Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation.
Peltier
Joseph
J
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720-3220, USA.
Conway
Anthony
A
Keung
Albert J
AJ
Schaffer
David V
DV
D000818:Animals; D015153:Blotting, Western / Q000379:methods; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D005455:Fluorescent Antibody Technique; D005822:Genetic Vectors; D057809:HEK293 Cells; D006624:Hippocampus / Q000166:cytology; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D010766:Phosphorylation; D055550:Protein Stability; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012263:Ribonucleosides / Q000494:pharmacology; D055748:SOXB1 Transcription Factors / Q000378:metabolism*
D012333:RNA, Messenger; D012263:Ribonucleosides; D055748:SOXB1 Transcription Factors; C527784:Sox2 protein, rat; C023764:triciribine; C494920:Akt1 protein, rat; D051057:Proto-Oncogene Proteins c-akt