Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata.
Investigation of Pimelea elongata ("Lakebed Pimelea") afforded 18 tigliane- and daphnane-type diterpenes (1-18). Eight of these were new compounds: four (1-3, 5) tigliane esters and four (7, 8, 10, 11) daphnane orthoesters. The 10 known compounds were 12-O-decanoylphorbol-13-acetate (4), P. simplex subtoxin B (6), wikstroelide E (9), pimelotides A and B (12, 13), gnidiglaucin (14), simplexin (15), huratoxin (16), kirkinine D (17), and 12-β-acetoxyhuratoxin (18). The structures and relative configurations of the new compounds were determined by 1D and 2D NMR spectroscopic studies in combination with MS analyses.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Patricia Y
PY
Hayes
Sharon
S
Chow
Michael J
MJ
Somerville
Mary T
MT
Fletcher
James J
JJ
De Voss
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004952:Esters; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D029645:Thymelaeaceae / Q000737:chemistry*
D004224:Diterpenes; D004952:Esters