Primary epithelioid angiosarcoma of bone: a case report with immunohistochemical study.
Primary malignant vascular tumors of the bone are exceedingly rare and represent <1% of primary malignant bone tumors. Angiosarcoma is a malignant mesenchymal neoplasm in which the neoplastic cells demonstrate endothelial differentiation. Epithelioid angiosarcoma (EA) is a rare variant of angiosarcoma that is characterized by large cells with an epithelioid morphology. EA is an aggressive tumor with poor prognosis. Here, we present a case of a 62-year-old man who had primary EA of the left tibia. He was treated with amputation and chemotherapy. After 1 month of chemotherapy, he developed pleural effusion and died.
Department of Pathology, Kasturba Medical College, Manipal University, Manipal, India. ranjakudva@yahoo.com
Ranjini
R
Kudva
Shahin
S
Perveen
Aithala
A
Janardhana
D000671:Amputation, Surgical; D018952:Antigens, CD34 / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D004358:Drug Therapy / Q000379:methods; D017809:Fatal Outcome; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D011859:Radiography; D012509:Sarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology*
D018952:Antigens, CD34; D000970:Antineoplastic Agents