Clinical aspects of gastric cancer and Helicobacter pylori--screening, prevention, and treatment.
Gastric cancer still represents a global health care burden, and in the absence of strategies implemented for early detection, the disease continues to have a dismal prognosis. Patients presenting with clinical manifestations of gastric cancer have limited options for cure. Thus, early detection and prevention play a key role in the fight against gastric cancer. Serologic-based test methods have the potential to detect a subset of patients at high risk of gastric cancer that require a close clinical and endoscopic follow-up. More data have been produced to support Helicobacter pylori eradication as an efficient strategy to prevent gastric cancer. Treatment options for patients with an advanced disease are still limited, but the introduction of new agents opens a more optimistic perspective for the future.
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany.
Michael
M
Selgrad
Jan
J
Bornschein
Theodore
T
Rokkas
Peter
P
Malfertheiner
D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000382:microbiology* / Q000517:prevention & control