Idiosyncratic drug-induced liver injury: a clinical update.
Drug-induced liver injury (DILI) is a rare but potentially devastating adverse drug reaction. Its presentation can range from asymptomatic elevation in liver biochemistries to fulminant liver failure. Over the past decade, clinical and research interest in the field of idiosyncratic DILI has been intense, and several new findings have been reported. In this article, we provide an update on implicated agents, clinical features, outcomes, and the results of recently reported genetic studies.
Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Haripriya
H
Maddur
Naga
N
Chalasani
D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D004341:Drug Evaluation; D055106:Genome-Wide Association Study; D006801:Humans; D012307:Risk Factors