Is male infertility a forerunner to cancer?
OBJECTIVE
The frequency of testicular cancer and male infertility has been increasing in the past several decades. This article examines the relationship between male infertility and testicular cancer, concentrating particularly on causal links.


RESULTS
Both of these disorders are associated with testicular dysgenesis syndrome and have also been traced to mutations in genes involving DNA repair and tumor suppression, as well as environmental exposure.


CONCLUSIONS
The identification and examination of these common points of origin supports the integration of testicular cancer screenings into the routine evaluation of infertile men.
Center for Reproductive Medicine, Glickman Urological, Cleveland, Ohio 44195, USA.
Whitney R
WR
Burns
Edmund
E
Sabanegh
Rima
R
Dada
Brandon
B
Rein
Ashok
A
Agarwal
D002278:Carcinoma in Situ / Q000235:genetics*; D006059:Gonadal Dysgenesis / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000235:genetics*