Tissue factor, lipid rafts, and microparticles.
Evidence is emerging that tissue-factor-bearing microparticles and other microparticles arise from regions of the parent cell's plasma membrane that are rich in lipid rafts. In this brief review, we summarize the evidence for the raft origins of microparticles and the implications of these origins for the biological and medical consequences of microparticle production and for therapeutic strategies to diminish their production and potential to do harm.
Research Division, Puget Sound Blood Center, Seattle, Washington 98104, USA.
Pavel
P
Davizon
Adam D
AD
Munday
José A
JA
López
D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000737:chemistry / Q000648:ultrastructure*; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry*; D013925:Thromboplastin / Q000502:physiology*
D013925:Thromboplastin