Production of large quantities of 90Y by ion-exchange chromatography using an organic resin and a chelating agent.
The performance of a system composed of an organic cation exchanger (Dowex 50Wx8) and a chelating agent (EDTA) previously described for the successful production of (90)Y via a (90)Sr/(90)Y generator is assessed under dynamic conditions. In an attempt to overcome the established limitation of ion-exchange resins for the separation of subcurie quantities of activity, (90)Y is repeatedly isolated from an 11.8-GBq (320 mCi) (90)Sr cow using a three-column tandem arrangement. The high recovery and radionuclidic purity obtained for (90)Y and the parameters of the separation (time, eluant concentration, pH and flow rate range) strongly suggest that Ci quantities of (90)Y can be handled satisfactorily by the ion-exchange method. No replacement or treatment of the cow, low waste generation and (90)Sr losses less than 0.1% after each run were observed during the present study which, in combination with the low cost of this resin, may result in an attractive alternate method for the production of large quantities of (90)Y.
Centro de Isótopos (CENTIS), Ave. Monumental y Carretera La Rada Km 3 1/2, Guanabacoa, Havana, Cuba. axcastillo@yahoo.com
Abmel Xiques
AX
Castillo
Marylaine
M
Pérez-Malo
Keila
K
Isaac-Olivé
Heyam
H
Mukhallalati
Edgar Casanova
EC
González
Mirta Torres
MT
Berdeguez
Néstor Cornejo
NC
Díaz
D002614:Chelating Agents / Q000737:chemistry*; D002852:Chromatography, Ion Exchange / Q000379:methods*; D004492:Edetic Acid / Q000737:chemistry; D007475:Ion Exchange Resins / Q000737:chemistry*; D013326:Strontium Radioisotopes / Q000737:chemistry / Q000302:isolation & purification; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000737:chemistry / Q000302:isolation & purification
D002614:Chelating Agents; D007475:Ion Exchange Resins; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes; D004492:Edetic Acid