title: CDDO-Im is a stimulator of megakaryocytic differentiation.
authors.affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Suepriore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Petronelli
authors.forename: Elvira
authors.initials: E
authors.lastname: Pelosi
authors.forename: Simona
authors.initials: S
authors.lastname: Santoro
authors.forename: Ernestina
authors.initials: E
authors.lastname: Saulle
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cerio
authors.forename: Gualtiero
authors.initials: G
authors.lastname: Mariani
authors.forename: Catherine
authors.initials: C
authors.lastname: Labbaye
authors.forename: Ugo
authors.initials: U
authors.lastname: Testa
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D041905:Erythroid Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005434:Flow Cytometry; D050982:GATA1 Transcription Factor / Q000378:metabolism; D050989:GATA2 Transcription Factor / Q000378:metabolism; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D039661:Integrin beta3 / Q000378:metabolism; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology; D008533:Megakaryocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D040201:Platelet Membrane Glycoprotein IIb / Q000378:metabolism; D013997:Time Factors
chemical_list: C472829:1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole; D018952:Antigens, CD34; D050982:GATA1 Transcription Factor; D050989:GATA2 Transcription Factor; C494711:GATA2 protein, human; D007093:Imidazoles; D039661:Integrin beta3; D040201:Platelet Membrane Glycoprotein IIb; D009828:Oleanolic Acid; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3