[Synthesis and degradation of hyaluronic acid by bacteria of Streptococcus genus].
Modern data on metabolism of hyaluronic acid by bacteria from Streptococcus genus are presented. Several species of bacteria forming capsule from hyaluronic acid, which is analogous to glycosaminoglycan of vertebrates, are considered. Different aspects of hyaluronic acid synthesis are described: biochemical synthesis pathway, genetic basis, regulation of expression of genes belonging to hyaluronic acid synthesis operon. Biological role and physiologic importance of hyaluronic acid for bacteria, including its role in overcoming immune barrier by pathogenic species, are discussed. Process of depolymerization of hyaluronic acid in presence of hyaluronatlyases secreted by certain streptococci is considered. Characteristic of streptococcal enzyme hyaluronatlyase, its mechanism of catalytic effect, and biological function are presented.
A V
AV
Beloded
I I
II
Samoĭlenko
R N
RN
Tsepilov
D000818:Animals; D016667:Bacterial Capsules / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D009876:Operon; D011133:Polysaccharide-Lyases / Q000378:metabolism*; D013290:Streptococcal Infections / Q000382:microbiology*; D013291:Streptococcus / Q000201:enzymology* / Q000235:genetics
D006820:Hyaluronic Acid; D011133:Polysaccharide-Lyases; C100002:hyaluronate lyase