A renewable, chemoselective, and quantitative ligand density microarray for the study of biospecific interactions.
Novel renewable microarray technology has been developed to immobilize and release carbohydrates and proteins from self-assembled monolayers (SAMs) of electroactive quinone-terminated alkanethiolates on gold surfaces. This method may be applied to a variety of research fields for use in biosensor technology and the generation of renewable and tailored microarrays for biospecific cell-based assays.
University of North Carolina at Chapel Hill, Department of Chemistry, Chapel Hill, NC, USA.
Abigail
A
Pulsipher
Muhammad N
MN
Yousaf
D015374:Biosensing Techniques; D002241:Carbohydrates / Q000737:chemistry*; D004563:Electrochemistry; D006046:Gold / Q000737:chemistry; D008024:Ligands; D008567:Membranes, Artificial; D046228:Microarray Analysis / Q000379:methods*; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
D002241:Carbohydrates; D008024:Ligands; D008567:Membranes, Artificial; D011506:Proteins; D006046:Gold