2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
Jonckers
Tim H M
TH
Tibotec BVBA, A Division of Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium. tjoncker@its.jnj.com
Lin
Tse-I
TI
Buyck
Christophe
C
Lachau-Durand
Sophie
S
Vandyck
Koen
K
Van Hoof
Steven
S
Vandekerckhove
Leen A M
LA
Hu
Lili
L
Berke
Jan Martin
JM
Vijgen
Leen
L
Dillen
Lieve L A
LL
Cummings
Maxwell D
MD
de Kock
Herman
H
Nilsson
Magnus
M
Sund
Christian
C
Rydegård
Christina
C
Samuelsson
Bertil
B
Rosenquist
Asa
A
Fanning
Gregory
G
Van Emelen
Kristof
K
Simmen
Kenneth
K
Raboisson
Pierre
P
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004285:Dogs; D004952:Esters; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D008297:Male; D008958:Models, Molecular; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D014779:Virus Replication
C554513:2'-deoxy-2'-spirocyclopropylcytidine; D000998:Antiviral Agents; D004952:Esters; D011355:Prodrugs; D013141:Spiro Compounds; D017361:Viral Nonstructural Proteins; D003562:Cytidine; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase