title: Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity.
authors.affiliation: Mitochondrial Research Group, Institute of Human Genetics, Newcastle University, UK.
authors.forename: Joanna D
authors.initials: JD
authors.lastname: Stewart
authors.forename: Rita
authors.initials: R
authors.lastname: Horvath
authors.forename: Enrico
authors.initials: E
authors.lastname: Baruffini
authors.forename: Iliana
authors.initials: I
authors.lastname: Ferrero
authors.forename: Stefanie
authors.initials: S
authors.lastname: Bulst
authors.forename: Paul B
authors.initials: PB
authors.lastname: Watkins
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Fontana
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Day
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Chinnery
mesh_terms: D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D001714:Bipolar Disorder / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000235:genetics; D018682:GABA Agents / Q000009:adverse effects / Q000627:therapeutic use; D014644:Genetic Variation; D006261:Headache / Q000188:drug therapy; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012640:Seizures / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D018682:GABA Agents; D014635:Valproic Acid; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase; C413027:POLG protein, human