Evaluation of oxidative and nitrosative stress in hemodialysis patients.
OBJECTIVE
Oxidative/nitrosative stress has long been demonstrated in hemodialysis patients. It is associated with numerous complications such as atherosclerosis and related cardiovascular disturbances. However, the factors influencing oxidative/nitrosative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the alteration of oxidative/nitrosative stress parameters and total antioxidant status.


METHODS
Forty-one hemodialysis patients and 41 healthy subjects were enrolled in the present study. Serum myeloperoxidase, nitrotyrosine and total antioxidant capacity were determined.


RESULTS
Serum myeloperoxidase and nitrotyrosine were significantly higher in the haemodialysis patients compared to the healthy subjects (P<0.05) while total antioxidant capacity was lower (P<0.01).


CONCLUSIONS
According to the results of this study, oxidative and nitrosative stress is increased in haemodialysis patients, therefore these alterations should be considered in the treatment of these patients.
Department of Biochemistry, Faculty of Medicine, University of Gaziantep Gaziantep, Turkey. enamiduru@gmail.com
E S
ES
Namiduru
M
M
Tarakcioglu
O
O
Tiryaki
C
C
Usalan
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D009195:Peroxidase / Q000097:blood*; D006435:Renal Dialysis; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; C002744:3-nitrotyrosine; D014443:Tyrosine; D009195:Peroxidase