Population-based study of ovarian cancer in Côte d'Or: prognostic factors and trends in relative survival rates over the last 20 years.
BACKGROUND
The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005.


METHODS
Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS was estimated using a generalized linear model with a Poisson error structure. Relative survival and its 95% confidence interval (CI) were described at the following specific time points 1, 3 and 5 years. The effect of prognostic factors on survival was assessed with multivariate analyses of RS.


RESULTS
The median follow-up was 12 years. The RS rates at 1, 3 and 5 years were 81%, 55% and 44%, respectively. As compared with the period 1982-1989, an improvement in survival was found for the period 1998-2005: HR = 0.52[0.40-0.67]. Women who lived in urban areas had better RS: HR = 0.82[0.67-0.99]. Patients with epithelial types of ovarian cancer other than mucinous or endometrioid cancer had worse RS than those with serous histology. Age ≥ 70 years was associated with lower survival.


CONCLUSIONS
Period of diagnosis, stage at diagnosis, histology, place of residence and age were independent prognostic factors for survival in ovarian cancer. An improvement in the survival rate was observed after 1998 but a significant improvement was limited to advanced stage cancers.
Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or, Centre Georges François Leclerc, Dijon, France.
Zeinab
Z
Hamidou
Sylvain
S
Causeret
Tienhan S
TS
Dabakuyo
Julie
J
Gentil
Laurent
L
Arnould
Patrick
P
Roignot
Thierry
T
Altwegg
Marie-Laure
ML
Poillot
Franck
F
Bonnetain
Patrick
P
Arveux
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005602:France; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality*; D011379:Prognosis; D012042:Registries; D015996:Survival Rate; D016896:Treatment Outcome