High resolution in vivo micro-CT with flat panel detector based on amorphous silicon.
A high-resolution in vivo micro-CT system for combining with fluorescence molecular tomography (FMT), was constructed and applied in small animal imaging. The fast scanning micro-CT system designed to provide high-resolution anatomic information and reconstruction priors, consisted of a flat panel detector (FPD) based on amorphous silicon (a-Si) and a micro-focus x-ray tube. The Feldkamp algorithm was adopted in image reconstruction with graphic processing unit (GPU). The system spatial resolution of 13 lp/mm was achieved when the diameter of image field was 6 cm with the system magnification factor of 4. No obvious beam hardening artifact was observed in transaxial image of a water phantom after correction. The contrast-to-noise ratio (CNR) study of various tissue phantoms was also presented. The in-vivo imaging of an anesthetic mouse was performed to demonstrate the feasibility of our system.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, PR China.
Xiaoquan
X
Yang
Yuanzheng
Y
Meng
Qingming
Q
Luo
Hui
H
Gong
D000465:Algorithms; D000818:Animals; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D019047:Phantoms, Imaging; D012825:Silicon / Q000737:chemistry*; D012886:Skull / Q000000981:diagnostic imaging; D013131:Spine / Q000000981:diagnostic imaging; D051598:Whole Body Imaging / Q000379:methods; D055114:X-Ray Microtomography / Q000295:instrumentation / Q000379:methods*
D012825:Silicon