BK virus encephalitis with thrombotic microangiopathy in an allogeneic hematopoietic stem cell transplant recipient.
BK virus (BKV) infection occurs most often in immunocompromised hosts, in the setting of renal or bone marrow transplantation. Hemorrhagic cystitis is the commonest manifestation but in recent years infections in other organ systems have been reported. We report an unusual case of biopsy-proven BKV encephalitis in a hematopoietic stem cell transplant patient who subsequently developed thrombotic microangiopathy. As far as we know, this is the first report of such an association in a transplant patient.
Serviço Transplantação Progenitores Hematopoiéticos, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal. ronolosi@gmail.com
R
R
Lopes da Silva
I
I
Ferreira
G
G
Teixeira
D
D
Cordeiro
M
M
Mafra
I
I
Costa
J M
JM
Bravo Marques
M
M
Abecasis
D001739:BK Virus; D018792:Encephalitis, Viral / Q000821:virology*; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000209:etiology / Q000821:virology*; D014412:Tumor Virus Infections / Q000209:etiology / Q000821:virology*