Tandem facial amphiphiles for membrane protein stabilization.
We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.
Pil Seok
PS
Chae
Kamil
K
Gotfryd
Jennifer
J
Pacyna
Larry J W
LJ
Miercke
Søren G F
SG
Rasmussen
Rebecca A
RA
Robbins
Rohini R
RR
Rana
Claus J
CJ
Loland
Brian
B
Kobilka
Robert
R
Stroud
Bernadette
B
Byrne
Ulrik
U
Gether
Samuel H
SH
Gellman
D001436:Bacteriorhodopsins / Q000737:chemistry; D003840:Deoxycholic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D008320:Maltose / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry*; D008823:Micelles; D055550:Protein Stability / Q000187:drug effects; D016354:Rhodobacter capsulatus; D013997:Time Factors; D014867:Water / Q000737:chemistry
D008565:Membrane Proteins; D008823:Micelles; D003840:Deoxycholic Acid; D014867:Water; D001436:Bacteriorhodopsins; D008320:Maltose