[Changes of oxidative stress in peripheral serum of patients with allergic rhinitis].
OBJECTIVE
To examine the changes of oxidative stress biomarkers in peripheral serum of patients with allergic rhinitis (AR), so as to investigate the role of oxidative stress in pathogenesis of AR.


METHODS
The levels of serum nitric oxide (NO), malondialdehyde (MDA), as well as the activities of serum nitric oxide synthase (NOS), antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in 48 AR patients and 23 healthy controls. Statistical analysis was performed using a SPSS 13.0 software.


RESULTS
The level of serum NO in AR group [(97.92 ± 73.42) µmol/L] was higher than that in healthy control group [(64.04 ± 29.54) µmol/L], the difference was significant (t = -0.281, P < 0.05). The ratio of inducible NOS (iNOS) to total NOS (TNOS) in AR group (0.51 ± 0.11) was higher than that in healthy control group(0.45 ± 0.15), the difference was significant (t = -2.061, P < 0.05). The activity of serum GSH-Px in AR group [(258.24 ± 45.25) U/(ml·min)] was higher than that in healthy control group (215.11 ± 47.62) U/(ml·min)], the difference was significant (t = -2.235, P < 0.05). Although activity of SOD, concentration of MDA in AR group had a tendency to increase and decrease, respectively, no significant statistical difference was found as compared to the control group (P > 0.05).


CONCLUSIONS
Oxidative stress is involved in the pathophysiology of AR, however, iNOS-NO pathway may play a more important role in AR pathogenesis.
Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology, Head and Neck Surgery (Capital Medical University), Ministry of Education, Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Affilitiated to Capital Medical University, Beijing 100005, China.
Jian
J
Jiao
Wei
W
Zhang
Na
N
Meng
Hong
H
Wang
Luo
L
Zhang
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood; D018384:Oxidative Stress; D012221:Rhinitis, Allergic, Perennial / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase