title: 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
authors.affiliation: Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. youngshin.cho@novartis
authors.forename: Young Shin
authors.initials: YS
authors.lastname: Cho
authors.forename: Maria
authors.initials: M
authors.lastname: Borland
authors.forename: Christopher
authors.initials: C
authors.lastname: Brain
authors.forename: Christine H-T
authors.initials: CH
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.forename: Rajiv
authors.initials: R
authors.lastname: Chopra
authors.forename: Kristy
authors.initials: K
authors.lastname: Chung
authors.forename: James
authors.initials: J
authors.lastname: Groarke
authors.forename: Guo
authors.initials: G
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Hou
authors.forename: Sunkyu
authors.initials: S
authors.lastname: Kim
authors.forename: Steven
authors.initials: S
authors.lastname: Kovats
authors.forename: Yipin
authors.initials: Y
authors.lastname: Lu
authors.forename: Marc
authors.initials: M
authors.lastname: O'Reilly
authors.forename: Junqing
authors.initials: J
authors.lastname: Shen
authors.forename: Troy
authors.initials: T
authors.lastname: Smith
authors.forename: Gary
authors.initials: G
authors.lastname: Trakshel
authors.forename: Markus
authors.initials: M
authors.lastname: Vögtle
authors.forename: Mei
authors.initials: M
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Moo Je
authors.initials: MJ
authors.lastname: Sung
mesh_terms: D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D051358:Cyclin-Dependent Kinase 4 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D051361:Cyclin-Dependent Kinase 6 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D057166:High-Throughput Screening Assays; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles; D011743:Pyrimidines; D051358:Cyclin-Dependent Kinase 4; D051361:Cyclin-Dependent Kinase 6