Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration.
Two cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives were synthesized as antioxidants against light-induced retinal degeneration. Whereas nitrone 10 significantly protected retina against bright fluorescent light exposure when injected into the vitreous at 1 mM, no protection was observed with nitrone 6. The parent compound α-phenyl-N-tert-butyl nitrone also exhibited protective activity at 9 mM but not at 1 mM. This suggests that nitrone 10 may be a candidate for the treatment of retinal diseases.
Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Université d'Avignon et des Pays de Vaucluse, Faculté des Sciences, Avignon, France.
Fanny
F
Choteau
Grégory
G
Durand
Isabelle
I
Ranchon-Cole
Christine
C
Cercy
Bernard
B
Pucci
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004187:Disaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D008027:Light; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012162:Retinal Degeneration / Q000517:prevention & control*; D012164:Retinal Diseases / Q000188:drug therapy
D000975:Antioxidants; D003497:Cyclic N-Oxides; D004187:Disaccharides; D007097:Imines; D017382:Reactive Oxygen Species; C029217:phenyl-N-tert-butylnitrone; D002784:Cholesterol