Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity.
Stewart
Joanna D
JD
Mitochondrial Research Group, Institute of Human Genetics, Newcastle University, UK.
Horvath
Rita
R
Baruffini
Enrico
E
Ferrero
Iliana
I
Bulst
Stefanie
S
Watkins
Paul B
PB
Fontana
Robert J
RJ
Day
Christopher P
CP
Chinnery
Patrick F
PF
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D001714:Bipolar Disorder / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000235:genetics; D018682:GABA Agents / Q000009:adverse effects / Q000627:therapeutic use; D014644:Genetic Variation; D006261:Headache / Q000188:drug therapy; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012640:Seizures / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
D018682:GABA Agents; D014635:Valproic Acid; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase; C413027:POLG protein, human