title: Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
authors.affiliation: Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Oda
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hübner
authors.forename: David B
authors.initials: DB
authors.lastname: Beck
authors.forename: Michiel
authors.initials: M
authors.lastname: Vermeulen
authors.forename: Jerard
authors.initials: J
authors.lastname: Hurwitz
authors.forename: David L
authors.initials: DL
authors.lastname: Spector
authors.forename: Danny
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D000818:Animals; D055162:Biocatalysis / Q000528:radiation effects; D045744:Cell Line, Tumor; D044842:Cullin Proteins / Q000378:metabolism*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004789:Enzyme Activation / Q000528:radiation effects; D004795:Enzyme Stability; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011485:Protein Binding / Q000528:radiation effects; D011499:Protein Processing, Post-Translational / Q000528:radiation effects; D017434:Protein Structure, Tertiary; D016196:S Phase / Q000528:radiation effects; D015398:Signal Transduction / Q000528:radiation effects; D000071857:Tumor Suppressor p53-Binding Protein 1; D025801:Ubiquitin / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: C114234:CUL4A protein, human; C517832:CUL4B protein, human; D044842:Cullin Proteins; C091435:DDB1 protein, human; D004268:DNA-Binding Proteins; C429530:DTL protein, human; D006657:Histones; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; C498301:TP53BP1 protein, human; D000071857:Tumor Suppressor p53-Binding Protein 1; D025801:Ubiquitin; D011495:Histone-Lysine N-Methyltransferase; C470730:KMT5A protein, human; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex