Low dose of bupropion significantly enhances the anticonvulsant activity of felbamate, lamotrigine and topiramate in mice.
Barczyński
Bartłomiej
B
Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Lublin, Poland.
Buszewicz
Grzegorz
G
Łuszczki
Jarogniew J
JJ
Bańka
Krzysztof
K
Tutaj
Krzysztof
K
Mróz
Tomasz
T
Wielosz
Marian
M
Mądro
Roman
R
Tutka
Piotr
P
D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016642:Bupropion / Q000008:administration & dosage* / Q000627:therapeutic use; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004597:Electroshock; D000078328:Felbamate; D005632:Fructose / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D000077213:Lamotrigine; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D048448:Phenylcarbamates / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D011409:Propylene Glycols / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D011597:Psychomotor Performance / Q000187:drug effects; D045442:Rotarod Performance Test; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D000077236:Topiramate; D014227:Triazines / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
D000927:Anticonvulsants; D018765:Dopamine Uptake Inhibitors; D048448:Phenylcarbamates; D011409:Propylene Glycols; D014227:Triazines; D016642:Bupropion; D000077236:Topiramate; D005632:Fructose; D000077213:Lamotrigine; D000078328:Felbamate