title: Population structure of Aggarwals of north India as revealed by molecular markers.
abstract: Using molecular genetic data on Aggarwals (Vaish/Vysya), an endogamous population group of north India, we provide evidence of its homogeneous unstratified population structure. We found the mean average heterozygosity value of 0.33 for 14 single nucleotide polymorphisms belonging to four genes (TCF7L2-, HHEX-, KCNJ11-, and ADIPOQ-) in the Aggarwal population (sample of 184 individuals) and tried to evaluate the genomic efficiency of endogamy in this population with the help of clan-based stratified analysis. We concluded that the sociocultural identity of the endogamous population groups could act as a robust proxy maker for inferring their homogeneity and population structure in India, which is ideal also for population selection for future genome-wide association studies in the country.
authors.affiliation: South Asia Network for Chronic Disease (SANCD), Public Health Foundation of India, New Delhi, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Gupta
authors.forename: Rajesh
authors.initials: R
authors.lastname: Khadgawat
authors.forename: Hon Keung Tony
authors.initials: HK
authors.lastname: Ng
authors.forename: Satish
authors.initials: S
authors.lastname: Kumar
authors.forename: Vadlamudi Raghavendra
authors.initials: VR
authors.lastname: Rao
authors.forename: Mohinder Pal
authors.initials: MP
authors.lastname: Sachdeva
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008393:Marriage; D011110:Polymorphism, Genetic; D011153:Population / Q000235:genetics*; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D000099161:Kcnj11 Channel
chemical_list: D052242:Adiponectin; D005819:Genetic Markers; D018398:Homeodomain Proteins; D024661:Potassium Channels, Inwardly Rectifying; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; D000099161:Kcnj11 Channel; C078492:HHEX protein, human; C544894:TCF7L2 protein, human