Biogenesis of nuclear bodies.
The nucleus is unique amongst cellular organelles in that it contains a myriad of discrete suborganelles. These nuclear bodies are morphologically and molecularly distinct entities, and they host specific nuclear processes. Although the mode of biogenesis appears to differ widely between individual nuclear bodies, several common design principles are emerging, particularly, the ability of nuclear bodies to form de novo, a role of RNA as a structural element and self-organization as a mode of formation. The controlled biogenesis of nuclear bodies is essential for faithful maintenance of nuclear architecture during the cell cycle and is an important part of cellular responses to intra- and extracellular events.
Department of Cell Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Ilinois 60064, USA. mirek.dundr@rosalindfranklin.edu
Miroslav
M
Dundr
Tom
T
Misteli
D053898:Biosynthetic Pathways / Q000502:physiology*; D022003:Cell Nucleus Structures / Q000145:classification / Q000378:metabolism* / Q000502:physiology*; D040582:Inheritance Patterns / Q000235:genetics*; D008938:Mitosis / Q000235:genetics / Q000502:physiology; D012313:RNA / Q000378:metabolism*
D012313:RNA