Influence of lipoproteins and fibrinogen on pathogenesis of sudden sensorineural hearing loss.
OBJECTIVE
To evaluate the relationship between lipoproteins, fibrinogen and sudden sensorineural hearing loss in a Croatian population. Since pathological derangement of lipoproteins and fibrinogen could be one of the causes of sudden sensorineural hearing loss, we hypothesised that patients with sudden sensorineural hearing loss would have more abnormal fibrinogen and lipoprotein concentrations, compared with subjects with normal hearing.


METHODS
Plasma concentrations of cholesterol, fibrinogen and triglycerides in patients with sudden sensorineural hearing loss were compared with those in a control group (i.e. subjects with normal hearing function).


RESULTS
Patients with sudden sensorineural hearing loss had significantly higher plasma concentrations of cholesterol and low density lipoprotein cholesterol, compared with controls.


CONCLUSIONS
Higher cholesterol and low density lipoprotein cholesterol concentrations were found in patients with sudden sensorineural hearing loss, within a Croatian population. Cholesterol and low density lipoprotein cholesterol concentrations may be important factors in the pathogenesis of sudden sensorineural hearing loss, and should be assessed during the investigation of patients with this condition.
Department of Anesthesiology and Intensive Care, Clinical Hospital Center Zagreb, Zagreb, Croatia.
Z
Z
Oreskovic
D
D
Shejbal
G
G
Bicanic
B
B
Kekic
D000293:Adolescent; D000328:Adult; D000368:Aged; D001299:Audiometry; D016022:Case-Control Studies; D003051:Cochlea / Q000098:blood supply / Q000503:physiopathology; D017523:Croatia / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D005340:Fibrinogen