title: Association between documented coronary artery disease and urinary albumin, albumin to creatinine ratio.
abstract: BACKGROUND
  The aim of this study was to investigate whether the amount of urinary albumin concentration (UAC) or urinary albumin to creatinine ratio (UACR) is more strongly associated with angiographically documented coronary artery disease (CAD).
  
  
  METHODS
  A total of 199 consecutive patients [11 9(60%) male, 80 (40%) female, mean age =57±10] undergoing diagnostic coronary angiography were included in the study. Significant coronary artery disease was defined as a stenosis equal to or above 50% in the main coronary artery or in one of the other branches. UAC and UACR were calculated from the urine. Baseline clinical parameters, UAC and UACR were compared between subjects with and without CAD. Factors predicting CAD were evaluated by multivariate analysis.
  
  
  RESULTS
  Baseline clinical and laboratory characteristics of patients with and without CAD were not different except for a slightly male predominance in patients with CAD. Patients with CAD had significantly higher UACs and UACRs than patients without CAD (32.14±31.27 mg/day vs. 15.61±16.70 mg/day, p=0.01; 9.11±7.42 mg/g vs. 4.80±3.28 mg/g, p=0.009). A positive correlation was found between Gensini score and UACR (p=0.01), whereas no correlation was found between Gensini and UAC. UACR was the only significant parameter for the presence of CAD in the multivariate analysis adjusted for age, sex, other well known CAD risk factors, UAC and UACR.
  
  
  CONCLUSIONS
  Our preliminary results suggest that UACR is more closely associated with angiography documented CAD than is the level of UAC itself, but UACR maybe more significantly associated with angiography documented CAD than with the levels of UAC.
authors.affiliation: Department of Cardiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey. ihubildir@gmail.com
authors.forename: Ulas
authors.initials: U
authors.lastname: Bildirici
authors.forename: Ertan
authors.initials: E
authors.lastname: Ural
authors.forename: Teoman
authors.initials: T
authors.lastname: Kilic
authors.forename: Fatih
authors.initials: F
authors.lastname: Aygun
authors.forename: Eser
authors.initials: E
authors.lastname: Acar
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cekmen
authors.forename: Dilek
authors.initials: D
authors.lastname: Ural
mesh_terms: D000368:Aged; D000418:Albumins / Q000378:metabolism*; D000419:Albuminuria / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000652:urine*; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000418:Albumins; D003404:Creatinine