Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions.
Zhang
Xi-Chun
XC
Departments of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess, Medical Center and Harvard Medical School, Boston, MA 02115, USA.
Kainz
Vanessa
V
Burstein
Rami
R
Levy
Dan
D
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D004195:Disease Models, Animal; D004388:Dura Mater / Q000166:cytology / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006930:Hyperalgesia / Q000139:chemically induced* / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010812:Physical Stimulation / Q000009:adverse effects; D011720:Pyrazoles / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D012668:Trigeminal Ganglion / Q000166:cytology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
D004791:Enzyme Inhibitors; D007093:Imidazoles; D008565:Membrane Proteins; D011720:Pyrazoles; D011725:Pyridines; D047888:Receptors, Tumor Necrosis Factor, Type I; C115461:SC 560; D014409:Tumor Necrosis Factor-alpha; D051545:Cyclooxygenase 1; C496513:Ptgs1 protein, rat; D048051:p38 Mitogen-Activated Protein Kinases; C093642:SB 203580