Visualization and analysis of a cardio vascular disease- and MUPP1-related biological network combining text mining and data warehouse approaches.
Detailed investigation of socially important diseases with modern experimental methods has resulted in the generation of large volume of valuable data. However, analysis and interpretation of this data needs application of efficient computational techniques and systems biology approaches. In particular, the techniques allowing the reconstruction of associative networks of various biological objects and events can be useful. In this publication, the combination of different techniques to create such a network associated with an abstract cell environment is discussed in order to gain insights into the functional as well as spatial interrelationships. It is shown that experimentally gained knowledge enriched with data warehouse content and text mining data can be used for the reconstruction and localization of a cardiovascular disease developing network beginning with MUPP1/MPDZ (multi-PDZ domain protein).
Bio-/Medical Informatics Department, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany. bjoern@CELLmicrocosmos.org
Björn
B
Sommer
Evgeny S
ES
Tiys
Benjamin
B
Kormeier
Klaus
K
Hippe
Sebastian J
SJ
Janowski
Timofey V
TV
Ivanisenko
Anatoly O
AO
Bragin
Patrizio
P
Arrigo
Pavel S
PS
Demenkov
Alexey V
AV
Kochetov
Vladimir A
VA
Ivanisenko
Nikolay A
NA
Kolchanov
Ralf
R
Hofestädt
D002311:Cardiomyopathy, Dilated / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D057225:Data Mining / Q000379:methods; D030562:Databases, Protein; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D016247:Information Storage and Retrieval; D008565:Membrane Proteins; D039781:PubMed; D012984:Software; D049490:Systems Biology; D014584:User-Computer Interface
D002352:Carrier Proteins; C111442:MPDZ protein, human; D008565:Membrane Proteins