Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.
Jelinek
David
D
Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM, USA.
Millward
Veronica
V
Birdi
Amandip
A
Trouard
Theodore P
TP
Heidenreich
Randall A
RA
Garver
William S
WS
D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001786:Blood Glucose; D001835:Body Weight / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000473:pathology; D057895:Haploinsufficiency / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D000077296:Niemann-Pick C1 Protein; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000235:genetics*
D001786:Blood Glucose; D007328:Insulin; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D000077296:Niemann-Pick C1 Protein; C106831:Npc1 protein, mouse; D011506:Proteins; D014280:Triglycerides; D002784:Cholesterol