A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells.
Wang
Fei
F
School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China.
Zhai
Shumei
S
Liu
Xiaojun
X
Li
Liwen
L
Wu
Shirley
S
Dou
Q Ping
QP
Yan
Bing
B
D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D003300:Copper / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D061988:Proteasome Inhibitors; D011759:Pyrrolidines / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D061988:Proteasome Inhibitors; D011759:Pyrrolidines; D013859:Thiocarbamates; C020972:pyrrolidine dithiocarbamic acid; D003300:Copper; D000444:Aldehyde Dehydrogenase