title: Right ventricular function in grown-up patients after correction of congenital right heart disease.
abstract: OBJECTIVE
  We investigated whether a correlation exists between biomarkers of the neurohumoral system and clinical markers in grown-up patients with congenital heart disease (GUCH) and right ventricular function.
  
  
  RESULTS
  Prospective, cross-sectional, multicenter study of 104 GUCH patients (median) 16 years (range 6-43 years) after corrective surgery with RV pressure and/or volume overload and 54 healthy controls. Clinical, functional, and laboratory parameters were assessed. Natriuretic peptide levels were significantly increased in GUCH patients (NTproBNP 101 vs. 25 pg/ml, p < 0.001), but we observed no differences in norepinephrine, aldosterone, angiotensin II and Endothelin-1 levels. NTproBNP correlated significantly with clinical markers such as NYHA classification, prolonged QRS duration and reduced exercise capacity (VO(2) peak) (all p < 0.001), as well as self-reported quality of life (p < 0.001). MRI and echocardiography derived RV volumes were elevated and ejection fraction reduced in the patients (both p < 0.001). Tissue Doppler parameter showed significantly restricted ventricular longitudinal systolic function (longitudinal tricuspid valve movement, 1.7 vs. 2.3 cm, p < 0.001), suggesting stiffness and reduced RV compliance.
  
  
  CONCLUSIONS
  In conclusion, grown-up patients with congenital right heart disease NTproBNP correlates well with various clinical markers of RV failure, such as prolongation of QRS duration, exercise capacity, echocardiography and MRI parameters, and quality of life.
authors.affiliation: Deutsches Herzzentrum Berlin, Germany. lemmer@dhm.mhn.de
authors.forename: Julia
authors.initials: J
authors.lastname: Lemmer
authors.forename: Grit
authors.initials: G
authors.lastname: Heise
authors.forename: Axel
authors.initials: A
authors.lastname: Rentzsch
authors.forename: Petra
authors.initials: P
authors.lastname: Boettler
authors.forename: Titus
authors.initials: T
authors.lastname: Kuehne
authors.forename: Karl Otto
authors.initials: KO
authors.lastname: Dubowy
authors.forename: Brigitte
authors.initials: B
authors.lastname: Peters
authors.forename: Bjoern
authors.initials: B
authors.lastname: Lemmer
authors.forename: Alfred
authors.initials: A
authors.lastname: Hager
authors.forename: Brigitte
authors.initials: B
authors.lastname: Stiller
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006330:Heart Defects, Congenital / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011184:Postoperative Period; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D016278:Ventricular Function, Right / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain