Can inhaled corticosteroids prevent asthma exacerbations?
OBJECTIVE
asthma exacerbations occur unpredictably, are a cause of morbidity and mortality, and contribute significantly to increased healthcare costs. Inhaled corticosteroids reduce exacerbations and improve quality of life.


RESULTS
the aetiopathology of asthma exacerbations is heterogeneous. Attempts to phenotype the heterogeneity of the pattern of airway inflammation by noninvasive monitoring of airway inflammation has identified a subgroup of patients with eosinophilic inflammation who are most likely to respond to steroid therapy. Strategies directed to normalize eosinophilic airway inflammation with corticosteroids have consistently led to a marked reduction in exacerbations. In contrast, their role in modulating the natural history of disease is less certain.


CONCLUSIONS
in the near future, improvements in our understanding of the mechanisms of exacerbations may identify therapeutic targets. While we await these developments, inhaled corticosteroids remain the first choice anti-inflammatory therapy for asthma.
Department of Infection, Inflammation and Immunity, Institute of Lung Health, University of Leicester, Leicester, UK.
Dhananjay
D
Desai
Salman
S
Siddiqui
Christopher
C
Brightling
D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones