Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen.
Enzyme-catalyzed polycondensation for the synthesis of polyester prodrugs of ketoprofen was reported. Lipase acrylic resin from Candida antarctica (CAL-B) was used to synthesize the linear polyesters with pendent ketoprofen groups based on ketoprofen glycerol ester, poly(ethylene glycol), and divinyl sebacate. The products were characterized by GPC and (1)H NMR. The results indicated that the molecular weight and yields of the polyesters depend on experimental conditions such as temperature and feed ratio. The in vitro study showed that the drug release from the polyester was slow under physiological conditions, which indicated that the polyester could be a promising prodrug with extended pharmacological effects by delayed release of ketoprofen.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
Hai-Yang
HY
Wang
Wei-Wei
WW
Zhang
Na
N
Wang
Chao
C
Li
Kun
K
Li
Xiao-Qi
XQ
Yu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055162:Biocatalysis; D002175:Candida / Q000201:enzymology; D007660:Ketoprofen / Q000737:chemistry*; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis*; D011355:Prodrugs / Q000138:chemical synthesis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011091:Polyesters; D011355:Prodrugs; D007660:Ketoprofen