Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells.
Apigenin suppressed tumor necrosis factor α-induced cell proliferation and prostaglandin E2 expression via the attenuation of nuclear factor κB pathway in endometriotic stromal cells in vitro. Apigenin reduced the mitogenic activity and inflammatory reaction in endometriotic stromal cells.
Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
Kana
K
Suou
Fuminori
F
Taniguchi
Yukiko
Y
Tagashira
Tomoiki
T
Kiyama
Naoki
N
Terakawa
Tasuku
T
Harada
D000328:Adult; D047310:Apigenin / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D004717:Endometrium / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
D006131:Growth Inhibitors; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D047310:Apigenin; D015232:Dinoprostone