Plasma concentration and cardiovascular effects of lidocaine during continuous epidural administration in dogs anesthetized with isoflurane.
The cardiovascular effects of continuous epidural administration (CEA) of lidocaine were investigated in anesthetized dogs. Loading epidural injections of 2, 4, or 6 mg/kg of lidocaine were followed by CEA with 1, 2, or 3 mg/kg/hr lidocaine, respectively, for 2 hr under 2.0% isoflurane anesthesia. Heart rate, direct blood pressure, cardiac index, and stroke volume decreased dose-dependently during CEA, whereas systemic vascular resistance did not significantly differ with dose, and no characteristic changes were observed in any groups. Plasma lidocaine concentration reached a steady state during CEA and increased in a dose-dependent manner. Circulatory suppression caused by lidocaine CEA was not attributable to peripheral vasodilation, but rather to the direct cardiac action of systemic lidocaine absorption from the peridural space.
Department of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University, Towada, Aomori. sakon@vmas.kitasato-u.ac.jp
Iwao
I
Sakonju
Kenichi
K
Maeda
Koichi
K
Karasawa
Toshiyuki
T
Tadokoro
Tomoko
T
Kakuta
Katsuaki
K
Takase
D000767:Anesthesia, Epidural / Q000009:adverse effects / Q000662:veterinary; D000769:Anesthesia, Inhalation / Q000662:veterinary; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D007268:Injections, Epidural; D007530:Isoflurane / Q000494:pharmacology*; D008012:Lidocaine / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000779:Anesthetics, Local; D008012:Lidocaine; D007530:Isoflurane