A novel program to accurately quantify infarction volume by (99m)Tc MIBI SPECT, and its application for re-analyzing the effect of erythropoietin administration in patients with acute myocardial infarction.
BACKGROUND
This study aimed to apply a software to calculate myocardial infarction (MI) volume by single-photon emission computed tomography.


RESULTS
The cardioVol software has been developed to reconstruct 3D figures from sequential short axis images. We re-analyzed the data from the EPO/AMI-I Study. The MI volume at baseline correlated with maximum creatine kinase. The MI volume significantly decreased during the 6-month follow up in the erythropoietin (EPO) group, but not in the control group. The decrements of MI volume in the EPO group were significantly larger than those in the control group.


CONCLUSIONS
The efficacy of EPO was further confirmed by the software.
Division of Radiation Oncology, Niigata University Medical and Dental Hospital, Niigata, Japan.
Norihiko
N
Yoshimura
Ken
K
Toba
Takuya
T
Ozawa
Yoshifusa
Y
Aizawa
Tetsuo
T
Hosoya
D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / Q000379:methods*; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy; D015609:Organotechnetium Compounds / Q000008:administration & dosage*; D010865:Pilot Projects; D011859:Radiography; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012984:Software
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D004921:Erythropoietin