Emerging roles for XBP1, a sUPeR transcription factor.
X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of homeostasis in the endoplasmic reticulum (ER) and activation of the unfolded protein response (UPR). XBP1, first identified as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells, represents the most conserved signaling component of UPR and is critical for cell fate determination in response to ER stress. Here we review recent advances in our understanding of this multifaceted transcription factor in health and diseases.
Graduate Program in Genetics and Development, Cornell University, Ithaca, NY 14853, USA.
Yin
Y
He
Shengyi
S
Sun
Haibo
H
Sha
Ziying
Z
Liu
Liu
L
Yang
Zhen
Z
Xue
Hui
H
Chen
Ling
L
Qi
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004194:Disease; D006262:Health; D006801:Humans; D007109:Immunity / Q000276:immunology; D008969:Molecular Sequence Data; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D056811:Unfolded Protein Response; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human