title: Factors influencing the mechanical behaviour of healthy human descending thoracic aorta.
abstract: In recent times, significant effort has been made to understand the mechanical behaviour of the arterial wall and how it is affected by the different vascular pathologies. However, to be able to interpret the results correctly, it is essential that the influence of other factors, such as aging or anisotropy, be understood. Knowledge of mechanical behaviour of the aorta has been customarily constrained by lack of data on fresh aortic tissue, especially from healthy young individuals. In addition, information regarding the point of rupture is also very limited. In this study, the mechanical behaviour of the descending thoracic aorta of 28 organ donors with no apparent disease, whose ages vary from 17 to 60 years, is evaluated. Tensile tests up to rupture are carried out to evaluate the influence of age and wall anisotropy. Results reveal that the tensile strength and stretch at failure of healthy descending aortas show a significant reduction with age, falling abruptly beyond the age of 30. This fact places age as a key factor when mechanical properties of descending aorta are considered.
authors.affiliation: Departamento de Ciencia de Materiales, E.T.S.I. de Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Madrid, Spain.
authors.forename: Gustavo V
authors.initials: GV
authors.lastname: Guinea
authors.forename: José M
authors.initials: JM
authors.lastname: Atienza
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Rojo
authors.forename: Claudio M
authors.initials: CM
authors.lastname: García-Herrera
authors.forename: Li
authors.initials: L
authors.lastname: Yiqun
authors.forename: Els
authors.initials: E
authors.lastname: Claes
authors.forename: José M
authors.initials: JM
authors.lastname: Goicolea
authors.forename: Carlos
authors.initials: C
authors.lastname: García-Montero
authors.forename: Raúl L
authors.initials: RL
authors.lastname: Burgos
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Goicolea
authors.forename: Manuel
authors.initials: M
authors.lastname: Elices
mesh_terms: D000293:Adolescent; D000328:Adult; D001013:Aorta, Thoracic / Q000502:physiology*; D001696:Biomechanical Phenomena / Q000502:physiology; D004550:Elbow / Q000502:physiology; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013718:Tensile Strength / Q000502:physiology; D055815:Young Adult