Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.
Chronic kidney disease (CKD) is a common cause of end-stage renal disease. Antihypertensive agents are used clinically to inhibit the progression of CKD, but cannot prevent eventual renal failure. This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy. After development of renal insufficiency, the rats were treated with Tanshinone IIA (10 mg/kg) for 8 weeks. Serum creatinine, angiotensin II (Ang II), transforming growth factor β1 (TGF-β1) and collagen IV levels were significantly reduced in Tanshinone IIA treated rats compared with a control group. In addition, Tanshinone IIA suppressed increases in urinary protein excretion in CKD rats. These findings suggest that chronic oral administration of Tanshinone IIA can improve renal dysfunction associated with CKD.
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea.
Young-Min
YM
Ahn
Su Kang
SK
Kim
Sang-Hun
SH
Lee
Se-Young
SY
Ahn
Sung Wook
SW
Kang
Joo-Ho
JH
Chung
Sung-Do
SD
Kim
Byung-Cheol
BC
Lee
D045784:Abietanes; D000284:Administration, Oral; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D024141:Collagen Type IV / Q000097:blood; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008297:Male; D010616:Phenanthrenes / Q000494:pharmacology*; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D053773:Transforming Growth Factor beta1 / Q000097:blood
D045784:Abietanes; D024141:Collagen Type IV; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D053773:Transforming Growth Factor beta1; C021751:tanshinone; D000804:Angiotensin II; D003404:Creatinine