The involvement of protein phosphatases in platelet activation.
Protein phosphatase (PP) activities have long been known in platelets, but their physiological roles in platelet reactions are not well understood. Since the discovery of the okadaic acid (OA) class of compounds, potent and cell-permeable PP 1/2A inhibitors, evidence for the active involvement of PP1/2A in platelet reactions has rapidly accumulated. This article reviews the possible involvement of PP1/2A in platelet function by focusing on the effects of OA class compounds on agonist-induced platelet reactions.
Department of Surgery II, Osaka University Medical School, 2-2, Yamadaoka, Suita, Osaka, 565, Japan, 81 6-879-3257, 81-6-879-3259.
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M
Sakon
J I
JI
Kambayashi
K H
KH
Murata