Post-stroke apathy and hypoperfusion in basal ganglia: SPECT study.
BACKGROUND
Although apathy has been reported as one of the neuropsychiatric symptoms following stroke, there are few studies on regional cerebral blood flow (rCBF) in stroke patients with apathy. The present study compared rCBF between apathetic and non-apathetic patients after stroke.


METHODS
We recruited 102 patients with cerebral infarction within 1 month after stroke and performed neuropsychiatric assessments that included the apathy scale. rCBF was quantitatively measured using N-isopropyl-p-(123)I-iodoamphetamine single-photon emission computed tomography.


RESULTS
Thirty-seven patients (36%) had apathy. The apathetic group showed lower cognitive function and a higher depressive state than the non-apathetic group. rCBF in the basal ganglia was reduced for the apathetic group compared with the non-apathetic group. Furthermore, lesions in the left basal ganglia were associated with hypoperfusion in bilateral basal ganglia and the presence of apathy.


CONCLUSIONS
These findings demonstrate that apathy is a frequent symptom among stroke patients and that hypoperfusion caused by basal ganglia lesions may contribute to post-stroke apathy.
Onoda
Keiichi
K
Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, Japan.
Kuroda
Yoko
Y
Yamamoto
Yasushi
Y
Abe
Satoshi
S
Oguro
Hiroaki
H
Nagai
Atsushi
A
Bokura
Hirokazu
H
Yamaguchi
Shuhei
S
D000368:Aged; D000369:Aged, 80 and over; D057565:Apathy; D001479:Basal Ganglia / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D003071:Cognition; D003863:Depression / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D020367:Iofetamine; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D055420:Perfusion Imaging / Q000379:methods*; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D020367:Iofetamine