MicroRNA regulation of neural stem cells and neurogenesis.
MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.
Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA. yshi@coh.org
Yanhong
Y
Shi
Xinyu
X
Zhao
Jenny
J
Hsieh
Hynek
H
Wichterle
Soren
S
Impey
Sourav
S
Banerjee
Pierre
P
Neveu
Kenneth S
KS
Kosik
D000818:Animals; D044127:Epigenesis, Genetic / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D035683:MicroRNAs