TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.
Minang
Jacob T
JT
AIDS and Cancer Virus Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA.
Trivett
Matthew T
MT
Barsov
Eugene V
EV
Del Prete
Gregory Q
GQ
Trubey
Charles M
CM
Thomas
James A
JA
Gorelick
Robert J
RJ
Piatak
Michael
M
Ott
David E
DE
Ohlen
Claes
C
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000378:metabolism; D065100:CCR5 Receptor Antagonists; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D015536:Down-Regulation; D005260:Female; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*
D000911:Antibodies, Monoclonal; D065100:CCR5 Receptor Antagonists; D017252:CD3 Complex; D004279:DNA, Viral; C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D011948:Receptors, Antigen, T-Cell; D019713:Receptors, CCR5