Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass.
BACKGROUND
Hemodynamic function may be depressed in the early postoperative stages after cardiac surgery. The aim of this study was the analysis of the myocardial contractility in neonates after cardiopulmonary bypass (CPB) and mild hypothermia.


METHODS
Three indices of left ventricular myocardial contractile function (dP/dt, (dP/dt)/P, and wall thickening) were studied up to 6 hours after CPB in neonatal piglets (CPB group; n = 4). The contractility data were analysed and then compared to the data of newborn piglets who also underwent median thoracotomy and instrumentation for the same time intervals but without CPB (non-CPB group; n = 3).


RESULTS
Left ventricular dP/dtmax and (dP/dtmax)/P remained stable in CPB group, while dP/dtmax decreased in non-CPB group 5 hours postoperatively (1761 ± 205 mmHg/s at baseline vs. 1170 ± 205 mmHg/s after 5 h; p < 0.05). However, with regard to dP/dtmax and (dP/dtmax)/P there were no statistically significant differences between the two groups. Comparably, although myocardial thickening decreased in the non-CPB group the differences between the two groups were not statistically significant.


CONCLUSIONS
The myocardial contractile function in survived neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia probably due to regional hypercontractility.
Department for Thoracic, Cardiac, and Vascular Surgery, Goettingen University, Goettingen, Germany. theodor.tirilomis@med.uni-goettingen.de
Theodor
T
Tirilomis
Oliver J
OJ
Liakopoulos
K Oguz
KO
Coskun
Marc
M
Bensch
Aron-Frederik
AF
Popov
Jan D
JD
Schmitto
Friedrich A
FA
Schoendube
D000818:Animals; D000831:Animals, Newborn; D002315:Cardiopulmonary Bypass; D007036:Hypothermia, Induced; D009200:Myocardial Contraction / Q000502:physiology*; D034421:Sus scrofa; D016277:Ventricular Function, Left / Q000502:physiology*