title: [The clinical features of ectopic ACTH syndrome: a report of 16 cases].
abstract: OBJECTIVE
  To improve the diagnostic and therapeutic ability of ectopic ACTH syndrome by analysing its clinical features.
  
  
  METHODS
  Sixteen cases of ectopic ACTH syndrome diagnosed in Chinese PLA General Hospital from 2000 to 2009 were analyzed retrospectively.
  
  
  RESULTS
  (1) The main causes of ectopic ACTH syndrome were lung tumor and thymic carcinoid; (2) Abnormal glucose metabolism, hypertension, hypokalemia and edema of both lower limbs were the most common clinical symptoms; (3) Laboratory examination showed a significant increase of serum cortisol, adrenocorticotropic hormone (ACTH) and 24 h urinary free cortisol (24hUFC) together with severe hypokalemia and alkalosis; (4) High dose dexamethasone suppressing test, corticotrophin-releasing hormone (CRH) stimulating test and petrosal sinus sampling were the most meaningful diagnostic methods; (5) Most of the primary lesions might be detected with chest film and CT; (6) Resection of the primary lesion was the treatment of first choice.
  
  
  CONCLUSIONS
  The diagnosis of ectopic ACTH syndrome is very hard. Resection of the primary lesion is the best treatment.
authors.affiliation: Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Chun-lin
authors.initials: CL
authors.lastname: Li
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Mu
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
authors.forename: Ju-ming
authors.initials: JM
authors.lastname: Lu
authors.forename: Chang-yu
authors.initials: CY
authors.lastname: Pan
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies