Mesh covered stent in ST-segment elevation myocardial infarction.
OBJECTIVE
The MGuard stent (bare metal stent wrapped externally with a polymer mesh sleeve) is designed to prevent distal embolisation by reducing thrombus and plaque fragments released during and post percutaneous coronary intervention (PCI). The aim of this study was to confirm the clinical feasibility, safety and performance of the MGuard stent during primary PCI for ST-segment elevation myocardial infarction (STEMI).


RESULTS
The present study was a multicentre, prospective, single arm study in which 60 patients with STEMI <12 hours were enrolled. Predilatation was performed in 61.7% of the cases and thrombus aspiration in 18.3%. In one (1.7%) patient the stent could not cross the lesion. Final TIMI grade 3 flow was observed in 90.0% of patients, with myocardial blush grade 3 in 73.3% of patients and complete (>70%) ST-segment resolution 60 minutes after PCI in 61.4% of patients. In 5.0% of cases distal embolisation occurred. The total major adverse cardiac events rate during the 6-month follow-up was 1.7%.


CONCLUSIONS
Based on this experience, the MGuard stent implantation in STEMI patients is safe and highly effective. A larger randomised trial is warranted to confirm the clinical endpoints.
Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland. mcdudek@cyf-kr.edu.pl
Dariusz
D
Dudek
Artur
A
Dziewierz
Łukasz
Ł
Rzeszutko
Jacek
J
Legutko
Wojciech
W
Dobrowolski
Tomasz
T
Rakowski
Stanisław
S
Bartus
Jacek
J
Dragan
Artur
A
Klecha
Alexandra-J
AJ
Lansky
Zbigniew
Z
Siudak
Krzysztof
K
Zmudka
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D011474:Prosthesis Design; D015607:Stents