[Immunological blood transfusion safety and selection of red blood cells issued from hospital blood banks].
Allogeneic red blood cells transfusion is always an immunological challenge and the choice of the blood products is crucial for the patient safety. But this choice may be hampered by the quality or the quantity of the available supply. In the end, the lack of transfusion may be more harmful than transfusion. The balance between patients' needs and blood centres supplying is always delicate. The conditions are not the same for all blood groups. Things are easier for the KEL1 phenotype, where the supply must ensure only 92.5% of KEL: -1 red blood cells instead of the 91% expected. More complicated is the situation for group O red blood cells with 47 versus 43%. But the major problem concerns RH: -1 red blood cells, for which the needs reach 20.1 versus 15%. These challenges require a lot of efforts from blood centres staffs to influence blood donors' recruitment and appointments. A justified and carefully selected blood products issuing may be of great help, especially for group O RH: -1 red blood cells. Therefore, hospital blood banks must have ad hoc procedures and a trained staff to put them into practice.
EFS Centre Atlantique, site d'Orléans, 14, avenue de l'Hôpital, 45072 Orléans cedex 2, France. jean-yves.py@efs.sante.fr
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D001771:Blood Banks; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000209:etiology / Q000517:prevention & control*; D001788:Blood Grouping and Crossmatching; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000592:standards; D004912:Erythrocytes / Q000276:immunology*; D006301:Health Services Needs and Demand; D006761:Hospitals; D006801:Humans; D007626:Kell Blood-Group System / Q000276:immunology; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D018570:Risk Assessment
D001789:Blood Group Antigens; D007626:Kell Blood-Group System; D012204:Rh-Hr Blood-Group System