Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature.
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
Department of Neonatology, University Hospital Maternity Ward of the Canary Islands, Las Palmas, Spain. pilybas@yahoo.es
Maria Pilar
MP
Bas Suárez
Jezabel
J
López Brito
Candelaria
C
Santana Reyes
Manuel
M
Gresa Muñoz
Rosario
R
Diaz Pulido
Jose Carlos
JC
Lodos Rojas
D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital* / Q000175:diagnosis* / Q000628:therapy