Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease.
We tested the hypothesis that levels of CSF biomarkers associated with dementia and cognitive impairment are correlated with cognitive performance in non-demented Parkinson's disease (PD) patients. Twenty-two non-demented patients with PD underwent neuropsychological testing and lumbar puncture to collect CSF. We correlated performance scores on the Logical Memory (delayed), Category Fluency, Digit Symbol, and Trails B minus A with CSF concentrations of amyloid (A) β(42), total tau (t-tau), Aβ(42)/t-tau, and Brain Derived Neurotrophic Factor (BDNF). We observed significant associations between performance on the Digit Symbol test and CSF levels of Aβ(42), Aβ(42)/t-tau, and BDNF, and between performance on the Category Fluency (vegetable) and Aβ(42)/t-tau. While several of these associations were attenuated by adjusting for age, our results suggest that it may be possible to use CSF biomarkers to characterize pathophysiologic processes underlying even mild cognitive deficits in non-demented PD patients.
Mental Illness Research, Education, and Clinical Center of Veterans Administration, Seattle, WA, USA.
James B
JB
Leverenz
G Stennis
GS
Watson
Jane
J
Shofer
Cyrus P
CP
Zabetian
Jing
J
Zhang
Thomas J
TJ
Montine
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000523:psychology*; D011597:Psychomotor Performance / Q000502:physiology; D016875:tau Proteins / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016875:tau Proteins