Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling.
In this issue of Molecular Cell, Savir and Tlusty (2010) apply signal detection theory to show that homologous recombination machinery is optimally tuned to find homologous DNA sequences within an exceptionally high background of heterologous sequences.
Life Sciences Division, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Robert P
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Rambo
Gareth J
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Williams
John A
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Tainer