Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa.
Hanessian
Stephen
S
Department of Chemistry, Université de Montréal, Montréal, QC, Canada. stephen.hanessian@umontreal.ca
Larsson
Andreas
A
Fex
Tomas
T
Knecht
Wolfgang
W
Blomberg
Niklas
N
D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D015195:Drug Design; D015945:Factor XIa / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000925:Anticoagulants; D007211:Indoles; D015842:Serine Proteinase Inhibitors; D015945:Factor XIa