Inflammation and genetic risk indicators for early periodontitis in adults.
BACKGROUND
This report is a further analysis of a study designed to determine clinical and microbial risk indicators for progressing periodontitis.


METHODS
One hundred ninety subjects who were periodontally healthy or had early signs of periodontitis (age range: 20 to 40 years) were monitored clinically at 6-month intervals followed by supragingival cleaning. At each visit, gingival crevicular fluid (GCF) and blood were collected for determination of interleukin (IL)-1β content (in GCF) and IL-1 genotype (in blood). Interproximal sites with a >1.5-mm increase in clinical attachment over 18 months were considered disease active. Characteristics were compared between active and inactive subjects.


RESULTS
IL-1β levels in GCF increased with the severity of disease and correlated well with clinical signs of incipient disease. However, the IL-1 genotype did not show any significant associations with disease or the extent of disease.


CONCLUSIONS
Indicators of inflammation may be important clinical determinants of future periodontal disease progression, but the IL-1 genotype was not a risk indictor for early (slight) periodontitis as defined in this subject population.
Department of Cytokine Biology, The Forsyth Institute, Boston, MA, USA.
Philip
P
Stashenko
Thomas
T
Van Dyke
Patrice
P
Tully
Ralph
R
Kent
Stephen
S
Sonis
Anne C R
AC
Tanner
D000328:Adult; D017668:Age of Onset; D005260:Female; D020022:Genetic Predisposition to Disease; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D053583:Interleukin-1beta / Q000032:analysis / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D010518:Periodontitis / Q000235:genetics* / Q000276:immunology; D012720:Severity of Illness Index; D055815:Young Adult
D053583:Interleukin-1beta