough concentrations measured. Obese pediatric patients had significantly higher gentamicin serum peak and trough concentrations despite receiving significantly lower mg/kg of actual body weight doses of gentamicin.
authors.affiliation: Department of Pharmacy, Texas Children's Hospital, Houston, TX, USA. jachoi@texaschildrens.org.
authors.forename: Jamie J
authors.initials: JJ
authors.lastname: Choi
authors.forename: Brady S
authors.initials: BS
authors.lastname: Moffett
authors.forename: Erin J
authors.initials: EJ
authors.lastname: McDade
authors.forename: Debra L
authors.initials: DL
authors.lastname: Palazzi
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D012189:Retrospective Studies; D044967:Serum / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins