Vascular Protection by Ketanserin, a 5-HT(2) Serotonergic Receptor Antagonist?
Based upon experimental data, we advance the hypothesis that ketanserin, a 5-HT(2) serotonergic receptor antagonist, may provide protection against pathologies resulting from platelet-vessel wall interactions such as myointimal proliferation, vasospasms and thrombus formation. Clinical data support the possibility that such a vascular protection is operational also in man.
Dept. of Cardiovascular Pharmacology, Janssen Research Foundation, B-2340, Beerse, Belgium.
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Clerck
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Symoens
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Janssen