Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
BACKGROUND
Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.


METHODS
In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.


RESULTS
Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).


CONCLUSIONS
Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.
Bio-X Center and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Ti
T
Wang
Zhen
Z
Zeng
Tao
T
Li
Jie
J
Liu
Junyan
J
Li
You
Y
Li
Qian
Q
Zhao
Zhiyun
Z
Wei
Yang
Y
Wang
Baojie
B
Li
Guoyin
G
Feng
Lin
L
He
Yongyong
Y
Shi
D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D005006:Ethnicity; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C078341:MYT1 protein, human; D014157:Transcription Factors