Malignant fibrous histiocytoma like pleomorphic leiomyosarcoma with laryngeal cancer as a second primary neoplasm: a case report.
BACKGROUND
Leiomyosarcoma is one of the most common sarcomas arising in the soft tissue and somatic organs. Pleomorphic leiomyosarcoma (P-LMS) may be easily confused with a malignant fibrous histiocytoma (MFH) as both may share nonspecific morphologic features. It is reported that the larynx is the most common site for a second primary neoplasm (SPN) in a patient with a head and neck malignancy, although an SPN of the larynx following a P-LMS is extremely rare.


METHODS
A 57-year-old male initially underwent fine needle aspiration (FNA) of a soft tissue tumor (STS) located in the left upper arm. FNA showed the presence of clustered, large tumor cells with clear, eosinophilic and ill-defined cytoplasm and pleomorphic nuclei. A diagnosis of an undifferentiated malignant tumor was made. Histology showed the presence of MFH. This diagnosis was changed to P-LMS following a lung metastasis. A laryngeal biopsy 37 months after the initial biopsy was performed and showed squamous carcinoma. This squamous carcinoma was presumed to be an SPN.


CONCLUSIONS
This is the first case report of a patient with a P-LMS who then developed laryngeal squamous carcinoma as an SPN.
State Key Laboratory of Biotherapy, Division of Thoracic Oncology, Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Qing-Lian
QL
Wen
Mao-Bin
MB
Meng
Bing-Wen
BW
Zou
You
Y
Lu
D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007890:Leiomyosarcoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*