title: Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.
authors.affiliation: Merck Research Laboratories, MSD, Newhouse, Lanarkshire, United Kingdom. jiaqiang.cai@merck.com
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Cai
authors.forename: John
authors.initials: J
authors.lastname: Robinson
authors.forename: Simone
authors.initials: S
authors.lastname: Belshaw
authors.forename: Kathryn
authors.initials: K
authors.lastname: Everett
authors.forename: Xavier
authors.initials: X
authors.lastname: Fradera
authors.forename: Mario
authors.initials: M
authors.lastname: van Zeeland
authors.forename: Leon
authors.initials: L
authors.lastname: van Berkom
authors.forename: Peter
authors.initials: P
authors.lastname: van Rijnsbergen
authors.forename: Lucy
authors.initials: L
authors.lastname: Popplestone
authors.forename: Mark
authors.initials: M
authors.lastname: Baugh
authors.forename: Maureen
authors.initials: M
authors.lastname: Dempster
authors.forename: John
authors.initials: J
authors.lastname: Bruin
authors.forename: William
authors.initials: W
authors.lastname: Hamilton
authors.forename: Emma
authors.initials: E
authors.lastname: Kinghorn
authors.forename: Paul
authors.initials: P
authors.lastname: Westwood
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kerr
authors.forename: Zoran
authors.initials: Z
authors.lastname: Rankovic
authors.forename: Wullie
authors.initials: W
authors.lastname: Arbuckle
authors.forename: D Jonathan
authors.initials: DJ
authors.lastname: Bennett
authors.forename: Philip S
authors.initials: PS
authors.lastname: Jones
authors.forename: Clive
authors.initials: C
authors.lastname: Long
authors.forename: Iain
authors.initials: I
authors.lastname: Martin
authors.forename: Joost C M
authors.initials: JC
authors.lastname: Uitdehaag
authors.forename: Tommi
authors.initials: T
authors.lastname: Meulemans
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005461:Fluorine; D006801:Humans; D007659:Ketones; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000814:Aniline Compounds; D015853:Cysteine Proteinase Inhibitors; D007659:Ketones; D005461:Fluorine; D002403:Cathepsins; C028217:cathepsin S