Methylphenidate increases choice of cigarettes over money.
BACKGROUND
Stimulants increase cigarette smoking in the naturalistic environment and laboratory. The effects of methylphenidate on a 9-trial, discrete cigarette versus money ($0.25) choice task were tested to elucidate the mechanisms underlying stimulant-induced increases in smoking.


METHODS
Eleven participants who reported smoking 10-20 cigarettes/day completed the study. Four doses of methylphenidate (0, 10, 20, and 40 mg) were administered across 5 experimental sessions, with placebo administered twice. One hour following medication administration and at 30-min intervals thereafter, participants chose between smoking a cigarette and receiving US$0.25. The primary behavioral outcome measure was number of cigarette choices.


RESULTS
Methylphenidate increased the number of cigarette choices over money. Puffs per session and carbon monoxide levels increased significantly and caloric intake decreased significantly following methylphenidate administration relative to placebo.


CONCLUSIONS
The results of this study suggest that methylphenidate increases the relative reinforcing efficacy of cigarette smoking. Stimulant use may thus be an important consideration for individuals attempting to quit smoking.
Department of Behavioral Science, University of Kentucky College of Medicine, 140 Medical Behavioral Science Building, Lexington, KY 40536-0086, USA.
William W
WW
Stoops
Mégan M
MM
Poole
Andrea R
AR
Vansickel
Kathryn A
KA
Hays
Paul E A
PE
Glaser
Craig R
CR
Rush
D000328:Adult; D002248:Carbon Monoxide / Q000097:blood; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D010919:Placebos; D012907:Smoking; D055815:Young Adult
D000697:Central Nervous System Stimulants; D010919:Placebos; D008774:Methylphenidate; D002248:Carbon Monoxide