Degeneration and repair in central nervous system disease.
Divergent disease triggers in neurodegeneration may induce convergent endogenous pathways in neuronal, glial and vascular elements as the central nervous system (CNS) attempts to compensate, remodel and recover. Dissecting these multicellular mechanisms and the integrative responses in cerebral blood flow and metabolism may allow us to understand the balance between injury and repair, validate new targets and define therapeutic time windows for neurodegeneration.
Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
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D000818:Animals; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000473:pathology*; D003299:Cooperative Behavior; D006801:Humans; D009410:Nerve Degeneration / Q000473:pathology*; D012307:Risk Factors; D014945:Wound Healing