The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
Chen
Hung-Yi
HY
Schools of Pharmacy, China Medical University, Taichung, Taiwan, ROC.
Lu
Hsu-Feng
HF
Yang
Jai-Sing
JS
Kuo
Sheng-Chu
SC
Lo
Chyi
C
Yang
Mei-Due
MD
Chiu
Tsan-Hung
TH
Chueh
Fu-Shin
FS
Ho
Heng-Chien
HC
Ko
Yang-Ching
YC
Chung
Jing-Gung
JG
D048948:14-3-3 Proteins / Q000096:biosynthesis / Q000235:genetics; D064007:Ataxia Telangiectasia Mutated Proteins; D019313:BRCA1 Protein / Q000096:biosynthesis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000235:genetics; D018797:Cell Cycle Proteins / Q000096:biosynthesis / Q000235:genetics; D045744:Cell Line, Tumor; D020552:Comet Assay; D004249:DNA Damage; D053938:DNA Fragmentation / Q000187:drug effects; D015254:DNA Modification Methylases / Q000096:biosynthesis / Q000235:genetics; D004260:DNA Repair / Q000187:drug effects* / Q000235:genetics; D045643:DNA Repair Enzymes / Q000096:biosynthesis / Q000235:genetics; D051747:DNA-Activated Protein Kinase / Q000096:biosynthesis / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D004149:Dioxoles / Q000494:pharmacology*; D005092:Exonucleases / Q000096:biosynthesis / Q000235:genetics; D005095:Exoribonucleases; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology*; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis / Q000235:genetics
D048948:14-3-3 Proteins; C525063:2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone; D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D004149:Dioxoles; D015363:Quinolones; D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; C576324:ATM protein, human; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human; D045643:DNA Repair Enzymes