In-vitro permeability screening of melt extrudate formulations containing poorly water-soluble drug compounds using the phospholipid vesicle-based barrier.
Kanzer
Johanna
J
Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø, Norway.
Tho
Ingunn
I
Flaten
Gøril Eide
GE
Mägerlein
Markus
M
Hölig
Peter
P
Fricker
Gert
G
Brandl
Martin
M
D018938:Caco-2 Cells; D002118:Calcium; D002368:Castor Oil; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004058:Diffusion; D004304:Dosage Forms; D017097:Electric Impedance; D005079:Excipients; D005452:Fluoresceins / Q000737:chemistry; D005615:Freezing; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008274:Magnesium; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents; D014867:Water
D004304:Dosage Forms; D005079:Excipients; D005452:Fluoresceins; D004364:Pharmaceutical Preparations; D010743:Phospholipids; D013501:Surface-Active Agents; D014867:Water; D002368:Castor Oil; D008274:Magnesium; D002118:Calcium; C007740:fluorexon