Structure of Plasmodium falciparum ADP-ribosylation factor 1.
Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s.
University of Alabama at Birmingham, Birmingham, AL 35294, USA.
William J
WJ
Cook
Craig D
CD
Smith
Olga
O
Senkovich
Anthony A
AA
Holder
Debasish
D
Chattopadhyay
D020823:ADP-Ribosylation Factor 1 / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000201:enzymology*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D040681:Structural Homology, Protein
D020823:ADP-Ribosylation Factor 1