Impaired avidity maturation after tetanus toxoid booster in children with Down syndrome.
Down syndrome children show a decreased avidity of the antibody response after tetanus toxoid booster vaccination at 9 years of age suggesting impaired memory B cell selection in the germinal center. Clinicians need to be aware of this ongoing subtle immunologic deficit in Down syndrome.
Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Maaike A
MA
Kusters
C M
CM
Jol-van der Zijde
Maarten J
MJ
van Tol
W E
WE
Bolz
L A
LA
Bok
Marjan
M
Visser
Esther
E
de Vries
D000907:Antibodies, Bacterial / Q000097:blood*; D000915:Antibody Affinity; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome; D006801:Humans; D007117:Immunization, Secondary; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology*
D000907:Antibodies, Bacterial; D013745:Tetanus Toxoid