Novel cyclization of bis-Boc-guanidines: expeditive traceless synthesis of 1,3,5-oxadiazinones under microwave conditions.
A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones by a traceless synthesis.
Laboratory of Combinatorial Drug Discovery, Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300-10, Taiwan.
Gorakh S
GS
Yellol
Tsai-Wen
TW
Chung
Chung-Ming
CM
Sun
D000588:Amines; D001389:Azirines / Q000737:chemistry*; D003500:Cyclization; D004095:Dihydropyridines / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry*; D008872:Microwaves; D011092:Polyethylene Glycols
D000588:Amines; D001389:Azirines; D004095:Dihydropyridines; D006146:Guanidines; C069267:diazipine; D011092:Polyethylene Glycols