Platelet and Erythrocyte Volume and Count: Epidemiological Predictors of Impedance Measured ADP-Induced Platelet Aggregation in Whole Blood.
Variation in the threshold dose of ADP necessary to induce platelet aggregation in whole blood is significantly related to constituent factors of whole blood among 242 men from the Caerphilly Collaborative Heart Disease Study. Increased platelet count, mean platelet volume, and primary ADP-induced aggregation in platelet rich plasma are associated with lower ADP threshold doses, while increased red cell count and mean corpuscular volume are associated with higher ADP threshold doses. Marginal relations involving plasma fibrinogen concentration completely disappear upon taking into account the platelet indices. The platelet indices also appear to mediate relations between the ADP threshold dose and smoking status. Limitations in the data do not allow a more thorough assessment of how such constituents may mediate a relation between ADP threshold dose and past myocardial infarction. However, the analyses do not discount such an association for the platelet indices.
Formerly MRC Epidemiology Unit (South Wales), Llandough Hospital, Penarth, South Glamorgan, CF64 1XW, UK.
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Sharp
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Bath
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Martin
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Beswick
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Sweetnam