Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer.
Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.
Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi-do 461-701, Korea.
Dong Kee
DK
Yi
In-Cheol
IC
Sun
Ju Hee
JH
Ryu
Heebeom
H
Koo
Chul Wan
CW
Park
In-Chan
IC
Youn
Kuiwon
K
Choi
Ick Chan
IC
Kwon
Kwangmeyung
K
Kim
Cheol-Hee
CH
Ahn
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging / Q000379:methods*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005453:Fluorescence; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006358:Hot Temperature; D053685:Laser Therapy / Q000379:methods*; D008027:Light; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry; D009368:Neoplasm Transplantation; D010789:Phototherapy / Q000379:methods*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000628:therapy; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared; D013696:Temperature
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D006046:Gold; D020782:Matrix Metalloproteinases