Characterization of sulfhydryl heterogeneity in human serum albumin and recombinant human serum albumin for clinical use.
Since human serum albumin has one sulfhydryl group and 17 disulfides, reactive sulfhydryl groups give rise to heterogeneity. The present paper presents a comparison of sulfhydryl heterogeneity in human serum albumin and recombinant human serum albumin for clinical use. Low molecular weight sulfhydryl compounds were identified from both sources. The recombinant albumin had a much higher sulfhydryl content than plasma serum albumin.
Advanced Medical Research Laboratory, Mitsubishi Tanabe Corp., Osaka, Japan. k.i.1203peace-man@tenor.ocn.ne.jp
Kazuo
K
Ikegaya
Kiyoshi
K
Nokihara
Tadashi
T
Yasuhara
D004220:Disulfides / Q000032:analysis; D006801:Humans; D008970:Molecular Weight; D011994:Recombinant Proteins / Q000737:chemistry* / Q000627:therapeutic use; D012709:Serum Albumin / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000032:analysis*
D004220:Disulfides; D011994:Recombinant Proteins; D012709:Serum Albumin; D013438:Sulfhydryl Compounds