[The activation of specific immunity in male mice stimulates fertility of their breeding partners: the phenomenon of lot's daughters].
In previous experimental studies on laboratory mice, it was shown that activation of specific immunity by injection with sheep red blood cells (SRBC) lessens males' sexual olfactory attractiveness for intact females. However, reduced attractiveness can decrease males' reproductive efficiency only under the conditions of free mating, which is not obligatory for natural populations. The goal of this work was to study the influence of immunoenhancement on sexual behavior and reproductive output of outbred ICR male mice. Males, either injected with saline (control group) or SRBC-treated, were kept with intact females during 5 days after injection. While the number of fertile copulations was practically equal in both groups, the potential (ovulated ova) and actual (number of embryos) fecundity was significantly higher in females having been paired off with SRBC-treated males. Main reproductive effects were registered at 3-5th day after injection, when specific antibody-forming process starts and males' scent becomes less attractive for females. On the base of previous and present data, the hypothesis is proposed that if the quality of a non-alternative mating partner is compromised by activation of specific immunity, a female tries to maximize its reproductive output (due to low chance of repeated copulation). This responsibility for the next generation is reminiscent of the Bible story about Lot and his daughters, and may help to sustain the species existence under conditions of parasitic press.
M P
MP
Moshkin
E Iu
EIu
Kondratiuk
E A
EA
Litvinova
L A
LA
Gerlinskaia
D000818:Animals; D001947:Breeding; D005260:Female; D005298:Fertility / Q000276:immunology*; D007110:Immunity, Active; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D012098:Reproduction / Q000276:immunology*; D012726:Sexual Behavior, Animal; D013076:Sperm Count