Collagenous repeat-containing sequence of 26 kDa protein - a newly discovered adipokine - sensu lato - A minireview.
BACKGROUND
Increasing evidence from numerous research studies in internal medicine shows that adipocytes and adipokines are involved in primary inflammatory processes and disease. CORS-26 (collagenous repeat- containing sequence of 26 kDa protein) is a newly discovered adipokine of the C1q/TNF molecular superfamily C1q/TNF-related protein-3 (CTRP-3) secreted, inter alia in murine monocytes and adipocytes and in human adipocytes. Reported recently as a gene product of adipocyte differentiation, it shares structural similarity with the adipocyte, adiponectin. CORS-26 is much less known than other adipocytes such as leptin and resistin. Knowledge of its various functions has clinical and therapeutic implications especially in relation to obesity and the metabolic syndrome.


OBJECTIVE
This review aims to provide current knowledge of this adipokine.


METHODS
Review; sources were scientific biomedical databases Medline/PubMed, BioMedCentral, Google Scholar, Ovid, ProQuest from to 1998 to 2009.


CONCLUSIONS
CORS-26 is an adipokine that regulates the secretion of other adipokines. Its effects on adipokine secretion are most probably independent of PPAR-γ. As CORS-26 up-regulates adiponectin secretion, it may be involved in metabolic and immunologic pathways. The effect of recombinant CORS-26 on insulin signaling in the presence of the metabolic syndrome needs to be investigated to further evaluate the physiological and pathophysiological role of this protein.
Department of Laboratory Medicine, Central Moravian District Hospital, Prostejov, Czech Republic.
Marek
M
Svestak
Lenka
L
Sporova
Pavel
P
Hejduk
Borek
B
Lacnak
David
D
Stejskal
D054392:Adipokines / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D020219:Chondrogenesis / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000503:physiopathology; D012516:Osteosarcoma / Q000503:physiopathology; D048069:Tumor Necrosis Factors / Q000502:physiology*; D017539:Tunica Intima / Q000503:physiopathology
D054392:Adipokines; C506069:C1QTNF3 protein, human; D016207:Cytokines; D048069:Tumor Necrosis Factors