Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.
Li
Lianhai
L
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Québec, Canada. lianhai_li@merck.com
Beaulieu
Christian
C
Carriere
Marie-Claude
MC
Denis
Danielle
D
Greig
Gillian
G
Guay
Daniel
D
O'Neill
Gary
G
Zamboni
Robert
R
Wang
Zhaoyin
Z
D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
C511202:2,3,4,9-tetrahydro-1H-carbazole; D002227:Carbazoles; D011982:Receptors, Prostaglandin; D013450:Sulfones; C501562:prostanoid D receptor 1, human