Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction.
Ceylan-Isik
Asli F
AF
Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.
Sreejayan
Nair
N
Ren
Jun
J
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015153:Blotting, Western; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004452:Echocardiography; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005951:Glucose Tolerance Test; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009200:Myocardial Contraction / Q000187:drug effects*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology*
D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium