[Viable myocardium detecting by CARTO voltage mapping in swine model of acute myocardial infarction].
OBJECTIVE
To evaluate the accuracy and practicability of detecting viable myocardium by CARTO voltage mapping in swine model of acute myocardial infarction (MI).


METHODS
MI was induced in 13 anesthetized swines via occluding the distal of left anterior descending coronary arteries by angioplasty balloon for 60-90 minutes. The viable myocardium detection by CARTO voltage mapping was made after reconstruction of the left ventricle using CARTO and the results were compared with TTC staining. The standard of CARTO voltage to detect viable myocardium was 0.5 - 1.5 mV while viable myocardium showed pink color by TTC staining.


RESULTS
Eleven out of 13 swines survived the operation and 2 swines died of ventricular fibrillation at 45 and 65 minutes post ischemia. Left ventricle was divided into 16 segments and 176 segments from 11 swines were analyzed. Viable myocardium detected by CARTO voltage mapping was identical as identified by TTC staining (Kappa = 0.816, P < 0.001). Taken the TTC result as standard, the sensitivity, specificity and accuracy rate of CARTO voltage mapping are 71.8%, 96.5% and 90.9% respectively.


CONCLUSIONS
CARTO voltage mapping could be used as a reliable tool to detect viable myocardium in this model.
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Tao
T
Lin
Yi-Tong
YT
Ma
Yi-Ning
YN
Yang
Hu-Yati
HY
Mu
Peng-Yi
PY
He
Yu-Chun
YC
Yang
Ping
P
Chou
Fen
F
Liu
Yan-Yi
YY
Zhang
D000818:Animals; D002470:Cell Survival; D004195:Disease Models, Animal; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D009206:Myocardium / Q000166:cytology*; D013552:Swine