title: Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2.
authors.affiliation: Incyte Corporation, Experimental Station E336, Wilmington, DE 19880, USA. cxue@incyte.com
authors.forename: Chu-Biao
authors.initials: CB
authors.lastname: Xue
authors.forename: Anlai
authors.initials: A
authors.lastname: Wang
authors.forename: David
authors.initials: D
authors.lastname: Meloni
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Kong
authors.forename: Hao
authors.initials: H
authors.lastname: Feng
authors.forename: Joseph
authors.initials: J
authors.lastname: Glenn
authors.forename: Taisheng
authors.initials: T
authors.lastname: Huang
authors.forename: Yingxin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ganfeng
authors.initials: G
authors.lastname: Cao
authors.forename: Rajan
authors.initials: R
authors.lastname: Anand
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zheng
authors.forename: Michael
authors.initials: M
authors.lastname: Xia
authors.forename: Qi
authors.initials: Q
authors.lastname: Han
authors.forename: D J
authors.initials: DJ
authors.lastname: Robinson
authors.forename: Lou
authors.initials: L
authors.lastname: Storace
authors.forename: Lixin
authors.initials: L
authors.lastname: Shao
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Carrie M
authors.initials: CM
authors.lastname: Brodmerkel
authors.forename: Maryanne
authors.initials: M
authors.lastname: Covington
authors.forename: Peggy
authors.initials: P
authors.lastname: Scherle
authors.forename: Sharon
authors.initials: S
authors.lastname: Diamond
authors.forename: Swamy
authors.initials: S
authors.lastname: Yeleswaram
authors.forename: Kris
authors.initials: K
authors.lastname: Vaddi
authors.forename: Robert
authors.initials: R
authors.lastname: Newton
authors.forename: Greg
authors.initials: G
authors.lastname: Hollis
authors.forename: Steven
authors.initials: S
authors.lastname: Friedman
authors.forename: Brian
authors.initials: B
authors.lastname: Metcalf
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D011485:Protein Binding; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D054390:Receptors, CCR2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C505875:INCB3344; D011759:Pyrrolidines; D054390:Receptors, CCR2