In(III)-catalyzed tandem reaction of chromone-derived Morita-Baylis-Hillman alcohols with amines.
The reaction of chromone-derived cyclic Morita-Baylis-Hillman alcohols with amines catalyzed by In(OTf)(3) in a one pot process was developed for the convenient and efficient synthesis of 2-substituted-3-aminomethylenechromans. The tandem allylic amination/chromen ring-opening/Michael cyclization reactions were involved in this protocol.
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chen
C
Wu
Yuliang
Y
Liu
Hao
H
Zeng
Li
L
Liu
Dong
D
Wang
Yongjun
Y
Chen
D000438:Alcohols / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002867:Chromones / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D000438:Alcohols; D000588:Amines; D002867:Chromones; D007204:Indium