Neurofibromatosis type 1 associated with bilateral central giant cell granuloma of the mandible.
Neurofibromatosis type 1, or von Recklinghausen disease, is one of the most common hereditary neurocutaneous disorders in humans. Clinically, Neurofibromatosis type 1 is characterized by café-au-lait spots, freckling, skin neurofibroma, plexiform neurofibroma, bony defects, Lisch nodules and tumors of the central nervous system. Central giant cell granuloma is a benign central lesion of bone, primarily involving the jaws, of variably aggressive nature characterized by aggregates of multinucleated giant cells in a background of cellular vascular fibrous connective tissue and spindle-shaped mononuclear stromal cells. The association between neurofibromatosis and central giant cell granuloma has been reported in the literature. A case of mandibular bilateral central giant cell granuloma in a patient with Neurofibromatosis type 1 was conservatively but successfully treated by adequate surgical curettage of mandibular bone lesions.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Pontifícia Universidade Católica de Minas Gerais, Av. Dom José Gaspar, 500 Prédio 45, Coração Eucarístico, Belo Horizonte, MG, Brazil. brunochrcanovic@hotmail.com
Bruno Ramos
BR
Chrcanovic
Ricardo Santiago
RS
Gomez
Belini
B
Freire-Maia
D000293:Adolescent; D003475:Curettage; D003937:Diagnosis, Differential; D005260:Female; D006101:Granuloma, Giant Cell / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008336:Mandibular Diseases / Q000150:complications* / Q000473:pathology / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000150:complications*; D014057:Tomography, X-Ray Computed