Convergent assembly of structurally diverse quinazolines.
A convergent and versatile Vilsmeier-Haack-based carbo-annulation strategy that exhibits an unusually elevated bond-forming efficiency has been developed. By virtue of its innovative approach, structure economy and simple execution conditions the methodology reported here constitutes a very attractive protocol that enables the rapid assembly of structurally diverse quinazoline chemotypes.
Combinatorial Chemistry Unit (COMBIOMED), Institute of Industrial Pharmacy (IFI), University of Santiago de Compostela, Santiago de Compostela 15782, Spain.
Abel
A
Crespo
Alberto
A
Coelho
Paula M
PM
Diz
Franco
F
Fernández
Hector
H
Novoa de Armas
Eddy
E
Sotelo
D000470:Alkaloids / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry*
D000470:Alkaloids; D011799:Quinazolines