Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.
Hoang
Mien V
MV
Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA.
Nagy
Janice A
JA
Senger
Donald R
DR
D008841:Actin Cytoskeleton / Q000378:metabolism; D042683:Angiopoietin-1 / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D020405:Dermis / Q000166:cytology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D052816:Foreskin / Q000166:cytology / Q000378:metabolism; D005799:Genes, Dominant; D006801:Humans; D015151:Immunoblotting; D008297:Male; D051379:Mice; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
D042683:Angiopoietin-1; D042442:Vascular Endothelial Growth Factors; D020830:rac1 GTP-Binding Protein