title: Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.
authors.affiliation: Novartis Institutes for Biomedical Research, Emeryville, CA, USA. sabina.pecchi@novartis.com
authors.forename: Sabina
authors.initials: S
authors.lastname: Pecchi
authors.forename: Paul A
authors.initials: PA
authors.lastname: Renhowe
authors.forename: Clarke
authors.initials: C
authors.lastname: Taylor
authors.forename: Susan
authors.initials: S
authors.lastname: Kaufman
authors.forename: Hanne
authors.initials: H
authors.lastname: Merritt
authors.forename: Marion
authors.initials: M
authors.lastname: Wiesmann
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Shoemaker
authors.forename: Mark S
authors.initials: MS
authors.lastname: Knapp
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ornelas
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Hendrickson
authors.forename: Wendy
authors.initials: W
authors.lastname: Fantl
authors.forename: Charles F
authors.initials: CF
authors.lastname: Voliva
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009025:Morpholines / Q000737:chemistry / Q000494:pharmacology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009025:Morpholines; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines