[Measures of local non-specific resistance during of colon dysbiosis].
OBJECTIVE
To study several parameters of local non-specific resistance during development of experimental dysbiosis caused by administration of wide spectrum antibiotic.


METHODS
Objects of the study were colonocytes and coprofiltrates from 120 outbred mice developing experimental dysbiosis, in which activity of antioxidant enzymes (superoxid dismutase [SOD] and catalase) and level of one of the final product of lipid peroxidation--malondialdehyde (MDA).


RESULTS
Decrease of SOD and catalase activity and significant increase of MDA level during development of experimental dysbiosis were established, which were associated with decreased activity of oxygen-dependent bactericidal systems of colonocytes and changes in composition of colon microbiocenosis.


CONCLUSIONS
It was suggested that changes in parameters of local non-specific resistance could be one of mechanisms, which cause alteration of microbiocenosis composition during colon dysbiosis.
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Gapon
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Ternovskaia
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002374:Catalase / Q000378:metabolism*; D003106:Colon / Q000201:enzymology* / Q000382:microbiology*; D007410:Intestinal Diseases / Q000201:enzymology* / Q000382:microbiology*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase