A review and meta-analysis of studies on the effect and timing of β-blocker administration in patients with ST-segment elevation myocardial infarction.
The utility of β-blockers during an evolving ST-segment elevation myocardial infarction (STEMI) has substantial theoretic physiological backing. This coupled with early successes using β-blockers in STEMI promulgated multiple guidelines expanding the use of this class of medication to all patients with acute coronary syndromes. However, recent studies have questioned the utility of β-blockers in the emergency department in these patients. The purpose of this article is to review the evidence behind the use of β-blockers in the emergency department for STEMI patients.
Deparmtent of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.
Lorenzo
L
Paladino
Richard
R
Sinert
Ethan
E
Brandler
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D004635:Emergency Medicine / Q000379:methods*; D004638:Emergency Treatment / Q000379:methods*; D019317:Evidence-Based Medicine; D017052:Hospital Mortality; D006801:Humans; D007262:Infusions, Intravenous; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D016017:Odds Ratio; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D012107:Research Design; D013997:Time Factors; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists