Tubular aggregate myopathy: a phenotypic spectrum and morphological study.
Tubular aggregates (TAs) are inclusions described in skeletal muscle in a variety of disorders. In a retrospective analysis, TAs were found in 18 (0.24%) cases and involved a spectrum of clinical phenotypes. Ultrastructurally, four distinct types of aggregates were noted. There was no correlation between the clinical phenotypes, duration of illness and types of TAs.
Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Amrita
A
Ghosh
Gayathri
G
Narayanappa
Arun B
AB
Taly
Yasha T
YT
Chickbasavaiya
Anita
A
Mahadevan
Santosh
S
Vani
Nalini
N
Atchayaram
Ishani
I
Mohapatra
Krishna Shankar
KS
Susarala
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D020914:Myopathies, Structural, Congenital / Q000473:pathology* / Q000503:physiopathology*; D009243:NAD / Q000378:metabolism; D010641:Phenotype; D012189:Retrospective Studies; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D009243:NAD; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases