Serology of celiac disease in gluten-sensitive ataxia or neuropathy: role of deamidated gliadin antibody.
The role and relevance of deamidated gliadin antibodies specific for celiac disease in gluten-sensitive ataxia/neuropathy is unknown. We investigated the association of celiac-specific serology with gluten-sensitive ataxia/neuropathy, in patients with and without gliadin-induced enteropathy. 51 patients with unexplained ataxia/neuropathy suspected to have gluten sensitivity were included in the study and their serum celiac-specific markers were measured. Deamidated gliadin-IgA (83% vs. 22%), deamidated gliadin-IgG (50% vs. 3%), tissue transglutaminase-IgA (78% vs. 11%), and anti-endomysial-IgA (70% vs. 0%), were significantly more positive in ataxia/neuropathy patients with celiac disease versus those without enteropathy (P<0.001). Our findings suggest that the serological profile of gluten-sensitive ataxia/neuropathy without intestinal involvement lacks the recognition of deamidated gliadin and tissue transglutaminase epitopes.
Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street, SW Rochester, MN 55905, USA.
Shahrooz
S
Rashtak
Shadi
S
Rashtak
Melissa R
MR
Snyder
Sean J
SJ
Pittock
Tsung-Teh
TT
Wu
Manish J
MJ
Gandhi
Joseph A
JA
Murray
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000097:blood / Q000276:immunology; D002446:Celiac Disease / Q000097:blood* / Q000276:immunology / Q000473:pathology; D002524:Cerebellar Ataxia / Q000097:blood / Q000276:immunology*; D003641:Deamination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D005903:Gliadin / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000276:immunology*; D011503:Transglutaminases / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases