Palladium-catalyzed benzylic arylation of 2-methyl azaarenes.
A palladium-catalyzed benzylic sp(3) direct arylation of electron-deficient heterocycles is reported. The method described enables the introduction of electron-rich and -poor aromatics at the benzylic position of heterocycles without the need for preactivation or the use of directing groups.
Syngenta Ltd., Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
Paul M
PM
Burton
James A
JA
Morris
D001372:Aza Compounds / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D008745:Methylation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D001372:Aza Compounds; D008024:Ligands; D010165:Palladium; D001554:Benzene