Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring.
Bisphenol A (BPA) is an estrogenic agonist compound that induces changes in diverse reproductive parameters in rats. The aim of the present study was to determine the effects of BPA given in drinking water containing 10mg/L (approximate dose 1.2mg/kg BW/day), administered chronically to rats during pregnancy and lactation, on reproductive tract parameters of the offspring. 79.2% of the female offspring from BPA-treated mothers presented irregular estrous cycles. As compared to the control group, a significant increase in the thickness of the uterine epithelia and stroma was observed in the BPA group. Additionally, 60% of the female offspring from BPA mothers did not undergo abundant uterine epithelial apoptosis during the estrus phase of the cycle while control animals did. In addition, a down regulation of ERα expression was observed in epithelial cells on estrus day. The results indicate that BPA, when administered chronically in water beverages to dams, modifies the reproductive cycle of the offspring during young adulthood.
Universidad Nacional Autónoma de México, Facultad de Química, Edificio F. Lab. Biología de la Reproducción, México, D.F., Mexico. adrimed@yahoo.com
C Adriana
CA
Mendoza-Rodríguez
Montserrat
M
García-Guzmán
Noemí
N
Baranda-Avila
Sumiko
S
Morimoto
Martine
M
Perrot-Applanat
Marco
M
Cerbón
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001559:Benzhydryl Compounds; D004848:Epithelium / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects; D047628:Estrogen Receptor alpha / Q000032:analysis; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D007774:Lactation; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D014599:Uterus / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects; D014867:Water; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D047628:Estrogen Receptor alpha; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D014867:Water; C006780:bisphenol A; D000098826:Bisphenol A Compounds