Association of multiple myeloma with different neoplasms: systematic analysis in consecutive patients with myeloma.
Multiple myeloma (MM) has been suggested to be associated with different neoplasms. Of 589 consecutive patients with MM, 59 (10%) had different neoplasms: solid tumors in 78% and hematological neoplasms in 22%. Different neoplasms were separated into those emerging prior or synchronously (p/s; n = 41) versus subsequently after the MM (n = 18). The rate of different neoplasms at the time of MM diagnosis was estimated as 6.6%, and estimated different neoplasm rates at 2, 5, and 10 years were 7.8%, 10.3%, and 11.6%, respectively. Patients with MM with p/s different neoplasms showed a hazard ratio (HR) for impaired overall survival of 1.2 (95% CI 0.8-2.0), whereas in those with subsequent neoplasms the HR was 2.5 (95% CI 1.4-4.4). This demonstrates that (1) p/s are more frequent compared with subsequent different neoplasms, and (2) the prognosis is more impaired with subsequent different neoplasms. Age ≥60 years was a confounding covariable with a HR of 2.021 (95% CI 1.6-2.6).
Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany.
Jens
J
Hasskarl
Gabriele
G
Ihorst
David
D
De Pasquale
Percy
P
Schröttner
Alf
A
Zerweck
Ralph
R
Wäsch
Monika
M
Engelhardt
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors