High-protein diet suppresses corpus atrophic gastritis in Helicobacter pylori infected Mongolian gerbils.
To investigate the effect of a high-protein diet on corpus atrophic gastritis in Helicobacter pylori-infected Mongolian gerbils, H. pylori was administered orally to 5-wk-old Mongolian gerbils; and the animals were then fed a control diet (Group C); a high-fat diet (Group F: 40% fat); a high-protein diet (Group P: 32% protein); or a high-fat, high-protein diet (Group FP: 40% fat, 32% protein) for 50 wk beginning at 7 wk of age. In uninfected animals, the mucosal thickness of the corpus was significantly greater in Group P and Group FP than in Group C (P < 0.05). In infected animals, the serum gastrin level was significantly decreased in Group FP and marginally significantly decreased in Group P (P = 0.057) in comparison to Group C. The mucosal thickness of the corpus was significantly greater in Group P and Group FP than in Group C (P < 0.05). Mean inflammation and atrophy scores in the corpus were significantly lower in the high-protein groups (Groups P and FP) than in the control groups (Groups C and F; both inflammation and atrophy: P < 0.05). In conclusion, long-term administration of a high-protein diet suppresses corpus atrophic gastritis in H. pylori-infected Mongolian gerbils.
Kawasaki University of Medical Welfare, Okayama, Japan.
Keiko
K
Shinozaki
Tomoari
T
Kamada
Kuniaki
K
Sugiu
Hiroaki
H
Kusunoki
Noriaki
N
Manabe
Akiko
A
Shiotani
Jiro
J
Hata
Fusako
F
Teramoto
Ken
K
Haruma
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001835:Body Weight; D002364:Caseins / Q000627:therapeutic use; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage*; D005748:Gastric Fundus / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000209:etiology / Q000517:prevention & control*; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000097:blood / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology; D008297:Male; D008679:Metaplasia; D009929:Organ Size; D012720:Severity of Illness Index; D013047:Specific Pathogen-Free Organisms; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000517:prevention & control
D000907:Antibodies, Bacterial; D002364:Caseins; D004041:Dietary Fats; D004044:Dietary Proteins; D005755:Gastrins