title: Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477, USA.
authors.forename: Alan C
authors.initials: AC
authors.lastname: Gibbs
authors.forename: Marta C
authors.initials: MC
authors.lastname: Abad
authors.forename: Xuqing
authors.initials: X
authors.lastname: Zhang
authors.forename: Brett A
authors.initials: BA
authors.lastname: Tounge
authors.forename: Francis A
authors.initials: FA
authors.lastname: Lewandowski
authors.forename: Geoffrey T
authors.initials: GT
authors.lastname: Struble
authors.forename: Weimei
authors.initials: W
authors.lastname: Sun
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sui
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Kuo
mesh_terms: D000818:Animals; D018938:Caco-2 Cells; D002463:Cell Membrane Permeability; D018360:Crystallography, X-Ray; D004583:Electrons; D005631:Fructokinases / Q000037:antagonists & inhibitors*; D006801:Humans; D066298:In Vitro Techniques; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D007191:Indazoles; C554507:N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide; D010880:Piperidines; D005631:Fructokinases; C021475:ketohexokinase