title: Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel.
authors.affiliation: Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-Ku, Tokyo, 140-8710, Japan. hagihara.katsunobu.fc@daiichisankyo.co.jp
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Hagihara
authors.forename: Miho
authors.initials: M
authors.lastname: Kazui
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kurihara
authors.forename: Kazuishi
authors.initials: K
authors.lastname: Kubota
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001711:Biotransformation; D015153:Blotting, Western; D002850:Chromatography, Gel; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D054477:Glutaredoxins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D010879:Piperazines / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D000068799:Prasugrel Hydrochloride; D053719:Tandem Mass Spectrometry; D013876:Thiophenes / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D013879:Thioredoxins / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D054477:Glutaredoxins; D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; C510685:R-138727; D013876:Thiophenes; D013879:Thioredoxins; D000068799:Prasugrel Hydrochloride; D005978:Glutathione