Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.
Buchholz
Tonia J
TJ
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Rath
Christopher M
CM
Lopanik
Nicole B
NB
Gardner
Noah P
NP
Håkansson
Kristina
K
Sherman
David H
DH
D000213:Acyl Carrier Protein / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D054713:Bryostatins / Q000096:biosynthesis*; D020134:Catalytic Domain; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity; D020349:Surface Plasmon Resonance
D000213:Acyl Carrier Protein; D054713:Bryostatins; C046785:bryostatin 1; D006904:Hydroxymethylglutaryl-CoA Synthase