Two new phenolic amides from the seeds of Pharbitis nil.
Two new phenolic amides, pharnilatins A (1) and B (2), were isolated from the seeds of Pharbitis nil. These new compounds possess a p-coumaroyl unit with a structurally unique side chain, (2S,3S)-2,3-dihydroxyputrescine. The chemical structures and absolute stereochemistries of the new compounds were determined on the basis of spectroscopic analyses including 1D- and 2D-NMR experiments and chemical reactions. Compounds 1 and 2 exhibited cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cells. However, none of the compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated microglia cells.
Sungkyunkwan University, Suwon, Korea.
Ki Hyun
KH
Kim
Sang Un
SU
Choi
Mi Won
MW
Son
Kang Ro
KR
Lee
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D003373:Coumaric Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D049915:Ipomoea nil / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
C556519:9-(1',4'-diamino-2',3'-butanediol)-p-coumarate; D000577:Amides; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D003373:Coumaric Acids; D010636:Phenols; D010936:Plant Extracts