title: The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers.
authors.affiliation: Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, D820, 44 Binney Street, Boston, MA 02115, USA.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Okuda
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: James
authors.initials: J
authors.lastname: Butrynski
authors.forename: Marzia
authors.initials: M
authors.lastname: Capelletti
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Nathanael S
authors.initials: NS
authors.lastname: Gray
authors.forename: Keith
authors.initials: K
authors.lastname: Wilner
authors.forename: James G
authors.initials: JG
authors.lastname: Christensen
authors.forename: George
authors.initials: G
authors.lastname: Demetri
authors.forename: Geoffrey I
authors.initials: GI
authors.lastname: Shapiro
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Rodig
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Eck
authors.forename: Pasi A
authors.initials: PA
authors.lastname: Jänne
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002460:Cell Line; D000077547:Crizotinib; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D009154:Mutation; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D009447:Neuroblastoma / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics*; D011720:Pyrazoles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic
chemical_list: C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases