Clinical analysis of high serum IgE in autoimmune pancreatitis.
OBJECTIVE
To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP).


METHODS
Forty-two AIP patients, whose IgE was measured before steroid treatment, were analyzed. To evaluate the relationship between IgE levels and the disease activity of AIP, we examined (1) Frequency of high IgE (> 170 IU/mL) and concomitant allergic diseases requiring treatment; (2) Correlations between IgG, IgG4, and IgE; (3) Relationship between the presence of extrapancreatic lesions and IgE; (4) Relationship between clinical relapse and IgE in patients treated with steroids, and (5) Transition of IgE before and after steroid treatment.


RESULTS
IgE was elevated in 36/42 (86%) patients. Concomitant allergic disease was observed in seven patients (allergic rhinitis in three, bronchial asthma in three, and urticaria in one). There were no significant correlations between IgG, IgG4, and IgE (r = -0.168 for IgG, and r = -0.188 for IgG4). There was no significant difference in IgE in the patients with and without extrapancreatic lesions (526 ± 531 IU/mL vs 819 ± 768 IU/mL, P = 0.163), with and without clinical relapse (457 ± 346 IU/mL vs 784 ± 786 IU/mL, P = 0.374). There was no significant difference in IgE between before and after steroid treatment (723 ± 744 IU/mL vs 673 ± 660 IU/mL, P = 0.633).


CONCLUSIONS
Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage.
Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. khirano-tky@umin.ac.jp
Kenji
K
Hirano
Minoru
M
Tada
Hiroyuki
H
Isayama
Kazumichi
K
Kawakubo
Hiroshi
H
Yagioka
Takashi
T
Sasaki
Hirofumi
H
Kogure
Yousuke
Y
Nakai
Naoki
N
Sasahira
Takeshi
T
Tsujino
Nobuo
N
Toda
Kazuhiko
K
Koike
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D012008:Recurrence; D013256:Steroids / Q000627:therapeutic use
D007074:Immunoglobulin G; D013256:Steroids; D007073:Immunoglobulin E