A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage.
Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA (25 mg/kg bw) simultaneously. Plasma markers of cardiac damage, cardiac free radical generation, lipid peroxidation, endogenous antioxidant status, cadmium load, metallothionein induction, and histopathology were evaluated in various experimental groups. Combination of Mel + ALA significantly prevented leakage of marker enzymes of cardiac damage, changes in cardiac free radical generation, endogenous antioxidants, antioxidant status, structural alterations and augmented the degree of metallothionein (MT) induction. The results demonstrate that ML + ALA co-administration effectively protected against Cd-induced cardiac oxidative damage.
Division of Cardiotoxicity, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
Raktim
R
Mukherjee
Sudeep
S
Banerjee
Niraj
N
Joshi
Prem Kumar
PK
Singh
Darshee
D
Baxi
A V
AV
Ramachandran
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D019256:Cadmium Chloride; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004798:Enzymes / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006331:Heart Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D008668:Metallothionein / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D008063:Thioctic Acid / Q000494:pharmacology*; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D004798:Enzymes; D014810:Vitamin E; D017665:Hydroxyl Radical; D008315:Malondialdehyde; D008063:Thioctic Acid; D008668:Metallothionein; D006861:Hydrogen Peroxide; D005978:Glutathione; D019256:Cadmium Chloride; D008550:Melatonin; D001205:Ascorbic Acid