The Siah2-HIF-FoxA2 axis in prostate cancer – new markers  and therapeutic opportunities.
Qi
Jianfei
J
Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
Pellecchia
Maurizio
M
Ronai
Ze'ev A
ZA
D000230:Adenocarcinoma / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015195:Drug Design; D015972:Gene Expression Regulation, Neoplastic; D051542:Hepatocyte Nuclear Factor 3-beta / Q000378:metabolism*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008297:Male; D058990:Molecular Targeted Therapy; D018358:Neuroendocrine Tumors / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D000098563:Seven in Absentia Proteins
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C496502:FOXA2 protein, human; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D051542:Hepatocyte Nuclear Factor 3-beta; D044767:Ubiquitin-Protein Ligases; D000098563:Seven in Absentia Proteins