Usefulness and limitations of 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy.
OBJECTIVE
We previously reported in a small series of patients that (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) scintigraphy tested positive in transthyretin-related (TTR) (both mutant and wild-type) but not in primary (AL) amyloidotic cardiomyopathy (AC). We extended our study to a larger cohort of patients with AC.


METHODS
We evaluated (1) 45 patients with TTR-related AC (28 mutant and 17 wild-type), (2) 34 with AL-related AC and (3) 15 non-affected controls. Myocardial uptake of (99m)Tc-DPD (740 MBq i.v.) was semiquantitatively and visually assessed at 5 min and at 3 h.


RESULTS
Heart retention (HR) and heart to whole-body retention ratio (H/WB) of late (99m)Tc-DPD uptake were higher among TTR-related AC (HR 7.8%; H/WB 10.4) compared with both unaffected controls (HR 3.5%; H/WB 5.7; p < 0.0001) and AL-related AC (HR 4.0%; H/WB 6.1; p < 0.0001). For the diagnosis of TTR-related AC, positive and negative predictive accuracy of visual scoring of cardiac retention were: 80 and 100% (visual score ≥1); 88 and 100% (visual score ≥2); and 100 and 68% (visual score = 3). At adjusted linear regression analysis, TTR aetiology turned out to be the only positive predictor of increasing (99m)Tc-DPD uptake in terms of both HR [β 2.5, 95% confidence interval (CI) 1.5-3.5; p < 0.0001] and H/WB (β 3.5, 95% CI 2.1-4.9; p < 0.0001).


CONCLUSIONS
While (99m)Tc-DPD scintigraphy was confirmed to be useful for differentiating TTR from AL-related AC, diagnostic accuracy was lower than previously reported due to a mild degree of tracer uptake in about one third of AL patients. (99m)Tc-DPD scintigraphy can provide an accurate differential diagnosis in cases of absent or intense uptake evaluated by visual score.
Institute of Cardiology, University of Bologna and Policlinico S. Orsola-Malpighi Hospital, Bologna, Italy. claudio.rapezzi@unibo.it
Claudio
C
Rapezzi
Candida Cristina
CC
Quarta
Pier Luigi
PL
Guidalotti
Simone
S
Longhi
Cinzia
C
Pettinato
Ornella
O
Leone
Alessandra
A
Ferlini
Fabrizio
F
Salvi
Pamela
P
Gallo
Christian
C
Gagliardi
Angelo
A
Branzi
D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D001692:Biological Transport; D009202:Cardiomyopathies / Q000150:complications* / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D003937:Diagnosis, Differential; D004164:Diphosphonates / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015609:Organotechnetium Compounds / Q000378:metabolism; D011228:Prealbumin / Q000378:metabolism; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging
D004164:Diphosphonates; D015609:Organotechnetium Compounds; D011228:Prealbumin; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid