Sry: the master switch in mammalian sex determination.
SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development.
Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Kenichi
K
Kashimada
Peter
P
Koopman
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D005812:Genes, Switch; D008297:Male; D008322:Mammals / Q000235:genetics*; D008954:Models, Biological; D019849:Sex Determination Processes / Q000235:genetics*; D051876:Sex-Determining Region Y Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D051876:Sex-Determining Region Y Protein