title: Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.
authors.affiliation: Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Québec, Canada. lianhai_li@merck.com
authors.forename: Lianhai
authors.initials: L
authors.lastname: Li
authors.forename: Christian
authors.initials: C
authors.lastname: Beaulieu
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Carriere
authors.forename: Danielle
authors.initials: D
authors.lastname: Denis
authors.forename: Gillian
authors.initials: G
authors.lastname: Greig
authors.forename: Daniel
authors.initials: D
authors.lastname: Guay
authors.forename: Gary
authors.initials: G
authors.lastname: O'Neill
authors.forename: Robert
authors.initials: R
authors.lastname: Zamboni
authors.forename: Zhaoyin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C511202:2,3,4,9-tetrahydro-1H-carbazole; D002227:Carbazoles; D011982:Receptors, Prostaglandin; D013450:Sulfones; C501562:prostanoid D receptor 1, human