Comparing gray mineral trioxide aggregate and diluted formocresol in pulpotomized human primary molars.
OBJECTIVE
The purpose of this multisite, multioperator, prospective, randomized, controlled clinical trial was to evaluate the 6-month outcomes of diluted formocresol (DFC) compared to gray mineral trioxide aggregate (GMTA) as pulpotomy medicament.


METHODS
Determined by a power analysis, 252 molars of 152 children were recruited. The teeth were randomly assigned to receive GMTA or DFC. At the 6-month follow-up, 118 children with 203 treated teeth were evaluated.


RESULTS
Four blinded and calibrated evaluators scored each radiograph for pathologies. Clinical success was similar for DFC (97%) and GMTA (100%), (P<.09). Radiographic success differed significantly (P<.04) for DFC (86%) and GMTA (95%). Pulp canal obliteration was radiographically observed in 25% of the DFC group and in 37% of the GMTA group (P=.07). Dentin bridging was observed in 22% of the GMTA group but was not found in the DFC group (P<.01).


CONCLUSIONS
Teeth treated with GMTA showed more favorable radiographic outcomes than DFC at 6 months post-treatment.
The Center for Pediatric Dentistry, Calgary, Alberta, Canada.
Cameron M
CM
Zealand
Daniel M
DM
Briskie
Tatiana M
TM
Botero
James R
JR
Boynton
Jan C C
JC
Hu
D017607:Aluminum Compounds / Q000627:therapeutic use; D017610:Calcium Compounds / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003809:Dentin, Secondary / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D005566:Formocresols / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008963:Molar; D010087:Oxides / Q000627:therapeutic use; D011446:Prospective Studies; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011672:Pulpotomy / Q000379:methods*; D017640:Silicates / Q000627:therapeutic use; D016037:Single-Blind Method; D014094:Tooth, Deciduous
D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D005566:Formocresols; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D017640:Silicates; C086631:mineral trioxide aggregate; C031025:formocresol