A catecholamine crisis on Mount Kilimanjaro: a hypoxia effect?
Sympathetic paragangliomas are autonomic nervous system tumors associated with dysregulation of intracellular oxygen metabolism. Exposure to high altitudes is reported to activate the production of catecholamines in the sympathoadrenal system. We describe an individual with a paraganglioma complicated by a catecholamine crisis that occurred on the summit of Mount Kilimanjaro.
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Montserrat
M
Ayala-Ramirez
Mouhammed Amir
MA
Habra
Naifa
N
Busaidy
Gilbert
G
Cote
Thereasa
T
Rich
Steven
S
Waguespack
Camilo
C
Jimenez
D000531:Altitude; D001859:Bone Neoplasms / Q000556:secondary; D002395:Catecholamines; D017809:Fatal Outcome; D006325:Heart Atria / Q000473:pathology*; D006338:Heart Neoplasms / Q000473:pathology; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009647:Normetanephrine / Q000097:blood / Q000652:urine*; D010235:Paraganglioma / Q000150:complications* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013636:Tanzania; D014481:United States
D002395:Catecholamines; D009647:Normetanephrine