Recurrent idiopathic acute hepatitis-associated aplastic anemia/pancytopenia fourteen years after initial episode.
Aplastic anemia following viral hepatitis is a condition well recognized in the medical literature. Although hepatitis-associated aplastic anemia is an uncommon syndrome, there are several reports in the literature describing such cases. In these reports, aplastic anemia generally occurs following a viral infection, including parvovirus B19, but may also be idiopathic. The etiology of both the hepatic injury and the bone marrow failure is speculated to be immune-mediated. We report a patient who suffered acute idiopathic hepatitis and severe pancytopenia fourteen years after a similar episode in childhood. This is only the second case report of acute hepatitis in association with bone marrow failure and aplastic anemia in childhood with sudden recurrence many years later in adulthood.
University of British Columbia, Vancouver, Canada.
Nawal
N
Al Nahdi
Holly
H
Wiesinger
Heather
H
Sutherland
Eric M
EM
Yoshida
D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001706:Biopsy; D016572:Cyclosporine / Q000627:therapeutic use; D006505:Hepatitis / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008297:Male; D010198:Pancytopenia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine