Rhodium/diene-catalyzed asymmetric arylation of N-sulfonyl indolylimines: a new access to highly optically active α-aryl 3-indolyl-methanamines.
A new and efficient method for the preparation of highly enantiomerically enriched α-aryl 2- or 3-indolyl-methanamines by rhodium-catalyzed asymmetric arylation of N-sulfonyl indolylimines with arylboronic acids using chiral bicyclo[3.3.0] diene was developed.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
Hong-Yu
HY
Yang
Ming-Hua
MH
Xu
D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007097:Imines; D007211:Indoles / Q000138:chemical synthesis*; D008722:Methods; D009904:Optical Rotation; D012238:Rhodium
D000588:Amines; D006841:Hydrocarbons, Aromatic; D007097:Imines; D007211:Indoles; D012238:Rhodium