Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis.
OBJECTIVE
To investigate whether the clinical history, particularly of the adolescence period, contains markers of deeply infiltrating endometriosis (DIE).


METHODS
Cross-sectional study.


METHODS
Universitary tertiary referral center.


METHODS
Two hundred twenty-nine patients operated on for endometriosis. Endometriotic lesions were histologically confirmed as non-DIE (superficial peritoneal endometriosis and/or ovarian endometriomas) (n = 131) or DIE (n = 98).


METHODS
Surgical excision of endometriotic lesions with pathological analysis of each specimens.


METHODS
Epidemiological data, pelvic pain scores, family history of endometriosis, absenteeism from school during menstruation, oral contraceptive (OC) pill use.


RESULTS
Patients with DIE had significantly more positive family history of endometriosis (odds ratio [OR] = 3.2; 95% confidence interval [CI]: 1.2-8.8) and more absenteeism from school during menstruation (OR = 1.7; 95% CI: 1-3). The OC pill use for treating severe primary dysmenorrhea was more frequent in patients with DIE (OR = 4.5; 95% CI: 1.9-10.4). Duration of OC pill use for severe primary dysmenorrhea was longer in patients with DIE (8.4 ± 4.7 years vs. 5.1 ± 3.8 years). There was a higher incidence of OC pill use for severe primary dysmenorrhea before 18 years of age in patients with DIE (OR = 4.2; 95% CI: 1.8-10.0).


CONCLUSIONS
The knowledge of adolescent period history can identify markers that are associated with DIE in patients undergoing surgery for endometriosis.
Faculté de Médecine, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Ouest, Centre Hospitalier, Paris, France. charles.chapron@cch.aphp.fr
Charles
C
Chapron
Marie-Christine
MC
Lafay-Pillet
Elise
E
Monceau
Bruno
B
Borghese
Charlotte
C
Ngô
Carlos
C
Souza
Dominique
D
de Ziegler
D000041:Absenteeism; D000293:Adolescent; D016497:Adolescent Health Services; D000328:Adult; D003276:Contraceptives, Oral / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D004715:Endometriosis / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D005192:Family Health; D005260:Female; D006801:Humans; D008487:Medical History Taking / Q000706:statistics & numerical data*; D008599:Menstruation Disturbances / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D017699:Pelvic Pain / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
D003276:Contraceptives, Oral