GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase.
Adipokines produced from adipose tissues participate in regulation of reproduction, energy homeostasis, food intake, and neuroendocrine function in the hypothalamus. We have previously reported that adiponectin significantly reduced GnRH secretion from GT1-7 hypothalamic GnRH neuron cells. In this study, we further investigated the inhibition of GnRH secretion by adiponectin in vivo and found that extracellular signal-regulated kinase (ERK) was inhibited and AMPK activated. Furthermore, we found that activated AMPK by adiponectin reduced ERK phosphorylation, which possibly impaired GnRH secretion in GT1-7 cells.
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Key Laboratory of Endocrine and Metabolic Diseases of Chinese Health Ministry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiao-Bing
XB
Cheng
Jun-Ping
JP
Wen
Jun
J
Yang
Ying
Y
Yang
Guang
G
Ning
Xiao-Ying
XY
Li
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D052242:Adiponectin / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D004789:Enzyme Activation / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D052242:Adiponectin; D047428:Protein Kinase Inhibitors; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D048049:Extracellular Signal-Regulated MAP Kinases; D055372:AMP-Activated Protein Kinases