Population structure of Aggarwals of north India as revealed by molecular markers.
Using molecular genetic data on Aggarwals (Vaish/Vysya), an endogamous population group of north India, we provide evidence of its homogeneous unstratified population structure. We found the mean average heterozygosity value of 0.33 for 14 single nucleotide polymorphisms belonging to four genes (TCF7L2-, HHEX-, KCNJ11-, and ADIPOQ-) in the Aggarwal population (sample of 184 individuals) and tried to evaluate the genomic efficiency of endogamy in this population with the help of clan-based stratified analysis. We concluded that the sociocultural identity of the endogamous population groups could act as a robust proxy maker for inferring their homogeneity and population structure in India, which is ideal also for population selection for future genome-wide association studies in the country.
Gupta
Vipin
V
South Asia Network for Chronic Disease (SANCD), Public Health Foundation of India, New Delhi, India.
Khadgawat
Rajesh
R
Ng
Hon Keung Tony
HK
Kumar
Satish
S
Rao
Vadlamudi Raghavendra
VR
Sachdeva
Mohinder Pal
MP
D052242:Adiponectin / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008393:Marriage; D011110:Polymorphism, Genetic; D011153:Population / Q000235:genetics*; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D000099161:Kcnj11 Channel
D052242:Adiponectin; D005819:Genetic Markers; D018398:Homeodomain Proteins; D024661:Potassium Channels, Inwardly Rectifying; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; D000099161:Kcnj11 Channel; C078492:HHEX protein, human; C544894:TCF7L2 protein, human