Reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-mexiletine prepared by microwave irradiation with four new chiral derivatizing reagents based on trichloro-s-triazine having amino acids as chiral auxiliaries and 10 others having amino acid amides.
Bhushan
Ravi
R
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. rbushfcy@iitr.ernet.in
Dixit
Shuchi
S
D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D056148:Chromatography, Reverse-Phase / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D016014:Linear Models; D008801:Mexiletine / Q000737:chemistry* / Q000302:isolation & purification; D008872:Microwaves; D015203:Reproducibility of Results; D013237:Stereoisomerism; D014227:Triazines / Q000737:chemistry*
D000577:Amides; D000596:Amino Acids; D014227:Triazines; D008801:Mexiletine; C019309:cyanuric chloride