Synthesis and antiviral activities of synthetic glutarimide derivatives.
A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China.
Xing-yue
XY
Ji
Zhao-jin
ZJ
Zhong
Si-tu
ST
Xue
Shuai
S
Meng
Wei-ying
WY
He
Rong-mei
RM
Gao
Yu-huan
YH
Li
Zhuo-rong
ZR
Li
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003384:Coxsackievirus Infections / Q000188:drug therapy*; D029822:Enterovirus B, Human / Q000187:drug effects*; D006561:Herpes Simplex / Q000188:drug therapy*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects*; D015394:Molecular Structure; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D010881:Piperidones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000998:Antiviral Agents; D010881:Piperidones; C007864:glutarimide