Benign metastasizing leiomyoma.
Benign metastasizing leiomyoma (BML) is a rare condition, affecting predominantly reproductive-age females with uterine leiomyomata and is most often associated with multiple benign-appearing smooth muscle tumors in lungs. We report herein a case of a 38-year-old woman who presented with multiple uterine fibroids for which hysterectomy was carried out on her. Postoperatively, she developed left-sided pleural effusion. Computed chest tomography (CT) scan revealed multiple nodules in both lungs and pleurae. Histopathology of one of the pleura-based nodules revealed a neoplasm composed of interlacing fascicles of spindle cells with uniform nuclei. The tumor cells were positive for alpha-smooth muscle actin and negative for CD34 immunohistochemical stain.
Department of Pathology, Aga Khan University Hospital, Karachi, Pakistan. saira.fatima@aku.edu.com
Saira
S
Fatima
Zubair
Z
Ahmed
Mohammad
M
Azam
D000199:Actins / Q000032:analysis; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000175:diagnosis* / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008853:Microscopy; D010996:Pleural Effusion / Q000175:diagnosis; D010997:Pleural Neoplasms / Q000473:pathology / Q000556:secondary*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
C541116:ACTA2 protein, human; D000199:Actins; D018952:Antigens, CD34