[Relationship between the colonization of Group B Streptococci, Mycoplasma, and Chlamydia trachomatis infections and spontaneous abortion due to early embryonic death].
OBJECTIVE
To explore the relationship between the colonization of group B streptococci (GBS), mycoplasma,and Chlamydia trachomatis (CT) infections and spontaneous abortion due to early embryonic death.


METHODS
Totally 74 patients (study group) who experienced the missed abortion during their first or second trimester and 62 women (control group) who underwent induced termination of normal pregnancy during the first or second trimester were enrolled in this study. The vaginal secretions, intrauterine aspirates, and amniotic fluids were collected for GBS culture. Cervical mycoplasma (UU+MH) and CT were detected at the same time.


RESULTS
Positive results of GBS culture of vaginal secretions were detected in 9 patients (12.16%) in the study group, but in only 6 patients (9.68%) in control group (P=0.662). The intrauterine aspirate samples (as well as the amniotic fluid samples) of all cases were negative in GBS culture. The positive rates of UU and MH were 32.43% (24/74) and 16.22% (12/74) in the study group, but were only 10.35% (12/62) (P=0.0103) and 6.45 (4/62) (P=0.042) in the control group. The positive rate of CT was 8.11% (6/74) in the study group and 8.06 % (5/62) in the control group (P=0.905). The rate of concurrent infection of GBS and mycoplasma was 4.05% (3/74) in the study group and 6.45% (4/62) in the control group (P=0.743). The rate of concurrent infection of GBS and CT was 0 in the study group and 1.61% (1/62) in the control group (P=0.475). The rate of concurrent mycoplasma and CT infection was 2.70% (2/74) in the study group and 0 in the control group (P=0.325). Furthermore, no one was positive for poly infection of all these three pathogens.


CONCLUSIONS
GBS may be positive in the genital tract of some pregnant women but is not related with early abortion. The mycoplasma infection may be one of the reasons leading to arrested intrauterine pregnancy.
Department of Obstetrics and Gynecology, Shenzhen Shajing Affiliated Hospital, Guangzhou Medical University, Shenzhen, Guangdong 518104, China.
Yong-hong
YH
Li
Qin-lan
QL
Wu
Yi-mei
YM
Zou
Wei-fang
WF
Pan
Dan
D
Peng
Xin-yan
XY
Liu
D000022:Abortion, Spontaneous / Q000382:microbiology*; D000328:Adult; D002584:Cervix Uteri / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D009174:Mycoplasma / Q000302:isolation & purification*; D011247:Pregnancy; D013292:Streptococcus agalactiae / Q000302:isolation & purification*; D055815:Young Adult