The RecQ DNA helicases in DNA repair.
The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.
Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032, USA. kab2142@columbia.edu
Kara A
KA
Bernstein
Serge
S
Gangloff
Rodney
R
Rothstein
D001419:Bacteria / Q000201:enzymology*; D004260:DNA Repair; D004194:Disease / Q000235:genetics; D042822:Genomic Instability; D006801:Humans; D053484:RecQ Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D053484:RecQ Helicases