Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats.
The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC(50)=59.9 µg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Kazuyuki
K
Hiwatashi
Hitoshi
H
Shirakawa
Kazuyuki
K
Hori
Yumiko
Y
Yoshiki
Nao
N
Suzuki
Mika
M
Hokari
Michio
M
Komai
Saori
S
Takahashi
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D051381:Rats; D011918:Rats, Inbred SHR; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry*; D000092502:Renin Inhibitors
D012503:Saponins; D000092502:Renin Inhibitors