Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.
Leong
David T
DT
Cancer Science Institute of Singapore, National University of Singapore, Singapore. csiltwd@nus.edu.sg
Lim
Joleen
J
Goh
Xuewei
X
Pratap
Jitesh
J
Pereira
Barry P
BP
Kwok
Hui Si
HS
Nathan
Saminathan Suresh
SS
Dobson
Jason R
JR
Lian
Jane B
JB
Ito
Yoshiaki
Y
Voorhoeve
P Mathijs
PM
Stein
Gary S
GS
Salto-Tellez
Manuel
M
Cool
Simon M
SM
van Wijnen
Andre J
AJ
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000037:antagonists & inhibitors; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020935:MAP Kinase Signaling System; D009362:Neoplasm Metastasis; D010006:Osteoblasts / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering
D014408:Biomarkers, Tumor; D050659:Core Binding Factor Alpha 1 Subunit; D005419:Flavonoids; D034741:RNA, Small Interfering; C493709:RUNX2 protein, human; D048049:Extracellular Signal-Regulated MAP Kinases; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one