New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue from Combretum yunnanense.
New chalcone and dimeric chalcones with 1,4- P-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4-6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2 and 3 were found to be most potent against HL-60 acute leukemia cells, with IC₅₀ values of 4.63, 4.07, and 1.26 µM, respectively.
Department of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan, P. R. China.
Ming-Mei
MM
Wu
Li-Qin
LQ
Wang
Yan
Y
Hua
Ye-Gao
YG
Chen
Yuan-Yuan
YY
Wang
Xing-Yao
XY
Li
Yan
Y
Li
Ting
T
Li
Xun-Yun
XY
Yang
Zheng-Rong
ZR
Tang
D016227:Benzoquinones / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D029624:Ferns / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
D016227:Benzoquinones; D047188:Chalcones; D010936:Plant Extracts; C004532:quinone