Anti-ulcer and antioxidant activity of GutGard.
The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. GutGard dose dependently decreased gastric content, total acidity, ulcer index and increased pH of gastric fluid in pylorus ligation ulcer model. In cold-restraint stress- and indomethacin induced ulcer models all the doses of GutGard decreased the ulcer index and increased the pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGardT exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value. GutGard possessed anti-ulcerogenic properties that might be afforded via cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.
PES College of Pharmacy, Bengaluru 560 050, India.
Moumita
M
Mukherjee
Natarajan
N
Bhaskaran
R
R
Srinath
H N
HN
Shivaprasad
J Joshua
JJ
Allan
D
D
Shekhar
Amit
A
Agarwal
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006035:Glycyrrhiza / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007213:Indomethacin; D008026:Ligation / Q000009:adverse effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011708:Pylorus / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000737:chemistry; D012149:Restraint, Physical / Q000009:adverse effects; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications
D000897:Anti-Ulcer Agents; D000975:Antioxidants; C554040:GutGard; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D007213:Indomethacin