[Application of timolol in preventing variceal hemorrhage in patients with portal hypertension].
OBJECTIVE
To determine the effectiveness of timolol in preventing first variceal hemorrhage in portal hypertensive patients with esophageal varices.


METHODS
A total of 42 cirrhotic patients with esophageal varices were enrolled in this study and received timolol or band ligation therapy randomly,with 21 patients in each group. The diameters of portal vein (PV), superior mesenteric vein (SMV), and splenic vein (SPV) as well as the portal venous flow and the splenic venous flow were measured. The first esophageal variceal bleeding of the two groups was recorded.


RESULTS
The diameters of PV, SMV, and SPV as well as the flow of PV and SPV showed no significant difference before and after treatment in band ligation group (P>0.05). In timolol group,however,the diameter of portal vein significantly decreased after treatment [(14.11±2.96) mm vs. (12.15±1.61)mm, P<0.05], and the average blood flow of portal vein also significantly decreased after treatment [(1277.33±495.19) ml/min vs. (719.17±245.16)ml/min, P<0.05]. Both timolol and band ligation effectively prevented esophageal variceal bleeding, and the risk of first esophageal variceal bleeding in these two groups were not significantly different (15% vs. 10%, P<0.05).


CONCLUSIONS
Timolol is safe and effective in preventing the first variceal bleeding in portal hypertensive patients with esophageal varices.
Department of General Surgery, the Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China. doctor68@sohu.com
Zhong-hua
ZH
Shang
Hai-yun
HY
Chen
Hong-lin
HL
Dong
D000328:Adult; D000368:Aged; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D008026:Ligation; D008297:Male; D008875:Middle Aged; D013999:Timolol / Q000627:therapeutic use*; D055815:Young Adult
D013999:Timolol