Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.
Hexane, chloroform and ethyl acetate extracts (100 microg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani. Twelve compounds namely, methyleugenol (1), p-coumaryl diacetate (2), 1'-acetoxychavicol acetate (3), 1'-acetoxyeugenol acetate (4), trans-p-acetoxycinnamyl alcohol (5), trans-3,4-dimethoxycinnamyl alcohol (6), p-hydroxybenzaldehyde (7), p-hydroxycinnamaldehyde (8), trans-p-coumaryl alcohol (9), galangin (10), trans-p-coumaric acid (11) and galanganol B (12) were isolated from these extracts. Of these, compounds 2, 3, 4 and 5 were found most active in vitro against promastigotes of L. donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 microM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga.
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, 160 062, India.
Amandeep
A
Kaur
Ranvir
R
Singh
Chinmoy Sankar
CS
Dey
Shyam Sundar
SS
Sharma
Kamlesh K
KK
Bhutani
Inder Pal
IP
Singh
D000085:Acetates / Q000737:chemistry; D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002725:Chloroform / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005054:Eugenol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006586:Hexanes / Q000737:chemistry; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011422:Propionates; D027343:Rhizome / Q000737:chemistry
D000085:Acetates; D000981:Antiprotozoal Agents; D003373:Coumaric Acids; D005419:Flavonoids; D006586:Hexanes; D010936:Plant Extracts; D011422:Propionates; C037032:galangin; D005054:Eugenol; C057996:1'-acetoxyeugenol; C007650:ethyl acetate; D002725:Chloroform; C495469:p-coumaric acid