A glimpse at regulation of nitrogen homeostasis.
NrpR is a 2-oxoglutarate (2OG)-sensing transcription factor found in the archaeal phylum euryarchaetoa. When 2OG concentrations are low, NrpR transcriptionally represses expression of the nitrogen acquisition genes. Structural studies by Wisedchaisri et al. (2010) have identified the cleft region, where 2OG binds to NrpR. Their study has highlighted conservation of 2OG-binding residues among other 2OG-responsive proteins.
School of Agriculture, Food, and Wine, The University of Adelaide, Glen Osmond, SA 5064, Australia. brent.kaiser@adelaide.edu.au
Brent N
BN
Kaiser
Maria
M
Hrmova