Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni.
Two novel alkaloids, wilsoniamines A and B, both possessing a hexahydropyrrolo[1,2-c]imidazol-1-one ring system that has not previously been found in nature, together with a new alkaloid, amathamide H and a known alkaloid, amathamide C were isolated from the temperate Australian bryozoan, Amathia wilsoni. MS and NMR analysis established the structure of the new compounds and indicated that the structure of amathamide C and several related compounds be revised. Amathamides C and H showed moderate anti-malarial and anti-trypanosomal activity.
Environmental Futures Centre, Griffith University, Gold Coast, QLD 4222, Australia. a.carroll@griffith.edu.au
Anthony R
AR
Carroll
Sandra
S
Duffy
Melissa
M
Sykes
Vicky M
VM
Avery
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D002013:Bryozoa / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry* / Q000302:isolation & purification; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification
D000470:Alkaloids; D007093:Imidazoles; D011758:Pyrroles; C556473:wilsoniamine A; C556474:wilsoniamine B