Drug induced mania in a boy with high functioning autism.
Drug induced mania is sometimes associated with drug that are primarily not used for central nervous system effects. Here we report a manic episode during the treatment of leukemia with various agents in an adolescent with diagnosis of high functioning autism. In this case, most likely candidates to induce a manic episode were dexamethazone, a corticosteroid used in the treatment of T-ALL, cyclophosphamide and cotrimoxazole. Although literature on mood disorders associated with corticosteroids exceeds that of cyclophosphamide and cotrimoxazole, an absolute causal drug cannot be stated.
Child, and Adolescent Psychiatry Department, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Mustafa Deniz
MD
Tutkunkardas
Nahit Motavalli
NM
Mukaddes
D000293:Adolescent; D000339:Affect / Q000187:drug effects; D018692:Antimanic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D001321:Autistic Disorder / Q000150:complications* / Q000523:psychology; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D008297:Male; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D018692:Antimanic Agents