title: The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
authors.affiliation: Institute of Pharmaceutical Biology/ZAFES, Goethe-University of Frankfurt, Biocenter, Frankfurt/Main, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Benedikt
authors.forename: S
authors.initials: S
authors.lastname: Baltruschat
authors.forename: B
authors.initials: B
authors.lastname: Scholz
authors.forename: A
authors.initials: A
authors.lastname: Bursen
authors.forename: T N
authors.initials: TN
authors.lastname: Arrey
authors.forename: B
authors.initials: B
authors.lastname: Meyer
authors.forename: L
authors.initials: L
authors.lastname: Varagnolo
authors.forename: A M
authors.initials: AM
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Karas
authors.forename: T
authors.initials: T
authors.lastname: Dingermann
authors.forename: R
authors.initials: R
authors.lastname: Marschalek
mesh_terms: D002850:Chromatography, Gel; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000502:physiology*; D004789:Enzyme Activation; D044127:Epigenesis, Genetic; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000209:etiology*; D008745:Methylation; D051788:Myeloid-Lymphoid Leukemia Protein / Q000302:isolation & purification / Q000502:physiology*; D009687:Nuclear Proteins / Q000302:isolation & purification / Q000502:physiology*; D015514:Oncogene Proteins, Fusion / Q000302:isolation & purification / Q000502:physiology*; D010766:Phosphorylation; D042925:Positive Transcriptional Elongation Factor B / Q000378:metabolism*; D035602:Transcriptional Elongation Factors
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones; C497422:KMT2A protein, human; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D035602:Transcriptional Elongation Factors; D051788:Myeloid-Lymphoid Leukemia Protein; C081449:AFF1 protein, human; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D042925:Positive Transcriptional Elongation Factor B