Proposed revision to the radiation dosimetry of 82Rb.
Three models for the biodistribution and dosimetry of 82Rb-chloride were reviewed and a proposal is made for the best dosimetry for this agent to be adopted. Data from three proposed biokinetic models for 82Rb-chloride were used to calculate dose estimates for the compound, and the results were compared. The blood content-based model was found to produce dose estimates that were considered to be overly conservative, and a blood flow-based model, which showed good agreement with available measured data, was considered to be more reasonable. A new set of dose estimates for 82Rb-chloride, based on the blood flow-based kinetic model are suggested for general use.
RADAR Task Group of Society of Nuclear Medicine, and Vanderbilt University, Nashville, TN 37232-2675, USA. michael.g.stabin@vanderbilt.edu
Michael G
MG
Stabin
D000465:Algorithms; D002712:Chlorides / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods* / Q000592:standards; D012413:Rubidium / Q000097:blood / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002712:Chlorides; D012413:Rubidium; C032710:rubidium chloride