The treatment effect of the burn wound healing by electrolytic-reduction ion water lotion combination therapy. Part 2: Two degree burn of forearm to the dorsum of the hand.
Patient 1: A 1-year-and-3-month-old boy suffered a burn injury extending from the left forearm to hand due to boiling water. An extensive skin defect from the left forearm to the dorsum of the hand was observed, and an IIb-III degree burn was diagnosed. Treatment of the burn was started with the application of electrolytic-reduction ion water (ERI) lotion, antibiotic/steroid combination ointment, and vitamin A/E ointment with wrap therapy. Two days after the initiation of therapy, redness and swelling were still observed despite a slight decrease in swelling. After 21 days, skin redness decreased, and there was no functional impairment. After 74 days, the skin color was almost normal, and no functional impairment was observed, showing a favorable course. Patient 2: An 8.5-month-old girl suffered a burn injury extending from the fingers to dorsum of the right hand and right wrist due to boiling water. There was an extensive skin defect accompanied by bulla formation extending from the fingers and dorsum of the right hand. An II-degree burn was diagnosed. Treatment of the burn was started treatment similar to the Patient 1. Bulla decreased, but redness and swelling were still present 2-8 days after the initiation of therapy. After 16-25 days, both skin redness and swelling decreased. After 30 days, the epithelialization of the dorsum of the hand had almost completed. After 60 days, the skin color was nearly normal, and there was no functional impairment, showing a favorable course. In these patients, burn wounds completely healed without hypertrophic or keloid scar formation or pigmentation. These results suggest that extensive II-III burns can be adequately treated by this topical therapy.
Department of Pharmaceutical Sciences, Meiji Pharmaceutical University, Tokyo, Japan.
Tetsuo
T
Shu
Masahiro
M
Okajima
Yuko
Y
Wada
Ken-ichi
K
Shimokawa
Fumiyoshi
F
Ishii
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D004338:Drug Combinations; D004572:Electrolysis; D005260:Female; D006801:Humans; D007223:Infant; D007477:Ions / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009824:Ointments / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D014801:Vitamin A / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use; D014867:Water / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D007477:Ions; D009824:Ointments; D013256:Steroids; D014867:Water; D014801:Vitamin A; D014810:Vitamin E; C048974:vitamin A, vitamin E drug combination