Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base.
A detailed study on the reaction mechanism of trans-EE and trans-EE/Met Pt-containing anticancer drugs was carried out in order to rationalize the experimental kinetic data concerning the whole process leading to DNA platination.
Dipartimento di Chimica, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy.
Marta E
ME
Alberto
Nino
N
Russo
D000970:Antineoplastic Agents / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D008024:Ligands; D008715:Methionine / Q000737:chemistry*; D017671:Platinum Compounds / Q000494:pharmacology*
D000970:Antineoplastic Agents; D008024:Ligands; D017671:Platinum Compounds; D006147:Guanine; D004247:DNA; D008715:Methionine