title: Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.
authors.affiliation: UMR5201, CNRS, Université de Lyon, Centre Léon Bérard, 28 Rue Laennec, Lyon 69373, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Mouchiroud
authors.forename: Laurent
authors.initials: L
authors.lastname: Molin
authors.forename: Prasad
authors.initials: P
authors.lastname: Kasturi
authors.forename: Mohamed N
authors.initials: MN
authors.lastname: Triba
authors.forename: Marc Emmanuel
authors.initials: ME
authors.lastname: Dumas
authors.forename: Marieangela C
authors.initials: MC
authors.lastname: Wilson
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Halestrap
authors.forename: Damien
authors.initials: D
authors.lastname: Roussel
authors.forename: Ingrid
authors.initials: I
authors.lastname: Masse
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dallière
authors.forename: Laurent
authors.initials: L
authors.lastname: Ségalat
authors.forename: Marc
authors.initials: M
authors.lastname: Billaud
authors.forename: Florence
authors.initials: F
authors.lastname: Solari
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D031204:Caloric Restriction; D004843:Epistasis, Genetic / Q000502:physiology; D057166:High-Throughput Screening Assays; D008136:Longevity / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D008660:Metabolism / Q000235:genetics; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D027501:Monocarboxylic Acid Transporters / Q000235:genetics* / Q000378:metabolism; D009154:Mutation / Q000502:physiology*; D018384:Oxidative Stress; D051059:PTEN Phosphohydrolase / Q000502:physiology; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D019289:Pyruvic Acid / Q000378:metabolism; D034622:RNA Interference; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; C116661:DAF-18 protein, C elegans; D026901:Membrane Transport Proteins; D027501:Monocarboxylic Acid Transporters; D011768:Pyruvate Dehydrogenase Complex; C559223:SLCF-1 protein, C elegans; D014157:Transcription Factors; D019289:Pyruvic Acid; D051059:PTEN Phosphohydrolase