Photochemical cleavage of leader peptides.
We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyne-azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S Mathews Ave, Urbana, IL 61801, USA.
Noah
N
Bindman
Remco
R
Merkx
Robert
R
Koehler
Nicholas
N
Herrman
Wilfred A
WA
van der Donk
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001430:Bacteriocins / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D010782:Photolysis; D021382:Protein Sorting Signals; D014466:Ultraviolet Rays
D000480:Alkynes; D001386:Azides; D001430:Bacteriocins; D021382:Protein Sorting Signals; C082508:lacticin 481; D003300:Copper