Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment.
OBJECTIVE
Flow-diverting approaches to intracranial aneurysm treatment had many promising early results, but recent apparently successful treatments have been complicated by later aneurysm hemorrhage. We analyzed 7 cases of aneurysms treated with flow diversion to explore the possible rupture mechanisms.


METHODS
CFD analysis of pre- and posttreatment conditions was performed on 3 giant aneurysms that ruptured after treatment and 4 successfully treated aneurysms. Pre- and posttreatment hemodynamics were compared including WSS, relative blood flows, vascular resistances, and pressures, to identify the effects of flow-diverter placements.


RESULTS
Expected reductions in aneurysm velocity and WSS were obtained, indicating effective flow diversion from the sac into the parent artery, consistent with periprocedural observations. In each case with postaneurysm rupture, the result of flow diversion led to an increase in pressure within the aneurysm. This pressure increase is related to larger effective resistance in the parent artery from placement of the devices and, in 2 cases, the reduction of a preaneurysm stenosis.


CONCLUSIONS
Flow-diversion devices can cause intra-aneurysmal pressure increases, which can potentially lead to rupture, especially for giant aneurysms. This relates both to changes in the parent artery configuration, such as reduction of a proximal stenosis, and to the flow diversion into higher resistance parent artery pathways combined with cerebral autoregulation, leading to higher pressure gradients. These may be important effects that should be considered when planning interventions. Potentially dangerous cases could be identified with angiography and/or patient-specific CFD models.
Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030, USA. jcebral@gmu.edu
J R
JR
Cebral
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Mut
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M
Raschi
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Scrivano
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Ceratto
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Lylyk
C M
CM
Putman
D000328:Adult; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000503:physiopathology; D002548:Cerebral Revascularization / Q000009:adverse effects / Q000295:instrumentation; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015607:Stents / Q000009:adverse effects*; D016896:Treatment Outcome