An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.
Patel
Manishha
M
Institut de Recherches Cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, PQ H2W 1R7, Canada.
Margaron
Yoran
Y
Fradet
Nadine
N
Yang
Qi
Q
Wilkes
Brian
B
Bouvier
Michel
M
Hofmann
Kay
K
Côté
Jean-François
JF
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D015374:Biosensing Techniques; D019295:Computational Biology; D017124:Conserved Sequence; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D020798:Two-Hybrid System Techniques; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; C521975:Ced-12 protein, Drosophila; C099818:DOCK1 protein, human; D029721:Drosophila Proteins; C465214:ELMO1 protein, human; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein