title: The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.
authors.affiliation: Laboratory of Gene Technology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 21 Box 2462, Leuven B-3001, Belgium.
authors.forename: Wesley
authors.initials: W
authors.lastname: Mattheus
authors.forename: Joleen
authors.initials: J
authors.lastname: Masschelein
authors.forename: Ling-Jie
authors.initials: LJ
authors.lastname: Gao
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
authors.forename: Bart
authors.initials: B
authors.lastname: Landuyt
authors.forename: Guido
authors.initials: G
authors.lastname: Volckaert
authors.forename: Rob
authors.initials: R
authors.lastname: Lavigne
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002219:Carbamates; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D054889:Fatty Acid Synthase, Type II; D005227:Fatty Acids / Q000096:biosynthesis; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D008969:Molecular Sequence Data; D009876:Operon; D009930:Organic Chemicals / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002219:Carbamates; D029968:Escherichia coli Proteins; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D009930:Organic Chemicals; D020033:Protein Isoforms; C088306:batumin; C099201:kalimantacin A; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); C493924:fabI protein, E coli; D054889:Fatty Acid Synthase, Type II