Emergence of erythromycin- and clindamycin-resistant Streptococcus pyogenes emm 90 strains in Hawaii.
We identified 12 erythromycin- and clindamycin-resistant emm 90 group A streptococcus (GAS) isolates during a retrospective invasive disease survey in Hawaii. A comparison with 20 type-matched isolates showed all resistant isolates to be emm 90.4b with the constitutive or inducible macrolide-lincosamide-streptogramin B resistance phenotype (cMLS(B) or iMLS(B)). All isolates had the same pulsed-field gel electrophoresis (PFGE) pattern, suggesting clonal spread.
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, Honolulu, Hawaii 96826, USA.
Iris
I
Chen
Pakieli
P
Kaufisi
Guliz
G
Erdem
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D002981:Clindamycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial; D005838:Genotype; D006254:Hawaii; D006801:Humans; D058889:Molecular Typing; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D025381:Streptogramin B / Q000494:pharmacology; D015533:Transcriptional Activation
D000900:Anti-Bacterial Agents; D025381:Streptogramin B; D002981:Clindamycin; D004917:Erythromycin