Antileishmanial sesquiterpenes from the Brazilian red alga Laurencia dendroidea.
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (-)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity.
Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Fernanda Lacerda
FL
da Silva Machado
Wallace
W
Pacienza-Lima
Bartira
B
Rossi-Bergmann
Lísia Mônica
LM
de Souza Gestinari
Mutue T
MT
Fujii
Joel
J
Campos de Paula
Sônia Soares
SS
Costa
Norberto Peporine
NP
Lopes
Carlos Roland
CR
Kaiser
Angélica Ribeiro
AR
Soares
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D044722:Laurencia / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D010936:Plant Extracts; D012717:Sesquiterpenes