The role of enamel matrix derivative protein in minimally invasive surgery in treating intrabony defects in single-rooted teeth: a randomized clinical trial.
BACKGROUND
This study investigates the impact of enamel matrix derivative (EMD) proteins on the outcome of a minimally invasive surgical technique (MIST) for the treatment of intrabony defects.


METHODS
Thirty patients who presented with intrabony defects were randomly assigned to treatment with: 1) MIST plus EMD or 2) MIST alone. Probing depth (PD), position of the gingival margin (PGM), and relative clinical attachment level (RCAL) were evaluated at 3 and 6 months after treatment. Radiographs and markers in gingival crevicular fluid associated with periodontal regeneration were also evaluated.


RESULTS
Significant PD reductions, RCAL gains, and no changes in PGM were obtained at 3 and 6 months in both groups. Clinical and radiographic evaluations and levels of mediators of wound healing did not present differences between therapies at any time.


CONCLUSIONS
The use of EMD did not provide superior benefits on the outcome of the minimally invasive surgical approach for the treatment of intrabony defects.
Department of Prosthodontics and Periodontics, School of Dentistry at Piracicaba, University of Campinas, Piracicaba, SP, Brazil.
Fernanda V
FV
Ribeiro
Renato C V
RC
Casarin
Francisco H N
FH
Júnior
Enilson A
EA
Sallum
Márcio Z
MZ
Casati
D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D017622:Periodontal Attachment Loss / Q000000981:diagnostic imaging / Q000628:therapy; D011446:Prospective Studies; D011859:Radiography; D016037:Single-Blind Method; D014092:Tooth Root; D016896:Treatment Outcome
D018786:Bone Substitutes; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins