Gender effects on drug use, abuse, and dependence: a special analysis of results from the National Survey on Drug Use and Health.
BACKGROUND
Gender is increasingly being studied for risk and protective factors underlying substance abuse and addiction.


OBJECTIVE
The aim of this study was to assess gender differences in rates of substance abuse and dependence among drug users.


METHODS
A national population sample was examined, focusing on 2 age groups (youths, aged 12-17 years, and young adults, aged 18-25 years) and several commonly abused substances (alcohol, marijuana, and nonmedical prescription medication use). Combined annual data from the National Survey on Drug Use and Health (NSDUH), aggregated from 2002-2005, were used for gender comparisons of rates of substance use, as well as abuse and dependence, among users.


RESULTS
Overall rates of substance use were significantly higher for males than for females (P < 0.01 for all substances except sedatives and tranquilizers); however, patterns of use, abuse, or dependence among users differed by age group and drug. Interestingly, patterns for youths differed from the overall population and from young adults. Girls exceeded boys in their use of alcohol (P < 0.01) and their nonmedical use of psychotherapeutics (ie, prescription-type pain relievers, stimulants, tranquilizers, sedatives) (P < 0.01); among users, girls were significantly more likely to be dependent on the latter (P < 0.01). Boys reported significantly greater use and abuse of and dependence on marijuana (P < 0.01). In the young adults, the proportion of female users reporting dependence on cocaine or psychotherapeutics was significantly higher than for male users (P < 0.01), who nonetheless reported significantly greater use of these drugs (P < 0.01). Among users, males generally exceeded females in meeting abuse criteria (P < 0.01 for marijuana among 12- to 17-year-olds and for alcohol, marijuana, and psychotherapeutics among 18- to 25-year-olds), with some exceptions mainly in the youngest cohort.


CONCLUSIONS
In this national population sample of youths and young adults, these findings suggest that gender, age, and substance of abuse may all play a role in the observed patterns of drug use, abuse, and dependence. Understanding the reasons for these differences and continuing to evaluate these patterns over time could help in the development of targeted and more effective prevention and treatment interventions.
National Institute on Drug Abuse, Bethesda, Maryland 20892-9591, USA.
Jessica H
JH
Cotto
Elisabeth
E
Davis
Gayathri J
GJ
Dowling
Jennifer C
JC
Elcano
Anna B
AB
Staton
Susan R B
SR
Weiss
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000437:Alcoholism / Q000453:epidemiology*; D002648:Child; D019970:Cocaine-Related Disorders / Q000453:epidemiology*; D005260:Female; D006306:Health Surveys / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000453:epidemiology*; D011619:Psychotropic Drugs; D012737:Sex Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
D011619:Psychotropic Drugs