title: Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies.
authors.affiliation: Pepscan Therapeutics B.V., Zuidersluisweg 2, 8243 RC Lelystad, The Netherlands. daniele.Altschuh@unistra.fr
authors.forename: Peter
authors.initials: P
authors.lastname: Timmerman
authors.forename: Susana G
authors.initials: SG
authors.lastname: Shochat
authors.forename: Johan
authors.initials: J
authors.lastname: Desmet
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Barderas
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Casal
authors.forename: Rob H
authors.initials: RH
authors.lastname: Meloen
authors.forename: Danièle
authors.initials: D
authors.lastname: Altschuh
mesh_terms: D000595:Amino Acid Sequence; D000906:Antibodies / Q000737:chemistry / Q000378:metabolism*; D000915:Antibody Affinity / Q000502:physiology*; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001666:Binding Sites, Antibody / Q000502:physiology; D022801:Complementarity Determining Regions / Q000737:chemistry* / Q000378:metabolism*; D003198:Computer Simulation; D018604:Epitope Mapping; D005755:Gastrins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009113:Muramidase / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D040081:Protein Array Analysis; D011485:Protein Binding
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D022801:Complementarity Determining Regions; D005755:Gastrins; D007328:Insulin; D010446:Peptide Fragments; D009113:Muramidase