Relationship between metabolic disorders and relative risk values of brain infarction estimated by protein-conjugated acrolein, IL-6 and CRP together with age.
BACKGROUND
We have recently found that the median relative risk value (RRV) (0-1) of brain infarction estimated by protein-conjugated acrolein (PC-Acro), IL-6 and CRP together with age was in the order silent brain infarction (SBI) (0.80)>carotid atherosclerosis (CA) (0.76)>white matter hyperintensity (WMH) (0.46)>control (0.14). We clarified how metabolic disorders [hypertension (HT), hyperlipidemia (HL) and hyperglycemia (HG)] are correlated with RRV.


METHODS
The levels of PC-Acro, IL-6 and CRP in plasma were measured by ELISA. SBI and WMH were evaluated by MRI, and CA was evaluated by duplex carotid ultrasonography.


RESULTS
The median RRV of metabolic disorders was in the order HT+HG (0.84)>HT+HL (0.73)>HT (0.65)≈HG (0.65)>HL (0.61)>HL+HG (0.48)>no metabolic disorder (0.24)>normal (0.11). Correlation with SBI was in the order HT+HG (52%)>HT+HL (42%)>HT (40%)>HG (34%)≈HL(33%)>HL+HG (14%)≈no metabolic disorder (14%).


CONCLUSIONS
The results indicate that HT is the most strongly associated factor with SBI among metabolic disorders and that the seriousness of metabolic disorder estimated by RRV was well correlated with SBI.
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Madoka
M
Yoshida
Mutsumi
M
Mizoi
Ryotaro
R
Saiki
Eiichi
E
Kobayashi
Naokatsu
N
Saeki
Kenji
K
Wakui
Tadafumi
T
Kusaka
Hirotaka
H
Takizawa
Koichi
K
Kashiwado
Norikazu
N
Suzuki
Kazumasa
K
Fukuda
Takao
T
Nakamura
Sakae
S
Watanabe
Kei
K
Tada
Hideyuki
H
Tomitori
Keiko
K
Kashiwagi
Kazuei
K
Igarashi
D000171:Acrolein / Q000378:metabolism*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000150:complications*; D002097:C-Reactive Protein / Q000378:metabolism*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014463:Ultrasonography
D015850:Interleukin-6; D000171:Acrolein; D002097:C-Reactive Protein