Sinonasal inhalation of dornase alfa in CF: A double-blind placebo-controlled cross-over pilot trial.
Mainz
Jochen G
JG
Department of Paediatrics, Cystic Fibrosis Centre, University Hospital of Jena, Kochstrasse 2, 07740 Jena, Germany. Jochen.Mainz@med.uni-jena.de
Schiller
Isabella
I
Ritschel
Christiane
C
Mentzel
Hans-Joachim
HJ
Riethmüller
Joachim
J
Koitschev
Assen
A
Schneider
Gerlind
G
Beck
James F
JF
Wiedemann
Baerbel
B
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D002648:Child; D018592:Cross-Over Studies; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003850:Deoxyribonuclease I / Q000008:administration & dosage*; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology; D009298:Nasal Polyps / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D009330:Nebulizers and Vaporizers; D010865:Pilot Projects; D011788:Quality of Life / Q000523:psychology; D011994:Recombinant Proteins / Q000627:therapeutic use; D012220:Rhinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D055815:Young Adult
D011994:Recombinant Proteins; C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I