Evaluation of N-terminal prohormone B-type natriuretic Peptide in patients with acute coronary syndromes and percutaneous coronary intervention.
The aim of this research was to describe N-terminal part of the prohormone B-type natriuretic peptide (NT-proBNP) levels over time in patients with acute coronary syndrome (ACS) before and after percutaneous coronary intervention (PCI). NT-proBNP, troponin I (Tn-I), creatine kinase (CK), CK MB isoenzyme (CKMB), fibrinogen, D-dimers, and C-reactive protein (CRP) were measured in 300 consecutive patients with ACS before undergoing successful reperfusion with PCI in the first 48 hours, 2 days after, and at the end of the 1st, 3rd, 6th, 12th, 18th, and 24th month. The concentration of NT-proBNP was cross-correlated with the levels of NT-proBNP in 300 patients without ACS and was significantly increased before and after PCI and at the end of the 3rd month, contrasting with the fast conversion to normal levels of Tn-I, CK, CKMB, fibrinogen, D-dimers, and CRP. In patients with ACS undergoing successful PCI, NT-proBNP shows slow kinetics, especially in patients with an increased thrombolysis in myocardial infarction risk score, hypertension, and diabetes. Nevertheless, cardiac neurohormonal activation may be a unifying feature among patients at high risk for cardiovascular events after ACS and PCI.
Department of Cardiology, Catheterization Laboratory, General Air Force Hospital, Athens, Greece. konlampropoulos@yahoo.gr
Konstantinos M
KM
Lampropoulos
Andreas
A
Marinakis
Dimitrios P
DP
Sokolis
Themistoklis A
TA
Iliopoulos
D054058:Acute Coronary Syndrome / Q000097:blood / Q000628:therapy; D000209:Acute-Phase Proteins / Q000378:metabolism; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000187:drug effects / Q000378:metabolism; D010446:Peptide Fragments / Q000187:drug effects / Q000378:metabolism; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018570:Risk Assessment; D015912:Thrombolytic Therapy / Q000009:adverse effects; D013997:Time Factors; D019210:Troponin I / Q000378:metabolism
D000209:Acute-Phase Proteins; D015415:Biomarkers; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D052279:Creatine Kinase, MB Form