PRL-3 phosphatase and cancer metastasis.
The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed.
Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos, Singapore 138648, Republic of Singapore.
Abdul Qader O
AQ
Al-Aidaroos
Qi
Q
Zeng
D054637:Dual-Specificity Phosphatases; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D009363:Neoplasm Proteins; D054637:Dual-Specificity Phosphatases; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases