[Application of ROC curve for the evaluation of arterial stiffness and heart function in hypertensive patients by quantitative artery stiffness].
OBJECTIVE
To apply the receiver operating characteristic (ROC) curves and QAS technology in exploring sensitive and feasible indices about the structure and function of heart and arterial stiffness so as to determine the optimal operating point (OOP) and evaluate its value of cardiovascular changes in hypertensive patients.


METHODS
The parameters of arterial stiffness and heart function were measured and calculated in hypertensive patients (n = 167) and control (n = 165). The results were compared and critical values obtained by receiver operating characteristic (ROC) curves.


RESULTS
Interventricular septal thickness, posterior wall thickness of left ventricle, E/e and Tei of hypertensive group were significantly higher than those of control group (P < 0.05). In hypertensive group, the parameters of arterial stiffness including beta, and PWVbeta were significantly higher than those of control group (P < 0.05). The areas of under the ROC curves were 0.808, 0.843, 0.816, 0.827, 0.779 and 0.632. The sensitivity and specificity of detecting the cardiovascular changes of hypertension for interventricular septal thickness, posterior wall thickness of left ventricle, E/e, Tei, PWVbeta and beta were 78.6%/78.9%, 82.1%/84.2%, 67.9%/89.5%, 100%/52.6%, 82.1%/68.4% and 57.1%/63.2% respectively.


CONCLUSIONS
The arterial stiffness and heart dysfunction may result from hypertension. Arterial stiffness can be one of monitoring indices in early-stage damage of heart function.
Ren
Jun-Hong
JH
Department of Ultrasonography, Beijing Hospital, Ministry of Health, Beijing 100730, China.
Han
Xiu-Jie
XJ
Chen
Xiu-Hua
XH
Zhang
Zheng
Z
Li
Jing
J
D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D002320:Cardiovascular Physiological Phenomena; D016022:Case-Control Studies; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D014655:Vascular Resistance