[A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs].
The chemical advances of the 20th century led to the synthesis of non steroidal anti-inflammatory drugs (NSAIDs), beginning from phenylbutazone and indomethacin and continuing with other new drugs, including ibuprofen, diclofenac, naproxen, piroxicam and, more recently, the highly selective COX-2 inhibitors (coxibs). This progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane.
Università di Pisa, Italia.
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000266:history* / Q000494:pharmacology / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000266:history* / Q000494:pharmacology / Q000627:therapeutic use; D001671:Biochemistry / Q000266:history; D016861:Cyclooxygenase Inhibitors / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use; D015232:Dinoprostone / Q000096:biosynthesis; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D010146:Pain / Q000188:drug therapy; D011448:Prostaglandin Antagonists / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D016861:Cyclooxygenase Inhibitors; D011448:Prostaglandin Antagonists; D015232:Dinoprostone