An ATPase R-finger leaves its print on transcriptional activation.
Bacterial enhancer-binding proteins (bEBPs) are AAA+ ATPases that remodel σ⁵⁴-RNA polymerase holoenzyme for transcription. Chen et al., in this issue of Structure, show the R-finger, a conserved AAA+ arginine residue, drives structural changes that allow the ATP-bound bEBP to engage σ⁵⁴ en route to remodeling.
Division of Biology, Room 448, SAFB, Imperial College Road, Imperial College, London SW72AZ, UK. m.buck@imperial.ac.uk
Martin
M
Buck
Timothy R
TR
Hoover