title: Obesity induced changes to plasma adiponectin concentration and cholesterol lipoprotein composition profile in cats.
abstract: Feline obesity generally results in aberrations to plasma metabolite levels, such as lipid concentrations and lipoprotein composition. This study sought to investigate the resultant effect of obesity on cholesterol lipoprotein composition and circulating adiponectin concentrations in cats. Plasma glucose, lipids (triglyceride, cholesterol and free fatty acid), insulin and adiponectin concentrations, and cholesterol lipoprotein composition were measured and compared between body condition score (BCS) determined normal healthy control and obese cats. Although the obese group demonstrated higher levels of plasma cholesterol, glucose, and triglycerides, as compared to healthy controls, the difference was insignificant thus indicating that the BCS determined obese cats may have been overweight and not morbidly obese. Plasma insulin levels were significantly higher (25-30%) versus healthy control animals thereby possibly hinting at the ensuing emergence of obesity induced insulin resistance. However, the BCS determined obese cat demonstrated a significant reduction (p<0.05) in plasma adiponectin concentration and a significant increase (p<0.05) in LDL-cholesterol % as compared to age matched healthy control animals. This would indicate that changes in plasma adiponectin concentration and cholesterol lipoprotein composition may be good early indicators of obesity in cats.
authors.affiliation: School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Muranaka
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Hatano
authors.forename: T R
authors.initials: TR
authors.lastname: Saito
authors.forename: P
authors.initials: P
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Kigure
authors.forename: M
authors.initials: M
authors.lastname: Yagishita
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D002371:Cat Diseases / Q000097:blood / Q000378:metabolism*; D002415:Cats; D005260:Female; D008074:Lipoproteins / Q000097:blood* / Q000145:classification* / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism / Q000662:veterinary*
chemical_list: D052242:Adiponectin; D008074:Lipoproteins