Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.
Beloueche-Babari
Mounia
M
Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom. Mounia.Beloueche-Babari@icr.ac.uk
Arunan
Vaitha
V
Jackson
L Elizabeth
LE
Perusinghe
Nina
N
Sharp
Swee Y
SY
Workman
Paul
P
Leach
Martin O
MO
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016227:Benzoquinones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D054316:Biomarkers, Pharmacological; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D047029:Lactams, Macrocyclic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D009154:Mutation / Q000235:genetics; D009281:Naphthalenes / Q000494:pharmacology; D064801:Phospholipase A2 Inhibitors; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics / Q000378:metabolism; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
D000970:Antineoplastic Agents; D016227:Benzoquinones; D054316:Biomarkers, Pharmacological; C506244:CCT018159; D018841:HSP90 Heat-Shock Proteins; D006574:Heterocyclic Compounds, 2-Ring; D047029:Lactams, Macrocyclic; D009281:Naphthalenes; D064801:Phospholipase A2 Inhibitors; D011720:Pyrazoles; D011753:Pyrones; C112765:tanespimycin; D005997:Glycerylphosphorylcholine; C068314:6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
Hsp90; MRS; melanoma; metabolism; phospholipid