[Ewing's sarcoma of bone:treatment results and prognostic factors].
OBJECTIVE
To determine the prognostic factors from the view of clinic and pathology.


METHODS
A retrospective analysis was performed on a data set of 78 patients with Ewing's sarcoma treated at Peking University People's Hospital Musculoskeletal tumor center between July 1998 and July 2007. Five-year overall survival (OS), recurrence rate and prognostic factors were analyzed in this study. Univariate and multivariate analysis were performed to determine the prognostic factors for OS.


RESULTS
Fifty-three cases were followed up, follow-up time ranged from 8.0 to 101.0 months (median 37.6 months). The 5-year overall survival rate and local recurrence rate were 33.7% and 20.8% respectively. Univariate showed age < 20 years, metastases free at diagnosis, tumor located at extremities, tumor size < 10 cm, adequate surgical margin had better survival rate (all P < 0.05). Multivariate analysis demonstrated that metastases at diagnosis, primary site and tumor size were independent prognostic factors for OS.


CONCLUSIONS
The independent prognostic factors Ewing's sarcoma are metastases at diagnosis, primary site, tumor size.
Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing 100044, China.
Jie
J
Zang
Wei
W
Guo
Rong-li
RL
Yang
Xiao-dong
XD
Tang
Tao
T
Ji
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult