[The risk predictive value of high sensitivity C-reactive protein level for new hemorrhagic stroke events].
OBJECTIVE
To study the risk prediction for new intracerebral hemorrhage (ICH) with high sensitivity C-reactive protein (hs-CRP) level.


METHODS
In a retrospective, nested, case-controlled study, 323 cases of ICH were identified and matched with 646 controls. The hs-CRP levels at baseline were compared between the two groups. The relevance of different hs-CRP levels and the risk of ICH were analyzed.


RESULTS
The ICH group had a higher median hs-CRP levels (1.10 mg/L) as compared with the control group (0.66 mg/L) with significant difference (P<0.01). In addition, the increase of risk associated with hs-CRP levels was primarily observed in the individuals with the highest quartile of hs-CRP levels (>2.12 mg/L). These patients had an increased risk of ICH (OR 2.58, 95%CI 1.77 to 3.76) as compared with those in the lowest quartile (≤0.30 mg/L). Individuals with baseline hs-CRP levels above the specified cut point of 3 mg/L or more and those in the 80th percentile were at a markedly increased risk of ICH (for specified cut point of 3 mg/L, OR 2.26, 95%CI 1.60 - 3.20, P<0.01; for 80th percentile, OR 2.24, 95%CI 1.60 - 3.13, P<0.01, respectively).


CONCLUSIONS
Risk of ICH might be predicted with the level of hs-CRP. With the increase of hs-CRP level at baseline, the risk of ICH was increased.
Zhu
Jie
J
Department of Cardiology, the Affiliated Kailuan Hospital, North China Coal Medical College, Tangshan 063000, China.
Wu
Shou-ling
SL
Wang
Yan-xiu
YX
Wang
Jian-li
JL
Zhao
Hong-tao
HT
Hou
Guo-sheng
GS
Li
Dong-qing
DQ
Jin
Cheng
C
Li
Jin-feng
JF
Di
Yan-rong
YR
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis*
D002097:C-Reactive Protein