Chemokines as mediators of tumor angiogenesis and neovascularization.
Chemokines are a superfamily of structurally homologous heparin-binding proteins that influence tumor growth and metastasis. Several members of the CXC and CC chemokine families are potent inducers of neovascularization, whereas a subset of the CXC chemokines are potent inhibitors. In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization.
Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA, USA.
Ellen C
EC
Keeley
Borna
B
Mehrad
Robert M
RM
Strieter
D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D009389:Neovascularization, Pathologic
D018925:Chemokines