Serum levels of C-reactive protein in adolescents with periodontitis.
BACKGROUND
The results of several cross-sectional studies suggested a relationship between periodontitis and higher serum levels of C-reactive protein (CRP). Most of these studies were restricted to adult study groups with severe periodontal inflammation, and the potential effects of confounding factors were frequently overlooked.


METHODS
A case-referent study comprised of 87 adolescent cases who presented with clinical attachment loss ≥3 mm recorded in ≥2 of 16 teeth and 73 controls who did not fulfill these criteria was nested in a fully enumerated adolescent population. Venous blood samples were obtained, and CRP levels were quantified, using a high-sensitive bead-based flow cytometric assay. The Mann-Whitney U test was used to assess overall differences between groups.


RESULTS
The median serum CRP values for cases and controls were 64 ng/ml (interquartile range: 27 to 234 ng/ml) and 55 ng/ml (31 to 183 ng/ml), respectively (P = 0.8).


CONCLUSIONS
Serum levels of CRP were not significantly higher among subjects with periodontitis than among controls. However, a statistically significant positive association between percentages of sites with bleeding on probing and log-transformed CRP values was observed.
Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark. rlopez@odont.au.dk
Rodrigo
R
López
Vibeke
V
Baelum
Chris Juul
CJ
Hedegaard
Klaus
K
Bendtzen
D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis* / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D017622:Periodontal Attachment Loss / Q000097:blood* / Q000276:immunology; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood* / Q000276:immunology; D012016:Reference Values; D055815:Young Adult
D002097:C-Reactive Protein