title: Superparamagnetic bifunctional bisphosphonates nanoparticles: a potential MRI contrast agent for osteoporosis therapy and diagnostic.
abstract: A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagnetic γFe(2)O(3) nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting. The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment. The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRI T2(∗) contrast agent were demonstrated. Cellular tests performed on human osteosarcoma cells (MG63) show that γFe(2)O(3)@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system.
authors.affiliation: Laboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Lalatonne
authors.forename: M
authors.initials: M
authors.lastname: Monteil
authors.forename: H
authors.initials: H
authors.lastname: Jouni
authors.forename: J M
authors.initials: JM
authors.lastname: Serfaty
authors.forename: O
authors.initials: O
authors.lastname: Sainte-Catherine
authors.forename: N
authors.initials: N
authors.lastname: Lièvre
authors.forename: S
authors.initials: S
authors.lastname: Kusmia
authors.forename: P
authors.initials: P
authors.lastname: Weinmann
authors.forename: M
authors.initials: M
authors.lastname: Lecouvey
authors.forename: L
authors.initials: L
authors.lastname: Motte