[IgG4-related Mikulicz's disease: a report of 3 cases].
BACKGROUND
We report three cases of hyper-IgG4 disease with synchronous or asynchronous lymphocytic infiltration onset, IgG4 positive plasma cell infiltration, and fibril formation in multiple exocrine glands and extranodal organs. IgG4-related sialadenitis attracting recent attention has yet to be clarified as a clinical entity.


METHODS
Case 1, a 61-year-old man, had a submandibular gland sample showing IgG4-positive plasma cell infiltration. Case 2, a 61-year-old man, was diagnosed with IgG4-related Mikulicz's disease confirmed by a sublingual gland sample. Case 3, a 57-year-old woman, had a diagnosis of IgG4-related Mikulicz's disease confirmed based on labial and sublingual gland samples. All reported oral dryness and bilateral submandibular swelling. Cases 1 and 2 recovered following Predonine administration tapered from 30 or 20 mg.


CONCLUSIONS
IgG4-related Mikulicz's disease must be recognized as a clinical entity, together with its diagnostic criteria and treatment. Sublingual gland biopsy should be done to confirm its diagnosis following sublingual gland swelling.
Department of Otolaryngology, Saitama Medical University, Saitama.
Hiroto
H
Nakada
Osamu
O
Shibasaki
Masato
M
Nakashima
Hiroyoshi
H
Yoshinami
Yasuhiro
Y
Kase
D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D008882:Mikulicz' Disease / Q000276:immunology / Q000473:pathology; D013361:Sublingual Gland / Q000473:pathology
D007074:Immunoglobulin G