Pathogen sensing, subsequent signalling, and signalosome in human platelets.
Beyond haemostasis, platelets exert a potent role in innate immunity and particularly in its inflammatory arm. The extent of this action remains however debatable, despite clear - and old - evidence of a link between platelets and infection. Platelets can sense infectious pathogens by pathogen recognition receptors and they can even discriminate between various types of infectious signatures. In reply, they can shape their capacity to respond by activating a signalosome and by producing different profiles of pro-inflammatory cytokines and related products. The links between pathogen sensing, signalosome activation and protein production, and their finely tuned regulation are still under investigation since platelets lack a nucleus and thus, canonical molecular biology and genomics apparati.
Etablissement Français du Sang Auvergne-Loire & EA 3064, Faculty of Medicine, University of Saint-Etienne, a Member of the University of Lyon, France. olivier.garraud@efs.sante.fr
Olivier
O
Garraud
Julien
J
Berthet
Hind
H
Hamzeh-Cognasse
Fabrice
F
Cognasse
D001792:Blood Platelets / Q000276:immunology* / Q000382:microbiology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D015398:Signal Transduction
D016207:Cytokines