Revisiting caveolin trafficking: the end of the caveosome.
In this issue, a study by Hayer et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003086) provides insights into the trafficking of caveolins, the major membrane proteins of caveolae. As well as providing evidence for ubiquitin-mediated endosomal sorting and degradation of caveolin in multivesicular bodies (MVBs), the new findings question the existence of a unique organelle proposed nine years ago, the caveosome.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. R.Parton@imb.uq.edu.au
Robert G
RG
Parton
Mark T
MT
Howes
D000818:Animals; D021941:Caveolae / Q000378:metabolism*; D022461:Caveolins / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D057146:Multivesicular Bodies / Q000378:metabolism; D021381:Protein Transport; D025801:Ubiquitin / Q000378:metabolism
D022461:Caveolins; D025801:Ubiquitin