Effect of randomly interesterified triacylglycerol containing medium- and long-chain fatty acids on hepatic fatty acid oxidation after a single administration to rats.
MLCTs, which are randomly interesterified triacylglycerol containing medium- and long-chain fatty acids in the same glycerol molecule, showed significantly higher acyl-CoA dehydrogenase activity when measured by using butyryl-CoA, octanoyl-CoA, and palmitoyl-CoA as substrates than long-chain triacylglycerol one hour after a single administration to rats. These results suggest that not only medium-chain fatty acid oxidation, but also long-chain fatty acid oxidation were increased in the liver of rats administered with MLCT.
Central Research Laboratory, The Nisshin OilliO Group, Ltd., Yokosuka, Kanagawa, Japan. h-shinohara@nisshin-oillio.com
Hisami
H
Shinohara
Jian
J
Wu
Toshiaki
T
Aoyama
D042964:Acyl-CoA Dehydrogenase; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D014280:Triglycerides / Q000494:pharmacology*
D005227:Fatty Acids; D014280:Triglycerides; D042964:Acyl-CoA Dehydrogenase