Trends in the incidence and management of biliary tract cancer: a French population-based study.
OBJECTIVE
The trends in incidence and management of biliary tract cancer (BTC) were investigated in a well-defined French population over a 30-year period (1976-2005).


METHODS
Data were obtained from the Burgundy digestive cancer registry. Age-standardised incidence rates and trends in incidence were determined. Treatment and stage at diagnosis were also investigated. Five-year survival rates were calculated.


RESULTS
Six hundred and fifteen cases of BTC were recorded. There was no significant change in BTC incidence over the 30-year period. For extrahepatic BTC age-standardised incidence rates were 1.1/100,000 for 1976-80 and 2001-2005. These rates were respectively 0.3 and 0.2/100,000 for intrahepatic BTC. The proportion of patients undergoing resection for cure increased over time from 4.8% to 14.2% (p<0.001). The proportion of stage I-II cases ranged from 3.2% to 7.1% but did not vary significantly over time (p=0.55). Most cases were metastatic or unresectable at diagnosis. Five-year relative survival rates were 4.5% for 1976-85 and 6.7% for 1996-2005, ranging from 35.1% for stages I-II to 4.3% for advanced BTC. Age and stage at diagnosis were independent prognostic factors.


CONCLUSIONS
The incidence of BTC has remained stable in Burgundy over the past 30 years. BTC prognosis remains poor and has only improved slightly over time.
Registre Bourguignon des Cancers Digestifs, INSERM U866, Université de Bourgogne, Dijon, France. come.lepage@u-bourgogne.fr
Côme
C
Lepage
Vanessa
V
Cottet
Marion
M
Chauvenet
Jean-Marc
JM
Phelip
Laurent
L
Bedenne
Jean
J
Faivre
Anne-Marie
AM
Bouvier
D000368:Aged; D001661:Biliary Tract Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009367:Neoplasm Staging; D015996:Survival Rate; D013997:Time Factors