[Increase of mutation level in tissues of goby and fry of sturgeon under conditions of block by antibodies against serotonin-modulated anticonsolidation protein].
The work present data on studies of a decreased activity of serotoninergic system on the level of mutagenic changes (the micronuclear test) in the goby Neogobius fluviatilis and the fry if sturgeon Acipenser güldenstädti persicus. It has been shown that the long exposure of the animals to conditions of industrial and oil pollution leads to a significant decrease in their liver of the level of serotonin-modulated anticonsolidation protein (SMAP) correlating directly with the serotonin level as well as to sharp increase of the level of micronuclei in erythrocytes. The intramuscular administration of anti-SMAP polyclonal antibodies to the fry of the sturgeon produces a significant increase of the amount of micronuclei as compared with that in the animals injected with non-immune gamma-globulin. The obtained results allow concluding that the decrease of activity of the serotoninergic system is the mechanism that is triggered with adverse environmental factors and realizes mutagenic damages in the modified genetic apparatus.
A A
AA
Mekhtiev
G M
GM
Palatnikov
S K
SK
Movsum-zade
R Iu
RIu
Kasimov
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D029941:Fish Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005399:Fishes / Q000235:genetics / Q000378:metabolism*; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced; D018482:Muscle, Skeletal / Q000378:metabolism; D016296:Mutagenesis / Q000187:drug effects*; D009154:Mutation; D010578:Petroleum / Q000009:adverse effects*; D012701:Serotonin / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
D000906:Antibodies; D029941:Fish Proteins; D010578:Petroleum; D014874:Water Pollutants, Chemical; D012701:Serotonin