Clinical research into Qufeng Zhidong Recipe used to treat 31 children with tic disorder.
OBJECTIVE
To assess the therapeutic effect and adverse reaction of Qufeng Zhidong Recipe (a recipe for dispelling wind to stop abnormal movement) used to treat children with tic disorder (TD).


METHODS
The enrolled patients were randomized into a TCM group (31 cases) treated with Qufeng Zhidong Recipe and a Western medicine group (30 cases) treated with haloperidol and trihexyphenidyl. Two courses of treatment were observed with 12 weeks as one course. The therapeutic effect and adverse reaction were assessed with Yale Global Tic Severity Scale (YGTSS), Tic Symptom Score Scale (TSSS), TCM Syndrome Score Scale (TCMSSS), Treatment Emergent Symptom Scale (TESS) and laboratory examinations.


RESULTS
The total effective rate was 100% in the TCM group and 60% in the Western medicine group with statistical significance in difference (P < 0.05). All the scores in the TCM group were better than those in the Western medicine group (P < 0.05).


CONCLUSIONS
Qufeng Zhidong Recipe can obviously relieve the symptoms and signs of TD children without toxic side-effects.
Xinhua Hospital affiliated to Medical College of Shanghai Jiaotong University, Shanghai 200092, China. xinhuayiyuan123@126.com
Min
M
Wu
Guang-Hua
GH
Xiao
Jian-Ming
JM
Zhang
Xin
X
Zhang
Bo
B
Ma
Shu-Xia
SX
Wang
Ya-Bing
YB
Zhou
Jing-Yan
JY
Zhang
D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D013981:Tic Disorders / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; C545315:qufeng zhidong