PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes.
Rohani
Maryam G
MG
Department of Medicine/Dermatology, University of Washington, Seattle, WA 98195-6524, USA.
DiJulio
Dennis H
DH
An
Jonathan Y
JY
Hacker
Beth M
BM
Dale
Beverly A
BA
Chung
Whasun O
WO
D002478:Cells, Cultured; D054418:Chemokine CCL20 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D054365:Chemokine CXCL5 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D019743:Chemokines, CXC / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D015536:Down-Regulation; D006801:Humans; D007113:Immunity, Innate; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D009055:Mouth / Q000473:pathology; D010518:Periodontitis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D044463:Receptor, PAR-1 / Q000276:immunology / Q000378:metabolism*; D044464:Receptor, PAR-2 / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
C499707:CXCL3 protein, human; D054418:Chemokine CCL20; D054365:Chemokine CXCL5; D019743:Chemokines, CXC; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D048052:Mitogen-Activated Protein Kinase 3; D048051:p38 Mitogen-Activated Protein Kinases