Homogenous asymmetric hydrogenation: Recent trends and industrial applications.
Recent advances in the field of homogeneous asymmetric hydrogenation are presented in this review. An analysis of academic literature published in the past 2 years highlights significant advances in the asymmetric hydrogenation of functional groups that previously were considered difficult to hydrogenate, as well as the emergence of novel concepts in catalysis, such as the use of non-traditional metals, phosphine-free catalysts and chiral counterions. An analysis of industry publications from 2009 and 2010 highlights more established applications of asymmetric hydrogenation reactions; these are discussed with a particular focus on practical aspects, such as catalyst selection, experimental conditions and the removal of metal residues.
Nycomed GmbH, Department of Medicinal Chemistry, Byk-Gulden-Strasse 2, D-78467 Konstanz, Germany. andreas.palmer@nycomed.com
Andreas M
AM
Palmer
Antonio
A
Zanotti-Gerosa
D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends*; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism