Endoscopic embolization with onyx prior to resection of JNA: a new approach.
OBJECTIVE
To report a novel pioneering approach of endoscopic embolization (EE) and resection of juvenile nasopharyngeal angiofibroma (JNA) and describe all outcomes and results.


METHODS
Four patients presented to the University of Miami with repeated episodes of unilateral epistaxis diagnosed by fiberoptic and radiographic examination as nasal JNA. Subsequently, in conjunction with neurosurgery, endoscopic visualization was provided to perform intratumor needle insertion, through which the liquid embolic agent Onyx was infused to embolize the JNA's under fluoroscopic and endoscopic guidance. The day after EE, endoscopic resection was performed. Operating room time, estimated blood loss (EBL), and other intraoperative and post-operative results are reported and compared to published literature.


RESULTS
A total of 4 patients (all males), had EE of JNA and subsequent endoscopic resection between September 2008 and January 2009. Average EBL during surgery was 412.5 ml (range 150-800) with an average operating room time of 228 min (range 95-485). We experienced no bleeding from the tumor or its attachments, only from the approach. Two patients experienced mild numbness in the V2 distribution, which began to resolve one week post-operatively. No other complications were encountered.


CONCLUSIONS
This is the first published report of direct endoscopic embolization of JNA with Onyx. Although further studies are needed, it seems to provide a safe, less invasive alternative to traditional embolization and endoscopic resection, but must be done in cooperation with interventional neurosurgery to maximize its safety profile.
Department of Otolaryngology, University of Miami School of Medicine, Miami, FL 33136, USA.
Björn
B
Herman
Michael
M
Bublik
Jose
J
Ruiz
Ramzi
R
Younis
D000293:Adolescent; D018322:Angiofibroma / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy / Q000379:methods; D004621:Embolization, Therapeutic / Q000379:methods*; D004724:Endoscopy / Q000379:methods*; D004844:Epistaxis / Q000175:diagnosis / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000628:therapy*; D011145:Polyvinyls / Q000494:pharmacology*; D018570:Risk Assessment; D012494:Sampling Studies; D016896:Treatment Outcome
D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer