Cysteine peptidases and their inhibitors in breast and genital cancer.
Cysteine proteinases and their inhibitors probably play the main role in carcinogenesis and metastasis. The metastasis process need external proteolytic activities that pass several barriers which are membranous structures of the connective tissue which includes, the basement membrane of blood vessels. Activities of the proteinases are regulated by endogenous inhibitors and activators. The imbalance between cysteine proteinases and cystatins seems to be associated with an increase in metastatic potential in some tumors. It has also been reported that proteinase inhibitors, specific antibodies for these enzymes and inhibition of the urokinase receptor may prevent cancer cell invasion. Some proteinase inhibitor could serve as agents for cancer treatment.
II Department of Surgery and Oncology, Wroclaw Medical University, Wroclaw, Poland. dranilpreeti@gmail.com
Anil Kumar
AK
Agrawal
Godwin Bwire
GB
Ekonjo
Elżbieta
E
Teterycz
Dorota
D
Zyoeko
Zygmunt
Z
Grzebieniak
Magdalena
M
Milan
Grzegorz
G
Marek
Maciej
M
Siewiński
D001943:Breast Neoplasms / Q000201:enzymology*; D003545:Cysteine / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D010450:Endopeptidases / Q000378:metabolism; D005260:Female; D005833:Genital Neoplasms, Female / Q000201:enzymology*; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism*
D015853:Cysteine Proteinase Inhibitors; D010450:Endopeptidases; D010447:Peptide Hydrolases; D003545:Cysteine