title: Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
authors.affiliation: Department of Biology, Kalypsys Inc, San Diego, California, USA.
authors.forename: Kent T
authors.initials: KT
authors.lastname: Symons
authors.forename: Phan M
authors.initials: PM
authors.lastname: Nguyen
authors.forename: Mark E
authors.initials: ME
authors.lastname: Massari
authors.forename: John V
authors.initials: JV
authors.lastname: Anzola
authors.forename: Lena M
authors.initials: LM
authors.lastname: Staszewski
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Nahid
authors.initials: N
authors.lastname: Yazdani
authors.forename: Steven
authors.initials: S
authors.lastname: Dorow
authors.forename: Jerry
authors.initials: J
authors.lastname: Muhammad
authors.forename: Marciano
authors.initials: M
authors.lastname: Sablad
authors.forename: Natasha
authors.initials: N
authors.lastname: Rozenkrants
authors.forename: Celine
authors.initials: C
authors.lastname: Bonefous
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Payne
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Rix
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Shiau
authors.forename: Stewart A
authors.initials: SA
authors.lastname: Noble
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Smith
authors.forename: Christian A
authors.initials: CA
authors.lastname: Hassig
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tadimeti S
authors.initials: TS
authors.lastname: Rao
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D024841:Fluoroquinolones / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D055503:Protein Multimerization; D011719:Pyrazines / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity
chemical_list: C554421:4-((2-cyclobutyl-1H-imidazo(4,5-b)pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D011719:Pyrazines; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II