Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.
Wang
Yue
Y
Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University Medical School, China.
Huang
Zhou-Qing
ZQ
Wang
Chang-Qian
CQ
Wang
Lian-Sheng
LS
Meng
Shu
S
Zhang
Ya-Chen
YC
Chen
Ting
T
Fan
Yu-Qi
YQ
D000890:Anti-Infective Agents / Q000494:pharmacology; D037621:Artemisinins / Q000494:pharmacology*; D051926:Basigin / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D051745:Protein Kinase C-delta / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism / Q000502:physiology*
D000890:Anti-Infective Agents; D037621:Artemisinins; C497886:BSG protein, human; D061965:Matrix Metalloproteinase Inhibitors; D051926:Basigin; C031327:artemisinin; D051745:Protein Kinase C-delta; D048049:Extracellular Signal-Regulated MAP Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D020780:Matrix Metalloproteinase 9; D013755:Tetradecanoylphorbol Acetate