Congenital cataracts in two siblings with Wolfram syndrome.
BACKGROUND
Wolfram syndrome is characterized by optic atrophy, insulin dependent diabetes mellitus, diabetes insipidus and deafness. There are several other associated conditions reported in the literature, but congenital or early childhood cataracts are not among them.


METHODS
Observational case series with confirmatory genetic analysis.


RESULTS
A pair of siblings, followed over 17 years, who manifest congenital or early childhood cataracts, diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. They are both compound heterozygotes for mutations (V415 deletion and A684V substitution) in the WFS1 gene. Their father has congenital sensorineural hearing loss and developed optic atrophy. He is heterozygous for A684V in WFS1.


CONCLUSIONS
Wolfram syndrome should be in the differential diagnosis of genetic syndromes associated with congenital and early childhood cataracts. Here, we report on a mother who is a phenotypically normal carrier of an autosomal recessive Wolfram syndrome gene, and a father who has some of the findings of the syndrome and carries a single mutation that appears to be responsible for his hearing loss and optic atrophy. Their 2 children are compound heterozygotes and manifest the full Wolfram syndrome, in addition to cataracts.
Department of Ophthalmology, Northwestern University, Chicago, Illinois, USA.
Rebecca B
RB
Mets
Sarah B
SB
Emery
Marci M
MM
Lesperance
Marilyn B
MB
Mets
D002386:Cataract / Q000151:congenital*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000151:congenital; D006579:Heterozygote; D006801:Humans; D007223:Infant; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009154:Mutation; D009896:Optic Atrophy / Q000235:genetics; D035781:Siblings; D014792:Visual Acuity; D014929:Wolfram Syndrome / Q000175:diagnosis / Q000235:genetics*
D008565:Membrane Proteins; C114987:wolframin protein