[The risk factors for aspirin induced peptic ulcer].
Older age, prior GI events, chronic renal failure, use of other injurious medicine such as NSAIDs, antithrombotic medicine, especially thienopyridine, and corticosteroids seem to be factors associated with an increased risk for upper GI ulcer and bleeding among the patients taking low dose aspirin. We have previously shown that hypoacidity related with corpus atrophy as well as taking PPI and co-treatment of angiotensin type 1 receptor blocker seem to reduce peptic ulcer among aspirin users. In addition, the polymorphisms of interleukin-1beta -511/-31 and angiotensinogen -20CC were significantly associated with ulcer or ulcer bleeding. The further prospective studies are needed to identify specific risk factors for upper GI ulcer and its complications in Japanese patients.
Division of Gastroenterology, Kawasaki Medical School.
Akiko
A
Shiotani
Tomoari
T
Kamada
Noriaki
N
Manabe
Hiroshi
H
Imamura
Ken
K
Haruma
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced*; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin