Glioma-initiating cells: a predominant role in microglia/macrophages tropism to glioma.
The relationship between cancer-initiating cells and cancer-related inflammation is unclear. Exploring the interaction between glioma-initiating cells (GICs) and tumor-associated microglia/macrophages (TAM/Ms) may offer us an opportunity to further understand the inflammatory response in glioma and the cellular/molecular features of the GIC niche. Here，we reported a positive correlation between the infiltration of TAM/Ms and the density of GICs. The capacity of GICs to recruit TAM/Ms was stronger than that of adhesive glioma cells (AGCs) in vitro. In vivo experiments suggested that implantations formed by GICs had a higher level of TAM/M infiltration than those formed by AGCs. Our studies indicate a predominant role of GICs in microglia/macrophages tropism to glioma and a close positive correlation between the distribution of GICs and TAM/Ms. As an important part of cancer-related inflammation, TAM/Ms may participate in the architecture of the GIC niche.
Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China. happyape@126.com
Liang
L
Yi
Hualiang
H
Xiao
Minhui
M
Xu
Xianzong
X
Ye
Jun
J
Hu
Fei
F
Li
Mei
M
Li
Chunxia
C
Luo
Shicang
S
Yu
Xiuwu
X
Bian
Hua
H
Feng
D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D005910:Glioma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000276:immunology*; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000276:immunology* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014183:Transplantation, Heterologous