Adjacent substitutions (γ352Gly→Cys and 353Thr→Pro) in fibrinogen Ilam cause diminished γ chain expression.
Stephen O
SO
Brennan
Jocelyn
J
Oliver
Ryan L
RL
Davis
D000328:Adult; D019943:Amino Acid Substitution; D025861:Blood Coagulation Disorders, Inherited / Q000097:blood / Q000235:genetics*; D003062:Codon; D004252:DNA Mutational Analysis; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D015241:Fibrinogens, Abnormal / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D009154:Mutation; D010641:Phenotype; D011487:Protein Conformation; D017510:Protein Folding; D013329:Structure-Activity Relationship
D003062:Codon; D015241:Fibrinogens, Abnormal; C027539:fibrinopeptides gamma; D005340:Fibrinogen