Total synthesis of apigenin-4'-yl 2-O-(p-coumaroyl)-β-D-glucopyranoside.
The first total synthesis of apigenin-4'-yl 2-O-(p-coumaroyl)-β-D-glucopyranoside, which exhibits good inhibitory activity against xanthine oxidase (XO), was accomplished in seven steps from a 1,2-blocked sugar unit and natural apigenin. A unique allyl protecting group, a phase-transfer-catalyzed (PTC) regioselective coupling reaction, and robustness in large-scale preparation are the merits of this synthetic strategy.
State key laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences (CAS), Beijing 100085, China.
Lei
L
Zhang
Guohua
G
Wei
Yuguo
Y
Du
D047310:Apigenin / Q000737:chemistry*; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D005960:Glucosides; D047310:Apigenin