SATB1 gene expression and breast cancer prognosis.
Recently it has been shown that the genome organizer SATB1 plays an important role in breast cancer progression and predicts a poor prognosis. However its prognostic value compared to markers as the estrogen receptor is currently unclear. The expression levels of SATB1 mRNA from Affymetrix microarray in a cohort of 2058 breast cancer samples and its prognostic impact were analyzed. There was no significant difference in disease-free survival among ER negative cancers but instead a benefit for high SATB1 expression among ER positive tumors (p = 0.042). However, even in ER positive cancer no independent prognostic value in multivariate analysis with standard parameters was observed. Thus the use of SATB1 as target or prognostic marker for breast cancer should be viewed with caution and a possible confounding effect of the estrogen receptor status of the tumor should be taken into account when analysing new markers as SATB1.
Hanker
Lars C
LC
Department of Obstetrics and Gynecology, J.W. Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany. hanker@med.uni-frankfurt.de
Karn
Thomas
T
Mavrova-Risteska
Loreta
L
Ruckhäberle
Eugen
E
Gaetje
Regine
R
Holtrich
Uwe
U
Kaufmann
Manfred
M
Rody
Achim
A
Wiegratz
Inka
I
D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D005784:Gene Amplification; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics*; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism*; D016019:Survival Analysis
D036961:Matrix Attachment Region Binding Proteins; D011960:Receptors, Estrogen; C076189:SATB1 protein, human