[Preparation of multivariant-phospholipid complex of Ginkgo biloba extract].
OBJECTIVE
To prepare Ginkgo biloba extract multivariant-phospholipid complex(MGBP) and improve the vitro dissolution of ginkgo total flavonoids by adding another water-soluble carrier in phospholipid complex.


METHODS
MGBP was prepared using solvent evaporation method with Poloxamer-188 as the carrier and the multivariant complex was analyzed by DSC and X-diffraction technique. The physicochemical properties of the MGBP we also studied, including apparent oil-water distribution coefficients in different pH aqueous solution and its release in vitro.


RESULTS
The in vitro dissolution of ginkgo total flavonoids was significantly increased while the apparent oil-water distribution coefficient was improved after been made into multivariant-phospholipid complex.


CONCLUSIONS
The preparation technology of MGBP is simple and economic. MGBP can significantly increase the vitro dissolution of ginkgo total flavonoids and improve oil-water distribution coefficients, which can be the reference for the bioavailability in vivo in the further researches.
Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China. czpcpu2000@hotmail.com
Zhipeng
Z
Chen
Jun
J
Sun
Dan
D
Liu
Yanyu
Y
Xiao
Baochang
B
Cai
D020441:Ginkgo biloba / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D010743:Phospholipids / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D010743:Phospholipids; D014867:Water