[The expression of p53, cyclin D1 and PCNA in non-small cell lung cancer].
BACKGROUND
To study the expression of p53, cyclin D1 proteins and their relations to cell proliferation in non-small cell lung cancer ( NSCLC) .


METHODS
The expression of p53, cyclin D1 proteins and PCNA was studied in 74 cases of NSCLC and 10 cases of normal lung tissues by SP immunohistochemical technique.


RESULTS
Positive rates of p53 and cyclin D1 protein expression in NSCLC were 55. 41% and 37. 84% respectively, which were both significantly higher than those in normal lung tissues ( P₁ = 0. 003 1, P₂= 0. 042 9) . p53 protein expression correlated remarkably with lymphatic metastasis ( P= 0. 022 2) . p53 and cyclin D1 protein expression correlated significantly with PCNA index respectively ( P₁ = 0. 001 0, P₂ = 0. 000 9) . There was no significant correlation between p53 and cyclin D1 proteins ( P > 0. 05) .


CONCLUSIONS
p53, cyclin D1 protein overexpression plays an important role in tumorigenesis and cell proliferation of NSCLC. p53 is also an important indicator in the diagnosis and prognostic evaluation of NSCLC.
Department of Pathology , TianjinMedical University , Tianjin 300070, P. R. China.
X
X
Wang
Y
Y
Li
H
H
Zhao
T
T
Zhao
N
N
Zhang
Y
Y
Ma
J
J
Yang