Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
Symons
Kent T
KT
Department of Biology, Kalypsys Inc, San Diego, California, USA.
Nguyen
Phan M
PM
Massari
Mark E
ME
Anzola
John V
JV
Staszewski
Lena M
LM
Wang
Li
L
Yazdani
Nahid
N
Dorow
Steven
S
Muhammad
Jerry
J
Sablad
Marciano
M
Rozenkrants
Natasha
N
Bonefous
Celine
C
Payne
Joseph E
JE
Rix
Peter J
PJ
Shiau
Andrew K
AK
Noble
Stewart A
SA
Smith
Nicholas D
ND
Hassig
Christian A
CA
Zhang
Yan
Y
Rao
Tadimeti S
TS
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D024841:Fluoroquinolones / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D055503:Protein Multimerization; D011719:Pyrazines / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity
C554421:4-((2-cyclobutyl-1H-imidazo(4,5-b)pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D011719:Pyrazines; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II