Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study.
BACKGROUND
This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previous vascular disease manifestations.


METHODS
The body mass index (in kilograms per square meter), plasma lipids, glucose, C-reactive protein, and white blood cell counts were evaluated. After full-mouth periodontal examinations, patients were categorized into the severe periodontitis group (SPG) or non-severe periodontitis group (NSPG).


RESULTS
The SPG showed significantly higher values of cholesterol-year scores, triglycerides, glucose, PWV, IMT, and diastolic blood pressure (DBP) (P ≤0.05) than the NSPG. After adjustment for traditional risk factors for atherosclerosis, only the association between severe periodontitis and DBP (odds ratio: 3.1; 95% CI: 1.1 to 8.5; P = 0.03) was confirmed.


CONCLUSIONS
In individuals with hFH, severe periodontitis was associated with a higher DBP, which suggests that severe periodontitis, itself, may contribute to the increased cardiovascular risk profile in this population.
Heart Institute, Medical School, University of São Paulo, São Paulo, SP, Brazil.
Carolina L Z
CL
Vieira
Patricia R
PR
Cury
Marcio H
MH
Miname
Lilton R
LR
Martinez
Luiz A
LA
Bortolotto
Isabela B
IB
Giuliano
Raul D
RD
Santos
Bruno
B
Caramelli
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000145:classification; D050197:Atherosclerosis / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D001783:Blood Flow Velocity / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D017536:Carotid Artery, Common / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D005260:Female; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications* / Q000235:genetics; D006973:Hypertension / Q000150:complications*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000150:complications*; D010865:Pilot Projects; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol