title: Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes.
authors.affiliation: Chinese Academy of Medical Sciences, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Pang
authors.forename: Huan
authors.initials: H
authors.lastname: Gong
authors.forename: Chao
authors.initials: C
authors.lastname: Xi
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.forename: Yang
authors.initials: Y
authors.lastname: Dai
authors.forename: Tie-Mei
authors.initials: TM
authors.lastname: Zhang
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D005947:Glucose / Q000633:toxicity*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D010616:Phenanthrenes / Q000494:pharmacology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism*; D014162:Transfection
chemical_list: C434926:N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride; D010616:Phenanthrenes; D017382:Reactive Oxygen Species; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D055372:AMP-Activated Protein Kinases; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D005947:Glucose