Increases in use of methotrexate since the 1980s.
In this chapter, we review the use of DMARDs in several clinical RA cohorts and databases between the 1970s and the 2000s. The DMARD profile in the QUEST-RA database provides an overview of clinical use of MTX in recent years in 25 countries. The data show that (I) MTX is currently the most frequently used DMARD in RA, and (II) that this development has taken about 20 years to emerge.
Jyväskylä Central Hospital, Jyväskylä, Finland. tuulikki.sokka@ksshp.fi
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D018501:Antirheumatic Agents / Q000266:history / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000266:history; D019992:Databases as Topic; D004363:Drug Utilization; D017723:Drug Utilization Review; D019317:Evidence-Based Medicine; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008727:Methotrexate / Q000266:history / Q000627:therapeutic use*; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D008727:Methotrexate