Untreated type 2 diabetes and its complications are associated with subcortical infarctions.
OBJECTIVE
To investigate the association of type 2 diabetes with subcortical infarctions.


METHODS
We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging.


RESULTS
The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11-6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects.


CONCLUSIONS
These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.
Roberts
Rosebud O
RO
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. roberts.rosebud@mayo.edu
Kantarci
Kejal
K
Geda
Yonas E
YE
Knopman
David S
DS
Przybelski
Scott A
SA
Weigand
Stephen D
SD
Petersen
Ronald C
RC
Jack
Clifford R
CR
D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000453:epidemiology* / Q000209:etiology; D048909:Diabetes Complications / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male