Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability.
Qin
Suofu
S
Retinal Disease Research, Department of Biological Sciences, Allergan, Inc., 2525 Dupont Drive, Irvine, CA 92612, USA. qin_suofu@allergan.com
Rodrigues
Gerard A
GA
D055372:AMP-Activated Protein Kinases / Q000502:physiology*; D000447:Aldehydes / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival; D002478:Cells, Cultured; D015853:Cysteine Proteinase Inhibitors / Q000633:toxicity*; D016207:Cytokines / Q000378:metabolism; D015536:Down-Regulation; D017097:Electric Impedance; D020868:Gene Silencing / Q000502:physiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D015227:Lipid Peroxidation / Q000502:physiology; D010766:Phosphorylation; D011720:Pyrazoles / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D034741:RNA, Small Interfering / Q000235:genetics; D055213:Retinal Pigment Epithelium / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology*; D014162:Transfection
D000447:Aldehydes; D015853:Cysteine Proteinase Inhibitors; D016207:Cytokines; D011720:Pyrazoles; D011743:Pyrimidines; D034741:RNA, Small Interfering; C516138:dorsomorphin; D006861:Hydrogen Peroxide; C526181:PRKAA2 protein, human; D055372:AMP-Activated Protein Kinases; C526180:PRKAA1 protein, human; C027576:4-hydroxy-2-nonenal