Cyclodextrin-based gene delivery systems.
Cyclodextrin (CD) history has been largely dominated by their unique ability to form inclusion complexes with guests fitting in their hydrophobic cavity. Chemical funcionalization was soon recognized as a powerful mean for improving CD applications in a wide range of fields, including drug delivery, sensing or enzyme mimicking. However, 100 years after their discovery, CDs are still perceived as novel nanoobjects of undeveloped potential. This critical review provides an overview of different strategies to promote interactions between CD conjugates and genetic material by fully exploiting the inside-outside/upper-lower face anisotropy of the CD nanometric platform. Covalent modification, self-assembling and supramolecular ligation can be put forward with the ultimate goal to build artificial viruses for programmed and efficient gene therapy (222 references).
Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, E-41071 Sevilla, Spain. mellet@us.es
Carmen
C
Ortiz Mellet
José M
JM
García Fernández
Juan M
JM
Benito
D003505:Cyclodextrins / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D050091:Dendrimers / Q000737:chemistry; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
D003505:Cyclodextrins; D050091:Dendrimers; D011108:Polymers; D004247:DNA