Correlation of pharmacokinetic features and tissue distribution with toxicity of Q39, a hypoxic cell cytotoxic agent.
Zhu
Difeng
D
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China.
Lou
Jianshu
J
Wu
Honghai
H
Luo
Peihua
P
Li
Lanjuan
L
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000633:toxicity*; D019540:Area Under Curve; D015687:Cell Hypoxia / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D020014:K562 Cells / Q000637:transplantation; D007928:Lethal Dose 50; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011810:Quinoxalines / Q000493:pharmacokinetics* / Q000633:toxicity*; D012015:Reference Standards; D014018:Tissue Distribution
C528740:3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide; D000970:Antineoplastic Agents; D011810:Quinoxalines