Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action.
Smith
Karen
K
Department of Chemistry and Centre for Biomedical Research, University of Hull, Kingston-upon-Hull, UK.
Malatesti
Nela
N
Cauchon
Nicole
N
Hunting
Darel
D
Lecomte
Roger
R
van Lier
Johan E
JE
Greenman
John
J
Boyle
Ross W
RW
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D016923:Cell Death; D045744:Cell Line, Tumor / Q000528:radiation effects; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy; D017323:Dihematoporphyrin Ether / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D039663:Integrin beta4 / Q000276:immunology; D017879:Isothiocyanates / Q000737:chemistry; D008027:Light; D051379:Mice; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D018796:Immunoconjugates; D039663:Integrin beta4; D017879:Isothiocyanates; D017319:Photosensitizing Agents; D011166:Porphyrins; C037152:isothiocyanic acid; D017323:Dihematoporphyrin Ether