Concepts of neuroendocrine cardiology and neuroendocrine immunology, chemistry and biology of signal molecules.
Discovery of neurosecretion of cardioactive neurohormones produced by hypothalamic nuclei (NSO and NPV), as well as the biosynthesis of several immunomodulators (signal molecules of the neuroendocrine immune system of brain), deciphering of their chemical structure and study of their biological properties led to the foundation of two important trends of neurobiology: neuroendocrine immunology and cardiology. Hormone formation by atrium ganglionary nerve cells and auriculum establishment of neurohumoral interactions between hypothalamic and atrium neurosecretion indicated the existence of the system neuroendocrine hypothalamus--endocrine heart. Study of their biological properties promoted creation of powerful neurohormonal preparations for the treatment of immune, cardio-vascular, neurodegenerative, infectious and tumor diseases. Concepts suggested by us on neuroendocrine cardiology and immunology, create large perspectives for development of the theory and its implementation in medicine.
HKh Buniatian Institute of Biochemistry, NAS RA, 5/1 Sevak Str, Yerevan 0014, Armenia. galoyan@sci.am
Armen
A
Galoyan
D000486:Allergy and Immunology; D000818:Animals; D006321:Heart / Q000502:physiology*; D006801:Humans; D009490:Neurosecretory Systems / Q000378:metabolism*; D015398:Signal Transduction