Vagrant stem cells draft their gene companions.
In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.
Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98915, USA.
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