[High-sensitivity C-reactive protein and changes over time in forced expiratory volume in 1 second in adult-onset asthma].
OBJECTIVE
To study the possibility that changes in high-sensitivity C-reactive protein (hs-CRP) may be a predictor of forced expiratory volume in 1 second (FEV1) decline over time in adult asthmatic subjects.


METHODS
Subjects with adult-onset asthma with no smoking history underwent complete medical evaluation at Yoka Public Hospital in both 2005 and in 2008 (n = 26). We analyzed the correlation between hs-CRP levels and FEV1 changes over time, in relation to whether or not they received inhaled corticosteroid (ICS) therapy. We also measured the cardio-ankle vascular index (CAVI), intima-media-thickness (IMT), and fraction of exhaled nitric oxide (FeNO) of hospital staff members who acted as non ICS asthmatic subjects (n = 11), and also performed multiple regression analysis.


RESULTS
In the non-ICS asthmatic subjects group (n = 19), there was a significant correlation between log (hs-CRP) levels and FEV1 changes (R = -0.734, P < 0.001). After controlling for age, body mass index, CAVI, IMT, and FeNO, hs-CRP was found to be an independent risk factor.


CONCLUSIONS
Hs-CRP levels are a predictor of FEV1 decline over time in adult-onset asthmatic patients with no smoking history, who are not receiving ICS therapy.
Department of Respiratory Medicine, National Hospital Organization Himeji Medical Center.
Yasuyuki
Y
Mizumori
Satoru
S
Katayama
Tadashi
T
Igishi
Yoshiro
Y
Mochiduki
Yasuharu
Y
Nakahara
Tetsuji
T
Kawamura
Koji
K
Maniwa
Haruhiko
H
Makino
Miki
M
Yamamura
Satoshi
S
Terashita
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D012907:Smoking / Q000009:adverse effects
D002097:C-Reactive Protein