Association between circulating specific leukocyte types and blood pressure: the atherosclerosis risk in communities (ARIC) study.
Although total white blood cell (WBC) count has been associated with hypertension, the association between specific WBC types and blood pressure (BP) levels has not been studied. In a cohort of 5746 middle-age African-American and white adults free of clinical cardiovascular disease and cancer and not taking hypertension or anti-inflammatory medications, BP was measured at baseline and 3, 6, and 9 years later. Levels of circulating neutrophils, lymphocytes, and monocytes were measured at baseline. In African-Americans, but much less so in whites, increased neutrophil levels and decreased lymphocyte levels were significantly associated with elevation of BP but did not influence the rate of change of BP over time. The mean BP difference between the highest and lowest quartiles of neutrophils was approximately 8 mm Hg for systolic BP (SBP), 4 mm Hg for mean arterial pressure (MAP), and 5 mm Hg for pulse pressure (PP). The mean BP difference between the lowest and highest quartiles of lymphocytes was approximately 6 mm Hg for SBP, 2 mm Hg for diastolic BP (DBP), 3 mm Hg for MAP, and 4 mm Hg for PP. Increased neutrophils and decreased lymphocytes are significantly correlated with the regulation of BP and the development of hypertension, especially in African-Americans.
Tian
Niu
N
Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. nitan@umc.edu
Penman
Alan D
AD
Mawson
Anthony R
AR
Manning
R Davis
RD
Flessner
Michael F
MF
D000328:Adult; D000368:Aged; D044383:Black People; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D003971:Diastole; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D013599:Systole; D014481:United States; D044465:White People; D001741:Black or African American