Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.
The 2'-5'-oligoadenylate synthetase (2'-5'-OAS) family members are interferon-induced antiviral proteins. Twenty-three single nucleotide polymorphisms located within the OAS1, OAS2, OAS3, and OASL genes were analyzed in 142 patients with Russian tick-borne encephalitis. Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group. The data suggest a possible association between these 5 OAS single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
Institute of Cytology and Genetics, Siberian Branch of Russian Acadamy of Sciences, Siberian Branch of Russian Academy of Medical Sciences.
Andrey V
AV
Barkhash
Andrey A
AA
Perelygin
Vladimir N
VN
Babenko
Natalia G
NG
Myasnikova
Pavel I
PI
Pilipenko
Aida G
AG
Romaschenko
Mikhail I
MI
Voevoda
Margo A
MA
Brinton
D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D012426:Russia
D015088:2',5'-Oligoadenylate Synthetase