The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A.
Nguyen
Tam Luong
TL
Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
Xu
Xiaoming
X
Gussio
Rick
R
Ghosh
Arun K
AK
Hamel
Ernest
E
D000818:Animals; D001665:Binding Sites; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D007783:Lactones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008958:Models, Molecular; D055503:Protein Multimerization / Q000187:drug effects*; D020836:Protein Structure, Quaternary; D013237:Stereoisomerism; D014316:Tritium / Q000737:chemistry*; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D018942:Macrolides; D014404:Tubulin; C117305:laulimalide; C414085:peloruside A; D014316:Tritium