Interleukin-6: a local pain trigger?
Pain management in conditions of chronic inflammation is a clinical challenge, and increasing our understanding of the mechanisms driving this type of pain is important. In the previous issue of Arthritis Research & Therapy, Boettger and colleagues examine the role of IL-6 in antigen-induced arthritis using the IL-6 neutralizing soluble glycoprotein 130 and link IL-6 to a pathophysiological role in the generation of pain, independent of the proinflammatory properties of IL-6. The findings presented in this study add to a growing body of evidence highlighting the role of IL-6 in the induction and maintenance of pain.
Camilla I
CI
Svensson
D000818:Animals; D001169:Arthritis, Experimental / Q000150:complications / Q000378:metabolism*; D050822:Cytokine Receptor gp130 / Q000378:metabolism / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism*; D010146:Pain / Q000209:etiology / Q000378:metabolism*; D051381:Rats
D015850:Interleukin-6; D050822:Cytokine Receptor gp130