Desquamative inflammatory vaginitis as a manifestation of vitamin D deficiency associated with Crohn disease: case reports and review of the literature.
Desquamative inflammatory vaginitis (DIV) is a chronic disorder associated with yellow vaginal discharge, vulvovaginal burning and pruritus, and dyspareunia. The cause of DIV is unknown; however, infectious, hormonal, and inflammatory etiologies have been proposed. In this series, we observe the association of DIV and vitamin D deficiency by reporting 4 cases of women with DIV and vitamin D deficiency associated with Crohn disease. We further show that the DIV symptoms resolve when the circulating concentrations of 25-hydroxyvitamin D (25-HD) returned to normal. These data provide further support for the notion that DIV can be associated with vitamin D deficiency and DIV symptoms reflect altered vaginal mucous membrane function.
VA New York Harbor Healthcare System, New York Campus, New York, USA.
Monica
M
Peacocke
Erin
E
Djurkinak
Hui C
HC
Tsou
Susan
S
Thys-Jacobs
D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D009092:Mucous Membrane / Q000473:pathology; D014627:Vaginitis / Q000209:etiology* / Q000503:physiopathology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000209:etiology
D014807:Vitamin D; C104450:25-hydroxyvitamin D