The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells.
Kaufman
R J
RJ
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI, USA. kaufmanr@umich.edu
Back
S H
SH
Song
B
B
Han
J
J
Hassler
J
J
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology*; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology; D051742:Transcription Factor CHOP / Q000235:genetics / Q000378:metabolism; D056811:Unfolded Protein Response / Q000502:physiology*; D019892:eIF-2 Kinase / Q000096:biosynthesis
D051742:Transcription Factor CHOP; D019892:eIF-2 Kinase