Effects of simvastatin on relapse and remodeling of periodontal tissues after tooth movement in rats.
BACKGROUND
Our objectives were to determine the effects of simvastatin on relapse and periodontal tissue remodeling after experimental tooth movement in rats and to explore the molecule mechanism.


METHODS
Thirty-two adult male Wistar rats were randomly divided into 2 groups. Bilateral mandibular first molars were moved mesially with nickel-titanium closed-coil springs in both groups. On the 21st day, the springs were removed, and dental casts were made. Animals in the experimental group began receiving simvastatin at a dose of 2.5 mg per kilogram per day for 4 weeks, and animals in the control group received 0.9% sodium chloride. The results were evaluated by model measuring and immunohistochemistry staining.


RESULTS
Relapse distances and relapse percentages were decreased in the simvastatin group compared with the controls. Osteoprotegerin expression increased, and RANKL decreased.


CONCLUSIONS
These results indicate that simvastatin inhibits the bone-resorbing activity of osteoclasts while stimulating bone formation, probably by controlling the ratio of local osteoprotegerin to RANKL in the periodontal tissues. Therefore, it might be useful for retention.
Department of Endodontics, School of Stomatology, JiLin University, Changchun, China.
Guanghong
G
Han
Yuanping
Y
Chen
Jianhua
J
Hou
Chang
C
Liu
Chong
C
Chen
Jinliang
J
Zhuang
Wei
W
Meng
D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology; D003765:Models, Dental; D008963:Molar / Q000187:drug effects / Q000473:pathology; D009969:Orthodontic Wires; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D053244:Osteoprotegerin / Q000187:drug effects; D010513:Periodontal Ligament / Q000187:drug effects / Q000473:pathology; D010519:Periodontium / Q000187:drug effects* / Q000473:pathology; D053245:RANK Ligand / Q000037:antagonists & inhibitors; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D019821:Simvastatin / Q000494:pharmacology*; D013314:Stress, Mechanical; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000295:instrumentation / Q000379:methods*
D050071:Bone Density Conservation Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D053244:Osteoprotegerin; D053245:RANK Ligand; C506032:Tnfrsf11b protein, rat; D019821:Simvastatin