Helicobacter pylori infection and childhood.
Pediatric-based Helicobacter pylori research continues to contribute significantly to our understanding of both clinical and pathophysiological aspects of this infection. Here, we review the published pediatric H. pylori literature from April 2009-March 2010. Analysis of pediatric H. pylori strains continues to suggest that cagA(+) and cagPAI competent strains are less prevalent than in adult isolates. Studies from the Middle East report a high H. pylori prevalence and intrafamilial transmission. Data continue to show a lack of association between H. pylori and recurrent abdominal pain of childhood, gastroesophageal reflux disease, and growth retardation. Recent probiotic trials have not shown a benefit on H. pylori eradication in children, while sequential therapy remains an attractive therapeutic eradication strategy in children, which requires validation in different geographic regions.
Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands. p.e.c.mourad-baars@lumc.nl
Petronella
P
Mourad-Baars
Séamus
S
Hussey
Nicola L
NL
Jones
D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D044404:Genomic Islands; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000628:therapy / Q000635:transmission; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008877:Middle East / Q000453:epidemiology; D015995:Prevalence; D019936:Probiotics / Q000008:administration & dosage; D016896:Treatment Outcome; D037521:Virulence Factors / Q000235:genetics
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori