Subcutaneous panniculitis-like T-cell lymphoma in a child with trisomy 21.
Subcutaneous Panniculitis-Like T-cell Lymphoma (SPTCL) is a rare lymphoma with fewer than twenty cases reported in children less than 18 years of age. Trisomy 21 is a chromosomal abnormality associated with a risk of malignancy that differs from their normal counterparts. Leukemia is diagnosed 10-20 times over the general population while solid tumors are underrepresented. The risk for Lymphoma historically has been elevated as well. We describe a case of a 3 year-old girl with Down syndrome who was successfully treated for SPTCL.
Department of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, Tennessee 37232, USA. avery.mixon@vanderbilt.edu
Benjamin
B
Mixon
Laura
L
Drach
Hector
H
Monforte
Jerry
J
Barbosa
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D004314:Down Syndrome / Q000150:complications*; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications; D015434:Panniculitis / Q000150:complications; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone