Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology.
Sepsis is a leading cause of mortality in neutropenic cancer patients. Early initiation of effective causative therapy as well as intensive adjunctive therapy is mandatory to improve outcome. We give recommendations for the management of adults with neutropenia and sepsis. The guidelines are written for clinicians involved in care of cancer patients and focus on pathophysiology, diagnosis and treatment of sepsis during neutropenia.
Department of Hematology and Oncology, Charité Campus Benjamin Franklin, Berlin. Electronic address: olaf.penack@charite.de.
O
O
Penack
Third Department of Internal Medicine, University Medical Centre Mannheim, University of Heidelberg, Heidelberg.
D
D
Buchheidt
Department of Internal Medicine IV, Oncology and Hematology, University Hospital of Martin-Luther-University, Halle (Saale).
M
M
Christopeit
Department of Haematology and Oncology, University of Bonn, Bonn.
M
M
von Lilienfeld-Toal
Second Department of Internal Medicine, Hospital Gütersloh, Gütersloh.
G
G
Massenkeil
Department of Hematology, Oncology and Palliative Care, Harlaching Hospital, Munich.
M
M
Hentrich
Department of Haematology and Oncology, Asklepios Hospital Altona, Hamburg.
H
H
Salwender
Department of Internal Medicine IV, Oncology and Hematology, University Hospital of Martin-Luther-University, Halle (Saale).
H-H
HH
Wolf
Third Department of Internal Medicine, Ludwig-Maximilians University, Munich, Germany.
H
H
Ostermann
D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000209:etiology / Q000628:therapy; D019468:Disease Management; D044882:Glucose Metabolism Disorders / Q000209:etiology / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D051437:Renal Insufficiency / Q000209:etiology / Q000628:therapy; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
D000890:Anti-Infective Agents; D000925:Anticoagulants; D000970:Antineoplastic Agents