Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect.
Sun
Jing
J
Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065, United States.
Dahan
Arik
A
Walls
Zachary F
ZF
Lai
Longsheng
L
Lee
Kyung-Dall
KD
Amidon
Gordon L
GL
D000577:Amides / Q000737:chemistry / Q000378:metabolism*; D055162:Biocatalysis; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
D000577:Amides; D011355:Prodrugs; C093745:BPHL protein, human; D002265:Carboxylic Ester Hydrolases