De novo renal cell carcinoma of native and graft kidneys in renal transplant recipients.
OBJECTIVE
• To access the epidemiological, clinical and survival features of renal transplant patients with de novo renal cell carcinoma of native and graft kidneys.


METHODS
• We performed a retrospective examination of the data of 2001 consecutive renal transplant recipients at our centre between November 1979 and January 2010.


RESULTS
• In the patient cohort examined, 30 renal cell carcinomas were observed in 26 individuals (incidence 1.5%) with 25 tumours in the native and five in allograft kidneys. Mean tumour size in surgical specimens was 44 ± 36 mm. The rate of papillary cancer was 37.5%. • After a mean follow-up of 58.6 ± 62.3 months, 15.4% of the patients died from cancer and 57.7% were in complete remission. • Overall and tumour-specific survival rates at 1, 5 and 10 years were 86.1%, 75.1% and 43.8%, and 90.4%, 83.5% and 66.8%, respectively.


CONCLUSIONS
• Due to increasingly improved survival after renal transplantation, de novo malignancies might soon become the main cause of intermediate- or long-term mortality. • Current data support an increased risk of renal cell carcinoma in renal transplant recipients in a particularly aggressive way, but low tendency for metachronous contralateral evolution. • With continuous radiological follow-ups, acceptable oncological outcome can be achieved. Graft tumours may have a favourable prognosis.
Department of Urology and Pediatric Urology, University Medical Center Frankfurt, Germany. igor_tsaur@hotmail.com
Igor
I
Tsaur
Nicholas
N
Obermüller
Dietger
D
Jonas
Roman
R
Blaheta
Eva
E
Juengel
Ernst-Heinrich
EH
Scheuermann
Heinz-Georg
HG
Kachel
Athanasios
A
Karalis
Michael
M
Probst
D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011379:Prognosis