Association between adiponectin and low-grade albuminuria is BMI-dependent in type 2 diabetes.
OBJECTIVE
Low-grade albuminuria is a marker of increased risk for both cardiovascular and renal disease. Adiponectin, with its insulin-sensitizing, anti-inflammatory and antiatherogenic properties, is associated with cardiovascular as well as renal disease. Limited and conflicting data exist on the association of adiponectin with low-grade albuminuria. Our aim was to explore the association of plasma adiponectin and low-grade albuminuria in patients with type 2 diabetes. Furthermore, we were interested whether this association is dependent upon insulin sensitivity.


METHODS
In this cross-sectional study, plasma adiponectin and urinary albumin excretion rate (UAER) were determined in 71 patients by radioimmunoassay. Insulin sensitivity was measured by hyperinsulinemic euglycemic clamp and expressed as the M value. The relationship between variables was described using univariate and multiple linear regression.


RESULTS
Adiponectin and UAER were negatively associated (R = -0.285, p < 0.05) only in patients with BMI >25. The association was independent of the clamp-derived M value, gender, BMI, arterial pressure or cholesterol.


CONCLUSIONS
In obese patients with type 2 diabetes, there is an inverse association between adiponectin and low-grade albuminuria, the association being independent of insulin resistance. The consequences of such a relationship in terms of renal disease progression and cardiovascular survival remain to be evaluated.
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Ljubljana, Slovenia. drazenka.pongrac@gmail.com
Drazenka Pongrac
DP
Barlovic
Jelka
J
Zaletel
Janez
J
Prezelj
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis*; D015992:Body Mass Index; D002318:Cardiovascular Diseases; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications; D012307:Risk Factors
D052242:Adiponectin