title: Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.
authors.affiliation: Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Mien V
authors.initials: MV
authors.lastname: Hoang
authors.forename: Janice A
authors.initials: JA
authors.lastname: Nagy
authors.forename: Donald R
authors.initials: DR
authors.lastname: Senger
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D042683:Angiopoietin-1 / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D020405:Dermis / Q000166:cytology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D052816:Foreskin / Q000166:cytology / Q000378:metabolism; D005799:Genes, Dominant; D006801:Humans; D015151:Immunoblotting; D008297:Male; D051379:Mice; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D042683:Angiopoietin-1; D042442:Vascular Endothelial Growth Factors; D020830:rac1 GTP-Binding Protein