Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death.
Herrmann
Alexander M
AM
Department of Neurology-Inflammatory Disorders of the Nervous System and Neurooncology, University of Münster, Domagkstr. 13, 48149 Münster, Germany.
Göbel
Kerstin
K
Simon
Ole J
OJ
Melzer
Nico
N
Schuhmann
Michael K
MK
Stenner
Max-Philipp
MP
Weishaupt
Andreas
A
Kleinschnitz
Christoph
C
Bittner
Stefan
S
Meuth
Patrick
P
Stuve
Olaf
O
Budde
Thomas
T
Kieseier
Bernd C
BC
Wiendl
Heinz
H
Meuth
Sven G
SG
D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D019610:Cytoprotection / Q000187:drug effects / Q000276:immunology; D015536:Down-Regulation / Q000187:drug effects / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D004622:Embryo, Mammalian; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000068717:Glatiramer Acetate; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018836:Inflammation Mediators / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009474:Neurons / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D055647:Rats, Transgenic; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D018836:Inflammation Mediators; D010455:Peptides; D000068717:Glatiramer Acetate