A bioelectronic platform using a graphene-lipid bilayer interface.
The electronic properties of graphene can be modulated by charged lipid bilayer adsorbing on the surface. Biorecognition events which lead to changes in membrane integrity can be monitored electrically using an electrolyte-gated biomimetic membrane-graphene transistor. Here, we demonstrate that the bactericidal activity of antimicrobial peptides can be sensed electrically by graphene based on a complex interplay of biomolecular doping and ionic screening effect.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Priscilla Kailian
PK
Ang
Manu
M
Jaiswal
Candy Haley Yi Xuan
CH
Lim
Yu
Y
Wang
Jagadish
J
Sankaran
Ang
A
Li
Chwee Teck
CT
Lim
Thorsten
T
Wohland
Ozyilmaz
O
Barbaros
Kian Ping
KP
Loh
D000595:Amino Acid Sequence; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000737:chemistry*; D015374:Biosensing Techniques; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D004583:Electrons; D006090:Gram-Negative Bacteria / Q000166:cytology / Q000187:drug effects; D006108:Graphite / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008969:Molecular Sequence Data; D013499:Surface Properties; D014173:Transistors, Electronic
D023181:Antimicrobial Cationic Peptides; D008051:Lipid Bilayers; D006108:Graphite