Monosomy 12 and deletion of 13q34 in a case of chronic lymphocytic leukemia with concomitant lung cancer.
BACKGROUND
We described a patient with chronic lymphocytic leukemia (CLL) and lung cancer and unusual chromosomal aberrations.


METHODS
At the same time with the diagnosis of B-cell CLL, squamocellular lung carcinoma diagnosis was established. Using interphase fluorescence in situ hybridization technique (FISH) we detected monosomy 12 and deletion of 13q34 occurred in the same clone. One month after the beginning of examination the patient died unexpectedly during sleep immediately before we applied a specific treatment for CLL or lung carcinoma.


CONCLUSIONS
Simultaneous occurrence of monosomy 12 and deletion of 13q34 in a patient with B-cell CLL has been described only once before, but as a part of a complex karyotype. The prognostic significance of these abnormalities remains uncertain.
Clinical Center of Serbia, Clinic for Hematology, Belgrade, Serbia. tweety@scnet.rs
Darko
D
Antić
Marija
M
Dencić-Fekete
Dragica
D
Tomin
Irena
I
Djunić
D000368:Aged; D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000235:genetics*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D009006:Monosomy