BMP-2: a culprit for anemia in myeloma.
Maes and colleagues(1) have found increased BMP-2 in the blood of multiple myeloma patients as an important stimulator of hepcidin in addition to other well-known mediators of hepcidin induction. These findings were obtained by transfection of human liver HuH7 cells with reporter constructs for the hepcidin promoter carrying either mutations in BMP-response elements or in STAT3-binding sites.
Wilhelminenspital, Center for Oncology and Hematology.
Heinz
H
Ludwig