title: The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A.
authors.affiliation: Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
authors.forename: Tam Luong
authors.initials: TL
authors.lastname: Nguyen
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xu
authors.forename: Rick
authors.initials: R
authors.lastname: Gussio
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Ernest
authors.initials: E
authors.lastname: Hamel
mesh_terms: D000818:Animals; D001665:Binding Sites; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D007783:Lactones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008958:Models, Molecular; D055503:Protein Multimerization / Q000187:drug effects*; D020836:Protein Structure, Quaternary; D013237:Stereoisomerism; D014316:Tritium / Q000737:chemistry*; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D018942:Macrolides; D014404:Tubulin; C117305:laulimalide; C414085:peloruside A; D014316:Tritium