5-Androstene-3β,7β,17β-triol (β-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosis.
5-Androstene-3β,7β,17β-triol (β-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs). In a murine thermal injury model that includes glucocorticoid-induced osteopenia, β-AET significantly (p<0.05) preserved bone mineral content, restored whole body bone mineral content and endochondral growth, suggesting reversal of GC-mediated decreases in chondrocyte proliferation, maturation and osteogenesis in the growth plate. In men and women, levels of β-AET decline with age, consistent with a role for β-AET relevant to diseases associated with aging. β-AET, related compounds or synthetic derivatives may be part of effective therapeutic strategies to accelerate tissue regeneration and prevent or treat diseases associated with aging such as osteoporosis.
Harbor Biosciences, Inc., San Diego, California, United States of America.
Ajay K
AK
Malik
Sophia
S
Khaldoyanidi
Dominick L
DL
Auci
Scott C
SC
Miller
Clarence N
CN
Ahlem
Christopher L
CL
Reading
Theodore
T
Page
James M
JM
Frincke
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000737:Androstenols / Q000494:pharmacology*; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology*; D002056:Burns / Q000150:complications / Q000503:physiopathology*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D010024:Osteoporosis / Q000503:physiopathology*
C108492:5-androstene-3,7,17-triol; D000737:Androstenols