Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.
McMurchy
Alicia N
AN
Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Gillies
Jana
J
Allan
Sarah E
SE
Passerini
Laura
L
Gambineri
Eleonora
E
Roncarolo
Maria Grazia
MG
Bacchetta
Rosa
R
Levings
Megan K
MK
D000293:Adolescent; D015704:CD4 Antigens / Q000096:biosynthesis; D049109:Cell Proliferation; D054338:Cell Transdifferentiation / Q000235:genetics; D002478:Cells, Cultured; D002648:Child; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D007165:Immunosuppression Therapy; D050505:Mutant Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D017354:Point Mutation / Q000235:genetics; D016884:Polyendocrinopathies, Autoimmune; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019076:Transgenes / Q000235:genetics; D055815:Young Adult
D015704:CD4 Antigens; D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D050505:Mutant Proteins