Drug release mechanisms of compressed lipid implants.
The aim of this study was to elucidate the mass transport mechanisms controlling drug release from compressed lipid implants. The latter steadily gain in importance as parenteral controlled release dosage forms, especially for acid-labile drugs. A variety of lipid powders were blended with theophylline and propranolol hydrochloride as sparingly and freely water-soluble model drugs. Cylindrical implants were prepared by direct compression and thoroughly characterized before and after exposure to phosphate buffer pH 7.4. Based on the experimental results, an appropriate mathematical theory was identified in order to quantitatively describe the resulting drug release patterns. Importantly, broad release spectra and release periods ranging from 1 d to several weeks could easily be achieved by varying the type of lipid, irrespective of the type of drug. Interestingly, diffusion with constant diffusivities was found to be the dominant mass transport mechanism, if the amount of water within the implant was sufficient to dissolve all of the drug. In these cases an analytical solution of Fick's second law could successfully describe the experimentally measured theophylline and propranolol hydrochloride release profiles, even if varying formulation and processing parameters, e.g. the type of lipid, initial drug loading, drug particles size as well as compression force and time. However, based on the available data it was not possible to distinguish between drug diffusion control and water diffusion control. The obtained new knowledge can nevertheless significantly help facilitating the optimization of this type of advanced drug delivery systems, in particular if long release periods are targeted, which require time consuming experimental trials.
University Lille Nord de France, College of Pharmacy, 3 Rue du Prof Laguesse, 59006 Lille, France.
F
F
Kreye
F
F
Siepmann
J
J
Siepmann
D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D004343:Drug Implants; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D010316:Particle Size; D011208:Powders; D011433:Propranolol / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013806:Theophylline / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D004337:Drug Carriers; D004343:Drug Implants; D008055:Lipids; D011208:Powders; D014867:Water; D011433:Propranolol; D013806:Theophylline