Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.
Mouchiroud
Laurent
L
UMR5201, CNRS, Université de Lyon, Centre Léon Bérard, 28 Rue Laennec, Lyon 69373, France.
Molin
Laurent
L
Kasturi
Prasad
P
Triba
Mohamed N
MN
Dumas
Marc Emmanuel
ME
Wilson
Marieangela C
MC
Halestrap
Andrew P
AP
Roussel
Damien
D
Masse
Ingrid
I
Dallière
Nicolas
N
Ségalat
Laurent
L
Billaud
Marc
M
Solari
Florence
F
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D031204:Caloric Restriction; D004843:Epistasis, Genetic / Q000502:physiology; D057166:High-Throughput Screening Assays; D008136:Longevity / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D008660:Metabolism / Q000235:genetics; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D027501:Monocarboxylic Acid Transporters / Q000235:genetics* / Q000378:metabolism; D009154:Mutation / Q000502:physiology*; D018384:Oxidative Stress; D051059:PTEN Phosphohydrolase / Q000502:physiology; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D019289:Pyruvic Acid / Q000378:metabolism; D034622:RNA Interference; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; C116661:DAF-18 protein, C elegans; D026901:Membrane Transport Proteins; D027501:Monocarboxylic Acid Transporters; D011768:Pyruvate Dehydrogenase Complex; C559223:SLCF-1 protein, C elegans; D014157:Transcription Factors; D019289:Pyruvic Acid; D051059:PTEN Phosphohydrolase