[Association between lipoprotein(a) and coronary artery disease].
OBJECTIVE
To explore the correlation between plasma level of lipoprotein(a) [Lp(a)] and coronary artery disease (CAD).


METHODS
A total of 1011 patients underwent coronary angiography in our department from October 2007 to March 2009 due to chest pain were included, 613 cases (60.6%) were diagnosed as CAD and the remaining 398 non-CAD patients (39.4%) served as control. Lp(a), apolipoproteinA1 (apoA1), apolipoproteinB (apoB) were detected by immunoturbidimetry method, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured by enzymatic approach. LDL-C/HDL-C ratio was calculated, multivariate logistic regression analysis was performed.


RESULTS
(1) The values of Lp(a), TG, TC, LDL-C and apoB, and the ratio of LDL-C/HDL-C in CAD group were significantly higher in CAD group [(170.00 ± 160.00) mg/L, (1.84 ± 0.90) mmol/L, (4.86 ± 0.88) mmol/L, (3.31 ± 0.72) mmol/L, (0.97 ± 0.17) mmol/L and 3.39 ± 0.93] compared to those in control group [(120.00 ± 100.00) mg/L, (1.67 ± 0.72) mmol/L, (4.61 ± 0.95) mmol/L, (2.96 ± 0.80) mmol/L, (0.90 ± 0.18) mmol/L and 2.89 ± 0.92, all P < 0.05]. (2) Multivariate logistic regression analysis (forward method) indicated that Lp(a) (OR = 16.201, 95%CI 3.477 - 75.489, P = 0.0001) was the most powerful independent risk factor for diagnosing coronary artery disease.


CONCLUSIONS
Lp(a) is the most powerful independent risk factors for diagnosing coronary artery disease.
Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China.
Guan
G
Wang
Yan-fang
YF
Li
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D014280:Triglycerides / Q000097:blood
D001055:Apolipoproteins B; D017270:Lipoprotein(a); D014280:Triglycerides; D002784:Cholesterol