Behçet's disease (Adamantiades-Behçet's disease).
Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.
Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan. f.kaneko@mt.strins.or.jp
Fumio
F
Kaneko
Ari
A
Togashi
Sanae
S
Saito
Hideo
H
Sakuma
Noritaka
N
Oyama
Koichiro
K
Nakamura
Kenji
K
Yokota
Keiji
K
Oguma
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001528:Behcet Syndrome / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018834:Chaperonin 60 / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology; D059949:HLA-B51 Antigen; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology*; D013281:Stomatitis, Aphthous
D000942:Antigens, Bacterial; C114325:BES-1 protein, Streptococcus sanguis; D018834:Chaperonin 60; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D018664:Interleukin-12