Synthesis and antiviral activity of new indole-based heterocycles.
New 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine and 1,3-thiazole derivatives incorporating indole nucleus were prepared using 3-acetylindole as precursor and evaluated for their antiviral activity against herpes simplex type 1 (HSV-1).
Applied Organic Chemistry Department, National Research Centre, Egypt. abdelgawadhassan@hotmail.com
Hassan
H
Abdel-Gawad
Hanan Ahmed
HA
Mohamed
Kamal Mohamed
KM
Dawood
Farid Abdel-Rahem
FA
Badria
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells
D000998:Antiviral Agents; D006571:Heterocyclic Compounds; D007211:Indoles; D013844:Thiazoles; C531932:3-acetylindole