The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics.
Next-generation sequencing is revolutionizing the way in which genomic-scale biological research is performed, and its effects are beginning to be translated medically. Large-scale international collaborations for the comprehensive sequencing of the genome, epigenome, and transcriptomes of cancers and corresponding 'normal' (germ-line) DNA are heralding the start of personalized medical genomics. The promise of eliminating conjecture when determining treatment approaches is certainly appealing for both patients and clinicians; however, several major issues must be resolved before next-generation sequencing will be adopted as a routine clinical tool for patients. This feature review explores the clinical potential and challenges of studying cancer genomes for personalized medical genomics.
The University of Queensland, Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, 306 Carmody Road, St Lucia, QLD 4072, Australia. n.cloonan@uq.edu.au
Nicole
N
Cloonan
Nic
N
Waddell
Sean M
SM
Grimmond
D057890:Epigenomics / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods; D023281:Genomics / Q000379:methods*; D006801:Humans; D007391:International Cooperation; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods