TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
Zeng
Zhihong
Z
Genome Damage and Stability Centre, Science Park Road, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom.
Cortés-Ledesma
Felipe
F
El Khamisy
Sherif F
SF
Caldecott
Keith W
KW
D000818:Animals; D045744:Cell Line, Tumor; D004249:DNA Damage; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000172:deficiency / Q000378:metabolism*; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000172:deficiency / Q000378:metabolism*
D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D005047:Etoposide; D010727:Phosphoric Diester Hydrolases; C122147:tyrosyl-DNA phosphodiesterase; D004250:DNA Topoisomerases, Type II