Comparison of phase-shifting techniques for in vivo full-range, high-speed Fourier-domain optical coherence tomography.
Single spectrometer-based complex conjugate artifact removal methods are evaluated for in vivo imaging with complementary metal-oxide semiconductor line scan camera based high-speed Fourier-domain optical coherence tomography (FD-OCT) at 100,000 axial scans per second. Performance of three different phase-shifting methods with the same OCT engine is evaluated using modified data acquisition schemes, depending on the requirements of each phase-shifting technique. The suppression ratio of complex conjugate artifact images using a paperboard is assessed for all tested methods. Several other characteristics, including a list of additional hardware requirements (beyond standard FD-OCT components) and data acquisition schemes for each of the methods is presented. In vivo full-range images of human fingerpad and nail are shown and compared with standard FD-OCT images. Additionally, a complex-conjugate-free human retinal volume acquired at the speed of 100,000 A-scans/s is presented.
University of California Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616, USA.
Dae Yu
DY
Kim
John S
JS
Werner
Robert J
RJ
Zawadzki
D000465:Algorithms; D003941:Diagnostic Techniques, Ophthalmological / Q000706:statistics & numerical data; D005385:Fingers / Q000033:anatomy & histology; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D055620:Optical Phenomena; D012160:Retina / Q000033:anatomy & histology; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data