[High seroprevalence of cytomegalovirus, herpes simplex type 1 virus and Epstein Barr virus infection among human immunodeficiency virus-infected adults].
BACKGROUND
Cytomegalovirus (CMV), herpes simplex type I (HSV-1) and Epstein Barr virus (EBV) are latent persistent infections. Their reactivation may cause illnesses and death in human immunodeficiency virus-infected (HIV) people. World wide seroprevalence of these viruses is over 50%. In Chile, information is not available.


OBJECTIVE
To determine the seroprevalence of CMV HSV-1 and EBV in Chilean HIV-infected adults.


METHODS
A total of 400 HIV-infected adults aged 17 to 67 years (340 males) were studied during 2005 and 2006 CMV HSV-1 and EBV serum antibodies were measured by enzyme-linked immunoabsorbent assay.


RESULTS
The mean lapse from the diagnosis of HIV and serum testing was 67 months and 69.5% patients received antiretroviral therapy. Sixty seven percent of the sample were men who had sex with men (MSM). The seroprevalence for CM, HSV-1 and EBV were 98.5, 92.2 and 99.7%, respectively. No patient had negative antibodies for all three viruses. Male patients that were negative for HSV-1 had a lower frequency of MSM than the rest of males (26% vs. 62%, p < 0.01).


CONCLUSIONS
There is a high prevalence of positive antibodies against CMV HSV-1 and EBV in Chilean adults infected with HIV Specific diagnostic tests and antiviral therapy should be available for these patients.
Programa de Virología, ICBM, Facultad de Medicina, Universidad de Chile. vluchsin@med.uchile.cl
Vivian
V
Luchsinger
Amaranta
A
Luzoro
María José
MJ
Martínez
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D002677:Chile / Q000453:epidemiology; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006561:Herpes Simplex / Q000453:epidemiology* / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D055815:Young Adult
D000914:Antibodies, Viral