Plasma efavirenz in HIV infected children treated with generic antiretroviral drugs in India.
We measured plasma concentration of efavirenz (EFV) in 16 HIV-infected Indian children receiving antiretroviral treatment at Government ART centres. The mean 12 hour concentration was 2.39 ug/mL (range: 0.72- 7.82 ug/mL). The majority of children treated with generic EFV at currently recommended doses had blood levels within the therapeutic range.
Geetha
G
Ramachandran
A K Hemanth
AK
Kumar
M
M
Vasantha
Ira
I
Shah
Soumya
S
Swaminathan
D000480:Alkynes; D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D048588:Benzoxazines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D003521:Cyclopropanes; D016568:Drugs, Generic / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007194:India; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D016568:Drugs, Generic; D018894:Reverse Transcriptase Inhibitors; C098320:efavirenz