[The pharmacokinetics study on Sinomenine transdermal patch on anaesthetized Beagle dogs].
OBJECTIVE
To explore the pharmacokinetic of Sinomenine transdermal patch.


METHODS
The plasma drug concentration of Beagle dogs was determined after administration with HPLC-UVD as analysis tools. The pharmacokinetics parameters were fitted with kinetica software package.


RESULTS
The exclusive analysis method was established with the following pharmacokinetics parameters: T (peak) = 8 h, Cmax = 366 ng/mL, MRT = 13 h. The pharmacokinetic characteristics was accordance with one-order rate and two-compartment model.


CONCLUSIONS
The method is preferable to be applied to the pharmacokinetics research and further applied pharmacological study which will play a reference role in clinical application.
Guangzhou University of TCM, Guangzhou 510006, China.
Ying-Feng
YF
Zhang
Yang
Y
Yu
Li-Ling
LL
Zhou
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D008297:Male; D023421:Models, Animal; D009019:Morphinans / Q000097:blood / Q000493:pharmacokinetics*; D032841:Sinomenium / Q000737:chemistry*; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D057968:Transdermal Patch
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D009019:Morphinans; C009271:sinomenine