Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Hare
Stephen
S
Division of Infectious Diseases, Imperial College London, London W2 1PG, United Kingdom.
Vos
Ann M
AM
Clayton
Reginald F
RF
Thuring
Jan W
JW
Cummings
Maxwell D
MD
Cherepanov
Peter
P
D019943:Amino Acid Substitution / Q000235:genetics; D020134:Catalytic Domain; D024882:Drug Resistance, Viral / Q000235:genetics*; D019143:Evolution, Molecular; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics; D020128:Inhibitory Concentration 50; D019426:Integrases / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology; D000068898:Raltegravir Potassium; D012190:Retroviridae / Q000201:enzymology*
D019428:HIV Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D019426:Integrases