Effect of gonadotropins on dynamic events and global deoxyribonucleic acid methylation during in vitro maturation of oocytes: an animal model.
Although the redistributions of mitochondria and cortical granules and global DNA methylation status were not altered in a dose-response manner, high dosages of gonadotropin induced spindle and chromosomal abnormalities. The present study highlights the importance of judicious use of gonadotropins and can be applied to clinical stimulation protocols to reduce the potential risks.
Center for Human Reproduction, North Shore-Long Island Jewish Health System, Hofstra University School of Medicine, Manhasset, New York 11030, USA.
Shan
S
Liu
Huai L
HL
Feng
Dennis
D
Marchesi
Zi-Jiang
ZJ
Chen
Avner
A
Hershlag
D000818:Animals; D002417:Cattle; D002869:Chromosome Aberrations / Q000139:chemically induced; D004247:DNA / Q000378:metabolism*; D019175:DNA Methylation / Q000187:drug effects / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006062:Gonadotropins / Q000502:physiology / Q000633:toxicity*; D023421:Models, Animal; D009865:Oocytes / Q000187:drug effects / Q000254:growth & development*; D009866:Oogenesis / Q000187:drug effects / Q000235:genetics
D006062:Gonadotropins; D004247:DNA