Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population.
Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients for the 4 and 6 variable MDRD and IDMS MDRD study equations based on the SCr recalibrated to CX3 and to IDMS were 0.73989/0.74254 and 0.99096/0.9554, respectively. Coefficients for the 4 and 6 variable MDRD equations based on the SCr measured by Jaffé method were 1.09825 and 1.04334, respectively. The modified equations showed better performances than the original equations. The novel 4 variable equations for Korean based on the SCr measured and recalibrated to IDMS were 107.904×SCr(-1.009)×age(-0.02) (×0.667, if woman) and 87.832×SCr(-0.882)×age(0.01) (×0.653, if woman), respectively. Modified estimations of the MDRD and IDMS MDRD study equations with ethnic coefficients and the novel equations improve the performance of GFR estimation for the overall renal function.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Chung Sik
CS
Lee
Ran-hui
RH
Cha
Youn-Hee
YH
Lim
Ho
H
Kim
Ka Heon
KH
Song
Namyi
N
Gu
Kyung Sang
KS
Yu
Chun Soo
CS
Lim
Jin Suk
JS
Han
Suhnggwon
S
Kim
Yon Su
YS
Kim
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003404:Creatinine / Q000097:blood; D004032:Diet; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000378:metabolism; D007674:Kidney Diseases / Q000208:ethnology* / Q000503:physiopathology; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D056910:Republic of Korea / Q000208:ethnology
D007444:Inulin; D003404:Creatinine