Inactivation of Ascaris suum by short-chain fatty acids.
Ascaris suum eggs were inactivated in distilled water and digested sludge by butanoic, pentanoic, and hexanoic acids. The fatty acids (short-chain fatty acids [SCFA]) were effective only when protonated and at sufficient concentrations. The conjugate bases were not effective at the concentrations evaluated. Predictions from an inhibition model (50% inhibitory concentration [IC(50)]) based on quantitative structure-activity relationships were congruent with inactivation data.
Department of Geography and Environmental Engineering, US Military Academy, West Point, New York 10996, USA.
Michael A
MA
Butkus
Kelly T
KT
Hughes
Dwight D
DD
Bowman
Janice L
JL
Liotta
Michael B
MB
Jenkins
Michael P
MP
Labare
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D017165:Ascaris suum / Q000187:drug effects*; D002087:Butyrates / Q000494:pharmacology*; D002208:Caproates / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D010421:Pentanoic Acids / Q000494:pharmacology*
D000871:Anthelmintics; D002087:Butyrates; D002208:Caproates; D010421:Pentanoic Acids; C037652:hexanoic acid