Early postoperative bleeding in polytrauma patients treated with fondaparinux: literature review and institutional experience.
Surgery for pelvic or acetabular fractures carries a high risk of deep-vein thrombosis (DVT). Reports indicate that fondaparinux is a more effective thromboprophylactic agent than low molecular weight heparin (LMWH) after major orthopaedic surgery. The safety and efficacy of fondaparinux was evaluated in a new protocol used for DVT prophylaxis. One hundred and twenty seven patients with pelvic or acetabular fractures received either fondaparinux or enoxaparin and were analysed in a historical non-concurrent study. Specific review points included clinical deep-vein thrombosis (DVT) or pulmonary embolism (PE) and evidence of adverse effects such as bleeding or allergic reactions. Two patients that received enoxaparin were found to have a DVT and one patient had a PE. There was no documented DVT or PE in patients that received fondaparinux. The mean number of units of blood transfused postoperatively was higher in the enoxaparin group; however, multivariate regression modelling demonstrated no significant difference between the groups. The most current large randomised controlled studies investigating the administration of fondaparinux following joint arthroplasty or hip fracture surgery, have demonstrated a slight increase or a similar number of bleeding events in patients treated with fondaparinux when compared to those treated with enoxaparin. The current report supports that fondaparinux, in patients with pelvic and acetabular fractures, can be equally effective as enoxaparin and not associated with adverse bleeding events.
Academic Department of Trauma and Orthopaedics, University of Leeds, School of Medicine, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Clarendon Wing A, Great George Street, Leeds, LS1 3EX, UK.
Eleftherios
E
Tsiridis
Zakareya
Z
Gamie
Marc J
MJ
George
Daisy
D
Hamilton-Baille
Robert M
RM
West
Peter V
PV
Giannoudis
D000077:Acetabulum / Q000293:injuries / Q000601:surgery; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D017984:Enoxaparin / Q000627:therapeutic use; D005260:Female; D000077425:Fondaparinux; D050723:Fractures, Bone / Q000601:surgery; D006801:Humans; D008297:Male; D019637:Orthopedic Procedures / Q000009:adverse effects; D010384:Pelvic Bones / Q000293:injuries / Q000601:surgery; D011134:Polysaccharides / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000517:prevention & control; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000517:prevention & control; D014947:Wounds and Injuries / Q000097:blood / Q000601:surgery*
D000925:Anticoagulants; D017984:Enoxaparin; D011134:Polysaccharides; D000077425:Fondaparinux