Validation of genome-wide prostate cancer associations in men of African descent.
BACKGROUND
Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent.


METHODS
We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci.


RESULTS
We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2.


CONCLUSIONS
We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.


CONCLUSIONS
The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent.
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.
Bao-Li
BL
Chang
Elaine
E
Spangler
Stephen
S
Gallagher
Christopher A
CA
Haiman
Brian
B
Henderson
William
W
Isaacs
Marnita L
ML
Benford
LaCreis R
LR
Kidd
Kathleen
K
Cooney
Sara
S
Strom
Sue Ann
SA
Ingles
Mariana C
MC
Stern
Roman
R
Corral
Amit D
AD
Joshi
Jianfeng
J
Xu
Veda N
VN
Giri
Benjamin
B
Rybicki
Christine
C
Neslund-Dudas
Adam S
AS
Kibel
Ian M
IM
Thompson
Robin J
RJ
Leach
Elaine A
EA
Ostrander
Janet L
JL
Stanford
John
J
Witte
Graham
G
Casey
Rosalind
R
Eeles
Ann W
AW
Hsing
Stephen
S
Chanock
Jennifer J
JJ
Hu
Esther M
EM
John
Jong
J
Park
Klara
K
Stefflova
Charnita
C
Zeigler-Johnson
Timothy R
TR
Rebbeck
D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D015203:Reproducibility of Results; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D001741:Black or African American