Thalamus abnormalities during working memory in schizophrenia. An fMRI study.
We aimed to identify and compare cerebral activations in schizophrenia patients and controls during a working memory (WM) task at the same performance level for both a verbal and a spatial task. Whereas the performances of the patients (n=22) and controls (n=15) were similar, cerebral activations were significantly increased in the patients, particularly in the thalamus/basal ganglia for the two tasks and in regions of the prefrontal cortex and the cerebellum for the spatial task only. Our results suggest that stronger activations of deep brain structures in patients may be the result from a compensating mechanism for WM difficulties.
Université de Lyon, Lyon, F-69003, France.
Julie
J
Bor
Jérôme
J
Brunelin
Dominique
D
Sappey-Marinier
Danielle
D
Ibarrola
Thierry
T
d'Amato
Marie-Françoise
MF
Suaud-Chagny
Mohamed
M
Saoud
D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology*; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D012559:Schizophrenia / Q000150:complications; D013788:Thalamus / Q000098:blood supply* / Q000473:pathology*; D055815:Young Adult
D010100:Oxygen