Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran.
OBJECTIVE
Paraoxonase (PON) is associated with high-density lipoprotein and protects serum lipid from oxidation. The aim of this study was to determine serum PON, arylesterase (ARE) activities, and total antioxidant capacity (TAC) in metabolic syndrome (MES).


METHODS
This case-control study was performed on 106 patients with MES and 231 healthy subjects. Serum PON and ARE activities were determined spectrophotometrically. TAC was determined using ferric reducing ability of plasma assay.


RESULTS
The results showed that serum PON activity was significantly lower in patients with MES (69.62 ± 59.86  IU/l) than healthy subjects (91.64 ± 77.45 IU/l) (P < 0.05). The serum ARE activity in MES and normal subjects were 45.23 ± 23.24 and 65.69 ± 31.10  kU/l respectively. The ARE activity was significantly lower in patients with MES than normal subjects (P < 0.0001). No significant differences were observed between MES and normal subjects regarding TAC.


CONCLUSIONS
The lower PON and ARE activities in MES may be considered an independent risk factor for cardiovascular disease, which remains to be cleared.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43175, Iran. mhd.hashemi@gmail.com
Mohammad
M
Hashemi
Dor Mohammad
DM
Kordi-Tamandani
Nooshin
N
Sharifi
Abdolkarim
A
Moazeni-Roodi
Mahmoud-Ali
MA
Kaykhaei
Behzad
B
Narouie
Adam
A
Torkmanzehi
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D001786:Blood Glucose; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007492:Iran; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000201:enzymology*; D008875:Middle Aged; D013053:Spectrophotometry
D000975:Antioxidants; D001786:Blood Glucose; D008055:Lipids; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase