Effects of enteral insulin on hypoxic changes in a rat model of necrotizing enterocolitis.
The aim of this study was to determine if oral administration of insulin would protect intestinal cell damage in a hypoxia-induced experimental NEC model in rats. Rats were subjected to hypoxia-reoxygenation and then were returned to standard conditions, other were treated with insulin. According to our results, oral insulin does not prevent mild intestinal mucosal changes during hypoxic injury in rats.
Begum
B
Yurdakok
Fuat Emre
FE
Canpolat
Diclehan
D
Orhan
Gulsev
G
Kale
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D020345:Enterocolitis, Necrotizing / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000860:Hypoxia / Q000150:complications*; D007328:Insulin / Q000008:administration & dosage*; D007413:Intestinal Mucosa / Q000473:pathology; D051381:Rats
D007328:Insulin