[Colorectal serrated lesions: current insight on their role in colorectal carcinogenesis].
The classification of colorectal cancer precursor lesions has become more accurate after the discovery of serrated polyps. These are characterized by saw-tooth-like epithelial growth pattern, and are the most significant group of colorectal cancer precursors after conventional adenomas. While conventional adenomas are characterized by tumour suppressor gene mutations and chromosomal instability, serrated adenomas harbour KRAS/BRAF mutations, inhibition of apoptosis, DNA hypermethylation, and microsatellite instability. These alterations occur in about 20% of colorectal cancers, and along with preserved serrated morphology suggest their origin in serrated polyps. The recognition of serrated polyps as colorectal cancer precursors is crucial for their follow-up.
Oulun yliopisto, diagnostiikan laitos PL 5000, 90014 Oulun yliopisto.
Markus
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Mäkinen
D000236:Adenoma / Q000235:genetics / Q000473:pathology*; D017209:Apoptosis; D003111:Colonic Polyps / Q000235:genetics / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology*; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053842:Microsatellite Instability; D009154:Mutation; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics
D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras)