Trichinella spiralis: infection reduces airway allergic inflammation in mice.
In an effort to define the mechanism underlying the host immune downregulation inherent to Trichinella spiralis infection, we compared the levels of Th1, Th2, and regulatory cytokines and CD4(+)CD25(+) forkhead box P3 (FoxP3)(+) T (T(reg)) cell recruitment, as well as cellular pathology in the airway between T. spiralis infected and uninfected asthma-induced mice. After the induction of allergic airway inflammation, we noted influxes of inflammatory cells into the peribronchial tree. However, in the T. spiralis infection groups, cellular infiltration was minimal around the bronchial tree, with only a smattering of inflammatory cells. In the OVA-challenged group after T. spiralis infection, the numbers of macrophages and eosinophils in the bronchial alveolar lavage fluid were reduced by 23% and 52%, respectively, as compared to those of the OVA-challenged group. Airway hyperresponsiveness of OVA-challenged mice after T. spiralis infection was significantly suppressed as compared to the OVA-only challenged mice. The T. spiralis-infected mice exhibited a significant reduction in IL-5 concentrations relative to that noted in the OVA-challenged group (p<0.01). Nevertheless, the regulatory cytokines IL-10 and TGF-β levels were increased significantly as the result of T. spiralis infection, and we verified the recruitment of T(reg) cells in lung draining lymph nodes via T. spiralis infection. Therefore, T(reg) cells, which were recruited by T. spiralis infection, might ameliorate lung function and reduce allergic airway inflammation.
Department of Internal Medicine, School of Medicine, Pusan National University, 626-870 Busan, Republic of Korea.
Hye-Kyung
HK
Park
Min Kyoung
MK
Cho
Seon Hee
SH
Choi
Yun Seong
YS
Kim
Hak Sun
HS
Yu
D000818:Animals; D001249:Asthma / Q000150:complications / Q000276:immunology* / Q000517:prevention & control; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007136:Immunoglobulins / Q000097:blood; D007249:Inflammation / Q000276:immunology / Q000517:prevention & control; D008168:Lung; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D012137:Respiratory System / Q000473:pathology; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000150:complications* / Q000276:immunology
D016207:Cytokines; D007136:Immunoglobulins