The use of immunohistochemistry in liver tumors.
A variety of benign and malignant neoplasms can be encountered in the liver. Hematoxylin and eosin-stained tissue sections alone may not yield sufficient information to definitively diagnose liver tumors; therefore, ancillary studies with immunohistochemical markers can play a crucial role in differentiating the different hepatic neoplasms. The recent development of oncofetoprotein glypican-3 has added to the value of immunohistochemistry in diagnosing liver cancer. This review discusses the immunohistochemical markers used most often in the diagnosis of hepatic tumors.
Department of Pathology, University of Washington School of Medicine, 1959 North East Pacific Street, NE140D, Box 356100, Seattle, WA 98195-6100, USA.
Elaine S
ES
Chan
Matthew M
MM
Yeh
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology*