Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles.
To determine the impact of maternal metabolic state on oocyte development in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), we retrospectively analyzed a cohort of women with PCOS undergoing IVF/ICSI from 2008-2009 in a university-based fertility center. We determined that women with PCOS and obesity have smaller oocytes than control subjects, and that when further subdivided by body mass index, both PCOS and obesity independently influence oocyte size.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Kerri L
KL
Marquard
Sahar M
SM
Stephens
Emily S
ES
Jungheim
Valerie S
VS
Ratts
Randall R
RR
Odem
Susan
S
Lanzendorf
Kelle H
KH
Moley
D000328:Adult; D048429:Cell Size; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D009865:Oocytes / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D055815:Young Adult