Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats.
Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey Nuevo León, México.
Lourdes
L
Garza-Ocañas
Domingo A
DA
Ferrer
Justin
J
Burt
Luis A
LA
Diaz-Torres
Mónica
M
Ramírez Cabrera
Victor Tamez
VT
Rodríguez
Rubén
R
Luján Rangel
Dwight
D
Romanovicz
Miguel
M
Jose-Yacaman
D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D005260:Female; D006651:Histocytochemistry; D008099:Liver / Q000378:metabolism; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D009206:Myocardium / Q000378:metabolism; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D012834:Silver / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D012710:Serum Albumin, Bovine; D012834:Silver