Cortical layer V neurons in the auditory and visual cortices of normal, reeler, and yotari mice.
Both in the Reelin-deficient reeler and Dab1-deficient yotari mice, layer V corticospinal tract neurons in the sensory-motor cortex are radially spread instead of being confined to a single cortical layer. In the present study, we examined distribution pattern of cortical layer V neurons in the visual and auditory cortices of reeler and yotari mice with the injection of HRP into the superior and inferior colliculi of the adult animals, respectively. After the injection of HRP into the superior colliculus of the normal mouse, retrogradely labeled cells were distributed in layer V of the visual cortex, while the similar injection of HRP in the reeler and yotari mice produced radial dispersion of retrograde labeling through all of the depths of the visual cortex of these mutant mice. Next, we injected HRP into the inferior colliculus of the normal, reeler and yotari mice. Retrogradely labeled neurons were distributed in layer V of the normal auditory cortex, whereas they were again radially scattered in the auditory cortex of the reeler and yotari mice. Taken together with the previous and present findings, layer V cortical efferent neurons are radially scattered in the sensory-motor, visual and auditory cortices of the reeler and yotari mice.
Division of Psychiatry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Yasuo
Y
Yoshihara
Tomiyoshi
T
Setsu
Yu
Y
Katsuyama
Satoshi
S
Kikkawa
Toshio
T
Terashima
Kiyoshi
K
Maeda
D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000201:enzymology / Q000473:pathology*; D015816:Cell Adhesion Molecules, Neuronal / Q000172:deficiency / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000172:deficiency / Q000235:genetics; D006735:Horseradish Peroxidase / Q000008:administration & dosage / Q000493:pharmacokinetics; D051379:Mice; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics; D009474:Neurons / Q000166:cytology / Q000201:enzymology / Q000473:pathology; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000172:deficiency / Q000235:genetics; D014018:Tissue Distribution; D014793:Visual Cortex / Q000166:cytology / Q000201:enzymology / Q000473:pathology*
D015816:Cell Adhesion Molecules, Neuronal; C103773:Dab1 protein, mouse; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D006735:Horseradish Peroxidase; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases