Azine-based receptor for recognition of Hg2+ ion: crystallographic evidence and imaging application in live cells.
A newly synthesized azine-based receptor (L) is found to show remarkable specificity toward the Hg(2+) ion in aqueous media over other metal ions. Coordination of L to Hg(2+) induces a detectable change in color and a turn-on fluorescence response. Restricted C=N isomerization of the azine moieties in the excited state as well as the Photoinduced Electron Transfer (PET) involving the lone pair of electrons of N(1)/N(2) on coordination of L to the Hg(2+) ion account for the turn-on fluorescence response. This reagent could be used for imaging the accumulation of Hg(2+) ions in Epithelial cell line KB 31 cells.
Central Salt and Marine Chemicals Research Institute (CSIR), Bhavnagar 364002, Gujarat, India.
Moorthy
M
Suresh
Amal Kumar
AK
Mandal
Sukdeb
S
Saha
E
E
Suresh
Amit
A
Mandoli
Rosa
R
Di Liddo
Pier Paolo
PP
Parnigotto
Amitava
A
Das
D001386:Azides / Q000737:chemistry*; D002413:Cations, Divalent / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival; D018360:Crystallography, X-Ray; D006801:Humans; D007536:Isomerism; D008628:Mercury / Q000737:chemistry*; D015394:Molecular Structure
D001386:Azides; D002413:Cations, Divalent; D008628:Mercury