Cardiovascular diseases after kidney transplantation in Korea.
Cardiovascular disease (CVD) is the leading cause of death in renal allograft recipients with functioning graft. Our study aimed to determine the incidence and the risk factors of cardiovascular disease after renal transplantation in Korea. We retrospectively analyzed 430 adult recipients who underwent kidney transplantation between January 1997 and February 2007. CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease. Mean age of recipients was 40.0±11.8 yr. Mean duration of follow-up was 72±39 months. The cumulative incidence of CVD after renal transplantation was 2.4% at 5 yr, 5.4% at 10 yr and 11.4% at 12 yr. Multivariate analysis revealed that recipient's age, diabetes mellitus and duration of dialysis before transplantation were associated with post-transplant CVD (hazard ratio 1.843 [95% CI, 1.005-3.381], 3.846 [95% CI, 1.025-14.432] and 3.394 [95% CI, 1.728-6.665] respectively). In conclusion, old age, duration of dialysis and diabetes mellitus are important risk factors for post-transplant CVD, although the incidence of post-renal transplant CVD is lower in Korea than that in western countries.
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Jong Cheol
JC
Jeong
Han
H
Ro
Young-Hwan
YH
Hwang
Han Kyu
HK
Lee
Jongwon
J
Ha
Curie
C
Ahn
Jaeseok
J
Yang
D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D006435:Renal Dialysis; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors