Injectable disease-modifying therapy for relapsing-remitting multiple sclerosis: a review of adherence data.
Long-term adherence to disease-modifying therapy in relapsing-remitting multiple sclerosis (RRMS) is associated with improved patient outcomes, including a reduced risk of relapse and a better preserved quality of life. However, the unpredictable nature of the disease--even when it is being treated--may make it difficult to convince patients of the importance of treatment adherence. A number of studies have attempted to pinpoint factors that affect adherence. Nursing interventions that address some of these factors may improve adherence and, thus, the disease course for a variety of RRMS patients. This article summarizes literature that approximates the prevalence and impact of nonadherence and reviews factors identified in clinical trials that affect adherence. Nursing interventions that can improve adherence, including telephone counseling and motivational interview techniques, are also addressed.
Multiple Sclerosis Center at Wayne State University School of Medicine, Detroit, MI, USA. crcaon@med.wayne.edu
Christina
C
Caon
Carol
C
Saunders
Jennifer
J
Smrtka
Nancy
N
Baxter
Jennifer
J
Shoemaker
D018501:Antirheumatic Agents / Q000627:therapeutic use*; D006293:Health Promotion; D006801:Humans; D007279:Injections, Subcutaneous / Q000451:nursing / Q000523:psychology; D055118:Medication Adherence / Q000523:psychology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000451:nursing / Q000523:psychology; D024802:Nurse's Role; D010353:Patient Education as Topic; D011788:Quality of Life / Q000523:psychology; D012008:Recurrence; D012074:Remission Induction; D012646:Self Administration / Q000451:nursing / Q000523:psychology; D020377:Self Efficacy; D016903:Drug Monitoring
D018501:Antirheumatic Agents