Synthetic mRNAs: powerful tools for reprogramming and differentiation of human cells.
In this issue of Cell Stem Cell, Warren et al. (2010) describe a new methodology, using synthetic mRNA, for efficiently generating iPSCs without compromising genomic integrity. This powerful approach can also be used for directed differentiation of iPSCs, or even for trans-differentiation to generate clinically relevant differentiated cell types.
Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY 10065, USA.
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