ConsensusPathDB: toward a more complete picture of cell biology.
ConsensusPathDB is a meta-database that integrates different types of functional interactions from heterogeneous interaction data resources. Physical protein interactions, metabolic and signaling reactions and gene regulatory interactions are integrated in a seamless functional association network that simultaneously describes multiple functional aspects of genes, proteins, complexes, metabolites, etc. With 155,432 human, 194,480 yeast and 13,648 mouse complex functional interactions (originating from 18 databases on human and eight databases on yeast and mouse interactions each), ConsensusPathDB currently constitutes the most comprehensive publicly available interaction repository for these species. The Web interface at http://cpdb.molgen.mpg.de offers different ways of utilizing these integrated interaction data, in particular with tools for visualization, analysis and interpretation of high-throughput expression data in the light of functional interactions and biological pathways.
Vertebrate Genomics Department, Max Planck Institute for Molecular Genetics, Ihnestr 63-73, 14195 Berlin, Germany. kamburov@molgen.mpg.de
Atanas
A
Kamburov
Konstantin
K
Pentchev
Hanna
H
Galicka
Christoph
C
Wierling
Hans
H
Lehrach
Ralf
R
Herwig
D000818:Animals; D016208:Databases, Factual; D030541:Databases, Genetic; D015870:Gene Expression; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D053858:Metabolic Networks and Pathways; D051379:Mice; D025941:Protein Interaction Mapping; D015398:Signal Transduction; D014584:User-Computer Interface