Inhibition of plasma hyaluronan-binding protein autoactivation by laccaic acid.
Plasma hyaluronan-binding protein (PHBP) is a serine protease implicated in proteolysis under inflammatory conditions. We identified laccaic acid, a widely used food coloring from scale insects, as a potent inhibitor of the protease in terms of both autoactivation of the PHBP proenzyme (IC(50) = 0.35-0.55 µg/ml) and the catalytic activity of the active enzyme (IC(50) = 1.1 µg/ml).
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Japan.
Chikako
C
Sekido
Naoko
N
Nishimura
Masayuki
M
Takai
Keiji
K
Hasumi
D001391:Azo Compounds / Q000494:pharmacology*; D002384:Catalysis; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D018960:Hyaluronan Receptors / Q000187:drug effects*; D007249:Inflammation; D020128:Inhibitory Concentration 50; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*
D001391:Azo Compounds; D018960:Hyaluronan Receptors; D015842:Serine Proteinase Inhibitors; C009765:lac dye