Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig.
Armstead
William M
WM
Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA. armsteaw@uphs.upenn.edu
Ganguly
Kumkum
K
Riley
John
J
Kiessling
J Willis
JW
Cines
Douglas B
DB
Higazi
Abd A R
AA
Zaitsev
Sergei
S
Muzykantov
Vladimir R
VR
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000098:blood supply*; D004912:Erythrocytes / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D011446:Prospective Studies; D011897:Random Allocation; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*; D016781:Toxoplasmosis, Cerebral / Q000503:physiopathology*; D014664:Vasodilation / Q000187:drug effects*; D048051:p38 Mitogen-Activated Protein Kinases / Q000187:drug effects*
D048031:JNK Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D010959:Tissue Plasminogen Activator