title: Overexpression of piccolo C2A domain induces depression-like behavior in mice.
abstract: Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.
authors.affiliation: Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Furukawa-Hibi
authors.forename: Atsumi
authors.initials: A
authors.lastname: Nitta
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Fukumitsu
authors.forename: Hitomi
authors.initials: H
authors.lastname: Somiya
authors.forename: Shoei
authors.initials: S
authors.lastname: Furukawa
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology; D003866:Depressive Disorder / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009479:Neuropeptides / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology; D010446:Peptide Fragments / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary / Q000235:genetics; D012307:Risk Factors
chemical_list: D003598:Cytoskeletal Proteins; D009479:Neuropeptides; C498631:Pclo protein, mouse; D010446:Peptide Fragments