Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation.
OBJECTIVE
To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation.


METHODS
Retrospective, case-control study.


METHODS
University hospital, IVF center.


METHODS
Seventeen women with OHSS and 61 controls.


METHODS
None.


METHODS
FF and serum EG-VEGF and VEGF concentrations, IVF outcome.


RESULTS
FF and serum EG-VEGF concentrations showed a significant negative correlation with serum E(2) concentration on the day of hCG administration. FF, but not serum, VEGF concentrations also showed a significant negative correlation with serum E(2) concentrations on hCG day. The FF EG-VEGF, FF VEGF, and serum EG-VEFG concentrations were significantly lower in the OHSS group than in the non-OHSS group. There was no significant difference in serum VEGF concentrations. Among FF and serum EG-VEGF and VEGF concentrations, only FF EG-VEGF concentrations were significantly lower in patients with moderate OHSS than in those with mild OHSS.


CONCLUSIONS
FF and serum EG-VEGF concentrations may predict OHSS occurrence. Furthermore, FF EG-VEGF concentrations were significantly correlated with OHSS severity; thus, EG-VEGF appears to be more valuable than VEGF for predicting OHSS.
Department of Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Min-Zhi
MZ
Gao
Xiao-Ming
XM
Zhao
Zhao-Gui
ZG
Sun
Yan
Y
Hong
Lei-Wen
LW
Zhao
Hui-Qin
HQ
Zhang
D000328:Adult; D016022:Case-Control Studies; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D015571:Follicular Fluid / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007246:Infertility / Q000628:therapy; D009994:Osmolar Concentration; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D010062:Ovulation Induction / Q000009:adverse effects* / Q000379:methods; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D044967:Serum / Q000737:chemistry; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / Q000032:analysis* / Q000097:blood* / Q000378:metabolism; D055815:Young Adult
D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived