Immunohistochemical analysis of undifferentiated and poorly-differentiated head and neck malignancies at a tertiary hospital in Nigeria.
This is a retrospective analysis of poorly-differentiated head and neck malignancies at University College Hospital, Ibadan. Eighty-six poorly-differentiated neoplasms were categorized as carcinomas, sarcomas, lymphomas or neuroendocrine cancers with a panel of 7 antibodies (cytokeratin AE1/AE3, vimentin, desmin, myogenin, leukocyte common antigen and neuron-specific enolase). Immunohistochemical and original hematoxylin-eosin diagnoses were contrasted.The male: female ratio was 2.5:1, with mean age of 38.9 years. Nasopharynx, nose and maxillofacial bones were the most common locations. Immunohistochemistry confirmed 54.8% of carcinomas, 70.6% of sarcomas and 80% of lymphomas.Hematoxylin-eosin was able to distinguish between sarcoma and lymphoma but differentiation between a carcinoma and neuroendocrine lesion was poor. Further studies are required to maximize the role of immunohistochemistry as an ancillary diagnostic tool in the West African sub-region.
Department of Oral Pathology, University College Hospital, Ibadan, Oyo State, Nigeria. perakin80@hotmail.com
Akinyele O
AO
Adisa
Abideen O
AO
Oluwasola
Bukola F
BF
Adeyemi
Bamidele
B
Kolude
Effiong Eu
EE
Akang
Jonathan O
JO
Lawoyin
D000328:Adult; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006785:Hospitals, University; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008223:Lymphoma / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D009549:Nigeria; D012509:Sarcoma / Q000175:diagnosis / Q000378:metabolism*; D012680:Sensitivity and Specificity