Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk.
Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associated with increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by new data and by meta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95% Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P < 0.0001). However, the odds ratio is relatively small.
Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.
Marie-Louise
ML
Lehmann
Silvia
S
Selinski
Meinolf
M
Blaszkewicz
Michael
M
Orlich
Daniel
D
Ovsiannikov
Oliver
O
Moormann
Christoph
C
Guballa
Alexander
A
Kress
Michael C
MC
Truss
Holger
H
Gerullis
Thomas
T
Otto
Dimitri
D
Barski
Günter
G
Niegisch
Peter
P
Albers
Sebastian
S
Frees
Walburgis
W
Brenner
Joachim W
JW
Thüroff
Miriam
M
Angeli-Greaves
Thilo
T
Seidel
Gerhard
G
Roth
Holger
H
Dietrich
Rainer
R
Ebbinghaus
Hans M
HM
Prager
Hermann M
HM
Bolt
Michael
M
Falkenstein
Anna
A
Zimmermann
Torsten
T
Klein
Thomas
T
Reckwitz
Hermann C
HC
Roemer
Dietrich
D
Löhlein
Wobbeke
W
Weistenhöfer
Wolfgang
W
Schöps
Anwer E
AE
Beg
Muhammad
M
Aslam
Gergely
G
Bánfi
Imre
I
Romics
Katja
K
Ickstadt
Holger
H
Schwender
Andreas
A
Winterpacht
Jan G
JG
Hengstler
Klaus
K
Golka
D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005796:Genes; D005858:Germany; D006801:Humans; D006814:Hungary; D008297:Male; D016017:Odds Ratio; D010154:Pakistan; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012907:Smoking / Q000009:adverse effects / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics*; D014687:Venezuela
C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins