Hyperoxia-induced alterations in cardiovascular function and autonomic control during return to normoxic breathing.
Hyperoxia causes hemodynamic alterations. We hypothesized that cardiovascular and autonomic control changes last beyond the end of hyperoxic period into normoxia. Ten healthy volunteers were randomized to breathe either medical air or 100% oxygen for 45 min in a double-blind study design. Measurements were performed before (baseline) and during gas exposure, and then 10, 30, 60, and 90 min after gas exposure. Hemodynamic changes were studied by Doppler echocardiography. Changes in cardiac and vasomotor autonomic control were evaluated through changes in spectral power of heart rate variability and blood pressure variability. Cardiac baroreflex sensitivity was assessed by the sequence method. Hyperoxia significantly decreased heart rate and increased the high frequency power of heart rate variability, suggesting a chemoreflex increase in vagal activity since the slope of cardiac baroreflex was significantly decreased during hyperoxia. Hyperoxia increased significantly the systemic vascular resistances and decreased the low frequency power of blood pressure variability, suggesting that hyperoxic vasoconstriction was not supported by an increase in vascular sympathetic stimulation. These changes lasted for 10 min after hyperoxia (p < 0.05). After the end of hyperoxic exposure, the shift of the power spectral distribution of heart rate variability toward a pattern of increased cardiac sympathetic activity lasted for 30 min (p < 0.05), reflecting a resuming of baseline autonomic balance. Cardiac output and stroke volume were significantly decreased during hyperoxia and returned to baseline values (10 min) later than heart rate. In conclusion, hyperoxia effects continue during return to normoxic breathing, but cardiac and vascular parameters followed different time courses of recovery.
Département des Environnements Opérationnels-Environnements Extrêmes, Institut de Recherche Biomédicale des Armées (IRBA)-Antenne Toulon, Boulevard Sainte Anne BP 20548, 83041 Toulon Cedex 9, France. goleyoann@aol.com
Yoann
Y
Gole
Ombeline
O
Gargne
Mathieu
M
Coulange
Jean-Guillaume
JG
Steinberg
Malika
M
Bouhaddi
Yves
Y
Jammes
Jacques
J
Regnard
Alain
A
Boussuges
D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D017704:Baroreflex / Q000502:physiology; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000502:physiology; D000072038:Cardiac Rehabilitation; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D004311:Double-Blind Method; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D018496:Hyperoxia / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D012119:Respiration