Methotrimeprazine-induced corneal deposits and cataract revealed by urine drug profiling test.
Two schizophrenic patients who had been taking medication for a long period presented with visual disturbance of 6-month duration. Slit-lamp examination revealed fine, discrete, and brownish deposits on the posterior cornea. In addition, bilateral star-shaped anterior subcapsular lens opacities, which were dense, dust-like granular deposits, were noted. Although we strongly suspected that the patient might have taken one of the drugs of the phenothiazine family, we were unable to obtain a history of medications other than haloperidol and risperidone, which were taken for 3 yr. We performed a drug profiling test using urine samples and detected methotrimeprazine. The patient underwent surgery for anterior subcapsular lens opacities. Visual acuity improved in both eyes, but the corneal deposits remained. We report an unusual case of methotrimeprazine-induced corneal deposits and cataract in a patient with psychosis, identified by using the urine drug profiling test.
Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea.
Seong Taeck
ST
Kim
Jae Woong
JW
Koh
Joon Mo
JM
Kim
Won Young
WY
Kim
Gwang Ju
GJ
Choi
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use / Q000652:urine; D002386:Cataract / Q000139:chemically induced*; D003316:Corneal Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008728:Methotrimeprazine / Q000009:adverse effects* / Q000627:therapeutic use / Q000652:urine; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity
D014150:Antipsychotic Agents; D008728:Methotrimeprazine