Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner--a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2.
Koch
Felix Peter
FP
Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University Mainz, Augustusplatz 2, Mainz, Germany. koch@mkg.klinik.uni-mainz.de
Merkel
Christina
C
Al-Nawas
Bilal
B
Smeets
Ralf
R
Ziebart
Thomas
T
Walter
Christian
C
Wagner
Wilfried
W
D015415:Biomarkers / Q000032:analysis; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000187:drug effects; D004002:Clodronic Acid / Q000494:pharmacology; D050659:Core Binding Factor Alpha 1 Subunit / Q000032:analysis*; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects; D018398:Homeodomain Proteins / Q000032:analysis*; D006801:Humans; D000077557:Ibandronic Acid; D007093:Imidazoles / Q000494:pharmacology; D051957:MSX1 Transcription Factor / Q000032:analysis*; D010006:Osteoblasts / Q000187:drug effects*; D015675:Osteocalcin / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014157:Transcription Factors / Q000032:analysis*; D000077211:Zoledronic Acid
D015415:Biomarkers; D050071:Bone Density Conservation Agents; D050659:Core Binding Factor Alpha 1 Subunit; C100596:DLX5 protein, human; D004164:Diphosphonates; D018398:Homeodomain Proteins; D007093:Imidazoles; D051957:MSX1 Transcription Factor; C484083:MSX1 protein, human; C084119:MSX2 protein; C493709:RUNX2 protein, human; D014157:Transcription Factors; D004002:Clodronic Acid; D015675:Osteocalcin; D000077211:Zoledronic Acid; D000077557:Ibandronic Acid