The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia.
BACKGROUND
Interleukin-15 (IL-15) plays important roles in the immune system and in the development of hematopoietic cells. Previous studies revealed that five SNPs in IL-15, rs10519612, rs10519613, rs35964658, rs17007695 and rs17015014, were significantly associated with childhood Acute Lymphoblastic Leukemia (ALL) treatment response. In adult ALL, the expression of IL-15 was also correlated with the immunophenotypes of ALL. Therefore, we hypothesize that SNPs of IL-15 might also be associated with adult ALL.


RESULTS
We genotyped the above five SNPs of IL-15 gene by PCR-RFLP assays in adult ALL case-control studies. The current study included 121 adult ALL patients and 263 healthy controls. IL-15 genotypes and haplotypes were determined and the associations with the risk of ALL were analyzed by logistic regression. SNPs rs10519612 and rs17007695 were significantly associated with ALL (P = 0.013 and P = 0.001). We observed a 2-fold and 2.4-fold excess risk of developing ALL for the rs10519612 CC and rs17007695 TC genotype carriers compared with non-carriers, respectively. Haplotype analysis revealed that haplotypes ACAC, CAGT and CCAT were significantly associated with adult B-ALL, while haplotype CCAT conferred susceptibility to T-ALL.


CONCLUSIONS
These findings suggest that IL-15 gene polymorphisms are significantly associated with ALL in adult Chinese population.
Laboratory of Cellular and Molecular Tumor Immunology, Cyrus Tang Hematology Center, Department of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, China.
Dandan
D
Lin
Chunliang
C
Liu
Mengxing
M
Xue
Rengyun
R
Liu
Lan
L
Jiang
Xiao
X
Yu
Guangming
G
Bao
Fang
F
Deng
Mingjie
M
Yu
Jiafu
J
Ao
Yifeng
Y
Zhou
Depei
D
Wu
Haiyan
H
Liu
D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015848:Interleukin-5 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D017931:DNA Primers; D015848:Interleukin-5