title: DNA damage response.
abstract: Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.
authors.affiliation: Department of Genetics, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Giglia-Mari
authors.forename: Angelika
authors.initials: A
authors.lastname: Zotter
authors.forename: Wim
authors.initials: W
authors.lastname: Vermeulen
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology*; D042822:Genomic Instability / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D002843:Chromatin; C468783:H2AX protein, human; D006657:Histones