PROMISCUOUS: a database for network-based drug-repositioning.
The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multi-specificity of approved drugs led to block-busters in new indication areas. Therefore, the interest in systematically elucidating new areas of application for known drugs is rising. Furthermore, the knowledge, understanding and prediction of so-called off-target effects allow a rational approach to the understanding of side-effects. With PROMISCUOUS we provide an exhaustive set of drugs (25,000), including withdrawn or experimental drugs, annotated with drug-protein and protein-protein relationships (21,500/104,000) compiled from public resources via text and data mining including manual curation. Measures of structural similarity for drugs as well as known side-effects can be easily connected to protein-protein interactions to establish and analyse networks responsible for multi-pharmacology. This network-based approach can provide a starting point for drug-repositioning. PROMISCUOUS is publicly available at http://bioinformatics.charite.de/promiscuous.
Charité - Universitätsmedizin Berlin, Institute for Physiology, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany. joachim.eichborn@charite.de
Joachim
J
von Eichborn
Manuela S
MS
Murgueitio
Mathias
M
Dunkel
Soeren
S
Koerner
Philip E
PE
Bourne
Robert
R
Preissner
D000547:Amantadine / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D016208:Databases, Factual; D015259:Dopamine Agents / Q000009:adverse effects / Q000494:pharmacology; D058492:Drug Repositioning; D008559:Memantine / Q000009:adverse effects / Q000494:pharmacology; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives; D000078785:Mirtazapine; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D025941:Protein Interaction Mapping; D011506:Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry
D000929:Antidepressive Agents, Tricyclic; D015259:Dopamine Agents; D004364:Pharmaceutical Preparations; D011506:Proteins; D008803:Mianserin; D000078785:Mirtazapine; D000547:Amantadine; D008559:Memantine