Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.
Kay
Hee Yeon
HY
Innovative Drug Research Center for Metabolic and Inflammatory Diseases, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Sillimdong, Kwanak-gu, Seoul, Korea.
Kim
Young Woo
YW
Ryu
Da Hye
DH
Sung
Sang Hyun
SH
Hwang
Se Jin
SJ
Kim
Sang Geon
SG
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004149:Dioxoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D056945:Hep G2 Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051267:NF-E2-Related Factor 2 / Q000502:physiology*; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051745:Protein Kinase C-delta / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D032134:Saururaceae; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D033921:Vesicular Transport Proteins
D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D001578:Benzopyrans; D004149:Dioxoles; D017705:Lignans; D051267:NF-E2-Related Factor 2; D028321:Plant Preparations; D020011:Protective Agents; D011506:Proteins; D033921:Vesicular Transport Proteins; C485462:Vps52 protein, mouse; C410958:sauchinone; D000082:Acetaminophen; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D051745:Protein Kinase C-delta; D038362:Glycogen Synthase Kinase 3; D005978:Glutathione