Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats.
Raffai
Gábor
G
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Wang
Jingli
J
Roman
Richard J
RJ
Anjaiah
Siddam
S
Weinberg
Brian
B
Falck
John R
JR
Lombard
Julian H
JH
D000577:Amides / Q000494:pharmacology; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D042926:Cytochrome P-450 CYP4A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019332:Endothelin-1 / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006893:Hydroxyeicosatetraenoic Acids / Q000819:agonists / Q000096:biosynthesis / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000503:physiopathology*; D018715:Microscopy, Video; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D020303:Rats, Inbred Dahl; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage* / Q000633:toxicity; D013450:Sulfones / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
C494665:20-hydroxyeicosa-5(Z),14(Z)-dienoic acid; D000577:Amides; D016861:Cyclooxygenase Inhibitors; D019332:Endothelin-1; D004791:Enzyme Inhibitors; D006893:Hydroxyeicosatetraenoic Acids; D017673:Sodium Chloride, Dietary; D013450:Sulfones; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid; C117975:DDMS; D019001:Nitric Oxide Synthase; D042926:Cytochrome P-450 CYP4A; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine; D007213:Indomethacin