Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication of dermatomyositis.
Dermatomyositis (DM) is occasionally complicated by interstitial lung disease. Acute/subacute interstitial pneumonia (A/SIP) with DM is intractable and life threatening. Clinically amyopathic dermatomyositis (C-ADM) is also reported to be complicated with A/SIP, especially in those patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody. In the present cases, we indicate that serum ferritin level correlated with activity of A/SIP with DM. Two patients, a 65-year-old woman and a 30-year-old woman, were diagnosed with anti-MDA5 antibody-associated A/SIP with DM. Serum ferritin was high, 1600 and 770 mg/dl, respectively, on admission. Immunosuppressive therapy ameliorated A/SIP in both cases. Similarly, serum ferritin was also decreasing. However, A/SIP was recurrent and progressive, and serum ferritin was also increasing again in one case. In conclusion, serum ferritin correlates with disease activity of anti-MDA5 antibody-associated A/SIP with DM. Intensity of treatment may be decided according to serum ferritin level.
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-Ku, Tokyo, 162-0054, Japan.
Takahisa
T
Gono
Yasushi
Y
Kawaguchi
Eri
E
Ozeki
Yuko
Y
Ota
Takashi
T
Satoh
Masataka
M
Kuwana
Masako
M
Hara
Hisashi
H
Yamanaka
D000208:Acute Disease; D000328:Adult; D000368:Aged; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000276:immunology*; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D016903:Drug Monitoring; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000072640:Interferon-Induced Helicase, IFIH1; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D007166:Immunosuppressive Agents; D005293:Ferritins; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1