title: Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action.
authors.affiliation: Department of Chemistry and Centre for Biomedical Research, University of Hull, Kingston-upon-Hull, UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Smith
authors.forename: Nela
authors.initials: N
authors.lastname: Malatesti
authors.forename: Nicole
authors.initials: N
authors.lastname: Cauchon
authors.forename: Darel
authors.initials: D
authors.lastname: Hunting
authors.forename: Roger
authors.initials: R
authors.lastname: Lecomte
authors.forename: Johan E
authors.initials: JE
authors.lastname: van Lier
authors.forename: John
authors.initials: J
authors.lastname: Greenman
authors.forename: Ross W
authors.initials: RW
authors.lastname: Boyle
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D016923:Cell Death; D045744:Cell Line, Tumor / Q000528:radiation effects; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy; D017323:Dihematoporphyrin Ether / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D039663:Integrin beta4 / Q000276:immunology; D017879:Isothiocyanates / Q000737:chemistry; D008027:Light; D051379:Mice; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D018796:Immunoconjugates; D039663:Integrin beta4; D017879:Isothiocyanates; D017319:Photosensitizing Agents; D011166:Porphyrins; C037152:isothiocyanic acid; D017323:Dihematoporphyrin Ether