Na(+)-H(+) exchange blockade, using amiloride, decreases the inflammatory response following hemorrhagic shock and resuscitation in rats.
Soliman
Mona M
MM
Department of Physiology, College of Medicine, King Saud University, P.O. Box 29825 (29), Riyadh 11461, Saudi Arabia. monaslmn@yahoo.com
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors*
D002316:Cardiotonic Agents; D018836:Inflammation Mediators; D017923:Sodium-Hydrogen Exchangers; D000584:Amiloride