Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids.
Gastrointestinal (GI) lymphoma is the most frequently diagnosed form of lymphoma in the cat and is categorized into two distinct forms based on the size of neoplastic lymphocytes. Treatments for both large- and small-cell GI lymphoma have been described previously; however, multiple chemotherapy protocols were used, a minimal amount of histopathological characterization was provided, and, in most studies, the majority of diagnoses were obtained via endoscopic pinch biopsies. Twenty-eight cats (24 with full-thickness intestinal biopsies) were diagnosed with small-cell GI lymphoma and treated with a combination of chlorambucil and glucocorticoids. The majority of cases were strongly CD3+, and many displayed epitheliotropism. The overall clinical response rate was 96%, with a median clinical remission duration of 786 days. Follow-up identified seven cats with relapsed disease-all of which were treated with a rescue protocol of cyclophosphamide and glucocorticoids; the response rate was 100%, and four of the 28 cats were diagnosed with a second malignancy.
Departments of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706, USA.
Timothy J
TJ
Stein
Mackenzie
M
Pellin
Howard
H
Steinberg
Ruthanne
R
Chun
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002699:Chlorambucil / Q000627:therapeutic use*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D005938:Glucocorticoids / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000662:veterinary; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D005938:Glucocorticoids; D002699:Chlorambucil