Impact of statins on cardiovascular outcomes in renal transplant recipients: a systematic review.
Patients with chronic kidney disease including renal transplant recipients (RTRs) have a markedly higher prevalence of cardiovascular disease than the general population. Many trials have established the role of statins in the prevention of cardiovascular mortality, not only by decreasing the low density lipoprotein-cholesterol levels but also by their pleotropic effects. These data from the general population may not be applicable to RTRs as these patients have different cardiovascular risk profiles. Till date, only a few prospective, randomized trials have assessed the use of statins in RTRs with regards to cardiovascular outcomes. The Assessment of Lescol in Renal Transplant trial, the largest trial so far, suggested that dyslipidemia management with statins in RTRs is associated with a significant reduction in the incidence of cardiac death and nonfatal myocardial infarction (although differences in the combined primary end point were not statistically significant). The current guidelines from National Kidney Foundation for managing dyslipidemia in RTRs recommend managing all chronic kidney disease patients as a coronary heart disease equivalent. The task group for drafting these guidelines concluded that based on the currently available evidence, additional studies may be needed in RTRs to confirm and extend the results of Assessment of Lescol in Renal Transplant trial.
Department of Medicine, Chicago Medical School, IL 60064, USA.
Najindra
N
Maharjan
Updesh
U
Bedi
Rohit
R
Arora
Sanjay
S
Bhandari
Pradeep
P
Dahal
Sandeep
S
Khosla
D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000502:physiology; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000150:complications; D016030:Kidney Transplantation; D016896:Treatment Outcome
D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors