title: [An analysis of opportunistic infection in 762 inpatients with human immunodeficiency virus infection in Guangdong areas].
abstract: OBJECTIVE
  To analyze the characteristics of opportunistic infection (OI) in patients with HIV/AIDS in Guangdong and the relationship between OI and the change in blood CD4+ T lymphocyte count (CD4+).
  
  
  METHODS
  Seven hundred and sixty two patients with HIV/AIDS admitted were analyzed.
  
  
  RESULTS
  Among all the 762 patients, 704 (92.39%) had more than one kind of OI, with 1428 episodes totally. Etiologically, fungus infection (38.38%) was most common, followed by bacteria (36.20%), and virus (7.77%) infection. Most OI occurred in the lungs (33.05%), mouth (26.89%), skin (10.29%) and gastro-intestine (8.96%). Septicemia and other systemic disseminated diseases accounted for 6.58% and 9.94% respectively. The incidence of OI in patients with CD4+≥200/µl (103/136, 75.74%) was significantly lower than that in patients with CD4+<200/µl (601/626, 96.01%), P<0.01. All the AIDS defining OI were found in patients with CD4+<200/µl. Among them, 81.97% of patients with pneumonia carinii pneumonia (PCP), 71.43% of patients with cytomegalovirus retinitis and all the patients with cryptococcal meningitis, disseminated cryptococcosis, disseminated histoplasmosis, mycobacterium avium intracellular complex (MAC), disseminated penicilliosis marneffei and toxoplasma cerebritis had the CD4+ less than 50/µl.
  
  
  CONCLUSIONS
  The most common OI in patients with AIDS in Guangdong area are fungi, bacterial and viral infections. Lung, mouth, skin, gastro-intestine and systemic disseminated infections are the most prevalent infections. As the CD4+ decreased, the incidence of OI especially AIDS defining OI increased. Dynamic detection of CD4+ will be of great help for the prediction, prevention, early diagnosis and treatment of OI in patients with AIDS.
authors.affiliation: Guangzhou No.8 People's Hospital, Guangzhou 510060, China.
authors.forename: Li-fen
authors.initials: LF
authors.lastname: Huang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Tang
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Cai
authors.forename: Xie-jie
authors.initials: XJ
authors.lastname: Chen
authors.forename: Chun-liang
authors.initials: CL
authors.lastname: Lei
authors.forename: Ling-hua
authors.initials: LH
authors.lastname: Li
authors.forename: Fu-chun
authors.initials: FC
authors.lastname: Zhang
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology*; D000328:Adult; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors