title: Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells.
authors.affiliation: Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Ariza
authors.forename: Rupal
authors.initials: R
authors.lastname: Ramakrishnan
authors.forename: Narendra P
authors.initials: NP
authors.lastname: Singh
authors.forename: Ashok
authors.initials: A
authors.lastname: Chauhan
authors.forename: Prakash S
authors.initials: PS
authors.lastname: Nagarkatti
authors.forename: Mitzi
authors.initials: M
authors.lastname: Nagarkatti
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D001688:Biological Products / Q000378:metabolism / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000166:cytology; D054713:Bryostatins / Q000378:metabolism* / Q000494:pharmacology*; D018925:Chemokines / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D050838:Interferon Regulatory Factor-3 / Q000235:genetics / Q000378:metabolism; D008024:Ligands; D051379:Mice; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D010641:Phenotype; D011485:Protein Binding; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D015533:Transcriptional Activation / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D054713:Bryostatins; D018925:Chemokines; D050838:Interferon Regulatory Factor-3; D008024:Ligands; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; C046785:bryostatin 1