title: Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.
authors.affiliation: Department of Applied Biology and Chemical Technology and Lo Ka Chung Centre for Natural Anti-Cancer Drug Development, The Hong Kong, China.
authors.forename: Tin-Lun
authors.initials: TL
authors.lastname: Lam
authors.forename: Gabriel K Y
authors.initials: GK
authors.lastname: Wong
authors.forename: Ho-Yin
authors.initials: HY
authors.lastname: Chow
authors.forename: Hiu-Chi
authors.initials: HC
authors.lastname: Chong
authors.forename: Tsz-Lung
authors.initials: TL
authors.lastname: Chow
authors.forename: Sui-Yi
authors.initials: SY
authors.lastname: Kwok
authors.forename: Paul N M
authors.initials: PN
authors.lastname: Cheng
authors.forename: Denys N
authors.initials: DN
authors.lastname: Wheatley
authors.forename: Wai-Hung
authors.initials: WH
authors.lastname: Lo
authors.forename: Yun-Chung
authors.initials: YC
authors.lastname: Leung
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001119:Arginase / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002986:Clinical Trials as Topic; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays; D048490:raf Kinases / Q000037:antagonists & inhibitors
chemical_list: D011994:Recombinant Proteins; D048490:raf Kinases; D001119:Arginase