[Non-alcoholic steatosis/steatohepatitis -- 2010].
Non-alcoholic steatosis/steatohepatitis is the most common etiology of abnormal liver function tests. Authors review the etiology, pathomechanism and clinical signs. Possibilities of the diagnosis are also summarized. There is an increasing need to find non-invasive biomarkers (TNF-α, adiponektin, end product of lipid peroxidation, cytokeratin-18, hyaluronic acid), score systems (Fibrotest, APRI), methods (Fibroscan), which would detect the progression of the disease, the development of inflammation and fibrosis. There is no proven specific therapy; the aim is the elimination of provoking factors (weight loss), treatment of diabetes mellitus and hyperlipidemia. Besides, liver protection (antioxidants) is important, as well.
Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088. hagymasikriszti@freemail.hu
Krisztina
K
Hagymási
Gabriella
G
Lengyel
D000975:Antioxidants / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D031204:Caloric Restriction; D018450:Disease Progression; D005234:Fatty Liver / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D000960:Hypolipidemic Agents / Q000008:administration & dosage; D007333:Insulin Resistance; D008019:Life Style; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D016031:Liver Transplantation; D020011:Protective Agents / Q000008:administration & dosage; D014280:Triglycerides / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D020011:Protective Agents; D014280:Triglycerides