Hyperbranched polyglycerols on the nanometer and micrometer scale.
We report the preparation of polyglycerol particles on different length scales by extending the size of hyperbranched polyglycerols (3 nm) to nanogels (32 nm) and microgels (140 and 220 μm). We use miniemulsion templating for the preparation of nanogels and microfluidic templating for the preparation of microgels, which we obtain through a free-radical polymerization of hyperbranched polyglycerol decaacrylate and polyethylene glycol-diacrylate. The use of mild polymerization conditions allows yeast cells to be encapsulated into the resultant microgels with cell viabilities of approximately 30%.
Free University Berlin, Institute for Chemistry and Biochemistry, Berlin, Germany.
Dirk
D
Steinhilber
Sebastian
S
Seiffert
John A
JA
Heyman
Florian
F
Paulus
David A
DA
Weitz
Rainer
R
Haag
D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry*; D005990:Glycerol / Q000009:adverse effects / Q000737:chemistry*; D008863:Microspheres; D000080385:Nanogels; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000737:chemistry*; D011094:Polyethyleneimine / Q000009:adverse effects / Q000737:chemistry*; D011108:Polymers / Q000009:adverse effects / Q000737:chemistry*; D015003:Yeasts / Q000166:cytology / Q000187:drug effects
D001672:Biocompatible Materials; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; C043941:polyglycerol; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D005990:Glycerol