Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors.
Perdonà
Elisabetta
E
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Medicines Research Centre, 37135 Verona, Italy. Elisabetta.Perdona@aptuit.com
Faggioni
Federico
F
Buson
Alberto
A
Sabbatini
Fabio Maria
FM
Corti
Corrado
C
Corsi
Mauro
M
D000595:Amino Acid Sequence; D000818:Animals; D053961:Azabicyclo Compounds / Q000494:pharmacology*; D016367:Baculoviridae / Q000235:genetics; D002118:Calcium / Q000378:metabolism; D045744:Cell Line, Tumor; D005786:Gene Expression Regulation; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology*; D007295:Inositol Phosphates / Q000378:metabolism; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D054440:Receptors, Ghrelin / Q000037:antagonists & inhibitors* / Q000235:genetics*
D053961:Azabicyclo Compounds; D006834:Hydrazines; D007295:Inositol Phosphates; C556802:N'-(3,5-bis(trifluoromethyl)phenyl)-2-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-2-(3-pyridinyl)ethanohydrazide; D011758:Pyrroles; D054440:Receptors, Ghrelin; D002118:Calcium