title: Connecting chronic and recurrent stress to vascular dysfunction: no relaxed role for the renin-angiotensin system.
abstract: The renin-angiotensin system (RAS) is classically considered to be a protective system for volume balance and is activated during states of volume depletion. Interestingly, one of the major pathways activating the system is the sympathetic nervous system, also the primary mediator of the acute stress response. When one further examines the cells mediating the immune site of the response, which is primarily an inflammatory response leading to defense at a locally injured area, these cells all express the ANG II type 1 receptor (AGTR1). Scattered throughout the literature are reports indicating that acute and chronic stress can activate renin and increase plasma levels of components of the RAS. Moreover, there are reports describing that ANG II can modulate the distribution and function of immune cells. Since the inflammatory response is also implicated to be central in the initiation and progression of vascular damage, we propose in this review that recurrent acute stress and chronic stress can induce a state with inflammation, due to ANG II-mediated activation of inflammatory cells, specifically monocytes and lymphocytes. Such a proposal would explain a lot of the observations regarding RAS components in inflammatory cells. Despite its attractiveness, substantial research in this area would be required to substantiate this hypothesis.
authors.affiliation: Department of Physiology, University of Alberta, and University of Alberta Hospital, Department of Medicine/Division of Nephrology and Immunology, 11-132 CSB Clinical Sciences Bldg., Edmonton, Alberta, Canada T6G 2G3.
authors.forename: Michael
authors.initials: M
authors.lastname: Groeschel
authors.forename: Branko
authors.initials: B
authors.lastname: Braam
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000503:physiopathology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D008214:Lymphocytes / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014652:Vascular Diseases / Q000209:etiology*
chemical_list: D044140:Receptor, Angiotensin, Type 1