Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.
Rebres
Robert A
RA
Alliance for Cellular Signaling, Northern California Institute for Research and Education, University of California, Veterans Affairs Medical Center, San Francisco, California 94121, USA. rarebres@yahoo.com
Roach
Tamara I A
TI
Fraser
Iain D C
ID
Philip
Finly
F
Moon
Christina
C
Lin
Keng-Mean
KM
Liu
Jamie
J
Santat
Leah
L
Cheadle
Lucas
L
Ross
Elliott M
EM
Simon
Melvin I
MI
Seaman
William E
WE
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D015936:Complement C5a / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism*; D044387:GTP-Binding Protein beta Subunits / Q000378:metabolism*; D044388:GTP-Binding Protein gamma Subunits / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D016296:Mutagenesis; D041681:NIH 3T3 Cells; D054799:Phospholipase C beta / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D014530:Uridine Diphosphate / Q000378:metabolism
D044387:GTP-Binding Protein beta Subunits; D044388:GTP-Binding Protein gamma Subunits; D034741:RNA, Small Interfering; D018048:Receptors, Purinergic P2; D014530:Uridine Diphosphate; D015936:Complement C5a; C518039:PLCB3 protein, human; D054799:Phospholipase C beta; C518034:Plcb1 protein, mouse; C518037:Plcb2 protein, mouse; C518040:Plcb3 protein, mouse; C518043:Plcb4 protein, mouse; D043802:GTP-Binding Protein alpha Subunits, Gq-G11