title: An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.
authors.affiliation: Institut de Recherches Cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, PQ H2W 1R7, Canada.
authors.forename: Manishha
authors.initials: M
authors.lastname: Patel
authors.forename: Yoran
authors.initials: Y
authors.lastname: Margaron
authors.forename: Nadine
authors.initials: N
authors.lastname: Fradet
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.forename: Brian
authors.initials: B
authors.lastname: Wilkes
authors.forename: Michel
authors.initials: M
authors.lastname: Bouvier
authors.forename: Kay
authors.initials: K
authors.lastname: Hofmann
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Côté
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D015374:Biosensing Techniques; D019295:Computational Biology; D017124:Conserved Sequence; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D020798:Two-Hybrid System Techniques; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C521975:Ced-12 protein, Drosophila; C099818:DOCK1 protein, human; D029721:Drosophila Proteins; C465214:ELMO1 protein, human; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein