Flavonoids from Halostachys caspica and their antimicrobial and antioxidant activities.
Seven flavonoids have been isolated from the aerial parts of Halostachys caspica C. A. Mey. (Chenopodiaceae) for the first time. By means of physicochemical and spectrometric analysis, they were identified as luteolin (1), chrysin (2), chrysin 7-O-β-D-glucopyranoside (3), quercetin (4), quercetin 3-O-β-D-glucopyranoside (5), isorhamentin-3-O-β-D-glucopyranoside (6), and isorhamentin-3-O-β-D-rutinoside (7). All flavonoids were evaluated to show a broad antimicrobial spectrum of activity on microorganisms including seven bacterial and one fungal species as well as pronounced antioxidant activity. Among them, the aglycones with relatively low polarity had stronger bioactivity than their glycosides. The results suggested that the isolated flavonoids could be used for future development of antimicrobial and antioxidant agents, and also provided additional data for supporting the use of H. caspica as forage.
College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.
Hao
H
Liu
Yan
Y
Mou
Jianglin
J
Zhao
Jihua
J
Wang
Ligang
L
Zhou
Mingan
M
Wang
Daoquan
D
Wang
Jianguo
J
Han
Zhu
Z
Yu
Fuyu
F
Yang
D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay; D001713:Biphenyl Compounds / Q000737:chemistry; D019663:Chenopodiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology; D047311:Luteolin / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010851:Picrates / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology
D000890:Anti-Infective Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D044948:Flavonols; D005960:Glucosides; D010851:Picrates; C043561:chrysin; D011794:Quercetin; C432511:isorhamnetin 3-O-glucoside; C004931:1,1-diphenyl-2-picrylhydrazyl; D047311:Luteolin; C110309:quercetin 3-O-glucopyranoside