title: Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways.
authors.affiliation: Center for Immunochemistry, Veterans Affairs Medical Center, San Francisco, CA, 94121, USA.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Liu
authors.forename: Constance M
authors.initials: CM
authors.lastname: John
authors.forename: Gary A
authors.initials: GA
authors.lastname: Jarvis
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism* / Q000502:physiology; D018122:B7-1 Antigen / Q000096:biosynthesis; D002460:Cell Line; D006801:Humans; D050856:Interferon Regulatory Factor-1 / Q000096:biosynthesis; D050838:Interferon Regulatory Factor-3 / Q000502:physiology; D008050:Lipid A / Q000737:chemistry / Q000502:physiology*; D008070:Lipopolysaccharides / Q000737:chemistry / Q000502:physiology*; D051218:Lymphocyte Antigen 96 / Q000378:metabolism / Q000502:physiology*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism* / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology; D009344:Neisseria gonorrhoeae / Q000737:chemistry* / Q000276:immunology; D009345:Neisseria meningitidis / Q000737:chemistry* / Q000276:immunology; D010766:Phosphorylation / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000378:metabolism / Q000502:physiology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D018122:B7-1 Antigen; C494232:IRF3 protein, human; D050856:Interferon Regulatory Factor-1; D050838:Interferon Regulatory Factor-3; C495377:LY96 protein, human; D008050:Lipid A; D008070:Lipopolysaccharides; D051218:Lymphocyte Antigen 96; C507779:MYD88 protein, human; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; C470409:TICAM1 protein, human; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; C023023:lipid-linked oligosaccharides