Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes.
It has been long debated whether spliceosomal introns originated in the common ancestor of eukaryotes and prokaryotes. In this study, we tested the possibility that extant introns were inherited from the common ancestor of eukaryotes and prokaryotes using in silico simulation. We first identified 21 intron positions that are shared among different families of the P-Type ATPase superfamily, some of which are known to have diverged before the separation of prokaryotes and eukaryotes. Theoretical estimates of the expected number of intron positions shared by different genes suggest that the introns at those 21 positions were inserted independently. There seems to be no intron that arose from before the diversification of the P-Type ATPase superfamily. Namely, the present introns were inserted after the separation of eukaryotes and prokaryotes.
Laboratory of Plasma Membrane and Nuclear Signaling, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan. toda.m08@lif.kyoto-u.ac.jp
Toshiyuki
T
Oda
Ryosuke L
RL
Ohniwa
Yuki
Y
Suzuki
Masatsugu
M
Denawa
Masahiro
M
Kumeta
Hideyuki
H
Okamura
Kunio
K
Takeyasu
D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D040461:Gene Components; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D006180:Proton-Translocating ATPases / Q000235:genetics*; D016415:Sequence Alignment; D013045:Species Specificity; D017381:Spliceosomes / Q000235:genetics*
D006180:Proton-Translocating ATPases