The effectiveness of ethanolic extract of Amaranthus tricolor L.: A natural hepatoprotective agent.
The ethanolic extract of Amaranthus tricolor L. (ATE) leaves was tested for its efficacy against CCl₄-induced liver toxicity in rats. The hepatoprotective activity of ATE was evaluated via measuring various liver toxicity parameters, the lipid profile, and a histopathological evaluation. A sleeping time determination study and an acute toxicity test were performed in mice. The results clearly showed that oral administration of ATE for three weeks significantly reduced the elevated levels of serum GOT, GPT, GGT, ALP, bilirubin, cholesterol, LDL, VLDL, TG, and MDA induced by CCl₄. Moreover, ATE treatment was also found to significantly increase the activities of NP-SH and TP in liver tissue. These biochemical findings have been supported by the evaluation of the liver histopathology in rats. The prolongation of narcolepsy induced by pentobarbital was shortened significantly by the extract. The acute toxicity test showed that no morbidity or mortality was caused by the extract. The observed hepatoprotective effect appears to be due to the antioxidant properties of A. tricolor, which may pave the way to finding a new drug to be used for fighting liver diseases.
Department of Pharmacognosy, King Saud University, Riyadh, Saudi Arabia. msdosari@yahoo.com
Mohammed S
MS
Al-Dosari
D027721:Amaranthus / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001663:Bilirubin / Q000097:blood; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D009290:Narcolepsy / Q000188:drug therapy* / Q000209:etiology; D010424:Pentobarbital; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D011506:Proteins; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D010424:Pentobarbital; D001663:Bilirubin