A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.
Wu
Ning
N
Institute of Medicinal Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
Wu
Xi-Wei
XW
Agama
Keli
K
Pommier
Yves
Y
Du
Jun
J
Li
Ding
D
Gu
Lian-Quan
LQ
Huang
Zhi-Shu
ZS
An
Lin-Kun
LK
D002166:Camptothecin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D006801:Humans; D007212:Indolizines / Q000494:pharmacology*; D020014:K562 Cells; D015363:Quinolones / Q000494:pharmacology*; D059004:Topoisomerase I Inhibitors / Q000494:pharmacology*
D007212:Indolizines; D015363:Quinolones; D059004:Topoisomerase I Inhibitors; C554566:ethyl 7-fluoro-5,12-dioxo-5,12-dihydroindolizino(2,3-g)quinoline-6-carboxylate; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin