Fulminant type 1 diabetes in China: a case report and review of the literature.
Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes, defined as diabetes with an extremely rapid process of β-cell destruction and progression to hyperglycemia and ketoacidosis. In this report, we present a case of fulminant type 1 diabetes in a 45-year-old Chinese woman, along with a review of the literature. The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms. Findings on admission included a high blood glucose level and ketoacidosis, but normal HbA1c level. The C-peptide stimulation test showed severe impairment of insulin secretion. Autoantibodies to glutamic acid decarboxylase (GAD) were negative. These results are compatible with the diagnosis of fulminant type 1 diabetes. Human leukocyte antigen-DR7 (HLA-DR7) was available in this case. It is concluded that this rapidly progressing type of diabetes exists, and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.
Department of Endocrinology and Metabolism, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yun-fei
YF
Feng
Mei-fen
MF
Yao
Qi
Q
Li
Yan
Y
Sun
Cheng-jiang
CJ
Li
Jian-guo
JG
Shen
D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000145:classification* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged