Histological fate of abdominal dermis-fat grafts implanted in the temporomandibular joint of the rabbit following condylectomy.
The histological fate of abdominal dermis-fat grafts implanted into the temporomandibular joint (TMJ) following condylectomy was studied. 21 rabbits underwent left TMJ discectomies and condylectomies; 6 were controls (Group A; no graft used); 15 (Group B) had autogenous abdominal grafts transplanted into the left TMJ. Animals were killed after 4, 12 and 20 weeks. Specimens of the TMJ were histologically and histomorphometrically evaluated. At 4 weeks, fat necrosis was clear in all specimens. The dermis component survived and formed cysts with no necrosis. By 12 weeks, viable fat deposits appeared with no evidence of necrotic fat. At 20 weeks, large amounts of viable fat were present in Group B specimens. Group A had no fat, although the missing condyles regenerated. In the presence of viable fat, Group B showed little condyle regeneration 20 weeks after condylectomy. Non-vascularised fat grafts do not survive transplantation, but stimulate neoadipogenesis. The fate of the dermis component of the graft is independent of the fat component. Fat in the joint space disrupts the regeneration of a new condylar head. Neoadipogensis inhibits growth of new bone and cartilage. This has clinical implications for TMJ ankylosis management and preventing heterotopic bone formation around prosthetic joints.
Department of Surgery, St. Vincent's Hospital, The University of Melbourne, Melbourne, Australia. geodim25@gmail.com
G
G
Dimitroulis
J
J
Slavin
W
W
Morrison
D000005:Abdomen / Q000601:surgery; D050156:Adipogenesis; D000818:Animals; D000844:Ankylosis / Q000517:prevention & control; D001861:Bone Regeneration; D020405:Dermis / Q000637:transplantation*; D005218:Fat Necrosis; D005260:Female; D006085:Graft Survival; D008335:Mandibular Condyle / Q000502:physiology / Q000601:surgery*; D009999:Ossification, Heterotopic / Q000517:prevention & control; D011817:Rabbits; D050507:Subcutaneous Fat, Abdominal / Q000637:transplantation*; D013704:Temporomandibular Joint / Q000601:surgery*; D019224:Temporomandibular Joint Disc / Q000601:surgery; D020858:Tissue and Organ Harvesting