Genetic predisposition to papillary thyroid cancer.
Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we discuss the results of linkage analysis and the most recent results of genome wide association studies (GWAS) with high resolution SNP (single nucleotide polymorphism) arrays.
Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska Curie Memorial Cancer Centre and Institite of Oncology, Gliwice Branch. dkula@io.gliwice.pl
Dorota
D
Kula
Michał
M
Kalemba
Beata
B
Jurecka-Lubieniecka
Zbigniew
Z
Puch
Małgorzata
M
Kowalska
Tomasz
T
Tyszkiewicz
Monika
M
Kowal
Daria
D
Handkiewicz-Junak
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D002277:Carcinoma; D002291:Carcinoma, Papillary; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics