Synthesis of monoacylated derivatives of 1,2- cyclohexanediamine. Evaluation of their catalytic activity in the preparation of Wieland-Miescher ketone.
Ureas, carbamoyl derivatives, amides, and sulfonamides can be easily prepared from the strained (R,R)-cylohexanediamine urea (1) in high yield, leaving a free amino group that shows good catalytic activity in intramolecular aldol condensations. The preparation of Wieland-Miescher ketone has been studied with these catalysts.
Organic Chemistry Department, Plaza de los Caídos 1-5, Universidad de Salamanca, Salamanca 37008, Spain.
Ángel L
ÁL
Fuentes de Arriba
David G
DG
Seisdedos
Luis
L
Simón
Victoria
V
Alcázar
César
C
Raposo
Joaquín R
JR
Morán