The Molecular Genetics of Platelet Membrane Proteins and their Inherited Disorders.
The platelet membrane glycoproteins fulfil a vital function in platelet adhesion and aggrkgation. The advent of recombinant DNA technology has provided a wealth of new information on the sequence, structure, expression and chromosomal location of the genes encoding these proteins and Is now permitting the detailed molecular genetic analysis of both Bernard Soulier syndrome and Glanzmann's thrombasthenia.
Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, Chelsea, London SW3 6LR, UK.
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Cooper