[An analysis of efficacy and related factors of itraconazole in the treatment of invasive fungal infection in hematological diseases].
OBJECTIVE
To investigate the effects and related factors of itraconazole in the treatment of invasive fungal infection (IFI) in the patients with blood diseases (BD).


METHODS
A total of 156 BD patients with IFI treated with itraconazole in General Hospital, Tianjin Medical University from 2005 to 2008, were retrospectively analyzed.


RESULTS
Of these patients, 92 were with underlying malignant BD, and 64 with non-malignant BD; 77 possible IFI, and others proven IFI. A total of 94 (63.5%) patients were responded to itraconazole successfully, while 54 (36.5%) failed. The underlying malignant BD, post-chemotherapy, neutrophil count less than 0.5×10(9)/L, positive fungus culture, and bacteria infection were related with the response to itraconazole significantly, while patient's age, application of other antibiotics, positive G test, IFI localization, haemoglobin level and platelet counts were not. Five patients was changed other anti-IFI therapy because of side effects, including gastrointestinal ill (3 cases with nausea or vomiting) and tachycardia (2 cases).


CONCLUSIONS
Itraconazole was effective and safe in the treatment of IFI in the patients with BD. Underlying malignant BD, agranulocytosis, bacteria infection, and delayed anti-IFI therapy might reduce itraconazole therapeutic effects.
Liu
Chun-yan
CY
Hematology Department, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Fu
Rong
R
Wu
Yu-hong
YH
Ruan
Er-bao
EB
Qu
Wen
W
Wang
Guo-jin
GJ
Liang
Yong
Y
Wang
Xiao-ming
XM
Liu
Hong
H
Song
Jia
J
Guan
Jing
J
Wang
Hua-quan
HQ
Xing
Li-min
LM
Li
Li-juan
LJ
Wang
Jun
J
Shao
Zong-hong
ZH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006402:Hematologic Diseases / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D012189:Retrospective Studies; D055815:Young Adult
D000935:Antifungal Agents; D017964:Itraconazole