Diversity of axin in signaling pathways and its relation to colorectal cancer.
Colorectal cancer is one of the commonest cancers in western world, while majority of cases of CRC are sporadic, a significant minority occurs as a result of inherited genetic mutations. Various studies have demonstrated that tumorigenesis of colon arises as a result of accumulation of multiple genetic alterations targeting the single signal transduction pathway. Genetic alteration of axin has been implicated in different cancers including colorectal cancers. Axin being a multidomain protein interacts with multiple proteins and acts as major scaffold protein in signaling pathways like c-jun/SAPK, TGF-β, and Wnt. In different signaling pathways, axin utilizes different domains and hence exerts distinct roles.
Department of Clinical Biochemistry, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir 190011, India. parveennighat24@gmail.com
Nighat
N
Parveen
Mahboob Ul
MU
Hussain
Arshad A
AA
Pandith
Syed
S
Mudassar
D000818:Animals; D060466:Axin Protein / Q000235:genetics* / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D015398:Signal Transduction
D060466:Axin Protein