Importance of controlling drug-resistant Pseudomonas aeruginosa infection: experience from lung transplantation in a cystic fibrosis case.
Cystic fibrosis (CF) is rare in Japan. We encountered a CF case with drug-resistant Pseudomonas aeruginosa infection and successfully performed lung transplant from living related donors. A combination of beta-lactams and aminoglycosides for drug-resistant P. aeruginosa infection was administered before lung transplantation. Intravenous colistin was also used immediately before and after transplant surgery. Gram staining of respiratory specimens was performed every day after surgery and it was useful in monitoring infection status. Strict monitoring of infections by the Gram staining and culture of respiratory specimens is considered to be effective in preventing lower respiratory infection in lung transplantation.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki. yyamamo@nagasaki-u.ac.jp
Yoshihiro
Y
Yamamoto
Koichi
K
Izumikawa
Atsuko
A
Hara
Hanako
H
Fujita
Misato
M
Amenomori
Noriho
N
Sakamoto
Masafumi
M
Seki
Hiroshi
H
Kakeya
Katsunori
K
Yanagihara
Kenji
K
Takasaki
Takuro
T
Miyazaki
Tomoshi
T
Tsuchiya
Naoya
N
Yamasaki
Tsutomu
T
Tagawa
Takeshi
T
Nagayasu
Shigeru
S
Kohno
D000617:Aminoglycosides / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D024881:Drug Resistance, Bacterial; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects; D008297:Male; D011552:Pseudomonas Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D055815:Young Adult; D018440:beta-Lactam Resistance; D047090:beta-Lactams / Q000627:therapeutic use
D000617:Aminoglycosides; D047090:beta-Lactams