Direct patterning of silanized-biomolecules on semiconductor surfaces.
A novel approach to pattern silanized-biomolecules directly onto glass (SiO(x)) substrates via Dip-Pen nanolithography (DPN) and microcontact printing (μCP) is presented. Subsequent hybridization reactions of DPN patterned silanized-DNA with its complementary strands provide "proof-of-concept" that the patterned oligonucleotides maintain their biological activities. The fabrication strategy does not require premodification of substrates and offers a cheap and robust way to immobilize molecules on electronically important semiconductor surfaces.
The Department of Chemistry, Loyola University Chicago, 1068 West Sheridan Road, Chicago, Illinois 60626, United States.
Dorjderem
D
Nyamjav
Richard C
RC
Holz
D001672:Biocompatible Materials / Q000737:chemistry*; D002384:Catalysis; D002621:Chemistry / Q000379:methods; D004247:DNA / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000379:methods; D008856:Microscopy, Fluorescence / Q000379:methods; D008956:Models, Chemical; D036103:Nanotechnology / Q000379:methods; D009841:Oligonucleotides / Q000737:chemistry*; D017646:Organosilicon Compounds; D011506:Proteins / Q000737:chemistry; D012666:Semiconductors; D012821:Silanes / Q000737:chemistry*
D001672:Biocompatible Materials; D009841:Oligonucleotides; D017646:Organosilicon Compounds; D011506:Proteins; D012821:Silanes; C102833:(3-mercaptopropyl)trimethoxysilane; D004247:DNA