Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study.
Dopamine (DA) and serotonin (5-HT) transporter availability in heroin users and healthy controls was measured using [¹²³I]β-CIT and SPECT imaging. Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found.
Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States. kelly.cosgrove@yale.edu
Kelly P
KP
Cosgrove
Karen
K
Tellez-Jacques
Brian
B
Pittman
Ismene
I
Petrakis
Ronald M
RM
Baldwin
Gilles
G
Tamagnan
John
J
Seibyl
Thomas
T
Kosten
Julie K
JK
Staley
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D001931:Brain Mapping; D002908:Chronic Disease; D003042:Cocaine / Q000031:analogs & derivatives; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006556:Heroin Dependence / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult
D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine; D004298:Dopamine