Polymethyl-methacrylate-sorbitol-based capsules as local drug delivery vehicles: a preliminary study.
Local delivery of antibiotics via PMMA (polymethyl-methacrylate) has been widely used in the treatment of chronic osteomyelitis for over 40 years. Unfortunately, PMMA is water insoluble, which seriously limits antibiotic delivery. In addition, the polymerization temperature of PMMA is high, and consequently, only heat-stable antibiotics can be used. Therefore our aim has been to develop an effective antibiotic delivery system, which can be loaded with a wide variety of drugs and deliver the molecules in a predictable manner. Capsules with wall thicknesses of 0.3-0.6 mm from PMMA mixtures containing 40-70 w/w% (weight percent) of sorbitol were prepared and their permeability tested with BPB (Bromophenol Blue). Sorbitol content and wall thickness correlated with the BPB release. SEM (scanning electron microscopy) showed that the canalization of capsules also was well correlated with both sorbitol content and wall thickness. The PMMA-sorbitol-based capsule can potentially be a versatile tool in assuring effective delivery of antibiotics and other substances.
Department of Laboratory Medicine, Faculty of Medicine, University of Pécs, Ifjúság u. 13, Pécs, Hungary.
Dorottya
D
Frank
Gellért
G
Cseh
Tamás
T
Nagy
László
L
Pótó
Béla
B
Kocsis
Attila
A
Miseta
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002214:Capsules / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D010539:Permeability; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013012:Sorbitol / Q000737:chemistry*; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D013012:Sorbitol; D019904:Polymethyl Methacrylate