[Preparation and pharmacodynamic evaluation of diammonium glycyrrhizinate-loaded chitosan nanoparticles].
OBJECTIVE
To prepare the diammonium glycyrrhizinate-loaded chitosan nanoparticles (DG-CS NPs), and evaluate its pharmaceutical properties and pharmacodynamic effects on ulcerative colitis (UC).


METHODS
DG-CS NPs were prepared by spray drying method and optimized by orthogonal design. The morphology, size and in vitro release of DG-CS NPs were investigated. The therapeutic effects of DG-CS NPs on UC mice induced by dextran sulfate were evaluated preliminarily through disease active index method.


RESULTS
The size of DG-CS NPs with loading capacity about (51.25 +/- 1.75)% was in the range of 300-600 nm. The release of DG-CS NPs was associated with environmental pH value and displayed significant therapeutic and preventive effects on UC.


CONCLUSIONS
DG-CS NPs prepared by spray drying method showed efficacy on UC mice.
School of Phannrmacy, Medical College of Soochow University, Suzhou 21512, China.
Yunfeng
Y
Zhu
Qingri
Q
Cao
Shilin
S
Yang
Jinghao
J
Cui
D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy*; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D019695:Glycyrrhizic Acid / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*
D019695:Glycyrrhizic Acid; D048271:Chitosan; D016264:Dextran Sulfate