[Expansion of the functional domain of chicken alpha-globin genes].
The transcriptional domain of chicken alpha-globin genes was shown to contain the non-globin coding erythroid-specific TMEM8 gene inducible upon terminal differentiation of erythroblasts. Acquirement by the chicken TMEM8 gene of the erythroid-specific expression correlates with its approachment to the cluster of alpha-globin genes as a result of inversion of a 170-kb chromosomal segment. The human TMEM8 gene is located far from the globin genes and is not expressed in erythroblasts. Transcription of the TMEM8 gene and adult globins in differentiated chicken erythroid cells is controlled by alternative activatory hubs sharing two regulatory elements (including the erythroid enhancer). A conclusion is made that in mature erythroblasts these regulatory elements shuttle between two different activatory hubs.
E S
ES
Filonenko
A A
AA
Gavrilov
S V
SV
Razin
O V
OV
Iarovaia
D000818:Animals; D030161:Avian Proteins / Q000096:biosynthesis / Q000235:genetics*; D002645:Chickens / Q000235:genetics*; D002843:Chromatin / Q000235:genetics; D018899:CpG Islands; D004742:Enhancer Elements, Genetic; D004900:Erythroblasts / Q000378:metabolism; D006801:Humans; D008221:Lymphoid Tissue / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D005810:Multigene Family; D055542:alpha-Globins / Q000096:biosynthesis / Q000235:genetics*
D030161:Avian Proteins; D002843:Chromatin; D008562:Membrane Glycoproteins; C414584:TMEM8A protein, human; D055542:alpha-Globins