The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice.
In this study, the effect of daidzin or daidzein isolated from Pueraria lobata on the memory impairments induced by scopolamine was assessed in male mice using the passive avoidance and the Morris water maze tasks. Administration of daidzin (5 mg/kg) or daidzein (5 mg/kg) significantly reversed the scopolamine (1 mg/kg)-induced cognitive impairments in male mice as evidenced by the passive avoidance test (p < 0.05) and on the Morris water maze test (p < 0.05). Moreover, the ameliorating effects of daidzin or daidzein were antagonized by tamoxifen (1 mg/kg), the nonspecific estrogen receptor antagonist. These results indicate that daidzin or daidzein may be useful in cognitive impairment induced by cholinergic dysfunction, and this beneficial effect is mediated, in part, via estrogen receptor.
Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea.
Dong Hyun
DH
Kim
Hyun Ah
HA
Jung
Se Jin
SJ
Park
Jong Min
JM
Kim
Seungjoo
S
Lee
Jae Su
JS
Choi
Jae Hoon
JH
Cheong
Kwang Ho
KH
Ko
Jong Hoon
JH
Ryu
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D018680:Cholinergic Antagonists / Q000633:toxicity*; D004965:Estrogen Antagonists / Q000494:pharmacology; D005960:Glucosides / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D007529:Isoflavones / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D007859:Learning Disabilities / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D048789:Phytoestrogens / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D011960:Receptors, Estrogen / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D012601:Scopolamine / Q000633:toxicity*; D013550:Swimming; D013629:Tamoxifen / Q000494:pharmacology
D018680:Cholinergic Antagonists; D004965:Estrogen Antagonists; D005960:Glucosides; D007529:Isoflavones; D048789:Phytoestrogens; D011960:Receptors, Estrogen; D013629:Tamoxifen; C013908:daidzin; C004742:daidzein; D012601:Scopolamine