Opening ahead: early steps in lumen formation revealed.
The contribution and order of polarity complexes and vesicular trafficking events during lumen formation remains obscure. Now, lumenogenesis in MDCK cell cysts is shown to require a Rab11a-Rabin8-Rab8a network that recruits Sec15A and Cdc42 and that promotes apical exocytosis by enlisting the Par complex and Sec8-Sec10 to an early apical membrane initiation site.
Gerard
G
Apodaca
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004285:Dogs; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D000081410:Germinal Center Kinases; D007668:Kidney / Q000166:cytology / Q000196:embryology*; D008954:Models, Biological; D009024:Morphogenesis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D000099193:rab11 GTP-Binding Proteins
D000081410:Germinal Center Kinases; D017346:Protein Serine-Threonine Kinases; D020764:cdc42 GTP-Binding Protein; D020691:rab GTP-Binding Proteins; D000099193:rab11 GTP-Binding Proteins