Copper-catalyzed decarboxylative cross-coupling of alkynyl carboxylic acids with aryl halides.
The copper-catalyzed decarboxylative reactions of alkynyl carboxylic acids with aryl halides were performed under relatively mild reaction conditions. Benzofurans could be further prepared smoothly by a one-pot domino protocol on the basis of decarboxylative cross-coupling of 2-iodophenol.
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P.R. China.
Dongbing
D
Zhao
Chao
C
Gao
Xiaoyu
X
Su
Yunqing
Y
He
Jingsong
J
You
Ying
Y
Xue
D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D006219:Halogens / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry
D001572:Benzofurans; D002264:Carboxylic Acids; D006219:Halogens; D007462:Iodobenzenes; D003300:Copper; C011289:2-iodophenol