Ovarian cyst torsion in a patient with congenital lipoid adrenal hyperplasia.
Congenital lipoid adrenal hyperplasia (CLAH) is the most severe form of congenital adrenal hyperplasia, characterized by lack of synthesis of all gonadal and adrenal steroid hormones. Ovarian cysts can develop as complications of CLAH. However, the precise mechanism of development and natural history of such cysts in patients with CLAH have not yet been determined. We recently treated a 14-year-old female patient with CLAH and ovarian cyst torsion. As a neonate, she presented with vomiting, skin pigmentation, and electrolyte imbalance. At that time, her serum adrenocorticotropic hormone concentration was elevated, while 17-hydroxypregnenolone level was normal, as were her normal female external genitalia. Mutation analysis showed that she was homozygous for p.Q258X in the StAR gene. She underwent spontaneous puberty and menstruation. At 14 years of age, she received salpingo-oophorectomy because of ovarian cyst torsion presenting as acute pelvic pain. Ovarian cysts are important clinical manifestations in 46,XX patients with CLAH, although onset time and severity can vary depending on individuals. Thus, patients with CLAH should be carefully monitored for ovarian complications to preserve as much ovarian function as possible.
Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, 138-736, South Korea.
Hye Young
HY
Jin
Jin-Ho
JH
Choi
Beom Hee
BH
Lee
Gu-Hwan
GH
Kim
Hyung Kyung
HK
Kim
Han-Wook
HW
Yoo
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D010048:Ovarian Cysts / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D010750:Phosphoproteins / Q000235:genetics; D011374:Progesterone / Q000627:therapeutic use; D058994:Salpingectomy; D014102:Torsion Abnormality / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D000098682:Steroidogenic Acute Regulatory Protein
D004967:Estrogens; D010750:Phosphoproteins; D000098682:Steroidogenic Acute Regulatory Protein; D011374:Progesterone