Growth factors in induction of epithelial-mesenchymal transition and metastasis.
Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be critical in manipulating this process to develop novel anti-metastasis therapies.
Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Melbourne, VIC, Australia.
Nur Akmarina B M
NA
Said
Elizabeth D
ED
Williams
D000818:Animals; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*
D036341:Intercellular Signaling Peptides and Proteins