28-nor-oleanane-type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells.
Four new 28-nor-oleanane-type triterpene oligoglycosides, camellenodiol 3-O-β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-β-D-glucuronopyranoside (2), camellenodiol 3-O-4''-O-acetyl-β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-β-D-glucuronopyranoside (4), camellenodiol 3-O-(β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-6'-methoxy-β-D- glucuronopyranoside (5), and maragenin II 3-O-(β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-6'-methoxy-β-D-glucuronopyranoside (6), along with two known compounds, (1 and 3), were isolated from the stem bark of Camellia japonica. Their chemical structures were established mainly by 2D NMR techniques and mass spectrometry. The isolated compounds showed inhibitory effects on NO production in RAW264.7 macrophages.
College of Pharmacy, Catholic University of Daegu, Gyeongsan, Republic of Korea.
Nguyen Thi Phuong
NT
Thao
Tran Manh
TM
Hung
To Dao
TD
Cuong
Jin Cheol
JC
Kim
Eun Hee
EH
Kim
Seong Eun
SE
Jin
MinKyun
M
Na
Young Mi
YM
Lee
Young Ho
YH
Kim
Jae Sue
JS
Choi
Byung Sun
BS
Min
D028244:Camellia / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D009828:Oleanolic Acid / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D008070:Lipopolysaccharides; D012503:Saponins; D009569:Nitric Oxide; D009828:Oleanolic Acid