Safety of recombinant human thrombopoietin in adults after related donor haploidentical haematopoietic stem cell transplantation: a pilot study.
OBJECTIVE
Delayed recovery of platelets can be found in recipients of related donor haploidentical haematopoietic stem cell transplantation (HSCT). The objective of this study was to evaluate the safety of recombinant human thrombopoietin (rhTPO) administration prior to engraftment in patients who received related donor haploidentical HSCT.


METHODS
Nineteen patients with haematological malignancies received rhTPO prior to platelet engraftment after related donor haploidentical HSCT. Safety and tolerability levels together with the influence of rhTPO on the outcome of transplantation were evaluated.


RESULTS
Slight elevations in ALT and/or AST were observed in five patients; in two other patients, bilirubin levels increased slightly. No significant changes in routine examination findings and no allergic reactions were observed during the study period. Eighteen patients achieved platelet engraftment at a median of 16 (range 11-34) days. The cumulative ± SD incidence of acute graft-versus-host disease (GVHD) grade 1-4 at +100 days was 68.4 ± 10.7%, and that of chronic GVHD at 3 years was 24.7 ± 10.7%. Nine (47.4%) patients survived free of relapse, with a median follow-up of 1631 (1550-1734) days after transplantation.


CONCLUSIONS
Early administration of rhTPO prior to engraftment was safe and well tolerated in patients receiving related donor haploidentical HSCT.
People's Hospital Peking University, Institute of Hematology, Xicheng District, Beijing, People's Republic of China.
Dai-Hong
DH
Liu
Xiao-Jun
XJ
Huang
Kai-Yan
KY
Liu
Lan-Ping
LP
Xu
Yu-Hong
YH
Chen
Yu
Y
Wang
Wei
W
Han
Huan
H
Chen
D000328:Adult; D005260:Female; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D019520:Living Donors; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects; D008875:Middle Aged; D010865:Pilot Projects; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D013926:Thrombopoietin / Q000008:administration & dosage / Q000009:adverse effects*; D019172:Transplantation Conditioning
D011994:Recombinant Proteins; D013926:Thrombopoietin