title: Importance of blood pressure control in left ventricular mass regression.
abstract: Blood pressure (BP) reduction to 140/90 mm Hg or lower using renin-angiotensin-system blockers reportedly provides the greatest left ventricular (LV) mass regression; β-blockers have less effect. This study examined whether combination antihypertensive therapy would provide greater benefit. With a double-blind, parallel-group design, the effects of 3 different combinations, carvedilol controlled-release (CR)/lisinopril, atenolol/lisinopril, and lisinopril, on left ventricular mass index (LVMI) were assessed by MRI after 12 months. Patients were treated to achieve guideline-recommended BP (<140 mm Hg/<90 mm Hg; diabetes: <130 mm Hg/<80 mm Hg). Sample size was calculated to achieve 90% power to detect a 5 g/m(2) difference in mean change from baseline in LVMI between the carvedilol CR/lisinopril group and each of the other treatment groups. Of 287 patients randomized, more than 50% were titrated to maximum dosage; 73% reached targeted BP. At month 12 (last observation carried forward ≥ month 9) for 195 evaluable subjects, mean BP was similar in all groups (carvedilol CR/lisinopril: 128.8/77.9; atenolol/lisinopril: 128.7/76.5; lisinopril: 126.3/80.3 mm Hg). Compared with baseline, mean LVMI decreased to a similar extent in all groups (carvedilol CR/lisinopril: -6.3; atenolol/lisinopril: -6.7; lisinopril: -7.9 g/m(2)). Achievement of targeted BP control is more important than treatment regimen in achieving LV mass reduction.
authors.affiliation: Division of Cardiology, Department of Medicine, University of Florida, Jacksonville, Florida 32209, USA. alan.miller@jax.ufl.edu
authors.forename: Alan B
authors.initials: AB
authors.lastname: Miller
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Reichek
authors.forename: Martin
authors.initials: M
authors.lastname: St John Sutton
authors.forename: Malini
authors.initials: M
authors.lastname: Iyengar
authors.forename: Linda S
authors.initials: LS
authors.lastname: Henderson
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Tarka
authors.forename: George L
authors.initials: GL
authors.lastname: Bakris
mesh_terms: D000368:Aged; D000419:Albuminuria; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D002227:Carbazoles / Q000627:therapeutic use; D000077261:Carvedilol; D003404:Creatinine / Q000652:urine; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy* / Q000473:pathology*; D017706:Lisinopril / Q000627:therapeutic use; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use; D014481:United States
chemical_list: D000959:Antihypertensive Agents; D002227:Carbazoles; D003692:Delayed-Action Preparations; D011412:Propanolamines; D000077261:Carvedilol; D001262:Atenolol; D003404:Creatinine; D017706:Lisinopril