title: Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γ/IL-4 Ratio In Utero in Pregnant Mice.
abstract: The objective of this study is to investigate the antiabortive effects of Quercetin and Bornvl Acetate and their immunological modulation at maternal-fetal interface. Lipopolysaccharide (LPS) was injected via tail vein to induce abortion in mice which received Quercetin and Bornvl Acetate at days 4-7 of gestation. Uterine CD4+/CD8+ T lymphocytes and IFN-γ/IL-4 of each group (n = 10) were detected by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. The ratio of CD4+/CD8+ increased significantly (P < .01) in the uterus of LPS-induced abortion mice. In the Quercetin and Bornvl Acetate pretreated mice followed by LPS administration, the ratio of CD4+/CD8+ dropped to 0.562 ± 0.021, lower than that of LPS-abortion group (P < .01). The mean value of IFN-γ/IL-4 in LPS-treated mice was 0.310 ± 0.066, higher than that of Quercetin and Bornyl Acetate group. The results indicate that Quercetin and Bornyl Acetate have an antiabortive effect through modulation of immunological balance at maternal-fetal interface.
authors.affiliation: College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wang
authors.forename: Aituan
authors.initials: A
authors.lastname: Ma
authors.forename: Wanyu
authors.initials: W
authors.lastname: Shi
authors.forename: Meiying
authors.initials: M
authors.lastname: Geng
authors.forename: Xiuhui
authors.initials: X
authors.lastname: Zhong
authors.forename: Yantao
authors.initials: Y
authors.lastname: Zhao