Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies.
Timmerman
Peter
P
Pepscan Therapeutics B.V., Zuidersluisweg 2, 8243 RC Lelystad, The Netherlands. daniele.Altschuh@unistra.fr
Shochat
Susana G
SG
Desmet
Johan
J
Barderas
Rodrigo
R
Casal
Jose Ignacio
JI
Meloen
Rob H
RH
Altschuh
Danièle
D
D000595:Amino Acid Sequence; D000906:Antibodies / Q000737:chemistry / Q000378:metabolism*; D000915:Antibody Affinity / Q000502:physiology*; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001666:Binding Sites, Antibody / Q000502:physiology; D022801:Complementarity Determining Regions / Q000737:chemistry* / Q000378:metabolism*; D003198:Computer Simulation; D018604:Epitope Mapping; D005755:Gastrins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009113:Muramidase / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D040081:Protein Array Analysis; D011485:Protein Binding
D000906:Antibodies; D000936:Antigen-Antibody Complex; D022801:Complementarity Determining Regions; D005755:Gastrins; D007328:Insulin; D010446:Peptide Fragments; D009113:Muramidase