Cytomegalovirus viruria and DNAemia in healthy seropositive women.
Viruria and DNAemia patterns were investigated in 205 seroimmune women enrolled in a prospective cytomegalovirus (CMV) reinfection study. CMV DNA was detected at least once in urine and blood specimens from 83% and 52% of patients, respectively. At baseline, 39% of patients had viruria, and 24% had DNAemia. Intermittent viruria and viremia was observed throughout the study. There were no differences in baseline CMV positivity by polymerase chain reaction or in longitudinal DNAemia and viruria between the women with and without serological evidence of reinfection. In young seropositive women, CMV DNAemia and viruria are common, which suggests that naturally acquired immunity to CMV does not alter shedding patterns.
Department of Pediatrics, University of Alabama at Birmingham, Alabama 35233, USA.
Nitin
N
Arora
Zdenek
Z
Novak
Karen B
KB
Fowler
Suresh B
SB
Boppana
Shannon A
SA
Ross
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D001769:Blood / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000821:virology*; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D012008:Recurrence; D014556:Urine / Q000821:virology*; D055815:Young Adult
D000914:Antibodies, Viral; D004279:DNA, Viral