title: Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy.
authors.affiliation: Department of Medicinal Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA. kobporn_howell@merck.com
authors.forename: Kobporn L
authors.initials: KL
authors.lastname: Howell
authors.forename: Robert J
authors.initials: RJ
authors.lastname: DeVita
authors.forename: Margarita
authors.initials: M
authors.lastname: Garcia-Calvo
authors.forename: Roger D
authors.initials: RD
authors.lastname: Meurer
authors.forename: JeanMarie
authors.initials: J
authors.lastname: Lisnock
authors.forename: Herbert G
authors.initials: HG
authors.lastname: Bull
authors.forename: Daniel R
authors.initials: DR
authors.lastname: McMasters
authors.forename: Margaret E
authors.initials: ME
authors.lastname: McCann
authors.forename: Sander G
authors.initials: SG
authors.lastname: Mills
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001384:Azetidines; D000069438:Ezetimibe; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects; D026901:Membrane Transport Proteins / Q000187:drug effects*; D051379:Mice; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D007093:Imidazoles; D026901:Membrane Transport Proteins; C482445:Npc1l1 protein, mouse; D013141:Spiro Compounds; D000069438:Ezetimibe