title: Gadolinium Enhanced MR Coronary Vessel Wall Imaging at 3.0 Tesla.
abstract: Purpose. We evaluated the influence of the time between low-dose gadolinium (Gd) contrast administration and coronary vessel wall enhancement (LGE) detected by 3T magnetic resonance imaging (MRI) in healthy subjects and patients with coronary artery disease (CAD). Materials and Methods. Four healthy subjects (4 men, mean age 29 ± 3 years and eleven CAD patients (6 women, mean age 61 ± 10 years) were studied on a commercial 3.0 Tesla (T) whole-body MR imaging system (Achieva 3.0 T; Philips, Best, The Netherlands). T1-weighted inversion-recovery coronary magnetic resonance imaging (MRI) was repeated up to 75 minutes after administration of low-dose Gadolinium (Gd) (0.1 mmol/kg Gd-DTPA). Results. LGE was seen in none of the healthy subjects, however in all of the CAD patients. In CAD patients, fifty-six of 62 (90.3%) segments showed LGE of the coronary artery vessel wall at time-interval 1 after contrast. At time-interval 2, 34 of 42 (81.0%) and at time-interval 3, 29 of 39 evaluable segments (74.4%) were enhanced. Conclusion. In this work, we demonstrate LGE of the coronary artery vessel wall using 3.0 T MRI after a single, low-dose Gd contrast injection in CAD patients but not in healthy subjects. In the majority of the evaluated coronary segments in CAD patients, LGE of the coronary vessel wall was already detectable 30-45 minutes after administration of the contrast agent.
authors.affiliation: Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kelle
authors.forename: Kelly
authors.initials: K
authors.lastname: Schlendorf
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Hirsch
authors.forename: Gary
authors.initials: G
authors.lastname: Gerstenblith
authors.forename: Eckart
authors.initials: E
authors.lastname: Fleck
authors.forename: Robert G
authors.initials: RG
authors.lastname: Weiss
authors.forename: Matthias
authors.initials: M
authors.lastname: Stuber