title: The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
authors.affiliation: Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Yu
authors.forename: Bing-Mei
authors.initials: BM
authors.lastname: Zhu
authors.forename: Mark
authors.initials: M
authors.lastname: Wickre
authors.forename: Gregory
authors.initials: G
authors.lastname: Riedlinger
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hosui
authors.forename: Gertraud W
authors.initials: GW
authors.lastname: Robinson
authors.forename: Lothar
authors.initials: L
authors.lastname: Hennighausen
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D002453:Cell Cycle; D002455:Cell Division; D050764:Cyclin-Dependent Kinase Inhibitor p19 / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006706:Homeostasis; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000235:genetics; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D020411:Oligonucleotide Array Sequence Analysis; D050799:STAT5 Transcription Factor / Q000172:deficiency / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C493957:Cdkn1a protein, mouse; C493975:Cdkn2d protein, mouse; D050764:Cyclin-Dependent Kinase Inhibitor p19; D050759:Cyclin-Dependent Kinase Inhibitor p21; D050799:STAT5 Transcription Factor; C494093:Stat5a protein, mouse; C494096:Stat5b protein, mouse; D025521:Tumor Suppressor Proteins; D002251:Carbon Tetrachloride