Acquired factor V inhibitors: a systematic review.
The occurrence of an inhibitor against coagulation factor V (FV) is a rare but challenging condition, which may span from asymptomatic laboratory abnormalities to potentially life-threatening bleeding. The onset of FV inhibitors has been associated most frequently in the past with the patients' exposure to topical bovine thrombin administered during surgery procedures. However, since this preparation is no longer used, in this systematic review we have only focused on non-bovine thrombin-related FV inhibitor cases.
Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. mfranchini@ao.pr.it
Massimo
M
Franchini
Giuseppe
G
Lippi
D000818:Animals; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D002417:Cattle; D005165:Factor V / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006470:Hemorrhage / Q000097:blood / Q000209:etiology; D006801:Humans
D019774:Blood Coagulation Factor Inhibitors; D005165:Factor V