Lycopodium alkaloids from Huperzia serrata.
A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC(50) value of 0.92 μM.
Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yan-Fang
YF
Yang
Shi-Jin
SJ
Qu
Kai
K
Xiao
Shan-Hao
SH
Jiang
Jun-Jie
JJ
Tan
Chang-Heng
CH
Tan
Da-Yuan
DY
Zhu
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032501:Huperzia / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013570:Synaptic Membranes / Q000187:drug effects
C554074:12-deoxyhuperzine O; C554073:6-hydroxy-5,15-oxide-lycopodane; D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D016194:Receptors, N-Methyl-D-Aspartate