Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
In order to look for novel insecticides targeting the ryanodine receptor, four new series of anthranilic diamides containing modified N-pyridylpyrazoles were designed and synthesized. All of the compounds were characterized and confirmed by (1)H NMR, (13)C NMR, and HRMS. The single crystal structure of 10c was determined by X-ray diffraction. Their insecticidal activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that most of the compounds showed moderate to high activities at the tested concentration, while compound 19 showed comparable higher activity at the concentration of 0.125 mg/L. The preliminary structure-activity relationship (SAR) was discussed.
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Qi
Q
Feng
Zhi-Li
ZL
Liu
Li-Xia
LX
Xiong
Ming-Zhong
MZ
Wang
Yong-Qiang
YQ
Li
Zheng-Ming
ZM
Li
D000818:Animals; D003958:Diamide / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007555:Isoxazoles / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects*; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007306:Insecticides; D007555:Isoxazoles; D011720:Pyrazoles; D003958:Diamide; C033962:anthranil