Gamma-secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines.
Okuhashi
Yuki
Y
Department of Laboratory Medicine, Tokyo Medical and Dental University, Bunkyo-Ku, Tokyo, Japan.
Itoh
Mai
M
Arai
Ayako
A
Nara
Nobuo
N
Tohda
Shuji
S
D000368:Aged; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D051792:Basic Helix-Loop-Helix Proteins / Q000096:biosynthesis / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects*; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D004151:Dipeptides / Q000494:pharmacology; D041905:Erythroid Cells / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D015870:Gene Expression / Q000187:drug effects; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology; D011480:Protease Inhibitors / Q000494:pharmacology*; D000072056:Transcription Factor HES-1
D053829:Amyloid Precursor Protein Secretases; D051792:Basic Helix-Loop-Helix Proteins; D004151:Dipeptides; D018398:Homeodomain Proteins; D011480:Protease Inhibitors; D000072056:Transcription Factor HES-1; C419410:N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester; C523463:benzyloxycarbonyl-isoleucyl-leucinal; C078493:HES1 protein, human