Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin.
Chang
Wei-Chuan
WC
Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Hartshorn
Kevan L
KL
White
Mitchell R
MR
Moyo
Patience
P
Michelow
Ian C
IC
Koziel
Henry
H
Kinane
Bernard T
BT
Schmidt
Emmett V
EV
Fujita
Teizo
T
Takahashi
Kazue
K
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D003167:Complement Activation; D037582:Complement Pathway, Mannose-Binding Lectin / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006387:Hemagglutination, Viral / Q000187:drug effects; D009980:Influenza A virus / Q000737:chemistry / Q000187:drug effects*; D037102:Lectins / Q000737:chemistry / Q000494:pharmacology*; D037601:Mannose-Binding Lectin / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000494:pharmacology*; D000097604:Ficolins
D000998:Antiviral Agents; D037102:Lectins; D037601:Mannose-Binding Lectin; D009439:Neuraminidase; D011993:Recombinant Fusion Proteins; D000097604:Ficolins