Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation.
TA-TMA is a serious complication of hematopoietic stem cell transplantation, presenting as microangiopathic hemolytic anemia with severe renal injury and mortality as high as 60%. Diagnosis and treatment of TA-TMA is very challenging after HSCT because anemia, thrombocytopenia, hypertension, and renal impairment are multifactorial, leading to delayed recognition and management of this complication. We report a successful outcome following early intervention for hyperacute TA-TMA after allogeneic HSCT.
Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH 45229, USA. sonata.jodele@cchmc.org
Sonata
S
Jodele
Jack J
JJ
Bleesing
Parinda A
PA
Mehta
Alexandra H
AH
Filipovich
Benjamin L
BL
Laskin
Jens
J
Goebel
Susan L
SL
Pinkard
Stella M
SM
Davies
D002675:Child, Preschool; D061345:Early Medical Intervention; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000628:therapy; D057049:Thrombotic Microangiopathies / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy