The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression.
An acute LPS challenge immediately following day 1 of shuttlebox training triggered exacerbated central IL-1β production and disrupted memory consolidation and/or further acquisition of the task in 18-month-old mice, compared to 4-month-old controls. These deficits cannot be attributed to alterations in sickness behavior. The findings suggest that age and immune activation combine to impair learning and memory consolidation processes, and that increased central IL-1β production may play a role.
Department of Psychology, Texas Christian University, Fort Worth, TX 76129, USA.
Andrew J
AJ
Tarr
Kristina A
KA
McLinden
Dinko
D
Kranjac
Rachel A
RA
Kohman
Wellington
W
Amaral
Gary W
GW
Boehm
D000367:Age Factors; D000375:Aging; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003072:Cognition Disorders / Q000139:chemically induced*; D004924:Escape Reaction / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000378:metabolism
D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D012333:RNA, Messenger