No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders.
BACKGROUND
Genetic factors likely contribute to the biological vulnerability of eating disorders.


OBJECTIVE
Case-control association study on one neuropeptide Y gene (Leu7Pro) polymorphism and three ghrelin gene (Arg51Gln, Leu72Met and Gln90Leu) polymorphisms.


METHODS
114 eating disorder patients (46 with anorexia nervosa, 30 with bulimia nervosa, 38 with binge eating disorder) and 164 healthy controls were genotyped.


RESULTS
No differences were detected between patients and controls for any of the four polymorphisms in allele frequency and genotype distribution (P > 0.05). Allele frequencies and genotypes had no significant influence on body mass index (P > 0.05) in eating disorder patients.


CONCLUSIONS
Positive findings of former case-control studies of associations between ghrelin gene polymorphisms and eating disorders could not be replicated. Neuropeptide Y gene polymorphisms have not been investigated in eating disorders before.
Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University Vienna, Vienna, Austria.
Jochen
J
Kindler
Ursula
U
Bailer
Martina
M
de Zwaan
Karoline
K
Fuchs
Friedrich
F
Leisch
Bettina
B
Grün
Alexandra
A
Strnad
Mirjana
M
Stojanovic
Julia
J
Windisch
Claudia
C
Lennkh-Wolfsberg
Nadja
N
El-Giamal
Werner
W
Sieghart
Siegfried
S
Kasper
Harald
H
Aschauer
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000235:genetics; D056912:Binge-Eating Disorder / Q000235:genetics; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000235:genetics; D016022:Case-Control Studies; D001068:Feeding and Eating Disorders / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D054439:Ghrelin / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
D054439:Ghrelin; D009478:Neuropeptide Y