Serum resistin levels and cardiovascular events in patients undergoing percutaneous coronary intervention.
OBJECTIVE
Resistin is an adipocytokine that may link inflammation and atherosclerosis.We studied the associations of resistin levels with cardiovascular events and restenosis.


METHODS
We measured pre-procedural serum resistin levels in 140 patients with coronary artery disease undergoing elective percutaneous coronary intervention (PCI), of whom 97 had a stent. Restenosis was defined as > 50% stenosis at follow-up angiography. Patients were followed for 3 years for major adverse cardiovascular events (MACE).


RESULTS
At 8±6 months after PCI, reangiography was performed in 94 (67%) patients, of whom 42 had restenosis. Between 42 patients with restenosis and 52 without restenosis, resistin (4.5±2.6 vs. 4.5±2.5 ng/mL) and Creactive protein (CRP) (median 0.70 vs. 0.70 mg/L) levels did not differ. During 3-year follow-up, MACE occurred in 24 patients (1 death, 21 unstable angina, 2 stroke). Compared with 116 patients without MACE, 24 with MACE had higher resistin (5.4±2.4 vs. 4.3±2.5 ng/mL) and CRP (1.30 vs. 0.60 mg/L) levels (p< 0.05). Patients with MACE more often had resistin >4.0 ng/mL than without MACE (75% vs. 35%, p< 0.001). Resistin correlated with CRP levels (r= 0.31). To clarify the association between MACE and resistin, patients were divided into 2 groups by resistin levels. Kaplan-Meier analysis showed a lower event-free survival rate in patients with resistin > 4.0 ng/mL than without it (p< 0.001). On multivariate analysis, resistin, but not CRP, was an independent predictor of MACE. The hazard ratio for MACE was 3.6 (95%CI=1.4-9.2) for resistin > 4.0 ng/mL.


CONCLUSIONS
Serum resistin levels were found to be associated with further cardiovascular events in patients undergoing PCI.
Department of Cardiology, National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan. ymomiyamajp@yahoo.co.jp
Yukihiko
Y
Momiyama
Reiko
R
Ohmori
Harumi
H
Uto-Kondo
Nobukiyo
N
Tanaka
Ryuichi
R
Kato
Hiroaki
H
Taniguchi
Koh
K
Arakawa
Haruo
H
Nakamura
Fumitaka
F
Ohsuzu
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000628:therapy*; D023903:Coronary Restenosis / Q000097:blood / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D015607:Stents
C499624:RETN protein, human; D052243:Resistin; D002097:C-Reactive Protein