title: Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia.
authors.affiliation: Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, the Netherlands. f.e.vandenboogaard@amc.uva.nl
authors.forename: F E
authors.initials: FE
authors.lastname: Van Den Boogaard
authors.forename: X
authors.initials: X
authors.lastname: Brands
authors.forename: M J
authors.initials: MJ
authors.lastname: Schultz
authors.forename: M
authors.initials: M
authors.lastname: Levi
authors.forename: J J T H
authors.initials: JJ
authors.lastname: Roelofs
authors.forename: C
authors.initials: C
authors.lastname: Van 't Veer
authors.forename: T
authors.initials: T
authors.lastname: Van Der Poll
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002443:Ceftriaxone / Q000494:pharmacology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008074:Lipoproteins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011018:Pneumonia, Pneumococcal / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D011994:Recombinant Proteins / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D018836:Inflammation Mediators; D008074:Lipoproteins; D011994:Recombinant Proteins; C051928:lipoprotein-associated coagulation inhibitor; D002443:Ceftriaxone