Research progress in Shigella in the postgenomic era.
Gram-negative, facultative intracellular anaerobes of the genus Shigella, the principal etiologic agents of shigellosis, continue to pose a threat to public health. Shigellosis causes 1.1 million deaths with over 164 million annual cases. The Shigella spp. can be divided into four serogroups: Shigella dysenteriae, Shigella flexneri, Shigella boydii and Shigella sonnei. The completion of seven Shigella genome sequences of representative strains from each of the Shigella species has introduced an era of whole-genome study. This paper reviews contemporary understanding of genomics, transcriptomics, proteomics and the structural biology of Shigella.
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100176, China.
JunPing
J
Peng
Jian
J
Yang
Qi
Q
Jin
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D055028:Comparative Genomic Hybridization; D004405:Dysentery, Bacillary / Q000382:microbiology / Q000401:mortality; D020869:Gene Expression Profiling; D016680:Genome, Bacterial; D006801:Humans; D040901:Proteomics; D012760:Shigella / Q000145:classification / Q000235:genetics
D001426:Bacterial Proteins