Evaluation and discrimination of simvastatin-induced structural alterations in proteins of different rat tissues by FTIR spectroscopy and neural network analysis.
Garip
Sebnem
S
Department of Biochemistry, Middle East Technical University, Ankara, 06531, Turkey.
Yapici
Engin
E
Ozek
Nihal Simsek
NS
Severcan
Mete
M
Severcan
Feride
F
D000818:Animals; D016000:Cluster Analysis; D005269:Femur / Q000187:drug effects; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D016571:Neural Networks, Computer; D017433:Protein Structure, Secondary / Q000187:drug effects; D011506:Proteins / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects; D019821:Simvastatin / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013737:Testis / Q000187:drug effects; D013977:Tibia / Q000187:drug effects
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011506:Proteins; D019821:Simvastatin