Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatment.
Capriles
Priscila V S Z
PV
Grupo de Modelagem Molecular de Sistemas Biológicos, Laboratório Nacional de Computação Científica, LNCC/MCT, Petrópolis, CEP 25651-075, Brazil. capriles@lncc.br
Guimarães
Ana C R
AC
Otto
Thomas D
TD
Miranda
Antonio B
AB
Dardenne
Laurent E
LE
Degrave
Wim M
WM
D015094:3-Hydroxyacyl CoA Dehydrogenases / Q000378:metabolism; D000595:Amino Acid Sequence; D000977:Antiparasitic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D030562:Databases, Protein; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D040681:Structural Homology, Protein; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
D000977:Antiparasitic Agents; D015800:Protozoan Proteins; D015094:3-Hydroxyacyl CoA Dehydrogenases