Early motor balance and coordination training increased synaptophysin in subcortical regions of the ischemic rat brain.
The aim of this study was to evaluate the effect of early motor balance and coordination training on functional recovery and brain plasticity in an ischemic rat stroke model, compared with simple locomotor exercise. Adult male Sprague-Dawley rats with cortical infarcts were trained under one of four conditions: nontrained control, treadmill training, motor training on the Rota-rod, or both Rota-rod and treadmill training. All types of training were performed from post-operation day 1 to 14. Neurological and behavioral performance was evaluated by Menzies' scale, the prehensile test, and the limb placement test, at post-operation day 1, 7, and 14. Both Rota-rod and treadmill training increased the expression of synaptophysin in subcortical regions of the ischemic hemisphere including the hippocampus, dentate gyrus, and thalamus, but did not affect levels of brain-derived neurotrophic factor or tyrosin kinase receptor B. The Rota-rod training also improved Menzies' scale and limb placement test scores, whereas the simple treadmill training did neither. The control group showed significant change only in Menzies' scale score. This study suggests that early motor balance and coordination training may induce plastic changes in subcortical regions of the ischemic hemisphere after stroke accompanied with the recovery of sensorimotor performance.
Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Korea.
Han Gil
HG
Seo
Dae-Yul
DY
Kim
Hee Won
HW
Park
Shi-Uk
SU
Lee
Sung-Hye
SH
Park
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009043:Motor Activity; D009473:Neuronal Plasticity / Q000502:physiology; D010805:Physical Conditioning, Animal; D026741:Physical Therapy Modalities; D051381:Rats; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism; D020521:Stroke / Q000378:metabolism* / Q000503:physiopathology; D016708:Synaptophysin / Q000378:metabolism*; D013788:Thalamus / Q000378:metabolism; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor; D016708:Synaptophysin; D020813:Receptor, trkB