Polymyxin-resistant clinical isolates of Escherichia coli.
A surveillance study to identify patients from the community with Escherichia coli resistant to broad-spectrum cephalosporins discovered two isolates that were also resistant to polymyxin B and colistin. One isolate from a patient in the community and a second from a patient who received multiple courses of polymyxin B also possessed a CTX-M-15 enzyme. Resistance to cationic peptides in E. coli is unusual, and testing for susceptibility to these agents should be performed.
Infectious Disease Section, New York Hospital Queens, Flushing, NY 11355, USA. cmurban@nyp.org
Carl
C
Urban
Hemavarna
H
Tiruvury
Noriel
N
Mariano
Rita
R
Colon-Urban
James J
JJ
Rahal
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003091:Colistin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011112:Polymyxin B / Q000494:pharmacology; D011113:Polymyxins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011113:Polymyxins; D011112:Polymyxin B; D003091:Colistin