Omni-Stat (Chitosan) arrests bleeding in heparinised subjects in vivo: an experimental study in a model of major peripheral vascular injury.
OBJECTIVE
To explore the effectiveness of Omni-Stat (Chitosan) in a model of major haemorrhage in the presence of clotting dysfunction.


METHODS
A total of 12 major femoral artery bleeds in moderately heparinised swine treated with Omni-Stat (Chitosan) were compared with five control bleeds.


RESULTS
Haemostasis was successfully achieved at first treatment in 10 of 12 bleeds and at second treatment in the remaining two bleeds.


CONCLUSIONS
The study supports the evidence that Omni-Stat (Chitosan) acts independently of classical clotting pathways and should be effective in patients with clotting dysfunctions, who suffer major haemorrhage. It also suggests the potential for a role in cardiac surgery.
Department of Cardiothoracic Surgery, Blackpool Victoria Hospital Whinney Heys Road, Blackpool, FY3 8NR, UK. mr.millner@bfwhospitals.nhs.uk
Russell W J
RW
Millner
Alan S
AS
Lockhart
Rebecca
R
Marr
Keith
K
Jones
D000818:Animals; D000925:Anticoagulants / Q000633:toxicity; D048271:Chitosan / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D005263:Femoral Artery / Q000293:injuries*; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006493:Heparin / Q000633:toxicity; D008297:Male; D034421:Sus scrofa; D057772:Vascular System Injuries / Q000150:complications*
D000925:Anticoagulants; D006490:Hemostatics; D006493:Heparin; D048271:Chitosan