The homodimeric GBS1074 from Streptococcus agalactiae.
ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure.
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England.
Anshuman
A
Shukla
Mark
M
Pallen
Mark
M
Anthony
Scott A
SA
White
D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D016680:Genome, Bacterial; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D055672:Static Electricity; D013292:Streptococcus agalactiae / Q000737:chemistry* / Q000235:genetics; D040681:Structural Homology, Protein
D001426:Bacterial Proteins