Platelet cAMP and cGMP Phosphodiesterases.
Platelets respond to a wide variety of exogenous agonists that bind to distinct receptors on the platelet surface resulting in the intracellular generation of second messengers or the opening of ion channels, setting off a cascade of events leading to both physical and functional changes in the platelet. The cyclic nucleotides, cyclic adenosine 3'5'-monophosphate (CAMP) and cyclic guanosine 3'5'-monophosphate (cGMP) initiate a sequence of intracellular events that modulate many of these reactions in the platelet.
Sol Sherry Thrombosis Research Center, 3400 North Broad Street, Philadelphia, PA, 19140, USA, (215) 707-4684, (215) 707-2783.
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Sheth
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Colman