Platelet- and megakaryocyte-derived microparticles.
Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.
Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. rflaumen@bidmc.harvard.edu
Robert
R
Flaumenhaft
Albert T A
AT
Mairuhu
Joseph E
JE
Italiano
D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure*; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008533:Megakaryocytes / Q000378:metabolism / Q000648:ultrastructure*