The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells.
L
L
Bastian
H G
HG
Einsiedel
G
G
Henze
K
K
Seeger
S
S
Shalapour
D045744:Cell Line, Tumor; D002648:Child; D004336:Drug Antagonism; D004357:Drug Synergism; D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
D056572:Histone Deacetylase Inhibitors; D008727:Methotrexate