Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.
Gibbs
Alan C
AC
Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477, USA.
Abad
Marta C
MC
Zhang
Xuqing
X
Tounge
Brett A
BA
Lewandowski
Francis A
FA
Struble
Geoffrey T
GT
Sun
Weimei
W
Sui
Zhihua
Z
Kuo
Lawrence C
LC
D000818:Animals; D018938:Caco-2 Cells; D002463:Cell Membrane Permeability; D018360:Crystallography, X-Ray; D004583:Electrons; D005631:Fructokinases / Q000037:antagonists & inhibitors*; D006801:Humans; D066298:In Vitro Techniques; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
D007191:Indazoles; C554507:N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide; D010880:Piperidines; D005631:Fructokinases; C021475:ketohexokinase