Primary sellar neuroblastoma presenting with syndrome of inappropriate secretion of anti-diuretic hormone.
A 29-year-old Ethiopian man presented with marked bilateral visual loss, headache, hypopituitarism and significant hyponatraemia (115 mmol/L). A brain MRI scan demonstrated a large, lobulated, sellar and suprasellar mass, elevating the floor of the 3rd ventricle and compressing the optic chiasm. The patient underwent a transphenoidal resection of the mass followed by a craniotomy 10 days later. Histological examination demonstrated a Hyams' grade III neuroblastoma with ectopic expression of vasopressin. He underwent fractionated radiotherapy at a dose of 60 Gy in 30 fractions. Fourteen months after the onset, he is well with no neuroimaging evidence of tumour recurrence. His serum and urine sodium are completely normalised.
Department of Medicine, Faculty of Medicine, Charing Cross Campus, Imperial College, London, UK.
Bishan
B
Radotra
Vasileios
V
Apostolopoulos
Ann
A
Sandison
Emma C I
EC
Hatfield
Nigel
N
Mendoza
Jill
J
Moss
Amrish
A
Mehta
Mark
M
Glaser
Karim
K
Meeran
Federico
F
Roncaroli
D000328:Adult; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000503:physiopathology; D013577:Syndrome