title: UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation.
authors.affiliation: Centro de Pesquisas em Biologia Molecular e Funcional, Instituto Nacional de Ciência e Tecnologia em Tuberculose, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Diana C
authors.initials: DC
authors.lastname: Rostirolla
authors.forename: Ardala
authors.initials: A
authors.lastname: Breda
authors.forename: Leonardo A
authors.initials: LA
authors.lastname: Rosado
authors.forename: Mario S
authors.initials: MS
authors.lastname: Palma
authors.forename: Luiz A
authors.initials: LA
authors.lastname: Basso
authors.forename: Diógenes S
authors.initials: DS
authors.lastname: Santos
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D016153:Genes, Suppressor; D006160:Guanosine Triphosphate / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011743:Pyrimidines / Q000378:metabolism*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D021241:Spectrometry, Mass, Electrospray Ionization; D014166:Transferases / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D014544:Uridine Triphosphate / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D008024:Ligands; D011743:Pyrimidines; C078379:pyrH protein, E coli; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D014166:Transferases; C030986:pyrimidine; D014544:Uridine Triphosphate