[Quadratic-orthogonal-rotation-combination design for optimization of ethanol extraction craft from Radix Paeoniae Rubra].
OBJECTIVE
To optimize the ethanol extraction process of Radix Paeoniae Rubra (RPR) using quadratic-orthogonal-rotation-combination design.


METHODS
The influential factors were ethanol volume, ethanol concentration and extracting time. The evaluating indicator was the extraction rate of peoniflorin. The quadratic-orthogonal-rotation-combination design was used to optimize the process and the prediction was carried out.


RESULTS
The optimum conditions of extraction were 73% ethanol, 100 min for extraction, volume of ethanol was 8. 3 times.


CONCLUSIONS
It shows that the optimum model is simple and highly predictive.
Gansu college of Traditional Chinese Medicine, Lanzhou 730000, China. pengxiaoxia@gszy.edu.cn
Xiao-Xia
XX
Peng
Zhen-Wei
ZW
Zhang
D001565:Benzoates / Q000032:analysis / Q000302:isolation & purification*; D001952:Bridged-Ring Compounds / Q000032:analysis / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000431:Ethanol / Q000008:administration & dosage / Q000737:chemistry*; D005960:Glucosides / Q000032:analysis / Q000302:isolation & purification*; D008962:Models, Theoretical; D039821:Monoterpenes; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D012044:Regression Analysis; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D004365:Drugs, Chinese Herbal; D000431:Ethanol; D005960:Glucosides; D039821:Monoterpenes; C015423:peoniflorin; D006027:Glycosides