An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.
Dave
Khyati
K
Temple University School of Pharmacy, Department of Pharmaceutical Sciences, 3307 North Broad Street, Philadelphia, PA 19140, USA.
Ilies
Marc A
MA
Scozzafava
Andrea
A
Temperini
Claudia
C
Vullo
Daniela
D
Supuran
Claudiu T
CT
D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D002256:Carbonic Anhydrases; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D020536:Enzyme Activators / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D011726:Pyridinium Compounds / Q000737:chemistry*
D020536:Enzyme Activators; D007093:Imidazoles; D011726:Pyridinium Compounds; C029899:imidazole; D024402:Carbonic Anhydrase II; D002256:Carbonic Anhydrases