Effects of clofibrate on salt loading-induced hypertension in rats.
The effects of clofibrate on the hemodynamic and renal manifestations of increased saline intake were analyzed. Four groups of male Wistar rats were treated for five weeks: control, clofibrate (240 mg/kg/day), salt (2% via drinking water), and salt + clofibrate. Body weight, systolic blood pressure (SBP), and heart rate (HR) were recorded weekly. Finally, SBP, HR, and morphologic, metabolic, plasma, and renal variables were measured. Salt increased SBP, HR, urinary isoprostanes, NOx, ET, vasopressin and proteinuria and reduced plasma free T(4) (FT(4)) and tissue FT(4) and FT(3) versus control rats. Clofibrate prevented the increase in SBP produced by salt administration, reduced the sodium balance, and further reduced plasma and tissue thyroid hormone levels. However, clofibrate did not modify the relative cardiac mass, NOx, urinary ET, and vasopressin of saline-loaded rats. In conclusion, chronic clofibrate administration prevented the blood pressure elevation of salt-loaded rats by decreasing sodium balance and reducing thyroid hormone levels.
Cruz
Antonio
A
Departamento de Fisiología, Facultad de Medicina, 18012 Granada, Spain.
Rodríguez-Gómez
Isabel
I
Pérez-Abud
Rocío
R
Vargas
Miguel Ángel
MÁ
Wangensteen
Rosemary
R
Quesada
Andrés
A
Osuna
Antonio
A
Moreno
Juan Manuel
JM
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002994:Clofibrate / Q000494:pharmacology / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017673:Sodium Chloride, Dietary; D013599:Systole / Q000187:drug effects; D013963:Thyroid Hormones / Q000378:metabolism
D000924:Anticholesteremic Agents; D017673:Sodium Chloride, Dietary; D013963:Thyroid Hormones; D002994:Clofibrate