Antiphospholipid syndrome; its implication in cardiovascular diseases: a review.
Antiphospholipid syndrome (APLS) is a rare syndrome mainly characterized by several hyper-coagulable complications and therefore, implicated in the operated cardiac surgery patient. APLS comprises clinical features such as arterial or venous thromboses, valve disease, coronary artery disease, intracardiac thrombus formation, pulmonary hypertension and dilated cardiomyopathy. The most commonly affected valve is the mitral, followed by the aortic and tricuspid valve. For APLS diagnosis essential is the detection of so-called antiphospholipid antibodies (aPL) as anticardiolipin antibodies (aCL) or lupus anticoagulant (LA). Minor alterations in the anticoagulation, infection, and surgical stress may trigger widespread thrombosis. The incidence of thrombosis is highest during the following perioperative periods: preoperatively during the withdrawal of warfarin, postoperatively during the period of hypercoagulability despite warfarin or heparin therapy, or postoperatively before adequate anticoagulation achievement. Cardiac valvular pathology includes irregular thickening of the valve leaflets due to deposition of immune complexes that may lead to vegetations and valve dysfunction; a significant risk factor for stroke. Patients with APLS are at increased risk for thrombosis and adequate anticoagulation is of vital importance during cardiopulmonary bypass (CPB). A successful outcome requires multidisciplinary management in order to prevent thrombotic or bleeding complications and to manage perioperative anticoagulation. More work and reporting on anticoagulation management and adjuvant therapy in patients with APLS during extracorporeal circulation are necessary.
Cardiothoracic Surgery Department, University of Patras, School of Medicine, Patras, Greece. iokoniari@yahoo.gr
Ioanna
I
Koniari
Stavros N
SN
Siminelakis
Nikolaos G
NG
Baikoussis
Georgios
G
Papadopoulos
John
J
Goudevenos
Efstratios
E
Apostolakis
D054058:Acute Coronary Syndrome / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D017152:Antibodies, Antiphospholipid / Q000502:physiology; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D006348:Cardiac Surgical Procedures; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D023903:Coronary Restenosis; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy
D017152:Antibodies, Antiphospholipid