Glutamate microinjection at the medial preoptic area enhances slow wave sleep in rats.
A large body of evidence has established the role of the medial preoptic area (mPOA) in regulation of slow wave sleep (SWS). Although the mPOA neurons contain excitatory neurotransmitter glutamate, its role in sleep-wakefulness is not known. In the present study microinjection of monosodium glutamate (40, 80 and 120 ng) into the mPOA augmented SWS. Earlier reports have shown enhancement of paradoxical sleep by glutamate in other brain areas.
Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Mahesh K
MK
Kaushik
Velayudhan Mohan
VM
Kumar
Hruda Nanda
HN
Mallick
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D012970:Sodium Glutamate