Injectability of silicone oil-based tamponade agents.
OBJECTIVE
High viscosity silicone oils are used as tamponade agents to increase the resistance to emulsification; however, this makes the oils more difficult to inject. Increasing the extensional viscosity is one way to reduce emulsification. This study aimed to evaluate how silicone oils with increased extensional viscosity behave in terms of their ease of injection.


METHODS
The shear viscosity and the length of time taken to inject 9 ml of Siluron 1000, Siluron 2000, Siluron 5000, SiliconMate, a 56/44 w/w blend of Siluron 1000/Siluron 5000 (Blend A) and a 90/10 w/w blend of Siluron 1000/PDMS 423kDa molecular weight (Blend B) were examined.


RESULTS
The shear viscosity of Siluron 1000, Siluron 2000 and Siluron 5000 were within the expected ranges. The shear viscosity of Blend A was 2283 mPa s, Blend B was 4710 mPa s and SiliconMate was 995.3 mPa s. Siluron 1000 and SiliconMate had the shortest injection times as expected due to their lower shear viscosities. Comparison of Siluron 2000 and Blend A demonstrated that Siluron 2000 was easier to inject. Similarly, Blend B was easier to inject than Siluron 5000.


CONCLUSIONS
Silicone oil blends containing small percentages of a high molecular weight additive are easier to inject than single grade oils of the equivalent shear viscosity.
Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, Liverpool, UK. rlw@liverpool.ac.uk
R L
RL
Williams
M J
MJ
Day
M J
MJ
Garvey
G
G
Morphis
C
C
Irigoyen
D
D
Wong
T
T
Stappler
D004655:Emulsions; D006801:Humans; D056965:Injections, Intraocular / Q000295:instrumentation*; D008970:Molecular Weight; D012827:Silicone Oils / Q000008:administration & dosage* / Q000737:chemistry*; D014783:Viscosity
D004655:Emulsions; D012827:Silicone Oils