Locally synthesized HSP27 in hepatocytes: Is it possibly a novel strategy against human liver ischemia/reperfusion injury?
Ischemia/reperfusion injury (IRI) is a common complication after liver surgery. Approximately 10% of grafts lose function in the early stage after liver transplantation. However, there is no effective way against IRI yet. Heat shock protein 27 (HSP27), a member of the heat shock protein families, is recognized as a protective factor against liver IRI recently. Studies showed that HSP27 can lessen the induction of proinflammatory messenger, reduce neutrophil infiltration, decrease apoptosis (caspase 3 fragmentation and DNA laddering), and reduce disruption of filamentous actin. In addition, Kupffer cells inhibitor- gadolinium chloride can reduce lipid peroxidation and promote hepatocytes regeneration. Herein, we hypothesize that transfecting liver with HSP27 gene accompanied by gadolinium chloride might be a potentially novel treatment against IRI. Compared to passive defense, we firstly suggest positive protection against ischemia/reperfusion injury by hepatocytes automatically.
Key Laboratory of Combined Multi-Organ Transplantation, Minstry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Sun-yi
SY
Ye
Jian
J
Wu
Jun
J
Zhang
Shu-sen
SS
Zheng
D000199:Actins / Q000378:metabolism; D017209:Apoptosis; D002460:Cell Line; D005682:Gadolinium / Q000494:pharmacology; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D007728:Kupffer Cells / Q000166:cytology; D015227:Lipid Peroxidation; D008099:Liver / Q000473:pathology*; D008954:Models, Biological; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*
D000199:Actins; D055551:HSP27 Heat-Shock Proteins; D005682:Gadolinium; C038958:gadolinium chloride