Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery.
Yamazaki
Takanobu
T
Development Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi, 329-0114, Japan. takanobu.yamazaki@mb.kyorin-pharm.co.jp
Anraku
Tsuyoshi
T
Matsuzawa
Shigeki
S
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000502:physiology; D006152:Cyclic GMP / Q000378:metabolism*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D058987:Phosphodiesterase 3 Inhibitors / Q000494:pharmacology*; D058988:Phosphodiesterase 4 Inhibitors / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D015398:Signal Transduction; D014665:Vasodilator Agents / Q000494:pharmacology*; D014711:Vertebral Artery / Q000187:drug effects* / Q000502:physiology; D007212:Indolizines; D011720:Pyrazoles
D000225:Adenine; D000067956:Adenylyl Cyclase Inhibitors; D006152:Cyclic GMP; D006162:Guanylate Cyclase; D009569:Nitric Oxide; D058987:Phosphodiesterase 3 Inhibitors; D058988:Phosphodiesterase 4 Inhibitors; D011725:Pyridines; D014665:Vasodilator Agents; C017759:9-(tetrahydro-2-furyl)-adenine; C038366:ibudilast; D007212:Indolizines; D011720:Pyrazoles