Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells.
Luo
Di-xian
DX
Department of Pharmacology, School of Pharmaceutics, Central South University, Changsha 410083, Hunan, China. luodixian_2@163.com
Xia
Cheng-lai
CL
Li
Jun-mu
JM
Xiong
Yan
Y
Yuan
Hao-yu
HY
Tang
Zhen-Wang
ZW
Zeng
Yixin
Y
Liao
Duan-fang
DF
D000818:Animals; D051242:Caveolin 1 / Q000378:metabolism*; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism*; D015536:Down-Regulation; D008077:Lipoproteins, LDL / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D011312:Pressure; D051381:Rats; D051780:Sterol Regulatory Element Binding Protein 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*
D051242:Caveolin 1; D008077:Lipoproteins, LDL; D051780:Sterol Regulatory Element Binding Protein 1; C099252:oxidized low density lipoprotein; D002784:Cholesterol