Nonlinear pharmacokinetics of piperacillin in healthy volunteers--implications for optimal dosage regimens.
Bulitta
Jürgen B
JB
IBMP -Institute for Biomedical and Pharmaceutical Research, Paul-Ehrlich-Str. 19, D-90562 Nürnberg-Heroldsberg, Germany.
Kinzig
Martina
M
Jakob
Verena
V
Holzgrabe
Ulrike
U
Sörgel
Fritz
F
Holford
Nicholas H G
NH
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D015233:Models, Statistical; D009010:Monte Carlo Method; D010878:Piperacillin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D055815:Young Adult
D000900:Anti-Bacterial Agents; D010878:Piperacillin