[Preparation of sustained release microspheres containing extracts from Caulis sinomenii with polylactic acid and their release property in vitro].
OBJECTIVE
To prepare polylactic acid microspheres containing total alkaloid extracts of Caulis sinomenii and study their release characteristics in vitro.


METHODS
Polylactic acid microspheres containing total alkaloid extracts of C. sinomenii were prepared by O/W emulsification solvent-evaporation process. The microspheres were characterized in terms of morphology, encapsulation efficiency, and particle size distribution. The effect of different conditions on release property of microspheres was studied.


RESULTS
The formed microspheres were spherical with smooth surfaces. The encapsulation efficiency and rate of drug loading were (83.4 +/- 5.63)% and (8.7-0.35)%, respectively. The distribution of particle size was uniform and the average size was (21.5 +/- 1.22) microm. In vitro release study revealed that the 32-hour accumulative release percentage reached 80%.


CONCLUSIONS
Polylactic acid microspheres containing total alkaloid extracts of C. sinomenii were prepared successfully. Microspheres with good sustained-release characteristics can be produced by controlling different process parameters.
Institute of Functional Fibers, Tianjin Municipal Key Laboratory of Fiber Modification and Functional Fibers, Tianjin Polytechnic University, Tianjin 300160, China.
Wen
W
Zhan
Xingxiang
X
Zhang
D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008863:Microspheres; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D032841:Sinomenium / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)