Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects.
Nayyar
Gaurav
G
Atherosclerosis Research Unit and Department of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Handattu
Shaila P
SP
Monroe
Candyce E
CE
Chaddha
Manjula
M
Datta
Geeta
G
Mishra
Vinod K
VK
Keenum
Tamara D
TD
Palgunachari
Mayakonda N
MN
Garber
David W
DW
Anantharamaiah
G M
GM
D000818:Animals; D001057:Apolipoproteins E / Q000737:chemistry / Q000172:deficiency / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D050197:Atherosclerosis / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D042783:Endothelial Cells / Q000187:drug effects*; D005260:Female; D056945:Hep G2 Cells; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D014280:Triglycerides / Q000097:blood
C478448:Ac-hE18A-NH(2); D001057:Apolipoproteins E; D019812:Heparan Sulfate Proteoglycans; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D010446:Peptide Fragments; D014280:Triglycerides; D002784:Cholesterol; D043303:Aryldialkylphosphatase