title: [Correlation of microsatellite alterations on chromosome 9 and oncogenesis,metastasis in NSCLC].
abstract: BACKGROUND
  To investigate the relationship among microsatellite alterations on chromosome 9(9p) and the oncogenesis,metastasis of non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Two microsatellite markers,IFNA and D9S171,were analyzed in 32 cases of NSCLC by polymerase chain reaction-based silver-staining assay.
  
  
  RESULTS
  Of 32 cases of NSCLC,14(43.8%) had microsatellite alterations.The alteration frequency was 64.7% in NSCLC with lymph node metastasis,and 20% in those without lymph node metastasis.There was significant difference between the two groups.None of benign lung tissues showed microsatellite alterations.
  
  
  CONCLUSIONS
  Microsatellite alteration on chromosome 9p in NSCLC appears to be a common and specific event,and may be a valuable molecular marker for determination of early diagnosis and metastasis of NSCLC.
authors.affiliation: Laboratory of Molecular Biology,Henan Provincial Chest Hospital,Zhengzhou,Henan 450003,P.R.China.
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Tang
authors.forename: Q
authors.initials: Q
authors.lastname: Liang
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.forename: L
authors.initials: L
authors.lastname: Yang