Selective inhibition of early--but not late--expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage.
Yeh
Shiu-Hwa
SH
Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Ou
Li-Chin
LC
Gean
Po-Wu
PW
Hung
Jan-Jong
JJ
Chang
Wen-Chang
WC
D000077584:2-Methoxyestradiol; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology*; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D020868:Gene Silencing; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000378:metabolism*; D034741:RNA, Small Interfering; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000150:complications / Q000473:pathology; D013997:Time Factors
D000963:Antimetabolites; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D018696:Neuroprotective Agents; D034741:RNA, Small Interfering; D004958:Estradiol; D000077584:2-Methoxyestradiol