Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.
Zadjali
Fahad
F
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Pike
Ashley C W
AC
Vesterlund
Mattias
M
Sun
Jianmin
J
Wu
Chenggang
C
Li
Shawn S C
SS
Rönnstrand
Lars
L
Knapp
Stefan
S
Bullock
Alex N
AN
Flores-Morales
Amilcar
A
D000595:Amino Acid Sequence; D057809:HEK293 Cells; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010748:Phosphopeptides / Q000378:metabolism; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000737:chemistry / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction; D019089:Stem Cell Factor / Q000378:metabolism; D013379:Substrate Specificity; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000737:chemistry* / Q000378:metabolism*; D054875:Ubiquitination; D018909:src Homology Domains
D010748:Phosphopeptides; C106644:SOCS3 protein, human; C473085:SOCS6 protein, human; D019089:Stem Cell Factor; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D019009:Proto-Oncogene Proteins c-kit; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11