Evaluation of an influenza-like illness case definition in the diagnosis of influenza among patients with acute febrile illness in Cambodia.
BACKGROUND
Influenza-like illness (ILI) is often defined as fever (>38.0°C) with cough or sore throat. In this study, we tested the sensitivity, specificity, and positive and negative predictive values of this case definition in a Cambodia patient population.


METHODS
Passive clinic-based surveillance was established at nine healthcare centers to identify the causes of acute undifferentiated fever in patients aged two years and older seeking treatment. Fever was defined as tympanic membrane temperature >38°C lasting more than 24 hours and less than 10 days. Influenza virus infections were identified by polymerase chain reaction.


RESULTS
From July 2008 to December 2008, 2,639 patients were enrolled. From 884 (33%) patients positive for influenza, 652 presented with ILI and 232 acute fever patients presented without ILI. Analysis by age group identified no significant differences between influenza positive patients from the two groups. Positive predictive values (PPVs) varied during the course of the influenza season and among age groups.


CONCLUSIONS
The ILI case definition can be used to identify a significant percentage of patients with influenza infection during the influenza season in Cambodia, assisting healthcare providers in its diagnosis and treatment. However, testing samples based on the criteria of fever alone increased our case detection by 34%.
U.S. Naval Medical Research Unit 2, Jakarta, Indonesia. kaspernamru2@yahoo.com
Matthew R
MR
Kasper
Thomas F
TF
Wierzba
Ly
L
Sovann
Patrick J
PJ
Blair
Shannon D
SD
Putnam
D000293:Adolescent; D000328:Adult; D002160:Cambodia; D002648:Child; D003371:Cough / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007251:Influenza, Human / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D010612:Pharyngitis / Q000175:diagnosis / Q000209:etiology; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D055815:Young Adult
D012367:RNA, Viral