Design and synthesis of phthalimide-based fluorescent liver x receptor antagonists.
Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.
Okayama University, Japan.
Kenji
K
Kishida
Atsushi
A
Aoyama
Yuichi
Y
Hashimoto
Hiroyuki
H
Miyachi
D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D000071518:Liver X Receptors; D015394:Molecular Structure; D057093:Orphan Nuclear Receptors / Q000037:antagonists & inhibitors*; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D005456:Fluorescent Dyes; D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010797:Phthalimides