title: Antinociceptive effect of spirocyclopiperazinium salt compound LXM-15 via activating peripheral α7 nAChR and M4 mAChR in mice.
authors.affiliation: Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: Jia
authors.initials: J
authors.lastname: Ye
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Yulan
authors.initials: Y
authors.lastname: Xiong
authors.forename: Runtao
authors.initials: R
authors.lastname: Li
authors.forename: Yimin
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D043588:Receptor, Muscarinic M4 / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013141:Spiro Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: D000700:Analgesics; C579166:Chrna7 protein, mouse; C579165:Chrna7 protein, rat; D010879:Piperazines; D043588:Receptor, Muscarinic M4; D011978:Receptors, Nicotinic; D013141:Spiro Compounds; D064569:alpha7 Nicotinic Acetylcholine Receptor