A highly sensitive microRNA biosensor based on ruthenium oxide nanoparticle-initiated polymerization of aniline.
Well-defined voltammetric current peaks of polyaniline were observed at biosensors hybridized with ruthenium oxide nanoparticle-tagged microRNAs and incubated in a mixture of aniline/H(2)O(2), which can be used for direct microRNA expression profiling with excellent sensitivity.
Institute of Bioengineering and Nanotechnology, the Nanos, 31 Biopolis Way, Singapore 138669.
Yanfen
Y
Peng
Guangshun
G
Yi
Zhiqiang
Z
Gao
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015374:Biosensing Techniques; D035683:MicroRNAs; D053758:Nanoparticles / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D017975:Ruthenium Compounds
D000814:Aniline Compounds; D035683:MicroRNAs; D010087:Oxides; D017975:Ruthenium Compounds; C416807:polyaniline; D012428:Ruthenium; C027646:ruthenium tetraoxide; C023650:aniline