Scintigraphic, neuroradiological and clinical comparison in two patients with primary sporadic and two with secondary Fahr's disease.
Bilateral striopallidodentate calcification, usually termed Fahr's disease, can give rise to various clinical manifestations including hyperkinetic movement disorders or a hypokinetic Parkinsonian syndrome, behavioural and mood changes, cognitive deficits and even frank dementia. We describe four patients all of whom underwent a detailed scintigraphic, neuroradiological and clinical work-up: two had primary, sporadic Fahr's disease and two had Fahr's disease secondary to hypoparathyroidism. The neuroradiological and clinical studies disclosed similar anatomical and pathological changes in the four patients but variable and sometimes unexpected clinical manifestations. Both patients with primary forms had hypokinetic Parkinsonian syndrome, both patients with secondary forms had hyperkinetic movements. Dopamine autotransporter scan brain scintigraphy disclosed an unexpected unilateral putamen involvement despite substantially symmetric calcifications.
Division of Neurology, IRCCS Neuromed Institute, Via Atinense 18, 86077, Pozzilli (IS), Italy. giovannicaranci@tiscali.it
Giovanni
G
Caranci
Giovanni
G
Grillea
Francesco
F
Barbato
Alexandra
A
Brunetti
Tiziana
T
Tassinari
Mariarita
M
Di Ruzza
Francesco
F
Lena
Barbara
B
Gandolfi
Anna Elisa
AE
Castellano
Marcello
M
Bartolo
Claudio
C
Colonnese
Nicola
N
Modugno
Stefano
S
Ruggieri
Mario
M
Manfredi
D000368:Aged; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology; D011859:Radiography; D011877:Radionuclide Imaging