Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy.
This review, divided into three sections, describes the contribution of the chemists' community to the development and application of triple helix strategy by using artificial nucleic acids, particularly for the recognition of DNA sequences incorporating base pair inversions. Firstly, the development of nucleobases that recognise CG inversion is surveyed followed secondly by specific recognition of TA inverted base pair. Finally, we point out in the last section recent perspectives and applications, driven from knowledge in nucleic acids interactions, in the growing field of nanotechnology and supramolecular chemistry at the border area of physics, chemistry and molecular biology.
Laboratoire de Chimie des Molécules Bioactives et des Arômes, LCMBA, UMR 6001, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France.
Vincent
V
Malnuit
Maria
M
Duca
Rachid
R
Benhida
D020137:Base Pair Mismatch; D002241:Carbohydrates / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry
D002241:Carbohydrates; D009841:Oligonucleotides; D004247:DNA