Pathways and promoter networks analysis provides systems topology for systems biology approaches.
Systems-level approaches provide help in characterizing the complexity of renal disease. In this review, we illustrate, using a series of recent examples of integrative studies based on pathway analysis and promoter networks, how new techniques allow the analysis of the layout of complex systems and, through this, help answer questions related to renal disease processes. These technologies include the identification of regulatory pathways dysregulated in the context of renal disease, and techniques for studying promoter networks. Both approaches make use of technologies applied to large-scale transcriptomics, transcriptomic profiling by DNA microarrays, or next-generation sequencing.
Medical Policlinic, Ludwig-Maximilians-University of Munich, Munich, Germany. peter.nelson@med.uni-muenchen.de
Peter J
PJ
Nelson
Thomas
T
Werner
D000818:Animals; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006706:Homeostasis; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D049490:Systems Biology / Q000379:methods*