Pain in osteoarthritis.
This article focuses on pain associated with osteoarthritis (OA). It first describes the basic biology of articular cartilage and other joint structures and the defining features of the osteoarthritic disease process. Subsequently, the possible origins of pain in OA are discussed before embarking on how to manage this clinical entity. The emphasis is on the pharmacologic management of joint pain, and attention is paid to systemic therapeutic strategies as well as to local (intra-articular) treatment modalities. Nonmedical ways of modulating joint pain are briefly mentioned, but not extensively discussed, as these are outside the scope of this article.
Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, NL-3584 CM, Utrecht, The Netherlands. R.vanWeeren@uu.nl
P René
PR
van Weeren
Janny C
JC
de Grauw
D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000473:pathology; D006734:Horse Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D006736:Horses; D007270:Injections, Intra-Articular / Q000662:veterinary; D007596:Joints / Q000473:pathology; D010003:Osteoarthritis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*
D000700:Analgesics; D000893:Anti-Inflammatory Agents