Tissue level of advanced glycation end products is an independent determinant of high-sensitivity C-reactive protein levels in haemodialysis patients.
OBJECTIVE
C-reactive protein (CRP) level predicts future cardiovascular events in patients on haemodialysis (HD). Advanced glycation end products (AGE) play a role in cardiovascular disease (CVD) in HD patients. However, which variables including tissue AGE levels are independently associated with CRP remains unknown. Therefore, whether tissue AGE and CRP levels were correlated with atherosclerosis in HD patients was examined.


METHODS
Fifty-four HD patients underwent determinations of blood chemistries and tissue AGE. Tissue AGE levels were evaluated by measuring skin autofluorescence. Pulsatility index (PI) in the carotid artery was measured using a Doppler ultrasonography.


RESULTS
Univariate analyses showed that age, white blood cells, serum albumin (inversely), alkaline phosphatase (inversely), tartrate-resistant acid phosphatase 5b (TRAP5b) (inversely) and skin AGE levels were significantly correlated with high-sensitivity CRP (hsCRP). Multiple stepwise regression analysis revealed that serum albumin, TRAP5b and skin AGE levels were independent determinants of hsCRP. Further, PI was highest among HD patients with high skin AGE and high hsCRP levels.


CONCLUSIONS
The present study suggests that tissue AGE level is one of the independent determinants of hsCRP in HD patients. Tissue AGE and hsCRP levels may be correlated with each other, which could in concert contribute to the progression of atherosclerosis in these subjects.
Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
Makio
M
Nagano
Kei
K
Fukami
Sho-Ichi
S
Yamagishi
Kazuko
K
Sakai
Yusuke
Y
Kaida
Takafumi
T
Matsumoto
Takuma
T
Hazama
Masahiro
M
Tanaka
Seiji
S
Ueda
Seiya
S
Okuda
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000032:analysis*; D006801:Humans; D007564:Japan; D007674:Kidney Diseases / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D012044:Regression Analysis; D006435:Renal Dialysis; D018570:Risk Assessment; D012307:Risk Factors; D012867:Skin / Q000737:chemistry*; D018608:Ultrasonography, Doppler; D015854:Up-Regulation
D015415:Biomarkers; D017127:Glycation End Products, Advanced; D002097:C-Reactive Protein