ASD: a comprehensive database of allosteric proteins and modulators.
Allostery is the most direct, rapid and efficient way of regulating protein function, ranging from the control of metabolic mechanisms to signal-transduction pathways. However, an enormous amount of unsystematic allostery information has deterred scientists who could benefit from this field. Here, we present the AlloSteric Database (ASD), the first online database that provides a central resource for the display, search and analysis of structure, function and related annotation for allosteric molecules. Currently, ASD contains 336 allosteric proteins from 101 species and 8095 modulators in three categories (activators, inhibitors and regulators). Proteins are annotated with a detailed description of allostery, biological process and related diseases, and modulators with binding affinity, physicochemical properties and therapeutic area. Integrating the information of allosteric proteins in ASD should allow for the identification of specific allosteric sites of a given subtype among proteins of the same family that can potentially serve as ideal targets for experimental validation. In addition, modulators curated in ASD can be used to investigate potent allosteric targets for the query compound, and also help chemists to implement structure modifications for novel allosteric drug design. Therefore, ASD could be a platform and a starting point for biologists and medicinal chemists for furthering allosteric research. ASD is freely available at http://mdl.shsmu.edu.cn/ASD/.
The Department of Pathophysiology, Chemical Biology Division, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Universities E-Institutes, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Zhimin
Z
Huang
Liang
L
Zhu
Yan
Y
Cao
Geng
G
Wu
Xinyi
X
Liu
Yingyi
Y
Chen
Qi
Q
Wang
Ting
T
Shi
Yaxue
Y
Zhao
Yuefei
Y
Wang
Weihua
W
Li
Yixue
Y
Li
Haifeng
H
Chen
Guoqiang
G
Chen
Jian
J
Zhang
D000494:Allosteric Regulation; D000495:Allosteric Site; D030562:Databases, Protein; D015195:Drug Design; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D014584:User-Computer Interface
D011506:Proteins