[Effects of positive end expiratory pressure on pulmonary surfactant in patients undergoing one-lung ventilation].
OBJECTIVE
To evaluate the effect of positive end expiratory pressure on the bronchoalveolar lavage fluid (BALF) in pulmonary surfactant (PS) of patient during one lung ventilation anesthesia.


METHODS
Patients undergoing Bullae resection were anesthetized with treatment (n = 12) or control (n = 12) combined anesthesia. Total phospholipid (TPL), saturated phosphatidylcholine (SatPC) and total protein (TP) in the bronchoalveolar lavage fluid (BALF) were measure. The ratio of SatPC/TPL% and SatPC/TP% represented the activity of PS.


RESULTS
The thoracic surgery pulmonary surfactant significantly reduced, PEEP can prevent the decrease, but with decreased cardiac output.


CONCLUSIONS
The end-expiratory pressure breathing can maintain the level of pulmonary surfactant to protect lung function.
Li
Hong-bin
HB
Department of Anesthesiology, Zhoushan Hospital Zhoushan, Zhoushan 316000, China. lmz1016@126.com
Zhang
Yan
Y
Gao
Bao-bin
BB
Fu
Hai-qing
HQ
Deng
Jiang-hong
JH
D000293:Adolescent; D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D011175:Positive-Pressure Respiration; D011506:Proteins / Q000032:analysis; D011663:Pulmonary Surfactants / Q000378:metabolism*; D055815:Young Adult
D010713:Phosphatidylcholines; D010743:Phospholipids; D011506:Proteins; D011663:Pulmonary Surfactants