Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells.
Ariza
Maria Eugenia
ME
Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA.
Ramakrishnan
Rupal
R
Singh
Narendra P
NP
Chauhan
Ashok
A
Nagarkatti
Prakash S
PS
Nagarkatti
Mitzi
M
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D001688:Biological Products / Q000378:metabolism / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000166:cytology; D054713:Bryostatins / Q000378:metabolism* / Q000494:pharmacology*; D018925:Chemokines / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D050838:Interferon Regulatory Factor-3 / Q000235:genetics / Q000378:metabolism; D008024:Ligands; D051379:Mice; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D010641:Phenotype; D011485:Protein Binding; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D015533:Transcriptional Activation / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects
D000970:Antineoplastic Agents; D001688:Biological Products; D054713:Bryostatins; D018925:Chemokines; D050838:Interferon Regulatory Factor-3; D008024:Ligands; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; C046785:bryostatin 1