title: Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
authors.affiliation: Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kitada
authors.forename: John L
authors.initials: JL
authors.lastname: Stebbins
authors.forename: William
authors.initials: W
authors.lastname: Placzek
authors.forename: Dayong
authors.initials: D
authors.lastname: Zhai
authors.forename: Bainan
authors.initials: B
authors.lastname: Wu
authors.forename: Michele F
authors.initials: MF
authors.lastname: Rega
authors.forename: Ziming
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jason
authors.initials: J
authors.lastname: Cellitti
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Russell
authors.initials: R
authors.lastname: Dahl
authors.forename: John C
authors.initials: JC
authors.lastname: Reed
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pellecchia
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004355:Drug Stability; D005260:Female; D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D008861:Microsomes / Q000378:metabolism; D008958:Models, Molecular; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009368:Neoplasm Transplantation; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors* / Q000235:genetics; D051381:Rats; D013329:Structure-Activity Relationship; D014183:Transplantation, Heterologous
chemical_list: C554508:6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-methylphenethyl)-2,2'-binaphthyl-1,1',4,4'-tetraone; D000970:Antineoplastic Agents; C474007:Bax protein (53-86); D009285:Naphthoquinones; D010446:Peptide Fragments; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C534401:apogossypolone; D006072:Gossypol