DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.
Cabello
Christopher M
CM
Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Lamore
Sarah D
SD
Bair
Warner B
WB
Davis
Angela L
AL
Azimian
Sara M
SM
Wondrak
Georg T
GT
D015086:2,6-Dichloroindophenol / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D020169:Caspases / Q000378:metabolism; D016923:Cell Death; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004249:DNA Damage; D005260:Female; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D005978:Glutathione / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D015151:Immunoblotting; D053078:Membrane Potential, Mitochondrial; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D034741:RNA, Small Interfering
D000970:Antineoplastic Agents; D006360:Heat-Shock Proteins; D034741:RNA, Small Interfering; D015086:2,6-Dichloroindophenol; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; D020169:Caspases; D005978:Glutathione