Orofacial granulomatosis of the lip: a report of 2 cases with histological and immunohistochemical analyses and intralesional corticotherapy.
Orofacial granulomatosis is a generic term applied to manifestations of several diseases including sarcoidosis, Crohn's disease, Melkersson-Rosenthal syndrome, cheilitis granulomatosa of Miescher, tuberculosis and foreign-body reactions. What bonds these diseases together is the presence of noncaseating granulomas. A typical clinical manifestation of orofacial granulomatosis is recurrent labial swellings that eventually persist. This article describes 2 cases of OG diagnosed with the aid of immunohistochemical analysis and successfully treated with intralesional steroids.
Department of Oral Diagnosis, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
M Z
MZ
Martini
V C
VC
Galletta
E M
EM
Pereira
S C O M
SC
De Sousa
C A
CA
Lemos
D A
DA
Migliari
D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D051261:Granulomatosis, Orofacial / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015552:Injections, Intralesional; D008047:Lip Diseases / Q000188:drug therapy* / Q000473:pathology*; D014221:Triamcinolone / Q000008:administration & dosage*
D005938:Glucocorticoids; D014221:Triamcinolone