Tuberous sclerosis complex renal disease.
Although not as common as other genetic renal diseases such as autosomal dominant polycystic kidney disease, patients with tuberous sclerosis complex frequently have significant renal involvement. Recent revelations in the cell biology of these renal disease manifestations as well as effective therapies for tuberous sclerosis complex-related renal issues have heralded hope of improved renal survival and improved quality of life for the TSC patient. This review specifically addresses some of the major renal manifestations of this disease.
Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.
Bradley P
BP
Dixon
John C
JC
Hulbert
John J
JJ
Bissler
D018207:Angiomyolipoma / Q000209:etiology; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000209:etiology; D007680:Kidney Neoplasms / Q000209:etiology; D009154:Mutation / Q000235:genetics; D053040:Nephrolithiasis / Q000209:etiology; D014402:Tuberous Sclerosis / Q000150:complications* / Q000235:genetics / Q000503:physiopathology*; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000235:genetics
D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins