title: Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives.
authors.affiliation: Shanghai Hengrui Pharmaceuticals Co., Ltd., 279 Wenjing Road, Shanghai 200245, China.
authors.forename: Tang Peng
authors.initials: TP
authors.lastname: Cho
authors.forename: Su Yi
authors.initials: SY
authors.lastname: Dong
authors.forename: Feng
authors.initials: F
authors.lastname: Jun
authors.forename: Fu Jian
authors.initials: FJ
authors.lastname: Hong
authors.forename: Yang Jiang
authors.initials: YJ
authors.lastname: Liang
authors.forename: Xiao
authors.initials: X
authors.lastname: Lu
authors.forename: Peng Jiang
authors.initials: PJ
authors.lastname: Hua
authors.forename: Li Ya
authors.initials: LY
authors.lastname: Li
authors.forename: Zhang
authors.initials: Z
authors.lastname: Lei
authors.forename: Hu
authors.initials: H
authors.lastname: Bing
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ying
authors.forename: Li Fang
authors.initials: LF
authors.lastname: Qiong
authors.forename: Fu Bei
authors.initials: FB
authors.lastname: Bei
authors.forename: Lou Li
authors.initials: LL
authors.lastname: Guang
authors.forename: Gong Ai
authors.initials: GA
authors.lastname: Shen
authors.forename: She Gao
authors.initials: SG
authors.lastname: Hong
authors.forename: Sun Wei
authors.initials: SW
authors.lastname: Hong
authors.forename: Mong Xian
authors.initials: MX
authors.lastname: Tai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D009368:Neoplasm Transplantation; D019009:Proto-Oncogene Proteins c-kit / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D019009:Proto-Oncogene Proteins c-kit; D017479:Receptors, Platelet-Derived Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor