Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges.
Marine sponges belonging to the Calcarea family have been studied for some time and have yielded a wide variety of structurally unique secondary metabolites. In particular, these sponges have produced a large number of bioactive alkaloids containing an imidazole heterocycle, typically substituted with two benzylic fragments at various locations around the azole nucleus and at various oxidation states. This review will describe the isolation, structural determination and synthetic studies towards this growing class of natural products.
Koswatta
Panduka B
PB
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, USA. lovely@uta.edu
Lovely
Carl J
CJ
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D001688:Biological Products; D007093:Imidazoles; C014973:2-aminoimidazole