[Rheumatologic manifestations of sarcoidosis].
Sarcoidosis is a systemic granulomatous disease of unknown etiology. It has various clinical features. The most commonly affected organs are the lung, the lymph nodes, the eyes and the skin. Involvement of the musculoskeletal system is far less common and may be inaugural. Articular involvement is dominated by Lofgren syndrome and acute polyarthritis. Abarticular manifestations are often confounded with arthritis. Bone locations are dominated by sarcoidosis dactylitis and osteolysis. Muscular involvement is often unknown and can appear as 3 clinical features: spread form, myositique form or pseudotumoral form. Calcium balance disturbances are dominated by hypercalcemia which is often asymptomatique, but sometimes it reveal the sarcoidosis. Treatment of rheumatologic disorders often involves non steroidal antiinflammatory drugs, corticosteroids and methotrexate. Biological therapies such as the anti-TNFa and the anti-CD20 were showed to be effective in some case reports of severe and refractory disease.
Service de Rhumatologie institut Kassab d'orthopédie-Manouba Tunisia.
Wafa
W
Hamdi
Olfa
O
Néji
Mohamed Mehdi
MM
Ghannouchi
Dhia
D
Kaffel
Mohamed Montacer
MM
Kchir
D001847:Bone Diseases / Q000209:etiology*; D006801:Humans; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis