A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.
Yamamoto
Toshihiro
T
Pharmacology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan. Yamamoto_Toshihiro@takeda.co.jp
Yamaguchi
Hiroshi
H
Miki
Hiroshi
H
Kitamura
Shuji
S
Nakada
Yoshihisa
Y
Aicher
Thomas D
TD
Pratt
Scott A
SA
Kato
Koki
K
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000502:physiology; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology*; D013045:Species Specificity; D014280:Triglycerides / Q000378:metabolism
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004791:Enzyme Inhibitors; C557887:N-(2-(((1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)carbonyl)amino)ethyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide; D011720:Pyrazoles; D014280:Triglycerides; D009536:Niacinamide; C494882:Dgat1 protein, mouse; D051048:Diacylglycerol O-Acyltransferase