Effects on molecular conformation and anticoagulant activities of 1,6-anhydrosugars at the reducing terminal of antithrombin-binding octasaccharides isolated from low-molecular-weight heparin enoxaparin.
Guerrini
Marco
M
G. Ronzoni Institute for Chemical and Biochemical Research, via G. Colombo 81, 20133 Milan, Italy.
Elli
Stefano
S
Gaudesi
Davide
D
Torri
Giangiacomo
G
Casu
Benito
B
Mourier
Pierre
P
Herman
Frederic
F
Boudier
Christian
C
Lorenz
Martin
M
Viskov
Christian
C
D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D058833:Antithrombin Proteins / Q000737:chemistry* / Q000378:metabolism; D002240:Carbohydrate Sequence; D017984:Enoxaparin / Q000737:chemistry*; D015951:Factor Xa / Q000737:chemistry; D065427:Factor Xa Inhibitors; D006595:Hexosamines / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011485:Protein Binding; D013329:Structure-Activity Relationship
D000925:Anticoagulants; D058833:Antithrombin Proteins; D017984:Enoxaparin; D065427:Factor Xa Inhibitors; D006595:Hexosamines; D009844:Oligosaccharides; D015951:Factor Xa