title: PDK1 plays a critical role in regulating cardiac function in mice and human.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Ruo-min
authors.initials: RM
authors.lastname: Di
authors.forename: Qiu-ting
authors.initials: QT
authors.lastname: Feng
authors.forename: Zai
authors.initials: Z
authors.lastname: Chang
authors.forename: Qing
authors.initials: Q
authors.lastname: Luan
authors.forename: Yang-yang
authors.initials: YY
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Xin-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Zhong-zhou
authors.initials: ZZ
authors.lastname: Yang
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases; D000328:Adult; D000818:Animals; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000201:enzymology / Q000209:etiology; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008875:Middle Aged; D018995:Myosin Heavy Chains / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015398:Signal Transduction; D013629:Tamoxifen / Q000494:pharmacology
chemical_list: D013629:Tamoxifen; D064413:3-Phosphoinositide-Dependent Protein Kinases; C578562:PDPK1 protein, human; C578564:Pdpk1 protein, mouse; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D018995:Myosin Heavy Chains