[A randomized phase II trial of paclitaxel in combination chemotherapy with platinum in the treatment of non-small cell lung cancer].
BACKGROUND
To compare the efficacy and toxicity of paclitaxel-carboplatin (TAX-CBP) and paclitaxel-cisplatin (TAX-DDP) chemotherapy protocols for advanced non-small cell lung cancer.


METHODS
One hundred and twenty-six patients with non-small cell lung cancer were randomized into TAX-DDP and TAX-CBP groups. TAX-CBP group: TAX 175 mg/m² and CBP 350 mg/m², d1 iv; TAX-DDP group: TAX 175 mg/m² and DDP 100 mg/m² d1 iv. The therapy was repeated every 28 days. The response rate was assessed after three treatments.


RESULTS
TAX-CBP group: response rate (RR) was 36% (22/61), 1-year survival rate was 34.1%. TAX-DDP group: RR was 33.9% (21/62),1-year survival rate was 33.1%. There was no significant difference of RR and 1-year survival rate between TAX-CBP and TAX-DDP group (P>0.05). The median survival time of TAX-CBP group (11.2 months) was significant higher than that of TAX-DDP group (9 months) (P<0.05). The major toxicity associated with paclitaxel included alpecia, myelosuppression, gastrointestinal reaction and myalgia or arthralgia. The thrombocytopenia in TAX-CBP group was more severe than that in TAX-DDP group (P<0.05). The Gastrointestinal and myalgia or arthralgia in TAX-DDP group were more severe than those in TAX-CBP group (P<0.05).


CONCLUSIONS
TAX-CBP and TAX-DDP chemotherapy may be used as first choice protocol in the chemotherapy of non-small cell lung cancer.
Department of Pulmonary Diseases, Shanghai Huadong Hospital, Shanghai 200040, P.R.China.
D
D
Yan
G
G
Wang
G
G
Zhang
C
C
Hu