Myocardial perfusion imaging using technetium-99m sestamibi in asymptomatic diabetic patients.
Myocardial perfusion single-photon emission computed tomography (SPECT) has been extensively applied in the clinical assessment of patients with diabetes mellitus. The aim of the present study was to evaluate stress technetium-99m sestamibi SPECT MPI perfusion in silent myocardial ischemia and its association with some clinical and laboratory parameters in an asymptomatic diabetic population.


METHODS
83 subjects (age: 57.1±6.9 years) with at least five years history of type 2 diabetes, and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging; angiography was also performed in patients with abnormal MPI.


RESULTS
MPI results showed that 58 patients had normal myocardial perfusion, while 25 patients showed perfusion defects (23 reversible and 2 fixed) on MPI. 12 out of the 25 (48%) with abnormal MPI findings represented abnormal angiography. We observed that pretest likelihood of CAD (odds ratio 2.32; 95%-CI: 1.05-5.13; p = 0.038) and higher HbA1c level (odds ratio 1.70; 95%-CI, 1.07-2.71; p = 0.02) were independently associated with abnormal MPI.


CONCLUSIONS
Occult CAD was present on MPI in 1/3 patients with DM without abnormal electrocardiographic findings or evidence of peripheral arterial disease.
Majid Assadi, MDBushehr Research Center for Nuclear Medicine The Persian Gulf Biomedical Sciences Institute, Boostan 19 Alley, Imam Khomeini Street, Bushehr, Iran.
A
A
Mohagheghie
M N
MN
Ahmadabadi
D K
DK
Hedayat
M R
MR
Pourbehi
M
M
Assadi
D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000000981:diagnostic imaging*; D058065:Diabetic Cardiomyopathies / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi