title: Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis.
abstract: Lymphangioleiomyomatosis is a rare cause of pneumothorax in women. We present the case of a 48-year-old woman with lymphangioleiomyomatosis, who had never had a pneumothorax prior to commencing chemotherapy for breast cancer. During chemotherapy she developed 3 pneumothoraces and 2 episodes of pneumomediastinum. We suggest that the pneumothoraces were caused by the chemotherapy. To our knowledge, this is the first reported case of chemotherapy triggering pneumothoraces in a woman with lymphangioleiomyomatosis.
authors.affiliation: Department of Medicine and Therapeutics, University College Dublin, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. emermariekelly@hotmail.com
authors.forename: Emer
authors.initials: E
authors.lastname: Kelly
authors.forename: Elaine Ni
authors.initials: EN
authors.lastname: Mhurchu
authors.forename: Sumainizah
authors.initials: S
authors.lastname: Sukor
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: McDonnell
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tryfonopoulos
authors.forename: Michael P
authors.initials: MP
authors.lastname: Keane
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077341:Lapatinib; D008175:Lung Neoplasms / Q000150:complications* / Q000628:therapy; D018192:Lymphangioleiomyomatosis / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D010102:Oxygen Inhalation Therapy; D011030:Pneumothorax / Q000139:chemically induced* / Q000150:complications*; D011799:Quinazolines / Q000009:adverse effects; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D011799:Quinazolines; D000077341:Lapatinib; D000068878:Trastuzumab