Cell signaling.
This review explores advances in our understanding of dynamicism in cellular signaling. Areas highlighted include the role of stochasticity in producing diversity in analogous signaling circumstances; population desynchronization's effect in masking newly appreciated repetitive bursts in protein phosphorylation and messenger RNA production; double-positive feedback interactions and their ability to synchronize multiple signal transduction pathways; scaffolding proteins control over signaling feedback; and frequency-responsive transcriptional regulation as an example of dynamicism in signaling.
Department of Animal Biology, University of Pennsylvania Veterinary School, Philadelphia, Pennsylvania, USA. drjamesiqbal@gmail.com
Jameel
J
Iqbal
Mone
M
Zaidi
Narayan G
NG
Avadhani
D000818:Animals; D002468:Cell Physiological Phenomena / Q000502:physiology*; D045604:Extracellular Fluid / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D012333:RNA, Messenger