Prevalence of high-risk human papillomavirus types 16 and 18 in healthy women with cytologically negative pap smear in Iran.
BACKGROUND
Because human papillomavirus (HPV) is one of the causal factors in cervical cancer, understanding the epidemiology of this infection is an important step towards developing strategies for prevention.


METHODS
We evaluated the prevalence of high-risk human papillomavirus Types 16 and 18 in cervical samples from 402 healthy women with normal Pap smears by testing with type-specific primers in the polymerase chain reaction. Participants were seen at two gynecological clinics affiliated to the Shiraz University of Medical Sciences in Iran.


RESULTS
The prevalence of positive HPV findings was 5.5%; high-risk HPV human papillomavirus Type 16 prevalence was 2% and no patient harbored HPV-18. The prevalence of HPV was 4.5% in younger age group and gradually increased to 20% in the 4 th decade.


CONCLUSIONS
The prevalence of high-risk HPV was highest in the youngest women and gradually decreased with age. Overall, the prevalence of HPV in our population is low.
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
Akbar
A
Safaei
Mahsa
M
Khanlari
Moghdeh
M
Momtahen
Ahmad
A
Monabati
Minoo
M
Robati
Sedigheh
S
Amooei
Behnaz
B
Valibeigi
Negar
N
Azarpira
D000328:Adult; D000367:Age Factors; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology*; D017931:DNA Primers; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014626:Vaginal Smears
D017931:DNA Primers