New insights into the pelletization mechanism by extrusion/spheronization.
Pellet manufacturing by extrusion/spheronization is quite common in the pharmaceutical field because the obtained product is characterized by a high sphericity as well as a narrow particle size distribution. The established mechanisms only consider deformation of the initially fractured particles but do not account for mass transfer between the particles as a factor in achieving spherical particles. This study dealt with the visualization of mass transfer during spheronization. Therefore, two common pelletization aids, microcrystalline cellulose and kappa-carrageenan, were used alone as well as in combination with lactose as a filler. This study proves that mass transfer between particles must be considered in addition to plastic deformation in order to capture the spheronization mechanism. Moreover, it is evident that there are regional distinctions in the amount of mass transfer at the particle surface. Therefore, the commonly espoused pelletization mechanisms need to be extended to account for material transfer between pellet particles, which has not been considered before.
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany.
Martin
M
Koester
Markus
M
Thommes
D002351:Carrageenan / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D007785:Lactose / Q000737:chemistry*; D010316:Particle Size; D011208:Powders
D005079:Excipients; D011208:Powders; D002351:Carrageenan; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose