[Research progress of cells and cell-transplantation methods for periodontal tissue engineering].
OBJECTIVE
To introduce the cells and cell-transplantation methods for periodontal tissue engineering.


METHODS
Recent literature about application of cell-based therapy in periodontal tissue engineering was extensively reviewed, the cells and cell-transplantation methods were investigated.


RESULTS
Mesenchymal stem cells were important cell resources for periodontal tissue engineering, among which periodontal ligament stem cells were preferred. Bone marrow mesenchymal stem cells had several disadvantages in clinical application, and adipose-derived stem cells might be a promising alternative; different transplantation methods could all promote periodontal regeneration to some extent. Single-cell suspension injection could only promote a little gingival regeneration, and tissue engineered scaffolds still needed some improvement to be used in periodontal regeneration, while cell sheet technique, with great cell loading ability and no need of scaffolds, could promote regeneration of cementum, periodontal ligament, and alveolar bone under different conditions.


CONCLUSIONS
Multipotent stem cells are fit to be used in periodontal tissue engineering; improvement of cell-transplantation methods will further promote periodontal regeneration.
School of Dentistry, Tianjin Medical University, Tianjin 300070, PR China.
Wei
W
Li
Xuemei
X
Meng
D002454:Cell Differentiation; D010513:Periodontal Ligament / Q000166:cytology*; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds