ThYme: a database for thioester-active enzymes.
The ThYme (Thioester-active enzYme; http://www.enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. These enzymes are active on thioester-containing substrates, specifically those that are parts of the acyl-CoA synthase, acyl-CoA carboxylase, acyl transferase, ketoacyl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme groups. These groups have been classified into families, members of which are similar in sequences, tertiary structures and catalytic mechanisms, implying common protein ancestry. ThYme is continually updated as sequences and tertiary structures become available.
Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, USA.
David C
DC
Cantu
Yingfei
Y
Chen
Matthew L
ML
Lemons
Peter J
PJ
Reilly
D000217:Acyltransferases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D000595:Amino Acid Sequence; D019735:Carbon-Carbon Ligases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D020134:Catalytic Domain; D030562:Databases, Protein; D005227:Fatty Acids / Q000096:biosynthesis*; D006836:Hydro-Lyases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D008025:Ligases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D018942:Macrolides / Q000378:metabolism*; D010088:Oxidoreductases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D017434:Protein Structure, Tertiary; D013869:Thiolester Hydrolases / Q000737:chemistry / Q000145:classification / Q000378:metabolism
D005227:Fatty Acids; D018942:Macrolides; D010088:Oxidoreductases; D000217:Acyltransferases; D013869:Thiolester Hydrolases; D006836:Hydro-Lyases; D008025:Ligases; D019735:Carbon-Carbon Ligases; C018757:acyl-CoA carboxylase