Comparative effect of Ocimum sanctum, Commiphora mukul, folic acid and ramipril on lipid peroxidation in experimentally-induced hyperlipidemia.
Treatment with C. mukul and O. sanctum, showed a significant decrease in cholesterol and triglyceride levels respectively. O. sanctum also significantly increased serum HDL-cholesterol compared to control. Serum MDA levels were significantly reduced in all the treated groups compared to control suggesting that each of the drugs under study were effective in their free radical scavenging action. Erythrocyte SOD activity was increased in all the treatment groups with C. mukul showing the maximum effect followed by O. sanctum, folic acid and ramipril. The erythrocyte CAT activity was significantly increased in all the drug treated groups with maximum increase seen in O. sanctum and ramipril treated groups, whereas lesser effects were observed with C. mukul and folic acid groups. Thus, the indigenous drugs, C. mukul and O. sanctum had beneficial effect on hypercholesterolemic rabbit model, both in terms of lipid profile as well as antioxidant potential. Ocimum sanctum was found to be the most promising of all the drugs. Moreover, it could be hypothesized that these plant products along with folic acid and ramipril can be explored for synergistic effect for treatment for hypercholesterolemic conditions.
Department of Pharmacology, University College of Medical Sciences, Delhi 110 095, India. naresh.khanna@gmail.com
Naresh
N
Khanna
Deepika
D
Arora
Sumita
S
Halder
Ashish K
AK
Mehta
Gobind R
GR
Garg
Suman B
SB
Sharma
Prabha
P
Mahajan
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002374:Catalase / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D029744:Commiphora / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005492:Folic Acid / Q000494:pharmacology; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015394:Molecular Structure; D031339:Ocimum / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D017257:Ramipril / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014803:Vitamin B Complex / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D010936:Plant Extracts; D014280:Triglycerides; D014803:Vitamin B Complex; D008315:Malondialdehyde; D005492:Folic Acid; D002374:Catalase; D013482:Superoxide Dismutase; D017257:Ramipril