title: Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17177 Stockholm, Sweden.
authors.forename: Fahad
authors.initials: F
authors.lastname: Zadjali
authors.forename: Ashley C W
authors.initials: AC
authors.lastname: Pike
authors.forename: Mattias
authors.initials: M
authors.lastname: Vesterlund
authors.forename: Jianmin
authors.initials: J
authors.lastname: Sun
authors.forename: Chenggang
authors.initials: C
authors.lastname: Wu
authors.forename: Shawn S C
authors.initials: SS
authors.lastname: Li
authors.forename: Lars
authors.initials: L
authors.lastname: Rönnstrand
authors.forename: Stefan
authors.initials: S
authors.lastname: Knapp
authors.forename: Alex N
authors.initials: AN
authors.lastname: Bullock
authors.forename: Amilcar
authors.initials: A
authors.lastname: Flores-Morales
mesh_terms: D000595:Amino Acid Sequence; D057809:HEK293 Cells; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010748:Phosphopeptides / Q000378:metabolism; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000737:chemistry / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction; D019089:Stem Cell Factor / Q000378:metabolism; D013379:Substrate Specificity; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000737:chemistry* / Q000378:metabolism*; D054875:Ubiquitination; D018909:src Homology Domains
chemical_list: D010748:Phosphopeptides; C106644:SOCS3 protein, human; C473085:SOCS6 protein, human; D019089:Stem Cell Factor; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D019009:Proto-Oncogene Proteins c-kit; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11