Successful Treatment of ANCA-Negative Wegener's Granulomatosis with Rituximab.
Wegener's Granulomatosis (WG) is a systemic vasculitis typically associated with antineutrophil cytoplasmic antibodies (ANCAs). A small proportion of patients are ANCA negative, however, and this is more commonly found in individuals with disease limited to the ears, nose, throat, and lungs, who do not have renal involvement. Rituximab is a monoclonal anti-CD20 antibody that has been demonstrated to be effective in the treatment of autoantibody-associated rheumatic diseases, including systemic WG. We report the case of a patient with ANCA-negative WG who responded well to rituximab, illustrating that even in the absence of detectable autoantibodies, B-cell depletion can be effective.
Department of Rheumatology, York Hospital, Wigginton Road, York YO31 8HE, UK.
Afsha
A
Khan
Catherine A
CA
Lawson
Mark A
MA
Quinn
Amanda H
AH
Isdale
Michael J
MJ
Green