The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
Yu
Ji Hoon
JH
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Zhu
Bing-Mei
BM
Wickre
Mark
M
Riedlinger
Gregory
G
Chen
Weiping
W
Hosui
Atsushi
A
Robinson
Gertraud W
GW
Hennighausen
Lothar
L
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D002453:Cell Cycle; D002455:Cell Division; D050764:Cyclin-Dependent Kinase Inhibitor p19 / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006706:Homeostasis; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000235:genetics; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D020411:Oligonucleotide Array Sequence Analysis; D050799:STAT5 Transcription Factor / Q000172:deficiency / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics
C493957:Cdkn1a protein, mouse; C493975:Cdkn2d protein, mouse; D050764:Cyclin-Dependent Kinase Inhibitor p19; D050759:Cyclin-Dependent Kinase Inhibitor p21; D050799:STAT5 Transcription Factor; C494093:Stat5a protein, mouse; C494096:Stat5b protein, mouse; D025521:Tumor Suppressor Proteins; D002251:Carbon Tetrachloride