Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group.
Recent advances in genomics, proteomics, and biotechnology have provided unprecedented opportunities for translational research and personalized medicine. Human biospecimens and biofluids represent an important resource from which molecular data can be generated to detect and classify injury and to identify molecular mechanisms and therapeutic targets. To date, there has been considerable variability in biospecimen and biofluid collection, storage, and processing in traumatic brain injury (TBI) studies. To realize the full potential of this important resource, standardization and adoption of best practice guidelines are required to insure the quality and consistency of these specimens. The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations for core data elements for TBI research and develop best practice guidelines to standardize the quality and accessibility of these specimens. Consensus recommendations were developed through interactions with focus groups and input from stakeholders participating in the interagency workshop on Standardization of Data Collection in TBI and Psychological Health held in Washington, DC, in March 2009. With the adoption of these standards and best practices, future investigators will be able to obtain data across multiple studies with reduced costs and effort and accelerate the progress of genomic, proteomic, and metabolomic research in TBI.
University of California San Francisco, CA 94110, USA. manleyg@neurosurg.ucsf.edu
Geoffrey T
GT
Manley
Ramon
R
Diaz-Arrastia
Mary
M
Brophy
Doortje
D
Engel
Clay
C
Goodman
Katrina
K
Gwinn
Timothy D
TD
Veenstra
Geoffrey
G
Ling
Andrew K
AK
Ottens
Frank
F
Tortella
Ronald L
RL
Hayes
D015415:Biomarkers / Q000032:analysis*; D001706:Biopsy / Q000706:statistics & numerical data*; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001930:Brain Injuries / Q000175:diagnosis*; D003625:Data Collection / Q000379:methods*; D006801:Humans; D017410:Practice Guidelines as Topic
D015415:Biomarkers