Chelidonium majus--an integrative review: traditional knowledge versus modern findings.
Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C. majus as well as purified compounds derived from it exhibit a broad spectrum of biological activities (antiinflammatory, antimicrobial, antitumoral, analgesic, hepatoprotective) that support some of the traditional uses of C. majus. However, herbal medicine also claims that this plant has several important properties which have not yet been scientifically studied: C. majus is supposed to have diuretic, antitussive and eye-regenerative effects. On the other hand, C. majus also has scientifically proven effects, e.g. anti-osteoporotic activity and radioprotection, which are not mentioned in traditional sources. Moreover, recent controversy about the hepatoprotective versus hepatotoxic effects of Chelidonium majus has renewed the interest of the medical community in this plant. This review is intended to integrate traditional ethno-medical knowledge and modern scientific findings about C. majus in order to promote understanding of its therapeutic actions as well as its toxic potential.
Gilca
Marilena
M
Biochemistry Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. marilenagilca@gmail.com
Gaman
Laura
L
Panait
Elena
E
Stoian
Irina
I
Atanasiu
Valeriu
V
D000470:Alkaloids / Q000627:therapeutic use; D000818:Animals; D028281:Chelidonium / Q000737:chemistry; D002648:Child; D005419:Flavonoids / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D051379:Mice; D010636:Phenols / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000627:therapeutic use; D051381:Rats; D014069:Tonsillitis / Q000188:drug therapy
D000470:Alkaloids; D005419:Flavonoids; D010636:Phenols; D028321:Plant Preparations