[Effects of Qiyao Xiaoke capsule on glycolipid metabolism in liver and skeletal muscle of rats with catch-up growth induced by high-fat diet].
OBJECTIVE
To observe the effect of Qiyao Xiaoke Capsule (QXC, a Chinese preparation for invigorating qi and nourishing yin) on glycolipid metabolism in the liver and skeletal muscle of rats with catch-up growth (CUG) induced by high-fat diet.


METHODS
CUG model rats were made by limiting forge followed by high-fat diet, and intervened with different dosages [1.8 (g/kg x d), 0.6 g/(kg x d)] of QXC. And the experiment was controlled with pioglitazone. Levels of blood glucose, serum free fatty acid (FFA), serum insulin (Fins), plasma adiponcetin (AC) and insulin resistance index (IRI) as well as the weights of peri-epididymis and peri-renal fat and their ratio to body weight were observed 8 weeks later. The contents of total cholesterol (TC), triglyceride (TG) and glucose uptake in skeletal muscle and liver were also determined.


RESULTS
Insulin resistance in CUG rats can be induced by high-fat diet. Compared with the un-treated model rats, levels of Fins and AC were higher, IRI and FFA were lower in CUG rats after intervened by QXC (P < 0.05 or P < 0.01). Moreover, QXC at large dose showed the effects of reducing TG content in liver and skeletal muscle, advancing the glucose uptake in skeletal muscle, displaying an efficacy similar to that of pioglitazone (P > 0.05).


CONCLUSIONS
QXC could improve the glycolipid metabolism in high-fat diet-induced CUG rats through different pathways of intervention to alleviate/delay the occurrence and development of insulin resistance in the liver and skeletal muscle.
Shaanxi College of Traditional Chinese Medicine, Shaanxi. zhangxiaoke12340@sina.com
Xiao-Ke
XK
Zhang
Ki-Ping
KP
Han
Li
L
Ma
D000818:Animals; D002446:Celiac Disease; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D005947:Glucose