Role and mechanism of uncoupling protein 2 on the fatty acid-induced dysfunction of pancreatic alpha cells in vitro.
Su
Jie-ying
JY
Graduate School, Peking Union Medical College, Tsinghua University, Beijing 100730, China.
Li
Hong-liang
HL
Yang
Wen-ying
WY
Xiao
Jian-zhong
JZ
Du
Rui-qin
RQ
Shen
Xiao-xia
XX
Cai
Zhe
Z
Zhang
Lan
L
Shu
Jun
J
D000818:Animals; D002478:Cells, Cultured; D005934:Glucagon / Q000378:metabolism; D050416:Glucagon-Secreting Cells / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000494:pharmacology; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D007473:Ion Channels / Q000235:genetics / Q000502:physiology*; D057889:Iridoid Glycosides / Q000494:pharmacology; D039823:Iridoids; D051379:Mice; D024101:Mitochondrial Proteins / Q000235:genetics / Q000502:physiology*; D018384:Oxidative Stress; D019308:Palmitic Acid / Q000633:toxicity*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010766:Phosphorylation; D012333:RNA, Messenger / Q000032:analysis; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism; D000071246:Uncoupling Protein 2
D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D007473:Ion Channels; D057889:Iridoid Glycosides; D039823:Iridoids; C526295:Irs1 protein, mouse; D024101:Mitochondrial Proteins; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; C000604390:Ucp2 protein, mouse; D000071246:Uncoupling Protein 2; D019308:Palmitic Acid; C002744:3-nitrotyrosine; D014443:Tyrosine; D005934:Glucagon; C007834:genipin