2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester.
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good GPx-like activity in the coupled reductase assay.
Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India.
Santosh K
SK
Tripathi
Sagar
S
Sharma
Harkesh B
HB
Singh
Ray J
RJ
Butcher
D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D004952:Esters / Q000138:chemical synthesis*; D005026:Ethylene Glycols / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D018036:Selenium Compounds / Q000737:chemistry*
D002264:Carboxylic Acids; D004952:Esters; D005026:Ethylene Glycols; D016566:Organoselenium Compounds; D018036:Selenium Compounds; C473453:seleninic acid; C005398:phenoxyethanol