5-amino-pyrazoles as potent and selective p38α inhibitors.
Das
Jagabandhu
J
Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. jagabandhu.das@bms.com
Moquin
Robert V
RV
Dyckman
Alaric J
AJ
Li
Tianle
T
Pitt
Sidney
S
Zhang
Rosemary
R
Shen
Ding Ren
DR
McIntyre
Kim W
KW
Gillooly
Kathleen
K
Doweyko
Arthur M
AM
Newitt
John A
JA
Sack
John S
JS
Zhang
Hongjian
H
Kiefer
Susan E
SE
Kish
Kevin
K
McKinnon
Murray
M
Barrish
Joel C
JC
Dodd
John H
JH
Schieven
Gary L
GL
Leftheris
Katerina
K
D000818:Animals; D018360:Crystallography, X-Ray; D051379:Mice; D048308:Mitogen-Activated Protein Kinase 14 / Q000037:antagonists & inhibitors / Q000737:chemistry*; D011485:Protein Binding; D011487:Protein Conformation; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D014409:Tumor Necrosis Factor-alpha; D048308:Mitogen-Activated Protein Kinase 14