Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
Grudzien
Peter
P
Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA.
Lo
Shelly
S
Albain
Kathy S
KS
Robinson
Patricia
P
Rajan
Prabha
P
Strack
Peter R
PR
Golde
Todd E
TE
Miele
Lucio
L
Foreman
Kimberly E
KE
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D003499:Cyclic S-Oxides / Q000494:pharmacology; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D051880:Receptors, Notch / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D018874:Spheroids, Cellular; D013830:Thiadiazoles / Q000494:pharmacology
D053829:Amyloid Precursor Protein Secretases; D003499:Cyclic S-Oxides; D018719:Erb-b2 Receptor Tyrosine Kinases; D051880:Receptors, Notch; D013830:Thiadiazoles; C523799:MRK 003