Peptide-mediated cancer targeting of nanoconjugates.
Targeted use of nanoparticles in vitro, in cells, and in vivo requires nanoparticle surface functionalization. Moieties that can be used for such a purpose include small molecules as well as polymers made of different biological and organic materials. Short amino acid polymers, peptides, can often rival target binding avidity of much larger molecules. At the same time, peptides are smaller than most nanoparticles and thus allow for multiple nanoparticle modifications and creation of pluripotent nanoparticles. Most nanoparticles provide multiple binding sites for different cargo and targeting peptides which can be used for the development of novel approaches for cancer targeting, diagnostics, and therapy. In this review, we will focus on peptides which have been used for the preparation of different nanoparticles designed for cancer research.
Department of Radiation Oncology, Feinberg School of Medicine and Robert H Lurie Cancer Center, Northwestern University, Chicago, IL, USA.
Sumita
S
Raha
Tatjana
T
Paunesku
Gayle
G
Woloschak
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D058726:Nanoconjugates / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy*; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D013347:Subcellular Fractions / Q000378:metabolism
D058726:Nanoconjugates; D010455:Peptides