Concise total synthesis of largazole.
The concise total synthesis of largazole was accomplished. The key step included the use of the Nagao thiazolidinethione auxiliary for the diastereoselective acetate aldol reaction and it acts as an acylating agent for the peptide formation.
Peking Union Medical College & Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China.
Qiong
Q
Xiao
Li-Ping
LP
Wang
Xiao-Zhen
XZ
Jiao
Xiao-Yu
XY
Liu
Qian
Q
Wu
Ping
P
Xie
D002384:Catalysis; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D053778:Thiazolidines / Q000737:chemistry*
D047630:Depsipeptides; D013844:Thiazoles; D053778:Thiazolidines; C527895:largazole; C033089:thiazoline-2-thione