A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides.
A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd(2)(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.
Department of Process Research, Merck Research Laboratories, P.O. Box 2000 Rahway, New Jersey 07065, USA. michael_luzung@merck.com
Michael R
MR
Luzung
Jigar S
JS
Patel
Jingjun
J
Yin
D003432:Cross-Linking Reagents; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
D003432:Cross-Linking Reagents; D006843:Hydrocarbons, Chlorinated; D007202:Indicators and Reagents; D009942:Organometallic Compounds