title: MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients.
abstract: A single-nucleotide polymorphism in the MDM2 promoter (SNP309; rs2279744) causes elevated transcription of this major negative regulator of p53 in several cancer types. We investigated MDM2 SNP309 and CDKN1A (p21/Waf1/Cip1) codon 31 (rs1801270) polymorphisms in 86 cases of cutaneous Kaposi's sarcoma (KS) from African and Caucasian patients, and 210 healthy controls. A significant increase of the MDM2 SNP309 T/G genotype was observed among classic KS cases (odds ratio 2.38, 95% confidence interval 1.0-5.5). Frequencies of CDKN1A codon 31 genotypes were not significantly different between cases and controls. The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients.
authors.affiliation: Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, 'Fondazione Pascale', Naples, Italy.
authors.forename: Maria Lina
authors.initials: ML
authors.lastname: Tornesello
authors.forename: Luigi
authors.initials: L
authors.lastname: Buonaguro
authors.forename: Medea
authors.initials: M
authors.lastname: Cristillo
authors.forename: Bennon
authors.initials: B
authors.lastname: Biryahwaho
authors.forename: Robert
authors.initials: R
authors.lastname: Downing
authors.forename: Angelo
authors.initials: A
authors.lastname: Hatzakis
authors.forename: Elvio
authors.initials: E
authors.lastname: Alessi
authors.forename: Marco
authors.initials: M
authors.lastname: Cusini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ruocco
authors.forename: Enza
authors.initials: E
authors.lastname: Viviano
authors.forename: Nino
authors.initials: N
authors.lastname: Romano
authors.forename: Edward
authors.initials: E
authors.lastname: Katongole-Mbidde
authors.forename: Franco M
authors.initials: FM
authors.lastname: Buonaguro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2