Uterine artery Doppler in first-trimester pregnancy screening.
Uterine artery Doppler velocimetry has revolutionized the investigation of the developing placental vasculature. Abnormal placental vascular development is the basis of common obstetric disorders such as preeclampsia and intrauterine growth restriction. Uterine artery Doppler velocimetry by itself or in combination with other biochemical markers seems to be an effective first-trimester screening tool for preeclampsia and in particular early-onset preeclampsia. The diagnostic accuracy although statistically significant, is not as high for the prediction of intrauterine growth restriction unrelated to preeclampsia. In the future, first-trimester prophylaxis using antiplatelet agents in Doppler identified high-risk groups could suppress the development of these disorders.
Department of Ob/Gyn, Wayne State University, Detroit, Michigan, USA. rbahados@med.wayne.edu
Ray O
RO
Bahado-Singh
Cristiano
C
Jodicke
D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis; D037161:Galectins / Q000097:blood; D006801:Humans; D007223:Infant; D007265:Inhibins / Q000097:blood; D010920:Placenta / Q000098:blood supply; D011225:Pre-Eclampsia / Q000175:diagnosis; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging*
D015415:Biomarkers; D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins; D007265:Inhibins; D011266:Pregnancy-Associated Plasma Protein-A