Effect of drugs on renal development.
Many nephrotoxic effects of drugs have been described, whereas the effect on renal development has received less attention. Nephrogenesis ceases at approximately 36 weeks of gestation, indicating that drugs administered to pregnant women and to preterm-born neonates may influence kidney development. Such an effect on renal development may lead to a wide spectrum of renal malformations (congenital anomalies of the kidney and urinary tract [CAKUT]), ranging from renal agenesis to a reduced nephron number. Any of these anomalies may have long-term sequelae, and CAKUT is the primary cause for renal replacement therapy in childhood. This review focuses on research into the effect of drug treatment during active nephrogenesis during pregnancy and in preterm-born infants. Because the effects of many widely used drugs have not been unraveled thus far, more research is needed to study the effect on renal development and long-term renal sequelae after drug treatment during nephrogenesis.
Department of Pediatric Nephrology, 804, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. m.schreuder@cukz.umcn.nl
Michiel F
MF
Schreuder
Ruud R
RR
Bueters
Marleen C
MC
Huigen
Frans G M
FG
Russel
Rosalinde
R
Masereeuw
Lambertus P
LP
van den Heuvel
D000818:Animals; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects* / Q000196:embryology*; D011247:Pregnancy; D012084:Renin-Angiotensin System / Q000502:physiology; D014551:Urinary Tract / Q000002:abnormalities