Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function.
Zanotti-Fregonara
Paolo
P
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-2035, USA.
Zoghbi
Sami S
SS
Liow
Jeih-San
JS
Luong
Elise
E
Boellaard
Ronald
R
Gladding
Robert L
RL
Pike
Victor W
VW
Innis
Robert B
RB
Fujita
Masahiro
M
D000328:Adult; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000201:enzymology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016018:Least-Squares Analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D017711:Nonlinear Dynamics; D010949:Plasma / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D012015:Reference Standards; D015203:Reproducibility of Results; D020889:Rolipram / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*
D019275:Radiopharmaceuticals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram