An electrospray/inductively coupled plasma dual-source time-of-flight mass spectrometer for rapid metallomic and speciation analysis. Part 1. Molecular channel characterization.
A new time-of-flight mass spectrometer has been developed that uses an electrospray source and an inductively coupled plasma to extract molecular, atomic, and isotopic information simultaneously from a single sample. This paper will focus on characterization of the ESI channel. Sensitivities are reported for hexadecyltrimethylammonium, tetrahexylammonium, tetraoctylammonium, myoglobin, insulin, cyanocobalamin, leucine enkephalin, and alcohol dehydrogenase. Skimmer-nozzle collisionally induced dissociation is explored for adduct removal and analyte fragmentation on the ESI channel for tetraoctylammonium ion and leucine enkephalin. Long-term and short-term spray stability is also examined.
Duane A
DA
Rogers
Steven J
SJ
Ray
Gary M
GM
Hieftje
D008667:Metalloproteins / Q000737:chemistry*; D058626:Plasma Gases / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods*; D013696:Temperature
D008667:Metalloproteins; D058626:Plasma Gases; D000644:Quaternary Ammonium Compounds