Benign prostatic hyperplasia. Clinical treatment can complicate cataract surgery.
OBJECTIVE
To investigate the effects of alpha-1 adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia (BPH) regarding potential risks of complications in the setting of cataract surgery.


OBJECTIVE
To address recommendations, optimal control therapy, voiding symptoms and safety within the setting of cataract surgery.


METHODS
A comprehensive literature review was performed using MEDLINE with MeSH terms and keywords "benign prostatic hyperplasia", "intraoperative floppy iris syndrome", "adrenergic alpha-antagonist" and "cataract surgery". In addition, reference lists from identified publications were reviewed to identify reports and studies of interest from 2001 to 2009.


RESULTS
The first report of intraoperative floppy iris syndrome (IFIS) was observed during cataract surgery in patients taking systemic alpha-1 AR antagonists in 2005. It has been most commonly seen related to use of tamsulosin. Changes of medication and washout periods of up to 2 weeks have been attempted to reduce the risk of complications in the setting of cataract surgery.


CONCLUSIONS
Patients under clinical treatment for BPH should be informed about potential risks of this drug class so that it can be discuss with their healthcare providers, in particular urologist and ophthalmologist, prior to cataract surgery.
Department of Urology, Faculty of Medicine of Sao Jose do Rio Preto, Sao Paulo, Brazil. fnfacio@yahoo.com.br
Fernando
F
Facio
Renata
R
Kashiwabuschi
Yutaro
Y
Nishi
Ricardo
R
Leao
Peter
P
McDonnell
Arthur
A
Burnett
D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D002387:Cataract Extraction / Q000009:adverse effects; D006801:Humans; D007498:Iris / Q000187:drug effects; D007499:Iris Diseases / Q000139:chemically induced*; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D012307:Risk Factors
D058668:Adrenergic alpha-1 Receptor Antagonists