Determination of dithiocarbamates and milneb residues in foods by gas chromatography-mass spectrometry.
A highly sensitive gas chromatographic-mass spectrometric (GC-MS) method was developed for dithiocarbamates (DTCs) and milneb in foods. DTCs and milneb were extracted from foods with cysteine-EDTA solution as sodium salts, and methylated with methyl iodide. Methyl derivatives of DTCs and milneb were cleaned up on a neutral alumina mini column and determined by GC-MS. The mean recoveries of DTCs and milneb were in the range of 72-120%, except for methiram. The quantification limits were 0.01 mg/kg (as CS(2)) in foods except tea (0.1 mg/kg as CS(2)). The developed method was applied to 10 compounds (4 dimethyldithiocarbamates, 3 ethylenebisdithiocarbamates, polycarbamates, propineb and milneb).
Japan Food Research Laboratories, 6-11-10 Nagayama, Tama-shi, Tokyo, Japan. nakamuram@jfrl.or.jp
Munetomo
M
Nakamura
Satoko
S
Noda
Masaki
M
Kosugi
Noriko
N
Ishiduka
Kazushi
K
Mizukoshi
Makoto
M
Taniguchi
Satoru
S
Nemoto
D000818:Animals; D002119:Calcium Carbonate; D002951:Citrates; D018556:Crops, Agricultural / Q000737:chemistry; D003545:Cysteine; D004338:Drug Combinations; D004492:Edetic Acid; D005396:Fish Products / Q000032:analysis; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D005659:Fungicides, Industrial / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008277:Magnesium Oxide; D008460:Meat / Q000032:analysis; D008745:Methylation; D010573:Pesticide Residues / Q000032:analysis*; D013729:Terpenes; D013859:Thiocarbamates / Q000032:analysis*
D002951:Citrates; D004338:Drug Combinations; D005659:Fungicides, Industrial; D010573:Pesticide Residues; C050615:Suby's G solution; D013729:Terpenes; D013859:Thiocarbamates; C058585:methylionone; D008277:Magnesium Oxide; D004492:Edetic Acid; D002119:Calcium Carbonate; D003545:Cysteine