A systems biology strategy on differential gene expression data discloses some biological features of atrial fibrillation.
Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with extensive structural, contractile, and electrophysiological remodeling. In this manuscript we re-analyzed gene expression data from a microarray experiment on AF patients and control tissues, using a new paradigm based on a posteriori unsupervised strategy in which the discrimination of patients comes out from purely syntactical premises. This paradigm, more adherent to biological reality where genes work in highly connected networks, allowed us to get both a very precise patients/control discrimination and the discovery of cell adhesion/tissue modeling and inflammation processes as the main dimensions of AF.
Department of Technologies and Health, Istituto Superiore di Sanità, Rome, Italy. federica.censi@iss.it
Federica
F
Censi
Giovanni
G
Calcagnini
Pietro
P
Bartolini
Alessandro
A
Giuliani
D001281:Atrial Fibrillation / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D049490:Systems Biology