Kaposi's sarcoma after repeated surgical procedures in an immunocompetent patient: the lymphatic hypothesis.
A 63-year-old Swiss patient developed acquired nodules on his right palm after 3 localized surgeries, called 'needle fasciotomy', for Dupuytren's disease. Kaposi's sarcoma (KS) was diagnosed in a biopsy of a nodule. A positive immunolabeling and serology for human herpesvirus 8 has been found, but human immunodeficiency virus and hepatitis C identification remained negative. The nodules were limited to the surgically traumatized area. This first report of a nonimmunocompromised patient developing a KS after repeated surgeries in a unique peculiar localized area with a dense lymphatic network sustains the hypothesis that tissue alterations involving the lymphatic system could play a central role in the occurrence of KS.
Department of Dermatology, Geneva University Hospital, Geneva, Switzerland. mariakostak@yahoo.com
M
M
Kostaki
X C
XC
Pham
L
L
Toutous-Trellu
V
V
Piguet
G
G
Kaya
J H D
JH
Fasel
B V
BV
Stimec
M
M
Becker
D
D
Salomon
D000634:Aminoquinolines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D004387:Dupuytren Contracture / Q000276:immunology / Q000601:surgery* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D000077271:Imiquimod; D007121:Immunocompetence / Q000276:immunology; D008208:Lymphatic System / Q000187:drug effects / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D016896:Treatment Outcome
D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod