Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.
Krug
Martin
M
Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Germany.
Erlenkamp
German
G
Sippl
Wolfgang
W
Schächtele
Christoph
C
Totzke
Frank
F
Hilgeroth
Andreas
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001596:Benzylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003198:Computer Simulation; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D011485:Protein Binding; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001596:Benzylamines; D020794:Receptor Protein-Tyrosine Kinases; D017526:Receptor, IGF Type 1