Designing polymeric particles for antigen delivery.
By targeting dendritic cells, polymeric carriers in the nano to lower micron range constitute very interesting tools for antigen delivery. In this critical review, we review how new immunological insights can be exploited to design new carriers allowing one to tune immune responses and to further increase vaccine potency (137 references).
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium.
Stefaan
S
De Koker
Bart N
BN
Lambrecht
Monique A
MA
Willart
Yvette
Y
van Kooyk
Johan
J
Grooten
Chris
C
Vervaet
Jean Paul
JP
Remon
Bruno G
BG
De Geest
D000941:Antigens / Q000008:administration & dosage* / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry*; D014612:Vaccines / Q000276:immunology
D000941:Antigens; D004337:Drug Carriers; D011108:Polymers; D014612:Vaccines