Urease inhibitors from Indigofera gerardiana Wall.
Three new phloroglucinol type compounds Indigoferin-A (1), Indigoferin-B (2) and Indigoferin-C (3), along with a known compound β-sitosterol were isolated from the Indegofera gerardiana Wall. The structures of Indigoferin-A (1), Indigoferin-B (2), and Indigoferin-C (3) were deduced on the basis of spectroscopic techniques (EI-MS, HREI-MS, (1)H NMR, (13)C NMR, HMQC, and HMBC). The urease inhibition studies on all the four compounds have also been carried out.
Department of Pharmacology Khyber Medical College, Peshawar, Pakistan.
Shafiq Ahmad
SA
Tariq
Muhammad Nisar
MN
Ahmad
Obaidullah
Ajmal
A
Khan
Muhammad Iqbal
MI
Choudhary
Waqar
W
Ahmad
Manzoor
M
Ahmad
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029883:Indigofera / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008362:Mannosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors*
C568906:2-(hydroxymethyl)-6-(4-(5-methylhexyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol; C568905:6-methyl-1-(4-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)phenyl)heptan-1-one; D004791:Enzyme Inhibitors; D006027:Glycosides; D007659:Ketones; D008362:Mannosides; D010936:Plant Extracts; C568907:indigoferin-C; D010696:Phloroglucinol; D014510:Urease