Platelet Survival in Healthy Volunteers After Storage with N-(2-mercaptopropionyl)-glycine.
The sulphhydryl group containing drug N-(2-mercaptopropionyl)-glycine (MPG) was tested as a cytoprotective substance for storage of human platelets for transfusion. Autologous platelets stored for 48 h at 21 ± 1°C in the absence (control-platelets) or in the presence (MPG-platelets) of MPG, respectively, were labelled with Indium-III oxine and retransfused into the healthy donors. Significantly higher survival and a higher spleen/liver-ratio were obtained using stored MPG-platelets compared to stored control-platelets. Additionally, a very strong correlation was found between the percentage of discocytes counted after incubation of stored platelets in fresh plasma in vitro and the survival of stored platelets after retransfusion in vivo.
Institute of Pathobiochemistry, Medical School of Erfurt.
I
I
Bergmann
G
G
Endert
H
H
Hentschel
P
P
Kleinert
G
G
Pescarmona
G U
GU
Reiβ-Zimmermann
R
R
Uhlig
U
U
Till