Structure and antibacterial activity of the silver(I) complex of 2-aminophenoxazine-3-one.
The crystal structure and antibacterial activity of the first metal complex of 2-aminophenoxazine-3-one is reported. We describe the silver(i) complex of this important biological molecule and show that the binding mode is through the phenoxazine ring nitrogen. A new synthetic route to 2-aminophenoxazine-3-one is also reported.
Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Komala
K
Pandurangan
Shane
S
Gallagher
Grace G
GG
Morgan
Helge
H
Müller-Bunz
Francesca
F
Paradisi
D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry*
D010078:Oxazines; C005512:3-aminophenoxazone; D012834:Silver