Genetic diversity of the major histocompatibility complex class II in Alaskan caribou herds.
We have sampled five different herds of caribou in Alaska to ascertain their major histocompatibility complex (MHC) class II diversity, and to assess whether the herds were significantly different in their MHC class II allele profiles. We complemented the MHC results with data from nine neutral microsatellite markers. The results indicate that while the microsatellites are diverse, there are no significant differences between the herds. However, for the MHC, we have shown that there is diversity at three of the four loci studied, the different herds have significantly different MHC class II allele profiles. It is also clear that although some of the herds have overlapping ranges, they are still different for their MHC class II alleles.
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. lorna.kennedy@manchester.ac.uk
L J
LJ
Kennedy
A
A
Modrell
P
P
Groves
Z
Z
Wei
R M
RM
Single
G M
GM
Happ
D000413:Alaska; D000818:Animals; D005786:Gene Expression Regulation; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci / Q000235:genetics; D014644:Genetic Variation; D005843:Geography; D006239:Haplotypes / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics; D012053:Reindeer / Q000235:genetics*; D013045:Species Specificity
D000949:Histocompatibility Antigens Class II