Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival.
Wu
Yue
Y
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Chhipa
Rishi Raj
RR
Cheng
Jinrong
J
Zhang
Haitao
H
Mohler
James L
JL
Ip
Clement
C
D000726:Androgen Antagonists / Q000494:pharmacology; D000813:Anilides / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000502:physiology; D015536:Down-Regulation; D055785:Gene Knockdown Techniques; D005947:Glucose / Q000172:deficiency; D006801:Humans; D008297:Male; D009570:Nitriles / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics; D020239:Receptor Cross-Talk; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013739:Testosterone / Q000172:deficiency / Q000378:metabolism* / Q000494:pharmacology; D014105:Tosyl Compounds / Q000494:pharmacology; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis
D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D034741:RNA, Small Interfering; D011944:Receptors, Androgen; C000624650:TSC1 protein, human; C000624653:TSC2 protein, human; D014105:Tosyl Compounds; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; D013739:Testosterone; C053541:bicalutamide; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D005947:Glucose; D020123:Sirolimus