Two novel alkaloids from the South China Sea marine sponge Dysidea sp.
Two new alkaloids, dysideanins A (1) and B (2), along with two known diketopiperazines, cyclo-(Pro-Leu) (3) and cyclo-(Pro-Ile) (4), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B (2) exhibited antibacterial activity. The thiomethylated imidazolinium unit as found in dysideanin A is very rarely encountered in nature.
Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Shen
S
Ren
Wei
W
Ma
Tunhai
T
Xu
Xiuping
X
Lin
Hao
H
Yin
Bin
B
Yang
Xue-Feng
XF
Zhou
Xian-Wen
XW
Yang
Lijuan
L
Long
Kyung Jin
KJ
Lee
Qipin
Q
Gao
Yonghong
Y
Liu
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D047088:Dysidea / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D007093:Imidazoles; D010880:Piperidines