Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
Denk
Gerald U
GU
Department of Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany.
Maitz
Silvia
S
Wimmer
Ralf
R
Rust
Christian
C
Invernizzi
Pietro
P
Ferdinandusse
Sacha
S
Kulik
Wim
W
Fuchsbichler
Andrea
A
Fickert
Peter
P
Trauner
Michael
M
Hofmann
Alan F
AF
Beuers
Ulrich
U
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002761:Cholangitis / Q000188:drug therapy; D002779:Cholestasis / Q000139:chemically induced*; D002849:Chromatography, Gas; D018197:Hepatoblastoma / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000209:etiology*; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000378:metabolism; D013658:Taurolithocholic Acid / Q000009:adverse effects*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D001647:Bile Acids and Salts; D013654:Taurine; D013658:Taurolithocholic Acid; D014580:Ursodeoxycholic Acid