Apoptosis: opening PANdora's BoX.
Extracellular nucleotides have been reported to act as a 'find-me' signal in the context of phagocyte recruitment by apoptotically dying cells. A new study now examines the mechanisms of nucleotide release during apoptosis and describes the hemichannel-forming protein pannexin 1 as a crucial player in this scenario.
Dept. of Internal Medicine I, Eberhard-Karls-University of Tuebingen, Otfried-Mueller-Str. 10, D-72076 Tuebingen, Germany.
Christoph
C
Peter
Sebastian
S
Wesselborg
Kirsten
K
Lauber
D000255:Adenosine Triphosphate / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology; D017630:Connexins / Q000502:physiology*; D006801:Humans; D019169:Jurkat Cells; D009419:Nerve Tissue Proteins / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010586:Phagocytes / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D014544:Uridine Triphosphate / Q000378:metabolism*
D017630:Connexins; D009419:Nerve Tissue Proteins; C492764:PANX1 protein, human; D000255:Adenosine Triphosphate; D014544:Uridine Triphosphate