Active and passive immunization against Acinetobacter baumannii using an inactivated whole cell vaccine.
The treatment of infections caused by Acinetobacter baumannii has become increasingly complicated due to the emergence of highly resistant strains. In the present study we demonstrate that immunization with an inactivated whole cell vaccine elicits a robust antibody response that provides protection against challenge with multiple A. baumannii strains in a murine model of disseminated sepsis. In addition, we show that passive immunization with serum raised against inactivated cells protects mice from subsequent infection. These results demonstrate that active and passive immunization using an inactivated whole cell vaccine may be an effective approach for preventing infection by A. baumannii.
Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla, University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain. mmcconn@umich.edu
Michael J
MJ
McConnell
Jerónimo
J
Pachón
D000151:Acinetobacter Infections / Q000517:prevention & control*; D040981:Acinetobacter baumannii / Q000276:immunology*; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007106:Immune Sera / Q000008:administration & dosage / Q000276:immunology; D007116:Immunization, Passive / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D018805:Sepsis / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
D001428:Bacterial Vaccines; D007106:Immune Sera; D015164:Vaccines, Inactivated