Murine cecal patch M cells transport infectious prions in vivo.
We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.
School of Veterinary Medicine and Science, University of Nottingham, United Kingdom. n.foster@nottingham.ac.uk
Neil
N
Foster
Gordon G
GG
Macpherson
D000818:Animals; D002432:Cecum / Q000166:cytology* / Q000276:immunology*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010581:Peyer's Patches / Q000502:physiology*; D011328:Prions / Q000378:metabolism*
D011328:Prions