Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen.
Yi
Lan
L
Cancer Research Institute, University of South China, Hengyang City, Hunan Province, China.
Ji
Xiao-Xia
XX
Lin
Min
M
Tan
Hui
H
Tang
Yi
Y
Wen
Ling
L
Ma
Yan-Hua
YH
Su
Qi
Q
D000498:Allyl Compounds / Q000494:pharmacology*; D000873:Anthracenes / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D053938:DNA Fragmentation / Q000187:drug effects; D004220:Disulfides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000498:Allyl Compounds; D000873:Anthracenes; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004220:Disulfides; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D047428:Protein Kinase Inhibitors; D017382:Reactive Oxygen Species; C432165:pyrazolanthrone; C028009:diallyl disulfide; D048031:JNK Mitogen-Activated Protein Kinases