Disseminated cryptococcosis and fluconazole resistant oral candidiasis in a patient with acquired immunodeficiency syndrome (AIDS).
Disseminated cryptococcosis and recurrent oral candidiasis was presented in a-heterosexual AIDS patient. Candida tropicalis (C.tropicalis) was isolated from the oral pseudomembranous plaques and Cryptococcus neoformans (C. neoformans) was isolated from maculopapular lesions on body parts (face, hands and chest) and body fluids (urine, expectorated sputum, and cerebrospinal fluid). In vitro drug susceptibility testing on the yeast isolates demonstrated resistance to fluconazole acquired by C. tropicalis which was a suggestive possible root cause of recurrent oral candidiasis in this patient.
Microbiology Laboratory WQA, EPCOR, Edmonton, Canada. rkothava@epcor.ca
Rajendra J
RJ
Kothavade
Chetan M
CM
Oberai
Arvind G
AG
Valand
Mehroo H
MH
Panthaki
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology; D001826:Body Fluids / Q000382:microbiology; D041022:Candida tropicalis / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D003453:Cryptococcosis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009061:Mouth Mucosa / Q000382:microbiology / Q000473:pathology; D012867:Skin / Q000382:microbiology / Q000473:pathology
D000935:Antifungal Agents; D015725:Fluconazole