Antifungal cyclic peptides from Psammosilene tunicoides.
Three new cyclic peptides, tunicyclins B-D, and a known cyclic peptide, psammosilenin B, were isolated from the root of Psammosilene tunicoides. The structures of new cyclic peptides were elucidated by extensive NMR and MS analysis. Tunicyclin B contains an unusual α,β-dehydrotryptophan (Δ(Z)-Trp) residue, previously reported from marine sponges and bacteria. Tunicyclin D showed a broad spectrum of antifungal activity against Candida albicans (SC5314), Candida albicans (Y0109), Candida tropicalis, Candida parapsilosis, and Cryptococcus neoformans (BLS108) with MIC(80) values of 4.0, 16.0, 0.25, 1.0, and 1.0 μg mL(-1), respectively.
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Junmian
J
Tian
Yunheng
Y
Shen
Xianwen
X
Yang
Shuang
S
Liang
Lei
L
Shan
Huiliang
H
Li
Runhui
R
Liu
Weidong
W
Zhang
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D029748:Caryophyllaceae / Q000737:chemistry*; D003455:Cryptococcus neoformans / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D010456:Peptides, Cyclic; C555178:tunicyclin B; C555180:tunicyclin C; C555179:tunicyclin D