Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi.
In an investigation into their potential ecological role(s), a group of mainly diterpene isonitriles, nine in total, isolated from the tropical marine sponge Cymbastela hooperi, and the sesquiterpene axisonitrile-3, isolated from the tropical marine sponge Acanthella kletra, were evaluated in a series of bioassays including anti-fouling, anti-algal, anti-photosynthetic, anti-bacterial (Gram +ve and -ve), anti-fungal, and anti-tubercular. The results of these assays showed that all of the tested compounds, with the exception of diterpene 9, were active in at least two of the applied test systems, with axisonitrile-3 (10) and diterpene isonitrile 1 being the two most active compounds overall, closely followed by diterpene isonitrile 3. Based on the results of the photosynthetic study a molecular modelling investigation was undertaken with all of the compounds used in that study. The results showed a positive correlation between reduction in photosynthetic activity and the interaction of the modelled compounds with a potential enzyme active site.
College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA. adwright@hawaii.edu
Anthony D
AD
Wright
Adam
A
McCluskey
Mark J
MJ
Robertson
Kylie A
KA
MacGregor
Christopher P
CP
Gordon
Jana
J
Guenther
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D047089:Axinella / Q000737:chemistry*; D057219:Biofouling; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D010788:Photosynthesis / Q000187:drug effects
D000890:Anti-Infective Agents; D004224:Diterpenes; D006454:Hemoglobins; D009570:Nitriles