Effect of ADRA2A and BDNF gene-gene interaction on the continuous performance test phenotype.
Complex phenotypes such as performance on the continuous performance test (CPT) are likely to exhibit epistasis. Genetic polymorphisms of noradrenergic system and brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of noradrenergic neurons, have been reported to be associated with the performance on CPT. We evaluated the effect of the adrenergic α-2A receptor (ADRA2A) and BDNF gene-gene interaction on performance on the CPT in a Korean population with attention-deficit/hyperactivity disorder. In all, 122 participants with attention-deficit/hyperactivity disorder (8.6±2.3 years, 104 boys and 18 girls) completed the CPT. The DraI polymorphism of ADRA2A (rs583668) and rs11030101 polymorphism of BDNF were genotyped. Significant interaction effect was found of ADRA2A rs553668 and BDNF rs11030101 on response time variability (P=0.011) of the CPT. Our study provides preliminary evidence for the effect of the BDNF and ADRA2A gene-gene interaction on performance on the CPT in attention-deficit/hyperactivity disorder.
Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine, Korea.
Soo-Churl
SC
Cho
Jae-Won
JW
Kim
Hyo-Won
HW
Kim
Boong-Nyun
BN
Kim
Min-Sup
MS
Shin
Dae-Yeon
DY
Cho
Sun-Woo
SW
Jung
Un-Sun
US
Chung
Jung-Woo
JW
Son
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D001483:Base Sequence; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002648:Child; D017931:DNA Primers; D004843:Epistasis, Genetic; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
C547768:ADRA2A protein, human; D019208:Brain-Derived Neurotrophic Factor; D017931:DNA Primers; D018341:Receptors, Adrenergic, alpha-2