Factor V Leiden mutation and pregnancy-related complications.
OBJECTIVE
The objective of the study was to determine the prevalence of the factor V Leiden (FVL) mutation and its association with obstetric complications, blood loss during delivery, and venous thromboembolism (VTE).


METHODS
This was a prospective, observational, case-cohort study of 491 FVL carriers and 1055 controls derived from 6003 screened women. Data were analyzed with a Student t test and cross-tabulation.


RESULTS
FVL carriership prevalence was 8.3%. Gestational age at delivery, birthweight deviation, gestational hypertension, and preeclampsia incidences did not differ between groups. The incidences of placental abruption, neonatal asphyxia, eclampsia, intrauterine fetal death, intrapartum death, and unexplained late miscarriage were low. The incidence of major blood loss at delivery was lower in carriers. There were 3 VTEs among carriers and none among controls.


CONCLUSIONS
FVL carriership did not influence pregnancy-induced hypertension, birthweight, or prematurity but raised the risk of venous thromboembolism and lowered the risk of major blood loss.
Department of Obstetrics, Sahlgrenska University Hospital, and Section for the Health of Women and Children, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ulla
U
Kjellberg
Marianne
M
van Rooijen
Katarina
K
Bremme
Margareta
M
Hellgren
D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000235:genetics; D054556:Venous Thromboembolism / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V