Exponentially growing layer-by-layer assembly to fabricate pH-responsive hierarchical nanoporous polymeric film and its superior controlled release performance.
A hierarchical nanoporous polymer film was fabricated through exponentially growing layer-by-layer assembly of weak polyelectrolytes without any template and post-treatment to greatly enhance loading capacity, release time and linear release range with pH-dependence for small molecules over the reported weak polyelectrolyte films, providing great potentials in controlled drug release applications.
School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
Weiyong
W
Yuan
Chang Ming
CM
Li
D000179:Acrylates; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D011094:Polyethyleneimine; D011108:Polymers / Q000737:chemistry*; D016062:Porosity
D000179:Acrylates; D003692:Delayed-Action Preparations; D011108:Polymers; D011094:Polyethyleneimine