4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
Cho
Young Shin
YS
Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. youngshin.cho@novartis
Borland
Maria
M
Brain
Christopher
C
Chen
Christine H-T
CH
Cheng
Hong
H
Chopra
Rajiv
R
Chung
Kristy
K
Groarke
James
J
He
Guo
G
Hou
Ying
Y
Kim
Sunkyu
S
Kovats
Steven
S
Lu
Yipin
Y
O'Reilly
Marc
M
Shen
Junqing
J
Smith
Troy
T
Trakshel
Gary
G
Vögtle
Markus
M
Xu
Mei
M
Xu
Ming
M
Sung
Moo Je
MJ
D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D051358:Cyclin-Dependent Kinase 4 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D051361:Cyclin-Dependent Kinase 6 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D057166:High-Throughput Screening Assays; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011720:Pyrazoles; D011743:Pyrimidines; D051358:Cyclin-Dependent Kinase 4; D051361:Cyclin-Dependent Kinase 6