Does this patient have malaria?
BACKGROUND
Malaria commonly infects residents of and travelers to tropical regions. The clinical features of infection are notoriously nonspecific but have not been comprehensively evaluated.


OBJECTIVE
To systematically review and synthesize data related to the predictive value of clinical findings for the diagnosis of malaria in endemic areas and in travelers returning from endemic areas.


METHODS
The databases of MEDLINE and EMBASE (1950-July 2010) were searched to identify studies published in the English language of endemic and "imported" (acquired during travel) malaria. Additional studies were identified from reference lists. Studies were included that had patients suspected of having acute malaria (usually because of fever) and compared the presence or absence of clinical findings with blood smear confirmation. Two authors independently identified studies, appraised study quality, and extracted data on the patient population, outcome assessment, and clinical findings. Differences between reviewers were resolved by consensus.


RESULTS
Fourteen studies for endemic malaria were identified that met review criteria. Individual symptoms are of limited diagnostic utility but presence of splenomegaly (summary likelihood ratio [LR], 3.3; 95% confidence interval [CI], 2.0-4.7) or hepatomegaly (summary LR, 2.4; 95% CI, 1.6-3.6) make malaria more likely. Combinations of findings can affect the likelihood of malaria, but their performance varies by setting. Seven studies of imported malaria were identified. The presence of fever (LR, 5.1; 95% CI, 4.9-5.3), splenomegaly (summary LR, 6.5; 95% CI, 3.9-11.0), hyperbilirubinemia (LR, 7.3; 95% CI, 5.5-9.6), or thrombocytopenia (summary LR, 5.6; 95% CI, 4.1-7.5) make malaria more likely.


CONCLUSIONS
In endemic areas, the likelihood of malaria is increased by the presence of splenomegaly and hepatomegaly but individual findings are of limited utility and cannot reliably exclude malaria; combinations of findings may be useful to stratify risk in patients. In returning travelers, the clinical assessment can provide substantial diagnostic benefit, although all patients still require laboratory testing because malaria can be rapidly fatal.
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA. taylo115@email.unc.edu
Steve M
SM
Taylor
Malcolm E
ME
Molyneux
David L
DL
Simel
Steven R
SR
Meshnick
Jonathan J
JJ
Juliano
D000328:Adult; D002675:Child, Preschool; D019353:Endemic Diseases; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D008288:Malaria / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D011237:Predictive Value of Tests; D013163:Splenomegaly / Q000209:etiology; D014195:Travel