The Clinical Importance of the Heterogeneity of HER2 neu.
We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend retesting a large portion of the tumor in all cases of initially negative test results.
Aventura Comprehensive Cancer Center, Aventura, Fla., USA.
Enrique
E
Davila
Kip
K
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