Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(II) complexes with DNA, causing significant alterations to the DNA helix.
Sanchez-Cano
Carlos
C
School of Chemistry, University of Birmingham, Birmingham, UK.
Huxley
Martin
M
Ducani
Cosimo
C
Hamad
Amal E
AE
Browning
Michael J
MJ
Navarro-Ranninger
Carmen
C
Quiroga
Adoracion G
AG
Rodger
Alison
A
Hannon
Michael J
MJ
D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D010984:Platinum / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013739:Testosterone / Q000737:chemistry*
D056831:Coordination Complexes; D013739:Testosterone; D010984:Platinum; D004247:DNA