[Expression and significance of CD80/CD86 in renal tissue of lupus nephritis].
OBJECTIVE
To measure the expression of CD80 and CD86 in renal tissue of lupus nephritis (LN) and explore its mechanism in the development of LN.


METHODS
Forty-nine patients with active LN and 9 patients with minor glomerular abnormalities tissues as controls were studied. The expression of CD80 and CD86 in renal tissues was detected by immunohistochemical methods.


RESULTS
CD86 was expressed extensively in glomerulus, periglomerular area, tubular epithelial cells and peritubular interstitium, while CD80 was expressed only in tubular epithelial cells and peritubular interstitium. Moreover, the percentage of CD80+ and CD86+ cells in tubular epithelial cells and peritubular interstitium showed a tendency to increase with tubulointerstitial damage. The expression of CD80 and CD86 in renal tissue correlated with the systemic lupus erythematosus (SLE) disease activity index score, the degree of proteinuria, creatinine clearance and anti-dsDNA antibody.


CONCLUSIONS
This study shows that increased CD80 and CD86 expression with the progression of tubulointerstitial lesion might play an important role in the development of lupus nephropathy, and the tubulointerstitial expression of CD80 and CD86 could potentially serve as a surrogate marker of SLE disease activity. The co-stimulatory molecules CD80 and CD86 might play an important role in the pathogenesis of LN.
Sui
Man-shu
MS
Department of Nephrology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, China. docter_sms@yeah.net
Zhou
Jin
J
Jia
Xi-bei
XB
Mu
Su-hong
SH
Liu
Xiao-gang
XG
Ji
Ying
Y
Xie
Ru-juan
RJ
D000293:Adolescent; D000328:Adult; D018122:B7-1 Antigen / Q000378:metabolism*; D051940:B7-2 Antigen / Q000378:metabolism*; D001706:Biopsy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008181:Lupus Nephritis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D018122:B7-1 Antigen; D051940:B7-2 Antigen