Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases.
Varney
Michelle L
ML
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA.
Singh
Seema
S
Li
Aihua
A
Mayer-Ezell
Rosemary
R
Bond
Richard
R
Singh
Rakesh K
RK
D000230:Adenocarcinoma / Q000556:secondary*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001549:Benzamides / Q000494:pharmacology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D003503:Cyclobutanes / Q000494:pharmacology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D009389:Neovascularization, Pathologic; D023062:Receptors, Interleukin-8A / Q000037:antagonists & inhibitors*; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors*; D023041:Xenograft Model Antitumor Assays
C516686:2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide; D000970:Antineoplastic Agents; D001549:Benzamides; D003503:Cyclobutanes; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; C544392:SCH 479833