Malignant prolactinoma: a rare case report.
Pituitary carcinomas are rare adenohypophyseal tumors with cerebrospinal or extracranial metastasis. None of the histologic findings distinguish pituitary adenoma from carcinoma. We describe clinico-pathological and immunohistological features of malignant prolactinoma. The patient initially presented with a prolactin-secreting pituitary adenoma. The tumor showed aggressive clinical course presenting with repeated recurrences and eventually metastasized to multiple bones. MIB-1 and p53 labeling indices were also compared in primary adenoma, recurrent invasive adenoma and metastatic tumor.
Department of Pathology, Gujarat Cancer and Research Institute (M. P. Shah Cancer Hospital), Ahmedabad, Gujarat, India. priti_patho@yahoo.co.in
Priti
P
Trivedi
Anuja
A
Gupta
Sunil
S
Pasricha
Dipak
D
Patel
D000328:Adult; D000974:Antibodies, Antinuclear / Q000378:metabolism; D000911:Antibodies, Monoclonal / Q000378:metabolism; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000473:pathology*; D015175:Prolactinoma / Q000473:pathology*; D013125:Spinal Neoplasms / Q000556:secondary*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; C440408:MIB-1 antibody; D016159:Tumor Suppressor Protein p53