Homeostatic plasticity: single hippocampal neurons see the light.
Neurons adapt to altered network activity through homeostatic changes in synaptic function. In this issue of Neuron, Goold and Nicoll report that chronic hyperactivation of individual CA1 pyramidal neurons drives cell-autonomous, compensatory synapse elimination via CaMKIV-dependent transcription. These findings suggest that neurons gauge their intrinsic activity to instruct homeostatic regulation of synaptic inputs.
Molecular and Behavioral Neuroscience Institute and Department of Molecular and Integrative Physiology, University of Michigan, 5067 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. masutton@umich.edu
Michael A
MA
Sutton