Effect of oseltamivir on catecholamines and select oxidative stress markers in the presence of oligoelements in the rat brain.
The effect that osteltamivir has on the metabolism of catecholamines and oxidative damage in the brains of young patients remains unclear. The purpose of this study was to measure the effects of oseltamivir, in the presence of oligoelements, on biogenic amines and select oxidative biomarkers in the brains of uninfected, young rats under normal conditions. The study was conducted using male Wistar rats intraperitoneally treated for three days with either a control dose of 0.9 % NaCl, oseltamivir (50 mg/kg), oligoelements (50 μL/rat), or oseltamivir (50 mg/kg) and oligoelements (50 μL/rat). The brain tissue extracted from the treated rats was used to determine the concentrations of adrenaline, noradrenaline, and dopamine, as well as the levels of GSH, lipid peroxidation, and ATPase activity. An increase in the concentration of adrenaline and noradrenaline and in the level of GSH in the group treated with oligoelements (p < 0.001) was observed, while the group treated with oseltamivir and oligoelements, the levels of dopamine increased (p < 0.001), and in the groups treated with oligoelements alone or combination with oseltamivir a decrease in lipid peroxidation was observed (p < 0.001). The results of this study suggest that the consumption of oseltamivir and oligoelements induce biphasic changes in the metabolism of catecholamines; thereby, inducing a protective mechanism against oxidative damage in the brains of young rats.
Laboratorio de Neuroquímica, Instituto Nacional de Pediatría, Avenida Imán No.1, México City, México.
David Calderón
DC
Guzmán
Ernestina Hernández
EH
García
Norma Osnaya
NO
Brizuela
Francisca Trujillo
FT
Jiménez
Gerardo Barragán
GB
Mejía
Hugo Juárez
HJ
Olguín
Daniel Santamaría
DS
del Ángel
Nuñez A
NA
Elvira
Liliana Carmona
LC
Aparicio
D000251:Adenosine Triphosphatases; D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D053139:Oseltamivir / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014131:Trace Elements / Q000633:toxicity*
D015415:Biomarkers; D002395:Catecholamines; D014131:Trace Elements; D053139:Oseltamivir; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D005978:Glutathione; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine