In vitro activity of ceftaroline against a broad spectrum of recent clinical anaerobic isolates.
The in vitro activity of ceftaroline was compared with those of ceftriaxone, clindamycin, imipenem, metronidazole, moxifloxacin, tigecycline, and vancomycin against 514 clinical anaerobic isolates using Clinical and Laboratory Standards Institute (CLSI) standard methodology. Ceftaroline demonstrated good to excellent activity against Gram-positive anaerobic pathogens and limited activity against Gram-negative pathogens, particularly Bacteroides fragilis group isolates.
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Department of Medicine, Tufts School of Medicine, Boston, MA 02111, USA. dsnydman@tuftsmedicalcenter.org
David R
DR
Snydman
Nilda V
NV
Jacobus
Laura A
LA
McDermott
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002443:Ceftriaxone / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D024841:Fluoroquinolones; D015378:Imipenem / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D000077266:Moxifloxacin; D011804:Quinolines / Q000494:pharmacology; D000078304:Tigecycline; D000097583:Ceftaroline
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D002443:Ceftriaxone; D002511:Cephalosporins; D002981:Clindamycin; D024841:Fluoroquinolones; D015378:Imipenem; D008795:Metronidazole; D008911:Minocycline; D000077266:Moxifloxacin; D011804:Quinolines; D000078304:Tigecycline; D000097583:Ceftaroline