Total synthesis of (±) maoecrystal V.
A concise first total synthesis of (±) maoecrystal V (1) is reported. The synthesis features a Wessely oxidative dearomatization of a phenol, an intramolecular Diels-Alder reaction, and a Rh-catalyzed O-H bond insertion as key steps.
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
Jianxian
J
Gong
Guang
G
Lin
Wenbo
W
Sun
Chuang-Chuang
CC
Li
Zhen
Z
Yang
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D001688:Biological Products; D004224:Diterpenes; C545599:maoecrystal V