Copper complex of a pyridine-modified poly(amidoamine) dendrimer as a chemical nuclease: synthetic and catalytic study.
[Cu(Y)((G:2-6)-dendri-PAMAM-(Py)(n))](2Y+) complexes (3) were prepared, and their ability to generate oxygen radical anions was investigated. The maximum catalytic efficiency (k'(cat)/K(M)) was found to be 0.32 min(-1)·μM(-1), and a positive dendritic effect was observed. The saturated kinetics revealed that the improved catalytic efficiency resulted from an enhanced binding affinity toward molecular oxygen.


BACKGROUND
In this basic science study, the oxygen radical anion generating ability of specific copper complex of a pyridine-modified poly(amidoamine) dendrimer was investigated and reported in details.
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan. clkao@kmu.edu.tw
Chai-Lin
CL
Kao
Yi-Hsuan
YH
Tang
Yen Chung
YC
Lin
Li-Ting
LT
Chiu
Hui-Ting
HT
Chen
Sodio C N
SC
Hsu
Kuang-Chan
KC
Hsieh
Chi-Yu
CY
Lu
Yeh-Long
YL
Chen
D000838:Anions; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D003851:Deoxyribonucleases / Q000378:metabolism*; D007700:Kinetics; D010100:Oxygen / Q000737:chemistry; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000838:Anions; D050091:Dendrimers; C531249:Poly(amidoamine); D011073:Polyamines; D011725:Pyridines; D003300:Copper; D003851:Deoxyribonucleases; C023666:pyridine; D010100:Oxygen