Combined trabeculotomy and trabeculectomy: outcome for primary congenital glaucoma in a West African population.
OBJECTIVE
To evaluate the surgical outcome of combined trabeculotomy-trabeculectomy in Ghanaian children with primary congenital glaucoma.


METHODS
A retrospective case series involving 19 eyes of 12 consecutive children with primary congenital glaucoma who had primary trabeculotomy-trabeculectomy from 12 August 2004 to 30 June 2008, at the Korle-Bu Teaching Hospital, Ghana. Main outcome measures were preoperative and postoperative intraocular pressures, corneal diameter, corneal clarity, bleb characteristics, duration of follow-up, surgical success, and complications.


RESULTS
A total of 19 eyes of 12 patients met the inclusion criteria. Six of the patients were males. Mean age at diagnosis was 4.4 (range 2-8) months. Mean age at surgery was 5.9 months (range 3-16). Eight (67%) infants had bilateral disease. Mean duration of follow-up was 13.1 (range 5-38) months. The preoperative mean horizontal corneal diameter was 13.4 ± 1.1(range 12-16) mm. Complete success (intraocular pressure <21 mm Hg) was obtained in 15 (79%) eyes. The probability of success was 94.4, 83.3, 66.7, 44.4, 38.9, 33.3, and 13.3% at 3, 6, 9, 12, 15, 18, and 21 months, respectively (Kaplan-Meier analysis). All eyes had corneal oedema preoperatively. Seventeen eyes (90%) had clear cornea at their last follow-up. Mean preoperative and postoperative intraocular pressures were 30.3 ± 8.8 and 18.1 ± 6.8 mm Hg respectively (P<0.001, t-test). Twelve (63%) eyes had well-functioning blebs at the last follow-up. One eye (5%) developed seclusio pupillae and cataract postoperatively.


CONCLUSIONS
The overall success for combined trabeculotomy-trabeculectomy in Ghanaian children with primary congenital glaucoma was 79%. The probability of success reduced from more than 66% in the first 9 months postoperatively to below 45% after that.
Department of Surgery, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana. vadessuman@yahoo.com
V A
VA
Essuman
I Z
IZ
Braimah
T A
TA
Ndanu
C T
CT
Ntim-Amponsah
D003315:Cornea / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005869:Ghana; D005901:Glaucoma / Q000151:congenital* / Q000601:surgery*; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure; D053208:Kaplan-Meier Estimate; D008297:Male; D017063:Outcome Assessment, Health Care; D011184:Postoperative Period; D057234:Preoperative Period; D012189:Retrospective Studies; D014130:Trabeculectomy / Q000379:methods*