title: Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
authors.affiliation: Division of Infectious Diseases, Imperial College London, London W2 1PG, United Kingdom.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hare
authors.forename: Ann M
authors.initials: AM
authors.lastname: Vos
authors.forename: Reginald F
authors.initials: RF
authors.lastname: Clayton
authors.forename: Jan W
authors.initials: JW
authors.lastname: Thuring
authors.forename: Maxwell D
authors.initials: MD
authors.lastname: Cummings
authors.forename: Peter
authors.initials: P
authors.lastname: Cherepanov
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D020134:Catalytic Domain; D024882:Drug Resistance, Viral / Q000235:genetics*; D019143:Evolution, Molecular; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics; D020128:Inhibitory Concentration 50; D019426:Integrases / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology; D000068898:Raltegravir Potassium; D012190:Retroviridae / Q000201:enzymology*
chemical_list: D019428:HIV Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D019426:Integrases