Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.
Pecchi
Sabina
S
Novartis Institutes for Biomedical Research, Emeryville, CA, USA. sabina.pecchi@novartis.com
Renhowe
Paul A
PA
Taylor
Clarke
C
Kaufman
Susan
S
Merritt
Hanne
H
Wiesmann
Marion
M
Shoemaker
Kevin R
KR
Knapp
Mark S
MS
Ornelas
Elizabeth
E
Hendrickson
Thomas F
TF
Fantl
Wendy
W
Voliva
Charles F
CF
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009025:Morpholines / Q000737:chemistry / Q000494:pharmacology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009025:Morpholines; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines