PKCalpha/beta I inhibitor Go6976 induces dephosphorylation of constitutively hyperphosphorylated Rb and G1 arrest in T24 cells.
Aaltonen
V
V
University of Turku, Department of Ophthalmology, Turku, Finland.
Peltonen
J
J
D002227:Carbazoles / Q000494:pharmacology*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D016193:G1 Phase / Q000187:drug effects*; D016158:Genes, p53; D006801:Humans; D016200:Maturation-Promoting Factor / Q000378:metabolism; D009154:Mutation; D010766:Phosphorylation / Q000187:drug effects; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D064546:Protein Kinase C beta; D051571:Protein Kinase C-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D016160:Retinoblastoma Protein / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D002227:Carbazoles; D047428:Protein Kinase Inhibitors; D016160:Retinoblastoma Protein; C081021:Go 6976; D011493:Protein Kinase C; D064546:Protein Kinase C beta; D051571:Protein Kinase C-alpha; D016200:Maturation-Promoting Factor