Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.
Lam
Tin-Lun
TL
Department of Applied Biology and Chemical Technology and Lo Ka Chung Centre for Natural Anti-Cancer Drug Development, The Hong Kong, China.
Wong
Gabriel K Y
GK
Chow
Ho-Yin
HY
Chong
Hiu-Chi
HC
Chow
Tsz-Lung
TL
Kwok
Sui-Yi
SY
Cheng
Paul N M
PN
Wheatley
Denys N
DN
Lo
Wai-Hung
WH
Leung
Yun-Chung
YC
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001119:Arginase / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002986:Clinical Trials as Topic; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays; D048490:raf Kinases / Q000037:antagonists & inhibitors
D011994:Recombinant Proteins; D048490:raf Kinases; D001119:Arginase