Cleavage isn't everything: potential novel mechanisms of exfoliative toxin-mediated blistering.
This Commentary describes breakthroughs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated blistering skin diseases.
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA.
Takeru
T
Funakoshi
Aimee S
AS
Payne
D000818:Animals; D001768:Blister / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D051183:Desmoglein 1 / Q000235:genetics / Q000502:physiology; D005083:Exfoliatins / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology / Q000235:genetics / Q000628:therapy; D051379:Mice; D010392:Pemphigus / Q000151:congenital / Q000209:etiology / Q000235:genetics / Q000628:therapy; D011499:Protein Processing, Post-Translational / Q000235:genetics / Q000502:physiology*; D013206:Staphylococcal Scalded Skin Syndrome / Q000150:complications / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D051185:gamma Catenin / Q000235:genetics / Q000502:physiology
D051183:Desmoglein 1; D005083:Exfoliatins; D051185:gamma Catenin