Acetoxypalladation of unactivated alkynes and capture with alkenes to give 1-acetoxy-1,3-dienes taking dioxygen as terminal oxidant.
A new and general protocol for the synthesis of 1-acetoxy-1,3-dienes by an acetoxypalladation/Heck cross-coupling/β-H elimination tandem process is described in which dioxygen is the terminal oxidant. Electron-rich and electron-deficient alkynes are both effective substrates in this system. It is the first example of acetoxypalladation of diarylalkynes.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou City, Guangdong Province 510640, China.
Peng
P
Zhou
Huanfeng
H
Jiang
Liangbin
L
Huang
Xianwei
X
Li