Inhibition of nonsense-mediated mRNA decay by antisense morpholino oligonucleotides restores functional expression of hERG nonsense and frameshift mutations in long-QT syndrome.
Gong
Qiuming
Q
Division of Cardiovascular Medicine, Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Stump
Matthew R
MR
Zhou
Zhengfeng
Z
D018389:Codon, Nonsense / Q000235:genetics*; D051638:Ether-A-Go-Go Potassium Channels / Q000235:genetics*; D016368:Frameshift Mutation / Q000235:genetics*; D006801:Humans; D015151:Immunoblotting; D008133:Long QT Syndrome / Q000235:genetics*; D016376:Oligonucleotides, Antisense / Q000235:genetics; D018408:Patch-Clamp Techniques; D034622:RNA Interference; D020871:RNA Stability / Q000235:genetics*
D018389:Codon, Nonsense; D051638:Ether-A-Go-Go Potassium Channels; D016376:Oligonucleotides, Antisense