Decision-making cognition in neurodegenerative diseases.
A large proportion of human social neuroscience research has focused on the issue of decision-making. Impaired decision-making is a symptomatic feature of a number of neurodegenerative diseases, but the nature of these decision-making deficits depends on the particular disease. Thus, examining the qualitative differences in decision-making impairments associated with different neurodegenerative diseases could provide valuable information regarding the underlying neural basis of decision-making. Nevertheless, few comparative reports of decision-making across patient groups exist. In this Review, we examine the neuroanatomical substrates of decision-making in relation to the neuropathological changes that occur in Alzheimer disease, frontotemporal dementia, Parkinson disease and Huntington disease. We then examine the main findings from studies of decision-making in these neurodegenerative diseases. Finally, we suggest a number of recommendations that future studies could adopt to aid our understanding of decision-making cognition.
Institute of Cognitive Neurology (INECO), Favaloro University, Castex 3293 (1425), Buenos Aires, Argentina. egleichgerrcht@neurologiacognitiva.org
Ezequiel
E
Gleichgerrcht
Agustín
A
Ibáñez
María
M
Roca
Teresa
T
Torralva
Facundo
F
Manes
D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003657:Decision Making / Q000502:physiology*; D003704:Dementia / Q000175:diagnosis / Q000523:psychology*; D056344:Executive Function / Q000502:physiology; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D016743:Mental Competency / Q000523:psychology*; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000523:psychology