Effect of systane and optive on aqueous tear evaporation in patients with dry eye disease.
OBJECTIVE
To compare the effect on aqueous tear (AT) evaporation rate of Systane and Optive at 30 min postinstillation in patients with dry eye.


METHODS
In a crossover study of 20 patients with keratoconjunctivitis sicca, the evaporation rate of AT was measured. Evaporometry was used at two relative humidity (RH) ranges of 25% to 35% and 35% to 45%. The measurements were made at baseline (before the instillation of the study agent) and at 30 min after the instillation of 40 μL of either Systane or Optive per randomization assignment per visit with a 1-week interval between visits.


RESULTS
No significant effects on AT evaporation rates at both RHs were found between study agents.


CONCLUSIONS
In our study, neither Systane nor Optive has a significant impact on AT evaporation at 30 min postinstillation in patients with dry eye.
Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA.
Jadwiga C
JC
Wojtowicz
Juan C
JC
Arciniega
James P
JP
McCulley
V Vinod
VV
Mootha
D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D006813:Humidity; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000737:chemistry* / Q000627:therapeutic use*; D014835:Volatilization; D055815:Young Adult
D009883:Ophthalmic Solutions