Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
Seimon
Tracie A
TA
Department of Medicine, Columbia University, New York, NY 10032, USA.
Nadolski
Marissa J
MJ
Liao
Xianghai
X
Magallon
Jorge
J
Nguyen
Matthew
M
Feric
Nicole T
NT
Koschinsky
Marlys L
ML
Harkewicz
Richard
R
Witztum
Joseph L
JL
Tsimikas
Sotirios
S
Golenbock
Douglas
D
Moore
Kathryn J
KJ
Tabas
Ira
I
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D017353:Gene Deletion; D017270:Lipoprotein(a) / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000378:metabolism; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism*
D018955:CD36 Antigens; D005227:Fatty Acids; D017270:Lipoprotein(a); D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008562:Membrane Glycoproteins; D010743:Phospholipids; D017382:Reactive Oxygen Species; D051195:Toll-Like Receptor 2; C488842:Cybb protein, mouse; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases