Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease.
OBJECTIVE
In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease.


METHODS
Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24h before and after PCI.


RESULTS
Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P>0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P<0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P>0.05).


CONCLUSIONS
We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values.
Cardiovascular Research Center, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science (MUMS), Mashhad, Iran; Department of Cardiology, Faculty of Medicine, MUMS, Mashhad, Iran.
Homa
H
Falsoleiman
Mashalla
M
Dehghani
Mohsen
M
Moohebati
Afsoon
A
Fazlinezhad
Mahdi Hassanzadeh
MH
Daloee
Daryoush Hamidi
DH
Alamdari
Habib Ollah
HO
Esmaily
Seyyed Mohammad Reza
SM
Parizadeh
Shima
S
Tavallaie
Amir Ali
AA
Rahsepar
Roghayeh
R
Paydar
Seyyed Mohammad Reza
SM
Kazemi-Bajestani
Hossein
H
Pourghadam-Yari
Parisa Abbasi
PA
Parizad
Majid
M
Ghayour-Mobarhan
Gordon A
GA
Ferns
D054855:Drug-Eluting Stents; D006801:Humans; D008670:Metals; D017382:Reactive Oxygen Species; D012307:Risk Factors; D016896:Treatment Outcome
D008670:Metals; D017382:Reactive Oxygen Species