First total synthesis of (-)- and (+)-6-O-desmethylantofine.
The first total synthesis of (-)-6-O-desmethylantofine (A) and its unnatural enantiomer (+)-6-O-desmethylantofine (B) is described. The synthetic route is efficient and practical with easily available glutamic acid dimethyl ester hydrochloride as the chiral material under mild conditions.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People's Republic of China.
Meng
M
Wu
Ling
L
Li
Bo
B
Su
Zhihui
Z
Liu
Qingmin
Q
Wang
D007212:Indolizines / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D010618:Phenanthrolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D007212:Indolizines; D007546:Isoquinolines; D010618:Phenanthrolines