Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function.
Myeloid-derived suppressor cells (MDSCs) are one of the main cell populations responsible for regulating immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection and other pathological conditions, and can potently suppress T cell function. Recent studies have demonstrated the ability of MDSCs to modulate the activity of NK and myeloid cells and have implicated MDSCs in the induction of regulatory T cells. Here, we discuss recent findings that describe the molecular mechanisms that regulate the expansion and function of MDSCs, as well as recent attempts to use MDSCs in cell therapy for different pathologic conditions.
H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Fl 33612, USA.
Thomas
T
Condamine
Dmitry I
DI
Gabrilovich
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007108:Immune Tolerance; D008214:Lymphocytes / Q000276:immunology; D022423:Myeloid Cells / Q000166:cytology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors