Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease.
Bardag-Gorce
Fawzia
F
Department of Pathology, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. fgorce@labiomed.org
Oliva
Joan
J
Lin
Andrew
A
Li
Jun
J
French
Barbara A
BA
French
Samuel W
SW
D000818:Animals; D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D000431:Ethanol; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D005980:Glutathione Reductase / Q000235:genetics / Q000378:metabolism; D005981:Glutathione Synthase / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism; D061988:Proteasome Inhibitors; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D015854:Up-Regulation / Q000187:drug effects*; D000099156:Superoxide Dismutase 2
D001897:Boronic Acids; D000069286:Bortezomib; D019392:Cytochrome P-450 CYP2E1; D004791:Enzyme Inhibitors; D000431:Ethanol; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005981:Glutathione Synthase; D046988:Proteasome Endopeptidase Complex; D061988:Proteasome Inhibitors; D011719:Pyrazines; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C525844:glutathione peroxidase 2, rat