[A related heredity epidemiological research on allergic rhinitis and asthma in Nantong region].
OBJECTIVE
To discuss the related impact of genetic factors in the incidence of bronchial asthma (BA) and allergic rhinitis (AR) in Nantong region, China.


METHODS
By random sampling method, investigation and research on the incidence of genetic epidemiology were carried out in the population of 95 300 on AR and BA.


RESULTS
The rate of patients with allergic rhinitis with asthma was 25.92% (296/1142), the rate of asthma patients with allergic rhinitis was 40.49% (296/731). The prevalences of AR complicated with BA were 8.19% (280/3418), 3.08% (154/5002) and 3.16% (85/2687) in the first-, second-and third-degree relatives of the probands respectively, while the prevalences of BA complicated with AR were 15.81% (466/2947), 4.61% (229/4967) and 2.51% (134/5345) in the first-, second- and third-degree relatives of the probands respectively, higher than those in the controls (P < 0.05). The weighted mean heritability of AR in BA patients was 94.2% ± 1.9%, while the weighted mean heritability of BA in AR patients was 81.8% ± 2.1%, more than 60%, suggesting that both AR and BA were relevant with genetics.


CONCLUSIONS
The incidence of BA and AR has obvious relevance, supporting the theory that the two diseases are an united airway disease and relevant with polygene heredity.
Department of Otorhinolaryngology, Second Affiliated Hospital, Nantong University, Nantong 226001, China. entmali@sina.com
Li
L
Ma
Da-ling
DL
Chen
Ru-xin
RX
Zhang
Xiao-lei
XL
Wang
Yun-jian
YJ
Shi
Chao
C
Ji
Zhi-jun
ZJ
Huang
Mao-hua
MH
Qian
Gang
G
Gao
Yong-juan
YJ
Huang
Pei
P
Guan
D001249:Asthma / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010375:Pedigree; D015995:Prevalence; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*