GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.
Peeters
Miriam C
MC
Division of Medicinal Chemistry, Leiden/Amsterdam Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
van Westen
Gerard J P
GJ
Guo
Dong
D
Wisse
Lisanne E
LE
Müller
Christa E
CE
Beukers
Margot W
MW
Ijzerman
Adriaan P
AP
D058908:Adenosine A2 Receptor Agonists / Q000494:pharmacology; D058917:Adenosine A2 Receptor Antagonists / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide) / Q000737:chemistry / Q000494:pharmacology; D000595:Amino Acid Sequence; D000631:Aminopyridines / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D016297:Mutagenesis, Site-Directed; D011487:Protein Conformation; D043704:Receptor, Adenosine A2B / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014227:Triazines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D058908:Adenosine A2 Receptor Agonists; D058917:Adenosine A2 Receptor Antagonists; D000631:Aminopyridines; C518875:BAY 60-6583; D043704:Receptor, Adenosine A2B; D014227:Triazines; D014230:Triazoles; C097270:ZM 241385; D019830:Adenosine-5'-(N-ethylcarboxamide)