title: Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner--a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2.
authors.affiliation: Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University Mainz, Augustusplatz 2, Mainz, Germany. koch@mkg.klinik.uni-mainz.de
authors.forename: Felix Peter
authors.initials: FP
authors.lastname: Koch
authors.forename: Christina
authors.initials: C
authors.lastname: Merkel
authors.forename: Bilal
authors.initials: B
authors.lastname: Al-Nawas
authors.forename: Ralf
authors.initials: R
authors.lastname: Smeets
authors.forename: Thomas
authors.initials: T
authors.lastname: Ziebart
authors.forename: Christian
authors.initials: C
authors.lastname: Walter
authors.forename: Wilfried
authors.initials: W
authors.lastname: Wagner
mesh_terms: D015415:Biomarkers / Q000032:analysis; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000187:drug effects; D004002:Clodronic Acid / Q000494:pharmacology; D050659:Core Binding Factor Alpha 1 Subunit / Q000032:analysis*; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects; D018398:Homeodomain Proteins / Q000032:analysis*; D006801:Humans; D000077557:Ibandronic Acid; D007093:Imidazoles / Q000494:pharmacology; D051957:MSX1 Transcription Factor / Q000032:analysis*; D010006:Osteoblasts / Q000187:drug effects*; D015675:Osteocalcin / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014157:Transcription Factors / Q000032:analysis*; D000077211:Zoledronic Acid
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D050659:Core Binding Factor Alpha 1 Subunit; C100596:DLX5 protein, human; D004164:Diphosphonates; D018398:Homeodomain Proteins; D007093:Imidazoles; D051957:MSX1 Transcription Factor; C484083:MSX1 protein, human; C084119:MSX2 protein; C493709:RUNX2 protein, human; D014157:Transcription Factors; D004002:Clodronic Acid; D015675:Osteocalcin; D000077211:Zoledronic Acid; D000077557:Ibandronic Acid