Safety of concurrent administration of dexrazoxane and doxorubicin in the canine cancer patient.
Doxorubicin may cause a rare but serious cardiotoxicity. Dexrazoxane is a cardioprotectant drug used to reduce the risk of cardiotoxicity in human patients. In this study, 25 tumour-bearing dogs were treated with concurrent doxorubicin and dexrazoxane. The total number of doses of dexrazoxane given was 54 (range 1-5 doses per dog, median 2 doses). Five dogs received more than 165 mg m(2) cumulative doxorubicin dose before starting dexrazoxane. Haematologic, gastrointestinal and cardiovascular toxicities were considered tolerable. The combination of doxorubicin with dexrazoxane was well tolerated with minimal side-effects in this patient cohort. Future studies are required to evaluate potential cardioprotective effects of dexrazoxane given concurrently with doxorubicin.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
W M
WM
FitzPatrick
N G
NG
Dervisis
B E
BE
Kitchell
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary; D006331:Heart Diseases / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D009369:Neoplasms / Q000188:drug therapy*; D011929:Razoxane / Q000008:administration & dosage* / Q000627:therapeutic use
D002317:Cardiovascular Agents; D011929:Razoxane; D004317:Doxorubicin