Epidemics of acute renal failure in children (diethylene glycol toxicity).
Acute renal failure in children can have a variety of causes. There have been several epidemics of acute renal failure affecting predominantly young children where the cause has been diethylene glycol (DEG) poisoning. These children have presented with gastrointestinal bleeding, seizures and liver failure as well as renal failure. The poisoning has been the result of either contamination of the medicinal products by DEG or the deliberate illegal use of DEG as a solvent. More than 300 children worldwide have died from DEG poisoning. Health professionals need to be aware of the clinical presentation of DEG poisoning as prompt action is likely to save lives by the removal of the contaminated/illegal medicine from pharmacies and shops in the affected area.
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3DT, UK; mzxsa2@nottingham.ac.uk
Saad
S
Alkahtani
Helen
H
Sammons
Imti
I
Choonara
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D058110:Counterfeit Drugs / Q000506:poisoning; D004340:Drug Contamination; D058872:Epidemics; D005026:Ethylene Glycols / Q000506:poisoning*; D006801:Humans; D012997:Solvents / Q000506:poisoning
D058110:Counterfeit Drugs; D005026:Ethylene Glycols; D012997:Solvents; C013484:diethylene glycol