Sleep-related deglutition in patients with OSAHS under CPAP therapy.
CONCLUSIONS
Continuous positive airway pressure (CPAP) therapy improved not only apnea-hypopnea during sleep and sleep structure but also sleep-related deglutition, especially respiratory phase patterns associated with deglutition.


OBJECTIVE
Sleep-related deglutition and related respiratory phase patterns in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) under CPAP therapy were investigated.


METHODS
Deglutition during sleep was examined in 10 patients who had severe OSAHS under CPAP therapy via time-matched recordings of polysomnography and surface electromyography.


RESULTS
The mean number of swallows per hour during the total sleep time was 1.6 ± 1.3. The mean period of the longest absence of deglutition was 66.4 ± 19.6 min. Deglutition was related to the sleep stage. The mean number of swallows per hour was 6.8 ± 8.4 during stage 1 sleep, 1.1 ± 0.8 during stage 2 sleep, 0.1 ± 0.4 during stage 3 sleep, and 0 during stage 4 sleep. The deeper the sleep stage, the lower the mean deglutition frequency. The mean number of swallows per hour was 0.8 ± 0.5 during REM sleep. Most deglutition occurred in association with spontaneous electroencephalographic arousal. Swallows followed by inspiration were markedly reduced. Under CPAP therapy, sleep-related deglutition and its respiratory phase pattern had normalized.
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan. kimisato@oct-net.ne.jp
Kiminori
K
Sato
Hirohito
H
Umeno
Shun-ichi
S
Chitose
Tadashi
T
Nakashima
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D003679:Deglutition / Q000502:physiology*; D004576:Electromyography; D006801:Humans; D007821:Laryngeal Muscles / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010609:Pharyngeal Muscles / Q000503:physiopathology; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D012894:Sleep Stages