Whole ovary transplantation.
Several strategies have been developed in an attempt to preserve fertility in these women, including ovarian transplantation. The current protocols of ovarian transplantation require transplanting fresh or cryopreserved-thawed ovarian cortical strips in an orthotopic or heterotopic location. The main limitation of this approach is the limited longevity of graft function because of the posttransplantation ischemic injury. Whole ovary cryopreservation with its' vascular pedicle with subsequent transplantation with a vascular anastomosis is one experimental approach to minimize the effects of ischemic damage including whole ovary transplantation.
Department of Obstetrics-Gynecology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Mohamed A
MA
Bedaiwy
Tommaso
T
Falcone
D000975:Antioxidants / Q000494:pharmacology; D015925:Cryopreservation; D005260:Female; D006062:Gonadotropins / Q000494:pharmacology; D006085:Graft Survival; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D007511:Ischemia / Q000517:prevention & control; D009369:Neoplasms / Q000150:complications; D018919:Neovascularization, Physiologic; D010053:Ovary / Q000637:transplantation*
D000975:Antioxidants; D006062:Gonadotropins; D036341:Intercellular Signaling Peptides and Proteins