Potential role of selected biomarkers for predicting the presence and extent of coronary artery disease.
BACKGROUND
Since atherosclerosis may in part be an inflammatory disease, circulatory factors related to inflammation may be predictors of coronary artery disease. The aim of this study was to evaluate the association between the level of some circulating biomarkers and the extent of coronary artery disease.


METHODS
Blood samples were taken from 128 patients with stable forms of coronary heart disease. Macrophage chemoattractant protein-1 (MCP-1), matrix-metalloproteinase-3 (MMP-3), soluble CD40 ligand (sCD40L) and soluble tumour necrosis factor receptor-2 (sTNFR2) were measured by ELISA. Coronary angiography and grading with the SYNTAX score followed.


RESULTS
There was no significant interdependence of circulating MCP-1, sCD40L, sTNFR2 levels and SYNTAX score. MMP-3 levels were significantly different in subgroup with coronary artery disease (SYNTAX score > 0): 38.1 µg/l (13.6; 84.1) and subgroup without coronary artery disease (SYNTAX score = 0): 20.4 µg/l (13.1; 82.8), p=0.001. According to the Spearman correlation coefficient there was significant association between MMP-3 level and SYNTAX score (0.358, a=0.05).


CONCLUSIONS
Our data suggest association between the extent of coronary artery disease and circulating MMP-3. We failed to demonstrate any association with the other investigated biomarkers.
Department of Internal Medicine, T. Bata's Hospital, Zlin, Czech Republic. m.griva@seznam.cz
Martin
M
Griva
Robert
R
Naplava
Milada
M
Spendlikova
Jiri
J
Jarkovsky
Ota
O
Hlinomaz
Cestmir
C
Cihalik
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D023201:CD40 Ligand / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D008875:Middle Aged; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood
D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D047889:Receptors, Tumor Necrosis Factor, Type II; D023201:CD40 Ligand; D019278:Matrix Metalloproteinase 3