[Modest risk of phosphate nephropathy by bowel cleansing].
Acute phosphate nephropathy is a rare, but serious adverse event associated with the use of sodium phosphate for bowel cleansing. It may lead to permanent renal impairment and a need for dialysis. The aetiology is hyperphosphataemia caused by intestinal absorption of the cleanser. Risk factors include: advanced age, existing kidney disease, decreased intravascular volume, and medications affecting renal perfusion or function such as diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and possibly nonsteroidal anti-inflammatory drugs.
Endoskopiafsnit 332, Gastroenheden, Hvidovre Hospital, 2650 Hvidovre, Denmark. pns@dadlnet.dk
Palle Nordblad
PN
Schmidt
Jakob W
JW
Hendel
D000284:Administration, Oral; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects*; D003113:Colonoscopy; D004733:Enema / Q000379:methods*; D006801:Humans; D054559:Hyperphosphatemia / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D009397:Nephrocalcinosis / Q000139:chemically induced; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects; D017410:Practice Guidelines as Topic; D051437:Renal Insufficiency / Q000139:chemically induced; D012307:Risk Factors; D007507:Therapeutic Irrigation
D002400:Cathartics; D010710:Phosphates; D011092:Polyethylene Glycols; C018279:sodium phosphate