Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents.
A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC(50) range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.
Medicinal and Process Chemistry Division, Central Drug Research Institute, (CDRI-CSIR), Lucknow, India. sashidhar123@gmail.com
Koneni V
KV
Sashidhara
Abdhesh
A
Kumar
Manoj
M
Kumar
Jayanta
J
Sarkar
Sudhir
S
Sinha
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D047188:Chalcones; D003374:Coumarins