Estrogen antagonist and development of macular hole.
To describe the clinical and optical coherence tomography (OCT) features of a macular hole (MH) or its precursor lesion in patients treated with systemic antiestrogen agents. We reviewed the medical history of the patient, ophthalmic examination, and both fundus and OCT findings. Three female patients receiving antiestrogen therapy sought treatment for visual disturbance. All of the patients showed foveal cystic changes with outer retinal defect upon OCT. Visual improvement was achieved through surgery for the treatment of MH in two patients. Antiestrogen therapy may result in MH or its precursor lesion, in addition to perifoveal refractile deposits. OCT examination would be helpful for early detection in such cases.
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Song Ee
SE
Chung
Seong Wook
SW
Kim
Hye Won
HW
Chung
Se Woong
SW
Kang
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012167:Retinal Perforations / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D013629:Tamoxifen / Q000009:adverse effects*; D014821:Vitrectomy
D004965:Estrogen Antagonists; D013629:Tamoxifen