[Significances of NT-proBNP and hs-CRP in heart failure].
OBJECTIVE
To detect the level changes of plasma N-terminal B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) in patients with heart failure (HF) and explore their clinical correlations and prognostic significances.


METHODS
A total of 100 cases of HF patients were selected along with 20 age and gender-matched controls. The levels of NT-proBNP and hs-CRP were tested.


RESULTS
The levels of NT-proBNP were significantly higher in HF patients than the controls. And the difference was statistically significant (P < 0.01). In congestive HF patients, the elevating magnitude of plasma NT-proBNP level showed a significantly positive correlation with that of hs-CRP during the same period.


CONCLUSIONS
(1) The level of NT-proBNP is significantly higher in HF patients. And it can be used as one of auxiliary diagnostic indicators. (2) The level of NT-proBNP in conjunction with hs-CRP can predict the prognosis of HF patients.
Wang
Li
L
Department of Emergency Medicine, Jiading Branch of Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai 201800, China. wangli@189.cn
Hu
Shan-You
SY
Wu
Xiao
X
Jü
Xue-Feng
XF
D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein