Bending the path to TOR.
Cells sense and respond to physical stresses through mechanotransduction, a process that converts mechanical stimuli into biochemical signals. The bending of primary cilia has now been shown to modulate TOR signalling to negatively regulate cell size.
Brian M
BM
Wiczer
Adem
A
Kalender
George
G
Thomas
D055372:AMP-Activated Protein Kinases; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D002923:Cilia / Q000378:metabolism*; D000076222:Mechanistic Target of Rapamycin Complex 1; D040542:Mechanotransduction, Cellular; D051379:Mice; D046912:Multiprotein Complexes; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases
D046912:Multiprotein Complexes; D011506:Proteins; D000076222:Mechanistic Target of Rapamycin Complex 1; D017346:Protein Serine-Threonine Kinases; C491654:Stk11 protein, mouse; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases