Common pathogenic pathways in melanoma and Parkinson disease.
There is growing evidence in the scientific literature for shared risk and overlapping disease mechanisms in the development of cancer and Parkinson disease (PD). This association has recently been highlighted with respect to melanoma and PD. Therefore, we review and discuss the literature concerning this unexplained link. A striking overlap is observed in the tyrosine and L-dopa biosynthetic pathways suggesting a common disease mechanism associated with these 2 heterogeneous disorders that warrants further investigation.
Molecular Neuroscience Department, UCL Institute of Neurology, University College London, Queen Square, London, UK. cpaisan@gmail.com
Coro
C
Paisán-Ruiz
Henry
H
Houlden
D001932:Brain Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D054522:Group VI Phospholipases A2 / Q000235:genetics; D006801:Humans; D007980:Levodopa / Q000378:metabolism; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D009434:Neural Pathways / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine; D007980:Levodopa; D054522:Group VI Phospholipases A2; C516475:PLA2G6 protein, human