title: Antiplasmodial activity of three bisbenzylisoquinoline alkaloids from the tuber of Stephania rotunda.
abstract: Three bisbenzylisoquinoline alkaloids were isolated for the first time from Stephania rotunda tuber. Their structures were elucidated by spectroscopic methods and their antiplasmodial activity was investigated in vitro on chloroquine resistant Plasmodium falciparum strain W2. These alkaloids were identified as 2-norcepharanthine (1), cepharanoline (2) and fangchinoline (3). In vitro, they displayed significant antiplasmodial activity with inhibitory concentration 50 values of 0.3, 0.2 and 0.3 µM.
authors.affiliation: Laboratory of Ethnopharmacology and Pharmacognosy, UMR-MD3, Faculty of Pharmacy, University of the Mediterranean Aix-Marseille II, Marseille, France.
authors.forename: Aun
authors.initials: A
authors.lastname: Chea
authors.forename: Sok-Siya
authors.initials: SS
authors.lastname: Bun
authors.forename: Nadine
authors.initials: N
authors.lastname: Azas
authors.forename: Monique
authors.initials: M
authors.lastname: Gasquet
authors.forename: Sothavireak
authors.initials: S
authors.lastname: Bory
authors.forename: Evelyne
authors.initials: E
authors.lastname: Ollivier
authors.forename: Riad
authors.initials: R
authors.lastname: Elias
mesh_terms: D000962:Antimalarials / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044182:Benzylisoquinolines / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002160:Cambodia; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035281:Plant Tubers / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D031607:Stephania / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D044182:Benzylisoquinolines; C060802:fangchinoline