title: Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.
authors.affiliation: Department of Pharmacology, UT Southwestern Medical Center, ND8.136B, Dallas, Texas 75390-9041, United States.
authors.forename: Keith T
authors.initials: KT
authors.lastname: Gagnon
authors.forename: Hannah M
authors.initials: HM
authors.lastname: Pendergraff
authors.forename: Glen F
authors.initials: GF
authors.lastname: Deleavey
authors.forename: Eric E
authors.initials: EE
authors.lastname: Swayze
authors.forename: Pierre
authors.initials: P
authors.lastname: Potier
authors.forename: John
authors.initials: J
authors.lastname: Randolph
authors.forename: Eric B
authors.initials: EB
authors.lastname: Roesch
authors.forename: Jyoti
authors.initials: J
authors.lastname: Chattopadhyaya
authors.forename: Masad J
authors.initials: MJ
authors.lastname: Damha
authors.forename: C Frank
authors.initials: CF
authors.lastname: Bennett
authors.forename: Christophe
authors.initials: C
authors.lastname: Montaillier
authors.forename: Marc
authors.initials: M
authors.lastname: Lemaitre
authors.forename: David R
authors.initials: DR
authors.lastname: Corey
mesh_terms: D000483:Alleles; D002460:Cell Line; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000188:drug therapy / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics*; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics*; D009841:Oligonucleotides / Q000235:genetics / Q000494:pharmacology; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use; D054735:Phosphorothioate Oligonucleotides / Q000494:pharmacology; D016914:Ribonuclease H / Q000378:metabolism; D013329:Structure-Activity Relationship; D019680:Trinucleotide Repeat Expansion / Q000187:drug effects
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D054735:Phosphorothioate Oligonucleotides; C477371:locked nucleic acid; D016914:Ribonuclease H