Effect of autoimmune thyroid disease in older euthyroid infertile woman during the first 35 days of an IVF cycle.
In this case-control study of euthyroid first-cycle IVF patients ≥ 38 years old with singleton baby, miscarriage, biochemical pregnancy, and no pregnancy outcomes from 2005-2008, we assayed frozen serum for autoimmune thyroid disease (AITD) and thyroid function at cycle start, trigger, and 4 and 5 weeks' gestation. AITD prevalence in older infertile women was similar across clinical outcomes, and although AITD was associated with a higher baseline TSH, TSH remained within acceptable ranges, suggesting that T(4) supplementation may not affect maternal outcomes in older euthyroid AITD patients through 5 weeks gestation.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York University Fertility Center, New York, New York, USA.
Andrea
A
Reh
Sonal
S
Chaudhry
Felicia
F
Mendelsohn
Shelly
S
Im
Linda
L
Rolnitzky
Alana
A
Amarosa
Mortimer
M
Levitz
Suman
S
Srinivasa
Lewis
L
Krey
Alan S
AS
Berkeley
James A
JA
Grifo
Ann
A
Danoff
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D015995:Prevalence; D013961:Thyroid Gland / Q000502:physiology*; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology*