5-fluorouracil-induced death of Jurkat T-cells--a role for caspases and MCL-1.
Aresvik
Dina M
DM
Department of Paediatric Research, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway. Dina.Aresvik@rr-research.no
Pettersen
Rolf D
RD
Abrahamsen
Tore G
TG
Wright
Marianne S
MS
D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism*; D061945:Caspase Inhibitors; D016923:Cell Death / Q000187:drug effects* / Q000502:physiology; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D019169:Jurkat Cells; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D000590:Amino Acid Chloromethyl Ketones; D000964:Antimetabolites, Antineoplastic; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; D011065:Poly(ADP-ribose) Polymerases; D053148:Caspase 3; D005472:Fluorouracil