Building addressable libraries: site-selective use of Pd(0) catalysts on microelectrode arrays.
Site-selective Pd(0)-catalyzed reactions have been developed to functionalize a microelectrode array. Heck, Suzuki, and allylation reactions have all been accomplished. The reactions are compatible with both 1K and 12K arrays and work best when a nonsugar porous reaction layer is used. Suzuki reactions are faster than the Heck reactions and thus require more careful control of the reactions in order to maintain confinement. The allylation reaction requires a different confining agent than the Heck and Suzuki reactions but can be accomplished nicely with quinone as an oxidant for Pd(0).
Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
Libo
L
Hu
Melissae
M
Stuart
Jun
J
Tian
Karl
K
Maurer
Kevin D
KD
Moeller
D002384:Catalysis; D046228:Microarray Analysis; D008839:Microelectrodes; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
D010455:Peptides; D010165:Palladium