Industrial-scale manufacturing of a possible oligonucleotide cargo CPP-based drug.
This chapter describes the manufacturing process to a certain level for a possible oligonucleotide cargo and a peptide API in a multi-kilogram scale from a manufacture's point of view. In the concluding remarks, possible conjugation methods will be discussed from an industrial-scale perspective.
GE Healthcare Bio-Sciences, Uppsala, Sweden.
Ulf
U
Tedebark
Anthony
A
Scozzari
Oleg
O
Werbitzky
Daniel
D
Capaldi
Lars
L
Holmberg
D057846:Cell-Penetrating Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D056148:Chromatography, Reverse-Phase; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D004345:Drug Industry; D005449:Fluorenes / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D012117:Resins, Synthetic / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
C496789:9-fluorenylmethoxycarbonyl; D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D005449:Fluorenes; D007202:Indicators and Reagents; D009841:Oligonucleotides; D012117:Resins, Synthetic; D012997:Solvents