[Toxic plasma concentration of clozapine in inflammatory processes].
Clozapine has a narrow therapeutic range. The threshold value for plasma concentrations is 350 μg/l. If plasma concentrations exceed that value, serious side-effects can occur. An increase in plasma concentrations can occur as a result of inflammatory processes which may or may not be caused by an infection. Two cases are discussed in which the plasma concentration of clozapine increased as a result of an inflammatory reaction and signs of intoxication were observed. These developments seemed to be due to cholecystitis and bacterial pneumonia respectively. The clinical presentation and pathophysiology are discussed in relation to inflammatory processes.
Yulius Geestelijke Gezondheid te Dordrecht en verbonden aan de afdeling Psychiatrie van het Erasmus MC te Rotterdam. A.vanGool@yulius.nl
A R
AR
van Gool
M H
MH
de Jong
W M A
WM
Verhoeven
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D002764:Cholecystitis / Q000097:blood*; D003024:Clozapine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D016903:Drug Monitoring; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy
D014150:Antipsychotic Agents; D003024:Clozapine