Human NK cells require caspases for activation-induced proliferation and cytokine release but not for cytotoxicity.
Ussat
S
S
Institut für Immunologie, Christian-Albrechts-Universität Kiel, Michaelisstrasse 5, Kiel, Germany.
Scherer
G
G
Fazio
J
J
Beetz
S
S
Kabelitz
D
D
Adam-Klages
S
S
D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D015703:Antigens, CD / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism*; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000494:pharmacology; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D037181:Lectins, C-Type / Q000378:metabolism; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D000099192:CD69 Antigens
D000590:Amino Acid Chloromethyl Ketones; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D061945:Caspase Inhibitors; D020169:Caspases; D015853:Cysteine Proteinase Inhibitors; D016207:Cytokines; D006684:HLA-DR Antigens; D007371:Interferon-gamma; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D037181:Lectins, C-Type; D014409:Tumor Necrosis Factor-alpha; D000099192:CD69 Antigens; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone