[Significance of H. pylori eradication in treatment and prevention for low-dose aspirin induced gastric ulcer of elderly].
Although treatment and prevention for low-dose aspirin (LDA) induced gastrointestinal mucosal injury is important problem, significance of H. pylori eradication has not been clarified. NSAIDs including LDA and H. pylori infection are independent causal factors for gastroduodenal ulcer. However, the interaction between these factors is complicated. H. pylori eradication can reduce the risk of NSAIDs induced ulcer in NSAIDs naive patients. However, H. pylori eradication is not recommended in NSAIDs user because of no ulcer suppression and ulcer healing delay. In prevention of LDA induced ulcer recurrence, H. pylori eradication plus PPI treatment are necessary.
Division of Endoscopy, Hokkaido University Hospital.
Mototsugu
M
Kato
Shouko
S
Ono
Takeshi
T
Yoshida
Katsuhiro
K
Mabe
Yuichi
Y
Shimizu
Masahiro
M
Asaka
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000382:microbiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin