Side chain cyclization based on serine residues: synthesis, structure, and activity of a novel cyclic analogue of the parathyroid hormone fragment 1-11.
Caporale
Andrea
A
Department of Chemical Sciences, University of Padova, Institute of Biomolecular Chemistry, CNR, via Marzolo 1, 35131 Padova, Italy. caporaleandrea74@gmail.com
Sturlese
Mattia
M
Gesiot
Lorenzo
L
Zanta
Fabrizio
F
Wittelsberger
Angela
A
Cabrele
Chiara
C
D002460:Cell Line; D002942:Circular Dichroism; D006801:Humans; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D010281:Parathyroid Hormone / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017433:Protein Structure, Secondary; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000819:agonists*; D013329:Structure-Activity Relationship
D007769:Lactams; D007783:Lactones; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D010456:Peptides, Cyclic; D044168:Receptor, Parathyroid Hormone, Type 1; C454802:parathyroid hormone (1-11)