Gas chromatographic/mass spectrometric evidence for the identification of 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline as a normal constituent of rat brain. Its quantification and comparison to rat whole brain levels of dopamine.
Gas chromatographic/mass spectrometric data are presented which demonstrate the presence of 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (DHTIQ) as a normal constituent of rat brain. The level of DHTIQ was calculated to be 10.0 +/- 3.0 ng/g wet weight (+/- S.D., N = 9) of brain tissue while the level of dopamine (DA) was measured as 1.22 +/- 0.22 microg/g (N = 14). The ratio of DHTIQ:DA was thus observed to be approximately 1:100. The possible formation of DHTIQ in alcoholism and schizophrenia is discussed.
The Neurosciences Program, Department of Psychiatry, University of Alabama in Birmingham, Birmingham, AL 35294, USA.
S A
SA
Barker
J A
JA
Monti
L C
LC
Tolbert
G B
GB
Brown
S T
ST
Christian
D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry; D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D002849:Chromatography, Gas / Q000379:methods*; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D044005:Tetrahydroisoquinolines / Q000032:analysis* / Q000737:chemistry
D000470:Alkaloids; D044005:Tetrahydroisoquinolines; C024133:heliamine; D004298:Dopamine