Nonmyeloablative allogeneic stem cell transplantation for nasopharyngeal carcinoma.
We present a case of a patient with metastatic nasopharyngeal carcinoma who failed two lines of palliative combination chemotherapy and was treated with allogeneic nonmyeloablative stem cell transplantation (NST). This patient achieved a durable tumor response, dramatic relief of his symptoms, and elimination of tumor in his bone marrow-an effect likely achieved via a graft-versus-tumor response. Although NST has been explored previously in solid tumors, such as renal cell carcinoma and breast cancer, it has not been widely explored in nasopharyngeal carcinoma. We also present data from a flow cytometric immune analysis and cytokine enzyme-linked immunosorbent assay analysis in the pre- and post-NST period.
Chia
Whay K
WK
National Cancer Centre, Department of Medical Oncology, Singapore.
Wang
Who W
WW
Lim
Wan T
WT
Tai
Wai M
WM
Sun
Li
L
Thng
Choon H
CH
Soe
Yatanar
Y
Yap
Swee P
SP
Tan
Eng H
EH
Toh
Han C
HC
D019046:Bone Marrow Neoplasms / Q000556:secondary; D002277:Carcinoma; D004359:Drug Therapy, Combination / Q000009:adverse effects; D058501:Enzyme-Linked Immunospot Assay; D005434:Flow Cytometry; D020350:Graft vs Tumor Effect; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000628:therapy; D009362:Neoplasm Metastasis / Q000628:therapy; D010166:Palliative Care; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous