Epigenetic control of stem cell fate to neurons and glia.
How a cell fate is determined and how tremendously diverse cells are generated during development are interesting and intriguing questions to be solved before using the stem cells for therapeutic purpose. Recently, it has been suggested that epigenetic control by the histone modifying enzymes and non-coding RNAs play important roles in guiding stem cells to differentiate into neurons or glia. In this review, we discuss the recent outcomes and advances in understanding the histone modifying enzymes and non-coding RNAs during neural cell-type specification of stem cells.
Laboratory of Molecular and Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, Korea. hyunjungkim@cau.ac.kr
Hyun-Jung
HJ
Kim
Michael G
MG
Rosenfeld
D000107:Acetylation; D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D035683:MicroRNAs / Q000502:physiology; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism*; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology*
D006657:Histones; D035683:MicroRNAs