[A genetic background of ulcer diseases induced by NSAID/aspirin].
The association between peptic ulcer diseases and polymorphisms in various genes, including HRH2, COX-1, IL-17A. IL-17F, MIF and Nrf2 genes, are seen. COX-1 has traditionally been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. The effects of NSAID/aspirin on the gastric mucosal damage are caused by the inhibition of this enzyme. A T-1676C polymorphism (rs1330344) was significantly associated with the development of peptic ulcer, especially gastric ulcer. In addition, rs1330344 was also significantly associated with the development of NSAID/aspirin-induced ulcer diseases. In conclusions, the assessment for genotype of COX-1 gene promoter polymorphism, especially rs1330344, may be useful for detecting the high risk group of developing NSAID/aspirin-induced ulcer diseases.
Department of Gastroenterology, Kanazawa Medical University.
Tomiyasu
T
Arisawa
Tomomitsu
T
Tahara
Masakatsu
M
Nakamura
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D051545:Cyclooxygenase 1 / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000235:genetics*; D011110:Polymorphism, Genetic
D000894:Anti-Inflammatory Agents, Non-Steroidal; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin