Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis.
Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.
Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima. syagi@clin.med.tokushima-u.ac.jp
Shusuke
S
Yagi
Masashi
M
Akaike
Takashi
T
Iwase
Kenya
K
Kusunose
Toshiyuki
T
Niki
Koji
K
Yamaguchi
Kunihiko
K
Koshiba
Sumiko
S
Yoshida
Yuka
Y
Sumitomo-Ueda
Ken-ichi
K
Aihara
Yoichiro
Y
Hirata
Munkhbaatar
M
Dagvasumberel
Yoshio
Y
Taketani
Noriko
N
Tomita
Hirotsugu
H
Yamada
Takeshi
T
Soeki
Tetsuzo
T
Wakatsuki
Toshio
T
Matsumoto
Masataka
M
Sata
D000077300:Bosentan; D015444:Exercise / Q000502:physiology; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D013449:Sulfonamides / Q000627:therapeutic use*
D013449:Sulfonamides; D000077300:Bosentan