title: Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK.
authors.affiliation: Global Research and Development, Pfizer Inc., San Diego, CA 92121, USA. sptanis@sbcglobal.net
authors.forename: Steven P
authors.initials: SP
authors.lastname: Tanis
authors.forename: Michael B
authors.initials: MB
authors.lastname: Plewe
authors.forename: Ted W
authors.initials: TW
authors.lastname: Johnson
authors.forename: Scott L
authors.initials: SL
authors.lastname: Butler
authors.forename: Deepak
authors.initials: D
authors.lastname: Dalvie
authors.forename: Dorothy
authors.initials: D
authors.lastname: DeLisle
authors.forename: Klaus R
authors.initials: KR
authors.lastname: Dress
authors.forename: Qiyue
authors.initials: Q
authors.lastname: Hu
authors.forename: Buwen
authors.initials: B
authors.lastname: Huang
authors.forename: Jon E
authors.initials: JE
authors.lastname: Kuehler
authors.forename: Atsuo
authors.initials: A
authors.lastname: Kuki
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Peng
authors.forename: Graham L
authors.initials: GL
authors.lastname: Smith
authors.forename: Jim
authors.initials: J
authors.lastname: Solowiej
authors.forename: Khanh T
authors.initials: KT
authors.lastname: Tran
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.forename: Anle
authors.initials: A
authors.lastname: Yang
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Yin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yu
authors.forename: Junhu
authors.initials: J
authors.lastname: Zhang
authors.forename: Huichun
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D019427:HIV Integrase / Q000737:chemistry* / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D015497:HIV-1 / Q000201:enzymology*; D006207:Half-Life; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D007211:Indoles / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D019428:HIV Integrase Inhibitors; D006877:Hydroxamic Acids; D007211:Indoles; C030374:indole; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1