Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease.
Koprich
James B
JB
Toronto Western Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada. jkoprich@uhnres.utoronto.ca.
Johnston
Tom H
TH
Reyes
M Gabriela
MG
Sun
Xuan
X
Brotchie
Jonathan M
JM