TGF-β1 869T/C polymorphism and ischemic stroke: sex difference in Chinese.
BACKGROUND
Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cerebrovascular complications. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine with a central role in inflammation. To investigate whether polymorphisms of the TGF-β1 gene can modify the risk of ischemic stroke (IS) in Chinese population, we conduct this hospital-based, case-control study.


METHODS
Transforming growth factor-β1 genotype was determined in 450 Chinese patients (306 male and 144 female) with IS and 450 control subjects (326 male and 124 female).


RESULTS
Subjects carrying 869TT were susceptible to IS (odds ratio [OR] =1.58; P=0.003). Further analysis of IS data partitioned by gender revealed the female-specific association with 869T/C (OR=2.64; P=0.001).


CONCLUSIONS
Findings suggest that the TT genotype of 869T/C might be a risk factor of IS in Chinese, especially in females.
School of Medicine, Jinhua College of Profession & Technology, Jinhua, Zhejiang Province, the People's Republic of China.
Hong-Miao
HM
Tao
Guo-Zhong
GZ
Chen
Xiao-Dong
XD
Lu
Gan-Ping
GP
Chen
Bei
B
Shao
D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012727:Sex Characteristics; D018709:Statistics, Nonparametric; D020521:Stroke / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D053773:Transforming Growth Factor beta1