Is colonization with GBS in a previous pregnancy associated with adverse perinatal outcomes?
OBJECTIVE
To investigate whether colonization with GBS in a previous pregnancy is associated subsequently with adverse obstetric and perinatal outcomes.


METHODS
A retrospective study was undertaken comparing pregnancy complications of patients with and without colonization with GBS in a previous pregnancy from 1988 to 2006. Women with a positive GBS culture in the current pregnancy, women lacking prenatal care and multiple gestations were excluded from the analysis.


METHODS
Adverse obstetric and perinatal outcomes including premature rupture of membranes, intrapartum fever, chorioamnionitis and perinatal mortality.


RESULTS
Out of 184,266 singleton deliveries, 230 (0.12%) were of patients with a positive GBS culture in their previous pregnancy. Previous GBS colonization was not found to be associated with adverse pregnancy outcomes such as PROM (9.1 vs. 6.8%; P = 0.16), intrapartum fever (1.3 vs. 2.2%; P = 0.72) and chorioamnionitis (1.3 vs. 0.8%; P = 0.29).


CONCLUSIONS
GBS colonization in a previous pregnancy is not associated with adverse pregnancy outcomes in the current pregnancy.
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Adi Y
AY
Weintraub
Roy
R
Kessous
Ruslan
R
Sergienko
Shimrit
S
Salem Yaniv
Fernanda
F
Press
Arnon
A
Wiznitzer
Eyal
E
Sheiner
D000328:Adult; D002821:Chorioamnionitis / Q000453:epidemiology / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007557:Israel / Q000453:epidemiology; D008297:Male; D054238:Perinatal Mortality; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000209:etiology; D013292:Streptococcus agalactiae / Q000302:isolation & purification*