The clinical significance of HPV screening in premalignant cervical lesions.
OBJECTIVE
We evaluated the clinical significance of human papilloma virus (HPV) screening in premalignant cervical lesions.


METHODS
This prospective study was performed at Dicle University, School of Medicine, Department of Obstetrics and Gynecology, from January 2009 to June 2009. A total of 60 cases were evaluated. Thirty cases had premalignant cervical lesions. The prevalence of HPV was analyzed by polymerase chain reaction and types determined by Hybrid Capture II. The cases that had premalignant cervical lesions were evaluated with colposcopy. Statistical analyses were carried out by using the statistical packages for SPSS version 12.0 for Windows (Chicago, IL, USA).


RESULTS
Of all the cases, those with premalignant cervical lesions had higher prevalence of HPV DNA. The cases that had high oncogenic HPV type had more abnormal colposcopic findings.


CONCLUSIONS
Premalignant cervical lesions should be evaluated by cervical cytology, colposcopy, HPV DNA screening and cervical tissue sampling. In this way, development of cervical cancer can be prevented.
Department of Obstetrics and Gynecology, Dicle University, Faculty of Medicine, Diyarbakir, Turkey.
U
U
Kuyumcuoglu
S
S
Hocaoglu
A I
AI
Guzel
Y
Y
Celik
D000328:Adult; D052685:Alphapapillomavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016022:Case-Control Studies; D003127:Colposcopy; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D011230:Precancerous Conditions / Q000821:virology*; D015995:Prevalence; D011446:Prospective Studies; D014421:Turkey / Q000453:epidemiology; D002578:Uterine Cervical Dysplasia / Q000821:virology*
D004279:DNA, Viral