IL-12 and related cytokines: function and regulatory implications in Candida albicans infection.
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
The School of Dentistry, University of Queensland School of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, Australia. r.ashman@uq.edu.au
Robert B
RB
Ashman
Dipti
D
Vijayan
Christine A
CA
Wells
D056704:Adaptive Immunity; D000818:Animals; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity; D002177:Candidiasis / Q000276:immunology*; D004198:Disease Susceptibility; D006801:Humans; D018928:Immunity, Mucosal; D018664:Interleukin-12 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout
D018664:Interleukin-12