Laryngeal penetration and aspiration in individuals with stable COPD.
OBJECTIVE
Swallowing is closely coordinated with breathing but in COPD altered synchronization may predispose patients to a breach of the upper airway protective mechanisms. However, aspiration during swallow has never been shown in COPD. We examined penetration of liquid material into the airway of patients with COPD and correlated it with breathing-swallow patterns.


METHODS
A case-control study was performed. Patients with COPD (n = 16) were matched with normal control subjects (n = 15). Sub-mandibular videofluoroscopy was carried out during swallow of graduated volumes of barium to detect penetration (contrast enters the airway and may contact vocal folds) and aspiration (contrast passes glottis). Respiration was monitored simultaneously to gauge synchronization. Hospitalization and mortality were assessed after 36 months.


RESULTS
Penetration/aspiration scores were higher in patients with COPD (3.3 ± 0.7 vs 1.6 ± 0.4 in healthy controls, P = 0.03; mean ± SE). Penetration with aspiration was observed in 4/16 patients with COPD versus 1/15 controls (P = 0.07). Penetration with or without aspiration was found in 6/16 patients (P = 0.04). Inspiration-swallow-expiration patterns were favoured in individuals with COPD (P = 0.02). Penetration/aspiration was associated with higher respiratory rates (P = 0.01), reduced hyoid elevation (P = 0.04), post-swallow larynx penetration (P = 0.05) and oxygen desaturation (P = 0.01). There was a trend for the penetration/aspiration group to have an adverse outcome.


CONCLUSIONS
Upper airway protective mechanisms may be flawed in COPD, possibly through reduced coordination of breathing with swallowing. This abnormality may contribute to COPD morbidity in a subgroup of patients.
Respiratory and Sleep Medicine Physiology Diagnostic Imaging Monash Institute of Medical Research, Monash University and Medical Centre, Melbourne, Victoria, Australia.
Lydia
L
Cvejic
Richard
R
Harding
Thomas
T
Churchward
Anthony
A
Turton
Paul
P
Finlay
David
D
Massey
Philip G
PG
Bardin
Paul
P
Guy
D000368:Aged; D016022:Case-Control Studies; D003680:Deglutition Disorders / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007830:Larynx / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality / Q000503:physiopathology*; D053120:Respiratory Aspiration / Q000453:epidemiology / Q000503:physiopathology*; D012907:Smoking / Q000453:epidemiology / Q000503:physiopathology; D014827:Vocal Cords / Q000503:physiopathology