[Effect of nifedipine on electrophysiological properties of rat ureter spontaneous activity].
The work studied effect of various concentrations of nifedipine on the slow and fast spontaneous activities evoked in the perivesical and perirenal areas of the rat ureter. Whereas in the proximal zone of the organ at the low dose of nifedipine (0.06 and 0.12 mg/kg), inhibition is revealed both of slow waves and of their corresponding spikes, in the perivesical part the opposite effect is observed. Besides, with further increase of the nifedipine dose to 0.15 and 0.2 mg/kg, in the ureter area adjacent to the urinary bladder, alongside with acceleration of slow pacemaker oscillations, the appearance of the antiperistaltically directed action potentials is also possible.
K V
KV
Kazarian
V Ts
VTs
Vantsian
L G
LG
Simonian
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001683:Biological Clocks / Q000187:drug effects* / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D014513:Ureter / Q000502:physiology*
D002121:Calcium Channel Blockers; D009543:Nifedipine