Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: clinical, cytogenetic, and molecular findings.
Primary lung tumors are rare in children, and mucoepidermoid carcinoma (MEC) represents less than 10% of them. Additionally, MEC arising from bronchogenic cysts (BC) is particularly unusual. We describe the clinical and genetic findings on a MEC occurring within a previous location of a BC in an adolescent. This particular association has not been previously reported. The lesion revealed normal karyotype without the typical t(11;19)(q21;p13) translocation. Cyclin D1 overexpression (165-fold increase) was demonstrated by real-time PCR although FISH assessment showed normal hybridization at 11q13. Information on these unusual clinical presentations may present relevant insight on tumorigenesis of infrequent pediatric pulmonary tumors.
Division of Pediatric Oncology, University of São Paulo, Brazil. marsol@rge.fmrp.usp.br
María Sol
MS
Brassesco
Elvis Terci
ET
Valera
Régia Caroline Peixoto
RC
Lira
Lídia Alice Gomes M
LA
Torres
Carlos Alberto
CA
Scrideli
Jorge
J
Elias
Sara Reis
SR
Teixeira
Luiz Gonzaga
LG
Tone
D000293:Adolescent; D001994:Bronchogenic Cyst / Q000150:complications* / Q000503:physiopathology; D018277:Carcinoma, Mucoepidermoid / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D019938:Cyclin D1 / Q000096:biosynthesis; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D020133:Reverse Transcriptase Polymerase Chain Reaction
D019938:Cyclin D1