Simvastatin administration reduces thromboxane production in subjects taking aspirin: links between aspirin resistance and thrombin generation.
Undas
Anetta
A
The Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland. mmundas@cyf-kr.edu.pl
Siudak
Zbigniew
Z
Topór-Mądry
Roman
R
Leśniak
Marta
M
Tracz
Wiesława
W
D001241:Aspirin / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004351:Drug Resistance; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D019821:Simvastatin / Q000494:pharmacology*; D013917:Thrombin / Q000096:biosynthesis*; D013928:Thromboxane A2 / Q000096:biosynthesis*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D013928:Thromboxane A2; D019821:Simvastatin; D013917:Thrombin; D001241:Aspirin