Relevance of disease- and organ-specific endothelial cells for in vitro research.
The endothelium is a dynamic, heterogeneous, disseminated organ that possesses vital secretory, synthetic, metabolic and immunological functions. Endothelial dysfunction has been implicated as a key factor in the development of organ-specific vascular diseases. This minireview gives a brief overview on EC (endothelial cell) biomarkers in arterial and venous endothelium and critically discusses the different sources of ECs that are most frequently applied in in vitro assays and research. The relevance of organ- and disease-specific endothelial cell cultures for studying cellular responses as a basis for improving therapeutic interventions is highlighted with particular emphasis on endothelial dysfunction in transplant-associated coronary artery disease, in atherosclerotic lesions and in response to diabetes mellitus.
Department of Cardiothoracic Surgery, University Hospital Regensburg, 93042 Regensburg, Germany. karla.lehle@klinik.uni-regensburg.de
Karla
K
Lehle
Rainer H
RH
Straub
Henning
H
Morawietz
Leoni A
LA
Kunz-Schughart
D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002478:Cells, Cultured; D004194:Disease; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology* / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity; D012107:Research Design
D015415:Biomarkers