The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2.
The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Nicola
N
Philpott
Thomas
T
Bakken
Christopher
C
Pennell
Liwei
L
Chen
Jie
J
Wu
Mark
M
Cannon
D020816:Amino Acid Motifs; D002460:Cell Line; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000378:metabolism*; D020349:Surface Plasmon Resonance
C115448:G protein-coupled receptor, Human herpesvirus 8; D019707:Receptors, Chemokine; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11