Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells.
Kwack
Mi Hee
MH
Department of Immunology, School of Medicine, Kyungpook National University, Daegu 700-422, Korea. ysung@knu.ac.kr
Ahn
Ji Sup
JS
Kim
Moon Kyu
MK
Kim
Jung Chul
JC
Sung
Young Kwan
YK
D000505:Alopecia / Q000139:chemically induced / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D000728:Androgens / Q000009:adverse effects; D001205:Ascorbic Acid / Q000378:metabolism; D002087:Butyrates / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D018890:Chemoprevention / Q000379:methods; D018920:Coculture Techniques; D020405:Dermis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013196:Dihydrotestosterone / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005786:Gene Expression Regulation / Q000187:drug effects; D018859:Hair Follicle / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D008297:Male
D000728:Androgens; D002087:Butyrates; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D013196:Dihydrotestosterone; C011369:threonic acid; D001205:Ascorbic Acid