hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation.
Mercier
Richard W
RW
School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Pei
Ying
Y
Pandarinathan
Lakshmipathi
L
Janero
David R
DR
Zhang
Jing
J
Makriyannis
Alexandros
A
D019943:Amino Acid Substitution; D003511:Cyclohexanols / Q000737:chemistry / Q000494:pharmacology; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology; D043885:Receptor, Cannabinoid, CB2 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D014316:Tritium / Q000737:chemistry
D003511:Cyclohexanols; D008024:Ligands; D011720:Pyrazoles; D043885:Receptor, Cannabinoid, CB2; D014316:Tritium; C054649:3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; D003545:Cysteine