Correlation between serum and plasma antibody titers to mycobacterial antigens.
The ability to utilize serum or plasma samples interchangeably is useful for tuberculosis (TB) serology. We demonstrate a strong correlation between antibody titers to several mycobacterial antigens in serum versus plasma from HIV-infected and non-HIV-infected TB and non-TB patients (r = 0.99 to 0.89; P < 0.0001). Plasma and serum can be used interchangeably in the same antibody detection assays.
Graduate Division of Biomedical Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Michael
M
Siev
Xian
X
Yu
Rafael
R
Prados-Rosales
Frank T
FT
Martiniuk
Arturo
A
Casadevall
Jacqueline M
JM
Achkar
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D008292:Malate Synthase / Q000276:immunology; D008297:Male; D008351:Mannans / Q000276:immunology; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010949:Plasma / Q000276:immunology*; D044967:Serum / Q000276:immunology*; D014376:Tuberculosis / Q000150:complications / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C082911:MPT51 protein, Mycobacterium; D008351:Mannans; C012189:arabinomannan; D008292:Malate Synthase