Comparisons between cats with normal and increased fPLI concentrations in cats diagnosed with inflammatory bowel disease.
OBJECTIVE
The aim of this study was to compare age, serum albumin and cobalamin concentrations, serum alanine amino transferase and alkaline phosphatase activities, feline inflammatory bowel disease clinical disease activity index, pancreatic ultrasound findings, intestinal histopathology scores, outcome, treatment and clinical response between cats diagnosed with inflammatory bowel disease with normal or increased serum feline pancreatic lipase immunoreactivity concentrations.


METHODS
Medical records for 23 cats diagnosed with inflammatory bowel disease and with serum feline pancreatic lipase immunoreactivity concentrations available were reviewed. Three groups were compared; cats with serum feline pancreatic lipase immunoreactivity concentrations 2·0 to 6·8 µg/l (group A), 6·9 to 11·9 µg/l (group B) and ≥12·0 µg/l (group C).


RESULTS
Sixteen of the 23 cats had increased serum feline pancreatic lipase immunoreactivity concentrations; 9 cats in group B and 7 cats in group C. The remaining seven cats were in group A. Cats with serum feline pancreatic lipase immunoreactivity concentrations ≥12·0 µg/l had significantly lower median serum albumin and cobalamin concentrations. No significant differences were identified between the three groups for age, serum alanine amino transferase and alkaline phosphatase activities, feline inflammatory bowel disease clinical disease activity index, pancreatic ultrasound findings, intestinal histopathology scores, clinical outcome, treatment or clinical response.


CONCLUSIONS
Hypoalbuminaemia and hypocobalaminaemia were more frequently observed in cats with serum feline pancreatic lipase immunoreactivity concentrations ≥12·0 µg/l.
Department of Veterinary Clinical Sciences, Royal Veterinary College, North Mymms, Hatfield, Hertfordshire AL9 7TA.
S
S
Bailey
L
L
Benigni
J
J
Eastwood
O A
OA
Garden
L
L
McMahon
K
K
Smith
J M
JM
Steiner
J S
JS
Suchodolski
K
K
Allenspach
D000367:Age Factors; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002371:Cat Diseases / Q000097:blood* / Q000201:enzymology*; D002415:Cats; D005260:Female; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000201:enzymology / Q000662:veterinary*; D008049:Lipase / Q000097:blood* / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000000981:diagnostic imaging / Q000201:enzymology; D011379:Prognosis; D012709:Serum Albumin / Q000378:metabolism*; D014463:Ultrasonography; D014805:Vitamin B 12 / Q000097:blood*
D012709:Serum Albumin; D000410:Alanine Transaminase; D008049:Lipase; D000469:Alkaline Phosphatase; D014805:Vitamin B 12