title: The effect of comprehensive infection control measures on the rate of late-onset bloodstream infections in very low-birth-weight infants.
abstract: Late-onset bloodstream infection (LOBI) is a significant problem in very low-birth-weight (VLBW) infants and can lead to increased mortality and morbidity. The incidence of LOBI in VLBW infants in our unit was >35% before 2004, much higher than 20% reported in other studies. A comprehensive infection control measure was introduced in our unit in 2005. Here we report the effects of comprehensive infection control measures on the rate of LOBI in VLBW infants. Infants in the preintervention group (born 2001 to 2004) were compared with the intervention group (born 2005 to 2008) for baseline demographics, risk factors for infection, and the rate of LOBI. LOBI was defined as a positive blood and/or cerebrospinal fluid culture after 3 days of life. Three hundred thirty-four VLBW infants were admitted to our unit during the preintervention period and 303 during the intervention period. There was no significant difference in baseline demographics and risk factors for LOBI between the two groups. The incidence of LOBI was significantly reduced from 38% before intervention to 23% after intervention ( P < 0.001). Comprehensive infection control measures significantly reduced the rate of LOBI in VLBW infants.
authors.affiliation: Department of Pediatrics/Neonatology, Cooper University Hospital, Camden, NJ 08103, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Wicker
authors.forename: Judy
authors.initials: J
authors.lastname: Saslow
authors.forename: Sahil
authors.initials: S
authors.lastname: Shah
authors.forename: Vishwanath
authors.initials: V
authors.lastname: Bhat
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Sannoh
authors.forename: Emma
authors.initials: E
authors.lastname: Brandon
authors.forename: Nicole
authors.initials: N
authors.lastname: Kemble
authors.forename: Kee
authors.initials: K
authors.lastname: Pyon
authors.forename: Gary
authors.initials: G
authors.lastname: Stahl
authors.forename: Zubair H
authors.initials: ZH
authors.lastname: Aghai
mesh_terms: D001424:Bacterial Infections / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D017053:Infection Control / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors