Chiral phosphine-squaramides as enantioselective catalysts for the intramolecular Morita-Baylis-Hillman reaction.
Novel squaramides containing tertiary phosphine were developed as chiral bifunctional organic catalysts to promote the asymmetric intramolecular Morita-Baylis-Hillman reaction of ω-formyl-enones. The adducts were obtained in high yields with good-to-excellent enantioselectivity (up to 93% ee).
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China.
Hong-Liang
HL
Song
Kui
K
Yuan
Xin-Yan
XY
Wu