Enantioselective Friedel-Crafts alkylation of indole derivatives catalyzed by new Yb(OTf)3-pyridylalkylamine complexes as chiral Lewis acids.
New Yb(OTf)(3)-pyridylalkylamine complexes have been employed as chiral Lewis acids in the enantioselective Friedel-Crafts alkylation of indole derivatives with trifluoropyruvates. The influence of the substituents as well as the configuration of the ligands have been studied and allowed us to reach enantiomeric excesses up to 83%.
Université de Versailles-Saint-Quentin, Institut Lavoisier de Versailles UMR CNRS 8180, 45, avenue des États-Unis, 78035 Versailles Cedex, France.
Guillaume
G
Grach
Aurelia
A
Dinut
Sylvain
S
Marque
Jérôme
J
Marrot
Richard
R
Gil
Damien
D
Prim