title: [Stroke volume variation in the evaluation of fluid responsiveness in refractory septic shock].
abstract: OBJECTIVE
  To evaluate fluid responsiveness by stroke volume variation(SVV) in mechanically ventilated patients with refractory septic shock.
  
  
  METHODS
  Forty-two refractory septic shock patients were enrolled in the study. According to the responsiveness of fluid loading, the patients were divided into responsive group and non-responsive group. The SVV values of two groups were retrospectively analyzed. The receiver operating characteristic curve was drafted to determine the cut-off value of SVV for predicting fluid responsiveness.
  
  
  RESULTS
  Among the 42 refractory septic shock patients, 24 were found responsive to fluid loading, 18 were not; before the fluid loading, central venous pressure, heart rate, mean arterial pressure and global end-diastolic volume index in the both groups showed no significant differences whereas the SVV in the responsive group was much higher than that in the nonresponsive group (P=0.006). Using SVV≥12% as the threshold to predict fluid responsiveness, the sensitivity was 77%, specificity was 85%.
  
  
  CONCLUSIONS
  SVV can accurately predict fluid responsiveness in refractory septic shock patients.
authors.affiliation: Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Hong-min
authors.initials: HM
authors.lastname: Zhang
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Liu
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Rui
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Huai-wu
authors.initials: HW
authors.lastname: He
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiu-kai
authors.initials: XK
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D002496:Central Venous Pressure; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012772:Shock, Septic / Q000503:physiopathology*; D013318:Stroke Volume