Side effects and management of side effects of methotrexate in rheumatoid arthritis.
Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ-specific side effects and outlines the current recommendations addressing prevention and management of MTX-associated adverse effects.
Kerckhoff Clinic Bad Nauheim, Department of Rheumatology and Immunology, University of Giessen, Germany. katinkaalbrecht@yahoo.de
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K
Albrecht
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Müller-Ladner
D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D008727:Methotrexate