[Solid-cystic supratentorial hemangioblastoma affecting the falx cerebri. Report of a case].
BACKGROUND
hemangioblastomas are benign neoplasias that are originated in the central nervous system and constitute between 1.5-2.5% of intracranial tumors. The majority of them are infratentorial, mainly affecting the cerebellum (76%). Supratentorial lessions are rare, being in these cases the frontal, parietal or temporal lobes the most common locations. Meningeal involvement is infrequent. Only eight cases have been reported in the literature. In 30% of the cases, these tumors are associated with von Hippel Lindau syndrome (VHL).


METHODS
67 year old woman without any medical or family history. She presented with 4 month evolution neurological symptoms. The cranial MRI scan showed a solitary solid-cystic lesion on the right paramedian frontal lobe, in contact with the falx cerebri. The pathological analysis showed a cellular proliferation composed of polygonal cells with clear cytoplasm due to the presence of intracytoplasmic vacuoles and round or oval nucleus without cytologic atypia. These cells were accompanied by a rich vascular network of capillary type and blood extravasation. She was diagnosed of supratentorial hemangioblastoma.


CONCLUSIONS
the preoperative diagnosis of these neoplasms is difficult because the clinical suspicion is low in supratentorial location. Imaging techniques are useful but definitive diagnosis is made through pathologic examination. The use of immunohistochemical techniques is helpful for the differential diagnosis with lesions that are more common in this region. The importance of a correct diagnosis of these histologically benign tumors, lies on the possible association with VHL syndrome and its complications.
Servicios de Anatomía Patológica Hospital Universitari Joan XXIII, Tarragona. analiael@yahoo.com
A
A
Elguezabal
M L
ML
Díaz
J
J
Landeyro
M
M
Gené
L
L
Boutayeb
M
M
Escosa
J J
JJ
Sirvent
D000368:Aged; D004388:Dura Mater / Q000033:anatomy & histology / Q000473:pathology; D005260:Female; D018325:Hemangioblastoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015173:Supratentorial Neoplasms / Q000175:diagnosis / Q000473:pathology*; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000175:diagnosis / Q000473:pathology