An efficient synthesis of 3-substituted indole derivates under ultrasound irradiation.
A solvent-free procedure for the synthesis of 3-substituted indole derivates from indoles and nitroalkenes under ultrasound irradiation is described. Control experiments disclosed besides mechanical effects, namely agitation, sonochemical effects are the main forces to drive the reaction. In the method, 2-chloroethanol was used to prepare a wide variety of 3-substituted indole derivates. This procedure only need equimolar amounts of reaction substrates and can be readily scaled up.
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Zhengyan
Z
Fu
Huawu
H
Shao
D000475:Alkenes / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D014465:Ultrasonics
D000475:Alkenes; D007211:Indoles