miRNA: small molecules as potential novel biomarkers in cancer.
Four different types of small RNAs functionally associated with gene silencing have been discovered in animals including small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). Experimental evidence suggests that miRNAs regulate the expression of more than 30% of protein-coding genes. These molecules can also act as oncogenes or tumor suppressors. Expression profiling has revealed characteristic miRNA signatures not only in human cancers but also in serum and blood cells of cancer patients. Numerous human miRNA genes map to chromosomal regions which are susceptible to amplification, deletion or translocation in the process of tumor development. Despite the pivotal role of miRNA in cancer precise mechanisms of action are yet to be elucidated. This review is focused on recent findings related to the emerging field of miRNA serving as novel potential biomarkers in cancer diagnosis, prognosis and possibly, therapies.
Division of Molecular Genetics, Institute of Human Genetics, University of Tübingen, Germany.
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Shah
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Leidinger
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Blin
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Meese
D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008970:Molecular Weight; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
D014408:Biomarkers, Tumor; D035683:MicroRNAs