[High dose chemotherapy combined with peripheral blood stem cell transplantation (PBSCT) in the treatment of patients with small cell lung cancer].
BACKGROUND
To investigate the therapeutic effect and safety of PBSCT combined with high dose chemotherapy in the treatment of small cell lung cancer(SCLC).


METHODS
From March, 1994 to June, 1999, high dose chemotherapy combined with PBSCT was carried out in 20 patients with SCLC. Eight patients were in CR status while twelve patients were for salvaging therapy. Allo-PBSCT was performed in 1 patient and Auto-PBSCT in 19 patients. After mobilization of stem cell, mononeuclear cell (MNC) was collected for ≥3.0×10⁸/kg, CD34+ cell≥2.0×10⁶/kg. The high dose chemotherapy included carboplatin 350 mg/m²×3 days, VP-16 120 mg/m²×5 days, and E-ADM 40 mg/m²×2 days.


RESULTS
Encouraging results were achieved in 8 patients who were in CR status. Seven of the eight patients survived after Auto-PBSCT. One patients survived more than 1 year, 4 cases over 2 years, and 3 cases over 3 years. Of the 3 patients, 2 survived more than 4 years. In the group of salvaging therapy, response was good, however there was no long-term survival and median remission time was only 3.5 months.


CONCLUSIONS
High dose chemotherapy combined with PBSCT in the treatment of SCLC with CR status is feasible and safe, although the side effects are severe too. It is worth further studying on clinical practice.
Department of Medical Oncology (Division 1), 307 Hospital, Beijing 100039, P.R.China.
Y
Y
Bao
H
H
Su
G
G
Shen
X
X
Yuan
H
H
Gao
W
W
Yang