Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes.
Sun
Huichao
H
Heart Centre, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Yang
Xuefang
X
Zhu
Jing
J
Lv
Tiewei
T
Chen
Yuan
Y
Chen
Guozhen
G
Zhong
Lilin
L
Li
Yasha
Y
Huang
Xupei
X
Huang
Guoying
G
Tian
Jie
J
D000107:Acetylation / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D047369:Chromatin Immunoprecipitation; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D044127:Epigenesis, Genetic; D006657:Histones / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D011401:Promoter Regions, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050880:p300-CBP Transcription Factors / Q000037:antagonists & inhibitors*; D000099224:p300-CBP-Associated Factor
D003474:Curcumin; D004791:Enzyme Inhibitors; D006657:Histones; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor