PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins.
The polyglutamine diseases are caused in part by a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of β-sheet rich aggregates. Recent evidence suggests that the misfolding mechanism is context-dependent, and that properties of the host protein, including the domain architecture and location of the repeat tract, can modulate aggregation. In order to allow the bioinformatic investigation of the context of polyglutamines, we have constructed a database, PolyQ (http://pxgrid.med.monash.edu.au/polyq). We have collected the sequences of all human proteins containing runs of seven or more glutamine residues and annotated their sequences with domain information. PolyQ can be interrogated such that the sequence context of polyglutamine repeats in disease and non-disease associated proteins can be investigated.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.
Amy L
AL
Robertson
Mark A
MA
Bate
Steve G
SG
Androulakis
Stephen P
SP
Bottomley
Ashley M
AM
Buckle
D030562:Databases, Protein; D004194:Disease; D006801:Humans; D010455:Peptides / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D020449:Repetitive Sequences, Amino Acid; D020539:Sequence Analysis, Protein
D010455:Peptides; D011506:Proteins; C097188:polyglutamine