Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents.
Three-component coupling of aldehyde, indole and kojic acid has been achieved using a catalytic amount of InCl(3) under solvent free conditions to produce a novel series of 2-substituted aryl(indolyl)kojic acid derivatives in good yields and with high selectivity. These compounds are found to exhibit potent antifungal properties.
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India. basireddy@iict.res.in
B V Subba
BV
Reddy
M Ramana
MR
Reddy
Ch
Ch
Madan
K Pranay
KP
Kumar
M Srinivasa
MS
Rao
D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D011753:Pyrones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007211:Indoles; D011753:Pyrones; D007204:Indium; C020758:indium trichloride; C011890:kojic acid; C030374:indole