Evaluation of an osteostimulative putty in the sheep spine.
The objective of this study is to evaluate local response to a bioactive glass based composite putty (NovaBone Putty) in a vertebral body defect model in sheep, as compared to NovaBone, a bioactive glass particulate. Two time periods were used for the study, 6 and 12 weeks. Empty defects were also used as a control. In comparing the three test groups, the relative amount of new bone for both grafted defects was substantially greater than for the empty controls (P < 0.05). At 6 weeks, the bone formation was 42% for NovaBone Putty, 27% for NovaBone and 1.2% for the ungrafted empty defect. At 12 weeks, the bone formation was 51.4% for NovaBone Putty, 47.3% for NovaBone and 5.1% for the empty defect. NovaBone Putty, the test material, had greater bone content than the NovaBone, both of which were significantly greater than the empty control.
Institute of Orthopedic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China. wangzhen@fmmu.edu.cn
Zhen
Z
Wang
Bin
B
Lu
Lei
L
Chen
Jiang
J
Chang
D020341:Absorbable Implants; D000818:Animals; D001843:Bone Cements / Q000494:pharmacology*; D001846:Bone Development / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D018786:Bone Substitutes / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D048091:Guided Tissue Regeneration / Q000379:methods; D008297:Male; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D012756:Sheep; D013122:Spinal Diseases / Q000473:pathology / Q000601:surgery; D013131:Spine / Q000187:drug effects* / Q000473:pathology / Q000502:physiology / Q000601:surgery
C022107:Bioglass; D001843:Bone Cements; D018786:Bone Substitutes