Characterization of the chemically deposited hydroxyapatite coating on a titanium substrate.
Bioactive hydroxyapatite (HA) coating on titanium (Ti) implant can be used as a drug delivery device. A controlled release of drug around the implant requires the incorporation of drug into the coating material during the coating process. HA coating was prepared using a two-step procedure in conditions suitable for simultaneous incorporation of the protein-based drug into the coating material. Monetite coating was deposited on Ti substrate in acidic condition followed by the transformation of the monetite coating to HA. X-ray diffraction (XRD) confirmed the formation of the monetite phase at the first step of the coating preparation, which was transformed into HA at the second step. Fourier transform infrared spectroscopy demonstrated typical bands of a crystallized carbonated HA with A- and B-type substitution, which was confirmed by the XRD refinement of the structural parameters. Scanning electron microscope was used to observe the morphology of monetite and HA coatings. Adhesion of the coatings was measured using a scratch tester. The critical shearing stress was found to be 84.20 ± 1.27 MPa for the monetite coating, and 44.40 ± 2.39 MPa for the HA coating.
Faculty of Pharmacy, University of Sydney, New South Wales, Australia. alexander.zavgorodniy@sydney.edu.au
Alexander V
AV
Zavgorodniy
Oscar
O
Borrero-López
Mark
M
Hoffman
Racquel Z
RZ
Legeros
Ramin
R
Rohanizadeh
D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage / Q000493:pharmacokinetics; D020099:Coated Materials, Biocompatible / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D017886:Durapatite / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics; D055119:Elastic Modulus; D004595:Electroplating / Q000379:methods; D006245:Hardness Tests; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism; D014961:X-Ray Diffraction
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D017886:Durapatite; D014025:Titanium