Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-Producing Enterobacteriaceae.
Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum β-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-β-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 μg/ml, including those with metallo-β-lactamases.
Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, London, United Kingdom. david.livermore@hpa.org.uk
David M
DM
Livermore
Shazad
S
Mushtaq
Marina
M
Warner
Jiancheng
J
Zhang
Sunil
S
Maharjan
Michel
M
Doumith
Neil
N
Woodford
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002442:Ceftazidime / Q000494:pharmacology*; D004338:Drug Combinations; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D004338:Drug Combinations; C543519:avibactam; D002442:Ceftazidime; D001618:beta-Lactamases; C063912:carbapenemase; D001398:Aztreonam