Optimizing soy isoflavones effect in postmenopausal women: the impact of timing on climacteric symptoms.
BACKGROUND
The most common complaints during climacteric are vasomotor symptoms. A circadian rhythm has been observed when hot flashes start; however, not much information is available in this field.


OBJECTIVE
To analyze whether the time (morning/evening) of administration of a compound containing 60 mg of dry soy seed extract (glycine max) with 40% of total isoflavones, primrose oil and α-tocopherol modifies the effect on the climacteric syndrome.


METHODS
Multicentric, observational, open, prospective, longitudinal and cross-sectional study. Subjects and methods. One thousand six hundred eighty-two postmenopausal women with climacteric symptoms were allocated in two groups in order to receive the treatment in the morning (Group 1) or in the evening (Group 2), switching administration time after 3 months. Clinical evaluation was carried out at 0, 3 and 6 months of follow-up using Blatt-Kupperman and Greene scales.


RESULTS
233 (13.9%) women dropped out from the study. Both administration times improved the climacteric symptoms after 3 and 6 months of treatment, showing a reduction in the scores of Blatt-Kupperman and Greene scales (p < 0.001). No differences between both groups during the follow-up were identified.


CONCLUSIONS
The time of administration of isoflavones does not modify its effect on climacteric symptoms.
Cancelo Hidalgo
Maria Jesús
MJ
Hospital Universitario de Guadalajara, Universidad de Alcalá de Henares, Spain.
Castelo Branco
Camil
C
D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage*; D008137:Longitudinal Studies; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D017698:Postmenopause; D011446:Prospective Studies; D013025:Glycine max
D007529:Isoflavones; D010936:Plant Extracts