A lifespan analysis of intraneocortical connections and gene expression in the mouse I.
A hallmark of mammalian evolution is the structural and functional complexity of the cerebral cortex. Within the cerebral cortex, the neocortex, or isocortex, is a 6-layered complexly organized structure that is comprised of multiple interconnected sensory and motor areas. These areas and their precise patterns of connections arise during development, through a process termed arealization. Intrinsic, activity-independent and extrinsic, activity-dependent mechanisms are involved in the development of neocortical areas and their connections. The intrinsic molecular mechanisms involved in the establishment of this sophisticated network are not fully understood. In this report (I) and the companion report (II), we present the first lifespan analysis of ipsilateral intraneocortical connections (INCs) among multiple sensory and motor regions, from the embryonic period to adulthood in the mouse. Additionally, we characterize the neocortical expression patterns of several developmentally regulated genes that are of central importance to studies investigating the molecular control of arealization from embryonic day 13.5 to postnatal day (P) 3 (I) and P6 to 50 (II). In this analysis, we utilize novel methods to correlate the boundaries of gene expression with INCs and developing areal boundaries, in order to better understand the nature of gene-areal relationships during development.
Department of Psychology and Interdepartmental Neuroscience Program, University of California-Riverside, 900 University Avenue, Riverside, CA 92521, USA.
Catherine A
CA
Dye
Hani
H
El Shawa
Kelly J
KJ
Huffman
D000367:Age Factors; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001931:Brain Mapping; D051836:COUP Transcription Factors / Q000235:genetics / Q000378:metabolism; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D004622:Embryo, Mammalian; D036386:Ephrin-A5 / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D051797:Inhibitor of Differentiation Protein 2 / Q000235:genetics / Q000378:metabolism; D060850:LIM-Homeodomain Proteins; D051379:Mice; D009434:Neural Pathways / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D057095:Nuclear Receptor Subfamily 1, Group F, Member 2 / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy; D011726:Pyridinium Compounds / Q000378:metabolism; D036141:Receptor, EphA7 / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D000596:Amino Acids; D051836:COUP Transcription Factors; D015820:Cadherins; C504541:Cdh8 protein, mouse; D036386:Ephrin-A5; D018398:Homeodomain Proteins; C497452:Idb2 protein, mouse; D051797:Inhibitor of Differentiation Protein 2; D060850:LIM-Homeodomain Proteins; C489784:Lhx2 protein, mouse; D057095:Nuclear Receptor Subfamily 1, Group F, Member 2; D011726:Pyridinium Compounds; C539741:Rorb protein, mouse; D014157:Transcription Factors; C098463:dolaisoleucine; C076868:4-(4-dihexadecylaminostyryl)-N-methylpyridium; D036141:Receptor, EphA7