Diabetes mellitus in elkhounds is associated with diestrus and pregnancy.
BACKGROUND
Female Elkhounds are shown to be at increased risk for diabetes mellitus, and occurrence of diabetes during pregnancy has been described in several cases.


OBJECTIVE
Onset of diabetes mellitus in Elkhounds is associated with diestrus.


METHODS
Sixty-three Elkhounds with diabetes mellitus and 26 healthy controls.


METHODS
Medical records from 63 Elkhounds with diabetes were reviewed and owners were contacted for follow-up information. Blood samples from the day of diagnosis were available for 26 dogs. Glucose, fructosamine, C-peptide, growth hormone (GH), insulin-like growth factor-1, progesterone, and glutamate decarboxylase isoform 65-autoantibodies were analyzed and compared with 26 healthy dogs. Logistic models were used to evaluate the association of clinical variables with the probability of diabetes and with permanent diabetes mellitus after ovariohysterectomy (OHE).


RESULTS
All dogs in the study were intact females and 7 dogs (11%) were pregnant at diagnosis. The 1st clinical signs of diabetes mellitus occurred at a median of 30 days (interquartile range [IQR], 3-45) after estrus, and diagnosis was made at a median of 46 days (IQR, 27-62) after estrus. Diabetes was associated with higher concentrations of GH and lower concentrations of progesterone compared with controls matched for time after estrus. Forty-six percent of dogs that underwent OHE recovered from diabetes with a lower probability of remission in dogs with higher glucose concentrations (odds ratio [OR], 1.2; P=.03) at diagnosis and longer time (weeks) from diagnosis to surgery (OR, 1.5; P=.05).


CONCLUSIONS
Diabetes mellitus in Elkhounds develops mainly during diestrus and pregnancy. Immediate OHE improves the prognosis for remission of diabetes.
Department of Clinical Sciences, Swedish University of Agricultural Sciences, and Department of Medical Sciences, University Hospital, Uppsala, Sweden. tove.fall@kv.slu.se
T
T
Fall
A
A
Hedhammar
A
A
Wallberg
N
N
Fall
K M
KM
Ahlgren
H H
HH
Hamlin
K
K
Lindblad-Toh
G
G
Andersson
O
O
Kämpe
D000818:Animals; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000209:etiology / Q000662:veterinary*; D004031:Diestrus / Q000378:metabolism*; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D016015:Logistic Models; D011247:Pregnancy; D012307:Risk Factors