The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo.
Department of Pharmacology, University of Leiden, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
P J
PJ
van Bladeren
D D
DD
Breimer
J A
JA
van Huijgevoort
N P
NP
Vermeulen
A
A
van der Gen
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D015946:Ethylene Dibromide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism*; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D008956:Models, Chemical; D015394:Molecular Structure; D010084:Oxidation-Reduction; D051381:Rats
D006842:Hydrocarbons, Brominated; C553859:tetradeutero-1,2-dibromoethane; C031104:N-acetyl-S-(2-hydroxyethyl)cysteine; D015946:Ethylene Dibromide; D005978:Glutathione; C027947:methylene bromide; D000111:Acetylcysteine