Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis.
Lymphangioleiomyomatosis is a rare cause of pneumothorax in women. We present the case of a 48-year-old woman with lymphangioleiomyomatosis, who had never had a pneumothorax prior to commencing chemotherapy for breast cancer. During chemotherapy she developed 3 pneumothoraces and 2 episodes of pneumomediastinum. We suggest that the pneumothoraces were caused by the chemotherapy. To our knowledge, this is the first reported case of chemotherapy triggering pneumothoraces in a woman with lymphangioleiomyomatosis.
Kelly
Emer
E
Department of Medicine and Therapeutics, University College Dublin, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. emermariekelly@hotmail.com
Mhurchu
Elaine Ni
EN
Sukor
Sumainizah
S
McDonnell
Timothy J
TJ
Tryfonopoulos
Dimitrios
D
Keane
Michael P
MP
D000911:Antibodies, Monoclonal / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077341:Lapatinib; D008175:Lung Neoplasms / Q000150:complications* / Q000628:therapy; D018192:Lymphangioleiomyomatosis / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D010102:Oxygen Inhalation Therapy; D011030:Pneumothorax / Q000139:chemically induced* / Q000150:complications*; D011799:Quinazolines / Q000009:adverse effects; D000068878:Trastuzumab
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D011799:Quinazolines; D000077341:Lapatinib; D000068878:Trastuzumab