Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines.
A facile, efficient, three-step protocol for the synthesis of the unknown quinolino[2,3-c]cinnoline 5 is introduced. In addition, a new approach for the preparation of the biologically active neocryptolepines 8 in good overall yields is described.
Department of Chemistry, American University of Beirut, Beirut, Lebanon. haddadin@aub.edu.lb
Makhluf J
MJ
Haddadin
Raghida M
RM
Bou Zerdan
Mark J
MJ
Kurth
James C
JC
Fettinger
D000470:Alkaloids / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*
D000470:Alkaloids; D006574:Heterocyclic Compounds, 2-Ring; D011804:Quinolines; C414982:neocryptolepine; C037219:quinoline; C476282:cinnoline