Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers.
The fatal neurological disorder Alzheimer's disease has been linked to soluble neurotoxic oligomers of amyloid-β (Aβ) peptides. Herein we demonstrate that Cu(1+) ligated within Aβ(42) oligomers (Aβ sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA) possesses a highly dioxygen sensitive tetrahedral coordination geometry. The biological implications of these findings are discussed.
Department of Chemistry, University of Nevada, Reno, NV 89557, USA. shearer@unr.edu
Jason
J
Shearer
Paige E
PE
Callan
Thao
T
Tran
Veronika A
VA
Szalai
D000595:Amino Acid Sequence; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D056928:X-Ray Absorption Spectroscopy / Q000379:methods*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D008024:Ligands; D003300:Copper