[Pathogenesis of aspirin-induced gastric mucosal injury].
It is necessary for some conditions to occur at the same time so that aspirin induced gastric mucosa injury occurs. The definite condition that is necessary for the development of gastric mucosa injury by aspirin is the direct injury with the aspirin and the presence of the gastric acid. The pathologic central mechanism is the inhibition of cyclooxygenase, the disturbance of microcirculation and pro-apoptotic signaling. At all events, it is a theme for gastroenterologists to establish a mean to prevent the gastric mucosa injury induced by aspirin.
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine.
Yuji
Y
Naito
Toshikazu
T
Yoshikawa
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin