Effect of omega-3 and vitamin E supplementation on dry mouth in patients with Sjögren's syndrome.
To determine whether omega-3 (n-3) increases saliva production in patients with Sjögren's syndrome, 61 patients with Sjögren's received either wheat germ oil (n = 23) or n-3 supplement (TheraTears Nutrition®) (n = 38) in a prospective, randomized, double-masked trial. The outcomes assessed were salivary secretion and markers for oral inflammation. The differences between the n-3 group and wheat germ oil group were not statistically significant for either unstimulated (US) or stimulated (SS) salivary secretion (p= 0.38 and p= 0.346, respectively) nor for the number of sites with probing depth (PD) ≥ 4 mm (p= 0.834). In this pilot study, supplementation with n-3 was not found to be significantly better than wheat germ oil in stimulating saliva production in patients with Sjögren's syndrome.
Division of Oral Medicine and Dental Research, Tufts University School of Dental Medicine, Boston, Massachusetts, USA. periodok@yahoo.com
Medha
M
Singh
Paul C
PC
Stark
Carole A
CA
Palmer
Jeffrey P
JP
Gilbard
Athena S
AS
Papas
D000368:Aged; D019587:Dietary Supplements; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000008:administration & dosage; D011446:Prospective Studies; D012472:Salivation / Q000187:drug effects; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use*; D014987:Xerostomia / Q000150:complications / Q000188:drug therapy*
D015525:Fatty Acids, Omega-3; D010938:Plant Oils; D014810:Vitamin E; C050055:wheat germ oil