Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.
Zhang
Jing
J
Department of Biological Sciences, National University of Singapore, Singapore.
Yang
Lifeng
L
Ang
Zhiwei
Z
Yoong
Sia Lee
SL
Tran
Thi Thu Thuy
TT
Anand
Ganesh Srinivasan
GS
Tan
Nguan Soon
NS
Ho
Bow
B
Ding
Jeak Ling
JL
D000138:Acidosis / Q000097:blood / Q000378:metabolism; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism* / Q000502:physiology; D019556:COS Cells; D002460:Cell Line; D002522:Chlorocebus aethiops; D004927:Escherichia coli Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D016209:Interleukin-8 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D037102:Lectins / Q000172:deficiency / Q000378:metabolism*; D046911:Macromolecular Substances / Q000097:blood / Q000378:metabolism; D008565:Membrane Proteins / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D009000:Monocytes / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D011552:Pseudomonas Infections / Q000097:blood / Q000276:immunology / Q000378:metabolism; D020239:Receptor Cross-Talk / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D012480:Salmonella Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology; D015398:Signal Transduction / Q000276:immunology*; D013203:Staphylococcal Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology; D020298:U937 Cells; D015854:Up-Regulation / Q000276:immunology; D000097604:Ficolins; D043562:Receptors, G-Protein-Coupled
D002097:C-Reactive Protein; D016209:Interleukin-8; D037102:Lectins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D000097604:Ficolins; C473103:FFAR2 protein, human; D043562:Receptors, G-Protein-Coupled