Trimodal therapy for inflammatory breast cancer: a surgeon's perspective.
Inflammatory breast cancer (IBC) is a rare and most aggressive form of breast cancer. The onset and progression of disease are rapid; diagnosis must be made expediently to initiate treatment quickly. In this review, the clinical presentation, trimodal therapy, surgical principles and a brief summary of the Louisiana State University at Shreveport experience with IBC are presented. With this aggressive approach, 5-year survival of better than 40-50% can be expected. This represents a substantive improvement in clinical outcome for IBC patients compared with 30 years ago.
Department of Surgery, Radiology, Pathology and Medicine, Louisiana State University Health Sciences Center in Shreveport, and Feist-Weiller Cancer Center, Shreveport, La 71130, USA. bli@lsuhsc.edu
Benjamin D
BD
Li
Mark A
MA
Sicard
Fred
F
Ampil
Fleurette
F
Abreo
David
D
Lilien
Quyen D
QD
Chu
Gary V
GV
Burton
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis*; D017024:Chemotherapy, Adjuvant; D000075202:Contraindications; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008327:Mammography; D015411:Mastectomy, Modified Radical; D008413:Mastitis / Q000175:diagnosis; D020360:Neoadjuvant Therapy / Q000379:methods; D010166:Palliative Care / Q000379:methods; D049268:Positron-Emission Tomography; D018714:Radiotherapy, Adjuvant; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D021701:Sentinel Lymph Node Biopsy; D016217:Ultrasonography, Mammary
D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human