SAR studies of gymnasterkoreayne derivatives with cancer chemopreventive activities.
We synthesized diyne triols based on gymnasterkoreayne and evaluated their cancer chemopreventive activities in terms of the chemopreventive index (CI) to reveal the structure-activity relationship, and discovered more active compounds than natural diynes.
Life/Health Division, Korea Institute of Science and Technology (KIST), Seongbuk-Gu, Seoul, Republic of Korea. dyshin21@kist.re.kr
Dongyun
D
Shin
Jung-Eun
JE
Yang
Saet Byoul
SB
Lee
Chu Won
CW
Nho
D000114:Acetylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D053281:Enediynes / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship
D016588:Anticarcinogenic Agents; D053281:Enediynes; C468047:gymnasterkoreaside B; C505039:gymnasterkoreayne G; D000114:Acetylene