title: Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
authors.affiliation: Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, 80523-1618, USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Dregalla
authors.forename: Junqing
authors.initials: J
authors.lastname: Zhou
authors.forename: Rupa R
authors.initials: RR
authors.lastname: Idate
authors.forename: Christine L R
authors.initials: CL
authors.lastname: Battaglia
authors.forename: Howard L
authors.initials: HL
authors.lastname: Liber
authors.forename: Susan M
authors.initials: SM
authors.lastname: Bailey
mesh_terms: D000244:Adenosine Diphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D034961:Antigens, Nuclear / Q000235:genetics / Q000378:metabolism; D001549:Benzamides / Q000494:pharmacology; D055162:Biocatalysis / Q000187:drug effects; D016923:Cell Death / Q000528:radiation effects; D002461:Cell Line, Transformed; D045744:Cell Line, Tumor; D002867:Chromones / Q000494:pharmacology; D043171:Chromosomal Instability / Q000235:genetics; D002869:Chromosome Aberrations / Q000528:radiation effects; D004260:DNA Repair / Q000502:physiology*; D051747:DNA-Activated Protein Kinase / Q000032:analysis / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D015870:Gene Expression / Q000235:genetics; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology; D006801:Humans; D000072200:Ku Autoantigen; D008954:Models, Biological; D009025:Morpholines / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D009687:Nuclear Proteins / Q000032:analysis / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D011759:Pyrrolidines / Q000494:pharmacology; D034741:RNA, Small Interfering / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000502:physiology*; D038501:Tankyrases / Q000037:antagonists & inhibitors / Q000502:physiology*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
chemical_list: D000244:Adenosine Diphosphate; D034961:Antigens, Nuclear; D001549:Benzamides; D002867:Chromones; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D006026:Glycoside Hydrolases; D006575:Heterocyclic Compounds, 3-Ring; D000072200:Ku Autoantigen; D009025:Morpholines; D009687:Nuclear Proteins; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases; D046988:Proteasome Endopeptidase Complex; D061988:Proteasome Inhibitors; D011759:Pyrrolidines; D034741:RNA, Small Interfering; D038501:Tankyrases; C479235:2-(morpholin-4-yl)benzo(h)chromen-4-one; C544261:XAV939; C096272:adenosine diphosphate (hydroxymethyl)pyrrolidinediol; C025160:3-aminobenzamide; C418109:TNKS protein, human; C497263:PRKDC protein, human; C022407:poly ADP-ribose glycohydrolase; C000606509:Xrcc6 protein, human