title: Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function.
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-2035, USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Zanotti-Fregonara
authors.forename: Sami S
authors.initials: SS
authors.lastname: Zoghbi
authors.forename: Jeih-San
authors.initials: JS
authors.lastname: Liow
authors.forename: Elise
authors.initials: E
authors.lastname: Luong
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.forename: Robert L
authors.initials: RL
authors.lastname: Gladding
authors.forename: Victor W
authors.initials: VW
authors.lastname: Pike
authors.forename: Robert B
authors.initials: RB
authors.lastname: Innis
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujita
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000201:enzymology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016018:Least-Squares Analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D017711:Nonlinear Dynamics; D010949:Plasma / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D012015:Reference Standards; D015203:Reproducibility of Results; D020889:Rolipram / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram