title: A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
authors.affiliation: Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Department of Microbiology and Immunology, University of California-San Francisco, California, USA.
authors.forename: Byron B
authors.initials: BB
authors.lastname: Au-Yeung
authors.forename: Susan E
authors.initials: SE
authors.lastname: Levin
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Lih-Yun
authors.initials: LY
authors.lastname: Hsu
authors.forename: Debra A
authors.initials: DA
authors.lastname: Cheng
authors.forename: Nigel
authors.initials: N
authors.lastname: Killeen
authors.forename: Kevan M
authors.initials: KM
authors.lastname: Shokat
authors.forename: Arthur
authors.initials: A
authors.lastname: Weiss
mesh_terms: D000818:Animals; D055162:Biocatalysis; D049109:Cell Proliferation / Q000187:drug effects; D002469:Cell Separation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005434:Flow Cytometry; D015151:Immunoblotting; D047468:Immunoprecipitation; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000201:enzymology* / Q000276:immunology; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000378:metabolism*
chemical_list: C108123:4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine; D004791:Enzyme Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D011948:Receptors, Antigen, T-Cell; D051746:ZAP-70 Protein-Tyrosine Kinase; C497262:Zap70 protein, mouse