The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes.
Karlmark
Karlin Raja
KR
Department of Medicine III, University Hospital Aachen, Aachen, Germany.
Zimmermann
Henning W
HW
Roderburg
Christoph
C
Gassler
Nikolaus
N
Wasmuth
Hermann E
HE
Luedde
Tom
T
Trautwein
Christian
C
Tacke
Frank
F
D000199:Actins / Q000235:genetics; D000410:Alanine Transaminase / Q000235:genetics; D000818:Animals; D016026:Bone Marrow Transplantation; D000073883:CX3C Chemokine Receptor 1; D002454:Cell Differentiation / Q000187:drug effects*; D003433:Crosses, Genetic; D005434:Flow Cytometry; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000502:physiology; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008103:Liver Cirrhosis / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects; D016133:Polymerase Chain Reaction; D019707:Receptors, Chemokine / Q000172:deficiency / Q000627:therapeutic use*
D000199:Actins; D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; C471885:Cx3cr1 protein, mouse; D019707:Receptors, Chemokine; C544013:alpha-smooth muscle actin, mouse; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D000410:Alanine Transaminase