Validated hydrophilic interaction LC-MS/MS method for determination of N-methyl-2-pyrrolidinone residue: Applied to a depletion study of N-methyl-2-pyrrolidinone in swine liver following intramuscular administration of drug N-methyl-2-pyrrolidinone formulation.
Liu
Yanhong
Y
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, PR China. liuyh@gsstc.gov.cn
Ji
Yanhong
Y
Chen
Jiangtao
J
Chen
Ximing
X
Wang
Guangxiang
G
Shang
Youjun
Y
Liu
Xiangtao
X
Pan
Jack
J
D000097:Acetonitriles / Q000737:chemistry; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003903:Deuterium / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007273:Injections, Intramuscular; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine; D053719:Tandem Mass Spectrometry / Q000379:methods*
D000097:Acetonitriles; D011760:Pyrrolidinones; D003903:Deuterium; C038678:N-methylpyrrolidone; C032159:acetonitrile