Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9.
Ren
Shuang
S
Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Guo
Ling-Li
LL
Yang
Jie
J
Liu
Dai-Shun
DS
Wang
Tao
T
Chen
Lei
L
Chen
Ya-Juan
YJ
Xu
Dan
D
Feng
Yu-Lin
YL
Wen
Fu-Qiang
FQ
D000171:Acrolein / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004318:Doxycycline / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics* / Q000378:metabolism*; D055271:Mucin 5AC / Q000235:genetics; D009077:Mucins / Q000096:biosynthesis*; D009093:Mucus / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; C524680:Muc5ac protein, rat; D055271:Mucin 5AC; D009077:Mucins; D000171:Acrolein; D020780:Matrix Metalloproteinase 9; D004318:Doxycycline