"Skulls and bones" new member: Th17.
Osteolytic bone disease mediated by osteoclasts occurs adjacent to myeloma cells suggesting a tight interrelationship between these cells and their microenvironment. In this issue of Blood, Noonan and colleagues(1) challenge this current paradigm by invoking a role for a subpopulation of T cells known as T-helper 17 (Th17) as a key regulator of bone disease in myeloma.
Moffitt Cancer Center & Research Institute.
Eduardo M
EM
Sotomayor