title: Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.
authors.affiliation: Alliance for Cellular Signaling, Northern California Institute for Research and Education, University of California, Veterans Affairs Medical Center, San Francisco, California 94121, USA. rarebres@yahoo.com
authors.forename: Robert A
authors.initials: RA
authors.lastname: Rebres
authors.forename: Tamara I A
authors.initials: TI
authors.lastname: Roach
authors.forename: Iain D C
authors.initials: ID
authors.lastname: Fraser
authors.forename: Finly
authors.initials: F
authors.lastname: Philip
authors.forename: Christina
authors.initials: C
authors.lastname: Moon
authors.forename: Keng-Mean
authors.initials: KM
authors.lastname: Lin
authors.forename: Jamie
authors.initials: J
authors.lastname: Liu
authors.forename: Leah
authors.initials: L
authors.lastname: Santat
authors.forename: Lucas
authors.initials: L
authors.lastname: Cheadle
authors.forename: Elliott M
authors.initials: EM
authors.lastname: Ross
authors.forename: Melvin I
authors.initials: MI
authors.lastname: Simon
authors.forename: William E
authors.initials: WE
authors.lastname: Seaman
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D015936:Complement C5a / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism*; D044387:GTP-Binding Protein beta Subunits / Q000378:metabolism*; D044388:GTP-Binding Protein gamma Subunits / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D016296:Mutagenesis; D041681:NIH 3T3 Cells; D054799:Phospholipase C beta / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D014530:Uridine Diphosphate / Q000378:metabolism
chemical_list: D044387:GTP-Binding Protein beta Subunits; D044388:GTP-Binding Protein gamma Subunits; D034741:RNA, Small Interfering; D018048:Receptors, Purinergic P2; D014530:Uridine Diphosphate; D015936:Complement C5a; C518039:PLCB3 protein, human; D054799:Phospholipase C beta; C518034:Plcb1 protein, mouse; C518037:Plcb2 protein, mouse; C518040:Plcb3 protein, mouse; C518043:Plcb4 protein, mouse; D043802:GTP-Binding Protein alpha Subunits, Gq-G11