Letter to the editor: Panaxadiol's anticancer activity is enhanced by epicatechin.
We previously reported the antiproliferative effect of panaxadiol (PD), an active compound in steamed ginseng, on human HCT-116 colorectal cancer cells, and that antioxidants might play a role in this effect. In this study, we observed that PD's antiproliferative effect was significantly enhanced by epicatechin (EC), a strong natural antioxidant in grape seed. Evidence for the synergistic antiproliferative effect was supported by the remarkable increase in the number of apoptotic cells.
Miguel
M
Rodriguez
Guang-Jian
GJ
Du
Chong-Zhi
CZ
Wang
Chun-Su
CS
Yuan
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry; D002392:Catechin / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D036145:Ginsenosides / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry; D005894:Panax / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D027843:Vitis / Q000737:chemistry
D000975:Antioxidants; D036145:Ginsenosides; D010936:Plant Extracts; C004564:panaxadiol; D002392:Catechin