Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.
Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I - pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II - threatened preterm labour patients between 24-34 weeks of gestation; III - preterm vaginal delivery patients; IV - healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery.
Department of Perinatology, Medical University of Białystok, Poland. kucp@poczta.fm
Paweł
P
Kuć
Adam
A
Lemancewicz
Piotr
P
Laudański
Małgorzata
M
Krętowska
Tadeusz
T
Laudański
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007743:Labor, Obstetric / Q000502:physiology*; D008423:Maternal Age; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D007752:Obstetric Labor, Premature / Q000201:enzymology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D014621:Vagina / Q000201:enzymology
D015415:Biomarkers; D020782:Matrix Metalloproteinases; D020784:Matrix Metalloproteinase 8