[Prophylaxis in haemophilia B. Prevention of bleeds and FIX consumption].
Based on the documentation from patients with severe haemophilia B (FIX:C <1%) in home treatment the positive effect of continuous prophylaxis compared to on demand treatment was investigated over one year in a retrospective study from a single treatment centre (Centre for Haemostaseology Muenster). The advantage of the reduction in the number of bleeding episodes by 90% was opposed by a threefold higher consumption of FIX concentrates and a fourfold higher exposure of the patients to intravenous injections.
Institut für Thrombophilie und Hämostaseologie, Praxis Dr. med. Hartmut Pollmann, Loerstraße 19, 48143 Münster. ith@haemophilie-zentrum.de
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D000293:Adolescent; D000328:Adult; D005164:Factor IX / Q000008:administration & dosage / Q000627:therapeutic use*; D002836:Hemophilia B / Q000150:complications / Q000188:drug therapy*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D012189:Retrospective Studies; D055815:Young Adult
D005164:Factor IX