Bone morphogenic protein-7 serum level decreases significantly in patients with contrast-induced nephropathy.
OBJECTIVE
Previous studies have demonstrated that endogenous bone morphogenic protein-7 (BMP-7) level is reduced in acute kidney injury and administration of exogenous BMP-7 has a beneficial effect on kidney function. In spite of preventive management, contrast-induced nephropathy (CIN) is still the third cause of acute deterioration of kidney function in hospitalized patients. With this background in mind, we studied changes in serum BMP-7 in a group of patients with chronic kidney disease and contrast-induced nephropathy.


METHODS
We enrolled 45 consecutive adult patients with a baseline serum creatinine ≥ 1.4 mg/dl admitted for coronary angiography. We measured serum BMP-7 levels before and 48 h after coronary angiography. The primary end point was the development of CIN, defined as an increase in serum creatinine concentration by 0.25 mg/dl or 25% over the baseline value within 72 h from contrast exposure.


RESULTS
Overall, CIN occurred in 8 (17%) patients. The concentrations of serum BMP-7 were significantly decreased in the CIN group compared to baseline (488.6 ± 56.8 vs. 356.4 ± 24.8, P = 0.01); in contrast, the concentration of BMP-7 level did not change in patients without CIN (444.6 ± 54.6 vs. 440.0 ± 53.9, P = 0.09).


CONCLUSIONS
BMP-7 level significantly decreases in patients who develop CIN after coronary angiography. Therefore, BMP-7 might be a diagnostic biomarker for CIN and a possibly promising agent for the treatment of CIN.
Department of Internal Medicine, Section of Nephrology, Ankara Training and Research Hospital, Ankara, Turkey.
Murat
M
Duranay
Liviu
L
Segall
Nihat
N
Sen
Fatma Melik
FM
Yilmaz
Mustafa
M
Cetin
Ahmet
A
Isleyen
Mehmet
M
Kanbay
Adrian
A
Covic
D000368:Aged; D015415:Biomarkers / Q000097:blood; D055419:Bone Morphogenetic Protein 7 / Q000097:blood*; D002908:Chronic Disease; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D055419:Bone Morphogenetic Protein 7; D003287:Contrast Media; D003404:Creatinine