[Multi-modality magnetic resonance imaging features of cognitive function in mild cognitive impairment].
OBJECTIVE
To investigate the association of multi-modality neuroimaging features and cognitive function in mild cognitive impairment (MCI) and Alzheimer's disease (AD).


METHODS
Nine individuals with amnestic MCI (aMCI), fifteen patients with mild probable AD, and eleven age-controlled cognitively normal controls (NC) were recruited. All participants were administered with mini-mental status examination (MMSE) and Cognitive assessment screening instrument (CASI) to assess general cognitive function. Optimized voxel-based morphometry (VBM) was used for the analysis with 3-D high resolution anatomical images. Values of fractional anisotropy (FA) and mean apparent diffusivity coefficient (ADC) were measured from different brain regions on diffusion-tensor images (DTI). The relationship between structural atrophy and DTI-based measurements in the selected brain regions was examined.


RESULTS
The scores of MMSE and CASI were correlated with the volumetric changes in such areas as temporal, frontal and parietal lobes, and cingulate gyrus and hippocampal gyrus (P<0.001). The scores of MMSE and CASI were positively correlated with FA values, and negatively with ADC values in the white-matter-affected regions including temporal, frontal, parietal lobes, cingulate gyrus, and parahippocampal gyrus (P<0.05).


CONCLUSIONS
Cognitive decline was associated with atrophy and white matter microstructural alterations in temporal, frontal, parietal lobes, cingulate gyrus, and parahippocampal gyrus in MCI and AD. Multi-modality imaging technique may be important in elucidating the brain mechanism of cognitive impairment.
Wang
Hua-li
HL
Peking University Institute of Mental Health, Key Laboratory for Mental Health, Ministry of Health, Beijing 100191, China. huali_wang@hsc.pku.edu.cn
Yuan
Hui-shu
HS
Su
Lydia Min-ying
LM
Zhu
Yue
Y
Liao
Jing
J
Zhang
Mei-yan
MY
Li
Tao
T
Yu
Xin
X
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged