title: Hypoglycaemic effects of tea extracts and ent-kaurenoic acid from Smallanthus sonchifolius.
abstract: Hypoglycaemic activity was observed in normoglycaemic mice orally administered with the aqueous Smallanthus sonchifolius leaf tea extract, alloxan-induced diabetic mice orally administered with ent-kaurenoic acid (1), and normoglycaemic mice intraperitoneally administered with 1 from S. sonchifolius leaves. A single dose administration of 50 mg kg(-1) BW yacon leaf tea extract demonstrated immediate but relatively short hypoglycaemic activity, with significant effects observed during 1-2 h. Similarly, administration with 100 mg kg(-1) BW yacon leaf tea extract obtained by heavy stirring in hot water demonstrated a more potent activity compared to the positive control at 1.5-2.0 h. Oral administration of 1 did not affect the blood glucose level of the alloxan-induced diabetic mice, but a single intraperitonial injection of 10 mg kg(-1) BW in normoglycaemic mice had consistent percent blood glucose reduction persisting from 1 to 2 h observation periods.
authors.affiliation: Biology Department and Center for Natural Sciences and Ecological Research, De La Salle University, Philippines.
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Raga
authors.forename: Agnes B
authors.initials: AB
authors.lastname: Alimboyoguen
authors.forename: Ramon S
authors.initials: RS
authors.lastname: del Fierro
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001786:Blood Glucose; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D004224:Diterpenes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C051436:kaurenoic acid