Critical association of ncRNA with introns.
It has been widely acknowledged that non-coding RNAs are master-regulators of genomic functions. However, the significance of the presence of ncRNA within introns has not received proper attention. ncRNA within introns are commonly produced through the post-splicing process and are specific signals of gene transcription events, impacting many other genes and modulating their expression. This study, along with the following discussion, details the association of thousands of ncRNAs--snoRNA, miRNA, siRNA, piRNA and long ncRNA--within human introns. We propose that such an association between human introns and ncRNAs has a pronounced synergistic effect with important implications for fine-tuning gene expression patterns across the entire genome.
University of Toledo Health Science Campus, University of Toledo Health Science Campus, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
David
D
Rearick
Ashwin
A
Prakash
Andrew
A
McSweeny
Samuel S
SS
Shepard
Larisa
L
Fedorova
Alexei
A
Fedorov
D000818:Animals; D006801:Humans; D007438:Introns; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism; D012326:RNA Splicing; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism; D020537:RNA, Small Nucleolar / Q000737:chemistry / Q000378:metabolism; D058727:RNA, Small Untranslated / Q000737:chemistry* / Q000378:metabolism*; D022661:RNA, Untranslated / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic
D035683:MicroRNAs; D034741:RNA, Small Interfering; D020537:RNA, Small Nucleolar; D058727:RNA, Small Untranslated; D022661:RNA, Untranslated