Beneficial effects of dienogest on uterine myoma volume: a retrospective controlled study comparing with gonadotropin-releasing hormone agonist.
OBJECTIVE
Uterine leiomyomas are the most common benign tumors of reproductive age women, but there is no effective medical therapy to data. Aim of this study was to examine and compare the efficacy of gonadotropin-releasing hormone agonist (GnRHa) versus dienogest in premenopausal women with uterine myoma.


METHODS
We retrospectively analyzed the medical records of 55 premenopausal patients with endometriosis, who received dienogest (2 mg daily) for 6 months regarding coexistence of uterine myoma between January 2008 and June 2010. To compare these data in a case-control study, we analyzed a matched control group of 12 patients treated with leuprolide acetate (1.88 mg monthly) for 6 months having uterine myoma.


RESULTS
Of the 55 patients treated with dienogest, six were associated with coexistent myoma node. Total myoma volume significantly decreased to 59.7 ± 7.0% of initial in dienogest group and 51.9 ± 5.5% in GnRHa group. Reduction rate in myoma volume was similar in both groups.


CONCLUSIONS
Uterine myoma volume was successfully reduced by use of dienogest. Consideration of GnRHa disadvantages may lead to short- or long-term management of women with myoma who are to be managed transiently, and who wish to avoid surgical intervention, especially perimenopausal women.
Department of Obstetrics and Gynecology, Matsunami General Hospital, Gifu 501-6062, Japan.
Satoshi
S
Ichigo
Hiroshi
H
Takagi
Kazutoshi
K
Matsunami
Noriko
N
Suzuki
Atsushi
A
Imai
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D016022:Case-Control Studies; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016729:Leuprolide / Q000627:therapeutic use*; D008875:Middle Aged; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017697:Premenopause; D012189:Retrospective Studies; D047368:Tumor Burden / Q000187:drug effects*; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
D018931:Antineoplastic Agents, Hormonal; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; C023635:dienogest; D009277:Nandrolone; D016729:Leuprolide