Efficacy and safety of lung recruitment in pediatric patients with acute lung injury.
OBJECTIVE
To assess the safety and efficacy of a recruitment maneuver, the Open Lung Tool, in pediatric patients with acute lung injury and acute respiratory distress syndrome.


METHODS
Prospective cohort study using a repeated-measures design.


METHODS
Pediatric intensive care unit at an urban tertiary children's hospital.


METHODS
Twenty-one ventilated pediatric patients with acute lung injury.


METHODS
Recruitment maneuver using incremental positive end-expiratory pressure.


RESULTS
The ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (Pao2/Fio2 ratio) increased 53% immediately after the recruitment maneuver. The median Pao2/Fio2 ratio increased from 111 (interquartile range, 73-266) prerecruitment maneuver to 170 (interquartile range, 102-341) immediately postrecruitment maneuver (p < .01). Improvement in Pao2/Fio2 ratio persisted with an increase of 80% over the baseline at 4 hrs and 40% at 12 hrs after the recruitment maneuver. The median Pao2/Fio2 ratio was 200 (interquartile range, 116-257) 4 hrs postrecruitment maneuver (p < .05) and 156 (interquartile range, 127-236) 12 hrs postrecruitment maneuver (p < .01). Compared with prerecruitment maneuver, the partial pressure of arterial carbon dioxide (Paco2) was significantly decreased at 4 hrs postrecruitment maneuver but not immediately after the recruitment maneuver. The median Paco2 was 49 torr (interquartile range, 44-60) prerecruitment maneuver compared with 48 torr (interquartile range, 43-50) immediately postrecruitment maneuver (p = .69), 45 torr (interquartile range, 41-50) at 4 hrs postrecruitment maneuver (p < .01), and 43 torr (interquartile range, 38-51) at 12 hrs postrecruitment maneuver. Recruitment maneuvers were well tolerated except for significant increase in Paco2 in three patients. There were no serious adverse events related to the recruitment maneuver.


CONCLUSIONS
Using the modified open lung tool recruitment maneuver, pediatric patients with acute lung injury may safely achieve improved oxygenation and ventilation with these benefits potentially lasting up to 12 hrs postrecruitment maneuver.
Department of Pediatrics, University of Wisconsin, Madison, WI, USA. jpboriosi@pediatrics.wisc.edu
Juan P
JP
Boriosi
Anil
A
Sapru
James H
JH
Hanson
Jeanette
J
Asselin
Ginny
G
Gildengorin
Vivienne
V
Newman
Katie
K
Sabato
Heidi R
HR
Flori
D055371:Acute Lung Injury / Q000150:complications / Q000628:therapy*; D000293:Adolescent; D001784:Blood Gas Analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D010100:Oxygen / Q000032:analysis; D011175:Positive-Pressure Respiration / Q000379:methods*; D011446:Prospective Studies; D012123:Pulmonary Ventilation; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
D010100:Oxygen