Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France.
A total of 657 sputum samples from 201 cystic fibrosis adult patients were collected during a 24-month period (2005-2006). We retrospectively analyzed the fungal colonization of the respiratory tract of these individuals by linking medical records and microbiological data. Filamentous fungi were isolated from specimens of 65.6% of the patients, with Aspergillus fumigatus being the predominant species recovered as it was found in specimens of 56.7% of the patients. We observed no difference for gender, pancreatic status and cirrhosis in patients with or without A. fumigatus colonization. We found a higher percentage of recovery of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and nontuberculous mycobacteria in patients with A. fumigatus colonization. During the follow-up period of the study, 8.9% of the patients were diagnosed with allergic bronchopulmonary aspergillosis (ABPA). By a multivariate analysis we demonstrated that Scedosporium apiospermum was significantly associated with ABPA (Odds ratio = 13 [2-80]) as opposed to A. fumigatus (Odds ratio = 1.58 [0.49-5.05]).
Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, France. andre.paugam@cch.aphp.fr
André
A
Paugam
Marie-Thérèse
MT
Baixench
Nadine
N
Demazes-Dufeu
Pierre-Régis
PR
Burgel
Elise
E
Sauter
Reem
R
Kanaan
Daniel
D
Dusser
Jean
J
Dupouy-Camet
Dominique
D
Hubert
D000293:Adolescent; D000328:Adult; D000368:Aged; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000453:epidemiology / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000145:classification / Q000302:isolation & purification; D003550:Cystic Fibrosis / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D005602:France / Q000453:epidemiology; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D021681:Scedosporium / Q000145:classification / Q000302:isolation & purification; D013183:Sputum / Q000382:microbiology*; D055815:Young Adult