Novel insights into molecular mechanisms of abruption-induced preterm birth.
Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption.
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA. catalin.buhimschi@yale.edu
Catalin S
CS
Buhimschi
Frederik
F
Schatz
Graciela
G
Krikun
Irina A
IA
Buhimschi
Charles J
CJ
Lockwood
D000037:Abruptio Placentae; D005260:Female; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology*; D015398:Signal Transduction