The identification of novel orally active mGluR5 antagonist GSK2210875.
The identification of novel orally active mGluR5 antagonist GSK2210875 is described.
Medicines Research Centre, Verona, Italy.
Maria
M
Pilla
Michela
M
Andreoli
Michela
M
Tessari
Sonia
S
Delle-Fratte
Adelheid
A
Roth
Sharon
S
Butler
Fiona
F
Brown
Parita
P
Shah
Ezio
E
Bettini
Palmina
P
Cavallini
Roberto
R
Benedetti
Doug
D
Minick
Paul
P
Smith
Ben
B
Tehan
Pier
P
D'Alessandro
Olivier
O
Lorthioir
Catherine
C
Ball
Vincenzo
V
Garzya
Caroline
C
Goodacre
Stephen
S
Watson
D000284:Administration, Oral; D000494:Allosteric Regulation; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051379:Mice; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
C556355:GSK2210875; C578936:Grm5 protein, mouse; C578937:Grm5 protein, rat; D006575:Heterocyclic Compounds, 3-Ring; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate