Biochemical changes in the kidney and liver of rats following administration of ethanolic extract of Psidium guajava leaves.
Furtherance to a previous report on the anti-trypanosomal properties of Psidium guajava aqueous leaf extract in rats experimentally infected with Trypanosoma brucei brucei, we have evaluated the effects of the daily intraperitoneal administration of P. guajava leaf extract to rats on the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and acid phosphatase (ACP) in the kidney, liver and serum. The results obtained revealed that the administration of the extract produced significant increase in the serum activities of AST, ALT, ALP and ACP when compared with the control (p < 0.05). Also AST, ALT and ALP and ACP activities in the tissues of animals administered the extract revealed inconsistent changes (p < 0.05) relative to control. The increase in the serum activity of ALP may be an indicator that there was a likely compromise to the integrity of the plasma membrane as a result of the ethanolic extract administration. This could have caused leakages of the other enzymes investigated, which may explain the corresponding increases in the serum activities of AST, ALT and ACP observed.
Department of Chemical Sciences, College of Natural Sciences, Redeemer's University, Nigeria. adeyemiy@run.edu.ng
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Adeyemi
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Akanji
D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D000431:Ethanol / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry; D031647:Psidium / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D015415:Biomarkers; D010936:Plant Extracts; D000431:Ethanol