Comparative evaluation of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 version 2 test using the TaqMan 48 analyzer and the Abbott RealTime HIV-1 assay.
Acceptable precision was achieved in a comparison study of the Abbott RealTime (RT) and Roche CAP/CTM-48 V2 HIV-1 assays, but viral load quantification was under- and overestimated, respectively, compared to the 2nd HIV-1 WHO International Standard. The same quantification patterns were observed for patient cohorts from Africa and the United States.
van Rensburg
Estrelita Janse
EJ
Quintiles Global Central Laboratories, The Alba Campus, Rosebank, Livingston EH54 7EG, United Kingdom. Estrelita.JanseVanRensburg@quintiles.com
Tait
Karen
K
Watt
Alistair
A
Schall
Robert
R
D000349:Africa; D015658:HIV Infections / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D011933:Reagent Kits, Diagnostic; D014481:United States; D019562:Viral Load / Q000379:methods*
D011933:Reagent Kits, Diagnostic