title: TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
authors.affiliation: Genome Damage and Stability Centre, Science Park Road, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zeng
authors.forename: Felipe
authors.initials: F
authors.lastname: Cortés-Ledesma
authors.forename: Sherif F
authors.initials: SF
authors.lastname: El Khamisy
authors.forename: Keith W
authors.initials: KW
authors.lastname: Caldecott
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004249:DNA Damage; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000172:deficiency / Q000378:metabolism*; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000172:deficiency / Q000378:metabolism*
chemical_list: D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D005047:Etoposide; D010727:Phosphoric Diester Hydrolases; C122147:tyrosyl-DNA phosphodiesterase; D004250:DNA Topoisomerases, Type II