Rab25 as a tumour suppressor in colon carcinogenesis.
Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpression is associated with ovarian cancer aggressive behaviour, Rab25 expression is decreased in human colon cancers independent of stage. Recent studies of mouse models of intestinal and colonic neoplasia have demonstrated that Rab25 deficiency markedly promotes the development of neoplasia. Some of these effects appear related to alterations in β1-integrin trafficking to the cell surface. These findings all suggest that Rab25 is a tumour suppressor for colonic neoplasia.
Nashville VA Medical Center and the Department of Surgery, Epithelial Biology Center, Vanderbilt University School of Medicine, 10435G MRBIV, 2213 Garland Avenue, Nashville, TN 37232-2733, USA. jim.goldenring@vanderbilt.edu
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D000818:Animals; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051379:Mice; D011506:Proteins / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D020691:rab GTP-Binding Proteins / Q000502:physiology*
C426009:LAMTOR2 protein, mouse; D011506:Proteins; C509763:Rab25 protein, human; D025521:Tumor Suppressor Proteins; D020691:rab GTP-Binding Proteins