Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia.
Van Den Boogaard
F E
FE
Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, the Netherlands. f.e.vandenboogaard@amc.uva.nl
Brands
X
X
Schultz
M J
MJ
Levi
M
M
Roelofs
J J T H
JJ
Van 't Veer
C
C
Van Der Poll
T
T
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002443:Ceftriaxone / Q000494:pharmacology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008074:Lipoproteins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011018:Pneumonia, Pneumococcal / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D011994:Recombinant Proteins / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D018836:Inflammation Mediators; D008074:Lipoproteins; D011994:Recombinant Proteins; C051928:lipoprotein-associated coagulation inhibitor; D002443:Ceftriaxone